Development and characterization of recombinant ovine coagulation factor VIII.

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Philip M Zakas

Full Text Available Animal models of the bleeding disorder, hemophilia A, have been an integral component of the biopharmaceutical development process and have facilitated the development of recombinant coagulation factor VIII (fVIII products capable of restoring median survival of persons with hemophilia A to that of the general population. However, there remain several limitations to recombinant fVIII as a biotherapeutic, including invasiveness of intravenous infusion, short half-life, immunogenicity, and lack of availability to the majority of the world's population. The recently described ovine model of hemophilia A is the largest and most accurate phenocopy. Affected sheep die prematurely due to bleeding-related pathogenesis and display robust adaptive humoral immunity to non-ovine fVIII. Herein, we describe the development and characterization of recombinant ovine fVIII (ofVIII to support further the utility of the ovine hemophilia A model. Full-length and B-domain deleted (BDD ofVIII cDNAs were generated and demonstrated to facilitate greater biosynthetic rates than their human fVIII counterparts while both BDD constructs showed greater expression rates than the same-species full-length versions. A top recombinant BDD ofVIII producing baby hamster kidney clone was identified and used to biosynthesize raw material for purification and biochemical characterization. Highly purified recombinant BDD ofVIII preparations possess a specific activity nearly 2-fold higher than recombinant BDD human fVIII and display a differential glycosylation pattern. However, binding to the carrier protein, von Willebrand factor, which is critical for stability of fVIII in circulation, is indistinguishable. Decay of thrombin-activated ofVIIIa is 2-fold slower than human fVIII indicating greater intrinsic stability. Furthermore, intravenous administration of ofVIII effectively reverses the bleeding phenotype in the murine model of hemophilia A. Recombinant ofVIII should facilitate

San Pedro River Aquifer Binational Report

Science.gov (United States)

Callegary, James B.; Minjárez Sosa, Ismael; Tapia Villaseñor, Elia María; dos Santos, Placido; Monreal Saavedra, Rogelio; Grijalva Noriega, Franciso Javier; Huth, A. K.; Gray, Floyd; Scott, C. A.; Megdal, Sharon; Oroz Ramos, L. A.; Rangel Medina, Miguel; Leenhouts, James M.

2016-01-01

The United States and Mexico share waters in a number of hydrological basins and aquifers that cross the international boundary. Both countries recognize that, in a region of scarce water resources and expanding populations, a greater scientific understanding of these aquifer systems would be beneficial. In light of this, the Mexican and U.S. Principal Engineers of the International Boundary and Water Commission (IBWC) signed the “Joint Report of the Principal Engineers Regarding the Joint Cooperative Process United States-Mexico for the Transboundary Aquifer Assessment Program" on August 19, 2009 (IBWC-CILA, 2009). This IBWC “Joint Report” serves as the framework for U.S.-Mexico coordination and dialogue to implement transboundary aquifer studies. The document clarifies several details about the program such as background, roles, responsibilities, funding, relevance of the international water treaties, and the use of information collected or compiled as part of the program. In the document, it was agreed by the parties involved, which included the IBWC, the Mexican National Water Commission (CONAGUA), the U.S. Geological Survey (USGS), and the Universities of Arizona and Sonora, to study two priority binational aquifers, one in the San Pedro River basin and the other in the Santa Cruz River basin. This report focuses on the Binational San Pedro Basin (BSPB). Reasons for the focus on and interest in this aquifer include the fact that it is shared by the two countries, that the San Pedro River has an elevated ecological value because of the riparian ecosystem that it sustains, and that water resources are needed to sustain the river, existing communities, and continued development. This study describes the aquifer’s characteristics in its binational context; however, most of the scientific work has been undertaken for many years by each country without full knowledge of the conditions on the other side of the border. The general objective of this study is to

The Emperor Dom Pedro II: his convulsive seizures when a boy O imperador Dom Pedro II: as suas crises convulsivas quando menino

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Marleide da Mota Gomes

2007-12-01

Full Text Available INTRODUCTION: Dom Pedro II, the Prince Heir and Emperor under regency, in a delicate period of the construction of the Brazilian nation, had convulsive seizures. OBJECTIVE: To investigate the convulsive seizures and related syndromes of Dom Pedro II and his family, besides the physicians in charge of the health care. METHOD: Narrative review based on primary and secondary sources. CONCLUSION: The scattered and self-limited convulsive seizures associated with physical and mental integrity favored a benign prognosis. Dom Pedro and his family presented rich history of epileptic seizures and febrile convulsion. This variety resembles the diagnosis of generalized epilepsy with febrile seizures plus that seems to be a combination of several syndromes with shared genetic susceptibility.INTRODUÇÃO: Dom Pedro, o príncipe herdeiro e imperador sob regência, em período delicado da formação da nação brasileira, apresentou crises convulsivas que geraram preocupação para o país. OBJETIVO: Investigar a história da epilepsia de Dom Pedro II e da sua família e procurar identificar quais tipos de crises epilépticas estavam presentes, além dos médicos envolvidos com os cuidados de saúde. MÉTODO: Revisão narrativa baseada em fontes primárias e secundárias. CONCLUSÃO: As crises convulsivas esparsas e auto-limitadas associadas a higidez física e mental de Dom Pedro II sugerem um prognóstico benigno. A história de epilepsia idiopática e convulsões febris no imperador e em outros membros da sua família aponta para o diagnóstico mais provável de Epilepsia Generalizada com Convulsões Febris Plus que é determinada por uma combinação de alguns tipos de manifestações epilépticas com suscetibilidade genética compartilhada.

Anotaciones al tema del Crucificado en Pedro de Mena

OpenAIRE

López-Guadalupe, Juan Jesús

2000-01-01

We know few natural size «Crucificados» of Pedro de Mena. Or that, es very important the study of the little size «Crucificados» worked for him. Through of those «Crucificados» and the tradition of granadine's sculpture school, it can be demostrated the existence of the natural size «Crucificados» in Pedro de Mena.No disponible

Anotaciones al tema del Crucificado en Pedro de Mena

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López-Guadalupe, Juan Jesús

2000-06-01

Full Text Available We know few natural size «Crucificados» of Pedro de Mena. Or that, es very important the study of the little size «Crucificados» worked for him. Through of those «Crucificados» and the tradition of granadine's sculpture school, it can be demostrated the existence of the natural size «Crucificados» in Pedro de Mena.No disponible

Quality, language, subdiscipline and promotion were associated with article accesses on Physiotherapy Evidence Database (PEDro).

Science.gov (United States)

Yamato, Tiê P; Arora, Mohit; Stevens, Matthew L; Elkins, Mark R; Moseley, Anne M

2018-03-01

To quantify the relationship between the number of times articles are accessed on the Physiotherapy Evidence Database (PEDro) and the article characteristics. A secondary aim was to examine the relationship between accesses and the number of citations of articles. The study was conducted to derive prediction models for the number of accesses of articles indexed on PEDro from factors that may influence an article's accesses. All articles available on PEDro from August 2014 to January 2015 were included. We extracted variables relating to the algorithm used to present PEDro search results (research design, year of publication, PEDro score, source of systematic review (Cochrane or non-Cochrane)) plus language, subdiscipline of physiotherapy, and whether articles were promoted to PEDro users. Three predictive models were examined using multiple regression analysis. Citation and journal impact factor were downloaded. There were 29,313 articles indexed in this period. We identified seven factors that predicted the number of accesses. More accesses were noted for factors related to the algorithm used to present PEDro search results (synthesis research (i.e., guidelines and reviews), recent articles, Cochrane reviews, and higher PEDro score) plus publication in English and being promoted to PEDro users. The musculoskeletal, neurology, orthopaedics, sports, and paediatrics subdisciplines were associated with more accesses. We also found that there was no association between number of accesses and citations. The number of times an article is accessed on PEDro is partly predicted by how condensed and high quality the evidence it contains is. Copyright © 2017 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

The influence of prophylactic factor VIII in severe hemophilia A

Science.gov (United States)

Gissel, Matthew; Whelihan, Matthew F; Ferris, Lauren A; Mann, Kenneth G; Rivard, Georges E; Brummel-Ziedins, Kathleen E

2013-01-01

Introduction Hemophilia A individuals displaying a similar genetic defect have heterogeneous clinical phenotypes. Aim To evaluate the underlying effect of exogenous factor (f)VIII on tissue factor (Tf)-initiated blood coagulation in severe hemophilia utilizing both empirical and computational models. Methods We investigated twenty-five clinically severe hemophilia A patients. All individuals were on fVIII prophylaxis and had not received fVIII from 0.25 to 4 days prior to phlebotomy. Coagulation was initiated by the addition of Tf to contact-pathway inhibited whole blood ± an anti-fVIII antibody. Aliquots were quenched over 20 min and analyzed for thrombin generation and fibrin formation. Coagulation factor levels were obtained and used to computationally predict thrombin generation with fVIII set to either zero or its value at the time of the draw. Results Due to prophylactic fVIII, at the time of the blood draw, the individuals had fVIII levels that ranged from hemophilia A. The combination of each individual's coagulation factors (outside of fVIII) determine each individual's baseline thrombin potential and may affect bleeding risk. PMID:21899664

Historical intensity VIII earthquakes along the Rhone valley (Valais, Switzerland): primary and secondary effects

Energy Technology Data Exchange (ETDEWEB)

Fritsche, S.; Faeh, D.; Schwarz-Zanetti, G.

2012-06-15

In recent years the upper Rhone Valley has been one of the most intensively investigated regions by the Swiss Seismological Service. The high seismicity in the region encourages research in the seismological field and one main focus has been historical seismology. This report presents the state of the art of our historical investigations by giving an overview of the effects of four damaging earthquakes with intensity larger than VII, for which a fairly large number of documents could be found and analyzed. The overview includes the events of 1584 (Aigle, epicentral intensity VIII), 1755 (Brig, epicentral intensity VIII), 1855 (Visp, epicentral intensity VIII), and 1946 (Sierre, epicentral intensity VIII for the main shock and intensity VII for the largest aftershock). The paper focuses mainly on primary and secondary effects in the epicentral region, providing the key data and a general characterization of the event. Generally, primary effects such as the reaction of the population and impact on buildings took more focus in the past. Thus building damage is more frequently described in historic documents. However, we also found a number of sources describing secondary effects such as landslides, snow avalanches, and liquefaction. Since the sources may be useful, we include citations of these documents. The 1584 Aigle event, for example, produced exceptional movements in the Lake of Geneva, which can be explained by an expanded sub aquatic slide with resultant tsunami and seiche. The strongest of the aftershocks of the 1584 event triggered a destructive landslide covering the villages Corbeyrier and Yvorne, Vaud. All macroseismic data on the discussed events are accessible through the web page of the Swiss Seismological Service (http://www.seismo.ethz.ch). (authors)

Factor VIII assay

Science.gov (United States)

... this page: //medlineplus.gov/ency/article/003678.htm Factor VIII assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

El turismo de naturaleza en espacios naturales. El caso del Parque Regional de las Salinas y Arenales de San Pedro del Pinatar

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Gustavo A. Ballesteros Pelegrín

2014-01-01

Full Text Available Los espacios naturales atraen a turistas que buscan el contacto con la naturaleza, surgiendo nuevos productos turísticos. Surgen, de este modo, nuevos productos turísticos. En la oferta de turismo de naturaleza del Parque Regional de las Salinas y Arenales de San Pedro del Pinatar destaca: deportes en la naturaleza, aventura y ecoturismo. Este último se divide en: turismo ornitológico y fotográfico, que junto al tradicional de sol y playa y de salud, se ve favorecido por su situación geográfica, condiciones naturales y amplia oferta hotelera. Sin embargo, el turismo cultural basado en la tradición salinera y pesquera no ha sido desarrollado.

[Ehler-Danlos syndrome type VIII].

Science.gov (United States)

Ciarloni, L; Perrigouard, C; Lipsker, D; Cribier, B

2010-03-01

Ehlers-Danlos syndrome (EDS) comprises a heterogeneous group of diseases involving genetic collagen fibre impairment. We describe a case of a patient presenting the rare type VIII, in which dermatitis ocre was associated with parodontal disease, and which was diagnosed late. A 29-year-old man consulted for a pretibial ulcer present for seven years, resulting from a post-traumatic haematoma that had failed to heal. In view of the longiliner morphology, it had previously been diagnosed as Marfan syndrome. Subsequently, edentation was observed as well as "alveolar bone fragility". Examination revealed a marfanoid morphotype, a pretibial ulcer set within long-standing bilateral dermatitis ocre and papyraceous scars, but no joint hyperlaxity or cutaneous hyperelasticity. The diagnosis was consequently corrected to EDS type VIII. Type VIII is a rare form of EDS, and the molecular mechanism is poorly understood. The involvement of parodontal connective tissue suggests impairment of collagen I and III proteins. It is important to identify this type of the disease since it involves parodontal disease for which early treatment is required in order to try to prevent edentation. The present case demonstrates the importance of diagnosis, which may be based upon appearance of bilateral dermatitis ocre from the age of 15 years associated with skin fragility. This sign is not part of the classical picture of Marfan syndrome, with which EDS type VIII is often confounded. Copyright 2009 Elsevier Masson SAS. All rights reserved.

Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin

International Nuclear Information System (INIS)

Hill-Eubanks, D.C.; Parker, C.G.; Lollar, P.

1989-01-01

Blood coagulation factor VIII (fVIII) is a plasma protein that is decreased or absent in hemophilia A. It is isolated as a mixture of heterodimers that contain a variably sized heavy chain and a common light chain. Thrombin catalyzes the activation of fVIII in a reaction that is associated with cleavages in both types of chain. The authors isolated a serine protease from Bothrops jararacussu snake venom that catalyzes thrombin-like heavy-chain cleavage but not light-chain cleavage in porcine fVIII as judged by NaDodSO 4 /PAGE and N-terminal sequence analysis. Using a plasma-free assay of the ability of activated 125 I-fVIII to function as a cofactor in the activation of factor X by factor IXa, they found that fVIII is activated by the venom enzyme. The venom enzyme-activated fVIII was isolated in stable form by cation-exchange HPLC. von Willebrand factor inhibited venom enzyme-activated fVIII but not thrombin-activated fVIII. These results suggest that the binding of fVIII to von Willebrand factor depends on the presence of an intact light chain and that activated fVIII must dissociate from von Willebrand factor to exert its cofactor effect. Thus, proteolytic activation of fVIII-von Willebrand factor complex appears to be differentially regulated by light-chain cleavage to dissociate the complex and heavy-chain cleavage to activate the cofactor function

Nuevas esculturas de Pedro de Mena en Córdoba y Estepa

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García Luque, Manuel

2016-06-01

Full Text Available This article focuses on two new additions to the oeuvre of the Spanish sculptor Pedro de Mena: a small St Teresa of Ávila, in the church of St Peter Alcantara in Cordoba, and a St Peter penitent, in the hermitage of the Virgin of the Assumption in Estepa (Seville. Both attributions are based on stylistic and technical elements, as well as on their similarities with other documented and signed works by Mena, thereby suggesting a date between the decades of the 1670s and 1680s.En este trabajo incorporamos dos nuevas obras al catálogo del escultor granadino Pedro de Mena: una Santa Teresa, conservada en la iglesia de San Pedro Alcántara de Córdoba, y un San Pedro arrepentido, en la ermita de la Asunción de Estepa (Sevilla. Se le atribuyen por razones de técnica, formato y estilo y se analizan en comparación con otras obras seguras y firmadas, lo que permite estrechar su datación en el contexto de las décadas de 1670 y 1680.

Environmental evidence of fossil fuel pollution in Laguna Chica de San Pedro lake sediments (Central Chile)

International Nuclear Information System (INIS)

Chirinos, L.; Rose, N.L.; Urrutia, R.; Munoz, P.; Torrejon, F.; Torres, L.; Cruces, F.; Araneda, A.; Zaror, C.

2006-01-01

This paper describes lake sediment spheroidal carbonaceous particle (SCP) profiles from Laguna Chica San Pedro, located in the Biobio Region, Chile (36 o 51' S, 73 o 05' W). The earliest presence of SCPs was found at 16 cm depth, corresponding to the 1915-1937 period, at the very onset of industrial activities in the study area. No SCPs were found at lower depths. SCP concentrations in Laguna Chica San Pedro lake sediments were directly related to local industrial activities. Moreover, no SCPs were found in Galletue lake (38 o 41' S, 71 o 17.5' W), a pristine high mountain water body used here as a reference site, suggesting that contribution from long distance atmospheric transport could be neglected, unlike published data from remote Northern Hemisphere lakes. These results are the first SCP sediment profiles from Chile, showing a direct relationship with fossil fuel consumption in the region. Cores were dated using the 21 Pb technique. - The lake sediment record of SCPs shows the record of fossil-fuel derived pollution in Central Chile

Environmental evidence of fossil fuel pollution in Laguna Chica de San Pedro lake sediments (Central Chile)

Energy Technology Data Exchange (ETDEWEB)

Chirinos, L. [Centro de Ciencias Ambientales EULA-Chile, Universidad de Concepcion, PO Box 160-C, Concepcion (Chile)]. E-mail: lchirin@pucp.edu.pe; Rose, N.L. [Environmental Change Research Centre, University College London, 26 Bedford Way, London WG1HOAP (United Kingdom); Urrutia, R. [Centro de Ciencias Ambientales EULA-Chile, Universidad de Concepcion, PO Box 160-C, Concepcion (Chile); Munoz, P. [Departamento de Biologia Marina, Universidad Catolica del Norte, Larrondo 1281, Coquimbo (Chile); Torrejon, F. [Centro de Ciencias Ambientales EULA-Chile, Universidad de Concepcion, PO Box 160-C, Concepcion (Chile); Torres, L. [Departamento de Botanica, Universidad de Concepcion, Concepcion (Chile); Cruces, F. [Departamento de Botanica, Universidad de Concepcion, Concepcion (Chile); Araneda, A. [Centro de Ciencias Ambientales EULA-Chile, Universidad de Concepcion, PO Box 160-C, Concepcion (Chile); Zaror, C. [Facultad de Ingenieria Quimica, Universidad de Concepcion, Concepcion (Chile)

2006-05-15

This paper describes lake sediment spheroidal carbonaceous particle (SCP) profiles from Laguna Chica San Pedro, located in the Biobio Region, Chile (36{sup o} 51' S, 73{sup o} 05' W). The earliest presence of SCPs was found at 16 cm depth, corresponding to the 1915-1937 period, at the very onset of industrial activities in the study area. No SCPs were found at lower depths. SCP concentrations in Laguna Chica San Pedro lake sediments were directly related to local industrial activities. Moreover, no SCPs were found in Galletue lake (38{sup o} 41' S, 71{sup o} 17.5' W), a pristine high mountain water body used here as a reference site, suggesting that contribution from long distance atmospheric transport could be neglected, unlike published data from remote Northern Hemisphere lakes. These results are the first SCP sediment profiles from Chile, showing a direct relationship with fossil fuel consumption in the region. Cores were dated using the {sup 21}Pb technique. - The lake sediment record of SCPs shows the record of fossil-fuel derived pollution in Central Chile.

Kirjanikud Pedro Krusten, Henrik Visnapuu ja teised / Edla Krusten ; intervjueerinud Martin Viirand

Index Scriptorium Estoniae

Krusten, Edla

2012-01-01

Pedro Krusteni lesk Edla Krusten räägib oma käekäigust sõja ajal, Saksamaal ja USA-s, oma abikaasast Pedro Krustenist ja vaimsest atmosfäärist, mis valitses välis-eestlaste seas Ameerika Ühendriikides. Artikkel põhineb Rahvusringhäälingu raadiosaatel "Maailmapilt" (2008)

Factoring in Factor VIII With Acute Ischemic Stroke.

Science.gov (United States)

Siegler, James E; Samai, Alyana; Albright, Karen C; Boehme, Amelia K; Martin-Schild, Sheryl

2015-10-01

There is growing research interest into the etiologies of cryptogenic stroke, in particular as it relates to hypercoagulable states. An elevation in serum levels of the procoagulant factor VIII is recognized as one such culprit of occult cerebral infarctions. It is the objective of the present review to summarize the molecular role of factor VIII in thrombogenesis and its clinical use in the diagnosis and prognosis of acute ischemic stroke. We also discuss the utility of screening for serum factor VIII levels among patients at risk for, or those who have experienced, ischemic stroke. © The Author(s) 2015.

Pedro Meyer vastutab oma piltide eest / Laura Kuusk

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Kuusk, Laura, 1982-

2007-01-01

Mehhiko fotograafi Pedro Meyeri tutvustus. P. Meyeri ettekande tekst "Kui dokumentaalne teile meeldis, siis digitaalset hakkate armastama", esitatud Soomes Jyväskyläs 2006. a. oktoobris toimunud fotograafiakonverentsil

ESPOSAS Y MADRES: LA SEXUALIDAD FEMENINA EN PEDRO PÁRAMO

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DULCE ISABEL AGUIRRE BARRERA

2008-01-01

Full Text Available El presente artículo analiza las manifestaciones de la sexualidad de seis personajes femeninos en Pedro Páramo, de Juan Rulfo (Dolores Preciado, la madre de Pedro Páramo, Eduviges Dyada, Dorotea, Justina Díaz y Damiana Cisneros, en relación con los dos roles sexuados (esposa y madre asociados con el Deber-Ser femenino arquetípico de la ideología androcéntrica, con el propósito de estudiar las diferentes "recreaciones" y/o "transgresiones" de dichos roles en cada uno de los casos.

Issues of affinity: exploring population structure in the Middle and Regional Developments Periods of San Pedro de Atacama, Chile.

Science.gov (United States)

Torres-Rouff, Christina; Knudson, Kelly J; Hubbe, Mark

2013-11-01

The Middle Period (AD 400-1000) in northern Chile's Atacama oases is characterized by an increase in social complexity and regional interaction, much of which was organized around the power and impact of the Tiwanaku polity. Despite the strong cultural influence of Tiwanaku and numerous other groups evident in interactions with Atacameños, the role of immigration into the oases during this period is unclear. While archaeological and bioarchaeological research in the region has shown no evidence that clearly indicates large groups of foreign immigrants, the contemporary increase in interregional exchange networks connecting the oases to other parts of the Andes suggests residential mobility and the possibility that movement of people both into and out of the oases accompanied these foreign influences. Here, we analyze biodistance through cranial non-metric traits in a skeletal sample from prehistoric San Pedro de Atacama to elucidate the extent of foreign influence in the oases and discuss its implications. We analyzed 715 individuals from the Middle Period (AD 400-1000) and later Regional Developments Period (AD 1000-1450), and found greater phenotypic differences between Middle Period cemeteries than among cemeteries in the subsequent period. We argue that this greater diversity extends beyond the relationship between the oases and the renowned Tiwanaku polity and reflects the role of the oases and its different ayllus as a node and way station for the Middle Period's myriad interregional networks. Copyright © 2013 Wiley Periodicals, Inc.

Idiopathic Acquired Hemophilia A with Undetectable Factor VIII Inhibitor

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Nicholas B. Abt

2014-01-01

Full Text Available Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient’s plasma was comprehensively studied to determine the cause of the acquired coagulopathy. Using the Nijmegen modification of the Bethesda assay, no factor VIII autoantibody was measureable despite varying the incubation time from 1 to 3 hours. Results. The aPTT was prolonged at 46.8 seconds, which did not correct in the 4 : 1 mix but did with 1 : 1 mix. Using a one stage factor VIII activity assay, the FVIII activity was 16% and chromogenic FVIII activity was also 16%. The patient was treated with recombinant FVII and transfusion, significantly reducing bleeding. Long-term therapy was initiated with cyclophosphamide and prednisone with normalization of FVIII activity. Conclusions. Physicians can be presented with the challenging clinical picture of an acquired factor VIII inhibitor without a detectable inhibitor by the Bethesda assay. Standard therapy for an acquired hemophilia A should be considered.

4p-5s transitions in YVII, VIII, ZrVIII, IX, NbIX, X and MoX, XI

International Nuclear Information System (INIS)

Rahimullah, K.; Chaghtai, M.S.Z.; Khatoon, S.

1976-01-01

The spectra of Y VII, VIII, Zr VIII, IX, Nb X and Mo X, XI are studied for the first time and the 1971 analysis of Nb IX is improved. By analyses of the transitions 4s 2 4psup(k)-4s 2 4psup(k-1)5s all the levels of the configurations 4p 3 , 4p 2 5s, 4p 2 and 4p5s are established in the spectra concerned. (Auth.)

Regional profile, energy-impacted communities: Region VIII

Energy Technology Data Exchange (ETDEWEB)

None

1979-03-01

This report has data on population, administration, finance, housing, health and safety, human services, education, and water and sewage for 325 energy-impacted communities. A review of current and potential energy developments in the region shows over 900 energy resource impacts listed for the 325 impacted communities. Coal development represents over one-third of the developments listed. Communities reporting coal development are distributed as follows: Colorado (36), Montana (42), North Dakota (61), South Dakota (13), Utah (73), and Wyoming (35). Energy-conversion initiatives represent another high incidence of energy-resource impact, with uranium development following closely with 83 communities reporting uranium development impact in the region. These projections indicate continued development of regional energy resources to serve national energy requirements. The 325 impacted communities as reported: Colorado (46), Montana (73), North Dakota (62), South Dakota (21), Utah (80), and Wyoming (43) follow a distribution pattern similar to that of future projects which illustrates that no area of the region will escape the impacts of energy development. (ERA citation 04:041706)

Hydrology of the middle San Pedro area, southeastern Arizona

Science.gov (United States)

Cordova, Jeffrey T.; Dickinson, Jesse; Beisner, Kimberly R.; Hopkins, Candice B.; Kennedy, Jeffrey R.; Pool, Donald R.; Glenn, Edward P.; Nagler, Pamela L.; Thomas, Blakemore E.

2015-05-05

In the middle San Pedro Watershed in southeastern Arizona, groundwater is the primary source of water supply for municipal, domestic, industrial, and agricultural use. The watershed comprises two smaller subareas, the Benson subarea and the Narrows-Redington subarea. Early 21st century projections for heavy population growth in the watershed have not yet become a reality, but increased groundwater withdrawals could have undesired consequences - such as decreased base flow to the San Pedro River, and groundwater-level declines - that would lead to the need to deepen existing wells. This report describes the hydrology, hydrochemistry, water quality, and development of a groundwater budget for the middle San Pedro Watershed, focusing primarily on the elements of groundwater movement that could be most useful for the development of a groundwater modelPrecipitation data from Tombstone, Arizona, and base flow at the stream-gaging station on the San Pedro River at Charleston both show relatively dry periods during the 1960s through the mid-1980s and in the mid-1990s to 2009, and wetter periods from the mid-1980s through the mid-1990s. Water levels in four out of five wells near the mountain fronts show cyclical patterns of recharge, with rates of recharge greatest in the early 1980s through the mid-1990s. Three wells near the San Pedro River recorded their lowest levels during the 1950s to the mid-1960s. The water-level record from one well, completed in the confined part of the coarse-grained lower basin fill, showed a decline of approximately 21 meters.Annual flow of the San Pedro River, measured at the Charleston and Redington gages, has decreased since the 1940s. The median annual streamflow and base flow at the gaging station on the river near Tombstone has decreased by 50 percent between the periods 1968–1986 and 1997–2009. Estimates of streamflow infiltration along the San Pedro River during 1914–2009 have decreased 44 percent, with the largest decreases in

Pedro Teixeira y su viaje por Mesopotamia

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Fuente del Pilar, José Javier

2005-04-01

Full Text Available Pedro Teixeira es un integrante notable de la ilustre nómina de los viajeros portugueses que, a finales del s, XVI y principios del XVII, ensancharon para Occidente las fronteras del mundo. Su conocimiento en España se debe a la publicación en 1994 de su obra «Relaciones del Origen, Descendencia y Sucesión de los Reyes de Persia, y de Harmuz, y de un viaje hecho por el autor dende la India hasta Italia por tierra», en edición realizada por el profesor Eduardo Barajas Sala, lamentablemente fallecido en 1997. En este artículo se ofrece una reseña biográfica de Pedro Teixeira, y un análisis del viaje narrado por el autor en la última parte de sus «Relaciones »: el que desde Ormuz le conducirá, a través de Mesopotamia, hasta la costa del Mediterráneo.…

40 CFR Appendix Viii to Part 600 - Fuel Economy Label Formats

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel Economy Label Formats VIII... POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. VIII Appendix VIII to Part 600—Fuel Economy Label Formats EC01MY92.117 EC01MY92.118 EC01MY92.119 EC01MY92.120...

Ehlers-Danlos Syndrome Type VIII: A Rare Cause of Leg Ulcers in Young Patients

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Sophie Ronceray

2013-01-01

Full Text Available Ehlers-Danlos syndrome type VIII (EDS-VIII is a very rare autosomal dominant disease characterized by early-onset periodontitis associated with features of Ehlers-Danlos syndrome. We report a 32-year-old man whose chronic leg ulcer led to the diagnosis of EDS-VIII. He had severe periodontitis with complete loss of permanent teeth and skin fragility with thin skin, atrophic scars, and brownish atrophic pretibial plaques. Leg ulcer is not a prominent feature of EDS-VIII. We suggest adding EDS-VIII to the list of rare diseases accounting for chronic leg ulcers, if this case report prompts others to report leg ulcers associated with EDS-VIII.

Aproximación a un fotógrafo y pintor desconocido: Fr. Pedro de Madrid, Pedro Satué, Foto Antsa

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José Javier Azanza López

2015-01-01

Full Text Available Este trabajo pretende ser una aproximación a un fotógrafo y pintor prácticamente desconocido, y trazar una secuencia biográ- ca hasta ahora inédita: Fr. Pedro de Madrid-Pedro Satué-Foto Antsa. Este polifacético artista (Madrid, 1880-1936 se inició en las técnicas pictóricas y fotográ cas en el colegio capuchino de Lekaroz (Navarra, mostrándose como un hábil copista de Murillo y resultando triunfador en el Certamen Fotográ co-Social celebrado en Pamplona en 1912 con su colección de caseríos vascos del Baztán. Tras secularizarse y recuperar su nombre civil, desarrolló su labor profesional como fotógrafo al frente de un estudio abierto en 1924 en Madrid, especializándose en el retrato artístico y colaborando en las revistas ilustradas más importantes de la época.

Defectos refractivos en estudiantes de la Escuela “Pedro D. Murillo” Refractive defects found in “Pedro D. Murillo” school students

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Yaimir Estévez Miranda

2011-12-01

Full Text Available Objetivo: Caracterizar los defectos refractivos en niños de edad escolar en la escuela “Pedro Murillo” en el centro “Ciudad Escolar Libertad”. Métodos: Se realizó un estudio descriptivo, transversal con la finalidad de conocer los trastornos refractivos en niños de la primaria “Pedro Murillo” en el municipio Marianao, Ciudad de la Habana, en el periodo comprendido de septiembre 2010 a febrero de 2011. El universo estuvo formado por 422 estudiantes. Fueron 844 ojos a los que se le realizó un examen oftalmológico completo. Se distribuyeron según el defecto refractivo y su grado de severidad, edad, género y la frecuencia de la ambliopía. Resultados: El astigmatismo se presentó como la ametropía más frecuente para un 63,4 % y predominó el astigmatismo miópico compuesto. De las ametropías estudiadas prevaleció su forma leve (83 %. Se encontró una frecuencia de ambliopía de 3,7 % en los escolares. Conclusión: El comportamiento de los defectos refractivos observado, estuvo dentro de las cifras esperadas en relación a los reportes internacionales referidos al tema.Objectives: To characterize the refractive defects in children of school age in “Pedro Murillo” school in educational center Ciudad Libertad. Methods: A descriptive study and cross-sectional study was carried out to knowing the refractive disorders in elementary school children in “Pedro Murillo” school Marianao municipality, La Havana, in the from September 2010 to February, 2011. The universe was formed by 422 students. A complete ophthalmologic exam was performed on 844 eyes. They were distributed according to the refractive defect and their degree of severity, age, gender and the frequency of the amblyopia. Results: The astigmatism was the most frequent ametropia for 63.4 %, the compound myopic astigmatism prevailed. Of the studied ametropias their mild form prevailed for 83 %. The frequency of amblyopia was 3.7 % in students. Conclusions: The

Os primeiros filmes de Joaquim Pedro de Andrade: história e linguagem

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Tatiana Pontes de Oliveira

2014-12-01

Full Text Available The early films by Joaquim Pedro de Andrade: history and language – Joaquim Pedro de Andrade: primeiros tempos (early days four films by this “Cinema Novo” director are analyzed. From a historical research, the analysis focus is on this filmmaker’s training period and his initial films. His reflections on relations between fiction cinema and documentary, besides the specificities of the cinematographic language are highlighted.

Blood coagulation factor VIII

Indian Academy of Sciences (India)

Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights current knowledge on selected aspects of FVIII in which both the scientist and the ...

Agnostic stacking of intergalactic doublet absorption: measuring the Ne VIII population

Science.gov (United States)

Frank, Stephan; Pieri, Matthew M.; Mathur, Smita; Danforth, Charles W.; Shull, J. Michael

2018-05-01

We present a blind search for doublet intergalactic metal absorption with a method dubbed `agnostic stacking'. Using a forward-modelling framework, we combine this with direct detections in the literature to measure the overall metal population. We apply this novel approach to the search for Ne VIII absorption in a set of 26 high-quality COS spectra. We probe to an unprecedented low limit of log N>12.3 at 0.47≤z ≤1.34 over a path-length Δz = 7.36. This method selects apparent absorption without requiring knowledge of its source. Stacking this mixed population dilutes doublet features in composite spectra in a deterministic manner, allowing us to measure the proportion corresponding to Ne VIII absorption. We stack potential Ne VIII absorption in two regimes: absorption too weak to be significant in direct line studies (12.3 13.7). We do not detect Ne VIII absorption in either regime. Combining our measurements with direct detections, we find that the Ne VIII population is reproduced with a power-law column density distribution function with slope β = -1.86 ^{+0.18 }_{ -0.26} and normalization log f_{13.7} = -13.99 ^{+0.20 }_{ -0.23}, leading to an incidence rate of strong Ne VIII absorbers dn/dz =1.38 ^{+0.97 }_{ -0.82}. We infer a cosmic mass density for Ne VIII gas with 12.3 value significantly lower that than predicted by recent simulations. We translate this density into an estimate of the baryon density Ωb ≈ 1.8 × 10-3, constituting 4 per cent of the total baryonic mass.

Lessons for Integrated Water Resources Management from the San Pedro HELP Basin on the U.S.-Mexico Border

Science.gov (United States)

Browning, A.; Goodrich, D.; Varady, R.; Richter, H.

2007-12-01

The San Pedro Basin sits within an intermountain ecotone with the Sonoran and Chihuahuan Deserts to the west and east and the Rocky Mountain and Sierra Madre Mountain habitats to the north and south. The headwaters of the basin originate in northern Sonora and flow north into southeast Arizona. As the region's only remaining perennial stream, the San Pedro River serves as an international flyway for over 400 bird species. It is one of the western hemisphere's most ecologically diverse areas with some 20 different biotic communities, and "possesses one of the richest assemblages of land mammal species in the world." Large mining, military, and municipal entities are major users of the same groundwater resources that maintain perennial flow in the San Pedro. This presentation describes empirical evidence of the positive impacts on watershed management of scientists and policy researchers working closely with water managers and elected officials in a functioning HELP basin. We posit that when hydrologists help watershed groups understand the processes controlling water quality and quantity, and when managers and stakeholders connect these processes to social, economic and legal issues then transboundary cooperation in policymaking and water management is most effective. The distinctive physical and socioeconomic characteristics of the basin as well as differences in institutional regulations, water law issues, and their local implementations in Arizona and Sonora are discussed. We illustrate how stakeholders and scientific researchers in both countries strive to balance ecosystem needs with human demands to create new, integrated basin management. Finally, we describe how the accomplishments of the San Pedro collaborative process, including the use of environmental-conflict-resolution tools, have contributed to the UNESCO HELP (Hydrology for the Environment, Life, and Policy) agenda.

Institutions and Societal Impacts of Climate in the Lower Colorado and San Pedro Basins of the U.S.-Mexico Border Region

Science.gov (United States)

Varady, R. G.; Wilder, M.; Morehouse, B. J.; Garfin, G. M.

2007-05-01

The U.S. Southwest and Mexico border region feature two prominent river basins, the Colorado and Rio Grande, and ecologically important sub-basins such as the San Pedro. The area within which these transboundary basins lie is characterized by overall aridity and high climatic variability over seasonal to decadal and longer time scales. Throughout human occupation, numerous and diverse strategies for buffering climate impacts have emerged. The most notable response has been an increasingly complex system of institutions and structures designed to buffer water scarcity. The Colorado River Compact, and the laws governing allocation of waters from the Rio Grande River, together with the dams, hydropower generators, canals and other engineered features, represent two of the most complex systems. Drought nevertheless remains a looming specter across much of the binational border region. Institutional mechanisms for responding to drought range from awareness-raising and capacity-building efforts, to implementation of formal drought plans, to storing water to make up for deficits, and water conservation rules that become increasingly stringent as drought intensifies. A number of formal and informal binational institutions operate in the region. Some are venerable, like the century-old International Boundary and Water Commission (IBWC) and its Mexican counterpart the Comision Internacional de Limites y Agua (CILA). Others, like the Border Environment Cooperation Commission and the North American Development Bank, were created in the mid-1990s with the North American Free Trade Agreement. These institutions, both domestic and transnational, operate in a complex binational, bicultural environment with contrasting legal and administrative traditions. Under such constraints, they manage water resources and ecosystems and attempt to improve water and sanitation infrastructure in the context of deep and extended drought. But in spite of their efforts, society and natural habitat

The labour ward analgesic service at King Edward VIII Hospital ...

African Journals Online (AJOL)

The labour ward analgesic service at King Edward VIII. Hospital, Durban. D. A. ROCKE, C. C. ROUT, H. D. RUSSELL, S. SINGH. Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever.

Contrasting trends of tuberculosis in the cities of San Pedro Sula and Tegucigalpa, Honduras, 2005-2014.

Science.gov (United States)

Varela-Martínez, Cecilia; Yadon, Zaida E; Marín, Diana; Heldal, Einar

2016-01-01

Objective To 1) describe and compare the trends of tuberculosis (TB) case notification rates (CNRs) and treatment outcomes in the two largest cities in Honduras (San Pedro Sula and Tegucigalpa) for the period 2005-2014 and 2) identify possible related socioeconomic and health sector factors. Methods This retrospective ecological operational research study used aggregated data from the National TB Program (socioeconomic and health sector information and individual data from the 2014 TB case notification report). Results TB CNRs declined steadily over the study period in Tegucigalpa (from 46 to 28 per 100 000 inhabitants) but remained high in San Pedro Sula (decreasing from 89 to 78 per 100 000 inhabitants). Similar trends were observed for smear-positive TB. While presumptive TB cases examined were similar for both cities, in San Pedro Sula the proportions of presumptive cases with a positive smear; (7.7% versus 3.6%) relapses (8.9% versus 4.2%); and patients lost to follow-up (10.9% versus 2.7%) were significantly higher, and the treatment success lower (75.7% versus 87.0%). San Pedro Sula had lower annual income per capita, fewer public sector health workers and facilities, and a higher and increasing homicide index. The 2014 TB case data from San Pedro Sula showed a significantly lower median age and a higher proportion of assembly plant workers, prisoners, drug abusers, and diabetes. Conclusions The TB rate was higher and treatment success lower, and health care resources and socio-demographic indicators less favorable, in San Pedro Sula versus Tegucigalpa. City authorities, the NTP, and the health sector overall should strengthen early case detection, treatment, and infection control, involving both public and private health sectors.

VIII International Meeting on Lorentzian Geometry

CERN Document Server

Flores, José; Palomo, Francisco; GeLoMa 2016; Lorentzian geometry and related topics

2017-01-01

This volume contains a collection of research papers and useful surveys by experts in the field which provide a representative picture of the current status of this fascinating area. Based on contributions from the VIII International Meeting on Lorentzian Geometry, held at the University of Málaga, Spain, this volume covers topics such as distinguished (maximal, trapped, null, spacelike, constant mean curvature, umbilical...) submanifolds, causal completion of spacetimes, stationary regions and horizons in spacetimes, solitons in semi-Riemannian manifolds, relation between Lorentzian and Finslerian geometries and the oscillator spacetime. In the last decades Lorentzian geometry has experienced a significant impulse, which has transformed it from just a mathematical tool for general relativity to a consolidated branch of differential geometry, interesting in and of itself. Nowadays, this field provides a framework where many different mathematical techniques arise with applications to multiple parts of mathem...

Reservoir Considerations and Direct Uses of São Pedro do Sul Hydromineral and Geothermal Field, Northern Portugal

Science.gov (United States)

Ferreira Gomes, L. M.; Neves Trota, A. P.; Sousa Oliveira, A.; Soares Almeida, S. M.

2017-12-01

upflow is assumed to be the main driven factors that explain the occurrence of hot spring in regions with normal to slightly abnormal geothermal gradient. Actual thermal output of the captured fluid in the São Pedro do Sul Hydrothermal area is not fully used, namely in summer times. Thus the main focus for the concessionary includes the saturation of the actual Termas heat power capacity either in the SPA utilization and expansion for newer users in the district heating system. Further studies must be conducted in order to ascertain for possible source deep exploitation to refine quantitatively the São Pedro do Sul reservoir conceptual model in order to make sustainable wise management of this important natural resource, critical for the São Pedro do Sul municipality development and also contributing for the Portuguese sustainable economic growth. In this paper we give new insights for the knowledge of São Pedro do Sul Hydromineral and Geothermal Field, namely the geothermal reservoir, the concession hot water exploitation and future perspectives for upcoming sustainable developments of this valuable natural resource.

Effects of reintroduced beaver (Castor canadensis) on riparian bird community structure along the upper San Pedro River, southeastern Arizona and northern Sonora, Mexico

Science.gov (United States)

Johnson, Glenn E.; van Riper, Charles

2014-01-01

Chapter 1.—We measured bird abundance and richness along the upper San Pedro River in 2005 and 2006, in order to document how beavers (Castor canadensis) may act as ecosystem engineers after their reintroduction to a desert riparian area in the Southwestern United States. In areas where beavers colonized, we found higher bird abundance and richness of bird groups, such as all breeding birds, insectivorous birds, and riparian specialists, and higher relative abundance of many individual species—including several avian species of conservation concern. Chapter 2.—We conducted bird surveys in riparian areas along the upper San Pedro River in southeastern Arizona (United States) and northern Sonora (Mexico) in order to describe factors influencing bird community dynamics and the distribution and abundance of species, particularly those of conservation concern. These surveys were also used to document the effects of the ecosystem-altering activities of a recently reintroduced beavers (Castor canadensis). Chapter 3.—We reviewed Southwestern Willow Flycatcher (Empidonax traillii extimus) nest records and investigated the potential for future breeding along the upper San Pedro River in southeastern Arizona, where in July 2005 we encountered the southernmost verifiable nest attempt for the species. Continued conservation and management of the area’s riparian vegetation and surface water has potential to contribute additional breeding sites for this endangered Willow Flycatcher subspecies. Given the nest record along the upper San Pedro River and the presence of high-density breeding sites to the north, the native cottonwood-willow forests of the upper San Pedro River could become increasingly important to E. t. extimus recovery, especially considering the anticipated effect of the tamarisk leaf beetle (Diorhabda carinulata) on riparian habitat north of the region.

Thermoelectrical properties of the compounds ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt)

Energy Technology Data Exchange (ETDEWEB)

Oestreich, J; Probst, U; Richardt, F; Bucher, E [University of Konstanz, PO Box X916, D-78457 Konstanz (Germany)

2003-02-05

The research into new materials with good thermoelectric properties has revealed new compounds consisting of metallic elements (Bando Y, Suemitsu T, Takagi K, Tokushima H, Echizen Y, Katoh K, Umeo K, Maeda Y and Takabatake T 2000 J. Alloys Compounds 313 1-6, Ghelani N, Loo S, Chung D, Sportouch S, Nardi S, Kanatzidis M, Hogan T and Nolas G 2000 Mater. Res. Soc. 626 Z8.6.1). The half-Heusler compound ZrNiSn, in particular, shows promising thermoelectric properties and has been studied by many scientists during recent years (Uher C, Hu S, Yang J, Meisner G P and Morelli D T 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 485-8, Romaka L P, Stadnyk Yu V, Goryn A M, Gorelenko Yu K and Skolozdra R V 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 516-19, Hohl H, Ramirez A P, Goldmann C, Ernst G, Woelfing B and Bucher E 1998 J. Phys.: Condens. Matter 11 1697-709, Oestreich J, Kaefer W, Richardt F, Probst U and Bucher E 1999 Proc. 5th European Workshop on Thermoelectrics pp 192-5). In an effort to find new thermoelectric materials, the half-Heusler compounds of the groups ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt) were synthesized by arc melting and the thermoelectric properties were examined by standard characterization methods. Doping experiments showed that it is possible to change the electrical properties of the compounds while retaining the half-Heusler structure. Within the two groups, YPtSb showed the best thermoelectrical properties. At a temperature of 400 K the electrical conductivity of YPtSb is 748{omega}{sup -1} cm{sup -1} and the Seebeck coefficient is 116.3{mu}V K{sup -1}. The thermal conductivity at 400 K extrapolated using the Wiedemann-Franz law is 2.87 W K{sup -1} m{sup -1}. This leads to a dimensionless figure of merit of 0.14.

Pedro Ventura de Puga, último señor de la Casa de Fontefiz

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Leirós de la Peña, Paz

2007-12-01

Full Text Available This paper is based on documentation from Casa de Fontefiz kept in the AHPOR. The documents cover the period from the sixteenth to nineteenth century and provide information about the patrimony of the house, its social position and the political activities of Pedro Ventura de Puga during the firts half of the nineteenth century. The first part is focused on the origin and evolution of patrimony, way of living, nobility abuses (including social and sexual aspects, and the difficulties to keep the social status. In the second part, Pedro Ventura plays the main role: his participation in the War of Independence and the building of the liberal state. He is a relevant character to undestand the adaptation of nobility to an age of political changes and social ad economical survivals. The defense of the constitution and his participation in the liberal regime is compatible with the maintenance of a economy based on the collection of taxes and nobility titles. Pedro Ventura is politically registered as a moderate liberalist.

Este trabajo está basado en la documentación de la Casa de Fontefiz, conservada en al AHPOR. Los documentos abarcan desde el siglo XVI al XIX y nos aportan información sobre el patrimonio de la Casa, su posición social y las actividades políticas de Pedro Ventura de Puga en la primera mitad del siglo XIX. La primera parte se centra en el origen y evolución del patrimonio, modo de vida, abusos de la hidalguía en el plano social y sexual y las dificultades para mantener el stuatus social. La segunda parte tiene como protagonista a Pedro Ventura de Puga, su participación en la Guerra de la Independencia y en la construcción del estado liberal. Es una figura clave para entender la adaptación de la hidalguía a una época de cambios políticos y de pervivencias sociales y económicas. La defensa de la Constitución y la participación en el régimen liberal es compatible con el mantenimiento de una econocmía basada en

Diversidad florística y conservación del Santuario Regional de Piura Manglares San Pedro de Vice-Sechura

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Manuel Charcape-Ravelo

2013-05-01

Full Text Available El presente trabajo se llevó a cabo con la finalidad de conocer la composición de las fanerógamas del Santuario Regional de Piura Manglares San Pedro de Vice-Sechura. Su importancia radica en que es el manglar más austral del Pacífico de Sudamérica. Dicho trabajo fue realizado desde abril del 2000 hasta febrero del 2004. Para la realización del presente estudio se realizaron visitas periódicas cada dos meses al lugar, se colectaron las plantas bajo procedimientos estándar. Las muestras se determinaron en el lugar y algunas fueron llevadas al laboratorio de Botánica de la Universidad Nacional de Piura y al laboratorio de Botánica Fanerogámica de la Universidad Nacional de Trujillo para su determinación definitiva; luego, las muestras se depositaron en el herbario en formación de la Universidad Nacional de Piura. El manglar consiste en primer lugar de árboles y arbustos de Avicennia germinans (L. L. (Verbenaceae «mangle prieto». En el presente inventario se documentan un total de 44 especies de fanerógamas correspondiendo a 36 géneros en 21 familias para el manglar.

Application of hydrologic tools and monitoring to support managed aquifer recharge decision making in the Upper San Pedro River, Arizona, USA

Science.gov (United States)

Lacher, Laurel J.; Turner, Dale S.; Gungle, Bruce W.; Bushman, Brooke M.; Richter, Holly E.

2014-01-01

The San Pedro River originates in Sonora, Mexico, and flows north through Arizona, USA, to its confluence with the Gila River. The 92-km Upper San Pedro River is characterized by interrupted perennial flow, and serves as a vital wildlife corridor through this semiarid to arid region. Over the past century, groundwater pumping in this bi-national basin has depleted baseflows in the river. In 2007, the United States Geological Survey published the most recent groundwater model of the basin. This model served as the basis for predictive simulations, including maps of stream flow capture due to pumping and of stream flow restoration due to managed aquifer recharge. Simulation results show that ramping up near-stream recharge, as needed, to compensate for downward pumping-related stress on the water table, could sustain baseflows in the Upper San Pedro River at or above 2003 levels until the year 2100 with less than 4.7 million cubic meters per year (MCM/yr). Wet-dry mapping of the river over a period of 15 years developed a body of empirical evidence which, when combined with the simulation tools, provided powerful technical support to decision makers struggling to manage aquifer recharge to support baseflows in the river while also accommodating the economic needs of the basin.

Application of Hydrologic Tools and Monitoring to Support Managed Aquifer Recharge Decision Making in the Upper San Pedro River, Arizona, USA

Directory of Open Access Journals (Sweden)

Laurel J. Lacher

2014-11-01

Full Text Available The San Pedro River originates in Sonora, Mexico, and flows north through Arizona, USA, to its confluence with the Gila River. The 92-km Upper San Pedro River is characterized by interrupted perennial flow, and serves as a vital wildlife corridor through this semiarid to arid region. Over the past century, groundwater pumping in this bi-national basin has depleted baseflows in the river. In 2007, the United States Geological Survey published the most recent groundwater model of the basin. This model served as the basis for predictive simulations, including maps of stream flow capture due to pumping and of stream flow restoration due to managed aquifer recharge. Simulation results show that ramping up near-stream recharge, as needed, to compensate for downward pumping-related stress on the water table, could sustain baseflows in the Upper San Pedro River at or above 2003 levels until the year 2100 with less than 4.7 million cubic meters per year (MCM/yr. Wet-dry mapping of the river over a period of 15 years developed a body of empirical evidence which, when combined with the simulation tools, provided powerful technical support to decision makers struggling to manage aquifer recharge to support baseflows in the river while also accommodating the economic needs of the basin.

New study on the XeVIII spectrum

International Nuclear Information System (INIS)

Gallardo, M.; Raineri, M.; Giuliani, M.; Lagorio, C.; Padilla, S.; Sarmiento, R.; Reyna Almandos, J.G.

2005-01-01

Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters

New study on the XeVIII spectrum

Energy Technology Data Exchange (ETDEWEB)

Gallardo, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: gallardom@ciop.unlp.edu.ar; Raineri, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: monicar@ciop.unlp.edu.ar; Giuliani, M. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Lagorio, C. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Padilla, S. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Sarmiento, R. [Dto. De Fisica, Universidad del Atlantico, A.A 1890 Barranquilla (Colombia); Reyna Almandos, J.G. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: jreyna@ciop.unlp.edu.ar

2005-10-15

Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters.

Thermal Performance of Traditional and New Concept Houses in the Ancient Village of San Pedro De Atacama and Surroundings

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Massimo Palme

2014-05-01

Full Text Available Earth, wood and others traditional materials are still used in house constructions in many regions of the world, especially in the Andes. San Pedro de Atacama, for example, is a small town where earth blocks (adobes and rammed earth (tapial are important ways to construct, an art passed on through generations. Energy properties of earth are very interesting: thermal conductivity is low; heat storage capacity is high; color is variable and can be used to absorb or to reject solar radiation. However, nowadays the government social dwelling service is proposing a different type of construction, which does not maintain any relation with the tradition. This paper presents simulation studies and monitoring of four different San Pedro houses, constructed by using different techniques and materials. Results can be used to discuss the thermal performance needed in desert climate and the reliability of social dwelling service houses, under construction at this time in the town.

A arquitectura das Termas romanas de S. Pedro do Sul

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Helena Frade

1992-01-01

Full Text Available Comenzamos el trabajo con una introducción general en la que se pone de manifiesto la escasez de estudios sobre el termalismo antiguo en Portugal y la mala conservación de la mayoría de los restos conocidos. Pasamos, a continuación, a tratar del balneario de Sao Pedro do Sul, localizado en la feligresía de Várzea, ayuntamiento de Sao Pedro do Sul, provincia de Viseu, que es uno de los mejor conservados. Se realizaron algunas excavaciones en los años 50. No obstante, las investigaciones sistemáticas comenzaron en 1985. El edificio, de fundación romana, mantiene hasta hoy gran parte de la estructura primitiva, en la que pueden determinarse dos fases constructivas, de las que se dan sus características.We start this report with a general introduction in which the scarcity of studies about ancient thermalism in Portugal, and the bad preservation of the majority of the known ruins, is shown. We continué with the spa of Sao Pedro do Sul, province of Viseu, one of the best preserved. Several diggins were made in the 50's. How^ever, the systematic research started in 1985. The building, of román foundation, maintains today a big portion of its primitive structure, in wich two construction stages can be determined, whose characteristics are discribed here.

Astronaut Pedro Duque Watches A Water Bubble

Science.gov (United States)

2003-01-01

Aboard the International Space Station (ISS), European Space Agency astronaut Pedro Duque of Spain watches a water bubble float between a camera and himself. The bubble shows his reflection (reversed). Duque was launched aboard a Russian Soyuz TMA-3 spacecraft from the Baikonur Cosmodrome, Kazakhstan on October 18th, along with expedition-8 crew members Michael C. Foale, Mission Commander and NASA ISS Science Officer, and Cosmonaut Alexander Y. Kaleri, Soyuz Commander and flight engineer.

From Golden Age Mexican Cinema to Transnational Border Feminism: The Community of Spectators in "Loving Pedro Infante"

Science.gov (United States)

Heredia, Juanita

2008-01-01

The novel "Loving Pedro Infante" by Chicana writer Denise Chavez provides an insightful transcultural feminist critique of Golden Age Mexican cinema culture through a careful examination of gender roles. In the novel, the reception of Pedro Infante's films by spectators bridges generations and national spaces and leads to the formation…

Haemophilia A: Database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Tuddenham, E.G.D. (Clinical Research Centre, Harrow (United Kingdom)); Cooper, D.N. (Thrombosis Research Inst., London (United Kingdom)); Gitschier, J. (Univ. of California, San Francisco (United States)); Higuchi, M.; Kazazian, H.H.; Antonarakis, S.E. (Johns Hopkins Univ., Baltimore (United States)); Hoyer, L.W. (American Red Cross, Rockville (United States)); Yoshioka, A. (Nara Medical Coll., Kashihara City (Japan)); Peake, I.R. (Royal Hallamshire Hospital, Sheffield (United Kingdom)); Schwaab, R. (Inst. fuer Klinische Biochemie der Univ. Bonn (West Germany)); Lavergne, J.M. (Hopital de Bicetre (France)); Giannelli, F. (Guy' s Hospital, London (United Kingdom))

1991-09-25

Mutations at the factor VIII gene locus causing Haemophilia A have now been identified in many patients from a many ethnic groups. Earlier studies used biased methods which detected repetitive mutations at a few CG dinucleotides. More recently rapid gene scanning methods have uncovered an extreme diversity of mutations. Over 80 different point mutations, 6 insertions, 7 small deletions, and 60 large deletions have been characterized. Repetitive mutation has been proved for at least 16 CpG sites. All nonsense mutations cause severe disease. Most missense mutations appear to cause instability of the protein, but some are associated with production of dysfunctional factor VIII molecules, thereby localizing functionally critical regions of the cofactor. Variable phenotype has been observed in association with three of the latter class of genotype. This catalogue of gene lesions in Haemophilia A will be updated annually.

Hydrological conditions and evaluation of sustainable groundwater use in the Sierra Vista Subwatershed, Upper San Pedro Basin, southeastern Arizona

Science.gov (United States)

Gungle, Bruce; Callegary, James B.; Paretti, Nicholas V.; Kennedy, Jeffrey R.; Eastoe, Christopher J.; Turner, Dale S.; Dickinson, Jesse; Levick, Lainie R.; Sugg, Zachary P.

2016-08-18

This study assessed progress toward achieving sustainable groundwater use in the Sierra Vista Subwatershed of the Upper San Pedro Basin, Arizona, through evaluation of 14 indicators of sustainable use. Sustainable use of groundwater in the Sierra Vista Subwatershed requires, at a minimum, a stable rate of groundwater discharge to, and thus base flow in, the San Pedro River. Many of the 14 indicators are therefore related to long-term or short-term effects on base flow and provide us with a means to evaluate groundwater discharge to and base flow in the San Pedro River. The indicators were based primarily on 10 to 20 years of data monitoring in the subwatershed, ending in 2012, and included subwatershedwide indicators, riparian-system indicators, San Pedro River indicators, and springs indicators.

Effectiveness of Mind Mapping in English Teaching among VIII Standard Students

Science.gov (United States)

Hallen, D.; Sangeetha, N.

2015-01-01

The aim of the study is to find out the effectiveness of mind mapping technique over conventional method in teaching English at high school level (VIII), in terms of Control and Experimental group. The sample of the study comprised, 60 VIII Standard students in Tiruchendur Taluk. Mind Maps and Achievement Test (Pretest & Posttest) were…

Population pharmacokinetics of recombinant coagulation factor VIII-SingleChain in patients with severe hemophilia A.

Science.gov (United States)

Zhang, Y; Roberts, J; Tortorici, M; Veldman, A; St Ledger, K; Feussner, A; Sidhu, J

2017-06-01

Essentials rVIII-SingleChain is a unique recombinant factor VIII (FVIII) molecule. A population pharmacokinetic model was based on FVIII activity of severe hemophilia A patients. The model was used to simulate factor VIII activity-time profiles for various dosing scenarios. The model supports prolonged dosing of rVIII-SingleChain with intervals of up to twice per week. Background Single-chain recombinant coagulation factor VIII (rVIII-SingleChain) is a unique recombinant coagulation factor VIII molecule. Objectives To: (i) characterize the population pharmacokinetics (PK) of rVIII-SingleChain in patients with severe hemophilia A; (ii) identify correlates of variability in rVIII-SingleChain PK; and (iii) simulate various dosing scenarios of rVIII-SingleChain. Patients/Methods A population PK model was developed, based on FVIII activity levels of 130 patients with severe hemophilia A (n = 91 for ≥ 12-65 years; n = 39 for  85% and > 93% of patients were predicted to maintain FVIII activity level above 1 IU dL -1 , at all times with three-times-weekly dosing (given on days 0, 2, and 4.5) at the lowest (20 IU kg -1 ) and highest (50 IU kg -1 ) doses, respectively. For twice weekly dosing (days 0 and 3.5) of 50 IU kg -1 rVIII-SingleChain, 62-80% of patients across all ages were predicted to maintain a FVIII activity level above 1 IU dL -1 at day 7. Conclusions The population PK model adequately characterized rVIII-SingleChain PK, and the model can be utilized to simulate FVIII activity-time profiles for various dosing scenarios. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

Em torno da luz cristalina: clara voz de Pedro Salinas

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Cristiano Moreira

2015-06-01

Full Text Available http://dx.doi.org/10.5007/2176-8552.2016n20p147 O texto que segue pretende ler a poesia de Pedro Salinas e Jorge Guillén diante de uma perspectiva que faz da voz uma iluminação e uma resistência diante do tempo histórico e da predominância de uma leitura simples das imagens. Assim, alguns poemas escolhidos permitem uma leitura contemporânea a respeito da voz, seguindo o conceito de Stimmung recuperado por Giorgio Agamben e as lições de poesia de Paul Valéry, e formam aspectos imprescindíveis para ler a poesia destes poetas. Ao manter em sua produção uma conversação com seus predecessores, Pedro Salinas joga com o logos e faz da phoné matéria prima para sua obra.

The metalexicographical contribution of pedro a. fuertes-olivera and ...

African Journals Online (AJOL)

This article attempts to give a critical review of Pedro A. Fuertes-Olivera and Ascen-sión Arribas-Baño's Pedagogical Specialised Lexicography. It evaluates the book in view of the avail-able metalexicographical literature as well as current trends in practical LSP lexicography in the wake of rapid technological and ...

Reconnaissance radiological characterization for the White Point Nike Missile Site, San Pedro, California

International Nuclear Information System (INIS)

Espegren, M.L.; Jensen, M.K.; Pierce, G.A.; Smith, S.M.

1993-01-01

This report is the result of field work performed at the former White Point Nike Missile Site, San Pedro, California. The Hazardous Waste Remedial Actions Program tasked the Oak Ridge National Laboratory Pollutant Assessments Group in Grand Junction, Colo., with this project. The objective was to determine whether or not radioisotopes possibly associated with past Department of Defense (DOD) operations were present and within accepted background levels. The radiation survey was accomplished by performing three independent radiation surveys, both outdoors and indoors, and random soil sampling. Initially, the site was land surveyed to develop a grid block system. A background radiation investigation was performed out in the San Pedro area

Factors Associated with the Time of Admission among Notified Dengue Fever Cases in Region VIII Philippines from 2008 to 2014.

