Krivosheev V. V.
the paper presents an analysis of the development of the system of modern upbringing of patriotism among young people. The characteristic of the main aspects of work in the teenage environment is given. The advantages and disadvantages of modern patriotic programs are singled out, the role of patriotic education in modern Russian society is revealed. The role of school and family as the basic principles of the formation of the moral-patriotic consciousness of the child is singled out. It is n...
... family by converting two of its subsidiaries from corporations into limited liability companies: (1... Railroad Company, Patriot Rail, LLC, Patriot Rail Holdings LLC, and Patriot Rail Corp.--Corporate Family... Railroad Company (TSRR), Patriot Rail, LLC (PRL) and its subsidiaries, Patriot Rail Holdings LLC (PRH) and...
Krivosheev V. V.
Full Text Available the paper presents an analysis of the development of the system of modern upbringing of patriotism among young people. The characteristic of the main aspects of work in the teenage environment is given. The advantages and disadvantages of modern patriotic programs are singled out, the role of patriotic education in modern Russian society is revealed. The role of school and family as the basic principles of the formation of the moral-patriotic consciousness of the child is singled out. It is noted that the formation of a civic position is possible only on the basis of feelings of duty and responsibility rooted in the mind of the individual.
The Article investigates sixty-three patriotic societies etablished in the Danish conglomerat state during the Age of the Enlightenment, since they can throw light on the pre-national collective identities. it explains how the patriotic societies had both an external function in regard to society...
Miller, Richard W.
Immoral excesses of American foreign policy are so severe and so deep-rooted that American patriotism is now a moral burden. This love, which pulls toward amnesia, wishful thinking and inattention to urgent foreign interests, should be replaced by commitment to a global social movement that seeks to hem in the American empire. Teachers can advance…
... noncarrier limited liability company that owns not less than 51% of the equity interests in PRH. PRH owns 100% of the stock of Patriot. Patriot is a noncarrier holding company that owns 100% of the stock of six...). Patriot currently controls the following six Class III rail carriers: Tennessee Southern Railroad Company...
Manić Mihajlo P.
Full Text Available The study A passionate patriotism or European enslavement, from the eminent professor Petar Anđelković, represents another attempt by this author to analyze the Serbian society in the context of its development. This book is a logical continuation of his essay published in 2013, Serbian Society-without past, what is our present?, and represents a symbiosis of texts that the author has already published and in which he addresses the very relevant questions of Serbia's relations with the new world order and with the inevitable role of the European Union, as an existential challenge to the very existence of the Serbian society.
Lutovinov Vladimir Ilich
Full Text Available The article considers understanding and the main point of patriotism as one of high cultural values. The main approaches that reveal different sides of this phenomenon, its role and importance in a history of Russia in the 21st century are inferred from the analysis of viewpoints of Russian thinkers and contemporary researchers. The patriotism formation problems in Russian society and their condition are defined, the need of patriotic level rise as one of the conditions for great Russia rebirth is substantiated.
Bozhkova Viktoriia Viktorivna
Full Text Available In the article the patriotic motives essence in the appeals of manufacturers has been analyzed; the classification of means, which can be used in the appeals with patriotic implication, has been proposed; the directions of justification of expediency of patriotic motives usage for manufacturers have been defined.
... SMALL BUSINESS ADMINISTRATION Patriot Express Pilot Loan Initiative AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of extension of the Patriot Express Pilot Loan Initiative. SUMMARY: This notice extends the Patriot Express Pilot Loan Initiative in its current form through December 31, 2013...
SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION /AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY...States, Germany, and Italy to replace the U.S. Patriot air defense systems, Patriot and Hawk systems in Germany, and the Nike system in Italy. The MEADS...combat demonstrated capability against these threats. MEADS will employ a netted distributed architecture with modular components to increase
attack than is possible with actuator -driven aerodynamic control surfaces alone. The Patriot system is deployed world-wide in defense of U.S. and...Start Complete Low Rate Initial Production .. Low Rate Initial Production .. Low Rate Production First D ... First Unit EQuipped IOT &E Start...MAR 2002 SEP 2001 IOT &E Start JAN 2002 JAN 2002 JUL 2002 JAN 2002 Complete SEP 2002 SEP 2002 MAR 2003 SEP 2002 Block 2002 Production Decision OCT
L Hoyt, Crystal; Goldin, Aleah
In this research we demonstrate the powerful role of ingroup favoritism, rather than hostility, in American intergroup biases. Specifically, we take a novel perspective to understanding the relationship between political ideology and discrimination against ethnic-minority Americans by focusing on the role of patriotism. Across three studies, we show that political ideology is a strong predictor of resource allocation biases, and this effect is mediated by American patriotism and not by prejudice or nationalism. Conservatives report greater levels of patriotism than liberals, and patriotism is associated with donating more to American, as opposed to ethnic-minority American, organizations. We further show that the link between patriotism and partiality to the national group is mediated by stronger "American = White" associations. These findings have important implications for intergroup relations and diversity-related policy issues in the United States.
Full Text Available This work shows the results of the research which goal was to find, systemize and critically overview the information on a patriotic role of the falcon's organization and its members, having in mind reflex of all social-historical events in the period from the birth of falcons till the end of the Second World War. Social, economic, cultural, and in the first place political situations significantly influenced the character of falcons' organizational influence. In the stormy past falcon shared destiny if its state and nation and therefore this body-exercising organization grew in time into falcons' organization. Falcon's goal besides body exercising was aiming higher goals: moral and cultural revival, national freedom, nation's unity. With enlightening of falcon membership a strong and versatile person with the sense for national affiliation, freedom and social equality was developed. Falcons' democracy, patriotism, philanthropy, belief in ideals, contributed to falcons' reputation in population, which significantly influenced accomplishment of one of the main goals of the falcon movement - forming of the united country and accomplishment of higher range in military, economical, social and cultural plan. Research results point out that during the First World War a falcon was a supporting unity of nations into one state. Therefore falcons were convicted to prison, persecution and internment, execution and hanging at 'high treason' court processes. Patriotic spirit and strong national as well as Yugoslav sense followed falcons later on in an uncompromising battle with separatist and pro - fascist power during more frequent strokes on state's integrity. In the first days of occupation, falconry represented a cohesion and mobilization factor in people. At the beginning of the 1940 falconry counted 350.000 members, which was considered 'the second echelon' of defense of the Kingdom of Yugoslavia.
Frolov Vladimir Pavlovich
Full Text Available The article covers a relevant historical and cultural problem of elaboration and maintenance of monuments of the military glory of 1812. The author considers various architectural and sculptural monuments illustrating heroic events of Patriotic war of 1812, built in the two Russian capitals - Moscow and Saint Petersburg in different historical periods, and also in primordial Russian towns, such as Smolensk, Vyazma, and Maloyaroslavets. Architectural and composition-related features of this or that monument erected against the background of historic events of the war of 1812 are analyzed in detail. The author demonstrates the links between architecture and sculpture within the framework of town-planning solutions implemented in the pieces that have found their places in the towns enlisted above. The value of symbols of the Victory and Glory of the Russian army and the Russian people is marked. The names of the most famous heroes of this war, starting from a field marshal and ending with a soldier are inscribed. By addressing the historical and cultural heritage of Russia, the author informs readers about the most significant events of the war. The author mentions an acute problem of the modernity, that is, preservation and restoration of monuments, and shares his view point. The value of the historic and cultural heritage of Russia for military and patriotic education is emphasized. The article is prepared within the framework of the year of the Russian history.
G A Shurukhina
Full Text Available In modern society, patriotism is manifested in all spheres of human life and it is understood as a love for the motherland and its people, as a sense of duty and pride for the country, a sense of honor and personal dignity, personal responsibility for occurring events, devotion to the country and its people. Patriotism is a complex concept including patriotic feelings of an individual. In the article, the peculiarities of the manifestation of patriotic feelings in high school students are analyzed on the basis of the system-functional approach. The study involved a group of senior students of secondary comprehensive school, a group of the representatives of the Ministry of Emergency Situations and cadets of a Cadet Corps. Statistically significant differences in sixteen variables characterizing manifestation of patriotic feelings were obtained in the group of cadets, the differences were observed in degrees of manifestation of both harmonic and inharmonic variables. High values were obtained for the variables of the reflective-evaluative component. The personal difficulties have got higher values which indicates a serious and responsible approach of cadets to the manifestation of patriotic feelings. These results were used to formulate correction programs aimed at the harmonization and development of patriotism among representatives of different age groups
Full Text Available This paper reviews the political activities of the Spanish colony in Mexico during the Porfiriato, regarding the 1895-1898 war between Spain and Cuba and the United States. The author focuses on three urban centers with Spanish residents -Mexico City, Veracruz and Merida- and analyzes the subject in relation with the colony's complex ideological, social and material interests. The patriotic activities carried out by the colony until the defeat of 1898 is not explained from the diplomatic viewpoint, which is the most common, but from the creation of patriotic groups (juntas patrióticas, encouraged by the Spanish embassy and by institutions such as the Casino, the interests of which were often contrary to those of the Mexican government and even entailed conflicts with Cuban secessionist groups also active in Mexico.
.... Patriot PAC-2 is a case study in effective project management that resulted in the extraordinary acceleration in the final stages of development production and deployment in time to play a historic role in the Gulf War...
PATRIOT, the centerpiece of the Army's corps and theater air defense forces, is an extremely capable high to medium altitude, long range air defense missile system which provides air defense of ground...
New Yorgis pandi nurgakivi "Vabaduse tornile", mis rajatakse World Trade Center'i asemele. Maailma kõrgeim pilvelõhkuja plaanitakse valmis ehitada 2009. a., kogu uuendatud WTC kompleks 2015. a. Peaarhitekt on Daniel Libeskind
The article sees the rise of ‘patriotic journalism’ in recent Zimbabwe as representing something qualitatively different from any other forms of patriotism or journalism. The ‘patriotic journalism’ practiced by Jonathan Moyo’s ministry from 2000-5, was narrowly defined and destructive. At a time when Socialism had been abandoned, education and welfare undermined, patriotic journalism emerged as the Zimbabwean government’s last resort. The article unequivocally states that Zimbabweans ought no...
Жанна Васильевна Пузанова
Full Text Available Patriotism is designated as a national idea in Russia; nowadays the questions the relevance of patriotic education of the most reactive of social groups - young people - is especially acute. Round table in the format of focus groups with 20 experts working with young people, among them - professors, teachers, veterans, employees public authorities to work with youth was held on the 27th of May 2016 on the basis of the museum-panorama “Battle of Stalingrad” in Volgograd, with the assistance of the Peoples’ Friendship University of Russia. During the two-hour round table were discussed issues of civil and patriotic education of youth, including the theme - “Ultrapatriotizm-Patriotism-pseudo-patriotism” (ratio of the concepts, their similarities and differences, manifestations in modern Russian society among young people, “Today's youth and moral conflicts” (spiritually-moral development of today's youth, its values, “infantilism - the scourge of modern youth?” (problem of infantilism as a barrier in the way of civic and patriotic education, “Does extremist views attractive for young people?” (the attitude of youth to extremism and terrorism, effective countermeasures of youth involvement in extremist groups.
...-AA00 Safety Zone; USO Patriotic Festival Air Show, Atlantic Ocean; Virginia Beach, VA AGENCY: Coast... provide for the safety of life on navigable waters during the USO Patriotic Festival Air Show. This action... Patriotic Festival Air Show, Atlantic Ocean; Virginia Beach, VA. (a) Regulated Area. The following area is a...
Tikhonova, Anna U.
The paper analyzes studies on continuing education, explains the concept of "continuity of patriotic education and moral development by means of regional culture", determines the uniqueness of regional culture as the core of patriotic education and moral development, and characterizes the model of continuity of patriotic education and…
This paper explores the extent to which Charles Lucas can be described as a typical patriot in mid-eighteenth century Ireland. The political ideas and practices of Irish patriots of the mid-eighteenth century belong to broad spectrum including opposition MPs, anti-Catholic rhetoricians and questioners of the usefulness of the penal laws, economic pamphleteers and individuals interested in recovering Ireland's history and antiquities. Lucas was significant in that he sometimes inhabited all of these political and cultural guises, but also mobilised the Dublin public in political campaigns and was striking in his voluminous output in newspapers and pamphlets.
Full Text Available The relevance of the problem of educating young generation’s patriotism under modern conditions is substantiated in the article. The concept of the terms «patriotism» and «patriotic education» is considered. The concept of national-patriotic education of children and youth is analyzed. Much attention is paid to Ukrainian handicrafts educational influence on patriotic upbringing of younger generation. Work experience of the Faculty of Technology and Design оf V. G. Korolenko Poltava National Pedagogical University is presented.
Ahmed, Mumtaz; Irshad, Ayesha
The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.
Remarkably, the article observes that the exclusively women authored anthology on liberation war history offers an inventory of a gender based trajectory of memory, thus ... On the other hand, the sidelined demographic categories contest narrow 'patriotic history' by engineering counter discursive historical accounts.
Should patriotism be considered a legitimate part of schooling in a democracy? This question has been contested in the scholarly literature as well as by policy-makers for decades. Terrorism and conflict exacerbate this debate by adding a sense of urgency to both the demand to love thy country and the concern for individual freedom. In this…
This essay analyzes the recent appearance in Russian letters of ultra-nationalist fantasies about the restoration of Russia's imperial or totalitarian status. This new trend has its roots not only in the increasingly patriotic tone of Russian society and politics, but also in the dynamics of the
Full Text Available This article discuses about The Indonesian National Defense Forces (Tentara Nasional Indonesia/TNI who has been experiencing a shift from praetorian military to professional military because of fundamental change within Indonesian society after the end of the Soeharto’s regime in 1998 which is followed by a transition of power from New Order to reformed government. That shift can be seen through some issues related to territorial institutions, military business, and relation between TNI and The Ministry of Defense (Departemen Pertahanan. This paper argues that that shift and its related issues can be explained by patriot professional military thesis. This thesis combines certain aspects of Huntington’s old professionalism and Stepan’s new professionalism. As a patriot professional military TNI has professional characteristics as well as strong commitment to take a part in nondefense tasks according to decisions of civilian government. To become patriot professional military TNI needs to develop itself in a condition with objective civilian control that promotes military professionalism, and highly respects the civilian supremacy. This paper approached its problem with sociology of military, and made its inquiry with qualitative method. Tulisan ini membahas fenomena TNI yang tengah mengalami pergeseran dari militer praetorian menuju militer profesional seiring terjadinya perubahan mendasar dalam masyarakat Indonesia karena peralihan kekuasaan dari Orde Baru ke pemerintahan Reformasi pasca-berakhirnya pemerintahan Soeharto pada 1998. Pergeseran tersebut dapat dilihat dari isu-isu terkait keberadaan lembaga teritorial, bisnis militer, serta hubungan antara TNI dengan Departemen Pertahanan. Tulisan ini berargumen bahwa pergeseran tersebut dapat dijelaskan dengan tesis militer profesional patriot. Tesis ini merupakan kombinasi aspek-aspek tertentu dari tesis Huntington mengenai profesionalisme militer yang disebut profesionalisme lama dengan
Shaidenko, N. A.
One of the tasks of education in Russia is to instill a sense of patriotism among students, and this requires the creation of both a cognitive and emotional basis for patriotic commitment. (Contains 2 notes.)
This article examines the moral, political and pedagogical tensions that are created from the entanglement of patriotism and human rights, and sketches a response to these tensions in the context of critical education. The article begins with a brief review of different forms of patriotism, especially as those relate to human rights, and explains…
The paper considers Martha Nussbaum's motivation for departing from her earlier cosmopolitan position in favour of now promoting a globally sensitive patriotism. Her reasons for endorsing patriotism will be shown as exemplary for related argumentations by other authors, especially insofar as love of country as a motivating force for civic duty is…
Tranter, Bruce; Lester, Libby
Echoing the anti-pollution and resource conservation campaigns in the United States in the early-to-mid-twentieth century, some scholars advocate mobilising support for environmental issues by harnessing the notion of environmental patriotism. Taking action to reduce the impact of global warming has also been cast as a patriotic cause. Drawing upon quantitative data from a recent national survey, we examine the link between patriotism and environmental attitudes in Australia, focussing upon climate change. We find that patriotism has a largely neutral association with concern over environmental issues, with the exception of climate change and, to a lesser extent, wildlife preservation. Expressing concern over climate change appears to be unpatriotic for some Australians. Even after controlling for political party identification and other important correlates of environmental issue concerns, patriots are less likely than others to prioritise climate change as their most urgent environmental issue and less likely to believe that climate change is actually occurring.
Peña, Yesilernis; Sidanius, Jim
Using a random sample (N = 405) of White and Latino Americans from Los Angeles County, the authors explored whether there is an asymmetrical relationship between U.S. patriotism and two different dimensions of social dominance orientation: group antiegalitarianism and group dominance. Although there was no evidence of asymmetry in the relationship between U.S. patriotism and group antiegalitarianism, there was evidence of consistent asymmetry in the relationship between U.S. patriotism and group dominance. Among Whites (the dominant North American ethnic group) and depending on demographic variables such as age, education, income, and gender, the greater the respondents' tendency to subordinate "inferior groups," the greater their level of U.S. patriotism. In contrast, among Latino Americans (the major subordinate group in Southern California), the opposite trend was found. Here, higher levels of group dominance orientation were associated with lower levels of U.S. patriotism. The theoretical implications of these findings are discussed.
Kagan, I; Itzhaki, M; Melnikov, S
To examine the influence of nurses' patriotism and organizational commitment on their intention to report for work in a national emergency, in Israel. Healthcare systems need to forecast the number of staff likely to report for work in emergencies and mass casualty events. Patriotism and nurses' commitment to work are factors that prompt nurses to leave their families and report for duty, even knowing that they are putting themselves in danger. However, patriotism as a variable that might affect nurses' intention to report for work in emergencies has not been investigated. A descriptive, cross-sectional survey was used with a convenience sample of 152 registered nurses. Descriptive statistics, Pearson correlation coefficients and t-tests were used to analyse the data. To examine the unique contribution of the independent variables to the explanation of the dependent variable - intention to report to work in emergency - multiple regression analysis was performed. Significant positive correlations were found between age, seniority and research variables (organizational commitment, patriotism and intention to report for emergency work). Patriotism differed by gender, ethnicity and religion. Patriotism and gender explained 23% of the variance regarding intention to report for emergency duty, with patriotism playing a major role. Patriotism has religious and cultural dimensions. Cultural differences explain the discrepancy in organizational commitment between Israeli-born nurses and immigrants. Emergency training drills for nurses should feature discussions on universal ethical principles in emergency planning, preparedness and responses. The willingness of ethnic/religious minorities and immigrants to report for work in a national emergency should be taken into consideration in healthcare system disaster planning, so as to lessen the impact of disparate patriotism. © 2017 International Council of Nurses.
Agustin, Oscar Garcia
embedded a culture of dialogue and the conflicts became more accentuated at the end of their first term (Tusell, 2000: 239). The Spanish president, José María Aznar, interpreted the results as a big electoral support for his project and started a new orientation in some areas such as the relation...... national parties, PP and Partido Socialista (PSOE, social democrats) agreed to fight against terrorism and the nationalist environment together. In that context, Aznar undertook the definition of the nation maintaining this division and tried to find a way of formulating Spanish nationalism and getting...... some accept by the citizens. In this paper I will examine the discursive formation constituted by PP to redefine the Spanish nationalism using the idea of constitutional patriotism, which emanates from the academic debate, in competition with the social democrat party, that aspires also to apply...
Patriot Conduct of Fire Trainer PoP - Proof of Principle T - Threshold TADiL-J - Tactical Digital Information Link-Joint TADSS - Training Aids, Devices...Production Estimate Econ Qty Sch Eng Est Oth Spt Total 5.272 0.311 0.411 0.398 0.000 0.126 0.000 -0.158 1.088 6.360 Current SAR Baseline to Current...Development Estimate Changes APUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 4.957 0.287 0.286 0.398 0.000 -0.244 0.000 -0.158 0.569 5.526
Saksamaa ja Holland testivad oktoobris Patriot-tüüpi rakette. Saksa brigaadikindral Michael Gschossmanni sõnul võidakse testimisele tulevaid õhutõrjesüsteeme paigutada tulevikus Balti riikidesse või Poola
Olga Valerjevna Kashirina
Full Text Available Purpose. The work objective is to identify the focus of the meanings’ continuity and forms of patriotism in patriotic choice as the frame meaning of main life strategy that each civilized subject has- an individual, a social community of any size. The choice truthfulness is defined by presence of the meaning time continuity and approach of its structure to «the right rate». Methodology. The problem analysis is carried out on the basis of transdisciplinary dialectical and trialectical method of distinction and meaning-making with respect to intellectual technology of civilized and noospheric patriotism continuity. Results. The article regards to the continuity of meanings and forms of patriotism in the context of social time study and searches for the solution to the problem of patriotism in three lines: 1 as the problem of civilized patriotism of Great and Small Motherland, 2 as the problem of noospheric patriotism, 3 as the problem of the continuity of the meanings between them. It highlights the solution flexibility of patriotism problem that is related to the fact that social time study considers patriotism as the culture phenomenon that has the dialectical «nature of existence», and at the same time, it has three way model of civilized reality «existence» meanings – entirety of present, continuity of past and reasonability of future. The article says that the dynamic balance of meanings of civilized and noospheric patriotism in the identity culture of a civilized subject making the culture of his/her behavior and activity provides formation and stability of moral and spiritual immunity that appears by virtue of them in the semantic field of patriotism. Practical implications. The practical implication of the research is in its usability to work out courses on philosophy, culture philosophy, etc. Social time study theory can be realized in teaching practice of the new course unit «The basics of social time study» as a humanity
Eugene G. Guzhva
Full Text Available On the eve of the 70th anniversary of the Victory in the Great Patriotic War, it is important to analyze the moral factors that contributed to the uplift in the Red Army and the manifestation of mass heroism to defend the Fatherland. During the ordeal, when the fate of the country hung in the balance, the Soviet leadership was forced to revert to the heroic pages of national history and raise the patriotic spirit and the offensive of the armed forces on the front and high productivity at home. Since the 40s of the 19th century in the Russian army it was considered a holy tradition to start the evening roll call from the heroes. During the Great Patriotic War, the tradition was revived. Thus, according to the order of People's Commissar of Defense of the September 8,1943 the hero of the Soviet Union Alexander Matrosov was enlisted in the lists of the 1st company of 254-th Guards Rifle Regiment. Thus, the traditions of the Russian army, revived during the Great Patriotic War, testifies to their eternal spiritual values in matters of moral and patriotic education of servicemen of the Russian armed forces. This historical and pedagogical analysis is of great importance for the spiritual, moral and patriotic education of youth and soldiers of the Russian army at the present stage of development of society.
N. P. Ustinova
Full Text Available The aim of the publication is an experimental research of patriotic qualities of students – future engineers of the defense industry. Methods. The study is conducted with the use of system-based analysis methods, teacher modeling, observation, interviews, pedagogical testing, and questionnaires. Diagnosis and evaluation of personal qualities of students are carried out using morphological life values test (modified by I. G. Senin, and questionnaire «The need for achieving the goal» (modified by Y. M. Orlov. The reliability of the results is granted by the use of statistical processing of empirical methods. Results. The average empirical values have been obtained concerning the level of professional and patriotic education of students of defence specialties at technical universities. It has been shown that targeted educational activities carried out on the basis of the identified organizational and pedagogical conditions, contributes to the level of professional and patriotic education of students of defense specialties at a Technical University.Scientific novelty. In relation to students – future professionals of defense industry, the concept of «professional – patriotic education» is clarified, which appears to be an integrative quality of a person, including cognitive, emotion-andvalue component and rational-activity components. The organizational and pedagogical conditions of vocational patriotic education of students of defense specialties are identified; the conditions are united into two groups: the creation of professional-oriented educative environment and creating the opportunities for active participation of students in educational and professional activities. Practical significance. Designed criterion-evaluation units are used to evaluate the current level of professional and patriotic education of students. Identified set of organizational and pedagogical conditions has been implemented in the process of patriotic education
Iraq, Iceland, Canada, Costa Rica, Cuba, Lebanon, Mexico , Netherlands, Nicaragua, New Zealand, Syria, Uruguay, Chile, Ecuador, Ethiopia 4. The number...Great Patriotic War), a collection of docu- ments. Yaroslavl’ Book Publishers, 1960. ALBANIA Banca Nazionale d’Albania. Ufficio studi. Economia albanese
Christopher M. VanDemark
Full Text Available In this article, Christopher VanDemark explores the intersections between nationalism, fashion, and the royal figure in Hungary between 1857 and the Compromise of 1867. Focusing on aesthetics as a vehicle for feminine power at a critical junction in Hungarian history, VanDemark contextualizes Empress Elisabeth’s role in engendering a revised political schema in the Habsburg sphere. Foreseeing the power of emblematic politics, the young Empress adeptly situated herself between the Hungarians and the Austrians to recast the Hungarian martyrology narrative promulgated after the failed revolution of 1848. Eminent Hungarian newspapers such as the Pesti Napló, Pester Lloyd, and the Vasárnapi Újság form the backbone of this article, as publications such as these facilitated the dissemination of patriotic sentiment while simultaneously exulting the efficacy of symbolic fashions. The topic of study engages with contemporary works on nationalism, which emphasize gender and aesthetics, and contributes to the emerging body of scholarship on important women in Hungarian history. Seminal texts by Catherine Brice, Sara Maza, Abby Zanger, and Lynn Hunt compliment the wider objective of this brief analysis, namely, the notion that the Queen’s body can both enhance and reform monarchical power within a nineteenth-century milieu.
Yu. V. Il’In
Full Text Available Strengthening national defense by building up military and economic potential was the most important vital task of the Soviet Union during the whole period of its existence. The price of enormous effort of labor, research and design teams, huge material and financial costs in the course of the prewar five-year plans in the Soviet Union was paid and incurred to create the military-industrial complex (MIC - sector of social production, designed to provide security for the state in armed struggle. The core of the DIC were four industry: Commissariat of Aviation Industry (NCAP, the People’s Commissariat of ammunition (NBC weapons Commissariat (IEC and the People's Commissariat of the shipbuilding industry (NCSP, formed in accordance with the Decree of the Presidium of the Supreme Soviet on January 11, 1939 by separation of the People's Commissariat of Defense Industry of the USSR. They became a separate group of central government, designed to provide measures for the implementation of strategic decisions of the military and political leadership of the country. Objective assessment of commissariats effectiveness were the results of their operations in wartime. From this point of view it is necessary to ascertain performance of its mission - to supply front with modern means of warfare. Largely due to this fact, the Soviet Union won in serious confrontation with the military-industrial complex military industry of Nazi Germany and its satellites. On the basis of archival documents and testimony of contemporaries the article shows the contribution of the defense industry in the Soviet Union's victory in the Great Patriotic War.
