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Sample records for partialis continua epc

  1. Acute Porphyria Presenting as Epilepsia Partialis Continua

    Directory of Open Access Journals (Sweden)

    Thi Phuoc Yen Tran

    2013-06-01

    Full Text Available Purpose: The porphyrias are a defect in the biosynthesis of heme which can be associated with different neurological symptoms during acute attacks such as peripheral neuropathy, mental disturbance and seizures. So far, there have only been a few case reports of status epilepticus, none of which were of epilepsia partialis continua (EPC. We present here two cases of hereditary coproporphyria (HCP manifesting EPC as part of the clinical presentation. Method: The patients' medical charts, EEG and imaging studies were carefully reviewed. Results: Case 1 is a 49-year-old male who first presented a tonic-clonic seizure. Case 2 is a 30-year-old male who came to the emergency room for a convulsive status epilepticus. Both evolved to EPC over the next days. EPC persisted despite several antiepileptic drug trials. Diagnosis of HCP was confirmed by a high level of urine, fecal and serum porphyrins in both cases and by genetic testing in one. Over the last 3 years, the first patient has continued to present non-disabling EPC and has had four tonic-clonic seizures associated with alcohol consumption. The second patient died from brain edema one month and half after admission. Conclusion: Acute porphyrias should be included in the differential diagnosis of new onset status epilepticus, including EPC. Their recognition is important as it modifies significantly patient management, since many anticonvulsants are porphyrogenic.

  2. Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua: a European survey and analysis of 65 cases

    DEFF Research Database (Denmark)

    Mameniskiene, Ruta; Bast, Thomas; Bentes, Carla

    2011-01-01

    To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation.......To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation....

  3. Menkes Disease Presenting with Epilepsia Partialis Continua

    Directory of Open Access Journals (Sweden)

    Tamer Rizk

    2014-01-01

    Full Text Available Aim. We aim to describe a female patient with Menkes disease who presented with epilepsia partialis continua. Case Presentation. Seventeen-months-old Saudi infant was presented with repetitive seizures and was diagnosed to have epilepsia partialis continua. Discussion. Menkes disease (OMIM: 309400 is considered a rare, X-linked recessive neurodegenerative disorder resulting from a mutation in the gene coding for the copper transporting ATPase (ATP7A. Affected individuals usually present with kinky hair, skeletal changes, prolonged jaundice, hypothermia, developmental regression, decreased tone, spasticity, weakness, and therapy resistant seizures. Conclusion. Raising awareness of abnormal presentation of this rare disease may help in the control of seizures through subcutaneous copper supplementation.

  4. Epilepsia partialis continua Kozevnikov. Correlation of cranial computertomography and EEG-findings

    Energy Technology Data Exchange (ETDEWEB)

    Lipinski, C.G.

    1982-10-01

    Two children with onset of epilepsia partialis continua (Epc) in the age of 8 years are described. EEG-findings and cranial computertomography are compared. Were as the CAT is demonstrating the underlaying morphological lesion of Epc, the EEG is showing the epileptic phenomena. Both, anatomic lesion and electronencephalographic focus can show quite different localisations. Despite this findings, to establish the diagnosis Epc, in our cases the computertomographic proof of a cortical and subcortical lesion seems to be important.

  5. Epilepsia partialis continua Kozevnikov. Correlation of cranial computertomography and EEG-findings

    International Nuclear Information System (INIS)

    Lipinski, C.G.

    1982-01-01

    Two children with onset of epilepsia partialis continua (Epc) in the age of 8 years are described. EEG-findings and cranial computertomography are compared. Were as the CAT is demonstrating the underlaying morphological lesion of Epc, the EEG is showing the epileptic phenomena. Both, anatomic lesion and electronencephalographic focus can show quite different localisations. Despite this findings, to establish the diagnosis Epc, in our cases the computertomographic proof of a cortical and subcortical lesion seems to be important. (orig.) [de

  6. Epilepsia partialis continua responsive to neocortical electrical stimulation.

    Science.gov (United States)

    Valentin, Antonio; Ughratdar, Ismail; Cheserem, Beverly; Morris, Robert; Selway, Richard; Alarcon, Gonzalo

    2015-08-01

    Epilepsia partialis continua (EPC), defined as a syndrome of continuous focal jerking, is a rare form of focal status epilepticus that usually affects a distal limb, and when prolonged, can produce long-lasting deficits in limb function. Substantial electrophysiologic evidence links the origin of EPC to the motor cortex; thus surgical resection carries the risk of significant handicap. We present two patients with focal, drug-resistant EPC, who were admitted for intracranial video-electroencephalography monitoring to elucidate the location of the epileptogenic focus and identification of eloquent motor cortex with functional mapping. In both cases, the focus resided at or near eloquent motor cortex and therefore precluded resective surgery. Chronic cortical stimulation delivered through subdural strips at the seizure focus (continuous stimulation at 60-130 Hz, 2-3 mA) resulted in >90% reduction in seizures and abolition of the EPC after a follow-up of 22 months in both patients. Following permanent implantation of cortical stimulators, no adverse effects were noted. EPC restarted when intensity was reduced or batteries depleted. Battery replacement restored previous improvement. This two-case report opens up avenues for the treatment of this debilitating condition. Wiley Periodicals, Inc. © 2015 International League Against Epilepsy.

  7. Steroid-Responsive Epilepsia Partialis Continua with Anti-Thyroid Antibodies: A Spectrum of Hashimoto's Encephalopathy

    Directory of Open Access Journals (Sweden)

    Hiroki Masuda

    2014-05-01

    Full Text Available Background: When a neuropsychiatric symptom due to encephalopathy develops in a patient with anti-thyroid antibodies, especially when the symptom is steroid-responsive, Hashimoto's encephalopathy (HE needs to be included in the differential diagnosis of the patient. Although HE is an elusive disease, it is thought to cause various clinical presentations including seizures, myoclonus, and epilepsia partialis continua (EPC. Case Report: We present the case of a 33-year-old Japanese woman who acutely developed EPC in the right hand as an isolated manifestation. A thyroid ultrasound showed an enlarged hypoechogenic gland, and a thyroid status assessment showed euthyroid with high titers of thyroid antibodies. A brain MRI revealed a nodular lesion in the left precentral gyrus. Corticosteroid treatment resulted in a cessation of the symptom. Conclusions: A precentral nodular lesion can be responsible for steroid-responsive EPC in a patient with anti-thyroid antibodies and may be caused by HE. The serial MRI findings of our case suggest the presence of primary demyelination, with ischemia possibly due to vasculitis around the demyelinating lesion.

  8. Epilepsia partialis continua present with shoulder joint-trunk-hip joint rhythmic clonic seizure: a case report

    Directory of Open Access Journals (Sweden)

    Lv YD

    2016-09-01

    Full Text Available Yudan Lv, Zan Wang, Fengna Chu, Chang Liu, Hongmei Meng Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, ChangChun, People’s Republic of China Abstract: Epilepsia partialis continua (EPC is a particular type of epilepsy which is distinguished from “common epilepsy” by its characteristic semiological features. However, unusual manifestations should be described in order to give awareness at clinical diagnosis. In this case report we describe a rare EPC case not previously reported, in which left shoulder joint-trunk-hip joint jerk was present for 1 week. Abnormal electroencephalogram and cerebrospinal fluid results supported a diagnosis of viral encephalitis. Antiepileptic treatment seemed effective. Our report emphasizes that a detailed functional anatomical analysis and synchronized electroencephalogram discharge should be done to avoid misdiagnosis in patients with synchronic shoulder-trunk-hip jerk symptoms. Keywords: EPC, shoulder-trunk-hip, EEG, clonic seizure, virus encephalitis

  9. A unique case of nontraumatic femoral neck fracture following epilepsia partialis continua

    Directory of Open Access Journals (Sweden)

    Karl O. Nakken

    2015-01-01

    Full Text Available People with epilepsy are more accident prone than the non-epilepsy population. Bone fractures are most often due to seizure-related falls. However, seizures themselves, in particular generalized tonic-clonic seizures, may also cause fractures, e.g. of the thoracic spine. Here, I present a man who developed focal epilepsy following a subarachnoidal hemorrhage. During a focal motor seizure with left-sided convulsions and preserved consciousness that lasted 2 hrs, he sustained a femoral neck fracture. In persons with low mineral density, as in this case, contractions associated with simple focal motor seizures may be sufficient to give rise to such a severe complication.

  10. Electrodynamics of continua

    CERN Document Server

    Eringen, A C

    1990-01-01

    The electrodynamics of continua is a branch ofthe physical sciences concerned with the interaction of electromagnetic fields with deformable bodies. De­ formable bodies are considered to be continua endowed with continuous distributions of mass and charge. The theory of electromagnetic continua is concerned with the determination of deformations, motions, stress, and elec­ tromagnetic fields developed in bodies upon the applications of external loads. External loads may be of mechanical origin (e.g., forces, couples, constraints placed on the surface of the body, and initial and boundary conditions arising from thermal and other changes) and/or electromagnetic origin (e.g., electric, magnetic, and current fields). Because bodies of different constitutions respond to external stimuli in a different way, it is imperative to characterize properly the response functions relevant to a given class of continua. This is done by means of the constitutive theory. For example, an elastic dielectric responds to electro...

  11. Continua or Chimera?

    Science.gov (United States)

    Booth, Tony

    1994-01-01

    This article looks at two concepts in the British 1993 draft Code of Practice concerning students with special needs: the concepts of a "continuum of needs" and a "continuum of provision." Issues involved in connecting the two continua are addressed, including whether service delivery decisions should be based on severity of…

  12. Topics on continua

    CERN Document Server

    Macias, Sergio

    2005-01-01

    Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

  13. BEX Mejora continua framework

    OpenAIRE

    García Ramírez, David

    2014-01-01

    Memoria de la implementación de un software que permite la gestión y control de todo el framework que requiere gestionar el departamento de mejora continua (BEX Business Excelence). Memòria de la implementació d'un programari que permet la gestió i control de tot el framework que requereix gestionar el departament de millora contínua (BEX Business Excelence). Master thesis for the Free Software program.

  14. Event-Driven Process Chains (EPC)

    Science.gov (United States)

    Mendling, Jan

    This chapter provides a comprehensive overview of Event-driven Process Chains (EPCs) and introduces a novel definition of EPC semantics. EPCs became popular in the 1990s as a conceptual business process modeling language in the context of reference modeling. Reference modeling refers to the documentation of generic business operations in a model such as service processes in the telecommunications sector, for example. It is claimed that reference models can be reused and adapted as best-practice recommendations in individual companies (see [230, 168, 229, 131, 400, 401, 446, 127, 362, 126]). The roots of reference modeling can be traced back to the Kölner Integrationsmodell (KIM) [146, 147] that was developed in the 1960s and 1970s. In the 1990s, the Institute of Information Systems (IWi) in Saarbrücken worked on a project with SAP to define a suitable business process modeling language to document the processes of the SAP R/3 enterprise resource planning system. There were two results from this joint effort: the definition of EPCs [210] and the documentation of the SAP system in the SAP Reference Model (see [92, 211]). The extensive database of this reference model contains almost 10,000 sub-models: 604 of them non-trivial EPC business process models. The SAP Reference model had a huge impact with several researchers referring to it in their publications (see [473, 235, 127, 362, 281, 427, 415]) as well as motivating the creation of EPC reference models in further domains including computer integrated manufacturing [377, 379], logistics [229] or retail [52]. The wide-spread application of EPCs in business process modeling theory and practice is supported by their coverage in seminal text books for business process management and information systems in general (see [378, 380, 49, 384, 167, 240]). EPCs are frequently used in practice due to a high user acceptance [376] and extensive tool support. Some examples of tools that support EPCs are ARIS Toolset by IDS

  15. Continua with microstructure

    CERN Document Server

    Capriz, Gianfranco

    1989-01-01

    This book proposes a new general setting for theories of bodies with microstructure when they are described within the scheme of the con­ tinuum: besides the usual fields of classical thermomechanics (dis­ placement, stress, temperature, etc.) some new fields enter the picture (order parameters, microstress, etc.). The book can be used in a semester course for students who have already followed lectures on the classical theory of continua and is intended as an introduction to special topics: materials with voids, liquid crystals, meromorphic con­ tinua. In fact, the content is essentially that of a series of lectures given in 1986 at the Scuola Estiva di Fisica Matematica in Ravello (Italy). I would like to thank the Scientific Committee of the Gruppo di Fisica Matematica of the Italian National Council of Research (CNR) for the invitation to teach in the School. I also thank the Committee for Mathematics of CNR and the National Science Foundation: they have supported my research over many years and given ...

  16. Electrodynamics of continua

    CERN Document Server

    Eringen, A C

    1990-01-01

    This is the second volume of a two-volume set presenting a unified approach to the electrodynamics of continua, based on the principles of contemporary continuum of physics. The first volume was devoted mainly to the development of the theory and applications to deformable solid media. This volume extends the developments of the first volume to richer and newer grounds. It contains discussions on fluid media, magnetohydrodynamics, eletrohydrodynamics and media with more complicated structures. With the discussion, in the last two chapters, of memory-dependent materials and non-local E-M theory, the authors account for the nonlocal effects arising from motions and fields of material points at past times and at spatially distant points. This discussion is included here to stimulate further research in these important fields, which are presently in development stages. The second volume is self-contained and can be studied without the help of volume I. A section summarizing the constitutive equations and the unde...

  17. Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

    Science.gov (United States)

    Huang, Xu; Spencer, Gary J; Lynch, James T; Ciceri, Filippo; Somerville, Tim D D; Somervaille, Tim C P

    2013-01-01

    Through a targeted knockdown (KD) screen of chromatin regulatory genes we identified the EP400 complex components EPC1 and EPC2 as critical oncogenic co-factors in acute myeloid leukemia (AML). EPC1 and EPC2 were required for the clonogenic potential of human AML cells of multiple molecular subtypes. Focusing on MLL-mutated AML as an exemplar, Epc1 or Epc2 KD induced apoptosis of murine MLL-AF9 AML cells and abolished leukemia stem cell potential. By contrast, normal hematopoietic stem and progenitor cells (HSPC) were spared. Similar selectivity was observed for human primary AML cells versus normal CD34+ HSPC. In keeping with these distinct functional consequences, Epc1 or Epc2 KD induced divergent transcriptional consequences in murine MLL-AF9 granulocyte-macrophage progenitor-like (GMP) cells versus normal GMP, with a signature of increased MYC activity in leukemic but not normal cells. This was caused by accumulation of MYC protein and was also observed following KD of other EP400 complex genes. Pharmacological inhibition of MYC:MAX dimerization, or concomitant MYC KD, reduced apoptosis following EPC1 KD, linking the accumulation of MYC to cell death. Therefore EPC1 and EPC2 are components of a complex which directly or indirectly serves to prevent MYC accumulation and AML cell apoptosis, thus sustaining oncogenic potential. PMID:24166297

  18. Alliance contract for offshore EPC projects; Acordos de alianca em projetos EPC para instalacoes offshore

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Sergio Gil Sias; Barbosa, Fernando Sampaio [Odebrecht S.A. (Brazil)

    2004-07-01

    This paper has the objective of divulgation of the Alliance Agreements concepts in Brazil and to promote its practice amongst organizations with complimentary competencies for the execution of EPC offshore projects. These alliances were first adopted in the 80's as part of the outsourcing process in the industry in general and were adapted to suit EPC offshore projects on the North Sea in the 90's, to render feasible some projects that presented high level of prices and risks. The contractual modality of Alliance Agreements is characterized by an integrated project team composed by the best professionals of the client and the contractor. This team is responsible for the engineering, planning, estimation and risk analysis, matching both client's and contractor's viewpoints and needs, focusing on constructability, suitability for the purpose and cost effectiveness, aiming at having a project realized cost closer to the feasibility studies and creating a 'Win Win' type relationship for all partners involved. (author)

  19. Hereditary separability in Hausdorff continua

    Directory of Open Access Journals (Sweden)

    D. Daniel

    2012-04-01

    Full Text Available We consider those Hausdorff continua S such that each separable subspace of S is hereditarily separable. Due to results of Ostaszewski and Rudin, respectively, all monotonically normal spaces and therefore all continuous Hausdorff images of ordered compacta also have this property. Our study focuses on the structure of such spaces that also possess one of various rim properties, with emphasis given to rim-separability. In so doing we obtain analogues of results of M. Tuncali and I. Loncar, respectively.

  20. PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years' experience at St John's Institute of Dermatology

    International Nuclear Information System (INIS)

    Taylor, C.R.; Hawk, J.L.M.

    1995-01-01

    Our 10-year experience with PUVA treatment for alopecia areata, partialis, totalis and universalis was retrospectively reviewed using charts and follow-up questionnaires for 70 patients at St John's Institute of Dermatology. In all cases, several previous therapies were judged to be unsatisfactory prior to starting PUVA, and many cases were already deemed clinically refractory prior to referral for PUVA. If cases of vellus hair growth are excluded, and those who lost their PUVA-induced regrowth rapidly on follow-up, the effective success rate was at best 6.3% for alopecia areata partialis, 12.5% for alopecia areata totalis and 13.3% for alopecia areata universalis. We affirm that PUVA is generally not an effective treatment for alopecia areata. (Author)

  1. Surviving and prospering in a changing EPC business

    International Nuclear Information System (INIS)

    Walls, D.; Blazewicz, S.; Rao, N.; Little, A.D.

    1998-01-01

    Countries worldwide continue to privatize national utilities and attract foreign investment to meet growing demand for power. As a result, the global power marketplace has become highly complex, competitive, and volatile. The changes that are occurring in the electric utility industry around the world are having a dramatic impact on the way new power and T and D projects are engineered, procured, and constructed (EPC). The power EPC business faces pressures of competition and price reductions. Deregulation uncertainties and slow demand growth in the west have caused many domestic EPC firms to look internationally for new opportunities. They face many challenges, most of which relate to dealing with a much higher level of risk than they had previously been exposed to. This paper discusses some of the critical issues EPC companies are facing worldwide, how leading companies are responding to these challenges, and which strategies are likely to allow EPC companies to prosper and sustain growth in the future. Some attractive future market opportunities are highlighted. This paper concludes that EPC firms will have to develop capabilities in certain key markets, and simultaneously operate globally. EPC firms will have to develop clearer strategies to remain profitable. Either they develop scale globally through consolidation and target aggressive market shares, or develop specialized niches, especially in the technology service areas. EPCs can continue to sustain growth by leveraging in other areas of the power industry what they do best: providing technical services and building infrastructure. EPC firms can capitalize on the growing need for system-level planning and design in fuel, power, and transmission and distribution, or target higher-growth opportunities in high-value market segments such as repowering, cogeneration, and environmental systems

  2. Finite elements of nonlinear continua

    CERN Document Server

    Oden, John Tinsley

    1972-01-01

    Geared toward undergraduate and graduate students, this text extends applications of the finite element method from linear problems in elastic structures to a broad class of practical, nonlinear problems in continuum mechanics. It treats both theory and applications from a general and unifying point of view.The text reviews the thermomechanical principles of continuous media and the properties of the finite element method, and then brings them together to produce discrete physical models of nonlinear continua. The mathematical properties of these models are analyzed, along with the numerical s

  3. Electromagnetic fields in fractal continua

    Energy Technology Data Exchange (ETDEWEB)

    Balankin, Alexander S., E-mail: abalankin@ipn.mx [Grupo “Mecánica Fractal”, Instituto Politécnico Nacional, México D.F., 07738 Mexico (Mexico); Mena, Baltasar [Instituto de Ingeniería, Universidad Nacional Autónoma de México, México D.F. (Mexico); Patiño, Julián [Grupo “Mecánica Fractal”, Instituto Politécnico Nacional, México D.F., 07738 Mexico (Mexico); Morales, Daniel [Instituto Mexicano del Petróleo, México D.F., 07730 Mexico (Mexico)

    2013-04-01

    Fractal continuum electrodynamics is developed on the basis of a model of three-dimensional continuum Φ{sub D}{sup 3}⊂E{sup 3} with a fractal metric. The generalized forms of Maxwell equations are derived employing the local fractional vector calculus related to the Hausdorff derivative. The difference between the fractal continuum electrodynamics based on the fractal metric of continua with Euclidean topology and the electrodynamics in fractional space F{sup α} accounting the fractal topology of continuum with the Euclidean metric is outlined. Some electromagnetic phenomena in fractal media associated with their fractal time and space metrics are discussed.

  4. Alliance contract for offshore EPC projects; Acordos de alianca em projetos EPC para instalacoes offshore

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Sergio Gil Sias; Barbosa, Fernando Sampaio [Odebrecht S.A. (Brazil)

    2004-07-01

    This paper has the objective of divulgation of the Alliance Agreements concepts in Brazil and to promote its practice amongst organizations with complimentary competencies for the execution of EPC offshore projects. These alliances were first adopted in the 80's as part of the outsourcing process in the industry in general and were adapted to suit EPC offshore projects on the North Sea in the 90's, to render feasible some projects that presented high level of prices and risks. The contractual modality of Alliance Agreements is characterized by an integrated project team composed by the best professionals of the client and the contractor. This team is responsible for the engineering, planning, estimation and risk analysis, matching both client's and contractor's viewpoints and needs, focusing on constructability, suitability for the purpose and cost effectiveness, aiming at having a project realized cost closer to the feasibility studies and creating a 'Win Win' type relationship for all partners involved. (author)

  5. EPC projects for EPR Flamanville 3 NPP

    International Nuclear Information System (INIS)

    Diaz, J.I.; Polo, J.; Aymerich, E.; Cubian, B.

    2010-01-01

    IBERDROLA Ingenieria y Construccion is carrying out a handful of activities in the EPR Flamanville 3 -FA3 NPP- context since 2007 matching oriented to position the company in the emerging marketplace of new nuclear power plants Generation III+, whose expectation for the next years is highly promising. IBERDROLA Ingenieria y Construccion leads 5 EPC -Engineering, Procurement and Commissioning- projects for FA3 NPP from the Nuclear Island till Sea Water Pumping Station as follows: - Design, procurement. fabrication, installation and testing of 21 shell and tubes heat-exchangers for the nuclear island. 12 out of these 17 HXs are conventional and will be designed according to ASME BPV code Section VIII and have to comply with PED 97/23/CE and ESPN. The remaining 5 HXs are nuclear and will be designed according to ASME BPV code Section III and have also to comply with PED and ESPN. - Design, procurement, fabrication and assembly of 9 demineralizers for different plant systems. Three of these Important To Safety (IPS) equipments have been manufactured according with ASME VIII codes and six of them with EN 13445 code plus additional requirements to comply with PED and final client requirements for nuclear island. - Design, fabrication and installation of qualified travelling water screening filters. The equipments furnished will be two nuclear safety qualified filters and associated equipment (cleaning water system and control system). Additionally some auxiliary devices such as grids, automatic trash rakes and stop gates are included in the contract. - Engineering, procurement, fabrication, erection and commissioning for the condensate treatment plant. This system includes a demineralizer tank, 5 filters, reactive injection mixer, pneumatic and manual valves, piping and instrumentation and control systems. - Engineering, procurement erection and commissioning for the electro-chlorination plant to protect the IPS piping for Condensate Water System for FA3. This system

  6. EPC projects for EPR Flamanville 3 NPP

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, J.I.; Polo, J.; Aymerich, E.; Cubian, B. [Nuclear Generation Department, Iberdrola Ingenieria y Construccion, Avda. Manoteras 20, 28050 Madrid (Spain)

    2010-07-01

    IBERDROLA Ingenieria y Construccion is carrying out a handful of activities in the EPR Flamanville 3 -FA3 NPP- context since 2007 matching oriented to position the company in the emerging marketplace of new nuclear power plants Generation III+, whose expectation for the next years is highly promising. IBERDROLA Ingenieria y Construccion leads 5 EPC -Engineering, Procurement and Commissioning- projects for FA3 NPP from the Nuclear Island till Sea Water Pumping Station as follows: - Design, procurement. fabrication, installation and testing of 21 shell and tubes heat-exchangers for the nuclear island. 12 out of these 17 HXs are conventional and will be designed according to ASME BPV code Section VIII and have to comply with PED 97/23/CE and ESPN. The remaining 5 HXs are nuclear and will be designed according to ASME BPV code Section III and have also to comply with PED and ESPN. - Design, procurement, fabrication and assembly of 9 demineralizers for different plant systems. Three of these Important To Safety (IPS) equipments have been manufactured according with ASME VIII codes and six of them with EN 13445 code plus additional requirements to comply with PED and final client requirements for nuclear island. - Design, fabrication and installation of qualified travelling water screening filters. The equipments furnished will be two nuclear safety qualified filters and associated equipment (cleaning water system and control system). Additionally some auxiliary devices such as grids, automatic trash rakes and stop gates are included in the contract. - Engineering, procurement, fabrication, erection and commissioning for the condensate treatment plant. This system includes a demineralizer tank, 5 filters, reactive injection mixer, pneumatic and manual valves, piping and instrumentation and control systems. - Engineering, procurement erection and commissioning for the electro-chlorination plant to protect the IPS piping for Condensate Water System for FA3. This system

  7. Raise the management level of EPC contracting in six aspects

    International Nuclear Information System (INIS)

    Wang Baowei; Feng Shoujia

    2010-01-01

    Nuclear power construction develops rapidly today and EPC contracting for nuclear power projects, as a strategic decision of CNNC, has become a tendency. The target of engineering management can be smoothly realized or achieved by doing a good job in the following six aspects: effective communication between divisions of project department, high-degree consistency of managerial concepts for project management staff, clear objective for different divisions in the project department, presence of rules to be observed in construction management work, avoidance of human-initiated errors in the project, and clear distinction of management control concept. It is hoped that, through exchange and practice, management procedures and consciousness for EPC contracting can be further standardized and thus the level of management for EPC contracting will be raised finally. (authors)

  8. Raise the management level of EPC contracting in six aspects

    International Nuclear Information System (INIS)

    Wang Baowei; Feng Shoujia

    2010-01-01

    Nuclear power construction develops rapidly today and EPC contracting for nuclear power projects, as a strategic decision of CNNC, has become a tendency. The target of engineering management can be smoothly realized or achieved by doing a good job in the following six aspects:effective communication between divisions of project department, high-degree consistency of managerial concepts for project management staff, clear objective for different divisions in the project department, presence of rules to be observed in construction management work, avoidance of human-initiated errors in the project, and clear distinction of management control concept. It is hoped that, through exchange and practice, management procedures and consciousness for EPC contracting can be further standardized and thus the level of management for EPC contracting will be raised finally. (authors)

  9. Engineer, procure, construct (EPC) for nuclear projects in OPG

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, M. [Ontario Power Generation, Toronto, Ontario (Canada)

    2011-07-01

    OPG is exploring the use of EPC contracts for Nuclear Plant Design Modifications. Although OPG has used EPC outside of the nuclear island, this new initiative will begin to use EPC inside the plant, including upgrades to existing stations and mid-life refurbishment of Darlington. Benchmarking has shown that apart from new build, nuclear utilities rarely use this method inside the plant so OPG is using a step-by-step approach starting with projects with low complexity and low plant impact. The expected benefits are reduced interfaces and a simplified accountability model leading to schedule and cost improvements and lower rework. Design packages that incorporate construction input before issue will be a significant improvement. OPG's early challenges in moving to EPC include clearly defining roles, responsibilities and interfaces between the vendors and OPG, and modifying governance to match the new model. OPG intends to oversee the work while holding the vendor accountable for needs skill development on both sides. Vendors are expected to establish an engaged organization with complete knowledge of plant conditions, processes and streamlined methods to gain operations input. Vendors are also expected to identify and fix any quality issues before the modifications are commissioned and to have an in-house corrective action program to continuously improve. Vendors' early challenges include presenting one face to OPG rather than a collection of joint venture partners. This presentation describes OPG's plans and early feedback on this exciting new initiative.

  10. Engineer, procure, construct (EPC) for nuclear projects in OPG

    International Nuclear Information System (INIS)

    Elliott, M.

    2011-01-01

    OPG is exploring the use of EPC contracts for Nuclear Plant Design Modifications. Although OPG has used EPC outside of the nuclear island, this new initiative will begin to use EPC inside the plant, including upgrades to existing stations and mid-life refurbishment of Darlington. Benchmarking has shown that apart from new build, nuclear utilities rarely use this method inside the plant so OPG is using a step-by-step approach starting with projects with low complexity and low plant impact. The expected benefits are reduced interfaces and a simplified accountability model leading to schedule and cost improvements and lower rework. Design packages that incorporate construction input before issue will be a significant improvement. OPG's early challenges in moving to EPC include clearly defining roles, responsibilities and interfaces between the vendors and OPG, and modifying governance to match the new model. OPG intends to oversee the work while holding the vendor accountable for needs skill development on both sides. Vendors are expected to establish an engaged organization with complete knowledge of plant conditions, processes and streamlined methods to gain operations input. Vendors are also expected to identify and fix any quality issues before the modifications are commissioned and to have an in-house corrective action program to continuously improve. Vendors' early challenges include presenting one face to OPG rather than a collection of joint venture partners. This presentation describes OPG's plans and early feedback on this exciting new initiative.

  11. Interactions between endothelial progenitor cells (EPC) and titanium implant surfaces.

    Science.gov (United States)

    Ziebart, Thomas; Schnell, Anne; Walter, Christian; Kämmerer, Peer W; Pabst, Andreas; Lehmann, Karl M; Ziebart, Johanna; Klein, Marc O; Al-Nawas, Bilal

    2013-01-01

    Endothelial cells play an important role in peri-implant angiogenesis during early bone formation. Therefore, interactions between endothelial progenitor cells (EPCs) and titanium dental implant surfaces are of crucial interest. The aim of our in vitro study was to investigate the reactions of EPCs in contact with different commercially available implant surfaces. EPCs from buffy coats were isolated by Ficoll density gradient separation. After cell differentiation, EPC were cultured for a period of 7 days on different titanium surfaces. The test surfaces varied in roughness and hydrophilicity: acid-etched (A), sand-blasted-blasted and acid-etched (SLA), hydrophilic A (modA), and hydrophilic SLA (modSLA). Plastic and fibronectin-coated plastic surfaces served as controls. Cell numbers and morphology were analyzed by confocal laser scanning microscopy. Secretion of vascular endothelial growth factor (VEGF)-A was measured by enzyme-linked immunosorbent assay and expressions of iNOS and eNOS were investigated by real-time polymerase chain reaction. Cell numbers were higher in the control groups compared to the cells of titanium surfaces. Initially, hydrophilic titanium surfaces (modA and modSLA) showed lower cell numbers than hydrophobic surfaces (A and SLA). After 7 days smoother surfaces (A and modA) showed increased cell numbers compared to rougher surfaces (SLA and modSLA). Cell morphology of A, modA, and control surfaces was characterized by a multitude of pseudopodia and planar cell soma architecture. SLA and modSLA promoted small and plump cell soma with little quantity of pseudopodia. The lowest VEGF level was measured on A, the highest on modSLA. The highest eNOS and iNOS expressions were found on modA surfaces. The results of this study demonstrate that biological behaviors of EPCs can be influenced by different surfaces. The modSLA surface promotes an undifferentiated phenotype of EPCs that has the ability to secrete growth factors in great quantities. In

  12. Test Report : GS Battery, EPC power HES RESCU

    Energy Technology Data Exchange (ETDEWEB)

    Rose, David Martin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schenkman, Benjamin L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Borneo, Daniel R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-10-01

    The Department of Energy Office of Electricity (DOE/OE), Sandia National Laboratories (SNL) and the Base Camp Integration Lab (BCIL) partnered together to incorporate an energy storage system into a microgrid configured Forward Operating Base to reduce the fossil fuel consumption and to ultimately save lives. Energy storage vendors will be sending their systems to SNL Energy Storage Test Pad (ESTP) for functional testing and then to the BCIL for performance evaluation. The technologies that will be tested are electro-chemical energy storage systems comprising of lead acid, lithium-ion or zinc-bromide. GS Battery and EPC Power have developed an energy storage system that utilizes zinc-bromide flow batteries to save fuel on a military microgrid. This report contains the testing results and some limited analysis of performance of the GS Battery, EPC Power HES RESCU.

  13. Nudging and residential energy use. Its potential for the EPC

    OpenAIRE

    Taranu, Victoria; Verbeeck, Griet

    2015-01-01

    The implications of nudging in reducing residential energy demand and its potential for the EPC. Recently there is an increasing interest among policy makers, researchers and social marketing activists towards nudging. This approach takes into account the heuristic thinking of the individuals, who do not always act according to utility maximization principles. Current policies aiming the reduction of energy consumption include soft policies of libertarian pa...

  14. New EPC-calculation [Energy Efficiency Coefficient]. A few building engineering changes; Nieuwe EPC-bepaling. Enkele bouwtechnische wijzigingen

    Energy Technology Data Exchange (ETDEWEB)

    Spiekman, M.E.; Van Dijk, H.A.L. [TNO Built Environment, Delft (Netherlands)

    2012-06-15

    On July 1st 2012 the existing standards for energy performance of new residential buildings (NEN 5128) and non-residential buildings (NEN 2916) are replaced by a new standard (NEN 7120) in which, next to dwellings and non-residential buildings, new and existing buildings are integrated. In this article the most important changes are described. [Dutch] Vanaf 1 juli worden de bestaande energieprestatienormen voor nieuwbouwwoningen (NEN 5128) en utiliteitsbouw (NEN 2916) vervangen door een nieuwe norm, de NEN 7120. Voorheen waren ervoor de bepaling van de energieprestatiecoefficient (EPC) voor woningen en utiliteitsbouw aparte bepalingsmethoden voorhanden. Ook waren de bepaling van de EPC voor nieuwbouw en de Energie-Index (EI) voor het energielabel voor bestaande bouw (ISSO 82, ISSO 75) in aparte documenten vastgelegd. De nieuwe norm NEN 7120 is voor al deze gebouwcategorieen te gebruiken en zal de huidige bepalingsmethoden vervangen.

  15. PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years` experience at St John`s Institute of Dermatology

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, C.R.; Hawk, J.L.M. [St Thomas` Hospital, London (United Kingdom). St John`s Institute of Dermatology

    1995-12-01

    Our 10-year experience with PUVA treatment for alopecia areata, partialis, totalis and universalis was retrospectively reviewed using charts and follow-up questionnaires for 70 patients at St John`s Institute of Dermatology. In all cases, several previous therapies were judged to be unsatisfactory prior to starting PUVA, and many cases were already deemed clinically refractory prior to referral for PUVA. If cases of vellus hair growth are excluded, and those who lost their PUVA-induced regrowth rapidly on follow-up, the effective success rate was at best 6.3% for alopecia areata partialis, 12.5% for alopecia areata totalis and 13.3% for alopecia areata universalis. We affirm that PUVA is generally not an effective treatment for alopecia areata. (Author).

  16. Endothelial progenitor cells (EPCs) in ageing and age-related diseases: How currently available treatment modalities affect EPC biology, atherosclerosis, and cardiovascular outcomes.

    Science.gov (United States)

    Altabas, Velimir; Altabas, Karmela; Kirigin, Lora

    2016-10-01

    Endothelial progenitor cells (EPCs) are mononuclear cells that circulate in the blood and are derived from different tissues, expressing cell surface markers that are similar to mature endothelial cells. The discovery of EPCs has lead to new insights in vascular repair and atherosclerosis and also a new theory for ageing. EPCs from the bone marrow and some other organs aid in vascular repair by migrating to distant vessels where they differentiate into mature endothelial cells and replace old and injured endothelial cells. The ability of EPCs to repair vascular damage depends on their number and functionality. Currently marketed drugs used in a variety of diseases can modulate these characteristics. In this review, the effect of currently available treatment options for cardiovascular and metabolic disorders on EPC biology will be discussed. The various EPC-based therapies that will be discussed include lipid-lowering agents, antihypertensive agents, antidiabetic drugs, phosphodiesteraze inhibitors, hormones, as well as EPC capturing stents. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. Nuclear power equipment procurement management under EPC mode

    International Nuclear Information System (INIS)

    Shuai Yuezhi

    2014-01-01

    Nuclear power equipment procurement is one of the major constraints and management difficulties in the process of domestic nuclear power project construction for a long time. The construction of Hainan Changjiang Project can not meet the milestones due to the major equipment supply delay. Through the introduction to the organization and features of Changjiang project equipment procurement under EPC mode, and the main problems in the procurement process and its reason analysis, the purpose of this paper is to put forward ideas and suggestions of these items, i.e. selection of equipment suppliers, equipment localization, mass material design and procurement, complete system equipment supply, spare parts delivery and storage, owner process management, providing reference for follow-up projects. (author)

  18. A quantitative analysis of faulty EPCs in the SAP reference model

    NARCIS (Netherlands)

    Mendling, J.; Moser, M.; Neumann, G.; Verbeek, H.M.W.; Dongen, van B.F.; Aalst, van der W.M.P.

    2006-01-01

    The SAP reference model contains more than 600 non-trivial process models expressed in terms of Event-driven Process Chains (EPCs). We have automatically translated these EPCs into YAWL models and analyzed these models usingWofYAWL, a veri¯cation tool based on Petri nets. We discovered that at least

  19. Environmental benefits from energy efficiency - a study of environmental aspects of EPC-projects; Miljoenytta med energieffektivisering - en studie av miljoeaspektens roll i EPC-projekt

    Energy Technology Data Exchange (ETDEWEB)

    Axelsson, Ulrik; Gottberg, Annika; Gode, Jenny; Saernholm, Erik

    2010-05-15

    Energy Performance Contracting (EPC) is an energy service which means that investments in energy saving measures are financed by means of guarantied energy savings. Since the measures are financed by estimated savings, an overall perspective on the energy performance, operating costs and indoor climate of a building or a whole building complex becomes possible. EPC thereby provides a possibility to more far-reaching energy saving measures which would otherwise not be tolerated within the operating budget. The environmental benefit such as reduced climate impact, can in some cases even be the overall objective and energy saving a way to achieve that objective. This study has investigated four EPC projects performed by public organisations in Sweden. The aim has been to analyse to what extent environmental benefit is a decision parameter in the EPC process and to develop a method and a calculating tool that make it possible for different EPC suppliers to use a common method to show the environmental benefit of the energy saving measure. Our main conclusion from this study is that the environmental issue is an important part of a EPC project but it can not be considered to be a well-functioning decision parameter. Today other parameters such as maintenance needs, modernisation, indoor climate and cost savings are the most important at the early stage for the employee of the public organisation. However, the environmental benefit could be highlighted already at this stage to show that those other advantages can be achieved with higher or lower environmental benefit, and to make sure that the political environmental benefit becomes a more important factor in the procurement process (after a political decision). An experience from the study is that for the environmental issue to play a mayor role in the realisation of an EPC project it must be involved already before the decision to perform an EPC project. This is true specially if the supplier are expected to optimise

  20. Study on the Selection of Equipment Suppliers for Wind Power Generation EPC Project

    Science.gov (United States)

    Yang, Yuanyue; Li, Huimin

    2017-12-01

    In the EPC project, the purchase cost of equipments accounted for about 60% of the total project cost, thus, the selection of equipment suppliers has an important influence on the EPC project. This paper, took EPC project for the phase I engineering of Guizhou Huaxi Yunding wind power plant as research background, constructed the evaluation index system for the selection of equipment suppliers for wind power generation EPC project from multiple perspectives, and introduced matter-element extension evaluation model to evaluate the selection of equipment suppliers for this project from the qualitative and quantitative point of view. The result is consistent with the actual situation, which verifies the validity and operability of this method.

  1. HSE management for AP1000 nuclear plant construction in EPC mode

    International Nuclear Information System (INIS)

    He Xiaogang; Wei Zhong

    2010-01-01

    As a new nuclear type, AP1000 will become the development direction of Chinese nuclear project. EPC General Contract mode is favored by nuclear owners both at home and abroad. Therefore, there is necessity for studying HSE management system and method suitable for AP1000 nuclear plant construction (ANPC) based on combination of AP1000 construction characters in EPC mode. This can not only ensure safety for ANPC but also positively promote national nuclear power development. For this reason, based on site HSE management of the first AP1000 nuclear plant under construction, HSE management system and method for ANPC in EPC mode was proposed after analysis of the character of EPC mode and ANPC character. It is hoped that it will be helpful for safe construction for ANPC. (authors)

  2. Environmental profiles on chemicals (EPC): A substitution tool i.a. used in the textile industry

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Hansen, John; Laursen, Søren E.