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Jason Echavez Abello

2016-10-01

Full Text Available In cases of Dengue fever, late hospital admission can lead to treatment delay and even death. In order to improve early disease notification and management, it is essential to investigate the factors affecting the time of admission of Dengue cases. This study determined the factors associated with the time of admission among notified Dengue cases. The study covered the period between 2008 and 2014 in Region VIII, Philippines. The factors assessed were age, sex, hospital sector, hospital level, disease severity based on the 1997 WHO Dengue classification, and period of admission (distinguishing between the 2010 Dengue epidemic and non-epidemic time. We analysed secondary data from the surveillance of notified Dengue cases. We calculated the association through chi-square test, ordinal logistic regression and linear regression at p value < 0.05. The study included 16,357 admitted Dengue cases. The reported cases included a majority of children (70.09%, mild cases of the disease (64.00%, patients from the public sector (69.82%, and non-tertiary hospitals (62.76%. Only 1.40% of cases had a laboratory confirmation. The epidemic period in 2010 comprised 48.68% of all the admitted cases during this period. Late admission was more likely among adults than children (p<0.05. The severe type of the disease was more likely to be admitted late than the mild type (p<0.05. Late admission was also more likely in public hospitals than in private hospitals (p<0.05; and within tertiary level hospitals than non-tertiary hospitals (p<0.05. Late admission was more likely during the non-epidemic period than the 2010 epidemic period (p<0.05. A case fatality rate of 1 or greater was significantly associated with children, severe diseases, tertiary hospitals and public hospitals when admitted late (p<0.05. Data suggests that early admission among child cases was common in Region VIII. This behavior is encouraging, and should be continued. However, further study is needed

Pedro Miguel Ruiz Carranza. Febrero 3, 1932 - Septiembre 12, 1998

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Lynch John Douglas

1999-11-01

Full Text Available Tres veces Director del Instituto de Ciencias Naturales, el Profesor Honorario Pedro M. Ruiz C. falleció en Bogotá el 12 de septiembre de 1998. Con su muerte, Colombia y la ciencia perdieron a un gran trabajador y sus colegas a un gran amigo.

VIII Brazilian Meeting on Simulational Physics (BMSP)

International Nuclear Information System (INIS)

Branco, N. S.; Figueiredo, W.; Plascak, J. A.; Santos, M.

2016-01-01

This special issue includes invited and selected articles of the VIII Brazilian Meeting on Simulational Physics (BMSP), held in Florianópolis, Santa Catarina, Brazil, from 3rd to 8th August, 2015. This is the eighth such meeting, and the second one to have contributed papers published in Journal of Physics: Conference Series (the other was the VII BMSP). The previous meetings in the BMSP series took place in the mountains of Minas Gerais, in the region of the Brazilian Pantanal, and in the shores of Paraíba. Now, for the first time, the Meeting was held in Florianópolis, with its pleasing shores, the capital of Santa Catarina state. The VIII BMSP brought together about 50 researchers from all over the world for a vibrant and productive conference. As in the previous meetings, the talks and posters highlighted recent advances in applications, algorithms, and implementation of computer simulation methods for the study of condensed matter, materials, and out of equilibrium, quantum and biologically motivated systems. We are sure that this meeting series will continue to be an important occasion for people working in simulational physics to exchange ideas and discuss the state of the art of this always expanding field. We are very glad to put together this special issue, and are most appreciative of the efforts of the editors of the Journal of Physics: Conference Series for making this publication possible. We are grateful for the outstanding work of the Florianopolis team, for the financial support of the Brazilian agencies CAPES and CNPq, and of the Federal Universities UFPB and UFSC. At last, but not least, we would like to acknowledge all of the authors for their written submissions. (paper)

Acquired high titre factor VIII inhibitor with underlying polyarteritis nodosa.

Science.gov (United States)

Snowden, J A; Hutchings, M; Spearing, R; Patton, W N

1997-05-01

We here present the case of a 70-year-old woman referred to our unit for investigation of bleeding. Investigations confirmed a high titre acquired Factor VIII inhibitor. In association there was relapse of systemic illness associated with anti-neutrophil cytoplasmic antibodies (atypical pattern) for which she had been treated five years previously. Immunosuppression was attempted, but it failed to have an impact both on the inhibitor titre and on the underlying disorder. The patient died from multi-organ failure and massive chest hemorrhage. Post-mortem showed necrotizing vasculitis of medium sized vessels at several sites, including the kidney, consistent with a diagnosis of polyarteritis nodosa. Although it is well recognised that Factor VIII inhibitors are found in conjunction with autoimmune disorders, this case is significant in that it is the first associated with histologically proven polyarteritis nodosa type vasculitis. The case illustrates the difficulties in the investigation and management of patients with acquired high titre Factor VIII inhibitors.

Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.

Science.gov (United States)

Rodgers, Susan; Duncan, Elizabeth

2017-01-01

Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in the milder forms. It is important that patients are diagnosed correctly, which includes placing them into the correct severity category of the disorder so that appropriate treatment can be given. Diagnosis is made by determination of the amount of FVIII:C in the blood, usually using a one-stage factor VIII:C assay. However, approximately one third of patients with mild or moderate hemophilia will have much lower results by the chromogenic assay, with some of them having normal results by the one-stage assay. The chromogenic factor VIII assay is used in some specialized hemophilia reference centers and is recommended for the diagnosis of mild hemophilia A, as this assay is considered to better reflect the severity status of hemophilia patients than the one-stage assay.

Pedro de Valencia, Francisco de Gurmendi and the Plomos de Granada

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Magnier, Grace

2003-12-01

Full Text Available The Inquisition in 1618 seized all the papers of Pedro de Valencia, renowned humanist, biblical scholar and chronicler of Philip III. The papers of other members of his circle were also confiscated. In this article I examine the two most important texts: Sobre el pergamino y láminas de Granada of Valencia and a Libelo Segundo of Francisco de Gurmendi, interpreter of Oriental languages for Philip III. The article is structured around Gurmendi's response to a memorial published in 1617 by Archbishop Pedro de Castro in defence of one of his translators. Gurmendi, working from his translation of the first two Lead Books, shows how these contain heretical ideas on the Trinity and how the memorialista has mistranslated many passages.

En 1618 la Inquisición confiscó todos los papeles de Pedro de Valencia, humanista insigne, exegeta bíblico y cronista del reino y de las Indias de Felipe III. También confiscó los papeles de otros miembros de su círculo. En este artículo examino los dos textos más importantes: Sobre el pergamino y láminas de Granada de Valencia y un Libelo segundo de Francisco de Gurmendi, intérprete en lenguas orientales del rey. El artículo se centra en la respuesta de Gurmendi a un memorial del Arzobispo Pedro de Castro en el que se defiende a uno de sus traductores. Partiendo de su traducción de los dos primeros libros plúmbeos, Gurmendi muestra las herejías trinitarias que éstos contienen y cómo el memorialista ha traducido mal muchos pasajes.

Pedro Salinas: la letra y la persona

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Escartín Gual, Montserrat

2002-12-01

Full Text Available This article is a Pedro Salinas's homage in the fifty anniversary of his death. Here, we analise his attitude in front of life and his securities through his poems, personal letters and essais. The poet criticizes the materialistic american stil of life, where he should live during his exile until his death (1936-1951. Against the hurry, the profitable things, the technology, the money..., Salinas believes in his language, slowness, friendship, contemplation of countryside, art, spiritualism, optimism, etc. Son of the Institución Libre de Enseñanza's ideas, his personal ethics looked for the biggest perfection trought the will.Este artículo es un homenaje a Pedro Salinas al cumplirse el cincuentenario de su muerte. En él, se analiza su actitud ante la vida y sus valores a través de sus poesías, cartas personales y ensayos. El poeta critica el materialismo del modelo americano en el que se vio obligado a vivir desde que se exilió hasta su muerte (1936-1951. Frente a la prisa, lo rentable, la tecnología, el dinero...; Salinas cree en su idioma, la lentitud, la amistad, la contemplación del paisaje, el arte, lo espiritual, el optimismo, etc. Hijo de las ideas de la Institución Libre de Enseñanza, su ética personal buscó la mayor perfección a través de la voluntad.

Type VIII collagen is elevated in diseases associated with angiogenesis and vascular remodeling

DEFF Research Database (Denmark)

Hansen, N. U. B.; Willumsen, N.; Bülow Sand, Jannie Marie

2016-01-01

Objectives Type VIII collagen is involved in angiogenesis and remodeling of arteries. We hypothesized that type VIII collagen was upregulated in diseases associated with vascular remodeling, e.g. pulmonary fibrosis and cancer. In this paper we present the development and validation of a competitive...

The F309S mutation increases factor VIII secretion in human cell line

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Daianne Maciely Carvalho Fantacini

2016-06-01

Full Text Available ABSTRACT OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII production in the HEK 293 human cell line. Factor VIII activity was measured by chromogenic assay. Furthermore, the effects of chemical drugs on the culture were evaluated. RESULTS: The addition of the F309S mutation to a previously described FVIII variant increased FVIII secretion by 4.5 fold. Moreover, the addition of betaine or sodium-4-phenylbutyrate increased the secretion rate of FVIIIΔB proteins in HEK 293 cells, but the same effect was not seen for FVIIIΔB-F309S indicating that all the recombinant protein produced had been efficiently secreted. CONCLUSION: Bioengineering factor VIII expressed in human cells may lead to an efficient production of recombinant factor VIII and contribute toward low-cost coagulation factor replacement therapy for hemophilia A. FVIII-F309S produced in human cells can be effective in vivo.

Myosin VIII regulates protonemal patterning and developmental timing in the moss Physcomitrella patens.

Science.gov (United States)

Wu, Shu-Zon; Ritchie, Julie A; Pan, Ai-Hong; Quatrano, Ralph S; Bezanilla, Magdalena

2011-09-01

Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of RNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Δmyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Δmyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the absence of nutrient media, Δmyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Δmyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal cells, and accelerated development in the Δmyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P. patens.

Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine.

Science.gov (United States)

Gilbert, G E; Drinkwater, D

1993-09-21

Phosphatidylserine, a negatively charged lipid, is exposed on the platelet membrane following cell stimulation, correlating with the expression of factor VIII receptors. We have explored the importance of the negative electrostatic potential of phosphatidylserine vs chemical moieties of phosphatidylserine for specific membrane binding of factor VIII. Fluorescein-labeled factor VIII bound to membranes containing 15% phosphatidic acid, a negatively charged phospholipid, with low affinity compared to phosphatidylserine-containing membranes. Binding was not specific as it was inhibited by other proteins in plasma. Factor VIII bound to membranes containing 10% phosphatidylserine in spite of a varying net charge provided by 0-15% stearylamine, a positively charged lipid. The soluble phosphatidylserine moiety, O-phospho-L-serine, inhibited factor VIII binding to phosphatidylserine-containing membranes with a Ki of 20 mM, but the stereoisomer, O-phospho-D-serine, was 5-fold less effective. Furthermore, binding of factor VIII to membranes containing synthetic phosphatidyl-D-serine was 5-fold less than binding to membranes containing phosphatidyl-L-serine. Membranes containing synthetic phosphatidyl-L-homoserine, differing from phosphatidylserine by a single methylene, supported high-affinity binding, but it was not specific as factor VIII was displaced by other plasma proteins. O-Phospho-L-serine also inhibited the binding of factor VIII to platelet-derived microparticles with a Ki of 20 mM, and the stereoisomer was 4-fold less effective. These results indicate that membrane binding of factor VIII is mediated by a stereoselective recognition O-phospho-L-serine of phosphatidylserine and that negative electrostatic potential is of lesser importance.

Expedition 8 Crew Interview: Pedro Duque

Science.gov (United States)

2003-01-01

European Space Agency (ESA) astronaut Pedro Duque is interviewed in preparation for his flight to and eight day stay on the International Space Station (ISS) as part of the Cervantes mission. Duque arrived on the ISS with the Expedition 8 crew onboard a Soyuz TMA-3, the seventh Soyuz flight to the station. He departed from the ISS on a Soyuz TMA-2 with the Expedition 7 crew of the ISS. In the video, Duque answers questions on: the goals of his flight; his life and career path; the Columbus Module, which ESA will contribute to the ISS, the ride onboard a Soyuz, and the importance of the ISS.

VIII Olimpíada Brasileira de Astronomia e Astronáutica

Science.gov (United States)

Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria

2007-07-01

Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

Analysis of mutations in the entire coding sequence of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Bidichadani, S.I.; Lanyon, W.G.; Connor, J.M. [Glascow Univ. (United Kingdom)] [and others

1994-09-01

Hemophilia A is a common X-linked recessive disorder of bleeding caused by deleterious mutations in the gene for clotting factor VIII. The large size of the factor VIII gene, the high frequency of de novo mutations and its tissue-specific expression complicate the detection of mutations. We have used a combination of RT-PCR of ectopic factor VIII transcripts and genomic DNA-PCRs to amplify the entire essential sequence of the factor VIII gene. This is followed by chemical mismatch cleavage analysis and direct sequencing in order to facilitate a comprehensive search for mutations. We describe the characterization of nine potentially pathogenic mutations, six of which are novel. In each case, a correlation of the genotype with the observed phenotype is presented. In order to evaluate the pathogenicity of the five missense mutations detected, we have analyzed them for evolutionary sequence conservation and for their involvement of sequence motifs catalogued in the PROSITE database of protein sites and patterns.

Pedro Gutierrez Bueno's Textbooks: Audiences, Teaching Practices and Chemical Revolution

Science.gov (United States)

Sanchez, Jose Ramon Bertomeu; Belmar, Antonio Garcia

2006-01-01

Pedro Gutierrez Bueno wrote two editions of a chemistry textbook between 1788 and 1802. The paper offers a comparative view of both editions taking into account Gutierrez Bueno's biography, his intended audience and the changes related to the so-called chemical revolution. Some conclusions are at odds with common images about scientific…

Avaliação da sensibilidade da goiabeira 'Pedro Sato' ao ozônio

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Regina Maria de Moraes

2011-09-01

Full Text Available O objetivo deste trabalho foi avaliar a sensibilidade da goiabeira 'Pedro Sato' ao ozônio (O3, em comparação à cultivar Paluma, descrita como sensível. Oito plantas de cada cultivar foram submetidas separadamente a ar filtrado e a ar filtrado + O3, cinco horas por dia, durante quatro dias. Foram avaliadas fotossíntese (Asat, injúrias foliares visíveis e concentração de antocianinas e taninos. Plantas das duas cultivares também foram expostas, durante três meses, a condições ambientais em local contaminado por O3, tendo-se avaliado fotossíntese, injúrias foliares e crescimento. Plantas fumigadas com O3 apresentaram redução de Asat e da atividade fotoquímica, além de manifestação de injúrias foliares. 'Paluma' apresentou maior redução de Asat, injúrias foliares mais severas e redução de taninos. Quando exposta ao ambiente contaminado, 'Paluma' apresentou trocas gasosas mais altas, mas apresentou redução de Asat 30 dias antes que 'Pedro Sato'. O crescimento não foi afetado em 'Pedro Sato', cujas injúrias foliares tiveram menor incidência, severidade e precocidade do que em 'Paluma'. A menor taxa de crescimento de 'Paluma' indica maior sensibilidade ao O3. Apesar de responder com menor intensidade ao estresse induzido pelo O3, a cultivar Pedro Sato não pode ser considerada tolerante, pois apresenta danos fotoquímicos, injúrias foliares e alterações nos conteúdos de metabólitos secundários quando exposta a esse poluente.

Lowland riparian herpetofaunas: the San Pedro River in southeastern Arizona

Science.gov (United States)

Philip C. Rosen

2005-01-01

Previous work has shown that southeastern Arizona has a characteristic, high diversity lowland riparian herpetofauna with 62-68 or more species along major stream corridors, and 46-54 species in shorter reaches within single biomes, based on intensive fieldwork and museum record surveys. The San Pedro River supports this characteristic herpetofauna, at least some of...

The vestibulocochlear nerve (VIII).

Science.gov (United States)

Benoudiba, F; Toulgoat, F; Sarrazin, J-L

2013-10-01

The vestibulocochlear nerve (8th cranial nerve) is a sensory nerve. It is made up of two nerves, the cochlear, which transmits sound and the vestibular which controls balance. It is an intracranial nerve which runs from the sensory receptors in the internal ear to the brain stem nuclei and finally to the auditory areas: the post-central gyrus and superior temporal auditory cortex. The most common lesions responsible for damage to VIII are vestibular Schwannomas. This report reviews the anatomy and various investigations of the nerve. Copyright © 2013. Published by Elsevier Masson SAS.

Practical experience and lessons learned through implementation of Appendix VIII performance demonstration requirements

International Nuclear Information System (INIS)

Ashwin, P.J.; Becker, F.L.; Latiolais, C.L.; Spanner, J.C.

1996-01-01

To provide the US nuclear industry with a uniform implementation of the Performance Demonstration requirements within the 1989 edition of ASME Section XI, Appendix VIII, representatives from all US nuclear utilities formed the Performance Demonstration Initiative (PDI). The PDI recognized the potential benefits that Appendix VIII offered the nuclear industry and initiated a proactive approach to implement the requirements. In doing so it was expected that performance demonstration of ultrasonic examination procedures would allow for improvement in the efficiency and credibility of inservice inspection to be realized. Explicit within the performance demonstration requirements of Appendix VIII is the need for a Performance Demonstration Administrator, a difficult requirement to fulfill. Not only must the administrator exhibit the attributes of understanding the demonstration requirements, but also have solid technical knowledge, integrity and be able to interface with the industry at all levels, from operations to regulatory. For the nuclear industry, the EPRI NDE Center is an obvious choice to fulfill this position. This paper provides a brief background of the PDI, a nuclear industry-wide initiative to implement the performance demonstration requirements of Appendix VIII. Even though the consensus approach adopted by the PDI is discussed, the paper's primary objective is to provide examples of the lessons learned by the Center through the specific requirements of Appendix VIII

The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

Directory of Open Access Journals (Sweden)

Caileen M Brison

Full Text Available The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic for hemophilia patients with inhibitor due to its low cross-reactivity; however, the molecular basis for this behavior is poorly understood. In this study, the X-ray crystal structure of the porcine factor VIII C2 domain was determined, and superposition of the human and porcine C2 domains demonstrates that most surface-exposed differences cluster on the face harboring the "non-classical" antibody epitopes. Furthermore, antibody-binding results illustrate that the "classical" 3E6 antibody can bind both the human and porcine C2 domains, although the inhibitory titer to human factor VIII is 41 Bethesda Units (BU/mg IgG versus 0.8 BU/mg IgG to porcine factor VIII, while the non-classical G99 antibody does not bind to the porcine C2 domain nor inhibit porcine factor VIII activity. Further structural analysis of differences between the electrostatic surface potentials suggest that the C2 domain binds to the negatively charged phospholipid surfaces of activated platelets primarily through the 3E6 epitope region. In contrast, the G99 face, which contains residue 2227, should be distal to the membrane surface. Phospholipid binding assays indicate that both porcine and human factor VIII C2 domains bind with comparable affinities, and the human K2227A and K2227E mutants bind to phospholipid surfaces with similar affinities as well. Lastly, the G99 IgG bound to PS-immobilized factor VIII C2 domain with an apparent dissociation constant of 15.5 nM, whereas 3E6 antibody binding to PS-bound C2 domain was not observed.

46 CFR 501.41 - Public requests for information and decisions.

Science.gov (United States)

2010-10-01

... Certification and Licensing; (vi) Bureau of Trade Analysis; (vii) Bureau of Enforcement; and (viii) Area... Representatives are as follows. Further information on Area Representatives, including Internet e-mail addresses... South Beacon Street, Room 320, San Pedro, CA 90733-0230. New Orleans Area Representative, P.O. Box 700...

PEDAGOGUES AND TAES AT COLÉGIO PEDRO II - Historical and Identitarian Notes.

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Alessandra Pio

2016-07-01

Full Text Available The article aims at relating the process of development of a professional identity among pedagogues in Brazil, the historical path of Pedagogy as a course, the educational legislation in Brazil and Colégio Pedro II. Colégio Pedro II is an educational institution of excellence, whose history, of national importance, has dealt very little with working relationships outside the classroom. For this reason, the objective of this study is to promote discussions which, regarding professional identities, take into consideration not only the subject, but also the group to which they belong. In terms of theoretical support, the author relies on the sociological approach discussed by Dubar (2005 and the analysis of the history of pedagogy courses carried out by Silva (2006. In addition, other relevant instances are public selection notices for admission to Colégio Pedro II from 1946 to 2015, academic studies upon the theme and responses from entities and professionals in the field of Education upon the pedagogy course programmes. The author takes into account that identities of both the pedagogue and the educational matters technician (TAE are entangled at institutional level, which shows that the institution is still unsure of what to require and demand from both professionals. Although these educational matters professionals have licentiate degrees in other areas, it is still expected at institutional level that they act as specialists in education (pedagogue.

Evaluación de la gestión en el Parque Regional de las Salinas y Arenales de San Pedro del Pinatar (Murcia

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Gustavo A. Ballesteros Pelegrín

2014-01-01

Full Text Available El Parque Regional de las Salinas y Arenales de San Pedro del Pinatar es un territorio multifuncional desde el punto de vista social, económico y ambiental, donde es imposible separar y, por tanto gestionar de forma independiente, las tramas paisajísticas y ecológicas de las tramas socioeconómicas. Para su gestión, la Administración se apoya en el Plan de Ordenación de los Recursos Naturales aprobado en 1995, que sin embargo ha sido ejecutado en el 50 % de su articulado. Se desarrollan diversas iniciativas de conservación de fauna y flora silvestre, recogida de residuos sólidos, una adecuada información al visitante y mejora del conocimiento de los diferentes elementos de los espacios protegido. Sin embargo la participación social es escasa, la Junta Rectora se ha reunido en solo cuatro ocasiones, la última en 2001, se han producido desarrollos urbanísticos en la periferia del Parque que producen deterioro paisajístico y se han desarrollado una serie de infraestructuras que han reducido en unas 7 hectáreas la superficie protegida.

The decline of Dom Pedro II's empire and health: neurophatogenic implications O declínio do império e da saúde de Dom Pedro II: implicações neuropatogênicas

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Marleide da Mota Gomes

2007-12-01

Full Text Available The main objective of this paper is to know the medical doctors of the Emperor, the preconized treatment, and the knowledge about diabetes at that time, its repercussions on the Emperor's nervous system, and the related political implications. A narrative revision was made, based on primary and secondary sources. Dom Pedro II was examined by the aristocracy of the medicine at the time, especially Jean-Martin Charcot, amongst the doctors of international reputation, and Cláudio Velho da Motta Maia, amongst the Brazilian doctors. Charcot diagnosed in the Monarch: mental stress, diabetic neuropathy, and a cerebral vascular lesion, probably a stroke, that he differentiated from other vascular obliterations elsewhere. He demonstrated his knowledge about diabetic neuropathy, possible topographical alternatives to justify the urinary incontinence, and Dom Pedro's weakness in the legs. Throughout his illness, Dom Pedro II presented others manifestations that contributed to his physical fragility, and that, certainly too, to his political decline, deposition and the proclamation of the Brazilian Republic.O objetivo principal deste artigo é conhecer os médicos do Imperador, o tratamento preconizado e o conhecimento da ocasião sobre o diabetes, principalmente sobre suas repercussões no sistema nervoso do imperador e suas implicações políticas. Isso foi feito por uma revisão narrativa, baseado em fontes primárias e secundárias. Dom Pedro II foi examinado na ocasião pela aristocracia da medicina, a ressaltar Jean-Martin Charcot, dentre os médicos de reputação internacional, e Cláudio Velho da Motta Maia, dentre os brasileiros. Charcot diagnosticou no Monarca, além de tensão mental, neuropatia diabética e quadro vascular cerebral que ele diferenciou de outras obliterações vasculares em localizações diversas. Ele demonstrou o seu conhecimento sobre a neuropatia diabética, possíveis alternativas topográficas para justificar a incontin

Igor Zabel 14. VIII 1958 - 23. VII 2005

Index Scriptorium Estoniae

2005-01-01

Igor Zabel oli Ida-Euroopa tuntumaid kunstiteoreetikuid ja kuraatoreid. Töötas 1986. aastast Ljubljana moodsa kunsti muuseumi kuraatorina. 9. VIII avatakse seal viimane I. Zabeli kureeritud näitus "Territories, Identities, Nets-Slovene Art 1995-2005"

Home therapy with continuous infusion of factor VIII after minor surgery or serious haemorrhage.

Science.gov (United States)

Varon, D; Schulman, S; Bashari, D; Martinowitz, U

1996-10-01

Administration of factor VIII (F VIII) concentrates by continuous infusion is now routinely used at several haemophilia centers but almost exclusively for hospitalized patients. We evaluated various aspects of home therapy with continuous infusion of an immunoaffinity purified F VIII concentrate (Monoclate P®, Armour) in patients who would normally have been treated with high doses in bolus injections or with continuous infusion as in-patients. Twenty haemophilia A patients, eight after minor surgery and 12 for serious haemorrhage, received continuous infusion with undiluted F VIII by a minipump for a mean of 0.9 days in the hospital, followed by 3.3 days at home. Infusion bags were exchanged every 2.5 days. No haemorrhagic complications occurred, and five haemorrhages that had been resistant to treatment with bolus injections responded promptly to the continuous infusion. There were no technical problems and patient compliance and acceptance was good. We find this mode of therapy safe, efficacious and convenient for the patients as well as for the staff.

Tamarisk and river restoration along the San Pedro and Gila Rivers

Science.gov (United States)

Juliet Stromberg; Sharon Lite; Charles Paradzick

2005-01-01

The abundance of tamarisk (Tamarix ramosissima and related species) along the San Pedro and Gila River flood plains varies with differences in stream flow regimes. Tamarisk abundance, relative to Fremont cottonwood and Goodding willow, is greater at sites with more intermittent stream flows and deeper and more fluctuating ground-water levels....

Pedro de Castañeda: su pintura para el refectorio del Colegio Mayor de San Ildefonso (1553

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González Ramos, Roberto

2003-09-01

Full Text Available El pintor Pedro de Castañeda es un artista poco conocido, activo en la zona de Alcalá de Henares en las décadas centrales del siglo XVI. Se sabe que junto a su hijo Juan fue colaborador del entallador y traductor de Vitruvio Miguel de Urrea. Pedro de Castañeda pintó un cirial que había tallado Urrea para la iglesia parroquial de Camarma de Esteruelas, trabajo por el que ambos cobraron cierta cantidad en 1540, y en 1550 colaboró con ese entallador y con Claudio de Arciniega, ayudado por Juan, en la obra de los retablos colaterales de la iglesia de Daganzo de Arriba (perdidos, realizando su pintura. Parece que se trata del mismo artista el Pedro Castañeda que se documenta trabajando en la zona de Segovia, concretamente en dos retablos para la iglesia de Cascajares del Fresno. Falleció en 1557…

INTERVENCIÓN ARQUEOMAGNÉTICA DEL HORNO DE LA HACIENDA SAN PEDRO CHOLUL (MÉRIDA, YUCATÁN (Archaeomagnetic Dating of a Kiln from the San Pedro Cholul Hacienda (Merida, Yucatan

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Héctor Hernández Álvarez

2017-12-01

Full Text Available En el presente trabajo se reportan los resultados de un estudio arqueomagnético realizado en un horno para la quema de cal encontrado en la hacienda henequenera de San Pedro Cholul, localizada al noroeste de la ciudad de Mérida en el estado de Yucatán, México. La finalidad del estudio es establecer una cronología confiable y analizar las posibles consecuencias sociales, económicas y ambientales de este asentamiento, el cual existió posiblemente desde mediados del siglo XIX hasta los años sesenta del siglo pasado. Para la determinación de la cronología, se utilizó el método de datación arqueomagnética a estructuras pirotecnológicas de estas características. Las muestras estudiadas provienen de rocas y ladrillos del horno y arrojan una edad entre 1835 y 1896, la cual concuerda con la información histórica disponible y se interpreta como el periodo de producción más importante de la región. ENGLISH: This paper presents the results of an archaeomagnetic study carried out on a lime burning kiln at the henequen hacienda of San Pedro Cholul (northwest of the city of Merida in the state of Yucatan, Mexico. The purpose of the study is to establish a reliable chronology and to estimate the possible social, economic and environmental implications of this settlement, which may have existed from the middle of the nineteenth century until the 1960s. Archaeomagnetic dating was carried out on samples obtained from rocks and bricks from the kiln and give an age between 1835 and 1896. This date range agrees with available historical information and is interpreted as the most important production period of the region.

Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia a

NARCIS (Netherlands)

C.L. Eckhardt (Corien); A.S. van Velzen (Alice); M.A.D. Peters (Marjolein); J. Astermark (Jan); P.P. Brons; G. Castaman (Giancarlo); M.H. Cnossen (Marjon); N. Dors (N.); C. Escuriola-Ettingshausen (Carmen); K. Hamulyák (K.); D.P. Hart (Daniel); C.R.M. Hay (Charles R.); S. Haya (Saturnino); W.L. van Heerde; C. Hermans (Cédric); M. Holmström (Margareta); V. Jimenez-Yuste (Victor); R.D. Keenan (Russell); R. Klamroth (Robert); B.A.P. Laros-Van Gorkom (Britta); F.W.G. Leebeek (Frank); R. Liesner (Ri); A. Mäkipernaa (Anne); C. Male (Christoph); E.P. Mauser-Bunschoten (Eveline); M.G. Mazzucconi (Maria); S. McRae (Simon); K. Meijer (K.); M. Mitchell (Michael); M. Morfini (Massimo); M.R. Nijziel (Marten); J. Oldenburg (Jan); K. Peerlinck; P. Petrini (Pia); H. Platokouki (Helena); S.E. Reitter-Pfoertner (Sylvia); E. Santagostino (Elena); P. Schinco (Piercarla); F.J.W. Smiers (Frans); K.D. Siegmund (Kimberly); A. Tagliaferri (Annarita); T.T. Yee (Thynn); P.W. Kamphuisen (Pieter Willem); J.G. van der Bom (Anske); K. Fijnvandraat

2013-01-01

textabstractNeutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into

Characterization of five partial deletions of the factor VIII gene

International Nuclear Information System (INIS)

Youssoufian, H.; Antonarakis, S.E.; Aronis, S.; Tsiftis, G.; Phillips, D.G.; Kazazian, H.H. Jr.

1987-01-01

Hemophilia A is an X-linked disorder of coagulation caused by a deficiency of factor VIII. By using cloned DNA probes, the authors have characterized the following five different partial deletions of the factor VIII gene from a panel of 83 patients with hemophilia A: (i) a 7-kilobase (kb) deletion that eliminates exon 6; (ii) a 2.5-kb deletion that eliminates 5' sequences of exon 14; (iii) a deletion of at least 7 kb that eliminates exons 24 and 25; (iv) a deletion of at least 16 kb that eliminates exons 23-25; and (v) a 5.5-kb deletion that eliminates exon 22. The first four deletions are associated with severe hemophilia A. By contrast, the last deletion is associated with moderate disease, possibly because of in-frame splicing from adjacent exons. None of those patients with partial gene deletions had circulating inhibitors to factor VIII. One deletion occurred de novo in a germ cell of the maternal grandmother, while a second deletion occurred in a germ cell of the maternal grandfather. These observations demonstrate that de novo deletions of X-linked genes can occur in either male or female gametes

Apología y censura: posibles autores de las crónicas favorables a Pedro I de Castilla

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González de Fauve, María Estela

2006-06-01

Full Text Available

The present historiography considers that from the times of Pedro I of Castile, favorable stories to this king must have existed which were destroyed after the triumph of the Trastámara dynasty, only interested in making sure a negative picure of the ";Cruel"; king was shown. In this work we have analyzed possible authors of the chronicles called ";true"; versus Ayala's ";false";, as well as the Relación de la vida del Rey D. Pedro attributed to Gracia Dei. The research allows us to conclude that various characteristics attributed to these characters, as well as the authorship of the chronicles they are adscripted to, are part of an advertising campaign started in the sixteenth century by one branch of the Castilla lineage that looks for the reaffirmation as legitimate descendants of Pedro I.

Comparison of Public Perception in Desert and Rainy Regions of Chile Regarding the Reuse of Treated Sewage Water

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Daniela Segura

2018-03-01

Full Text Available The objective of this study was to compare the public perception in desert and rainy regions of Chile regarding the reuse of treated sewage water. The methodology of this study consisted of applying a survey to the communities of San Pedro de Atacama (desert region and Hualqui (rainy region to identify attitudes about the reuse of sewage water. The survey was applied directly to men and women, 18 to 90 years old, who were living in the studied communities. The results indicate that inhabitants of San Pedro de Atacama (desert region were aware of the state of their water resources, with 86% being aware that there are water shortages during some part of the year. In contrast, only 55% of residents in Hualqui (rainy region were aware of water shortages. With respect of the reuse of treated sewage water, 47% of respondents in San Pedro de Atacama understood the concept, as compared to 27% in Hualqui. There was more acceptance of using treated sewage water for non-potable purposes than as drinking water.

Analysis of the 4d7 (4f + 6p) and 4p54d9 configurations of Sn VII, Sb VIII and Te IX

International Nuclear Information System (INIS)

Azarov, V.I.; Joshi, Y.N.; Churilov, S.S.; Ryabtsev, A.N.

1994-01-01

The spectra of tin, antimony and tellerium were photographed in the 120-200 A region on 10.7 m and 3 m grazing incidence spectrographs using a triggered spark source. The 4d 8 -4d 7 (4f + 6p) + 4p 5 4d 9 transitions of Sn VII, Sb VIII and Te IX were investigated. In the Sn VII spectrum 109 new lines were classified in the 152-192 A region and 34 new levels were established, in the Sb VIII spectrum 78 new lines were classified in the 138-158 A region and 21 new levels were established, and in the Te IX 76 new lines were classified in the 121-139 A region and 21 new levels were established. Strong configuration interaction among the 4d 7 (np + mf), and 4p 5 4d 9 (n = 5, 6; m = 4, 5) configurations was observed. Least-squares-fitting (LSF) parametric calculations involving configuration interaction were carried out to interpret the observed spectra. (orig.)

Pedro Calderón de la Barca, Autos sacramentales - Francisco de Quevedo, Prosa satírica

OpenAIRE

Plata, Fernando

2011-01-01

Reseñas de Pedro Calderón de la Barca, Autos sacramentales. El divino Jasón. El gran mercado del Mundo. El gran teatro del Mundo. La viña del Señor, ed. I. Arellano, Homo Legens (Bibliotheca Homolegens, 50), Madrid, 2010, 406 pp. ISBN: 978-84-92518-54-8 y Francisco de Quevedo, Prosa satírica, ed. I. Arellano, Homo Legens (Bibliotheca Homolegens, 58), Madrid, 2011, 206 pp. ISBN: 978-84-92518-69-2. Reviews of Pedro Calderón de la Barca, Autos sacramentales. El divino Jasón. El gran mercado d...

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Energy Technology Data Exchange (ETDEWEB)

Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)

2008-06-03

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Energy Technology Data Exchange (ETDEWEB)

Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.

2008-01-01

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Henry VIII, McLeod syndrome and Jacquetta's curse.

Science.gov (United States)

Stride, P; Lopes Floro, K

2013-01-01

The mental decline of King Henry VIII from being a jovial, charismatic and athletic young man into an increasingly paranoid, brutal tyrant in later life, ever more concerned at his lack of one or more male heirs, has attracted many medical diagnostic theories. Previous hypotheses have included diabetes, syphilis and hypothyroidism, among others. However, these inadequately explain Henry's failure to produce a male heir, despite multiple pairings. The latest postulated diagnoses for Henry are the coexistence of both Kell blood group antigenicity (possibly inherited from Jacquetta Woodville, Henry's maternal great grandmother) causing related impaired fertility, and McLeod syndrome, causing psychotic changes. As the mutated McLeod protein of the syndrome significantly reduces the expression, effectively inactivating the Kell antigen, we critically review this theory, examining in detail the pathophysiology of these conditions and assessing the genealogy of Henry VIII and its effect in subsequent generations.

Evidence for the formation of sodium hassate(VIII)

International Nuclear Information System (INIS)

Zweidorf, A. von; Angert, R.; Bruechle, W.; Buerger, S.; Eberhardt, K.; Eichler, R.; Hummrich, H.; Jaeger, E.; Kling, H.O.; Kratz, J.V.; Kuczewski, B.; Langrock, G.; Mendel, M.; Rieth, U.; Schaedel, M.; Schausten, B.; Schimpf, E.; Thoerle, P.; Trautmann, N.; Tsukada, K.; Wiehl, N.; Wirth, G.

2004-01-01

Hassium, element 108, was produced in the fusion reaction between 26 Mg and 248 Cm. The hassium recoils were oxidized in-situ to a highly volatile oxide, presumably HsO 4 , and were transported in a mixture of He and O 2 to a deposition and detection system. The latter consisted of 16 silicon PIN-photodiodes facing a layer of NaOH, which served, in the presence of a certain partial pressure of water in the transport gas, as reactive surface for the deposition of the volatile tetroxides. Six correlated α-decay chains of Hs were detected in the first 5 detectors centred around detection position 3. In analogy to OsO 4 , which forms Na 2 [OsO 4 (OH) 2 ], an osmate(VIII), with aqueous NaOH, HsO 4 presumably was deposited as Na 2 [HsO 4 (OH) 2 ], a hassate(VIII). (orig.)

The spectrum and term system of S VIII

International Nuclear Information System (INIS)

Bengtsson, P.; Jupen, C.; Engstroem, L.; Redfors, A.; Westerlind, M.

1993-01-01

The spectrum of seven times ionized sulfur, S VIII, has been observed in the wavelength range 50-1200 A. Both beam-foil and laser-produced plasma light sources have been used. 71 new lines representing the transitions 2p 5 -2p 4 3d, 2p 4 3s-3p, 3p-3d, 3d-4f, 4f-5g and 5g-6h have been identified and 100 energy levels, of which 46 are new, are now accurately established. The spectral analysis is supported by isoelectronic comparisons along the F I-sequence and by parametric least-squares fits of Slater integrals to the observed levels. The ionization potential in S VIII is determined to 2 651 899 ± 60 cm -1 and estimated ionization energies are derived for the isoelectronic elements between F I and Ar X. (orig.)

Purification and characterization of factor VIII 1,689-Cys: a nonfunctional cofactor occurring in a patient with severe hemophilia A.

Science.gov (United States)

O'Brien, D P; Tuddenham, E G

1989-06-01

We have purified the factor VIII from a CRM+ Hemophilia A plasma (90 U/dL VIII:Ag but 0 U/dL VIII:C) and analyzed the protein before and after thrombin activation by Western blotting with monoclonal antibodies (MoAbs). Normal or patient citrated plasma was ultracentrifuged, cryo-ethanol-precipitated and chromatographed on Sepharose 6B. The void volume fractions were reduced and subjected to ion exchange chromatography yielding material of specific activity approximately 1,000 U/mg protein (VIII:C or VIII:Ag). Factor VIII purified in this way from normal plasma is fully activatable by thrombin with proteolytic fragmentation as previously described by F. Rotblat et al (Biochemistry 24: 4294, 1985). Factor VIII 1,689-Cys has the normal distribution of factor VIII light and heavy chains prior to thrombin activation. After exposure to thrombin the heavy chain polypeptides were fully proteolysed but the light chain was totally resistant to cleavage. This is consistent with the demonstration in the patient's leucocyte DNA of a C to T transition in codon 1,689 converting Arg to Cys at the light chain thrombin cleavage site as previously described by J. Gitschier et al (Blood 72:1022, 1988). Uncleaved light chain of Factor VIII 1,689-Cys is not released from von Willebrand factor (vWF) by thrombin, but this is not the sole cause of the functional defect since the protein purified free of vWF has no coagulant activity. We conclude that the functional defect in factor VIII 1,689-Cys is a consequence of failure to release the acidic peptide from the light chain upon thrombin activation.

Partamona nigrilabris Pedro & Camargo, 2003, um novo sinônimo de P. nigrior (Cockerell, 1925 (Hymenoptera, Apidae Partamona nigrilabris Pedro & Camargo, 2003, a new synonym of P. nigrior (Cockerell, 1925 (Hymenoptera, Apidae

Directory of Open Access Journals (Sweden)

João M. F. Camargo

2003-01-01

Full Text Available P. nigrilabris was described based on specimens wrongly labelled as from "Salvador-BA, Brasil". It is considered as a new synonym: Partamona nigrior (Cockerell, 1925 = P. nigrilabris Pedro & Camargo, 2003, syn. nov.

Irradiation and passive modified atmosphere on the post-harvest quality of guavas ‘Pedro Sato’. = Irradiação e atmosfera modificada passiva na qualidade pós-colheita de goiabas ‘Pedro Sato’ .

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André José de Campos

2011-12-01

Full Text Available The aim of this study was to evaluate the effect of gamma radiation associated with modified atmosphere on postharvest quality of guavas ‘Pedro Sato’. It was used guavas from the region of Vista Alegre do Alto/São Paulo/Brazil. After harvest, the fruits were immediately transported to the Fruit and Vegetables Laboratory from the Agroindustrial Management and Technology Department, Agronomic Sciences College - UNESP - Botucatu / SP, where they were kept at 10 ° C and 90-95% RH in cold storage, for 28 days. It was used the randomized design, with factorial scheme 5 x 5, three repetitions. The first factor consisted of the following effects: control 1 (without package or irradiation, control 2 (polystyrene package/PS + package low density polyethylene/LDPE and without irradiation, treatment 1 (PS + LDPE and 0.2 kGy , treatment 2 (PS + LDPE and 0.6 kGy and treatment 3 (PS + LDPE and 1.0 kGy. The second factor consisted of the evaluation periods: 0, 7, 14, 21 and 28 days. The analyses were: firmness, soluble solids (SS, titratable acidity (TA, maturity index, pH, respiration rate. Concluded that high doses of irradiation promoted a negative effect on physical-chemical characteristics of guava ‘Pedro Sato’, verifying that only the lowest dose associated with modified atmosphere provided fruits with higher quality and acceptability, due to higher maturation rate and soluble solids obtained. Regarding the days of analysis, there were no positive effect of the treatments during storage, where only the early days promoted better values for the variables studied.

40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

Science.gov (United States)

2010-07-01

... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Pt. 266, App. VIII Appendix VIII to Part 266... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Organic Compounds for Which Residues...

40 CFR Appendix Viii to Part 268 - LDR Effective Dates of Injected Prohibited Hazardous Wastes

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Injected Prohibited Hazardous Wastes VIII Appendix VIII to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION... to Part 268—LDR Effective Dates of Injected Prohibited Hazardous Wastes National Capacity LDR...

Flora of the San Pedro Riparian National Conservation Area, Cochise County, Arizona

Science.gov (United States)

Elizabeth Makings

2005-01-01

The flora of the San Pedro Riparian National Conservation Area (SPRNCA) consists of 618 taxa from 92 families, including a new species of Eriogonum and four new State records. The vegetation communities include Chihuahuan Desertscrub, cottonwood-willow riparian corridors, mesquite terraces, sacaton grasslands, rocky outcrops, and cienegas. Species...

Structural characterization of the novel aminoglycoside phosphotransferase AphVIII from Streptomyces rimosus with enzymatic activity modulated by phosphorylation

Energy Technology Data Exchange (ETDEWEB)

Boyko, Konstantin M., E-mail: kmb@inbi.ras.ru [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Gorbacheva, Marina A.; Korzhenevskiy, Dmitry A. [National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Alekseeva, Maria G.; Mavletova, Dilara A.; Zakharevich, Natalia V.; Elizarov, Sergey M.; Rudakova, Natalia N.; Danilenko, Valery N. [Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str. 3, Moscow, 119333 (Russian Federation); Popov, Vladimir O. [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation)

2016-09-02

Aminoglycoside phosphotransferases represent a broad class of enzymes that promote bacterial resistance to aminoglycoside antibiotics via the phosphorylation of hydroxyl groups in the latter. Here we report the spatial structure of the 3′-aminoglycoside phosphotransferase of novel VIII class (AphVIII) solved by X-ray diffraction method with a resolution of 2.15 Å. Deep analysis of APHVIII structure and its comparison with known structures of aminoglycoside phosphotransferases of various types reveals that AphVIII has a typical two-domain fold and, however, possesses some unique characteristics that distinguish the enzyme from its known homologues. The most important difference is the presence of the activation loop with unique Ser146 residue. We demonstrate that in the apo-state of the enzyme the activation loop does not interact with other parts of the enzyme and seems to adopt catalytically competent state only after substrate binding. - Highlights: • 3D structure of the novel aminoglycoside phosphotransferase AphVIII was obtained. • AphVIII activation loop is clearly identified in the electron density. • AphVIII has some unique structural features in its substrate C-ring binding pocket.

Hemodialysis in a patient with severe hemophilia A and factor VIII inhibitor.

Science.gov (United States)

Gopalakrishnan, Natarajan; Usha, Thiruvengadam; Thopalan, Balasubramaniyan; Dhanapriya, Jeyachandran; Dineshkumar, Thanigachalam; Thirumalvalavan, Kaliaperumal; Sakthirajan, Ramanathan

2016-10-01

Hemophilia A is a hereditary X-linked recessive disease caused by mutations in the gene encoding factor VIII (FVIII), occurring in 1 out of 10,000 persons. Life expectancy and quality of life have dramatically improved recently in patients with hemophilia. Chronic kidney disease and need for renal replacement therapy in these patients are rare. The development of inhibitors to FVIII is the most serious complication of hemophilia and makes treatment of bleeds very challenging. We describe here a 28-year-old male patient with severe hemophilia A with presence of factor VIII inhibitor, who had end stage renal disease. Central venous access device was inserted along with infusion of factor eight inhibitor bypass activity before and after the procedure. He is currently on thrice weekly hemodialysis and doing well for 6 months without bleeding episodes. To our knowledge, hemophilia A with factor VIII inhibitor managed with hemodialysis has not been reported so far. © 2016 International Society for Hemodialysis.

Quaternary Geochronology, Paleontology, and Archaeology of the Upper San Pedro River Valley, Sonora, Mexico

Science.gov (United States)

Gaines, E. P.

2013-12-01

This poster presents the results of multi-disciplinary investigations of the preservation and extent of Quaternary fossil-bearing strata in the San Pedro River Valley in Sonora, Mexico. Geologic deposits in the portions of the San Pedro Valley in southern Arizona contain one of the best late Cenozoic fossil records known in North America and the best record of early humans and extinct mammals on the continent. The basin in the U.S. is one of the type locations for the Blancan Land Mammal Age. Hemiphilian and Irvingtonian fossils are common. Rancholabrean remains are widespread. Strata in the valley adjacent to the international border with Mexico have yielded the densest concentration of archaeological mammoth-kill sites known in the western hemisphere. Despite more than 60 years of research in the U.S., however, and the fact that over one third of the San Pedro River lies south of the international boundary, little has been known about the late Cenozoic geology of the valley in Mexico. The study reported here utilized extensive field survey, archaeological documentation, paleontological excavations, stratigraphic mapping and alluvial geochronology to determine the nature and extent of Quaternary fossil-bearing deposits in the portions of the San Pedro Valley in Sonora, Mexico. The results demonstrate that the Plio-Pleistocene fossil -bearing formations known from the valley in Arizona extend into the uppermost reaches of the valley in Mexico. Several new fossil sites were discovered that yielded the remains of Camelids, Equus, Mammuthus, and other Proboscidean species. Late Pleistocene archaeological remains were found on the surface of the surrounding uplands. AMS radiocarbon dating demonstrates the widespread preservation of middle- to late- Holocene deposits. However, the late Pleistocene deposits that contain the archaeological mammoth-kill sites in Arizona are absent in the valley in Mexico, and are now known to be restricted to relatively small portions of

Spectrophotometric determination of hydrogen peroxide with osmium(VIII) and m-carboxyphenylfluorone.

Science.gov (United States)

Hoshino, Mitsuru; Kamino, Shinichiro; Doi, Mitsunobu; Takada, Shingo; Mitani, Shota; Yanagihara, Rika; Asano, Mamiko; Yamaguchi, Takako; Fujita, Yoshikazu

2014-01-03

Spectrophotometric determination of hydrogen peroxide was accomplished with osmium(VIII) and m-carboxyphenylfluorone (MCPF) in the presence of cetyltrimethylammonium chloride (CTAC). In the determination of hydrogen peroxide based on the fading of the color of osmium(VIII)-MCPF complex, Beer's law was obeyed in the range 20-406 ng mL(-1), with an effective molar absorption coefficient (at 580 nm) of 5.21×10(4) L mol(-1) cm(-1) and a relative standard deviation of 0.33% (n=6). Further, we performed the characterization of MCPF and obtained the crystal structure. Copyright © 2013 Elsevier B.V. All rights reserved.

Silence, Metaperformance, and Communication in Pedro Almodóvar's "Hable con ella"

Science.gov (United States)

Fellie, Maria C.

2016-01-01

Many scenes in Pedro Almodóvar's "Hable con ella" (2002) include shots of metaperformances such as silent films, dances, television shows, concerts, and bullfights. Spectators often observe passive characters who are in turn observing. By presenting these performances within cinematic performance, Almodóvar highlights our role as viewers…

Mejora de los procesos de beneficio y extracción de minerales auroargentíferos del asentamiento minero de San Pedro Frío, Colombia

OpenAIRE

Yáñez Traslaviña, J. J.; Vargas Ávila, M. A.; García Páez, I. H.; Pedraza Rosas, J. E.

2005-01-01

The San Pedro Frio district mining, Colombia, is a rich region producing gold-silver ores. Nowadays, the extraction processes used are amalgamation, percolation cyanidation and precipitation with zinc wood. Due to the ignorance of the ore characteristics, gold and silver treatment processes are inadequate and not efficient In addition the inappropriate use of mercury and cyanide cause environmental contamination. In this research the ore characterization was carried out obtaining fundamental ...

Improvements mineral dressing and extraction processes of gold-silver ores from San Pedro Frio Mining District, Colombia; Mejora de los procesos de beneficio y extraccion de minerales auroargentiferos del asentamiento minero de San Pedro Frio, Colombia

Energy Technology Data Exchange (ETDEWEB)

Yanez Traslavina, J. J.; Vargas Avila, M. A.; Garcia Paez, I. H.; Pedraza Rosas, J. E.

2005-07-01

The San Pedro Frio district mining, Colombia, is a rich region production gold-silver ores. Nowadays, the extraction processes used are amalgamation, percolation cyanidation and precipitation with zinc wood. Due to the ignorance of the ore characteristics, gold and silver treatment processes are inadequate and not efficient. In addition the inappropriate use of mercury and cyanide cause environmental contamination. In this research the ore characterization was carried out obtained fundamental parameters for the technical selection of more efficient gold and silver extraction processes. Experimental work was addressed to the study of both processes the agitation cyanidation and the adsorption on activated carbon in pulp. As a final result proposed a flowsheet to improve the precious metals recovery and reduce the environment contamination. (Author)

A pedagogia da ilustração e os guarani-missioneiros no Rio Grande de São Pedro

Directory of Open Access Journals (Sweden)

Protásio Paulo Langer

2012-07-01

Full Text Available  O presente trabalho visa abordar o projeto pedagógico do iluminismo português imposto aos guaranis provenientes dos Sete Povos das Missões e estabelecidos na aldeia de Nossa Senhora dos Anjos, entre 1762 e 1801. Consideramos o tema relevante não só por suscitar problemas relativos aos primórdios da implantação da educação oficial no Rio Grande do Sul, mas também pelos resultados obtidos com o programa civilizatório pombalino que objetivava a substituição cultural dos guarani-missioneiros no Rio Grande de São Pedro. Palavras-chave: guarani-missioneiros, iluminismo, Rio Grande de São Pedro. Abstract This paper aims to approach the pedagogical project based on the portuguese iluminism which was imposed upon the Guarani indians of the Sete Povos das Missões (the Seven Peoples of the Missions that lived in the aldeia Nossa Senhora dos Anjos (Our Lady of the Angel's village between 1762 and 1801. This subject is relevant because it raises problems related to the early implementation of the official education in Rio Grande do Sul, as wel as the results obtained through the civilizatory program devised by marquês de Pombal which intended to promote the westernization of the Guarani indians in the Province of the Rio Grande de São Pedro. Keywords:  Guarani indians, iluminism, Rio Grande de São Pedro.

Factor VIII-associated antigen in human lymphatic endothelium.

Science.gov (United States)

Nagle, R B; Witte, M H; Martinez, A P; Witte, C L; Hendrix, M J; Way, D; Reed, K

1987-03-01

Lymphatic vascular endothelium both on tissue section and in culture exhibits positivity for Factor VIII-associated antigen although staining is generally less intense and more spotty than in comparable blood vascular endothelium. Lymphatic endothelium also exhibits Weibel-Palade bodies. Neither marker, therefore, reliably distinguishes blood vascular endothelium from lymphatic endothelium.

X-ray spectral line coincidences between fluorine VIII (and IX) and transition metal lines

International Nuclear Information System (INIS)

Charatis, G.; Rockett, P.D.; Burkhalter, P.G.

1983-01-01

X-ray spectroscopy was performed in the 12 to 15 A region, recording L-shell lines from selected laser-irradiated transition metals. Line coincidences and near coincidences were identified between Fe, Cr, Mn, and Ni L-spectra, and F VIII and F IX K-shell lines. Wavelengths were determined to accuracies of 1 to 3 mA and will be utilized in selecting potential pumping candidates in future x-ray lasing schemes. High-resolution x-ray spectra were collected under controlled illumination and target conditions using 1.05 μm and 0.527 μm laser excitation with the KMS CHROMA laser

Minería, conflicto y mediadores locales: Minera San Xavier en Cerro de San Pedro, México Mineira, conflito e mediadores locais: Minera San Xavier em Cerro de San Pedro Mining, conflict and local brokers: Minera San Xavier in Cerro de San Pedro

Directory of Open Access Journals (Sweden)

Hernán Horacio Schiaffini

2011-12-01

Full Text Available Este trabajo indaga en las instancias de mediación que intervienen en la articulación de procesos económicos de gran escala y su puesta en práctica local. Basándonos en el conflicto que se produjo en el Municipio de Cerro de San Pedro (San Luis Potosí, México entre la empresa Minera San Xavier y el Frente Amplio Opositor (FAO a la misma, aplicamos el método etnográfico con el objetivo de describir las estructuras locales de mediación política y analizar sus prácticas y racionalidad. Intentamos demostrar así la importancia de los factores políticos locales en las vinculaciones entre estado, empresa y población.Este trabalho indaga nas instâncias de mediação que intervêm em processos econômicos de grande escala e sua posta em prática local. Baseando-nos no conflito no Cerro de San Pedro (San Luis Potosí, México entre a empresa Minera San Xavier e a Frente Amplio Opositor (FAO aplicamos o método etnográfico pra descrever as estruturas de mediação política locais e analisar suas práticas e racionalidade. Tenta-se demonstrar assim a importância dos fatores políticos locais nas vinculações entre estado, empresa e população.This paper investigates in instances of mediation involved in large-scale economic processes and local implementation. Analyzing the conflict in Cerro de San Pedro (San Luis Potosí, México among San Xavier mining company and the Frente Amplio Opositor (FAO, it applies an ethnographic approach to describe the local structures of political mediation and its practices and rationality. The work shows the relevance of local factors in the relationships between State, company and people.

Performance: travestismos y política en las crónicas de Pedro Lemebel

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Regina Vanesa Cellino

2015-08-01

Full Text Available En este trabajo se indagará sobre la relación que existe entre las crónicas urbanas de Pedro Lemebel, La esquina es mi corazón (1995 y Loco afán. Crónicas de sidario (1996, en el contexto de la posdictadura chilena, y su participación en las performances de Las Yeguas del Apocalipsis, a las que consideramos una articulación entre cuerpo, política y teatralidad. Este texto parte de las siguientes preguntas: ¿Qué afinidad/es hay entre las crónicas literarias de Lemebel y las performances de Las Yeguas del Apocalipsis? ¿Qué relación existe entre el cuerpo, la homosexualidad, el travestismo y la performance? ¿Cómo se manifiesta ese vínculo en las crónicas de Pedro Lemebel? 

La melancolía en la obra de Pedro Gatell, cirujano y marino ilustrado

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Peset, Jose Luis

2014-06-01

Full Text Available Melancholy is an emotion that has been in fashion from the Renaissance until now. During the Enlightenment, human reason was accompanied by strong feelings preparing for Romanticism. A prominent personality in this field was Pedro Gatell, naval surgeon and untiring writer. Throughout his novels and moral writings he shows the main developments coming from the experience of melancholy and its interpretation.La melancolía es una emoción de moda desde el Renacimiento hasta hoy, también en la Ilustración la razón se vio acompañada de fuertes sentimientos que anunciaban el Romanticismo. Personaje destacado en este terreno es Pedro Gatell, cirujano naval e infatigable escritor. En sus novelas y textos morales muestra las principales novedades que surgen en la vivencia melancólica y en su comprensión.

ANÁLISE DA EFETIVIDADE SOCIOECONÔMICA DO PRODECER III NO MUNICÍPIO DE PEDRO AFONSO, TOCANTINS SOCIOECONOMIC ANALYSIS OF PRODECER III EFFECTIVENESS IN PEDRO AFONSO, TOCANTINS STATE, BRAZIL

Directory of Open Access Journals (Sweden)

Alan Kardec Barbiero

2009-10-01

Full Text Available

O artigo se propõe a analisar os efeitos do Programa de Cooperação Nipobrasileira para o Desenvolvimento dos Cerrados (Prodecer, terceira fase, sobre indicadores de qualidade de vida do município de Pedro Afonso, Estado do Tocantins. Os resultados da pesquisa apontam que o Prodecer III trouxe, por um lado, grandes avanços na vida econômica da população de Pedro Afonso, mas contribuiu, também, para o aumento do quadro de pobreza urbana e exclusão social.

PALAVRAS-CHAVE: Impacto social; desenvolvimento sustentável; dimensão social; Prodecer.

This paper analyzes the impacts caused by the Nipo-Brazilian Cooperation Program for the Development of Cerrados (Prodecer, third phase, on quality of life of the municipality of Pedro Afonso, State of Tocantins

Factors Associated with the Time of Admission among Notified Dengue Fever Cases in Region VIII Philippines from 2008 to 2014.

Science.gov (United States)

Abello, Jason Echavez; Gil Cuesta, Julita; Cerro, Boyd Roderick; Guha-Sapir, Debarati

2016-10-01

In cases of Dengue fever, late hospital admission can lead to treatment delay and even death. In order to improve early disease notification and management, it is essential to investigate the factors affecting the time of admission of Dengue cases. This study determined the factors associated with the time of admission among notified Dengue cases. The study covered the period between 2008 and 2014 in Region VIII, Philippines. The factors assessed were age, sex, hospital sector, hospital level, disease severity based on the 1997 WHO Dengue classification, and period of admission (distinguishing between the 2010 Dengue epidemic and non-epidemic time). We analysed secondary data from the surveillance of notified Dengue cases. We calculated the association through chi-square test, ordinal logistic regression and linear regression at p value Dengue cases. The reported cases included a majority of children (70.09%), mild cases of the disease (64.00%), patients from the public sector (69.82%), and non-tertiary hospitals (62.76%). Only 1.40% of cases had a laboratory confirmation. The epidemic period in 2010 comprised 48.68% of all the admitted cases during this period. Late admission was more likely among adults than children (pDengue guidelines in order to standardize the admission criteria and time across hospitals.

STS-95 Mission Specialist Pedro Duque in white room

Science.gov (United States)

1998-01-01

In the environmental chamber known as the white room, STS-95 Mission Specialist Pedro Duque of Spain, with the European Space Agency, is prepared by white room crew members Danny Wyatt (left) and Travis Thompson (right) for entry into the Space Shuttle Discovery for his first flight into space. The STS-95 mission, targeted for launch at 2 p.m. EST on Oct. 29, is expected to last 8 days, 21 hours and 49 minutes, and return to KSC at 11:49 a.m. EST on Nov. 7.

The lower San Pedro River: hydrology and flow restoration for biodiversity conservation

Science.gov (United States)

Jeanmarie Haney

2005-01-01

The lower San Pedro River, downstream from Benson, is a nearly unfragmented habitat containing perennial flow reaches that support riparian vegetation that serve as “stepping stones” for migratory species. The Nature Conservancy has purchased farm properties and retired agricultural pumping along the lower river, based largely on results from hydrologic analyses...

Time Transfer Experiment by TCE on the ETS-VIII Satellite

National Research Council Canada - National Science Library

Nakagawa, Fumimaru; Takahashi, Yasuhiro; Amagai, Jun; Tabuchi, Ryo; Hama, Shin'ichi; Hosokawa, Mizuhiko

2007-01-01

.... At NICT, we developed Time Comparison Equipment (TCE) both onboard ETS-VIII and in the Earth station for precise time transfer between the atomic clocks on the satellite and a ground reference clock...

La encrucijada en Pedro Páramo de Juan Rulfo / The Crossroads in Pedro Páramo by Juan Rulfo

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Lilia Leticia García-Peña

2015-08-01

Full Text Available La obra de Juan Rulfo sintetiza la realidad del campo mexicano, captura el contorno de las identidades individuales y de la estructura de la interacción social del mundo que tanto le preocupó y del que es intérprete indiscutible, pero también supo convertir en materia narrativa aquellas atmósferas que rebasan el contexto mexicano y social. En este trabajo abordaré el tema de la encrucijada en el imaginario simbólico de Pedro Páramo (1955 como expresión de una reelaboración del mito de Hermes, analizaré cómo la novela de Juan Rulfo muestra estos ecos herméticos y qué sentido estético y sociocultural tiene esta resonancia mítica.

MONUMENTO A PEDRO PÉREZ RODRÍGUEZ [Material gráfico

OpenAIRE

Anonymous

1980-01-01

ANEXO SELLO DE LA COMISIÓN DEL PATRIMONIO HISTÓRICO ARTÍSTICO DE GÁLDAR. MONUMENTO LEVANTADO POR LA PARROQUIA DE SAN JOSÉ DE LOS CAIDEROS A SU PRIMER PÁRROCO, EL SACERDOTE MAJORERO, DON PEDRO PÉREZ RODRÍGUEZ. SE ENCUENTRA EL BUSTO EN LA GLORIETA LATERAL DEL CENTRO. Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2015

Acúmulo de massa seca e marcha de absorção de nutrientes em mudas de goiabeira 'Pedro Sato' Dry matter storage and absorption route of nutrients in guava seedlings "Pedro Sato"

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Leonardo Mariano Dias Augostinho

2008-01-01

Full Text Available Objetivou-se determinar a curva de acúmulo da matéria seca de mudas e a marcha de absorção de macro e micronutrientes de goiabeira cultivar 'Pedro Sato'. O delineamento experimental foi o inteiramente casualizado, com três repetições. Foram utilizadas sete coletas de plantas de goiabeira 'Pedro Sato', em cultivo hidropônico, em casa de vegetação da Unesp, Campus de Jaboticabal. Nas coletas, avaliaram-se o crescimento das plantas e o acúmulo de nutrientes, a cada 15 dias, durante 120 dias após o transplantio. As mudas de goiabeira proporcionaram maior acúmulo de biomassa no órgão folha em relação ao caule e à raiz. Observou-se alta absorção dos nutrientes, no período de 60 a 90 dias após o transplantio, nas mudas de goiabeira. O acúmulo de nutrientes das mudas de goiabeira (planta inteira foi de 340, 44, 380, 173, 33 e 40 mg planta-1, respectivamente para N, P, K, Ca, Mg, S, e de 743, 118, 5.114, 2.151, 566 mg planta-1, respectivamente, para B, Cu, Fe, Mn e Zn.This work aimed to determine the dry matter storage curve of seedlings and the absorptions of macro and micro nutrients of guava tree cultivar 'Pedro Sato'. It was used randomized design with three repetitions. Seven samples of guava plants cultivar 'Pedro Sato' were used in hydroponic growth in the greenhouse located at UNESP- Jaboticabal Campus, São Paulo State, Brazil. It was evaluated the samples of plants growing and the nutrients storage every 15 days, during 120 days after the transplanting. The seedlings of guava priorized the dry matter storage of leaves in relation of the stem and leaves. The guava seedlings presented high absorption of nutrients in the period of 60 and 90 days after the transplanting. The nutrients storage of the guava seedlings (whole plant were of : 340; 44; 380; 173; 33; and 40 mg plant-1, respectively, for N, P, K, Ca, Mg, S and 743; 118; 5114; 2151; 566µg plant-1, respectively for B, Cu, Fe, Mn, and Zn.