Kallio, Alexis Anja; Partti, Heidi
In this article the author's examine, through the cases of Finland and Cambodia, expressions of constructive patriotism in educational policy, curriculum documents and music teacher actions and reflections. This study is part of a broader cross-cultural exchange project: "Multicultural Arts University", between researchers and music…
Busey, Christopher L.; Walker, Irenea
Extant conceptions of patriotism in social studies curricula are centered upon blind allegiance to the state or a belief in ideals of a liberal democracy. Yet these conceptions fail to account for the complex racial experiences that mediate citizenship and civic action, especially for Black persons. In this article, we advance a theory of Black…
Janmaat, Jan Germen; Mons, Nathalie
The literature on political socialization has overlooked the influence of system characteristics of schooling on civic values and youth political identities. This article addresses that gap by investigating the degree to which system differentiation relates to the values of ethnic tolerance and patriotism. We distinguish between pedagogical…
Cleland, Timothy James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kubicek, Deborah Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stroud, Phillip David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cuellar-Hengartner, Leticia [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mathis, Mark [Descartes Labs, Inc., Los Alamos, NM (United States)
This document provides an updated user guide for Patriot Script Version 1.0.13, for release with PEM 1.3.1 (LAUR-1422817) that adds description and instructions for the new excursion capability (see section 4.5.1).
This paper examines the British Labour government's developing political discourse on patriotism, citizenship and multiculturalism since 1997, particularly following the 2001 terrorist attacks in the United States and the 2005 London bombings. It focuses on the speeches of key government figures, notably Prime Ministers Tony Blair and Gordon…
Kissling, Mark T.
In the late 1930s several prominent self-described patriotic groups attacked social studies pioneer Harold Rugg as "un-American." The largest instance of textbook censorship in American history unfolded. Yet little attention was given (and continues to be given by scholars) to Rugg's elementary textbooks that he wrote with Louise…
a computer program which simulates the PATRIOT battalion UH1F communication system. *.-.The detailed description of how the model performs this...the Degree of Master of Science .AI . j tf ti on-i by 5 , .... . :it Lard/or Gregory H. Swanson DLt Captain USA Graduate Computer Science I...5 Model Application..... . . . .. .. . . .. .. . . 6 Thesnis Overviev ....... o.000000000000000000000. .6 Previous Studies
Full Text Available This case study discusses a youth branch of Matica slovenská, a pro-Slovak culture organization. It is based on in-depth research of the structure of the organization and it focuses on basic characteristics of functioning of this social movement such as funding, membership base, political orientation, civic engagement, patriotic activities and also the causes of negative media presentation. Presented material pointed to a thin boundary between the perception of positive manifestations of patriotism and at the same time negative (even extremist connotations of such manifestations in Slovak society. This duplicate perception of patriotic activities is reflected not only in polarization of opinion in society but also on the level of political, media and public communication. Thus, the article is a small probe from the scene of youth activism with an ambition to point out to such a diverse perception of patriotic organizations/activities in present-day Slovak society.
Владимир Михайлович Филиппов
Full Text Available Russian, Ukrainian and Belarusian peoples` (who has been considered fraternal for a long time representations of the modern world currently due to many factors are subjected to complex processes of transformation. So the importance of the historical period of the Great Patriotic War in the life of all three peoples, the memory of which has an important means of confrontation western propaganda, is certainly true. The article presents the results of the study of Russian, Ukrainian and Belarusian students’ and their parents’ representations of the Great Patriotic War. The study was being held in Peoples’ friendship University of Russia, immediately after the celebration of the 70th anniversary of the Great Victory.
Yurii V. Rubtsov
Full Text Available Article presents the archival materials included in album book "Tuva for the frontline” (Moscow, 2014. The publication edited by the Russian Minister of Defense S.K. Shoygu is a scientific popular source study. It contains a significant number of documents regarding the participation of Tuva in the Great Patriotic War of 1941-1945 specially revealed for this title by the Russian State Archive of Sociopolitical History and the Central Archive of Russian Ministry of Defense.
2013 and 2021 for Patriot Ongoing Upgrades to Address Obsolescence Issues 19 Figure 5: Fielding Schedule and Breakdown of Total $827.6 Million in...upgrade efforts. To conduct this review, GAO examined Army and program documents including test plans and schedules . GAO also interviewed Department...are intended to improve the system’s performance, reliability, and communications as well as address obsolescence and sustainment issues. The figure
Trotsuk Irina V.
Full Text Available Today there are diverse trends (such as government’s intervention into the private lives of people, reduction of state’s support and impact in the social sphere, and globalization that makes the world smaller that complicate the sociological study of patriotism in a ‘traditional’ way – as a value orientation ‘measured’ by simple questions about one’s knowledge, feelings, actions, and self-identification. Thus, it is necessary to identify several frameworks for the empirical study of patriotism. The first ‘dimension’ is traditional ‘patriotic mood’ – a set of stable cognitive, affective and behavioral value orientations. The second ‘dimension’ consists of different components of the social well-being associated primarily with the estimates of life in the country. The third ‘dimension’ consists of persistent stereotypes of the neighboring and other countries in the geopolitical context. The fourth ‘dimension’ is a result of the political decisions considering national security issues. Russia’s political leaders connect food trade to national security; therefore, ‘food insecurity’ is to a great extent manufactured for political reasons to bolster national security or (food nationalism.
Full Text Available Cosmopolitan liberals would be ready to fight - and to kill and be killed for the sake of restoring international justice or for the abolition of profoundly unjust political institutions. Patriots are ready to do the same for their own country. Sometimes the cosmopolitan liberals and patriots would fight on the same side and sometimes on the opposite sides of the conflict. Thus the former would join the latter in the defense of Serbia against Austria-Hungary (in 1914 but would oppose the white Southerner patriots in the American Civil War (in 1861. In this paper I argue that fighting and killing for one’s country is, in both of those cases, different from the defense of one’s own life and the lives of those who cannot defend themselves. Killing for one’s country is killing in order to fulfill a particular political preference. The same is the case with fighting for the abolition of a profoundly unjust political institution. It is not amoral or immoral to refuse to kill for any one of these two political preferences because there is no reason to believe that either political preference trumps our moral constraints against killing.
Full Text Available Purpose of the study was to estimate current state of quality of life of Great Patriotic War veterans. Materials and methods. The study included 368 veterans of the Great Patriotic War according to Federal State "Concerning veterans" #5, 1995. Protocol of the study included adapted fragments of WHOQOL, WHOQOL-Old, SF-36, SIP questioners as well as visually-analog scale of self-assessment of quality of life with further going quality of life index calculations. Re-sults. In the studied sample of the Great Patriotic War (GPW veterans including long-livers comparably was detected high level of quality of life (QOL by physical criteria and independence level. It was revealed that QOL by self-service criteria in the GPW veterans was low and extremely variable by other criteria groups. Both ageing and gender influenced upon physical activity, self-service and QOL self-assessment. Women were outstanding by psychological criteria and independence with no association with age group. Conclusion. QOL indication in the GPW veterans of studied sample elucidated a satisfactory level of healthcare in the region, which allows veterans in certain way preserve both physical and psychological health, as well as grounds positive self-assessment of personal position in society and values system according to their life-goals and expectations.
Full Text Available Quantitatively, this study intends to identify the attitude and perception of young audiences in Malaysia towards Independence day TV commercials from Petronas, and Maxis Berhad in celebrating the Independence Day. Firstly, respondents were exposed to three TV commercials with the same theme and purpose – to represent the spirit of patriotism. Later, these respondents were given a set of questionnaire to be filled. Data were collected using Purposive Sampling and analyzed with statistical analysis (SPSS using Descriptive analysis represented by using the value of percentages, X, and SD. Findings of this study revealed that respondents have negative attitudes towards independence day, but positive attitudes towards the patriotism showed in all TV commercials. They also showed positive perception on independence day television commercials, as high number of respondents have agreed that the concept, theme and art direction of television commercial about love and live in unity without racism will be the style of benchmark for the future style of direction towards producing television commercial for Independence Day and are considered vital to instill patriotism towards the nation.
Full Text Available Le patriotisme économique est généralement perçu comme une invitation faite aux acteurs économiques tels que l’État, les consommateurs ou les entreprises, à favoriser les activités nationales. L’objectif de cet article est de montrer que le patriotisme économique n’est pas seulement un instrument au service de la puissance industrielle et commerciale d’un État ou un vecteur de sa puissance financière, mais qu’il est aussi parfaitement compatible avec les dimensions sociale et environnementale du développement durable. Le concept de patriotisme économique, à cet égard, a été examiné dans ses logiques traditionnelles d’inspiration mercantiliste, listienne et keynésienne et revisité dans l’optique de la théorie du don, initiée par Marcel Mauss et dans celle de Durkheim.Economic patriotism is generally perceived as an invitation given to economic actors such as the State, consumers or companies, to facilitate national activities. The objective of this article is to show that economic patriotism is not only an instrument in the service of the industrial and commercial power of a State or a vector of its financial power, but that it is also perfectly compatible with the social and environmental dimensions of sustainable development. The concept of economic patriotism, in this respect, was examined in its traditional logics (Mercantilism, List and Keynes and revisited in the optics of the theory of gift, introduced by Marcel Mauss and in the optics of Durkheim.
Alexander Y. Borisov
From ancient times, war was called "the creator of all things". And winners created the postwar world order. The article reveals the backstage, the diplomatic history of the Great Patriotic War, which make the picture of the main events of the war, that culminated in victory May 1945 in the capital of the defeated Third Reich, complete. The decisive role of the Soviet Union and its armed forces in the defeat of Nazi Germany and its allies was the strong foundation on which to build the strate...
E. V. Fedorova
Full Text Available The article presents an analysis of the nationalism and patriotism phenomena in the system of normative and legal views of Russian philosopher, specialist in studying of law and state I.A. Ilyin. The author considers his characteristic of nationalism and patriotism in general, their specific nature and peculiarities in Russia, as well as analyzes their condition in post-Soviet period of its development and possibility of using I.A. Ilyin’s views and ideas on this issue as a source of spiritual, moral and national revival of modern Russian society.
Miroshnichenko Valentina Ivanovna
Full Text Available Purpose of the article is study of features value of physical perfection and tempering as a constituent of introduction of Cossack pedagogics in patriotic education of border students-guards. Material for writing of the article was experience of lead through of the noted measures in terms an academy. As a result of creative introduction in the conditions of educational-educate future border officers-guards acquire the process of higher military educational establishment of Cossack traditions and consuetude physical health, moral cleanness and spiritual wealth, develop patriotic qualities.
Full Text Available The article draws attention to the problem of self-proclaimed “patriotic” groups, which in Slovenia use patriotism to legitimize intolerant nationalist and racist as well as homophobic rhetoric and action. It is a case study of the “patriotic” groups entitled Here is Slovenia, which serves to highlight the connection between patriotism, nationalism and racism. This movement is characterized by its strong emphasis on young people, to whom Here is Slovenia speaks through a variety of programs, campaigns and socializing events. The article situates this case in discussions of nationalist and racist tendencies that enable the promotion of intolerant and hateful messages based on a primordial understanding of the nation as a homogeneous ethno-cultural community. Symbols, ideology, discourse and operation of the project Here is Slovenia are analyzed by examining the group's history and overview of its main activities, exposing the role of the Internet and social networks, in particular Facebook. The paper complements this with an analysis of interviews with (former members and supporters, whose narratives allow a rare insight into the thinking that otherwise remains outside dominant discursive practices.
Ameerika Vabadussamba saamisest. Autoriks oli noor Elsassi arhitekt Frederic-Auguste Bartholdi. Metallkarkassi konstrueeris insener Gustave Eiffel. Kuju sai valmis ja kingiti Prantsusmaa poolt Ameerikale 1884. a. Vabadussammas avati 1886. a.
The article deals with the task solutions on life and health preservation of children during the Great patriotic war and Leningrad blockade. The examples are presented illustrating the measures undertaken by the state and public health service concerning the evacuation, nutrition of children in conditions of strict deficiency of all food products, organization of medical care (including the development and implementation of new system of polyclinic care), the activities on health improvement of children, etc. The long-term qualitative and quantitative starvation of children adversely impacted the physical development, contributed to increased morbidity and mortality. The characteristic of children morbidity is given? Infectious morbidity included. The role of researchers from Leningrad pediatric medical institute in preservation of children's life is demonstrated.
Marcela García Sebastiani
Full Text Available During the first third of the 20th century, Spanish migrants in Argentina prompted, from specific areas of civil society and the public sphere, corporate identity for political purposes. It was a residual patriotism and condemned from the outset. It was activated in specific circumstances and in relation to the local policies projected towards the collective migratory, the Spanish politics, and recognition of shared sociopolitical and cultural genealogies. From the perspective of cultural history of the policy, and based on primary and secondary sources, this article discusses about built imaginaries, social mobilization generated and results between 1885 and 1920. During that time, from distance, migrants also built ideas about Spain and drawn up national myths in the cultural version of liberalism that eventually led to a conservative nationalist, catholic and –at times– fascist.
Ersner-Hershfield, Hal; Galinsky, Adam D; Kray, Laura J; King, Brayden G
Four studies examined the relationship between counterfactual origins--thoughts about how the beginning of organizations, countries, and social connections might have turned out differently--and increased feelings of commitment to those institutions and connections. Study 1 found that counterfactually reflecting on the origins of one's country increases patriotism. Study 2 extended this finding to organizational commitment and examined the mediating role of poignancy. Study 3 found that counterfactual reflection boosts organizational commitment even beyond the effects of other commitment-enhancing appeals and that perceptions of fate mediate the positive effect of counterfactual origins on commitment. Finally, Study 4 temporally separated the counterfactual manipulation from a behavioral measure of commitment and found that counterfactual reflection predicted whether participants e-mailed social contacts 2 weeks later. The robust relationship between counterfactual origins and commitment was found across a wide range of companies and countries, with undergraduates and M.B.A. students, and for attitudes and behaviors.
Full Text Available The article provides evidence on participation of assistants who worked at the Department of Human Anatomy of Saratov State Medical University n.a. V. I. Razumovsky and took part in the Great Patriotic War.
Full Text Available Economic, political and militaristic tensions between countries are present throughout the world. The devastating effects of the global financial crisis are still generating the ever-increasing instability of the world economy. Patriotism and nationalism, as well as animosity towards the economic and military policies of certain foreign countries, seem to be on the rise across many countries and nations in recent years. It is precisely the current situation in the world that is favorable for encouraging citizens to purchase domestic products. The policy can be particularly useful for less-developed import-oriented economies. Thus, in the conditions of the economic crisis, the study of consumer ethnocentrism is gaining in importance. The paper examines the effects of the patriotism of the citizens of the Republic of Serbia and animosity towards the EU on consumer ethnocentrism. The results show that both these variables stand out as the statistically significant antecedents of consumer ethnocentrism; however, it should be noticed that patriotism shows a stronger influence on the consumer’s orientation towards buying domestic products. The research findings indicate that love of one’s country may direct consumer choices towards domestic brands, despite the positive image and high quality of foreign ones. In addition, due to citizens’ strong dislike towards the EU economic policy, some of them may decide to buy lower-quality domestic products; however, this does not necessarily negatively affect one’s perception of foreign products.
Muhamad Farhang Muzzafar
Full Text Available Children’s literature, despite being a relatively young branch of literature in general, is an important factor in the upbringing of children. Its basic aims have been obvious but not simple to achieve – to develop a child’s personality, provide educational experiences and encourage him to read. Along with areas such as art, theater, puppetry, music, movement and field trips, literature is also an object of children’s attention. Moreover it provides an opportunity to gain experience and learn a lesson, as children are usually open to fairytale-like content. Because of that, a magic world of adventures usually becomes a part of the educational process, imparting moral patterns and exposing them to various experiences, values and attitudes. Listening to stories told by parents, nannies, and teachers, which are later read by children themselves, is an activity beloved by children from all over the world. This research focuses especially on Kurdish experiences in terms of children’s literature and its role in bringing up a child. It indicates essential differences between contents, aims and circumstances upon which certain stories occurred. It provides an explanation of their role in developing a mature personality and patriotism41 upbringing among Kurdish children.
Brázdil, Rudolf; Bělínová, Monika; Rožnovský, Jaroslav
Scholarly and economic management societies played an important role in the beginnings of meteorological observations in Central Europe. In Bohemia, one such was the "Imperial Royal Patriotic-Economic Society of Bohemia" which, as well as making meteorological observations, organised a network of phenological stations and published the results of their observations from 1828 to 1847. The phenological observations covered 31 different forest plants, fruit trees and field-crops. Some of the phenological stations continued to make observations within the network of the Central Institute for Meteorology and Earth Magnetism established in Vienna in 1851. Analysis of the above observations led to the collation of information on the temporal and spatial distribution of the observed phenological characteristics (beginning of budding and/or foliage, beginning and end of flowering, ripeness of seeds and fruits) in the 1828-1847 period, which was cooler and generally wetter with respect to more recent temperature and precipitation patterns (1961-1990) in the study area. Phenophases of flowering and ripeness for selected plants are presented for the Hradec Králové and Loket stations, showing late onsets in this period in comparison with recent phenological stations located nearby and taking measurements in 1993-2009. Working up this topic makes a contribution to the historical phenology of the nineteenth century in the Czech Lands and in Central Europe as well.
Potemkina Marina Nikolaevna
Full Text Available The paper is devoted to the role of the railway transport in migration from the frontline to the Soviet rear during the Great Patriotic War. The research is based on the analysis of the published and archival documents, personal diaries, letters, memoirs, texts of interview with the people who lived through the evacuation. The methodological foundation of the research was based on the theoretical principles made by the Everyday History. Surge attack of the German troops and cruel occupational policy caused the necessity of evacuation of civilians to the Eastern regions of the country. The evacuation was both spontaneous and organized and helped to save millions of human lives. The lack of evacuation plans in case of a war, incompleteness of the railway transport renovation, transport routes destroyed by the enemy and the stream of refugees were among the main factors which complicated evacuation process. The conditions of transportation differed according to the time and the circumstances of the evacuation and a person’s position in social hierarchy. There were some problems during the evacuation, such as regulation of the rail service, sanitation of the carriages, nutrition system, psychological shock. People had to spend weeks in the carriages suffering from cold, hunger and diseases. During the evacuation a new alternative reality appeared with its rules and regulations which changed the concepts of tangible assets and moral values. The priority for any person was to survive, which meant to be independent and to do everything possible.
Full Text Available This article examines the efforts and achievements of Oen Boen Ing, a Tionghoa doctor, to improve the quality of health of the poorer inhabitants of Surakarta. Dr Oen played an important role in five different periods: Dutch colonialism, the Japanese occupation, the Indonesian revolution, Soekarno’s regime, and Suharto’s New Order. Known for being a benevolent doctor, activist, and patriot of the revolution during his life-time, Dr Oen also gave medical assistance to the needy, which famously earned him the accolade of “doctor of the poor”. During the Indonesian revolution, Dr Oen assisted the Student Soldiers (Tentara Pelajar and afterwards was appointed the member of Supreme Advisory Council (Dewan Pertimbangan Agung/DPA by Soekarno in 1949. As a benevolent doctor and activist, Dr Oen is remembered for founding the Panti Kosala Hospital which was renamed to perpetuate his name on 30 October 1983, exactly a year after his passing. When he died, thousands of peoples gathered to pay their final respects to the doctor. He was honoured with a ceremony conducted in the Mangkunegaran Palace. Dr Oen’s name will be eternally respected, especially in Surakarta.
Ageeva Valentina Anatolyevna
Full Text Available The appearance of new conceptual approaches and trends in modern historiography, changing the contents and the source base on the history of the Great Patriotic War created new opportunities for the study of the history of everyday life, the “human dimension” of the war. As part of the article the war daily life is considered through the prism of one of the stories of the children’s and teenagers’ life in militarized space – the reality of consolidated pastime. Daily practice of this social category is the least studied in the historical literature. Leisure activities occupied a significant place in the structure of everyday life of children and teenagers during the war. Its organization both for military and peacetime was formally regulated along with informal and personal time. Changes in the structure and filling the free time of students in a militarized space appeared in the content and the intensity of certain forms of leisure time, destructive tendencies, limited material and time resources. The greatest amount of free time of the younger generation was in the informal, unregulated practice of leisure, the solution of domestic problems and housework. Due to objective circumstances of the wartime the role of the family, educational, cultural and entertainment establishments in the life of children and adolescents significantly fell. Thus, during the war a street became the center of their “leisure routine,” including asocial orientation. Free time proceeded among coevals; there was a formation of personality and values. Partly the formal structures responsible for leisure activities of students, in particular, hobby clubs, is a tool for their inclusion in the process of providing possible assistance for front and rear and give them the skills necessary in combat. At the same time unauthorized, individual leisure had a relaxing effect contributed to the displacement of negative emotions, lifting the state of anxiety and fear
И С Тряхов
Full Text Available In the hierarchy of human needs, food takes ﬁ rst place. Therefore the relevance of this topic during the intransient shocks. The article discusses the complexity of the food problem during the Great Patriotic War (on materials of the Vladimir region. The author examines the strategies for solving the food problem, the inhabitants of which were used in the edge of the war years. The material for the study is based on documentary sources of local supplies and memoirs of contemporaries. The author has reviled that supply of urban population with food conducted by cards, and all the inhabitants were divided into categories with different supplies. The card system is not fully secure the large mass of the population needs in food, but because they had to look for different ways of obtaining additional products. Special attention is paid to the creation of individual farms residents and farms businesses that became essential for survival of the people of that time. The study of the problem historian draws attention to other ways to ensure yourself of food the population of the region. These include assistance for the inhabitants of the cities from rural relatives, exchange things for food and work in the collective farms, that is a tempo-rary move from the city to the countryside. It was a process of reverse trend to mobilize the So-viet authorities on youth enterprise in the city. Permanent deterioration of the food situation in the war years becoming a signiﬁ cant part of the population on the brink of survival. The author has come to the conclusion that the country’s leadership could only provide a minimum level of survival for people with any serious deterioration of the situation at the front could lead to the most dramatic consequences in the rear.
Alexander Y. Borisov
Full Text Available From ancient times, war was called "the creator of all things". And winners created the postwar world order. The article reveals the backstage, the diplomatic history of the Great Patriotic War, which make the picture of the main events of the war, that culminated in victory May 1945 in the capital of the defeated Third Reich, complete. The decisive role of the Soviet Union and its armed forces in the defeat of Nazi Germany and its allies was the strong foundation on which to build the strategy and tactics of Soviet diplomacy during the war. It was implemented in the course of negotiations with the Western Allies - the United States and Britain, led by President Roosevelt and Prime Minister Churchill. World history teaches, large and small wars have been fought on Earth for centuries for specific political interests. In this context, the Second World War has been a shining example not only to curb the aggressor states, the liberation of peoples from the Nazi tyranny, but also an attempt by the victor to organize a new, better postwar world order to guarantee a durable and lasting peace based on the cooperation of the allied states. But the allies in the war did not become allies in the organization of the postwar world. Their collaboration briefly survived the end of hostilities and was overshadowed start turning to the Cold War. It was largely due to the US desire to realize their material advantages to the detriment of the Soviet Union after the war and build a system that would be a one-sided expression of the interests of Washington. Americans, especially after the death of President Roosevelt, and during his successor Truman understood international cooperation as an assertion of its global leadership while ignoring the interests of the Soviet Union, which bore the brunt of the war.
Brittany L. Roberts
Full Text Available When the Japanese attacked Pearl Harbor on the morning of December 7, 1941, they little realized what a formidable foe they had aroused. An enraged America immediately declared war on Japan. As a result, Germany declared war on America. Now facing enemies on both fronts, America mobilized her troops for action and prepared weapons of mass destruction. The unity experienced by the American people during this time had never been and would never be matched. Both soldiers and civilians launched themselves into the war effort. This great national endeavor called for anthems of reflection and encouragement. While they continued to sing national favorites such as "The Star-Spangled Banner" and "America the Beautiful," contemporary musicians wrote pieces that directly pertained to the country’s present trials and triumphs. New works remembering Pearl Harbor, praising the soldiers and comforting the sweethearts saturated the airwaves and were featured in performance venues. Music gave a tangibility and expression to the deeply felt emotional turmoil of the American people. They identified with and drew comfort from the subject matters it explored. Musicians such as Artie Shaw, Glenn Miller and the Andrews Sisters took tours entertaining troops at home and abroad, giving them courage and strength for the daunting fight they faced. When victory was finally achieved for the Allies on September 2, 1945, the people again turned to music as an outlet for their jubilant celebrations. Thus, music played a significant part in boosting American patriotism and troop support throughout the entirety of World War II.
Федор Леонидович Синицын
Full Text Available In the article the author analyzes the main aspects of the Nazi government ethnic policy implemented on the occupied territory of the Soviet Union during the first stage of the Great Patriotic War (June 1941 - November 1942 in the «civic» sphere (local administering, regulating ethno-cultural activities, mobilizing labor force, etc.. The authour shows the peculiarities of using the «ethnic factor» by Nazi occupants, and identifies its main trends, including promotion of nationalism, separatism, and russophobia, as well as the contradictions of the Nazi policies in the matter of granting self-government to the peoples of the Soviet Union.
Yuliya A. Davidova
Full Text Available A dynamics of the number of medical personnel Siberian cities in the Great Patriotic war is analyzed in the article. The author studies quantity and structure of senior and low-grade medical personnel of healthcare institutions, shows its impact on medical and sanitarian anti-epidemic work, as well as considers methods of decision of personnel problem in the region. The study is based on analysis of documents of the State Archive of the Russian Federation, the Russian State Archive of Socio-Political History, the Russian State Archive of Economy and the Regional Archives of the Siberian cities.
Rosemary Vieira; Jefferson Cardia Simões
Neste trabalho são descritas e analisadas as geoformas glacialmente modificadas dos montes Patriot e Independence, as quais se erguem sobre a superfície do manto de gelo da Antártica Ocidental, e os processos nelas atuantes associados à dinâmica do manto de gelo. Investigações de campo foram realizadas durante a Expedição Deserto de Cristal, no verão de 2008/2009. Dois conjuntos de geoformas foram identificadas e são associados às variações do manto de gelo da Antártica Ocidental: (a) geleira...
Full Text Available Estonian knowledge of history emanates from the fact that constituting an independent nation has for the most part been nothing but a utopia, and was a reality for a relatively short time. When it comes to selfidentification though, the expression ’a singing people’ is often used by the Estonians to describe themselves. Nostalgia for freedom is reflected in the Estonian culture of almost all periods and is carried on by the singing tradition, where patriotic songs emerge independent of different musical tastes within a particular generation and form an important part of a common Estonian repertoire. Patriotic songs occupy a central place in several fields of Estonian culture: besides music culture also in popular culture,and literary history – the works of poetry which have gained the most popularity are those which when put to music have been the most widely spread among the people. The main part of the most popular Estonian patriotic songs are choral songs from the national awakening at the end of the 19th century. Despite the national programmes aiming to wipe out ‘bourgeois nationalism’, they were sung at the song festivals in the Soviet era and were published in song books, expressing the people’s nostalgia for freedom lost. After the end of the Second World War, there was an attempt at launching a kind of patriotic new creation, where patriotism was merged with Soviet pathos; the aim was to show that the people’s utopia was in fact communism, but not a single one of those songs made it into the people’s common repertoire. Only the patriotic songs composed in the 1980s during the so-called new national awakening reached a popularity comparable to that of the old songs. The discourse on ’Estonianness’ and the shaping of a matching repertoire under imperial Russian rule took place under very different circumstances than its preservation and development in the second half of the 20th century under Soviet occupation, but
...(b) of the USA Patriot Act and 31 CFR 103.110 A Appendix A to Subpart H of Part 103 Money and Finance: Treasury Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND... Activity App. A, Subpt. H, Pt. 103 Appendix A to Subpart H of Part 103—Notice for Purposes of Subsection...