    2002-01-01

    When dealing with cleaner technology and product development within industries using a lot of different chemicals, substitution is essential. In many cases substitution of hazardous chemicals with less hazardous ones will diminish the environmental impact from the industry in question. But among...... many different chemicals it can be difficult to prioritize and evaluate areas for substitution. The EPC-tool was thus developed and it has been used successfully within the Danish printing industry and the Polish textile industry. The EPC tool combines key emission and key consumption figures...... with hazard assessments of the chemicals used in production and thus creates an environmental profile of the industry, process or product in question. The preceding EPCs are used for pointing out hazardous chemicals used in relatively high quantities and therefore candidates for substitution. The EPCs created...

  3. Design management of general contractor under nuclear power project EPC mode

    International Nuclear Information System (INIS)

    Su Shaojian

    2013-01-01

    Design management has not yet formed a theoretical system recognized, general contractor design managers under nuclear power project EPC Mode lack the clear theory basis. This paper aims to discuss Design management from the angle of general contractor under nuclear power project EPC mode, Gives the concept of design management Clearly, by Combining the characteristics of nuclear power project, Gives the specific content and meaning of the design management of nuclear power project. (authors)

  4. Enhanced electrochemical sensitivity of enzyme precipitate coating (EPC)-based glucose oxidase biosensors with increased free CNT loadings.

    Science.gov (United States)

    Kim, Jae Hyun; Jun, Sun-Ae; Kwon, Yongchai; Ha, Su; Sang, Byong-In; Kim, Jungbae

    2015-02-01

    Enzymatic electrodes were fabricated by using three different immobilizations of glucose oxidase (GOx): covalent enzyme attachment (CA), enzyme coating (EC), and enzyme precipitate coating (EPC), here referred to as CA-E, EC-E, and EPC-E, respectively. When additional carbon nanotubes (CNTs) were introduced from 0 to 75wt% for the EPC-E design, its initial biosensor sensitivity was improved from 2.40×10(-3) to 16.26×10(-3) A∙M(-1)∙cm(-2), while its electron charge transfer rate constant was increased from 0.33 to 1.47s(-1). When a fixed ratio of CNTs was added for three different electrode systems, EPC-E showed the best glucose sensitivity and long-term thermal stability. For example, when 75wt% of additional CNTs was added, the initial sensitivity of EPC-E was 16.26×10(-3) A∙M(-1)∙cm(-2), while those of EC-E and CA-E were only 6.42×10(-3) and 1.18×10(-3) A∙M(-1)∙cm(-2), respectively. Furthermore, EPC-E retained 63% of its initial sensitivity after thermal treatment at 40°C over 41days, while EC-E and CA-E showed only 12% and 1% of initial sensitivities, respectively. Consequently, the EPC approach with additional CNTs achieved both high sensitivity and long-term stability, which are required for continuous and accurate glucose monitoring. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Hemicrania continua: clinical review, diagnosis and management

    Directory of Open Access Journals (Sweden)

    Prakash S

    2017-06-01

    Full Text Available Sanjay Prakash,1 Payal Patel2 1Department of Neurology, Smt. B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth University, Vadodara, Gujarat, India; 2Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH, USA Abstract: Hemicrania continua (HC is an indomethacin-responsive primary headache disorder which is currently classified under the heading of trigeminal autonomic cephalalgias (TACs. It is a highly misdiagnosed and underreported primary headache. The pooled mean delay of diagnosis of HC is 8.0 ± 7.2 years. It is not rare. We noted more than 1000 cases in the literature. It represents 1.7% of total headache patients attending headache or neurology clinic. Just like other TACs, it is characterized by strictly unilateral pain in the trigeminal distribution, cranial autonomic features in the same area and agitation during exacerbations/attacks. It is different from other TACs in one aspect. While all other TACs are episodic, HC patients have continuous headaches with superimposed severe exacerbations. The central feature of HC is continuous background headache. However, the patients may be worried only for superimposed exacerbations. Focusing only on exacerbations and ignoring continuous background headache are the most important factors for the misdiagnosis of HC. A large number of patients may have migrainous features during exacerbation phase. Up to 70% patients may fulfill the diagnostic criteria for migraine during exacerbations. Besides migraine, its exacerbations can mimic a large number of other primary and secondary headaches. The other specific feature of HC is a remarkable response to indomethacin. However, a large number of patients develop side effects because of the long-term use of indomethacin. A few other medications may also be effective in a subset of patients with HC. Various surgical interventions have been suggested for patients who are intolerant to indomethacin. Several aspects of HC

  6. Success factors of energy performance contracting (EPC) for sustainable building energy efficiency retrofit (BEER) of hotel buildings in China

    International Nuclear Information System (INIS)

    Xu Pengpeng; Chan, Edwin Hon-Wan; Queena Kun Qian

    2011-01-01

    Hotel building is a type of high-energy-consuming building and most existing hotel buildings need energy efficiency improvement in China. Energy performance contracting (EPC) is considered a win-win mechanism to organize building energy efficiency retrofit (BEER) project. However, EPC mechanism has been introduced into China relatively recently and many EPCs have not been successful in building energy efficiency retrofit projects. This research aims to develop a set of critical success factors (CSFs) of EPC for sustainable energy efficiency retrofit (BEER) of hotel buildings in China. Semi-structured interviews and a questionnaire survey with practitioners and other professionals were conducted. The findings reveal the relative importance of the 21 number of identified success factors. In order to explore the underlying relationship among the identified critical success factors (CSFs), factor analysis method was adopted for further investigation, which leads to grouping the 21 identified CSFs into six clusters. These are (1) project organization process, (2) EPC project financing for hotel retrofit, (3) knowledge and innovation of EPC, sustainable development (SD), and M and V, (4) implementation of sustainable development strategy, (5) contractual arrangement, and (6) external economic environment. Finally, several relevant policies were proposed to implement EPC successfully in sustainable BEER in hotel buildings. - Highlights: → EPC is a win-win mechanism to organize building energy efficiency retrofit project. → CSFs of EPC mechanism for sustainable BEER of hotel building in China are examined. → Six clusters are extracted from 21 identified CSFs based on factor analysis.

  7. Project quality management under EPC mode by the owner of nuclear power plant

    International Nuclear Information System (INIS)

    Xu Hui; Hu Miao

    2014-01-01

    As the first completely independent nuclear power project in China, Fangjiashan nuclear power project is constructed under EPC mode of general project contracting. This paper, taking the project as an example, aims to explore how the project owners carry out quality management for the installation project during the construction of the nuclear power plant based on EPC mode. It has certain reference value for the management of following nuclear power projects which adopting the EPC construction mode. It will play a positive role in improving China's overall self-management abilities in the nuclear power construction, and lay a solid foundation for follow-up nuclear power construction in China. (authors)

  8. β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.

    Science.gov (United States)

    Vafaei, Rana; Nassiri, Seyed Mahdi; Siavashi, Vahid

    2017-12-01

    Mesenchymal stem cells (MSCs) reside in a specific niche in the bone marrow, however, biological features of this niche are still not fully understood. Given the interactions of MSCs with endothelial cells in different tissues, bone marrow MSC niche may influence the biological features of endothelial progenitor cells (EPCs). To understand the role of the sympathetic nervous system in regulation of the MSC niche, we examined whether the manipulation of the MSC niche via β3-adrenergic signals will affect EPC features. A selective β3 agonist (BRL37344) or a β3 antagonist (SR59230A) was administered in mice for 2 weeks to determine the potential effects of these regimens on the population of CD133 + stem cells in the bone marrow. Then, bone marrow-derived MSCs and EPCs were harvested and expanded from the mice to examine the effect of changes in the MSC niche on EPC features. Improved MSC colony forming potency with increased bone marrow stromal cell-derived factor 1 (SDF-1) (also known as C-X-C motif chemokine 12 [CXCL12]) expression was shown as a result of intensification of the bone marrow adrenergic signals through BRL37344 injection. On the other hand, the blockage of these signals limited the expression level of SDF-1 and resulted in bone marrow enrichment of CD133 + cells. Manipulation of the MSC niche and decreased SDF-1 expression via SR59230A injection also prompted EPCs to form more colonies with augmented proliferation and differentiation capacity. Overall, our results indicate that the β3-adrenergic signals regulate the MSC niche, thereby resulting in modulation of EPC biological features. J. Cell. Biochem. 118: 4753-4761, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  9. Introducing an electronic Palliative Care Summary (ePCS) in Scotland: patient, carer and professional perspectives.

    Science.gov (United States)

    Hall, Susan; Murchie, Peter; Campbell, Christine; Murray, Scott A

    2012-10-01

    An electronic Palliative Care Summary (ePCS) is currently being implemented throughout Scotland to provide out-of-hours (OOH) staff with up-to-date summaries of medical history, patient understanding and wishes, medications and decisions regarding treatment of patients requiring palliative care: automatic twice daily updates of information from GP records to a central electronic repository are available to OOH services. To identify key issues related to the introduction of ePCS from primary care and OOH staff, to identify facilitators and barriers to their use, to explore the experiences of patients and carers and to make recommendations for improvements. Twenty-two semi-structured interviews were carried out with a purposive sample of health professionals [practice nurses (3 interviews), GPs (12 interviews), a practice manager (1 interview) from practices using different computing software systems] and patients and/or carers (6 interviews for whom an ePCS had been completed). Interviews were digitally recorded, transcribed and analysed thematically. Patients and carers were reassured that OOH staff were informed about their current circumstances. OOH staff considered the ePCS allowed them to be better informed in decision making and in carrying out home visits. GPs viewed the introduction of ePCSs to have benefits for in-hours structures of care including advance care planning. No interviewee expressed concern about confidentiality. Barriers raised related to the introduction of new technology including unfamiliarity with the process, limited time and information technology skills. The ePCS has clear potential to improve patient care although several implementation issues and technical problems require to be addressed first to enable this. GPs and community nurses should identify more patients with malignant and non-malignant illnesses for completion of the ePCS.

  10. Consideration of sharing small term management under the EPC model on Nuclear power

    International Nuclear Information System (INIS)

    Yu Yong

    2012-01-01

    The special nature and importance of sharing small term under management of nuclear power EPC mode were discussed. Advantages and disadvantages of EPC mode on nuclear power.engineering is analyzed. Pointed out the management problems of owners, general contracting units, equipment suppliers and engineering construction units and other parties involved in the process of a common small term implementing. The recommendations concerning management of the owners and general contractors and subcontractors owners of nuclear power engineering inside during the management of the common aspects of sharing small term were made

  11. El sistema integral de educación continua.

    OpenAIRE

    Velazco Lozada, Ana

    2014-01-01

    La Educación Continua es concebida como un instrumento educativo que fomenta un mayor desarrollo personal y profesional de los seres humanos, el cual permite que se refleje en cambios concretos en los distintos sectores productivos del país. Educación Continua empieza en la edad pre – escolar, hasta los post grados, re – entrenamientos, calificaciones y autoeducación, lo que permite al ser humano a través de la capacitación constante mejorar su calidad de vida y además con ello...

  12. Tobacco arabinogalactan protein NtEPc can promote banana (Musa AAA) somatic embryogenesis.

    Science.gov (United States)

    Shu, H; Xu, L; Li, Z; Li, J; Jin, Z; Chang, S

    2014-12-01

    Banana is an important tropical fruit worldwide. Parthenocarpy and female sterility made it impossible to improve banana varieties through common hybridization. Genetic transformation for banana improvement is imperative. But the low rate that banana embryogenic callus was induced made the transformation cannot be performed in many laboratories. Finding ways to promote banana somatic embryogenesis is critical for banana genetic transformation. After tobacco arabinogalactan protein gene NtEPc was transformed into Escherichia coli (DE3), the recombinant protein was purified and filter-sterilized. A series of the sterilized protein was added into tissue culture medium. It was found that the number of banana immature male flowers developing embryogenic calli increased significantly in the presence of NtEPc protein compared with the effect of the control medium. Among the treatments, explants cultured on medium containing 10 mg/l of NtEPc protein had the highest chance to develop embryogenic calli. The percentage of lines that developed embryogenic calli on this medium was about 12.5 %. These demonstrated that NtEPc protein can be used to promote banana embryogenesis. This is the first paper that reported that foreign arabinogalactan protein (AGP) could be used to improve banana somatic embryogenesis.

  13. The chainable continua are the spaces approximated by finite COTS

    Directory of Open Access Journals (Sweden)

    Judy A. Kennedy

    2001-10-01

    Full Text Available We show that the chainable continua (also called snake-like or arc-likecontinua, are precisely the Hausdorff reflections of inverse limits of sequences of finite COTS under maps which are continuous and are separating.

  14. Primary continuous unilateral headaches: a nosologic model for hemicrania continua.

    Science.gov (United States)

    Pareja, Juan A; Cuadrado, María-Luz; Fernández-de-las-Peñas, César; Montojo, Teresa; Álvarez, Mónica; López-de-Silanes, Carlos

    2012-04-01

    Hemicrania continua was originally described as a strictly unilateral, continuous headache with an absolute response to indomethacin. Recognition of an increasing number of patients with the same clinical features except for a lack of response to indomethacin has generated controversy about whether the responsive/non-responsive phenotypes belong to the same disorder. We suggest that the non-responsive phenotype should be differentiated from the original concept of hemicrania continua, because it probably indicates a separate type of headache of undetermined nature, i.e. hemicrania incerta. However, differentiating hemicrania incerta from hemicrania continua does not imply that the two headaches are unrelated. Both hemicranias may outline a continuum, giving rise to a broader diagnostic field. There seems to be a syndrome of 'primary continuous unilateral headache' with at least two distinctive categories: hemicrania continua and hemicrania incerta, which are differentiated by their respective response to indomethacin. This division means plurality but adds precision, and allows a clear-cut diagnosis of some controversial cases.

  15. Optical-to-Radio Continua in Solar Flares

    Czech Academy of Sciences Publication Activity Database

    Heinzel, Petr; Avrett, E.H.

    2012-01-01

    Roč. 227, č. 1 (2012), s. 31-44 ISSN 0038-0938 R&D Projects: GA ČR GAP209/10/1680 Institutional research plan: CEZ:AV0Z10030501 Keywords : solar flares * spectral continua * diagnostics Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 3.256, year: 2012

  16. Legal Analysis of EPC Contract of the Nuclear Reactor in the aspect of Nuclear Law

    International Nuclear Information System (INIS)

    Lee, D. S.; Chung, W. S.; Yun, S. W.; Yang, M. H.

    2010-01-01

    Recently, Korea Nuclear Industry and R and D Institute obtained order of Nuclear Reactor construction from the UAE and the Jordan. Though the UAE's nuclear power plant and the Jordan's Research Reactor were different each other legal issues raised in EPC contract between employer and contractor had very close characters and similar suggestions. New nuclear country have not established all necessary entities regarding regulation and control and enacted laws yet. However, nuclear technology shall be transferred to the country that is ready to or have equipped all mandatory safeguard and safety. From the reality, nuclear specific issues such as the Nuclear Indemnity, Ownership of Intellectual property, Training program for operating technicians, and nuclear licensing are emerging in the EPC contract and finding consensus to the issues between both parties were time consuming work. Our studies will analysis the issues and try to find impartial guideline

  17. Probabilistic finite elements for transient analysis in nonlinear continua

    Science.gov (United States)

    Liu, W. K.; Belytschko, T.; Mani, A.

    1985-01-01

    The probabilistic finite element method (PFEM), which is a combination of finite element methods and second-moment analysis, is formulated for linear and nonlinear continua with inhomogeneous random fields. Analogous to the discretization of the displacement field in finite element methods, the random field is also discretized. The formulation is simplified by transforming the correlated variables to a set of uncorrelated variables through an eigenvalue orthogonalization. Furthermore, it is shown that a reduced set of the uncorrelated variables is sufficient for the second-moment analysis. Based on the linear formulation of the PFEM, the method is then extended to transient analysis in nonlinear continua. The accuracy and efficiency of the method is demonstrated by application to a one-dimensional, elastic/plastic wave propagation problem. The moments calculated compare favorably with those obtained by Monte Carlo simulation. Also, the procedure is amenable to implementation in deterministic FEM based computer programs.

  18. Desarrollo de simuladores para procesos industriales. Parte I. (Colada continua

    Directory of Open Access Journals (Sweden)

    Ramírez, A.

    2006-06-01

    Full Text Available This work was written for illustrating the development of computer simulators for production process. As an example a simulator for continuous casting process was made, this is the most popular method to produce some steel products like billets and slabs. The simulator (SSCC was programmed by the present authors in C++; but mathematical procedures, algorithms and flow charts shown here can be used as a base in any other programming language. This is the first part of the work; it is focused to the development of some computational tools to describe the real continuous casting process

    Este trabajo se realiza con el objeto de ilustrar el desarrollo de simuladores para procesos industriales; como ejemplo se realizó un sistema de simulación para representar el proceso de colada continua que es el proceso más común para la producción de perfiles de acero. El sistema de simulación para colada continua (SSCC fue programado por los presentes autores en lenguaje C++; sin embargo, los procedimientos matemáticos, algoritmos y diagramas de flujo ilustrados en este trabajo pueden ser programados en cualquier lenguaje de programación. Esta primera parte del trabajo se enfoca a desarrollar herramientas de cálculo para representar lo que sucede físicamente durante el proceso de colada continua.

  19. Introduction of Behavioral Parameterization in the EPC Calculation Method and Assessment of Five Typical Urban Houses in Wallonia, Belgium

    Directory of Open Access Journals (Sweden)

    Stéphane Monfils

    2016-11-01

    Full Text Available The Energy Performance Certification (EPC of existing residential buildings has been designed to introduce energy efficiency as a comparative criterion for real-estate purchase choices, which should influence real-estate market value and stimulate energy saving investments. EPCs in Belgium are asset ratings, calculated with a standardized approach, which purposefully (and understandably takes the human factor out of the equations in order to allow the comparison of buildings. As a result, they often overestimate energy consumption and present discrepancies that do not allow appropriation of the results by potential buyers. This study proposes complementary EPC results, obtained by integrating the behavior of occupants in the calculation method. This paper first analyses the pool of behavioral uncertainties that influence the results of EPCs, describes a questionnaire built to gather additional data on households’ characteristics and energy consumption habits and proposes modifications to the calculation method. The complementary results are then compared to regulatory EPC results and real consumption data. Though acknowledging the necessity of a standardized EPC for dwellings’ comparison, this study completes it with data on the energy consumption-related behaviors to (partially close the gap between real and theoretical consumptions.

  20. Generalized continua as models for classical and advanced materials

    CERN Document Server

    Forest, Samuel

    2016-01-01

    This volume is devoted to an actual topic which is the focus world-wide of various research groups. It contains contributions describing the material behavior on different scales, new existence and uniqueness theorems, the formulation of constitutive equations for advanced materials. The main emphasis of the contributions is directed on the following items - Modelling and simulation of natural and artificial materials with significant microstructure, - Generalized continua as a result of multi-scale models, - Multi-field actions on materials resulting in generalized material models, - Theories including higher gradients, and - Comparison with discrete modelling approaches.

  1. Foundations of the non-linear mechanics of continua

    CERN Document Server

    Sedov, L I

    1966-01-01

    International Series of Monographs on Interdisciplinary and Advanced Topics in Science and Engineering, Volume 1: Foundations of the Non-Linear Mechanics of Continua deals with the theoretical apparatus, principal concepts, and principles used in the construction of models of material bodies that fill space continuously. This book consists of three chapters. Chapters 1 and 2 are devoted to the theory of tensors and kinematic applications, focusing on the little-known theory of non-linear tensor functions. The laws of dynamics and thermodynamics are covered in Chapter 3.This volume is suitable

  2. Deforestation of Peano continua and minimal deformation retracts☆

    Science.gov (United States)

    Conner, G.; Meilstrup, M.

    2012-01-01

    Every Peano continuum has a strong deformation retract to a deforested continuum, that is, one with no strongly contractible subsets attached at a single point. In a deforested continuum, each point with a one-dimensional neighborhood is either fixed by every self-homotopy of the space, or has a neighborhood which is a locally finite graph. A minimal deformation retract of a continuum (if it exists) is called its core. Every one-dimensional Peano continuum has a unique core, which can be obtained by deforestation. We give examples of planar Peano continua that contain no core but are deforested. PMID:23471120

  3. Approximate scattering wave functions for few-particle continua

    International Nuclear Information System (INIS)

    Briggs, J.S.

    1990-01-01

    An operator identity which allows the wave operator for N particles interacting pairwise to be expanded as products of operators in which fewer than N particles interact is given. This identity is used to derive appproximate scattering wave functions for N-particle continua that avoid certain difficulties associated with Faddeev-type expansions. For example, a derivation is given of a scattering wave function used successfully recently to describe the three-particle continuum occurring in the electron impact ionization of the hydrogen atom

  4. Engineering management at feasibility study stage of nuclear power plant under EPC mode

    International Nuclear Information System (INIS)

    Wang Zhiqiang

    2015-01-01

    After the investment reform by the State Council in 2004, NDRC carries out approval system for enterprises to invest in nuclear power plants. Feasibility study stage is a critical stage on the mainline of nuclear power project approval, which intersects with the license application, and engineering design. The owners of nuclear power plants are required stringently in engineering management. From the owners' management point of view under EPC mode, this paper sorts the preliminary project process for nuclear power plants, focusing on the management in the feasibility study stage. License application and engineering design management in the feasibility study stage are also discussed. (author)

  5. Application of EPC Standards and Mobile Networks Services to Enhance the Quality of Postal Service

    Directory of Open Access Journals (Sweden)

    Vaculik Juraj

    2015-02-01

    Full Text Available This article deals with new technologies and methods to optimize the transport and delivery of postal mails. Introduction of this article defines the technologies and procedures that postal operators have started to use. The main part of the article describes specific implemented solutions of several postal operators and their benefits. The last part shows using of EPC standards in a processes chain. The conclusion of the article is devoted to the evaluation of these technologies and their potential in the area of postal sector.

  6. Effects of Thermal Cycling on Control and Irradiated EPC 2nd Generation GaN FETs

    Science.gov (United States)

    Patterson, Richard L.; Scheick, Leif; Lauenstein, Jean-Marie; Casey, Megan; Hammoud, Ahmad

    2013-01-01

    The power systems for use in NASA space missions must work reliably under harsh conditions including radiation, thermal cycling, and exposure to extreme temperatures. Gallium nitride semiconductors show great promise, but information pertaining to their performance is scarce. Gallium nitride N-channel enhancement-mode field effect transistors made by EPC Corporation in a 2nd generation of manufacturing were exposed to radiation followed by long-term thermal cycling in order to address their reliability for use in space missions. Results of the experimental work are presented and discussed.

  7. Effects of Radiation and Long-Term Thermal Cycling on EPC 1001 Gallium Nitride Transistors

    Science.gov (United States)

    Patterson, Richard L.; Scheick, Leif; Lauenstein, Jean-Marie; Casey, Megan; Hammoud, Ahmad

    2012-01-01

    Electronics designed for use in NASA space missions are required to work efficiently and reliably under harsh environment conditions. These include radiation, extreme temperatures, and thermal cycling, to name a few. Data obtained on long-term thermal cycling of new un-irradiated and irradiated samples of EPC1001 gallium nitride enhancement-mode transistors are presented. This work was done by a collaborative effort including GRC, GSFC, and support the NASA www.nasa.gov 1 JPL in of Electronic Parts and Packaging (NEPP) Program

  8. Integrating RFID Technology and EPC Network into a B2B Retail Supply Chain: A Step Toward Intelligent Business Processes

    Directory of Open Access Journals (Sweden)

    Samuel Fosso Wamba

    2007-06-01

    Full Text Available This article introduces RFID technology and the EPC Network and investigates their potential for B-to-B eCommerce supply chain management. Based on empirical data gathered from four tightly interrelated firms from three layers of a supply chain, several scenarios integrating RFID and the EPC Network have been tested and evaluated. In the context of warehousing activities in one specific retail supply chain, the results indicate that i the business process approach seems quite appropriate to capture the real potential of RFID and the EPC Network; ii RFID technology and the EPC Network can improve the “shipping” and the “receiving” processes; iii they can automatically trigger some business processes; iv they foster a higher level of information sharing between supply chain members; and v they promote the emergence of new business processes such as “process-to-process,” “process-to-machine,” and “machine-to-machine.” The paper helps to improve our understanding of the real potential of RFID and the EPC Network for business processes.

  9. Tema 5. Circuitos de corriente continua y alterna (Curso 2009-2010)

    OpenAIRE

    Miret Marí, Juan José; Caballero Caballero, María Teresa; Espinosa Tomás, Julián; Pérez Rodríguez, Jorge

    2009-01-01

    1. Magnitudes y elementos de un circuito. Circuitos de corriente continua constante: componentes y análisis; 2. Circuitos de corriente alterna: componentes; 3. Circuitos de corriente alterna: análisis; 4. Oscilaciones eléctricas. Circuitos de corriente continua variable; 5. Electrónica: materiales semiconductores y diodos.

  10. Educación Continua para Trabajadores de la Salud

    Directory of Open Access Journals (Sweden)

    Ricardo Galán Morera

    1986-08-01

    Full Text Available

    Introducción

    En los países del tercer mundo la educación continua surge como una alternativa para la formación de adultos y es utilizada en programas de desarrollo implementados por el Estado.

    El SENA la ha definido como “el proceso de formación profesional integral que apunta a generar en el hombre las herramientas prácticas y conceptuales, necesarias para inscribirse críticamente en la realidad y transformarla en beneficio propio, de su familia y su comunidad y no solamente como capacitación para el trabajo. (1

    En el sector salud la educación continua se entiende “como una forma de educación para graduados o trabajadores en servicio, de cualquier nivel (profesional, técnico, auxiliar que busca perfeccionar su labor y al mismo tiempo solucionar problemas concretos de salud, mediante procesos educativos que cubren a todos los implicados, con técnicas que en lo posible, evitan el abandono o interrupción de su trabajo. Se ubica en el campo de la capacitación independientemente de la ubicación o categoría académica de sus ejecutores”.
    (2.

    Si consideramos la educación continua como una estrategia de capacitación, ésta, al igual que todo proceso de capacitación debe:

    1. Contribuir a solucionar problemas concretos de salud.
    2. Proporcionar conocimientos y destrezas diferenciales a los usuarios del programa, según su nivel educativo y laboral, con el propósito de que enfrenten el problema de salud desde diferentes ángulos.
    3. Permitir ubicar, personal y socialmente al capacitado.
    4. Proveer los medios y el apoyo necesario para que el capacitado pueda poner en práctica la información recibida en la capacitación.
    5. Proveer la información y la asesoría necesaria, hasta que las acciones de capacitación y el producto de éstas se consolide...

  11. An overview of training and technical communication of Chinese representative nuclear power engineering company of EPC mode

    International Nuclear Information System (INIS)

    Qi Ting; Zhang Xiangyu

    2015-01-01

    After the Fukushima severe accident, nuclear power development has been in stagnation in all over the world. The Chinese nuclear industry has a slowdown on new NPP construction. As a result, high level technique on safety and effective communication are required. For nuclear power engineering company with EPC mode, high quality on training and technical communication is the principal investment in order to achieve better service on engineering design, environmental impact assessment, environmental engineering design, and equipment supervision and so on. EPC mode requires wide range knowledge on almost every field related to nuclear on nuclear power engineering. In this paper, the author investigated the case of the only nuclear power engineering EPC company (CNPE) in China and present an overview on its training and technical communication both domestic and abroad. Basically, there are 4 main branches of training. The internal training focuses on specifically task (both management and technique), such as HSE training, QC training and quality and safety training. Long term education in the university is organized by cooperated mechanism. Code and platform training is partly carried out by international organization or company, and the experienced engineers coach makes up the other part. The communication is a large part since the EPC mode needs the information and requirements from the NPP entity, authority, and the other institutes, international organizations (like IAEA, NINE, IRSN, OECD, NRC and CEA etc.) and sometimes the public. The overview of the training and communication of the EPC company prevails the outline of its advantage on domestic communication and disadvantage on international technical communication. The paper can be a tool on the soft strength construction of company under EPC mode to broaden its business like consultation and training. Some advice is given by the author on the consultation and global communication in the future. (author)

  12. A Model for Sustainable Building Energy Efficiency Retrofit (BEER) Using Energy Performance Contracting (EPC) Mechanism for Hotel Buildings in China

    Science.gov (United States)

    Xu, Pengpeng

    Hotel building is one of the high-energy-consuming building types, and retrofitting hotel buildings is an untapped solution to help cut carbon emissions contributing towards sustainable development. Energy Performance Contracting (EPC) has been promulgated as a market mechanism for the delivery of energy efficiency projects. EPC mechanism has been introduced into China relatively recently, and it has not been implemented successfully in building energy efficiency retrofit projects. The aim of this research is to develop a model for achieving the sustainability of Building Energy Efficiency Retrofit (BEER) in hotel buildings under the Energy Performance Contracting (EPC) mechanism. The objectives include: • To identify a set of Key Performance Indicators (KPIs) for measuring the sustainability of BEER in hotel buildings; • To identify Critical Success Factors (CSFs) under EPC mechanism that have a strong correlation with sustainable BEER project; • To develop a model explaining the relationships between the CSFs and the sustainability performance of BEER in hotel building. Literature reviews revealed the essence of sustainable BEER and EPC, which help to develop a conceptual framework for analyzing sustainable BEER under EPC mechanism in hotel buildings. 11 potential KPIs for sustainable BEER and 28 success factors of EPC were selected based on the developed framework. A questionnaire survey was conducted to ascertain the importance of selected performance indicators and success factors. Fuzzy set theory was adopted in identifying the KPIs. Six KPIs were identified from the 11 selected performance indicators. Through a questionnaire survey, out of the 28 success factors, 21 Critical Success Factors (CSFs) were also indentified. Using the factor analysis technique, the 21 identified CSFs in this study were grouped into six clusters to help explain project success of sustainable BEER. Finally, AHP/ANP approach was used in this research to develop a model to

  13. Energy Efficiency Investments in Public Facilities - Developing a Pilot Mechanism for Energy Performance Contracts (EPCs) in Russia

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Meredydd; Roshchanka, Volha; Parker, Steven A.; Baranovskiy, Aleksandr

    2012-02-01

    : Russian public sector buildings tend to be very inefficient, which creates vast opportunities for savings. This report overviews the latest developments in the Russian legislation related to energy efficiency in the public sector, describes the major challenges the regulations pose, and proposes ways to overcome these challenges. Given Russia’s limited experience with energy performance contracts (EPCs), a pilot project can help test an implementation mechanism. This paper discusses how EPCs and other mechanisms can help harness energy savings opportunities in Russia in general, and thus, can be applicable to any Russian region.

  14. Kallikrein gene-modified EPCs induce angiogenesis in rats with ischemic hindlimb and correlate with integrin αvβ3 expression.

    Directory of Open Access Journals (Sweden)

    Shen Shen Fu

    Full Text Available BACKGROUND: Human tissue kallikrein (hTK plays an essential role in the physiological and pathological mechanisms of blood vessels. This study aimed to determine whether angiogenesis induced by endothelial progenitor cells (EPCs transduced with the adenovirus-mediated hTK gene could improve blood flow in rat hindlimb ischemia in vivo and to establish a promising mechanism in vitro. METHODS: EPCs transduced with adenovirus encoding hTK-162 (i.e., Ad/hTK-transduced EPCs or Ad/GFP-transduced EPCs were administered to Wister rats with hindlimb ischemia through therapeutic neovascularization. Muscular capillary density (MCD, blood flow (BF, and the number of myofibers were measured at days 7, 14, and 21 after treatment. Expressions of integrin αvβ3 and endothelial nitric oxide synthase (eNOS were detected on the surface of EPCs. RESULTS: MCD, BF, and the number of myofibers in rats with Ad/hTK-transduced EPCs remarkably increased at day 21 after treatment compared with rats with Ad/GFP-transduced EPCs or the control group (P<0.01. Expressions of integrin αvβ3 and eNOS protein on the surface of EPCs also increased in rats with Ad/hTK-transduced EPCs. The levels of integrin αvβ3 expression were reduced by PI3K and eNOS blockade, and the inhibitor of integrin αvβ3 abrogated the migration and adhesion of hTK-transduced EPCs (P<0.05. CONCLUSION: hTK gene delivery in vivo improves the natural angiogenic response to ischemia. The ability of hTK gene-transduced EPCs can be enhanced in vitro, in which integrin αvβ3 plays a role in the process.

  15. Performance analysis of different tuning rules for an isothermal CSTR using integrated EPC and SPC

    Science.gov (United States)

    Roslan, A. H.; Karim, S. F. Abd; Hamzah, N.

    2018-03-01

    This paper demonstrates the integration of Engineering Process Control (EPC) and Statistical Process Control (SPC) for the control of product concentration of an isothermal CSTR. The objectives of this study are to evaluate the performance of Ziegler-Nichols (Z-N), Direct Synthesis, (DS) and Internal Model Control (IMC) tuning methods and determine the most effective method for this process. The simulation model was obtained from past literature and re-constructed using SIMULINK MATLAB to evaluate the process response. Additionally, the process stability, capability and normality were analyzed using Process Capability Sixpack reports in Minitab. Based on the results, DS displays the best response for having the smallest rise time, settling time, overshoot, undershoot, Integral Time Absolute Error (ITAE) and Integral Square Error (ISE). Also, based on statistical analysis, DS yields as the best tuning method as it exhibits the highest process stability and capability.

  16. Real EPC. A method to assess the energy efficiency of newly built houses in practice; Reele EPC. Een methode voor de beoordeling van de energieprestatie van nieuwbouwwoningen in de praktijk

    Energy Technology Data Exchange (ETDEWEB)

    Menkveld, M.; Sipma, J.M. [ECN Beleidsstudies, Petten (Netherlands); Cozijnsen, E.; Leidelmeijer, K. [RIGO research en Advies, Amsterdam (Netherlands)

    2013-12-15

    In this report we describe a method to compare the energy performance in use with the energy performance calculation of newly build houses. We put the average real energy use of a project in the calculation method of the energy performance of new houses. In that way we could compare the energy performance of the building permit with the real performance in practice. Because the calculation method normalizes the energy use of a house by its user surface and surface of building shell, the energy performance of different projects could be compared also when the projects exist of different dwelling types. Also the energy performance of different energy concepts could be compared such as all-electric houses with a heat pump or houses with a gas fired condensing boiler [Dutch] Agentschap NL is betrokken bij veel nieuwbouwprojecten. Een grote vraag is altijd of in de praktijk ook de prestaties worden gehaald die van te voren werden verwacht. Agentschap NL heeft voorgesteld hiervoor een maat te ontwikkelen, namelijk de Reele EPC. ECN heeft deze methodiek uitgewerkt om van woningbouwprojecten de energieprestatie in de praktijk te vergelijken met de geplande EPC. Het idee is dat de energieprestatie in de praktijk wordt uitgedrukt in een reële EPC (de R-EPC)

  17. RFID technology and the EPC network as enablers of mobile business: a case study in a retail supply chain

    NARCIS (Netherlands)

    Wamba, S.F.; Bendavid, Y.; Lefebvre, L.A.; Lefebvre, E.

    2006-01-01

    The main objective of this study is to explore the impact of integrating Radio Frequency Identification (RFID) technology and the Electronic Product Code (EPC) network into one specific supply chain in the retail industry and investigate their potentials as enablers of Mobile Business (m-business).

  18. Cuadro de Mando ODUNPLUS y su mejora continua

    Directory of Open Access Journals (Sweden)

    Rafael H Soler-González

    2016-01-01

    Full Text Available Debido al desarrollo de nuevos mod elos de gestión, que han aumentado el número de objetivos e indicadores en pos del control y de una efectiva toma de decisiones, los cuadros de mando se han convertido en herramientas necesarias para el desarrollo exitoso de la gestión empresarial en los ú ltimos años. En medio del Proyecto Prometeo y la implementación del Balanced Scorecard en la Escuela Superior Politécnica de Chimborazo (ESPOCH, se ha creado una nueva herramienta informática denominada ODUN que tiene mejoras continuas y la hacen un produ cto a seguir. ODUNPLUS es una nueva versión de este cuadro de mando que está programado con herramientas y librerías libres de tecnología web y bajo Licencia Pública General de GNU (GPL que permite su libre distribución y uso. Este artículo expone las nu evas bondades del de Mando ODUNPLUS.

  19. A development of the equations of electromagnetism in material continua

    CERN Document Server

    Tiersten, Harry F

    1990-01-01

    This tract is based on lecture notes for a course in mechanics that has been offered at Rensselaer Polytechnic Institute on and off for the past twenty years. The course is intended to provide graduate students in mechanics with an understanding of electromagnetism and prepare them for studies on the interaction of the electric and magnetic fields with deformable solid continua. As such, it is imperative that the distinction between particle and continuum descriptions of matter be carefully made and that the distinction between that which is inherently linear and that which is intrinsically nonlinear be clearly delineated. Every possible effort has been made on my part to achieve these ends. I wish to acknowledge the contributions of a number of students and faculty who attended the lectures over the years and who, by their questions and suggestions, significantly improved some of the sections. This preface would not be complete if I did not point out that my interest in electromagnetism was initiated and my ...

  20. A Morphing framework to couple non-local and local anisotropic continua

    KAUST Repository

    Azdoud, Yan

    2013-05-01

    In this article, we develop a method to couple anisotropic local continua with anisotropic non-local continua with central long-range forces. First, we describe anisotropic non-local models based on spherical harmonic descriptions. We then derive compatible classic continuum models. Finally, we apply the morphing method to these anisotropic non-local models and present three-dimensional numerical examples to validate the efficiency of the technique. © 2013 Elsevier Ltd. All rights reserved.

  1. Melatonin responsive hemicrania continua in which indomethacin was associated with contralateral headache.

    Science.gov (United States)

    Hollingworth, Milo; Young, Tim M

    2014-05-01

    Headache is a well-documented side effect of indomethacin in the older medical literature; however, it has rarely been commented on in indomethacin-responsive hemicrania continua. We describe the case of a 60-year-old woman with left-sided hemicrania continua whose indomethacin treatment was associated with a continuous right-sided migraine. Her indomethacin therapy was discontinued heralding a return of her left-sided hemicrania continua and a resolution of her right-sided migraine. Her hemicrania continua then responded well to melatonin, with recurrence on stopping and improvement on restarting. This is the most detailed description of headache as a side effect of indomethacin in a headache patient we are aware of, and one of only a few reported cases of melatonin-responsive hemicrania continua. We review the evidence of headache as a side effect of indomethacin in order to highlight its importance in the treatment of headache disorders. We emphasize that indomethacin headache response may be more than simply a beneficial or neutral one and might be relevant to some cases of apparently indomethacin-resistant hemicrania continua. We hope this case may encourage clinicians to inquire about headache as a potential side effect of indomethacin. © 2013 American Headache Society.

  2. Study on microstructure and properties of Mg-alloy surface alloying layer fabricated by EPC

    Directory of Open Access Journals (Sweden)

    Chen Dongfeng

    2010-02-01

    Full Text Available AZ91D surface alloying was investigated through evaporative pattern casting (EPC technology. Aluminum powder (0.074 to 0.104 mm was used as the alloying element in the experiment. An alloying coating with excellent properties was fabricated, which mainly consisted of adhesive, co-solvent, suspending agent and other ingredients according to desired proportion. Mg-alloy melt was poured under certain temperature and the degree of negative pressure. The microstructure of the surface layer was examined by means of scanning electron microscopy. It has been found that a large volume fraction of network new phases were formed on the Mg-alloy surface, the thickness of the alloying surface layer increased with the alloying coating increasing from 0.3 mm to 0.5 mm, and the microstructure became compact. Energy dispersive X-ray (EDX analysis was used to determine the chemical composition of the new phases. It showed that the new phases mainly consist of β-Mg17Al12, in addition to a small quantity of inter-metallic compounds and oxides. A micro-hardness test and a corrosion experiment to simulate the effect of sea water were performed. The result indicated that the highest micro-hardness of the surface reaches three times that of the matrix. The corrosion rate of alloying samples declines to about a fifth of that of the as-cast AZ91D specimen.