Mission Specialist Pedro Duque undergoes equipment check prior to launch

Science.gov (United States)

1998-01-01

In the Operations and Checkout Building, STS-95 Mission Specialist Pedro Duque of Spain, with the European Space Agency, gets help with his suit from suit technician Tommy McDonald. The STS-95 crew were conducting flight crew equipment fit checks prior to launch on Oct. 29. STS-95 is expected to launch at 2 p.m. EST on Oct. 29, last 8 days, 21 hours and 49 minutes, and land at 11:49 a.m. EST on Nov. 7.

Un documento desconocido de Pedro Fermín de Vargas

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Alberto Corradine Angulo

1967-11-01

Full Text Available Varios autores se han detenido a estudiar la vida singularísima de don Pedro Fermín de Vargas, quien bien podría llevar con sobrados méritos el título de Precursor; testimonio de este aserto son sus escritos y su vida misma, llenas de la profundidad de sus observaciones, que presentaba a las autoridades virreinales con gran sencillez y naturalidad, aún cuando pretendía ocultar el verdadero alcance de sus planteamientos

Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic ...

Indian Academy of Sciences (India)

furosemide by Ag(III) periodate complex in aqueous alkaline medium. SHWETA J .... Os(VIII) catalysed DPA oxidation, the order in [OH. −. ] ... Victoria-3170, Australia) connected to a rapid ..... follows. The furosemide, periodate and hydroxide ion.

Underground Test Area Subproject Phase I Data Analysis Task. Volume VIII - Risk Assessment Documentation Package

Energy Technology Data Exchange (ETDEWEB)

None

1996-12-01

Volume VIII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the risk assessment documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

The Reliability of Methodological Ratings for speechBITE Using the PEDro-P Scale

Science.gov (United States)

Murray, Elizabeth; Power, Emma; Togher, Leanne; McCabe, Patricia; Munro, Natalie; Smith, Katherine

2013-01-01

Background: speechBITE (http://www.speechbite.com) is an online database established in order to help speech and language therapists gain faster access to relevant research that can used in clinical decision-making. In addition to containing more than 3000 journal references, the database also provides methodological ratings on the PEDro-P (an…

A interação existencial entre seres humanos e animais no romance Pedro Páramo, de Juan Rulfo = The existential interaction between human beings and animals in the novel Pedro Páramo by Juan Rulfo

Directory of Open Access Journals (Sweden)

Evely Vânia Libanori

2013-01-01

Full Text Available Em Pedro Páramo, de Juan Rulfo, o corvo, o cavalo e o gato são animais que mantêm estreita ligação existencial com o ser humano. A interação ser humano-animal é fundamental para o entendimento de temas filosóficos presentes no romance, como a identidade humana, o outro, a morte. O corvo é o batedor da chegada de Juan Preciado no mundo da morte. O cavalo de Miguel Páramo é o único ser que sofre, verdadeiramente, a morte do seu tutor. O gato é o animal que faz visitas noturnas a Susana San Juan, com quem estabelece um diálogo somente inteligível para os dois. A integração entre personagens humanas e animais em Pedro Páramo mostra a comunicação entre seres pertencentes a diferentes espécies animais. No romance, seres humanos, corvos, cavalos e gatos têm mais semelhanças entre si do que a cultura ocidental antropocêntrica conhece.In Pedro Páramo by Juan Rulfo, the raven, the horse and the cat are animals that maintain a close existential link to the human beings. In the book, this human being/animal interaction is fundamental to the understanding of philosophical themes such as the identity, the other, and the death. In the story, the raven is the escort of Juan Preciado arrival into the death world. Miguel Páramos’s horse is the only being that genuinely suffers because of the death of its guardian, that is, Miguel’s death. The cat is the animal that make night visits to Susana San Juan to whom it speaks in a way that is understood by the two of them only. The connection between human and animal characters in Pedro Páramo shows the communication among beings that belong to different animal species. In the novel, human beings, ravens, horses, and cats are much more alike than the western anthropocentric culture has it.

The Funnel Geometry of Open Flux Tubes in the Low Solar Corona Constrained by O VI and Ne VIII Outflow

Science.gov (United States)

Byhring, Hanne S.; Esser, Ruth; Lie-Svendsen, Oystein

2008-01-01

Model calculations show that observed outflow velocities of order 7-10 km/s of C IV and O VI ions, and 15-20 km/s of Ne VIII ions, are not only consistent with models of the solar wind from coronas holes, but also place unique constraints on the degree of flow tube expansion as well as the location of the expansion in the transition region/lower corona.

Improvements mineral dressing and extraction processes of gold-silver ores from San Pedro Frio Mining District, Colombia

International Nuclear Information System (INIS)

Yanez Traslavina, J. J.; Vargas Avila, M. A.; Garcia Paez, I. H.; Pedraza Rosas, J. E.

2005-01-01

The San Pedro Frio district mining, Colombia, is a rich region production gold-silver ores. Nowadays, the extraction processes used are amalgamation, percolation cyanidation and precipitation with zinc wood. Due to the ignorance of the ore characteristics, gold and silver treatment processes are inadequate and not efficient. In addition the inappropriate use of mercury and cyanide cause environmental contamination. In this research the ore characterization was carried out obtained fundamental parameters for the technical selection of more efficient gold and silver extraction processes. Experimental work was addressed to the study of both processes the agitation cyanidation and the adsorption on activated carbon in pulp. As a final result proposed a flowsheet to improve the precious metals recovery and reduce the environment contamination. (Author)

PERSEPSI SISWA KELAS VIII TENTANG KESEHATAN REPRODUKSI REMAJA DAN PENYAKIT MENULAR SEKSUAL

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Omega Rianda Rustian

2015-06-01

This study is based on interviews conducted in one of the BK school teacher. This study aimed to determine the perception class VIII student perceptions on adolescent reproductive health and sexually transmitted diseases in SMP Islam Sultan Agung 1 Semarang. The method used in this research is descriptive quantitative survey methods. Population in this research is class VIII SMP Islam Sultan Agung 1 Semarang totaling 151 students with a sampling technique used is accidental to obtain a sample of 60. Data collection tools in the form of a psychological scale with data analysis techniques using descriptive analysis percentage. The average result of students' perceptions on adolescent reproductive health in the high category (74% and perceptions of students about sexually transmitted diseases in the very high category (76%. That class VIII SMP Islam Sultan Agung 1 Semarang already have an idea of the meaning of adolescent reproductive health is a state of good health both physically healthy, functioning, as well as reproductive performance in adolescent and the  meaning of sexually transmitted diseases are caused by viruses, parasites, or function as a result of sexual intercourse.

Pedro José Velarde: un rapsoda callejero en el México del siglo XVIII

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Bernabéu Albert, Salvador

2005-12-01

Full Text Available The Inquisition trial of Pedro José Velarde in 1768 reveals the life and works of this street poet that was very popular in the market of El Baratillo. Velarde was imprisoned because some of his compositions were dedicated to praise the activities of the jesuits, expelled in 1767. He was sentenced to three years in prison serving in the San Juan de Dios Hospital, but died in poverty in 1768.

Gracias al proceso abierto por la Inquisición mexicana en 1768 podemos reconstruir parcialmente la vida y la obra de Pedro José Velarde, poeta callejero que se hizo famoso en el mercado del Baratillo. Algunas de sus composiciones fueron dedicadas a ensalzar las actividades de los jesuitas, expulsados en 1767, por lo que fue encarcelado y sentenciado a servir durante tres años en el hospital de San Juan de Dios. Murió en 1784 en la pobreza.

Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation.

Science.gov (United States)

Witsenburg, C P J; Rosendaal, F R; Middeldorp, J M; Van der Meer, F J M; Scherjon, S A

2005-01-01

Recently, acquired as well as genetic prothrombotic factors are associated with thrombotic events. These factors have also been related to conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome and severe intrauterine growth restriction (IUGR). The aim of this study was to determine whether elevated factor VIII levels are associated with uteroplacental insufficiency, in particular pre-eclampsia, HELLP syndrome or pregnancy-induced hypertension and intrauterine growth retardation. Plasma samples of 75 women with a history of pregnancy complicated by pre-eclampsia, HELLP syndrome, pregnancy induced hypertension or intrauterine growth restriction were tested for factor VIII:C (FVIII:C) levels at a minimum of 10 weeks post-partum. Laboratory results were compared to factor VIII:C levels found in a healthy control group of 272 women. Mean factor VIII:C levels were similar at 123 IU/dl in both the patient group and the controls. In a logistic regression model, after adjusting for age and blood group, no effect of factor VIII:C levels on the risk of pregnancy complications was observed, with the exception of IUGR with (OR 2.9, CI 1.0-8.7) or without hypertension (OR 2.0, CI 0.7-6.4). If the elevated level of factor VIII would be the sole factor responsible for the increased risk observed, one would expect to find an effect of blood group on risk as well (blood group being an important determinant of FVIII:C). While no such effect could be shown a causal relationship between elevated levels of factor VIII and conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome, pregnancy-induced hypertension and IUGR is not very likely.

Class VIII Medical Materiel Controls in the U.S. European Command

National Research Council Canada - National Science Library

1991-01-01

.... Class VIII medical materiel inventories are maintained as part of the U.S. war reserve stocks to ensure military readiness and to provide needed health care during wartime or contingencies. The U.S...

Pedro Duque Cornejo y la escultura barroca en Sevilla: nuevas aportaciones

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Manuel García Luque

2013-01-01

Full Text Available Pedro Duque Cornejo (1678-1757 es una figura de capital importancia para comprender el desarrollo del barroco meridional durante la primera mitad del siglo XVIII. En este artículo damos a conocer una docena de nuevas atribuciones repartidas por Sevilla y provincia, que vienen a incrementar su ya de por sí nutrido catálogo y que avalan su carácter polifacético como escultor, pintor y arquitecto de retablos.

Construction of a mouse model of factor VIII deficiency by gene targeting

Energy Technology Data Exchange (ETDEWEB)

Bi, L.; Lawler, A.; Gearhart, J. [Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [and others

1994-09-01

To develop a small animal model of hemophilia A for gene therapy experiments, we set out to construct a mouse model for factor VIII deficiency by gene targeting. First, we screened a mouse liver cDNA library using a human FVIII cDNA probe. We cloned a 2.6 Kb partial mouse factor VIII cDNA which extends from 800 base pairs of the 3{prime} end of exon 14 to the 5{prime} end of exon 26. A mouse genomic library made from strain 129 was then screened to obtain genomic fragments covering the exons desired for homologous recombination. Two genomic clones were obtained, and one covering exon 15 through 22 was used for gene targeting. To make gene targeting constructs, a 5.8 Kb genomic DNA fragment covering exons 15 to 19 of the mouse FVIII gene was subcloned, and the neo expression cassette was inserted into exons 16 and 17 separately by different strategies. These two constructs were named MFVIIIC-16 and MFVIIIC-17. The constructs were linearized and transfected into strain 129 mouse ES cells by electroporation. Factor VIII gene-knockout ES cell lines were selected by G-418 and screened by genomic Southern blots. Eight exon 16 targeted cell lines and five exon 17 targeted cell lines were obtained. Three cell lines from each construct were injected into blastocysts and surgically transferred into foster mothers. Multiple chimeric mice with 70-90% hair color derived from the ES-cell genotype were seen with both constructs. Germ line transmission of the ES-cell genotype has been obtained for the MFVIIIC-16 construct, and multiple hemophilia A carrier females have been identified. Factor VIII-deficient males will be conceived soon.

RELATIONSHIP OF INTEREST, LEARNING MOTIVATION AND ATTITUDE WITH RESULTS LEARNING CLASS VIII SMP STATE 13 MAKASSAR

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Putri Athirah Azis

2016-12-01

Full Text Available The study aims at examining (1 the correlation of learning interest towards learning result of grade students, (2 the correlation of learning motivation towards learning result of grade students, (3 the correlation of students attitude towards learning result, (4 the correlationof interest, learning motivation, and attitude collaboratively towards learning result. The study is an ex post facto. The population of the study was grade VIII at SMPN 13 Makassar. Samples were 105 students taken by employing random sampling technique. Data were collected through questionnaire and documentation. Data were analyzed using regression test. The result of study reveal that (1 there is significant correlation (p<0,01 of interest towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,718 and its effectiveness contribution (R2 is 51,5%, (2 there is significant correlation (p<0,01 of motivation towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,775 and its effectiveness contribution (R2 is 60,1%, (3 there is significant correlation (p<0,01 of attitude towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,737 and its effectiveness contribution (R2 is 54,4%, (4 there is significant correlation (p<0,01 of interest, motivation and attitude collaboratively towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,861 and its effectiveness contribution (R2 is 74,1%,

Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

International Nuclear Information System (INIS)

Starkov, Konstantin E.

2011-01-01

In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

Energy Technology Data Exchange (ETDEWEB)

Starkov, Konstantin E., E-mail: konst@citedi.mx [CITEDI-IPN, Av. del Parque 1310, Mesa de Otay, Tijuana, BC (Mexico)

2011-08-22

In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

Pedro García y el color del vidrio

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María Teresa González Vicario

1999-01-01

Full Text Available El vidrio es uno de los materiales que ha alcanzado una dimensión escultórica en el siglo XX. Fue a mediados de este siglo, aproximadamente, cuando tuvo lugar su incorporación a la escultura contemporánea, y aunque España se ha sumado con un cierto retraso a esta nueva vertiente del lengueje escultórico, no son pocos los nombres de escultores que podrían ser citados por haber descubierto las posibilidades que el vidrio encierra como material escultórico. Uno de ellos es Pedro García, quien ha encontrado en el vidrio laminado, un material de procedencia industrial, su medio de expresión plástica. El análisis de su evolución artística hasta el momento actual constituye el objeto de este artículo, para lo cual se ha partido de unas primeras obras que obedecen a un planteamiento constructivo, racionalista, y en las que el vidrio ha sido trabajado en frío.The apparition of glass as a new material in sculpture dates from the middle of the XXth century. Spain has incorporated the sculptoric possibilities of glass later than other countries, but it has had an important following by an important group of sculptors. One of them is Pedro García, who has found in laminated glass, an industrial type of glass, his chief inspiration. This article traces the history of his artistic evolution. In the beginning his sculptures were very constructive and rational. Later, he developed a special technique working on glass in the process of formation through heat.

Institución Educativa Técnico Industrial Pedro Antonio Molina: eje de desarrollo y bienestar para la comunidad

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DANIEL ALBERTO ÁLVAREZ WATSON

2012-01-01

Full Text Available El caso analiza la situación particular de la Institución educativa Técnico Industrial Pedro Antonio Molina, el liderazgo del rector y el apoyo del sector privado en los procesos de gestión de la calidad. Esto motiva a los integrantes de la institución a trabajar en equipo para lograr la certificación de calidad, mejorando sus resultados académicos año tras año, destacándose a nivel regional y nacional, y generando cambios sociales en su entorno. Metodológicamente, se identificó una institución líder en la ciudad de Cali (Colombia, luego fuentes de información en el contexto local, regional y mundial, consolidándose un caso que muestra las mejores prácticas que una institución educativa realiza para lograr un modelo administrativo susceptible de ser replicado en otras instituciones.

Institución Educativa Técnico Industrial Pedro Antonio Molina: eje de desarrollo y bienestar para la comunidad

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Daniel Alberto Álvarez Watson, Mg

2012-04-01

Full Text Available El caso analiza la situación particular de la Institución educativa Técnico Industrial Pedro Antonio Molina, el liderazgo del rector y el apoyo del sector privado en los procesos de gestión de la calidad. Esto motiva a los integrantes de la institución a trabajar en equipo para lograr la certificación de calidad, mejorando sus resultados académicos año tras año, destacándose a nivel regional y nacional, y generando cambios sociales en su entorno. Metodológicamente, se identificó una institución líder en la ciudad de Cali (Colombia, luego fuentes de información en el contexto local, regional y mundial, consolidándose un caso que muestra las mejores prácticas que una institución educativa realiza para lograr un modelo administrativo susceptible de ser replicado en otras instituciones.

Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII.

Science.gov (United States)

El Adib, Ahmed Ghassan; Majdi, Farah; Dilai, Mohamed Othmane; Asmouki, Hamid; Bassir, Ahlam; Harou, Karam; Soumani, Abderraouf; Younous, Said; Mahmal, Lahoucine

2014-01-01

Inherited combined factor V and factor VIII deficiency (F5F8D) is autosomal recessive transmission disorder. Epistaxis, postsurgical bleeding, and menorrhagia are the most common symptoms. The risk of miscarriage and placental abruption is consequent. We report a case of successful pregnancy in a patient with F5F8D. 20-year-old woman, born of consanguineous parents, third gestate, first parity, two miscarriages, admitted for child birth of a spontaneous pregnancy estimated at 38 weeks and was diagnosed with F5F8D. At admission, patient was hemodynamically stable, with good obstetric conditions. The biologic results showed low levels of PT (52%), factor V (7%), and factor VIII (5%), and the activated partial thromboplastin time was prolonged (68,6%). Parturient was admitted in intensive care unit, maternal and fetal monitoring was performed. Fresh frozen plasma (FFP) and factor VIII concentrates were perfused at the induction of labor. Analgesia used fentanyl titration. The delivery gave birth to a newborn male, with Apgar 10/10 and 3000 g. The puerperium was simple without any important bleeding. Laboratory tests for the newborn were acceptable. Little literature is available on this subject and there are no guidelines available concerning pregnancy; we chose to prescribe a combination of factor VIII concentrate and FFP in pre-, per- and postpartum. The same protocol was successfully used in a patient before dental extraction and prostatectomy. Vaginal delivery is possible, as our case. Management by multidisciplinary team is recommended.

A close insight to factor VIII inhibitor in the congenital hemophilia A.

Science.gov (United States)

Tabriznia-Tabrizi, Shamsoreza; Gholampour, Marzie; Mansouritorghabeh, Hassan

2016-09-01

Hemophilia A (HA) has an X-linked pattern of inheritance and is the most common of the hemorrhagic disorders. HA is caused by a decreased or deficiency of the functional clotting factor VIII (FVIII) and effects 1 in 5000-10,000 male births. The common treatment for hemophilia is replacement therapy by plasma-derived or recombinant FVIII. Approximately 20-30% of people with a severe type of HA develop an inhibitor and this phenomenon is the main challenge in the management of these patients. Genetic factors and environmental determinants contribute to inhibitor development. Here, the roles of various genetic and environmental factors such as the type of FVIII concentrate used, the number of exposure days, and peak treatment time will be discussed in detail. It seems this information is helpful for hematologists. A literature review was done in January 2016 on PubMed and Scopus using the following keywords:' h(a)emophilia A & factor VIII inhibitor', 'h(a)emophilia A & factor VIII alloantibody', 'h(a)emophilia A & inhibitor'. There was no time limitation; however, there was an English language limitation placed on the articles selected. Expert commentary: Influential genetic and environmental factors in developing inhibitors have been discussed. Most of the risk factors are related to previously untreated patients with hemophili.

Carnaval de Sodoma de Pedro Antonio Valdez: retratos y vestiduras travestis

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Julio Penenrey Navarro

2014-12-01

Full Text Available El travestimiento y las identidades queer son temas obviados y desentendidos por la crítica literaria que la novela Carnaval de Sodoma (2002, del escritor dominicano Pedro Antonio Valdez, ha merecido hasta el momento. A través del surgimiento de tres personajes travestidos de la obra —Tora, el Barón del cementerio-La Fortunata y Changsán- Princesa de Jade— examinaremos cómo la acción travesti desestabiliza el imaginario de naturalización y de complementariedad que el discurso normativo ha asignado a los géneros tradicionales (masculino/femenino, y repensaremos nociones como género y sexualidad, comúnmente establecidas por el pensamiento heterocentrado como entidades fijas e inmutables. Cross-dressing and queer identities constitute themes that are ignored and neglected by the literary critic that the novel Carnaval de Sodoma (2002, by Dominican writer Pedro Antonio Valdez has had until now. We will analyze three transvestite characters —Tora, the Baron of the graveyard-La Fortunata and Changsán-Princess of Jade— and examine how the transvestite action destabilize the naturalization and complementarization imaginary that the normative discourse has assigned to the traditional genders (masculine/femenine. We will rethink notions such as gender and sexuality, usually established by the heterocentered thought as fixe and immutable entities.

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A

Science.gov (United States)

Mahlangu, Johnny; Kuliczkowski, Kazimierz; Karim, Faraizah Abdul; Stasyshyn, Oleksandra; Kosinova, Marina V.; Lepatan, Lynda Mae; Skotnicki, Aleksander; Boggio, Lisa N.; Klamroth, Robert; Oldenburg, Johannes; Hellmann, Andrzej; Santagostino, Elena; Baker, Ross I.; Fischer, Kathelijn; Gill, Joan C.; P’Ng, Stephanie; Chowdary, Pratima; Escobar, Miguel A.; Khayat, Claudia Djambas; Rusen, Luminita; Bensen-Kennedy, Debra; Blackman, Nicole; Limsakun, Tharin; Veldman, Alex; St. Ledger, Katie

2016-01-01

Recombinant VIII (rVIII)-SingleChain is a novel B-domain–truncated recombinant factor VIII (rFVIII), comprised of covalently bonded factor VIII (FVIII) heavy and light chains. It was designed to have a higher binding affinity for von Willebrand factor (VWF). This phase 1/3 study investigated the efficacy and safety of rVIII-SingleChain in the treatment of bleeding episodes, routine prophylaxis, and surgical prophylaxis. Participants were ≥12 years of age, with severe hemophilia A (endogenous FVIII <1%). The participants were allocated by the investigator to receive rVIII-SingleChain in either an on-demand or prophylaxis regimen. Of the 175 patients meeting study eligibility criteria, 173 were treated with rVIII-SingleChain, prophylactically (N = 146) or on-demand (N = 27). The total cumulative exposure was 14 306 exposure days (EDs), with 120 participants reaching ≥50 EDs and 52 participants having ≥100 EDs. Hemostatic efficacy was rated by the investigator as excellent or good in 93.8% of the 835 bleeds treated and assessed. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.0, 2.4) and the median overall annualized bleeding rate (ABR) was 1.14 (Q1, Q3: 0.0, 4.2). Surgical hemostasis was rated as excellent/good in 100% of major surgeries by the investigator. No participant developed FVIII inhibitors. In conclusion, rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy in surgery and in the control of bleeding events, low ABR in patients on prophylaxis, and a favorable safety profile in this large clinical study. This trial was registered at www.clinicaltrials.gov as #NCT01486927. PMID:27330001

La ex–residencia del Presidente Pedro Montt Montt en la comuna de Independencia: condición patrimonial, estado actual y argumentos para su conservación / The former residence of President Pedro Montt Montt in the town of Independence: asset condition, status and conservation arguments.

Directory of Open Access Journals (Sweden)

Sahady Villanueva, Antonio

2006-11-01

Full Text Available Los autores plantean un análisis FODA que busca valorizar la residencia de Pedro Montt, Presidente de Chile entre 1906 y 1910. La vivienda ha sobrevivido más de 100 años dando lugar a distintos programas y usuarios, pero ahora su mantenimiento requiere de una acción coordinada./The authors through a "FODA" type analysis demonstrate the patrimonial value of Pedro Montt's residency (president of chile from 1906 to 1910. The house has survived for over 100 years the change of use and dwellers, but now its maintenance requires a coordinated action.

Ética, cinema e documentário - Poéticas de Pedro Costa

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Carlos Melo Ferreira

2009-12-01

Full Text Available There is no specific documentary ethics but ethics film covers it, without ignoring the rules of conduct recommended in the documentary. In the films of Pedro Costa the border is crossed between documentary and fiction, especially in its central diptych, according to an ethics and the technology determines its aesthetics. Making movies is ethical and political.

Acerca del rol de Pedro Bermúdez en el Cantar de Mio Cid: Un acercamiento a su figura épica

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Érica Janín

2007-11-01

Full Text Available This work makes an attempt on getting close to the literary figure of Pedro Bermúdez in the Cantar de Mio Cid that allows it to characterize him as a peculiar hero; and proposes that Pedro represents a type of hero which is different to the model the Cantar means to coin, perhaps more primitive and alternative to the cidian paradigm, thus the virtues and values of the tradition of the most arcaic epic songs are not eliminated but displaced to a hero that seconds the protagonist, complementing him at the same time.

The Upper San Pedro Partnership: A Case Study of Successful Strategies to Connect Science to Societal Needs

Science.gov (United States)

Goodrich, D. C.; Richter, H.; Varady, R.; Browning-Aiken, A.; Shuttleworth, J.

2006-12-01

The Upper San Pedro Partnership (USPP) (http://www.usppartnership.com/) has been in existence since 1998. Its purpose is to coordinate and cooperate in the implementation of comprehensive policies and projects to meet the long-term water needs of residents within the U.S. side of the basin and of the San Pedro Riparian National Conservation Area. The Partnership consists of 21 local, state, and Federal agencies, NGO's and a private water company. In 2004 it was recognized by Congress in Section 321 of Public Law 108-136 and required to make annual reports to Congress on its progress in bringing the basin water budget into balance by 2011. The Partnership is dedicated to science-based decision making. This presentation will provide an overview of the evolution of natural resources research in the binational (U.S.-Mexico) San Pedro Basin into a mature example of integrated science and decision making embodied in the USPP. It will discuss the transition through science and research for understanding; to science for addressing a need; to integrated policy development and science. At each stage the research conducted becomes more interdisciplinary, first across abiotic disciplines (hydrology, remote sensing, atmospheric science), then a merging of abiotic and biotic disciplines (adding ecology and plant physiology), and finally a further merging with the social sciences and policy and decision making for resource management. Federal, university, and NSF SAHRA Science and Technology Center research has been planned and conducted directly with the USPP. Because of the success the San Pedro has been designated as an operational HELP (Hydrology for the Environment, Life, and Policy) demonstration basin—the most advanced category. Lessons learned from this experience will be reviewed with the intent providing guidance to ensure that hydrologic and watershed research is socially and scientifically relevant and will directly address the needs of policy makers and resource

D. Pedro II tradutor: análise do processo criativo

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Sergio Romanelli

2012-10-01

Full Text Available http://dx.doi.org/10.5007/2175-7968.2012v2n30p101   Nesta comunicação investiga-se o trabalho tradutório de D. Pedro II. Ao longo de sua vida demonstrou grande interesse pelas línguas. Falava alemão, italiano, espanhol, francês, latim, hebraico e tupi-guarani. Lia grego, árabe, sânscrito e provençal. Fez traduções do grego, do hebraico, do árabe, do francês, do alemão, do italiano e do inglês. Objetiva-se delinear o processo criativo do tradutor através da Crítica Genética e dos Estudos Descritivos da Tradução, pois ambos privilegiam o processo em relação ao produto final. As principais fontes documentais em que se baseiam as investigações aqui propostas são manuscritos autógrafos de traduções diretas do árabe, italiano, espanhol, francês e sânscrito, o diário do imperador, além de cartas e livros da sua biblioteca pessoal. Pretende-se reconstruir não somente o perfil de tradutor de D. Pedro II, suas ideias e atitudes acerca da atividade tradutória, mas também o estudo daquela rede única de contatos, leituras e influências procedentes de várias culturas, não somente europeias, que o imperador conseguiu tecer.

Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

Energy Technology Data Exchange (ETDEWEB)

Urgessa, Z.N., E-mail: zelalem.urgessa@nmmu.ac.za [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa); Oluwafemi, O.S. [Department of Chemistry and Chemical Technology, Walter Sisulu University, Mthatha Campus, Private Bag XI, 5117 (South Africa); Botha, J.R. [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa)

2012-05-15

In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH{sup -} to Zn{sup 2+} ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H{sup +} and OH{sup -} in the solution.

Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

International Nuclear Information System (INIS)

Urgessa, Z.N.; Oluwafemi, O.S.; Botha, J.R.

2012-01-01

In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH − to Zn 2+ ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H + and OH − in the solution.

PENGEMBANGAN KARAKTER KEDISIPLINAN DAN KEMAMPUAN PEMECAHAN MASALAH MELALUI MODEL LAPS-HEURISTIK MATERI LINGKARAN KELAS-VIII

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Sri Wahyuni

2015-08-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mengembangkan karakter kedisiplinan peserta didik, (2 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat meningkatkan kemampuan pemecahan masalah peserta didik, (3 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mencapai kriteria ketuntasan minimal yang ditentukan. Desain penelitian ini adalah kualitatif deskriptif, artinya menggambarkan atau mendeskripsikan kejadian-kejadian yang menjadi pusat perhatian secara kualitatif dan berdasar data kualitatif. Penentuan sumber data dalam penelitian ini menggunakan teknik purposive sampling, yaitu dipilih dengan pertimbangan dan tujuan tertentu. Data diperoleh dengan observasi, wawancara, dan tes yang kemudian dianalisis menggunakan analisis kualitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter kedisiplinan dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran LAPS-Heuristik.

Chromosome VIII disomy influences the nonsense suppression efficiency and transition metal tolerance of the yeast Saccharomyces cerevisiae.

Science.gov (United States)

Zadorsky, S P; Sopova, Y V; Andreichuk, D Y; Startsev, V A; Medvedeva, V P; Inge-Vechtomov, S G

2015-06-01

The SUP35 gene of the yeast Saccharomyces cerevisiae encodes the translation termination factor eRF3. Mutations in this gene lead to the suppression of nonsense mutations and a number of other pleiotropic phenotypes, one of which is impaired chromosome segregation during cell division. Similar effects result from replacing the S. cerevisiae SUP35 gene with its orthologues. A number of genetic and epigenetic changes that occur in the sup35 background result in partial compensation for this suppressor effect. In this study we showed that in S. cerevisiae strains in which the SUP35 orthologue from the yeast Pichia methanolica replaces the S. cerevisiae SUP35 gene, chromosome VIII disomy results in decreased efficiency of nonsense suppression. This antisuppressor effect is not associated with decreased stop codon read-through. We identified SBP1, a gene that localizes to chromosome VIII, as a dosage-dependent antisuppressor that strongly contributes to the overall antisuppressor effect of chromosome VIII disomy. Disomy of chromosome VIII also leads to a change in the yeast strains' tolerance of a number of transition metal salts. Copyright © 2015 John Wiley & Sons, Ltd.

The reflective look of Pedro Meyer: photography as the photography mediation problematic O olhar reflexivo de Pedro Meyer: a fotografia como problematizadora da própria mediação fotográfica

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Ana Carolina Lima Santos

2011-08-01

Full Text Available This paper discusses Pedro Meyer’s photographs with special attention to the way that they are arranged as a kind of reflection about the language of photography and its capacity of mediation. In that, the pictures made by Meyer seem to have a symbolic dimension, which request a conscious activity of the spectator – contradicting the idea of image as a form of alienation proposed by Guy Debord. O presente artigo propõe uma discussão acerca do trabalho do fotógrafo Pedro Meyer a partir do entendimento de que suas imagens, ao explicitar e esgarçar limites de noções caras à natureza do fotográfico, funcionam como reflexão sobre a linguagem fotográfica e o seu poder de mediação. Discute-se, assim, como as imagens de Meyer assumem uma dimensão simbólica que solicitam do espectador uma prática de ativa – opondo-se à noção debordiana de imagens alienantes.

“El olor nos lleva”: identidades ecológicas como un proceso de reconocimiento social y cultural de los “recuperadores” en el Relleno Sanitario Regional de Presidente, municipio de San Pedro, departamento del Valle.

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Walter Julián Quinchoa.

2011-01-01

Full Text Available By means of environmental anthropology and ethnography, this article describes the formation of the institutionalized ecological identity of the “recuperaters” in Presidente Regional Landfill in San Pedro, Valle Department. It shows how environmental discourses, by ascribing identities to people who work in the landfill, obscure their roles. “Recuperators,” by contrast, openly discuss and think about the importance of their job. They have been forging an identity of resistance, or a political identity, through the social memory of enduring regressive policies, such as law 1259 of 2008, legally permitted by Colombia’s 1991 constitution. In this way, they propose alternatives, such as their social organization, to “struggle” for their right to recycle in the face of a growing interest by domestic and multinational companies in turning “garbage” into a business.

33 CFR 165.1151 - Security Zones; liquefied hazardous gas tank vessels, San Pedro Bay, California.

Science.gov (United States)

2010-07-01

... a tank vessel as liquefied petroleum gas, liquefied natural gas, or similar liquefied gas products... Eleventh Coast Guard District § 165.1151 Security Zones; liquefied hazardous gas tank vessels, San Pedro... the sea floor, within a 500 yard radius around any liquefied hazardous gas (LHG) tank vessel that is...

Los proyectos intercomunales y de escala local: el caso de Pedro de Valdivia Norte, ex polígono “La Contadora” junto al río Mapocho (1928-1978./ Intercommunal projects and local scale: the case of Pedro de Valdivia Norte, former polygon

Directory of Open Access Journals (Sweden)

Pávez Reyes, M. Isabel

2009-06-01

Full Text Available Revisando brevemente las principales proposiciones en proyectos intercomunales de Santiago para el barrio de Pedro de Valdivia Norte 1928-1978, y, además, un megaproyecto de campo deportivo en ese polígono, en los años 1940s, se observa el carácter de discontinuidad y ruptura, que suele estar presente en el modo de hacer la ciudad./Reviewing briefly the main proposals of inter-project for the Santiago neighborhood of Pedro de Valdivia Norte 1928-1978, and also a giant in the sports field site, in the 1940s, there was the nature of discontinuity and rupture, which often a factor in the way of making the city.

Progress toward inducing immunologic tolerance to factor VIII

OpenAIRE

Scott, David W.; Pratt, Kathleen P.; Miao, Carol H.

2013-01-01

A major problem in treating hemophilia A patients with therapeutic factor VIII (FVIII) is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies. These antibodies block (inhibit) the procoagulant function of FVIII and thus are termed “inhibitors.” The currently accepted clinical method to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol requiring intensive FVIII treatment until inhibitor titers drop. Although often successful, ITI is ext...

Soil erosion and sedimentation rates in a small eutrophic lake in southern Chile estimated by 210Pb isotope analysis

International Nuclear Information System (INIS)

Cisternas, M.; Urrutia, R.; Araneda, A.; Debels, P.; Rios, F.

1999-01-01

The purpose of this research is to study the effects of historical land use patterns on soil erosion within the San Pedro Lake watershed (Concepcion, VIII Region, Chile). To this end, a geochronological reconstruction of the last 50 years was accomplished by 210 Pb isotope and photo-interpretation analysis through the use of GIS. The erosion rate has varied from 0.40 t ha -1 y -1 in 1955 to 0.86 t ha -1 y -1 in 1994. The decrease in native forest was closely coupled with the increase in exotic forestry. The Total Change, meaning the land use change without considering each typology, shows a constant trend indicating a greater degree of anthropogenic intervention. As opposed to the expected, there is no relationship between land use typologies and erosion rates, however it is possible to recognise some degree of dependency between Total Change and erosion values. It is concluded that over the last 50 years the soil erosion processes in the San Pedro Lake watershed may have been more regulated more by land use changes than by land use typologies themselves. (author)

Analyzing job entry examinations for Mathematics teachers of Colegio Pedro II during the 19th Century Analisando provas de concursos para professores de Matemática no Colégio Pedro II no século XIX

Directory of Open Access Journals (Sweden)

Flávia Soares

2010-06-01

Full Text Available In a attempt to investigate historic aspects of mathematics teaching, we ask what kind of instruments can be used to rebuild the professional trajectory of teachers and their practices, and what elements can be used to analyze the issues related to promotion of mathematics teacher in Brazil. One of these elements is public teacher job entry examinations. The analysis of these exams can show what were the requirements to work as a teacher and to clear other important questions about the conception about teachers at that time, about the contents they should teach, and others. This paper emphasizes the contents of the exams, and the formal requirements and abilities measured in those exams to act as a mathematics teacher in an important secondary education institution in the 19th Century, Colégio Pedro II. Keywords: Public contest. Mathematics teachers. Century XIX. Colégio Pedro II.Na tentativa de investigar aspectos históricos do ensino de Matemática, questionam-se que tipos de instrumentos podem ser utilizados para reconstruir a trajetória profissional do professor e de suas práticas e a partir de quais elementos pode-se examinar de maneira mais rigorosa as questões relativas ao acesso à profissão de professor de Matemática no Brasil. Um desses elementos são as provas de concursos. A análise dessas provas é capaz de revelar quais as exigências para o exercício do magistério e trazer à tona questões importantes a respeito da concepção da época em relação ao papel do professor, aos conteúdos que deveria ensinar, entre outros aspectos. Este trabalho enfatiza o conteúdo das provas, as exigências formais e as habilidades medidas nos exames para os cargos de professor de Matemática da principal instituição de ensino secundário do Brasil no século XIX, o Colégio Pedro II. Palavras-chave: Concursos. Professor de Matemática. Século XIX. Colégio Pedro II.

Leishmaniose tegumentar americana: flebotomíneos de área de transmissão, no município de Pedro de Toledo, região sul do Estado de São Paulo, Brasil American tegumentary leishmaniasis: phlebotominae of transmission area in the Pedro de Toledo County, in the South region of São Paulo State, Brazil

Directory of Open Access Journals (Sweden)

Maria de Fátima Domingos

1998-10-01

Full Text Available Considerado como área endêmica de leishmaniose tegumentar americana (LTA, o Vale do Ribeira, na região sul do Estado de São Paulo, teve 929 casos notificados nos últimos 15 anos. Com o objetivo de identificar a fauna flebotomínea, foram realizadas capturas quinzenais em área rural do município de Pedro de Toledo, durante um ano, a partir de maio de 1994. Foram utilizadas armadilhas de Shannon no peridomicílio e armadilhas luminosas, tipo CDC, nos ambientes: domiciliar (intra e peri e florestal (margem e interior, instaladas a partir do crepúsculo vespertino. Foram coletadas 8 espécies de flebotomíneos, totalizando 11.096 exemplares, sendo Lutzomyia intermedia a espécie dominante (96,4%. Esta espécie mostrou-se mais freqüente na primeira metade da noite, ocorrendo o ano inteiro, preferencialmente no ambiente domiciliar, o que indica sua preferência por ambiente antrópico. Os dados do presente trabalho ratificam L. intermedia como importante espécie vetora de LTA no Vale do Ribeira.Considered as an American tegumentary leishmaniasis (ATL endemic area, Ribeira Valley, in the south region of São Paulo State, presented 929 notified cases in the last 15 years. Aiming to identify the phlebotomine fauna, captures were performed fortnightly in the rural area of Pedro de Toledo County during one year, from may 1994 onwards. Set at dusk Shannon traps were used in the peridomicile and CDC light traps both intra and peridomiciliarly and at the edge and in the forest. Eight species summing to 11096 specimens were caught, L. intermedia being the dominant one (96,4%. More frequent all over the year during the first half of the night preferably in the domicile surroundings this species clearly indicated its preference for the anthropic environment. The data presented in this paper ratify L. intermedia as an important ATL vector species in the Ribeira Valley.

Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease

International Nuclear Information System (INIS)

Girma, J.P.; Ardaillou, N.; Meyer, D.; Lavergne, J.M.; Larrieu, M.J.

1979-01-01

Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125 I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (lgG) and their monovalent (Fab fragment) forms. Dose-response curves obtained by reacting a constant amount of antibody with serial dilutions of plasmas from normal or homozygous vWd demonstrated the specificity of the test. The accuracy was significantly higher with 125 I-Fab fragments of goat anti-F.VIII/WF antiserum than intact goat lgG or rabbit lgG or Fab fragments. The significant decrease of the slope of the dose-response curves obtained with plasma from variants of vWd has been interpreted as due to the presence of abnormal F.VIII/WF molecules with decreased antigenic reactivity. A similar anomaly was found in cryosupernatant prepared from normal plasma, paralleling similarities demonstrated between variants of vWd and cryosupernatant. Results of experiments performed by reacting constant plasma dilutions from control or variants of vWd and varying concentrations of anti-F.VIII/WF Fab fragments (rabbit or goat) confirmed the decreased antigenic reactivity of variant F.VIII/WF

Glioneuronal Heterotopia Presenting As a Cerebellopontine angle Tumor of the cranial Nerve VIII, Case Report.

Science.gov (United States)

Peris-Celda, M; Giannini, C; Diehn, F E; Eckel, L J; Neff, B A; Van Gompel, J J

2018-04-03

Vestibular schwannomas and meningiomas account for the great majority of lesions arising in the cerebellopontine angle (CPA). In this report, we present a case of glioneuronal heterotopia, also known as glioneuronal hamartoma, arising from the VIII cranial nerve, which is an extremely uncommon lesion. Important radiologic and surgical aspects are reviewed, which may help in early recognition and intraoperative decision making when these lesions are encountered. A healthy 29-year-old female presented with intermittent right facial numbness. Magnetic resonance imaging (MRI) showed an incidental minimally enhancing cerebellopontine angle lesion on the right VII-VIII cranial nerve complex. The patient declined serial observation and opted for operative intervention for resection. Intraoperatively, the lesion resembled neural tissue and was continuous with the VIII cranial nerve. Pathological analysis demonstrated mature glioneuronal tissue consistent with hamartomatous brain tissue. The patient maintained normal hearing and facial nerve function after surgery. Radiologic, surgical and pathological characteristics are described. Ectopic glioneuronal tissue of the VIII cranial nerve is a rare non-neoplastic lesion, and should be considered in the differential diagnosis of unusual appearing intracanalicular and cerebellopontine angle lesions. The congenital and benign nature of this entity makes observation a valid option for these cases, although they are so infrequent that they are often presumptively managed as vestibular schwannomas. Attempts to radically resect these lesions may result in higher rates of hearing loss or facial palsy due to their continuity with the cranial nerves. Copyright © 2018 Elsevier Inc. All rights reserved.

Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A.

Science.gov (United States)

Arai, M; Higuchi, M; Antonarakis, S E; Kazazian, H H; Phillips, J A; Janco, R L; Hoyer, L W

1990-01-15

The molecular defect responsible for moderate and severe hemophilia A has been identified for two unrelated patients with the CRM-positive form of this disorder (factor VIII activity of 0.02 and 0.05 U/mL with factor VIII antigen of 0.87 and 2.20 U/mL). In both cases, the immunopurified dysfunctional factor VIII protein is abnormal, in that the 80 Kd light chain is not cleaved by thrombin at arginine-1689. The basis for this failure was identified by polymerase chain reaction amplification of exon 14 of the variant factor VIII genes and direct sequencing of the amplified products. In both cases, a single base substitution (C to T) was identified that produces an arginine to cysteine substitution at amino acid residue 1689. These data identify the molecular defects of the two identical factor VIII variant proteins. The dysfunctional factor VIII has been designated "Factor VIII-East Hartford," the residence of the patient in whom the defect was first identified.

Lacerations to Zones VIII and IX: It Is Not Just a Tendon Injury

Directory of Open Access Journals (Sweden)

Charla R. Fischer

2011-01-01

Full Text Available Extensor tendon injuries are widely believed to be straightforward problems that are relatively simple to manage. However, these injuries can be complex and demand a thorough understanding of anatomy to achieve the best functional outcomes. When lacerations occur in the forearm as in Zones VIII and IX injury, the repair of the extensor tendon and muscle, and posterior interosseous nerve (PIN is often challenging. A review of the literature shows little guidance and attention for these injuries. We present four patients with injuries to Zones VIII and IX as well as a review of surgical technique, postoperative rehabilitation, and pearls that may be of benefit to those managing these injuries.

In Possession of a Stolen Weapon: From John Gay’s Macheath to Rubén Blades’ Pedro Navaja

Directory of Open Access Journals (Sweden)

Antonio Viselli

2012-05-01

Full Text Available This article analyses the cult salsa song “Pedro Navaja” by Panamanian artist Rubén Blades and the relevance of narrating such a genre peculiar to dancing, an re-writing of “Mack the Knife” – or Die Moritat von Mackie Messer – one which contains, as a sort of mise-en-abyme, elements not only of Kurt Weill’s song, but of both John Gay’s The Beggar’s Opera and Bertolt Brecht’s The Threepenny Opera. This study focuses on the fertile adaptation history of the highwayman Macheath since Gay’s work, on close-readings of “Pedro Navaja” – a narrativized cerebral salsa song – and on the ethics of adapting a character, story or genre. Finally, when the character Pedro Navaja is adapted from Blades’ song by a cineaste and playwright, Blades, furious with what others have done with ‘his’ character, decides to resuscitate his eponymous hero killed off at the end of the original song in order to regain the authority of his creation. From theoretical questions including how to read an adaptation or what constitutes an adaptation, this article focuses on the diachronic recurrences of a specific character-type, on the significance of juxtaposing particular historical junctures and on the violence of adaptation and authorship.

PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

OpenAIRE

Apri Dwi Astuti

2012-01-01

Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah ...

Construcción macrotextual y cancionero amoroso (Un acercamiento analítico a "La voz a ti debida" de Pedro Salinas)

OpenAIRE

Corencia Cruz, Joaquín

2008-01-01

La tesis Construcción macrotextual y cancionero amoroso. Unacercamiento analítico a La voz a ti debida de Pedro Salinas. Fue leídapor Joaquín Corencia Cruz en la Sala de Juntas de la Facultad deFilología de la Universidad de Valencia (España) el 7 de noviembre de2008.El trabajo investigador se desarrolla a lo largo de nuevecapítulos. En el primero se produce una introducción a la tesisrevisando desde la trayectoria vital y profesional de Pedro Salinas acómo el macrotexto poético de La voz se ...

Estudo citofotométrico da expressão do marcador tumoral Fator VIII e fatores prognósticos no adenocarcinoma gástrico Cytophotometric study of the expression of the tumoral marker Factor VIII and prognostic factors in gastrci adenocarcinoma

Directory of Open Access Journals (Sweden)

Mary Tossa Nakamura

2007-12-01

Full Text Available RACIONAL: No câncer gástrico, a incidência, o diagnóstico e as opções terapêuticas apresentaram melhorias nas últimas décadas, porém o prognóstico permanece reservado, especialmente devido à maioria dos pacientes procurarem recurso médico com tumores avançados, metastáticos ou cirurgicamente irressecáveis já no diagnóstico. Biologia molecular é área de conhecimento recente com grandes questionamentos a serem respondidos e a atualidade dos fatos científicos mostra que o caminho deverá ser através da identificação de marcadores tumorais. Os grandes avanços na área da informática aprimoraram a análise da imagem celular através da citofotometria de imagem que possibilita através da imunoistoquímica estudar a proliferação celular e a angiogênese que participa em diversos processos tumorais, sendo pesquisadas por vários marcadores. Atualmente estudos são realizados para demonstrar o valor prognóstico de suas expressões, contudo, no adenocarcinoma gástrico resultados têm sido divergentes e estudos escassos. OBJETIVOS: Identificar e quantificar citofotometricamente a expressão dos marcadores da angiogênese através do fator VIII no adenocarcinoma e comparar suas expressões com fa classificação de Bormann, profundidade de invasão tumoral, grau de diferenciação, envolvimento nodal, padrão histológico e idade. MÉTODOS: Foram estudados 21 pacientes com adenocarcinoma gástrico, identificados de 1998 a 2006. Para a detecção do Fator VIII foi realizada imunoistoquímica, com anticorpo policlonal para Fator VIII. Foi realizada análise citofotométrica informatizada pelo sistema SAMBA 4000. RESULTADOS: Dos 21 pacientes 61,90% eram do sexo masculino e 38,10% do feminino, com idade mediana de 65 anos e apenas um não marcou para o Fator VIII (95,24% de marcação. As médias dos índices de marcagem para o Fator VIII foram de 61,14% (desvio-padrão de 15,06, variando de 29,16 a 73,91. Tumores com classifica

Factor VIII and von Willebrand factor co-delivery by endothelial cells

NARCIS (Netherlands)

Bouwens, E.A.M.|info:eu-repo/dai/nl/314061894

2011-01-01

A defect in coagulation factor VIII (FVIII) results in the inherited bleeding disorder hemophilia A. Current treatment of hemophilia A is hampered by the need of frequent administration of costly FVIII products. Therefore gene therapy is an attractive alternative for protein replacement to treat

DE PAULO LEMINSKI A PEDRO ANTÔNIO GABRIEL: DIÁLOGOS ATEMPORAIS NA LITERATURA BRASILEIRA CONTEMPORÂNEA

Directory of Open Access Journals (Sweden)

Jennifer da Silva Gramiani Celeste (CES/JF

2017-05-01

Full Text Available

O presente artigo objetiva estabelecer diálogo entre poemas da autoria de Paulo Leminski e Pedro Antônio Gabriel. Os estudos relativos à Cibercultura, à Literatura e à Modernidade serão os norteadores deste trabalho. A realização deste estudo é justificada com base na relevância em compreender os diálogos contemplados pela Literatura Brasileira Contemporânea; ademais, a dinâmica que demarca a atual produção poética no Brasil, influenciada pelo advento da internet. É possível afirmar que os autores dialogam entre si, seja via jogos de natureza sonora ou visual, seja via temáticas contempladas. As conversas são atemporais, pois transcendem crenças e perspectivas inerentes a uma dada época.

Palavras-chave: Poesia. Literatura Brasileira Contemporânea. Paulo Leminski. Pedro Antônio Gabriel.

Effects of Mg/Ga and V/III source ratios on hole concentration of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy

Science.gov (United States)

Nonoda, Ryohei; Shojiki, Kanako; Tanikawa, Tomoyuki; Kuboya, Shigeyuki; Katayama, Ryuji; Matsuoka, Takashi

2016-05-01

The effects of growth conditions such as Mg/Ga and V/III ratios on the properties of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy were studied. Photoluminescence spectra from Mg-doped GaN depended on Mg/Ga and V/III ratios. For the lightly doped samples, the band-to-acceptor emission was observed at 3.3 eV and its relative intensity decreased with increasing V/III ratio. For the heavily doped samples, the donor-acceptor pair emission was observed at 2.8 eV and its peak intensity monotonically decreased with V/III ratio. The hole concentration was maximum for the Mg/Ga ratio. This is the same tendency as in group-III polar (0001) growth. The V/III ratio also reduced the hole concentration. The higher V/III ratio reduced the concentration of residual donors such as oxygen by substituting nitrogen atoms. The surface became rougher with increasing V/III ratio and the hillock density increased.

Idiopathic factor VIII inhibitor autoantibody in a man presented after accident.

NARCIS (Netherlands)

Mansouritorghabeh, H.; Lak, M.; Heerde, W.L. van

2009-01-01

Acquired hemophilia A is a rare but severe autoimmune bleeding disorder caused by autoantibodies against factor VIII activity and is a potentially life-threatening hemorrhagic disorder. The incidence of acquired hemophilia A has been estimated as 1.48 cases per million per year. The overall rate of

Infection control in anaesthesia in regional, tertiary and central ...

African Journals Online (AJOL)

2012-09-10

Sep 10, 2012 ... King Edward VIII Hospital; Nelson R Mandela School of Medicine, University of KwaZulu-Natal ... Samuel R, MBChB, DipHIVMan, FCPath(Viro)(SA), Specialist Virologist, Inkosi Albert Luthuli ... 12 regional level hospitals.

La restauración en comunidad de la iglesia de San Pedro de Atacama

Directory of Open Access Journals (Sweden)

Beatriz Yuste Miguel

2017-12-01

Full Text Available En medio del gran desierto de Atacama caracterizado por una gran aridez y amplitud térmica, se ubica en un fértil oasis, la iglesia de San Pedro de Atacama. Su construcción original dataría del siglo XVI, la actual, del siglo XVIII, conserva el estilo arquitectónico barroco del ámbito sur andino. La obra está sorprendentemente adecuada a la ecología, sismicidad y materialidad del desierto. Destacan sus muros de adobe, techumbre de par y nudillo de chañar y entablado de cactus. La iglesia ha sufrido sucesivos incendios, sismos, inundaciones y sobrecargas en el techo que han ido provocando daños acumulativos graves en su estructura. El proyecto de restauración ejecutado por Fundación Altiplano buscó ajustarse a los criterios y técnicas vigentes para la conservación patrimonial de construcciones en tierra, como también a los de preservación del patrimonio y desarrollo sostenible, a través del fortalecimiento de la comunidad de San Pedro de Atacama.

One-electron spectrum of Xe VIII

International Nuclear Information System (INIS)

Roberts, J.R.; Knystautas, E.J.; Sugar, J.

1979-01-01

The spectrum of Xe VIII has been observed in a theta-pinch discharge. New line identifications were made that determine the energies of the 6s, 7s, 6p, and 5f terms relative to the 5s 2 S ground state and confirm the previously known 5p and 5d terms. An independent system of levels derived from the observed 4f-ng (n = 5,6) transitions was found. Its position relative to the ground state is obtained from a predicted value for the 5g effective quantum number n*. From the ns series (n=5--7) a value for the ionization enegy of 105.91 +- 0.05 eV was derived

The 4p5rd10 and 4d86p configurations of Te VIII

International Nuclear Information System (INIS)

Churilov, S.S.; Rossijskaya Akademiya Nauk, Troitsk; Joshi, Y.N.; Kildiyarova, R.R.

1998-01-01

The spectrum of tellurium was photographed in the 100-500 A region on a variety of grazing incidence spectrographs using a triggered spark source. The analysis of the lines in the 117-216 A region has lead to establishing 42 out of 45 levels of the 4d 8 6p configuration of Te VIII. Four levels of the 4d 8 4f configuration were confirmed and their level values revised, and an additional 4d 8 4f level was established. The 4p 5 4d 10 levels reported earlier were found to be erroneous and new values have been found for them. Eighty seven (87) new lines have been classified in the (4d 9 + 4d 8 5s)-(4d 8 4f + 4p 5 4d 10 + 4d 8 6p) transition array. Hartree-Fock with relativistic corrections (HFR) and parametric least-squares-fitted (lSF) calculations were carried out to interpret the present analysis adequately. (orig.)

Development of a shared vision for groundwater management to protect and sustain baseflows of the Upper San Pedro River, Arizona, USA

Science.gov (United States)

Richter, Holly E.; Gungle, Bruce; Lacher, Laurel J.; Turner, Dale S.; Bushman, Brooke M.

2014-01-01

Groundwater pumping along portions of the binational San Pedro River has depleted aquifer storage that supports baseflow in the San Pedro River. A consortium of 23 agencies, business interests, and non-governmental organizations pooled their collective resources to develop the scientific understanding and technical tools required to optimize the management of this complex, interconnected groundwater-surface water system. A paradigm shift occurred as stakeholders first collaboratively developed, and then later applied, several key hydrologic simulation and monitoring tools. Water resources planning and management transitioned from a traditional water budget-based approach to a more strategic and spatially-explicit optimization process. After groundwater modeling results suggested that strategic near-stream recharge could reasonably sustain baseflows at or above 2003 levels until the year 2100, even in the presence of continued groundwater development, a group of collaborators worked for four years to acquire 2250 hectares of land in key locations along 34 kilometers of the river specifically for this purpose. These actions reflect an evolved common vision that considers the multiple water demands of both humans and the riparian ecosystem associated with the San Pedro River.

Development of a Shared Vision for Groundwater Management to Protect and Sustain Baseflows of the Upper San Pedro River, Arizona, USA

Directory of Open Access Journals (Sweden)

Holly E. Richter

2014-08-01

Full Text Available Groundwater pumping along portions of the binational San Pedro River has depleted aquifer storage that supports baseflow in the San Pedro River. A consortium of 23 agencies, business interests, and non-governmental organizations pooled their collective resources to develop the scientific understanding and technical tools required to optimize the management of this complex, interconnected groundwater-surface water system. A paradigm shift occurred as stakeholders first collaboratively developed, and then later applied, several key hydrologic simulation and monitoring tools. Water resources planning and management transitioned from a traditional water budget-based approach to a more strategic and spatially-explicit optimization process. After groundwater modeling results suggested that strategic near-stream recharge could reasonably sustain baseflows at or above 2003 levels until the year 2100, even in the presence of continued groundwater development, a group of collaborators worked for four years to acquire 2250 hectares of land in key locations along 34 kilometers of the river specifically for this purpose. These actions reflect an evolved common vision that considers the multiple water demands of both humans and the riparian ecosystem associated with the San Pedro River.

Pedro Duque suits up for TCDT

Science.gov (United States)

1998-01-01

STS-95 Mission Specialist Pedro Duque of Spain, representing the European Space Agency (ESA) is checked by Danny Wyatt (left), with KSC, and Dave Martin (right), with United Space Alliance, in the white room before entry into Space Shuttle Discovery for a pre-launch countdown exercise. Duque and other crew members are at KSC to participate in the Terminal Countdown Demonstration Test (TCDT) which includes mission familiarization activities, emergency egress training, and a simulated main engine cutoff. The other crew members are Payload Specialist Chiaki Mukai (M.D., Ph.D.), representing the National Space Development Agency of Japan (NASDA), Pilot Steven W. Lindsey, Mission Specialist Scott E. Parazynski, Mission Specialist Stephen K. Robinson, Payload Specialist John H. Glenn Jr., senator from Ohio, and Mission Commander Curtis L. Brown. The STS-95 mission, targeted for liftoff on Oct. 29, includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process. Following the TCDT, the crew will be returning to Houston for final flight preparations.

46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code.

Science.gov (United States)

2010-10-01

... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure Vessel...

Influence of Problem Based Learning on Critical Thinking Skills and Competence Class VIII SMPN 1 Gunuang Omeh, 2016/2017

Science.gov (United States)

Aswan, D. M.; Lufri, L.; Sumarmin, R.

2018-04-01

This research intends to determine the effect of Problem Based Learning models on students' critical thinking skills and competences. This study was a quasi-experimental research. The population of the study was the students of class VIII SMPN 1 Subdistrict Gunuang Omeh. Random sample selection is done by randomizing the class. Sample class that was chosen VIII3 as an experimental class given that treatment study based on problems and class VIII1 as control class that treatment usually given study. Instrument that used to consist of critical thinking test, cognitive tests, observation sheet of affective and psychomotor. Independent t-test and Mann Whitney U test was used for the analysis. Results showed that there was significant difference (sig competences.

Safety, efficacy and pharmacokinetics of rVIII-SingleChain in children with severe hemophilia A: results of a multicenter clinical trial.

Science.gov (United States)

Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I

2017-04-01

Essentials rVIII-SingleChain is a novel recombinant factor VIII with covalently bonded heavy and light chains. Efficacy, safety and pharmacokinetics were studied in pediatric patients with severe hemophilia A. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00. rVIII-SingleChain showed excellent hemostatic efficacy and a favorable safety profile. Background rVIII-SingleChain is a novel B-domain truncated recombinant factor VIII (rFVIII) comprised of covalently bonded FVIII heavy and light chains, demonstrating a high binding affinity to von Willebrand factor. Objectives This phase III study investigated the safety, efficacy and pharmacokinetics of rVIII-SingleChain in previously treated pediatric patients hemophilia A. Patients/Methods Patients could be assigned to prophylaxis or on-demand therapy by the investigator. For patients assigned to prophylaxis, the treatment regimen and dose were based on the bleeding phenotype. For patients receiving on-demand therapy, dosing was guided by World Federation of Hemophilia recommendations. The primary endpoint was treatment success, defined as a rating of 'excellent' or 'good' on the investigator's clinical assessment of hemostatic efficacy for all treated bleeding events. Results The study enrolled 84 patients (0 to 50 EDs. In the 347 bleeds treated and evaluated by the investigator, hemostatic efficacy was rated as excellent or good in 96.3%. The median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.00, 2.20), and the median annualized bleeding rate was 3.69 (Q1, Q3: 0.00, 7.20) across all prophylaxis regimens. No participant developed an inhibitor. Conclusions rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy and a favorable safety profile in a clinical study in children hemophilia A. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and

Chaos in long-term behavior of some Bianchi-type VIII models

Energy Technology Data Exchange (ETDEWEB)

Halpern, P

1987-01-01

The long-term behavior of Bianchi-type VIII models with three different types of stress-energy tensors are examined and compared. The vacuum model, a matter-filled model, and a model with an electromagnetic field are considered. In each case the existence of chaotic behavior and transitions to chaotic behavior are discussed.

Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Science.gov (United States)

Lozier, Jay N; Kloos, Mark T; Merricks, Elizabeth P; Lemoine, Nathaly; Whitford, Margaret H; Raymer, Robin A; Bellinger, Dwight A; Nichols, Timothy C

2016-01-01

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with recurrent soft-tissue hemorrhage and hemarthrosis was diagnosed with severe hemophilia A (factor VIII activity less than 1% of normal). We purified genomic DNA from this dog and ruled out the common intron 22 inversion; we then sequenced all 26 exons. Comparing the results with the normal canine factor VIII sequence revealed a C→T transition in exon 12 of the factor VIII gene that created a premature stop codon at amino acid 577 in the A2 domain of the protein. In addition, 2 previously described polymorphisms that do not cause hemophilia were present at amino acids 909 and 1184. The hemophilia mutation creates a new TaqI site that facilitates rapid genotyping of affected offspring by PCR and restriction endonuclease analyses. This mutation is analogous to the previously described human factor VIII mutation at Arg583, which likewise is a CpG dinucleotide transition causing a premature stop codon in exon 12. Thus far, despite extensive treatment with factor VIII, this dog has not developed neutralizing antibodies (‘inhibitors’) to the protein. This novel mutation in a dog gives rise to severe hemophilia A analogous to a mutation seen in humans. This model will be useful for studies of the treatment of hemophilia. PMID:27780008

Synthesis of dispersive iron or iron–silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

Energy Technology Data Exchange (ETDEWEB)

Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min, E-mail: yuhm@tsinghua.edu.cn [Tsinghua University, Key Laboratory of Industrial Biocatalysis of the Ministry of Education, Department of Chemical Engineering (China)

2015-10-15

M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with ∼2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5–10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant (∼85 %). ZVFe–Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl{sub 2} and AgNO{sub 3} solution before reduction.