... 314(b) of the USA Patriot Act and 31 CFR 103.110 B Appendix B to Part 103 Money and Finance: Treasury Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS Pt. 103, App. B Appendix B to Part 103—Certification for Purposes of Section 314(b) of the USA...
Les compositions mémorielles autour de la Guerre patriotique. L’exemple du souvenir de Moussa Djalil, Tatar, stalinien, poète et patriote Memory Schemes Around the Patriotic War. The Example of the Memory of Musa Dzhalil, Tatar, Stalinist, Poet and Patriot
Full Text Available This article proposes to study the memorial destiny of Musa Dzhalil, a Tatar poet well-known in Russia for his Moabit Notebook written in the Berlin prison where he died in 1944. After 1956, he became posthumously an official Hero of the Soviet Union and won the Lenin Prize for his work. His popularity survived the disappearance of the USSR and Musa Dzhalil is still a popular figure in Russia today. This popularity is the result of a complex combination of factors : he is celebrated as a great patriot (for his military exploit in Germany but also as a representative of the Tatar culture (he wrote his work in Tatar, as an artist (his poems were translated into Russian and, last but not least, as a representative of the Soviet society (of the Stalinist period. Because of the mixing of these different components, the cult of Musa Dzhalil can be appropriated simultaneously by different groups in Post-Soviet society (Russian leadership, Tatar authorities, Communist Party, Cultural institutions. This complex combination of supports forbids any critical assessment of Dzhalil’s memory. Critics against him are immediately denounced as anti-Tatar, anti-Soviet, anti-cultural and anti-Russian. This paper thus shows, through the example of Musa Dzhalil, the insertion of Great Patriotic War memory in a complex collection of social and political bonds.
Full Text Available Independence Day and Land of Plenty are two tropes referring to the basis of American national identity: the Declaration of Independence with its guarantee of equal and inalienable rights and the promise of an inexhaustible abundance of resources. Independence Day and Land of Plenty are also two American feature films directed by German émigrés, the first being a science fiction blockbuster from 1996 by Roland Emmerich, the second an independent road movie from 2003 by Wim Wenders. Both films confront the issue of American patriotism albeit from different angles and at different times. Independence Day wholeheartedly embraces the American founding myths and translates them into a science fiction scenario. Wenders manoeuvres into an artistic space producing what I call patriotism of dissent. The films engage in a kind of dialectic dialogue on American patriotism. This article takes a close look at émigré perspectives on American patriotism before and after 9/11. By turning to the four patterns which political theorist Samuel P. Huntington identified as possible responses to the discrepancy between principles and practices of American democracy, I will analyse Independence Day as a filmic strategy to deny democratic gaps and Land of Plenty as a representative example of a moralistic reaction to democratic gaps. In the discourse of screening American patriotism from German émigré perspectives before and after 9/11, the work of Emmerich and Wenders exemplifies the spectrum of approaches to negotiate the fantasy of, desire for, and experience of American culture in the medium of film.
Kosachev, I D; Gladkikh, P F; Iakovlev, A E
The article is devoted to activities in the period 1941-1945. Krasnoyarsk and Tambov, a professor of surgery Valentine Feliksovich Voyno-Yasenetsky (Archbishop Luka)--doctor of medical sciences, laureate of the State (Stalin) Prize of the USSR, who made a significant contribution to the success of modern surgical science. A brilliant scholar and successor of the ideas of the outstanding scientist and surgeon Nikolai Pirogov, as in the Great Patriotic War surgeon and consultant evacuation hospitals, along with leading surgeons in the Soviet Union had a significant impact on the results of treatment of wounded soldiers and officers, thereby affecting the development of military field surgery. In our country it is rightfully considered the founder of contaminated surgery.
Nadezhda V. Tarasova
Full Text Available The article is concerned with the problem of civil and patriotic education of students by means of voluntary activity, presents historical and educational analysis of excursion activities as one of the major forms of volunteer work of schoolchildren in Russia in the second half of the XIX – early XX centuries, determines its major goals and objectives. The paper, using archive data, attempts to consider excursion activity as one of the major forms of volunteer work, promoting patriotism development in rising generation. The opinions of innovative teachers of the examined period, who considered that excursions had great educational potential are characterized. The position of the Ministry of Education, concerning educational potential of excursions is examined.
Shelepov, A M; Ishutin, O S; Leonik, S I
This article evaluates military and political situation in the world and operational-strategic environment on the West Theater of operations on the eve of the Great Patriotic War (1941-1945). We analyze structure and overall condition of sanitary service of West Special Military District of the Workers and Peasants Red Army and causes of failure of mobilization, organization and deployment of military units and establishments from the beginning of aggression of Fascist Germany to the Soviet Union.
Full Text Available Neste trabalho são descritas e analisadas as geoformas glacialmente modificadas dos montes Patriot e Independence, as quais se erguem sobre a superfície do manto de gelo da Antártica Ocidental, e os processos nelas atuantes associados à dinâmica do manto de gelo. Investigações de campo foram realizadas durante a Expedição Deserto de Cristal, no verão de 2008/2009. Dois conjuntos de geoformas foram identificadas e são associados às variações do manto de gelo da Antártica Ocidental: (a geleiras de rochas e feições periglaciais associadas de gelo-rocha (RIFs – Rock-Ice Features; (b morainas supraglaciais (supraglacial moraines e morainas de gelo azul (blue-ice moraines. As feições deposicionais dominantes nos montes Patriot e Independence envolvem dois processos: (1 atividades de vertentes que proporcionam abundante material supraglacial; (2 detrito basal e englacial que alcançam a superfície do gelo, quando esta é rebaixada pela ablação, tais detritos ficam expostos. Proeminentes morainas de núcleo de gelo formam cordões de quilômetros de extensão e dezenas de metros de largura. Os cordões morâinicos mais próximos às paredes rochosas, em especial, nos montes Independence, sofrem também a influência do material das vertentes, remobilizando assim os depósitos originais. Nos cordões morâinicos mais externos os detritos alcançam a superfície por ablação ou por movimentos ascendentes do gelo, com pouco movimento pós-deposicional. Os processos de sublimação do gelo são frequentes na superfície das geleiras e das morainas, produzindo uma superfície irregular. A radiação solar e a ação do vento também podem contribuir para a ablação em alguns pontos das morainas.
Aldyn-ool K. Kanzay
Full Text Available The article examines the main directions, forms and methods of work used by Revolutionary Party organs and non-governmental organizations of the People’s Republic of Tuva (PRT which helped ensure the participation of Tuvans in the Great Patriotic war of the USSR (WWII. To describe the forms and types of support the people of Tuva gave to the Soviet Union in its fight against the Nazi invaders, the author provides facts, statistics and quotations from Tuvan statesmen. These pieces of data come from both academically published sources and those found in the Central State Archives of the Republic of Tuva. The steps and measures initiated by the Revolutionary Party include the program of wartime rebuilding of the economy (adopted at the 2nd plenum of the Central Committee of Tuvan National Revolutionary Party (CC TNRP, June 26, 1941; plans of mass production of skis and warm clothes for the Red Army, of an increase in livestock and crop field areas, of enhancing competitive work and introducing ‘shock work’ practices (adopted at 3rd Plenum of CC TNRP, December 22, 1941; the resolution on the readiness to enlist Tuvan youth in the Red Army, adopted by the 3rd session of the PRT’s Small Khural, February 17, 1942; the joint order by the Cabinet of Ministers of PRT and the CC TNRP to set up a system of war training for the citizens of PRT and a national militia, adopted in July 1942; etc. The war years gave rise to a lot of grassroots initiatives of supporting the USSR, the most massive and fruitful among them being the movement to raise the money for the USSR’s Defense Fund. Donations included money transfers, providing spoils of the chase and livestock to the collective farms of Ukraine, and wheat and millet, to the Defense Fund. Among the donors were schools, Revolutionary Youth cells and private individuals. Mobilization in Tuva was accompanied by dedicated everyday organizational, explanatory and agitational work of the organs of the
The Financial-Organizational Foundations of Assessment and Comparison of Scientific-Publication Activity of the Employees of Scientific Sphere in Terms of the Paradigm of the Public-Creative Patriotism of Nation
Karpinsky Borys A.
Full Text Available The article is aimed at allocating both the specific features of financing the scientific sphere of Ukraine in the current period of transformation and the reform of sectors of the national economy, as well as the development of financial-organizational foundations of assessment and comparison of scientific-publication activity of the employees through conformity of the occupied position, proceeding from the paradigm of public-creative patriotism of nation. It has been proved that, in its fundamental essence, the paradigm of public-creative patriotism of nation is manifested and materialized through the physical participation of every citizen in formation of the own state, and is most fully implemented in the simultaneous interaction of individual dominants of such a patriotism: qualitative and quantitative (tax. A characteristic manifestation of such a patriotism in the scientific sphere is the increase of productivity of scholars on the basis of scientific-publication activity, which was for the first time suggested to be assessed on the basis of the Hirsch index for employees in view of the hold position with the relevant rating. The financial-organizational foundations of assessment and comparison of the public-creative patriotism of both the scientific and the teaching staff, allowing to increase potential of scientific sphere of the State in the context of basics of behavioral economics, have been substantiated.
Department issued its final section 311 rule on BDA on 19 March 2007 “to help en - sure that Banco Delta Asia is denied access to the US financial system...located in China’s Macau Special Administrative Region, Banco Delta Asia (BDA), is the best known and perhaps the most misunder- stood. In September...BDA facilitated this illicit behavior—which included distributing counterfeit US currency, smuggling black market tobacco products, and drug
Tuch, Boris, 1946-
Sõpruse kinos on 20.-25. oktoobrini filmiprogramm "Vabaduse tuuled" Ungari 1956.a. ülestõusule pühendatud mängufilmide programm (6 ungari filmi aastaist 1965-2004) : Ungari Instituudi, kino "Sõprus" ja PÖFFi koostööprojekt
Eestis töötava rootsi fotograafi Sven-Olof Englundi (pseud. Svenne) mootorrattureid ja nende rattaid jäädvustav fotonäitus Tallinna kohvikus Cafe VS. Näituse avamisel osalesid motoklubi Road Spirit MC liikmed
Tallinna Vabadussamba kavandi avalik arutelu Rahvusraamatukogus. Kavandi autorid Andri Laidre ja Rainer Sternfeld neile osaks saanud kriitikast ja vabadussamba materjalina kasutatava klaasi tugevusest
Full Text Available The promoting of a patriotic cinema by the Russian state favored a new production, which appropriates in various ways this topos of the Soviet cinéma which is the patriotic Great War. The variety of the films is actually coupled with a big heterogeneousness of the reactions of the public; therefore the analysis of the comments of the Internet users allows to identify several fractures as for the representation of the war and for the expectations of the spectators. This study illustrates the lack of consensus around the war, it allows to seize the modulations and inflections of the patriotic theme and to understand the indignation, that met Mikhalkov's film Burnt by the Sun 2.
Full Text Available The southern coast of the Gulf of Maine in the United States is prone to flooding caused by nor'easters. A state-of-the-art fully-coupled model, the Simulating WAves Nearshore (SWAN model with unstructured grids and the ADvanced CIRCulation (ADCIRC model, was used to study the hydrodynamic response in the Gulf of Maine during the Patriot's Day storm of 2007, a notable example of nor'easters in this area. The model predictions agree well with the observed tide-surges and waves during this storm event. Waves and circulation in the Gulf of Maine were analyzed. The Georges Bank plays an important role in dissipating wave energy through the bottom friction when waves propagate over the bank from offshore to the inner gulf due to its shallow bathymetry. Wave energy dissipation results in decreasing significant wave height (SWH in the cross-bank direction and wave radiation stress gradient, which in turn induces changes in currents. While the tidal currents are dominant over the Georges Bank and in the Bay of Fundy, the residual currents generated by the meteorological forcing and waves are significant over the Georges Bank and in the coastal area and can reach 0.3 m/s and 0.2 m/s, respectively. In the vicinity of the coast, the longshore current generated by the surface wind stress and wave radiation stress acting parallel to the coastline is inversely proportional to the water depth and will eventually be limited by the bottom friction. The storm surge level reaches 0.8 m along the western periphery of the Gulf of Maine while the wave set-up due to radiation stress variation reaches 0.2 m. Therefore, it is significant to coastal flooding.
Full Text Available The aim of a 3-year study was to compare the effect of substrate type (peat, sawdust and cocoa husk on the yield, fruit quality, general and phenolic composition, and antioxidant activity of highbush blueberry (Vaccinium corymbosum L. cultivar Patriot. The largest berries and the highest yield were obtained from bushes grown in sawdust (3.661 kg ha-1. Berries from bushes grown in cocoa husk had the highest content of N (14.25 g kg-1, P (1.17 g kg-1, K (6.51 g kg-1, and Zn (8.78 mg kg-1, as well as P (1.26 g kg-1 and K (6.99 g kg-1 in the leaves. Both the leaves and fruits of plants grown in sawdust had higher Cu concentrations (3.89 and 3.01 mg kg-1. Berries from sawdust-grown bushes had the highest soluble solids (13.1% and total sugar (10.80 g 100 g-1 content. The fruits obtained from peat-grown bushes exhibited enhanced antioxidant capacity (38.6 ìmol Trolox g-1. However, the highest levels of phenolics were noted in berries produced in the cocoa husk (208.29 mg 100 g-1 and peat-bed system (174.07 mg 100 g-1. Regardless of the type of substrate used, the following phenols were identified (in descending order: anthocyanins>chlorogenic acid>flavonols. Delphinidin-glycosides were the most abundant pigments, and cyanidin, peonidin, petunidin, and malvidin-glycosides were also detected. Total flavonol content (quercetin derivatives and kaempferol 3-rutinoside was not significantly affected by the type of substrate.;
Sterkhov Dmitry Vladimirovich
Full Text Available The article touches upon the impact of the religion on the national consciousness of European nations in the 19th century. As an example of this impact can serve the sermons of the German protestant clergy dedicated to the victory of the German and Allied troops over Napoleon armies in the Battle of Leipzig on 16–19 October, 1813. On the battlefield of Leipzig there emerged a very powerful national myth, partly created by means of the patriotic preaching of German pastors. This myth of Leipzig, propagandized by the protestant clergy, consisted of several components; one of them was the popular idea of “God’s Judgment” which was imposed by God on Napoleon and the French nation. The salvation of Germany was thus explained by God’s direct intervention in the Liberation Wars against France. The pastors create a dark and unattractive image of Napoleon who is exposed as tyrant, theomachist and even Antichrist. Not less negative is the image of the French who are described in the sermons as unreligious and immoral. Their direct opposites are the Germans whom the protestant preachers endow with such qualities as piety and morality. In the eyes of the pastors the Germans constitute a single nation united by common features, such as the German language, the German traditions and the German religiousness. As considerable national symbols in the sermons appear the German national heroes such as Martin Luther, the Swedish King Gustav Adolph and the most notable hero Hermann, the leader of one of the ancient German tribes. Consequently the French are compared with ancient Romans who overindulged in sins and immorality and were defeated by the brave Germans with the help of God. As a result the German protestant clergy contribute to the creating of the myth of Leipzig which became a considerable symbol of the German national history.
Sun, Jiufeng; Wu, De; Zhong, Haojie; Guan, Dawei; Zhang, Huan; Tan, Qiqi; Zhou, Huiqiong; Zhang, Meng; Ning, Dan; Zhang, Baohuan; Ke, Changwen; Song, Tie; Lin, Jinyan; Zhang, Yonghui; Koopmans, Marion; Gao, George F
Fast expansion and linkage to microcephaly and Guillain Barre syndrome have made Zika virus (ZIKV) track attention of global health authority concerns. The epidemiology, virological characteristics and genetic evolution of introduced ZIKV to Guangdong, China, were investigated. Analyses of the epidemiological characteristics and genetic diversity of ZIKV isolates were performed. A total of twenty-eight confirmed ZIKV infection cases were imported into China in 2016, of which 19 were imported into Guangdong, China from Venezuela (16), the Samoa Islands (1), Suriname (1) and Guatemala (1). Serial sampling studies of the cases indicated longer shedding times of ZIKV particles from urine and saliva samples than from serum and conjunctiva swab samples. Seven ZIKV strains were successfully isolated from serum, urine and conjunctiva swab samples using cell culture and neonatal mouse injection methods. Genomic analysis indicated that all viruses belonged to the Asian lineage but had different evolutionary transmission routes with different geographic origins. The molecular clock phylogenetic analysis of the ZIKV genomes indicated independent local transmission that appeared to have been previously established in Venezuela and Samoa. Additionally, we found 7 unique non-synonymous mutations in the genomes of ZIKV that were imported to China. The mutations may indicate that ZIKV has undergone independent evolutionary history not caused by sudden adaptation to Chinese hosts. The increasing number of ex-patriot Chinese returning from ZIKV hyper-endemic areas to Guangdong combined with the presence of a variety of Aedes species indicate the potential for autochthonous transmission of ZIKV in Guangdong. Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Full Text Available The article is devoted to the study of V. Zagorschi’s cantata „Under the Banner of Victories” (1952, as a landmark work for his period — the 50s of the 20th century, as well as for the composer’s subsequent creation. The cantata serves as an embodiment of the heroic-patriotic themes, being, at the same time, one of the samples of the „occasional” compositions in the works of the composers from the Republic of Moldova. In the process of analyzing the cantata, its musical features are revealed, reflecting the artistic orientations of their time.
Full Text Available The article deals with the development of the youth athletic and sports movement in the Penza region in the first half of 1941 – before the Great Patriotic War. The activities of local Soviet-party and public organizations for the health improvement and military sport training of the population, especially the young: mass ski trips and crosses, gymnastics competitions, athletic crosses (for the Day of the Bolshevik Press, of Komsomol-trade union, for the prize of the "Young Leninist" newspaper, etc..
Dmitrii A. Malyutin
Full Text Available The paper presents the review of the collection of documents, including the data on social and economic situation in Krasnoyarsk Region during the Great Patriotic War, the activity of party and Soviet authorities, deeds by Krasnoyarsk natives in the frontline and labor achievements in the rear. The collection contains the documents, describing the daily life in wartime, the public mood, the living conditions, social security, the status of disabled veterans. The presented data, concerning patriotic activity of the orthodox church, camps of People's Commissariat for Internal Affairs, facts of desertion, speculation, criminality in the region prove weight and objective approach of the composite author to the documents selection.
Сергей Игоревич Белов
Full Text Available The presented work is devoted to the study of the practice of using computer games as a tool of the memory policy. The relevance of this study determines both the growth of the importance of video games as a means of forming ideas about the events of the past, and a low degree of study of this topic. As the goal of the author's research, the research is to identify the prospects for using computer games as an instrument for implementing the memory policy within the framework of the case of the events of the Great Patriotic War. The empirical base of the work was formed due to the generalization of the content of such video games as “Call of Duty 1”, “Call of Duty 14: WWII”, “Company of Heroes 2” and “Commandos 3: Destination Berlin”. The methodological base of the research is formed due to the involvement of elements of descriptive political analysis, the theory of operant conditioning B.F. Skinner and the concept of social identity H. Tajfel and J. Turner. The author comes to the conclusion that familiarization of users with the designated games contributes to the consolidation in the minds of users of negative stereotypes regarding the participation of the Red Army in the Great Patriotic War. The process of integration of negative images is carried out using the methods of operant conditioning. The integration of the system of negative images into the mass consciousness of the inhabitants of the post-Soviet space makes it difficult to preserve the remnants of Soviet political symbols and elements constructed on their basis identity. The author puts forward the hypothesis that in the case of complete desovietization of the public policy space in the states that emerged as a result of the collapse of the USSR, the task of revising the history of the Great Patriotic War will be greatly facilitated, and with the subsequent departure from the life of the last eyewitnesses of the relevant events, achieving this goal will be only a
Alexander P. Abramov
Full Text Available On the basis of the historical and sociological material presented materials about the Soviet state measures during the Great Patriotic War for the implementation of social policy in respect of the military air force of the Red Army, expressed in monetary incentives, rewards and social guarantees. The author notes that the implementation of social management practices at each stage of warfare timely adjustments depending on acquired combat experience and the strategic objectives of war. Existing wartime monetary awards system and social guarantees in respect of the personnel of the Red Army Air Force was not a major, but significant moral incentive for both pilots, as for representatives of other arms and services.
Fogwill, Christopher; Turney, Chris; Baker, Andy; Ellis, Bethany; Cooper, Alan; Etheridge, David; Rubino, Mauro; Thornton, David; Fernando, Francisco; Bird, Michale; Munksgaard, Niels
We report preliminary analysis of biomarkers (including dissolved organic matter (DOM) and DNA) from the Patriot Hills blue ice area (BIA), from the Ellsworth Mountains in the Weddell Sea Embayment. Preliminary isotopic and multiple gas analysis (CO2, CH4, N2O and CO) demonstrate that the Holocene comprises more than 50% of the 800m long BIA record, and in combination isotopic and biomarker analysis reveals a remarkable record of centennial variability through the Holocene in this sector of the Weddell Sea. Analysis using a Horiba Aqualog - which measures the fluorescence of DOM by producing a map of the fluorescence through an excitation-emission matrix (EEM) - identifies the presence of two marine protein-like components in both modern snow pit samples and within the Holocene part of Patriot Hills BIA transect. Intriguingly, the modern seasonal trends in DOM, recorded in contemporary snow pits, have relatively low signals compared to those recorded in the mid-Holocene record, suggesting a reduction in DOM signal in contemporary times. Given that the δD excess data suggests the source of precipitation has remained constant through the Holocene, the biomarker signal must relate to multi-year marine productivity signals from the Weddell Sea. The marked variability in DOM between the mid-Holocene and contemporary times can only relate to periods of sustained, enhanced biological productivity in the Weddell Sea associated with shifts in Southern Annular Mode, sea ice variability, changes in ventilation or polynya activity. Here we discuss the possible drivers of these changes and describe how this approach at this BIA could benefit conventional ice core records regionally.
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Electric anesthesia is the anesthesia, usually general anesthesia, produced by the application of an electrical current. This fascinating issue of the anesthesia history was made possible thanks to the pioneering experiments on electrotherapy and electrophysiology performed by two researchers: the neurologist Guillaume Duchenne (1806-1875) and the biologist Stéphane Leduc (1853-1939). The aim of this study is the review of the dispute between two Italian scientists on the effectiveness of electric anesthesia in the second half of the 19th century. One of the two contenders was Rodolfo Rodolfi (1827-1896), an Italian surgeon and patriot who took part in the First Italian War of Independence of 1848, whereas the other protagonist of the dispute was the positivist Plinio Schivardi (1833-1908), a pupil of Duchenne who brought to Italy his knowledge of electrotherapy, collecting these experiences in the Theoretical Practical Manual of Electrotherapy, the first book on the subject written in Italian. Copyright © 2015 Elsevier B.V. All rights reserved.
Romanko Oleg Valentinovich
Full Text Available The article deals with the features of the process of organization and use of the Belarusian collaborationist formations, which were created by the Nazi military and political leadership at the final stages of the Great Patriotic War. It is noted that this aspect of the problem did not practically find the reflection in the historiography. Based on a wide complex of archival sources, the system of organization, training and combat use of such formation, as Belarusian regional defense, is analyzed. The reasons and the aims which were pursued by the German occupants and the Belarusian nationalists at creation of this military formation are established. The author investigates the key events of history of the Belarusian regional defense, its mobilization course, the quality of staff, and the training level of soldiers and officers. The quantitative characteristics of mobilization on a chronological and territorial basis are given. The main difficulties which led to the actual failure of mobilization in the Belarusian regional defense are shown. As a result, the conducted research substantiated conclusion that, despite all efforts of occupants and members of the Belarusian national movement, the process of the organization and use of the Belarusian collaborationist formations in this stage, from the military point of view, completely failed. The political effect was minimal but more essential, however it did not affect the further course of events.
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Андрей Николаевич Балыш
Full Text Available The role of Ammunition Industry in connection with action variation at the first part of 20th century is analyzed in the present paper. It is studied how the New Economic Policy (NEP influenced onto the development of ammunition industry and respective branches of heavy industry. For the first time several manufacturing peculiarities of ammunition main elements (by example of ammunition bodies in the eve of the Great Patriotic War are analyzed on the base of archival documents and the role of these peculiarities in fighting efficiency of the Soviet forces during the Second World War is studied.
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Malysheva Elena Mikhaylovna
Full Text Available The article gives an overview of information confrontation between the USSR and the Third Reich in 1941-1945 in the struggle for the mass consciousness of the civilian population and combatants, shows opposite axiological priorities and forms of propaganda and counter-propaganda of the opposing sides. Of particular interest is the analysis of the struggle for social consciousness, with emphasis on Soviet nationalities policy and the ethnic component of the German occupation regime in the Caucasus. On the one hand, the study and implementation of the thesis about the intellectual, psychosocial and physiological superiority of one people over the other as a natural, more like moral norm was largely propaganda separation of people in order to facilitate the management and maximize the impact of the labor and other forms of cooperation. On the other hand, certain conflict zones, updated by the Nazis in the period between the nations, proved to be viable due to the historical, religious or socio-cultural tension. Nevertheless, it supported the idea that the social consciousness of the peoples of the USSR was based on the belief in a just character of the war, and the victory was the main source of patriotism and interethnic community of Defenders of the Fatherland, which became the basis of resistance and the subsequent defeat of concerted action advocacy program of Nazi Germany. Soviet propaganda skillfully maintained the spirit of unity and protest accumulated effect for the benefit of the people striving for victory over the invaders of his native land. At the same time without contradiction between the spirit and the word of propaganda; the actions of the government and the people. Today, when it is necessary to overcome the historical “amnesia, revisionists try to revive and resuscitate the memory of turning historical events, to achieve their objective assessment of the integrity and historical continuity outlook of the people and adequate
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Dallimer, Martin; Jacobsen, Jette Bredahl; Lundhede, Thomas
The natural environment is central to human well-being through its role in ecosystem service (ES) provision. Managing ES often requires coordination across international borders. Although this may deliver greater conservation gains than countries acting alone, we do not know whether the public su...
Full Text Available This article studies women’s participation in the work of philanthropic patriotism conducted by the Primrose League, a Conservative organisation which remained in activity throughout the First World War. The case of the Primrose League, whose female membership carried out the sort of philanthropic work that conformed to the traditional view of the sexual division of labour, is used to qualify the historiographical interpretation according to which during the war women’s social status went through a dramatic evolution. Discussion then turns to the ambiguous relation of the League’s hierarchy towards the issue of women’s citizenship, which highlights the fact that this organisation embodied a desire to resist the gender disturbances occasioned by the war.
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Leviton, Harvey S.
This article attempts to assemble pertinent information about the drug problem, particularily marihuana. It also focuses on the need for an educational program for drug control with the public schools as the main arena. (Author/HMV)
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Goločorbin-Kon, Svetlana; Vojinović, Aleksandra; Lalić-Popović, Mladena; Pavlović, Nebojša; Mikov, Momir
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Apr 12, 2009 ... ABStrAct. Since drugs became both a public and social issue in Nigeria, fear about both the real and .... drugs as being morally reprehensible, and ..... tice system (see for instance, Shaw, 1995; ..... A cut throat business:.