  3. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis.

    Science.gov (United States)

    Párniczky, Andrea; Abu-El-Haija, Maisam; Husain, Sohail; Lowe, Mark; Oracz, Grzegorz; Sahin-Tóth, Miklós; Szabó, Flóra K; Uc, Aliye; Wilschanski, Michael; Witt, Heiko; Czakó, László; Grammatikopoulos, Tassos; Rasmussen, Ib Christian; Sutton, Robert; Hegyi, Péter

    2018-03-01

    Pediatric pancreatitis is an underdiagnosed disease with variable etiology. In the past 10-15 years the incidence of pediatric pancreatitis has increased, it is now 3.6-13.3 cases per 100,000 children. Up-to-date evidence based management guidelines are lacking for the pediatric pancreatitis. The European Pancreatic Club, in collaboration with the Hungarian Pancreatic Study Group organized a consensus guideline meeting on the diagnosis and management of pancreatitis in the pediatric population. Pediatric Pancreatitis was divided into three main clinical categories: acute pancreatitis, acute recurrent pancreatitis and chronic pancreatitis. Fifteen relevant topics (acute pancreatitis: diagnosis; etiology; prognosis; imaging; complications; therapy; biliary tract management; acute recurrent pancreatitis: diagnosis; chronic pancreatitis: diagnosis, etiology, treatment, imaging, intervention, pain, complications; enzyme replacement) were defined. Ten experts from the USA and Europe reviewed and summarized the available literature. Evidence was classified according to the GRADE classification system. Within fifteen topics, forty-seven relevant clinical questions were defined. The draft of the updated guideline was presented and discussed at the consensus meeting held during the 49th Meeting of European Pancreatic Club, in Budapest, on July 1, 2017. These evidence-based guidelines provides the current state of the art of the diagnosis and management of pediatric pancreatitis. Copyright © 2018 IAP and EPC. Published by Elsevier B.V. All rights reserved.

  4. Nonhost resistance to rust pathogens – a continuation of continua

    Directory of Open Access Journals (Sweden)

    Jan eBettgenhaeuser

    2014-12-01

    Full Text Available The rust fungi (order: Pucciniales are a group of widely distributed fungal plant pathogens, which can infect representatives of all vascular plant groups. Rust diseases significantly impact several crop species and considerable research focuses on understanding the basis of host specificity and nonhost resistance. Like many pathogens, rust fungi vary considerably in the number of hosts they can infect, such as wheat leaf rust (Puccinia triticina, which can only infect species in the genera Triticum and Aegilops, whereas Asian soybean rust (Phakopsora pachyrhizi is known to infect over 95 species from over 42 genera. A greater understanding of the genetic basis determining host range has the potential to identify sources of durable resistance for agronomically important crops. Delimiting the boundary between host and nonhost has been complicated by the quantitative nature of phenotypes in the transition between these two states. Plant-pathogen interactions in this intermediate state are characterized either by (1 the majority of accessions of a species being resistant to the rust or (2 the rust only being able to partially complete key components of its life cycle. This leads to a continuum of disease phenotypes in the interaction with different plant species, observed as a range from compatibility (host to complete immunity within a species (nonhost. In this review we will highlight how the quantitative nature of disease resistance in these intermediate interactions is caused by a continuum of defense barriers, which a pathogen needs to overcome for successfully establishing itself in the host. To illustrate continua as this underlying principle, we will discuss the advances that have been made in studying nonhost resistance towards rust pathogens, particularly cereal rust pathogens.

  5. Hemicrania continua: Case series presenting in an orofacial pain clinic.

    Science.gov (United States)

    Hryvenko, Iryna; Cervantes-Chavarría, Andrés R; Law, Alan S; Nixdorf, Donald R

    2018-01-01

    Aim of investigation Hemicrania continua (HC) is an uncommon primary headache and little is known of the characteristics of such patients managed in an orofacial pain setting. This study provides clinical features of HC, its association with other disorders, and treatment outcomes of patients managed in the TMD and Orofacial Pain Clinic at the University of Minnesota. Methods A retrospective review of patient records was undertaken. Inclusion criteria were a diagnosis of HC and confirmation at follow-up. Results Six of the 1617 new patients seen between 2015 and 2017 met the selection criteria. Four patients presented with "facial pain", one with "toothache" and one with "jaw pain". All were female with mean age 55 ± 10.5 years (range = 41-69). Headache characteristics included unilateral (R:L = 1:1) pain of moderate intensity with severe exacerbations in the distribution of V 1 (1/6), V 1  + V 2 (3/6) and V 1  + V 2  + V 3 (2/6). Lacrimation and photophobia were the most common associated symptoms. Patient presentations were complicated by multiple medical and comorbid diagnoses. All were diagnosed with temporomandibular disorder (TMD). Indomethacin alone was sufficient for adequate headache control in 2/6 patients with several add-on medications providing sustained pain relief. Conclusions Comorbid pain conditions can be expected in patients with HC presenting to orofacial pain clinics. Symptom presentation varies, and multimodal treatment approach is necessary for success.

  6. Educación Médica Continua (EMC

    Directory of Open Access Journals (Sweden)

    Jorge Dagnino Sepúlveda

    2007-08-01

    Full Text Available La educación médica continua (EMC puede ser definida como todo medio o conjunto de ellos dirigidos a cambiar la conducta de un médico de manera de mejorar permanentemente los resultados de su actuar con los pacientes, individualmente, en una comunidad o en un sistema de salud. Los modelos prevalentes de EMC no aseguran estos resultados, por lo que es necesario un esfuerzo sostenido y sistemático de todas las partes involucradas: los individuos, las escuelas de Medicina y sociedades científicas, los entes acreditadores y certificadores y las instituciones de salud. La EMC debe ser autodirigida, basada en la responsabilidad individual, iniciarse con la determinación de necesidades de aprendizaje fundada en la práctica diaria, seguir con la identificación de soluciones para los problemas o brechas encontrados, con un aprendizaje experimental y el uso secuencial de diferentes metodologías que mejor aseguren el cambio conductual, el impacto real en el cuidado de los pacientes y su mantención en el tiempo. Para ello, debe iniciarse en el pregrado de la escuela de Medicina, perfeccionarse en el postítulo y seguir durante toda la vida activa del médico. Basar la educación y la práctica en la mejor evidencia disponible, en un enfoque sistémico y en el mejoramiento de la calidad es la mejor esperanza para generar estos resultados y prolongarlos en el tiempo.

  7. Nonhost resistance to rust pathogens – a continuation of continua

    Science.gov (United States)

    Bettgenhaeuser, Jan; Gilbert, Brian; Ayliffe, Michael; Moscou, Matthew J.

    2014-01-01

    The rust fungi (order: Pucciniales) are a group of widely distributed fungal plant pathogens, which can infect representatives of all vascular plant groups. Rust diseases significantly impact several crop species and considerable research focuses on understanding the basis of host specificity and nonhost resistance. Like many pathogens, rust fungi vary considerably in the number of hosts they can infect, such as wheat leaf rust (Puccinia triticina), which can only infect species in the genera Triticum and Aegilops, whereas Asian soybean rust (Phakopsora pachyrhizi) is known to infect over 95 species from over 42 genera. A greater understanding of the genetic basis determining host range has the potential to identify sources of durable resistance for agronomically important crops. Delimiting the boundary between host and nonhost has been complicated by the quantitative nature of phenotypes in the transition between these two states. Plant–pathogen interactions in this intermediate state are characterized either by (1) the majority of accessions of a species being resistant to the rust or (2) the rust only being able to partially complete key components of its life cycle. This leads to a continuum of disease phenotypes in the interaction with different plant species, observed as a range from compatibility (host) to complete immunity within a species (nonhost). In this review we will highlight how the quantitative nature of disease resistance in these intermediate interactions is caused by a continuum of defense barriers, which a pathogen needs to overcome for successfully establishing itself in the host. To illustrate continua as this underlying principle, we will discuss the advances that have been made in studying nonhost resistance towards rust pathogens, particularly cereal rust pathogens. PMID:25566270

  8. Nonhost resistance to rust pathogens - a continuation of continua.

    Science.gov (United States)

    Bettgenhaeuser, Jan; Gilbert, Brian; Ayliffe, Michael; Moscou, Matthew J

    2014-01-01

    The rust fungi (order: Pucciniales) are a group of widely distributed fungal plant pathogens, which can infect representatives of all vascular plant groups. Rust diseases significantly impact several crop species and considerable research focuses on understanding the basis of host specificity and nonhost resistance. Like many pathogens, rust fungi vary considerably in the number of hosts they can infect, such as wheat leaf rust (Puccinia triticina), which can only infect species in the genera Triticum and Aegilops, whereas Asian soybean rust (Phakopsora pachyrhizi) is known to infect over 95 species from over 42 genera. A greater understanding of the genetic basis determining host range has the potential to identify sources of durable resistance for agronomically important crops. Delimiting the boundary between host and nonhost has been complicated by the quantitative nature of phenotypes in the transition between these two states. Plant-pathogen interactions in this intermediate state are characterized either by (1) the majority of accessions of a species being resistant to the rust or (2) the rust only being able to partially complete key components of its life cycle. This leads to a continuum of disease phenotypes in the interaction with different plant species, observed as a range from compatibility (host) to complete immunity within a species (nonhost). In this review we will highlight how the quantitative nature of disease resistance in these intermediate interactions is caused by a continuum of defense barriers, which a pathogen needs to overcome for successfully establishing itself in the host. To illustrate continua as this underlying principle, we will discuss the advances that have been made in studying nonhost resistance towards rust pathogens, particularly cereal rust pathogens.

  9. Modelización global del proceso de colada continua

    Directory of Open Access Journals (Sweden)

    Barco, J.

    2005-12-01

    Full Text Available In the continuous casting process the contribution of complicated physical phenomena has an important effect in the final quality of the product and productivity of the process. Moreover, the different physical phenomena do not act in isolation, they interact in a coupled way affecting the quality of the semiproduct. Therefore, a correct design and setting is a work that requires a good knowledge of the different phenomena that are present and their interactions. In this work, a simulation methodology that solves all the process as a whole is presented, where the variables of the process are the only boundary conditions. The interactions between the different phenomena are solved with the use of commercial applications (FLUENT and ABAQUS and home developed models.

    En el proceso de colada continua contribuyen complicados fenómenos físicos con un marcado efecto en la calidad final del producto y en la productividad del proceso. Además, los distintos fenómenos físicos no aparecen de forma aislada, sino que interactúan unos con otros de manera acoplada, afectando a la calidad del semiproducto. El correcto diseño y ajuste es, por lo tanto, una tarea que requiere un gran conocimiento tanto de los distintos fenómenos que intervienen como de sus interacciones. En este trabajo se presenta un novedoso método de simulación que resuelve el proceso en su conjunto, siendo las variables del proceso las únicas condiciones de contorno. Mediante la utilización conjunta de herramientas comerciales (FLUENT y ABAQUS y una serie de modelos de desarrollo propio se resuelven las interacciones entre los distintos fenómenos.

  10. RFID - EPC Código electrónico de producto como herramienta de control de merma

    Directory of Open Access Journals (Sweden)

    Yohany Andrés Jiménez Flórez

    2013-07-01

    Full Text Available La tecnología de identificación por radiofrecuencia o RFID, trabajando bajo el estándar de identificación global EPC (por sus siglas en inglés “Electrónic Product Code” ha revolucionado las cadenas de suministro a nivel global por su capacidad de incrementar la trazabilidad, visibilidad y eficiencia operativa, sin embargo, no ha sido abordado el impacto que puede tener como herramienta de seguridad para las compañías. Este trabajo presenta los hallazgos encontrados mediante el empleo de EPC como herramienta de seguridad y control al robo, comprobado por medio de una prueba piloto desarrollada durante un período de cuatro meses en un punto de venta en Colombia.

  11. Consigned regulatory control and effect of the owner's welding quality under the EPC mode in Fangjiashan nuclear power project

    International Nuclear Information System (INIS)

    Wang Qun; Gu Tao; Wei Lianfeng; Li Hongjun

    2012-01-01

    Under EPC management mode, how to optimize resources allocation and realize effective management and control over key control points is a big difficulty facing the owner. From the owner's point of view, and through summary of practices, the paper introduces and analyses the mode and effect of consigned regulatory control over the weld quality of Fangjiashan nuclear power project. And some recognitions and point of views on popularization of specialized and consigned regulatory control are put forward. (authors)

  12. Immobilization of serum albumin and peptide aptamer for EPC on polydopamine coated titanium surface for enhanced in-situ self-endothelialization

    International Nuclear Information System (INIS)

    Chen, Zhuoyue; Li, Quanli; Chen, Jialong; Luo, Rifang; Maitz, Manfred F.; Huang, Nan

    2016-01-01

    Restenosis and thrombosis are two major complications associated with vascular stents and grafts. The homing of circulating endothelial progenitor cells (EPCs) onto implant surfaces brings a new strategy to solve these problems by accelerating self -endothelialization in situ. Peptide aptamers with high affinity and specific recognition of EPCs can be immobilized to capture EPCs from the circulating blood. In this study, a biotinylated peptide aptamer (TPSLEQRTVYAK-GGGC-K-Biotin) for EPC, and bovine serum albumin (BSA) were co-immobilized onto titanium surface through avidin–biotin recognition to endow the surface with specific affinity for EPC and anti-platelet adhesion properties. Quartz crystal microbalance with dissipation (QCM-D), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and water contact angle measuring were adopted for coating characterization. EPC affinity and hemocompatibility of the coating were also investigated in vitro. The results demonstrated that aptamer and BSA co-immobilized surface significantly reduced platelet adhesion and fibrinogen adsorption/activation. Besides, such functional surface could remarkably enhance EPC adhesion, without affecting the behavior of endothelial cells (ECs) and smooth muscle cells (SMCs) obviously. The result shows the possibility of utilizing such a multifunctional surface in cardiovascular implants. - Highlights: • We construct a multifunctional surface based on immobilization of BSA and aptamer. • It can significantly reduce platelet adhesion and fibrinogen adsorption/activation. • Such functional surface could remarkably enhance EPC adhesion in vitro. • It can induce rapid self-endothelialization of the implant surface in situ in vivo. • It is possible to use such a multifunctional surface in cardiovascular implants.

  13. Immobilization of serum albumin and peptide aptamer for EPC on polydopamine coated titanium surface for enhanced in-situ self-endothelialization

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Zhuoyue, E-mail: 362947953@qq.com [Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031 (China); RegeMed Lab of Tissue Engineering, Faculty of Life Science, Northwest University, Xi' an, 710069 (China); Li, Quanli [College of Stomology, Anhui Medical University, Hefei, 230032 (China); Chen, Jialong [Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031 (China); College of Stomology, Anhui Medical University, Hefei, 230032 (China); Luo, Rifang [Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031 (China); Maitz, Manfred F. [Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031 (China); Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Dresden (Germany); Huang, Nan, E-mail: huangnan1956@163.com [Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031 (China)

    2016-03-01

    Restenosis and thrombosis are two major complications associated with vascular stents and grafts. The homing of circulating endothelial progenitor cells (EPCs) onto implant surfaces brings a new strategy to solve these problems by accelerating self -endothelialization in situ. Peptide aptamers with high affinity and specific recognition of EPCs can be immobilized to capture EPCs from the circulating blood. In this study, a biotinylated peptide aptamer (TPSLEQRTVYAK-GGGC-K-Biotin) for EPC, and bovine serum albumin (BSA) were co-immobilized onto titanium surface through avidin–biotin recognition to endow the surface with specific affinity for EPC and anti-platelet adhesion properties. Quartz crystal microbalance with dissipation (QCM-D), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and water contact angle measuring were adopted for coating characterization. EPC affinity and hemocompatibility of the coating were also investigated in vitro. The results demonstrated that aptamer and BSA co-immobilized surface significantly reduced platelet adhesion and fibrinogen adsorption/activation. Besides, such functional surface could remarkably enhance EPC adhesion, without affecting the behavior of endothelial cells (ECs) and smooth muscle cells (SMCs) obviously. The result shows the possibility of utilizing such a multifunctional surface in cardiovascular implants. - Highlights: • We construct a multifunctional surface based on immobilization of BSA and aptamer. • It can significantly reduce platelet adhesion and fibrinogen adsorption/activation. • Such functional surface could remarkably enhance EPC adhesion in vitro. • It can induce rapid self-endothelialization of the implant surface in situ in vivo. • It is possible to use such a multifunctional surface in cardiovascular implants.

  14. Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs

    Directory of Open Access Journals (Sweden)

    Shuai Huang

    2015-08-01

    Full Text Available Background/Aims: Prostate cancer (PCa is one of the most common malignant cancers and a major leading cause of cancer deaths in men. Cancer stem-like cells are shown to be highly tumorigenic, pro-angiogenic and can significantly contribute to tumor new vessel formation and bone marrow derived-EPCs (BM-EPCs are shown to recruit to the angiogenic switch in tumor growth and metastatic progression, suggesting the importance of targeting cancer stem cells (CSCs and EPCs for novel tumor therapies. Pristimerin, an active component isolated from Celastraceae and Hippocrateaceae, has shown anti-tumor effects in some cell lines in previous studies. However, the effect and mechanism of Pristimerin on CSCs and EPCs in PCa bone metastasis are not well studied. Methods: The effect of Pristimerin on PC-3 stem cell characteristics and metastasis were detected by spheroid formation, CD133 and CD44 protein expression, matrix-gel invasive assay and colony-formation assay in vitro, VEGF and pro-inflammatory cytokines expression by ELISA assay, and tumor tumorigenicity by X-ray and MR in NOD-SCID mice model in vivo. In addition, we also detected the effect of Pristimerin on VEGF-induced vasculogenesis and protein expression of BM-EPCs. Results: Pristimerin could significantly inhibit spheroid formation and protein expression of CD133 and CD44, reduce VEGF and pro-inflammation cytokines expression of PC-3 cell, and prevent the xenografted PC-3 tumor growth in the bone of nude mice. The present data also showed that Pristimerin significantly inhibited VEGF-induced vasculogenesis of BM-EPCs by suppressing the EPCs functions including proliferation, adhesion, migration, tube formation and inactivation the phosphorylation of VEGFR-2, Akt and eNOS. Conclusion: These data provide evidence that Pristimerin has strong potential for development as a novel agent against prostate bone metastasis by suppressing PC-3 stem cell characteristics and VEGF-induced vasculogenesis of BM-EPCs.

  15. The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants.

    Science.gov (United States)

    Achneck, Hardean E; Jamiolkowski, Ryan M; Jantzen, Alexandra E; Haseltine, Justin M; Lane, Whitney O; Huang, Jessica K; Galinat, Lauren J; Serpe, Michael J; Lin, Fu-Hsiung; Li, Madison; Parikh, Amar; Ma, Liqiao; Chen, Tao; Sileshi, Bantayehu; Milano, Carmelo A; Wallace, Charles S; Stabler, Thomas V; Allen, Jason D; Truskey, George A; Lawson, Jeffrey H

    2011-01-01

    Implantable and extracorporeal cardiovascular devices are commonly made from titanium (Ti) (e.g. Ti-coated Nitinol stents and mechanical circulatory assist devices). Endothelializing the blood-contacting Ti surfaces of these devices would provide them with an antithrombogenic coating that mimics the native lining of blood vessels and the heart. We evaluated the viability and adherence of peripheral blood-derived porcine endothelial progenitor cells (EPCs), seeded onto thin Ti layers on glass slides under static conditions and after exposure to fluid shear stresses. EPCs attached and grew to confluence on Ti in serum-free medium, without preadsorption of proteins. After attachment to Ti for 15 min, less than 5% of the cells detached at a shear stress of 100 dyne / cm(2). Confluent monolayers of EPCs on smooth Ti surfaces (Rq of 10 nm), exposed to 15 or 100 dyne/cm(2) for 48 h, aligned and elongated in the direction of flow and produced nitric oxide dependent on the level of shear stress. EPC-coated Ti surfaces had dramatically reduced platelet adhesion when compared to uncoated Ti surfaces. These results indicate that peripheral blood-derived EPCs adhere and function normally on Ti surfaces. Therefore EPCs may be used to seed cardiovascular devices prior to implantation to ameliorate platelet activation and thrombus formation. Copyright © 2010 Elsevier Ltd. All rights reserved.

  16. Removal of Oil and Grease as Emerging Pollutants of Concern (EPC in Wastewater Stream

    Directory of Open Access Journals (Sweden)

    Alade Abass O

    2011-12-01

    Full Text Available Wastewater characteristics, which depend on wastewater source, are increasingly becoming more toxic in recent times. The concentrations of oil and grease in wastewater streams have been observed to increase in wastewater stream with increasing adverse effects on the ecology. This results from the increasing use of oil and grease in high-demanded oil-processed foods, establishment and expansion of oil mills and refineries worldwide, as well as indiscriminate discharge of oil and grease into the water drains, domestically and industrially. This study reports the applications, efficiencies and challenges of the wastewater treatment techniques currently employed in the removal of oil and grease from the industrial wastewater and municipal water stream. The results shows that the concentrations of oil and grease injected into the ecosystem are of higher environmental impact and this needs to be given the desired attention. The desired development for effective removal of oil and grease as emerging pollutants of concern (EPC in wastewater stream are thus proposed. ABSTRAK: Ciri-ciri air sisa, bergantung kepada punca air sisa tersebut, menjadi semakin toksik akhir-akhir ini. Kepekatan minyak dan gris dalam air sisa anak sungai dilihat makin bertambah dalam air sisa anak sungai dengan bertambahnya kesan negatif ke atas ekologi. Ini disebabkan oleh peningkatan penggunaan minyak dan gris dalam makanan berproses yang tinggi permintaannya, penubuhan dan perkembangan kilang pertroleum dan loji penapisan di seluruh dunia. Minyak dan gris juga dibuang sewenang-wenangnya ke dalam parit air, dari kalangan domestik dan industry. Kajian ini membentangkan tentang aplikasi, keberkesanan dan teknik cabaran rawatan air buangan yang kini digunakan dalam pembuangan minyak dan gris dari air sisa industry dan air sungai perbandaran. Keputusan menunjukkan kepekatan minyak dan gris yang wujud dibuang ke dalam ekosistem mempunyai impak yang lebih tinggi terhadap persekitaran

  17. EL PROFESORADO COMO AGENTE DE CAMBIO EN ESPACIOS DE FORMACIÓN CONTINUA

    Directory of Open Access Journals (Sweden)

    Patricia Raquimán Ortega

    2008-01-01

    Full Text Available Esta propuesta2 pretende ser una aproximación y reflexión hacia el concepto de formación continua como un proceso de cambio profesional, en el contexto del aprendizaje de adultos, específicamente profesores en ejercicio. Investigaciones y literatura sobre el cambio en educación y la formación en adultos, han servido de base para el diálogo que este texto ha querido desarrollar, como un espacio para la reflexión y la apertura a nuevas interrogantes en el contexto de la formación continua profesional en educación.

  18. Aportaciones al estudio de la respuesta con la temperatura de las HFETs en continua

    OpenAIRE

    González Pérez, Benito

    2011-01-01

    Programa de doctorado: Ingeniería Electrónica. Premio Extraordinario, Área de Tecnológicas En esta memoria se presentan los resultados de las investigaciones realizadas sobre la influencia de la temperatura en el funcionamiento de los HFETs, cuando operan en régimen de continua.

  19. Persistencia de Preconcepciones sobre los Circuitos Eléctricos de Corriente Continua

    OpenAIRE

    Solano,F.; Gil,J.; Pérez,A.L.; Suero,M.I.

    2002-01-01

    En este trabajo pretendemos comprobar que las preconcepciones que los alumnos poseen sobre los circuitos eléctricos de corriente continua son comunes a alumnos de diferentes edades y están tan fuertemente arraigadas que ni la instrucción durante muchos años permite modificarlas.

  20. MODELO ESTRATÉGICO DE MEJORA CONTINUA PARA LA PEQUEÑA Y MEDIANA EMPRESA MEXICANA

    Directory of Open Access Journals (Sweden)

    Aleida González González

    2007-12-01

    Full Text Available

     Las organizaciones en la búsqueda de la competitividad global tienen la necesidad de lograr productos y servicios al menor costo, con el mejor nivel de calidad y con la capacidad de responder a la demanda tanto en tiempo como en cantidad. El presente artículo, señala el diseño de un modelo estratégico de mejora continua, destinado a la pequeña y mediana organización con tendencia a la mejora continua. El modelo propone el diseño a través del proceso estratégico de mejora continua, basado en las normas ISO- 9000-2000. Está respaldado en los cinco procesos centrales: Organización, proceso estratégico, formación de personal, gestión de competencias laborales y servicio al cliente. Desde este punto de vista, el presente modelo facilita la mejora continua promoviendo el cambio cultural en las organizaciones y mejorar la eficiencia y eficacia.

  1. Interaction between resonances through autoionization continua near the 4s-threshold in KrII

    International Nuclear Information System (INIS)

    Demekhin, Ph V; Petrov, I D; Lagutin, B M; Sukhorukov, V L; Vollweiler, F; Klumpp, S; Ehresmann, A; Schartner, K-H; Schmoranzer, H

    2005-01-01

    The interaction between resonances through autoionization continua and the interaction between autoionization continua were investigated theoretically and experimentally for the photoionization process of the 4p- and 4s-shells and for the population of 4p 4 ( 3 P)5s 4 P J , 4p 4 ( 3 P)5s 2 P J and 4p 4 ( 3 P)4d 4 D J satellites of KrII. Cross sections for the satellite production and the angular distribution parameter of the fluorescence radiation were measured by photon-induced fluorescence spectroscopy after excitationx with linearly polarized monochromatized synchrotron radiation at exciting-photon energies between 28.45 eV and 29.95 eV with an exciting-photon energy resolution of 10 meV (FWHM). Measured cross sections are in good agreement with the computed ones. A refined assignment of resonances in the proximity of the 4s 1 4p 6 5p resonance was performed. It was concluded that there is a strong influence of the core rearrangement, of the interaction between resonances through the autoionization continua and of the interaction between autoionization continua, on the investigated processes on the basis of the observed good overall agreement between the computed and measured quantities

  2. Auxin-dependent microtubule responses and seedling development are affected in a rice mutant resistant to EPC

    International Nuclear Information System (INIS)

    Nick, P.; Yatou, O.; Furuya, M.; Lambert, A.M.

    1994-01-01

    Mutants in rice (Oryza sativa L. cv. japonica) were used to study the role of the cytoskeleton in signal-dependent morphogenesis. Mutants obtained by gamma ray irradiation were selected that failed to show inhibition of coleoptile elongation by the anti microtubular drug ethyl-N-phenylcarbamate (EPC). The mutation EPC-Resistant 31 (ER31), isolated from such a screen, caused lethality in putatively homozygous embryos. Heterozygotes exhibited drug resistance, impaired development of crown roots, and characteristic changes in the pattern of cell elongation: cell elongation was enhanced in mesocotyls and leaf sheaths, but inhibited in coleoptiles. The orientation of cortical microtubules changed correspondingly: for etiolated seedlings, compared with the wild-type, they were more transverse with respect to the long cell axis in mesocotyls and leaf sheaths, but more longitudinal in coleoptiles. In mutant coleoptiles, in contrast to wild-type, microtubules did not reorient in response to auxin, and their response to microtubule-eliminating and microtubule-stabilizing drugs was conspicuously reduced. In contrast, they responded normally to other stimuli such as gibberellins or red light. Auxin sensitivity as assayed by the dose-response for callus induction did not show any significant differences between wild-type and mutant. The mutant phenotype is interpreted in terms of an interrupted link between auxin-triggered signal transduction and microtubule reorientation. (author)

  3. Análisis de programas de mejora continua. Un estudio longitudinal en una empresa industrial Estudo longitudinal dos resultados da melhora continua em uma empresa industrial

    Directory of Open Access Journals (Sweden)

    Juan A. Marin-Garcia

    2008-12-01

    Full Text Available Las empresas han utilizado diversas herramientas que permiten que los operarios contribuyan al proceso de mejora continua. Entre las herramientas más usadas podemos destacar los sistemas de sugerencias tanto individuales como en grupo. En esta comunicación haremos un repaso de las principales características de ambos sistemas y los modos habituales de implantación. Nuestra ponencia pretende intentar responder a estas preguntas de investigación. ¿Qué resultados se derivan de la implantación de sistemas de sugerencias individuales o en grupo? ¿Cuál de los dos sistemas es más beneficioso para la empresa? ¿Qué problemas surgen durante el funcionamiento de estos programas? Para ello, analizaremos los datos de un caso de empresa industrial donde hemos recogido los datos históricos de 5 años de aplicación de un programa de mejora continua. Ambos programas han demostrado ser provechosos para la empresa, aunque las posibilidades de los sistemas de grupo parecen ser significativamente mayores.As empresas tem utilizado diversas ferramentas que permitem que os operarios comtribuam ao processo de melhora continua. Entre as ferramentas mas usadas podemos destacar os sistemas de sugestoes tanto individual como em grupo. Nesta comunicação faremos um repaso das principais caracteristicas de ambos sistemas e os modos habituais de implantação. Nossa comunicação pretende responder a estas perguntas de pesquisa. Que resultados derivam da implantaçao de sistemas de sugestoes individuais ou em grupo? Qual dos dois sistemas beneficia mais a empresa? Que problemas surgem durante o funcionamento destes programas? Para isso analisaremos os dados de um caso de empresa industrial, onde tiramos os dados historicos de 5 anos de aplicação de um programa melhora continua. Ambos programas demonstraram ser aproveitados para a empresa, ainda que as possibilidades dos sistemas de grupo se mostram significativamente maiores.

  4. Genotoxic Potential of Two Herbicides and their Active Ingredients Assessed with Comet Assay on a Fish Cell Line, Epithelioma Papillosum Cyprini (EPC)

    DEFF Research Database (Denmark)

    Syberg, Kristian; Rank, Jette; Jensen, Klara

    2013-01-01

    The aim of this study was to optimize the epithelioma papillosum cyprini (EPC) cell line handling procedure for the comet assay to investigate the genotoxic potential of widely used pesticides. The effects of various media and handling of the EPC cell line were examined. Results indicated......-(2,4-dichlorophenoxy)propionic acid) individually and in a ternary mixture were examined with the comet assay. Data showed that among the active ingredients only 2,4-D andMCPA induced DNA damage, while both herbicides were genotoxic at high concentrations....

  5. Benefits through Utilising EPC Network Components in Service‐Oriented Environments – an Analysis Using the Example of the Food Industry

    Directory of Open Access Journals (Sweden)

    Ralph Tröger

    2014-03-01

    Full Text Available Improvements in the food sector imply enhancements of delivering food which is safe, affordable, readily available, and of the quality and diversity consumers expect. However, prevalent information systems (IS of companies in the food industry are not ready to support further significant improvements. They especially lack the capability to exchange relevant information in an efficient manner. Since recently, two major developments can be observed from IS perspective: the spreading of service-oriented architectures (SOA as well as an increase in mass serialization (due to public and private traceability requirements, e.g.. So far, though most important due to food safety, a growing need to become more efficient as well as an increasing information demand of consumers, the food sector has attracted little attention in literature concerning an analysis about the potential of both service-orientation and the Electronic Product Code (EPC Network. This is why this paper will investigate to which extent these two developments can contribute to facilitate food companies’ IS helping them to maintain their competiveness. As a starting point, the research paper will depict the state of the art including SOA and the EPC Network. After describing the research approach, it will proceed with a characterisation of the food sector including an examination why there is need for action. Based on current research findings as well as experience gathered in recent projects, the paper will investigate the application of the EPC Network with its three major components, i. e. EPCIS (EPC Information Services, ONS (Object Name Service and the EPC Discovery Services, as part of future IS architectures in this sector. The paper will close with a discussion whether the envisioned IS architecture is appropriate to accomplish the previously identified challenges and requirements in the food sector in a more agile, efficient and effective way. What is more, it will highlight

  6. FORMACIÓN CONTINUA: ¿HACIA DÓNDE VAMOS?

    OpenAIRE

    Macazana Fernandez, Dante Manuel

    2014-01-01

    En nuestros contextos, la formación continua de los docentes es prioritaria para responder a las necesidades de mejora de la calidad de la educación. En esta perspectiva; a pesar de los condicionamientos de carácter socioeconómico que ha creado la aplicación del neoliberalismo en nuestro país; se plantea como prioridad buscar con una nueva visión el desarrollo social, cultural y económico, a partir de las reflexiones, consensos y redefiniciones de la profesión docente y su función social, y e...

  7. Finite-life fatigue constraints in 2D topology optimization of continua

    DEFF Research Database (Denmark)

    Oest, Jacob; Lund, Erik

    2017-01-01

    of fatigue damage are estimated using the stress-based Sines fatigue criterion and S − N curves, while the accumulated damage is estimated using Palmgren-Miner’s rule. The method is a natural extension of classical density-based topology optimization with static stress constraints, and thus utilizes many......Topology optimization of 2D continua with the objective of minimizing the mass while considering finite-life fatigue constraint is considered. The structure is subjected to proportional variable-amplitude loading. The topology optimization problem is solved using the density approach. The fractions...

  8. Nonlinear mechanics a supplement to theoretical mechanics of particles and continua

    CERN Document Server

    Fetter, Alexander L

    2006-01-01

    In their prior Dover book, Theoretical Mechanics of Particles and Continua, Alexander L. Fetter and John Dirk Walecka provided a lucid and self-contained account of classical mechanics, together with appropriate mathematical methods. This supplement-an update of that volume-offers a bridge to contemporary mechanics.The original book's focus on continuum mechanics-with chapters on sound waves in fluids, surface waves on fluids, heat conduction, and viscous fluids-forms the basis for this supplement's discussion of nonlinear continuous systems. Topics include linearized stability analysis; a det

  9. Una alternativa de autogestión de los centros de educación continua

    OpenAIRE

    José Luís Flores Galavíz; J. Jesús Ceja Pizano; Israel Patiño Galván

    2013-01-01

    La educación continua y a distancia es un mecanismo “ad-hoc” que impulsa a los particulares y a las universidades aún públicas a hacerse de recursos extraordinarios y a auto gestionar su función en el sistema educativo mundial, bajo programas respaldados sobre todo por los Organismos Multinacionales sociales y financieros como a la UNESCO y el Banco Mundial respectivamente, que promueven en la actualidad su adopción en todo el mundo y para el caso de México, esta forma de impartir actualizaci...

  10. Evaluación continua y autoevaluación como herramientas de aprendizaje

    OpenAIRE

    Zubcoff Vallejo, José Jacobo

    2014-01-01

    En el contexto actual, en los planes de estudio de los grados se incluye la evaluación continua como parte fundamental de la evaluación. En este trabajo se resumen las principales conclusiones y aspectos destacados del debate de los trabajos presentados en la mesa 12 de comunicaciones orales de las Jornadas de Redes de Investigación en Docencia Universitaria desarrollada en la Universidad de Alicante durante los días 3 y 4 de Julio de 2014. Entre las herramientas que han mostrado resultados p...

  11. Symmetry aspects of multipole moments in electromagnetism and mechanics of continua

    International Nuclear Information System (INIS)

    Baleanu, D.; Dubovik, V.M.; Misiku, S.

    1998-01-01

    We investigate the form of some multipole tensors, which arise in the expansion of a system of charges and currents, in terms of second-order Killing-Yano tensors in the phase space of classical mechanics. We related some of these tensors to the generators of dynamical symmetries like the angular momentum, the mass-inertia tensor, the conformal operator and the momentum conjugate Runge-Lenz vector. In this way we associate a geometrical meaning to such physical observables of the continua

  12. The use of area-oriented work breakdown structures in developments of EPC of process unit; Emprego de estruturas analiticas de projeto orientadas por area fisica em empreendimentos EPC (Engineering, Procurement and Construction) de unidade de processo

    Energy Technology Data Exchange (ETDEWEB)

    Salloum, Joao; Balbi, Diego J.G. [Promon Engenharia Ltda., Rio de Janeiro, RJ (Brazil)

    2012-07-01

    The use of area-oriented work breakdown structures has been proven as a very useful tool for supporting the 'scope detailing' processes in construction projects. This practice allows the definition of intermediate work packages, assisting in the distribution of the scope to be executed within the different team members (or subcontractors), and also allowing the definition of a basic construction strategy based on the main project constraints reflected in each physical area (delivery lead-time of long lead items, for example), to be used as a guide for developing a preliminary master schedule for engineering e procurement activities with a better alignment with the construction strategy. In this way the detailed engineering activities can be developed based on this structure allowing, for example, the possibility of issue piping isometrics and plants under this structure. It's common to split the scope according to the physical location on the eve of starting the field activities as a way to identify the workfaces at the time of the development of 'execution plans' for field activities. However, since this stage much of the engineering activities are already in progress, or even completed, the likelihood of conflicting strategies, such as choosing to start the installation of piping in areas that do not have availability of design documents or required material is considerably higher. Therefore, this study has the intention to discuss about the use of this practice in the early stages of the detailed engineering phase and show the practical impacts of the application of this concept, showing the results obtained with this strategy in oil refining process plant EPC project carried out by Promon Engineering. (author)

  13. Validation of an extraction paper chromatography (EPC) technique for estimation of trace levels of 90Sr in 90Y solutions obtained from 90Sr/90Y generator systems

    International Nuclear Information System (INIS)

    Usha Pandey; Yogendra Kumar; Ashutosh Dash

    2014-01-01

    While the extraction paper chromatography (EPC) technique constitutes a novel paradigm for the determination of few Becquerels of 90 Sr in MBq quantities of 90 Y obtained from 90 Sr/ 90 Y generator, validation of the technique is essential to ensure its usefulness as a real time analytical tool. With a view to explore the relevance and applicability of EPC technique as a real time quality control (QC) technique for the routine estimation of 90 Sr content in generator produced 90 Y, a systematic validation study was carried out diligently not only to establish its worthiness but also to broaden its horizon. The ability of the EPC technique to separate trace amounts of Sr 2+ in the presence of large amounts of Y 3+ was verified. The specificity of the technique for Y 3+ was demonstrated with 90 Y obtained by neutron irradiation. The method was validated under real experimental conditions and compared with a QC method described in US Pharmacopeia for detection of 90 Sr levels in 90 Y radiopharmaceuticals. (author)

  14. Molecular interactions of CPC, CPB, CTAB, and EPC biosurfactants in aqueous olive oil mixtures analyzed with physicochemical data and SEM micrographs

    Directory of Open Access Journals (Sweden)

    Man Singh

    2014-12-01

    Full Text Available Structural studies of olive oil–water–biosurfactants mixtures are most attracting for several academic as well as industrial significances. Thus, densities (ρ, viscosities (η, and surface tensions (γ of cetylpyridinium chloride (CPC and bromide (CPB, cetyltrimethylammonium bromide (CTAB and egg-phosphatidylcholine (EPC biosurfactants (BS 2–10 mm kg−1 in olive oil + water mixture in 2 mm kg−1 interval at 310.15 K are reported. The densities were for apparent molal volume (Vϕ/10−6 m3 mol−1, η and γ determinations. The viscosities were fitted in extended Jones–Doles equation for intrinsic viscosity (B, kg mol−1 and slope (D, kg mol−12 derivation. The γ and Vϕ data were regressed for their limiting γ0 andVϕ0 data and the SEMs were illustrated surface morphology. The EPC caused maximum oil–water dissolution as compared to other surfactants. Intramolecular multiple force theory [IMMFT] is proposed to explain molecular interactions of olive oil–water–EPC mixtures with a possible correlation of surface and bulk reorientations with microstructures depicted with SEM. Frictional and cohesive forces as Friccohesity have been noted as driving forces to assert for validity of the IMMFT model and its link with SEM.