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

NARCIS (Netherlands)

van den Biggelaar, M.; Bouwens, E.A.M.; Kootstra, N.A.; Hebbel, R.P.; Voorberg, J.; Mertens, K.

2009-01-01

Background Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

NARCIS (Netherlands)

van den Biggelaar, Maartje; Bouwens, Eveline A. M.; Kootstra, Neeltje A.; Hebbel, Robert P.; Voorberg, Jan; Mertens, Koen

2009-01-01

Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this study, we

The Effect of Growth Temperature and V/III Flux Ratio of MOCVD Antimony Based Semiconductors on Growth Rate and Surface Morphology

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Ramelan Ari Handono

2017-01-01

Full Text Available Epitaxial Alx Ga1-x Sb layers on GaSb and GaAs substrates have been grown by atmospheric pressure metalorganic chemical vapor deposition using TMAl, TMGa and TMSb. Nomarski microscope and a profiler were employed to examine the surface morphology and growth rate of the samples. We report the effect of growth temperature and V/III flux ratio on growth rate and surface morphology. Growth temperatures in the range of 520°C and 680°C and V/III ratios from 1 to 5 have been investigated. A growth rate activation energy of 0.73 eV was found. At low growth temperatures between 520 and 540°C, the surface morphology is poor due to antimonide precipitates associated with incomplete decomposition of the TMSb. For layers grown on GaAs at 580°C and 600°C with a V/III ratio of 3 a high quality surface morphology is typical, with a mirror-like surface and good composition control. It was found that a suitable growth temperature and V/III flux ratio was beneficial for producing good AlGaSb layers. Undoped AlGaSb grown at 580°C with a V/III flux ratio of 3 at the rate of 3.5 μm/hour shows p-type conductivity with smooth surface morphology

New Data on the Life of the Peruvian-Bolivian Composer Pedro Ximénez-Abrill Tirado (1784-1856

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José Manuel Izquierdo König

2017-07-01

Full Text Available Since the mid-nineteenth century the name of Pedro Ximénez Abrill Tirado has been known in musicological and historiographical studies. However, his role and relevance as composer has been acknowledged only recently in the study of historical repertoires of South America, with the discovery of scores containing his music in a private collection in Bolivia, which was later acquired by various archives and individuals. In spite of this, biographical accounts on him have kept using the same information for decades, and mythical constructions have increased rapidly during the last decade. This paper presents a new biographical picture of Pedro Ximénez, with a broader understanding of the context surrounding his life and works along with the transition of his life between Peru and Bolivia, on the basis of important new sources gathered by both authors through research in various archives.

Dos precursores: D. Pedro Fermín de Vargas y D. Antonio Nariño

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Roberto Tisnés

1962-02-01

Full Text Available Se cumple en el presente año –el 3 de julio exactamente-el bicentenario del nacimiento del notable Precursor de la Independencia D. Pedro Fermín de Vargas. Como anticipo de la biografía que para esa fecha verá la luz pública, nos permitimos publicar uno de los capítulos de la primera parte.

Living in a physical world VIII. Gravity and life in water

Indian Academy of Sciences (India)

2006-07-31

Jul 31, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 3. Living in a physical world VIII. Gravity and life in water. Steven Vogel. Series Volume 31 Issue 3 September 2006 pp 309-322. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/031/03/0309-0322 ...

Absorption signatures of warm-hot gas at low redshift : Ne VIII

NARCIS (Netherlands)

Tepper-García, T

2013-01-01

At z {lt} 1 a large fraction of the baryons is thought to reside in diffuse gas that has been shock-heated to high temperatures (10$^{5}$-10$^{6}$ K). Absorption by the 770.41, 780.32 å doublet of Ne VIII in quasar spectra represents a unique tool to study this elusive warm-hot phase. We have

Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.

Science.gov (United States)

Johnson, D J; Pemberton, S; Acquila, M; Mori, P G; Tuddenham, E G; O'Brien, D P

1994-04-01

A novel CRM+ mutation, factor VIII position 373 serine to leucine substitution (FVIII 373-Leu) was identified during a survey of Factor VIII (FVIII) mutations. We have purified the variant protein from the patient's plasma in order to allow further characterisation of the molecule. The CRM+ plasma contained 120% Factor VIII antigen (FVIII:Ag) and 6% Factor VIII coagulant activity (FVIII:C). After purification the mutant FVIII was subjected to thrombin proteolysis, and was thereby activated 5.6-fold compared with 7-fold for wild type molecule. Subsequently, spontaneous inactivation of the mutant was much slower than noted for wild type FVIII. Western blot analysis using monoclonal antibodies demonstrated that thrombin cleavage of FVIII 373-Leu at positions 740 and 1689 were normal but that cleavage at position 372 was completely absent. Crystallographic coordinates of the active site of thrombin complexed to fibrinopeptide A were used to explore possible mechanistic reasons for the failure of thrombin to cleave the mutant FVIII at position 372. Steric hindrance between the mutant side chain and the side chain of the P1 residue was apparent. We conclude that the functional defect of FVIII 373-Leu results from the inability of thrombin to cleave the mutant at position 372-373, and propose that this is due to steric hindrance by the side chain of leucine 373, preventing correct formation of the enzyme substrate complex.

The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement?

Science.gov (United States)

Josephson, Cassandra D; Abshire, Thomas

2004-07-01

The goal of eliminating the low levels of infectious disease risk from hemophilia treatment has resulted in the development of multiple generations of recombinant factor VIII (rFVIII) products. The ideal product should be devoid of human and animal proteins, which may transmit infectious agents. These products should also maintain molecular integrity, hemostatic efficacy, similar immunogenicity, and acceptable side effect profiles as compared to plasma-derived factor VIII. Currently available first-, second-, and third-generation rFVIII products include Recombinate; Kogenate FS/Helixate FS and ReFacto; and Advate, respectively. During the evolution of rFVIII products, either full-length or B-domain-deleted factor VIII were transfected into immortalized cell lines. The B-domain-deleted product, ReFacto, has resulted in an additional method to monitor factor VIII levels. The third-generation products offer the theoretical advantage of being produced without human and/or animal proteins. Upon initial introduction into the marketplace, the newer products have a higher cost. However, when analyzing historical trends, the prices of these products are almost equivalent to first-generation products within 3 years of licensure. Thus, the initial cost of the product may be a minimal issue in the medical decision process when selecting rFVIII replacement therapy.

Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

Indian Academy of Sciences (India)

In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the ... The self-bound state appears to be at ρ ... The observations suggest that the Hubble expansion of the Universe ... Taking motivation from.

Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII

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Marcela Cristina Correa de Freitas

2014-06-01

Full Text Available OBJECTIVE: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO and baby hamster kidney cells (BHK. Previous studies, using the murine leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two recombinant human cell lines, HepG2 and Hek293 to produce recombinant factor VIII. In order to characterize these cells, the present study aimed to analyze the integration pattern of retroviral vector pMFG-FVIII-P140K.METHODS: This study used ligation-mediated polymerase chain reaction to locate the site of viral vector integration by sequencing polymerase chain reaction products. The sequences were compared to genomic databases to characterize respective clones.RESULTS: The retroviral vector presented different and non-random profiles of integration between cells lines. A preference of integration for chromosomes 19, 17 and 11 was observed for HepG2FVIIIdB/P140K and chromosome 9 for Hek293FVIIIdB/P140K. In genomic regions such as CpG islands and transcription factor binding sites, there was no difference in the integration profiles for both cell lines. Integration in intronic regions of encoding protein genes (RefSeq genes was also observed in both cell lines. Twenty percent of integrations occurred at fragile sites in the genome of the HepG2 cell line and 17% in Hek293.CONCLUSION: The results suggest that the cell type can affect the profile of chromosomal integration of the retroviral vector used; these differences may interfere in the level of expression of recombinant proteins.

PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

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Apri Dwi Astuti

2012-10-01

Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

Leonor Plantagenet y la consolidación castellana en el reinado de Alfonso VIII

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Cerda, José Manuel

2012-12-01

Full Text Available The kingdom of Castile experienced a process of political and territorial consolidation between the death of Sancho III in 1158 and the Curia of Carrión de los Condes in 1188, leaving behind the troublesome minority of Alfonso VIII and the subordination to the kingdom of Leon, and thus becoming a dominant power within the peninsula, and one that achieved considerable success in the Reconquest. The following article is part of a biographical approach to Eleanor Plantagenet, queen consort of Alfonso VIII, and by means of a specifi c focus offers an analysis of the role played by the English queen in this process of political consolidation of Castile. As we approach the eighth centenary of her death, the life and work of this little-studied woman emerges as a testimony to the important diplomatic and cultural tasks assumed by queens in twelfth-century Europe.

Desde la muerte de Sancho III en 1158 a la Curia de Carrión de los Condes en 1188, el reino castellano experimentó una consolidación política y territorial que dejó atrás la problemática minoría de Alfonso VIII y la subordinación al reino de León, que lo constituyó en un poder dominante dentro de la península y que logró un avance importante en la empresa reconquistadora. El presente trabajo es parte de un acercamiento biográfico a Leonor Plantagenet, consorte de Alfonso VIII, y que por medio de un enfoque particular ofrece un análisis de la incidencia que tuvo la reina inglesa en este proceso de afianzamiento político de Castilla. En las vísperas del octavo centenario de su muerte, la vida y obra de esta mujer hasta ahora poco estudiada, surge como un testimonio importante a la labor diplomática y cultural que asumían las reinas en la Europa del siglo XII.

Transient electromagnetic study of basin fill sediments in the Upper San Pedro Basin, Mexico

Science.gov (United States)

Bultman, M.W.; Gray, F.

2011-01-01

The Upper San Pedro River Basin in Mexico and the United States is an important riparian corridor that is coming under increasing pressure from growing populations and the associated increase in groundwater withdrawal. Several studies have produced three-dimensional maps of the basin fill sediments in the US portion of the basin but little work has been done in the Mexican portion of the basin. Here, the results of a ground-based transient electromagnetic (TEM) survey in the Upper San Pedro Basin, Mexico are presented. These basin fill sediments are characterized by a 10-40 m deep unsaturated surficial zone which is composed primarily of sands and gravels. In the central portion of the basin this unsaturated zone is usually underlain by a shallow clay layer 20-50 m thick. Beneath this may be more clay, as is usually the case near the San Pedro River, or interbedded sand, silt, and clay to a depth of 200-250 m. As you move away from the river, the upper clay layer disappears and the amount of sand in the sediments increases. At 1-2 km away from the river, sands can occupy up to 50% of the upper 200-250 m of the sediment fill. Below this, clays are always present except where bedrock highs are observed. This lower clay layer begins at a depth of about 200 m in the central portion of the basin (250 m or more at distances greater than 1-2 km from the river) and extends to the bottom of most profiles to depths of 400 m. While the depth of the top of this lower clay layer is probably accurate, its thickness observed in the models may be overestimated due to the relatively low magnetic moment of the TEM system used in this study. The inversion routine used for interpretation is based on a one-dimensional geologic model. This is a layer based model that is isotropic in both the x and y directions. Several survey soundings did not meet this requirement which invalidates the inversion process and the resulting interpretation at these locations. The results from these

Mineração, turismo e ambiente em Pedro II, Piauí

OpenAIRE

Gomes, Divamélia de Oliveira Bezerra [UNESP

2011-01-01

Pedro II, desde a década de 50 vem sofrendo alteração da paisagem natural em decorrência da exploração de opala e nos últimos cinco anos pelo ecoturismo emergente, não planejado e estruturado. O presente trabalho analisou os impactos sócio-ambientais decorrentes da atividade de garimpo de opala e da ação do turismo em áreas naturais, bem como vem a propor ações efetivas para desenvolvimento destas atividades de forma sustentável no município. Para consecução dos objetivos propostos, a pesquis...

"Palabras de la Ciencia": Pedro Castera and Scientific Writing in Mexico's "Fin de Siècle"

Science.gov (United States)

del Pilar Blanco, María

2014-01-01

This essay explores the career of the understudied writer Pedro Castera (1846-1906), who is regarded as one of the first practitioners of science fiction in Mexico. A man of many talents, Castera is one of the most eccentric and eclectic figures in the intellectual life of fin-de-siècle Mexico City. His career took many turns: While during…

San Pedro de la Paz: elementos del patrimonio natural estructurantes del paisaje urbano, seccional El Venado

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Leonel Pérez Bustamante

2003-09-01

Full Text Available El proyecto Plan Seccional El Venado se circunscribe en la intención de desarrollar un proyecto inmobiliario de gran extensión territorial en las mesetas de la Cordillera de Nahuelbuta, comuna de San Pedro de la Paz, en el denominado fundo El Venado.

De reescrituras y obsesiones. La cicatriz y La voz de Mallick (1981, de Pedro Casariego Córdoba

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Raúl Díaz Rosales

2012-01-01

Full Text Available En este trabajo se presenta una breve introducción a la recepción de la obra de Pedro Casariego Córdoba, así como a sus coordenadas estéticas, donde se establece su legado literario como una obsesión de ciertos elementos que vertebran su escritura. En el análisis del libro de poemas La voz de Mallick y la obra de teatro La cicatriz (de 1981 ambas, se constatará este hecho, al ser ambas creaciones dos visiones de un mismo tema: la liberación del condenado a través del amor. This paper focuses on the reception of Pedro Casariego Córdoba’s work, including his aesthetic coordinates, where he establishes his literary legacy as well as the obsession about some elements that build his writings. In the analysis of the poem La voz de Mallick and the play La cicatriz (both written in 1981, this fact will be proved, being these two creations visions of the same theme: the convicted’s liberation with the help of love.

O ensino da psiquiatria e o poder disciplinar da enfermagem religiosa: o hospício de Pedro II no segundo reinado

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Maria Angélica de Almeida Peres

2011-01-01

Full Text Available El estudio tiene como objetivos: describir las relaciones entre la enseñanza de la psiquiatría y el poder disciplinar de las Hermanas de la Caridad del Hospicio de Pedro II; analizar las circunstancias en que se realizó el concurso que eligió el primer Catedrático de Psiquiatría de la Facultad de Medicina de Rio de Janeiro; discutir las repercusiones para el poder disciplinar ejercido por las Hermanas de la Caridad del Hospicio de Pedro II. Es un estudio de carácter histórico y documental en el que se analizan libros administrativos de la Santa Casa de Misericordia y los artículos del Jornal do Comércio, con base en el referencial foucaultiano. El concurso para Catedrático de Psiquiatría, aunque duramente cuestionado por la prensa, eligió un médico opositor a la administración del Hospicio de Pedro II por la Santa Casa de Misericordia. Tras su ingreso como director del hospicio, ese catedrático comenzó una reforma administrativa, lo que lleva a la progresiva reducción de la actividad religiosa y la consiguiente reducción de los cuidados de enfermería en ese espacio, lo que permite su medicalización.

Complexation of the cesium cation with lithium ionophore VIII: extraction and DFT study

Czech Academy of Sciences Publication Activity Database

Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

2013-01-01

Roč. 298, č. 3 (2013), s. 2065-2068 ISSN 0236-5731 Institutional support: RVO:61388963 Keywords : cesium cation * lithium ionophore VIII * complexation * extraction and stability constants * water-nitrobenzene system * DFT calculations * structures Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.415, year: 2013

A morte como elemento cultural mexicano em Pedro Páramo, de Juan Rulfo

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Ana Paula Cantarelli

2013-06-01

Full Text Available Pedro Páramo (1955, de Juan Rulfo, desde sua publicação tem sido alvo de inúmeros estudos desenvolvidos por pesquisadores de diferentes áreas do conhecimento (história, sociologia, filosofia, etc.. Neste texto, buscou-se elaborar uma proposta de leitura a partir do reconhecimento da morte, símbolo nacional mexicano, como um elemento constituinte da estrutura narrativa desse romance, com a intenção de ampliar o campo de análises já delineado ao redor dessa obra.

Examining the life history of an individual from Solcor 3, San Pedro de Atacama: Combining bioarchaeology and archaeological chemistry

International Nuclear Information System (INIS)

Torres-Rouff, Cristina; Knudson, Kelly J

2007-01-01

Detailed life history information using multiple lines of evidence including the identification of geographic origins, health, and body use indicators, can be used to elucidate the complex process of acculturation in the San Pedro de Atacama oases of northern Chile during the Middle Horizon. This paper presents the results of bioarchaeological and archaeological chemical analyses of the skeletal remains of an adult male (tomb 50, catalog number 1948) from the cemetery of Solcor 3 (ca. AD 500-900). Strontium isotope ratios in human tooth enamel reveal information about where a person lived during their childhood, when enamel was being formed. Individual 1948 showed strontium isotope ratios decidedly outside the range of the local San Pedro de Atacama strontium isotope signature. Given these data implying that individual 1948 was originally from elsewhere, an examination of his health status, social role, and mortuary context provides insight into the treatment of foreigners in San Pedro de Atacama. Our data support the argument that individual 1948's foreign birth did not hinder his later assimilation into Atacameno society. He was buried in a local cemetery with a typical mortuary assemblage for a male of this time and no strong evidence of possible foreign origin. Skeletal indicators of diet and activity patterns do not distinguish individual 1948 from the local population, suggesting that his lifestyle was similar to that of other Atacamenos. Therefore, our analyses suggest that individual 1948's acculturation into Atacameno society during his adult life was nearly complete and he retained little to no indication of his probable foreign birth

Structure and stability of hexa-aqua V(III) cations in vanadium redox flow battery electrolytes.

Science.gov (United States)

Vijayakumar, M; Li, Liyu; Nie, Zimin; Yang, Zhenguo; Hu, JianZhi

2012-08-07

The vanadium(III) cation structure in mixed acid based electrolyte solution from vanadium redox flow batteries is studied by (17)O and (35/37)Cl nuclear magnetic resonance (NMR) spectroscopy, electronic spectroscopy and density functional theory (DFT) based computational modelling. Both computational and experimental results reveal that the V(III) species can complex with counter anions (sulfate/chlorine) depending on the composition of its solvation sphere. By analyzing the powder precipitate it was found that the formation of sulfate complexed V(III) species is the crucial process in the precipitation reaction. The precipitation occurs through nucleation of neutral species formed through deprotonation and ion-pair formation process. However, the powder precipitate shows a multiphase nature which warrants multiple reaction pathways for precipitation reaction.

KEANEKARAGAMAN HYMENOPTERA PARASITOID PADA PERKEBUNAN KELAPA SAWIT PTPN VIII CINDALI, BOGOR

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Ichsan Luqmana Indra Putra

2016-09-01

Full Text Available Diversity of parasitic Hymenoptera in PTPN VIII oil palm plantation Cindali, Bogor. One group of important natural enemies in oil palm plantation is parasitic Hymenoptera. The purpose of this research is to know the diversity and fluctuation of parasitic Hymenoptera PTPN VIII Cindali oil palm plantation. This research was conducted in 6 blocks of oil palm in September 2014 – June 2015. There were 5 plots in every observation blocks 39.2 x 39.2 m in size, and used direct and indirect method. Direct method done by 5 plants in every plots was taken randomized to observed and taken the herbivore insects to reared until the parasitic Hymenoptera came out. Observation of cover crops conducted by 3 subplots determined diagonally in every plots 9.8 x 9.8 m in size and herbivore insects was observed and collected. Indirect methods used sweep net and yellow pan trap. The result of this research, 26 parasitic Hymenoptera families was found, with the Braconidae was the most morphospecies found and the most individual amount was Scelionidae. The abundance of parasitoid in every month fluctuated.

Investigating Historic Parcel Changes to Understand Land Use Trends: A Methodology and Application for the San Pedro River Watershed

Science.gov (United States)

Long-term land use and land cover change, and the associated impacts, pose critical challenges to sustaining healthy communities and ecosystems. In this study, a methodology was developed to use parcel data to evaluate land use trends in southeast Arizona’s San Pedro River Water...

Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

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Cacilda Joyce Ferreira da Silva Garcia

Full Text Available OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoquímica pelo método da estreptoavidina-biotina-peroxidase e utilizados os marcadores tumorais CD-34 e Fator VIII. Após este processo as lâminas foram submetidas à leitura no sistema Samba 4000® e avaliadas pelo software Immuno®. Os parâmetros estudados foram: índice de marcagem e densidade óptica, expressos por médias, medianas, valores mínimos, valores máximos e desvios-padrão, analisados estatisticamente. RESULTADOS: Para o marcador CD-34 não houve normalidade dos dados em relação ao índice de marcagem e houve para a densidade óptica. Para o Fator VIII, houve normalidade de dados em relação ao índice de marcagem e para a densidade óptica. CONCLUSÃO: Foi possível quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII através do índice de marcagem e da densidade óptica média; não houve diferença entre os marcadores em relação à média do índice de marcagem e da densidade óptica, não sendo possível definir superioridade entre um e outro; não foi observada tendência à correlação quando comparados densidade óptica e índice de marcagem do Fator VIII e do CD-34 isoladamente estudados; não houve correlação entre o índice de marcagem do Fator VIII quando comparado com o CD-34, bem como a densidade óptica do Fator VIII com o CD-34.

STS-95 Mission Specialist Pedro Duque suits up for launch

Science.gov (United States)

1998-01-01

STS-95 Mission Specialist Pedro Duque of Spain, with the European Space Agency, is helped with his flight suit by suit tech Tommy McDonald in the Operations and Checkout Building. The final fitting takes place prior to the crew walkout and transport to Launch Pad 39B. Targeted for launch at 2 p.m. EST on Oct. 29, the mission is expected to last 8 days, 21 hours and 49 minutes, and return to KSC at 11:49 a.m. EST on Nov. 7. The STS-95 mission includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

Indian Academy of Sciences (India)

In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the context of general relativity are explored. To obtain deterministic solution of the Einstein's field equations, various techniques are adopted. The features of the obtained solution are discussed.

Safety and Efficacy of BAY 94-9027, a Prolonged-Half-Life Factor VIII

DEFF Research Database (Denmark)

Reding, M T; Ng, H J; Poulsen, Lone Hvitfeldt

2017-01-01

BACKGROUND: BAY 94-9027 is a B-domain-deleted prolonged-half-life recombinant factor VIII (FVIII) conjugates in a site-specific manner with polyethylene glycol. OBJECTIVE: Assess efficacy and safety of BAY 94-9027 for prophylaxis and treatment of bleeds in patients with severe hemophilia A PATIEN...

Fire-scar formation in Jeffrey pine - mixed conifer forests in the Sierra San Pedro Martir, Mexico

Science.gov (United States)

Scott L. Stephens; Danny L. Fry; Brandon M. Collins; Carl N. Skinner; Ernesto Franco-Vizcaino; Travis J. Freed

2010-01-01

Little is known about the probability of fire-scar formation. In this study, we examined all mixed conifer trees for fire-scar formation in a 16 ha watershed that burned as part of a 2003 wildfire in Sierra San Pedro Ma´rtir National Park (SSPM), Mexico. In addition, we examine the probability of fire-scar formation in relation to the previous fire interval in forests...

Origen del Palacio de Pedro I en el Alcázar de Sevilla: el mirador hoy llamado de los Reyes Católicos

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Fernández Aguilera, Sebastián

2015-12-01

Full Text Available This study originated with the search for the possible initial site of the main door of the Old Chapel, which, following its restoration and study, turned out to be older than the rest of the Mudéjar palace of King Pedro I (Seville, 1365. During this investigation, and based on recent studies carried out as the result of several previous restorations, the author realized that this door was not relocated from another place. It had formed part of the earlier Gothic palace to which the construction of Pedro I’s palace was attached at this juncture, with several rooms from basement to upper balcony predating the Mudéjar building, thereby concluding that it must have been the work of his father, King Alfonso XI.El presente trabajo, se inicia con la búsqueda del emplazamiento que pudo tener la gran puerta de la Antigua Capilla, de la que, tras su restauración y estudio, sabemos que existía con anterioridad a la obra mudéjar del palacio de Pedro I en Sevilla en 1365. En esa búsqueda, y apoyándonos en los distintos estudios que se vienen realizando con motivo de restauraciones recientes, hemos llegado a la conclusión de que no se trata de carpintería reutilizada, sino que es toda la construcción de esa parte del palacio, adosada al anterior palacio gótico, y con distintas estancias desde el sótano hasta el Mirador, la que ya existía con anterioridad al rey Don Pedro, y con toda probabilidad obra de su padre el rey Alfonso XI, como se concluye en este artículo.

Keefektifan Experiential Learning Berbantuan Origami Terhadap Kemampuan Keruangan Siswa Kelas VIII

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Isnaeni Umi Machromah

2014-11-01

Full Text Available AbstrakPenelitian eksperimen ini bertujuan untuk mengetahui keefektifan pembelajaran Experiential Learning berbantuan origami terhadap kemampuan keruangan siswa dengan kualifikasi keefektifan yang telah ditentukan. Populasi yaitu siswa kelas VIII SMP Negeri 3 Colomadu tahun pelajaran 2012/2013. Sampel diambil secara simple random sampling. Hasil penelitian ini yaitu: (1 Uji proporsi ketuntasan belajar menunjukkan siswa kelompok eksperimen telah mencapai ketuntasan belajar; (2 Uji perbedaan dua rata-rata menghasilkan simpulan bahwa rata-rata hasil post-test kemam-puan keruangan siswa kelompok eksperimen lebih dari kelompok kontrol; (3 Analisis re-gresi menunjukkan bahwa motivasi belajar siswa memberikan pengaruh positif sebesar 49,3% terhadap kemampuan keruangan siswa; (4 Uji gain ternormalisasi menunjukkan terdapat peningkatan kemampuan keruangan siswa secara signifikan pada kategaori sedang untuk kelompok eksperimen dan kategori rendah untuk kelompok kontrol. Simpulan yang diperoleh yaitu Experiential Learning berbantuan origami efektif terhadap kemampuan keruangan siswa kelas VIII. AbstractThis experiment research aims to determine the effectiveness of Experiential Learning with Origami to the students’s spatial abilities by the criteria of effectiveness. The population of this research is students of grade VIII of SMP Negeri 3 Colomadu 2012/2013 academic year. Independent variables used in this research are learning by Experiential Learning with origami and student’s motivation. While the dependent variable is the student’s spatial abilities. This research is using documentation, spatial abilities’s test, dan motivation’s scale for collecting data method. Result of this research are: (1 proportion test show that the experiment group has reached mastering of learning clasically and personally; (2 result of spatial ablities’s post test in experiment group better than control group; (3 result of regretion shows that student�

Arhitektuur, võrgukultuur ja kuidas neist kasu saada = Architecture, networked cultures and how to make the most of them / Pedro Gadanho

Index Scriptorium Estoniae

Gadanho, Pedro

2011-01-01

Arhitekt Pedro Gadanho vaatleb olulist aspekti kõikvõimalike sündmuste puhul - vahetut suhtlemist. Vaatamata internetiajastul virtuaalruumi kolinud inimestevahelisele läbikäimisele on õigete inimestega kohtumine iga sündmuse oluline osa

A zoologia filosófica no Brasil: explorando as modernas correntes do pensamento científico no Collégio de Pedro II em meados do século XIX - The philosophical zoology in Brazil: exploring the modern approaches of the scientific thinking in the d. Pedro sc

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Karl M. Lorenz

2011-04-01

Full Text Available Resumo As Ciências Naturais foram ensinadas na escola secundária pública brasileira a partir de 1837 com a fundação do Imperial Collégio de Pedro II no Rio de Janeiro. Em 1841 foi introduzida no currículo a Zoologia Filosófica, uma matéria teórica, complementar aos estudos tradicionais da Zoologia, que permaneceu até ser suprimida em 1855. A Zoologia Filosófica era uma matéria intrínseca ao Colégio de Pedro II, uma vez que não existia nos colégios brasileiros da época outra semelhante, nem mesmo nos liceus franceses. Embora não haja informações sobre os conteúdos de que tratava, tem-se o programa de exames de 1850, em que quarenta pontos são listados. Mediante uma análise dos pontos, foi possível identificar os conteúdos ensinados. A análise demonstra que, em contraste com os conceitos tradicionais da Zoologia Descritiva, a Zoologia Filosófica abordou conceitos, grandes teorias e especulações sobre a origem, as transformações e o crescimento dos animais, que circulavam na Europa, e particularmente na França, na primeira metade do século XIX. No estudo, constata-se que foi uma matéria excepcional por ser a única no Brasil a tratar da Zoologia teórica nos moldes da Naturalfilosofie, prevalecente na Alemanha e explorada na França por Étienne Geoffroy Saint-Hilaire, Étienne Serres e outros cientistas de renome. Palavras-chave: ensino de ciências; história natural; ensino secundário; história das disciplinas; Collégio de Pedro II.   THE PHILOSOPHICAL ZOOLOGY IN BRAZIL: EXPLORING THE MODERN APPROACHES OF THE SCIENTIFIC THINKING IN THE “D. PEDRO” SCHOOL AT THE BEGINNING OF THE XIX CENTURY Abstract The natural sciences were taught in the public secondary schools in Brazil beginning in 1837 with the founding of the Imperial College Pedro II in Rio de Janeiro. In 1841, the course, Philosophical Zoology, was introduced as a theoretical discipline that complimented the standard content taught in the more

Neurotology findings in patients with diagnosis of vascular loop of cranial nerves VIII in magnetic resonance imaging

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Grocoske, Francisco Luiz Busato

Full Text Available Introduction: The vascular compression by redundant vessels under the VIII cranial nerves has been studied since the 80's, and many authors proposed correlations between the compression and the otoneurological findings (vertigo, tinnitus, hypoacusis, audiometry and electrophysiological findings. Objective: Analyze and correlate the different signs and otoneurological symptoms, the audiological findings and its incidence over individuals with Vascular Loop (VL diagnosis of VIII cranial nerves by magnetic resonance imaging (MRI. Method: Retrospective study through the analysis of medical records of 47 patients attended in the otoneurology clinic of Clinical Hospital of UFPR. All the patients have MRI exams with compatible pictures of VL of the VIII cranial nerves. Results: The tinnitus was the most frequent symptom, in 83% of the patients, followed by hypoacusis (60% and vertigo (36%. The audiometry presented alterations in 89%, the brainstem evoked auditory potential in 33% and the vecto-electronystagmography in 17% of the patients. Was not found statistically significant relation between the buzz or hypoacusis, and the presence of VL in MRI. Only 36% of patients had complaints of vertigo, the main symptom described in theory of vascular compression of the VIII pair of nerve. As in the audiometry and in brainstem evoked auditory potential was not found a statistically significant relation between the exam and the presence of the VL in the RMI. Conclusion: The results show independence between the findings of the RMI, clinical picture and audiological results (p>0,05 suggesting that there are no exclusive and direct relation between the diagnosis of vascular loop in the MRI and the clinical picture matching.

The BOOTES-5 telescope at San Pedro Martir National Astronomical Observatory, Mexico

Science.gov (United States)

Hiriart, D.; Valdez, J.; Martínez, B.; García, B.; Cordova, A.; Colorado, E.; Guisa, G.; Ochoa, J. L.; Nuñez, J. M.; Ceseña, U.; Cunniffe, R.; Murphy, D.; Lee, W.; Park, Il H.; Castro-Tirado, A. J.

2016-12-01

BOOTES-5 is the fifth robotic observatory of the international network of robotic telescopes BOOTES (Burst Observer and Optical Transient Exploring Optical System). It is located at the National Astronomical Observatory at Sierra San Pedro Martir, Baja California, Mexico. It was dedicated on November 26, 2015 and it is in the process of testing. Its main scientific objective is the observation and monitoring of the optic counterparts of gamma-ray bursts as quickly as possible once they have been detected from space or other ground-based observatories. BOOTES-5 fue nombrado Telescopio Javier Gorosabel en memoria del astrónomo español Javier Gorosabel Urkia.

Valor preditivo da expressão dos anticorpos Antifator VIII no carcinoma epidermóide do esôfago Predictive value of antifactor VIII antibody expression in squamous cell carcinoma of the esophagus

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Sebastião Gonzaga Barbosa-Neto

2007-12-01

Full Text Available RACIONAL: O carcinoma epidermóide do esôfago apresenta alta mortalidade, baixo índice de diagnóstico precoce e altos custos nos tratamentos, com resultados freqüentemente desapontadores e prognóstico sombrio. O melhor entendimento das técnicas de biologia molecular com citofotometria de imagem, permitiu avançar no conhecimento das alterações na expressão das proteínas desse câncer. OBJETIVOS: Quantificar a expressão das proteínas envolvidas na angiogênese e correlacioná-las com variáveis clínico-patológicas. MÉTODOS: Com o uso da técnica de imunoistoquímica, citofotometria de imagem pelo sistema SAMBA, foram analisadas 29 amostras de carcinoma epidermóide do esôfago incluídas em blocos de parafina. Critérios clínicos como idade, sexo e histopatológicos do grau de diferenciação tumoral, tamanho e localização do tumor foram analisados. Os parâmetros analisados foram o índice de marcagem e a densidade óptica. O marcador utilizado foi o anticorpo anti-Fator VIII. RESULTADOS: Foi possível verificar que as expressões médias do marcador no índice de marcagem foram maiores que as da densidade óptica. Fator VIII apresentou leituras homogêneas. O índice de marcagem foi de 80,17+/-10,40 com P=0,073 e a densidade óptica 51,25+/-11,02 com P=0,245. CONCLUSÃO: A análise quantificação da expressão das proteínas envolvidas na angiogênese permite definir subgrupos de acordo com a diferenciação do carcinoma, estágio tumoral, tamanho e localização do tumor, porém não associa-se com o sexo e a idade dos pacientes, e a densidade óptica do Fator VIII não tem expressão significativa em nenhum dos subgrupos analisados.BACKGROUND: Squamous cell carcinoma of the esophagus exhibits high mortality rate, rare precocious diagnosis, and expensive treatments, presenting frequently disappointed results and poor prognosis. The better understanding about Molecular Biology techniques using cytophotometric imaging allowed

The spectrum of seven times ionized tungsten (W VIII) relevant to tokamak divertor plasmas

International Nuclear Information System (INIS)

Ryabtsev, A N; Kononov, E Ya; Kildiyarova, R R; Tchang-Brillet, W-Ü L; Wyart, J-F

2013-01-01

Tungsten spectra excited in the vacuum sparks of different setups and electric circuits were recorded on two high-resolution vacuum spectrographs. For the region 190–500 Å, a 10 m normal incidence spectrograph with a 3600 lines/mm grating was used in the Meudon Observatory. In the region below 350 Å, a set of spectra was produced using a 3 m grazing incidence spectrograph with a 3600 lines/mm grating in the Institute of Spectroscopy in Troitsk. A total of 187 lines in the region 160–271 Å were identified as transitions to the low-lying odd configurations 4f 13 5s 2 5p 6 and 4f 14 5s 2 5p 5 from the interacting excited even 4f 12 5s 2 5p 6 5d + 4f 13 5s 2 5p 5 (5d + 6s) + 4f 14 5s 2 5p 4 (5d + 6s) + 4f 14 5s5p 6 configurations. It was found that 4f 13 5s 2 5p 6 2 F 7/2 is the ground level of W VIII. The fine structure splitting and relative positions of the odd terms were established, and 98 levels of the excited even configurations were found. (paper)

Composición de la araneofauna en dos especies de árboles nativos Peumus boldus Mol. y Luma apiculata (D.C.) Burret en el parque botánico Pedro del río Zañartu (Hualpen), Concepción, VIII Región, Chile

OpenAIRE

Aguilera, Milenko A; Casanueva, María E; Hernández, Cristián E

2006-01-01

Además de la cercana relación entre composición comunitaria y recursos disponibles, la estructura física del bosque a menudo se ha citado como un factor importante que afecta los patrones de diversidad de artrópodos. El objetivo de este estudio fue evaluar el efecto de dos especies nativas de árbol, que difieren en su estructura física, sobre la diversidad de araneofauna en el Parque Botánico Pedro del Río Zañartu (Hualpén). Con este fin se estimó la abundancia, diversidad, semejanza y compos...

Penggunaan Media Presentase Microsoft Power Point Untuk Meningkatkan Hasil Belajar IPS Terpadu Pada Siswa Kelas VIII a SMP Negeri 2 Tanantovea

OpenAIRE

Hitler, Ahmad

2014-01-01

Permasalahan yang diangkat dalam penelitian adalah apakah dengan penggunaan media Presentase Microsoft Power Point pada mata pembelajaran IPS Terpadu dapat meningkatkan hasil belajar siswa kelas VIII A di SMP Negeri 2 Tanantovea. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada pokok bahasan Kolonialisme dan Imperialisme Barat di kelas VIII A SMP Negeri 2 Tanantovea. Penelitian ini dilakukan dalam 2 siklus, setiap siklus terdiri dari perencanaan, pelaksanaan tindakan, obs...

Datos para una biografía del jurista Pedro Murillo Velarde y Bravo

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Luis Díaz de la Guardia y López

2001-01-01

Full Text Available En el presente artículo se pretende aportar una serie de coordenadas para fijar la vida y el pensamiento de Pedro Murillo Velarde y Bravo (Laujar 1696-Puerto de Santa María 1753. Hidalgo de familia de caballeros, sobrino de un Obispo de Pamplona, rompe en principio con el entorno familiar de búsqueda de ascenso social para dedicarse a la misión en Filipinas, llegando a ser procurador provincial de la Compañía en Filipinas ante la Corte de Madrid y Roma. Gran jurista, tiistoriador, geógrafo, poeta, político y orador. Por medio de documentos y obras del autor no sólo se desentraña la vida del jesuíta sino también su pensamiento frente a las Filipinas, la política o la religión.This article intends to contribute a series of coordinates to establish the life and thinking of Pedro Murillo Velarde y Bravo (Laujuar 1696-Puerto de Santa María 1753. Noble from a family of gentlemen and nephew of a Bishop of Pamplona, firstly breaks away from the family environment that seeks social promotion to dedicate himself to the mission in the Philippines, becoming the Society of Jesus'provincial representative in the Philippines before the Court of Madrid and Rome. Great jurist, historian, geographer, poet, politician and orator. Through the documents and works of the autor, not only is the life of the Jesuit unravelled but also his thinking on the Philippines politics and religión.

A dendrochronology based fire history of Jeffry pine-mixed conifer forests in the Sierra San Pedro Martir, Mexico

Science.gov (United States)

Scott L. Stephens; Carl N. Skinner; Samantha J. Gill

2003-01-01

Conifer forests in northwestern Mexico have not experienced systematic fire suppression or logging, making them unique in western North America. Fire regimes of Pinus jeffreyi Grev. & Balf. mixed conifer forests in the Sierra San Pedro Martir, Baja California, Mexico, were determined by identifying 105 fire dates from 1034 fire scars in 105 specimens. Fires were...

San Pedro de la Mata (Sonseca, Toledo. Building and decorating an early medieval stone church

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Mª de los Ángeles Utrero Agudo

2016-11-01

Full Text Available This work aims to offer those results obtained by means of the archaeological, stylistic and geological analysis of the church of San Pedro de La Mata, of its building and decorative materials and of its quarries. Combining these studies (and methodologies has made possible to identify the original form of the church, to pinpoint the origin of the materials and to characterize thus the skills of the workshops responsible for its construction and decoration.

Significantly improved surface morphology of N-polar GaN film grown on SiC substrate by the optimization of V/III ratio

Science.gov (United States)

Deng, Gaoqiang; Zhang, Yuantao; Yu, Ye; Yan, Long; Li, Pengchong; Han, Xu; Chen, Liang; Zhao, Degang; Du, Guotong

2018-04-01

In this paper, N-polar GaN films with different V/III ratios were grown on vicinal C-face SiC substrates by metalorganic chemical vapor deposition. During the growth of N-polar GaN film, the V/III ratio was controlled by adjusting the molar flow rate of ammonia while keeping the trimethylgallium flow rate unchanged. The influence of the V/III ratio on the surface morphology of N-polar GaN film has been studied. We find that the surface root mean square roughness of N-polar GaN film over an area of 20 × 20 μm2 can be reduced from 8.13 to 2.78 nm by optimization of the V/III ratio. Then, using the same growth conditions, N-polar InGaN/GaN multiple quantum wells (MQWs) light-emitting diodes (LEDs) were grown on the rough and the smooth N-polar GaN templates, respectively. Compared with the LED grown on the rough N-polar GaN template, dramatically improved interface sharpness and luminescence uniformity of the InGaN/GaN MQWs are achieved for the LED grown on the smooth N-polar GaN template.

The Cure Violence model: violence reduction in San Pedro Sula (Honduras

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Charles Ransford

2017-09-01

Full Text Available Developed in the United States, the Cure Violence model is a programme of epidemic control that reduces violence through changes to norms and behaviour. This article primarily examines the issue of violence in Honduras and, in particular, in San Pedro Sula which was for years the city with the highest homicide rates in the world. To tackle this situation, in 2013 an adapted version of the programme began to be implemented in certain areas of the city. After describing the adaptation of the model to the context of the Honduran city, its results are analysed in two periods of 2014 and 2015 (compared to 2013 and 2014, respectively: a significant reduction in shootings and a minor fall in the homicide figures stand out.

Pedro Poveda en clave historiográfica: un debate cultural y pedagógico del siglo XX

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Pego Puigbó, Armando

2007-12-01

Full Text Available In this paper a view on the historiographic reception of the life and works of the priest and pedagogue Pedro Poveda (1874-1936 is tried to offer. The characteristic features of his catholic pedagogical proposal are showed in the context of a secularized age. Poveda looked forward to making the Christian message present into the educational structures of the State through a dialogue between faith and science. This program for modernization implies the hermeneutic tools of a period marked by the activities of the ILE.En este artículo se procura ofrecer una panorámica de la recepción historiográfica de la vida y la obra del sacerdote y pedagogo Pedro Poveda (1874-1936. Se presentan así los rasgos de una singular propuesta pedagógica católica en una época secularizada. Poveda quiso hacer presente el mensaje cristiano en las estructuras educativas estatales animando el diálogo entre fe y ciencia. Este programa de modernización comprende también las claves hermenéuticas de una época marcada por las actividades de la ILE.

Subsídios para a gênese da imprensa musical brasileira e para a história do Hino da Independência, de Dom Pedro I Subsidies for the Brazilian musical press genesis and the history of the Independence Hymn, by Dom Pedro I

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Lino de Almeida Cardoso

2012-06-01

Full Text Available Este artigo tem por objetivos rever, mediante análise bibliográfica e de fontes primárias, a história de um de nossos símbolos musicais pátrios, o Hino da Independência, de Dom Pedro I, bem como trazer novos subsídios para o estudo da gênese da imprensa musical brasileira. Tem, igualmente, por escopo divulgar peculiaridades de uma antiga e pouco conhecida partitura desse hino, já não mais presentes em modernas edições de tal composição.This article aims at reviewing, through bibliographical and primary sources analysis, the history of one of Brazil´s national anthems, the Independence Hymn, by Dom Pedro I, as well as bringing new subsidies for the study of the Brazilian musical press origins. It also intends to reveal some peculiarities of an early and lesser known piano and voice score of the Hymn, not present in today's editions of this composition.

Synthesization of the Ar VIII 3s-3p beam-foil decay curve

International Nuclear Information System (INIS)

Lindgaard, A.; Veje, E.

1981-01-01

The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

Inorganic pigment study of the San Pedro Gonzalez Telmo Sibyls using total reflection X-ray fluorescence

International Nuclear Information System (INIS)

Vazquez, Cristina; Custo, Graciela; Barrio, Nestor; Burucua, Jose; Boeykens, Susana; Marte, Fernando

2010-01-01

This article describes the study carried out on a series of oil paintings on canvas from the eighteenth century that were restored at Centro de Produccion e Investigacion en Restauracion y Conservacion Artistica y Bibliografica - Tarea (CEIRCAB-Tarea), Buenos Aires, Argentina: the San Pedro Gonzalez Telmo Sibyls. Experimental study was undertaken to identify inorganic pigments and the technique used in their confection; and, in this way, try to add information about their local origin. Therefore special emphasis was put to infer technologies used in the manufacturing of these paintings. Elemental analysis was performed by total reflection X-ray fluorescence spectrometry (TXRF) and complemented by optical and polarized light microscopy. Microsampling was carefully done over areas of the paintings which were damaged and where a small additional loss will not be noticed. This investigation has shown that a variety of pigments were used, namely earth pigments (red and yellow ochres), white lead, vermilion, etc., and they were used either pure or in mixtures. This characterization helped conservators in their decisions regarding a better understanding of the deterioration processes. In addition, this research about the material composition allowed the art historians and restorers the possibility to obtain information about where, when or by whom The San Pedro Gonzalez Telmo Sibyls may have been painted.

Inorganic pigment study of the San Pedro Gonzalez Telmo Sibyls using total reflection X-ray fluorescence

Energy Technology Data Exchange (ETDEWEB)

Vazquez, Cristina, E-mail: vazquez@cnea.gov.a [Universidad de Buenos Aires, Facultad de Ingenieria, Paseo Colon 850. C1063ACU, Buenos Aires (Argentina); Comision Nacional de Energia Atomica, Gerencia Quimica, Av. Gral Paz 1499, B1650KNA, San Martin (Argentina); Custo, Graciela, E-mail: custo@cnea.gov.a [Comision Nacional de Energia Atomica, Gerencia Quimica, Av. Gral Paz 1499, B1650KNA, San Martin (Argentina); Barrio, Nestor, E-mail: nbarrio@unsam.edu.a [CEIRCAB-TAREA, Universidad Nacional de San Martin (UNSAM), Escuela de Humanidades, Campus Miguelete, 25 de Mayo y Francia, B1650KNA, San Martin (Argentina); Burucua, Jose, E-mail: gburucua@unsam.edu.a [CEIRCAB-TAREA, Universidad Nacional de San Martin (UNSAM), Escuela de Humanidades, Campus Miguelete, 25 de Mayo y Francia, B1650KNA, San Martin (Argentina); Boeykens, Susana [Universidad de Buenos Aires, Facultad de Ingenieria, Paseo Colon 850. C1063ACU, Buenos Aires (Argentina); Marte, Fernando, E-mail: fmarte@unsam.edu.a [CEIRCAB-TAREA, Universidad Nacional de San Martin (UNSAM), Escuela de Humanidades, Campus Miguelete, 25 de Mayo y Francia, B1650KNA, San Martin (Argentina)

2010-09-15

This article describes the study carried out on a series of oil paintings on canvas from the eighteenth century that were restored at Centro de Produccion e Investigacion en Restauracion y Conservacion Artistica y Bibliografica - Tarea (CEIRCAB-Tarea), Buenos Aires, Argentina: the San Pedro Gonzalez Telmo Sibyls. Experimental study was undertaken to identify inorganic pigments and the technique used in their confection; and, in this way, try to add information about their local origin. Therefore special emphasis was put to infer technologies used in the manufacturing of these paintings. Elemental analysis was performed by total reflection X-ray fluorescence spectrometry (TXRF) and complemented by optical and polarized light microscopy. Microsampling was carefully done over areas of the paintings which were damaged and where a small additional loss will not be noticed. This investigation has shown that a variety of pigments were used, namely earth pigments (red and yellow ochres), white lead, vermilion, etc., and they were used either pure or in mixtures. This characterization helped conservators in their decisions regarding a better understanding of the deterioration processes. In addition, this research about the material composition allowed the art historians and restorers the possibility to obtain information about where, when or by whom The San Pedro Gonzalez Telmo Sibyls may have been painted.

The geological setting of Santa Monica and San Pedro Basins, California Continental Borderland

Science.gov (United States)

Gorsline, D. S.

The California Continental Borderland's present configuration dates from about 4 to 5 × 10 6 years before present (BP) and is the most recent of several configuration of the southern California margin that have evolved after the North America plate over-rode the East Pacific Rise about 30 × 10 6 years ago. The present morphology is a series of two to three northwest-southeast trending rows of depressions separated by banks and insular ridges. Two inner basins, Santa Monica and San Pedro, have been the site for the California Basin Study (CaBs), funded by the US Department of Energy. The Santa Monica and San Pedro Basins contain post-Miocene sediment thicknesses of about 2.5 and 1.5 km respectively. During the Holocene (past 10,000 years) about 10-12m have accumulated. The sediment entered the basin by one or a combination of processes including particle infall (mainly as bioaggregates) from surface waters, from nepheloid plumes (surface, mid-depth and near-bottom), from turbidity currents, mass movements, and to a very minor degree direct precipitation. In Santa Monica Basin, during the last century, particle infall nepheloid plume transport have been the most common processes. The former process has been dominant in thecentral basin at water depths from 900-945m, where characteristic silt-clay is found with a typical mean particle diameter of about 0.0006mm ( φ standard deviation = 2; φ skewness near zero). Kurtosis is typically 2 (platykurtic); these values indicate broad, near-log normal particle size distributions. The calcium carbonate content averages about 10% and organic carbon about 4%. Surficial sediment bulk densities are 1.1-1.2 and accumulation rates range from 16-30mg cm -2Yr 1 in this central fine deposit. Bottom water oxygen contents are at or below 0.1 ml 1 -1 so that bioturbation is inhibited, thus preserving the primary sedimentary stratification. There appear to be annual varves, but the laminae couplets are not simple wet-dry season pairs

Solidarity According to the Thought of Fr. Pedro Arrupe and Its Application to Jesuit Higher Education Today

Science.gov (United States)

Menkhaus, James

2013-01-01

Fr. Pedro Arrupe, S.J. was elected the 28th superior general of the Society of Jesus in 1965 and served in that role until 1983. As superior general, Arrupe sought to shape the Jesuits in the spirit of the vision of Vatican II, as well as the original charism of the founder of the Jesuit, St. Ignatius. The questions this dissertation seeks to…

Heavy metals in water of the San Pedro River in Chihuahua, Mexico and its potential health risk

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Melida Gutierrez

2008-06-01

Full Text Available The objective of this study was to determine the seasonal and downstream water quality variations of the San Pedro River in Chihuahua, Mexico. Water samples were collected monthly from October 2005 to August 2006 in triplicate, totaling 165 water samples. The five sampling locations were: below the Francisco I. Madero dam (LP; between Rosales and Delicias (RD; Meoqui (M; El Torreon (ET, and Julimes (LJ. The levels of As, Be, Ca, Cd, Co, Cu, Cr, Fe, Li, Mg, Mn, Mo, Ni, Pb, Sb, Se, Sr, Ti, Ta, V and Zn were measured using an Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES Perkin Elmer 2100. In addition, temperature, pH, electrical conductivity and total and fecal coliformes were determined. The statistical analysis considered a factorial treatment design; where factor A was the location point and factor B was sampling date. In addition, a multivariate technique looking for principal components was performed. The results indicated that some samples exceeded Mexican standards for As, Be, Ca, Cd, Co, Cr, Fe, Mn, Ni, Pb, Sb, Se, Sr and Zn. The As level must be considered for a red flag to the communities along the Rio San Pedro because both the monthly average level (0.10 mg L-1 and location (0.10 mg L-1 exceeded the Mexican and International norms. The multivariate analysis showed a predominant aggregation at the LP location, meaning that there was a predominance of As, Sr, Fe and Li. At the rest of the locations the elements did not present a tendency for aggregation. Statistics applied to sampling month showed that December, January, March and April were aggregated in a negative quadrant of component 1 indicating a predominance of V, Ni, Be, Fe and As. Overall, the results confirmed that this stretch of the San Pedro River is contaminated with heavy metals and other contaminants that might affect human health as well as the health of the ecosystem.

Heavy metals in water of the San Pedro River in Chihuahua, Mexico and its potential health risk

Science.gov (United States)

Gutiérrez, Roberto L.; Rubio-Arias, Hector; Quintana, Ray; Ortega, Juan Angel; Gutierrez, Melida

2008-01-01

The objective of this study was to determine the seasonal and downstream water quality variations of the San Pedro River in Chihuahua, Mexico. Water samples were collected monthly from October 2005 to August 2006 in triplicate, totaling 165 water samples. The five sampling locations were: below the Francisco I. Madero dam (LP); between Rosales and Delicias (RD); Meoqui (M); El Torreon (ET), and Julimes (LJ). The levels of As, Be, Ca, Cd, Co, Cu, Cr, Fe, Li, Mg, Mn, Mo, Ni, Pb, Sb, Se, Sr, Ti, Ta, V and Zn were measured using an Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) Perkin Elmer 2100. In addition, temperature, pH, electrical conductivity and total and fecal coliformes were determined. The statistical analysis considered a factorial treatment design; where factor A was the location point and factor B was sampling date. In addition, a multivariate technique looking for principal components was performed. The results indicated that some samples exceeded Mexican standards for As, Be, Ca, Cd, Co, Cr, Fe, Mn, Ni, Pb, Sb, Se, Sr and Zn. The As level must be considered for a red flag to the communities along the Rio San Pedro because both the monthly average level (0.10 mg L−1) and location (0.10 mg L−1) exceeded the Mexican and International norms. The multivariate analysis showed a predominant aggregation at the LP location, meaning that there was a predominance of As, Sr, Fe and Li. At the rest of the locations the elements did not present a tendency for aggregation. Statistics applied to sampling month showed that December, January, March and April were aggregated in a negative quadrant of component 1 indicating a predominance of V, Ni, Be, Fe and As. Overall, the results confirmed that this stretch of the San Pedro River is contaminated with heavy metals and other contaminants that might affect human health as well as the health of the ecosystem. PMID:18678922

Ecosystem services valuation to support decisionmaking on public lands—A case study of the San Pedro River watershed, Arizona

Science.gov (United States)

Bagstad, Kenneth J.; Semmens, Darius; Winthrop, Rob; Jaworksi, Delilah; Larson, Joel

2012-01-01

This report details the findings of the Bureau of Land Management–U.S. Geological Survey Ecosystem Services Valuation Pilot Study. This project evaluated alternative methods and tools that quantify and value ecosystem services, and it assessed the tools’ readiness for use in the Bureau of Land Management decisionmaking process. We tested these tools on the San Pedro River watershed in northern Sonora, Mexico, and southeast Arizona. The study area includes the San Pedro Riparian National Conservation Area (managed by the Bureau of Land Management), which has been a focal point for conservation activities and scientific research in recent decades. We applied past site-specific primary valuation studies, value transfer, the Wildlife Habitat Benefits Estimation Toolkit, and the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) and Artificial Intelligence for Ecosystem Services (ARIES) models to value locally important ecosystem services for the San Pedro River watershed—water, carbon, biodiversity, and cultural values. We tested these approaches on a series of scenarios to evaluate ecosystem service changes and the ability of the tools to accommodate scenarios. A suite of additional tools were either at too early a stage of development to run, were proprietary, or were place-specific tools inappropriate for application to the San Pedro River watershed. We described the strengths and weaknesses of these additional ecosystem service tools against a series of evaluative criteria related to their usefulness for Bureau of Land Management decisionmaking. Using these tools, we quantified gains or losses of ecosystem services under three categories of scenarios: urban growth, mesquite management, and water augmentation. These results quantify tradeoffs and could be useful for decisionmaking within Bureau of Land Management district or field offices. Results are accompanied by a relatively high level of uncertainty associated with model outputs, valuation

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

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Gouri Shankar Pandey

2013-01-01

Full Text Available Flow cytometry is widely used in cancer research for diagnosis, detection of minimal residual disease, as well as immune monitoring and profiling following immunotherapy. Detection of specific host proteins for diagnosis predominantly uses quantitative PCR and western blotting assays. In this study, we optimized a flow cytometry-based detection assay for Factor VIII protein in peripheral blood mononuclear cells (PBMCs. An indirect intracellular staining (ICS method was standardized using monoclonal antibodies to different domains of human Factor VIII protein. The FVIII protein expression level was estimated by calculating the mean and median fluorescence intensities (MFI values for each monoclonal antibody. ICS staining of transiently transfected cell lines supported the method's specificity. Intracellular FVIII protein expression was also detected by the monoclonal antibodies used in the study in PBMCs of five blood donors. In summary, our data suggest that intracellular FVIII detection in PBMCs of hemophilia A patients can be a rapid and reliable method to detect intracellular FVIII levels.

Evaluación de la contaminación por metales en pasivos ambientales de actividades metalúrgicas históricas en el distrito minero Cerro de San Pedro, S.L.P. (México)

OpenAIRE

Rodríguez y Rodríguez, Yolanda

2011-01-01

Pasivos ambientales minero-metalúrgicos son frecuentemente encontrados en regiones donde estas actividades se han desarrollado históricamente, como es el caso del Estado de San Luis Potosí, en donde desde el siglo XVI han existido importantes centros mineros, destacando entre ellos el Distrito Minero de Cerro de San Pedro que se localiza en la porción centro-sur del Estado, 19.5 kilómetros al NW de la ciudad de San Luis Potosí. La situación geográfica del sitio donde se descubriero...

Assessing hydrologic impacts of future Land Change scenarios in the San Pedro River (U.S./Mexico)

Science.gov (United States)

Kepner, W. G.; Burns, S.; Sidman, G.; Levick, L.; Goodrich, D. C.; Guertin, P.; Yee, W.; Scianni, M.

2012-12-01

An approach was developed to characterize the hydrologic impacts of urban expansion through time for the San Pedro River, a watershed of immense international importance that straddles the U.S./Mexico border. Future urban growth is a key driving force altering local and regional hydrology and is represented by decadal changes in housing density maps from 2010 to 2100 derived from the Integrated Climate and Land-Use Scenarios (ICLUS) database. ICLUS developed future housing density maps by adapting the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) social, economic, and demographic storylines to the conterminous United States. To characterize the hydrologic impacts of future growth, the housing density maps were reclassified to National Land Cover Database 2006 land cover classes and used to parameterize the Soil and Water Assessment Tool (SWAT) using the Automated Geospatial Watershed Assessment (AGWA) tool. The presentation will report 1) the methodology for adapting the ICLUS data for use in AGWA as an approach to evaluate basin-wide impacts of development on water-quantity and -quality, 2) initial results of the application of the methodology, and 3) discuss implications of the analysis.

Analysis of factor VIII gene inversions in 164 unrelated hemophilia A families

Energy Technology Data Exchange (ETDEWEB)

Vnencak-Jones, L.; Phillips, J.A. III; Janco, R.L. [Vanderbilt Univ. School of Medicine, Nashville, TN (United States)] [and others

1994-09-01

Hemophilia A is an X-linked recessive disease with variable phenotype and both heterogeneous and wide spread mutations in the factor VIII (F8) gene. As a result, diagnostic carrier or prenatal testing often relies upon laborious DNA linkage analysis. Recently, inversion mutations resulting from an intrachromosomal recombination between DNA sequences in one of two A genes {approximately}500 kb upstream from the F8 gene and a homologous A gene in intron 22 of the F8 gene were identified and found in 45% of severe hemophiliacs. We have analyzed banked DNA collected since 1986 from affected males or obligate carrier females representing 164 unrelated hemophilia A families. The disease was sporadic in 37%, familial in 54% and in 10% of families incomplete information was given. A unique deletion was identified in 1/164, a normal pattern was observed in 110/164 (67%), and 53/164 (32%) families had inversion mutations with 43/53 (81%) involving the distal A gene (R3 pattern) and 10/53 (19%) involving the proximal A gene (R2 pattern). While 19% of all rearrangements were R2, in 35 families with severe disease (< 1% VIII:C activity) all 16 rearrangements seen were R3. In 18 families with the R3 pattern and known activities, 16 (89%) had levels < 1%, with the remaining 2 families having {le} 2.4% activity. Further, 18 referrals specifically noted the production of inhibitors and 8/18 (45%) had the R3 pattern. Our findings demonstrate that the R3 inversion mutation patterns is (1) only seen with VIII:C activity levels of {le} 2.4%, (2) seen in 46% of families with severe hemophilia, (3) seen in 45% of hemophiliacs known to have inhibitors, (4) not correlated with sporadic or familial disease and (5) not in disequilibrium with the Bcl I or Taq I intron 18 or ST14 polymorphisms. Finally, in families positive for an inversion mutation, direct testing offers a highly accurate and less expensive alternative to DNA linkage analysis.

AN ACCURACY ASSESSMENT OF 1997 LANDSAT THEMATIC MAPPER DERIVED LAND COVER FOR THE UPPER SAN PEDRO WATERSHED (U.S./MEXICO)

Science.gov (United States)

High-Resolution airborne color video data were used to evaluate the accuracy of a land cover map of the upper San Pedro River watershed, derived from June 1997 Landsat Thematic Mapper data. The land cover map was interpreted and generated by Instituto del Medio Ambiente y el Bes...

Study of plaster finishes on San Pedro de los Francos church at Calatayud

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Sánchez de Rojas, Mª I

2007-06-01

Full Text Available This study of the plaster finishes on San Pedro de los Francos Church at Calatayud revealed, firstly, the stratigraphic sequence based on the interpretation of the bonding interfaces; and secondly, the evolution of placement techniques from mudéjar style textured and painted false stonework (15th century to the smooth plastering and paint typical of later phases. Finally, scanning electron microscope (SEM, energy dispersive X-ray microanalysis (EDX and X-ray diffraction (XRD studies showed that gypsum and anhydrite are the main components of both binder and aggregate in these mortars. In other words, they constitute traditional multiphase plasters whose coarser particles or aggregate were a byproduct of the artisanal manufacturing process.El estudio de los enlucidos de la iglesia de San Pedro de los Francos de Calatayud ha permitido demostrar, en primer lugar, la secuencia estratigráfica mediante la lectura de la interfase de adherencia; en segundo lugar, la evolución de las técnicas de aplicación, desde el enlucido mudéjar, un fingido de piedra agramilado y pintado (siglo XV, hasta los enlucidos lisos y pinturas aplicados posteriormente. Y, finalmente, a través de los estudios de microscopía electrónica de barrido (SEM, microanálisis por energía dispersiva de rayos X (EDX y de difracción de rayos X (DRX, se ha determinado que son morteros en los que tanto el conglomerante como el árido son yeso y anhidrita, que correspondería a un yeso tradicional multifase, cuyos granos más gruesos analizados como áridos proceden del producto obtenido artesanalmente.