Autorist lk. 2. Sisu: "Mesta vstretsh zametenõ peskom..." ; "Jesli nam dovedjotsja uvidet..." ; "Mõ dõshim jedinõm dõhhanjem..." ; "Neuzhto tõ do sih por ne verish..." ; "Voprossitelnõi znak..." ; "Krov morje..." ; "Slushaite morje..." ; "Telo v zholtom okne..." ; "Ja znaju..." ; "Vsjo tshto dvigalos..." ; "I vot zakrõvajesh svet totshno knigu..."
Roč. 65, č. 2 (2017), s. 221-235 ISSN 0015-1831 Grant - others:AV ČR(CZ) StrategieAV21/13 Program:StrategieAV Institutional support: RVO:67985955 Keywords : David Hume * necessity * liberty * responsibility * punishment Subject RIV: AA - Philosophy ; Religion OBOR OECD: Philosophy, History and Philosophy of science and technology
Chronic obstructive pulmonary disease - control drugs; Bronchodilators - COPD - control drugs; Beta agonist inhaler - COPD - control drugs; Anticholinergic inhaler - COPD - control drugs; Long-acting inhaler - COPD - control drugs; ...
Golocorbin Kon, Svetlana; Vojinović, Aleksandra; Lalić-Popović, Mladena; Pavlović, Nebojsa; Mikov, Momir
Drugs used for treatment of rare diseases are known worldwide under the term of orphan drugs because pharmaceutical companies have not been interested in "adopting" them, that is in investing in research, developing and producing these drugs. This kind of policy has been justified by the fact that these drugs are targeted for small markets, that only a small number of patients is available for clinical trials, and that large investments are required for the development of drugs meant to treat diseases whose pathogenesis has not yet been clarified in majority of cases. The aim of this paper is to present previous and present status of orphan drugs in Serbia and other countries. THE BEGINNING OF ORPHAN DRUGS DEVELOPMENT: This problem was first recognized by Congress of the United States of America in January 1983, and when the "Orphan Drug Act" was passed, it was a turning point in the development of orphan drugs. This law provides pharmaceutical companies with a series of reliefs, both financial ones that allow them to regain funds invested into the research and development and regulatory ones. Seven years of marketing exclusivity, as a type of patent monopoly, is the most important relief that enables companies to make large profits. There are no sufficient funds and institutions to give financial support to the patients. It is therefore necessary to make health professionals much more aware of rare diseases in order to avoid time loss in making the right diagnosis and thus to gain more time to treat rare diseases. The importance of discovery, development and production of orphan drugs lies in the number of patients whose life quality can be improved significantly by administration of these drugs as well as in the number of potential survivals resulting from the treatment with these drugs.
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Sadée, Wolfgang; El Sayed, Yousry Mahmoud
The limited scope of therapeutic drug-level monitoring in cancer chemotherapy results from the often complex biochemical mechanisms that contribute to antineoplastic activity and obscure the relationships among drug serum levels and therapeutic benefits. Moreover, new agents for cancer chemotherapy are being introduced at a more rapid rate than for the treatment of other diseases, although the successful application of therapeutic drug-level monitoring may require several years of intensive study of the significance of serum drug levels. However, drug level monitoring can be of considerable value during phase I clinical trials of new antineoplastic agents in order to assess drug metabolism, bioavailability, and intersubject variability; these are important parameters in the interpretation of clinical studies, but have no immediate benefit to the patient. High performance liquid chromatography (HPLC) probably represents the most versatile and easily adaptable analytical technique for drug metabolite screening (1). HPLC may therefore now be the method of choice during phase I clinical trials of antineoplastic drugs. For example, within a single week we developed an HPLC assay—using a C18 reverse-phase column, UV detection, and direct serum injection after protein precipitation—for the new radiosensitizer, misonidazole (2).
... Survey Results Synthetic Cannabinoids (K2/Spice) Unpredictable Danger Drug and Alcohol Use in College-Age Adults in 2016 Monitoring the Future 2016 Survey Results Drug and Alcohol Use in College-Age Adults in 2015 View All NIDA Home ...
Zhou, Bin; Wang, Rong; Wu, Ping; Kong, De-Xin
Given the high risk and lengthy procedure of traditional drug development, drug repurposing is gaining more and more attention. Although many types of drug information have been used to repurpose drugs, drug-drug interaction data, which imply possible physiological effects or targets of drugs, remain unexploited. In this work, similarity of drug interaction was employed to infer similarity of the physiological effects or targets for the drugs. We collected 10,835 drug-drug interactions concerning 1074 drugs, and for 700 of them, drug similarity scores based on drug interaction profiles were computed and rendered using a drug association network with 589 nodes (drugs) and 2375 edges (drug similarity scores). The 589 drugs were clustered into 98 groups with Markov Clustering Algorithm, most of which were significantly correlated with certain drug functions. This indicates that the network can be used to infer the physiological effects of drugs. Furthermore, we evaluated the ability of this drug association network to predict drug targets. The results show that the method is effective for 317 of 561 drugs that have known targets. Comparison of this method with the structure-based approach shows that they are complementary. In summary, this study demonstrates the feasibility of drug repurposing based on drug-drug interaction data. © 2014 John Wiley & Sons A/S.
Guerreiro, Diogo Frasquilho; Carmo, Ana Lisa; da Silva, Joaquim Alves; Navarro, Rita; Góis, Carlos
Club drugs are the following substances: Methylenedioxymethamphetamine (MDMA); Methamphetamine; Lysergic Acid Diethylamide (LSD); Ketamine; Gamma-hydroxybutyrate (GHB) and Flunitrazepam. These substances are mainly used by adolescents and young adults, mostly in recreational settings like dance clubs and rave parties. These drugs have diverse psychotropic effects, are associated with several degrees of toxicity, dependence and long term adverse effects. Some have been used for several decades, while others are relatively recent substances of abuse. They have distinct pharmacodynamic and pharmacokinetic properties, are not easy to detect and, many times, the use of club drugs is under diagnosed. Although the use of these drugs is increasingly common, few health professionals feel comfortable with the diagnosis and treatment. The authors performed a systematic literature review, with the goal of synthesising the existing knowledge about club drugs, namely epidemiology, mechanism of action, detection, adverse reactions and treatment. The purpose of this article is creating in Portuguese language a knowledge data base on club drugs, that health professionals of various specialties can use as a reference when dealing with individual with this kind of drug abuse.
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Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 3. Drug Metabolism: A Fascinating Link Between Chemistry and Biology. Nikhil Taxak Prasad V Bharatam. General Article Volume 19 Issue 3 March 2014 pp 259-282 ...
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behind metabolic reactions, importance, and consequences with several ... required for drug action. ... lism, which is catalyzed by enzymes present in the above-men- ... catalyze the transfer of one atom of oxygen to a substrate produc-.
Full Text Available ... Ecstasy, Molly) Facts Meth (Crank, Ice) Facts Pain Medicine (Oxy, Vike) Facts Spice (K2) Facts Tobacco and ... Bath Salts Cocaine Heroin Marijuana MDMA Meth Pain Medicines Spice (K2) Tobacco/Nicotine Other Drugs You can ...
Full Text Available ... 800-662-HELP (4357) at any time to find drug treatment centers near you. I want my ... is making positive changes in her life. She finds support from family and friends who don't ...
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Full Text Available ... Together The Link Between Drug Use and HIV/AIDS Treatment & Recovery Why Does a Person Need Treatment? ... of Health (NIH) , the principal biomedical and behavioral research agency of the United States Government. NIH is ...
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Full Text Available ... prescription drugs. The addiction slowly took over his life. I need different people around me. To stop ... marijuana, "Cristina" is making positive changes in her life. She finds support from family and friends who ...
... Drug-resistance testing is also recommended for all pregnant women with HIV before starting HIV medicines and also in some pregnant women already taking HIV medicines. Pregnant women will work with their health ...
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... as hearing colors Impulsive behavior Rapid shifts in emotions Permanent mental changes in perception Rapid heart rate ... Drug use can negatively affect academic performance and motivation to excel in school. Legal issues. Legal problems ...
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Indrati, Dina; Prasetyo, Herry
ABSTRACT : Labelling drugs are important issue nowadays in a modern society. Although it is generally believed that legal drugs are good drugs and illegal drugs are bad drugs, it is evident that some people do not aware about the side effects of drugs used. Therefore, a key contention of this philosophical essay is that explores harms minimisation policy, discuss whether legal drugs are good drugs and illegal drugs are bad drugs and explores relation of drugs misuse in a psychiatric nursing s...
... Cosmetics Tobacco Products Home Drug Databases Drugs@FDA Drugs@FDA: FDA Approved Drug Products Share Tweet Linkedin Pin it More sharing ... Download Drugs@FDA Express for free Search by Drug Name, Active Ingredient, or Application Number Enter at ...
Lam, Stephanie Phuong; Roosta, Natalie; Nielsen, Mikkel Fuhr; Meyer, Maria Holmgaard; Friis, Katrine Birk
In recent years, students around the world, started to use preparations as Ritalin and Modafinil,also known as study drugs, to improve their cognitive abilities1. It is a common use among thestudents in United States of America, but it is a new tendency in Denmark. Our main focus is tolocate whether study drugs needs to be legalized in Denmark or not. To investigate this ourstarting point is to understand central ethical arguments in the debate. We have chosen twoarguments from Nick Bostrom a...
Full Text Available ... Phone Numbers and Websites Search Share Listen English Español Information about this page Click on the button ... sobre el abuso de drogas, y adicción. English Español About the National Institute on Drug Abuse (NIDA) | ...
tests (LFTs) to monitor hepatotoxicity (liver [hepatic] damage) is uncommon in many resource-poor ... cholesterol ester storage disease. ... The problem with many patients is that they are taking several drugs often ... Urine, saliva and other body fluids may be coloured orange-red: this can be very alarming to patients.
Gorter, J.A.; Potschka, H.; Noebels, J.L.; Avoli, M.; Rogawski, M.A.; Olsen, R.W.; Delgado-Escueta, A.V.
Drug resistance remains to be one of the major challenges in epilepsy therapy. Identification of factors that contribute to therapeutic failure is crucial for future development of novel therapeutic strategies for difficult-to-treat epilepsies. Several clinical studies have shown that high seizure
preventing disease in human beings or in animals. In the process ... of requirement. In the process, they may cause toxic side effects. .... the liver to release the physiologically active drug. Similarly ... patients addicted to alcohol. However, it is a ...
Full Text Available ... Prevention Phone Numbers and Websites Search Share Listen English Español Information about this page Click on the ... información sobre el abuso de drogas, y adicción. English Español About the National Institute on Drug Abuse ( ...
... use of these drugs is a form of drug abuse. Medicines that are for treating a health problem ... about local resources. Alternative Names Overdose from drugs; Drug abuse first aid References Myck MB. Hallucinogens and drugs ...
... This series is produced by Consumers Union and Consumer Reports Best Buy Drugs , a public information project sup- ported by grants from the Engelberg Foundation and the National Library of Medicine of ... Consumer and Prescriber Education Grant Program which is funded ...
Full Text Available ABSTRACT : Labelling drugs are important issue nowadays in a modern society. Although it is generally believed that legal drugs are good drugs and illegal drugs are bad drugs, it is evident that some people do not aware about the side effects of drugs used. Therefore, a key contention of this philosophical essay is that explores harms minimisation policy, discuss whether legal drugs are good drugs and illegal drugs are bad drugs and explores relation of drugs misuse in a psychiatric nursing setting and dual diagnosis.Key words: Legal, good drugs, illegal, bad drugs.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for neuroblastoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the FDA for use in leukemia. The drug names link to NCI's Cancer Drug Information summaries. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.
U.S. Department of Health & Human Services — The Drug Listing Act of 1972 requires registered drug establishments to provide the Food and Drug Administration (FDA) with a current list of all drugs manufactured,...
... People Abuse » Other Drugs of Abuse Other Drugs of Abuse Listen There are many other drugs of abuse, ... and Rehab Resources About the National Institute on Drug Abuse (NIDA) | About This Website Tools and Resources | Contact ...
Drug screen - urine ... detect the presence of illegal and some prescription drugs in your urine. Their presence may indicate that you recently used these drugs. Some drugs may remain in your system for ...
... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix xi Part I Drugs and Their Actions . . . . . . . . . . . . . . . . . . . . . . 1 Psychoactive drugs: introduction and overview . . . . . . . . 2 The brain...
... drug abuse. And it's illegal, just like taking street drugs. Why Do People Abuse Prescription Drugs? Some people abuse prescription drugs ... common risk of prescription drug abuse is addiction . People who abuse ... as if they were taking street drugs. That's one reason most doctors won't ...
Simon, T.R.; Seastrunk, J.W.; Malone, G.; Knesevich, M.A.; Hickey, D.C.
This paper reports that this study used SPECT to examine patients who have abused drugs to determine whether SPECT could identify abnormalities and whether these findings have clinical importance. Fifteen patients with a history of substance abuse (eight with cocaine, six with amphetamine, and one with organic solvent) underwent SPECT performed with a triple-headed camera and Tc-99m HMPAO both early for blood flow and later for functional information. These images were then processed into a 3D videotaped display used in group therapy. All 15 patients had multiple areas of decreased tracer uptake peppered throughout the cortex but mainly affecting the parietal lobes, expect for the organic solvent abuser who had a large parietal defect. The videotapes were subjectively described by a therapist as an exceptional tool that countered patient denial of physical damage from substance abuse. Statistical studies of recidivism between groups is under way
Feldman, Marc; Boyer, Bret; Kumar, V. K.; Prout, Maurice
This study examined the relationship between drug preference, drug use, drug availability, and personality among individuals (n = 100) in treatment for substance abuse in an effort to replicate the results of an earlier study (Feldman, Kumar, Angelini, Pekala, & Porter, 2007) designed to test prediction derived from Eysenck's (1957, 1967)…
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for rhabdomyosarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries. There may be drugs used in rhabdomyosarcoma that are not listed here.
... approved drugs Drugs@FDA Information on FDA-approved brand name and generic drugs including labeling and regulatory history Drugs with Approved Risk Evaluation and Mitigation Strategies (REMS) REMS is a risk management plan required by FDA for certain prescription drugs, ...
Kelssering, G.; Aguiar, L.F.; Ribeiro, R.M.; Souza, A.Z. de
Different kinds of drugs who can be transferred through the mother's milk to the lactant and its effects are showed in this work. A list of them as below: cardiotonics, diuretics, anti-hypertensives, beta-blockings, anti-arrythmics, drugs with gastrintestinal tract action, hormones, antibiotics and chemotherapeutics, citostatic drugs, central nervous system action drugs and anticoagulants drugs. (L.M.J.) [pt
Center for Human Reliability Studies
The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.
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Teenagers and drugs; Symptoms of drug use in teenagers; Drug abuse - teenagers; Substance abuse - teenagers ... for a specialist who has experience working with teenagers. Do not hesitate, get help right away. The ...
U.S. Department of Health & Human Services — The Interaction API is a web service for accessing drug-drug interactions. No license is needed to use the Interaction API. Currently, the API uses DrugBank for its...
Full Text Available This paper begins with the analysis of the socio-cultural phenomenon known as “public space.” This analysis is followed by the reflection on distinctive features of public space in contemporary China. Subsequently, I focus on the use of public space by Chinese authorities for spreading official political and ideological discourse. For this purpose, I analyse the form and content of messages displayed in places of public utility. I conclude by showing what, how and why these are being displayed and widely promoted by the authorities. I argue that public space in China, on the one hand, is “public” in the sense that it is accessible and used by citizens; on the other, it is “arrested by authorities” and used for their socio-political and ideological purposes. Such an arrangement is a statement of the unvocalised agreement between the authorities and citizens that allows the former to avoid major conflicts with the latter and legitimise political power. In return, the latter enjoy a wide range of socio-cultural freedom and are being provided with psychological comfort resulting from identification with a greater endeavour of restoring the glory of the Chinese nation.
E. A. Sverdlikova
Full Text Available A study of employees’ loyalty to organization is usually associated with the analysis of the organizational culture, its norms, values, rules, which create a peculiar relationships the staff and the organization. In modern Russia there is an interesting symbiosis of the different epochs cultures, determining the personnel loyalty to organizations. The article represents the results of the researches received in the last decade by well-known Western and Russian sociological centers, as well as by some separate Russian sociologists. A significant feature of these studies is that they were conducted solely with the use of quantitative methods and in the format of Western corporate values and Western evaluation tools. The author research demonstrates that the corporate culture of Russian organizations, as well as the personnel loyalty, does not meet many inherent in international practice, evaluation criteria. Russian business culture is usually regarded as being in the process of becoming, to some extent, “underdeveloped” in comparison with the culture that exists in countries with strong capitalist traditions. This is not true. Over 25 years in Russia of market economy development have formed a certain system of values, incorporating values of pre-revolutionary business, ideological orientations of the Soviet era and the values that have been formed in recent years. Low degree of personnel’s loyalty towards the organizations, in this respect, is not a symptom of the cultural underdevelopment, it is a specific cultural trait of the domestic business, which has a quite rational basis and is not a subject to exclusively negative interpretation. This conclusion is based on the results of qualitative and quantitative research, conducted using methods of biographical analysis and content analysis of contemporary business periodicals. These qualitative and quantitative research methods in the analysis of the Russian corporate values determine a deeper look at the staff of the modern Russian organizations. Deeper analysis shows, that people seek to embody in their lives, at work and at home, high principles and ideals. The study of documents and analysis of periodicals testifies the fact that modern “captains of business” and the personnel, overall, are repro- 118 duced skills and values inherent in the previous generations. The most significant values of this kind are the values of the Russian diligence and the predominance of the moral forms of motivation over the material. These data are meaningful for characteristics of modern Russian business culture in general, as well as characteristics of the personnel loyalty to the organization.
The author discusses how universities might serve the public interest by stirring up not fewer but more and deeper debates on the failures of intelligence that afflicted American institutions before 11 September 2001--and he does not refer simply to the feebleness of the FBI and other investigation bureaucracies. He refers to the parochialism, the…
Building a personal identity is a lifelong, thoughtful process that takes into account not only one's race and ethnicity, but also life experiences, relationships, and communities. The process of exploring and evolving one's identity deserves a place in the classroom. Educators can play a key role in supporting their students' in this process by…
This article examines the role of United States holocaust museums in directing (American) knowledge and memory of World War II, and demonstrates how signifiers of race, colour and Jewishness are played out and theatricalised. Erected in two principal U.S. cities of Los Angeles and Washington, D.C., the Holocaust Museum and Museum of Tolerance uphold very different mandates: the first dedicated to revealing European civilian tragedies during WWII; the latter dealing with Jewish persecution and...
Hansen, Peer Henrik
Umiddelbart efter anden verdenskrig indledte den amerikanske efterretningstjeneste Office of Strategic Service (OSS) samarbejde med en række danske politikere og modstands- og efterretningsfolk. En af dem var Svend Truelsen, en af modstandskampens store helte...
.... It has several provisions, however, that might apply in a library context. The most frequently mentioned of these is Section 215 that amends the business record sections of the Foreign Surveillance Intelligence Act (FISA...
Full Text Available This article examines the role of United States holocaust museums in directing (American knowledge and memory of World War II, and demonstrates how signifiers of race, colour and Jewishness are played out and theatricalised. Erected in two principal U.S. cities of Los Angeles and Washington, D.C., the Holocaust Museum and Museum of Tolerance uphold very different mandates: the first dedicated to revealing European civilian tragedies during WWII; the latter dealing with Jewish persecution and the L.A. Riots of 1991, with references to other cultural catastrophes. While these projects are different, they are not opposed; both museums locate the American perspective of events and their meanings at the forefront. American holocaust museums seem to challenge spaces between memory and its direction, vision and revision. Within the gruesome context of holocaust portrayal, interrogate the valences of memory’s play and expose American holocaust museums as theatres of pornographic memory. The seduction of feeling does not invite change so much as purgation, what Aristotle identified as catharsis — an emotional and physical release, unfortunately replicating the seductive techniques used by Goebbels for the glorification of Hitler. Through manipulation of viewers as automatic audiences, these museums function as centres for pathos I question the policy and polity of presenting genocide as an entertainment leading to catharsis, recognizing that the final act of purgation is all too easily negation.
V. M. Danilova
Full Text Available The article presents the facts about life and research activity of Ivan Ya. Gorbachevsky (1854-1942, the prominent scientist, Ukrainian by origin, doctor of medical sciences, professor, dean of the medical faculty and the rector of Charles University in Prague, member of the health board of the Czech Kingdom, a member of the Supreme Council of Health of Austria-Hungary in Vienna, a lifelong member of the House of Lords of the Austrian Parliament, first health minister of Austria-Hungary, rector of the Ukrainian Free University in Prague, professor of chemistry at the Padebradsk Economic Academy and the Ukrainian Pedagogical Dragomanov University, AUAS member in 1925, member of the Shevchenko Scientific Society. His research works were devoted to digestion of proteins, public and food hygiene. He was the first who synthesized uric acid (1882 and discovered xanthine oxidase (1889.
Sørensen, Casper Falbe; Harild, Jonas Arboe
This master thesis examines the means with which American war propaganda was integrated in popular American theatrical cartoons during World War II. Through a theoretical understanding of propaganda inspired by Garth S. Jowett and Victoria O’Donnell, the fundamental aspects of the creation of propaganda aimed at the public, are examined. Furthermore we use Roland Barthes’ theory of myths to describe how both the cartoon medium and well-known animated figures were used for propaganda purposes ...
Book Review: Odintsov, M. I. Confessional Policy in the Soviet Union during the Great Patriotic War in 1941-1945 [Text] / M. I. Odintsov, A. S. Kochetova. – M. : Scientific & Political Book : Political Encyclopedia, 2014. – 317 p. – (History of Stalinism
Vadim N. Yakunin
Full Text Available The book contains the information about the status and activities of churches and religious groups in the Soviet Union before and during the Great Patriotic War in 1941–1945. The causes which led to the change in the policy of the Soviet government against the religious organizations are identified, the analysis of the activities of the Soviet state on creating a new system of state-church relations, the main stages of its development are represented. The activity of the newly created authorities on “Religious Affairs” – the Council for Russian Orthodox Church and the Religious Affairs Council is revealed. The authors show a response to the change in the statechurch relations in the center and different strata of Soviet society and also the ratio of official policy and propaganda with a specific embodiment of the state church policy. M.I. Odintsov and A.S. Kochetova analyze the situation and activity of religious organizations in the occupied territories of the USSR. The plans and main directions of the Nazi policy towards religion and religious organizations in the occupied territories of the USSR, directives of the political and military leadership of Nazi Germany are studied. The authors compare the religious policies of Nazi Germany and the Soviet Union and show their similarities and differences, emphasizing that the last ones were most clearly expressed from the beginning of the Great Patriotic War. The book features a wide source base. The documentation of 6 major Russian archives was used for solving the research problem.
The family in patriotic education of young learners living in the United Kingdom as an example of foreign country (in 1945–1989 [Rola rodziny w wychowaniu ojczystym dziecka na obczyźnie na przykładzie Wielkiej Brytanii (w latach 1945–1989
Full Text Available The article deals with the role of the family in thepatriotic education of young learners living in a foreign country. The essential role of the family was to develop the national identity, to make the children feel proud of their country and to prevent them having a sense of social inferiority. Patriotic education was to instil love to an unknown country – Poland and a national identity in young learners, but mainly to give new perspectives on spiritual life. Some forms and methods in patriotic education were described in this article, e.g. teaching children about national traditions, monuments and church or state celebrations, reminding about the necessity of cultivating holiday customs and traditions and about the central role of the mother in the family. Apart from that Polish folklore played a vital role in educating children abroad, e.g. folk music, dance, songs and handicrafts or national costumes. The children had to learn to love their country as well as to live in a Polish family with all it customs, traditions and language to feel as Polish citizens still living in a foreign country. The article puts stress on the significance of cooperation between parents and Polish schools in educating children in Britain. The main aim of the close cooperation was to develop children and their personalities. Some forms and ways of interactions analysed in this paper were based on such articles in: „Wiadomości Nauczycielskie”, „Dziennik Polski” or „Dziennik Żołnierza”
Küsitletakse soengukunsti maailmameistrivõistlustel Hair World 2002 Las-Vegases osalenud juuksur Tamara Korjaginat, jumestuskunstnik Katrin Sanglat ja moekunstnik Gerly Tinni võistluse kohta. Saavutasid võiskondlikus arvestuses kolmanda koha
... Used Drugs in the Past Drug Use Prevention Phone Numbers and Websites Search ... who aren't yet born. Drug use can hurt the body and the brain, sometimes forever. Drug use can also lead to addiction, a long-lasting brain disease in which people ...
Drug abuse is a serious public health problem. It affects almost every community and family in some way. Drug abuse in children and teenagers may pose a ... of young people may be more susceptible to drug abuse and addiction than adult brains. Abused drugs ...
İLHAN, Mustafa Necmi
The NationalStrategy Document on Drugs and Emergency Action Plan started with thecontributions of all the relevant institutions within the year of 2014 wasprepared and after that in accordance with the Prime Ministry Notice entitledFight Against Drugs published within this scope, the committees for FightAgainst Drugs were established (under the presidency of Deputy Prime Ministerand with the help of Ministry of Health, Ministry of Justice, Ministry of Laborand Social Security, Ministry of Fam...
Hansen, J M; Christensen, L K
The effect of the oral sulphonylurea hypoglycaemic drugs may be influenced by a large number of other drugs. Some of these combinations (e.g. phenylbutazone, sulphaphenazole) may result in cases of severe hypoglycaemic collapse. Tolbutamide and chlorpropamide should never be given to a patient without a prior careful check of which medicaments are already being given. Similarly, no drug should be given to a diabetic treated with tolbutamide and chlorpropamide without consideration of the possibility of interaction phenomena.
Common illegal drugs include cannabis, cocaine, opiates, and synthetic drugs. International trade in these drugs represents a lucrative and what...into effect, decriminalizing “personal use” amounts of marijuana , heroin, cocaine, methamphetamine, and other internationally sanctioned drugs.15 While...President Calls for Legalizing Marijuana ,”CNN.com, May 13, 2009. 15 “Mexico Legalizes Drug Possession,” Associated Press, August 21, 2009. 16 In support
U.S. Department of Health & Human Services — Active drugs that have been reported by participating drug manufacturers under the Medicaid Drug Rebate Program. All drugs are identified by National Drug Code...
Tonge, Peter J
The development of therapies for the treatment of neurological cancer faces a number of major challenges including the synthesis of small molecule agents that can penetrate the blood-brain barrier (BBB). Given the likelihood that in many cases drug exposure will be lower in the CNS than in systemic circulation, it follows that strategies should be employed that can sustain target engagement at low drug concentration. Time dependent target occupancy is a function of both the drug and target concentration as well as the thermodynamic and kinetic parameters that describe the binding reaction coordinate, and sustained target occupancy can be achieved through structural modifications that increase target (re)binding and/or that decrease the rate of drug dissociation. The discovery and deployment of compounds with optimized kinetic effects requires information on the structure-kinetic relationships that modulate the kinetics of binding, and the molecular factors that control the translation of drug-target kinetics to time-dependent drug activity in the disease state. This Review first introduces the potential benefits of drug-target kinetics, such as the ability to delineate both thermodynamic and kinetic selectivity, and then describes factors, such as target vulnerability, that impact the utility of kinetic selectivity. The Review concludes with a description of a mechanistic PK/PD model that integrates drug-target kinetics into predictions of drug activity.