  15. Educación permanente y continua en una perspectiva de integridad del ser

    Directory of Open Access Journals (Sweden)

    Izabel Cristina Feijó de Andrade

    2014-12-01

    Full Text Available Este artículo buscó discutir las articulaciones y distinciones entre los conceptos de educación permanente y educación continua de modo que favorezca la perspectiva de integridad del ser, vínculo que requiere saberes hasta entonces poco privilegiados en las Universidades y que demandan el rescate de dimensiones basadas en la experiencia, la didáctica y la existencia del educador, tanto individual, comportamental, cultural, social y espiritual. Consideramos que las nociones de educación permanente y educación continua poseen elementos entrelazables que nos permiten desarrollar la capacidad de reaccionar críticamente por medio de una relación autoformativa. Las revisiones teóricas implementadas permitieron algunas consideraciones sobre los procesos formativos actuales y las prácticas de profesores rumbo a una Educación para la Integridad. Concluimos provisoriamente que las aproximaciones y distinciones entre EP y EC pueden proporcionar a los profesores la toma de conciencia de su vinculación todo/parte y del sentido de la vida.

  16. Design of a Real-Time and Continua-Based Framework for Care Guideline Recommendations

    Directory of Open Access Journals (Sweden)

    Yu-Feng Lin

    2014-04-01

    Full Text Available Telehealth is an important issue in the medical and healthcare domains. Although a number of systems have been developed to meet the demands of emerging telehealth services, the following problems still remain to be addressed: (1 most systems do not monitor/predict the vital signs states so that they are able to send alarms to caregivers in real-time; (2 most systems do not focus on reducing the amount of work that caregivers need to do, and provide patients with remote care; and (3 most systems do not recommend guidelines for caregivers. This study thus proposes a framework for a real-time and Continua-based Care Guideline Recommendation System (Cagurs which utilizes mobile device platforms to provide caregivers of chronic patients with real-time care guideline recommendations, and that enables vital signs data to be transmitted between different devices automatically, using the Continua standard. Moreover, the proposed system adopts the episode mining approach to monitor/predict anomalous conditions of patients, and then offers related recommended care guidelines to caregivers so that they can offer preventive care in a timely manner.

  17. Modulación Vectorial de Inversores Multinivel con Diodos de Enclavamiento con Balance del Bus de Continua

    Directory of Open Access Journals (Sweden)

    Santiago A. Verne

    2009-04-01

    Full Text Available Resumen: En este trabajo se presenta un algoritmo de modulación para convertidores multinivel de enclavamiento por diodos que optimiza el balance del bus de continua. Se describe el mecanismo de modulación vectorial para convertidores multinivel y se desarrolla un método que permite mantener equilibradas las tensiones del bus de continua utilizando la redundancia del convertidor. El presente algoritmo puede aplicarse a convertidores con un número arbitrario de niveles. Se consideran en el desarrollo dos situaciones prácticas: presencia o ausencia de una fuente de tensión continua sobre el bus. El desempeño del modulador es estudiado mediante simulaciones digitales. Palabras clave: convertidores multinivel, modulación, vector espacial

  18. Arquitectura de Auditoría continua para el Control Fiscal Colombiano. Una versión preliminar

    OpenAIRE

    Valencia Duque, Francisco Javier

    2013-01-01

    La auditoría continua es una modalidad de auditoría, y como tal, contempla las diferentes fases del ciclo general de auditoría, teniendo en cuenta que los resultados de un proceso de auditoría continua "se integran al proceso de auditoría en todos sus aspectos, desde el desarrollo y mantenimiento del plan de auditoría empresarial, hasta la realización y el seguimiento de auditorías específicas" (Coderre, 2005,1)

  19. Metodología para seleccionar oportunidades de mejora continua en promociones de viviendas

    Directory of Open Access Journals (Sweden)

    Del Solar, P.

    2015-06-01

    Full Text Available Continuous improvement should always be present in business, have they or not management systems on hand according to the UNE EN ISO 9001:2008 Standard. However, its application in the construction sector is especially hard due to the particular characteristics of this business (1. This paper focuses on how to apply four of the seven basic statistical continuous improvement tools (Data collection sheet, Stratification, Histogram and Pareto Diagram in order to select improvement opportunities within the planification phase of a continuous improvement project whose aims is the reduction of the construction failures in housing blocks which would be detected during the pre-delivery phase. The conclusion is that the three works in which it would be convenient to act in order to reduce significantly the construction failures during the pre-delivery phase are: Wood Carpentry, Ceramic Tile and Electricity.La mejora continua debería estar presente siempre en las empresas, dispongan o no de sistemas de gestión conforme a la Norma UNE EN ISO 9001:2008. Sin embargo, su aplicación en el sector de la construcción es especialmente difícil debido a las características particulares del mismo (1. Este articulo describe cómo aplicar cuatro de las siete herramientas estadísticas básicas de la mejora continua (Hoja de recogida de datos, Estratificación, Histograma y Diagrama de Pareto para seleccionar oportunidades de mejora, dentro de la fase de planificación de un proyecto de mejora continua que tenga como objetivo reducir los defectos de construcción en edificios de viviendas detectados en la fase de pre-entrega. Concluyendo que los tres oficios en los que convendría actuar para reducir de manera significativa los fallos de construcción en la fase de pre-entrega son: Carpintería de Madera, Revestimientos Cerámicos e Instalación de Electricidad.

  20. Electrostatics of proteins in dielectric solvent continua. I. An accurate and efficient reaction field description.

    Science.gov (United States)

    Bauer, Sebastian; Mathias, Gerald; Tavan, Paul

    2014-03-14

    We present a reaction field (RF) method which accurately solves the Poisson equation for proteins embedded in dielectric solvent continua at a computational effort comparable to that of an electrostatics calculation with polarizable molecular mechanics (MM) force fields. The method combines an approach originally suggested by Egwolf and Tavan [J. Chem. Phys. 118, 2039 (2003)] with concepts generalizing the Born solution [Z. Phys. 1, 45 (1920)] for a solvated ion. First, we derive an exact representation according to which the sources of the RF potential and energy are inducible atomic anti-polarization densities and atomic shielding charge distributions. Modeling these atomic densities by Gaussians leads to an approximate representation. Here, the strengths of the Gaussian shielding charge distributions are directly given in terms of the static partial charges as defined, e.g., by standard MM force fields for the various atom types, whereas the strengths of the Gaussian anti-polarization densities are calculated by a self-consistency iteration. The atomic volumes are also described by Gaussians. To account for covalently overlapping atoms, their effective volumes are calculated by another self-consistency procedure, which guarantees that the dielectric function ε(r) is close to one everywhere inside the protein. The Gaussian widths σ(i) of the atoms i are parameters of the RF approximation. The remarkable accuracy of the method is demonstrated by comparison with Kirkwood's analytical solution for a spherical protein [J. Chem. Phys. 2, 351 (1934)] and with computationally expensive grid-based numerical solutions for simple model systems in dielectric continua including a di-peptide (Ac-Ala-NHMe) as modeled by a standard MM force field. The latter example shows how weakly the RF conformational free energy landscape depends on the parameters σ(i). A summarizing discussion highlights the achievements of the new theory and of its approximate solution particularly by

  1. Electrostatics of proteins in dielectric solvent continua. I. An accurate and efficient reaction field description

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Sebastian; Mathias, Gerald; Tavan, Paul, E-mail: paul.tavan@physik.uni-muenchen.de [Lehrstuhl für BioMolekulare Optik, Ludwig–Maximilians Universität München, Oettingenstr. 67, 80538 München (Germany)

    2014-03-14

    We present a reaction field (RF) method which accurately solves the Poisson equation for proteins embedded in dielectric solvent continua at a computational effort comparable to that of an electrostatics calculation with polarizable molecular mechanics (MM) force fields. The method combines an approach originally suggested by Egwolf and Tavan [J. Chem. Phys. 118, 2039 (2003)] with concepts generalizing the Born solution [Z. Phys. 1, 45 (1920)] for a solvated ion. First, we derive an exact representation according to which the sources of the RF potential and energy are inducible atomic anti-polarization densities and atomic shielding charge distributions. Modeling these atomic densities by Gaussians leads to an approximate representation. Here, the strengths of the Gaussian shielding charge distributions are directly given in terms of the static partial charges as defined, e.g., by standard MM force fields for the various atom types, whereas the strengths of the Gaussian anti-polarization densities are calculated by a self-consistency iteration. The atomic volumes are also described by Gaussians. To account for covalently overlapping atoms, their effective volumes are calculated by another self-consistency procedure, which guarantees that the dielectric function ε(r) is close to one everywhere inside the protein. The Gaussian widths σ{sub i} of the atoms i are parameters of the RF approximation. The remarkable accuracy of the method is demonstrated by comparison with Kirkwood's analytical solution for a spherical protein [J. Chem. Phys. 2, 351 (1934)] and with computationally expensive grid-based numerical solutions for simple model systems in dielectric continua including a di-peptide (Ac-Ala-NHMe) as modeled by a standard MM force field. The latter example shows how weakly the RF conformational free energy landscape depends on the parameters σ{sub i}. A summarizing discussion highlights the achievements of the new theory and of its approximate solution

  2. Modeling reactive transport in deformable porous media using the theory of interacting continua.

    Energy Technology Data Exchange (ETDEWEB)

    Turner, Daniel Zack

    2012-01-01

    This report gives an overview of the work done as part of an Early Career LDRD aimed at modeling flow induced damage of materials involving chemical reactions, deformation of the porous matrix, and complex flow phenomena. The numerical formulation is motivated by a mixture theory or theory of interacting continua type approach to coupling the behavior of the fluid and the porous matrix. Results for the proposed method are presented for several engineering problems of interest including carbon dioxide sequestration, hydraulic fracturing, and energetic materials applications. This work is intended to create a general framework for flow induced damage that can be further developed in each of the particular areas addressed below. The results show both convincing proof of the methodologies potential and the need for further validation of the models developed.

  3. Quasi-stationary mechanics of elastic continua with bending stiffness wrapping on a pulley system

    Science.gov (United States)

    Kaczmarczyk, S.; Mirhadizadeh, S.

    2016-05-01

    In many engineering applications elastic continua such as ropes and belts often are subject to bending when they pass over pulleys / sheaves. In this paper the quasi-stationary mechanics of a cable-pulley system is studied. The cable is modelled as a moving Euler- Bernoulli beam. The distribution of tension is non-uniform along its span and due to the bending stiffness the contact points at the pulley-beam boundaries are not unknown. The system is described by a set of nonlinear ordinary differential equations with undetermined boundary conditions. The resulting nonlinear Boundary Value Problem (BVP) with unknown boundaries is solved by converting the problem into the ‘standard’ form defined over a fixed interval. Numerical results obtained for a range of typical configurations with relevant boundary conditions applied demonstrate that due to the effects of bending stiffness the angels of wrap are reduced and the span tensions are increased.

  4. Applicability of IHE/Continua components for PHR systems: learning from experiences.

    Science.gov (United States)

    Urbauer, Philipp; Sauermann, Stefan; Frohner, Matthias; Forjan, Mathias; Pohn, Birgit; Mense, Alexander

    2015-04-01

    Capturing personal health data using smartphones, PCs or other devices, and the reuse of the data in personal health records (PHR) is becoming more and more attractive for modern health-conscious populations. This paper analyses interoperability specifications targeting standards-based communication of computer systems and personal health devices (e.g. blood pressure monitor) in healthcare from initiatives like Integrating the Healthcare Enterprise (IHE) and Continua Health Alliance driven by industry and healthcare professionals. Furthermore it identifies certain contradictions and gaps in the specifications and suggests possible solutions. Despite these shortcomings, the specifications allow fully functional implementations of PHR systems. Henceforth, both big business and small and medium-sized enterprises (SMEs) can actively contribute to the widespread use of large-scale interoperable PHR systems. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Nivel de desempeño en manufactura esbelta, manufactura sustentable y mejora continua

    Directory of Open Access Journals (Sweden)

    Carlos Monge

    2016-02-01

    Full Text Available 40 plantas de manufactura medianas (12 y grandes (28 de Apodaca, México, fueron encuestadas para investigar el nivel de implantación de la manufactura esbelta, la manufactura sustentable, la mejora continua y su impacto en la eficiencia operacional y responsabilidad ambiental en ellas. En las dos categorías de plantas se encontró que el desempeño es bajo. En ambos casos es preocupante que en el municipio altamente industrializado de Apodaca, México, no se estén adoptando de manera decisiva las filosofías mencionadas. Finalmente se muestran los resultados estadísticos obtenidos en las respuestas de los gerentes de planta a los ítems del cuestionario. Esta información puede ser útil a la administración de las plantas para identificar y definir acciones específicas de mejora.

  6. On the mechanics of continua with boundary energies and growing surfaces

    Science.gov (United States)

    Papastavrou, Areti; Steinmann, Paul; Kuhl, Ellen

    2013-06-01

    Many biological systems are coated by thin films for protection, selective absorption, or transmembrane transport. A typical example is the mucous membrane covering the airways, the esophagus, and the intestine. Biological surfaces typically display a distinct mechanical behavior from the bulk; in particular, they may grow at different rates. Growth, morphological instabilities, and buckling of biological surfaces have been studied intensely by approximating the surface as a layer of finite thickness; however, growth has never been attributed to the surface itself. Here, we establish a theory of continua with boundary energies and growing surfaces of zero thickness in which the surface is equipped with its own potential energy and is allowed to grow independently of the bulk. In complete analogy to the kinematic equations, the balance equations, and the constitutive equations of a growing solid body, we derive the governing equations for a growing surface. We illustrate their spatial discretization using the finite element method, and discuss their consistent algorithmic linearization. To demonstrate the conceptual differences between volume and surface growth, we simulate the constrained growth of the inner layer of a cylindrical tube. Our novel approach toward continua with growing surfaces is capable of predicting extreme growth of the inner cylindrical surface, which more than doubles its initial area. The underlying algorithmic framework is robust and stable; it allows to predict morphological changes due to surface growth during the onset of buckling and beyond. The modeling of surface growth has immediate biomedical applications in the diagnosis and treatment of asthma, gastritis, obstructive sleep apnoea, and tumor invasion. Beyond biomedical applications, the scientific understanding of growth-induced morphological instabilities and surface wrinkling has important implications in material sciences, manufacturing, and microfabrication, with applications in

  7. Proposal of a critical test of the Navier-Stokes-Fourier paradigm for compressible fluid continua

    Science.gov (United States)

    Brenner, Howard

    2013-01-01

    A critical, albeit simple experimental and/or molecular-dynamic (MD) simulation test is proposed whose outcome would, in principle, establish the viability of the Navier-Stokes-Fourier (NSF) equations for compressible fluid continua. The latter equation set, despite its longevity as constituting the fundamental paradigm of continuum fluid mechanics, has recently been criticized on the basis of its failure to properly incorporate volume transport phenomena—as embodied in the proposed bivelocity paradigm [H. Brenner, Int. J. Eng. Sci.IJESAN0020-722510.1016/j.ijengsci.2012.01.006 54, 67 (2012)]—into its formulation. Were the experimental or simulation results found to accord, even only qualitatively, with bivelocity predictions, the temperature distribution in a gas-filled, thermodynamically and mechanically isolated circular cylinder undergoing steady rigid-body rotation in an inertial reference frame would not be uniform; rather, the temperature would be higher at the cylinder wall than along the axis of rotation. This radial temperature nonuniformity contrasts with the uniformity of the temperature predicted by the NSF paradigm for these same circumstances. Easily attainable rates of rotation in centrifuges and readily available tools for measuring the expected temperature differences render experimental execution of the proposed scheme straightforward in principle. As such, measurement—via experiment or MD simulation—of, say, the temperature difference ΔT between the gas at the wall and along the axis of rotation would provide quantitative tests of both the NSF and bivelocity hydrodynamic models, whose respective solutions for the stated set of circumstances are derived in this paper. Independently of the correctness of the bivelocity model, any temperature difference observed during the proposed experiment or simulation, irrespective of magnitude, would preclude the possibility of the NSF paradigm being correct for fluid continua, except for

  8. PREFACE: The 7th International Seminar on Geometry, Continua and Microstructures

    Science.gov (United States)

    Burton, David A.

    2007-04-01

    It gives me great pleasure to present the proceedings of the 7th International Seminar on Geometry, Continua and Microstructures (GCM 7). The conference took place on 25-27 September 2006 at Lancaster University and the local organisers were Robin Tucker, Tim Walton, myself and Jonathan Gratus of the Lancaster University Mathematical Physics Group. Modern field theories of mechanically and electrically responsive continua have a wealth of interesting applications in physics. Such theories provide effective macroscopic models of complex systems, such as living tissue and material with dynamical defects, that capture macroscopic consequences of microscopic phenomena. GCM is an interdisciplinary conference series, initiated by the Eringen medallist Gérard A Maugin, that brings together physicists and applied mathematicians who have interests in continuum mechanics and differential geometry and who aim to develop new and powerful methods for analysing the behaviour of complex mechanical systems. The earlier conferences in the series were held in Paris, Madrid, Mannheim, Turin, Sinaia and Belgrade. This volume addresses a variety of topics including the physics of saturated porous media, the relationship between growth in living tissue and molecular transport, the mechanics of polymer bonds, the macroscopic properties of damaged elastomers, the mechanics of carbon nanotubes, the geometry of balance systems in Continuum Thermodynamics and wave propagation in the material manifold. I would like to warmly thank the rest of the organising committee and the conference participants for making GCM 7 an enjoyable and rewarding occasion. Photographs may be found at http://www.lancs.ac.uk/depts/spc/conf/gcm7/wss/index.htm David A Burton Editor

  9. Proposal of a critical test of the Navier-Stokes-Fourier paradigm for compressible fluid continua.

    Science.gov (United States)

    Brenner, Howard

    2013-01-01

    A critical, albeit simple experimental and/or molecular-dynamic (MD) simulation test is proposed whose outcome would, in principle, establish the viability of the Navier-Stokes-Fourier (NSF) equations for compressible fluid continua. The latter equation set, despite its longevity as constituting the fundamental paradigm of continuum fluid mechanics, has recently been criticized on the basis of its failure to properly incorporate volume transport phenomena-as embodied in the proposed bivelocity paradigm [H. Brenner, Int. J. Eng. Sci. 54, 67 (2012)]-into its formulation. Were the experimental or simulation results found to accord, even only qualitatively, with bivelocity predictions, the temperature distribution in a gas-filled, thermodynamically and mechanically isolated circular cylinder undergoing steady rigid-body rotation in an inertial reference frame would not be uniform; rather, the temperature would be higher at the cylinder wall than along the axis of rotation. This radial temperature nonuniformity contrasts with the uniformity of the temperature predicted by the NSF paradigm for these same circumstances. Easily attainable rates of rotation in centrifuges and readily available tools for measuring the expected temperature differences render experimental execution of the proposed scheme straightforward in principle. As such, measurement-via experiment or MD simulation-of, say, the temperature difference ΔT between the gas at the wall and along the axis of rotation would provide quantitative tests of both the NSF and bivelocity hydrodynamic models, whose respective solutions for the stated set of circumstances are derived in this paper. Independently of the correctness of the bivelocity model, any temperature difference observed during the proposed experiment or simulation, irrespective of magnitude, would preclude the possibility of the NSF paradigm being correct for fluid continua, except for incompressible flows.

  10. Status and methodology of publicly available national HIV care continua and 90-90-90 targets: A systematic review.

    Directory of Open Access Journals (Sweden)

    Reuben Granich

    2017-04-01

    Full Text Available In 2014, the Joint United Nations Program on HIV/AIDS (UNAIDS issued treatment goals for human immunodeficiency virus (HIV. The 90-90-90 target specifies that by 2020, 90% of individuals living with HIV will know their HIV status, 90% of people with diagnosed HIV infection will receive antiretroviral treatment (ART, and 90% of those taking ART will be virally suppressed. Consistent methods and routine reporting in the public domain will be necessary for tracking progress towards the 90-90-90 target.For the period 2010-2016, we searched PubMed, UNAIDS country progress reports, World Health Organization (WHO, UNAIDS reports, national surveillance and program reports, United States President's Emergency Plan for AIDS Relief (PEPFAR Country Operational Plans, and conference presentations and/or abstracts for the latest available national HIV care continuum in the public domain. Continua of care included the number and proportion of people living with HIV (PLHIV who are diagnosed, on ART, and virally suppressed out of the estimated number of PLHIV. We ranked the described methods for indicators to derive high-, medium-, and low-quality continuum. For 2010-2016, we identified 53 national care continua with viral suppression estimates representing 19.7 million (54% of the 2015 global estimate of PLHIV. Of the 53, 6 (with 2% of global burden were high quality, using standard surveillance methods to derive an overall denominator and program data from national cohorts for estimating steps in the continuum. Only nine countries in sub-Saharan Africa had care continua with viral suppression estimates. Of the 53 countries, the average proportion of the aggregate of PLHIV from all countries on ART was 48%, and the proportion of PLHIV who were virally suppressed was 40%. Seven countries (Sweden, Cambodia, United Kingdom, Switzerland, Denmark, Rwanda, and Namibia were within 12% and 10% of achieving the 90-90-90 target for "on ART" and for "viral suppression

  11. Effect of granulocyte colony stimulating EPC on cardiac function and myocardial energy expenditure in patients with heart failure after myocardial infarction.

    Science.gov (United States)

    Zhao, Zilin; Luo, Jianchun; Ma, Lixian; Luo, Xia; Huang, Liangyan

    2015-01-01

    To study the changes of cardiac function and myocardial energy expenditure following treatment with granulocyte colony stimulating factor (G-CSF) in patients with heart failure after myocardial infarction. Thirty-eight patients with heart failure after myocardial infarction were randomized into G-CSF treatment group and control group. All the patients received conventional treatment (medication and interventional therapy), and the patients in treatment group were given additional G-CSF (600 μg/day) for 7 consecutive days. The plasma level of brain-type natriuretic peptide (BNP) and the number of endothelial progenitor cells (EPC) in the peripheral blood were detected before and at 7 days and 4 months after the treatment. The cardiac functions (LVEF, FS, LVIDs, PWTs, EDV, SV, ET) was evaluated by ultrasonic imaging before and at 2 weeks and 4 months after the treatment. The MEE and circumferential end-systolic wall stress (cESS) were calculated by correlation formula. The number of EPC was significantly higher in the treatment group than in the control group after the treatment especially at 7 days (Pexpenditure were improved in all the patients at 2 weeks and 4 months after the treatment, and the improvement was more obvious in the treatment group (Pexpenditure in patients with heart failure after myocardial infarction.

  12. Diagnostic and therapeutic errors in trigeminal autonomic cephalalgias and hemicrania continua: a systematic review

    Science.gov (United States)

    2013-01-01

    Trigeminal autonomic cephalalgias (TACs) and hemicrania continua (HC) are relatively rare but clinically rather well-defined primary headaches. Despite the existence of clear-cut diagnostic criteria (The International Classification of Headache Disorders, 2nd edition - ICHD-II) and several therapeutic guidelines, errors in workup and treatment of these conditions are frequent in clinical practice. We set out to review all available published data on mismanagement of TACs and HC patients in order to understand and avoid its causes. The search strategy identified 22 published studies. The most frequent errors described in the management of patients with TACs and HC are: referral to wrong type of specialist, diagnostic delay, misdiagnosis, and the use of treatments without overt indication. Migraine with and without aura, trigeminal neuralgia, sinus infection, dental pain and temporomandibular dysfunction are the disorders most frequently overdiagnosed. Even when the clinical picture is clear-cut, TACs and HC are frequently not recognized and/or mistaken for other disorders, not only by general physicians, dentists and ENT surgeons, but also by neurologists and headache specialists. This seems to be due to limited knowledge of the specific characteristics and variants of these disorders, and it results in the unnecessary prescription of ineffective and sometimes invasive treatments which may have negative consequences for patients. Greater knowledge of and education about these disorders, among both primary care physicians and headache specialists, might contribute to improving the quality of life of TACs and HC patients. PMID:23565739

  13. Quantitative spectroscopy of X-ray lines and continua in tokamaks

    International Nuclear Information System (INIS)

    Peacock, N.J.; Lawson, K.D.; Patel, A.; Barnsley, R.; Melnick, I.M.; O'Mullane, M.G.; Singleton, M.A.

    1996-10-01

    Crystal and synthetic multilayer diffractors, deployed either as flat Bragg reflectors, or curved, as in the Johann configuration, are used to study the spectrum of COMPASS-D and other tokamaks in the wavelength region 1-100 A. In this paper we concentrate on the measurement of absolute photon fluxes and the derivation of volume emissivities of the lines and continua in the X-ray region. The sensitivities of these instruments to absolute photon flux have been constructed ab initio from the individual component efficiencies, including published values of the diffractor reflectivities, which have been checked or supplemented by measurements using a double-axis goniometer or from line branching ratios. For these tokamak plasmas where the elemental abundances and effective ion charge are documented, the X-ray continuum intensity itself has been used as a calibration source to derive absolute instrument sensitivity, in reasonable agreement with the ab initio method. In the COMPASS-D tokamak, changes in the effective ion charge state, Z eff , have been derived for different operating conditions, from the absolute intensity of the continuum at ∼4 A. From the irradiances of the line emission, changes in the absolute level of impurities following ''boronisation'' of the vacuum vessel have also been documented. (UK)

  14. Transferencia de calor en la colada continua de aceros. II parte. Enfriamiento secundario

    Directory of Open Access Journals (Sweden)

    Cicutti, C.

    1997-12-01

    Full Text Available Once the strand leaves the mold, the solidification of steel progresses due to the heat extracted in the secondary cooling zone of the continuous casting machine. In this zone, heat is extracted mainly by: the incidence of water from sprays, radiation to surroundings contact with rolls and run out water accumulated between rolls and strand. In this work, all these mechanisms are evaluated and, when it is possible, they are quantified. Methods which are usually employed to measure solidification profiles in the continuous casting machine are also reviewed. Finally, the incidence of secondary cooling on the quality of cast products is discussed.

    La solidificación del acero iniciada en el molde continúa en la zona de enfriamiento secundario de la máquina donde el calor es extraído, principalmente por la incidencia del agua de los rociadores, la radiación al medio ambiente, el contacto con los rodillos y el agua acumulada en ellos. En este trabajo se revisa cada uno de estos mecanismos determinando, en los casos en que es posible, valores cuantitativos de los mismos. Además, se analizan los distintos métodos empleados para medir el avance del espesor solidificado en la máquina de colada continua. Por último, se discute la incidencia del enfriamiento secundario en la calidad final de los productos colados.

  15. Transferencia de calor en la colada continua de aceros. I parte. El molde

    Directory of Open Access Journals (Sweden)

    Cicutti, C.

    1997-10-01

    Full Text Available The continuous casting mold plays the important role of receiving the liquid steel and allowing an uniform and defect free solidified skin to be developed. In this work, the different heat transfer mechanisms which are present from the liquid steel to the mold cooling water are reviewed. The effect of operating variables on heat extraction and the relationship between global and distributed heat flux are also analyzed.

    El molde de colada continua cumple la importante función de recibir el acero líquido y permitir que se desarrolle una capa solidificada uniforme y libre de defectos. En este trabajo se revisan los distintos mecanismos implicados en el proceso de transferencia de calor, desde el acero líquido hasta el agua de refrigeración del molde. Se analiza también el efecto de las distintas variables de funcionamiento en la extracción calórica producida y la relación entre el flujo global de calor y su distribución a lo largo del molde.

  16. Revisión de literatura sobre mejora continua en MIPYMEs iberoamericanas

    Directory of Open Access Journals (Sweden)

    Carmen Patricia Jiménez Terrazas

    2014-01-01

    Full Text Available Este artículo presenta una revisión sistemática cualitativa de literatura de investigacio - nes aplicadas de mejora continua en MIPYMEs iberoamericanas y busca responder las siguientes preguntas: ¿cuáles son sus características (objetivos investigados, tipo y método de investigación y poblaciones donde se realizan? y ¿cuáles son los hallazgos encontrados? Los resultados analizan catorce investigaciones aplicadas cuyos objetivos de investigación se agrupan en tres temáticas principales: sostenibilidad, productividad e implementación. El 43% de las investigaciones son cualitativas y usan los métodos de caso de estudio y entrevistas, y un 43% son de enfoque cuantitativo y utilizan mé - todos de encuesta y cuestionario. La población más estudiada fueron las empresas, con 42.8%, y el país donde más se han realizado este tipo de investigaciones es España, con 35.7%. Los hallazgos incluyen identificación de barreras y facilitadores, niveles para su sostenibilidad, herramientas y técnicas con que se implementan, algunos relacionados con la productividad y con aspectos de abandono en su implementación.

  17. Electrostatics of proteins in dielectric solvent continua. II. Hamiltonian reaction field dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Sebastian; Tavan, Paul; Mathias, Gerald, E-mail: gerald.mathias@physik.uni-muenchen.de [Lehrstuhl für BioMolekulare Optik, Ludig-Maximilians Universität München, Oettingenstr. 67, 80538 München (Germany)

    2014-03-14

    In Paper I of this work [S. Bauer, G. Mathias, and P. Tavan, J. Chem. Phys. 140, 104102 (2014)] we have presented a reaction field (RF) method, which accurately solves the Poisson equation for proteins embedded in dielectric solvent continua at a computational effort comparable to that of polarizable molecular mechanics (MM) force fields. Building upon these results, here we suggest a method for linearly scaling Hamiltonian RF/MM molecular dynamics (MD) simulations, which we call “Hamiltonian dielectric solvent” (HADES). First, we derive analytical expressions for the RF forces acting on the solute atoms. These forces properly account for all those conditions, which have to be self-consistently fulfilled by RF quantities introduced in Paper I. Next we provide details on the implementation, i.e., we show how our RF approach is combined with a fast multipole method and how the self-consistency iterations are accelerated by the use of the so-called direct inversion in the iterative subspace. Finally we demonstrate that the method and its implementation enable Hamiltonian, i.e., energy and momentum conserving HADES-MD, and compare in a sample application on Ac-Ala-NHMe the HADES-MD free energy landscape at 300 K with that obtained in Paper I by scanning of configurations and with one obtained from an explicit solvent simulation.

  18. Infusión de antibióticos continua versus intermitente para el tratamiento de las infecciones agudas graves

    Directory of Open Access Journals (Sweden)

    2014-05-01

    Conclusiones de los autores: No hubo diferencias de la mortalidad, la recurrencia de la infección, la curación clínica, la sobreinfección posterior al tratamiento ni en los resultados de seguridad al comparar las infusiones de antibióticos intravenosos continuas con las infusiones tradicionales de antibióticos intermitentes. Sin embargo, los intervalos de confianza amplios indican que no es posible descartar los efectos beneficiosos o perjudiciales de todos los resultados. Por lo tanto, las pruebas actuales no son suficientes para recomendar la adopción generalizada de la infusión de antibióticos continua en lugar de las infusiones de antibióticos intermitentes. Se necesitan ensayos aleatorios prospectivos grandes adicionales, con un informe consistente y completo de medidas de resultado clínicas, realizados con estudios simultáneos farmacocinéticos y farmacodinámicos en poblaciones especiales para determinar si la adopción de las infusiones de antibióticos continuas se justifica en circunstancias específicas.

  19. Mecanismos de desgaste en refractarios de colada continua asociados al efecto Marangoni

    Directory of Open Access Journals (Sweden)

    Brandaleze, E.

    2005-12-01

    Full Text Available Nozzle wear during continuous casting process is caused by physical and chemical reasons and also by refractory quality. A post mortem study on a sample of Al2O3 - graphite nozzle with a ZrO2 insert allows to identify the present wear mechanisms. Different cyclic stages are carried out due to recurrent changes of interfacial tension and fluid convection. When the surface tension promote the refractory wetting by the steel, graphite of the nozzle surface is lost. Then, grains of ZrO2 and of Al2O3 are dissolved by slag contact. This type of wear is associated with the Marangoni effect. Light and electronic microscopy was used to observe the refractory structure and by a cathodoluminiscence technique phases transformations under process conditions are determined.

    Las buzas sumergidas se erosionan durante el proceso de la colada continua, debido a causas físicas, químicas y a la calidad del refractario. El estudio post mortem de una buza de Al2O3 -grafito con inserto de ZrO2 permite identificar los mecanismos de desgaste presentes, que ocurren por etapas debido a cambios cíclicos de tensión interfacial y convección de fluidos. Cuando la tensión superficial favorece la mojabilidad del refractario por el acero, la buza pierde grafito de la superficie. Luego, los granos de ZrO2 y de Al2O3 se disuelven al ser mojados por la escoria. Este desgaste está asociado al efecto Marangoni. Se observa la microestructura mediante microscopía óptica y electrónica y, por catodoluminiscencia, se determinan las transformaciones de fases ocurridas en condiciones de proceso.

  20. Classification of frequency response areas in the inferior colliculus reveals continua not discrete classes.

    Science.gov (United States)

    Palmer, Alan R; Shackleton, Trevor M; Sumner, Christian J; Zobay, Oliver; Rees, Adrian

    2013-08-15

    A differential response to sound frequency is a fundamental property of auditory neurons. Frequency analysis in the cochlea gives rise to V-shaped tuning functions in auditory nerve fibres, but by the level of the inferior colliculus (IC), the midbrain nucleus of the auditory pathway, neuronal receptive fields display diverse shapes that reflect the interplay of excitation and inhibition. The origin and nature of these frequency receptive field types is still open to question. One proposed hypothesis is that the frequency response class of any given neuron in the IC is predominantly inherited from one of three major afferent pathways projecting to the IC, giving rise to three distinct receptive field classes. Here, we applied subjective classification, principal component analysis, cluster analysis, and other objective statistical measures, to a large population (2826) of frequency response areas from single neurons recorded in the IC of the anaesthetised guinea pig. Subjectively, we recognised seven frequency response classes (V-shaped, non-monotonic Vs, narrow, closed, tilt down, tilt up and double-peaked), that were represented at all frequencies. We could identify similar classes using our objective classification tools. Importantly, however, many neurons exhibited properties intermediate between these classes, and none of the objective methods used here showed evidence of discrete response classes. Thus receptive field shapes in the IC form continua rather than discrete classes, a finding consistent with the integration of afferent inputs in the generation of frequency response areas. The frequency disposition of inhibition in the response areas of some neurons suggests that across-frequency inputs originating at or below the level of the IC are involved in their generation.

  1. Joint Bayesian Estimation of Quasar Continua and the Lyα Forest Flux Probability Distribution Function

    Science.gov (United States)

    Eilers, Anna-Christina; Hennawi, Joseph F.; Lee, Khee-Gan

    2017-08-01

    We present a new Bayesian algorithm making use of Markov Chain Monte Carlo sampling that allows us to simultaneously estimate the unknown continuum level of each quasar in an ensemble of high-resolution spectra, as well as their common probability distribution function (PDF) for the transmitted Lyα forest flux. This fully automated PDF regulated continuum fitting method models the unknown quasar continuum with a linear principal component analysis (PCA) basis, with the PCA coefficients treated as nuisance parameters. The method allows one to estimate parameters governing the thermal state of the intergalactic medium (IGM), such as the slope of the temperature-density relation γ -1, while marginalizing out continuum uncertainties in a fully Bayesian way. Using realistic mock quasar spectra created from a simplified semi-numerical model of the IGM, we show that this method recovers the underlying quasar continua to a precision of ≃ 7 % and ≃ 10 % at z = 3 and z = 5, respectively. Given the number of principal component spectra, this is comparable to the underlying accuracy of the PCA model itself. Most importantly, we show that we can achieve a nearly unbiased estimate of the slope γ -1 of the IGM temperature-density relation with a precision of +/- 8.6 % at z = 3 and +/- 6.1 % at z = 5, for an ensemble of ten mock high-resolution quasar spectra. Applying this method to real quasar spectra and comparing to a more realistic IGM model from hydrodynamical simulations would enable precise measurements of the thermal and cosmological parameters governing the IGM, albeit with somewhat larger uncertainties, given the increased flexibility of the model.

  2. A chronology of the PY608E-PC sediment core (Lake Pumoyum Co, southern Tibetan Plateau) based on radiocarbon dating of total organic carbon

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Takahiro, E-mail: twatanabe@geo.kankyo.tohoku.ac.jp [Graduate School of Environmental Studies, Tohoku University, 6-6-20 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8579 (Japan); Graduate School of Science, Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8578 (Japan); Nakamura, Toshio [Center for Chronological Research, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601 (Japan); Matsunaka, Tetsuya [School of Marine Science and Technology, Tokai University, 3-20-1 Orido, Shimizu, Shizuoka 424-0902 (Japan); Nara, Fumiko Watanabe [Graduate School of Science, Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8578 (Japan); Zhu Liping; Wang Junbo [Institute of Tibetan Plateau Research, Chinese Academy of Science, No. 18 Shuangqing Road, Haidian District, Beijing 100085 (China); Kakegawa, Takeshi [Graduate School of Science, Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8578 (Japan); Nishimura, Mitsugu [School of Marine Science and Technology, Tokai University, 3-20-1 Orido, Shimizu, Shizuoka 424-0902 (Japan)

    2013-01-15

    Paleoclimatic records from the Tibetan Plateau provide important clues for understanding the Asian monsoon and Asian climate systems. To reconstruct climatic and environmental changes in the southern Tibetan Plateau, a 3.77-m-long sediment core (PY608E-PC) was taken from the southeastern part of Lake Pumoyum Co in August 2006. Because terrestrial plant residues are extremely rare in this core, we performed radiocarbon dating on the total organic carbon fraction. We also estimated the old carbon effect and radiocarbon reservoir age of the total organic carbon fraction. Using these estimates, we propose a new radiocarbon chronology for past climatic changes from ca. 12,500 to 700 cal BP. The linear sedimentation rate of the core was founded to be constant at 32.0 cm/kyr, indicating stable sedimentation conditions in Lake Pumoyum Co from the period of the Younger Dryas to the Holocene.

  3. Comment on "Proposal of a critical test of the Navier-Stokes-Fourier paradigm for compressible fluid continua".

    Science.gov (United States)

    Felderhof, B U

    2013-08-01

    Recently, a critical test of the Navier-Stokes-Fourier equations for compressible fluid continua was proposed [H. Brenner, Phys. Rev. E 87, 013014 (2013)]. It was shown that the equations of bivelocity hydrodynamics imply that a compressible fluid in an isolated rotating circular cylinder attains a nonequilibrium steady state with a nonuniform temperature increasing radially with distance from the axis. We demonstrate that statistical mechanical arguments, involving Hamiltonian dynamics and ergodicity due to irregularity of the wall, lead instead to a thermal equilibrium state with uniform temperature. This is the situation to be expected in experiment.

  4. Peritonitis fúngica en diálisis peritoneal continua ambulatoria: descripción de 10 casos

    OpenAIRE

    García Martos, P.; Gil de Sola, F.; Marín, P.; García-Agudo, L.; García-Agudo, R.; Tejuca, F.; Calle, L.

    2009-01-01

    Antecedentes: La peritonitis fúngica es una complicación infrecuente pero grave en pacientes en diálisis peritoneal continua ambulatoria (DPCA). Métodos: Durante un período de 10 años (1999-2008), de un total de 175 pacientes con insuficiencia renal crónica en tratamiento con DPCA, estudiamos retrospectivamente 10 casos de peritonitis fúngica, analizando los factores predisponentes, aspectos clínicos, agentes etiológicos y tratamiento. El diagnóstico se estableció por la presencia de efluente...

  5. Uso de ecuaciones estructurales en áreas de manufactura y mejora continua. El caso de plantas de manufactura

    Directory of Open Access Journals (Sweden)

    Carlos Monge

    2016-03-01

    Full Text Available El uso de la modelación mediante ecuaciones estructurales ha sido empleado de manera amplia en las áreas de las ciencias del comportamiento, mercadotecnia, preferencias del consumidor y servicio al cliente. Sin embargo, existe poca bibliografía que muestre su uso en áreas de manufactura, calidad o mejora continua. El presente artículo presenta la aplicación exitosa, estadísticamente significativa y relevante de ecuaciones estructurales en una investigación realizada en plantas de manufactura de Apodaca, México. En ese estudio se analizan aspectos de manufactura y mejora continua y su impacto en la eficiencia operacional de las plantas, y se presentan los resultados de la aplicación en las áreas mencionadas, sugiriendo que las ecuaciones estructurales pueden ser utilizadas  en distintas áreas con la misma eficacia y confiabilidad que otras técnicas estadísticas de análisis multivariado.

  6. More Than a Feeling? An Empirical Analysis of the Dual-Continua Model on a National Sample of Lesbian, Gay, and Bisexual Identified Canadians.