Gravity data from the San Pedro River Basin, Cochise County, Arizona

Science.gov (United States)

Kennedy, Jeffrey R.; Winester, Daniel

2011-01-01

The U.S. Geological Survey, Arizona Water Science Center in cooperation with the National Oceanic and Atmospheric Administration, National Geodetic Survey has collected relative and absolute gravity data at 321 stations in the San Pedro River Basin of southeastern Arizona since 2000. Data are of three types: observed gravity values and associated free-air, simple Bouguer, and complete Bouguer anomaly values, useful for subsurface-density modeling; high-precision relative-gravity surveys repeated over time, useful for aquifer-storage-change monitoring; and absolute-gravity values, useful as base stations for relative-gravity surveys and for monitoring gravity change over time. The data are compiled, without interpretation, in three spreadsheet files. Gravity values, GPS locations, and driving directions for absolute-gravity base stations are presented as National Geodetic Survey site descriptions.

El Duque de San Pedro de Galatino y la azucarera de Láchar

OpenAIRE

Francisco José Sánchez Sánchez

2015-01-01

El objetivo del trabajo ha sido el estudio de la fábrica azucarera, construida en el año 1890 en la localidad de Láchar (Granada), denominada “Fábrica Conde de Benalúa”, propiedad de Julio Quesada Cañaveral y Piédrola, Señor de Láchar, Conde de Benalúa y de lasVillas, Duque de San Pedro de Galatino y Grande de España. La metodología ha sido posible gracias a la búsqueda de la documentación en los archivos públicos, nacionales, provinciales, locales y privados. Las conclusiones que presentamos...

Influence Model Assisted Learning Cycle Mind Map to Achievement Physics Laboratory Judging from the performance Grade VIII SMPN 1 Rejoso Pasuruan

OpenAIRE

Ary Analisa Rahma

2014-01-01

Pengaruh Model Siklus Belajar Berbantuan Mind Map terhadap Prestasi Belajar Fisika Ditinjau dari Kinerja Laboratorium Siswa Kelas VIII SMPN 1 Rejoso Kabupaten Pasuruan Abstract: This study aimed to examine the effect of the learning cycle models aided the mind map on the learning achievement in terms of the performance of laboratory physics class VIII student on light material in SMP Negeri 1 Rejoso Pasuruan. This study is a quasi-experimental research. The research design used is a 2 x 2...

Subjects and ideas of a lost work: the Spongia (1617 by Pedro de Torres Rámila

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Xavier Tubau

2010-12-01

Full Text Available The literary controversy between Lope de Vega and Pedro de Torres Rámila has not been addressed since the publication of Joaquin de Entrambasaguas’s pioneering study on the subject. The original Spongia (1617 went missing, and we only have the excerpts of the book reproduced by the authors of Expostulatio Spongiae (1618. The aim of this article is to rebuild Torres Ramila’s basic ideas on literary theory from the contents of such excerpts.

Saberes e práticas termais: uma perspectiva comparada em Portugal (Termas de S. Pedro do Sul e no Brasil (Caldas da Imperatriz Thermal knowledge and therapies: a comparative view of Portugal (São Pedro do Sul hot springs and Brazil (Caldas da Imperatriz hot springs

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Maria Manuel Quintela

2004-01-01

Full Text Available Pretende-se neste artigo discutir como o termalismo, como prática terapêutica, se constituiu como um saber dito 'científico' legitimado pela medicina, que criou estabelecimentos terapêuticos e estâncias termais. Tomaremos como fontes textos dos séculos XIX e XX. A pesquisa foi iniciada em Portugal, em 1996, sendo efetuada uma etnografia das experiências termais nas Termas de S. Pedro do Sul. No Brasil, a pesquisa nas Caldas da Imperatriz foi iniciada em agosto de 2001 e encontra-se ainda em curso.Based on nineteenth- and twentieth-century texts, the article discusses how medicine legitimized the therapeutic practice of thermalism as so-called 'scientific' knowledge, with the creation of therapeutic establishments and hot-springs resorts. My research began in Portugal in 1996, where I produced an ethnography of experiences at the São Pedro do Sul hot springs. My research at Brazil's Caldas da Imperatriz, initiated in August 2001, is still underway.

Efeitos de humor no poema VIII de Catulo

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Paulo Sérgio Vasconcellos

1997-12-01

Full Text Available Neste artigo apresenta-se uma contribuição ao estudo dos efeitos de humor no poema VIII de Catulo; de fato, além do metro dessa composição e de outros elementos criadores de distanciamento irônico que os estudiosos têm apontado, um outro aspecto de sua forma, ainda pouco percebido, guia a leitura para essa interpretação: o jogo, a maneira de anagrama imperfeito (o “hipograma”, ou, mais precisamente, “criptograma”, de Saussure, com os sons do nome da amada, aparentemente calado. E mais uma das maneiras com que o poeta elabora a jocosa diferença entre o que se diz e o que, sentido e reprimido, deixa-se, porém, transparecer.

Cerebro y metáfora en la novela "Pedro Páramo", de Juan Rulfo

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CECILIA EDILMA DÍAZ DÍAZ

2010-01-01

Full Text Available Se trata de un avance de investigación que aplica la teoría neurolingüística de Omar Parra Rozo para leer y comprender la metáfora en un texto literario. Se toma como objeto de estudio la novela "Pedro Páramo" de Juan Rulfo, específicamente los fragmentos que hablan acerca de la imagen compleja (religión-poder y muerte. El ejercicio de investigación alcanzó a establecer la relación que existe entre imagen- cerebro y metáfora, en el discurso de esta novela.

The Presidents’ Tales. Storytelling and Biographical Stories in the Case of Pedro Pablo Kuczynski

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Mathias Mackelmann

2017-12-01

Full Text Available The following article analyzes the use of storytelling and biographical stories as elements of communication by presidential governments in Peru. It emphasizes Pedro Pablo Kuczynski administration. It briefly refers to the storytelling techniques used during the campaign that led to his election and then focuses mainly on the storytelling process during his current administration. The different strategies used are discussed in detail, analyzing whether they represent a successful formula to communicate with citizens and maintain a good government image. Finally, the article addresses external political factors that could radically change the population’s perception.

Spectra of the W VIII isoelectronic sequence: III. Re IX

International Nuclear Information System (INIS)

Ryabtsev, A N; Kononov, E Ya; Kildiyarova, R R; Tchang-Brillet, W-Ü L; Wyart, J-F; Champion, N; Blaess, C

2015-01-01

Rhenium spectra excited in vacuum spark sources of different setups and electric circuits were recorded on two high resolution vacuum spectrographs: a 10 m normal incidence spectrograph with a 3600 l mm −1 grating in the Meudon Observatory and a 3 m grazing incidence spectrograph with a 3600 l mm −1 grating in the Institute of Spectroscopy in Troitsk. A total of 112 lines in the region 146–244 Å were identified as transitions from the interacting excited even configurations 4f 12 5s 2 5p 6 5d + 4f 13 5s 2 5p 5 (5d + 6s) + 4f 14 5s 2 5p 4 (5d + 6s) to the low-lying odd configurations 4f 13 5s 2 5p 6 and 4f 14 5s 2 5p 5 . A change of the ground configuration from 4f 13 5s 2 5p 6 to 4f 14 5s 2 5p 5 in a comparison with the previous spectra of the isoelectronic sequence Hf VI–W VIII was observed. Fine structure splittings and relative positions of the odd terms were established, and 83 levels of the excited even configurations were found. (paper)

También la interpretación es un collage: conjeturas en torno a Pedro Manrique Figueroa

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Jerónimo Duarte Riascos

2010-06-01

Full Text Available Pedro Manrique Figueroa es un personaje central en la historia del arte colombiano. De su vida y obra no quedan más que huellas, y es quizás por esta razón que su existencia se encuentra a medio camino entra la realidad y la ficción. Este texto, tras realizar un recuento de la génesis del personaje, pretende contribuir al análisis sobre Manrique desde dos puntos de vista diferentes. El primero tratará de aproximarse al gesto de su creación desde la noción de autor de Foucault y las particularidades del juego según Huizinga y Caillois. El segundo hará lo propio con el personaje para analizar su performancia.Pedro Manrique Figueroa is a pivotal figure in Colombian art history. All that is left from his life and work are memories, perhaps that is the reason why his existence swirls around reality and fiction. This article, after briefly describing the character’s genesis, aims to analyze Manrique from two different points of view. The first one will try to examine the act of creation with the tools provided by the theories of Foucault, Huizinga and Caillois. The second one, will approach the character to study its performative qualities.

Quantifying and valuing ecosystem services: An application of ARIES to the San Pedro River basin, USA

Science.gov (United States)

Bagstad, Kenneth J.; Semmens, Darius J.; Villa, Ferdinando; Johnson, Gary

2014-01-01

A large body of research exists that identifies and values ecosystem services - the benefits that ecosystems provide to humans (MA, 2005) - and their underlying ecological processes. However, the development of software decision support tools that integrate ecology, economics and geography that can be independently used within the public, private, academic and NGO sectors is a more recent phenomenon (Ruhl et al., 2007; Daily et al., 2009). Spurred by growing demand for more sophisticated analysis of the social and economic consequences of land management decisions, the US Department of Interior - Bureau of Land Management (BLM) launched a pilot project with the US Geological Survey (USGS) to assess the usefulness and feasibility of ecosystem service assessment and valuation tools to provide inputs to decision-making. The project analysed ecosystem services in the US portion of the San Pedro River watershed, which includes the BLM-managed San Pedro Riparian National Conservation Area (SPRNCA), to improve the understanding of complex social and ecological relationships that transcend administrative divisions. The BLM manages some 99 million hectares, primarily in the western United States, and 283 million hectares of sub-surface mineral estate. BLM's multiple-use mission requires that it appropriately balance non-extractive uses such as habitat conservation, recreation and archaeological heritage protection and the extractive use of resources such as timber, oil and gas, coal, uranium, and other minerals.

La identidad religiosa en el humanismo bíblico español: Pedro de Valencia y la integración judía e islámica

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Nieto Ibáñez, Jesús M.ª

2015-06-01

Full Text Available The work of the humanist Pedro de Valencia belongs to “biblical humanism”. Religion and politics are inseparable in the work of this author. In the sixteenth century, a part of the population in Spain still subscribed to Jewish or Islamic thought. The Spanish church was making a huge effort at the time to integrate within the traditional Catholicism converts from these two communities. In this conflict the justifications of religious identity in various writings of Pedro de Valencia can be located. The common denominator of the writings discussed is summarized in the idea of religious unity of Conversos and Moriscos under the authority of the king in response to the conflicts in the Spain of the time.La obra del humanista Pedro de Valencia pertenece al «humanismo biblista». Religión y política son inseparables en este autor. En la España del siglo XVI existía todavía una parte de la población que pensaba en clave judía o bien en clave islámica. La iglesia española del momento estaba haciendo un esfuerzo enorme por integrar dentro del catolicismo tradicional a los conversos de estas dos comunidades. En este conflicto se enmarcan las justificaciones de la identidad religiosa en varios escritos de Pedro de Valencia. El común denominador de los escritos comentados se resume en la idea de la unidad religiosa de judeoconversos y moriscos bajo la autoridad del rey como respuesta a los conflictos de la España de la época.

Las hermanas de los pobres de San Pedro Claver

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Rafael Méndez Buendía

1982-01-01

Full Text Available "El ser humano actúa, siente y se desenvuelve siempre de acuerdo con lo que él imagina ser verdad acerca de sí mismo y del ambiente que le rodea". Esta es la ley básica del pensamiento humano y este es el modo de que estamos hechos ya que la imaginación desempeña en nuestras vidas un papel mucho más importante de lo que nos podemos imaginar. Extraña al parecer la manera de iniciar este ensayo monográfico de una ilustre congregación religiosa que nace en Barranquilla, "la puerta de oro de Colombia" y "la sultana de los pies desnudos", allá por febrero de 1912, bajo el título de "Hermanas de los Pobres de San Pedro Claver", nombre sugerido a la fundadora por el obispo de Cartagena, monseñor Brioschi, para honrar en forma tal, según sus palabras, al "modelo de virtudes religiosas y al gran apóstol de la caridad cristiana".

Cuerpo, enfermedad y ciudadanía en las crónicas urbanas de Pedro Lemebel

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Andrea Ostrov

2011-12-01

Full Text Available The chronicles by Pedro Lemebel configure a cartography of the suburbs of Santiago. It lights up those areas excluded from the “official” map of the city. In the case of Loco afán. Crónicas de sidario, the narrator runs through transvesti, prostitution and AIDS, linking gender and sexuality with other variables, such as ethinicity, language and social status, all involved in the construction of a Latinamerican homossexual subjectivity, which is pictured in these texts as an instance of resistance, towards the dominant identity models.

Staining for factor VIII related antigen and Ulex europaeus agglutinin I (UEA-I) in 230 tumours. An assessment of their specificity for angiosarcoma and Kaposi's sarcoma.

Science.gov (United States)

Leader, M; Collins, M; Patel, J; Henry, K

1986-11-01

In this study we examined the staining reactivity of commercially available antisera to factor VIII related antigen (F VIII RAg) and Ulex europaeus agglutinin I (UEA-I) on sections from 230 formalin fixed paraffin embedded tumours. These included 196 sarcomas, 20 carcinomas and 14 angiomas. All angiomas showed positive staining for F VIII RAg; all carcinomas showed negative staining; the vasoformative areas of all angiosarcomas stained positively but only four of six angiosarcomas showed positive staining of their solid areas; of seven Kaposi's sarcomas, all showed positive staining of vessels and six showed positive staining of the spindle cell component. In the remaining 181 non-vascular sarcomas there was a false positive result in four tumours (2.2%), three of which had a history of irradiation. Pre-radiotherapy biopsies of these three tumours stained negatively with anti-F VIII RAg. UEA-I was demonstrated in all the angiomas studied, in all angiosarcomas (including the solid components) and in well-formed vessels of all Kaposi's sarcomas, but only in the spindle cell component of 3/6. However, there was an unacceptably high rate of false positive staining amongst the carcinomas and non-vascular sarcomas. In conclusion, F VIII RAg is a specific but not a sensitive marker of angiosarcomas; UEA-I is a sensitive but not a specific marker of angiosarcomas.

Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex.

Science.gov (United States)

Alonso, Fernando; Kassem, Mohammad W; Iwanaga, Joe; Oskouian, Rod J; Loukas, Marios; Demerdash, Amin; Tubbs, R Shane

2017-08-16

Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms. The anterior inferior cerebellar artery (AICA) has variable branches producing vascular loops that can compress the facial cranial nerve (CN) VII and vestibulocochlear (CN VIII) nerves. AICA compression of the facial-vestibulocochlear nerve complex can lead to various clinical presentations, including hemifacial spasm (HFS), tinnitus, and hemiataxia. The formation of arterial loops inside or outside of the internal auditory meatus (IAM) can cause abutment or compression of CN VII and CN VIII. Twenty-five (50 sides) fresh adult cadavers underwent dissection of the cerebellopontine angle in the supine position. In regard to relationships between the AICA and the nerves of the facial/vestibulocochlear complex, 33 arteries (66%) traveled in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Five arteries (10%) traveled below the CN VII/VIII complex, six (12%) traveled posterior to the nerve complex, four (8%) formed a semi-circle around the upper half of the nerve complex, and two (4%) traveled between and partially separated the nervus intermedius and facial nerve proper. Our study found that the majority of AICA will travel in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Although the relationship between the AICA and porus acusticus and AICA and the nerves of the CN VII/VIII complex are variable, based on our findings, some themes exist. Surgeons should consider these with approaches to the cerebellopontine angle.

Pedro Duque arrives at KSC for the STS-95 launch

Science.gov (United States)

1998-01-01

STS-95 Mission Specialist Pedro Duque, with the European Space Agency (ESA), arrives at Kennedy Space Center's Shuttle Landing Facility aboard a T-38 jet as part of final preparations for launch. The STS-95 mission, targeted for liftoff at 2 p.m. on Oct. 29, includes research payloads such as the Spartan solar- observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process. The mission is expected to last 8 days, 21 hours and 49 minutes, and return to KSC on Nov. 7. The other STS-95 crew members are Mission Commander Curtis L. Brown Jr., Pilot Steven W. Lindsey, Mission Specialist Scott E. Parazynski, Mission Specialist Stephen K. Robinson, Payload Specialist John H. Glenn Jr., senator from Ohio, and Payload Specialist Chiaki Mukai, with the National Space Development Agency of Japan (NASDA).

In vivo recovery and safety of human factor VIII product AAFACT in patients with haemophilia A

NARCIS (Netherlands)

Vossebeld, P. J. M.; Tissing, M. H.; van den Berg, H. M.; Leebeek, F. W. G.; de Goede-Bolder, A.; Novakova, I. R. O.; Gerrits, W. B. J.; Peters, M.; Koopman, M. M. W.; Faber, A.; Hiemstra, H.; Grob, P.; Strengers, P. F. W.

2003-01-01

AAFACT, a monoclonal purified, solvent/detergent treated human plasma-derived coagulation factor VIII concentrate obtained from plasma of voluntary, non-remunerated blood donors, is manufactured and marketed in the Netherlands by Sanquin Plasma Products since 1995. In a postmarketing surveillance

Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A

Science.gov (United States)

Sherman, Alexandra; Biswas, Moanaro; Herzog, Roland W.

2017-01-01

Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein formulations available, the risk of developing anti-dug antibodies (“inhibitors”) remains. Overall, 20–30% of patients with severe disease develop inhibitors. Current clinical immune tolerance induction protocols to eliminate inhibitors are not effective in all patients, and there are no prophylactic protocols to prevent the immune response. New experimental therapies, such as gene and cell therapies, show promising results in pre-clinical studies in animal models of hemophilia. Examples include hepatic gene transfer with viral vectors, genetically engineered regulatory T cells (Treg), in vivo Treg induction using immune modulatory drugs, and maternal antigen transfer. Furthermore, an oral tolerance protocol is being developed based on transgenic lettuce plants, which suppressed inhibitor formation in hemophilic mice and dogs. Hopefully, some of these innovative approaches will reduce the risk of and/or more effectively eliminate inhibitor formation in future treatment of hemophilia A. PMID:29225598

San Pedro Martir Telescope: Mexican design endeavor

Science.gov (United States)

Toledo-Ramirez, Gengis K.; Bringas-Rico, Vicente; Reyes, Noe; Uribe, Jorge; Lopez, Aldo; Tovar, Carlos; Caballero, Xochitl; Del-Llano, Luis; Martinez, Cesar; Macias, Eduardo; Lee, William; Carramiñana, Alberto; Richer, Michael; González, Jesús; Sanchez, Beatriz; Lucero, Diana; Manuel, Rogelio; Segura, Jose; Rubio, Saul; Gonzalez, German; Hernandez, Obed; García, Mary; Lazaro, Jose; Rosales-Ortega, Fabian; Herrera, Joel; Sierra, Gerardo; Serrano, Hazael

2016-08-01

The Telescopio San Pedro Martir (TSPM) is a new ground-based optical telescope project, with a 6.5 meters honeycomb primary mirror, to be built in the Observatorio Astronomico Nacional on the Sierra San Pedro Martir (OAN-SPM) located in Baja California, Mexico. The OAN-SPM has an altitude of 2830 meters above sea level; it is among the best location for astronomical observation in the world. It is located 1830 m higher than the atmospheric inversion layer with 70% of photometric nights, 80% of spectroscopic nights and a sky brightness up to 22 mag/arcsec2. The TSPM will be suitable for general science projects intended to improve the knowledge of the universe established on the Official Mexican Program for Science, Technology and Innovation 2014-2018. The telescope efforts are headed by two Mexican institutions in name of the Mexican astronomical community: the Universidad Nacional Autonoma de Mexico and the Instituto Nacional de Astrofisica, Optica y Electronica. The telescope has been financially supported mainly by the Consejo Nacional de Ciencia y Tecnologia (CONACYT). It is under development by Mexican scientists and engineers from the Center for Engineering and Industrial Development. This development is supported by a Mexican-American scientific cooperation, through a partnership with the University of Arizona (UA), and the Smithsonian Astrophysical Observatory (SAO). M3 Engineering and Technology Corporation in charge of enclosure and building design. The TSPM will be designed to allow flexibility and possible upgrades in order to maximize resources. Its optical and mechanical designs are based upon those of the Magellan and MMT telescopes. The TSPM primary mirror and its cell will be provided by the INAOE and UA. The telescope will be optimized from the near ultraviolet to the near infrared wavelength range (0.35-2.5 m), but will allow observations up to 26μm. The TSPM will initially offer a f/5 Cassegrain focal station. Later, four folded Cassegrain and

Mission Specialist Pedro Duque smiles at camera while at Launch Pad 39B

Science.gov (United States)

1998-01-01

STS-95 Mission Specialist Pedro Duque of Spain, with the European Space Agency (ESA), smiles for the camera from Launch Pad 39B. The STS-95 crew were making final preparations for launch, targeted for liftoff at 2 p.m. on Oct. 29. Other crew members not shown are Mission Commander Curtis L. Brown Jr., Pilot Steven W. Lindsey, Mission Specialists Scott E. Parazynski, Stephen K. Robinsion, and and Payload Specialists John H. Glenn Jr., senator from Ohio, and Chiaki Mukai, with the National Space Development Agency of Japan (NASDA). The STS-95 mission is expected to last 8 days, 21 hours and 49 minutes, returning to KSC at 11:49 a.m. EST on Nov. 7.

PENGARUH PENGUASAAN KONSEP TEOREMA PYTHAGORAS TERHADAP KEMAMPUAN MENYELESAIKAN SOAL-SOAL BANGUN RUANG SISI DATAR PADA SISWA KELAS VIII MTS NEGERI BALANG-BALANG

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Syahrida Zaerani

2017-12-01

Abstract: This study aims to determine the impact of the mastery of Pythagoras Theorem concepts on the ability of MTs Negeri Balang-Balang grade VIII students to solve polyhedron problems. This study is a quantitative research with ex post facto design. Statistical population consists of all grade VIII students in MTs Negeri Balang-Balang which was 204 students. The number of sampling used is 102 respondents taken by simple random sampling technique. The research instrument was a test related to Pythagorean an polyhedron problems. Descriptive and inferential statistics were performed as the statistical analysis. The descriptive analysis result shows that the mastery of Pythagoras Theorem concepts is within the category of ‘high’ and the ability of solving polyhedron problems is as well. The inferential statistical analysis using simple linear regression shows that there is an impact of the mastery of Pythagoras Theorem concepts on polyhedron problem solving ability of Grade VIII students of MTs Negeri Balang-Balang.

Internal motions in H II regions. XI. The emission nebula sharpless 206

International Nuclear Information System (INIS)

Pismis, P.; Hasse, I.

1982-01-01

Radial velocities at 142 points are obtained on the H II region S206 by photographic Fabry-Perot interferometry using the reflectors with apertures of 2.1 meters at San Pedro Martir and 1 m at Tonantzintla. The overall velocity agrees with previous determinations. Our velocities cover the western faint extensions of the nebula not studied hitherto. The velocity field is consistent with a directional expansion of S206. (author)

Lithium ionophore VIII as an extraordinarily effective receptor for the strontium cation: Experimental and theoretical study

Czech Academy of Sciences Publication Activity Database

Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

2014-01-01

Roč. 1061, Mar 5 (2014), s. 110-113 ISSN 0022-2860 Institutional support: RVO:61388963 Keywords : strontium cation * lithium ionophore VIII * complexation * extraction and stability constants * DFT calculations * structures Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.602, year: 2014

Pedro Calderón de la Barca, Autos sacramentales - Francisco de Quevedo, Prosa satírica

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Fernando Plata

2012-12-01

Full Text Available Reviews of Pedro Calderón de la Barca, Autos sacramentales. El divino Jasón. El gran mercado del Mundo. El gran teatro del Mundo. La viña del Señor, ed. I. Arellano, Homo Legens (Bibliotheca Homolegens, 50, Madrid, 2010, 406 pp. ISBN: 978-84-92518-54-8 y Francisco de Quevedo, Prosa satírica, ed. I. Arellano, Homo Legens (Bibliotheca Homolegens, 58, Madrid, 2011, 206 pp. ISBN: 978-84-92518-69-2.

Edition and Traslation of the «Carta a lord Burghley» by Pedro Sarmiento de Gamboa

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Andrés Eichmann Oehrli

2016-05-01

Full Text Available In the following article we present an unpublished and unknown text of Galician discoverer Pedro Sarmiento de Gamboa. The letter, wrote in Latin, was send to Lord Burghley, the first minister of Elizabeth Tudor. Its content links chro-nicles and legends of Spain and Galicia to the genealogy of Sarmiento de Gamboa. Here, we offer the biographical context of the letter, a brief study of the sources, apart from the transcription of the original and the translation of the text into Spanish.

El plano secuencia: Pedro Costa y la trilogía de Fontainhas

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Vieguer, Marcelo

2012-01-01

Full Text Available [es] Desde la aparición del plano secuencia en forma expresiva con Citizen Kane, tal recurso se convirtió en sinónimo de modernidad cinematográfica. Ni tanto ni tan poco, el uso del plano secuencia, generalmente visible, se lo comprendió como maniera formal y toque de virtuosismo. Con el director portugués Pedro Costa, es posible entender de qué manera la crítica y teoría fílmica sobredimensionan criterios esté-ticos ante lo políticamente correcto. Con la realización de la trilogía sobre Fontainhas, Costa se ha convertido en uno de los directores excéntricos más relevantes de los últimos quince años. El recurrente uso del plano secuencia fílmico y su persuasión política a través de las imágenes discurre sobre las condiciones de producción y recepción del cine contemporáneo, poniendo énfasis en llevar a la luz del día del escenario audiovisual los sectores excluidos de su Lisboa, iniciando un periplo que comienza en Fontainhas. [en] Since the sequence shot expressively appeared with Citizen Kane, this resource became synonymous with cinematic modernity. Neither that much nor that little, the use of the sequence shot, usually visible, is understood as formal manieraand a touch of virtuosity. With the Portuguese director Pedro Costa it is possible to understand how film criticism and theory favor aesthetic criteria rather than what is politically correct. With the production of the trilogy about Fontainhas, Costa has become one of the most important marginal directors in the last fifteen years. The recurrent use of the film sequence shot and his political persuasion through images run on the conditions of production and reception of contemporary cinema, with a clear intention to bring into the light of audiovisual stage the excluded areas of Lisbon, starting a long journey that begins in Fontainhas.

Improving attitudes toward mathematics learning with problem posing in class VIII

Science.gov (United States)

Vionita, Alfha; Purboningsih, Dyah

2017-08-01

This research is classroom action research which is collaborated to improve student's behavior toward math and mathematics learning at class VIII by using problem posing approach. The subject of research is all of students grade VIIIA which consist of 32 students. This research has been held on two period, first period is about 3 times meeting, and second period is about 4 times meeting. The instrument of this research is implementation of learning observation's guidance by using problem posing approach. Cycle test has been used to measure cognitive competence, and questionnaire to measure the students' behavior in mathematics learning process. The result of research shows the students' behavior has been improving after using problem posing approach. It is showed by the behavior's criteria of students that has increasing result from the average in first period to high in second period. Furthermore, the percentage of test result is also improve from 68,75% in first period to 78,13% in second period. On the other hand, the implementation of learning observation by using problem posing approach has also improving and it is showed by the average percentage of teacher's achievement in first period is 89,2% and student's achievement 85,8%. These results get increase in second period for both teacher and students' achievement which are 94,4% and 91,11%. As a result, students' behavior toward math learning process in class VIII has been improving by using problem posing approach.

Aspectos fisiológicos e anatômicos de goiaba Pedro Sato em desenvolvimento

OpenAIRE

Cabrini, Elaine Cristina

2009-01-01

Frutos de goiabeira Pedro Sato foram acompanhados desde a sua formação até a senescência nas plantas, pelo período de 138 dias. As avaliações de peso, volume, diâmetros transversal e longitudinal indicaram que os frutos apresentaram curvas de crescimento do tipo sigmoidal simples, sendo que a etapa de crescimento rápido compreendeu o período entre o 77º e o 110º dias após a antese. As maiores taxas respiratórias foram observadas no início da formação dos frutos e o pico climatérico de produ...

On the phase characterization of the residues of the plant Comandante Pedro Soto Alba

International Nuclear Information System (INIS)

Diaz Ruano, A.; Fernandez Miranda, J.

1980-04-01

It has been studied of the phases present in the solid industrial residues of the plant Comandante Pedro Soto Alba (Moas's tails). It is done a preliminary qualitative characterization by X ray diffraction. It is done a characterization by differential and gravimetric thermal analysis and a quantitative valuation of SO 3 and H 2 O present in the samples. A complex of S and Al is detected. The results of SO 3 are compared with those obtained by the gravimetric method to verify those of Al, an elemental analysis by neutron activation was solicitated. A formula for the complex of S and Al is proposed. (author)

Violencia rural intercomunitaria no sueste de Galicia. Un caso concreto: Moialde contra San Pedro de Pousada

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Alonso Gayoso, Emilio

2015-12-01

Full Text Available The objective of this work is make an approximation to the research about the rural violence across the analysis of the conflict between two villages in the southeast of Galicia (Santa Maria de Moialde and San Pedro de Pousada, by economic and social causes, means of a cualitative research and the interview of several witness, with the design to determinate the most probable causes of the conflict between the communities, in economic and social nature. With the obtained dates, we reach to the conclusion that the most part of the rural conflict in the studied ambit begin in the competition to access to the single women and to the comunal goods, needful to the daily survival.El objetivo de este trabajo es realizar una aproximación al estudio de la violencia rural a través del análisis de los conflictos entre dos aldeas del sudeste de Galicia (Santa María de Moialde y San Pedro de Pousada, tanto por motivos económicos como sociales, mediante una investigación cualitativa y la entrevista de varios testigos, con la intención de determinar las causas más probables de los conflictos entre comunidades, tanto de naturaleza social como económica. A partir de los datos obtenidos se llega a la conclusión de que la mayoría de los conflictos rurales en el ámbito estudiado se originan en la competencia por las mujeres solteras y por el acceso a los bienes comunales, necesarios para la supervivencia cotidiana. [gl] O obxectivo deste traballo é facer unha aproximación ao estudo da violencia rural a través da análise dos conflitos entre dúas aldeas do sueste de Galicia (Santa María de Moialde e San Pedro de Pousada, tanto por motivos económicos como sociais, mediante unha investigación cualitativa e a entrevista de varias testemuñas, coa intención de determinar as causas máis probables dos conflitos entre comunidades, tanto de natureza social como económica. A partir dos datos obtidos chégase á conclusión de que a maioría dos conflitos

Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Young, M.; Antonarakis, S.E. [Univ. of Geneva (Switzerland); Inaba, Hiroshi [Tokyo Medical College (Japan)] [and others

1997-03-01

Although the molecular defect in patients in a Japanese family with mild to moderately severe hemophilia A was a deletion of a single nucleotide T within an A{sub 8}TA{sub 2} sequence of exon 14 of the factor VIII gene, the severity of the clinical phenotype did not correspond to that expected of a frameshift mutation. A small amount of functional factor VIII protein was detected in the patient`s plasma. Analysis of DNA and RNA molecules from normal and affected individuals and in vitro transcription/translation suggested a partial correction of the molecular defect, because of the following: (i) DNA replication/RNA transcription errors resulting in restoration of the reading frame and/or (ii) {open_quotes}ribosomal frameshifting{close_quotes} resulting in the production of normal factor VIII polypeptide and, thus, in a milder than expected hemophilia A. All of these mechanisms probably were promoted by the longer run of adenines, A{sub 10} instead of A{sub 8}TA{sub 2}, after the delT. Errors in the complex steps of gene expression therefore may partially correct a severe frameshift defect and ameliorate an expected severe phenotype. 36 refs., 6 figs.

Pedro Antonio Somellera y su concepción utilitarista del derecho

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Martín Laclau

2014-07-01

Full Text Available En las primeras décadas del siglo XIX, fue perceptible el notable influjo y difusión que cobraron las concepciones reformistas de Jeremy Bentham, tanto en el campo de las ideas morales y políticas como en el de las instituciones jurídicas. En su doctrina, todos los productos de la actividad legislativa e institucional eran evaluados desde la perspectiva de la utilidad, considerando que la utilidad de las instituciones debia ser medida por el grado con que ellas contribuyesen al logro de la mayor felicidad del mayor número posible de individuos.(...(...Veamos, a continuación, en forma sumaria, el sentido y las líneas generales de su pensamiento, para comprobar como el mismo se refleja en las doctrinas jurídicas expuestas por Pedro Somellera en sus Principios de Derecho Civil.

Influence of V/III growth flux ratio on trap states in m-plane GaN grown by ammonia-based molecular beam epitaxy

International Nuclear Information System (INIS)

Zhang, Z.; Arehart, A. R.; Hurni, C. A.; Speck, J. S.; Ringel, S. A.

2012-01-01

Deep level transient spectroscopy (DLTS) and deep level optical spectroscopy (DLOS) were utilized to investigate the behavior of deep states in m-plane, n-type GaN grown by ammonia-based molecular beam epitaxy (NH 3 -MBE) as a function of systematically varied V/III growth flux ratios. Levels were detected at E C - 0.14 eV, E C - 0.21 eV, E C - 0.26 eV, E C - 0.62 eV, E C - 0.67 eV, E C - 2.65 eV, and E C - 3.31 eV, with the concentrations of several traps exhibiting systematic dependencies on V/III ratio. The DLTS spectra are dominated by traps at E C - 0.14 eV and E C - 0.67 eV, whose concentrations decreased monotonically with increasing V/III ratio and decreasing oxygen impurity concentration, and by a trap at E C - 0.21 eV that revealed no dependence of its concentration on growth conditions, suggestive of different physical origins. Higher concentrations of deeper trap states detected by DLOS with activation energies of E C - 2.65 eV and E C - 3.31 eV in each sample did not display measureable sensitivity to the intentionally varied V/III ratio, necessitating further study on reducing these deep traps through growth optimization for maximizing material quality of NH 3 -MBE grown m-plane GaN.

Libros adquiridos por don Pedro Fermín de Vargas en sus viajes por las Antillas

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Sergio Elías Ortíz

1962-04-01

Full Text Available Entre los papeles relacionados con la vida de Don Pedro Fermín de Vargas, que pueden consultarse en el Archivo General de Indias de Sevilla, hay una carta de él y una lista de libros que envía al Administrador de Correos de la Habana, Don José Fuertes, antiguo amigo suyo, luego su corresponsal y a la  vez espía de sus pasos para aprisionarlo, con el objeto de que se los guardase “en algún rincón de sus casa”.

Apropiación ciudadana de la ciencia y la tecnología. El caso de Pedro Figari.

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Agustín Courtoisie

2015-05-01

Full Text Available La apropiación ciudadana de la ciencia y la tecnología suele ocupar la atención académica principalmente en lo referido al uso creciente de nuevas tecnologías y la horizontalidad  de las comunicaciones propias de la globalización.  El artículo procura complementar esa mirada con una perspectiva histórica y analiza la labor de Pedro Figari en el Uruguay como un caso de apropiación ejemplar.

La introducción del arte flamígero en Castilla: Pedro Jalopa, maestro de los Luna

OpenAIRE

Yuste Galán, Amalia María

2004-01-01

Don Alvaro de Luna, at the height of his power, decided to build a funerary chapel in Toledo Cathedral. In relation to this project Pedro Jalopa appears, possibly the same master who some years earlier had directed the construction of Huesca Cathedral under the patronage of Pope Benedict XIII, great-uncle of Don Alvaro. After his work in Toledo, Jalopa was contracted as master builder at Palencia Cathedral. The powerful Luna family and the close relationship between bishoprics may well have i...

La fiesta xita: patrimonio biocultural mazahua de San Pedro el Alto, México

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Alicia Y. Vásquez González

2016-01-01

Full Text Available Ante la crisis ambiental y de la modernidad, se propone conservar la riqueza cultural y biológica de la humanidad como patrimonio. Así, se valora y revalora el patrimonio vivo, como es la relación entre culturas y biodiversidad, que se manifiestan en paisajes y territorios de los pueblos originarios. Se propone la fiesta xita (viejos como patrimonio biocultural de la milpa mazahua. El estudio etnográfico se realizó en San Pedro el Alto, México. La fiesta xita es parte del patrimonio biocultural mazahua, mediante la cual se entretejen agrobiodiversidad y cultura, lo que permite que los mazahuas mantengan y desarrollen sus actividades sociales y culturales que han sido heredadas de generación en generación.

Obtenção e caracterização de anticorpo monoclonal murino anti-fator VIII da coagulação sangüínea Attainment and characterization of murine monoclonal anti-factor VIII antibodies

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Rosana Rossi-Ferreira

2006-06-01

Full Text Available Entre os avanços da engenharia celular e biotecnologia nas últimas décadas, destaca-se a produção de anticorpos monoclonais murinos (AcMm utilizados no aprimoramento diagnóstico nas rotinas laboratoriais. A produção de fator VIII de alta pureza sempre foi o desejo e a preocupação das indústrias de hemoderivados para tratamento de pacientes portadores de hemofilia A, porém este produto inexiste no Brasil, sendo necessária sua obtenção no mercado internacional a custos elevados. O trabalho tem por objetivo a produção de AcMm anti-fator VIII humano (FVIII H através da expansão dos clones e caracterização imunoquímica do anticorpo. Camundongos Balb/c foram imunizados com FVIII H purificado como também proveniente de crioprecipitado e as células esplênicas dos animais foram fusionadas com células mielomatosas murinas segundo o método descrito por Kohler e Milstein para produção de híbridos em cultura. Foram testados 1.983 híbridos dos quais 105 foram submetidos à clonagem. Destes, 39 obtiveram monoclonalidade e 7 destes clones foram caracterizados através de técnicas de immunoblotting. Foram submetidas à purificação por cromatografia três imunoglobulinas de diferentes classes pertencentes aos clones LAMB1-10A1A4, LAMB1-17A1A1 e LAMB1-24A2A1. A imunoglobulina purificada pertencente ao clone LAMB1-10A1A4 foi adsorvida em coluna de imunoafinidade para purificação de concentrado de FVIII proveniente de crioprecipitado plasmático.Among the advances in cellular engineering and biotechnology over the last decades, the production of murine monoclonal antibodies (AcMm, used to improve laboratory diagnoses, stands out. The production of very pure factor VIII has always been a concern of suppliers of blood products to treat patients with hemophilia A and this product is still not produced in Brazil. Hence, it can only be attained on the international market at a high cost. The aim of this work was to produce AcMm anti

MANIFIESTOS Y UTOPÍAS, VIAJES Y VIDENCIA: UNA LECTURA MÍSTICA DE PEDRO PRADO

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Patricio Lizama

2012-11-01

Full Text Available En este trabajo estudiamos textos de Pedro Prado desde una perspectiva mística, la cual es entendida por el autor con un fundamento religioso y otro ético-social. Por ello, sus personajes se elevan hacia niveles últimos de realidad, pero no se apartan de la "tierra de hombres" y se convierten en videntes que anhelan la belleza y la justicia. En "La barca", los personajes realizan un viaje horizontal y otro vertical para enfrentar el misterio; enAlsino, el viaje vertical es también para acercarse a la divinidad y el horizontal para enjuiciar el mundo rural chileno. La mediación entre el arriba y el abajo se representa con una embarcación que navega y vuela y con un hombre que camina y vuela, ambas figuras entendidas como alegorías del artista.This paper provides an analysis of the writings by Pedro Prado from a mystical perspective, an approach that the author himself understands as having religious as well as socio-ethical foundations. This is why Prado's characters rise towards ultimate levels of reality, but they never lose touch with the "land of men" to the point of turning into seers who yearn for beauty andjustice. In "La barca", the characters undertake a vertical ass well ass a horizontal journey in order to face the mystery. In Alsino, on the other hand, the vertical journey also serves to approach the divine, whereas the horizontal one is used to judge the Chilean rural world. The mediation between that which is above and what is below is represented by a ship that sails and flies, as well as by a man who walks and flies, both of which are to be seen as allegories of the artist.

Structural Mimics of the [Fe]-Hydrogenase: A Complete Set for Group VIII Metals.

Science.gov (United States)

Barik, Chandan Kr; Ganguly, Rakesh; Li, Yongxin; Leong, Weng Kee

2018-06-18

A set of structural mimics of the [Fe]-hydrogenase active site comprising all the group VIII metals, viz., [M(2-NHC(O)C 5 H 4 N)(CO) 2 (2-S-C 5 H 4 N)], has been synthesized. They exist as a mixture of isomers in solution, and the relative stability of the isomers depends on the nature of the metal and the substituent at the 6-position of the pyridine ligand.

Ingenio etnográfico y tradición poética en el Canto II de «Arauco domado» de Pedro de Oña (1596

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Rodrigo Faúndez Carreño

2018-06-01

Full Text Available El presente artículo estudia los elementos de tradición y modernidad en el canto II de la epopeya Arauco domado de Pedro de Oña, publicada en Lima en 1596. Este canto retrata una serie de ritos y prácticas mágicas del mundo mapuche a través de las cuales se busca conocer el futuro de la guerra de Arauco: una obser­vación al cielo astral (estrellas y planetas y una posterior invocación al Demonio. Se presentan los principales modelos literarios que Pedro de Oña utiliza para construir estos pasajes, como sus aspectos etnográficos novedosos que le permiten actuali­zar y modificar la tradición poética de Occidente.

FACTORES ASOCIADOS A LA CONDUCTA DE LACTANCIA MATERNA EXCLUSIVA HASTA EL SEXTO MES DE LA VIDA EN NIÑOS Y NIÑAS DE LA COMUNA DE SAN PEDRO DE LA PAZ

OpenAIRE

ROMERO GARCIA, STEPHANIE

2012-01-01

Introducción: La comuna de San Pedro de la Paz posee una baja prevalencia de lactancia materna exclusiva en todos sus períodos reportados. Objetivo: Identificar los factores asociados a la conducta de lactancia materna exclusiva en niños/as hasta el octavo mes de vida, que estén bajo control en la red asistencial de la comuna de San Pedro de la Paz. Material y Métodos: Estudio descriptivo transversal mediante aplicación de encuesta en domicilio a 253 madres de niños/as de 1 a 8 meses de vi...

IMPLIKASI YURIDIS PUTUSAN MK NOMOR 46/PUU- VIII/ 2010 TERHADAP AKTA KELAHIRAN ANAK LUAR KAWIN

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Djumikasih Djumikasih

2014-08-01

Full Text Available Abstract This paper aims to identify and analyze what the juridical implications of the publication of the decision of the Constitutional Court No. 46/PUU-VIII / 2010 on Child Outside Marriage Deed which has been published by the Department of Population and Civil Registration prior to the establishment of the Constitutional Court's decision . The method used in this study is a normative juridical approach legislation. From the discussion, it can be concluded that the Constitutional Court 46/PUU-VIII/2010 Number of Tests on Article 43 paragraph ( 1 Marriage Act ( Act No. 1 of 1974 when viewed from the angle of legal certainty it will lead to legal certainty . But the decision will not have any juridical implications of the child's birth certificate that has been published outside of marriage and illegitimate child who was born before the date of February 17, 2012, as if enacted would be contrary to the principle of legality is interpreted Article 47 of the Law on the Constitutional Court and Article 28 ( i of the 1945 Constitution . Likewise, if the terms of the fairness and usefulness , especially for justice seekers / applicant , the timing of this decision is not fair and not useful , because although the Court granted the petition but the Constitutional Court can not be applied to her .   Key words: yuridical implication, birth certificate, children who are born outside of marriage   Abstrak   Tulisan ini bertujuan untuk mengetahui dan menganalisis apa implikasi yuridis dari terbitnya putusan MK Nomor 46/PUU-VIII/ 2010 terhadap Akta Anak Luar Kawin yang sudah diterbitkan oleh Dinas Kependudukan dan Catatan Sipil sebelum lahirnya putusan MK tersebut. Metode yang digunakan dalam penelitian ini adalah yuridis normative dengan pendekatan perundang-undangan. Dari pembahasan dapat disimpulkan bahwa Putusan MK Nomer 46/PUU-VIII/2010 tentang Pengujian terhadap Pasal 43 ayat (1 UU Perkawinan (UU NO 1 Tahun 1974 jika dilihat dari sudut kepastian

The philologist Pedro Martínez López: an imaginative liberal lampoonist | El filólogo Pedro Martínez López: un libelista liberal imaginativo

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Aline Vauchelle-Haquet

2006-12-01

Full Text Available In 1830, the philologist Pedro Martínez López was forced to go into exile in France for political reasons. In 1832, he published Representación a Fernando VII, rey de España, a lampoon in which he made a whole string of accusations against the tyrant. At the end of the following year, he published España en 1833, al expirar Fernando VII, another lampoon in which he blamed the king's despotic reign for the country's disastrous situation and asserted that such abuses and injustices could only be remedied by re-establishing the Constitution of Cádiz of 1812. In 1834, he ceased to rail against his political enemies, changed strategy, and using his considerable imagination, wrote a kind of fable entitled Una noche en el infierno, vista entre sueños. With a mixture of humour and acid wit, it told of how all the devils in the Kingdom of Darkness, embracing the «sacred» cause of liberalism, vented their anger on the deceased Ferdinand and his followers, who were still in power. It would appear that the work was a success, since it was republished in 1836. In 1835, disillusioned with the tepid and conservative liberal regime of the Estatuto Real, Martínez López wrote another story, Las Brujas en Zugarramurdi, in which different satanic creatures, this time sorceresses, take it upon themselves to defeat moderantismo and establish a progressive regime. After this, he ceased to publish lampoons and political parables and devoted himself to producing learned works, bringing out various dictionaries and grammars which were republished several times. | En 1830, el filólogo Pedro Martínez López tuvo que exiliarse a Francia por motivos políticos. En 1832, sacó a luz en Burdeos una Representación a Fernando VII, rey de España, panfleto en el que espetaba toda una sarta de acusaciones contra el tirano. A finales del año siguiente, publicó La España en 1833, al expirar Fernando VII, otro libelo en que responsabilizaba al despotismo de la

Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A

DEFF Research Database (Denmark)

Hvas, Anne-Mette; Sørensen, Hanne Thykjær; Norengaard, Lisbeth

2007-01-01

examined whether the clot stability in hemophiliacs could be improved by treatment with tranexamic acid (TXA) in combination with recombinant factor VIII (rFVIII). PATIENTS/METHODS: Baseline blood samples were obtained from eight males with severe hemophilia A. Thereafter, a bolus injection of r...

Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor

International Nuclear Information System (INIS)

Repke, D.; Gemmell, C.H.; Guha, A.; Turitto, V.T.; Nemerson, Y.; Broze, G.J. Jr.

1990-01-01

The effect of factors VIII and IX on the ability of the tissue factor-factor VIIa complex to activate factor X was studied in a continuous-flow tubular enzyme reactor. Tissue factor immobilized in a phospholipid bilayer on the inner surface of the tube was exposed to a perfusate containing factors VIIa, VIII, IX, and X flowing at a wall shear rate of 57, 300, or 1130 sec -1 . The addition of factors VIII and IX at their respective plasma concentrations resulted in a further 2 endash-to 3 endash fold increase. The direct activation of factor X by tissue factor-factor VIIa could be virtually eliminated by the lipoprotein-associated coagulation inhibitor. These results suggest that the tissue factor pathway, mediated through factors VIII and IX, produces significant levels of factor Xa even in the presence of an inhibitor of the tissue factor-factor VIIa complex; moreover, the activation is dependent on local shear conditions. These findings are consistent both with a model of blood coagulation in which initiation of the system results from tissue factor and with the bleeding observed in hemophilia

QUALIDADE DE GOIABAS ‘PEDRO SATO’ EM FUNÇÃO DE TRATAMENTOS ALTERNATIVOS EM PÓS-COLHEITA

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MARIA CECÍLIA DE ARRUDA PALHARINI

2016-02-01

Full Text Available RESUMO Este trabalho teve como objetivo avaliar o efeito de produtos alternativos e termoterapia, isoladamente e em associação, na qualidade físico-química e no controle das podridões de goiabas ‘Pedro Sato’. Inicialmente, foi avaliado o efeito dos tratamentos em pós-colheita com cloreto de cálcio, fosfito de potássio, 1-metilciclopropeno (1-MCP, fécula de mandioca, etanol seguido de cloro (etanol+cloro e termoterapia, durante oito dias de armazenamento dos frutos a 22ºC. Em uma segunda etapa, quatro tratamentos foram selecionados (fécula de mandioca, 1-MCP, termoterapia e etanol+cloro e avaliados em associação de dois, aplicados de forma sequencial, durante oito dias de armazenamento dos frutos a 25ºC. Os tratamentos 1-MCP e fécula foram os mais eficazes em manter a qualidade físico-química das goiabas ‘Pedro Sato’, retardando a perda de massa, a mudança de coloração da casca e contribuindo para a retenção da firmeza. Constatou-se maior redução de frutos com podridão nos tratamentos com termoterapia, fécula de mandioca e 1-MCP. As associações de tratamento com 1-MCP/fécula de mandioca e termoterapia/fécula foram os tratamentos mais eficazes em manter a qualidade das goiabas ‘Pedro Sato’, retardando a perda de massa, a mudança de coloração da casca e a redução da firmeza. As associações de tratamento reduziram a ocorrência de podridões, com destaque para os tratamentos com etanol+cloro/termoterapia e termoterapia/fécula, que foram mais eficientes até o quarto dia de armazenamento. Observou-se correlação entre a incidência de podridões e os parâmetros cor da casca e firmeza da polpa para a maioria das associações de tratamentos. De maneira geral, recomenda-se o tratamento com termoterapia/fécula para goiabas armazenadas a 22-25ºC, como forma de manutenção da qualidade físico-química e atrasando em, pelo menos, dois dias os sintomas de podridões.

Aproximación a la vida y obra del pintor y estofador alcalaíno-granadino Pedro Raxis

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Gila Medina, Lázaro

2003-12-01

Full Text Available This article offers an approximation to the life and work of Pedro de Raxis, a key artist in Counter Reformation Granada. Raxis was the nephew of the sculptor Pablo de Rojas, who was also the master of Juan Martinez Montañés. All three were from Alcalá de Henares and pioneers in the stylistic transition from the Roman Renaissance to early Baroque naturalism. Raxis also established an extremely active studio, precursor in the formation of famous artists, and during his lifetime was considered to be the "father" of the estofa technique (the sizing, gilding and painting of wooden statuary, although his facet as a painter was underestimated.

En el presente trabajo realizamos una aproximación a la vida y la obra de un artista clave para la Granada de la Contrarreforma: Pedro de Raxis, sobrino carnal del escultor Pablo de Rojas -maestro a su vez del también alcalaíno Juan Martínez Montañés-, todos ellos figuras pioneras al enmarcar el paso del renacimiento romanista al primer naturalismo barroco. Creador, igualmente, de un activísimo taller, precursor en la formación de renombrados artistas, fue considerado en su época como el "padre de la estofa", aunque se infravaloró su faceta de pintor.

Conocimiento de la atención del paro cardiorrespiratorio en médicos del Hospital Pedro de Bethancourt

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Henry Samayoa

2017-03-01

Full Text Available El paro cardiorrespiratorio (PCR es el cese de la respiración y el latido cardiaco en una persona. Las maniobras de reanimación cardiopulmonar (RCP son el conjunto de maniobras que se realizan con la finalidad de sustituir y restaurar la circulación y respiración espontánea en un paciente en PCR. El objetivo fue evaluar el conocimiento de la atención del PCR según Guías AHA 2010 en los médicos que laboran durante el año 2014 en el Hospital Pedro de Bethancourt de la Antigua Guatemala. Se realizó un estudio descriptivo comparativo. Para evaluar el conocimiento de la atención del PCR entre los médicos jefes (especialistas y médicos residentes, se utilizó un cuestionario de 30 preguntas sobre conocimientos de soporte vital básico y avanzado. Se logró la participación de 104 médicos. El promedio de calificación fue de 33 puntos para los Médicos Jefes y de 23 puntos para los Médicos Residentes. Los médicos que laboran en el Hospital Pedro de Bethancourt no tienen el conocimiento óptimo de la atención del PCR avanzado según las Guías de la AHA 2010.

La imagen de D. Pedro y D. Miguel en la novela histórica portuguesa del siglo XIX

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Beatriz Peralta García

2005-01-01

Full Text Available La revolución liberal en Portugal tuvo su reflejo en la literatura de la segunda mitad del siglo xix. La novela histórica de actualidad aborda los acontecimientos políticos más importantes con el objetivo de consolidar el nuevo estado liberal tras los enfrentamientos con los absolutistas. La imagen que de los infantes D. Pedro, liberal, y D. Miguel, absolutista, se difunde, caracteriza con éxito a ambos personajes, creando un estereotipo que se mantiene hasta la actualidad. El objetivo del trabajo es analizar los diferentes procesos que se utilizan para la identificación de esta figuras así como su trasfondo político.The liberal revolution in Portugal had his reflex in the literature of the second half of the xixth century. The historical novel of current importance approaches the most important political events with the aim(lens to consolidate the new liberal condition(state after the clashes with the absolutists. The image that of the infantes D. Pedro, liberal, and D. Michael, absolutist, spreads, characterizes successfully both prominent figures, creating a stereotype that is kept up to the current importance. The aim(lens of the work is to analyze the different processes that are in use for the identification of this one you appear as well as his political background.

Processamento mínimo em goiabas 'Paluma' e 'Pedro Sato': 2. Avaliação química, sensorial e microbiológica Minimal processament in "Paluma" and "Pedro Sato" guava fruit: 2. Chemical, sensorial e microbiological evaluation

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Ben-Hur Mattiuz

2003-12-01

Full Text Available Foram utilizados frutos de goiabeiras das cultivares "Pedro Sato" e "Paluma", provenientes de pomar comercial, no estádio de maturação "de vez", correspondente à coloração verde-mate e considerados "ótimo para o consumo". Os frutos foram inicialmente imersos em solução de hipoclorito de sódio (150mg de cloro.L-1 por 5 minutos, para desinfecção superficial. Pessoas treinadas, utilizando proteção adequada e equipamentos desinfetados descascaram os frutos, cortaram-nos longitudinalmente ao meio e eliminaram a polpa com as sementes, em ambiente a 12°C. Após enxágüe com água clorada (20mg de cloro.L-1 foram embalados em contentores de tereftalato de polietileno (PET com tampa. Estas unidades foram armazenadas a 3°C por 10 dias. Foram realizadas análises microbiológicas ao longo do período. Determinaram-se quimicamente os conteúdos de lignina, ácido ascórbico, acidez total titulável, sólidos solúveis totais e porcentagem de solubilização das pectinas, bem como as variáveis sensoriais de textura, sabor e preferência. A textura tornou-se mais frágil e os conteúdos de ácido ascórbico se reduziram, ao longo do período de armazenamento, nos produtos de ambas as cultivares. Durante este período houve aumento no conteúdo de lignina e manutenção dos conteúdos de sólidos solúveis totais (SST, acidez total titulável (ATT e da relação SST/ATT. O produto da cultivar "Pedro Sato" apresentou menor perda de textura que o da 'Paluma', sendo considerado pelos provadores como o mais saboroso e, portanto, o mais preferido. Devido aos cuidados higiênicos tomados durante o processamento o produto apresentou baixa contagem microbiana (Two cultivars of guava fruit, Pedro Sato and Paluma, were studied. They were both obtained from a commercial orchard, at the maturation stage of "ready for harvest," corresponding to a dull-green coloration and considered "perfect for eating." The fruits were initially immersed in a solution of

Visualizing the Life and Legacy of Henry VIII: Guiding Students with Eight Types of Graphic Organizers

Science.gov (United States)

Gallavan, Nancy P.; Kottler, Ellen

2010-01-01

Delving into the life and legacy of Henry VIII is both complex and captivating. People seem compelled to learn more abut his critical contributions and controversial conduct that range from the significant to the scandalous. Reflecting on the history of the world would be incomplete without investigating the events and escapades associated with…

Acquired factor VIII inhibitor syndrome: A rare cause of hematuria

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Muthuvel Seral Kannan

2015-01-01

Full Text Available A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia. With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.

Eight years of millimetric atmospheric opacity Measurements at San Pedro Mártin sierra in Baja California

OpenAIRE

David Hiriart

2003-01-01

Se presentan los resultados de ocho a~nos de mediciones de la opacidad de la atm osfera a 210 GHz (1.4 mm) sobre la Sierra de San Pedro M artir B.C. Estos comprenden el periodo de 1995 a 2002, reportando mediciones de un total de 1570 d as. El valor medio de la opacidad al cenit obtenido fue de 0.23 nepers. Los valores de la opacidad al cenit durante el d a y la noche fueron 0.25 y 0.20 nepers, respectivamente. Durante el verano, se encontr o un marcado ascenso en la opacidad a...

Para travestirte mejor: Pedro Lemebel y las lecturas políticas desde los márgenes

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Efraín Barradas

2014-06-01

The Chilean author Pedro Lemebel has become one of the best writers of crónicas in Latin America. His books, written always from an openly gay and leftist point of view, portray, sometimes in an indirect fashion, his country’s problems. In an early piece, “Tarántulas en el pelo”, Lemebel explores the Latin American racial problem and returns to the 19th century polemic on the subject (Sarmiento versus Martí through an apparently funny and insignificant incident between a gay hairdresser and his client, a woman who represents the new Chilean bourgeoisie.

VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis. Program. Summary of reports

International Nuclear Information System (INIS)

2001-01-01

Program and summary of reports of the VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis are performed. The meeting took place 15-19 October, 2001 in Moscow. Many problems of liquid and ion exchange chromatography, capillary electrophoresis, thin-layer chromatography have been discussed extensively. Reports covering properties of sorbents and devices for chromatography are incorporated in the collection [ru

MENINGKATKAN AKTIVITAS BELAJAR SISWA DENGAN MENGGUNAKAN METODE GROUP INVESTIGATION (GI PADA POKOK BAHASAN PASAR DI KELAS VIII SMP 5 KUDUS

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Mutthofiyah Mutthofiyah

2016-03-01

Full Text Available Penelitian ini bertujuan untukmeningkatkan aktivitas belajar siswa dengan menggunakan metode group investigation (GI pada pokok bahasan pasar pada penelitian ini menggunakan penelitian tindakan kelas (PTK. Dalam penelitian ini dirancang menggunakan siklus, masing-masing siklus dengan tahapan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data pada penelitian ini adalah dokumentasi, observasi dan tes.Hasil penelitian menunjukkan melalui meningkatkan metode group investigation (GI aktivitas siswa SMP 5 Kudus ada peningkatan yang sigifikan, dari siklus I kelas VIII F 15,8 (41,62% meningkat di siklus II menjadi 24,8 (72,9%, sedangkan di kelas VIII G siklus I 18,5 (47,04% meningkat menjadi 26,2 (74,7%; melalui penerapan metode group investigation hasil belajar siswa SMP 5 kudus meningkat sangat signifkan, ketuntasan belajar secara klasikal dari kelas VIII F pra siklus sebesar 17,64% terjadi peningkatan 47% ke siklus I dan meningkat menjadi 82,35% di siklus II. Sedangkan di kelas VII G pra siklus sebesar 22,85% meningkat 54,28% di siklus I dan meningkat menjadi 94,28% di siklus II. Saran yang peneliti berikan adalah sebagai berikut:1Kepada para guru diharapkan dapat menerapkan pembelajaran kooperatif khususnya pembelajaran kooperatif tipe Group Investigation (GI dalam proses pembelajaran ekonomi dan mata pelajaran lainya dan mengembangkannya; 2 Kepada para peneliti selanjutnya diharapkan dapat melakukan penelitian tentang penerapan model pembelajaran yang dapat membangkitkan keaktifan siswa untuk belajar ekonomi. This study aims to improve students' learning activities using group investigation (GI on the subject of markets in class VIII SMP 5 Kudus. In this study is designed to use cycles, with each cycle stages of planning, action, observation and reflection. Data collection techniques in this study is documentation, observation and tests. Results showed through improved methods of group investigation (GI junior 5 high

QUALIDADE DE GOIABAS ‘PEDRO SATO’ EM FUNÇÃO DE TRATAMENTOS ALTERNATIVOS EM PÓS-COLHEITA

OpenAIRE

PALHARINI,MARIA CECÍLIA DE ARRUDA; FISCHER,IVAN HERMAN; ALVES,AGHATA REGINA DE OLIVEIRA FERREIRA; FILETI,MIRIAN DE SOUZA; NOGUEIRA JÚNIOR,ANTÔNIO FERNANDES

2016-01-01

RESUMO Este trabalho teve como objetivo avaliar o efeito de produtos alternativos e termoterapia, isoladamente e em associação, na qualidade físico-química e no controle das podridões de goiabas ‘Pedro Sato’. Inicialmente, foi avaliado o efeito dos tratamentos em pós-colheita com cloreto de cálcio, fosfito de potássio, 1-metilciclopropeno (1-MCP), fécula de mandioca, etanol seguido de cloro (etanol+cloro) e termoterapia, durante oito dias de armazenamento dos frutos a 22ºC. Em um...

Isidore of Seville and comici ueteres. Ad Isid., Orig. VIII 7.7

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Krzysztof Rzepkowski

2012-12-01

Full Text Available In chapter 7 of book VIII of Etymologies dedicated to Roman poets (De poetis, Isidore draws a dividing line between the so-called ueteres and noui comici. Among ueteres he counts Plautus, Accius, Terentius, although Accius, according to our knowledge, composed only tragedies and can hardly be considered a comic playwright. In this paper I try to prove that all the palaeographic, phonetic, historical, and literary arguments speak in favour of emending in the discussed passage the peculiar «Accius» to the expected «Caecilius» (i.e. Caecilius Statius.