Simonsen, K W; Kaa, E
The aim of this investigation was to examine illegal tablets and capsules seized in Jutland, the western part of Denmark, during the period 1995-1999. The drugs are described according to technical appearance (colour, logo, score, diameter) and content of synthetic drugs. All illegal tablets and capsules received during the period 1995-1999 (109 cases containing 192 different samples) were examined. MDMA was the most common drug and was seen during the entire period. Amphetamine was the second most common drug and has been frequently detected during the the last two years. Drugs like MDE, MBDB, BDB, and 2-CB were rarely seen and they disappeared quickly from the illegal market. MDA appeared on the market at the end of 1999. Only 53% of the tablets contained MDMA as the sole drug. Eighty-one percent of the tablets/capsules contained only one synthetic drug, whereas 13% contained a mixture of two or more synthetic drugs. Six per cent of the samples did not contain a euphoric drug/designer drug. The content of MDMA, MDE, and amphetamine in the tablets varied greatly. MDMA is apparently the drug preferred by the users, but still only half of the tablets contained MDMA as the only drug. The rest of the tablets contained either another synthetic drug or a mixture of drugs. In conclusion, the increasing supply of various drugs with different and unpredictable effects and of miscellaneous quality brings about the risk of serious and complicated intoxications.
U.S. Department of Health & Human Services — Product Data for Drugs in the Medicaid Drug Rebate Program. The rebate drug product data file contains the active drugs that have been reported by participating drug...
Full Text Available ... Cigs Other Drugs Related Topics Addiction Science Adolescent Brain Comorbidity College-Age & Young Adults Criminal Justice Drugged Driving Drug Testing Drugs and the Brain Genetics Global Health Health Consequences of Drug Misuse ...
Schmidt, Lars E; Dalhoff, Kim
Interactions between food and drugs may inadvertently reduce or increase the drug effect. The majority of clinically relevant food-drug interactions are caused by food-induced changes in the bioavailability of the drug. Since the bioavailability and clinical effect of most drugs are correlated......, the bioavailability is an important pharmacokinetic effect parameter. However, in order to evaluate the clinical relevance of a food-drug interaction, the impact of food intake on the clinical effect of the drug has to be quantified as well. As a result of quality review in healthcare systems, healthcare providers...... are increasingly required to develop methods for identifying and preventing adverse food-drug interactions. In this review of original literature, we have tried to provide both pharmacokinetic and clinical effect parameters of clinically relevant food-drug interactions. The most important interactions are those...
The Dutch parliament enacted the revised Opium Act in 1976. This penal law is part of the Dutch drug policy framework that includes tolerance for nonconforming lifestyles, risk reduction in regard to the harmful health and social consequences of drug taking, and penal measures directed against
Arshad Yar Khan
Full Text Available The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction, food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction or another disease the person has (drug-disease interaction. A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects. Clinically significant drug interactions, which pose potential harm to the patient, may result from changes in pharmaceutical, pharmacokinetic, or pharmacodynamic properties. Some may be taken advantage of, to the benefit of patients, but more commonly drug interactions result in adverse drug events. Therefore it is advisable for patients to follow the physician and doctors instructions to obtain maximum benefits with least fooddrug interactions. The literature survey was conducted by extracting data from different review and original articles on general or specific drug interactions with food. This review gives information about various interactions between different foods and drugs and will help physicians and pharmacists prescribe drugs cautiously with only suitable food supplement to get maximum benefit for the patient.
Max Joseph Herman
Full Text Available Although essentially not all therapies need drug intervention, drugs is still an important components in health sector, either in preventive, curative, rehabilitative or promotion efforts. Hence the access to drugs is a main problem, either in international or national scale even to the smallest unit. The problem on access to drugs is very complicated and cannot be separated especially from pharmacy management problems; moreover in general from the overall lack of policy development and effective of health policy, and also the implementation process. With the policy development and effective health policy, rational drug uses, sufficient health service budget so a country can overcome the health problems. Besides infrastructures, regulations, distribution and cultural influences; the main obstacles for drug access is drugs affordability if the price of drugs is an important part and determined by many factors, especially the drug status whether is still patent orgenerics that significantly decrease cost of health cares and enhance the drugs affordability. The determination of essential drug prices in developing countries should based on equity principal so that poor people pay cheaper and could afford the essential drugs. WHO predicts two third of world population can not afford the essential drugs in which in developing countries, some are because of in efficient budget allocation in consequence of drug distribution management, including incorrect selection and allocation and also irrational uses. In part these could be overcome by enhancing performances on the allocation pharmacy needs, including the management of information system, inventory management, stock management and the distribution. Key words: access, drugs, essential drugs, generic drugs
Pedersen-Bjergaard, U; Andersen, M; Hansen, P B
induced by non-cytotoxic drugs is characterised by heterogeneous clinical picture and recovery is generally rapid. Although corticosteroids seem inefficient, we still recommend that severe symptomatic cases of drug-induced thrombocytopenia are treated as idiopathic thrombocytopenic purpura due...
U.S. Department of Health & Human Services — Information about FDA-approved brand name and generic prescription and over-the-counter human drugs and biological therapeutic products. Drugs@FDA includes most of...
Inflammatory Drug (NSAID)-Induced Seizures in a Patient with HIV Infection ... interaction not supported by existing literature, and it is possible that the background HIV infection may have a role to .... Foods and Drug Administration and Control.
U.S. Department of Health & Human Services — CMS has released several information products that provide spending information for prescription drugs in the Medicare and Medicaid programs. The CMS Drug Spending...
... de informacin confidencial --> DEA NEWS The Drug Enforcement Administration and Discovery Education name grand winner of Operation ... JUN 15 (Washington) The United States Drug Enforcement Administration, DEA Educational Foundation and Discovery Education awarded Porter ...
... with facebook share with twitter share with linkedin Antimicrobial (Drug) Resistance Go to Information for Researchers ► Credit: ... and infectious diseases. Why Is the Study of Antimicrobial (Drug) Resistance a Priority for NIAID? Over time, ...
U.S. Department of Health & Human Services — Companies are required under Section 506C of the Federal Food, Drug, and Cosmetic Act (FD&C Act) (as amended by the Food and Drug Administration Safety and...
U.S. Department of Health & Human Services — This release contains the Prescription Drug Profiles Public Use Files (PUFs) drawn from Medicare prescription drug claims for the year of the date on which the...
... what the doctor prescribed, it is called prescription drug abuse. It could be Taking a medicine that ... purpose, such as getting high Abusing some prescription drugs can lead to addiction. These include opioids, sedatives, ...
... National Drug IQ Challenge 2017 Reto nacional del coeficiente intelectual (CI) sobre las drogas y el alcohol 2016 National Drug IQ Challenge 2016 Reto nacional del coeficiente intelectual (CI) sobre las drogas y el alcohol 2015 ...
... Training Home Conditions Medication/Drug Allergy Medication/Drug Allergy Make an Appointment Find a Doctor Ask a ... risk for adverse reactions to medications. Facts about Allergies The tendency to develop allergies may be inherited. ...
This new edition includes fresh information regarding drugs use and abuse in sport and the updated worldwide anti-doping laws, and changes to the prohibited and therapeutic use exemption lists. The objectives of the book are to review/discuss the latest information on drugs in sport by considering i) actions of drugs and hormones, ii) medication and nutritional supplements in sport, iii) the latest doping control regulations of the WADA, iv) the use of banned therapeutic drugs in sport, v) an...
In this article which is a review of sociological ideas and studies of drug abusers in social situation, drug addiction steps (particularly alcohol, heroin and cocaine consumption) are revised and some explanations are made. Also, the role of some sociological ideas in drug addiction is considered in which Anomie Theory reads: "because of such duality, the individuals who are not satisfied with their role are in hurt." According to this theory, drug users choose seclusion and neglecting usual...
Personalized medicine is still in its infancy concerning drug development in neuropsychopharmacology. Adequate biomarkers with clinical relevance to drug response and/or tolerability and safety largely remain to be identified. Possibly, this kind of personalized medicine will first gain clinical relevance in the dementias. The clinical relevance of the genotyping of drug-metabolizing enzymes as suggested by drug licensing authorities for the pharmacokinetic evaluation of medicinal products needs to be proven in sound clinical trials.
Hesslewood, S.; Leung, E.
Considerable information on documented drug and radiopharmaceutical interactions has been assembled in a tabular form, classified by the type of nuclear medicine study. The aim is to provide a rapid reference for nuclear medicine staff to look for such interactions. The initiation of drug chart monitoring or drug history taking of nuclear medicine patients and the reporting of such events are encouraged. (orig.)
Joseph, Donald E., Ed.
This Drug Enforcement Administration publication delivers clear, scientific information about drugs in a factual, straightforward way, combined with precise photographs shot to scale. The publication is intended to serve as an A to Z guide for drug history, effects, and identification information. Chapters are included on the Controlled Substances…
Department of Justice, Washington, DC.
This fact sheet contains information relating to drug abuse and abusers; drug traffic legislation; law enforcement; and descriptions of commonly used narcotics, stimulants, depressants, and hallucinogens. Also included is a short but explicit listing of audiovisual aids, an annotated bibliography, and drug identification pictures. The booklet…
Janosik, Steven M.; Anderson, David S.
A checklist to help colleges and universities reevaluate their policies and procedures regarding drug use among college students is presented. It is designed to supplement the "Collegiate Alcohol Risk Assessment Guide." In this guide drugs other than alcohol are of concern, although alcohol is viewed by many as the "drug of choice" among college…
The paper juxtaposes the cultural mediation of experience through drugs with that performed with text. As a sample of the currently radically changing relations between professional and lay knowledge in the field of drug interventions, the website of a Copenhagen institution for young drug users ...
Rollins, Joan H.; Holden, Raymond H.
This paper analyzes data from interviews with 167 drug users in the community, including age, sex, birth order, education, family constellation, and circumstances of first drug use. The majority of subjects had tried to stop using drugs, but most had been unsuccessful at the time of the interview. (Author)
Hervada, A R; Feit, E; Sagraves, R
The amount of drug excreted into breast milk is dependent upon the lipid solubility of the medication, the mechanism of transport, the degree of ionization, and change in plasma pH. The higher the lipid solubility, the greater the concentration in human milk. The majority of drugs are transported into mammary blood capillaries by passive diffusion. The rest are transported by reverse pinocytosis. Once the drug has entered the epithelial cells of breast tissue, the drug molecules are excreted into the human milk by active transport, passive diffusion, or apocrine secretion. The amount of free (active) drug available for transport depends on the degree of protein binding the plasma pH. Another factor affecting excretion of drugs is the time when breast feeding occurs. In the 1st few days of life, when colostrum is present, water-soluble drugs pass through the breast more easily than afterwards when milk is produced. Then lipid-soluble drugs cross in higher concentrations. The effect on nursing infants is dependent on the amount excreted into the milk, the total amount absorbed by the infant, and the toxicity of the drug. The use of the following drugs in breast feeding mothers is reviewed: anticoagulants, antihypertensives and diuretics, antimicrobials, drugs affecting the central nervous system (alcohol, chloral hydrate, meprobamate, lithium, and aspirin), marijuana, other drugs (antihistamines, atropine, ergot alkaloids, laxatives, nicotine, iodides, propylthiouracil, theophylline), hormones (insulin, thyroxine, and oral contraceptives), and radiopharmaceuticals.
Full Text Available ... RSS Menu Home Drugs of Abuse Commonly Abused Drugs Charts Emerging Trends and Alerts Alcohol Club Drugs Cocaine Fentanyl Hallucinogens Inhalants Heroin Marijuana MDMA (Ecstasy/ ...
Older people are major consumers of drugs and because of this, as well as co-morbidity and age-related changes in pharmacokinetics and pharmacodynamics, are at risk of associated adverse drug reactions. While age does not alter drug absorption in a clinically significant way, and age-related changes in volume of drug distribution and protein binding are not of concern in chronic therapy, reduction in hepatic drug clearance is clinically important. Liver blood flow falls by about 35% between young adulthood and old age, and liver size by about 24-35% over the same period. First-pass metabolism of oral drugs avidly cleared by the liver and clearance of capacity-limited hepatically metabolized drugs fall in parallel with the fall in liver size, and clearance of drugs with a high hepatic extraction ratio falls in parallel with the fall in hepatic blood flow. In normal ageing, in general, activity of the cytochrome P450 enzymes is preserved, although a decline in frail older people has been noted, as well as in association with liver disease, cancer, trauma, sepsis, critical illness and renal failure. As the contribution of age, co-morbidity and concurrent drug therapy to altered drug clearance is impossible to predict in an individual older patient, it is wise to start any drug at a low dose and increase this slowly, monitoring carefully for beneficial and adverse effects.
Wilford, B B
An estimated 3% of the United States population deliberately misuse or abuse psychoactive medications, with severe consequences. According to the National Institute on Drug Abuse, more than half of patients who sought treatment or died of drug-related medical problems in 1989 were abusing prescription drugs. Physicians who contribute to this problem have been described by the American Medical Association as dishonest--willfully misprescribing for purposes of abuse, usually for profit; disabled by personal problems with drugs or alcohol; dated in their knowledge of current pharmacology or therapeutics; or deceived by various patient-initiated fraudulent approaches. Even physicians who do not meet any of these descriptions must guard against contributing to prescription drug abuse through injudicious prescribing, inadequate safeguarding of prescription forms or drug supplies, or acquiescing to the demands or ruses used to obtain drugs for other than medical purposes. PMID:2349801
The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user. Based on anecdotal evidence, most people “party” during extended time away from the work environment. Therefore, the following scenarios were envisioned: (1) a person uses an illicit drug at a party on Saturday night (infrequent user); (2) a person uses a drug one time on Friday night and once again on Saturday night (infrequent user); and (3) a person uses a drug on Friday night, uses a drug twice on Saturday night, and once again on Sunday (frequent user).
Taylor, Richard D; MacCoss, Malcolm; Lawson, Alastair D G
We have analyzed the rings, ring systems, and frameworks in drugs listed in the FDA Orange Book to understand the frequency, timelines, molecular property space, and the application of these rings in different therapeutic areas and target classes. This analysis shows that there are only 351 ring systems and 1197 frameworks in drugs that came onto the market before 2013. Furthermore, on average six new ring systems enter drug space each year and approximately 28% of new drugs contain a new ring system. Moreover, it is very unusual for a drug to contain more than one new ring system and the majority of the most frequently used ring systems (83%) were first used in drugs developed prior to 1983. These observations give insight into the chemical novelty of drugs and potentially efficient ways to assess compound libraries and develop compounds from hit identification to lead optimization and beyond.
Danchev, N; Astrug, A; Tsankova, V; Nikolova, I
The use of drugs in pregnancy is being discussed. The influence of different factors, both physiological and drug related (physicochemical characteristics, dose, duration of pharmacotherapy) on the processes of absorption, distribution, protein binding, metabolism and excretion are reviewed. The up-to-date classification of the drugs in relation to their effects on the fetus is presented. Special emphasize is given to drugs (antibiotics, cardio-vascular, psychotropic etc.) used for the treatment of acute and chronic conditions in the course of pregnancy. Drugs used for symptoms like pain, high temperature and constipation are also reviewed. Recommendations for the use of safer drugs in pregnancy are given. Drugs with proven teratogenic effects are presented.
Derrida, in the interview Rhetoric of Drugs (1993), following on from the explication of the notion of pharmakon (both poison and beneficial drug, at the same time), outlines a possible ï¿½theoryï¿½ of drugs and addiction. It has several key features:\\ud ï¿½ there are no drugs in nature: the definition of ï¿½drugï¿½ is an institutionalised one\\ud ï¿½ the concept of drugs is non-scientific, non-positive\\ud ï¿½ drugs are a parasitism ï¿½at once accidental and essentialï¿½; and are thus a topic ...
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This page lists cancer drugs approved by the Food and Drug Administration (FDA) for esophageal cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for liver cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Kaposi sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) to prevent vaginal cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for vulvar cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Wilms tumor and other childhood kidney cancers. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bone cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for penile cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for endometrial cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.
Full Text Available ... the Link - Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors ... GA: CDC, DHHS. Retrieved November 2017. How are Drug Misuse and HIV Related? Drug misuse and addiction ...
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Vishvakarama Prabhakar; Agarwal Shivendra; Sharma Ritika; Saurabh Sharma
Various new technologies have been developed for the transdermal delivery of some important drugs. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involve...
Laitinen, Riikka; Löbmann, Korbinian; Grohganz, Holger
of the bioavailability of poorly water-soluble drugs by increasing the driving force for drug absorption. However, ASDs often require a high weight percentage of carrier (usually a hydrophilic polymer) to ensure molecular mixing of the drug in the carrier and stabilization of the supersaturated state, often leading......Amorphous solid dispersions (ASDs) are probably the most common and important supersaturating drug delivery systems for the formulation of poorly water-soluble compounds. These delivery systems are able to achieve and maintain a sustained drug supersaturation which enables improvement...... strategy for poorly-soluble drugs. While the current research on co-amorphous formulations is focused on preparation and characterization of these systems, more detailed research on their supersaturation and precipitation behavior and the effect of co-formers on nucleation and crystal growth inhibition...
Albertson, Timothy E
The use of recreational drugs of abuse continues to expand without limitations to national boundaries, social status, race, or education. Beyond the prevalence of illicit drug use and dependence, their contribution to the global burden of disease and death are large and troubling. All medical providers should be aware of the evolving drugs of abuse and their medical and social consequences. In addition to heroin and stimulants such as cocaine and methamphetamine, new designer stimulants called "bath salts" and cannabinoids called "spice," along with the abuse of prescription drugs and volatile substances, are now widely recognized problems in many societies. The wide variety and continuingly expanding clinical manifestations of toxicity of recreational drugs of abuse is not widely appreciated by clinicians. This edition attempts to summarize six major classes of drugs of abuse and their clinical effects with special emphasis on their immunological and respiratory effects.
Full Text Available Schizophrenia is a severe psychiatric disorder often associated with cognitive impairment and affective, mainly depressive, symptoms. Antipsychotic medication is the primary intervention for stabilization of acute psychotic episodes and prevention of recurrences and relapses in patients with schizophrenia. Typical antipsychotics, the older class of antipsychotic agents, are currently used much less frequently than newer atypical antipsychotics. Therapeutic drug monitoring (TDM of antipsychotic drugs is the specific method of clinical pharmacology, which involves measurement of drug serum concentrations followed by interpretation and good cooperation with the clinician. TDM is a powerful tool that allows tailor-made treatment for the specific needs of individual patients. It can help in monitoring adherence, dose adjustment, minimizing the risk of toxicity and in cost-effectiveness in the treatment of psychiatric disorders. The review provides complex knowledge indispensable to clinical pharmacologists, pharmacists and clinicians for interpretation of TDM results.
Zhao, Hong-Ping; Jiang, Hong-Min; Xiang, Bing-Ren
The continued high rate of cardiovascular morbidity and mortality has attracted wide concern and great attention of pharmaceutical industry. In order to reduce the attrition of cardiovascular drug R&D, it might be helpful recapitulating previous failures and identifying the potential factors to success. This perspective mainly analyses the 30 cardiovascular drugs dropped from clinical development in 2012. Reasons causing the termination of the cardiovascular drugs in the past 5 years are also tabulated and analysed. The analysis shows that the attrition is highest in Phase II trials and financial and strategic factors and lack of clinical efficacy are the principal reasons for these disappointments. To solve the four problems (The 'better than the Beatles' problem, the 'cautious regulator' problem, the 'throw money at it' tendency and the 'basic researchbrute force' bias) is recommended as the main measure to increase the number and quality of approvable products.
Wilford, B B
An estimated 3% of the United States population deliberately misuse or abuse psychoactive medications, with severe consequences. According to the National Institute on Drug Abuse, more than half of patients who sought treatment or died of drug-related medical problems in 1989 were abusing prescription drugs. Physicians who contribute to this problem have been described by the American Medical Association as dishonest--willfully misprescribing for purposes of abuse, usually for profit; disable...
To ensure proper radioactive drug use (such as quality, diagnostic improvement, and minimal radioactive exposure), the Food and Drug Administration evaluates new drugs with respect to safety, effectiveness, and accuracy and adequacy of the labeling. The IND or NDA process is used for this purpose. A brief description of the process, including the Chemical Classification System and the therapeutic potential classification, is presented as it applies to radiopharmaceuticals. Also, the status of the IND or NDA review of radiopharmaceuticals is given
Salhotra, V S
A strong drug procurement and management system under the RNTCP is critical to programme success. Significant improvements in manufacturing, inspection, supply, storage and quality control practices and procedures have been achieved due to an intensive RNTCP network. Drugs used in RNTCP are rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin. Patients of TB are categorised into I, II and III and each category has a different standarised treatment. Procurement, distribution system and quality assurance of drugs are narrated in brief in this article.
Since the late 1980s, grapefruit juice has been known to affect the metabolism of certain drugs. Several serious adverse effects involving drug interactions with grapefruit juice have been published in detail. The components of grapefruit juice vary considerably depending on the variety, maturity and origin of the fruit, local climatic conditions, and the manufacturing process. No single component accounts for all observed interactions. Other grapefruit products are also occasionally implicated, including preserves, lyophylised grapefruit juice, powdered whole grapefruit, grapefruit seed extract, and zest. Clinical reports of drug interactions with grapefruit juice are supported by pharmacokinetic studies, each usually involving about 10 healthy volunteers, in which the probable clinical consequences were extrapolated from the observed plasma concentrations. Grapefruit juice inhibits CYP3A4, the cytochrome P450 isoenzyme most often involved in drug metabolism. This increases plasma concentrations of the drugs concerned, creating a risk of overdose and dose-dependent adverse effects. Grapefruit juice also inhibits several other cytochrome P450 isoenzymes, but they are less frequently implicated in interactions with clinical consequences. Drugs interacting with grapefruit and inducing serious clinical consequences (confirmed or very probable) include: immunosuppressants, some statins, benzodiazepines, most calcium channel blockers, indinavir and carbamazepine. There are large inter-individual differences in enzyme efficiency. Along with the variable composition of grapefruit juice, this makes it difficult to predict the magnitude and clinical consequences of drug interactions with grapefruit juice in a given patient. There is increasing evidence that transporter proteins such as organic anion transporters and P-glycoprotein are involved in interactions between drugs and grapefruit juice. In practice, numerous drugs interact with grapefruit juice. Although only a few
.... The thesis argues that Haiti's geographic location, political culture, illegal immigrants, entrepreneurial class and weak institutions have made it a major transshipment point for drugs to the United...
Dressler, J; Müller, E
Germany was divided into two parts after World War II. The closed border and a nonconvertible currency in the Eastern part were the factors that did not allow a drug market to develop. Alcohol and medicaments were used as substitute drugs. Since Germany was reunified 5 years ago, there are now the same conditions prevailing for the procurement and sale of drugs in East Germany as there are in the Western German states. This report describes the current state of drug traffic, especially in Saxony, under the new social conditions.
PEOPLE AND DRUGS II. Author: Križanová L. Tutor: Práznovcová L. Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: It is necessary to rationalize the system of funding of health service. One of the ways how to achieve this aim is monitoring of drug prescription and patient's financial participation on the therapy. Aim of study: Observation and analysis of drug prescription aimed at the prescription of the drug...
Schaefer-Prokop, Cornelia; Eisenhuber, Edith
There is an ever increasing number of drugs that can cause lung disease. Imaging plays an important role in the diagnosis, since the clinical symptoms are mostly nonspecific. Various HRCT patterns can be correlated - though with overlaps - to lung changes caused by certain groups of drugs. Alternative diagnosis such as infection, edema or underlying lung disease has to be excluded by clinical-radiological means. Herefore is profound knowledge of the correlations of drug effects and imaging findings essential. History of drug exposure, suitable radiological findings and response to treatment (corticosteroids and stop of medication) mostly provide the base for the diagnosis. (orig.)
Jónasson, Sævar Þór; Zhurbenko, Vitaliy; Johansen, Tom Keinicke
In this work, the microwave radiation is adopted for remote activation of pharmaceutical drug capsules inside the human body in order to release drugs at a pre-determined time and location. An array of controllable transmitting sources is used to produce a constructive interference at a certain...... focus point inside the body, where the drugs are then released from the specially designed capsules. An experimental setup for microwave activation has been developed and tested on a body phantom that emulates the human torso. A design of sensitive receiving structures for integration with a drug...
Hoffman, James M; Shah, Nilay D; Vermeulen, Lee C; Doloresco, Fred; Martin, Patrick K; Blake, Sharon; Matusiak, Linda; Hunkler, Robert J; Schumock, Glen T
Drug expenditure trends in 2007 and 2008, projected drug expenditures for 2009, and factors likely to influence drug expenditures are discussed. Various factors are likely to influence drug expenditures in 2009, including drugs in development, the diffusion of new drugs, drug safety concerns, generic drugs, Medicare Part D, and changes in the drug supply chain. The increasing availability of important generic drugs and drug safety concerns continue to moderate growth in drug expenditures. The drug supply chain remains dynamic and may influence drug expenditures, particularly in specialized therapeutic areas. Initial data suggest that the Medicare Part D benefit has influenced drug expenditures, but the ultimate impact of the benefit on drug expenditures remains unclear. From 2006 to 2007, total U.S. drug expenditures increased by 4.0%, with total spending rising from $276 billion to $287 billion. Drug expenditures in clinics continue to grow more rapidly than in other settings, with a 9.9% increase from 2006 to 2007. Hospital drug expenditures increased at a moderate rate of only 1.6% from 2006 to 2007; through the first nine months of 2008, hospital drug expenditures increased by only 2.8% compared with the same period in 2007. In 2009, we project a 0-2% increase in drug expenditures in outpatient settings, a 1-3% increase in expenditures for clinic-administered drugs, and a 1-3% increase in hospital drug expenditures.
David R. Mottram
Full Text Available This new edition includes fresh information regarding drugs use and abuse in sport and the updated worldwide anti-doping laws, and changes to the prohibited and therapeutic use exemption lists. The objectives of the book are to review/discuss the latest information on drugs in sport by considering i actions of drugs and hormones, ii medication and nutritional supplements in sport, iii the latest doping control regulations of the WADA, iv the use of banned therapeutic drugs in sport, v an assessment of the prevalence of drug taking in sport. FEATURES A common, uniform strategy and evidence-based approach to organizing and interpreting the literature is used in all chapters. This textbook is composed of twelve parts with sub-sections in all of them. The topics of the parts are: i An introduction to drugs and their use in sport, ii Drug use and abuse in sport, iii Central nervous system stimulants, iv WADA regulations in relation to drugs used in the treatment of respiratory tract disorders, v Androgenic anabolic steroids, vi Peptide and glycoprotein hormones and sport, vii Blood boosting and sport, viii Drug treatment of inflammation in sports injuries, ix Alcohol, anti-anxiety drugs and sport, x Creatine, xi Doping control and sport, xii Prevalence of drug misuse in sport. Each specific chapter has been systematically developed from the data available in prospective, retrospective, case-control, and cross-sectional studies. The tables and figures are numerous, helpful and very useful. AUDIENCE The book provides a very useful resource for students on sports related courses, coaches and trainers, researchers, nutritionists, exercise physiologists, pharmacologists, healthcare professionals in the fields of sports medicine and those involved in the management and administration side of sport. The readers are going to discover that this is an excellent reference book. Extensively revised new edition of this book is also a first-rate resource for
Scott, Victor F.