    Science.gov (United States)

    Peter, Tracey

    2017-08-11

    The goal of the study is to investigate whether positive mental health complements mental illness within a theoretically informed (the dual-continua model) and psychometrically tested (the Mental Health Continuum-Short Form) framework. National-level, population-based data from the 2012 Canadian Community Health Survey on Mental Health (CCHS-MH) was used, with comparisons between sexual minority and heterosexual adults. Results show that gay, lesbian, and bisexual Canadians have substantially lower rates of positive mental health and are more likely to have been diagnosed with a mental illness, with the disparities between health and illness being the most pronounced among lesbians and bisexual females. Results show considerable support for the dual-continua model, which posits that the absence of health does not automatically translate into the presence of illness, and vice versa. Suggestions are made for practitioners and researchers toward the use of the dual-continua model as a surveillance tool, especially among sexual minority individuals.

  7. Estudio exploratorio de las propiedades psicométricas de la Escala de Personalidad Creadora (EPC en su versión Heteroevaluación

    Directory of Open Access Journals (Sweden)

    Gabriela Krumm

    2011-01-01

    Full Text Available El objetivo de esta investigación fue evaluar de modo exploratorio el funcionamiento en nuestro medio, de la Escala de Personalidad Creadora (EPC de Garaigordobil (2004 en su versión heteroevaluación. La muestra estuvo constituida por 160 padres, con hijos de 9 a 12 años, seleccionados de manera intencional de la provincia de Entre Ríos (Argentina. Se analizó el poder discriminativo de los ítems y la consistencia interna por medio del coeficiente Alpha de Cronbach. Tanto el índice de Kaiser-Meyer y Olkin (KMO y el Test de Esfericidad de Bartlett, indicaron la viabilidad de factorizar la escala por lo que la estructura del instrumento fue estudiada a través de un Análisis Factorial de componentes principales con rotación oblicua. El instrumento presentó una adecuada consistencia interna y todos sus ítems resultaron discriminativos. Por otra parte, al comparar la estructura factorial de la versión autoevaluación presentada por la autora, con la versión heteroevaluación, obtenida en este estudio, se observó que si bien se mantuvo el número de factores en cinco, tal como propone la autora, los ítems se redistribuyeron, generando una nueva clasificación de los mismos.

  8. Special topic interoperability and EHR: Combining openEHR, SNOMED, IHE, and continua as approaches to interoperability on national ehealth

    DEFF Research Database (Denmark)

    Bestek, M.; Stanimirovi, D.

    2017-01-01

    into the eHealth environment, and identification of the main success factors in the field, which are necessary for achieving required interoperability, and consequently, for the successful implementation of eHealth projects in general. Methods: The paper represents an in-depth analysis regarding...... the potential application of openEHR, SNOMED, IHE and Continua approaches in the development and implementation process of eHealth in Slovenia. The research method used is both exploratory and deductive in nature. The methodological framework is grounded on information retrieval with a special focus on research...... could alleviate the pertinent interoperability issues in the Slovenian eHealth context. 2. Analyzing the possibilities (requirements) for their inclusion in the construction process for individual eHealth solutions. 3. Identification and charting the main success factors in the interoperability field...

  9. Inventarios probabilísticos con demanda independiente de revisión continua, modelos con nuevos pedidos

    Directory of Open Access Journals (Sweden)

    Francy Ríos

    2008-01-01

    Full Text Available El propósito de este trabajo es explicar el sistema de inventario probabilístico con demanda independiente y revisión continua, con nuevos pedidos. Este análisis se realiza considerando la importancia que este tipo de modelos tiene para la adecuada toma de decisiones sobre la adquisición y manejo óptimo de recursos en las empresas. Estos modelos se caracterizan por poseer una demanda y/o tiempo de suministro variables en el tiempo y la necesidad o demanda del artículo es generada como consecuencia de las decisiones de muchos actores ajenos a la cadena logística (clientes o consumidores, por lo que la empresa no tiene control de la misma.

  10. Categories and continua of destructive and constructive marital conflict tactics from the perspective of U.S. and Welsh children.

    Science.gov (United States)

    Goeke-Morey, Marcie C; Cummings, E Mark; Harold, Gordon T; Shelton, Katherine H

    2003-09-01

    Categories and continua of parents' marital conflict tactics based on multiple, conceptually grounded criteria were tested. Participants were 175 U.S. children, ages 8-16 years (88 boys, 87 girls) and 327 Welsh children, ages 11-12 years (159 boys, 168 girls). Children's responses (affective, cognitive, behavioral) to analog presentations of 10 everyday marital conflict tactics enacted by fathers or mothers showed substantial variation as a function of tactic used. Orderings of conflict tactics on the various response criteria varied as a function of moderators, particularly the gender of the parent expressing the conflict tactic. Conflict tactics were classified as either constructive or destructive according to criteria derived from the emotional security hypothesis. Except for calm discussion, classifications did not change regardless of cultural group, parent gender, or child age or gender. Recommendations for negotiating everyday marital conflict for the children's sake are discussed.

  11. Evolución de la participación del personal en la mejora continua en España.

    OpenAIRE

    García Lorenzo, Anotnio; Prado Prado, José Carlos

    2001-01-01

    La mejora continua constituye una vía fundamental para mantener e incrementar la competitividad de las compañías. Debido a que se sustenta en la contribución de todos los miembros de una organización, es necesario habilitar mecanismo

  12. German Adjuvant Intergroup Node-positive Study (GAIN): a phase III trial comparing two dose-dense regimens (iddEPC versus ddEC-PwX) in high-risk early breast cancer patients.

    Science.gov (United States)

    Möbus, V; von Minckwitz, G; Jackisch, C; Lück, H-J; Schneeweiss, A; Tesch, H; Elling, D; Harbeck, N; Conrad, B; Fehm, T; Huober, J; Müller, V; Bauerfeind, I; du Bois, A; Loibl, S; Nekljudova, V; Untch, M; Thomssen, C

    2017-08-01

    Dose-dense (dd) regimens are one of the preferred options for the adjuvant treatment of breast cancer patients with intermediate to high risk. The German Adjuvant Intergroup Node-positive trial aimed at optimizing intense dd (idd) strategies by evaluating drug combinations and the addition of capecitabine. Women (aged 18 years and biologically <65 years) with histologically involved axillary lymph nodes were randomly assigned to receive three courses each of epirubicin (E) 150 mg/m2, paclitaxel (P) 225 mg/m2 and cyclophosphamide (C) 2500 mg/m2 (reduced to 2000 mg/m2 after recruitment of 1200 patients) q2w intravenously (i.v.) (iddEPC-regimen) or ddEC (E 112.5 mg/m2 + C 600 mg/m2, i.v. q2w for 4 cycles) followed by paclitaxel weekly (Pw 67.5 mg/m2 i.v. q8d for 10 weeks) plus capecitabine (X 2000 mg/m2 p.o. days 1-14, q22 for 4 cycles) (ddEC-PwX-regimen). Further randomization assigned patients to ibandronate for 2 years versus observation and to pegfilgrastim day 2 versus 4. From June 2004 to August 2008, 2994 patients were randomized to either iddEPC (N = 1498), or ddEC-PwX (N = 1496) and started treatment. Median age was 50 years; pN1 (37.8%), pN2 (35.3%); pN3 (26.9%); 46.4% were G3 tumors; 76.9% hormone receptor-positive and 22% HER2-positive. After a median follow-up of 74 months, 645 events and 383 deaths were recorded. Hematological adverse events grades 3-4 were more common with iddEPC (P < 0.001), nonhematological with ddEC-PwX (P = 0.04), even if the toxicity profile of the two regimens was different. At 5 years, estimated disease-free survival rates for ddEC-PwX and iddEPC were 81.7% [95% confidence interval (CI) 79.5-83.6] versus 80.2% (95% CI 78.0-82.2). Hazard ratio (HR)=0.95 (95% CI 0.81-1.11, log-rank P = 0.49). Five-year overall survival rates were 89.4% for ddEC-PwX (95% CI 87.7-91.0) and 89.0% for iddEPC (95% CI 87.2-90.6), HR = 0.85 (95% CI 0.69-1.04, log-rank P = 0.10). Adding

  13. Estrategia integral de formación para la mejora continua de la calidad de los servicios de salud

    Directory of Open Access Journals (Sweden)

    Laura Magaña Valladares

    2015-05-01

    Full Text Available El sistema de salud mexicano ha tenido logros importantes que se reflejan en la mejora creciente del nivel de salud. Empero, la heterogeneidad en la calidad de los servicios y su repercusión en la salud de diferentes grupos poblacionales continúan siendo un reto. Los costos de fallos en la calidad representan de 20 a 40% del gasto de los sistemas de salud. Es necesario desarrollar la capacidad organizacional para implementar sistemas de gestión de calidad que permitan identificar, evaluar, superar y prevenir los retos del sistema de salud. Para ello, se propone una estrategia integral de formación de recursos humanos basada en competencias y responsabilidades, que incluye programas de pregrado, posgrado y educación continua para favorecer el ejercicio efectivo de la función de calidad en los diversos niveles de responsabilidad del sistema de salud. La estrategia responde a las necesidades del sistema mexicano, pero puede ser adaptada a diferentes sistemas y contextos.

  14. Energy-momentum conserving higher-order time integration of nonlinear dynamics of finite elastic fiber-reinforced continua

    Science.gov (United States)

    Erler, Norbert; Groß, Michael

    2015-05-01

    Since many years the relevance of fibre-reinforced polymers is steadily increasing in fields of engineering, especially in aircraft and automotive industry. Due to the high strength in fibre direction, but the possibility of lightweight construction, these composites replace more and more traditional materials as metals. Fibre-reinforced polymers are often manufactured from glass or carbon fibres as attachment parts or from steel or nylon cord as force transmission parts. Attachment parts are mostly subjected to small strains, but force transmission parts usually suffer large deformations in at least one direction. Here, a geometrically nonlinear formulation is necessary. Typical examples are helicopter rotor blades, where the fibres have the function to stabilize the structure in order to counteract large centrifugal forces. For long-run analyses of rotor blade deformations, we have to apply numerically stable time integrators for anisotropic materials. This paper presents higher-order accurate and numerically stable time stepping schemes for nonlinear elastic fibre-reinforced continua with anisotropic stress behaviour.

  15. Interpretación y medición comparada de líneas granulométricas continuas

    Directory of Open Access Journals (Sweden)

    Grinszpan, Pedro Enrique

    1979-12-01

    Full Text Available Not avaible

    Se propone en este trabajo una expresión analítica que vincula al módulo de finura de Abrams con el tamaño límite superior de la serie granulométrica y con el grado de una función parabólica identificable con la analizada a efectos de poder localizar la composición con relación a los dominios de conveniencia establecidos por las normas y de este modo realizar una medición comparada de su aptitud. Se introduce el concepto de coeficiente de aptitud a efectos de medir en términos relativos la bondad de una composición granulométrica continua y se propone una escala de clasificación y calificación, cuya inclusión en los pliegos de especificaciones se recomienda para la recepción de los agregados. Por último, la función adoptada, que se considera una generalización de la distribución dé Gessner, es comparada con las de Bolomey y Ross, estableciéndose la diferencia con éstas.

  16. APLICACIÓN DEL PROCESO DE INTEGRACIÓN CONTINUA EN EL CENTRO DE TELEMÁTICA DE LA UNIVERSIDAD DE LAS CIENCIAS INFORMÁTICAS

    Directory of Open Access Journals (Sweden)

    Hernández A

    2014-06-01

    Full Text Available La Integración Continua es una práctica de software expuesta por Martin Fowler, que permite entre otras bondades la reducción de riesgos y la realización de tareas repetitivas, automatizando al máximo los procesos involucrados en el desarrollo de software y permitiendo la generación de software listo para desplegar e incremento de su calidad. Cuando se cumplen los principios que rigen la Integración Continua se obtiene una herramienta eficaz y útil que ayuda a la sinergia del desarrollo de los proyectos de software. En este trabajo se pretenden mostrar las experiencias en la utilización del proceso de Integración Continua en el centro de Telemática de la Universidad de las Ciencias Informáticas. Se presentan las etapas, herramientas utilizadas y resultados obtenidos con la aplicación de esta técnica, resaltando las ventajas que se obtienen para todas las personas involucradas, principalmente los desarrolladores, los cuales son los mayores implicados en este proceso. Se utilizan los lenguajes de programación PHP y Python por ser éstos los utilizados en el centro y como servidor de Integración Continua Jenkins, uno de los más populares, robusto y fácil de usar. Las etapas y herramientas que fueron establecidas son libres de ser modificadas de acuerdo a las necesidades que se requieran.

  17. Análisis de la producción científica hispana en mejora continua: 1990-2011

    Directory of Open Access Journals (Sweden)

    Sánchez, Lidia

    2016-03-01

    Full Text Available The aim of this paper is to present the results of a review of Hispanic literature about continuous improvement. A rigorous review of papers included in the Dialnet data base was conducted, combining both qualitative and quantitative methods. The main results show that continuous improvement is an important field in Hispanic output although certain topics should be delved into more deeply. General knowledge journals aimed at practitioners are those that tend to publish papers related to continuous improvement, thus highlighting the relevance of the topic for practitioners. The paper offers two main contributions. First, it is novel research not been previously done in the Hispanic context. Secondly, it clarifies and complements the conclusions drawn by international reviews according to which continuous improvement seemed to be scarcely addressed in Hispanic output.El objetivo de este trabajo es realizar una revisión del campo de la Mejora Continua en la literatura. Para ello se realiza una revisión rigurosa tanto con métodos cualitativos como cuantitativos a partir de los trabajos recogidos en la base de datos Dialnet. Los principales resultados muestran que la mejora continua es un campo importante en la literatura hispana, aunque debe potenciarse en ciertas temáticas. También se detectó una clara orientación divulgativa del tema resaltando así la importancia de la mejora continua para los profesionales del sector. El trabajo tiene dos aportaciones principales. En primer lugar, es un estudio novedoso que no se había realizado previamente en la literatura hispana. Y, en segundo lugar, matiza y complementa las conclusiones obtenidas por revisiones internacionales según las cuales la mejora continua parecía no estar desarrollada en la literatura hispana.

  18. Jornada escolar partida y continua. ¿Existen evidencias que motiven el cambio en la gestión del tiempo escolar en España?

    Directory of Open Access Journals (Sweden)

    Francisco José Morales Yago

    2017-07-01

    Full Text Available El efecto del tipo de jornada escolar (partida frente a continua sobre los resultados de los estudiantes ha sido un tema poco estudiado, aunque conflictivo en el ámbito nacional por sus implicaciones sociales y laborales. Los objetivos generales del trabajo son dos: primero constatar si existe asociación entre resultados académicos y tipo de jornada escolar y, segundo, analizar las preferencias del profesorado por un tipo u otro de jornada y las razones que las motivan. Trascurridas tres décadas desde que comenzó a implantarse la jornada continua en algunas comunidades autónomas, se puede concluir que los progresos académicos esperados han sido reducidos y equiparables a los experimentados por comunidades que han permanecido en jornada escolar partida. Para realizar un estudio de la cuestión desde la percepción del profesorado, se ha utilizado metodología de encuesta (N=400, combinada con entrevistas semiestructuradas (N=30. Los resultados evidencian que los profesores prefieren la jornada escolar continua, aduciendo motivos como la posibilidad de incrementar su formación o menos desplazamientos al centro.

  19. Eficacia y seguridad de la terbinafina oral en pauta intermitente o pulsátil versus pauta continua para el tratamiento de la onicomicosis en mayores de 18 años

    Directory of Open Access Journals (Sweden)

    Ernesto Andrade Cerquera

    2016-01-01

    Conclusiones. La terbinafina intermitente tiene menor éxito de cura clínica y micológica que la continua; su RR corregido demuestra que la pauta intermitente es 13% menos eficiente que la continua. Clínicamente los hallazgos son significativos pero estadísticamente falta poder en los estudios y un mayor tamaño de muestra agrupado para mejorar la evidencia.

  20. Rasmussen's encephalitis presenting as focal cortical dysplasia

    Directory of Open Access Journals (Sweden)

    D.J. O'Rourke

    2014-01-01

    Full Text Available Rasmussen's encephalitis is a rare syndrome characterized by intractable seizures, often associated with epilepsia partialis continua and symptoms of progressive hemispheric dysfunction. Seizures are usually the hallmark of presentation, but antiepileptic drug treatment fails in most patients and is ineffective against epilepsia partialis continua, which often requires surgical intervention. Co-occurrence of focal cortical dysplasia has only rarely been described and may have implications regarding pathophysiology and management. We describe a rare case of dual pathology of Rasmussen's encephalitis presenting as a focal cortical dysplasia (FCD and discuss the literature on this topic.

  1. Rasmussen's encephalitis presenting as focal cortical dysplasia

    Science.gov (United States)

    O'Rourke, D.J.; Bergin, A.; Rotenberg, A.; Peters, J.; Gorman, M.; Poduri, A.; Cryan, J.; Lidov, H.; Madsen, J.; Harini, C.

    2014-01-01

    Rasmussen's encephalitis is a rare syndrome characterized by intractable seizures, often associated with epilepsia partialis continua and symptoms of progressive hemispheric dysfunction. Seizures are usually the hallmark of presentation, but antiepileptic drug treatment fails in most patients and is ineffective against epilepsia partialis continua, which often requires surgical intervention. Co-occurrence of focal cortical dysplasia has only rarely been described and may have implications regarding pathophysiology and management. We describe a rare case of dual pathology of Rasmussen's encephalitis presenting as a focal cortical dysplasia (FCD) and discuss the literature on this topic. PMID:25667877

  2. Nuevo método de sutura subcutánea percutánea continua New method of continuous percutaneous subcutaneous suture

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    Germán Brito Sosa

    2012-06-01

    Full Text Available Objetivos: realizar un método de sutura continua, en las personas operadas en el Hospital "Julio Trigo López", que disminuya los granulomas a nivel de la herida quirúrgica, y compararlas con el método tradicional. Métodos: se realizó un estudio experimental sobre la aplicación de un método de sutura subcutánea percutánea continua, en un grupo de pacientes operados de diversas enfermedades, ya sea de urgencia, electivo o ambulatorio, en el Hospital "Julio Trigo López", en los años 2008 y 2009. Resultados: con el método de sutura subcutánea percutánea continua con nylon no se forman granulomas, mientras que con el método tradicional, sí ocurre en un porcentaje no despreciable. Las ventajas del método de sutura subcutánea percutánea continua con nylon son: en el plano celular subcutáneo de la pared abdominal no queda sutura, no se producen granulomas y es más económica. Conclusiones: la sutura de nylon es menos rechazada que la del cromado, ya que no se producen granulomas. El método de sutura subcutánea percutánea continua es una sutura más hemostática que el método tradicional, ya que el por ciento de hematomas es menor. El gasto económico es menor con el método de sutura subcutánea percutánea continua. Con el método de sutura subcutánea percutánea continua la sutura es extraída al 10mo. día de haberla aplicado.Objectives: to apply a continuous suture method to reduce granulomas in surgical wounds in patients operated on at "Julio Trigo Lopez" hospital, and to compare the results with those of the traditional method. Methods: an experimental study was conducted on the application of a continuous percutaneous subcutaneous suture in a group of patients operated on from several diseases, either under emergency, elective or outpatient conditions at "Julio Trigo Lopez" hospital during 2008 and 2009. Results: the continuous percutaneous subcutaneous suture method with nylon prevents formation of granulomas, whereas

  3. Modeling plant composition as community continua in a forest landscape with LiDAR and hyperspectral remote sensing.

    Science.gov (United States)

    Hakkenberg, C R; Peet, R K; Urban, D L; Song, C

    2018-01-01

    In light of the need to operationalize the mapping of forest composition at landscape scales, this study uses multi-scale nested vegetation sampling in conjunction with LiDAR-hyperspectral remotely sensed data from the G-LiHT airborne sensor to map vascular plant compositional turnover in a compositionally and structurally complex North Carolina Piedmont forest. Reflecting a shift in emphasis from remotely sensing individual crowns to detecting aggregate optical-structural properties of forest stands, predictive maps reflect the composition of entire vascular plant communities, inclusive of those species smaller than the resolution of the remotely sensed imagery, intertwined with proximate taxa, or otherwise obscured from optical sensors by dense upper canopies. Stand-scale vascular plant composition is modeled as community continua: where discrete community-unit classes at different compositional resolutions provide interpretable context for continuous gradient maps that depict n-dimensional compositional complexity as a single, consistent RGB color combination. In total, derived remotely sensed predictors explain 71%, 54%, and 48% of the variation in the first three components of vascular plant composition, respectively. Among all remotely sensed environmental gradients, topography derived from LiDAR ground returns, forest structure estimated from LiDAR all returns, and morphological-biochemical traits determined from hyperspectral imagery each significantly correspond to the three primary axes of floristic composition in the study site. Results confirm the complementarity of LiDAR and hyperspectral sensors for modeling the environmental gradients constraining landscape turnover in vascular plant composition and hold promise for predictive mapping applications spanning local land management to global ecosystem modeling. © 2017 by the Ecological Society of America.

  4. Mejora continua de la calidad en una unidad médica de valoración de incapacidad temporal

    Directory of Open Access Journals (Sweden)

    Esther Álvarez Theurer

    2007-06-01

    Full Text Available Objetivo: Nuestro objetivo es el diseño de un plan de mejora continua de la calidad en una Unidad Medica de Valoración de Incapacidades (UMVI. Métodos: La metodología utilizada sigue las directrices marcadas por la Consejería de Salud, en cuanto a procesos e indicadores, que se recogen en el Plan Anual de Inspección. En nuestra Unidad estamos implantando el modelo EFQM de Excelencia. Resultados: Se expone nuestra propuesta de Plan de Calidad para la UMVI. Conclusiones: Destacamos la falta de formación de los profesionales sanitarios responsables de la prescripción de la prestación de IT. Existe unanimidad respecto a la necesidad de unificar criterios de gestión de la Incapacidad Temporal, por lo que seria interesante consensuar este documento con el resto de Unidades Medicas de Valoración de Incapacidades que realizan su trabajo en la Comunidad Autónoma Andaluza, pudiéndose extender a otras Autonomías.Objective: Our objective is design a continuous improvement quality plan in the Medical Unit for Disabilities Valuation (MUDV. Methods: The used methodology follows the guidelines marked by the Health Council, as for processes and indicators that are picked up in the Annual Plan of Inspection. In our Unit we are implanting the EFQM pattern of Excellency. Results: Our proposal of Quality Plan is exposed for the MUDV. Conclusions: We highlight the lack of the sanitary professionals' responsible for the benefit prescription of the of Temporary Disability (DT formation. Unanimity exists regarding the necessity of unifying approaches to administrate the DT. It would be interesting staying according to this document with other Medical Units for Disabilities Valuation that carries out its work in the Andalusia Autonomous Community, being able to extend to other Autonomies.

  5. Power1D: a Python toolbox for numerical power estimates in experiments involving one-dimensional continua

    Directory of Open Access Journals (Sweden)

    Todd C. Pataky

    2017-07-01

    Full Text Available The unit of experimental measurement in a variety of scientific applications is the one-dimensional (1D continuum: a dependent variable whose value is measured repeatedly, often at regular intervals, in time or space. A variety of software packages exist for computing continuum-level descriptive statistics and also for conducting continuum-level hypothesis testing, but very few offer power computing capabilities, where ‘power’ is the probability that an experiment will detect a true continuum signal given experimental noise. Moreover, no software package yet exists for arbitrary continuum-level signal/noise modeling. This paper describes a package called power1d which implements (a two analytical 1D power solutions based on random field theory (RFT and (b a high-level framework for computational power analysis using arbitrary continuum-level signal/noise modeling. First power1d’s two RFT-based analytical solutions are numerically validated using its random continuum generators. Second arbitrary signal/noise modeling is demonstrated to show how power1d can be used for flexible modeling well beyond the assumptions of RFT-based analytical solutions. Its computational demands are non-excessive, requiring on the order of only 30 s to execute on standard desktop computers, but with approximate solutions available much more rapidly. Its broad signal/noise modeling capabilities along with relatively rapid computations imply that power1d may be a useful tool for guiding experimentation involving multiple measurements of similar 1D continua, and in particular to ensure that an adequate number of measurements is made to detect assumed continuum signals.

  6. El numeral 8 de la norma y la mejora continua en las empresas de Ibagué

    Directory of Open Access Journals (Sweden)

    Mario Enrique Uribe Macías

    2015-03-01

    Full Text Available El proyecto de investigación se realizó a partir de la aplicación de un cuestionario estructurado, diseñado con base en la Norma ISO 9004, a siete empresas que habían sido certificadas, siendo una muestra definida por conveniencia. El artículo presenta los resultados del análisis de la aplicación del numeral 8 de la norma “Medición, análisis y mejora”, resaltándose dos grandes conclusiones: el alto grado de autoapreciación que las empresas tienen de su gestión del Sistema de calidad y la aplicación, desarrollo y demostración de las acciones que ellas adelantan se enfocan a mejorar la eficacia de sus sistemas de calidad y a fortalecer su cultura de calidad.Palabras clave: Calidad; Mejora continua; Numeral 8 Norma ISO. Standard ítem 8 and continue improvement in enterprises from IbagueAbstractThe research project was developed by a structured questionnaire application, designed ISO 9004 based-on, to seven certified enterprises that formed a sample chosen by convenience method. This paper presents the results of application of Standard numeral 8. Measuring, analysis and improve behavior analysis, emphasizing two great conclusions: the self-appreciation high level enterprises have about theirs Quality system management, and the application, development and demonstration about the actions they do are focused to improve their  quality systems efficacy and to strengthen their quality culture.Keywords: Quality; Continue improving; Standard ISO numeral 8.

  7. Significance of Gram's stain smear, potassium hydroxide mount, culture, and microscopic pathology in the diagnosis of acrodermatitis continua of Hallopeau.

    Science.gov (United States)

    Sehgal, Virendra N; Sharma, Sonal

    2011-01-01

    A 21-year-old housewife presented to the authors' clinic in 2009 with recurrent papulovesicular and pustular eruptions on the index an ring fingers of the left hand accompanied by throbbing pain that had been active for the past 10 years. The condition did not respond to topical and/or systemic treatment. There was neither a personal/family history of psoriasis nor any other systemic disease. The sk surface of the patient's left hand was marked by the presence of multiple pustules located over an erythematous background, affecting th ring and adjoining middle fingers, with crusting prominent in places along the tips (Figure 1). Gram-stained smears prepared from th purulent specimen revealed Gram-positive cocci in clusters. Potassium hydroxide (KOH) examination of the pustules did not show a fungal elements. In vitro culture of the same specimen yielded growth of Staphylococcus aureus, which was found to be sensitive to almo all conventional antibiotics on aerobic culture. Sections prepared from the skin of the tip of the patient's finger showed marked epithelial hyperplasia with uniform elongation of rete ridges and supra-papillary thinning of the epidermis. There was hyperkeratosis with foci of mounds of parakeratosis. Spongiosis with neutrophilic infiltration and microabscess formation were prominent. The dermis showed perivascular lymphohistiocytic infiltrate (Figure 2A and 2B). No organism was identified on special stains. Results from hemography and liver and renal function tests were within normal limits. The diagnosis of acrodermatitis continua of Hallopeau (ACH) was made, in keeping with the findings. The patient received ceftriaxone 1.0 g and tazobactam 125 mg by slow intravenous infusion for 3 consecutive days, following which there was complete regression of the lesions. After cessation of therapy, there was complete recurrence.

  8. Advanced mechanics of continua

    CERN Document Server

    Surana, Karan S

    2014-01-01

    IntroductionConcepts and Mathematical PreliminariesIntroductionSummation ConventionDummy Index and Dummy VariablesFree IndicesVector and Matrix NotationIndex Notation and Kronecker DeltaPermutation TensorOperations Using Vector, Matrix, and Einstein's NotationChange of Reference Frame, Transformations, TensorsSome Useful RelationsSummary Kinematics of Motion, Deformation and Their MeasuresDescription of MotionLagrangian and Eulerian DescriptionsMaterial Particle Displacements Continuous Deformation and Restrictions on the MotionMaterial Derivative Acceleration of a Material ParticlesCoordinate

  9. La formación continua en España: balance y retos de futuro. [Continous training in spain: situation and challenges

    Directory of Open Access Journals (Sweden)

    Pilar Pineda Herrero

    2007-04-01

    Full Text Available The article presents the results of a research on the situation of continuous training in Spain. The study focus on analysing the situation of this area of training, identifying the opinions of the agents involved, and see the challenges that training has to face in the near future. The method used are the interviews to key agents of continuous training. The results show that, although during the last decade training has improved notoriously –both from a quantity and from a quality point of view- there is still a lot to do, specially in the case of small companies and of workers with a low training level. El artículo presenta los resultados de un estudio que pretende analizar la formación continua en España. El estudio describe la situación en que se halla este subsistema de formación, analiza como lo valoran los agentes implicados y apunta los retos de futuro que debe afrontar para ser una estrategia efectiva en el mantenimiento del empleo y la mejora de su calidad. La metodología utilizada es eminentemente cualitativa, centrada en la realización de entrevistas a los agentes clave de la formación continua. Los resultados muestran que, a pesar de que en la última década la formación continua ha mejorado notablemente tanto a nivel de cantidad como de calidad, aun queda mucho camino por recorrer, sobre todo en el caso de las empresas pequeñas y de los colectivos laborales con menos formación.

  10. Identificando los limitantes de generación de efectivo: bases para una metodología de mejora continua

    Directory of Open Access Journals (Sweden)

    Rivera, Igor

    2013-04-01

    Full Text Available Inside organisations we always find constraints which the cash generation process a long and tortuous path. Our aim in this article is to offer a theoretical review of these constraints, from the process of transformation through to value added. This review takes a different point of view from classical management, focusing on small and medium-sized already established manufacturing organisations. Finally, the article mentions guidelines, with regards to cash generation, which propose continuous improvement: retrospective analysis and identifying the critical process; Defining key parameters and strategic piloting; Identifying the main element which limits cash generation within the critical process; Defining an action plan to reduce, control or eliminate the constraints on generation. Establishing the previous steps as a continuous cycle.Dentro de las organizaciones encontramos limitantes que hacen del proceso de generación de efectivo un largo y penoso camino. Nuestro objetivo en este artículo es hacer una revisión teórica sobre los limitantes de generación de efectivo (LGE, desde el proceso de transformación hasta el valor añadido. Esta revisión establece un punto de vista diferente a aquella establecida por la teoría clásica del management y está enfocada a las pequeñas y medianas empresas (Pymes de manufactura que no sean de reciente creación. Finalmente, el escrito menciona pautas para proponer una mejora continua, con respecto a la generación de efectivo: El análisis retrospectivo y la identificación del proceso crítico; La definición de parámetros clave y el pilotaje estratégico; La identificación dentro del proceso crítico del principal elemento que limita la generación de efectivo; La definición de un plan de acción para poder reducir, controlar o eliminar el limitante de generación. El establecer los pasos anteriores como un ciclo continuo.

  11. Formación profesional y continua de los técnicos de nivel medio. Experiencia cubana

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    Luis Téllez Lazo

    2015-05-01

    Full Text Available El resultado que se presenta tuvo como finalidad perfeccionar el proceso de formación profesional y continua de los técnicos medios, enmarcado en los estudios de profundización del proyecto de investigación: la formación técnico-profesional en las empresas de la provincia Las Tunas. Se partió de un diagnóstico del contexto donde se forman los estudiantes y graduados de nivel medio en varias especialidades técnicas, el cual incluyó, profesores, tutores, trabajadores y adiestrados. El objetivo de este estudio fue ofrecer una concepción pedagógica para el perfeccionamiento de la Educación Técnica y Profesional, en las condiciones de integración escuela-empresa, sobre la base de criterios científicos, que le permitan a las autoridades locales y directivos de los Institutos Politécnicos de la provincia, tomar decisiones en beneficio de la calidad de la formación en este tipo de instituciones educativas. La investigación se sustentó en la teoría de la educación avanzada (Añorga, 1999 y la teoría de la Pedagogía Profesional (Abreu, 2004 y enriquecidas por sus seguidores hasta la actualidad. Se utilizó la metodología de la investigación acción participativa, mediante el desarrollo del método talleres de opinión crítica y construcción colectiva, así como se determinaron los indicadores, instrumentos y técnicas que permitieron indagar en los cambios cualitativos que experimentaron los sujetos y procesos objeto de estudio. Los resultados impactan en directivos, estudiantes, profesores y tutores, con la novedad del acompañamiento pedagógico como forma de superación del tutor y la concepción de dirección de las prácticas preprofesionales.

  12. Las dosis recomendadas de β-lactámicos en el paciente séptico con técnicas continuas de reemplazo renal son insuficientes

    OpenAIRE

    Paz Martín, Daniel

    2012-01-01

    La sepsis es una causa importante de morbi-mortalidad entre los pacientes ingresados en Unidades de Cuidados Intensivos (UCI). En estos pacientes es prioritario tanto el control de la causa como el inicio temprano de la antibioterapia. De hecho, el retraso en el adecuado tratamiento antibiótico empeora el pronóstico de los pacientes sépticos. El fracaso renal agudo es una complicación frecuente de la sepsis que a menudo  precisa de técnicas continuas de reemplazo renal (TCRR). A pe...

  13. Actividades de evaluación continua y valoración del estudiante: Estudio sobre su correlación

    OpenAIRE

    Pastor, Isidro M.; Trillo Alarcón, María Paz; Alonso, Diego A.; Albert-Soriano, María; Gómez-Martínez, Melania; Baeza, Alejandro; Ramón, Diego J.; Guillena, Gabriela; Chinchilla, Rafael; Gómez Lucas, Cecilia

    2016-01-01

    Nuestro grupo de investigación en docencia del Departamento de Química Orgánica viene desarrollando, en los últimos cursos, estudios sobre la influencia de la evaluación continua (EC) en la calificación final. En general, las calificaciones obtenidas durante el semestre en las diferentes acciones de la EC mejoran las notas finales de los estudiantes. De especial importancia son los créditos asociados a prácticas de laboratorio y la resolución de problemas. En el estudio se ha considerado la v...

  14. Diagnóstico de necesidades de educación continua mediante un método grupal y un método individual

    OpenAIRE

    Maya-Ampudia, Claudia Catalina; Ángeles-Zavala, Oswaldo; Camarena-Olmedo, Javier Alejandro

    2014-01-01

    Introducción: La educación continua debe responder a las necesidades sociales de salud dentro del contexto histórico y social de los profesionistas, para lo cual es necesario contar con información precisa sobre las necesidades de actualización del personal en salud. El método tradicional comúnmente utiliza una encuesta individual, e identifica las necesidades individuales o sentidas del personal, sin referencia a las necesidades reales de la institución, ni del equipo de salud. Un método gru...

  15. Integrating Positive and Clinical Psychology: Viewing Human Functioning as Continua from Positive to Negative Can Benefit Clinical Assessment, Interventions and Understandings of Resilience

    OpenAIRE

    Johnson, J; Wood, AM

    2017-01-01

    In this review we argue in favour of further integration between the disciplines of positive and clinical psychology. We argue that most of the constructs studied by both positive and clinical psychology exist on continua ranging from positive to negative (e.g., gratitude to ingratitude, anxiety to calmness) and so it is meaningless to speak of one or other field studying the “positive” or the “negative”. However, we highlight historical and cultural factors which have led positive and clinic...

  16. Cálculo, mediante la aplicación del algoritmo de ajuste por mínimos cuadrados, de los componentes de velocidad para estaciones GNSS continuas

    Directory of Open Access Journals (Sweden)

    Jorge Moya Zamora

    2014-07-01

    Full Text Available El cálculo de la velocidad de una estación de observación continua GNSS representa un insumo fundamental en la geodesia moderna. El hecho de determinar la posición de las estaciones GNSS de forma diaria implica que se puedan establecer las series temporales de las estaciones, con base en las cuales se puede obtener información de la influencia de fenómenos que afecten el comportamiento de estas. En este artículo se plantea una descripción del algoritmo de ajuste por mínimos cuadrados adaptado y aplicado a la determinación de los componentes de velocidad de estaciones de observación continua. Además, se aplica este algoritmo para la calcular la velocidad de la estación ETCG, perteneciente al Sistema Geocéntrico para las Américas (SIRGAS.

  17. La formación continua en el sector financiero: implicaciones para las mujeres de más de 45 años

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    ESTHER FERNÁNDEZ MOSTAZA

    2003-01-01

    Full Text Available El objeto de estudio es la descripción de las actuaciones en formación continua que actualmente operan en el sector de la intermediación financiera, y más concretamente en el colectivo de mujeres de entre 45 y 55 años, empleadas en el sector bancario durante más de veinte años dentro de categorías poco cualificadas. Con la intención de poner de manifiesto que los determinantes de quién recibe formación en la empresa están muy relacionados con los costes y rendimiento de la inversión en capital humano, dos grandes cuestiones vertebran el núcleo fundamental del artículo: en primer lugar, ¿qué características definen y diferencian la generación de mujeres a la que nos referimos? Una vez trazadas las características, la cuestión es: ¿se benefician estas mujeres de los programas de formación continua de las empresas? Y si no es así, ¿por qué?

  18. Sub-50-as isolated extreme ultraviolet continua generated by 1.6-cycle near-infrared pulse combined with double optical gating scheme

    Science.gov (United States)

    Oguri, Katsuya; Mashiko, Hiroki; Ogawa, Tatsuya; Hanada, Yasutaka; Nakano, Hidetoshi; Gotoh, Hideki

    2018-04-01

    We demonstrate the generation of ultrabroad bandwidth attosecond continua extending to sub-50-as duration in the extreme ultraviolet (EUV) region based on a 1.6-cycle Ti:sapphire laser pulse. The combination of the amplitude gating scheme with a sub-two-cycle driver pulse and the double optical gating scheme achieves the continuum generation with a bandwidth of 70 eV at the full width at half maximum near the peak photon energy of 140 eV, which supports a Fourier-transform-limited pulse duration as short as 32 as. The carrier-envelope-phase (CEP) dependence of the attosecond continua shows a single-peak structure originating from the half-cycle cut-off at appropriate CEP values, which strongly indicates the generation of a single burst of an isolated attosecond pulse. Our approach suggests a possibility for isolated sub-50-as pulse generation in the EUV region by compensating for the intrinsic attosecond chirp with a Zr filter.

  19. ANÁLISIS DE LOS ANGULOS LIMITES DE CONDUCCIÓN CONTINUA-DISCONTINUA EN EL REGULADOR CONMUTADO ELEVADOR COMO CFP

    Directory of Open Access Journals (Sweden)

    Hector S Trujillo Alvarado

    2011-03-01

    Full Text Available En este trabajo se analizan las formas de onda del regulador conmutado elevador como CFP trabajando parte deltiempo en operación continua y parte del tiempo en operación discontinua. Se evidencia el hecho de que los ánguloslímites de conducción no son simétricos respecto al máximo de la onda como sugieren trabajos publicados por otrosautores. La simulación con PSPICE confirma este hecho y a partir de los resultados de la simulación se calculanteóricamente las contribuciones a la corriente de directa en la carga que aportan las zonas discontinuas y la zonacontinua de forma aproximada. Se propone una vía para el cálculo analítico de la zona de operación continua.  The wave forms of a boost switching regulator working as a PFC part time in the continouos mode of operationand part time on the discontinouos mode are analysed. The fact that the limit conduction angles are not symmetricalwith respect to the maximum of the current (on the contrary of what stated in papers published by other authorsare evidenced. PSPICE simulations confirmed this assertion. From these results the contributions to the DC outputcurrent of the different operating zones are theoretically estimated. It is proposed a way to calculate analiticallythe contribution to the DC output current of the continuous zone.

  20. Euromech 579 Arpino 3-8 April 2017: Generalized and microstructured continua: new ideas in modeling and/or applications to structures with (nearly)inextensible fibers—a review of presentations and discussions

    Science.gov (United States)

    Laudato, Marco; Di Cosmo, Fabio

    2018-04-01

    In the present paper, a rational report on Euromech 579, Generalized and Microstructured Continua: New ideas in modeling and/or Applications to Structures with (nearly)inextensible fibers (Arpino 3-8 April 2017), is provided. The main aim of the colloquium was to provide a forum for experts in generalized and microstructured continua with inextensible fibers to exchange ideas and get informed about the latest research trends in the domain. The interested reader will find more details about the colloquium at the dedicated web page http://www.memocsevents.eu/euromech579.