AKTIVITAS FISIK, ASUPAN ENERGI DAN STATUS GIZI WANITA PEMETIK TEH DI PTPN VIII BANDUNG, JAWA BARAT

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Venny Agustiani Mahardikawati

2012-03-01

Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Quality of human resources is very important to improve productivity. The worker productivity is correlated with nutritional status and health status. The objective of the research is to analyze physical activity, energy intake, nutritional status, of women workers at Tea Plantation PTPN VIII Bandung, West Java. The cross sectional design was used in this study to elaborate physical activity, nutritional status, and productivity of tea picker’s women. The criteria of study sample were tea picker’s women at cluster area of Malabar tea plantation of PTPN VIII Bandung, having infant and they were willing to be interviewed. The total number of 92 women sample was chosen randomly. Primary data consisted of physical activity recall (2x24 hours, food consumption recall (2x24 hours, anthropometry data (weight and height, and productivity (passage of tea sprout. Secondary data were included data of PT Perkebunan Nusantara VIII Bandung, West Java. The result showed that more than a half of samples having active or moderate physical activity level (PAL. The physical activity level of samples during work day (average PAL=1.87 was higher than holiday (average PAL=1.69 (p2362 kcal and 2134 kcal. The average energy adequacy level during workday and day off according to Schofield and Oxford equation were not significantly different, respectively 97,2% and 103,3%. The majority of samples had normal nutritional status, and 30.4% of the sample was overweight. The energy adequacy level according to Schofield and Oxford equation are related to nutritional status of women workers. Keywords: physical activity, energy expenditure, nutritional status, plantation women

Molecular characterization of a novel family VIII esterase from burkholderia multivorans UWC10

CSIR Research Space (South Africa)

Rashamuse, KJ

2007-02-01

Full Text Available et al., 1992). Here we report the cloning, purification, and 3D model of a novel family VIII esterase from Burkholderia multivorans UWC10. To our knowledge no report of esterolytic activity from B. multivorans is currently available. METHODOLOGY... stream_source_info Rashamuse1_2007_d.pdf.txt stream_content_type text/plain stream_size 9884 Content-Encoding UTF-8 stream_name Rashamuse1_2007_d.pdf.txt Content-Type text/plain; charset=UTF-8 Molecular Characterization...

Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

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Alexander, David

2004-12-01

Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

Extended analysis of Br VIII and predicted trends for the n=4, Δn=0 transistions of nickel-like ions (Kr IX-Mo XV)

International Nuclear Information System (INIS)

Wyart, J.F.; Ryabtsev, A.N.

1986-01-01

More than one hundred lines of Br VIII have been classified in the spectral region 416-824 A, from which all levels of 3d 9 4d (except 1 S 0 ) have been found. The energy levels of the configurations 3d 9 4s, 3d 9 4p and 3d 9 4d have been interpreted from Zn III to Mo XV by means of the Slater-Condon theory and of generalized least squares techniques and the root mean square deviations are 8, 51 and 40 cm -1 respectively. The strongest lines of the 4s-4p and 4p-4d transitions are predicted from Kr IX to Mo XV. (orig.)

Hydrogeologic framework of the middle San Pedro watershed, southeastern Arizona

Science.gov (United States)

Dickinson, Jesse; Kennedy, Jeffrey R.; Pool, D.R.; Cordova, Jeffrey T.; Parker, John T.; Macy, J.P.; Thomas, Blakemore

2010-01-01

the upper basin fill may be more permeable than the lower basin fill, but it is generally unsaturated in the study area. The lower basin fill stratigraphic unit was delineated into three HGUs on the basis of lithologic descriptions in driller?s logs and one-dimensional (1D) electrical models of airborne transient electromagnetic (TEM) surveys. The interbedded lower basin fill (ILBF) HGU represents an upper sequence having resistivity values between 5 and 40 ohm-m identified as interbedded sand, gravel, and clay in driller?s logs. Below this upper sequence, fine-grained lower basin fill (FLBF) HGU represents a thick silt and clay sequence having resistivity values between 5 and 20 ohm-m. Within the coarse-grained lower basin fill (CLBF) HGU, which underlies the silt and clay of the FLBF, the resistivity values on logs and 1D models increase to several hundred ohm-m and are highly variable within sand and gravel layers. These sequences match distinct resistivity and lithologic layers identified by geophysical logs in the adjacent Sierra Vista subwatershed, suggesting that these sequences are laterally continuous within both the Benson and Sierra Vista subwatersheds in the Upper San Pedro Basin. A subsurface density model based on gravity data was constructed to identify the top of bedrock and structures that may affect regional groundwater flow. The subsurface density model contains six layers having uniform density values, which are assigned on the basis of geophysical logs. The density values for the layers range between 1.65 g/cm3 for unsaturated sediments near the land surface and 2.67 g/cm3 for bedrock. Major features include three subbasins within the study area, the Huachuca City subbasin, the Tombstone subbasin, and the Benson subbasin, which have no expression in surface topography or lithology. Bedrock altitudes from the subsurface density model defined top altitudes of the bedrock HGU. The HFM includes the following HGUs in ascending stratigr

Long-term decrease in satellite vegetation indices in response to environmental variables in an iconic desert riparian ecosystem: the Upper San Pedro, Arizona, United States

Science.gov (United States)

Nguyen, Uyen; Glenn, Edward P.; Nagler, Pamela L.; Scott, Russell L.

2015-01-01

The Upper San Pedro River is one of the few remaining undammed rivers that maintain a vibrant riparian ecosystem in the southwest United States. However, its riparian forest is threatened by diminishing groundwater and surface water inputs, due to either changes in watershed characteristics such as changes in riparian and upland vegetation, or human activities such as regional groundwater pumping. We used satellite vegetation indices to quantify the green leaf density of the groundwater-dependent riparian forest from 1984 to 2012. The river was divided into a southern, upstream (mainly perennial flow) reach and a northern, downstream (mainly intermittent and ephemeral flow) reach. Pre-monsoon (June) Landsat normalized difference vegetation index (NDVI) values showed a 20% drop for the northern reach (P  0·05). NDVI and enhanced vegetation index values were positively correlated (P deterioration of the riparian forest in the northern reach.

Penerapan Model Learning Cycle 5E untuk Meningkatkan Keterampilan Berpikir Kritis Siswa Pada Materi Fluida Statis Kelas VIII

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Irhamna Irhamna

2017-08-01

Full Text Available Penerapan model learning cycle 5E telah dilakukan pada siswa kelas VIII dengan materi fluida statis. Penelitian ini bertujuan untuk mendapatkan gambaran mengenai peningkatan keterampilan berpikir kritis siswa setelah diterapkan model learning cycle 5E pada materi fluida statis. Bentuk desain penelitian yang digunakan adalah pre-experimental dengan one group pre-test post-test design. Populasi pada penelitian ini adalah seluruh siswa kelas VIII di SMP Torsina Singkawang. Teknik pengambilan sampel menggunakan sampling purposive yang berjumlah 23 orang. Hasil penelitian menunjukkan bahwa model learning cyle 5E dapat meningkatkan keterampilan berpikir kritis siswa yaitu pada indikator pemecahan masalah dengan skor N-gain sebesar 0,43 dengan kategori sedang, indikator membuat keputusan dengan skor N-gain sebesar 0,42 dengan kategori sedang, indikator penyelidikan percobaan dengan skor N-gain sebesar 0,33 dengan kategori sedang dan indikator menyimpulkan dengan skor N-gain sebesar 0,37 dengan kategori sedang.

The influence of growth temperature and input V/III ratio on the initial nucleation and material properties of InN on GaN by MOCVD

International Nuclear Information System (INIS)

Wang, H; Jiang, D S; Zhu, J J; Zhao, D G; Liu, Z S; Wang, Y T; Zhang, S M; Yang, H

2009-01-01

The effects of growth temperature and V/III ratio on the InN initial nucleation of islands on the GaN (0 0 0 1) surface were investigated. It is found that InN nuclei density increases with decreasing growth temperature between 375 and 525 °C. At lower growth temperatures, InN thin films take the form of small and closely packed islands with diameters of less than 100 nm, whereas at elevated temperatures the InN islands can grow larger and well separated, approaching an equilibrium hexagonal shape due to enhanced surface diffusion of adatoms. At a given growth temperature of 500 °C, a controllable density and size of separated InN islands can be achieved by adjusting the V/III ratio. The larger islands lead to fewer defects when they are coalesced. Comparatively, the electrical properties of the films grown under higher V/III ratio are improved

Interactions between western gall rust and its Pinus hosts, P. jeffreyi and P. contorta, in Sierra De San Pedro Martir National Park, Northern Baja California, Mexico

Science.gov (United States)

Detlev R. Vogler; Brian W. Geils

2008-01-01

The Sierra de San Pedro Martir is a mountain range in north-central Baja that comprises the southern-most extension of the Californian coniferous flora, including Pinus jeffreyi, P. contorta, P. lambertiana, Abies concolor, and Calocedrus decurrens. These forests are similar...

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

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Wang H

2018-05-01

Full Text Available Han Wang,1–3 Yao Wang,1–3 Wentao Guo,4 Bin Du,1–3 Xiaobing Huang,1–3 Riping Wu,1–3 Baoyu Yang,1–3 Xiaoyan Lin,1–3,5 Yilan Wu6 1Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Stem Cell Research Institute, Fujian Medical University, Fuzhou, People’s Republic of China; 3Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China; 4School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of China; 5Graduate School of Education, Fujian Medical University, Fuzhou, People’s Republic of China; 6School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, People’s Republic of China Background: Mutated anaplastic lymphoma kinase (ALK drives the development of advanced non-small cell lung cancer (NSCLC. Most reported small-molecule inhibitors targeting the ALK domain do not display good inhibition of the G1202R solvent front mutation. The solvent front mutation was assumed to hinder drug binding. However, a different fact could be uncovered by the simulations reported in this study through a structural analog of alectinib (JH-VIII-157-02, which demonstrated potent effects against the G1202R mutation. Methods: Molecular docking, conventional molecular dynamics (MD simulations, free energy calculations, and umbrella sampling (US simulations were carried out to make clear the principles of the binding preferences of alectinib and JH-VIII-157-02 toward ALKWT and the ALK G1202R (ALKG1202R mutation. Results: JH-VIII-157-02 has similar binding affinities to both ALKWT and ALKG1202R whereas it has has a much lower binding affinity for alectinib to ALKG1202R. Analysis of individual energy terms indicate the major variation involves the van der Waals and entropy terms. Structural analysis reveals that the conformational change of the ATP-binding glycine-rich loop was primarily responsible for the alectinib

Post-Palaeolithic - Palaeolithic pictorial sequences in the Sierra de San Pedro. International Tagus. Cáceres

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Bueno Ramírez, Primitiva

2010-06-01

Full Text Available The UAH team is developing successive projects of heritage evaluation in the International Tagus, focused on the megalithic culture. Our surveys, based on the theoretical statement of a predictive model that considers the presence of outdoor paintings, make the Sierra de San Pedro one of the most important schematic painting groups of the Iberian Peninsula. Its parallel development to the sites with outdoor engravings in the International Tagus draws a complex set of symbols with a major role in the definition of megalithic territories. The identification of Palaeolithic figures coincides with similar recurrences documented in outdoor sites of the western peninsula, pointing to the resort to the past as one of the arguments of vindication and use of traditional territories.

El equipo de la UAH viene desarrollando sucesivos proyectos de valoración patrimonial en el Tajo Internacional centrados en la cultura megalítica. Nuestras prospecciones a partir de la exposición teórica de un modelo predictivo que considera la presencia de pinturas al aire libre, hacen de la Sierra de San Pedro uno de los más importantes conjuntos de la pintura esquemática de la Península Ibérica. Su desarrollo paralelo a los yacimientos con grabados al aire libre del Tajo Internacional dibuja un complejo entramado de símbolos con un importante papel en la definición de los territorios megalíticos. La identificación de figuras paleolíticas coincide con recurrencias similares documentadas en los yacimientos al aire libre del occidente peninsular, apuntando al recurso al pasado como uno de los argumentos de reivindicación y uso de territorios tradicionales.

Radiação gama e atmosfera modificada passiva na qualidade de goiabas 'Pedro Sato'

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André José de Campos

2011-10-01

Full Text Available O objetivo deste trabalho foi avaliar o efeito da irradiação gama associada à atmosfera modificada passiva na qualidade pós-colheita de goiabas 'Pedro Sato', verificando suas características físico-químicas. Foram utilizadas goiabas provenientes da região de Vista Alegre do Alto-SP,Brasil. Após a colheita, as goiabas foram imediatamente transportadas ao Laboratório de Frutas e Hortaliças, pertencente ao Departamento de Gestão e Tecnologia Agroindustrial, da Faculdade de Ciências Agronômicas - UNESP - Câmpus de Botucatu-SP, onde foram armazenadas a 10ºC e 90-95%UR, em câmara frigorífica, por 28 dias. Os tratamentos foram: controle 1 (sem embalagem e sem irradiação; controle 2 (embalagem de poliestireno (PS + polietileno de baixa densidade (PEBD e sem irradiação; tratamento 1 (PS+PEBD e 0,2kGy; tratamento 2 (PS+PEBD e 0,6kGy, e tratamento 3 (PS+PEBD e 1,0kGy. As análises realizadas foram: firmeza, sólidos solúveis (SS, acidez titulável (AT e índice de maturação. Foi utilizado o delineamento inteiramente casualizado, com esquema fatorial 5 x 5 (tratamento x tempo. Concluiu-se que as altas doses de irradiação promoveram efeito negativo nas características físico-químicas da goiaba 'Pedro Sato', e que apenas a menor dose utilizada (0,2kGy associada à atmosfera modificada conservou frutos com maior qualidade e aceitabilidade, indicado por maiores índice de maturação e teor de sólidos solúveis obtidos.

Grotrian diagrams for highly ionized cobalt Co VIII through Co XXVII

Energy Technology Data Exchange (ETDEWEB)

Shirai, Toshizo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sugar, J.; Wiese, W.L.

1997-07-01

Grotrian diagrams are presented to provide graphical overviews for 1,247 spectral lines of highly ionized cobalt, Co VIII through Co XXVII. In the usual diagram display such as that by Bashkin and Stoner (North-Holland, Amsterdam, 1975), the density of transitions is often too high to allow each transition to be drawn separately. Here in our modified diagrams, the transitions are also represented by lines connecting the upper and lower energy levels, but the lower energy levels are extended and repeated for successive configurations as needed. As a sequence, dense packing is avoided and all lines in a multiplet can be accommodated. (author)

Comercio Internacional mediterráneo en el siglo VIII a.C.

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Paloma Cabrera Bonet

2018-01-01

Full Text Available The VIII century B.C. saw, for the first time after the breakdown of the system in the Late Bronze Age, the revival of a true intemational trade at a growing scale, especíally protagonized by Phoenicians and Greeks. In this article we analyze sorne aspects of this phenomenon, from the Aegean to the Far West, which made possíble, through a vaste network of trading routes, a large multinational ínteractíon. We understand the international trade as a key factor in the proccess of economic, social and political changes of the Mediterranean areas submerged in this complex "world-system".

The Safety and Feasibility of Three-Dimensional Visualization Technology Assisted Right Posterior Lobe Allied with Part of V and VIII Sectionectomy for Right Hepatic Malignancy Therapy.

Science.gov (United States)

Hu, Min; Hu, Haoyu; Cai, Wei; Mo, Zhikang; Xiang, Nan; Yang, Jian; Fang, Chihua

2018-05-01

Hepatectomy is the optimal method for liver cancer; the virtual liver resection based on three-dimensional visualization technology (3-DVT) could provide better preoperative strategy for surgeon. We aim to introduce right posterior lobe allied with part of V and VIII sectionectomy assisted by 3-DVT as a promising treatment for massive or multiple right hepatic malignancies to retain maximum residual liver volume on the basis of R0 resection. Among 126 consecutive patients who underwent hepatectomy, 9 (7%) underwent right posterior lobe allied with part of V and VIII sectionectomy. 21 (17%) underwent right hemihepatectomy (RH). The virtual RH was performed with 3-DVT, which provided better observation of spatial position relationship between tumor and vessels, and the more accurate estimation of the remnant liver volume. If remnant liver volume was right posterior lobe allied with part of V and VIII sectionectomy should be undergone. Then, the precut line ought to be planned on the basis of protecting the portal branch of subsegment 5 and 8. The postoperative outcome of patients was compared before and after propensity score matching. Nine patients meeting the eligibility criteria received right posterior lobe allied with part of V and VIII sectionectomy. The variables, including the overall mean operation time, blood transfusion, operation length, liver function, and postoperative complications, were similar between two groups before and after propensity matching. The postoperative first, third, fifth, and seventh days mean value of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin had no significant difference compared with preoperative value. One patient in each group had recurrence six months after surgery. Right posterior lobe allied with part of V and VIII sectionectomy based on 3-DVT is safe and feasible surgery way, and can be a very promising method in massive or multiple right hepatic malignancy therapy.

Analysis of inversions in the factor VIII gene in Spanish hemophilia A patients and families

Energy Technology Data Exchange (ETDEWEB)

Domenech, M.; Tizzano, E.; Baiget, M. [Hospital de Sant Pau, Barcelona (Spain); Altisent, C. [Hospital Vall d`Hebron, Barcelona (Spain)

1994-09-01

Intron 22 is the largest intron of the factor VIII gene and contains a CpG island from which two additional transcripts originate. One of these transcripts corresponds to the F8A gene which have telomeric extragenic copies in the X chromosome. An inversion involving homologous recombination between the intragenic and the distal or proximal copies of the F8A gene has been recently described as a common cause of severe hemophilia A (HA). We analyzed intron 22 rearrangements in 195 HA patients (123 familial and 72 sporadic cases). According to factor VIII levels, our sample was classified as severe in 114 cases, moderate in 29 cases and mild in 52 cases. An intron 22 (F8A) probe was hybridized to Southern blots of BcII digested DNA obtained from peripheral blood. A clear pattern of altered bands identifies distal or proximal inversions. We detected an abnormal pattern identifying an inversion in 49 (25%) of the analyzed cases. 43% of severe HA patients (49 cases) showed an inversion. As expected, no inversion was found in the moderate and mild group of patients. We found a high proportion (78%) of the distal rearrangement. From 49 identified inversions, 33 were found in familial cases (27%), while the remaining 15 were detected in sporadic patients (22%) in support that this mutational event occurs with a similar frequency in familial or sporadic cases. In addition, we detected a significant tendency of distal inversion to occur more frequently in familial cases than in sporadic cases. Inhibitor development to factor VIII was documented in approximately 1/3 of the patients with inversion. The identification of such a frequent molecular event in severe hemophilia A patients has been applied in our families to carrier and prenatal diagnosis, to determine the origin of the mutation in the sporadic cases and to detect the presence of germinal mosaicism.

“La logia dominicana Aurora Nº 82 de San Pedro de Macoris (1889-1923”

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José Antonio Ferrer Benimeli

2011-01-01

Full Text Available La logia Aurora Nº 82 de San Pedro de Macoris en Santo Domingo afrontó el contexto dominicano e internacional auspiciada por la obediencia española del Gran Oriente Español desde 1889 hasta 1923. Este trabajo traza la historia general de este taller en dicho periodo aportando respuestas a los siguientes interrogantes: ¿Cómo actuaron los masones de este taller en dicho contexto? ¿Cuál fue su relación con las obediencias dominicanas? ¿Cuáles fueron las principales actuaciones oficiales entre esta logia y las autoridades masónicas españolas? ¿Cuáles fueron los principales conflictos internos de la logia?

Ictiofauna de los humedales del río San Pedro, Balancán, Tabasco, México

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Alfonso Castillo-Domínguez

2011-06-01

Full Text Available Los humedales de San Pedro sostienen redes tróficas del sistema fluvial debido a la alta disponibilidad de hábitats y a sus variaciones espacio-temporales. En esta investigación se estudió la composición, densidad y biomasa de la ictiofauna de los humedales; se capturaron 1 049 organismos de 25 especies, dos son exóticas: Oreochromis niloticus y Parachromis managuense. Con 23 especies capturadas en el sitio I, 17 en el II y 14 en el III. En la época de secas se obtuvo mayor riqueza con 21 especies, lluvias con 17 y cinco en nortes. La mayor densidad se mostró en el sitio II (0.23ind./m², seguido de los sitios I y III (0.12, 0.12ind./m². La mayor biomasa fue en secas (8.30g/m², seguida de lluvias (2.1g/m² y por último nortes (0.01g/m². La mayor densidad se mostró en secas (0.43ind./m² y la mínima en nortes (0.023ind./m². Las especies dominantes en densidad según el diagrama Olmstead-Tukey fueron: Petenia splendida, Vieja heterospila, Vieja synspila, Dorosoma petenense y Astyanax aeneus. Por lo tanto, existieron diferencias significativas en los parámetros ecológicos y ambientales. Al considerar la variación en la riqueza podemos concluir que los humedales del río San Pedro, es un sistema donde la composición de la ictiofauna responde a las fluctuaciones espaciales y temporales.

Development of Integrated Natural Science Teaching Materials Webbed Type with Applying Discourse Analysis on Students Grade VIII in Physics Class

Science.gov (United States)

Sukariasih, Luh

2017-05-01

This study aims to produce teaching materials integrated natural science (IPA) webbed type of handout types are eligible for use in integrated science teaching. This type of research IS a kind of research and development / Research and Development (R & D) with reference to the 4D development model that is (define, design, develop, and disseminate). Data analysis techniques used to process data from the results of the assessment by the validator expert, and the results of the assessment by teachers and learners while testing is limited (12 students of class VIII SMPN 10 Kendari) using quantitative descriptive data analysis techniques disclosed in the distribution of scores on the scale of five categories grading scale that has been determined. The results of due diligence material gain votes validator material in the category of “very good” and “good”, of the data generated in the feasibility test presentation obtained the category of “good” and “excellent”, from the data generated in the feasibility of graphic test obtained the category of “very good “and” good “, as well as of the data generated in the test the feasibility of using words and language obtained the category of“very good “and” good “, so with qualifications gained the teaching materials IPA integrated type webbed by applying discourse analysis on the theme of energy and food for Junior High School (SMP) grade VIII suitable as teaching materials. In limited testing, data generated in response to a science teacher at SMPN 10 Kendari to product instructional materials as “excellent”, and from the data generated while testing is limited by the 12 students of class VIII SMPN 10 Kendari are more students who score indicates category “very good”, so that the qualification obtained by the natural science (IPA) teaching material integrated type webbed by applying discourse analysis on the theme of energy and food for SMP / class VIII fit for use as teaching material.

Imitative Tactics in Pedro de Padilla’s Églogas pastoriles: the Ovidian Mark

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Soledad Pérez-Abadín Barro

2017-11-01

Full Text Available Pedro de Padilla’s Églogas pastoriles, bucolic book of virgilian extraction, diversify its configuration through the exercise of an eclectic imitatio, that canalizes the adoption of models foreign to pastoral tradition, amongst them Ovid, Boccaccio, Petrach, Sannazaro, Garcilaso and Fray Luis de León, incorporated with various imitative tactics. This paper shows the presence of two Ovid’s works, Remedia amoris and Fable of Narcissus (Metamorphoses, III, ls. 339-510, examples of heuristic imitatio, that allows to adapt the source to pastoral background, without disfiguring it. The Remedia amoris are object of a selective treatment, to be added as a marginal element to Silvano’ story. The Fable of Narcissus develops the ovidian myth, intermediated by the Alamanni’s Italian version, that also heads the Hernando de Acuña and Gregorio Silvestre’s recreations.

El cine en el cine: Los abrazos rotos (Pedro Almodóvar, 2009

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Pedro Poyato

2012-10-01

Full Text Available El cine en el cine, tema recurrente en la filmografía de Pedro Almodóvar, protagoniza también Los abrazos rotos, película que contiene en su interior otra titulada Chicas y maletas. Pero las imágenes de esta segunda película, trasunto de otra anterior del propio Almodóvar, Mujeres al borde un ataque de nervios, coexisten con las de un documental sobre su rodaje. El resultado es una proliferación de imágenes segundas que, incorporadas según una estructura en abismo, el filme va a conjugar de múltiples y variadas maneras. El presente trabajo trata de dar cuenta de la génesis, funcionamiento y declinación de estas imágenes segundas y de los sentidos que de ello emanan.

A propósito de los orígenes de don Pedro, obispo de Osma (1101-1109

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Juan Pablo Rubio Sadia

2007-01-01

Full Text Available La procedencia del obispo francés Pedro de Osma (1101-1109, el primero tras la restauración diocesana, ha sido objeto de muy diversas consideraciones. De hecho, aparece citado como oriundo de Bourges, pero también de Béziers, como monje cluniacense de Auch, pero al mismo tiempo de Aurillac y de Sahagún. En estas páginas vamos a valorar de forma crítica la base documental existente detrás de cada una de estas aserciones en vistas a esclarecer, en el mayor grado posible, cuál es el verdadero origen (la ciudad y el supuesto monasterio de profesión del santo patrono de la Iglesia oxomense y dónde se hallan los límites entre la creencia tradicional y el dato documentado.The origin of the French bishop Pedro de Osma (1101-1109, the first one after the diocesan restoration, has been the object of very diverse considerations. In fact, he appears mentioned as native of Bourges, but also of Béziers, as a Cluniac monk of Auch, and at the same time of Aurillac and Sahagún. In these pages we are going to assess in a critical way, the existing documentary base behind each one of these assertions in order to clarify, as much as possible, which is the true origin (the city and the supposed monastery of profession of the Oxonian Church Patron Saint, and where are the limits between the traditional belief and the documented data.

UM OLHAR SOBRE OS CONFLITOS NO AMBIENTE ORGANIZACIONAL: entrevista com Dr. Pedro Fernando Santos Silva da Cunha.

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Kamille Ramos Torres

2017-01-01

Full Text Available Nessa edição, a Revista Foco, por meio de Kamille Ramos Torres, traz uma entrevista com o Dr. Pedro Fernando Santos Silva da Cunha, professor associado com agregação da Universidade Fernando Pessoa em Portugal. Suas pesquisas versam sobre a Gestão de Conflitos, Negociação, Mediação, Paz, entre outros. Nessa entrevista, ele expõe sua trajetória profissional e acadêmica, e nos fornece um pouco do seu imenso conhecimento sobre a Mediação de Conflitos no ambiente organizacional.

ALFONSO X EL SABIO, General Estoria, VI partes (tomos I-X, Pedro SÁNCHEZ-PRIETO (coord.,

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Irene SALVO GARCÍA

2010-06-01

Full Text Available La General Estoria compuesta en el taller historiográfico de Alfonso X (1221-1284 se publica íntegra por primera vez gracias a esta edición dirigida por Pedro Sánchez-Prieto y patrocinada por la Biblioteca Castro. Por las características intrínsecas de la obra y por la calidad y rigurosidad editorial esta publicación supone un acontecimiento de importantísimas consecuencias para las letras castellanas medievales que hasta ahora se encontraban incompletas sin la edición íntegra de la obra alf...

Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

OpenAIRE

Siner, Joshua I.; Samelson-Jones, Benjamin J.; Crudele, Julie M.; French, Robert A.; Lee, Benjamin J.; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Nichols, Timothy C.; Camire, Rodney M.; Arruda, Valder R.

2016-01-01

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-domain–deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by fu...

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN PEMETAAN PIKIRAN (MIND MAPPING TERHADAP KEMAMPUAN MENULIS TEKS BERITA SISWA KELAS VIII SMP NEGERI 1 PANTI

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Ricci Gemarni Tatalia, M.Pd

2017-05-01

Full Text Available This study was generated from the problem of students’ ability in writing news texts ini class VIII, SMPN 1 Panti. Some of the problem were (1 lack of the students’ response towards news writing teaching and learning process, (2 lack of teacher’s creativity in designing interesting news sriting learning model, (3 no appropriate creative techniques applied by the teacher which could train the students to develop their skill in writing news texts and (4 lack of the students’ motivation in participating in teaching and learning process because of their lack of understanding in the elements of news. Thus, this study was aimed at escribing the effect of the students’ ability ini writing news texts in class VIII SMP N 1 Panti. This was a quantitative research with factorial 2x2 experimental design. The population was the students in class VIII SMPN 1 Panti. Sampling technique was done by using random sampling and the data was collected through test. The result of the study revealed that cooperative learning model with STAD mind mapping type affected the students’ ability in writing news texts

Mechanical conceptual design of 6.5 meter telescope: Telescopio San Pedro Mártir (TSPM)

Science.gov (United States)

Uribe, Jorge; Bringas, Vicente; Reyes, Noe; Tovar, Carlos; López, Aldo; Caballero, Xóchitl; Martínez, César; Toledo, Gengis; Lee, William; Carramiñana, Alberto; González, Jesús; Richer, Michael; Sánchez, Beatriz; Lucero, Diana; Manuel, Rogelio; Rubio, Saúl; González, Germán.; Hernández, Obed; Segura, José; Macias, Eduardo; García, Mary; Lazaro, José; Rosales, Fabián.; del Llano, Luis

2016-07-01

Telescopio San Pedro Mártir (TSPM) project intends to build a 6.5 meters telescope with alt-azimuth design, currently at the conceptual design. The project is an association between Instituto de Astronomía de la Universidad Nacional Autónoma de México (IA-UNAM) and the Instituto Nacional de Astrofísica, Óptica Electrónica (INAOE) in partnership with department of Astronomy and Steward Observatory of University of Arizona and Smithsonian Astrophysical Observatory of Harvard University. Conceptual design of the telescope is lead and developed by the Centro de Ingeniería y Desarrollo Industrial (CIDESI). An overview of the feasibility study and the structural conceptual design are summarized in this paper. The telescope concept is based on telescopes already commissioned such as MMT and the Baade and Clay Magellan telescopes, building up on these proven concepts. The main differences relative to the Magellan pair are; the elevation axis is located 1 meter above the primary mirror vertex, allowing for a similar field of view at the Cassegrain and both Nasmyth focal stations; instead of using a vane ends to position the secondary mirror TSPM considers an Steward platform like MMT; finally TSPM has a larger floor distance to m1 cell than Magellans and MMT. Initially TSPM will operate with an f/5 Cassegrain station, but the design considers further Nasmyth configurations from a Cassegrain f/5 up to a Gregorian f/11. The telescope design includes 7 focal stations: 1 Cassegrain; 2 Nasmyth; and 4 folded-Cassegrain. The telescope will be designed and manufactured in Mexico, will be design in Queretaro by CIDESI and built between Queretaro and Michoacán manufacturing facilities; it will be preassembled in these facilities and disassembled to send it to the San Pedro Mártir Observatory for final integration. The azimuth and altitude structure is planned to be constructed in modules and transported by truck and shipped to Ensenada and finally to the OAN where is going

EFEITO DE INJÚRIAS MECÂNICAS NA FIRMEZA E COLORAÇÃO DE GOIABAS DAS CULTIVARES PALUMA E PEDRO SATO

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MATTIUZ BEN-HUR

2001-01-01

Full Text Available O objetivo deste trabalho foi avaliar o efeito das injúrias mecânicas por impacto, compressão ou corte na firmeza e coloração de goiabas 'Paluma' e 'Pedro Sato', colhidas no estádio de maturação "de vez" e armazenadas sob condições de ambiente. Na injúria por impacto, os frutos foram deixados cair, em queda livre, de uma altura de 1,20 m, sofrendo dois impactos, em lados opostos da porção equatorial do fruto. Na injúria por compressão, os frutos foram submetidos a um peso de 3 kg, por 15 minutos. Para a injúria por corte, foram efetuados dois cortes, no sentido longitudinal dos frutos, de exatamente 30 mm de comprimento por 2 mm de profundidade. Os frutos injuriados foram colocados em bandejas de isopor e armazenados sob condições de ambiente (23,4±1 °C, 62±6 % UR. A firmeza dos frutos submetidos ao impacto e compressão foi calculada pela relação peso(N/área injuriada (m2. A evolução da coloração foi feita através de leituras diárias em reflectômetro Minolta CR 200b, procurando comparar a coloração da área lesionada com a da área não lesionada do mesmo fruto. Com relação à injúria por compressão, não se detectou diferença significativa entre as cultivares testadas, mas com relação ao impacto, os frutos da 'Paluma' tiveram uma firmeza significativamente maior que os da 'Pedro Sato'. A área injuriada mostrou maior escurecimento e retardo no amarelecimento, indicado pelo maior ângulo Hue, típico do amadurecimento de goiabas. Os valores de cromaticidade foram sempre inferiores nas áreas injuriadas, de ambas as cultivares, indicando menor síntese de pigmentos carotenóides nessas regiões. Os frutos da 'Pedro Sato' foram caracterizados como mais escuros e mais esverdeados que os da 'Paluma' ao longo do período de armazenamento, independentemente das injúrias.

An immunoradiometric assay for procoagulant factor VIII antigen: results in haemophilia, von Willebrand's disease and fetal plasma and serum

International Nuclear Information System (INIS)

Peake, I.R.; Bloom, A.L.; Giddings, J.C.; Ludlam, C.A.

1979-01-01

An immunoradiometric assay (IRMA) has been developed based on the inhibitor which arose in a polytransfused severe haemophiliac. The two-site IRMA measured antigens closely associated with the procoagulant parts of the factor VIII complex, which are termed FVIIIC antigens or FVIIICAG. FVIIICAG was present in normal plasma and also, at a slightly lower concentration, in normal serum. In 37 patients with haemophilia A, 36 had FVIIICAG levels of less than 10% of the normal plasma pool. In patients with von Willebrand's disease the levels of FVIIIC and FVIIICAG were in good agreement, both before and after treatment with cryoprecipitate or DDAVP. FVIIICAG was relatively stable in plasma at 37 0 C and could also be detected in cord and fetal serum. The assay is of potential value for detecting reduced levels of factor VIII, for carrier detection and for the prenatal diagnosis of haemophilia. (author)

Estudo da articulação temporomandibular em camundongos deficientes de fator VIII

OpenAIRE

Patricia do Socorro Queiroz Feio

2010-01-01

Resumo: A hemofilia é uma doença hemorrágica hereditária ligada ao cromossomo X, decorrente da ausência ou da baixa quantidade no plasma dos fatores de coagulação Fator VIII (hemofilia A) ou do Fator IX (hemofilia B). Clinicamente, a hemofilia se caracteriza por episódios recorrentes de sangramentos profundos, que podem ocorrer espontaneamente ou em decorrência de traumatismos. O sistema músculo-esquelético é freqüentemente afetado pelos eventos hemorrágicos nos pacientes portadores de hemofi...

EFFECT OF INFORMATION SERVICES USING THE MEDIA FILM TO SELF-CONFIDENCE STUDENT OF CLASS VIII SMP NEGERI 8 METRO

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MUDAIM MUDAIM

2015-06-01

Full Text Available Abstract: Pessimism and attitudes that consider themselves weak and does not have the ability when facing a problem will make individual impediment in the task of development. Problems confidence that underlies the research are: a Students are less confident in the ability it has, b Students feel pessimistic when faced with an issue, c Student perception subjectively, d Students still do not do the work independently, and e negative minded students with a state-owned. The problems of this study are whether there is an influence of information services using the medium of film to the confidence of eighth-grade students of SMP Negeri 8 Metro. The purpose of this study was to determine whether there is an influence of information services using the medium of film to the self-confidence of students in class VIII SMP Negeri 8 Metro. Subject participant is graders VIII-E total 30 students. Data were collected by questionnaire self-confidence and analyzed the data used is the t-test. The results of this study, shown by the difference in change scores of confidence from the pre-test and post-test of 17.1. Testing the hypothesis obtained calculation results thitung6,036> table = 1.699. The conclusion is that the information services implemented using the film medium can be a positive influence on self-esteem, especially students of class VIII. The advice given is to use the medium of film should be done intensively and more creative by BK teachers in giving information service. Keywords: Confidence, Service Information Using Media Film.

Ucronía y Utopía. Proyecto utópico de Pedro Henríquez Ureña

OpenAIRE

Durán, Diony

2002-01-01

No Ateneu da juventude do México (1909) os escritores buscavam o estudo da cultura grega, o debate filosófico e especulavam sobre o futuro da Hispano-américa, sobretudo sobre o México. O Ateneu, o México, a cultura e revolução mexicana foram centros de aprendizagem e lançamento para jovens escritores, arquitectos, pintores; especialmente para o dominicano Pedro Henriquez Ureña (1884-1946. At the mexican youth Athenaeum (1909), writters developed the study of greek cultur...

Sr and Nd isotopic signature of the high-K calc-alkaline magmatism of the central Ribeira belt: the Sao Pedro Granite in Lumiar, RJ; Assinatura isotopica de Sr e Nd do magmatismo calcio-alcalino de alto-K na Faixa Ribeira central: o exemplo do Granito Sao Pedro em Lumiar, RJ

Energy Technology Data Exchange (ETDEWEB)

Mendes, Julio Cezar; Medeiros, Silvia Regina de; Chaves, Eduardo Amorim, E-mail: julio@geologia.ufrj.br, E-mail: silvia@geologia.ufrj.br, E-mail: edupc2@yahoo.com.br [Departamento de Geologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) (Brazil)

2011-09-15

In the central-northern Ribeira belt there are many granitic to granodioritic bodies showing varied shape and size, characterizing a late- to post-collisional Ca-alkaline, cordilleran I-type province. The Sao Pedro Granite occurs in the mountain region of Rio de Janeiro State as small post-collisional bodies. It presents isotropic fabric, equigranular to seriate inequigranular texture, as well as local concentration of allanite, which gives discrete composition and texture variation to the rock. The granite has a high-K calcalkaline to alkali-calcic character and weakly peraluminous nature. Despite its short geochemical variation, high Ba, Zr and Th contents besides low concentrations of MgO and CaO are noticeable. High REE contents are associated with fractionated REE patterns showing strong negative Eu anomalies. A crustal origin for the granite can be assumed by its very negative and positive .Nd and .Sr values, respectively, as well as by 87Sr/86Sr initial ratios ranging from 0,718 to 0,740. TDM ages point to paleoproterozoic source, which agrees with geological time of intensive crust generation. (author)

75 FR 36426 - Legislative Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public...

Science.gov (United States)

2010-06-25

... Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public Health Service Act....) 111-148. Section 5202 of the ACA changes the Nursing Student Loan (NSL) program by: (1) Increasing the... degree in nursing. Below are details on how the ACA changes Sections 836(a), 836(b)(1), and 836(b)(3) of...

Modifications to LLNL Plutonium Packaging Systems (PuPS) to achieve ASME VIII UW-13.2(d) Requirements for the DOE Standard 3013-00 Outer Can Weld

International Nuclear Information System (INIS)

Riley, D; Dodson, K

2001-01-01

The Lawrence Livermore National Laboratory (LLNL) Plutonium Packaging System (PuPS) prepares packages to meet the DOE Standard 3013 (Reference 1). The PuPS equipment was supplied by the British Nuclear Fuels Limited (BNFL). The DOE Standard 3013 requires that the welding of the Outer Can meets ASME Section VIII Division 1 (Reference 2). ASME Section VIII references to ASME Section IX (Reference 3) for most of the welding requirements, but UW-13.2 (d) of Section VIII requires a certain depth and width of the weld. In this document the UW-13.2(d) requirement is described as the (a+b)/2t s ratio. This ratio has to be greater than or equal to one to meet the requirements of UW-13.2(d). The Outer Can welds had not been meeting this requirement. Three methods are being followed to resolve this issue: (1) Modify the welding parameters to achieve the requirement, (2) Submit a weld case to ASME that changes the UW-13.2(d) requirement for their review and approval, and (3) Change the requirements in the DOE-STD-3013. Each of these methods are being pursued. This report addresses how the first method was addressed for the LLNL PuPS. The experimental work involved adjusting the Outer Can rotational speed and the power applied to the can. These adjustments resulted in being able to achieve the ASME VIII, UW-13.2(d) requirement

Mapping and analysis of the assignment concepts process at academic secretaries of Colegio Pedro II: reflections and proposals for improvement

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Patrícia Bitencourt de Carvalho Athaydes

2016-12-01

Full Text Available The Colegio Pedro II was equated to Federal Institutes of Education, Science and Technology by Law 12677 Publication of June 25, 2012. If, on the one hand, this equalization resulted in an expressive organizational restructuring, with growth of the number of educational units, in addition to the incorporation of new educational levels, on the other, this institutional growth was dissociated from efforts of standardization of administrative processes, notably, under the academic departments of different units – where it shows a variation of the process of launching notes/concepts. In order to contribute with improvements to the operation of the institution, the present article aims to map and analyse comparatively the launch process of notes/concepts in three campus of the Colegio Pedro II. Methodologically, are held in-person interviews with professionals responsible for the academic departments of the following units, Engenho Novo I, Humaita I and Realengo I, in order to obtain the necessary subsidies to support the design of the processes performed by these academic departments units. As a result, it can be verified that the processes of the academic departments are not aligned to any system of performance indicators, which motivated the proposal of a standard process for the launching of notes/concepts, as well as a performance indicators panel (KPIs.

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR POKOK BAHASAN PASAR DENGAN METODE RESITASI PADA SISWA KELAS VIII SMP NEGERI 24 SEMARANG TAHUN AJARAN 2013/2014

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Diinul Qoyyimah

2013-11-01

Full Text Available Aktivitas siswa kelas VIII pada mata pelajaran ekonomi SMP Negeri 24 Semarang pada pokok bahasan pasar masih rendah sehingga berdampak pada hasil belajar siswa yang masih dibawah KKM. Salah satu penyebabnya karena guru masih menerapkan metode belajar yang sama dalam waktu yang lama sehingga mengakibatkan rendahnya perolehan hasil belajar. Melalui penerapan metode ceramah bervariasi dan resitasi diharapkan siswa dapat belajar dengan santai dan senang dalam mengikuti proses pembelajaran. Penelitian ini bertujuan untuk mengetahui penerapan metode resitasi, dapat meningkatkan aktivitas dan hasil belajar siswa. Metode penelitian menggunakan penelitian tindakan kelas. Prosedur penelitian dilakukan dimulai dengan perencanaan, pelaksanaan, observasi dan refleksi. Metode pengumpulan data dengan dokumentasi dan tes. Hasil penelitian menyatakan bahwa ada peningkatan aktivitas siswa dan hasil belajar siswa materi pasar pada kelas VIII SMP Negeri 24 Semarang tahun 2013/2014. The students’ activity in VIII class of economic subject in SMP Negeri 24 Semarang in the subject matter of market topic is still low so it has the impact on the students’ learning outcome which is still under KKM requirements. One of the causes is because the teachers are still apply the same learning method in a long time so it resulted in low learning outcomes acquisition.through the application of various conventional methods and recitation are expected that students can learn easily and pleasure in participating of learning process. This study aims to determine the application of recitation method which can improve the activity and students’ learning outcomes. The research method using classroom action research. The research procedure begins with planning, implementation, observation and reflection. Methods of data collection carried out by documentation and test. The result of research states that there is an increasing activity and students’ learning outcomes in the

O arranjo arquivístico como escrita: uma reflexão sobre a narrativa em imagens a partir do Fundo Pedro Miranda no Arquivo Público e Histórico de Ribeirão Preto

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Eduardo Ismael Murguia

Full Text Available Reflete sobre algumas questões importantes para o arranjo de fotografias em arquivos. Considera-se aqui o arranjo arquivístico um ato de comunicação e, como tal, se estrutura através do enunciado narrativo da vida e obra de José Pedro Miranda, intelectual e historiador que na segunda metade do século XX produziu e acumulou vasta documentação sobre Ribeirão Preto, em especial um número significativo de fotografias. E através deste propõe-se analisar a narrativa circunscrita no âmbito das fotografias coletadas por José Pedro Miranda. Para tanto se discute o estatuto documental da fotografia, destacando que em um ambiente de arquivo a fotografia adquire significado na série além da unidade, e que portanto, os conjuntos fotográficos construídos por José Pedro Miranda tornam-se expressão e materialidade de sua compreensão e produção intelectual. Interpretações sobre a construção de bibliotecas como narrativas são utilizadas como alusão a uma possibilidade de entendimento dos arquivos pessoais.

Design local exhaust ventilation on sieve machine at PT.Perkebunan Nusantara VIII Ciater using design for assembly (DFA) approach with Boothroyd and Dewhurst method

Science.gov (United States)

Khalqihi, K. I.; Rahayu, M.; Rendra, M.

2017-12-01

PT Perkebunan Nusantara VIII Ciater is a company produced black tea orthodox more or less 4 tons every day. At the production section, PT Perkebunan Nusantara VIII will use local exhaust ventilation specially at sortation area on sieve machine. To maintain the quality of the black tea orthodox, all machine must be scheduled for maintenance every once a month and takes time 2 hours in workhours, with additional local exhaust ventilation, it will increase time for maintenance process, if maintenance takes time more than 2 hours it will caused production process delayed. To support maintenance process in PT Perkebunan Nusantara VIII Ciater, designing local exhaust ventilation using design for assembly approach with Boothroyd and Dewhurst method, design for assembly approach is choosen to simplify maintenance process which required assembly process. There are 2 LEV designs for this research. Design 1 with 94 components, assembly time 647.88 seconds and assembly efficiency level 23.62%. Design 2 with 82 components, assembly time 567.84 seconds and assembly efficiency level 24.83%. Design 2 is choosen for this research based on DFA goals, minimum total part that use, optimization assembly time, and assembly efficiency level.

Construindo Vera Cruz e desconstruindo gênero: aproximações entre Pedro Almodóvar e Judith Butler

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Carla Rodrigues

Full Text Available Este artigo aproxima as proposições de desconstrução da distinção sexo/gênero tal qual proposta por Judith Butler com as questões apresentadas no filme A pele que habito, do cineasta Pedro Almodóvar. Neste diálogo, o trabalho debate questões como o diagnóstico de disforia de gênero e o problema da essencialização das categorias feminino/masculino e sua binaridade, a partir dos quais tematiza a normatividade de gênero e a autonomia do sujeito diante das normas.

Historical figures at the office of Endocrinology.

Science.gov (United States)

Alfaro-Martínez, José J

2014-01-01

Some historical figures have suffered endocrine diseases. This review relates those whose diseases have been published in the scientific literature. It takes a biographical summary and describes the disease process in those considered most relevant by the nature of the disease or the importance of the figure in the Spanish and Latin American context: the Pharaoh Akhenaten, Maximinus I, Bodhidharma, Sancho I of Leon, William the Conqueror, Enrique IV of Castile, Henry VIII, Mary Tudor, Carlos II of Spain, Pio Pico, Pedro II of Brazil, Eisenhower and J. F. Kennedy. Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.

Pengembangan Perangkat Pembelajaran Matematika Berbasis Problem Based Learning (PBL untuk Meningkatkan Kemampuan Pemecahan Masalah Peserta Didik Kelas VIII

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Rizza Yustianingsih

2017-09-01

Full Text Available Abstrak. Berdasarkan hasil penelitian pendahuluan pada kelas VIII SMP di lapangan, masih ditemukan kemampuan pemecahan masalah matematis siswa dalam masalah nyata yang belum optimal dan aktivitas siswa tidak mendukung proses belajar mereka. Salah satu faktornya adalah tidak cocoknya perangkat pembelajaran yang dapat memudahkan pembelajar untuk memperbaiki pemecahan kemampuan matematika dan kemampuan belajar siswa. Dari situ, untuk mendasari melakukan pengembangan perangkat pembelajaran matematika, ada rencana rencana pembelajaran (RPP dan lembar kerja siswa (LKPD berbasis Problem Based Learning (PBL, yang dapat memberikan pengalaman belajar untuk belajar pemecahan masalah dan dapat memberikan efek potensial yang baik pada aktivitas siswa selama proses belajar. Data dikumpulkan melalui observasi, kuesioner, wawancara, dan uji kemampuan pemecahan masalah. Subyek penelitian ini adalah siswa kelas VIII SMP N 3 Sawahlunto. Pengembangan penelitian ini yang digunakan adalah mode Plomp yang terdiri dari tahap awal penelitian, tahap prototipe, dan tahap penilaian. Berdasarkan hasil analisis data, terlihat bahwa alat pembelajaran berdasarkan PBL telah memenuhi kriteria yang valid dalam hal isi dan konstruksi. Peralatan pelajaran telah dianggap praktis dalam hal pelaksanaan dan efisiensi penggunaan waktu oleh guru dan siswa. Alat pelajaran juga efektif dalam hal proses penguasaan presentasi siswa belajar setelah menggunakan pembelajaran berbasis perangkat berbasis pembelajaran lebih besar dari atau sama dengan 75% sedangkan dalam hal hasil rata-rata siswa telah aktif dalam belajar. Kata kunci: Perangkat Pelajaran Matematika, Pemecahan Masalah, PBL.   Abstract. Based on the results of preliminary studies at grade VIII SMP in the field, it is still  found a mathematical problem solving ability of students in real problem who have not optimally and students activities do not support their learning process. One of the  factor is unsuitable of learning tools

Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A

NARCIS (Netherlands)

Collins, P. W.; Blanchette, V. S.; Fischer, K.; Bjorkman, S.; Oh, M.; Fritsch, S.; Schroth, P.; Spotts, G.; Astermark, J.; Ewenstein, B.

Background: The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level <1 IU dL(-1).

Documentación del fondo de Oseira (AHN relacionada con el monasterio San Pedro de Vilanova de Dozón (1015-1295

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Romaní Martínez, Miguel

2003-12-01

Full Text Available After the introduction and the criteria for transcription, we publish 25 documents of the 11>sub>th 12_th and 13thcenturies belonging to the collection of Oseira at the AHN related to the monastery of San Pedro de Vilanova de Dozon, in Tierra de Deza (Pontevedra. The suggested periods make it possible to observe the transition from the Visigothic writing to the Carolingian. We also include an appendix with tables of diplomatic and paléographie analyses, a sample of the most representative writings, onomastic and toponymie indices, and a bibliography.

Tras la introducción y criterios de transcripción, se editan 25 documentos de los siglos XI, XII y XIII pertenecientes al fondo de Oseira del AHN relacionados con el monasterio de San Pedro de Vilanova de Dozón, en Tierra de Deza (Pontevedra. Las fechas propuestas permiten observar el paso de la escritura visigótica a la Carolina. Se incluye un apéndice con tablas de análisis diplomático y paleográfico, una muestra de las escrituras más representativas, índices onomástico y toponímico, y bibliografía.

De um escritor escrevente: “O amor de Pedro por João”

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Maria Iraci Cardoso Tuzzin

2017-03-01

Full Text Available O romance O amor de Pedro por João publicado no Brasil, em 1982, e escrito durante o exílio do escritor brasileiro Tabajara Ruas (1942 é analisado a partir da relação escritor/escrita. Tal correspondência é discutida por um viés que inclui as anotações de pesquisadores, como Avelar, Silverman e Santiago, entre outros. A observação da forma, do estilo e das temáticas empregadas pelo artista aponta para a complexidade de questões referentes à profissão “escritor” em um contexto histórico pleno de cerceamento de liberdades situado entre os anos 1960 e 1980. Além disso, suscita reflexões sobre procedimentos literários experimentais em um meio social em que se ampliaram o grau e o controle da informação, apontando, deste modo, ligações entre a Literatura e a História.

The status of experience in the theory of knowledge of Pedro Figari

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Gabriela Ferreira Olaso

2016-02-01

Full Text Available In this paper we inquire about the status of experience in the theory of knowledge of Pedro Figari (Uruguayan artist, philosopher and educator of the 20th Century to answer how his philosophy - of a monist characterization - influences his pedagogy - of an active orientation-. His monist, unicist or holistic construction, is the key to overcome the antagonism of dualistic positions and the mechanicism as a model for the dynamic of the being and the matter. His emblematic phrase, to work thinking  and to think  working, acts directly against what the dualism support, the mind-body separation, expressed and inscribed by Descartes as the pillars of the Enlightenment and the modernity, that is, establishing the division between episteme and doxa, the techné and the alienated action, factory-made. Arguments will be given to stay that the intervention of Figari´s philosophy and metaphysics, elaborated in his pedagogical thinking, is able to respond to issues that transcends their time, relevant to the current social reality.

Mejora de los procesos de beneficio y extracción de minerales auroargentíferos del asentamiento minero de San Pedro Frío, Colombia

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Yáñez Traslaviña, J. J.

2005-04-01

Full Text Available The San Pedro Frio district mining, Colombia, is a rich region producing gold-silver ores. Nowadays, the extraction processes used are amalgamation, percolation cyanidation and precipitation with zinc wood. Due to the ignorance of the ore characteristics, gold and silver treatment processes are inadequate and not efficient In addition the inappropriate use of mercury and cyanide cause environmental contamination. In this research the ore characterization was carried out obtaining fundamental parameters for the technical selection of more efficient gold and silver extraction processes. Experimental work was addressed to the study of both processes the agitation cyanidation and the adsorption on activated carbon in pulp. As a final result proposed a flowsheet to improve the precious metals recovery and reduce the environment contamination.

El asentamiento minero San Pedro Frío, Colombia, es una región rica en minerales auroargentíferos. Actualmente, los mineros de la región emplean procesos de tratamiento como amalgamación, cianuración por percolación y precipitación con viruta de zinc. Debido al desconocimiento de las características del mineral que allí se explota, los procesos de beneficio y tratamiento de oro y plata resultan inadecuados y poco eficientes, ocasionando, además, contaminación ambiental por el uso inapropiado del mercurio y cianuro. En este trabajo se realizó la caracterización del mineral obteniéndose parámetros fundamentales para la selección técnica de los procesos de extracción y recuperación de oro y de plata. El trabajo experimental se orientó al estudio de los procesos de cianuración por agitación y de adsorción con carbón activado en pulpa. Como resultado final, se presentó una propuesta de tratamiento para mejorar la recuperación de los metales preciosos y disminuir los niveles de contaminación ambiental

Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment

Science.gov (United States)

The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

Infrared studies of H II regions: the Sharpless regions S148, 184, 198, 206 and 269

International Nuclear Information System (INIS)

Pismis, Paris

1991-01-01

We present the results of a combined near-infrared and IRAS mapping study of five H II regions for which fairly complete information at optical and radio wavelengths previously existed. The near-infrared observations, carried out with the 2.1-m telescope at Observatorio de San Pedro Martir (Mexico), allowed us to study the the stellar content at the core of each nebula, while an analysis of extended near-infrared emission zones showed these to arise mainly from ionized gas (S148 and S206) or through scattering and thermal emission from dust grains surrounding a massive young star (S269-IRS2). The analysis of IRAS data, on the other hand, suggests that two different populations of grains contribute to the observed 12- to 100-μm fluxes. (author)

MOVIMENTOS DE MASSA NA BACIA DO RIO SÃO PEDRO, MUNICÍPIO DE NOVA FRIBURGO, ASSOCIADO AO EVENTO DE JANEIRO DE 2011 (Mass movement of the San Pedro river basin, the city of Nova Friburgo, associated with the event of january 2011)

OpenAIRE

SOUZA, Juliana Martins; ASEVEDO, Lorena Abreu; SOARES, Isabel Linhares Pereira; BERTOLINO, Ana Valéria Freire Allemão

2012-01-01

Os movimentos de massa são fenômenos naturais que interferem na evolução das formas de relevo e provocam danos de ordens sociais, físicas e econômicas. O objetivo central do trabalho é identificar as tipologias de movimentos de massa que ocorreram em janeiro de 2011, na bacia do rio São Pedro – município de Nova Friburgo, correlacionando com os tipos de cobertura vegetal, a frequência e intensidade das chuvas. Os pontos de movimentos de massa foram georreferenciados através do GPS de alta pre...

Geodinámica ambiental de La cuenca Del río San Pedro. Flanco norandino venezolano

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Kati A. MONTIEL

2001-12-01

Full Text Available El estúdio abarca el perímetro de Ia cuenca del rio San Pedro, flanco norandino venezolano, donde amplias áreas deforestadas, cicatrices de deslizamiento, sistemas de diaclasas, cercavas y surcos se conjugan y generan un desequilíbrio morfogenético expresado en movimientos de masa generalizados y avalanchas torrenciales, representando un peligro natural para Ia población local. Mediante el diserto de un SIG se efectuo una matriz espacial sustentada en el análisis geológico, geomorfológico, geotécnico, fotointerpretativo y ajustado a Ia clasificación de Ferrer, se identificaron diferentes niveles de estabilidad relativa: inestabilidad, inestabilidad crítica y potencialmente inestable, estos localizados en los espacios de mayor concentración poblacional.

“May the infinity be without stars”: The becoming diva in the performance of Pedro Lemebel

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María Pilar Jarpa Manzur

2018-02-01

Full Text Available Within the practices of subversion that are promoted in the performance of Pedro Lemebel, a ritualized use of the figuration of some Latin American divas of the middle of the XX century persists. At the time of deconstructing the homophobic discourse of the Chilean civic-military dictatorship, Lemebel traces from her reappropriations not only a becoming woman but a becoming diva, which, among its various dimensions, in-corporates differences of gender, sex, ethnicity, language, claiming a diversity of challenging bodies. The complicity that can be seen with these figurations of the feminine, opens an attractive field of analysis to explore common places and suggestive vanishing points, where they are mobilized as references of old and future irreverence.

The model of television in Pedro Almodóvar. Cinema vs. Televisión

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Agustín GÓMEZ GÓMEZ

2014-10-01

Full Text Available In this paper we analyze the TV model presented by Pedro Almodóvar in his filmography. Of the eighteen movies, but three, all contain, one way or another, a reference to TV in a critical sense. Through the analysis of all his films, we observe the way in which TV appears and focus on four models or functions of the TV in his work. The first one has to do with the viewing mode, which we have named “domestic model”. A second function, which we will call “realistic”, is one which means that only what appears on screen exists, but Almodóvar desecrates reality through parody. A third model is a critique of so-called junk televisión. Finally, a fourth function is the presence of other films through the TV screen to establish an intertextual relationship with a narrative purpose.

Characterization of auriferous ores from the mining zone of San Pedro Frio (Bolivar-Colombia) to selection the extractive processes

International Nuclear Information System (INIS)

Yanez Traslavina, J J; Garcia Paez, I H; Pedraza Rosas, J E; Laverde Catano, D

2005-01-01

The benefit and treatment process of auriferous minerals that actuality are apply in San Pedro Frio's Miner Place, this carry a slightly efficient systems with percentages of gold recovery not bigger than 40 %. The present work is the summary of the results of analysis and characterization of minerals auriferous of the above mentioned mining zone. With this article, one tries to stimulate the miners to realize a development reconciled with the university, since according to the results obtained during this research, it is possible to achieve percentages of gold dissolution of up to 85 % for the minerals of San Pedro Frio. This affirmation was possible to propose it, by means of the analyses of the characterization of the mineral. By means of the physicochemical characterization of the mineral, there was possible the estimation of certain conditions of the metallurgical processes involved in a possible plant of treatment, it is so the percentage of solid more adapted for the managing of the solid ones in flesh was 40 % in weight, the high quantity of clay minerals they might impede the processes of separation solidly -liquid, among others operative specifications according to the mineralogical and metallurgical characterization, the average size of the present gold in the mineral, one finds to a minor grain 75 μm, this indicates that the cyanidation process for agitation would turn out to be the most suitable. The answer of the leaching diagnosis, they assumed very satisfactory results, since 94 % of the gold in the samples is as free gold, which will be able to affect in cyanidation short times

[São Pedro de Alcântara Charity Hospital: assistance and healthcare in Goiás during the nineteenth century].

Science.gov (United States)

De Magalhães, Sônia Maria

2004-01-01

A lay institution founded in the city of Goiás in 1825, the São Pedro de Alcântara Charity Hospital was fruit of an initiative by an influential local group that recognized a social evil: the lack of assistance for the destitute and ill. Within the realm of social assistance, the hospital adopted charitable Christian roles and principles, providing aid to the mentally ill, the imprisoned, and the infirm and needy in general. After inauguration of the public cemetery, it also buried indigents at no cost.

Pedro Calderón de la Barca, Judas Macabeo. Edición crítica de las dos versiones, ed. F. Rodríguez-Gallego

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Fernando Plata

2013-10-01

Full Text Available Review of Pedro Calderón de la Barca, Judas Macabeo. Edición crítica de las dos versiones, ed. F. Rodríguez-Gallego, Universidad de Navarra / Iberoamericana / Vervuert (Biblioteca Áurea Hispánica, 80; Comedias Completas de Calderón, 8, Madrid / Frankfurt, 2012, 501 pp. ISBN: 978-84-8489-692-0.

Energies and lifetimes of excited states in copperlike Kr VIII

International Nuclear Information System (INIS)

Livingston, A.E.; Curtis, L.J.; Schectman, R.M.; Berry, H.G.

1980-01-01

The spectrum of Kr VIII has been observed between 180 and 2000 A by using foil excitation of 2.5--3.5-MeV krypton ions. Twenty new transitions have been classified and eleven new excited-state energies have been determined within the n=4 --7 shells. The ionization potential is derived to be 1 015 800 +- 200 cm -1 . The excited-state energies and fine structures are compared with recent relativistic Hartree-Fock calculations. The 4p-state lifetime has been measured by performing a simultaneous analysis of decay data for the 4p level and for its dominant cascade-repopulating levels. The 4p lifetime is found to be 30% shorter than previously measured values and is in excellent agreement with the result of a recent multiconfiguration Hartree-Fock calculation. The source of the discrepancy between this result and earlier measurements is discussed

Descripción de un inmunoensayo enzimático que reconoce anticuerpos anti-factor VIII/von Willebrand obtenidos a partir de hibridomas múridos Description of an enzime immunoassay that recognizes anti-factor VIII/von Willebrand antibodies obtained from murine hybridomas

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Renée González Sampedro

1999-04-01

Full Text Available Se describe un inmunoensayo enzimático (ELISA que detecta anticuerpos anti-Factor-VIII/von Willebrand (FVIII/vW, con una relación de enlace > 5, que permite reconocer dichos anticuerpos tempranamente en los cultivos de hibridomas múridos. Para la adsorción de las placas del inmunoensayo se utilizaron preparados semipurificados de FVIII/vW obtenidos en Cuba. Se inmunizaron ratones Balb/c con la finalidad de generar los anticuerpos monoclonales detectados por este ELISA. Se obtuvo un clon con crecimiento estable y varios subclones positivos por el ELISA con actividad biológica específica de anticuerpos inhibidores de FVIIIAn enzime immunoassay (ELISA that detects anti-Factor VIII/von Willebrand (FVIII/vw antibodies with a binding relationship > 5 that allows the early recognition of such antibodies in the cultures of murine hybridomas is described. Semipurified preparations of FVIII/vw obtained in Cuba were used for the adsorption of the immunoassay plates. Balb/c mice were immunized in order to generate the monoclonal antibodies detected by this ELISA. A clone with stable growth and several positive subclones were obtained by ELISA with specific biological activity of FVIII-inhibiting antibodies

Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats

International Nuclear Information System (INIS)

Kane, W.H.; Ichinose, A.; Hagen, F.S.; Davie, E.W.