Millions of people in this country take medications, and millions drink alcohol. Both are drugs and have effects on the organs and systems with which they or their metabolites come in contact. This short article discusses some of the combined effects of prescribed drugs and alcohol on some systems, with special emphasis on the liver. PMID:712865
Tønnesen, H H
The number of drugs that are found to be photochemically unstable or able to induce phototoxic side-effects is steadily increasing. It can be difficult, however, to obtain relevant information on the photoreactivity of drugs or drug products from the commonly used handbooks. This is because of lack of standard methods of evaluation or a requirement for official specifications for a given product. The author points to the main problems connected with interactions between drugs and light in vitro and in vivo. The most obvious result of exposure to light is reduced potency of the drug because of photodecomposition. Adverse effects due to the formation of photodegradation products during storage and use have also been reported. The drug substance can further cause light-induced side-effects after administration to the patient, e.g. phototoxicity and photoallergy. More data on photoreactivity are needed in order to minimize the side-effects of frequently used drugs. The article includes a list of potential photosensitizing drug substances on the Norwegian market.
Sutter, M E; Chenoweth, J; Albertson, T E
The incidence of drug abuse with alternative agents is increasing. The term "alternative drugs of abuse" is a catch-all term for abused chemicals that do not fit into one of the classic categories of drugs of abuse. The most common age group abusing these agents range from 17 to 25 years old and are often associated with group settings. Due to their diverse pharmacological nature, legislative efforts to classify these chemicals as a schedule I drug have lagged behind the development of new alternative agents. The potential reason for abuse of these agents is their hallucinogenic, dissociative, stimulant, anti-muscarinic, or sedative properties. Some of these drugs are easily obtainable such as Datura stramonium (Jimson Weed) or Lophophora williamsii (Peyote) because they are natural plants indigenous to certain regions. The diverse pharmacology and clinical effects of these agents are so broad that they do not produce a universal constellation of signs and symptoms. Detailed physical exams are essential for identifying clues leading one to suspect an alternative drug of abuse. Testing for the presence of these agents is often limited, and even when available, the results do not return in a timely fashion. Intoxications from these agents pose unique challenges for health care providers. Physician knowledge of the physiological effects of these alternative agents and the local patterns of drug of abuse are important for the accurate diagnosis and optimal care of poisoned patients. This review summarizes the current knowledge of alternative drugs of abuse and highlights their clinical presentations.
Sep 29, 2013 ... Abstract. Drug-induced aseptic meningitis (DIAM) is a rare but important and often challenging diagnosis for the physician. Intake of antimicrobials, steroids, anal- gesics amongst others has been implicated. Signs and symptoms generally develop within 24-48 hours of drug ingestion. The pa- tient often ...
Nowlis, Helen H.
This paper discusses the nature and extent of student drug use, its meaning and significance, society's response to it, and some of the problems resulting from efforts to control it. Drugs are any substance which by its chemical nature affects the structure or function of the living organism. Abuse refers to any use of a non-medically approved…
Breitkreutz, Jörg; Boos, Joachim
Paediatric drug delivery is a major challenge in drug development. Because of the heterogeneous nature of the patient group, ranging from newborns to adolescents, there is a need to use appropriate excipients, drug dosage forms and delivery devices for different age groups. So far, there is a lack of suitable and safe drug formulations for children, especially for the very young and seriously ill patients. The new EU legislation will enforce paediatric clinical trials and drug development. Current advances in paediatric drug delivery include interesting new concepts such as fast-dissolving drug formulations, including orodispersible tablets and oral thin strips (buccal wafers), and multiparticulate dosage forms based on mini-tabletting or pelletization technologies. Parenteral administration is likely to remain the first choice for children in the neonatal period and for emergency cases. Alternative routes of administration include transdermal, pulmonary and nasal drug delivery systems. A few products are already available on the market, but others still need further investigations and clinical proof of concept.
Katz, David F; Yuan, Andrew; Gao, Yajing
This review presents and applies fundamental mass transport theory describing the diffusion and convection driven mass transport of drugs to the vaginal environment. It considers sources of variability in the predictions of the models. It illustrates use of model predictions of microbicide drug concentration distribution (pharmacokinetics) to gain insights about drug effectiveness in preventing HIV infection (pharmacodynamics). The modeling compares vaginal drug distributions after different gel dosage regimens, and it evaluates consequences of changes in gel viscosity due to aging. It compares vaginal mucosal concentration distributions of drugs delivered by gels vs. intravaginal rings. Finally, the modeling approach is used to compare vaginal drug distributions across species with differing vaginal dimensions. Deterministic models of drug mass transport into and throughout the vaginal environment can provide critical insights about the mechanisms and determinants of such transport. This knowledge, and the methodology that obtains it, can be applied and translated to multiple applications, involving the scientific underpinnings of vaginal drug distribution and the performance evaluation and design of products, and their dosage regimens, that achieve it. Copyright © 2015 Elsevier B.V. All rights reserved.
McGrath, J C; Cowan, D A
This themed issue of the British Journal of Pharmacology has been compiled and edited by Ian McGrath, Regius Professor of Physiology at University of Glasgow and David Cowan, Director of the Drug Control Centre at King's College London. It contains 11 articles covering the mechanisms of action of the major groups of drugs used illicitly in sport. The articles, written by experts in how drugs work, set out where drugs can or cannot affect sporting performance, how this relates to their legitimate medicinal use, their other detrimental effects and how they can be detected. Publication coincides with Olympic year, when sport is highlighted in the public mind and much speculation is made concerning the use of drugs. The articles provide a framework of expert, accurate knowledge to inform and facilitate these debates and to help to overcome the ill-informed and dangerous anecdotal information by which sports men and women are persuaded to misuse drugs in the mistaken belief that this will improve their performance without present or future ill effects. A unique article is included by the Spedding brothers, Mike with a long career in drug discovery and Charlie, the 1984 Los Angeles Olympic Marathon Bronze Medallist and still the English National Marathon record holder. From their unique experience, they describe the insidious and unfair way that drug-assisted performance undermines the ethos of sport and endangers the vital place of sport in maintaining the health of the population.
Abhay Singh Chauhan
Full Text Available Dendrimers have come a long way in the last 25 years since their inception. Originally created as a wonder molecule of chemistry, dendrimer is now in the fourth class of polymers. Dr. Donald Tomalia first published his seminal work on Poly(amidoamine (PAMAM dendrimers in 1985. Application of dendrimers as a drug delivery system started in late 1990s. Dendrimers for drug delivery are employed using two approaches: (i formulation and (ii nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach. We have demonstrated the utility of PAMAM dendrimers for enhancing solubility, stability and oral bioavailability of various drugs. Drug entrapment and drug release from dendrimers can be controlled by modifying dendrimer surfaces and generations. PAMAM dendrimers are also shown to increase transdermal permeation and specific drug targeting. Dendrimer platforms can be engineered to attach targeting ligands and imaging molecules to create a nanodevice. Dendrimer nanotechnology, due to its multifunctional ability, has the potential to create next generation nanodevices.
Kirkegaard, Henriette Schultz; Valentin, Finn
Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...
Marcio C. Mancini
Full Text Available Pharmacological treatment of obesity is an area of sudden changes,development of new drugs and treatment propositions. This articlepresents information on physiological agents that are currentlybeing used as well as drugs that were widely used but are nomore available.
Expectant parents are introduced to the effects of a variety of drugs on the unborn baby. Material is divided into seven sections. Section 1 deals with the most frequently used recreational drugs, including alcohol, marijuana, narcotics, depressants, stimulants, inhalants, and hallucinogens. Sections 2 and 3 focus on the effects of prescription…
Western Center for Drug-Free Schools and Communities.
The Drug Impact Index provides a set of indicators designed to determine the extent of the local drug problem in a community. Each indicator includes a technical note on the data sources, a graph showing comparative statistics on that indicator for the Portland area and for the State of Oregon, and brief remarks on the implications of the data.…
Elderly patients often suffer from a variety of diseases and therefore may be prescribed several kinds of drugs. Interactions between these drugs may cause problems in some patients. Guidelines for drug interactions were released on July 8, 2014 "Drug Interaction Guideline for Drug Development and Labeling Recommendations (Final Draft)". These guidelines include the theoretical basis for evaluating the mechanisms of drug interaction, the possible extent of drug interactions, and take into consideration special populations (e.g., infants, children, elderly patients, patients with hepatic or renal dysfunction, and subjects with minor deficient alleles for drug metabolizing enzymes and drug transporters). In this symposium article, I discuss this last special population: altered drug metabolism and drug interactions in subjects with minor alleles of genes encoding deficient drug metabolizing enzymes. I further discuss a drug label for eliglustat (Cerdelga) with instructions for patients with ultra-rapid, extensive, intermediate, and poor metabolizer phenotypes that arise from different CYP2D6 gene alleles.
Rhodes, Tim; Bernays, Sarah; Houmøller, Kathrin
Parents who use drugs parent in a context of heightened concern regarding the damaging effects of parental drug use on child welfare and family life. Yet there is little research exploring how parents who use drugs account for such damage and its limitation. We draw here upon analyses of audio......-recorded depth qualitative interviews, conducted in south-east England between 2008 and 2009, with 29 parents who use drugs. Our approach to thematic analysis treated accounts as co-produced and socially situated. An over-arching theme of accounts was 'damage limitation'. Most damage limitation work centred...... on efforts to create a sense of normalcy of family life, involving keeping drug use secret from children, and investing heavily in strategies to maintain ambiguity regarding children's awareness. Our analysis highlights that damage limitation strategies double-up in accounts as resources of child protection...
Ramana, Pranov; Adams, Erwin; Augustijns, Patrick; Van Schepdael, Ann
Metabolites as an end product of metabolism possess a wealth of information about altered metabolic control and homeostasis that is dependent on numerous variables including age, sex, and environment. Studying significant changes in the metabolite patterns has been recognized as a tool to understand crucial aspects in drug development like drug efficacy and toxicity. The inclusion of metabonomics into the OMICS study platform brings us closer to define the phenotype and allows us to look at alternatives to improve the diagnosis of diseases. Advancements in the analytical strategies and statistical tools used to study metabonomics allow us to prevent drug failures at early stages of drug development and reduce financial losses during expensive phase II and III clinical trials. This chapter introduces metabonomics along with the instruments used in the study; in addition relevant examples of the usage of metabonomics in the drug development process are discussed along with an emphasis on future directions and the challenges it faces.
Pan, Huo Ping; Fouts, James R.
Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of birds were used. Large species differences in drug metabolism exist between birds and mammals as well as between various birds, these differences were mostly quantitative. Qualitative differences were rare. On the whole, drug metabolism studies in birds have been neglected as compared with similar studies on insects and mammals. The uniqueness of birds and the advantages of using birds in drug metabolism studies are discussed. Possible future studies of drug metabolism in birds are recommended.
A. A. Kubanov
Full Text Available Leprosy (Hansen’s disease is a chronic granulomatous bacterial infection mainly affecting the skin and peripheral nervous system yet also involving other organs and systems as a result of a pathological process. The causative agent of leprosy - Mycobacterium leprae - is an obligate intracellular microorganism. Despite the removal of a threat of a leprosy epidemic, European countries still record outbreaks of the disease mainly among migrants coming from endemic areas. A golden standard of the treatment of leprosy is a WHO-recommended combined drug therapy comprising drugs such as dapsone, clofazimine and rifampicin. The article provides current data on the mechanisms of action, efficacy and safety of these drugs and their combined scheme of treatment obtained as a result of clinical trials. Moreover, it also reviews new regimens of the drug therapy of leprosy including those with the use of drugs from the group of fluoroquinols as well as immunotherapy of the disease.
Kaiser, Ulrich; Mendez, Susan J.; Rønde, Thomas
Reference price systems for prescription drugs have found widespread use as cost containment tools. Under such regulatory regimes, patients co-pay a fraction of the difference between pharmacy retail price of the drug and a reference price. Reference prices are either externally (based on drug...... prices in other countries) or internally (based on domestic drug prices) determined. In a recent study, we analysed the effects of a change from external to internal reference pricing in Denmark in 2005, finding that the reform led to substantial reductions in prices, producer revenues, and expenditures...... for patients and the health insurance system. We also estimated an increase in consumer welfare but the size effect depends on whether or not perceived quality differences between branded and other drugs are taken into account....
Morard, Isabelle; Hadengue, Antoine
Diarrhea is a frequent adverse event involving the most frequently antibiotics, laxatives and NSAI. Drug induced diarrhea may be acute or chronic. It may be due to expected, dose dependant properties of the drug, to immuno-allergic or bio-genomic mechanisms. Several pathophysiological mechanisms have been described resulting in osmotic, secretory or inflammatory diarrhea, shortened transit time, or malabsorption. Histopathological lesions sometimes associated with drug induced diarrhea are usually non specific and include ulcerations, inflammatory or ischemic lesions, fibrous diaphragms, microscopic colitis and apoptosis. The diagnosis of drug induced diarrhea, sometimes difficult to assess, relies on the absence of other obvious causes and on the rapid disappearance of the symptoms after withdrawal of the suspected drug.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for cervical cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for testicular cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for myeloproliferative neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.
Concurrent use of herbs may mimic, magnify, or oppose the effect of drugs. Plausible cases of herb-drug interactions include: bleeding when warfarin is combined with ginkgo (Ginkgo biloba), garlic (Allium sativum), dong quai (Angelica sinensis), or danshen (Salvia miltiorrhiza); mild serotonin syndrome in patients who mix St John's wort (Hypericum perforatum) with serotonin-reuptake inhibitors; decreased bioavailability of digoxin, theophylline, cyclosporin, and phenprocoumon when these drugs are combined with St John's wort; induction of mania in depressed patients who mix antidepressants and Panax ginseng; exacerbation of extrapyramidal effects with neuroleptic drugs and betel nut (Areca catechu); increased risk of hypertension when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe); potentiation of oral and topical corticosteroids by liquorice (Glycyrrhiza glabra); decreased blood concentrations of prednisolone when taken with the Chinese herbal product xaio chai hu tang (sho-salko-to); and decreased concentrations of phenytoin when combined with the Ayurvedic syrup shankhapushpi. Anthranoid-containing plants (including senna [Cassia senna] and cascara [Rhamnus purshiana]) and soluble fibres (including guar gum and psyllium) can decrease the absorption of drugs. Many reports of herb-drug interactions are sketchy and lack laboratory analysis of suspect preparations. Health-care practitioners should caution patients against mixing herbs and pharmaceutical drugs.
Full Text Available Claudia L Reardon, Shane Creado Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Abstract: Drug abuse occurs in all sports and at most levels of competition. Athletic life may lead to drug abuse for a number of reasons, including for performance enhancement, to self-treat otherwise untreated mental illness, and to deal with stressors, such as pressure to perform, injuries, physical pain, and retirement from sport. This review examines the history of doping in athletes, the effects of different classes of substances used for doping, side effects of doping, the role of anti-doping organizations, and treatment of affected athletes. Doping goes back to ancient times, prior to the development of organized sports. Performance-enhancing drugs have continued to evolve, with “advances” in doping strategies driven by improved drug testing detection methods and advances in scientific research that can lead to the discovery and use of substances that may later be banned. Many sports organizations have come to ban the use of performance-enhancing drugs and have very strict consequences for people caught using them. There is variable evidence for the performance-enhancing effects and side effects of the various substances that are used for doping. Drug abuse in athletes should be addressed with preventive measures, education, motivational interviewing, and, when indicated, pharmacologic interventions. Keywords: doping, athletes, steroids, drug abuse, mental illness
Miyamoto, Shingo; Yamada, Manabu; Kasai, Yasuyo; Miyauchi, Akito; Andoh, Kazumichi
Although cancer diagnoses during pregnancy are rare, they have been increasing with the rise in maternal age and are now a topic of international concern. In some cases, the administration of chemotherapy is unavoidable, though there is a relative paucity of evidence regarding the administration of anticancer drugs during pregnancy. As more cases have gradually accumulated and further research has been conducted, we are beginning to elucidate the appropriate timing for the administration of chemotherapy, the regimens that can be administered with relative safety, various drug options and the effects of these drugs on both the mother and fetus. However, new challenges have arisen, such as the effects of novel anticancer drugs and the desire to bear children during chemotherapy. In this review, we outline the effects of administering cytotoxic anticancer drugs and molecular targeted drugs to pregnant women on both the mother and fetus, as well as the issues regarding patients who desire to bear children while being treated with anticancer drugs. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: email@example.com.
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Full Text Available ... www.cdc.gov/actagainstaids/basics/whatishiv.html ). Atlanta, GA: CDC, DHHS. Retrieved November 2017. How are Drug ... lead people to engage in impulsive and unsafe behaviors. Injection drug use. People typically associate drug misuse ...
Full Text Available ... or reduce their drug use and related risk behaviors, including drug injection and unsafe sexual practices. Drug use disorder treatment programs also serve an important role in providing ...
Full Text Available ... risk for getting HIV. Drug and alcohol intoxication affect judgment and can lead to unsafe sexual practices, ... effects of drugs. Drug misuse and addiction can affect a person's overall health, thereby altering susceptibility to ...
Full Text Available ... is partly due to the addictive and intoxicating effects of many drugs, which can alter judgment and ... HIV or transmitting it to someone else. Biological effects of drugs. Drug misuse and addiction can affect ...
U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...
Full Text Available ... Twitter YouTube Flickr RSS Menu Home Drugs of Abuse Commonly Abused Drugs Charts Emerging Trends and Alerts ... to HIV and progression of AIDS. Drugs of abuse and HIV both affect the brain. Research has ...
U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...
U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for pancreatic cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for lung cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bladder cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.
Full Text Available ... Commonly Abused Drugs Charts Emerging Trends and Alerts Alcohol Club Drugs Cocaine Fentanyl Hallucinogens Inhalants Heroin Marijuana ... person at risk for getting HIV. Drug and alcohol intoxication affect judgment and can lead to unsafe ...
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Full Text Available ... or reduce their drug use and related risk behaviors, including drug injection and unsafe sexual practices. Drug use disorder treatment programs also serve an important role in ...
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... Ask about Your Treatment Research Drugs Approved for Thyroid Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Thyroid Cancer Cabozantinib-S-Malate Caprelsa (Vandetanib) Cometriq (Cabozantinib-S-Malate) Doxorubicin ...
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Full Text Available ... Home Drugs of Abuse Commonly Abused Drugs Charts Emerging Trends and Alerts Alcohol Club Drugs Cocaine Fentanyl ... AIDS (acquired immune deficiency syndrome). AIDS is a disease of the immune system for which there is ...
Full Text Available D05157 Drug Nicotine polacrilex (USAN); Nicorette (TN) ... Other ... DG01718 ... Drugs... for addictive disorder ... DG01715 ... Drugs for nicotine dependence Cyp substrate ... DG01638 ... CYP2A6 substrate Cy
Full Text Available D00123 Drug Cyanamide (JP17); Cyanamide (TN) ... CH2N2 D00123.gif ... Other ... DG01718 ... Drugs... for addictive disorder ... DG01716 ... Drugs for alcohol dependence Same as: C01566 Therapeutic category: 3
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Full Text Available ... parents and teachers). It provides them with useful information on the science behind drug use. NIDA’s Easy-to-Read Drug Facts Web site describes the dangers of drug misuse and ...
Full Text Available D00330 Drug Flurbiprofen (JP17/USP/INN); Ansaid (TN) ... C15H13FO2 D00330.gif ... Anti...-inflammatory ... DG01908 ... Antiinflammatory drug, propionic acid derivatives ... DG01504 ... Nonsteroidal antiinflammatory drug (NSAI
Ikemoto, Satoshi; Bonci, Antonello
In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmitter systems involved in drug- and reward-related behaviors. Also discussed is a theoretical framework that helps to understand the functional properties of the circuitry involved in these behaviors. The circuitry appears to be homeostatically regulated and mediate anticipatory processes that regulate behavioral interaction with the environment in response to salient stimuli. That is, abused drugs or, at least, some may act on basic motivation and mood processes, regulating behavior-environment interaction. Optogenetics and related technologies have begun to uncover detailed circuit mechanisms linking key brain regions in which abused drugs act for rewarding effects. PMID:23664810
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... June 6, 2018 HIV Vaccine Elicits Antibodies in Animals that Neutralize Dozens of HIV Strains , June 4, 2018 ... Antimicrobial (Drug) Resistance > Understanding share with facebook share with twitter share ...
U.S. Department of Health & Human Services — This page provides background needed to take advantage of the capabilities of the MSIS Drug Utilization Datamart. This mart allows the user to develop high-level...
... help you quit. Or contact: National Council on Alcoholism and Drug Dependence (800) 622-2255 Substance Abuse Treatment Facility Locator (800) 662-4357 Last reviewed: November, 2016 Pregnancy Is it safe? Other Pregnancy topics ') document.write(' ...
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... this page: //medlineplus.gov/ency/patientinstructions/000314.htm Cholesterol - drug treatment To use the sharing features on ... treatment; Hardening of the arteries - statin Statins for Cholesterol Statins reduce your risk of heart disease, stroke, ...
National Association of Student Personnel Administrators, Detroit, MI.
A bibliography of materials on drugs is presented. The book and paper back entries are annotated. Selected technical references are listed under these major findings: (1) dependency, (2) barbiturates, (3) amphetamines, and (4) general pharmacology. (PS)
Full Text Available Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal.
Nitsche, Claudia; Maertin, Sandrina; Scheiber, Jonas; Ritter, Christoph A; Lerch, Markus M; Mayerle, Julia
Drugs are thought to be a rare cause for acute pancreatitis; however 525 different drugs are listed in the World Health Organization (WHO) database suspected to cause acute pancreatitis as a side effect. Many of them are widely used to treat highly prevalent diseases. The true incidence is not entirely clear since only few systematic population based studies exist. The majority of the available data are derived from case reports or case control studies. Furthermore, the causality for many of these drugs remains elusive and for only 31 of these 525 dugs a definite causality was established. Definite proof for causality is defined by the WHO classification if symptoms reoccur upon rechallenge.In the actual algorithm the diagnosis is confirmed if no other cause of acute pancreatitis can be detected, and the patient is taking one of the suspected drugs.
The submission of the first 'smart pill' for market approval, combined with progress in the European nanomedicine landscape, illustrates the positive outlook for drug therapy and health monitoring, explains Christian Martin.
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... Paclitaxel Suramin Vincristine Drugs used to fight infections: Chloroquine Dapsone Isoniazid (INH), used against tuberculosis Metronidazole (Flagyl) ... to treat gout) Disulfiram (used to treat alcohol use) Arsenic Gold Symptoms Symptoms may include any of ...
Silverman, M; Lydecker, M; Lee, P R
In a number of important developing nations--among them Indonesia, India, and Brazil--clinical pharmacologists and other drug experts are revealing mounting concern over the marketing of fraudulent drug products. These are shaped, colored, flavored, marked, and packaged to mimic the real product. They may contain the actual antibiotic or other drug indicated on the label, but so "cut" that the product provides only a small fraction of the labeled amount, or they may contain only useless flour or starch. At best, they are worthless. At the worst, they can kill. In most instances, it is believed that these "drugs" are produced and marketed by local or domestic fly-by-night groups and not by multinational pharmaceutical firms. Blame for these practices is placed on inadequate or unenforced laws, only trivial punishments, bribery and corruption, and the fact that generally "nobody inspects the inspectors."
... this person's face have resulted from drug-induced vitiligo. Loss of melanin, the primary skin pigment, occasionally ... is the case with this individual. The typical vitiligo lesion is flat and depigmented, but maintains the ...
Walsh, J. Michael; De Gier, Johan J.; Christopherson, Asbjørg S.; Verstraete, Alain G.
The authors present a global overview on the issue of drugs and driving covering four major areas: (1) Epidemiology and Prevalence-which reviews epidemiological research, summarizes available information, discusses the methodological shortcomings of extant studies, and makes recommendations for
U.S. Department of Health & Human Services — The Medicaid Drug Claims Statistics CD is a useful tool that conveniently breaks up Medicaid claim counts and separates them by quarter and includes an annual count.
Prausnitz, Mark R.; Langer, Robert
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability ...
Leroy, Clara; Rigot, Jean-Marc; Leroy, Maryse; Decanter, Christine; Le Mapihan, Kristell; Parent, Anne-Sophie; Le Guillou, Anne-Claire; Yakoub-Agha, Ibrahim; Dharancy, Sébastien; Noel, Christian; Vantyghem, Marie-Christine
Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune diseases, as well as in transplantation. Frequently prescribed in young people, these treatments may have deleterious effects on fertility, pregnancy outcomes and the unborn child. This review aims to summarize the main gonadal side effects of immunosuppressants, to detail the effects on fertility and pregnancy of each class of drug, and to provide recommendations on the management of patients who are seen prior ...
Koch, Brendan; Rubino, Ilaria; Quan, Fu-Shi; Yoo, Bongyoung; Choi, Hyo-Jick
This review is devoted to discussing the application of microfabrication technologies to target challenges encountered in life processes by the development of drug delivery systems. Recently, microfabrication has been largely applied to solve health and pharmaceutical science issues. In particular, fabrication methods along with compatible materials have been successfully designed to produce multifunctional, highly effective drug delivery systems. Microfabrication offers unique tools that can tackle problems in this field, such as ease of mass production with high quality control and low cost, complexity of architecture design and a broad range of materials. Presented is an overview of silicon- and polymer-based fabrication methods that are key in the production of microfabricated drug delivery systems. Moreover, the efforts focused on studying the biocompatibility of materials used in microfabrication are analyzed. Finally, this review discusses representative ways microfabrication has been employed to develop systems delivering drugs through the transdermal and oral route, and to improve drug eluting implants. Additionally, microfabricated vaccine delivery systems are presented due to the great impact they can have in obtaining a cold chain-free vaccine, with long-term stability. Microfabrication will continue to offer new, alternative solutions for the development of smart, advanced drug delivery systems. PMID:28773770
Nelson, Michael E; Bryant, Sean M; Aks, Steven E
Many new emerging drugs of abuse are marketed as legal highs despite being labeled "not for human consumption" to avoid regulation. The availability of these substances over the Internet and in "head shops" has lead to a multitude of emergency department visits with severe complications including deaths worldwide. Despite recent media attention, many of the newer drugs of abuse are still largely unknown by health care providers. Slight alterations of the basic chemical structure of substances create an entirely new drug no longer regulated by current laws and an ever-changing landscape of clinical effects. The purity of each substance with exact pharmacokinetic and toxicity profiles is largely unknown. Many of these substances can be grouped by the class of drug and includes synthetic cannabinoids, synthetic cathinones, phenethylamines, as well as piperazine derivatives. Resultant effects generally include psychoactive and sympathomimetic-like symptoms. Additionally, prescription medications, performance enhancing medications, and herbal supplements are also becoming more commonly abused. Most new drugs of abuse have no specific antidote and management largely involves symptom based goal directed supportive care with benzodiazepines as a useful adjunct. This paper will focus on the history, epidemiology, clinical effects, laboratory analysis, and management strategy for many of these emerging drugs of abuse. Copyright © 2014 Elsevier Inc. All rights reserved.