  1. Epileptic palatal myoclonus

    International Nuclear Information System (INIS)

    Tatum, W.O.; Sperling, M.R.; Jacobstein, J.G.

    1991-01-01

    Palatal myoclonus (PM) is usually caused by lesions of the brainstem. The authors report a case of PM of focal cortical origin in a patient with epilepsia partialis continua. The PM sometimes occurred in isolation, and at other times was accompanied by unilateral face, neck, and arm twitching. This was documented by both EEG and SPECT

  2. Epileptic palatal myoclonus

    Energy Technology Data Exchange (ETDEWEB)

    Tatum, W.O.; Sperling, M.R.; Jacobstein, J.G. (Graduate Hospital, Philadelphia, PA (USA))

    1991-08-01

    Palatal myoclonus (PM) is usually caused by lesions of the brainstem. The authors report a case of PM of focal cortical origin in a patient with epilepsia partialis continua. The PM sometimes occurred in isolation, and at other times was accompanied by unilateral face, neck, and arm twitching. This was documented by both EEG and SPECT.

  3. Special Topic Interoperability and EHR: Combining openEHR, SNOMED, IHE, and Continua as approaches to interoperability on national eHealth.

    Science.gov (United States)

    Beštek, Mate; Stanimirović, Dalibor

    2017-08-09

    The main aims of the paper comprise the characterization and examination of the potential approaches regarding interoperability. This includes openEHR, SNOMED, IHE, and Continua as combined interoperability approaches, possibilities for their incorporation into the eHealth environment, and identification of the main success factors in the field, which are necessary for achieving required interoperability, and consequently, for the successful implementation of eHealth projects in general. The paper represents an in-depth analysis regarding the potential application of openEHR, SNOMED, IHE and Continua approaches in the development and implementation process of eHealth in Slovenia. The research method used is both exploratory and deductive in nature. The methodological framework is grounded on information retrieval with a special focus on research and charting of existing experience in the field, and sources, both electronic and written, which include interoperability concepts and related implementation issues. The paper will try to answer the following inquiries that are complementing each other: 1. Scrutiny of the potential approaches, which could alleviate the pertinent interoperability issues in the Slovenian eHealth context. 2. Analyzing the possibilities (requirements) for their inclusion in the construction process for individual eHealth solutions. 3. Identification and charting the main success factors in the interoperability field that critically influence development and implementation of eHealth projects in an efficient manner. Provided insights and identified success factors could serve as a constituent of the strategic starting points for continuous integration of interoperability principles into the healthcare domain. Moreover, the general implementation of the identified success factors could facilitate better penetration of ICT into the healthcare environment and enable the eHealth-based transformation of the health system especially in the countries

  4. Modelos de regresión para variables expresadas como una proporción continua Regression models for variables expressed as a continuous proportion

    Directory of Open Access Journals (Sweden)

    Aarón Salinas-Rodríguez

    2006-10-01

    Full Text Available OBJETIVO: Describir algunas de las alternativas estadísticas disponibles para el estudio de proporciones continuas y comparar los distintos modelos que existen para evidenciar sus ventajas y desventajas, mediante su aplicación a un ejemplo práctico del ámbito de la salud pública. MATERIAL Y MÉTODOS: Con base en la Encuesta Nacional de Salud Reproductiva realizada en el año 2003, se modeló la proporción de cobertura individual en el programa de planificación familiar -propuesta en un estudio previo realizado en el Instituto Nacional de Salud Pública en Cuernavaca, Morelos, México (2005- mediante el uso de los modelos de regresión normal, gama, beta y de quasi-verosimilitud. La variante del criterio de información de Akaike (AIC que propusieron McQuarrie y Tsai se utilizó para definir el mejor modelo. A continuación, y mediante simulación (enfoque Monte Carlo/cadenas de Markov, se generó una variable con distribución beta para evaluar el comportamiento de los cuatro modelos al variar el tamaño de la muestra desde 100 hasta 18 000 observaciones. RESULTADOS: Los resultados muestran que la mejor opción estadística para el análisis de proporciones continuas es el modelo de regresión beta, de acuerdo con sus supuestos y el valor de AIC. La simulación mostró que a medida que aumenta el tamaño de la muestra, el modelo gama y, en especial, el modelo de quasi-verosimilitud se aproximan en grado significativo al modelo beta. CONCLUSIONES: Para la modelación de proporciones continuas se recomienda emplear el enfoque paramétrico de la regresión beta y evitar el uso del modelo normal. Si se tiene un tamaño de muestra grande, el uso del enfoque de quasi-verosimilitud representa una buena alternativa.OBJECTIVE: To describe some of the statistical alternatives available for studying continuous proportions and to compare them in order to show their advantages and disadvantages by means of their application in a practical example of

  5. Un programa de formación continua con profesores de ciencias en el contexto de la relación Museo-Escuela

    Directory of Open Access Journals (Sweden)

    Carlos Soto Lombana

    2012-04-01

    Full Text Available En este artículo se presentan los resultados de un programa de formación continua con ocho profesores de ciencias naturales de educación básica y media, que integró el trabajo de dos museos de ciencia de la ciudad de Medellín, Colombia, como herramienta pedagógica y didáctica. Los resultados del programa de formación permiten apreciar el gran potencial de los museos como recurso educativo y didáctico para la enseñanza de las ciencias naturales. Como principal conclusión se plantea que el diseño de las Unidades Didácticas como parte de un ciclo de aprendizaje, es lo que establece la diferencia entre la acción pedagógica del docente en relación con la visita en el contexto formal del que realiza un colectivo escolar a un museo en el contexto informal.

  6. La utilidad del uso de datos administrativos en la investigación de salud pública: la Muestra continua de vidas laborales

    Directory of Open Access Journals (Sweden)

    María Andrée López

    2014-07-01

    Full Text Available La utilización de datos administrativos es práctica habitual en la investigación en salud pública. El objetivo de este trabajo es describir la Muestra continua de vidas laborales (MCVL y su utilidad en la investigación en salud. La MCVL está construida sobre registros que generan todos los contactos con la Seguridad Social (laborales, incapacidades, etc., más datos fiscales (percepciones dinerarias, ingresos, etc. y del padrón (nivel educativo, país de nacimiento, etc., sin que sea posible la identificación individual. La MCVL se inició en 2004 con el 4% (1,1 millón de personas del total de población cotizante o perceptora de la Seguridad Social. Los datos de las personas que forman parte de la MCVL son actualizados anualmente, y se sustituyen las bajas producidas. Este diseño continuo permite generar una cohorte con información de la vida laboral y económica, y valorar su asociación con la incapacidad laboral. El supuesto de conexión con la historia clínica posibilitaría el análisis de otros resultados de salud.

  7. EL ENFOQUE CLÍNICO EN LA FORMACIÓN CONTINUA DE PROFESORES: LA TEORIZACIÓN DEL «OJO PEDAGÓGICO» COMO DESTREZA COMPLEJA

    Directory of Open Access Journals (Sweden)

    Paola M. Andreucci Annunziata

    2012-01-01

    Full Text Available El presente trabajo se ocupa del enfoque clínico en la formación continua de profesores. Esteenfoque se ha valido de diversos dispositivos para su aplicación. En este caso y, para rescatar la singularidad y agudeza del enfoque, se propone la noción de «ojo pedagógico»conceptualizadacomo destreza compleja y articuladora de aspectos emocionales y racionales de conocimiento pedagógico, que posibilita atender a la dimensión interaccional profesor - alumno y aplicarla a problemáticas de aula. En una primera parte del artículo se establece el estado actual de laformación permanente de profesores y la ineficacia de las propuestas aplicadas a la fecha, luegose presenta y actualiza el enfoque clínico para la investigación y formación docente y, en la últimaparte, se expone y discute la propuesta de teorización sobre el «ojo pedagógico»,diferenciándola de otras propuestas como la de «tacto» o sensibilidad pedagógica (Van Manen, 1998 y, se deslindan algunos desafíos para su implementación práctica.

  8. La modelación matemática en los procesos de formación inicial y continua de docentes

    Directory of Open Access Journals (Sweden)

    José David Zaldívar Rojas

    2017-10-01

    Full Text Available El presente estudio tiene como propósito promover la importancia de los procesos de aprendizaje e implementación del concepto modelación matemática en la formación docente inicial y/o continua. Para ello se describe una propuesta que tiene como fin el que los docentes experimenten y resuelvan una situación basada en modelación matemática tomando estos el rol de alumnos. Se discuten primeramente los aspectos teóricos que sustentan la propuesta y se presentan las dos fases que conforman el estudio. Los resultados muestran un diseño de una situación basada en un contexto biológico cuyas tareas se inscriben propiamente en las etapas del proceso de modelación matemática. En dicha situación se incorpora una herramienta tecnológica con el propósito de favorecer el tránsito entre el planteamiento del problema y la generación de modelos matemáticos.

  9. Formación continua del profesorado, investigación educativa e innovación en la enseñanza de las ciencias

    Directory of Open Access Journals (Sweden)

    Jenaro Guisasola

    2001-01-01

    Full Text Available Este trabajo surge de las actividades en Formación Continua del profesorado que hemosdesarrollado durante un período entre los 5 y 10 últimos diez años en el País Vasco y Cantabriaa través del Departamento de Educación del País Vasco y del Centro de Profesores y Recursosde Camargo (Cantabria. Las actividades de formación realizadas han sido fundamentadas en elcuerpo teórico de la Didáctica de las Ciencias, de forma que no fueran un conjunto de cursosinconexos y sin relación con la problemática del aula. Una de las conclusiones del análisis delas experiencias realizadas es la importancia de que los profesores participen de forma conti-nuada en grupos de trabajo y reflexión sobre su práctica docente y, que este trabajo sea apoya-do por tutores y por la administración educativa.

  10. Caracterización de arritmias cardíacas tras el uso de infusiones analgésicas continuas de tramadol o lidocaína en perras ovariohisterectomizadas

    OpenAIRE

    Buriticá Gaviria, Edwin Fernando; Echeverry Bonilla, Diego Fernando; Arévalo Carbonell, Mario Fernando; Alvarado Poveda, Ana María; Ospina-Argüelles, Diego Alejandro

    2017-01-01

    Resumen El uso de infusiones analgésicas continuas (IACs) es una estrategia eficaz para el control del dolor posquirúrgico en caninos; sin embargo, dependiendo del fármaco empleado, la electrofisiología cardiaca puede verse alterada por la presencia de taquiarritmias, bradiarritmias, complejos ventriculares, fibrilación o bloqueos atrioventriculares. El objetivo de este estudio fue valorar la frecuencia cardiaca y caracterizar las anormalidades electrocardiográficas observadas durante el empl...

  11. The importance of Thermo-Hydro-Mechanical couplings and microstructure to strain localization in 3D continua with application to seismic faults. Part I: Theory and linear stability analysis

    Science.gov (United States)

    Rattez, Hadrien; Stefanou, Ioannis; Sulem, Jean

    2018-06-01

    A Thermo-Hydro-Mechanical (THM) model for Cosserat continua is developed to explore the influence of frictional heating and thermal pore fluid pressurization on the strain localization phenomenon. A general framework is presented to conduct a bifurcation analysis for elasto-plastic Cosserat continua with THM couplings and predict the onset of instability. The presence of internal lengths in Cosserat continua enables to estimate the thickness of the localization zone. This is done by performing a linear stability analysis of the system and looking for the selected wavelength corresponding to the instability mode with fastest finite growth coefficient. These concepts are applied to the study of fault zones under fast shearing. For doing so, we consider a model of a sheared saturated infinite granular layer. The influence of THM couplings on the bifurcation state and the shear band width is investigated. Taking representative parameters for a centroidal fault gouge, the evolution of the thickness of the localized zone under continuous shear is studied. Furthermore, the effect of grain crushing inside the shear band is explored by varying the internal length of the constitutive law.

  12. El perfil profesional de los formadores de formación continua en España. [The professional profile of trainers working in continuous training in Spain].

    Directory of Open Access Journals (Sweden)

    Mamaqi, Xhevrie

    2011-04-01

    Full Text Available The aim of this study is to analyze and describe the professional profile of trainers working in continuous training in Spain. For this purpose we have developed a structured questionnaire was applied in person to a sample of 606 instructors nationwide. The questionnaire has provided information on aspects such as the socio-occupational status of instructors, their degree of professionalism, and the importance of professional skills. The information gathered has been analyzed by multivariate methods to determine the dominant professional profiles. The quantitative analysis includes the Categorical of Principal Components Analysis (CATPCA to analyze the skills and capabilities of the trainer and cluster analysis in two stages to get the profiles. Four dominant profiles have been deduced by the cluster analysis. The occupational variables, professional experience profiles and competences/skills produce the major discrepancies between the four profiles. El objetivo de este trabajo es analizar y describir los perfiles profesionales del formador de formación continua en España. Con este propósito se ha elaborado un cuestionario estructurado que se ha aplicado de forma presencial a una muestra de 606 formadores a nivel nacional. El cuestionario ha proporcionado información sobre aspectos como el estatus socio-laboral del formador, el grado de profesionalización y la importancia de las competencias profesionales de los formadores. La información recabada ha sido analizada mediante métodos multivariantes para determinar los perfiles profesionales dominantes. El análisis cuantitativo incluye el Análisis de Componentes Principales Categóricos (CATPCA para analizar las competencias y capacidades del formador y el análisis Cluster en Dos Fases para obtener los perfiles. De los resultados obtenidos se han deducido cuatro perfiles profesionales dominantes siendo las variables ocupacionales, experiencia profesional y de las capacidades las que mayor

  13. The self- and foreign-absorption continua of water vapor by cavity ring-down spectroscopy near 2.35 μm.

    Science.gov (United States)

    Mondelain, D; Vasilchenko, S; Čermák, P; Kassi, S; Campargue, A

    2015-07-21

    The room temperature self- and foreign-continua of water vapor have been measured near 4250 cm(-1) with a newly developed high sensitivity cavity ring down spectrometer (CRDS). The typical sensitivity of the recordings is αmin≈ 6 × 10(-10) cm(-1) which is two orders of magnitude better than previous Fourier transform spectroscopy (FTS) measurements in the spectral region. The investigated spectral interval is located in the low energy range of the important 2.1 μm atmospheric transparency window. Self-continuum cross-sections, CS, were retrieved from the quadratic dependence of the spectrum base line level measured for different water vapor pressures between 0 and 15 Torr, after subtraction of the local water monomer lines contribution calculated using HITRAN2012 line parameters. The CS values were determined with 5% accuracy for four spectral points between 4249.2 and 4257.3 cm(-1). Their values of about 3.2 × 10(-23) cm(2) molecule(-1) atm(-1) are found 20% higher than predicted by the MT_CKD V2.5 model but two times weaker than reported in the literature using FTS. The foreign-continuum was evaluated by injecting various amounts of synthetic air in the CRDS cell while keeping the initial water vapor partial pressure constant. The foreign-continuum cross-section, CF, was retrieved from a linear fit of the spectrum base line level versus the air pressure. The obtained CF values are larger by a factor of 4.5 compared to the MT_CKD values and smaller by a factor of 1.7 compared to previous FTS values. As a result, for an atmosphere at room temperature with 60% relative humidity, the foreign-continuum contribution to the water continuum near 4250 cm(-1) is found to be on the same order as the self-continuum contribution.

  14. Formación de porosidad durante la soldadura láser de Nd: YAG de onda continua en aleaciones de aluminio para aplicaciones automotrices

    Directory of Open Access Journals (Sweden)

    Pastor, Mario

    2000-04-01

    Full Text Available Pore formation is an important concern in laser welding of automotive aluminum alloys. This paper investigates the influence of the laser beam defocusing on pore formation during continuous wave Nd: YAG laser welding of aluminum automotive alloys 5182 and 5754. It was found that the instability of the keyhole during welding was a dominant cause of pore formation while hydrogen rejection played an insignificant role. The defocusing of the laser beam greatly affected the stability of the keyhole. Finally, the mechanism of the collapse of the keyhole and pore formation is proposed.

    La formación de poros es un aspecto de gran preocupación durante la soldadura láser de aleaciones de aluminio. En este trabajo se ha investigado la influencia del desenfoque del haz del láser sobre la formación de poros durante la soldadura láser (Nd: YAG de onda continua de las aleaciones de aluminio 5182 y 5754, las mismas que se usan en aplicaciones automotrices. Los resultados obtenidos indicaron que la causa dominante de formación de poros fue la inestabilidad de la cavidad de vapor o keyhole mientras que la influencia del hidrógeno fue prácticamente insignificante. El grado de desenfoque del láser tuvo gran influencia sobre la inestabilidad de la cavidad de vapor. Finalmente, en este artículo se propone el mecanismo de formación de poros a causa del colapso de la cavidad de vapor (keyhole.

  15. Predictors of outcomes and refractoriness in status epilepticus: A prospective study.

    Science.gov (United States)

    Atmaca, Murat Mert; Bebek, Nerses; Baykan, Betül; Gökyiğit, Ayşen; Gürses, Candan

    2017-10-01

    The objective of this study was to determine the predictors of outcomes and refractoriness in status epilepticus (SE). This is a prospective study of 59 adult patients with SE who were admitted to the Emergency Department between February 2012 and December 2013. The effects of clinical, demographic, and electrophysiologic features of patients with SE were evaluated. To evaluate outcome in SE, STESS, mSTESS, and EMSE scales were used. Logistic regression analysis showed that being aged ≥65years (p=0.02, OR: 17.68, 95% CI: [1.6-198.4]) for the short term and having potentially fatal etiology (p=0.027, OR: 11.7, 95% CI: [1.3-103]) for the long term were the only independent predictors of poor outcomes; whereas, the presence of periodic epileptiform discharges (PEDs) in EEG was the only independent predictor of refractoriness (p=0.032, OR: 13.7, 95% CI: [1.3-148.5]). The patients with ≥3 Status Epilepticus Severity Score (STESS) did not have poorer outcomes in the short- (p=0.157) and long term (p=0.065). There was no difference between patients with 0-2, 3-4, and ≥4 mSTESS in the short- and long term in terms of outcome (p=0.28 and 0.063, respectively). Also, there was no difference between subgroups (convulsive SE [CSE], nonconvulsive SE [NCSE], and epilepsia partialis continua [EPC]) in terms of STESS and mSTESS. When patients with EPC were excluded, both STESS and mSTESS scores of the patients correlated with poorer long-term outcomes (p=0.025 and 0.017, respectively). The patients with ≥64 points in the Epidemiology-based Mortality in SE-Etiology, age, comorbidity, EEG (EMSE-EACE) score and those with ≥27 points in EMSE-Etiology, age, comorbidity (EMSE-EAC) score did not have poorer outcomes in the short term (p=0.06 and 0.274, respectively) while they had significantly poorer outcome in the long term (pStatus epilepticus was terminated with intravenous (IV) levetiracetam (LEV) in 68.75% of patients and with IV phenytoin (PHT) in 83.3% of patients. No

  16. Reconstructing Topological Graphs and Continua

    OpenAIRE

    Gartside, Paul; Pitz, Max F.; Suabedissen, Rolf

    2015-01-01

    The deck of a topological space $X$ is the set $\\mathcal{D}(X)=\\{[X \\setminus \\{x\\}] \\colon x \\in X\\}$, where $[Z]$ denotes the homeomorphism class of $Z$. A space $X$ is topologically reconstructible if whenever $\\mathcal{D}(X)=\\mathcal{D}(Y)$ then $X$ is homeomorphic to $Y$. It is shown that all metrizable compact connected spaces are reconstructible. It follows that all finite graphs, when viewed as a 1-dimensional cell-complex, are reconstructible in the topological sense, and more genera...

  17. Wave dynamics of generalized continua

    CERN Document Server

    Bagdoev, Alexander G; Shekoyan, Ashot V

    2016-01-01

    This monograph is devoted to problems of propagation and stability of linear and nonlinear waves in continuous media with complex structure. It considers the different media, such as solid with cavities, preliminary deformed disperse medium, solid with porosity filled by the electrically conductive and non-conductive liquid, magnetoelastic, piezo-semiconductors, crystals with dislocations, composites with inclusions, an electrically conductive asymmetrical liquid, a mixture of gas with a drop liquid. The book also considers the propagation of a laser beam through a two-level medium. The presented results are based on methods of evolution and modulation equations that were developed by the authors. The book is intended for scientific and technical researchers, students and post-graduate students specializing in mechanics of continuous media, physical acoustics, and physics of the solid state.

  18. Caracterización instrumental del desplazamiento forzado en Colombia: hechos estilizados y la Encuesta Continua de Hogares (2001-2006

    Directory of Open Access Journals (Sweden)

    Adriana Carolina Silva Arias

    2008-01-01

    Full Text Available Como una alternativa a la problemática que gira en torno a la dimensión real del desplazamiento forzado en Colombia, este artículo analiza el poder explicativo de la caracterización instrumental del desplazamiento forzado a partir de la Encuesta Continua de Hogares (ECH como un sistema alternativo de información. Este estudio gira en torno a la capacidad que tendría laECHde replicar, a nivel de microdatos, algunos patrones recurrentes detectados en múltiples estudios a comunidades desplazadas. Para esto, evaluamos algunos elementos particulares de la población desplazada, tales como su nivel educativo, patrones de género, tamaño y tasas de dependencia de las familias desplazadas, así como patrones de inserción laboral. En general, la caracterización del desplazamiento forzado a través de laECHpara el periodo 2001-2006, refleja patrones identificados en la literatura sobre el desplazamiento en Colombia; presenta perfiles empíricos similares a los encontrados en estudios muestrales y en sistemas de información sobre desplazamiento forzado. Adicionalmente, este sistema de información exhibe comportamientos diferenciales entre los migrantes económicos voluntarios e individuos desplazados (IDPs - Internally Displaced Individuals acorde con el análisis teórico de selección del migrante postulado por Borjas (1982. De esta manera, se evidenció entre los desplazados una alta proporción de menores de edad, así como una alta tasa de dependencia económica; además una dimensión de género ligada a la descomposición familiar, debido a que se encontró mayor proporción de hogares desplazados con jefatura femenina, así como mayor proporción de viudas, siendo las mujeres las que devengaron menores ingresos. El tratamiento empírico ofrece dos conclusiones destacables. La primera de ellas es reforzar la existencia de ciertos hechos estilizados en el perfil de los desplazados forzados en Colombia. La segunda es que la caracterizaci

  19. Análisis comparativo de dos métodos docentes en la geología aplicada a la ingeniería. Trabajos, adquisición de competencias y evaluación continua

    OpenAIRE

    Huerta Hurtado, Pedro; Rodríguez Bouzo, Loreto; Silva Barroso, Pablo Gabriel; Reguilón Bragado, Rosa María

    2010-01-01

    Memoria ID-0083. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2009-2010. La aplicación de nuevas metodologías docentes enfocadas a la adquisición de las competencias específicas y transversales supone un desarrollo pragmático de las asignaturas. Los trabajos de asignatura y la evaluación continua son dos metodologías de gran utilidad a la hora de aplicar la filosofía del Espacio Europeo de Educación Superior (EEES) a las Ingenierías. Este proyecto desarrolla dich...

  20. Propuesta de un Modelo de Mejora Continua en los Procesos del Laboratorio Ambiental Ipsomary s.a Basado en un Sistema de Gestión de Calidad Bajo la Norma ISO 9001:2008

    OpenAIRE

    Zambrano Carrillo, Carolina; Rodríguez Portés, Sergio

    2013-01-01

    El presente estudio se realizó en la empresa privada Ipsomary S.A con el objetivo principal de elaborar un modelo de mejora continua de sus procesos que permita incrementar la eficacia del sistema de gestión de calidad empleando una gestión eficiente de sus procesos para asegurar la satisfacción de sus clientes El estudio está compuesto de una investigación del mercado de servicios ambientales, determinación de la situación actual de la organización, evaluación en relación a los requisitos de...

  1. Modelo de gestión de calidad a través de la mejora continua en la manufactura de transformadores de distribución y potencia

    OpenAIRE

    Ramos Carrión, Jorge Carmelo

    2017-01-01

    Enfoca la problemática de la calidad en los procesos de manufactura de transformadores de distribución y potencia, proponiendo un modelo de gestión de calidad a través de la mejora continua. Este modelo se construye tomando como referencia el estado real de los procesos y se valida aplicándolo a un grupo de empresas constituido por una gran empresa, una mediana empresa y dos pequeñas empresas, fabricantes de máquinas eléctricas, ubicadas en la ciudad de Lima. El modelo de gestión de calidad s...

  2. Towards minimum energy houses with EPC {<=}0; Op weg naar minimum energie woningen met EPC {<=}0

    Energy Technology Data Exchange (ETDEWEB)

    Den Dulk, F.W. [Piode - ontwerp- en adviesbureau BNA, Amersfoort (Netherlands)

    2012-09-15

    The purpose of the publication is to inform stakeholders about the current state concerning energy efficient building of houses and residential buildings. Also guidance is provided with regard to steps to follow and some practical examples are given. The energy concepts shown are based on known and marketable techniques. An energy concept is a balanced and tailored set of design measures, building construction facilities, installation and (sustainable) energy supply. Optimization is based on energy savings and costs and benefits and it must also meet requirements for health, safety, comfort and ease of operation [Dutch] Het doel van de publicatie is om belanghebbenden te informeren over de huidige stand van zaken m.b.t. vergaand energiezuinig bouwen. Tevens wordt een handreiking geboden over de te volgen stappen en zijn een aantal voorbeelden opgenomen over de praktijk. De publicatie is beperkt tot seriematige woningbouw. De energieconcepten zijn op het niveau van de individuele woning of een woongebouw. De weergegeven energieconcepten zijn gebaseerd op bekende- en marktrijpe technieken. Een energieconcept is een afgewogen en op elkaar afgestemd samenstel van ontwerpmaatregelen, bouwkundige maatregelen en voorzieningen, de installatie en de (duurzame) energievoorziening . Optimalisatie vindt plaats op basis van energiebesparing en kosten/baten terwijl tevens moet worden voldaan aan eisen voor veiligheid, gezondheid, comfort en bedieningsgemak.

  3. Modeling the effect of the seismic wave propagation in buried continuous pipelines; Modelacion del efecto de propagacion de ondas sismicas en tuberias continuas enterradas

    Energy Technology Data Exchange (ETDEWEB)

    Melchor Garcia, Nicolas Ageo

    2005-02-15

    -tuberia. Algunos modelos analiticos son presentados y discutidos con gran detalle. Se trata de contribuir en particular en los siguientes aspectos: Primero, intenta ser un trabajo de referencia para los ingenieros geotecnistas que se enfrentan a problemas relacionados con el fenomeno propagacion de ondas sismicas en estructuras enterradas o problemas afines, ya que dentro de la literatura consultada existen muchos principios aqui presentados que estan relacionados con la ingenieria sismica, el modulo de reaccion, asi como tambien con expresiones o investigaciones realizadas en pilotes. Segundo, se presenta un modelo numerico cuasiestatico que analiza la tuberia continua a traves de un vector de fuerzas de tipo senoidal. El analisis de los esfuerzos y deformaciones que le transmite el suelo a la tuberia se hace utilizando un modelo de interaccion suelo-tuberia. Para un nivel bajo de deformaciones se considera un comportamiento de transferencia elastico en la interfaz suelo-tuberia. En el caso de deformaciones mayores se supone que se presenta deslizamiento debido a que el suelo circundante presenta falla por cortante en el suelo que lo rodea. El analisis cubre unicamente el caso de deformaciones axiales en tramos rectos. Finalmente, intenta dar una serie de recomendaciones para futuros trabajos de investigacion sobre la modelacion de tuberias enterradas. En este trabajo, la influencia de varios aspectos sobre la respuesta de tuberias a la propagacion de ondas sismicas es analizada y discutida; tales como las condiciones de topografia, geologia, estratigrafia del suelo y los cambios de rigidez en el suelo que se encuentra alrededor de la tuberia.

  4. Avaliação da concentração expirada de isoflurano em infusão continua de remifentanil em cadelas submetidas a mastectomia

    Directory of Open Access Journals (Sweden)

    Suzane Lilian Beier

    2015-10-01

    Full Text Available Os objetivos deste estudo são a avaliação dos efeitos de duas taxas fixas de infusão continua de remifentanil na concentração expirada de isoflurano (ETiso em cadelas submetidas à mastectomia. Foram utilizadas 18 cadelas, 12+2 anos de idade e pesando 15+5 Kg. Os animais foram distribuídos aleatoriamente em 3 grupos (n=6/grupo e submetidos à mastectomia unilateral devido a neoplasia mamária. Todos os animais foram pré-medicados com morfina (0,5 mg Kg-1 e acepromazina (0,03 mg Kg-1, ambas por via intramuscular (IM. A indução da anestesia foi realizada com propofol (dose-efeito. Os animais foram intubados e conectados a um sistema circular com reinalação de gases. Foi utilizada ventilação com pressão positiva intermitente para manutenção de normocapnia com fluxo de oxigênio de 2 L/min e FiO2 de 100%. A anestesia foi mantida com isoflurano e solução salina (grupo controle [GCON], n=6 ou infusão intravenosa de remifentanil na taxa de 0,15 ?g Kg-1min-1 (REMI 0,15 n=6 ou 0,3 ?g Kg-1min-1 (REMI 0,3 n=6. As variáveis cardiovasculares e a ETiso foram monitoradas antes e a cada 15 minutos após o início da cirurgia. Os dados foram analisados por ANOVA com repetições múltiplas para comparações entre momentos e ANOVA seguida de teste Student Newman Keuls (p£0.05 para comparações entre grupos. A frequência cardíaca foi menor em todos os momentos nos grupos REMI 0,15 e REMI 0,3 em comparação com GCON, sendo que não foram encontradas diferenças estatísticas para essa variável entre os dois grupos com infusão de remifentanil. Adicionalmente, os valores de pressão arterial (PAS, PAM e PAD não apresentaram diferenças entre grupos. Os valores basais (antes da cirurgia de ETiso não apresentaram diferenças entre os 3 grupos. Após o início da cirurgia, a ETiso variou entre 1,37±0,3 e 1,05±0,19 no grupo controle; nos grupos REMI 0,15 e REMI 0,3 a ETiso foi 36,5% e 65,7% menor que no grupo controle (M15. A infusão de

  5. Optimización simultánea para la mejora continua y reducción de costos en procesos Optimización simultánea para la mejora continua y reducción de costos en procesos

    Directory of Open Access Journals (Sweden)

    Jorge Domínguez Domínguez

    2006-12-01

    Full Text Available Muchos problemas de optimización son caracterizados por la flexibilidad para establecer la utilidad entre las funciones objetivo. La estrategia experimental desempeña un papel importante para generar estas funciones objetivo, además, ésta se ha aplicado de manera conveniente para disminuir costos de calidad y en la mejora continua de la calidad de procesos y productos. Es frecuente encontrar muchas aplicaciones industriales con varias respuestas cuya finalidad es alcanzar la calidad global de un producto, por lo que es necesario optimizar de manera simultánea las respuestas de interés. En esencia, el problema de optimización de varias respuestas involucra la selección de un conjunto de condiciones o variables independientes tales que den como resultado un producto o servicio adecuado. Es decir, se desea seleccionar los niveles de las variables independientes que optimicen todas las respuestas a la vez. En esta presentación se mostrarán dos procedimientos para construir una función que describa la combinación de los objetivos de las respuestas individuales. El primer método es un modelo de optimización multiplicativo y el segundo es aditivo, estos se aplicarán a dos casos de estudio realizados en la industria con el fin de resaltar los procesos de mejora continua y la disminución de costos. La optimización simultánea, utilizando estos dos procedimientos, se ilustrarán mediante técnicas de graficación ya que éstas permiten generar varios escenarios de posibles soluciones óptimas. En estos ejemplos se observó que ambos métodos producen resultados similares al generar el óptimo, sin embargo al compararlos de manera global mediante la función de pérdida existe una ligera diferencia entre ellos.Many problems of optimization are characterized by the flexibility to establish the utility among the functions objectives. Experimental strategy plays a very important part for generating theses functions. This specific strategy

  6. Análisis comparativo de modelos hidrológicos de simulación continua en cuencas de alta montaña: caso del Río Chinchiná

    OpenAIRE

    Ocampo, Olga Lucía; Universidad Autónoma de Manizales; Vélez, Jorge Julián; Universidad Nacional de Colombia sede Manizales

    2014-01-01

    La modelación hidrológica es la base para la gestión integral del recurso hídrico; en cuencas de alta montaña, e involucra una compleja interacción de procesos físicoquímicos. Este estudio, realizado en la cuenca del río Chinchiná, Colombia, plantea un análisis multimodelo para capturar la incertidumbre asociada con la modelación hidrológica, mediante la aplicación de siete modelos hidrológicos, lluvia-escorrentía de simulación continua, agregados a escala mensual, con diferentes niveles de c...

  7. Análisis, desarrollo e implementación del modelo de mejora continua GM-Difference para el aseguramiento de la calidad en las áreas de venta y posventa de Automotores Continental S. A.

    OpenAIRE

    Gálvez Gálvez, Eduardo Vinicio; Proaño Jaramillo, Pablo Miguel

    2014-01-01

    Este proyecto trata sobre el Análisis, Desarrollo e Implementación de un modelo de mejora continua para lograr el aseguramiento de la Calidad Total en las áreas de venta y posventa de Automotores Continental S.A., a partir de la aplicación de estándares de calidad GM Difference. Para ello, primero se hizo un diagnóstico de la Situación Actual, basados en el estudio a una muestra de 138 clientes, los cuales, a través del análisis de Diagrama de Pareto, Esquematización Causa-Efecto y Matriz de ...

  8. Enablers and inhibitors for sustainability of continuous improvement: A study in the automotive industry suppliers in the Valencia Region Facilitadores y barreras para la sostenibilidad de la mejora continua: Un estudio en proveedores del automóvil de la Comunidad Valenciana

    Directory of Open Access Journals (Sweden)

    Juan A. Marin-Garcia

    2009-04-01

    Full Text Available In recent years it has been widely discussed the use of continuous improvement in all kind of business and particularly in companies belonging to the automotive industry. Many authors mention improvements, in key indicators of production through the use of continuous improvement tools. At the same time, different authors talk about how to sustain the continuous improvement over time, and try to identify inhibitors and enablers for the sustainability of continuous improvement. But despite this, one can still find first tier suppliers in the automotive industry which have not implemented systems of continuous improvement. This study aims to identify, classify, prioritize and discuss the different enablers and inhibitors which can be found in automotive suppliers companies. For that reason some interviews were conducted with first tier suppliers in the automotive industry that have succeeded or failed in implementing continuous improvement. We have tried to understand better the problems for the implementation and sustainability of continuous improvement.En los últimos años se ha descrito ampliamente el uso de la mejora continua en todo tipo de empresas y fundamentalmente, en las empresas pertenecientes al sector del automóvil. Muchos autores citan las mejoras de los principales indicadores productivos a través del uso de herramientas de mejora continua. Al mismo tiempo, diferentes autores hablan de cómo poder sostener dicha mejora continua a través del tiempo y tratan de identificar barreras y facilitadores para la sostenibilidad de la mejora continua. Pero, a pesar de ello, se pueden encontrar proveedores de primer nivel del sector del automóvil que no tienen implantados sistemas de mejora continua. El presente estudio tiene por objeto identificar clasificar y priorizar las diferentes barreras y facilitadores que se pueden encontrar en las empresas proveedoras de la industria del automóvil. Para ello se han realizado entrevistas con

  9. Comportamiento de los trabajadores a tiempo parcial desde una perspectiva dinámica: Un análisis para España con datos de la Muestra Continua de Vidas Laborales 2005

    Directory of Open Access Journals (Sweden)

    Pablo de Pedraza

    2008-07-01

    Full Text Available Este trabajo tiene como objetivo estudiar las transiciones laborales de los trabajadores a tiempo parcial en España. Para ello, en una primera sección se repasa la literatura existente más relevante para el caso español. En segundo lugar, partiendo de una submuestra de la Muestra Continua de Vidas Laborales 2005b de la Seguridad Social formada por aquellos con algún contrato a tiempo parcial en 2001, se estudian las distintas trayectorias laborales desde 2001 hasta 2005. Ese análisis permite identificar cinco categorías diferentes según hayan seguido trabajando a tiempo parcial, hayan pasado al tiempo completo, al no empleo, a la inactividad o hayan firmado más de un determinado número de contratos. Finalmente, se estiman las probabilidades de encontrarse en uno u otro grupo utilizando como variables explicativas una serie de características del sujeto como el sexo, la edad y la categoría profesional y del sector de trabajo.

  10. Degradación de los módulos elásticos transversal y de cortadura en materiales compuestos con refuerzo de fibra continua de carbono sometidos a fatiga

    Directory of Open Access Journals (Sweden)

    Revuelta, D.

    2004-04-01

    Full Text Available Fatigue failure in continuous fiber composite materials is caused in first place by matrix cracks that propagate along the fiber direction. It is expected that the defined crack orientation produced an anisotropic degradation of the laminate elastic properties. This work characterizes the degradation suffered by the transverse elastic modulus of a graphite-epoxy laminate subjected to fatigue loads, concluding that the elastic modulus changes drastically from a determined damage threshold, decaying according to a quadratic law.

    La rotura a fatiga en materiales compuestos con refuerzo de fibra continua es debida en primera instancia a la aparición de grietas en la matriz que se propagan en la dirección paralela a la fibra. Es de esperar que la orientación definida de estas grietas produzca una degradación anisótropa de las propiedades elásticas de la lámina. Este trabajo caracteriza la degradación que experimenta el módulo elástico en la dirección perpendicular a la fibra de un material compuesto grafito-epoxi sometido a cargas de fatiga, hallándose que el módulo elástico sufre cambios drásticos a partir de un determinado umbral de daño, y decayendo a partir de ese punto según una ley cuadrática.

  11. Impacto de la capacitación en la mejora continua de la calidad del diagnóstico citológico The effect of technical training for the continuous improvement of the quality in cytological diagnosis

    Directory of Open Access Journals (Sweden)

    Miguel Angel Herrera Pérez

    2010-03-01

    Full Text Available Los indicadores generales de la eficacia en los programas de prevención del cáncer cervical se mantienen altos en nuestro país. Objetivos: Evaluar el impacto de la capacitación técnica en la mejora continua del diagnóstico citológico del cuello uterino en el Hospital "Abel Santamaría Cuadrado", período 2005-2007. Diseño: Se realizó un estudio de intervención-acción para medir el efecto de la capacitación en la calidad del diagnóstico de los citotecnólogos, medido mediante la correlación entre un primer diagnóstico emitido por el personal técnico y un segundo por un especialista en Anatomía Patológica, de una muestra de 22864 citologías. Se utilizaron las variables de concordancia en general y por el tipo de lesión, y aplicó la estadística descriptiva para variables cualitativas categóricas, expresadas en frecuencias absolutas y relativas porcentuales. Las comparaciones de frecuencias se verificaron mediante el estadígrafo de Ji cuadrado al 95 % de confianza y la prueba de kappa para la correlación entre observadores. Resultados. Se encontró un incremento de la concordancia en el 2007 con relación al periodo 2005-2006, resultado altamente significativo (X² = 75.0; gdl = 1; p = 0.00000001. La concordancia de acuerdo al diagnóstico se incrementó con la excepción del NIC-III. Conclusión. Se comprobó que la capacitación influyó en la mejoría continua de la calidad del diagnóstico citológico.In our country general indicators to assess the effectiveness of Programs for the Prevention of Cervical Cancer keep high. Objectives: To evaluate the effects of the technical training for the continuous improvement of cytological diagnosis of the cervical cancer at "Abel Santamaria Cuadrado" University Hospital, during 2005-2007. Design: An intervention-action research was conducted in order to assess the effectiveness of the technical training process for improving quality in the diagnosis performed by the technicians of

  12. Revisión del proceso siderúrgico de colada continua mediante solidificación rápida. Sistema de dos cilindros de colada conformación

    Directory of Open Access Journals (Sweden)

    Ibarrondo, I.