1987-01-01

Human factor V is a high molecular weight plasma glycoprotein that participates as a cofactor in the conversion of prothrombin to thrombin by factor X/sub a/. Prior to its participation in the coagulation cascade, factor V is converted to factor V/sub a/ by thrombin generating a heavy chain and a light chain, and these two chains are held together by calcium ions. A connecting region originally located between the heavy and light chains is liberated during the activation reaction. In a previous study, a cDNA of 2970 nucleotides that codes for the carboxyl-terminal 938 amino acids of factor V was isolated and characterized from a Hep G2 cDNA library. This cDNA has been used to obtain additional clones from Hep G2 and human liver cDNA libraries. Furthermore, a Hep G2 cDNA library prepared with an oligonucleotide from the 5' end of these cDNAs was screened to obtain overlapping cDNA clones that code for the amino-terminal region of the molecule. The composite sequence of these clones spans 6911 nucleotides and is consistent with the size of the factor V message present in Hep G2 cells (approximately 7 kilobases). The cDNA codes for a leader sequence of 28 amino acids and a mature protein of 2196 amino acids. The amino acid sequence predicted from the cDNA was in complete agreement with 139 amino acid residues that were identified by Edman degradation of cyanogen bromide peptides isolated from the heavy chain region and connecting region of plasma factor V. The domain structure of human factor V is similar to that previously reported for human coagulation factor VIII. Two types of tandem repeats (17 and 9 amino acids) have also been identified in the connecting region of factor V. The present data indicate that the amino acid sequence in the heavy and light chain regions of factor V is ∼ 40% identical with the corresponding regions of factor VIII

Report on corrections and future considerations for Appendices II–VIII of the International Code of Nomenclature for Algae, Fungi, and Plants

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For the first time, the main text and Appendices II–VIII of the International Code of Nomenclature were separately published following decisions of the Melbourne Nomenclature Section, which contributed to subsequent development of an online resource capable of producing the Appendices in real time. ...

Pictorial materials used in the polychrome decorations of the façade of the palace of King Pedro I (The Royal Alcazar of Seville, Spain

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López-Cruz, O.

2015-06-01

Full Text Available This research has been conducted on the architectural decoration of the façade of the Palace of King Pedro I (The Royal Alcazar of Seville, Spain. The stratigraphic study of pictorial layers has revealed numerous interventions made on the polychrome decorations that have been related to those referenced in historical documents. Mineralogical and compositional studies of the natural and synthetic pigments and their alteration have provided an independent chronology for the polychrome decorations. Finally, this study has revealed the importance of colour of the decorative elements over the history of the palace.El estudio de la fachada del palacio de Pedro I ha puesto de manifiesto la existencia de un gran número de policromías realizadas con una amplia variedad de pigmentos de diferentes cronologías. Mediante diversas técnicas analíticas han sido diferenciadas y caracterizadas química y mineralógicamente. El estudio estratigráfico detallado de las diferentes policromías ha permitido relacionarlas con las sucesivas intervenciones documentadas, comprobando así la gran importancia que el color ha tenido en todas las épocas o momentos históricos del Palacio.

La Victoria de Pedro Aguirre Cerda: ideas para una renovación urbana sin gentrificación para Santiago./ La Victoria of Pedro Aguirre Cerda: ideas for an urban renewal without gentrification in Santiago.

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Ernesto López

2012-12-01

Full Text Available El modelo de renovación urbana en altura de Santiago, en expansión hacia áreas populares del pericentro, es una forma de acumulación de renta de suelo, con efectos de desplazamiento social, es decir, gentrificación. Sin embargo, el pericentro de Santiago es un espacio donde coexisten amplias necesidades y capacidades de densificación urbana sin desplazamiento. Tomando como caso de estudio el desarrollo urbano histórico y actual de la población La Victoria, en Pedro Aguirre Cerda (PAC, se plantea una investigación enfocada en dos perspectivas: histórica, definiendo este espacio desde la dialéctica entre movimientos sociales urbanos y producción espacial específica; y normativa, como una propuesta espacial que combina aspectos claves de mejoramiento barrial y densificación inclusiva y autosustentable. Se evidencia de esta forma la alta complejidad espacial del pericentro de Santiago de Chile, así como la existencia de alternativas de renovación residencial pericentral que sean social y políticamente inclusivas y de bajo impacto en términos de expulsión./ The model of high-rise urban renewal sprawls towards Santiago de Chile’s inner city. This model can be understood as a form of gentrification based on considerable accumulation of the rent gap, while its externalities generate social displacement and physical dilapidation. Notwithstanding, Santiago’s inner city is also a lived space where both needs and capacities of urban regeneration (without displacement coexist. Focusing on the case of La Victoria población, located in the southern municipality of Pedro Aguirre Cerda (PAC, this article seeks to address the following two topics: historically, the inner city responds to a dialectic of urban social movements and specific spatial production; normatively, as an ongoing research project shows, it is feasible to combine neighbourhood regeneration, urban density increase, and citizen participation. The article substantiates the

PENERAPAN MODEL PEMBELAJARAN BAKULIKAN UNTUK MENINGKATKAN KEMAMPUAN BERSIKAP ILMIAH PADA KONSEP PEMANTULAN CAHAYA KELAS VIII

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N. A. Shofiah

2012-01-01

Full Text Available Penelitian tindakan kelas yang bertujuan untuk meningkatkan kemampuan bersikap ilmiah, telah dilakukan di kelas VIII semester IIpada sub pokok bahasan pemantulan cahaya. Untuk meningkatkan kemampuan bersikap ilmiah diterapkan model pembelajaranbakulikan. Penelitian tindakan kelas ini terdiri dari tiga sikus, dengan masing-masing siklus terdiri dari empat tahapan yaituperencanaan, pelaksanaan, observasi dan refleksi. Data sikap ilmiah siswa diambil dari lembar angket dan lembar observasi. Datahasil belajar kognitif diambil dari evaluasi yang ada di LKS tiap akhir siklus dan data hasil belajar psikomotorik diambil dari lembarobservasi tiap akhir siklus. Hasil penelitian menyatakan bahwa sikap ilmiah siswa mengalami peningkatan walaupun tidaksignifikan. Hasil belajar kognitif dan keterampilan psikomotorik siswa mengalami peningkatan tiap siklus dan mencapai ketuntasanpada siklus III. A classroom action research aimed to improve scientific attitude skill had been done in second semester of grade VIII MTs on thesubtopic light reflection. The 'bakulikan' learning model was chosen for improving the scientific attitude skills of the students. Thisaction research consisted of three cycles, and each cycle has four stages, namely, planning, conducting, observation andreflection. The data obtained through questionnaire and observation sheets. The cognitive achievement drawn from the evaluationon each worksheet at the end of each cycle, and the psychometrics recorded from observation sheet. The study concludes that thescientific attitude skill improved significantly. The achievement on cognitive and psychometrics increase gradually on each cycleand get mastery at the end of the last cycle.Keywords: bakulikan; classroom action research; scientific attitude

Vivência de acadêmicos de enfermagem em Pedro Afonso-Tocantis e a importância da interação ensino-serviço e comunidade

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Thaís Fernandes de OLIVEIRA

2012-12-01

Full Text Available Trata-se de um relato de experiência resultado da participação como voluntária da Operação Capim Dourado do Projeto Rondon, realizado no município de Pedro Afonso-TO. Objetivou-se promover a troca de saberes entre a comunidade, os profissionais de saúde do Município de Pedro Afonso-TO e os acadêmicos de enfermagem. As estratégias utilizadas para a realização das oficinas foram rodas de conversa, oficinas, dramatizações e participação na programação da rádio local. A experiência revelou a necessidade de integrar os conhecimentos dos acadêmicos com a comunidade como meio de crescimento profissional e pessoal de todos os envolvidos. A integração ensino-serviço-comunidade através do trabalho voluntário em realidades diferentes enobrece a formação acadêmica, contribuindo assim para um futuro profissional de excelência

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Science.gov (United States)

Dumont, Jennifer A.; Liu, Tongyao; Low, Susan C.; Zhang, Xin; Kamphaus, George; Sakorafas, Paul; Fraley, Cara; Drager, Douglas; Reidy, Thomas; McCue, Justin; Franck, Helen W. G.; Merricks, Elizabeth P.; Nichols, Timothy C.; Bitonti, Alan J.; Pierce, Glenn F.

2012-01-01

Despite proven benefits, prophylactic treatment for hemophilia A is hampered by the short half-life of factor VIII. A recombinant factor VIII-Fc fusion protein (rFVIIIFc) was constructed to determine the potential for reduced frequency of dosing. rFVIIIFc has an ∼ 2-fold longer half-life than rFVIII in hemophilia A (HemA) mice and dogs. The extension of rFVIIIFc half-life requires interaction of Fc with the neonatal Fc receptor (FcRn). In FcRn knockout mice, the extension of rFVIIIFc half-life is abrogated, and is restored in human FcRn transgenic mice. The Fc fusion has no impact on FVIII-specific activity. rFVIIIFc has comparable acute efficacy as rFVIII in treating tail clip injury in HemA mice, and fully corrects whole blood clotting time (WBCT) in HemA dogs immediately after dosing. Furthermore, consistent with prolonged half-life, rFVIIIFc shows 2-fold longer prophylactic efficacy in protecting HemA mice from tail vein transection bleeding induced 24-48 hours after dosing. In HemA dogs, rFVIIIFc also sustains partial correction of WBCT 1.5- to 2-fold longer than rFVIII. rFVIIIFc was well tolerated in both species. Thus, the rescue of FVIII by Fc fusion to provide prolonged protection presents a novel pathway for FVIII catabolism, and warrants further investigation. PMID:22246033

Changes in color and odorant compounds during oxidative aging of Pedro Ximenez sweet wines.

Science.gov (United States)

Chaves, Margarita; Zea, Luis; Moyano, Lourdes; Medina, Manuel

2007-05-02

Pedro Ximenez sweet wines obtained following the typical criaderas and solera method for sherry wines and subjected to oxidative aging for 0, 1.3, 4.2, 7.0, or 11.5 years were studied in terms of color and aroma fraction by using the CIELab method and gas chromatography, respectively. The parameters defining the CIELab color space (a*, b*, and L*) were subjected to a multiple-range test (p 1 that enriched the wines with fruity, fatty, floral, and balsamic notes during the aging process. The changes in color parameters and active odorants were not linearly related to aging time, being especially marked during the first 1.3 years and then less substantial up to the 7 years, the oldest wines exhibiting sensorial properties markedly departing from all others. For the wines aged over 1.3 years (minimum aging), 2,3-butanedione, linalool, and decanal can be used as reliable fingerprints of the older wines' quality.

EK(b)P Keskkomitee VIII pleenumi stenogramm / tõlk. Mart Arold, tõlk. Jaan Isotamm

Index Scriptorium Estoniae

1999-01-01

EK(b)P Keskkomitee VIII pleenum, 21.-23. märts 1950. Sõnavõtud: N. Karotamm, P. Ponomarenko, I. Käbin, V. Kuusik, A. Jaanus, V. Hiznjakov, E. Ristimägi, I. Suija, H. Ajo, A. Meri, G. Abels, M. Assin, G. Latõshov, Rumjantsev, Müürisepp. Kommenteerinud Viktor Niitsoo. Algus: Akadeemia (1998) nr. 12, lk. 2655-2683 ; Järg nr.2;3;4;5;6;7;8;9;10 lk.415-446;639-670;863-894;1087-1118;1310-1342;1534-1566;1759-1790;2017-2048;2220-2256

Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption.

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Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y

2017-05-01

Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

Transcripción revisada del informe de Pedro de Ayala de 1498 sobre las expediciones inglesas de descubrimiento

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Robles Macías, Luis A.

2014-12-01

Full Text Available The report sent by Pedro de Ayala to the Catholic Monarchs from London in 1498 is one of the main sources on the earliest English expeditions to North America. The history of its deciphering, interpretation and translation is presented and, as none of the transcriptions carried out up to now is found to be entirely satisfactory, a new one is proposed based on a literal deciphering of the document, along with translations into French and English. Furthermore, some particularly difficult parts of the text are discussed in detail that, having been misunderstood in earlier editions of the report, led to probably erroneous conclusions about the biography of John Cabot, the itinerary of his voyage of 1497, and the name of the monk who went with him on his expedition of 1498.El informe enviado por Pedro de Ayala a los Reyes Católicos desde Londres en 1498 es una de las fuentes fundamentales sobre las primeras expediciones inglesas a Norteamérica. En este estudio se presenta la historia de su descifrado, interpretación y traducción y, constatando que ninguna de las transcripciones realizadas hasta ahora es completamente exacta, se propone una nueva basada en un descifrado literal del documento, acompañada de traducciones al francés y al inglés. Se discuten asimismo en detalle algunas frases particularmente difíciles del texto que, debido a su malinterpretación en ediciones anteriores, condujeron a conclusiones probablemente erróneas sobre la biografía de Juan Caboto, el itinerario de su viaje de 1497 y el nombre del religioso que fue con él en su expedición de 1498.

Low-pressure evolution of arc magmas in thickened crust: The San Pedro-Linzor volcanic chain, Central Andes, Northern Chile

Science.gov (United States)

Godoy, Benigno; Wörner, Gerhard; Kojima, Shoji; Aguilera, Felipe; Simon, Klaus; Hartmann, Gerald

2014-07-01

Magmatism at Andean Central Volcanic Zone (CVZ), or Central Andes, is strongly influenced by differentiation and assimilation at high pressures that occurred at lower levels of the thick continental crust. This is typically shown by high light to heavy rare earth element ratios (LREE/HREE) of the erupted lavas at this volcanic zone. Increase of these ratios with time is interpreted as a change to magma evolution in the presence of garnet during evolution of Central Andes. Such geochemical signals could be introduced into the magmas be high-pressure fractionation with garnet on the liquidus and/or assimilation from crustal rocks with a garnet-bearing residue. However, lavas erupted at San Pedro-Linzor volcanic chain show no evidence of garnet fractionation in their trace element patterns. This volcanic chain is located in the active volcanic arc, between 22°00‧S and 22°30‧S, over a continental crust ˜70 km thick. Sampled lavas show Sr/Y and Sm/Yb ratios Chile. We relate our geochemical observations to shallow crustal evolution of primitive magmas involving a high degree of assimilation of upper continental crust. We emphasize that low pressure AFC- (Assimilation Fractional Crystallization) type evolution of the San Pedro-Linzor volcanic chain reflects storage, fractionation, and contamination of mantle-derived magmas at the upper felsic crust (<40 km depth). The ascent of mantle-derived magmas to mid-crustal levels is related with the extensional regime that has existed in this zone of arc-front offset since Late-Miocene age, and the relatively thin portion of mafic lower crust observed below the volcanic chain.

Procesos históricos y ambientales en Cerro de San Pedro, San Luis Potosí, México, 1948-1997

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Paula Andrea Martínez Chaves

2010-01-01

Full Text Available Los estudios sobre el municipio Cerro de San Pedro enfatizan la continuidad ambiental aparente que estimula la minería; sin embargo, esta lectura subvalora otras dinámicas que ocurren en la zona. Con base en observaciones directas de trabajo en campo, para realizar análisis de coberturas vegetales, entrevistas con los habitantes de la zona, revisión de cartografía e investigación de archivo, el presente trabajo muestra procesos como la explotación de recursos vegetales y el pastoreo, como actividades económicas paralelas a las labores mineras, y que no habían sido tratados hasta ahora.

ENSINO DE ASTRONOMIA NO BRASIL - 1850 A 1951 - UM OLHAR PELO COLÉGIO PEDRO II

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Yassuko Hosoume

2010-01-01

Full Text Available The teaching of Astronomy in Brazil is analyzed in the 18 programs of the Pedro II School, relative to the 1841 to 1951 reforms, based on the understanding that the curriculum is the result of a process made up of conflicts and disputes between different traditions and social conceptions. The Astronomy was first identified in the Cosmography subject, although it is absent from the curricula in some periods (1856/58 and 1951 and returns, at other times, included in subjects like Geography and/or Physics (e.g. 1858 and 1931. The non-linearity of the temporal evolution in the curriculum is also observed in the maintenance of subjects such as seasons or eclipses in all the reforms and in the disconnected absence of subject matter like the methods for the star observation or the characterization of the Sun in some of them.

Occurrence of Cryptosporidium oocysts and Giardia cysts in water supplies of San Pedro Sula, Honduras

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Solo-Gabriele Helena María

1998-01-01

Full Text Available During June 1996, water supplies of the city of San Pedro Sula, Honduras, were sampled to obtain an assessment of Cryptosporidium oocyst and Giardia cyst concentrations. Each sample was concentrated and stained with an indirect immunofluorescent antibody, and parasites were counted through microscopic analysis. In three surface water supplies, Cryptosporidium oocyst concentrations ranged from 58 to 260 oocysts per 100 L, and Giardia cysts were present in concentrations ranging from 380 to 2100 cysts per 100 L. Unlike the surface water samples, groundwater had a higher concentration of Cryptosporidium oocysts (26/100 L than Giardia cysts (6/100 L, suggesting that the groundwater aquifer protects the water supply more effectively from larger Giardia cysts. Cryptosporidium oocyst concentrations are within the typical range for surface water supplies in North America whereas Giardia cyst concentrations are elevated. Efforts should be made to protect raw water from sources of contamination.

Caracterização fenológica da goiabeira 'Pedro Sato' sob diferentes épocas de poda 'Pedro Sato' guava tree phenological characterization in different pruning times

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Ronaldo Hissayuki Hojo

2007-04-01

Full Text Available O cultivo da goiabeira na região de Lavras-MG, vem tendo grande importância, porém não há uma oferta freqüente durante o ano, concentrando muitas vezes a produção em um único período. A prática de podas escalonadas é fundamental para auxiliar o produtor a colher frutos em praticamente todos os meses do ano. Visando a esse escalonamento, objetivou-se a caracterização fenológica da goiabeira 'Pedro Sato', em quatro épocas de poda (setembro, e dezembro de 2003, março e junho de 2004. Foram utilizadas dez plantas, com quatro anos de idade, para cada época de poda. O delineamento foi de blocos casualizados, onde em cada planta foram marcados doze ramos, avaliando-se semanalmente os dados sobre os estádios fenológicos. Com as mensurações, foi possível estabelecer a indicação das diferentes fenofases da cultura, sendo a duração entre a poda e o início da brotação de 30,8 a 39,2 dias; poda ao florescimento de 68,6 a 133 dias; da abertura da flor (floração plena à maturação do fruto de 118,3 a 148,4 dias; e o ciclo poda à colheita foi em média de 214,2, 211,4, 247,8 e 237,3 dias para as podas realizadas em setembro, dezembro, março e junho.Although the guava tree cultivation in the area of Lavras, MG, has had great importance, there is not a frequent offer during the year, concentrating the production in an only period. The practice of staggered prunings is fundamental to aid the producer to pick fruits in practically every month of the year. Seeking that stagger, it was aimed the 'Pedro Sato' guava tree phenological characterization in four pruning times (September and December of 2003, March and June of 2004. Ten four-year-old plants were used for each pruning time in randomized block design, where, in each plant, twelve branches were marked and the data were evaluated weekly on the phenological stages. It was possible to establish the indication of the different phenophases of the culture with the measuring, being

Recurrent myocardial infarctions in a young football player secondary to thrombophilia, associated with elevated factor VIII activity

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Vacek TP

2014-10-01

Full Text Available Thomas P Vacek, Shipeng Yu, Shahnaz Rehman, Blair P Grubb, Daniel Kosinski, Cherian Verghese, Ehab A Eltahawy, Shafiq Qaiser Department of Medicine, University of Toledo Medical Center, Toledo, OH, USAAbstract: Myocardial infarction (MI due to coronary atherosclerosis in young adults is uncommon; rare causes such as cocaine abuse, arterial dissection, and thromboembolism should be considered. A 21-year-old football player, and otherwise healthy African American man, developed chest pain during exercise while bench-pressing 400 lbs. Acute MI was diagnosed based on physical examination, electrocardiography findings, and elevated cardiac enzymes. Coronary arteriography showed a thrombus occluding the proximal left anterior descending artery (LAD. Aggressive antiplatelet therapy with aspirin, clopidogrel, and eptifibatide was pursued, in addition to standard post-MI care. This led to the successful resolution of symptoms and dissolution of the thrombus, demonstrated by repeat coronary arteriography. Five months later, he presented with similar symptoms during exercise after lifting heavy weights, and was found to have another acute MI. Coronary arteriography again showed a thrombus occluding the LAD. No evidence of coronary artery dissection or vasospasm was found. Only mild atherosclerotic plaque burden was observed on both occasions by intravascular ultrasound. A bare metal stent was placed at the site as it was thought this site had acted as a nidus for small plaque rupture and thrombus formation. Elevated serum factor VIII activity at 205% (reference range 60%–140% was found, a rare cause of hypercoagulability. Further workup revealed a patent foramen ovale during a Valsalva maneuver by transesophageal echocardiography. Both events occurred during weight lifting, which can transiently increase right heart pressure in a similar way to the Valsalva maneuver. In light of all the findings, we concluded that an exercise-related increase in factor

Dumbbell meningioma of the cervico-clavicular region.

Science.gov (United States)

Hlavka, V; Miklić, P; Besenski, N; Miklić, D; Franz, G

1991-01-01

The authors are reporting on a case of a 55-year-old man with an epidural meningioma in the region from the C VII. to the Th I. segment. The tumor encircled this region, and to the front and right involved the channels through which pass the C VI, C VII. and C VIII. roots. Subdurally, no tumoral mass was found. Another part of this tumor, of the same histological architecture as the epidural cervicospinal part was found in the supraclavicular region to the right, closely connected to the arteries and nerves of this region. The authors discuss the possibility of the tumoral occurrence at this site, primarily taking into account the origin of this tumor from the cells of the outer surface of the arachnoidea, i.e. cap cells which can invade the dura, with later separation from the main arachnoidal layer. The other possibility of such dumbbell meningioma occurring at the outgoing openings of the neural paths from the spinal channel should be looked for in the remnants of the arachnoidal cells in the region of the outgoing openings. In the paper are also discussed and correlated clinico-pathological, CT and angiographic findings.

El retrato del Obispo de Quito Pedro Ponce Carrasco en el Museo de América: Estudio monográfico de la pintura

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Ángel Justo Estebaranz

2017-12-01

Full Text Available Resumen: En este trabajo se analiza el retrato del XVIII obispo de Quito, don Pedro Ponce Carrasco, realizado por Francisco Albán y su hijo en 1769 y actualmente conservado en el Museo de América de Madrid. Se estudia la composición de la pintura, las fuentes grabadas utilizadas por el artista, y también el sentido de la pintura, relacionándola con las particulares circunstancias en que se encontraba el retratado en el momento del encargo. Asimismo, se aporta documentación inédita sobre el proceso de adquisición del cuadro por parte del Museo de América a mediados del siglo XX. Abstract: This paper analyzes the portrait of the XVIII bishop of Quito, Don Pedro Ponce Carrasco, painted by Francisco Albán and his son in 1769, and exhibited in the Museo de América (Madrid. We study the composition of the painting and the engraved source used by the artist. In addition, we study the meaning of the painting, relating it to the particular circumstances of the bishop at the time of the commission. Also, unpublished documents on the process of acquisition of the painting by the Museo de América in the middle of the 20th century are provided.

Potential role of a new PEGylated recombinant factor VIII for hemophilia A

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Wynn TT

2016-06-01

Full Text Available Tung Thanh Wynn,1 Burak Gumuscu,2,3 1Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, 2Pediatric Hematology-Oncology, Bon Secours Health System, St. Mary’s Hospital, Richmond, VA, 3Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Virginia, Charlottesville, VA, USA Abstract: Hemophilia A, a deficiency in the activity of coagulation factor (F VIII, is an X-linked bleeding disorder with an approximate incidence of one in 5,000 male infants. Bleeding-related complications often result in greater severity of disease, poor quality of life, surgical interventions for severe joint destruction, and shortened life span. With the availability of plasma-derived and recombinant FVIII products, the benefits of primary prophylaxis were demonstrated and is now the standard of care for patients with severe factor deficiencies. Current hemophilia research is focusing on the creation of new factor replacement therapies with longer half-lives; accessing alternative mechanisms to achieve desired hemostasis and enhance bypassing ­activity; and limiting the immunogenicity of the protein. PEGylation involves the covalent attachment of polyethylene glycol (PEG to a protein, peptide, or a small molecule drug. PEG effectively increases the molecular weight and size of the protein by creating a hydrophilic cloud around the molecule. This molecular change may reduce susceptibility of the molecule to proteolytic activity and degradation. It is also believed that PEGylation changes the surface charge of the protein that ultimately interferes with some receptor-mediated clearance processes. The half-life of PEGylated factor is more prolonged when compared to non-PEGylated full-length recombinant FVIII. The dawn of a new era in the care of hemophilia patients is upon us with the release of recombinant FVIII products with extended half-lives, and products with even more extended half

Una frontera casi invisible: los territorios al norte del Sistema Central en la Alta Edad Media (siglos VIII-XI

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Iñaki MARTÍN VISO

2009-12-01

Full Text Available RESUMEN: Los territorios al norte del Sistema Central no estuvieron sujetos a un dominio por parte de una autoridad centralizada entre los siglos VIII a XI. Los instrumentos del poder central, en especial la tributación y la organización episcopal, se descompusieron tras el siglo VIII y asumieron un papel determinante las estructuras de poder local, las cuales deben ser el principal objeto de estudio. A partir de su análisis, se descubre un espacio fronterizo abierto, con un dominio político informal, que es invisible para los poderes centrales. Palabras clave: Poderes Locales. Sitios de Altura. Necrópolis. Frontera. Tributación. Mozárabes.ABSTRACT: The territories at the North of the Iberian Central System were not ruled by any central authority between eighth and eleventh centuries. The main tools of the central power, especially the tribute and the episcopal organization, were broken down after the 8th century and the structures of local power, which must be studied particularly, got a very influential role. The analysis discover an opened frontier area, with an informal political control, that is invisible from the perspective of the central power

Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin.

Science.gov (United States)

Little, D; Said, J W; Siegel, R J; Fealy, M; Fishbein, M C

1986-06-01

Markers for endothelial cells including Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha were evaluated in paraffin secretions from formalin-fixed benign and malignant vascular neoplasms using a variety of immunohistochemical techniques, and results compared with staining for factor VIII-related antigen. Staining for Ulex appeared more sensitive than factor VIII-related antigen in identifying poorly differentiated neoplasms including haemangiosarcomas and spindle cell proliferations in Kaposi's sarcoma. Staining for blood group related antigens correlated with blood group in all cases. Ulex europaeus 1 lectin was the only marker for endothelial cells in lymphangiomas.

Oral manifestations, dental management, and a rare homozygous mutation of the PRDM12 gene in a boy with hereditary sensory and autonomic neuropathy type VIII: a case report and review of the literature.

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Elhennawy, Karim; Reda, Seif; Finke, Christian; Graul-Neumann, Luitgard; Jost-Brinkmann, Paul-Georg; Bartzela, Theodosia

2017-08-15

Hereditary sensory and autonomic neuropathy type VIII is a rare autosomal recessive inherited disorder. Chen et al. recently identified the causative gene and characterized biallelic mutations in the PR domain-containing protein 12 gene, which plays a role in the development of pain-sensing nerve cells. Our patient's family was included in Chen and colleagues' study. We performed a literature review of the PubMed library (January 1985 to December 2016) on hereditary sensory and autonomic neuropathy type I to VIII genetic disorders and their orofacial manifestations. This case report is the first to describe the oral manifestations, and their treatment, of the recently discovered hereditary sensory and autonomic neuropathy type VIII in the medical and dental literature. We report on the oral manifestations and dental management of an 8-month-old white boy with hereditary sensory and autonomic neuropathy-VIII over a period of 16 years. Our patient was homozygous for a mutation of PR domain-containing protein 12 gene and was characterized by insensitivity to pain and thermal stimuli, self-mutilation behavior, reduced sweat and tear production, absence of corneal reflexes, and multiple skin and bone infections. Oral manifestations included premature loss of teeth, associated with dental traumata and self-mutilation, severe soft tissue injuries, dental caries and submucosal abscesses, hypomineralization of primary teeth, and mandibular osteomyelitis. The lack of scientific knowledge on hereditary sensory and autonomic neuropathy due to the rarity of the disease often results in a delay in diagnosis, which is of substantial importance for the prevention of many complications and symptoms. Interdisciplinary work of specialized medical and dental teams and development of a standardized treatment protocols are essential for the management of the disease. There are many knowledge gaps concerning the management of patients with hereditary sensory and autonomic neuropathy-VIII

Retsensioon : Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare. Peatoimetaja Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. 326 lk. / Mart Nutt

Index Scriptorium Estoniae

Nutt, Mart, 1962-

2004-01-01

Arvustus: Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare / peatoim. Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. - Lisatud: Ott Heinapuu tutvustav sõnum retsenseeritud väljaande kohta lk. 193. - Vt. ka: http://www.riigikogu.ee/rito/index.php?id=11357

Assessment of goods and valuation of ecosystem services (AGAVES) San Pedro River Basin, United States and Mexico

Science.gov (United States)

Semmens, Darius; Kepner, William; Goodrich, David

2010-01-01

A consortium of federal, academic, and nongovernment organization (NGO) partners have established a collaborative research enterprise in the San Pedro River Basin to develop methods, standards, and tools to assess and value ecosystem goods and services. The central premise of ecosystem services research is that human condition is intrinsically linked to the environment. Human health and well-being (including economic prosperity) depend on important supporting, regulating, provisioning, and cultural services that we derive from our surrounding ecosystems. The AGAVES project is intended as a demonstration study for incorporating ecosystem services information into resource management policy and decisionmaking. Accordingly, a nested, multiscale project design has been adopted to address a range of stakeholder information requirements. This design will further facilitate an evaluation of how well methods developed in this project can be transferred to other areas.

Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

DEFF Research Database (Denmark)

Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing

2018-01-01

activated factor VII (rFVIIa) and recombinant factor VIII (rFVIII) in several experimental animal models using population PK modelling, and apply a simulation-based approach to evaluate how well the developed animal population PK models predict human PK. PK models were developed for rFVIIa and r...

Un poema hebreo de Alfonso de Zamora en alabanza de la versión latina bíblica de Pedro Ciruelo

OpenAIRE

Valle, Carlos del

1999-01-01

Pedro Ciruelo (siglo XVI), filósofo, teólogo y científico, natural de Daroca, hizo una traducción literal interlineal ("de verbo ad verbum") de varios libros de la Biblia hebrea. La empresa la comenzó hacia el año 1526 y aún continuaba con ella en 1538. Con motivo de la traducción literal interlineal del Pentateuco (1536), Alfonso de Zamora (n. 1474), que al parecer fue su maestro de hebreo y su mentor a lo largo de la traducción, compuso un poema en hebreo para honrar aquel magno trabajo. En...

Un conjunto singular del barroco sevillano en Granada: el Apostolado de la Basílica de las Angustias, obra de Pedro Duque Cornejo

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Manuel García Luque

2010-03-01

Full Text Available Se estudia el Apostolado escultórico que Pedro Duque Cornejo realizó entre 1713 y 1718 para la parroquia de Ntra. Sra. de las Angustias de Granada, a partir de documentación inédita que nos permite reconstruir su historia material y arrojar nueva luz sobre la presencia del artista sevillano en la ciudad. Se plantea, además, la vinculación del conjunto con la basílica romana de San Juan de Letrán.

Measurements of the ground-state ionization energy and wavelengths for the 1snp 1P1*-1s21S0 (n=4-9) lines of Mg XI and F VIII

International Nuclear Information System (INIS)

Pal'chikov, V.G.; Ya Faenov, A.; Yu Skobelev, I.

2002-01-01

The wavelengths of the 1snp 1 P 1 0 -1s 2 1 S 0 transitions in the He-like Mg XI (n = 4-9) and F VIII (n=4-8) have been measured in laser-produced plasmas. The accuracy of the present measurements (0.4-1.6 mA) is a large improvement over previous results. The Rydberg series is used to determine the ground-state ionization energy of F VIII and Mg XI: E i on (F VIII) 953.96±0.11 eV, E i on (Mg XI)=1761.88±0.15 eV. These experimental results are compared with theoretical data calculated by the 1/Z-expansion method and the HFR and MCDF approaches. Fairly good agreement between theory and experiment is observed with a precision up to 5x10 -5 . Radiative corrections to the 1s 2 1 S 0 state are analysed and compared with experiments. It is found that QED corrections to the ground-state ionization energy are significant at the present level of experimental accuracy. (author)

El modelo de televisión en Pedro Almodóvar. Cine vs televisión

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Gómez Gómez, Agustín

2012-01-01

Full Text Available En español: En este artículo planteamos el modelo de televisión que presenta Pedro Almodóvar en su filmografía. De sus dieciocho películas, excepto en tres, todas contienen de una u otra manera una referencia a la pequeña pantalla en clave crítica. A través del análisis de todos sus filmes damos cuenta de la forma en la que aparece la televisión y nos centramos en cuatro modos o funciones de la televisión en su obra. Una que tiene que ver con la forma de visualización, que hemos denominado modelo doméstico. Un segundo modelo, que llamamos realista, es el que nos viene a decir que sólo lo que sale en pantalla existe, pero Almodóvar desacraliza la realidad a través de la parodia. Un tercer modelo es una crítica a la denominada telebasura. Finalmente, un cuarto modo es la presencia de otras obras cinematográficas a través del monitor de televisión para establecer una relación intertextual con un propósito narrativo. In english: In this paper we analyze the TV model presented by Pedro Almodóvar in his filmography. Of the eighteen movies, but three, all contain, one way or another, a reference to TV in a critical sense. Through the analysis of all his films, we observe the way in which TV appears and focus on four models or functions of the TV in his work. The first one has to do with the viewing mode, which we have named “domestic model”. A second function, which we will call “realistic”, is one which means that only what appears on screen exists, but Almodóvar desecrates reality through parody. A third model is a critique of so-called junk televisión. Finally, a fourth function is the presence of other films through the TV screen to establish an intertextual relationship with a narrative purpose.

Produção e qualidade dos frutos da goiabeira 'Pedro Sato' submetida a diferentes épocas de poda Production and quality of guava fruits 'Pedro Sato' submitted to different pruning times

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Ronaldo Hissayuki Hojo

2007-03-01

Full Text Available O objetivo deste trabalho foi verificar a possibilidade de produção de goiaba de boa qualidade comercial, em diferentes épocas do ano, de acordo com podas realizadas em setembro e dezembro de 2003, março e junho de 2004. Utilizaram-se goiabeiras, cultivar Pedro Sato, com os ramos podados a 30 cm da base, sem desfolhamento, com quatro anos de idade, em delineamento de blocos ao acaso. Avaliaram-se: número de frutos produzidos, produção por planta, firmeza, sólidos solúveis (SS, acidez titulável (AT, relação SS/AT, pH e açúcares solúveis totais. Observou-se que as épocas de poda afetaram de maneira expressiva as características avaliadas. A produção de frutos por planta variou de 269,8 a 500,8 e foi inversamente proporcional ao peso dos frutos (186,9 a 205,5 g. A produção foi entre 55,5 e 93,6 kg por planta. O período de poda também influenciou as características físico-químicas dos frutos, mas não afetou a firmeza. É possível a produção de frutos de boa qualidade ao longo de nove meses do ano, com o manejo das podas.The objective of this work was to verify the possibility of fruit production at different periods, according to the pruning time (September and December 2003 and March and June 2004. The experimental design was a randomized blocks with guava plants of cultivar Pedro Sato per repetition, with four-years old, no defoliation, and branches prunned with 30 cm length. Evaluations consisted of: number of fruits per plant, plant yield, firmness, soluble solids (SS, titratable acidity (AT, SS/AT ratio, pH and total soluble sugars. It was observed that the pruning periods affected these characteristics. The fruit number per plant varied from 269.8 to 500.8. Fruit weight (186.9 to 205.5 g was inversely proportional to the yield per plant. The total yield weight of fruits varied from 55.5 to 93.6 kg per plant. The pruning period also influenced significantly physio-chemical characteristics of the fruits, but not the

[Pedro Laín Entralgo, physician and humanist].

Science.gov (United States)

Goic, Alejandro

2002-01-01

This speech of the president of the Chilean Academy of Medicine, Dr Alejandro Goic, is a tribute to the memory of the Spanish physician, scholar, historian, writer and intellectual Dr. Pedro Laín Entralgo, who died in Madrid on June 4, 2001, at the age of 93. On that occasion, the Spanish newspaper "El Pais" defined him as the last humanist. The Spanish civil war started when Laín was 28 years old and he aligned with Franco's supporters. In 1940, when he founded the magazine "El Escorial", he was separated from the official party. He and other intellectuals declared themselves in an "interior exile". His autobiographical book, "Lightening the burden on the conscience" refers to his painful personal history. He obtained the History of Medicine chair, at the Complutense University, at the age of 34 and remained at that post until his retirement in 1978. His intellectual production is magnificent and calls to a mutual understanding, hope, friendship and love. Outstanding, among others, are his books "The wait and hope", "Theory and reality of the other", "Spain as a problem", "Medicine and history", "The clinical history", "Patient physician relationship", "Medical anthropology". He directed the collective work composed of seven volumes, called "Universal History of Medicine". He was a member of the Royal Academies for Language, History and Medicine. In Chile, he was named honorary member of the Faculty of Medicine of the University of Chile and of the Academies of Language, History and Medicine. He dictated a course of Medical Anthropology that had a profound impact on the thought of Chilean physicians. In 1949 he wrote that Chile was the most solid state of Latin America and that "Chile needs to leave his traditional calm, through a historical gesture, and create the river beds required by his magnificent spiritual and geographical gifts. There is a lack of a beautiful craziness". It was an invocation for an understanding with our neighboring countries "for ever

MENINGKATKAN TANGGUNG JAWAB SOSIAL SISWA KELAS VIII MELALUI LAYANAN BIMBINGAN KELOMPOK

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Ummi Farikhatun Nisa

2012-12-01

Full Text Available The purpose of this research was to determine the efforts and success in improving students' social responsibility through group counseling services. Type of research used action research. Subjects were 12 students who had low social responsibility and being. Data collection technique used were psychological scales and observation. Data analysis techniques used are non-parametric statistics with the Wilcoxon test. Based on the calculations for the Wilcoxon test, a small amount of levels or Z value was 78.0. While Ztabel for n = 12 with an error level of 5% value is 14. So Z 78.0> 14.0 Ztabel or imply hypothesis accepted. These results demonstrate social responsibility of students prior to obtaining counseling services group at 51.93% (low. After following the guidance services at 81.51% (high. Conclusions from this research is a social responsibility to the students of class VIII SMP Putra Bangsa Bantarkawung increase after getting tutoring services group.

Manifiestos y utopías, viajes y videncia: una lectura mística de Pedro Prado

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Patricio Lizama

2012-11-01

Full Text Available En este trabajo estudiamos textos de Pedro Prado desde una perspectiva mística, la cual es entendida por el autor con un fundamento religioso y otro ético-social. Por ello, sus personajes se elevan hacia niveles últimos de realidad, pero no se apartan de la “tierra de hombres” y se convierten en videntes que anhelan la belleza y la justicia. En “La barca”, los personajes realizan un viaje horizontal y otro vertical para enfrentar el misterio; en Alsino, el viaje vertical es también para acercarse a la divinidad y el horizontal para enjuiciar el mundo rural chileno.La mediación entre el arriba y el abajo se representa con una embarcación que navega y vuela y con un hombre que camina y vuela, ambas figuras entendidas como alegorías del artista.

Pedro Páez y la misión jesuítica en Etiopía en el contexto de la unión de las Coronas de España y Portugal

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Marina Alfonso Mola

2004-01-01

Full Text Available Pedro Páez fue el religioso español que encabezó la segunda misión jesuítica en Etiopía, iniciada en 1603. Pese a su éxito en la adhesión al catolicismo del emperador Susenios, su labor se vio condicionada por su desarrollo en un área de influencia portuguesa y en un momento de rivalidad entre las diversas órdenes que actuaban en los territorios ultramarinos situados respectivamente bajo el dominio de España y Portugal.Pedro Páez was the Spanish priest who led the second Jesuit mission in Ethiopia, from 1603 on. Althought his success in submitting Emperor Susenyos to the Catholic Church, his task was conditioned by its development in a area under Portuguese influence and in a period of rivalry between diverse religious orders that acted in the overseas territories put under the dominión of Spain and Portugal.

Assessing patients' and caregivers' perspectives on stability of factor VIII products for haemophilia A

DEFF Research Database (Denmark)

DiBenedetti, D B; Coles, T M; Sharma, T

2014-01-01

Haemophilia A is a rare inherited bleeding disorder characterized by an inability of the blood to clot normally. Patients can experience spontaneous or trauma-induced joint and soft tissue bleeding and must keep coagulation factor VIII (FVIII) accessible at all times; thus, FVIII product storage...... challenges with storing FVIII products, especially storage away from home. More than half preferred storing FVIII products at room temperature vs. in the refrigerator for long periods of time. FVIII product accessibility, usage and storage affect disease management. Results support the need for more...... convenient and accessible FVIII products for patients in daily life and while travelling. In addition, the use of social media has potential value in recruiting this population....

O berço francês na nossa educação: do projeto do Colégio Pedro II ao Bac-ENEM

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Cynthia Agra de Brito Neves

2015-12-01

Full Text Available Este artigo tem por finalidade refletir sobre as raízes e os vínculos transversais do Brasil com a França a partir da investigação das heranças e influências da pedagogia francesa na formação do nosso ensino secundário, sobretudo em meados do século XIX, quando o Colégio Pedro II, a escola modelo, era referência nacional e importava currículos e programas de estudos dos lycées franceses. Almeida (2000, Doria (1997, Santos (2003, Vechia e Cavazotti et al (2003 e, principalmente, Razzini (2000 foram contribuições preciosas para constatarmos o papel das ideias libertárias e literárias dessa pedagogia na excelência desse Colégio no período do Império à República no Brasil. Criado em 1837, sob tutela do Estado e com o nome do imperador, o Colégio estabelecia um projeto de nação baseado nessas ideias. A instituição – responsável pela formação de nomes como Joaquim Manuel de Macedo, Manuel Bandeira e Pedro Nava – contava com um corpo docente de prestígio que se dedicou, durante décadas, à formação dos filhos da elite brasileira que procurava naquela escola uma educação inspirada no modelo clássico e humanista francês.

Autenticidad y utopía: el reparto de lo sensible en Pedro Henríquez Ureña, Alfonso Reyes y Mariano Picón Salas

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Ioannis Antzus Ramos

2017-07-01

Full Text Available En este trabajo abordo el pensamiento cultural y estético de Pedro Henríquez Ureña, Alfonso Reyes y Mariano Picón Salas. Para ello me centro principalmente en los ensayos que los tres escritores publicaron en los años veinte y treinta del siglo pasado y destaco las afinidades entre sus planteamientos. Al analizar sus ideas sobre la cultura y la estética del continente concluyo que los tres intelectuales propusieron una misma ordenación del mundo. La utopía occidentalista que ellos anhelaban está marcada por las nociones de consenso y autenticidad y tiene implicaciones políticas. In this article, I study the cultural and aesthetic thought of Pedro Henríquez Ureña, Alfonso Reyes, and Mariano Picón Salas. In order to do this, I take into consideration the essays that the three writers published in the 1920s and 1930s, and I underline the similarities among their ideas. The analysis of their cultural and aesthetic thought shows that the three intellectuals proposed a similar order of the world. The pro-Western utopia that they longed for is marked by the notions of consensus and authenticity and has political implications.

Cross-shelf transport into nearshore waters due to shoaling internal tides in San Pedro Bay, CA

Science.gov (United States)

Noble, Marlene A.; Burt Jones,; Peter Hamilton,; Xu, Jingping; George Robertson,; Rosenfeld, Leslie; John Largier,

2009-01-01

In the summer of 2001, a coastal ocean measurement program in the southeastern portion of San Pedro Bay, CA, was designed and carried out. One aim of the program was to determine the strength and effectiveness of local cross-shelf transport processes. A particular objective was to assess the ability of semidiurnal internal tidal currents to move suspended material a net distance across the shelf. Hence, a dense array of moorings was deployed across the shelf to monitor the transport patterns associated with fluctuations in currents, temperature and salinity. An associated hydrographic program periodically monitored synoptic changes in the spatial patterns of temperature, salinity, nutrients and bacteria. This set of measurements show that a series of energetic internal tides can, but do not always, transport subthermocline water, dissolved and suspended material from the middle of the shelf into the surfzone. Effective cross-shelf transport occurs only when (1) internal tides at the shelf break are strong and (2) subtidal currents flow strongly downcoast. The subtidal downcoast flow causes isotherms to tilt upward toward the coast, which allows energetic, nonlinear internal tidal currents to carry subthermocline waters into the surfzone. During these events, which may last for several days, the transported water remains in the surfzone until the internal tidal current pulses and/or the downcoast subtidal currents disappear. This nonlinear internal tide cross-shelf transport process was capable of carrying water and the associated suspended or dissolved material from the mid-shelf into the surfzone, but there were no observation of transport from the shelf break into the surfzone. Dissolved nutrients and suspended particulates (such as phytoplankton) transported from the mid-shelf into the nearshore region by nonlinear internal tides may contribute to nearshore algal blooms, including harmful algal blooms that occur off local beaches.

Hubungan Self-esteem dan Penggunaan Media Sosial Instagram dengan Perilaku Narsisme di Kalangan Siswa Kelas VIII Smpk Penabur Bintaro Jaya

OpenAIRE

Wibowo, Yonatan; Silaen, Sondang Maria J

2018-01-01

Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya hubungan self-esteem dan penggunaanmedia sosial Instagram dengan perilaku narsisme di kalangan siswa kelas VIII SMPK Penabur Bintaro Jaya.Dalam penelitian ini terdapat tiga variabel, yaitu perilaku narsisme sebagai variabel terikat serta self-esteem danpenggunaan media sosial Instagram sebagai variabel bebas. Sampel dalam penelitian ini adalah siswa kelasdelapan tahun pelajaran 2016/2017. Teknik pengambilan sampel dalam penelitia...

Emerging pollutants in the Esmeraldas watershed in Ecuador: discharge and attenuation of emerging organic pollutants along the San Pedro-Guayllabamba-Esmeraldas rivers.

Science.gov (United States)

Voloshenko-Rossin, A; Gasser, G; Cohen, K; Gun, J; Cumbal-Flores, L; Parra-Morales, W; Sarabia, F; Ojeda, F; Lev, O

2015-01-01

Water quality characteristics and emerging organic pollutants were sampled along the San Pedro-Guayllabamba-Esmeraldas River and its main water pollution streams in the summer of 2013. The annual flow rate of the stream is 22 000 Mm(3) y(-1) and it collects the wastewater of Quito-Ecuador in the Andes and supplies drinking water to the city of Esmeraldas near the Pacific Ocean. The most persistent emerging pollutants were carbamazepine and acesulfame, which were found to be stable along the San Pedro-Guayllabamba-Esmeraldas River, whereas the concentration of most other organic emerging pollutants, such as caffeine, sulfamethoxazole, venlafaxine, O-desmethylvenlafaxine, and steroidal estrogens, was degraded to a large extent along the 300 km flow. The mass rate of the sum of cocaine and benzoylecgonine, its metabolite, was increased along the stream, which may be attributed to coca plantations and wild coca trees. This raises the possibility of using river monitoring as an indirect way to learn about changes in coca plantations in their watersheds. Several organic emerging pollutants, such as venlafaxine, carbamazepine, sulphamethoxazole, and benzoylecgonine, survived even the filtration treatment at the Esmeraldas drinking water system, though all except for benzoylecgonine are found below 20 ng L(-1), and are therefore not likely to cause adverse health effects. The research provides a way to compare drug consumption in a major Latin American city (Quito) and shows that the consumption of most sampled drugs (carbamazepine, venlafaxine, O-desmethylvenlafaxine, sulphamethoxazole, ethinylestradiol) was below their average consumption level in Europe, Israel, and North America.

Il ruolo di El Escorial, V.III.6 e dei suoi discendenti nella tradizione manoscritta del Lucullus

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Corinna Senore

2017-05-01

Full Text Available L’articolo riguarda un gruppo di sette codici che tramanda il testo del Lucullus di Cicerone e che appartiene al ramo della tradizione discendente dal manoscritto Wien, Österreichische Nationalbibliothek 189. I sette manoscritti costituiscono uno stadio della tradizione caratterizzato dalla presenza di tre lacune testuali. Sulla base di alcuni elementi paleografici e della presenza di una glossa riportata a margine del testo di uno di essi, El Escorial, V.III.6 (Scor4, e inglobata all’interno del testo degli altri sei, è possibile individuare in Scor4 il capostipite di questo gruppo della tradizione. Lo studio si occupa inoltre di fare chiarezza sui rapporti che intercorrono tra i sei discendenti di Scor4. The article focuses on a group of seven codices which carry the text of Cicero’s Lucullus. This group belongs to the branch of the tradition descending from the manuscript Wien, Österreichische Nationalbibliothek 189. The seven manuscripts represent a step of the tradition marked by the presence of some textual lacunas. I start from some paleographic elements and from the presence of a gloss on text’s margin of one of them, El Escorial, V.III.6 (Scor4. The gloss has been then incorporated in the text of the other six manuscripts and I assume that Scor4 is the founder of this group of tradition. Furthermore, this article aims to clarify the relations between the six descendants of Scor4.

Los genoveses, el adelantado Pedro Fajardo y Enrique IV: comercio, fraudes y ambiciones territoriales en el Reino de Murcia (1454-1474

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Quinteros Cortés, Javier

2011-06-01

Full Text Available This article analyzes the exceptional privileges that Governor Pedro Fajardo and the City Council of Murcia granted to the Genoese merchants between 1454 and 1474, mostly to the Negro and Spínola families, to import and export products to and from the other extreme of the border of the Kingdom of Granada, with guaranteed insurances for the incomes of the city. This security proves an absence of danger in the commercial transit in the coasts of Granada and challenges the idea of rivalry between the Governor and the king of Granada formulating a new hypothesis: a mercantile alliance between both ringleaders that protected the Kingdom of Murcia of an economic blockade on the part of Castilian king Henry IV after the conflict with the unsuccessful Alphonso XII.

El presente artículo analiza los excepcionales privilegios que el Adelantado Pedro Fajardo y el Concejo de Murcia concedieron a los mercaderes genoveses entre 1454 y 1474, principalmente a las familias Negro y Spínola, para importar y exportar productos desde y hacia el otro extremo de la frontera del Reino de Granada, con seguros avalados con las rentas de la ciudad. Esta seguridad en el tránsito comercial demuestra una ausencia de peligro en las costas granadinas que pone en entredicho la idea de rivalidad entre el Adelantado y el rey de Granada formulando una nueva hipótesis: una alianza mercantil entre ambos cabecillas que protegía al Reino de Murcia de un bloqueo económico por parte del rey Enrique IV tras el conflicto con el fallido Alfonso XII.

Un documento inédito del siglo XVIII. El padre jesuita Pedro Lozano y su primera carta anua, 1720-1730

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Svriz Wucherer, Pedro Miguel Omar

2013-06-01

Full Text Available Letters Anuas of the Jesuit Province of Paraguay are very important and historical sources necessary for the reconstruction of the cultural and evangelizing by the Company of Jesus in the territories of the River Plate. For this reason, the editing and analysis of such sources are fundamental tasks in this case we refer to the first letter Anua made by father Lozano and reporting to the father General, resident in Rome, about the context in which they developed their evangelizing work parents of the order. Besides highlighting the image of the author, father Pedro Lozano, the context in which he wrote, the role of these documents, and some of the particularities and topics that exposes the source of the first half of the eighteenth century.Las Cartas Anuas de la Provincia Jesuítica del Paraguay son fuentes históricas muy importantes e indispensables para la reconstrucción de la labor cultural y evangelizadora realizada por la Compañía de Jesús en los territorios del Río de la Plata. Por esta razón, la edición y análisis de este tipo de fuentes son tareas fundamentales, en este caso nos referiremos a la primera Carta Anua que realizó el padre Lozano y que informan al padre General, residente en Roma, acerca del contexto en los cuales desarrollaron su labor evangelizadora los padres de la orden. Además resaltaremos la figura de su autor el padre Pedro Lozano, el contexto en el cual escribió, la función que cumplieron estos documentos, y algunas de las particularidades y tópicos que expone esta fuente de la primera mitad del siglo XVIII.

Love and/in psychoanalysis: a commentary on Lacan's reading of Plato's Symposium in Seminar VIII: Transference.

Science.gov (United States)

Fink, Bruce

2015-02-01

What is love and what part does it play in psychoanalysis? Where are the analyst and the analysand situated in relation to the roles defined as those of the "lover" and the "beloved"? Jacques Lacan explores these and other questions in his soon-to-be-published Seminar VIII: Transference by providing an extensive commentary on Plato's most famous dialogue on love, the Symposium. This paper outlines some of the major points about love that grow out of Lacan's reading of the dialogue and examines their relevance to the analytic setting. Can the analyst be characterized as a sort of modern-day Socrates?

Diagnóstico de clima organizacional. Caso de estudio: Universidad de Los Andes–Táchira “Dr. Pedro Rincón Gutiérrez”

OpenAIRE

Rangel Rangel, Milagros; Castro de Bustamante, Jeannett

2013-01-01

El objetivo de la presente investigación se orienta a diagnosticar el Clima Organizacional predominante en la Universidad de Los Andes “Dr. Pedro Rincón Gutiérrez. Con esta finalidad, y asumiendo una posición de complementariedad de métodos y técnicas de carácter cuantitativo y cualitativo, se aplicó una adaptación del Cuestionario de Clima Organizacional de Litwin y Stringer (1968) a una muestra de 47 docentes seleccionados por muestreo estratificado simple. Complementariam...

Pigmentos de pinturas rupestres pré-históricas do sítio Letreiro do Quinto, Pedro II, Piauí, Brasil

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Tetisuelma Leal Alves

2011-01-01

Full Text Available The Letreiro do Quinto rock shelter is located in the rural area of the city of Pedro II, Piauí, Brazil. The sandstone walls of the shelter are covered with prehistoric rupestrian paintings, painted in patterns of yellow and light and dark red hues. The chemical-mineralogical characterization of the prehistoric pigments was made with energy dispersive spectroscopy, scanning electron microscopy, energy dispersive X-ray fluorescence and 57Fe transmission Mössbauer spectroscopy at 110 K. Results confirm the occurrence of hematite- and goethite-rich ochres and also that the pigment layers are indeed made of a mixture of clay minerals mixed with iron oxides.

20 CFR 404.535 - How much will we withhold from your title VIII and title XVI benefits to recover a title II...

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title... Officer § 404.535 How much will we withhold from your title VIII and title XVI benefits to recover a title II overpayment? (a) If past-due benefits are payable to you, we will withhold the lesser of the...

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis

NARCIS (Netherlands)

Valentino, L. A.; Pipe, S. W.; Collins, P. W.; Blanchette, V. S.; Berntorp, E.; Fischer, K.; Ewenstein, B. M.; Oh, M.; Spotts, G.

2016-01-01

Introduction: We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been

Culturalism and the "New" Poetry. A Poem by Pedro Gimferrer: "Cascabeles" from Arde el mar (1966

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Guillermo Carnero

1992-01-01

Full Text Available The study deals with the group of Spanish poets commonly called the "novisimos" or "promocion de 1970," using as a base a poem by Pedro Gimferrer published in 1966. It studies the aesthetic break-through achieved by this generation, highlighting the concept of "culturalism" that critics used to define it twenty years ago. It examines the equivocal uses to which this concept can be put, and describes its correct meaning in the light of the aesthetic to which it refers. It then studies the mechanisms implicit in the writing of this non-confessional lyric poetry, centering it on two complementary procedures: the use of a historical persona that serves as an analogue ("personaje historico analogico", and that of another work of art that functions as an objectifying device ("obra de arte ajena objetivadora". It considers these in the light of two perspectives: the overcoming of neo-romantic rhetoric, and the participation of the reader.

PHYSICAL AND CHEMICAL DEGRADATION OF AGRICULTURAL SOILS AT SAN PEDRO LAGUNILLAS, NAYARIT

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Gelacio Alejo Santiago

2012-08-01

Full Text Available The objective of this study was to evaluate the degradation to propose strategies for remediation and recovery of agricultural soils of San Pedro Lagunillas, Nayarit, Mexico; considering physical and chemical properties. Soils maintained with natural vegetation but slightly grazed and agricultural soils used for more than 20 years for the production of several crops, were compared. Eight sites were studied (four cultivated and four uncultivated, each agricultural lands (cultivated was located at a distance of 30 to 80 m from its counterpart or soil with natural vegetation (uncultivated. Samples were obtained from the following layers: 0 to 10, 10 to 20 and 20 to 30 cm. The variables evaluated were: particles smaller than 2 mm, pH, organic matter, extractable phosphorus, exchangeable potassium, calcium and magnesium; soil texture and water infiltration rate. An analysis of variance and Tukey means test (α = 0.05 was applied. It was concluded that traditional farming practices led to adverse changes in soil chemical properties, in the upper 20 cm soil layer. Physical properties were also affected because infiltration film and water infiltration rate decreased about 50% in cultivated soils. The overall results in this work evident the need to take appropriate measures to prevent the physical and chemical degradation of cultivated soils in order to preserve this resource and maintain their productivity.

La articulación retórico-estilística de las perífrasis verbales de infinitivo y gerundio en "Pedro Páramo"

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Adriana Ávila-Figueroa

2012-07-01

Full Text Available ResumenEl tema de las perífrasis verbales es uno de los más complejos y debatidos en la tradición gramatical. Las descripciones propuestas en las gramáticas y estudios dedicados al tema de las perífrasis verbales explican principalmente tres valores: temporal, aspectual y modal. Gómez Torregop señala que entre estos valores es posible añadir el estilístico. El propósito de este trabajo es describir el uso de las perífrasis verbales de infinitivo y gerundio en la novela mexicana "Pedro Páramo" de Juan Rulfo y su articulación retórico-estilística.Palabras clave: figuras retóricas, perífrasis verbales, estilística, infinitivo y gerundio.AbstractThe verbal periphrasis is one of the more complex and debated topics in the grammatical tradition. The current descriptions proposed by the main reference grammars as well as by most of the works dedicated to the verbal periphrasis explain three main values: temporal, aspectual and modal. Gómez Torrego points that between these values is possible to add the stylistic one. The purpose of this article is to describe the use of the infinite and gerundive verbal periphrasis in the mexican novel "Pedro Páramo" by Juan Rulfo and its rhetorical and stylistic articulation.Keywords: rhetorical figures, verbal periphrasis, stylistics, infinitive and gerundive.

Effectiveness of Adaptive Contextual Learning Model of Integrated Science by Integrating Digital Age Literacy on Grade VIII Students

Science.gov (United States)

Asrizal, A.; Amran, A.; Ananda, A.; Festiyed, F.

2018-04-01

Educational graduates should have good competencies to compete in the 21st century. Integrated learning is a good way to develop competence of students in this century. Besides that, literacy skills are very important for students to get success in their learning and daily life. For this reason, integrated science learning and literacy skills are important in 2013 curriculum. However, integrated science learning and integration of literacy in learning can’t be implemented well. Solution of this problem is to develop adaptive contextual learning model by integrating digital age literacy. The purpose of the research is to determine the effectiveness of adaptive contextual learning model to improve competence of grade VIII students in junior high school. This research is a part of the research and development or R&D. Research design which used in limited field testing was before and after treatment. The research instruments consist of three parts namely test sheet of learning outcome for assessing knowledge competence, observation sheet for assessing attitudes, and performance sheet for assessing skills of students. Data of student’s competence were analyzed by three kinds of analysis, namely descriptive statistics, normality test and homogeneity test, and paired comparison test. From the data analysis result, it can be stated that the implementation of adaptive contextual learning model of integrated science by integrating digital age literacy is effective to improve the knowledge, attitude, and literacy skills competences of grade VIII students in junior high school at 95% confidence level.

Evaluation of the integrity of reactor vessels designed to ASME Code, Sections I and/or VIII

International Nuclear Information System (INIS)

Hoge, K.G.

1976-01-01

A documented review of nuclear reactor pressure vessels designed to ASME Code, Sections I and/or VIII is made. The review is primarily concerned with the design specifications and quality assurance programs utilized for the reactor vessel construction and the status of power plant material surveillance programs, pressure-temperature operating limits, and inservice inspection programs. The following ten reactor vessels for light-water power reactors are covered in the report: Indian Point Unit No. 1, Dresden Unit No. 1, Yankee Rowe, Humboldt Bay Unit No. 3, Big Rock Point, San Onofre Unit No. 1, Connecticut Yankee, Oyster Creek, Nine Mile Point Unit No. 1, and La Crosse

Understanding the first Neolithic occupation of Cova d'En Pardo (Planes, Alicante: Preliminary results of the multidisciplinary analysis of levels VIII and VIIIB

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Jorge Agatángelo Soler Díaz

2014-01-01

Full Text Available We present the results of excavations carried out in the Cova d'En Pardo (Planes, Alicante, specifically the levels VIII and VIIIb. The development of a multidisciplinary project has allowed to us characterize the occupation of a small cavity by the first farming communities associated with the Neolithization process of the east of Iberian Peninsula.

Seleucid, Demotic and Mediterranean mathematics versus Chapters VIII and IX of the Nine Chapters: accidental or significant similarities?

DEFF Research Database (Denmark)

Høyrup, Jens

Similarities of geometrical diagrams and arithmetical structures of problems have often been taken as evidence of transmission of mathematical knowledge or techniques between China and “the West”. Confronting on one hand some problems from Chapter VIII of the Nine Chapters with comparable problems...... known from Ancient Greek sources, on the other a Seleucid collection of problems about rectangles with a subset of the triangle problems from Chapter IX, it is concluded, (1) that transmission of some arithmetical riddles without method – not “from Greece” but from a transnational community of traders...

Human parvovirus B19 infection in hemophiliacs first infused with two high-purity, virally attenuated factor VIII concentrates.