Bratzke, H; Albers, C
In a case of a fatal occupational accident (construction worker, fall from roof, urine test positive for cocaine and THC, e.g. cannabis) the question arised to what extent those drug-related occupational accidents occur. In the literature only few cases, mainly dealing with cannabis influence, have been reported, however, a higher number is suspected. Cocaine and other stimulating drugs (amphetamine) are more often used to increase physical fitness. By direct or indirect interference with vigilance these compounds may provoke accidents. Due to the lack of a legal basis proving of the influence of drugs at the working place is still very limited, although highly sensitive chemical-toxicological assay procedures are available to detect even the chronic abuse (in hair). In the general conditions of accident insurances a compensation is excluded when alcohol is involved, but drugs are not mentioned. It is indeed difficult to establish a concentration limit for drugs like that existing for alcohol (1.1%). In each case the assay of the drug involved and exact knowledge of its specific effects is in an essential prerequisite to prove the causal relationship.
Rech, Megan A; Donahey, Elisabeth; Cappiello Dziedzic, Jacqueline M; Oh, Laura; Greenhalgh, Elizabeth
Drug abuse is a common problem and growing concern in the United States, and over the past decade, novel or atypical drugs have emerged and have become increasingly popular. Recognition and treatment of new drugs of abuse pose many challenges for health care providers due to lack of quantitative reporting and routine surveillance, and the difficulty of detection in routine blood and urine analyses. Furthermore, street manufacturers are able to rapidly adapt and develop new synthetic isolates of older drugs as soon as law enforcement agencies render them illegal. In this article, we describe the clinical and adverse effects and purported pharmacology of several new classes of drugs of abuse including synthetic cannabinoids, synthetic cathinones, salvia, desomorphine, and kratom. Because many of these substances can have severe or life-threatening adverse effects, knowledge of general toxicology is key in recognizing acute intoxication and overdose; however, typical toxidromes (e.g., cholinergic, sympathomimetic, opioid, etc.) are not precipitated by many of these agents. Medical management of patients who abuse or overdose on these drugs largely consists of supportive care, although naloxone may be used as an antidote for desomorphine overdose. Symptoms of aggression and psychosis may be treated with sedation (benzodiazepines, propofol) and antipsychotics (haloperidol or atypical agents such as quetiapine or ziprasidone). Other facets of management to consider include treatment for withdrawal or addiction, nutrition support, and potential for transmission of infectious diseases. © 2014 Pharmacotherapy Publications, Inc.
Full Text Available In this article which is a review of sociological ideas and studies of drug abusers in social situation, drug addiction steps (particularly alcohol, heroin and cocaine consumption are revised and some explanations are made. Also, the role of some sociological ideas in drug addiction is considered in which Anomie Theory reads: "because of such duality, the individuals who are not satisfied with their role are in hurt." According to this theory, drug users choose seclusion and neglecting usual social aims as well as competitive situations. Association of Differentiation Theory claims that drug use behavior is a learned behavior and the first learning occurs in a friendly small group (i.e. youngsters. Social Control theory believes that one can predict normal and abnormal behaviors through the rate of individuals' social commitments. Internal and external controls also determine commitment rate. Micro-cultural theory considers drug use as a compatibility with abnormal micro-culture rules. Symbolic Mutual Action Believes that the etiquettes which society attribute to individuals/behaviors determine their acquired social reactions rather than any inherited acquisition.
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Alcides Jose Sanches Vergara
Full Text Available In this article, we tackle the issue of youth and drugs as something linked to biopower and biopolitics, both concepts developed by Michael Foucault. Youth and drugs are taken and analyzed in situations involving the management of crime linked to the risks and deviations from the law, abuse and dependence. The youth; irreverent, courageous, healthy, idealistic, and that wanted to change the world for the better as we have seen in the past, is now strongly related to violence, dangerous activities, moral and social risks, drug addiction, criminality, and others negative images. To deal with these young people, tolerance and small punishments of yore are not enough anymore. The young people emerge as a segment of the population subject to various actions and programs. The drugs now are seen as matters of security and public health. There is a shifting and repositioning in the discourse about the young - from minor, drugged, and criminal to lawbreaker, user and drug addict. The change is subtle, but represents a modulation in the devices of social control. Beyond the consent of the young to get rid of drugs, there is a search for the creation of a wide area of monitoring of their behavior through the activation of community protection networks. The belief that the young are more impressionable and vulnerable, and that action on the cause of the problem or risk reduction are the most efficient ways of management, taking responsibility away from personal and family sphere and transferring it to the State, contributes to the increasing control of young people nowadays.
theophylline (THP) as drug in drug to clay ratios of 1:2, 3:4 and 1:1. The formulations were characterized for drug release and loading. Dependent and independent kinetic models were employed to analyze the drug release data. Fourier transform infrared spectroscopy (FTIR) was used for the structural characterization of ...
Some challenges associated with the technology as it relates to drug effectiveness, toxicity, stability, pharmacokinetics and drug regulatory control are discussed in this review. Clearly, nanotechnology is a welcome development that is set to transform drug delivery and drug supply chain management, if optimally developed ...
Tao, Da; Wang, Tieyan; Wang, Tieshan; Qu, Xingda
A drug's physical characteristics, such as colour, could be factors influencing its therapeutic effects. It is not well understood whether people's expectations on drug effects and efficacy are affected by colour, especially among Chinese population. This study was conducted to examine people's expectations on drug effects and efficacy on the basis of drug colour, and to reveal possible gender differences in colour-related drug expectations. Participants (n = 224) were asked to classify seven single-coloured and six two-coloured capsules into one of four categories of drug effects, and to indicate the strength of drug efficacy. It is found that all the coloured capsules yielded non-chance distributions in classifications of drug effects, with six single-coloured and four two-coloured capsules associated with specific drug effects. Colour also conveyed differential strengths of drug efficacy in general and in relation to specific drug effects. There were gender differences in drug expectations for some colours and colour combinations. Practitioner Summary: Drug colour was found to have impacts on perceived drug effects and efficacy. The findings from the present study can be used by ergonomics practitioners to design appropriate drug colours in support of drug differentiation, therapeutic effects and medication adherence.
Full Text Available Background: The provision of pharmaceutical drugs is of enormous significance in our lives. Notable progress made inthe domain of Public Health, combined with a general increase in the standard of living, has had a direct impact on thediscovery of new drugs and cures and has shifted pharmaceutical policies further in line with the current needs of boththe country’s health system and, its population.Aim: This research aims to both shed light on and analyse the current state of pharmaceutical policy in Cyprus, as well asto try to seek out its weaknesses, making suggestions, where possible, as to how to keep these to the minimum.Results, and Conclusions: The lack of both high level research and major industrial facilities relating to the discovery ofnew pharmaceutical drugs in Cyprus, has hindered the effectiveness of pharmaceutical policy in general domains such ascontrol over the circulation and production of pharmaceutical products in the country, their pricing and distribution andthe monitoring of our drug supplies. The lack of transparency in a number of pharmaceutical procedures, and ofinformation on drugs does not enhance the industry’s reliability, but rather exacerbates an underlying feeling of insecurityrelating to it among the population.
Full Text Available Drug hypersensitivity syndrome (DHS is an adverse drug reaction commonly associated with the aromatic antiepileptic drugs (AEDs, viz., phenytoin (PHT, carbamazepine (CBZ, phenobarbital (PB, lamotrigine, primidone, etc. It can also be caused by other drugs, such as sulfonamides, dapsone, minocycline, gold derivatives, cyclosporine, captopril, diltiazem, terbinafine, azathioprine and allopurinol. Diagnosis of DHS may be difficult because of the variety of clinical and laboratory abnormalities and manifestations and because the syndrome may mimic infectious, neoplastic or collagen vascular disorders. The risk for developing hypersensitivity within 60 days of the first or second prescription in new users of PHT or CBZ was estimated to be 2.3-4.5 per 10,000 and 1-4.1 per 10,000, respectively. The syndrome is defined by the fever, skin rash, lymphadenopathy and internal organ involvement within the first 2-8 weeks after initiation of therapy. Internal manifestations include, among others, agranulocytosis, hepatitis, nephritis and myositis. Insufficient detoxification may lead to cell death or contribute to the formation of antigen that triggers an immune reaction. Cross-reactivity among PHT, CBZ and PB is as high as 70%-80%. Management mainly includes immediate withdrawal of the culprit drug, symptomatic treatment and systemic steroids or immunoglobulins.
Rondeau, D.B.; Jolicoeur, F.B.; Merkel, A.D.; Wayner, M.J.
The literature on the effects of drugs on the acquisition and the magnitude of taste aversion is reviewed and discussed. Then, the results of a series of experiments on the effects of phenobarbital and related drugs on taste aversion are reported. A standard taste aversion model was used in all experiments; test drugs were injected prior to drinking in a one bottle situation on the first test day following the taste aversion treatment. Phenobarbital in doses ranging from 20 to 80 mg/kg significantly attenuated taste aversion induced by lithium chloride (LiCl) and x-radiation, the maximal effect occurred with the 60 mg/kg dose. The attenuating effect was found to be dependent upon the magnitude of the aversion to the sapid solution. Phenobarbital completely abolished aversion produced by 0.375 mEq LiCl while the attenuation effect decreased linearly with higher doses of LiCl. Results also indicate that phenobarbital's attenuating effect cannot be solely attributed to its dipsogenic characteristic or to its state dependent learning effect. Attenuation of LiCl aversion to a saccharin solution was also observed following single doses of amobarbital, 30 mg/kg, pentobarbital, 15 mg/kg, and chloropromazine, 0.75 mg/kg. Taste aversion was not affected by other doses of those drugs or by hexobarbital, barbital, and chlordiazepoxide. Phenobarbital's attenuating effect on taste aversion is discussed in relation to other known behavioral and neurophysiological effects of the drug
D'Souza, Manoranjan S.
Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a significant burden on healthcare systems all over the world. The positive reinforcing (rewarding) effects of the above mentioned drugs play a major role in the initiation and maintenance of the drug-taking habit. Thus, understanding the neurochemical mechanisms underlying the reinforcing effects of drugs of abuse is critical to reducing the burden of drug addiction in society. Over the last two decades...
Depan, D.; Misra, R.D.K.
We describe here a transformative approach to synthesize a hybrid nanostructured drug carrier that exhibits the characteristics of controlled drug release. The synthesis of the nanohybrid architecture involved two steps. The first step involved direct crystallization of biocompatible copolymer along the long axis of the carbon nanotubes (CNTs), followed by the second step of attachment of drug molecule to the polymer via hydrogen bonding. The extraordinary inorganic–organic hybrid architecture exhibited high drug loading ability and is physically stable even under extreme conditions of acidic media and ultrasonic irradiation. The temperature and pH sensitive characteristics of the hybrid drug carrier and high drug loading ability merit its consideration as a promising carrier and utilization of the fundamental aspects used for synthesis of other promising drug carriers. The higher drug release response during the application of ultrasonic frequency is ascribed to a cavitation-type process in which the acoustic bubbles nucleate and collapse releasing the drug. Furthermore, the study underscores the potential of uniquely combining CNTs and biopolymers for drug delivery. - Graphical abstract: Block-copolymer crystallized on carbon nanotubes (CNTs). Nanohybrid drug carrier synthesized by attaching doxorubicin (DOX) to polymer crystallized CNTs. Crystallized polymer on CNTs provide mechanical stability. Triggered release of DOX. Highlights: ► The novel synthesis of a hybrid nanostructured drug carrier is described. ► The drug carrier exhibits high drug loading ability and is physically stable. ► The high drug release is ascribed to a cavitation-type process.
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Coleman, Michael D
..., both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Office of National Drug Control Policy, Washington, DC.
President Bush's new National Drug Control Strategy for 2003 focuses on three core priorities: stopping drug use before it starts; healing America's drug users; and disrupting the market. The 2003 strategy reports progress toward meeting the President's goals of reducing drug use by 10 percent over 2 years, and 25 percent over 5 years. With regard…
R. Marhe (Reshmi)
textabstractWorldwide, about 35 million people, that is 0.8% of the world’s adult population, use heroin and/or cocaine and more than 10-13% of these drug users are or will become drug dependent (UNODC, World Drug Report, 2012). Drug dependency is characterized as a chronic relapsing disorder
This document presents a revised set of principles for school drug education. The principles for drug education in schools comprise an evolving framework that has proved useful over a number of decades in guiding the development of effective drug education. The first edition of "Principles for Drug Education in Schools" (Ballard et al.…
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van Amsterdam, Jan; Nutt, David; Phillips, Lawrence; van den Brink, Wim
The present paper describes the results of a rating study performed by a group of European Union (EU) drug experts using the multi-criteria decision analysis model for evaluating drug harms. Forty drug experts from throughout the EU scored 20 drugs on 16 harm criteria. The expert group also assessed
Raz, K.; Smolik, S.; Vinarova, M.; Janda, J.; Franc, Z.
The erythro- and threoform of p-hydroxynorephedrine belong to the group of drugs affecting the course of hypertensive disease. For pharmacological studies both forms were labelled with 3 H radionuclide on the benzene ring. 90% of radioactivity was concentrated in the ortho positions with regard to the hydroxyl, 10% in the meta position. After the administration of the labelled drug to rats, rapid absorption occurs and radioactivity is eliminated from the organism, especially in the urine. Three radioactive substances were found in the urine of experimental animals. A substance with properties corresponding to those of the administered drug prevailed. The highest levels of radioactivity in the tissues were found after intravenous administration as early as after 5 minutes after administration, 15 minutes after subcutaneous administration. It was found that p-hydroxynorephedrine significantly restricted the detainment of labelled noradrenaline-7- 3 H in the tissues of premedicated animals. (author)
Harvey, Alan L
Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of failure during development programmes are outlined in order to highlight steps that might be taken to increase the chances of success with toxin-based drug discovery. These include having a clear focus on unmet therapeutic needs, concentrating on targets that are well-validated in terms of their relevance to the disease in question, making use of phenotypic screening rather than molecular-based assays, and working with development partners with the resources required for the long and expensive development process. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.
Angiogenesis or neovascularization, the formation of neo-vessels, is a physiological phenomenon endued in vasculature, but is involved in various pathological conditions. Angiogenesis is required for tumor growth and metastasis, and thus constitutes an important target for the control of tumor progression. Indeed, the recent development of bevacizumab, a neutralizing anti-VEGF monoclonal antibody as the first anti-angiogenic drug, legalized the clinical merit of anti-angiogenesis in cancers. Thereafter, various drugs targeting VEGF-mediated signals have been developed to control tumor angiogenesis. Thus, anti-angiogenic drugs are now recognized in the clinic as a major step forward for the treatment of cancers. This review focuses on the current status of antiangiogenesis treatment in cancers.
Jahnz-Różyk, Karina; Kawalec, Pawel; Malinowski, Krzysztof; Czok, Katarzyna
We presented a general overview of the health care system as well as the pricing and reimbursement environment in Poland. Poland aims to ensure proper access to safe and effective medicines while reducing patients' share in treatment costs. Nevertheless, the co-payment for pharmacotherapy is still high (more than 60%). The key policymaker and regulator in the system is the Ministry of Health, which is supported by the Polish Agency for Health Technology Assessment and Tariff System (Agencja Oceny Technologii Medycznych i Taryfikacji), responsible for evaluating applicant drugs, and the Economic Commission, responsible for negotiating the official sales prices and conditions for reimbursement with pharmaceutical companies (e.g., level of reimbursement and risk-sharing scheme agreements). The Agency for Health Technology Assessment and Tariff System dossier is obligatory for reimbursement application and includes the analysis of clinical effectiveness, economic analysis (with the threshold of quality-adjusted life-year established as no more than 3 times the gross domestic product per capita), and the analysis of budget impact. In Poland, only a positive list of reimbursed drugs is published and it is updated every 2 months. The following levels of reimbursement are in use: 100%, 70%, 50%, and lump sum (about €0.8). The first reimbursement decision is given for a period of 2 years only, the second for 3 years, and the third for 5 years. There is no separate budget or special legal regulations for orphan drugs. Generic substitution of drugs is desired but not mandatory. Physicians are not assigned with pharmaceutical budgets. The access to real-world data is limited; the only registers available are for drugs used in drug programs. Copyright © 2017. Published by Elsevier Inc.
Culig, Josip; Antolic, Sinisa; Szkultecka-Dębek, Monika
We presented a general overview of the health care system as well as the pricing and reimbursement environment in Croatia. In Croatia, most of the public funding for health care is collected from employers, through mandatory health care contributions for all the employed citizens. This contribution is a dedicated tax reserved for the health care system derived from employees' salaries. The rest of the public funds is mainly from taxes used by the Ministry of Finance to complement the overall health budget each year. The population is covered by a basic health insurance plan provided by statute and optional insurance, administered by the Croatian Health Insurance Fund. Reimbursement decisions are based on the Ordinance of Ministry of Health issued in 2013, which is an ordinance establishing the criteria for inclusion of medicinal products in the Croatian Health Insurance Fund basic and supplementary drug lists. A health technology assessment agency was established in 2007 as a legal, public, independent, nonprofit institution under the Act on Quality of Health Care. Budget impact analysis is obligatory, and cost-effectiveness analysis is beneficial. Two reimbursement lists exist: the basic (100% drug coverage) and the supplementary (co-payment from 10% to 90%) lists. The basic list covers both hospital and retail drugs. There is also a special drug list for expensive drugs (mainly hospital drugs). International reference pricing is also in place. List updates are done on an yearly basis. Real-world evidence can be required for health technology assessment as evidence for the budget impact models and cost-effective analysis; it is, however, not mandatory. Copyright © 2017. Published by Elsevier Inc.
Cremers, Serge; Aronson, Jeffrey K
Estimates of the frequencies of rare disorders vary from country to country; the global average defined prevalence is 40 per 100 000 (0.04%). Some occur in only one or a few patients. However, collectively rare disorders are fairly common, affecting 6-8% of the US population, or about 30 million people, and a similar number in the European Union. Most of them affect children and most are genetically determined. Diagnosis can be difficult, partly because of variable presentations and partly because few clinicians have experience of individual rare disorders, although they may be assisted by searching databases. Relatively few rare disorders have specific pharmacological treatments (so-called orphan drugs), partly because of difficulties in designing trials large enough to determine benefits and harms alike. Incentives have been introduced to encourage the development of orphan drugs, including tax credits and research aids, simplification of marketing authorization procedures and exemption from fees, and extended market exclusivity. Consequently, the number of applications for orphan drugs has grown, as have the costs of using them, so much so that treatments may not be cost-effective. It has therefore been suggested that not-for-profit organizations that are socially motivated to reduce those costs should be tasked with producing them. A growing role for patient organizations, improved clinical and translational infrastructures, and developments in genetics have also contributed to successful drug development. The translational discipline of clinical pharmacology is an essential component in drug development, including orphan drugs. Clinical pharmacologists, skilled in basic pharmacology and its links to clinical medicine, can be involved at all stages. They can contribute to the delineation of genetic factors that determine clinical outcomes of pharmacological interventions, develop biomarkers, design and perform clinical trials, assist regulatory decision
Atreya, Ravi V; Sun, Jingchun; Zhao, Zhongming
Drug addiction is a complex and chronic mental disease, which places a large burden on the American healthcare system due to its negative effects on patients and their families. Recently, network pharmacology is emerging as a promising approach to drug discovery by integrating network biology and polypharmacology, allowing for a deeper understanding of molecular mechanisms of drug actions at the systems level. This study seeks to apply this approach for investigation of illicit drugs and their targets in order to elucidate their interaction patterns and potential secondary drugs that can aid future research and clinical care. In this study, we extracted 188 illicit substances and their related information from the DrugBank database. The data process revealed 86 illicit drugs targeting a total of 73 unique human genes, which forms an illicit drug-target network. Compared to the full drug-target network from DrugBank, illicit drugs and their target genes tend to cluster together and form four subnetworks, corresponding to four major medication categories: depressants, stimulants, analgesics, and steroids. External analysis of Anatomical Therapeutic Chemical (ATC) second sublevel classifications confirmed that the illicit drugs have neurological functions or act via mechanisms of stimulants, opioids, and steroids. To further explore other drugs potentially having associations with illicit drugs, we constructed an illicit-extended drug-target network by adding the drugs that have the same target(s) as illicit drugs to the illicit drug-target network. After analyzing the degree and betweenness of the network, we identified hubs and bridge nodes, which might play important roles in the development and treatment of drug addiction. Among them, 49 non-illicit drugs might have potential to be used to treat addiction or have addictive effects, including some results that are supported by previous studies. This study presents the first systematic review of the network
Christiansen, Ask Vest
Taking some of the most significant academic works into consideration this chapter describes how the scholarly interest in drug use in gyms rose from studies of competitive bodybuilding to studies of larger segments of the gym population. The challenge of establishing reliable figures...... for the frequency of anabolic steroid use and describing the typical users is then addressed. Next, the chapter discusses the associated cultural, psychological, and evolutionary explanations for anabolic steroid use in gyms and fitness centres. The chapter concludes with a brief discussion of some...... of the significant political campaigns and strategies to regulate and counter drug use in gyms....
Computer based method can help in discovery of leads and can potentially eliminate chemical synthesis and screening of many irrelevant compounds, and in this way, it save time as well as cost. Molecular modeling systems are powerful tools for building, visualizing, analyzing and storing models of complex molecular structure that can help to interpretate structure activity relationship. The use of various techniques of molecular mechanics and dynamics and software in Computer aided drug design along with statistics analysis is powerful tool for the medicinal chemistry to synthesis therapeutic and effective drugs with minimum side effect.
Weatherall, Mark W
All physicians will encounter patients with headaches. Primary headache disorders are common, and often disabling. This paper reviews the principles of drug therapy in headache in adults, focusing on the three commonest disorders presenting in both primary and secondary care: tension-type headache, migraine and cluster headache. The clinical evidence on the basis of which choices can be made between the currently available drug therapies for acute and preventive treatment of these disorders is presented, and information given on the options available for the emergency parenteral treatment of refractory migraine attacks and cluster headache. © Royal College of Physicians 2015. All rights reserved.
Pau, Alice K; George, Jomy M
The rapid advances in drug discovery and the development of antiretroviral therapy is unprecedented in the history of modern medicine. The administration of chronic combination antiretroviral therapy targeting different stages of the human immunodeficiency virus' replicative life cycle allows for durable and maximal suppression of plasma viremia. This suppression has resulted in dramatic improvement of patient survival. This article reviews the history of antiretroviral drug development and discusses the clinical pharmacology, efficacy, and toxicities of the antiretroviral agents most commonly used in clinical practice to date. Published by Elsevier Inc.
Franc, Z.; Smolik, S.; Horesovsky, O.; Hradil, F.
The kinetics in rats was studied of the tranquilizer noroxyclothepine (8-chloro-10-(4-hydroxyethyl)piperazino-10,11-dihydrobenzo(b,f)-thiepine). The drug was labelled with carbon 14 and the kinetics of the drug was investigated after oral and i.v. administration. It was found that over 4 days, 88 to 99% of radioactivity was excreted in feces and 5.5 to 6% in the urine, this for both ways of administration. Following oral administration, 50% of radioactivity was eliminated from the organism within 27 hours while following i.v. administration, the elimination took 38 hours. (L.O.)
Berkovits, Alejandro; Aizman, Andrés; Zúñiga, Pamela; Pereira, Jaime; Mezzano, Diego
Thromboembolic disease (TED) is the leading cause of morbidity and mortality worldwide. The hallmark of oral long-term anticoagulant therapy has been the use of vitamin K antagonists, whose anticoagulant effect is exerted inhibiting vitamin K epoxide reductase. Warfarin and acenocoumarol are the most commonly used. In the last five years several new drugs for long term anticoagulation have been developed, which can inhibit single clotting factors with the purpose of improving drug therapeutic range and, ideally, minimizing bleeding risks. This review addresses the state of the art on the clinical use of inhibitors of activated factor X and thrombin.
Sun, Xin E.; Hansen, Bjarne Gram; Hedstrom, Lizbeth
The filamentous fungus Penicillium brevicompactum produces the immunosuppressive drug mycophenolic acid (MPA), which is a potent inhibitor of eukaryotic IMP dehydrogenases (IMPDHs). IMPDH catalyzes the conversion of IMP to XMP via a covalent enzyme intermediate, E-XMP*; MPA inhibits by trapping E...... of resistance is not apparent. Here, we show that, unlike MPA-sensitive IMPDHs, formation of E-XMP* is rate-limiting for both PbIMPDH-A and PbIMPDH-B. Therefore, MPA resistance derives from the failure to accumulate the drug-sensitive intermediate....
Boas, Ulrik; Heegaard, Peter M. H.
and in vivo cytotoxicity, as well as biopermeability, biostability and immunogenicity. The review deals with numerous applications of dendrimers as tools for efficient multivalent presentation of biological ligands in biospecific recognition, inhibition and targeting. Dendrimers may be used as drugs...... for antibacterial and antiviral treatment and have found use as antitumor agents. The review highlights the use of dendrimers as drug or gene delivery devices in e.g. anticancer therapy, and the design of different host-guest binding motifs directed towards medical applications is described. Other specific examples...
Meng, Lingzhong; Li, Jian; Lu, Yi; Sun, Dajin; Tao, Yuan-Xiang; Liu, Renyu; Luo, Jin Jun
There is a petition for tight control of ketamine from the Chinese government to classify ketamine as a Schedule I drug, which is defined as a drug with no currently accepted medical use but a high potential for abuse. However, ketamine has unique properties that can benefit different patient populations. Scholars from the Translational Perioperative and Pain Medicine and the International Chinese Academy of Anesthesiology WeChat groups had an interactive discussion on ketamine, including its current medical applications, future research priorities, and benefits versus risks. The discussion is summarized in this manuscript with some minor edits.
Random drug testing of people being treated for chronic pain has become more common. Physicians may drug test patients on opioid therapy as a result of concerns over prosecution, drug misuse, addiction, and overdose. However, profit motive has remained unexplored. This article suggests profits also drive physician drug-testing behavior and evidence is offered, including an exploration of Medicare reimbursement incentives and kickbacks for drug testing.
Foxall, Gordon Robert; Sigurdsson, Valdimar
Seeking integration of drug consumption research by a theory of memory function and emphasizing drug consumption rather than addiction, Müller & Schumann (M&S) treat drug self-administration as part of a general pattern of consumption. This insight is located within a more comprehensive framework for understanding drug use as consumer behavior that explicates the reinforcement contingencies associated with modes of drug consumption.
Li, S. Kevin; Lizak, Martin J.; Jeong, Eun-Kee
Conventional pharmacokinetic methods for studying ocular drug delivery are invasive and cannot be conveniently applied to humans. The advancement of MRI technology has provided new opportunities in ocular drug-delivery research. MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent. It is a useful technique in pharmacokinetic studies, evaluation of drug-delivery methods, and drug-delivery de...