    2008-12-01

    Full Text Available In order to compete in the future steel market and to maintain market share, the steelmakers will need to use new efficient technologies capable of supplying steel strip products of high quality at low cost. In this way, the strip casting technology by twin roll method is one of the most important research area in the iron and steel industry today.This review makes a general description of the strip casting technology as well as its different steps, such us; metal delivery and casting, solidification process, hot rolling reduction step, etc...Through mathematical and physical models, the influence on microstructure, texture, surface quality and mechanical properties of the materials obtained by this method are described as a function of processing parameters, specially the roughness of the rolls.The manufacturing of carbon, stainless and electrical steels involves smaller capital and operating cost, lower gas emissions, and an opportunity to create new grades due to a faster solidification rate that leads to a different solidification structures.In sight of all this it is likely that Strip Casting technology will make a profound impact on the manufacturing landscape of the 21st century.

    A la vista de la evolución del mercado siderúrgico mundial, se hace evidente que las instalaciones siderúrgicas deberán desarrollar nuevos procesos siderúrgicos, capaces de producir productos de alta calidad y valor añadido, con menores inversiones de capital, ahorro energético y disminución de emisiones contaminantes. Dentro de este contexto, la tecnología de colada continua por solidificación rápida mediante dos cilindros, se presenta como una de las más interesantes a investigar. En el presente trabajo se realiza una descripción general del proceso de colada continua mediante solidificación rápida así como de sus diferentes etapas; alimentación del sistema y colada, proceso solidificación, etapa de laminación en caliente

  13. ¿Cuánto nos importa la clase energética de nuestras viviendas? un análisis del nivel de comprensión de los EPC, disposición y motivos de pago en Barcelona.

    Directory of Open Access Journals (Sweden)

    Carlos Marmolejo Duarte

    2017-06-01

    Full Text Available Se reportan los resultados de una investigación pionera en España cuyos objetivos son: analizar el nivel de comprensión de las certificaciones energéticas EPC por parte de los hogares, evaluar la confianza percibida y la disposición a pagar (DAP por viviendas energéticamente cualificadas. Mediante una valoración contingente se extrae la DAP por mejorar la calificación de un apartamento tipo en Barcelona. En general, los respondientes desconocen los elementos que determinan la calificación energética, especialmente los menos formados y mayores. Asimismo, prefieren unidades de consumo y emisiones comprensibles. Esto produce una desconfianza del certificado e incide en una infravaloración de las viviendas energéticamente calificadas. La DAP por la mejora E->A se sitúa en 30,58 euros/mes e iguala el ahorro en la factura energética ofrecido. Detrás de la DAP subyacen razones financieras, como los ingresos o el ahorro energético, pero también la sensibilidad medioambiental y el consumo responsable. Finalmente, las personas que prefieren comprar en lugar de alquilar parecen estar DAP más por una mejor calificación. Todo ello constituye un mensaje claro para la política energética. Este artículo se deriva del proyecto BIA2015-63606-R (MINECO/FEDER: EnerVALOR ¿Cuánto nos importa la calificación energética? 

  14. Generación de inclusiones no metálicas y su efecto sobre el bloqueo de boquillas de colada continua en aceros ultra bajo carbono estabilizados con titanio

    Directory of Open Access Journals (Sweden)

    Vega-Becerra, O.

    2005-12-01

    Full Text Available This work presents a thermodynamic and experimental analysis of the phases that precipitate in the non metallic inclusions depending on the contents of aluminium (Al, titanium (Ti and oxygen (O in the steel, and their influence on the nozzle clogging. For the thermodynamic analysis, the program FACT WIN (Facility For The Analysis of Chemical Thermodynamics subroutine Equilib. was used. The experimental tests were carried out in an TAMMANN furnace, in an argon atmosphere. The control of the content of dissolved oxygen was carried out by means of sensors of solid electrolyte bases zirconia. The characterization of the inclusions was carried out with SEM, EDS and by means of the technique of fractional reduction with carbon. A good agreement was observed between the thermodynamic predictions and the experimental results.

    En este trabajo se presenta un análisis termodinámico y experimental de las fases que precipitan en inclusiones no metálicas en función de los contenidos de aluminio (Al, titanio (Ti y oxígeno (O en el acero y su influencia sobre el bloqueo de boquillas de colada continua. Para el análisis termodinámico se utilizó el programa FACT-WIN (Facility For The Analysis of Chemical Thermodynamics subrutina Equilib. Las pruebas experimentales se realizaron en un horno TAMMANN, en atmósfera de argón. El control del contenido de oxígeno disuelto se llevó a cabo mediante sensores de electrólito sólido base zirconia. La caracterización de las inclusiones se realizó por SEM, EDS y mediante la técnica de reducción fraccionada con carbono. Se observó una buena concordancia entre las predicciones termodinámicas y los resultados experimentales.

  15. Proceedings of the Third Environmental Physics Conference (EPC-2008)

    International Nuclear Information System (INIS)

    Comsan, M.N.H.

    2009-01-01

    The publication has been set up as proceedings of the environmental physics conference. the conference consistes of atmospere and climate; the ecosystem; radiation and radioactivity; activity review; environmental issues. This conference consistes of 335p., figs., tabs., refs.

  16. Proceedings of the Second Environmental Physics Conference (EPC-2006)

    International Nuclear Information System (INIS)

    Comsan, M.N.H.

    2007-01-01

    The publication has been set up as proceedings of the environmental physics conference. the conference consistes of atmospere and climate; the ecosystem; radiation and radioactivity; activity review; environmental issues. This conference consistes of 247p., figs., tabs., refs

  17. Proceedings of the First Environmental Physics Conference (EPC-2004)

    International Nuclear Information System (INIS)

    2005-01-01

    The publication has been set up as proceedings of the environmental physics conference. the conference consistes of environmental monitoring, the Eco system, natural radioactivity, hazards and risks, activity reviews, environmental mangement. this conference consistes of 252p., figs., tabs., refrs

  18. How EPC firms can enter the nuclear renaissance

    OpenAIRE

    Locatelli, Giorgio; Mancini, Mauro

    2012-01-01

    the so called “nuclear renaissance” is creating a millionaire market for new nuclear reactors. Few firms have the capabilities to work in this complex and highly demanding market, whereas many other are investigating the option to enter. Quite surprising the international scientific literature provides information regarding the high-level governmental aspects of nuclear power programs in different countries while the analysis at firm level is almost inexistent. Moreover the usual business mod...

  19. Exploiting phase measurements of EPC Gen2 RFID tags

    NARCIS (Netherlands)

    Huiting, J.; Flisijn, Hubert; Kokkeler, Andre B.J.; Smit, Gerardus Johannes Maria

    2013-01-01

    This paper presents a 2d localization system for UHF RFID tags. By measuring the phase between the transmitted continuous wave and received backscatter from the tag at different frequencies, it is possible to estimate the distance between the reader and tag. By determining distance estimates to

  20. Proceedings of the Fourth Environmental Physics Conference (EPC'10)

    International Nuclear Information System (INIS)

    Comsan, M.N.H.

    2010-01-01

    The publication has been set up as proceedings of the environmental physics conference. the conference consistes of atmospere and climate; the ecosystem; radiation and radioactivity; activity review; environmental issues. This conference consistes of 157 p., figs., tabs., refs

  1. Environmental Parametric Cost Model in Oil and Gas EPC Contracts

    Directory of Open Access Journals (Sweden)

    Madjid Abbaspour

    2018-01-01

    Full Text Available This study aims at identifying the parameters that govern the environmental costs in oil and gas projects. An initial conceptual model was proposed. Next, the costs of environmental management work packages were estimated, separately and were applied in project control tools (WBS/CBS. Then, an environmental parametric cost model was designed to determine the environmental costs and relevant weighting factors. The suggested model can be considered as an innovative approach to designate the environmental indicators in oil and gas projects. The validity of variables was investigated based on Delphi method. The results indicated that the project environmental management’s weighting factor is 0.87% of total project’s weighting factor.

  2. EPC: A Provably Secure Permutation Based Compression Function

    DEFF Research Database (Denmark)

    Bagheri, Nasour; Gauravaram, Praveen; Naderi, Majid

    2010-01-01

    The security of permutation-based hash functions in the ideal permutation model has been studied when the input-length of compression function is larger than the input-length of the permutation function. In this paper, we consider permutation based compression functions that have input lengths sh...

  3. Proceedings of the First Environmental Physics Conference (EPC-2004)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The publication has been set up as proceedings of the environmental physics conference. the conference consistes of environmental monitoring, the Eco system, natural radioactivity, hazards and risks, activity reviews, environmental mangement. this conference consistes of 252p., figs., tabs., refrs.

  4. Mathematical aspects of multi-porosity continua

    CERN Document Server

    Straughan, Brian

    2017-01-01

    This book is devoted to describing theories for porous media where such pores have an inbuilt macro structure and a micro structure. For example, a double porosity material has pores on a macro scale, but additionally there are cracks or fissures in the solid skeleton. The actual body is allowed to deform and thus the underlying theory is one of elasticity. Various different descriptions are reviewed. Chapter 1 introduces the classical linear theory of elastodynamics together with uniqueness and continuous dependence results. Chapters 2 and 3 review developments of theories for double and triple porosity using a pressure-displacement structure and also using voids-displacement. Chapter 4 compares various aspects of the pressure-displacement and voids-displacement theories via uniqueness studies and wave motion analysis. Mathematical analyses of double and triple porosity materials are included concentrating on uniqueness and stability studies in chapters 5 to 7. In chapters 8 and 9 the emphasis is on wa...

  5. Aproximación continua al grafeno

    OpenAIRE

    García Hervás, Roberto

    2016-01-01

    Este trabajo trata de un estudio de las propiedades generales y aplicaciones del grafeno haciendo una especial incidencia en sus propiedades electrónicas a bajas energías. Comienza con una introducción a este material bidimensional (capítulo 1) con el fin de familiarizarnos con él, viendo como se llegó a su descubrimiento y algunas de sus propiedades y aplicaciones. Continúa con un análisis de las propiedades de sus constituyentes, los átomos de carbono (capítulo 2), donde veremos los enlaces ...

  6. Nonlinear continua fundaments for the computational techniques

    CERN Document Server

    Dvorkin, Eduardo N

    2005-01-01

    Offers a presentation of Continuum Mechanics, oriented towards numerical applications in the nonlinear analysis of solids, structures and fluid mechanics. This book develops general curvilinear coordinator kinematics of the continuum deformation using general curvilinear coordinates.

  7. Participacion del empleado en la mejora continua

    Directory of Open Access Journals (Sweden)

    Cruz, J.

    2007-01-01

    Full Text Available In this paper we will discuss about the continuous improvement effect driven by the active employee participation. This will lead to have multiple results in innovation, problem solving and process optimization fields. We will discuss in regards of the main need of all organization to become more productive and efficient in order to promote a positive change, as well as the different alternatives that the firm can use in order to promote such change. We will propose Monozukury system and its tools like one of the most advanced system than can combine both aspects: Employee participation and positive change, both aspects supporting each other. This paper is divided in two manuscripts: The first includes a theoretical discussion about: 1 The need of change, 2 Employee satisfaction and quality culture, 3 Case of study: Automotive industry experience. The second manuscript will cover an empirical research about the cause and effect variables covered in this paper. The aim of this paper is to discuss about the employee relevant role and how it can be improved looking toward driving a positive change in all organizations.

  8. Mechanical sources in orthotropic micropolar continua

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    that Iesan (1973, 1974a, 1974b) analyzed the static problems of plane micropolar strain of a homoge- neous and orthotropic elastic solid, torsion prob- lem of homogeneous and orthotropic cylinders in the linear theory of micropolar elasticity and bend- ing of orthotropic micropolar elastic beams by ter- minals couples.

  9. Modelling of Size Effect with Regularised Continua

    Directory of Open Access Journals (Sweden)

    H. Askes

    2004-01-01

    Full Text Available A nonlocal damage continuum and a viscoplastic damage continuum are used to model size effects. Three-point bending specimens are analysed, whereby a distinction is made between unnotched specimens, specimens with a constant notch and specimens with a proportionally scaled notch. Numerical finite element simulations have been performed for specimen sizes in a range of 1:64. Size effects are established in terms of nominal strength and compared to existing size effect models from the literature. 

  10. Raquianestesia contínua em paciente submetido à gastrectomia parcial: relato de caso Raquianestesia continua en paciente sometido a la gastrectomía parcial: relato de caso Continuous spinal block in a patient undergoing partial gastrectomy: case report

    Directory of Open Access Journals (Sweden)

    Patrícia Falcão Pitombo

    2009-08-01

    ógicas, la raquianestesia continua fue abandonada durante muchos años. Con el surgimiento de los catéteres intermediarios, la técnica ha venido evolucionando nuevamente y obteniendo la simpatía en el arsenal anestesiológico. El objetivo de este relato, fue rescatar la utilidad de la técnica como una alternativa viable para el procedimiento de medio y gran porte. RELATO DEL CASO: Paciente femenina, 58 años, 62 kg, estado físico ASA I, con relato de jaqueca, lumbago y procedimientos quirúrgicos previos, bajo raquianestesia sin intercurrencias. Candidata a laparotomía exploradora por un probable tumor pélvico. Después de efectuada la venoclisis con catéter 18G, monitorización con cardioscopio, presión arterial no invasiva, y la oximetría de pulso, se le sedó con midazolam 2 mg y fentanil 100 ¼g y se le puso en decúbito lateral izquierdo. Se le sometió a la raquianestesia continua por vía mediana en L3-L4. Se le inyectaron 9 mg bupivacaína hiperbárica a 0,5% y 120 ¼g de sulfato de morfina. Después de la inspección de la cavidad, se verificó que el tumor era proveniente del estroma gástrico, siendo necesaria la ampliación de la incisión y la realización de gastrectomía parcial. Todo el procedimiento fue realizado con una pequeña dosis de solución hiperbárica y una completa estabilidad hemodinámica. No hubo necesidad de UCI en el postoperatorio y la paciente evolucionó sin quejarse y con un alto grado de satisfacción. Recibió el alta después de 72 horas sin ningún problema. CONCLUSIONES: Los catéteres intermediarios utilizados en la raquianestesia continua parecen ser promisorios en hacer con que la técnica sea bastante atractiva y de gran utilidad en operaciones de medio y gran porte, y puede incluso ser una alternativa eficaz en el manejo de pacientes en estado crítico, donde las grandes repercusiones hemodinámicas pueden ser perjudiciales.BACKGROUND AND OBJECTIVES: Due to the high incidence of technical and neurological complications

  11. Desafíos y esperanzas de un procedimiento científico terapéutico: hemodiálisis arteriovenosa continua Challenges and Hopes of a scientific therapeutic procedure: Continuous Hemodialisis

    Directory of Open Access Journals (Sweden)

    Lourdes Elena Yera Loyola

    2003-08-01

    Full Text Available Se realiza un estudio sobre las interacciones entre el contexto sociocultural, la ciencia y la tecnología en el surgimiento y desarrollo de un novedoso procedimiento científico terapéutico: La Hemodiálisis Arteriovenosa continua, así como los posibles impactos sociales, económicos y científicos que traería consigo la aplicación de esta nueva tecnología, se concluye que el desarrollo científico tecnológico alcanzado alrededor de la segunda guerra mundial, así como la alta mortalidad en heridos con Insuficiencia renal aguda jugaron un importante papel en el surgimiento de la hemodiálisis. Las ventajas económicas que ofrece la aplicación de este proceder hace muy útil su aplicación en Cuba y otros países en vías de desarrollo que no tienen acceso a las caras tecnologías capitalistas. El modelo cubano de construcción del socialismo con una visión amplia en ciencia, tecnología y sociedad, ofrece respuestas efectivas al desafío científico tecnológico que hoy enfrentan los países subdesarrolladosA study on the interactions among the sociocultural context, science and technology in the emergence and development of a novel therapeutic scientific procedure: Continuous Arteriovenous Hemodyalisis is carried out, as well as the possible social, economic and scientific impacts of the application of this new technology. It is concluded that the technological-scientific development reached around the Second World War, as well as the high mortality among wounded soldiers with acute renal insufficiency played an important role in the emergence of hemodialysis. The economic advantages that the application of this procedure offers makes very useful its application in Cuba and other developing countries that don't have access to expensive capitalist technologies. The Cuban pattern for the construction of socialism, with its wide vision of science, technology and society, offers effective answers to the technological-scientific challenge

  12. Análisis de imágenes mediante el método de los momentos usando funciones de base continuas a intervalos (PCBF

    Directory of Open Access Journals (Sweden)

    Sergio Domínguez

    2015-01-01

    Full Text Available Resumen: Los invariantes generados a partir de momentos extráıdos de una imagen aparecen recurrentemente en la bibliograf́ıa como uno de los métodos más potentes para la descripción de imágenes, y más concretamente de formas. En este art́ıculo se propone el uso de funciones de base continuas a intervalos (PCBF como alternativa a las bases que se vienen utilizando tradicionalmente en la aplicación de este método, todas ellas continas como puedan ser las muy conocidas de Zernike, Legendre o Tchebichev. El uso de funciones discontinuas se justifica en la naturaleza discontinua de los objetos analizados, en este caso las imágenes: es de sobra conocido que los contornos de los objetos visibles en ellas se caracterizan como discontinuidades en la serie de valores de luminancia cuando nos desplazamos de un lado a otro de dichos contornos. El análisis de tales señales con funciones continuas produce resultados no deseados, como el fenómeno de Gibbs, que pueden ser evitados mediante el uso de funciones como las propuestas, generando mejores aproximaciones a la forma analizada. Adicionalmente, las bases propuestas permiten fácilmente, como se demuestra, la generación de invariantes a rotación, caracteŕıstica altamente deseable para un descriptor de forma, puesto que a priori no se conoce con qué orientación aparecerá esta en la imagen objeto del análisis. La invarianza a traslación y escala se consigue mediante un sencillo proceso de normalización. Se presentan los test que confirman esta hipótesis, comenzando por un análisis del comportamiento de los invariantes ante el ruido en la imagen que permitirá determinar en qué número deben ser extráıdos. A continuación, y una vez definida esta longitud de descripción, se realizan sendos experimentos para determinar el comportamiento de los invariantes propuestos en una

  13. Functional hemispherotomy in Rasmussen syndrome in the absence of classic MRI findings

    Directory of Open Access Journals (Sweden)

    Yasunori Nagahama

    2017-01-01

    Full Text Available A 7-year-old previously healthy girl presented with a left-sided focal seizure without impaired consciousness and subsequently developed epilepsia partialis continua. Initial MRI was normal, and the subsequent images only showed a focal T2/FLAIR hyperintense area without cortical atrophy. She was diagnosed with Rasmussen syndrome by pathology and promptly treated with functional hemispherotomy. Rasmussen syndrome is a rare progressive neurological disorder, the only definitive cure for which is hemispheric disconnection. The disease presents a management dilemma, especially early in disease course without characteristic neuroimaging features. A high index of suspicion, multidisciplinary approach, and clear timely communication with the family are critical.

  14. Cultivos de alta densidad celular por retención interna: aplicación a la fermentación continua de etanol High cell density cultures produced by internal retention: application in continuous ethanol fermentation

    Directory of Open Access Journals (Sweden)

    Godoy Rubén Darío

    2004-12-01

    Full Text Available El etanol ha generado gran interés por su potencial como combustible alternativo. No obstante, para que este producto sea competitivo económicamente, es necesario desarrollar procesos de fermentación que incrementen la baja productividad volumétrica lograda en cultivos convencionales (por lote o continuo, por medio de técnicas que permitan altas concentraciones celulares y reduzcan la inhibición por producto. Uno de los métodos empleados frecuentemente involucra la recirculación celular; por ello, en este trabajo se desarrolló un reactor de membrana incorporando un módulo de filtración, con unidades tubulares de 5 u,m en acero inoxidable, dentro de un fermentador de tanque agitado de 3L, para investigar su aplicación en la producción continua de etanol. Los efectos de la concentración celular y la caída de presión transmembranal sobre el flux de permeado fueron evaluados para probar el desempeño del módulo de filtración. Previa selección de las condiciones de fermentación (30 °C, 1,25 -1,75 vvm, pH 4,5, el sistema con retención celular interna fue operado en el cultivo continuo de Saccharomyces cerevisiae a partir de sacarosa. La permeabilidad de las unidades filtrantes fue mantenida mediante la aplicación de pulsos de aire. Más del 97% de las células cultivadas fueron retenidas en el fermentador, alcanzándose una concentración celular de 51 g/L y una productividad promedio de etanol, en el cultivo con retención celular, de 8,51 g/L.h, la cual fue dos veces mayor a la que se obtiene en un cultivo continuo convencional. Palabras clave: reactor de membrana, Saccharomyces cerevisiae, fermentación alcohólica, recirculación celular.Ethanol has provoked great interest due to its potential as an alternative fuel. Nevertheless, fermentation processes must be developed by increasing the low volumetric productivity achieved in conventional cultures (batch or continuous to make this product become economically competitive

  15. Papel de la monitorización electroencefalográfica continua en el diagnóstico de la epilepsia pediátrica Role of continuous EEG monitoring in the diagnosis of pediatric epilepsy

    Directory of Open Access Journals (Sweden)

    Agustín Legido

    2009-01-01

    Full Text Available El diagnóstico de la epilepsia es fundamentalmente clínico, pero frecuentemente se plantea el diagnóstico diferencial con fenómenos no epilépticos. El desarrollo de la monitorización EEG continua (MEEGC en las últimas dos décadas ha permitido mejorar el diagnóstico de pacientes epilépticos de todas las edades. En este trabajo se revisan los datos de la literatura sobre la eficacia de los distintos tipos de MEEGC en el diagnóstico de la epilepsia pediátrica, resaltando especialmente nuestra experiencia personal. En nuestros estudios, la MEEGC ambulatoria suplementada con video permitió contestar la pregunta que determinó su petición en el 80% de pacientes diagnosticados de epilepsia y en el 83% de aquéllos con sospecha diagnóstica de epilepsia. Con la MEEGC ambulatoria asistida por ordenador, dichas cifras fueron 88% y 89%, respectivamente y con la MEEGC intrahospitalaria con video fueron 82% y 51%, respectivamente. La MEEGC intrahospitalaria con video es crucial en la evaluación de pacientes con epilepsia, candidatos al tratamiento quirúrgico. La MEEGC es también importante en pacientes con encefalopatías agudas ingresados en las unidades de cuidados intensivos. La MEEGC, tanto ambulatoria como intrahospitalaria, es muy útil en el diagnóstico diferencial de fenómenos clínicos epilépticos y no epilépticos y en la confirmación del tipo de epilepsia o síndrome epiléptico. Los avances tecnológicos y el desarrollo de nuevas modalidades de EEG en el futuro, harán que la electroencefalografía siga siendo una técnica muy importante en el estudio de la función cerebral en pacientes con enfermedades neurológicas agudas o crónicas.The diagnosis of epilepsy is basically clinical, but it frequently raises the differential diagnosis with non-epileptic events. The development of continuous EEG monitoring (CEEGM in the past decades has allowed a better diagnosis of epileptic patients of all ages. In this paper we review the

  16. La transformación de un vehículo eléctrico, con la regulación con VTC (variador de tensión continua, en un vehículo con inversor de frecuencia y motor eléctrico asíncrono

    Directory of Open Access Journals (Sweden)

    Ioan Bele

    2003-01-01

    Full Text Available El trabajo presenta la metodología y las condiciones que deben cumplirse para transformar los vehículos de corriente continua, con regulación de la velocidad de marcha por VTC (chopper, en vehículos accionados por corriente alterna con la regulación mediante inversor y motor eléctrico de tracción asíncrono. Tanto en el primer sistema como en el segundo la regulación de la velocidad se hace mediante el autómata programable. En el primer sistema la regulación de la velocidad es posible mediante el control por impulsos del chopper, mientras que en el segundo la regulación se realiza con la modificación tanto de la tensión como de su frecuencia. Las siguientes funciones del autómata programable no se cambian: el control y el seguimiento de las instalaciones auxiliares del interruptor principal, el control y seguimiento de los contactores de línea y también el diseño de los indicadores de la velocidad, la corriente y la tensión. Otras características del autómata programable se cambian totalmente: el control de los tiristores o los transistores, las informaciones con respecto a la corriente, se elimina una serie de componentes y aparatos y además se pueden montar otros aparatos directamente en el inversor. En conclusión, el paso del sistema de accionamiento con máquina eléctrica de corriente continua, y la regulación de la velocidad de marcha con variador de tensión continua VTC (chopper, al sistema de accionamiento con máquina de corriente alterna y la regulación mediante el inversor, puede realizarse de una manera relativamente fácil después de un análisis de las funciones de las instalaciones de control y regulación.

  17. La parábola como lugar geométrico : una formación continua de profesores de matemáticas basada en la Teoría de Registros de Representación Semiótica

    OpenAIRE

    Lara Torres, Isabel Mercedes

    2016-01-01

    La presente investigación aborda la parábola como lugar geométrico en una formación continua de profesores de matemáticas por medio de una secuencia de actividades con el uso del Geogebra y que toma la Teoría de Registros de Representación Semiótica como base teórica. Por ello, nos planteamos la siguiente pregunta de investigación: ¿Cómo profesores de matemática movilizan la noción de parábola como lugar geométrico cuando coordinan diferentes registros de representación semióti...

  18. Estudio del índice y factores que contribuyen a la deserción de los participantes en los cursos virtuales ofrecidos por el departamento de educación continua de la Sociedad Colombiana de Anestesiología y Reanimación (S.C.A.R.E.) durante el año 2011 y presentación de un modelo basado en la andragogía para el control de los mismos

    OpenAIRE

    García Torres, Cecilia

    2012-01-01

    Uno de los principales problemas que enfrenta la educación, en cualquiera de sus niveles, pero en particular en el nivel de educación superior ya sea en modalidad presencial y virtual es la deserción. Este trabajo presenta el análisis cuantitativo de los factores que contribuyen a la presentación de este problema, en lo que respecta a educación continua en modalidad virtual dirigida a profesionales del área de la salud , lo cual se determinó mediante la aplicación de una encuesta electr...

  19. CONJUNTO DE SIGNIFICADOS DEL CUESTIONARIO DE OPINIONES SOBRE CIENCIA, TECNOLOGIA Y SOCIEDAD (COCTS EN LA FORMACIÓN CONTINUA DE DOCENTES DE EDUCACIÓN INICIAL Y EDUCACIÓN BÁSICA PRIMARIA MEDIANTE LA CLASIFICACIÓN MÚLTIPLE DE ÍTEMS

    Directory of Open Access Journals (Sweden)

    Fredy Valencia Valbuena

    2015-12-01

    Full Text Available A continuación se presentan los resultados parciales del Cuestionario Múltiple de Items (CMI, primer instrumento aplicado a un grupo de cuatro profesoras de Educación Inicial y Básica Primaria, como parte del proyecto de tesis doctoral. El instrumento se centró como medio para hacer comparaciones de las concepciones sobre ciencia-tecnología-sociedad-ambiente en el grupo de las profesoras participantes de una convocatoria de cualificación y formación continua en el marco interinstitucional de cooperación 129 de 2014 entre el  Instituto para la Investigación Educativa y el Desarrollo Pedagógico (IDEP y el grupo de investigación: Construcción de Conocimiento Científico desde la Perspectiva de los Enfoques Didácticos, perteneciente al Doctorado Interinstitucional  de la Universidad Pedagógica Nacional (UPN. El análisis de la información se realizó a través del software HUDAP8, cuyos resultados evidencias las tendencias de las profesoras hacia cinco regiones que se identifican con alguna(s de las cuatro categorías taxonómicas: Definiciones de ciencia y tecnología; sociología externa de la ciencia; sociología interna de la ciencia; y epistemología (Vásquez, 2014.

  20. La capacitación continua de los docentes de educación básica en Sonora, México, y la política pública de evaluación: el caso del curso básico nacional al inicio del ciclo escolar

    Directory of Open Access Journals (Sweden)

    Martha Olivia Peña Ramos

    2012-01-01

    Full Text Available En este trabajo se retoma la importancia de la política pública de evaluación en la educación, en el marco de la capacitación continua que reciben los maestros que inician una nueva reforma educativa. Para ello se valora el curso de la Secretaría de Educación Pública denominado “Prioridades y retos de la educación básica”, de donde se evaluó el impacto de la capacitación ofrecida a los docentes en servicio en educación básica. Se evaluaron a 801 docentes de educación básica que llevaron el curso, así como a 178 que no lo tomaron, mismos que fueron seleccionados a partir de un muestreo aleatorio estratificado; queda dividida la población objeto de estudio en cinco regiones: Nogales, Sierra, Hermosillo, Cajeme y Huatabampo del estado de Sonora, México. Se concluye que la capacitación evaluada sí impacta positivamente en los docentes que llevaron el curso, pero aun así no refleja un puntaje esperado sobre conocimientos en competencias impartido en el curso, lo que indica una falta de eficiencia en el sistema de capacitación.

  1. Educação continuada em enfermagem psiquiátrica: reflexão sobre conceitos Educación continua en enfermería psiquiátrica: reflexión sobre conceptos Continuing education in psychiatric nursing: a reflection on concepts

    Directory of Open Access Journals (Sweden)

    Maria da Graça Girade

    2006-03-01

    Full Text Available A preocupação com programas para capacitar o enfermeiro, para atuar em enfermagem psiquiátrica, levou-nos a este estudo, o primeiro da linha de pesquisa "Desenvolvimento do pessoal de enfermagem na área da psiquiatria e saúde mental". O objetivo deste foi fazer uma reflexão sobre os conceitos de educação continuada, em serviço e permanente existentes na literatura mais recente sobre o assunto. Para o levantamento bibliográfico dos conceitos em pauta, utilizamos as bases de dados MEDLINE e LILACS, dissertações e teses da área da enfermagem e alguns títulos clássicos sobre o assunto. Após análise dos conceitos e discussão com peritos, concluímos que a denominação educação contínua em serviço é a que guarda mais consonância com os autores e peritos consultados e a que mais atende às demandas de conhecimento existentes na área de assistência de enfermagem psiquiátrica rumo à qualidade da assistência.La preocupación con programas para capacitar al enfermero, para actuar en enfermería psiquiátrica, nos llevó realizar este estudio, el primero de la línea de investigación "Desarrollo del personal de enfermería en el área de la psiquiatría y salud mental". El objetivo de este estudio fue hacer una reflexión sobre los conceptos de educación continua, en servicio y permanente existentes en la literatura más reciente sobre el asunto. Para el levantamiento bibliográfico de los conceptos mencionados, utilizamos las bases de datos MEDLINE y LILACS, disertaciones y tesis del área de la enfermería y algunos títulos clásicos sobre el asunto. Después del análisis de los conceptos y discusión con expertos, concluimos que la denominación educación continua en servicio es la que guarda más consonancia con los autores y expertos consultados y la que más atiende a las demandas del conocimiento existentes en el área de la asistencia de enfermería psiquiátrica rumbo a la calidad de la asistencia.The concern with

  2. Analysis of the consumption of useful life by thermal fatigue in the gas turbine nozzles during the operation at continuous load and transients; Analisis de consumo de vida por fatiga termica en las toberas de turbina de gas durante operacion con carga continua y transitorios

    Energy Technology Data Exchange (ETDEWEB)

    Perez Hernandez, Efrain Betuel

    2007-08-15

    The gas turbines operate at extremely high temperatures, with high thermal and mechanical stresses, causing that the life of the involved components diminishes. In the present thesis the temperature distribution on the nozzle obtained in other investigation as a result of heat transfer and fluid flow analysis applying CDF code Star-CD was used. Next, the program NISA was used to perform the analysis of thermal stresses by means of finite element method. Finally, the results of stress analysis were introduced to the program nCode to accomplish the nozzle remaining useful life assessment due to thermal fatigue in critical location on the nozzle by means of the CLF module (Critical Location Fatigue). The full methodology used to determine the nozzle operational conditions, load history, material properties and the fatigue model used to determine the number of cycles to failure of the nozzle during constant load and transients operation is presented. [Spanish] Las turbinas de gas operan a temperaturas extremadamente altas, a elevados esfuerzos termicos y mecanicos, ocasionando que la vida de los componentes involucrados se reduzca. En la presente tesis se presentan los resultados realizados por otras investigaciones de temperaturas obtenidas a partir de un analisis de transferencia de calor y flujo de fluidos de la tobera mediante el programa Star-CD basado en volumenes finitos. Posteriormente, se utilizo el programa NISA para realizar el analisis de esfuerzos mediante elementos finitos. Finalmente, se llevaron los resultados al programa nCode para realizar la estimacion de vida util por fatiga termica en un punto critico de la tobera mediante el modulo CLF (Critical Location Fatigue). Se muestra la metodologia empleada para determinar las condiciones de operacion, historial de carga, propiedades del material y el modelo de dano por fatiga para determinar el numero de ciclo para falla de la tobera durante operacion con carga continua y transitorios.

  3. On aspects of vibration of axially moving continua

    NARCIS (Netherlands)

    Hageraats-Ponomareva, S.

    2009-01-01

    In axially moving structures like conveyor belt systems, magnetic tapes, and so on, vibrations occur due to the presence of different kinds of imperfections in the systems. For these structures internal resonances can lead to severe vibrations. Resonance free conveyor belt systems can be constructed

  4. Graph-like continua, augmenting arcs, and Menger's theorem

    DEFF Research Database (Denmark)

    Thomassen, Carsten; Vella, Antoine

    2008-01-01

    We show that an adaptation of the augmenting path method for graphs proves Menger's Theorem for wide classes of topological spaces. For example, it holds for locally compact, locally connected, metric spaces, as already known. The method lends itself particularly well to another class of spaces......, connected graph. While closed subsets of such a space behave nicely in that they are compact and locally connected (and therefore locally arcwise connected), the general subspaces do not: They may be connected without being arcwise connected. Nevertheless, they satisfy Menger's Theorem......., namely the locally arcwise connected, hereditarily locally connected, metric spaces. Finally, it applies to every space where every point can be separated from every closed set not containing it by a finite set, in particular to every subspace of the Freudenthal compactification of a locally finite...

  5. The Intrinsic Far-infrared Continua of Type-1 Quasars

    Energy Technology Data Exchange (ETDEWEB)

    Lyu, Jianwei; Rieke, George H., E-mail: jianwei@email.arizona.edu [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States)

    2017-06-01

    The range of currently proposed active galactic nucleus (AGN) far-infrared templates results in uncertainties in retrieving host galaxy information from infrared observations and also undermines constraints on the outer part of the AGN torus. We discuss how to test and reconcile these templates. Physically, the fraction of the intrinsic AGN IR-processed luminosity compared with that from the central engine should be consistent with the dust-covering factor. In addition, besides reproducing the composite spectral energy distributions (SEDs) of quasars, a correct AGN IR template combined with an accurate library of star-forming galaxy templates should be able to reproduce the IR properties of the host galaxies, such as the luminosity-dependent SED shapes and aromatic feature strengths. We develop tests based on these expected behaviors and find that the shape of the AGN intrinsic far-IR emission drops off rapidly starting at ∼20 μ m and can be matched by an Elvis et al.-like template with a minor modification. Despite the variations in the near- to mid-IR bands, AGNs in quasars and Seyfert galaxies have remarkably similar intrinsic far-IR SEDs at λ ∼ 20–100 μ m, suggesting a similar emission character of the outermost region of the circumnuclear torus. The variations of the intrinsic AGN IR SEDs among the type-1 quasar population can be explained by the changing relative strengths of four major dust components with similar characteristic temperatures, and there is evidence for compact AGN-heated dusty structures at sub-kiloparsec scales in the far-IR.

  6. Integración continua para open hardware

    OpenAIRE

    Peral Chico, David del

    2012-01-01

    En estos últimos años, la informática, y más concretamente, el hardware, está evolucionando hacia sistemas empotrados. La aparición de nuevos mercados como los micrordenadores, televisiones inteligentes, etc., y masificación de los existentes como los teléfonos inteligentes y las tablets amplifica este fenómeno. Esto es debido a las ventajas de dichos sistemas en cuanto a coste a escala, optimización y rendimiento, consumo de energía o tamaño, entre otras. Los sistemas empotrados crecen en so...

  7. Esclerodermia associada a atividade elétrica muscular continua

    Directory of Open Access Journals (Sweden)

    José Antonio Levy

    1965-12-01

    Full Text Available É relatado o caso de um paciente do sexo masculino, de 15 anos de idade, que apresentava dificuldade para movimentar os braços e para abrir a bôca, além de dispnéia, evoluindo lentamente há dois anos. O exame neurológico revelou hipertonia em todo o corpo, predominando em alguns grupos musculares que se achavam fortemente contraturados, obrigando o paciente a assumir atitudes anormais, impossibilitando-o, ainda, de abrir a bôca e de respirar livremente, dada a grande diminuição da expansibilidade torácica. O exame eletromiográfico revelou a presença de atividade muscular contínua, mesmo durante o repouso, caracterizada por descargas de alta freqüência, as quais persistiram após bloqueio anestésico de nervo periférico e após anestesia geral, sõmente sendo eliminados pelo curare. Com o diagnóstico de esclerodermia e de miosite, embora só a primeira dessas moléstias pudesse ser comprovada anátomo-patològicamente, o paciente foi tratado com corti-costeróides, tendo havido discreta melhora do quadro clínico, sobretudo em relação aos movimentos respiratórios e à abertura da bôca. Tendo, então, o conhecimento de dois casos semelhantes estudados por Isaacs em 1961, com o nome de síndrome da atividade contínua da fibra muscular, os quais haviam sido curados com o uso de hidantoinato de sódio, os autores empregaram esta mesma medicação, tendo verificado, após alguns dias, a diminuição acentuada da atividade anormal pelo exame eletromiográfico.

  8. Liderazgo transformador y formación continua

    Directory of Open Access Journals (Sweden)

    Alicia E. Kaufmann

    1997-01-01

    Full Text Available en este articulo se consideran algunas de las creencias mas habituales respecto al liderazgo, para luego centrarnos en definir lo que se entiende por lider transformador. este ultimo no ocupa un lugar jerarquico dentro de la organizacion, sino que forma parte de un proceso de aprendizaje e intercambio con sus seguidores. se consideran estudios de usa y españa sobre el tema, que coinciden que "honestidad" y "eficacia" son los rasgos mas valorados en ambas sociedades. en los barometros del cis, la honestidad aparece como el atributo mas valorado por la poblacion española a lo largo de estos ultimos diez años. si bien las mujeres, por su flexibilidad innata, ostentan rasgos potenciales de lider para la turbulenta sociedad actual, su acceso real a traves de la formacion se vislumbra aun distante, en terminos reales.

  9. Revestimientos asfálticos sobre bases continuas

    Directory of Open Access Journals (Sweden)

    Eberle, Karl

    1963-10-01

    Full Text Available In the course of a meeting connected with research on road pavements, held at Konstance, in Germany, Dr. Eberle submitted for discussion and study two new methods for the construction of modern pavements. In general outline, the first of these methods consists in placing a layer of gravel, of about 18 cms depth, on top of the foundation base, after suitably treating the latter to protect it against frost. An asphaltic layer of much smaller depth is then placed on the gravel layer, which constitutes a flexible base. The asphaltic layer is the actual traffic pavement. The second method is similar to the first as regards the grading, box and foundation. The only difference is that cement mortar is applied to the gravel base, into the hollow spaces of which the mortar is made to penetrate. In both methods the top pavement is consolidated mechanically by means of suitable auxiliary equipment. The choice of one or other of the previous two methods depends on the results obtained from a general study of the location and quality of the available crushed stone, and on the facility to transport these materials to the prepared graded subbases. The author claims that the rational use of these methods gives good results, both technically and economically.Con motivo de celebrarse una reunión encargada de la investigación I sobre firmes para carreteras, verificada en Konstanz, Alemania, el autor expuso para su estudio y consideración dos nuevos métodos constructivos para afirmados modernos. El primero de estos métodos consiste, a grandes rasgos, en colocar una capa, de grava, de unos 18 cm de espesor, sobre la superficie de la base de cimiento, convenientemente tratada, para protegerla contra las heladas. Sobre esta capa, que constituye un firme flexible, se coloca otra asfáltica de mucho menor espesor, que sirve de rodadura. El segundo método es similar al anterior en lo que se refiere a la explanación, caja y cimiento; la única diferencia estriba en que para este último se emplea mortero de cemento, al cual se le hace penetrar en los huecos de la grava colocada previamente. En ambos métodos, la capa que constituye el firme se ha consolidado mecánicamente utilizando maquinaria auxiliar. La elección o preferencia de un método sobre otro es una consecuencia del estudio general en el que se tiene en cuenta, la situación y calidad de las canteras o piedra machacada disponible, transporte y acceso de materiales a las excavaciones o plataformas preparadas. El autor pretende que el empleo racional de estos métodos da buenos resultados, tanto de carácter técnico como económicos.