Science.gov (United States)

Azzi, A; Ciappi, S; Zakvrzewska, K; Morfini, M; Mariani, G; Mannucci, P M

1992-03-01

Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high-purity concentrates reduces the risk of B19 transmission, we have prospectively evaluated the rate of anti-B19 seroconversion in two groups of susceptible (anti-B19 negative) hemophiliacs infused with high-purity, heated (pasteurized) or solvent-detergent-treated factor VIII concentrates. Both products infected a relatively high proportion of patients (nine of 20).

Revisión crítica de la construcción de un mito en sacramentales El gran teatro del mundo y La vida es sueño, de Pedro Calderón de la Barca

OpenAIRE

Irene González Muñoz

2012-01-01

En este artículo se realiza una lectura de dos de los autos sacramentales de Pedro Calderón de la Barca, a partir de una revisión crítica que evidencia los presupuestos ideológicos que fundamentan estas producciones literarias.

PENGARUH PENGGUNAAN VARIASI METODE DAN MODEL PEMBELAJARAN TERHADAP HASIL BELAJAR FISIKA SISWA KELAS VIII SMPN2 MARGATIGA SEMESTER GENAP TP 2013/2014

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Eni Fitriani

2015-03-01

Full Text Available The purpose of this study was to investigate the effect of variations in the methods and models of teaching to student learning outcomes VIII SMPN2 MARGA TIGA.This research is experimental research which ofdesign completely randomized or completely randomized experimental design.The population in thisresearch is all of student VIII class in SMPN 2 MARGA TIGA2013/2014. The sample in this research is VIIIth class which totaling 34 students.In this research, conducted with three treatments of learning in a classroom.Data collection techniques in this research use the technique of the test, which tests the end (posttest were then analyzed with the test results hipotesis. From posttest analysis results of hypothesis testing using one-way ANOVA test (Completely Randomized Design at the 5% significance level value obtained results Fobs = 1.5244 and Ftab = 3.10 this shows that H0 is accepted and means variety of methods and learning models provide a similar impact on student learning outcomes.It can be concluded that all three treatments had similar quality if tailored to the needs of all three materials. 

Alcances y logros económicos y financieros de las empresas de servicios turísticos, en los cantones Quito, Cayambe y Pedro Moncayo, como resultado del marketing directo

OpenAIRE

Caicedo Armas, Cristina Cinthya; Jara Córdova, Juan José

2013-01-01

In this project it is possible to observe a detailed investigation concerning the benefits about the usage of direct marketing as a tool for communicate with the customer, from part of the enterprises which provide touristic services in the cantons of Quito, Cayambe and Pedro Moncayo. The goal is to determine its economic and financial impact with respect to their daily procedure in these organizations of touristic services....

The biggest rooftop PV plant in Latin America. An example of a pioneering project for the whole region

International Nuclear Information System (INIS)

2016-01-01

About a year ago, the largest rooftop PV installation in Latin America came online in Honduras. Inaugurated by the country’s president, Juan Orlando Hernández, in March 2015, the plant is situated on the roof of the region’s PepsiCo bottling plant, EMSULA (Embotelladora de Sula S.A.) in the town of San Pedro Sula. The project, which has become a reference in the region, has been developed over two phases, the first of which corresponds to a 259 kWp pilot project, commissioned in November 2013, to which the second phase was added last year. (Author)

Analisis Deskriptif Soal Geometri dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama Kelas VIII Berdasarkan Kriteria International Assessment TIMSS 2007

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Etik Rahayu

2012-06-01

Full Text Available Tujuan penelitian ini adalah untuk mendeskripsikan  domain kognitif dan aspek kognitif (required behavior soal matematika dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama (SMP Kelas VIII berdasarkan kriteria International Assessment TIMSS 2007 dan proporsinya. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan subjek penelitian adalah soal geometri dalam Buku Matematika Bilingual SMP. yang berjudul “Mathematics for Junior High School Grade VIII 1st Semester” dan “Mathematics for Junior High School Grade VIII 2nd Semester” karangan karangan M. Cholik Adinawan dan Sugijono. Pengumpulan data menggunakan metode observasi dan wawancara tentang penggunaan buku matematika bilingual yang paling banyak digunakan di kota semarang. Pedoman analisis soal berdasarkan kriteria International Assessment TIMSS 2007, dengan validasi hasil oleh ahli. Hasil penelitian menunjukkan bahwa soal yang dianalisis memuat satu hingga tujuh aspek kognitif. Sebagian besar soal memuat 4 aspek kognitif yaitu 44.04 %, diikuti soal dengan 3 aspek kognitif  yaitu 36, 42%,  soal dengan 2 aspek kognitif yaitu 14, 90%, kemudian 1,99% untuk soal dengan 1 atau 5 aspek kognitif, dan 0,33% untuk soal dengan 6 atau 7 aspek kognitif. Proporsi tinggi pada recall (28.26% dan compute (26.57%, diikuti dengan SRP (10.85%, implement (10.65%, retrieve (8.36%, recognize (6.17%, analyze (1.99%, measure (1.59%, generalize (1.09%, SNRP (1.00%, classify (0.80%, represent (0.80%, justify (0.80%, select (0.60%, model (0.30%, synthesis (0.20%. Secara keseluruhan berdasarkan International Assessment TIMSS 2007 soal yang termasuk domain knowing memiliki persentase paling tinggi (52.28%, domain knowing-applying (24.83%, domain knowing- reasoning (12.91%, dan hanya sedikit yang termasuk domain knowing-apllying-reasoning (3.97%. Serta terdapat 4 soal (1.32% yang mempunyai ketidaksesuaian penggunaan mathematics terms serta 1 soal (0

The Metalexicographical Contribution of Pedro A. Fuertes-Olivera and Ascensión Arribas-Baño's Pedagogical Specialised Lexicography: A Critical Review

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Dion Nkomo

2011-10-01

Full Text Available

Abstract: This article attempts to give a critical review of Pedro A. Fuertes-Olivera and Ascensión Arri-bas-Baño's Pedagogical Specialised Lexicography. It evaluates the book in view of the available meta-lexicographical literature as well as current trends in practical LSP lexicography in the wake of rapid tech-nological and information developments. The article appreciates both the methodological and theoretical frameworks within which the book identifies, investigates and addresses lexicographical problems. The ap-proaches make the book an important academic contribution with critical insights for metalexicographers, especially in the area of dictionary criticism. The theoretical insights provided in the book further possess the potential to accomplish exactly what metalexicography ought to accomplish, i.e. to facilitate the production of user-friendly dictionaries which meet both the reference needs and reference skills of the targeted users. A few concerns are, however, raised mainly regarding the technical aspects of the book. While these may have a negative impact on the reader, they are not severe enough to discredit the rigour with which the book was conceived.

Keywords: METALEXICOGRAPHY, PEDAGOGICAL SPECIALISED LEXICOGRAPHY, MONOLINGUAL LSP DICTIONARY, BILINGUAL LSP DICTIONARY, MEANING REPRE-SENTATION, DICTIONARY STRUCTURES, DEFINITIONS, EQUIVALENCE, EXAMPLES, DICTIONARY CRITICISM

Opsomming: Die metaleksikografiese bydrae van Pedro A. Fuertes-Olivera en Ascensión Arribas-Baño se Pedagogical Specialised Lexicography: 'n Kri-tiese beskouing. Hierdie artikel probeer om 'n kritiese beskouing van Pedro A. Fuertes-Olive-ra en Ascensión Arribas-Baño se Pedagogical Specialised Lexicography te gee. Dit beoordeel die boek met betrekking tot die beskikbare leksikografiese literatuur, sowel as huidige neigings in praktiese TSD leksikografie in opvolging van die vinnige tegnologiese en inligtingsontwikkelinge. Die artikel het

Analyse des propriétés hydrodynamiques des aquifères fissurés de la région de San-Pedro (Sud-Ouest de la Côte d’Ivoire

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De-Lasme, O. Z.

2012-12-01

Full Text Available San-Pedro area is localized in south-western Côte d’Ivoire and covers a surface of 6912 km². Wa t e r resources exploited in this area are constituted of surface waters and groundwater of weathered and fissured aquifers. The aims of this study are to analyze hydrodynamic properties of fissured aquifers of San-Pedro on statistical and geostatistical viewpoints for a better knowledge and management of groundwater resources. Data base includes 110 drillings tapping fissured aquifers. Transmissivity was calculated by interpreting of pumping tests with classical methods. Specific capacity was calculated at the end of the third step for all drillings after correction of drawdowns. Transmissivity and specific capacity values oscillate between 1,27.10^-6 and 8,59.10-⁴ m².s^-1 and between 1,09.10^-2 m².h^-1 et 13,2 m².h^-1, respectively. These two parameters span three orders of magnitude showing the strong heterogeneity of the medium. An empirical relationship was established between transmissivity and specific capacity of San-Pedro area. This relationship can be used to determine transmissivity in the sectors where this data is lacking. Variogram of transmissivity is characterized by a double structuring. Transmissivity assessment by kriging is satisfactory, observed and estimated values are comparable. The findings obtained in this study lead to a better understanding of hydrogeological properties of south-western Côte d’Ivoire.

[fr] La région de San-Pedro est localisée dans le sud-ouest de la Côte d’Ivoire et couvre une superficie de 6912 km². Les ressources en eau exploitées dans cette région sont constituées des eaux de surface et des eaux souterraines des aquifères des altérites et de fissures du socle précambrien. La présente étude a pour objectif d’analyser les propriétés hydrodynamiques des aquif

On existence and properties of plutonium(VIII) derivatives

Energy Technology Data Exchange (ETDEWEB)

Kiselev, Yu.M.; Dolzhenko, V.D.; Ermilov, A.Yu. [Moscow State Univ. (Russian Federation). Chemistry Dept.; Nikonov, M.V.; Myasoedov, B.F. [Russian Academy of Science, Moscow (Russian Federation). Inst. of Geochemistry and Analytical Chemistry; Tananaev, I.G. [Russian Academy of Science, Moscow (Russian Federation). Inst. of Physical Chemistry and Electrochemistry

2014-04-01

The existence of Pu(VIII) was shown in alkaline solutions and in nonpolar solvents (CCl{sub 4} and CHCl{sub 3}) on the ground of such experimental facts like extraction of plutonium species, obtained by means of ozonization of Pu(VI) alkaline solutions into CCl{sub 4} and CHCl{sub 3}; volatility of Pu compounds out of aqueous alkaline solutions, and the mentioned solvents. The product of interaction between PuO{sub 3}.0.8H{sub 2}O and XeF{sub 2} in CCl{sub 4} and CHCl{sub 3} was of the same chemical form for both cases and identical with the form of the product of volatility of Pu out of these organic solutions. The electronic absorbance spectra of these products in CCl{sub 4} and CHCl{sub 3} were fairly similar to the ones for OsO{sub 4} and RuO{sub 4}. The band of absorption in these spectra with the maximum at 332 nm corresponds to the charge transfer of metal-ligand type [π(O)→Pu], as the value of molar extinction coefficient e was found to be higher than 2 x 10{sup 3} L/mole cm. A satisfactory agreement between the energies for the transitions of PuO{sub 4} molecule designed by X{sub α}-SW method and experimental data was observed. A similar accordance was observed for the designed vibration frequency (DFT-method) with the one found as result of analysis of the vibration structure of the experimental spectra. (orig.)

Investigando os rumos da disciplina escolar Ciências no Colégio Pedro II: 1960-1970 A research about the history of the General Sciences as a school subject in the Colégio Pedro II: 1960-1970

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Marcia Serra Ferreira

2007-06-01

Full Text Available Este artigo analisa mecanismos de estabilidade e mudança curriculares produzidos no Colégio Pedro II que influenciaram os rumos da disciplina escolar Ciências no 2º segmento do Ensino Fundamental, durante os anos 1960-1970. Investigando fontes orais e escritas, afirmo que aspectos institucionais puderam contribuir para que esta sofresse influências do movimento de renovação do ensino de Ciências ocorrido no período. Tais aspectos dizem respeito ao baixo status da disciplina escolar, que possuía um caráter mais generalista, era preterida pelo catedrático e não possuía espaço físico próprio. Essas características viabilizaram mudanças em uma instituição com arraigadas tradições e com as decisões centralizadas nos catedráticos. Tais mudanças, no entanto, articularam as inovações com conteúdos e práticas do passado, inventando uma tradição que pôde agregar o tradicional/antigo com o moderno/renovado e manter o prestígio da disciplina escolar tanto internamente quanto no nível externo.This paper analyses both the stability and the curriculum changing mechanisms produced in the Colégio Pedro II, which have influenced the course of Science as a school subject in upper elementary school during the 1960-1970'. Based on written and oral sources, the researcher states that institutional aspects had contributed to the fact that the influences from the Science Education innovation movement could be processed in the school subject. The institutional aspects were related to the school subject low status due to the fact that it had a general characteristic, it was less preferred by the head of department and it had not a specific physical space for the lessons. Those characteristics allowed room for changes in a long-term traditional institution in which curriculum decisions used to be centralized on the heads of departments themselves. Such curriculum changes had articulated innovations to teaching contents and practices

ENDF/B-VIII.0: The 8th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Science.gov (United States)

Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M.-A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

2018-02-01

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

ENDF/B-VIII.0: The 8 th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Energy Technology Data Exchange (ETDEWEB)

Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M. -A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

2018-02-01

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

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Marina E Fomin

Full Text Available Liver sinusoidal endothelial cells (LSECs form a semi-permeable barrier between parenchymal hepatocytes and the blood. LSECs participate in liver metabolism, clearance of pathological agents, immunological responses, architectural maintenance of the liver and synthesis of growth factors and cytokines. LSECs also play an important role in coagulation through the synthesis of Factor VIII (FVIII. Herein, we phenotypically define human LSECs isolated from fetal liver using flow cytometry and immunofluorescence microscopy. Isolated LSECs were cultured and shown to express endothelial markers and markers specific for the LSEC lineage. LSECs were also shown to engraft the liver when human fetal liver cells were transplanted into immunodeficient mice with liver specific expression of the urokinase-type plasminogen activator (uPA transgene (uPA-NOG mice. Engrafted cells expressed human Factor VIII at levels approaching those found in human plasma. We also demonstrate engraftment of adult LSECs, as well as hepatocytes, transplanted into uPA-NOG mice. We propose that overexpression of uPA provides beneficial conditions for LSEC engraftment due to elevated expression of the angiogenic cytokine, vascular endothelial growth factor. This work provides a detailed characterization of human midgestation LSECs, thereby providing the means for their purification and culture based on their expression of CD14 and CD32 as well as a lack of CD45 expression. The uPA-NOG mouse is shown to be a permissive host for human LSECs and adult hepatocytes, but not fetal hepatoblasts. Thus, these mice provide a useful model system to study these cell types in vivo. Demonstration of human FVIII production by transplanted LSECs encourages further pursuit of LSEC transplantation as a cellular therapy for the treatment of hemophilia A.

Persistent organic pollutants in marine biota of São Pedro and São Paulo Archipelago, Brazil.

Science.gov (United States)

Dias, Patrick S; Cipro, Caio V Z; Taniguchi, Satie; Montone, Rosalinda C

2013-09-15

Remote islands, such as the São Pedro and São Paulo Archipelago (SPSPA), Brazil, are pristine areas. However, these locations are not exempt from the arrival of anthropogenic agents, such as persistent organic pollutants (POPs). The present study aimed to determine the occurrence and distribution of POPs in the marine biota of the SPSPA. Sample extractions were performed using a microwave-assisted method. The predominant compounds were PCBs and DDTs, which respectively had mean wet weight concentrations of 62.23 and 9.23 ng g(-1) in the tropical two-wing flying fish (Exocoetus volitans), 78.66 and 6.81 ng g(-1) in the brown booby (Sula leucogaster) and 43.40 and 3.03 ng g(-1) in the red rock crab (Grapsus grapsus). Low levels of contaminants suggest a relative degree of isolation. Occurrence and distribution profiles of PCBs support long-range atmospheric transport as the main source of contamination and demonstrate the ubiquity of these pollutants in the marine environment. Copyright © 2013 Elsevier Ltd. All rights reserved.

LÁZARO GILA MEDINA. Pedro de Mena. Madrid: Arco/Libros, 2007. 228 pp. y 124 ils.

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José Luis Requena Bravo De Laguna

2007-12-01

Full Text Available Una de las primeras monografías de la colección Ars Hispanica dirigida bajo la experta supervisión del profesor Benito Navarrete Prieto está dedicada a uno de los escultores del barroco andaluz y español más excelsos de todos los tiempos, nos referimos al granadino Pedro de Mena (1628-1688. Sin duda alguna, la aparición de esta monografía —la segunda después de la publicada por Ricardo de Orueta y Duarte en 1914— ha de celebrarse como un verdadero acontecimiento para todos los amantes de la escultura. Se armonizan en él un conocimiento riguroso de las fuentes documentales —en archivos y bibliotecas— rastreando la historia de las obras con una sorprendente minuciosidad, y una extraordinaria sensibilidad para calibrar el valor estético de la obra escultórica de Mena, hoy dispersa entre numerosas iglesias, museos y colecciones.

Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011

Science.gov (United States)

Palmer, Benedict P.; Chalmers, Elizabeth A.; Hart, Daniel P.; Liesner, Ri; Rangarajan, Savita; Talks, Katherine; Williams, Michael; Hay, Charles R. M.

2014-01-01

The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the National Haemophilia Database. Because exposure days (EDs) were not known for some patients, time from first treatment was used as a surrogate for rFVIII exposure. An inhibitor developed in 118 (29%) patients, 60 high and 58 low titer, after a median (interquartile range) of 7.8 (3.3-13.5) months from first exposure and 16 (9-30) EDs. Of 128 patients treated with Kogenate Bayer/Helixate NexGen, 45 (35.2%, 95% confidence interval [CI] 27.4-43.8) developed an inhibitor compared with 42/172 (24.4%, 95% CI 18.6% to 31.4%) with Advate (P = .04). The adjusted hazard ratio (HR) (95% CI) for Kogenate Bayer/Helixate NexGen compared with Advate was 2.14 (1.12-4.10) (P = .02) for high titer and 1.75 (1.11-2.76) (P = .02) for all inhibitors. When excluding UK-RODIN patients, the adjusted HR (95% CI) for high-titer inhibitors was 2.00 (0.93-4.34) (P = .08). ReFacto AF was associated with a higher incidence of all, but not high-titer, inhibitors than Advate. These results will help inform debate around the relative immunogenicity and use of rFVIII brands. PMID:25339360

Cartografia e deficiência visual: experiências no Colégio Pedro II

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Rafael Medeiros de Andrade

2014-01-01

Full Text Available O processo de construção de uma escola inclusiva perpassa um conjunto de esforços cognitivos e técnicos por parte da comunidade escolar que são necessários para a adequada educação e desenvolvimento do aluno. No que diz respeito ao ensino de Geografia para alunos deficientes visuais, fazem parte deste conjunto de medidas o domínio do sistema Braille, a confecção de materiais e mapas táteis, a gravação de textos em áudio e, entre outras, a realização de trabalhos de campo. O presente relato de experiência refere-se à um projeto de dedicação exclusiva, implementado no Colégio Pedro II de 2008 a 2010, cujo objetivo foi aprimorar o ensino de Geografia para os alunos deficientes visuais. Conclui-se que a adoção dessas medidas representa o início de um longo trabalho de toda comunidade escolar que não pode ser resumido à existência de alguns materiais táteis. Deve, por outro lado, envolver um processo de construção e adequação instrumental, acompanhado da capacitação profissional e da sensibilização da comunidade escolar.

Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico.

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Flor Yazmin Ramirez Castillo

2013-06-01

Full Text Available Contamination of surface waters in developing countries is a great concern. Treated and untreated wastewaters have been discharged into rivers and streams, leading to possible waterborne infection outbreaks and may represent a significant dissemination mechanism of antibiotic resistance genes. In this study, the water quality of San Pedro River, the main river and pluvial collector of the Aguascalientes State, Mexico was assessed. Thirty sample locations were tested throughout the River. The main physicochemical parameters of water were evaluated. Results showed high levels of fecal pollution as well as inorganic and organic matter abundant enough to support the heterotrophic growth of microorganisms. These results indicate poor water quality in samples from different locations. One hundred and fifty Escherichia coli were collected and screened by PCR for several virulence genes. Isolates were classified as either pathogenic (n = 91 or commensal (n = 59. The disc diffusion method was used to determine antimicrobial susceptibility to 13 antibiotics. Fifty-two percent of the isolates were resistant to at least one antimicrobial agent and 30.6% were multi-resistant. Eighteen E. coli strains were quinolone resistant of which 16 were multi-resistant. Plasmid-mediated quinolone resistance genes were detected in 12 isolates. Mutations at the Ser-83→Leu and/or Asp-87→Asn in the gyrA gene were detected as well as mutations at the Ser-80→Ile in parC. An E. coli microarray (Maxivirulence V 3.1 was used to characterize the virulence and antimicrobial resistance genes profiles of the fluoroquinolone-resistant isolates. Antimicrobial resistance genes such as blaTEM, sulI, sulII, dhfrIX, aph3 (strA and tet (B as well as integrons were found in fluoroquinolone resistance E. coli strains. The presence of potential pathogenic E. coli and antibiotic resistance in San Pedro River such as fluoroquinolone resistant E. coli could pose a potential threat to human

Revisión crítica de la construcción de un mito en sacramentales El gran teatro del mundo y La vida es sueño, de Pedro Calderón de la Barca

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Irene González Muñoz

2012-11-01

Full Text Available En este artículo se realiza una lectura de dos de los autos sacramentales de Pedro Calderón de la Barca, a partir de una revisión crítica que evidencia los presupuestos ideológicos que fundamentan estas producciones literarias.

Ground-Water Flow Model of the Sierra Vista Subwatershed and Sonoran Portions of the Upper San Pedro Basin, Southeastern Arizona, United States, and Northern Sonora, Mexico

Science.gov (United States)

Pool, D.R.; Dickinson, Jesse

2007-01-01

A numerical ground-water model was developed to simulate seasonal and long-term variations in ground-water flow in the Sierra Vista subwatershed, Arizona, United States, and Sonora, Mexico, portions of the Upper San Pedro Basin. This model includes the simulation of details of the groundwater flow system that were not simulated by previous models, such as ground-water flow in the sedimentary rocks that surround and underlie the alluvial basin deposits, withdrawals for dewatering purposes at the Tombstone mine, discharge to springs in the Huachuca Mountains, thick low-permeability intervals of silt and clay that separate the ground-water flow system into deep-confined and shallow-unconfined systems, ephemeral-channel recharge, and seasonal variations in ground-water discharge by wells and evapotranspiration. Steady-state and transient conditions during 1902-2003 were simulated by using a five-layer numerical ground- water flow model representing multiple hydrogeologic units. Hydraulic properties of model layers, streamflow, and evapotranspiration rates were estimated as part of the calibration process by using observed water levels, vertical hydraulic gradients, streamflow, and estimated evapotranspiration rates as constraints. Simulations approximate observed water-level trends throughout most of the model area and streamflow trends at the Charleston streamflow-gaging station on the San Pedro River. Differences in observed and simulated water levels, streamflow, and evapotranspiration could be reduced through simulation of climate-related variations in recharge rates and recharge from flood-flow infiltration.

El Museo Pedagógico "José Pedro Varela" en Internet

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Susana Maggioli

2013-12-01

Full Text Available Este trabajo propone hacer del Museo Pedagógico José Pedro Varela un Centro de Información interactivo a través del análisis de sus acervos bibliográficos y museísticos para su publicación en internet. La investigación incluye el enfoque de los siguientes aspectos: historia, actividades permanentes y temporales, exposiciones, salas, colecciones, servicios y publicaciones. Para lograr el acceso a los fondos museísticos se han implementado dos bases de datos: a Libros: la bilbioteca de investigación que contiene manuales de enseñanza y libros de pedagogía; y b Objet: objetos en exposición en diferentes salas, la cual permite la consulta interactiva a las imágenes y descripción respectivas a través de una interface de fácil manejo. Uno de los productos, el Sitio Web, refleja el tratamiento que se ha hecho de dichas áreas con el cual se pretende captar el interés del público diverso que puede acceder a él, a saber: investigadores, docentes, estudiantes de magisterio, niños, público en general, etc. a través de un portal interactivo, ágil, dinámico, de diseño modular, que incluye el uso de colores cálidos y atrayentes. El resultado que aquí se presenta es la primera etapa de un proyecto más embicioso que se encuentra en desarrollo y que culminará con la automatización de los acervos museísticos de la institución.

La dicotomía turista / viajero en De Madrid a Nápoles (1861 de Pedro Antonio de Alarcón

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Jordi Canals

2012-05-01

Full Text Available Pedro Antonio de Alarcón, the author of the book entitled From Madrid to Naples (1861, appears in its pages as a critical observer of the emerging phenomenon of organized tourism, around which he makes numerous remarks in his work. Even new editorial tools, such as tourist guides that were increasingly used by travelers in the mid-nineteenth century, are considered by Alarcón in a negative way. From a formal point of view, Alarcón’s book is a hybridisation of genres that summons innovative journalistic writing skills, literary patterns already experienced in classical travel writing (concerned mainly with diary and epistolary genres and a great deal of sketches taken d’après nature by the traveler and kept in his notebook.

Large Earthquakes at the Ibero-Maghrebian Region: Basis for an EEWS

Science.gov (United States)

Buforn, Elisa; Udías, Agustín; Pro, Carmen

2015-09-01

Large earthquakes (Mw > 6, Imax > VIII) occur at the Ibero-Maghrebian region, extending from a point (12ºW) southwest of Cape St. Vincent to Tunisia, with different characteristics depending on their location, which cause considerable damage and casualties. Seismic activity at this region is associated with the boundary between the lithospheric plates of Eurasia and Africa, which extends from the Azores Islands to Tunisia. The boundary at Cape St. Vincent, which has a clear oceanic nature in the westernmost part, experiences a transition from an oceanic to a continental boundary, with the interaction of the southern border of the Iberian Peninsula, the northern border of Africa, and the Alboran basin between them, corresponding to a wide area of deformation. Further to the east, the plate boundary recovers its oceanic nature following the northern coast of Algeria and Tunisia. The region has been divided into four zones with different seismic characteristics. From west to east, large earthquake occurrence, focal depth, total seismic moment tensor, and average seismic slip velocities for each zone along the region show the differences in seismic release of deformation. This must be taken into account in developing an EEWS for the region.

Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A.

Science.gov (United States)

Young, G; Mahlangu, J; Kulkarni, R; Nolan, B; Liesner, R; Pasi, J; Barnes, C; Neelakantan, S; Gambino, G; Cristiano, L M; Pierce, G F; Allen, G

2015-06-01

Prophylactic factor replacement, which prevents hemarthroses and thereby reduces the musculoskeletal disease burden in children with hemophilia A, requires frequent intravenous infusions (three to four times weekly). Kids A-LONG was a phase 3 open-label study evaluating the safety, efficacy and pharmacokinetics of a longer-acting factor, recombinant factor VIII Fc fusion protein (rFVIIIFc), in previously treated children with severe hemophilia A (endogenous FVIII level of hemophilia A. © 2015 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

Ambiente, pessoas e labor: APLs além do desenvolvimento econômico na mineração de opalas em Pedro II, no Piauí

OpenAIRE

Milanez, Bruno; Puppim, José Antonio

2009-01-01

Este artigo propõe que políticas públicas voltadas para arranjos produtivos lo0cais (APLs) têm um importante potencial para melhorar o desempenho dos pequenos garimpos e minas de gemas no Brasil, desde que integrem questões ambientais e sociais às ações voltadas ao desenvolvimento econômico. Esse argumento é baseado no estudo empírico dos problemas socioambientais enfrentados pelo APL de opalas em Pedro II, no Piauí. O estudo foi desenvolvido através da metodologia de estudos de caso, envolve...

«Cada página lograda es una letra al más allá». Estudio de la correspondencia Américo Castro-Pedro Salinas

OpenAIRE

Zamarreño Méndez, Fabio

2016-01-01

Este trabajo explora la correspondencia entre Pedro Salinas y Américo Castro a partir de una edición, que, a causa de la legislación vigente respecto de los derechos de autor, no puede ser publicada. Por tanto, aquí encontramos el estudio introductorio, que analiza ese epistolario desde todas las perspectivas: comenzando con un repaso teórico del subgénero epistolar, pronto se explican las dificultades en torno a la reconstrucción cronológica del epistolario. Temáticamente, se analizan difere...

COLONIZAÇÃO OU DIÁSPORAS? RESENHA C.-G. SCHWENTZEL (org., M. DANA, St.LEBRETON, Fr.PRÊTEUX, Les diásporas grecques VIII-III s. Paris, Atlande, 2012, 446 páginas, 25 euros. (Dossiê: O Mundo Antigo: Literatura e Historiografia

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José Antonio Dabdab Trabulsi

2015-09-01

Full Text Available C.-G. SCHWENTZEL (org., M. DANA, St.LEBRETON, Fr.PRÊTEUX, Les diásporas grecques VIII-III s. Paris, Atlande, 2012, 446 páginas, 25 euros.C.-G. SCHWENTZEL (org., M. DANA, St.LEBRETON, Fr.PRÊTEUX, Les diásporas grecques VIII-III s. Paris, Atlande, 2012, 446 páginas, 25 euros. Recebido em: 02/04/2015  – Aceito em 13/05/2015

Transgenic rabbits as a model organism for production of human clotting factor VIII

International Nuclear Information System (INIS)

Vasicek, D.; Chrenek, P.; Makarevich, A.; Bauer, M.; Jurcik, R.; Suvegova, K.; Rafay, J.; Bulla, J.; Hetenyi, L.; Erickson, J.; Paleyanda, R.K.

2005-01-01

Human clotting factor VIII (hFVIII) is a very complex and large protein whose expression is difficult, as hFVIII requires extensive post-translational modification to be biologically active. This paper reports the generation of transgenic rabbits as a model species for testing the expression of hFVIII in the mammary gland. For micro-injection, a fusion gene construct was used, consisting of 2.5 kb murine whey acidic protein (mWAP) promoter, 7.2 kb cDNA of hFVIII, and 4.6 kb of 3' flanking sequences of the mWAP gene. from 130 micro-injected zygotes transferred into recipients, 30 offspring were delivered. The pups were screened for the transgene by PCR, using DNA isolated from the ear, and results were confirmed by Southern blot analysis. The transgene was identified in one female founder animal, and it was transmitted to the offspring in a Mendelian fashion, thus demonstrating stable integration of the gene construct into the germline of the transgenic rabbits. (author)

La vida en torno al café: marginación social de pequeños productores en San Pedro Cafetitlán, Oaxaca, México

OpenAIRE

Israel Morales Becerra

2013-01-01

Se presenta una descripción etnográfica del trabajo de campo realizado en San Pedro Cafetitlán, Oaxaca, México sobre la situación de marginación social derivada de la implementación del modelo económico neoliberal; se hace una interpretación del significado que tiene el cultivo del café en la vida de los pobladores. Destaca el hecho de que las generaciones mayores de 60 años aun valoran el recurso, tienen identidad con la tierra y esperanzas en su café; sin embargo, para las nuevas generacion...

Sediment Dynamics Over a Stable Point bar of the San Pedro River, Southeastern Arizona

Science.gov (United States)

Hamblen, J. M.; Conklin, M. H.

2002-12-01

Streams of the Southwest receive enormous inputs of sediment during storm events in the monsoon season due to the high intensity rainfall and large percentages of exposed soil in the semi-arid landscape. In the Upper San Pedro River, with a watershed area of approximately 3600 square kilometers, particle size ranges from clays to boulders with large fractions of sand and gravel. This study focuses on the mechanics of scour and fill on a stable point bar. An innovative technique using seven co-located scour chains and liquid-filled, load-cell scour sensors characterized sediment dynamics over the point bar during the monsoon season of July to September 2002. The sensors were set in two transects to document sediment dynamics near the head and toe of the bar. Scour sensors record area-averaged sediment depths while scour chains measure scour and fill at a point. The average area covered by each scour sensor is 11.1 square meters. Because scour sensors have never been used in a system similar to the San Pedro, one goal of the study was to test their ability to detect changes in sediment load with time in order to determine the extent of scour and fill during monsoonal storms. Because of the predominantly unconsolidated nature of the substrate it was hypothesized that dune bedforms would develop in events less than the 1-year flood. The weak 2002 monsoon season produced only two storms that completely inundated the point bar, both less than the 1-year flood event. The first event, 34 cms, produced net deposition in areas where Johnson grass had been present and was now buried. The scour sensor at the lowest elevation, in a depression which serves as a secondary channel during storm events, recorded scour during the rising limb of the hydrograph followed by pulses we interpret to be the passage of dunes. The second event, although smaller at 28 cms, resulted from rain more than 50 km upstream and had a much longer peak and a slowly declining falling limb. During the

Pasajes de una vuelta al mundo. El Oriente de Pedro Cubero Sebastián en su periplo universal

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Córdoba, Joaquín Mª

2005-04-01

Full Text Available Entre 1671 y 1679, un sacerdote español llamado Don Pedro Cubero Sebastián, como predicador apostólico y explorador que iba a abrir camino a posteriores misioneros católicos, dio por primera vez la vuelta al mundo en sentido inverso al tradicional. Por tierra y mar, cruzando inmensos desiertos y cordilleras, mares y ríos caudalosos, durante ocho años viajó por Europa, Oriente Próximo y la India, Malaca, Filipinas y América hasta tornar a España navegando por el Atlántico, Tan singular sacerdote escondía el espíritu de un verdadero viajero y explorador, enamorado de los mundos distantes, los recónditos paisajes y las costumbres de los más diferentes pueblos. Su figura es una muestra más de la constancia y la original audacia de los viajeros españoles de su siglo.…

Monasteries and social networks in the early medieval el Bierzo region

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Iñaki Martín Viso

2011-04-01

Full Text Available This article analyses the influence of monasteries on the creation of social networks based on the specific case of the El Bierzo region. Six monasteries were chosen (Santa Leocadia de Castañeda, Santos Cosme y Damián de Burbia, San Salvador de Bárcena, San Pedro de Montes, Santiago de Peñalba, and San Julián de Samos in order to study three different parameters: the social agents that interacted with the monasteries, the shaping of the monastical estates and the geographical scale of their domains. As a result of this analysis, a typology based on the way in which the social networks were organized (monasteries of local scale, monasteries with religious prestige, and monasteries linked to the monarchy, has been clearly identified. Additionally, it highlights the existence of a decentralized social pattern in which the different aristocratic groups coexisted without fierce competition because they developed on a local-regional scale, in which the monasteries served as stage for their power.

AKTIVITAS FISIK, ASUPAN ENERGI, DAN PRODUKTIVITAS KERJA PRIA DEWASA: STUDI KASUS DI PERKEBUNAN TEH MALABAR PTPN VIII BANDUNG, JAWA BARAT

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Noni Eka Jaya Wardani

2012-03-01

Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 The cross sectional design was used in this study to elaborate physical activity, energy consumption, and work productivity of men workers. The total number of sample is 72 men.  The inclusion criteria of  the sample is the head of household’s women tea pickers at Tea Plantation PTPN VIII Bandung, West Java who have children 0-72 month age and willing to be interviewed. The place of the research was chose purposively. Malabar Plantation was chosen from the other five plantations (clusters cause of its easier access and the homogenous characteristics inter cluster. Data collected was analyzed statistically. In general, more than a half of samples had  active or moderately physical activity  level (PAL=1.89. The physical activity level of samples during work day (average PAL=1.93 was higher than holiday (average PAL=1.77 (p87.2 - 121.2%.  Majority of samples (76.4% had wages per month below the regional minimum wages. The working hours of more than a half of samples were below seven hours per day and had wages per hour below standard regional minimum wage. Based on correlation analysis, there are significant correlation between 1 education level with physical activity level; 2 age, income per capita, and family size with wage per month; 3 age and physical activity level with working hours; and 4 age and  income per capita with wages per hour. Keywords:  physical activity, energy expenditure, energy   adequacy level, work productivity, tea picker’s household   head.

Diagnostic accuracy study of a factor VIII ELISA for detection of factor VIII antibodies in congenital and acquired haemophilia A.

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Batty, Paul; Moore, Gary W; Platton, Sean; Maloney, James C; Palmer, Ben; Bowles, Louise; Pasi, K John; Rangarajan, Savita; Hart, Daniel P

2015-10-01

Antibody formation to factor VIII (FVIII) remains the greatest clinical and diagnostic challenge to the haemophilia-treating physician. Current guidance for testing for inhibitory FVIII antibodies (inhibitors) recommends the functional Nijmegen-Bethesda assay (NBA). A FVIII ELISA offers a complementary, immunological approach for FVIII antibody testing. It was the aim of this study to retrospectively evaluate the performance of a FVIII ELISA (index) for detection of FVIII antibodies, compared with the NBA (reference). All samples sent for routine FVIII antibody testing at two haemophilia Comprehensive Care Centres, were tested in parallel using the NBA and a solid-phase, indirect FVIII ELISA kit (Immucor). A total of 497 samples from 239 patients (severe haemophilia A=140, non-severe haemophilia A=85, acquired haemophilia A=14) were available for analysis. Sixty-three samples tested positive by the NBA (prevalence 12.7%, 95% confidence interval [CI], 9.9-15.9 %), with a median inhibitor titre of 1.2 BU/ml (range 0.7-978.0). The FVIII ELISA demonstrated a specificity of 94.0% (95%CI, 91.3-96.0), sensitivity of 77.8% (95%CI, 65.5-87.3), negative predictive value of 96.7% (95%CI, 94.5-98.2), positive predictive value 65.3% (95%CI, 53.5-76.0), negative likelihood ratio 0.2 (95%CI, 0.1-0.4), positive likelihood ratio 13.0 (95%CI, 8.7-19.3) and a diagnostic odds ratio of 54.9 (95%CI, 27.0-112.0). Strong positive correlation (r=0.77, pNBA (log adjusted) and FVIII ELISA optical density. In conclusion, FVIII ELISA offers a simple, specific, surveillance method enabling batch testing of non-urgent samples for the presence of FVIII antibodies.

Multifrequency observations of the region associated with the cometary nebulae GM24

Energy Technology Data Exchange (ETDEWEB)

Tapia, M; Roth, M; Rodriguez, L F; Canto, J; Persi, P; Ferrari-Toniolo, M; Lopez, J A

1985-12-01

The faint nebulosity GM24 = PP85 was observed at infrared (1-20 ..mu..m) and radio (6-cm and CO line) wavelengths in the vicinity of a CO ''hot spot'' reported previously. Radio continuum (6-cm) emission from an H II region was detected with the Very Large Array. Its position coincides with a 1-4 ..mu..m emission peak. CM24 appears to be the visible part of an obscured H II region that is beginning to emerge from the molecular cloud. Our infrared maps made at the Observatorio Astronomico Nacional at San Pedro Martir, show two additional (1-20 ..mu..m) peaks located at distances approx. 30 arcsec from the compact H II region, all surrounded by extended near-infrared (1-4 ..mu..m) emission. A detailed CO (J = 1 ..-->.. 0) map of the whole molecular cloud was obtained with the University of Texas Milimeter Wave Telescope. High resolution spectroscopy of the H..cap alpha.. line was also obtained with the Anglo-Australian Telescope. Our results are interpreted in terms of recent formation of three massive stars; one of which, having developed an H II region, is at a slightly later phase of its evolution. The extended near-infrared emission may arise in a reflection nebula similar to NGC 7538-Irs 9.

Multifrequency observations of the region associated with the cometary nebulae GM24

International Nuclear Information System (INIS)

Tapia, M.; Roth, M.; Rodriguez, L.F.; Canto, J.; Persi, P.; Ferrari-Toniolo, M.; Lopez, J.A.

1985-01-01

The faint nebulosity GM24 = PP85 was observed at infrared (1-20 μm) and radio (6-cm and CO line) wavelengths in the vicinity of a CO ''hot spot'' reported previously. Radio continuum (6-cm) emission from an H II region was detected with the Very Large Array. Its position coincides with a 1-4 μm emission peak. CM24 appears to be the visible part of an obscured H II region that is beginning to emerge from the molecular cloud. Our infrared maps made at the Observatorio Astronomico Nacional at San Pedro Martir, show to additional (1-20 μm) peaks located at distances approx. 30 arcsec from the compact H II region, all surrounded by extended near-infrared (1-4 μm) emission. A detailed CO (J = 1 → 0) map of the whole molecular cloud was obtained with the University of Texas Milimeter Wave Telescope. High resolution spectroscopy of the Hα line was also obtained with the Anglo-Australian Telescope. Our results are interpreted in terms of recent formation of three massive stars; one of which, having developed an H II region, is at a slightly later phase of its evolution. The extended near-infrared emission may arise in a reflection nebula similar to NGC 7538-Irs 9. (author)

Tratamiento de urgencia en la fibrilación auricular, Policlínico Pedro Borrás, Pinar del Río 2015

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Yedila Hilda Duque Pérez

2016-12-01

Full Text Available Introducción: La fibrilación auricular constituye la arritmia más frecuente dentro de los trastornos del ritmo que motivan  consulta en el servicio de urgencias. Afecta el 0,4% de la población general aumentando su incidencia con la edad, aproximadamente un 75% de portadores entre 65 y 85 años. Objetivo: Describir el tratamiento de la fibrilación auricular en el servicio de urgencias del Policlínico Pedro Borrás de la ciudad de Pinar del Río. Métodos: Se realizó una investigación prospectiva y descriptiva en pacientes con arritmias cardíacas en el servicio de urgencias del policlínico Pedro Borrás de la ciudad de Pinar del Río, de enero a marzo de 2015. Se confeccionó un modelo de encuesta computable que se aplicó a cada una de las historias clínicas, realizándose el análisis de los resultados utilizando estadígrafos de la estadística descriptiva. Resultados: La fibrilación auricular se presentó en el 67,7% de los pacientes, siendo la hipertensión arterial y la fibrilación auricular idiopática las etiologías más frecuentes. El 22,6%  presentó signos de insuficiencia cardíaca al ingreso y el 41,7% presentó más de 24 horas de evolución. La reversión a ritmo sinusal se produjo en 36 de 84 pacientes en las primeras 24 horas. El fármaco más utilizado en el episodio agudo fue la digoxina. Conclusiones: Varios factores influyeron en la no conversión a ritmo sinusal en pacientes con fibrilación auricular, pero el tiempo de evolución y la presencia de insuficiencia cardiaca permitieron estimar de la probabilidad de paso a ritmo sinusal en las primeras 24 horas.

Separation method for ions of elements of the III., IV., VI. and VIII. groups of periodical system

International Nuclear Information System (INIS)

Marhol, M.

1973-01-01

The method is presented of separating the ions of the elements of the periodic system groups III, IV, and VIII by ion exchangers. The ions are complex-bonded to a new type of ion exchanger consisting of the polycondensates of phenol with aldehydes or ketones and containing an atom of phosphorus, arsenic or antimony with an atom of sulphur or oxygen in a complex bond. The polymers of compounds containing a double bond, e.g., of butadiene, polyvinyl alcohol, polyethylene, polypropylene, and the compounds of styrene with fural may also be used for this purpose. The method is demonstrated on a case of uranium and heavy metal concentration and the separation thereof from waste waters. (L.K.)

Grotrian diagrams of highly ionized iron Fe(VIII)-Fe(XXVI)

International Nuclear Information System (INIS)

Mori, Kazuo; Otsuka, Masamoto; Kato, Takako.

1977-08-01

Energy levels and Grotrian diagrams of Fe(VIII) to Fe(XXVI) are presented. This report summarized the data published recently up to 1976, and the wavelength tables compiled were converted to the Grotrian diagrams. The diagrams showing transition from one energy level to another are called Grotrian diagrams. Typical examples of the diagrams are found in the book by Bashkin et al. In the present diagrams, all lines are drawn in parallel, and connected to the extended lines from lower levels. As the results, locally dense packing of lines and figures is avoided. The ordinate of the diagrams indicates level energy, and the J values are shown on the left side of the levels. The wavelength values in angstrom unit are written in parallel with the vertical transition lines. This vertical lines show the resonance transition having absorption oscillator strength f larger than 0.1. The present diagrams are the combination of the tables of wavelength and energy level. Accordingly, the desired wavelength and level energy are easily found. The figures of wavelength are lined up in various groups, so that the characteristics of the transition can be discriminated at a glance. Wavelength and level energy have been mostly derived from experimental spectra in laboratory or solar plasma, except a few by Fawcett's prediction. (Kato, T.)

A história do ensino de física no Brasil n o século XIX: as academias militares e o colégio Pedro II

OpenAIRE

Beneti, Alysson Cristiano [UNESP

2014-01-01

The objective of this study is to set a historical notation on the teaching of Physics in Brazil focusing three teaching institutions. The research problem is expressed by the subject: which were the characteristics of the teaching of Physics in the Real Academia de Artilharia, Fortificação e Desenho (from 1792 to 1810), Academia Real Militar (from 1810 to 1822) and in Colégio Pedro II (from 1838 to 1839)? The goal of the historical documents analysis is confronted with historical narratives ...

X-ray photographs of a solar active region with a multilayer telescope at normal incidence

Science.gov (United States)

Underwood, J. H.; Bruner, M. E.; Haisch, B. M.; Brown, W. A.; Acton, L. W.

1987-01-01

An astronomical photograph was obtained with a multilayer X-ray telescope. A 4-cm tungsten-carbon multilayer mirror was flown as part of an experimental solar rocket payload, and successful images were taken of the sun at normal incidence at a wavelength of 44 A. Coronal Si XII emission from an active region was recorded on film; as expected, the structure is very similar to that observed at O VIII wavelengths by the Solar Maximum Mission flat-crystal spectrometer at the same time. The small, simple optical system used in this experiment appears to have achieved a resolution of 5 to 10 arcsec.

Un poema hebreo de Alfonso de Zamora en alabanza de la versión latina bíblica de Pedro Ciruelo

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Carlos del Valle

2018-06-01

Full Text Available The Darocan-born Pedro Ciruelo (XVI century, philosopher, theologian and scientist, prepared a literal, interlinear (verb for verb translation of many books of the Hebrew Bible. He began this enormous task ca. 1526, and was still engaged in it twelve years later. In light of the literal, interlinear translation of the Pentateuch (1536, Alonso de Zamora (who apparently was his Hebrew teacher and academic mentor composed a Hebrew poem in praise of the masterwork. The present article includes the edition of the original Hebrew poetic text (the provenance of which is MS. 589 of the Biblioteca Universitaria of Salamanca, fol. 274, its Spanish translation, and an explanation of the importance that Ciruelo and the converso Alonso de Zamora attributed to the extremely literal translation of the Hebrew Bible.

CARACTERIZACIÓN QUÍMICA Y MINERALÓGICA DE LAS CROMITAS DE LA ZONA DE BELLO Y SAN PEDRO (DEPARTAMENTO DE ANTIOQUIA

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Camilo Andres Quintero G.

2010-10-01

Full Text Available Se caracterizaron químicamente cinco muestras de cromita de los municipios de Bello y San Pedro (Antioquia en forma semicuantitativa (Análisis Espectrográfico y cuantitativa (Absorción Atómica y Espectroscopia de Emisión con fuente de plasma de Acoplamiento Inductivo; la caracterización mineralógica de las muestras se realizó mediante DRX, ATG y ATD, Microscopía Óptica y Microscopía Electrónica de Barrido con análisis por microsonda SEM-EDS, Estos resultados muestran la factibilidad de utilizar las cromitas de estos sectores como materia prima refractaria por poseer características químicas similares a las cromitas de Cuba o Filipinas que se explotan en la actualidad.

Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries

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Cimino E

2014-12-01

Full Text Available Ernesto Cimino,1 Silvia Linari,2 Mara Malerba,3 Susan Halimeh,4 Francesca Biondo,5 Martina Westfeld5 1Dipartimento Medicina Clinica e Sperimentale, Universita’ degli Studi di Napoli Federico II, Naples, Italy; 2Agenzia per l’ Emofilia, AOU Careggi di Firenze, Florence, Italy; 3Fondazione Cà Granda Ospedale Maggiore Policlinico, Centro Emofilia e Trombosi “A Bianchi Bonomi”, Milan, Italy; 4CRC Coagulation Research Centre GmbH, Duisburg, Germany; 5Pfizer Italia, Rome, Italy Introduction: Hemophilia A treatment involves replacing the deficient coagulation factor VIII. This process may involve multiple steps that might create a barrier to adherence. A new dual-chamber syringe (DCS; FuseNGo® was recently introduced with the aim of simplifying reconstitution. Aim: This study aimed to identify factors associated with adult patients’ preferences for different coagulation factor VIII reconstitution systems and to test ease of use and patient preference for the DCS. Methods: A cross-sectional survey of adults with hemophilia A in five European countries was conducted; a subset of subjects also participated in a practical testing session of the DCS. Results: Among the 299 survey participants, the device scenario requiring the least equipment and reconstitution steps (the DCS received a median preference rating of 71 out of 100 (0 being “the least desirable” and 100 “the most desirable” rating. This was significantly higher than the other scenarios (the next highest achieved a median of 50 points; P<0.001. Participants would be more likely to use this device prophylactically (P<0.001. Among the 98 participants who tested the DCS, 57% preferred this device over their current device, 26% preferred their current device, and 17% had no preference. The DCS was rated as easier to use than current treatment devices (median score 9/10 versus 7/10 for current treatment, P=0.001. Conclusion: The survey indicates that the prefilled DCS, Fuse

[The beneficial effect of mineral waters of Fiuggi on Pope Bonifacio VIII and Michelangelo: two prominent calculous patients].

Science.gov (United States)

Androutsos, Georges

2005-09-01

Going back to the dawn of time, we deal with two historical figures, that of Pope Bonifacio VIII, and that of the hierophant of art, Michelangelo Buonarroti. The texts and the codes of the British Museum (Department of Manuscripts), of the Biblioteca Medica Laurenziana (Archivio Buonarroti) of Florence, and the Biblioteca Apostolica of Vatican, convincing detalled evidence that both figures were urological patients. It concerns two clinical cases with especially pertain to the history of lithiasis of urinary tract. Even though, both of them--the first with nephrolithiasis or gravel, and the second with a bladder stone--were historically bound with the well-known cures of Fiuggi in Italy.

Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment.

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Gouri Shankar Pandey

Full Text Available The development of neutralizing anti-drug-antibodies to the Factor VIII protein-therapeutic is currently the most significant impediment to the effective management of hemophilia A. Common non-synonymous single nucleotide polymorphisms (ns-SNPs in the F8 gene occur as six haplotypes in the human population (denoted H1 to H6 of which H3 and H4 have been associated with an increased risk of developing anti-drug antibodies. There is evidence that CD4+ T-cell response is essential for the development of anti-drug antibodies and such a response requires the presentation of the peptides by the MHC-class-II (MHC-II molecules of the patient. We measured the binding and half-life of peptide-MHC-II complexes using synthetic peptides from regions of the Factor VIII protein where ns-SNPs occur and showed that these wild type peptides form stable complexes with six common MHC-II alleles, representing 46.5% of the North American population. Next, we compared the affinities computed by NetMHCIIpan, a neural network-based algorithm for MHC-II peptide binding prediction, to the experimentally measured values and concluded that these are in good agreement (area under the ROC-curve of 0.778 to 0.972 for the six MHC-II variants. Using a computational binding predictor, we were able to expand our analysis to (a include all wild type peptides spanning each polymorphic position; and (b consider more MHC-II variants, thus allowing for a better estimation of the risk for clinical manifestation of anti-drug antibodies in the entire population (or a specific sub-population. Analysis of these computational data confirmed that peptides which have the wild type sequence at positions where the polymorphisms associated with haplotypes H3, H4 and H5 occur bind MHC-II proteins significantly more than a negative control. Taken together, the experimental and computational results suggest that wild type peptides from polymorphic regions of FVIII constitute potential T-cell epitopes

Fluorescent and X-ray diffraction analysis for industrial wastes of the Comandante Pedro Soto Alba plant

International Nuclear Information System (INIS)

Herrera, V.

1980-05-01

It is presented a qualitative X-ray elemental fluorescence and diffraction analysis of the low-nickel portion (deands) of Cuban lateritic ores from Moa and Nicaro, the tailings of the Cuba nickel plant Comandante Pedro Soto Alba (in Moa) and its magnetic concentrated fractions (results of enrichment test in magnetizing roasting and wet magnetic separation). In all samples as main phase hematite (α-Fe 2 O 3 ) is observed. In all deands samples there were also high concentrations of goethite (α-FeOOH) and aluminium hydroxide (Al(OH) 3 ). In the Nicaro deands, in addition to name above phases, a modification of delta-iron hydroxide, with Ni and/or Co substitutions in the forms delta-(Fesub(0,67)Nisub(0,33))OOH, delta-(Fesub(0,67)Cosub(0,33))OOH or delta-(Fesub(0,67)Nisub(x)Cosub(0,33-x))OOH seems possible. In Moa tailings besides the hematite, the more abundant phases are a basic hydrated aluminium sulphate and gypsum. The magnetic enriched fractions are practically by a spinel of the maghemite type, and chromium seems to be included into the spinel lattice. (author)

Hospital de Caridade São Pedro de Alcântara: assistência e saúde em Goiás ao longo do século XIX

OpenAIRE

Magalhães Sônia Maria de

2004-01-01

Este artigo apresenta aspectos da trajetória do Hospital de Caridade São Pedro de Alcântara, na cidade de Goiás, ao longo do século XIX. Instituição leiga fundada no ano de 1825, o hospital nasceu da iniciativa de um grupo local influente que reconheceu um mal social: a ausência de assistência aos destituídos e enfermos. No que se referia à assistência social, ele abarcava funções e princípios caritativos cristãos, assistindo alienados, internados em cárceres, doentes e necessitados em geral,...

Evaluation of NDVI to assess avian abundance and richness along the upper San Pedro River

Science.gov (United States)

McFarland, T.M.; van Riper, Charles; Johnson, G.E.

2012-01-01

Remote-sensing models have become increasingly popular for identifying, characterizing, monitoring, and predicting avian habitat but have largely focused on single bird species. The Normalized Difference Vegetation Index (NDVI) has been shown to positively correlate with avian abundance and richness and has been successfully applied to southwestern riparian systems which are uniquely composed of narrow bands of vegetation in an otherwise dry landscape. Desert riparian ecosystems are important breeding and stopover sites for many bird species but have been degraded due to altered hydrology and land management practices. Here we investigated the use of NDVI, coupled with vegetation, to model the avian community structure along the San Pedro River, Arizona. We also investigated how vegetation and physical features measured locally compared to those data that can be gathered through remote-sensing. We found that NDVI has statistically significant relationships with both avian abundance and species richness, although is better applied at the individual species level. However, the amount of variation explained by even our best models was quite low, suggesting that NDVI habitat models may not presently be an accurate tool for extensive modeling of avian communities. We suggest additional studies in other watersheds to increase our understanding of these bird/NDVI relationships.

La preocupación médica y religiosa del doctor Pedro López por las personas de raza negra de la ciudad de México (1582-1597

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Martínez Ferrer, Luis

2008-12-01

Full Text Available The article deals with the charitable care and assistence carried out by the Spanish physician Pedro López (1582-1597 with the non-white population in Mexico City. After a biographical sketch of López, the juridical and social situation of blacks and mulattos in Mexico City in the second half of the 16^th century is presented. Then two of López’s initiatives on behalf of the blacks are described: the founding of the hospital of the Desamparados (1582, and the request to the Third Council of Mexico (1585 for permission to create a confraternity of black men and women in the capital of New Spain.

El artículo trata de la actividad caritativa y asistencial que el médico español Pedro López (1582-1597 desarrolló con la población de color en la ciudad de México. Tras un esbozo biográfico de López, se presenta la situación jurídica y social de negros y mulatos en la urbe mexicana en la segunda mitad del siglo XVI. A continuación se describen dos iniciativas de López hacia los negros: la fundación del hospital de los Desamparados (1582 y la petición al Tercer Concilio de México (1585 del permiso para crear una cofradía de negros y negras en la capital de Nueva España.

Liquid-liquid extraction and separation of VIII group elements, especially ruthenium, by synergic combinations or aromatic polyimines and micellar cationic exchangers

International Nuclear Information System (INIS)

Vitart, X.

1991-01-01

This thesis aims to characterize and to quantify the chemical equilibria involved in d-elements liquid-liquid extraction systems, especially elements belonging to the VIII group (Fe, Ni, Co, Ru, Rh, Pd, Pt). These systems are composed of synergic combination of aromatic polyimines and micellar cationic exchangers. Substitutions are first performed in aqueous acidic media by aromatic polyimines; then extractions are operated using micellic canionic exchangers. Chemical equilibria, selectivity effects, especially those due to ion-pair formations, kinetics, extractant behaviour are analysed and quantified [fr

Perfil do usuário de crack e fatores relacionados à criminalidade em unidade de internação para desintoxicação no Hospital Psiquiátrico São Pedro de Porto Alegre (RS Profile of crack users and factors related to criminality at the detoxication ward at Hospital Psiquiátrico São Pedro, Porto Alegre, Brazil

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Cristian Fabiano Guimarães

2008-08-01

Full Text Available INTRODUÇÃO: O presente estudo transversal foi realizado com usuários de crack do sexo masculino internados na Unidade de Desintoxicação do Hospital Psiquiátrico São Pedro de Porto Alegre (RS no período de março a dezembro de 2007. O objetivo do presente estudo foi identificar o perfil sociodemográfico e de consumo de substâncias psicoativas e a presença de conduta anti-social, sintomas de ansiedade e de depressão em usuários de crack internados na Unidade de Desintoxicação do Hospital Psiquiátrico São Pedro de Porto Alegre (RS, bem como verificar fatores associados à criminalidade nessa clientela. MÉTODO: Trinta sujeitos participaram do estudo, e os instrumentos utilizados foram: questionário sociodemográfico e de avaliação do consumo de substâncias psicoativas e de antecedentes criminais com 55 questões, Mini-Exame do Estado Mental, Inventário Beck de Ansiedade, Inventário Beck de Depressão, Fagerström Test for Nicotine Dependence e Escala Analógico-Visual de Fissura. RESULTADOS: Os principais resultados apontam para uma população de adultos jovens, de cor/raça branca, com idade média de 27,3 anos e em situação de subemprego ou desemprego. A presença de antecedentes criminais foi observada em 40% da amostra e está associada a maior fissura (U = 58,00; p = 0,035, a mais sintomas de ansiedade (U = 56,50; p = 0,028 e de depressão (U = 47,00; p = 0,009. CONCLUSÕES: É freqüente a presença de antecedentes criminais em dependentes de crack e esta variável está relacionada a mais ansiedade, depressão e fissura. Estudos deste tipo permitem ampliar o conhecimento da população atendida, para delinear de forma mais efetiva o plano terapêutico para esta clientela.INTRODUCTION: This cross-sectional study was carried out with 30 crack users admitted at the male detoxication ward at Hospital Psiquiátrico São Pedro, in Porto Alegre, Brazil, from March to December, 2007. The objective of the present study was

Evaluation of Neutron Reactions on Iron Isotopes for CIELO and ENDF/B-VIII.0

Science.gov (United States)

Herman, M.; Trkov, A.; Capote, R.; Nobre, G. P. A.; Brown, D. A.; Arcilla, R.; Danon, Y.; Plompen, A.; Mughabghab, S. F.; Jing, Q.; Zhigang, G.; Tingjin, L.; Hanlin, L.; Xichao, R.; Leal, L.; Carlson, B. V.; Kawano, T.; Sin, M.; Simakov, S. P.; Guber, K.

2018-02-01

A new suite of evaluations for 54,56,57,58Fe has been developed in the framework of the CIELO international collaboration. New resolved resonance ranges were evaluated for 54Fe and 57Fe, while modifications were applied to resonances in 56Fe. The low energy part of the 56Fe file is almost totally based on measurements. At higher energies in 56Fe and in the whole fast neutron range for minor isotopes the evaluation consists of model predictions carefully adjusted to available experimental data. We also make use of the high quality and well experimentally-constrained dosimetry evaluations from the IRDFF library. Special attention was dedicated to the elastic angular distributions, which were found to affect results of the integral benchmarking. The new set of iron evaluations was developed in concert with other CIELO evaluations and they were tested together in the integral experiments before being adopted for the ENDF/B-VIII.0 library.

The transitions 4p-5s in Y VI, Zr VII, Nb VIII and Mo IX

International Nuclear Information System (INIS)

Chaghtai, M.S.Z.; Rahimullah, K.; Khatoon, S.

1976-01-01

With the help of the spectra recorded in the Physics Department of Lund University, Y VI, Zr VII, Nb VIII and Mo IX are freshly analysed. The five 4s 2 4p 4 ground levels and the ten 4s 2 4p 3 5s levels of previous analyses are confirmed in the first three spectra, except for revising in Y VI the 4p 4 1 S 0 and 4p 3 5s( 4 Ssub(3/2)) 2 levels and interchanging 5s( 2 Dsub(3/2)) 1 with 5s( 2 Dsub(3/2)) 2 . All level values are improved due to the new measurements. A new analysis of Mo IX establishing all the 4p 4 and 4p 3 5s levels is being reported. (Auth.)

Petrus Hispanus en Urbino y el bastón del Gonfaloniere: El problema Pedro Berruguete en Italia y la historiografía española

Directory of Open Access Journals (Sweden)

Marías, Fernando

2002-12-01

Full Text Available The cornerstone of the biography of the Palencian painter Pedro Berruguete is a document cited by the erudite Luigi Pungileoni (1822 in which a certain «Petrus Hispanus», painter, was in Urbino. Never transcribed or found again, this notice bears the greater part of the weight of the supposed Italian formation of one of the leading figures of Spanish Renaissance painting. Now, the discovery of this document, the transcription of its contents and the incorporation of new documents likewise previously unpublished, allow for the discernment of significant features of the until today unknown «Petrus Hispanus», as well as the reconsideration of the historiographie tradition which has maintained without question the crossed identification between these two artists.

La piedra angular de la biografía del pintor palentino Pedro Berruguete es un documento citado por el erudito Luigi Pungileoni (1822 en el que un cierto «Petrus Hispanus», pintor, se encontraba en Urbino. Nunca transcrito ni reencontrado, esta noticia soporta la mayor parte del peso de la supuesta formación italiana de una de las cabezas de la pintura española del Renacimiento. El hallazgo de dicho documento, la transcripción de su contenido y la incorporación de nuevos documentos igualmente inéditos, permiten no solo determinar rasgos significativos del hasta hoy ignoto «Petrus Hispanus», sino reconsiderar la tradición historiográfica que ha mantenido sin reservas la identificación entre los dos artistas.