Hembruff, Stacey L; Laberge, Monique L; Villeneuve, David J; Guo, Baoqing; Veitch, Zachary; Cecchetto, Melanie; Parissenti, Amadeo M
Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters. It remains unclear whether drug resistance in vitro occurs at clinically relevant doses of chemotherapy drugs and whether both the onset and magnitude of drug resistance can be temporally and causally correlated with the enhanced expression and activity of specific drug transporters. To address these issues, MCF-7 cells were selected for survival in increasing concentrations of doxorubicin (MCF-7 DOX-2 ), epirubicin (MCF-7 EPI ), paclitaxel (MCF-7 TAX-2 ), or docetaxel (MCF-7 TXT ). During selection cells were assessed for drug sensitivity, drug uptake, and the expression of various drug transporters. In all cases, resistance was only achieved when selection reached a specific threshold dose, which was well within the clinical range. A reduction in drug uptake was temporally correlated with the acquisition of drug resistance for all cell lines, but further increases in drug resistance at doses above threshold were unrelated to changes in cellular drug uptake. Elevated expression of one or more drug transporters was seen at or above the threshold dose, but the identity, number, and temporal pattern of drug transporter induction varied with the drug used as selection agent. The pan drug transporter inhibitor cyclosporin A was able to partially or completely restore drug accumulation in the drug-resistant cell lines, but had only partial to no effect on drug sensitivity. The inability of cyclosporin A to restore drug sensitivity suggests the presence of additional mechanisms of drug resistance. This study indicates that drug resistance is achieved in breast tumour cells only upon exposure to concentrations of drug at or above a specific selection dose. While changes in drug accumulation and the expression of drug transporters does occur at the threshold dose, the magnitude of
Sulochana, Suresh P; Syed, Muzeeb; Chandrasekar, Devaraj V
of drugs. This review covers several category of drugs such as non-steroidal anti-inflammatory drugs, fluoroquinolones, histamine H2-receptor blockers, macrolides, anti-fungals, anti-diabetics, salicylic acid derivatives, steroidal anti-inflammatory drugs and provides pharmacokinetic data summary along...
Boutroy, M J
Drugs have been in the past and will in the future still be liable to induce apnea in neonates, infants and older children. At these different stages of development, the child may be abnormally vulnerable to respiratory disorders and apnea, and doses of drugs, without any abnormal side effects in adult patients, can be harmful in younger subjects. Drugs responsible for apnea during development are numerous, but more than half of the problems are induced by sedatives and hypnotics, among which phenothiazines, barbiturates, benzodiazepines (included transplacentally acquired) and general anesthetics are a few. Other pharmacological families are apnea inducers in the neonatal period and childhood: analgesics and opioid narcotics, agents acting at the levels of neuromuscular function and autonomic ganglia, and cardiovascular agents. The pathogenesis of these apneas depends on the disturbance of any mechanism responsible for the respiratory activity: medullary centers and brain stem structures, afferent influx to CNS, sleep stages, upper airways, lungs and respiratory muscles. At key stages such as birth and infancy, drugs may emphasize the particular sensitivity of the mechanisms responsible for inducing apnea. This might explain unexpected respiratory disorders during development.
Drugs may be used by athletes for a number of reasons, including performance enhancement. The role of the World Anti-Doping Agency (WADA) is vital to ensure a winning performance has been achieved by fair means. Substances and methods that are included on the WADA Prohibited List are described. The procedures for testing banned substances are…
... of pharmacogenetics with substance dependence and brain imaging, and consider the impact of pharmacogenetics on the biotechnology and pharmaceutical industries. This book deﬁnes the young ﬁeld of pharmacogenetics as it applies to psychotropic drugs and is, therefore, an essential reference for all clinicians and researchers working in this ﬁndings ﬁeld. Bernard ...
statistics show that almost half a million new ... testing for second-line drugs, no international consensus has been reached about .... Given the high background rates of TB and MDR-TB in several countries, regimens are often constructed ...
In this podcast, Dr. Joe Bresee explains the nature of antiviral drugs and how they are used for seasonal flu. Created: 9/29/2010 by National Center for Immunization and Respiratory Diseases (NCIRD). Date Released: 9/29/2010.
Hladik, W.B.; Ponto, J.A.; Stathis, V.J.
Patients seen in the nuclear medicine department have a wide variety of disorders and, consequently, may be receiving any number of therapeutic drugs. For this reason, nuclear medicine professionals should be aware of the potential effects that these pharmacologic agents may have on the bio-distribution of subsequently administered radiopharmaceuticals, commonly referred to as ''drug-radiopharmaceutical interactions.'' Compared with the quantity of literature written about interactions between various therapeutic drugs, the information available on drug-radiopharmaceutical interactions is scarce. However, there has been increasing interest in this subject, particularly during the past five years. Some of the reported interactions are used intentionally to add a new dimension to the nuclear medicine study and increase its diagnostic capabilities, i.e., pharmacologic intervention. These beneficial ''interactions'' are discussed in detail in several other chapters of this book. Other interactions, however, cause changes in the normal distribution of radiopharmaceuticals, which may interfere with the diagnostic utility of various nuclear medicine procedures. The latter group of interactions is the focus of this chapter
Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 12. Crystallography and Drug Design. K Suguna. General Article Volume 19 Issue 12 December 2014 pp 1093-1103. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/019/12/1093-1103. Keywords.
disease. The :most dangerous but least co:m:mon for:m of drug allergy is .... immune response, and allergic reaction occur in only ... mental sensitisation by milk and aerosol.11,19 ... requires cross-linking of the high-affinity specific IgE Fc.
a new attitude to eating. Adjunctive measures aimed at modifying behaviour, such as psychotherapy and group therapy, may help in individual cases. Psychological factors in response to stress would appear to be the basis of some cases of obesity, but the use of psychotropic drugs is limited and for specific indications only.
Luttge, R.; Dietzel, A.
Drug delivery through microneedles is a new form of a pharmaceutical dosage system. While single microneedles have been clinically applied already, the out-of-plane integration of a multitude of microneedles in a pharmaceutical patch is a disruptive technology. To take advantage of micro- and
The effect of drugs such as glucocorticoids and thyroid extract on calcium metabolism is unknown. However, several other medications affect the excretion and intestinal absorption of calcium. A controlled study was carried out to investigate these aspects. Urinary calcium was determined for 3 months during the long-term intake of the antituberculous drug isoniazid (INH) and of the antibiotic tetracycline. The effect of the diuretics furosemide and hydrochlorothiazide, of several aluminum-containing antacids, of thyroid extract and of corticosteroids was also studied. Metabolic balances of calcium, phosphorus, magnesium and zinc were determined, as well as the intestinal absorption of calcium using Ca 47. Plasma levels, urinary and fecal excretions of Ca 47 were determined. All drugs tested increased urinary calcium except for the diuretic hydrochlorothiazide. Regarding the effect of corticosteroids: the intestinal absorption of calcium was unchanged after the short-term use and was very high after long-term use. The studies have shown that several commonly used drugs induce an increase in urinary calcium excretion which may contribute to calcium loss, if this increase persists for prolonged periods of time. Urinary excretions of phosphorus, magnesium and zinc increased in some of the studies
Colice, Gene L
The goal of asthma therapy is to reduce symptoms to the extent that patients can lead active, unlimited lives and to minimize concern about exacerbations. Unfortunately, despite advances in our understanding of the pathophysiology of asthma and the existence of consensus asthma-management guidelines, patients with asthma still suffer considerable morbidity and, on rare occasions, death. Part of the reason for suboptimal asthma control is poor adherence, by both providers and patients, to the recommended asthma regimens and guidelines. However, even under the ideal circumstances of a motivated patient and a knowledgeable physician, the available asthma drugs are not effective in all patients at all times. The market for asthma drugs has been dynamic; numerous new products have recently been approved for marketing by the Food and Drug Administration. Unfortunately, the products recently approved and those likely to enter the market soon mostly are either reformulations or combinations of established molecules. Developing new drugs to treat asthma, particularly with novel anti-inflammatory properties, should be a priority.
is of immense help in developing drugs for specific diseases by targeting molecules ... tions, or selected from a large pool of available libraries and the binding strengths can ... was identified to be caused by a virus named later as the human.
... molecule that contains genetic instructions to make proteins. Delivery of CFTR-encoded mRNA would allow the lung cells to create normally functioning CFTR protein, regardless of an individual’s specific CFTR gene mutation. This drug is delivered via inhalation. Editas This program is ...
Warner, Benjamin P.; McCleskey, T. Mark; Burrell, Anthony K.
X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
Plummer, Nancy; Michael, Nancy, Ed.
This module on drugs used in chronic obstructive pulmonary disease (COPD) is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first.…
Chambliss, William; Scorza, Thomas
Presents two opposing viewpoints concerning the legalization of drugs. States that control efforts are not cost effective and suggests that legalization with efforts at education is a better course of action (W. Chambliss). The opposing argument contends that the cost in human suffering negates any savings in dollars gained through legalization…
... were prescribed to someone else or if your child is already taking other prescription medications. Set rules. Let your teen know that it's not OK to share medications with others — or to take drugs prescribed for others. Emphasize the importance of taking the prescribed dose and talking with ...
Davis, Gregory G
Drug abusers have access to new, more potent compounds that evade existing laws by virtue of their novel chemical structures. These drugs are available for purchase at stores and over the internet. The drugs are not illegal because they are so new that laws have not yet been passed to ban them. These drugs are leading to emergency department visits for cardiovascular, neurologic, and psychiatric complications. Standard drug screens are not designed to detect these new substances. The internet provides access to drugs for substance abusers but also provides physicians speed of access to the habits of substance abusers.
Leroy, Clara; Rigot, Jean-Marc; Leroy, Maryse; Decanter, Christine; Le Mapihan, Kristell; Parent, Anne-Sophie; Le Guillou, Anne-Claire; Yakoub-Agha, Ibrahim; Dharancy, Sébastien; Noel, Christian; Vantyghem, Marie-Christine
Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune diseases, as well as in transplantation. Frequently prescribed in young people, these treatments may have deleterious effects on fertility, pregnancy outcomes and the unborn child. This review aims to summarize the main gonadal side effects of immunosuppressants, to detail the effects on fertility and pregnancy of each class of drug, and to provide recommendations on the management of patients who are seen prior to starting or who are already receiving immunosuppressive treatment, allowing them in due course to bear children. The recommendations for use are established with a rather low level of proof, which needs to be taken into account in the patient management. Methotrexate, mycophenolate, and le- and teri-flunomide, cyclophosphamide, mitoxanthrone are contraindicated if pregnancy is desired due to their teratogenic effects, as well as gonadotoxic effects in the case of cyclophosphamide. Anti-TNF-alpha and mTOR-inhibitors are to be used cautiously if pregnancy is desired, since experience using these drugs is still relatively scarce. Azathioprine, glucocorticoids, mesalazine, anticalcineurins such as cyclosporine and tacrolimus, ß-interferon, glatiramer-acetate and chloroquine can be used during pregnancy, bearing in mind however that side effects may still occur. Experience is limited concerning natalizumab, fingolimod, dimethyl-fumarate and induction treatments. Conclusion: At the time of prescription, patients must be informed of the possible consequences of immunosuppressants on fertility and of the need for contraception. Pregnancy must be planned and the treatment modified if necessary in a pre-conception time period adapted to the half-life of the drug, imperatively in relation with the prescriber of the immunosuppressive drugs.
... more) drugs or between a drug and a food or beverage. Taking a drug while having certain medical conditions ... interaction : A reaction between a drug and a food or beverage. Drug-condition interaction : A reaction that occurs when ...
Bayuse, Tina M.
Published drug information is widely available for terrestrial conditions. However, information on dosing, administration, drug interactions, stability, and side effects is scant as it relates to use in Space Medicine. Multinational crews on board the International Space Station present additional challenges for drug information because medication nomenclature, information available for the drug as well as the intended use for the drug is not standard across countries. This presentation will look at unique needs for drug information and how the information is managed in Space Medicine. A review was conducted of the drug information requests submitted to the Johnson Space Center Pharmacy by Space Medicine practitioners, astronaut crewmembers and researchers. The information requested was defined and cataloged. A list of references used was maintained. The wide range of information was identified. Due to the information needs for the medications in the on-board medical kits, the Drug Monograph Project was created. A standard method for answering specific drug information questions was generated and maintained by the Johnson Space Center Pharmacy. The Drug Monograph Project will be presented. Topic-centered requests, including multinational drug information, drug-induced adverse reactions, and medication events due to the environment will be highlighted. Information management of the drug information will be explained. Future considerations for drug information needs will be outlined.
Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: prevalence, clinical importance and associated factors. SJ Lubinga, E Uwiduhaye ...
Purpose: To identify clinically significant potential drug-drug interactions in cardiac intensive care units of two tertiary care ... hypertension, hyperlipidemia, diabetes or other diseases .... May result in digoxin toxicity (nausea, vomiting, cardiac.
Full Text Available Diazepam is a benzodiazepine derivative with anxyolitic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, antitremor, and amnestic activity. It is metabolized in the liver by the cytochrome P (CYP 450 enzyme system. Diazepam is N-demethylated by CYP3A4 and CYP2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam. N-desmethyl-diazepam and temazepam are both further metabolized to oxazepam. Concomitant intake of inhibitors or inducers of the CYP isozymes involved in the biotransformation of diazepam may alter plasma concentrations of this drug, although this effect is unlikely to be associated with clinically relevant interactions.The goal of this article was to review the current literature on clinically relevant pharmacokinetic drug interactions with diazepam.A search of MEDLINE and EMBASE was conducted for original research and review articles published in English between January 1971. and May 2011. Among the search terms were drug interactions, diazepam, pharmacokinetics, drug metabolism, and cytochrome P450. Only articles published in peer-reviewed journals were included, and meeting abstracts were excluded. The reference lists of relevant articles were hand-searched for additional publications.Diazepam is substantially sorbed by the plastics in flexible containers, volume control set chambers, and tubings of intravenous administration sets. Manufacturers recommend not mixing with any other drug or solution in syringe or solution, although diazepam is compatible in syringe with cimetidine and ranitidine, and in Y-site with cisatracurium, dobutamine, fentanyl, hydromorphone, methadone, morphine, nafcillin, quinidine gluconate, remifentanil, and sufentanil. Diazepam is compatible with: dextrose 5% in water, Ringers injection, Ringers injection lactated and sodium chloride 0.9%. Emulsified diazepam is compatible with Intralipid and Nutralipid.Diazepam has low potential
Aldridge, Judith A; Décary-Hétu, David
Background: In spite of globalizing processes ‘offline’ retail drug markets remain localized and – in recent decades – typically ‘closed’, in which dealers sell primarily to known customers. We characterize drug cryptomarkets as ‘anonymous open’ marketplaces that allow the diffusion of drugs across locales. Where cryptomarket customers make stock-sourcing purchases for offline distribution, the cryptomarket may indirectly serve drug users who are not themselves cryptomarket customers, thereby...
As práticas escolares e a formação cívico-patriótica no ginásio mineiro de Uberlândia, em Minas Gerais, Brasil (1920-1970 - School practices and civic and patriotic education in lower secondary school in Uberlândia, Minas Gerais, Brazil (1920/1970
Giseli Cristina do Vale Gatti, Geraldo Inácio Filho
Full Text Available Resumo Trata-se do exame das práticas escolares efetivadas no Ginásio Mineiro de Uberlândia, em Minas Gerais, Brasil, no período compreendido entre as décadas de 1920 e de 1970. Depreende-se do cotejamento das evidências (manuscritas, impressas, orais e iconográficas com o contexto sócio-histórico da época que: a metodologia de ensino no período era tradicional; a consolidação de uma representação social da qualidade do ensino do antigo Ginásio (com caráter humanístico e com preocupação com a moral, a disciplina e os bons costumes; o entendimento da escola como centro social, esportivo e cultural da cidade, sendo as datas cívicas muito comemoradas. Desse modo, ao conteúdo humanístico, ligado à disseminação de princípios morais aceitos socialmente, somava-se a ênfase no civismo e no patriotismo. Palavras-chave: escola; civismo; patriotismo; currículo; práticas. SCHOOL PRACTICES AND CIVIC AND PATRIOTIC EDUCATION IN LOWER SECONDARY SCHOOL IN UBERLANDIA, MINAS GERAIS, BRAZIL (1920/1970 Abstract This study is an examination of school practices in the Lower Secondary School in Uberlandia, Minas Gerais, Brazil, in the decades from the 1920s to 1970s. Conclusions are drawn from the collating of evidence (manuscript, printed, oral and iconographic with the social historical context of the time in which: the teaching methodology was traditional, consolidation of a social representation of the quality of teaching of the ancient Gymnasium (with a humanistic character and concern with morals, discipline e good habits; the school as the social, sporting and cultural center of the city with the civic dates being highly commemorated. In this way, the emphasis on civic education and patriotism was added to a humanistic content connected with the
Introduction: The risk of drug-drug interactions (DDIs) is high in patients with chronic kidney disease (CKD) necessitating dose adjustments or the avoidance of drug combinations. This study aimed to evaluate DDIs among patients with CKD in the University of Nigeria Teaching Hospital (UNTH), Enugu, South-East Nigeria.
Reports of the use of antiretroviral drugs (ARVs) to produce a highly addictive drug called nyaope or whoonga are of major concern as ARVs are easily accessible in sub-Saharan Africa, including to pregnant women. Use of illicit drugs by pregnant women may result in serious adverse effects in their infants. We have ...
Hostenkamp, G.; Fischer, K. E.; Borch-Johnsen, K.
Objective To analyse the impact of drug safety warnings from the European Medicines Agency (EMA) on drug utilisation and their interaction with information released through national reimbursement bodies. Methods Insurance claims data on anti-diabetic drug prescriptions in primary care in Germany...
Prausnitz, Mark R.; Langer, Robert
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin’s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine. PMID:18997767
Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins. Given the fact that structurally not related compounds cause an identical phenotype pinpoints to common targets or pathways, responsible for executing rhabdomyolysis. A drop in myoplasmic ATP paralleled with sustained elevations in cytosolic Ca2+ concentration represents a common signature of rhabdomyolysis. Interestingly, cardiac tissue is hardly affected or only secondary, as a consequence of imbalance in electrolytes or acid–base equilibrium. This dogma is now impaired by compounds, which show up with combined toxicity in heart and skeletal muscle. In this review, cases of rhabdomyolysis with novel recently approved drugs will be explored for new target mechanisms in the light of previously described pathomechanisms. PMID:22560920
This paper reviews the role of the insula in drug craving. Evidence is presented that drug craving may be a particular instance of the anterior insula's broader role in interoception and subjective feeling states similar, for example, to thirst and hunger. An important role for the insula in craving is supported by evidence of insular activity changing with satiety and with the top-down cognitive modulation of cravings. Cognitive processes involving the insula's role in awareness of one's own behaviour may also contribute to craving insofar as the avoidance of craving might require subjective awareness of the endogenous and exogenous cues that initiate it. Finally, some consideration is given to sex differences and developmental processes in craving.
Baker, Danial E
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433. The September 2017 monograph topics are brigatinib, durvalumab, edaravone, midostaurin, and sarilumab. The MUE is on sarilumab.
Baker, Danial E
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service , contact Wolters Kluwer customer service at 866-397-3433.
Ali, Zaynah K; Baker, Danial E
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service , contact Wolters Kluwer customer service at 866-397-3433.
Baker, Danial E
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service , contact Wolters Kluwer customer service at 866-397-3433. The November 2017 monograph topics are Ertugliflozin, Glecaprevir / pibrentasvir, Neratinib, Sofosbuvir, velpatasvir, voxilaprevir and SQ C1 esterase inhibitor. The MUE is on glecaprevir, pibrentasvir.
Ali, Zaynah K; Baker, Danial E
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service , contact Wolters Kluwer customer service at 866-397-3433.
Kyzar, Evan J; Nichols, Charles D; Gainetdinov, Raul R; Nichols, David E; Kalueff, Allan V
Psychedelic drugs, such as lysergic acid diethylamide (LSD), mescaline, and psilocybin, exert profound effects on brain and behavior. After decades of difficulties in studying these compounds, psychedelics are again being tested as potential treatments for intractable biomedical disorders. Preclinical research of psychedelics complements human neuroimaging studies and pilot clinical trials, suggesting these compounds as promising treatments for addiction, depression, anxiety, and other conditions. However, many questions regarding the mechanisms of action, safety, and efficacy of psychedelics remain. Here, we summarize recent preclinical and clinical data in this field, discuss their pharmacological mechanisms of action, and outline critical areas for future studies of psychedelic drugs, with the goal of maximizing the potential benefits of translational psychedelic biomedicine to patients. Copyright © 2017 Elsevier Ltd. All rights reserved.
Sleep is a vital neurochemical process involving sleep-promoting and arousal centers in the brain. Insomnia is a pervasive disorder characterized by difficulties in initiating or maintaining or non-refreshing (poor quality) sleep and clinically significant daytime distress. Insomnia is more prevalent in women and old age and puts sufferers at significant physical and mental health risks. This review summarizes published data on the current and emerging insomnia drug classes, rationale for development and associated risks/benefits. (Summary of Product Characteristics and Medline search on "hypnotic" or specific drug names and "Insomnia"). GABA(A) receptor modulators facilitate sleep onset and some improve maintenance but increase risk of dependence, memory, cognitive and psychomotor impairments, falls, accidents and mortality. Melatonin receptor agonists improve quality of sleep and/or sleep onset but response may develop over several days. They have more benign safety profiles and are indicated for milder insomnia, longer usage and (prolonged release melatonin) older patients. Histamine H-1 receptor antagonists improve sleep maintenance but their effects on cognition, memory and falls remain to be demonstrated. Late-stage pipeline orexin OX1/OX2 and serotonin 5HT2A receptor antagonists may hold the potential to address several unmet needs in insomnia pharmacotherapy but safety issues cast some doubts over their future. Current and new insomnia drugs in the pipeline target different sleep regulating mechanisms and symptoms and have different tolerability profiles. Drug selection would ideally be based on improvement in the quality of patients' sleep, overall quality of life and functional status weighed against risk to the individual and public health.
Mustonen, Pirjo; Puurunen, Marja
Platelet inhibitors and anticoagulants are called antithrombotic drugs. New platelet inhibitors prasugrel and ticagrelor are more effective than the traditional clopidogrel, but their use is also accompanied by more frequent bleeding complications. Varfarin has gained true competitors; new oral anticoagulants include dabigatran, rivaroxaban and apixaban. New anticoagulants are easier to use but clearly more expensive. The use of new anticoagulants is also accompanied by several potential problems that the clinician should be aware of.
Candida albicans] A G1L (590 aa) Flag VV(WR) 30/ENDIDEILGIAHLLEHLLISF/50 107/HIKELENEYYFRNEVFH/123 H41A 30/ENDIDEILGIAALLEHLLISF/50 107...RSV) (Table 1). Additional antiviral drug examples include the use of interferon for human papilloma virus ( HPV ) [Cantell, 1995]. Antivirals are most...low oral bioavailability, and quick elimination from plasma [Ghosn et al., 2004; Hostetler et al., 1994; Kempf et al., 1991; Matsumoto et al., 2001
Sadakierska-Chudy, Anna; Frankowska, Małgorzata; Filip, Małgorzata
Being the center of energy production in eukaryotic cells, mitochondria are also crucial for various cellular processes including intracellular Ca(2+) signaling and generation of reactive oxygen species (ROS). Mitochondria contain their own circular DNA which encodes not only proteins, transfer RNA and ribosomal RNAs but also non-coding RNAs. The most recent line of evidence indicates the presence of 5-methylcytosine and 5-hydroxymethylcytosine in mitochondrial DNA (mtDNA); thus, the level of gene expression - in a way similar to nuclear DNA - can be regulated by direct epigenetic modifications. Up to now, very little data shows the possibility of epigenetic regulation of mtDNA. Mitochondria and mtDNA are particularly important in the nervous system and may participate in the initiation of drug addiction. In fact, some addictive drugs enhance ROS production and generate oxidative stress that in turn alters mitochondrial and nuclear gene expression. This review summarizes recent findings on mitochondrial function, mtDNA copy number and epigenetics in drug addiction. Copyright © 2014 Elsevier Inc. All rights reserved.
Falisi, Giovanni; Rastelli, Claudio; Panti, Fabrizio; Maglione, Horacio; Quezada Arcega, Raul
Sleep and awake bruxism is defined as 'a parafunctional activity including clenching, bracing, gnashing, and grinding of the teeth'. Some evidence suggests that bruxism may be caused by, or associated with, alterations in the CNS neurotransmission. Several classes of psychotropic drugs interfering with CNS activity may potentially contribute to bruxism. Thus, the purpose of this study was to examine relevant peer-reviewed papers to identify and describe the various classes of psychotropic substances that may cause, exacerbate or reduce bruxism as the result of their pharmacological action in CNS neurons. A literature search from 1980 to the present was performed using PubMed database. The term 'bruxism' was used in association with 'psychotropic', 'dopamine (DA)', 'serotonin', 'histamine', 'antipsychotics', 'antidepressants', 'antihistaminergics' and 'stimulants'. Studies on the effects of DA agonists (Levo-DOPA, psychostimulants) and antagonists (antipsychotics) identified a central role of DA in the pathogenesis of pharmacologically induced bruxism. Important information from studies on drugs acting on serotonin neurotransmission (antidepressants) was recognized. Other mechanisms involving different neurotransmitters are emerging. This is the case of antihistaminergic drugs which may induce bruxism as a consequence of their disinhibitory effect on the serotonergic system.
Full Text Available ... and SUDs in LGBT Populations Treatment Trends & Statistics Women and Drugs Publications Search Publications Orderable DrugFacts Research Reports Mind Over Matter Science of Addiction Funding Funding Opportunities Clinical Research Post- ...
Full Text Available ... she went to a party and under the influence of drugs and alcohol engaged in risky sexual ... the message to young people and to parents, teachers, and the media about the link between drug ...
Full Text Available ... Drugs and HIV Learn the Link - Drugs and HIV Email Facebook Twitter 2005 –Ongoing Behaviors associated with ... Send the Message . Get the Facts What are HIV and AIDS? HIV (human immunodeficiency virus) is the ...
The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.
Full Text Available ... HIV Learn the Link - Drugs and HIV ... Drugs can change the way the brain works, disrupting the parts of the brain that people use to weigh risks and benefits when making decisions. ...
U.S. Department of Health & Human Services — The Drug Establishments Current Registration Site (DECRS) is a database of current information submitted by drug firms to register establishments (facilities) which...
Christopher J. Ruhm
Full Text Available Death certificate data from the Multiple Cause of Death (MCOD files were analyzed to better understand the drug categories most responsible for the increase in fatal overdoses occurring between 1999 and 2014. Statistical adjustment methods were used to account for the understatement in reported drug involvement occurring because death certificates frequently do not specify which drugs were involved in the deaths. The frequency of combination drug use introduced additional uncertainty and so a distinction was made between any versus exclusive drug involvement. Many results were sensitive to the starting and ending years chosen for examination. Opioid analgesics played a major role in the increased drug deaths for analysis windows starting in 1999 but other drugs, particularly heroin, became more significant for recent time periods. Combination drug use was important for all time periods and needs to be accounted for when designing policies to slow or reverse the increase in overdose deaths.
The kidney receives a rich blood flow of 25% of resting cardiac output ... Drugs can cause acute renal failure by causing pre-renal, intrinsic or .... tubular epithelial cells causing cell swelling ... the dose as required or prescribe alternative drugs.
Full Text Available ... Plan Search Share ... Behaviors associated with drug misuse are among the main factors in the spread of HIV infection in the United States. Drugs can change the way the brain works, ...
Full Text Available ... depict the devastating consequences of compromised judgment and critical thinking that can result from drug use. Young ... HIV epidemic. As we learn more about the critical connection between drug misuse and HIV/AIDS and ...
As the patents on widely used biological drugs to treat cancer expire, biosimilar drugs are being developed for the treatment of patients with cancer. You can learn how biosimilars may expand treatment options in this Cancer Currents blog post.
Impotence caused by medications; Drug-induced erectile dysfunction; Prescription medicines and impotence ... Many medicines and recreational drugs can affect a man's sexual arousal and sexual performance. What causes impotence in one ...