  10. Green's Function and Stress Fields in Stochastic Heterogeneous Continua

    Science.gov (United States)

    Negi, Vineet

    Many engineering materials used today are heterogenous in composition e.g. Composites - Polymer Matrix Composites, Metal Matrix Composites. Even, conventional engineering materials - metals, plastics, alloys etc. - may develop heterogeneities, like inclusions and residual stresses, during the manufacturing process. Moreover, these materials may also have intrinsic heterogeneities at a nanoscale in the form of grain boundaries in metals, crystallinity in amorphous polymers etc. While, the homogenized constitutive models for these materials may be satisfactory at a macroscale, recent studies of phenomena like fatigue failure, void nucleation, size-dependent brittle-ductile transition in polymeric nanofibers reveal a major play of micro/nanoscale physics in these phenomena. At this scale, heterogeneities in a material may no longer be ignored. Thus, this demands a study into the effects of various material heterogeneities. In this work, spatial heterogeneities in two material properties - elastic modulus and yield stress - have been investigated separately. The heterogeneity in the elastic modulus is studied in the context of Green's function. The Stochastic Finite Element method is adopted to get the mean statistics of the Green's function defined on a stochastic heterogeneous 2D infinite space. A study of the elastic-plastic transition in a domain having stochastic heterogenous yield stress was done using Mont-Carlo methods. The statistics for various stress and strain fields during the transition were obtained. Further, the effects of size of the domain and the strain-hardening rate on the stress fields during the heterogeneous elastic-plastic transition were investigated. Finally, a case is made for the role of the heterogenous elastic-plastic transition in damage nucleation and growth.

  11. Deformation in Metallic Glass: Connecting Atoms to Continua

    Science.gov (United States)

    Hinkle, Adam R.; Falk, Michael L.; Rycroft, Chris H.; Shields, Michael D.

    Metallic glasses like other amorphous solids experience strain localization as the primary mode of failure. However, the development of continuum constitutive laws which provide a quantitative description of disorder and mechanical deformation remains an open challenge. Recent progress has shown the necessity of accurately capturing fluctuations in material structure, in particular the statistical changes in potential energy of the atomic constituents during the non-equilibrium process of applied shear. Here we directly cross-compare molecular dynamics shear simulations of a ZrCu glass with continuum shear transformation zone (STZ) theory representations. We present preliminary results for a methodology to coarse-grain detailed molecular dynamics data with the goal of initializing a continuum representation in the STZ theory. NSF Grants Awards 1107838, 1408685, and 0801471.

  12. Far-IR and Radio Thermal Continua in Solar Flares

    Czech Academy of Sciences Publication Activity Database

    Kašparová, Jana; Heinzel, Petr; Karlický, Marian; Moravec, Z.; Varady, M.

    2009-01-01

    Roč. 33, - (2009), s. 309-315 ISSN 1845-8319 R&D Projects: GA ČR GA205/04/0358; GA ČR GP205/06/P135; GA ČR GA205/07/1100 Institutional research plan: CEZ:AV0Z10030501 Keywords : solar flares * radiative hydrodynamics * continuum emission Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  13. The near-infrared continua of BL Lacertae objects

    International Nuclear Information System (INIS)

    Allen, D.A.; Ward, M.J.; Hyland, A.R.

    1982-01-01

    Accurate photometry at J, H and K (1.2 to 2.2 μm) has been secured of 53 BL Lac objects. A power-law continuum is an exceptionally good fit to the data, and the colours are distinct from those of quasars. There is no indication of the additional infrared continuum seen in quasars and which is believed to arise in circumnuclear dust. We argue that dust is very scarce in the nuclei of BL Lac objects, and thus we expect gas to be equally scarce. Hence we attribute the lack of optical emission lines to an absence of ionized nuclear gas. We further argue that BL Lac objects could underlie quasars, the latter exhibiting line and thermal continuum emission at ultraviolet, optical and near-infrared wavelengths due to the presence of circumnuclear gas and dust. The strong-lined optically violent variable quasars have colours typical of BL Lac objects rather than quasars, and may represent intermediate cases. The JHK colours of the BL Lac objects overlap with those of the empty-radio-field infrared sources. Such objects probably represent the redder extreme of a range of spectral indices in BL Lac objects. (author)

  14. A Treatise on Micromorphic Continua : Theory, Homogenization, Computation

    NARCIS (Netherlands)

    Hirschberger, C.B.

    2008-01-01

    The main goal of this work is to model size effects, as they occur in materials with an intrinsic microstructure at the consideration of specimens that are not by orders larger than this microstructure. The micromorphic continuum theory as a generalized continuum theory is well suited to account for

  15. Desarrollo de Simuladores para Procesos Industriales. Parte III (Colada continua

    Directory of Open Access Journals (Sweden)

    Ramírez, A.

    2006-06-01

    Full Text Available This work was written for illustrating the use of Monte Carlo methods and generating of random number in combination with the information of the simulation system for thermal behavior described previously in order to reproduce in a computer the solidification process of the steel and simulate the formation of structures of casting step by step.

    Este trabajo muestra el empleo de técnicas de métodos de Monte Carlo y generación de números aleatorios en combinación con datos obtenidos del sistema de simulación (SSCC para comportamiento térmico previamente descrito para la reproducción computacional del proceso de solidificación del acero y simular la formación de estructuras de colada paso a paso.

  16. A mathematical formulation for large strain analysis of geologic continua

    International Nuclear Information System (INIS)

    Chaudhary, A.B.; Vakili, J.E.; Hume, H.R.

    1987-12-01

    A solution method is presented for finite-deformation analysis of geologic materials. The principle of virtual work is used to state the equations of equilibrium in a weak form. These equations are linearized about the last-established equilibrium configuration. A material constitutive relationship between the Green-Naghdi stress rate and the rate-of-deformation tensor is used to obtain the current stresses. The finite-element governing equations are expressed in a form suitable for an iterative solution strategy. The obtained gradient matrix contains the effects of both material and geometric nonlinearities. The primary application area of this formulation is the analysis of long-term deformation response of the region adjoining the mining shafts and the waste emplacement rooms within a nuclear waste repository. In this region, the strains are expected to be large, and the infinitesimal strain analysis would introduce inaccuracies in the solution. 19 refs., 6 figs

  17. Comparación de los métodos de Bray & Kurtz N° i y Mehlich III en la determinación de la disponibilidad de fósforo en suelos con fertilizaciones continuas Comparison of Bray & Kurtz N°1 and Mehlich III methods in the determination of phosphorus availability in soils with continuous fertilizations

    Directory of Open Access Journals (Sweden)

    González Mirta

    2007-07-01

    Full Text Available Este trabajo propone comparar dos métodos de evaluación de fósforo extractable, Bray & Kurtz I, de uso habitual en la zona pampeana y Mehlich III, de uso internacional en suelos que han recibido fertilizaciones fosfatadas continuas. Los suelos estudiados recibieron dosis crecientes de fertilizante fosfatado, aplicadas al inicio de una rotación de maíz, trigo y soja. Sobre parcelas de campo, se tomaron muestras de suelo, se analizaron y se compararon los datos de fósforo extractable (P por Mehlich III y Bray & Kurtz I. Para determinar la bondad de ambos métodos, se ajustaron los datos con la prueba de Peto-Wilcoxon de determinación de curvas de concordancia y análisis de regresión para evaluar la sensibilidad de ambos métodos. Los resultados mostraron que a valores bajos, ambos métodos no se diferencian sustancialmente, pero a partir de los 15 (mg kg-1 de P en el suelo, el método de Mehlich III sobreestima el valor con respecto a Bray & Kurtz I.También fue Bray & Kurtz I el que detectó la mejor variación de las dosis agregadas de P, mostrando mayor sensibilidad entre los tratamientos efectuados. Se concluye que de los estudios realizados el método de Bray & Kurtz I es el que mejor se adapta a las prácticas de diagnóstico y recomendaciones regionales de uso de fertilizante.In this work, we compared two methods of available phosphorus evaluation, Bray & Kurtz I, (the most common in the pampean zone, and Mehlich III, (commonly used in other countries in soils with contionuous P applications. The studied soils received increasing doses of phosphate fertilizer, applied to the beginning of a maize, wheat and soybean rotation. Soil samples were taken in the field, and extractable phosphorus (P by Mehlich III and Bray & Kurtz I methods were compared. The data were adjusted with the Peto-Wilcoxon test of determination and regression analysis to evaluate the sensitivity of both methods. The results indicated that to low values, these are

  18. Evaluación de un programa de educación médica continua para la atención primaria en la prescripción de hipoglucémicos An evaluation of a continuing medical education program for primary care services in the hypoglycemic agent’s prescription in diabetes mellitus type 2

    Directory of Open Access Journals (Sweden)

    Angélica Castro-Ríos

    2008-01-01

    Full Text Available OBJETIVO: Evaluar el efecto en la prescripción de hipoglucémicos de un programa de educación médica continua en unidades de medicina familiar (UMF. MATERIAL Y MÉTODOS: Se realizó un estudio observacional que comparó dos grupos (con y sin programa con dos cortes transversales (antes y después. La unidad de análisis fue la consulta. El periodo de análisis comprendió seis meses anteriores y seis posteriores a la institución del programa. La principal variable de resultado fue la prescripción adecuada, evaluada mediante dos criterios: elección e indicación correctas. El análisis incluyó modelos de regresión logística, se aplicó la técnica de dobles diferencias y se ajustó por variables relativas al paciente, la consulta y la UMF; las más relevantes fueron sexo, obesidad, otras afecciones, número de consultas, número de medicamentos, tamaño de la clínica, grupo y etapa. RESULTADOS: Se obtuvo un incremento atribuible al programa de 0.6% en la probabilidad de prescripción adecuada y de 11% en la elección correcta en pacientes obesos.OBJECTIVE: To evaluate the impact of a continuing medical education program on family doctors to improve prescription of hypoglycemic drugs. MATERIAL AND METHODS: An observational study was conducted with two groups of comparison (with-without program and before-after periods. The unit of analysis was the visit. The period of evaluation comprised six months before and six after implementing the program. The outcome variable was the appropriateness of prescription that was based upon two criteria: appropriate selection and proper indication of the drug. Logistic regression models and the double differences technique were used to analyze the information. Models were adjusted by independent variables related with the patient, the visit and the PCC, the more relevant ones were: sex, obesity, conditions other than diabetes, number of visits in the analyzed period, number of drugs prescribed, size of

  19. Efeito do ultra-som terapêutico contínuo em placas epifisárias de coelhos Efectos de la ultrasonografia terapéutica continua en placas epifisarias de conejos Effect of continuous therapeutic ultrasound in rabbit growth plates

    Directory of Open Access Journals (Sweden)

    Andersom Ricardo Fréz

    2006-06-01

    Full Text Available Devido aos efeitos terapêuticos, o ultra-som tem se tornado ferramenta indispensável no tratamento fisioterapêutico de alterações causadas por lesões e em diversas doenças, porém seu uso em pacientes pediátricos é controverso por possíveis distúrbios e danos à placa epifisária. O objetivo deste estudo é verificar se o ultra-som contínuo apresenta efeitos de alteração na placa de crescimento da tíbia de coelhas. Oito coelhas da raça Nova Zelândia com dois meses de idade foram submetidas a um tratamento usando ultra-som terapêutico de forma contínua com dose de 1W/cm² na região lateral da articulação do joelho direito por 5min, durante 10 dias com dois dias de intervalo após a 5ª aplicação. A articulação do joelho esquerdo foi utilizada como controle. A análise histológica mostrou uma alteração na espessura da cartilagem epifisária, sendo que no lado tratado o tamanho foi 24,40% maior do que no controle (p Debido a los efectos terapéuticos, la ultrasonografía se ha convertido en una herramienta indispensable al tratamiento fisioterapéutico de las alteraciones causadas por lesiones y en diversas enfermedades, a pesar de esto su uso en pacientes pediátricos es controversial por los posibles disturbios y daños a la placa epifisaria. El objetivo de este estudio es verificar si la ultrasonografía continua presenta efectos de alteración en la placa de crecimiento de al tibia de conejas. Ocho conejas de la raza Nueva Zelanda con 2 meses de edad fueron sometidas a un tratamiento usando ultrasonografía terapéutica de forma continua con dosis de 1W/cm² en la región lateral de la articulación de la rodilla derecha por 5 min, durante 10 días con 2 días de intervalo después de la 5ª aplicación. La articulación de la rodilla izquierda fue utilizada como control. El análisis histológico reportó una alteración en la espesura del cartílago epifisario, en el lado tratado el tamaño fue de 24,40% mayor del

  20. What is the fate of disconnected brain tissue in a child with Rasmussen syndrome? A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S.J.; Park, Y.D. [Dept. of Neurology (Child), Medical Coll. of Georgia, Augusta, GA (United States); Pillai, J. [Dept. of Radiology, Medical Coll. of Georgia, Augusta, GA (United States)

    2003-04-01

    We describe a case of Rasmussen syndrome in a 7-year-old boy, presenting with epilepsia partialis continua, hemiplegia, and progressive mental deterioration. The initial MRI examination was normal, followed by progressive left hemispheric cortical atrophy and abnormal high signal intensity over the left occipital, parietal, and cingulate gyral areas over an 18-month period. On the basis of the clinical diagnosis and biopsy findings of Rasmussen syndrome, functional hemispherectomy was carried out at 7.5 years of age with alleviation of clinical seizures for the following 44 months. The follow-up MRI demonstrated atrophic changes involving the remaining left hemisphere with increased signal and cortical volume loss, as well as the absence of abnormal signal in the right hemisphere at 10 years of age. Our MRI findings are consistent with the progression of Rasmussen syndrome in the ipsilateral hemisphere even after functional-hemispherectomy without clinical seizures. (orig.)

  1. What is the fate of disconnected brain tissue in a child with Rasmussen syndrome? A case report

    International Nuclear Information System (INIS)

    Kim, S.J.; Park, Y.D.; Pillai, J.

    2003-01-01

    We describe a case of Rasmussen syndrome in a 7-year-old boy, presenting with epilepsia partialis continua, hemiplegia, and progressive mental deterioration. The initial MRI examination was normal, followed by progressive left hemispheric cortical atrophy and abnormal high signal intensity over the left occipital, parietal, and cingulate gyral areas over an 18-month period. On the basis of the clinical diagnosis and biopsy findings of Rasmussen syndrome, functional hemispherectomy was carried out at 7.5 years of age with alleviation of clinical seizures for the following 44 months. The follow-up MRI demonstrated atrophic changes involving the remaining left hemisphere with increased signal and cortical volume loss, as well as the absence of abnormal signal in the right hemisphere at 10 years of age. Our MRI findings are consistent with the progression of Rasmussen syndrome in the ipsilateral hemisphere even after functional-hemispherectomy without clinical seizures. (orig.)

  2. Local cerebral metabolism during partial seizures

    International Nuclear Information System (INIS)

    Engel, J. Jr.; Kuhl, D.E.; Phelps, M.E.; Rausch, R.; Nuwer, M.

    1983-01-01

    Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for each patient studied. Focal and generalized increased and decreased metabolism were observed. Ictal hypermetabolism may exceed six times the interictal rate and could represent activation of excitatory or inhibitory synapses in the epileptogenic region and its projection fields. Hypometabolism seen on ictal scans most likely reflects postictal depression and may indicate projection fields of inhibited neurons. No quantitative relationship between alterations in metabolism and EEG or behavioral measurements of ictal events could be demonstrated

  3. Local cerebral metabolism during partial seizures

    Energy Technology Data Exchange (ETDEWEB)

    Engel, J. Jr.; Kuhl, D.E.; Phelps, M.E.; Rausch, R.; Nuwer, M.

    1983-04-01

    Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for each patient studied. Focal and generalized increased and decreased metabolism were observed. Ictal hypermetabolism may exceed six times the interictal rate and could represent activation of excitatory or inhibitory synapses in the epileptogenic region and its projection fields. Hypometabolism seen on ictal scans most likely reflects postictal depression and may indicate projection fields of inhibited neurons. No quantitative relationship between alterations in metabolism and EEG or behavioral measurements of ictal events could be demonstrated.

  4. Opercular myoclonic-anarthric status epilepticus: A report of two cases

    Directory of Open Access Journals (Sweden)

    Janapareddy Vijaya Bhaskara Rao

    2013-01-01

    Full Text Available Opercular myoclonic-anarthric status epilepticus (OMASE is an uncommon disorder of diverse etiology. This condition is characterized by fluctuating cortical dysarthria associated with epileptic myoclonus involving glossopharyngeal musculature bilaterally. We report two cases of OMASE of vascular etiology in adults. In both patients, ictally clonic expression was consistent with epilepsia partialis continua and bilateral, symmetrical involvement of soft palate in one patient and tongue, lips, chin and inferior jaw in both patients due to bilateral projections of the inferior corticonuclear pathways. The inferior rolandic area of dominant and high frontal region in non-dominant hemispheres were involved by an epileptogenic lesion of vascular etiology, which was confirmed by magnetic resonance imaging of brain and single photon emission computerized tomography. Carotid Doppler study showed thrombosis of internal carotid artery in both patients, suggestive of an embolic origin. Early recognition of OMASE is important for early management of carotid occlusive disease.

  5. Twelve recommendations for integrating existing systematic reviews into new reviews: EPC guidance.

    Science.gov (United States)

    Robinson, Karen A; Chou, Roger; Berkman, Nancy D; Newberry, Sydne J; Fu, Rongwei; Hartling, Lisa; Dryden, Donna; Butler, Mary; Foisy, Michelle; Anderson, Johanna; Motu'apuaka, Makalapua; Relevo, Rose; Guise, Jeanne-Marie; Chang, Stephanie

    2016-02-01

    As time and cost constraints in the conduct of systematic reviews increase, the need to consider the use of existing systematic reviews also increases. We developed guidance on the integration of systematic reviews into new reviews. A workgroup of methodologists from Evidence-based Practice Centers developed consensus-based recommendations. Discussions were informed by a literature scan and by interviews with organizations that conduct systematic reviews. Twelve recommendations were developed addressing selecting reviews, assessing risk of bias, qualitative and quantitative synthesis, and summarizing and assessing body of evidence. We provide preliminary guidance for an efficient and unbiased approach to integrating existing systematic reviews with primary studies in a new review. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Quality assurance and supervision of mass concrete construction under EPC mode

    International Nuclear Information System (INIS)

    Peng Hong

    2013-01-01

    Taking one typical general contraction project-Hainan Changjiang nuclear power project as an example, this paper introduces the mass concrete construction of nuclear island foundation of Unit 1 in its installation phase, elaborates how to conduct quality assurance and supervision for concrete production, construction, supervision and management, detects relevant weak points of quality and management in the mass concrete construction through quality assurance supervision, puts forward management requirements for the supervising organizations, accumulates useful experience on how to promote contractors to implement the contract in line with national laws, regulations and to improve the management in equipment installation, commissioning and acceptance. (authors)

  7. NPP Design Basis Handover and Knowledge Preservation from Subcontractors, Vendors and EPC

    International Nuclear Information System (INIS)

    Freeland, Kent

    2013-01-01

    Using PLM-based Workflow for Configuration Management (CM) in the Nuclear Power Industry Advantages – some work to do! • NPP’s must adapt to using PLM-based solutions to support CM and to synchronize design changes to asset or product changes, and reduce “slipstreaming”. In the NPP world, this often appears as events that circumvent CM – for example, non-approved parts substitutions and “temporary” plant modifications that are never removed. • PLM serves as the method for unifying the application of requirements to design changes, processes and workflow. In NPP’s, requirements are generally considered only relevant to designs – not process and workflow. • PLM supports Configuration Management and Design Basis in Regulator Action Tracking for NPP’s, and application of PLM-based CM to regulator action and compliance systems. This is a poorly-understood application of CM in NPP’s, yet these elements control large parts of the NPP design basis. • Suppliers, EPC’s and Technology Vendors must also understand the role of CM, SE and PLM in construction of new standards-driven NPP designs (like EPR and Westinghouse AP-1000 NPP designs), as well as understanding the role and handling of Knowledge Systems

  8. Feasibility of EPC to BPEL Model Transformations based on Ontology and Patterns

    NARCIS (Netherlands)

    Meertens, Lucas O.; Iacob, Maria Eugenia; Eckartz, Silja M.; Rinderle-Ma, Stefanie; Sadiq, Shazia; Leymann, Frank

    2010-01-01

    Model-Driven Engineering holds the promise of transforming business models into code automatically. This requires the concept of model transformation. In this paper, we assess the feasibility of model transformations from Event-driven Process Chain models to Business Process Execution Language

  9. Evaluation of a novel stent technology: the Genous EPC capturing stent

    NARCIS (Netherlands)

    Klomp, M.

    2012-01-01

    Tegenwoordig gebruiken ziekenhuizen een nieuwe stent bij dotterbehandelingen van kransslagadervernauwingen. Deze Genous-stent heeft een laag met antistoffen waardoor het behandelde bloedvat snel bedekt raakt met lichaamseigen cellen. Zo wordt tegengegaan dat er opnieuw een vernauwing optreedt of dat

  10. Radiation and Thermal Cycling Effects on EPC1001 Gallium Nitride Power Transistors

    Science.gov (United States)

    Patterson, Richard L.; Scheick, Leif Z.; Lauenstein, Jean M.; Casey, Megan C.; Hammoud, Ahmad

    2012-01-01

    Electronics designed for use in NASA space missions are required to work efficiently and reliably under harsh environment conditions. These include radiation, extreme temperatures, and thermal cycling, to name a few. Information pertaining to performance of electronic parts and systems under hostile environments is very scarce, especially for new devices. Such data is very critical so that proper design is implemented in order to ensure mission success and to mitigate risks associated with exposure of on-board systems to the operational environment. In this work, newly-developed enhancement-mode field effect transistors (FET) based on gallium nitride (GaN) technology were exposed to various particles of ionizing radiation and to long-term thermal cycling over a wide temperature range. Data obtained on control (un-irradiated) and irradiated samples of these power transistors are presented and the results are discussed.

  11. EPC1/TIP60-mediated histone acetylation facilitates spermiogenesis in mice

    DEFF Research Database (Denmark)

    Dong, Yixin; Isono, Kyo Ichi; Ohbo, Kazuyuki

    2017-01-01

    Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for hyperacetylation- mediated histone replacement remains poorly understood. Here...

  12. Experiences and Comparison Study of EPC & UML For Business Process & IS Modeling

    OpenAIRE

    Md. Rashedul Islam; Md. Rofiqul Islam; Md. Shariful Alam; Md. Shafiul Azam

    2011-01-01

    Business process modeling is an approach by which we can analyze and integrate the business process. Using the Business Process Modeling we can represent the current and future process of a business/organization/enterprise. The business process modeling is a prerequisite and essential implementing a business or making any automation system. In this paper, we present our experience in a Business Process Modeling for organization. This paper presents detailed description about business process ...

  13. Adherencia al tratamiento con presión positiva continua nasal en pacientes con síndrome de apnea/hipoapnea del sueño Compliance with continuous positive airway pressure therapy in patients with sleep apnea/hypopnea syndrome

    Directory of Open Access Journals (Sweden)

    Claudio W. Gallego

    2004-10-01

    Full Text Available Se evalúan prospectivamente los factores predictores y nivel de cumplimiento del tratamiento con presión positiva continua nasal (CPAP en un grupo de pacientes con síndrome de apnea del sueño. Valora efectos adversos y estado del equipamiento: interfase siliconada (IS, máscara-conectores (M-C, tubuladura (TU y arnés (A. Se incluyeron pacientes con >3meses de tratamiento, se registraron las horas de encendido mediante el contador horario al inicio, 2 y 4 meses. Definimos paciente cumplidor (C+ al que usara el CPAP >4h/d y >5d/semana. De los 46 pacientes estudiados (hombres 34; edad 62±9 años; IMC 33±7kg/m²; IAH 38±18/h; inicio 2.1±1.7años; CPAP 9±1.4cmH2O, 34 tenían contador horario y 24 (71% eran C+. El motivo de consulta fue: hipersomnolencia (65%, ronquido (39%, apneas vistas por cónyuge (28%. Entre C+ y C- no hallamos diferencias significativas en edad, IMC, presión de CPAP, tiempo de tratamiento, IAH, y clasificación de Epworth pre-tratamiento. Las horas de uso referidas vs. medidas para C+ y C- fueron 6.6±1 vs. 6.1±1 (p=0.02 y 5.6±1 vs 2.4±1 (p1año de uso, observamos un menor porcentaje de elementos categorizados como óptimos (87 a 44%, 74 a 44%, 83 a 44%, 91 a 78%, respectivamente. Los defectos más frecuentes fueron: endurecimiento de IS, rajaduras en IS, M-C y TU, conexiones flojas. El estudio confirma la importancia del monitoreo objetivo en pacientes con CPAP. Especial atención merece la presencia de efectos adversos y el control del estado del equipo que podrían afectar el tratamiento eficaz.Predictive factors and compliance level were evaluated in a group of patients with sleep apnea syndrome under CPAP treatment, assessing side effects and equipment condition: silicone interface (SI, mask-conectors (M-C, air tube (AT and head strap (HS. Patients with >3mo treatment were included, clock counter reading was registered at the beginning, 2 and 4 mo. Patients were considered compliant (C+ when usage was >4h

  14. Analgesia de parto: estudo comparativo entre anestesia combinada raquiperidural versus anestesia peridural contínua Analgesia de parto: estudio comparativo entre anestesia combinada raqui-peridural versus anestesia peridural continua Labor analgesia: a comparative study between combined spinal-epidural anesthesia versus continuous epidural anesthesia

    Directory of Open Access Journals (Sweden)

    Carlos Alberto de Figueiredo Côrtes

    2007-02-01

    ão necessários para avaliar diferença na incidência de cesarianas.JUSTIFICATIVA Y OBJETIVOS: El alivio del dolor en el trabajo de parto ha recibido una atención constante objetivando el bienestar materno, disminuyendo el estrés causado por el dolor y reduciendo las consecuencias de éste sobre el concepto. Innumerables técnicas pueden ser utilizadas para la analgesia de parto. Este trabajo tuvo como objetivo comparar la técnica peridural continua con la combinada, ambas con el uso de bupivacaína a 0,25% en exceso enantiomérico 50% y fentanil como agentes. MÉTODO: Participaron del estudio 40 parturientes en trabajo de parto con dilatación cervical entre 4 y 5 cm que se repartieron en de los grupos iguales de forma aleatoria. El Grupo I recibió anestesia peridural continua. El Grupo II recibió anestesia combinada. Se evaluaron: medidas antropométricas, edad de embarazo, dilatación cervical, tiempo entre el bloqueo y la ausencia de dolor a través de la escala analógica visual, posibilidad de deambulación, tiempo entre el inicio de la analgesia y la dilatación cervical completa, duración del período expulsivo, parámetros hemodinámicos maternos y vital edad del recién nacido. Posibles complicaciones como depresión respiratoria, hipotensión arterial materna, prurito, náuseas y vómitos también fueron observados. Para la comparación de los promedios se utilizó el teste t de Student y para la paridad y tipo de parto se utilizó el teste del Qui-cuadrado. RESULTADOS: No hubo diferencia estadística significativa entre los de los grupos con relación al tiempo entre el inicio de la analgesia y la dilatación cervical completa, como también con relación al tiempo de la duración del período expulsivo, incidencia de cesárea relacionada con la analgesia, parámetros hemodinámicos maternos y vital edad del recién nacido. CONCLUSIONES: Las dos técnicas fueron eficaces y seguras para la analgesia del trabajo de parto, aunque la técnica combinada haya

  15. The frequency of nasal injury in newborns due to the use of continuous positive airway pressure with prongs La frecuencia de lesión nasal en neonatos causada por la presión positiva continua en las vías aéreas con prongs Frequência de lesão nasal em neonatos por uso de pressão positiva contínua nas vias aéreas com pronga

    Directory of Open Access Journals (Sweden)

    Renata Medeiros do Nascimento

    2009-08-01

    Full Text Available Continuous positive airway pressure (CPAP with prongs is the ventilatory support most used in newborns. Nasal injuries are complications that may arise due to the prolonged use of this device. This study aimed to determine the frequency of nasal injuries in newborns through the use of continuous positive airway pressure with prongs. A convenience sample composed of hospitalized newborns using prongs for more than two days was used. Data were collected through a structured form. Lesions were observed in all newborns, which were classified as: mild (79.6%, moderate (19.7% and severe (0.7%. The conclusion is that the use of prongs for more than two days represents a risk factor for the lesions to develop.La presión positiva continua en las vías aéreas con prongs es la asistencia ventiladora más utilizada en neonatología. Las lesiones nasales son complicaciones que pueden surgir debido al uso prolongado de ese dispositivo. Este estudio tuvo por objetivo determinar la frecuencia de las lesiones nasales en neonatos causadas debido al uso de presión positiva continua en las vías aéreas utilizando un prong. El muestreo fue por conveniencia, constituido de recién nacidos internados y usando prongs, y se excluyeron aquellos que utilizaban el dispositivo por un período inferior a dos días. Los datos fueron recolectas a través de un formulario estructurado. Se observaron lesiones en todos los recién nacidos, clasificadas en: ligera (79,6%, moderada (19,7% y severa (0,7%. Se concluyó que el tiempo de permanencia de las prongs, por más de dos días, es un factor de riesgo para la evolución de las etapas de las lesiones nasales.A pressão positiva contínua nas vias aéreas com pronga é a assistência ventilatória mais utilizada em neonatologia. Lesões nasais são complicações que podem surgir pelo uso prolongado desse dispositivo. Este estudo objetivou determinar a frequência de lesões nasais em neonatos por uso de pressão positiva

  16. Remifentanil versus Sufentanil em infusão contínua em intervenções cirúrgicas videolaparoscópicas: estudo comparativo Remifentanil versus sufentanil en infusión continua en intervenciones quirúrgicas videolaparoscópicas: estudio comparativo Continuous infusion of remifentanil versus sufentanil in videolaparoscopic surgeries: a comparative study

    Directory of Open Access Journals (Sweden)

    Ricardo Francisco Simoni

    2008-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A infusão contínua (IC de remifentanil na técnica de anestesia venosa total é prática comum. Já o sufentanil em IC para cirurgias de curta/média duração tem sido pouco utilizado. O objetivo desse estudo foi comparar duas técnicas de anestesia venosa total, utilizando remifentanil ou sufentanil em IC, quanto ao comportamento anestésico no intra-operatório e às características da recuperação anestésica em pacientes submetidos à videolaparoscopia. MÉTODO: Participaram desse estudo 60 pacientes divididos em 2 grupos iguais (GR e GS. O GR foi induzido com remifentanil IC e o GS com sufentanil em bolus associado à IC. A IC de remifentanil era desligada ao fim da cirurgia, enquanto a IC de sufentanil, 20 minutos antes. Os pacientes receberam no intra-operatório cetoprofeno e dipirona. Como analgésico de resgate na sala de recuperação pós-anestésica (SRPA foi utilizado tramadol. Foram analisados as variações da pressão arterial média (PAM e freqüência cardíaca (FC, o tempo de despertar, o consumo de propofol, as intercorrências na SRPA e o tempo de permanência na SRPA. RESULTADOS: A média da PAM foi maior no GS em relação ao GR (91,9 × 77,6, p JUSTIFICATIVA Y OBJETIVOS: La infusión continua (IC de remifentanil en la técnica de anestesia venosa total es una práctica común. Ya el sufentanil en IC para cirugías de corta/media duración ha sido poco utilizado. El objetivo de este estudio fue el de comparar dos técnicas de anestesia venosa total, utilizando remifentanil o sufentanil en IC, en cuanto al comportamiento anestésico en el intraoperatorio y en cuanto a las características de la recuperación anestésica en pacientes sometidos a la videolaparoscopía. MÉTODO: Participaron en el estudio 60 pacientes divididos en 2 grupos iguales (GR y GS. El GR fue inducido con remifentanil IC y el GS con sufentanil en bolus asociado a IC. La IC de remifentanil se desconectaba al final de la

  17. Expenditure survey on continued veno-venous hemodialysis procedure in the intensive care unit Levantamiento del costo del procedimiento de hemodiálisis vena-venosa continua en unidades de terapia intensiva Levantamento do custo do procedimento de hemodiálise veno-venosa contínua em unidades de terapia intensiva

    Directory of Open Access Journals (Sweden)

    Lígia Maria dal Secco

    2007-12-01

    Full Text Available This study aimed to characterize patients submitted to dialytic treatment with CVVHD in ICUs; monitor procedure time duration; estimate nurses' labor wages and; estimate the direct procedures mean costs. The study was developed in a public teaching hospital located in São Paulo, Brazil. A total of 93 procedures performed in 50 patients composed the sample. The results showed the predominance of male patients (62%; mean age was 60.8 years old; ICU hospitalization time was 19.2 days; 86% of the patients died; 76% of the patients presented acute renal insufficiency and, mean procedure time per patient was 1.9. The mean procedure duration was 26.6 hours. The mean cost of nurses' wages were R$ 592.04 which represented 28.7% of the total cost. The mean total expenditure was R$ 2,065.36 ranging from R$ 733.65 to R$ 6,994.18.El objetivo de este estudio fue identificar características sócio-demográficas de los pacientes sometidos al tratamiento de Hemodiálisis Vena-Venosa Continua (CVVHD en Unidades de Terapia Intensiva (UTIs; identificar el tiempo de duración de los procedimientos; calcular el costo del tiempo de los enfermeros y evaluar el costo promedio directo de los procedimentos. El estudio fue realizado en un hospital escuela público en la ciudad de São Paulo. La muestra fue constituida por 93 procedimientos realizados en 50 pacientes. Los resultados mostraron la predominancia del sexo masculino (62%; la edad promedia fue de 60,8 años; el tiempo promedio de permanencia en la UTI fue de 19,2 días; el 86% evolucionó a óbito y el promedio del número de los procedimientos por paciente fue de 1,9 días. La insuficiencia renal aguda (IRA está presente en el 76% de los pacientes. La duración promedia fue de 26,6 horas. El costo del tiempo del enfermero fue en promedio R$ 592,04 y representó el 28,7% del costo total. El costo total promedio del procedimiento fue de R$ 2.065,36, con variación de R$ 733,65 a R$ 6.994,18.Os objetivos deste

  18. Analgesia peridural contínua: análise da eficácia, efeitos adversos e fatores de risco para ocorrência de complicações Analgesia peridural continua: análisis de la eficacia, efectos adversos y factores de riesgo para ocurrencia de complicaciones Continuous epidural analgesia: analysis of efficacy, side effects and risk factors

    Directory of Open Access Journals (Sweden)

    Leonardo Teixeira Domingues Duarte

    2004-06-01

    ,1%, 92,8% y 93,3% de la población estudiada. CONCLUSIONES: La analgesia peridural continua es efectiva y segura. Las complicaciones ocurridas no fueron consideradas graves. Todavía, no se puede dispensar rigurosa vigilancia a fin de obtenerse analgesia satisfactoria y diminuir las complicaciones.BACKGROUND AND OBJECTIVES: Epidural analgesia with local anesthetics and opioids has a reputation of high efficacy with low incidence of side effects. This study aimed at determining incidence, type and severity of postoperative complications related to epidural analgesia and catheter insertion. METHODS: Participated in this retrospective study 469 patients submitted to postoperative epidural analgesia in the period 10/18/99 to 10/18/01. Epidural analgesia was induced with 0.1% bupivacaine and fentanyl (1 to 5 µg.mL-1, at a 3 mL.h-1 rate. Infusion rate was adjusted according to patients' pain complaint. The following variables were evaluated: epidural infusion duration; incidence of side-effects and complications related to demographics, type of surgery and epidural catheter position; and quality of analgesia by means of a pain visual analog scale and a patients' satisfaction index. RESULTS: Epidural catheters remained in place 2.2 days in average, varying from 6 to 10 days. Global rate of technique-related complications was 46.3%, most of them minor complications without clinical repercussion. From these, 13.9% were directly related to the epidural catheter (disconnection, externalization, low back pain, inflammation and local infection. Other common complications were vomiting and urinary retention. Postoperative analgesia was effective in 97.2% of the patients which referred satisfaction with the technique. Patients without pain or slight pain during the first, second and third postoperative day represented 80.1%, 92.8% and 93.3%, respectively, of the studied population. CONCLUSIONS: Continuous epidural analgesia is effective and safe. Complications were not severe. However

  19. Astronomy Teaching and Teachers Continuing Education: the Interdisciplinarity during a Total Lunar Eclipse. (Spanish Title: Enseñanza de la Astronomía y la Formación Continua de Profesores: la Interdisciplinariedad Durante un Eclipse Total de Luna.) Educação EM Astronomia E Formação Continuada de Professores: a Interdisciplinaridade Durante um Eclipse Lunar TOTAL

    Science.gov (United States)

    Langhi, Rodolfo

    2009-07-01

    This paper describes how 67 teachers from 23 cities, could awaken, in students, the scientific interest, using a natural astronomical phenomenon: a total lunar eclipse. Before and after of eclipse, meetings for continuing education were characterized by interdisciplinarity of astronomy and the importance of these observations. Working groups were formed by teachers and students, who organized the survey data, mobilizing the people in their cities. The results point ways about how to provide the scientific culture and the motivation to learn science in students, using approaches between the following communities: scientific, amateur and school. En este artículo se describe cómo 67 profesores de 23 ciudades, despertó el interés científico en los estudiantes mediante un fenómeno astronómico: un eclipse total de Luna. Antes y después del eclipse, reuniones para la formación continua se centraron en la interdisciplinariedad de la astronomía, y la importancia de las observaciones de este tipo de fenómeno. Profesores y estudiantes formaron grupos de trabajo para investigar datos durante el eclipse, con el participación de la comunidad en sus ciudades. Los resultados apuntan a las opciones que conducen a la cultura científica y la motivación para aprender la ciencia, utilizando las relaciones de los siguientes grupos: científicos, aficionados y la escuela. Este texto relata como 67 professores, provenientes de 23 cidades, puderam despertar, nos alunos, o interesse científico utilizando um fenômeno natural astronômico: um eclipse lunar total. O evento foi precedido e procedido por encontros de formação continuada, onde se caracterizou a interdisciplinaridade da astronomia e a importância das observações de fenômenos como estes. Grupos de trabalho foram formados por professores e alunos, que se organizaram para o levantamento conjunto de dados durante o fenômeno, além do envolvimento da comunidade em suas respectivas cidades. Os resultados apontam

  20. Museum-school interactions: the importance of continuing education programs for teachers in municipalities away from urban centres Interaction musée-école : l’importance des programmes de formation continue des enseignants dans les municipalités éloignées des centres urbains Interacción museo-escuela : la importancia de los programas de formación continua de profesores en localidades alejadas de los centros urbanos

    Directory of Open Access Journals (Sweden)

    Grazielle Rodrigues Pereira

    2011-09-01

    de una serie de conceptos equivocados respecto a la ciencia, los centros y museos de ciencias surgen con propuestas para romper con el paradigma de la ciencia accesible solo a una pequeña parte de la población. Estos espacios desarrollan actividades con fines de inclusión social en función de su carácter educativo, y así invierten, entre otras acciones, en estrategias para la actualización de los profesionales de la educación. La mayor parte de estos espacios se concentran aún en los grandes centros urbanos, dificultando la participación de las clases sociales menos favorecidas. Este trabajo presenta un programa piloto de formación continua de profesores desarrollado por el Espaço Ciência InterAtiva del IFRJ (Instituto Federal de Río de Janeiro, un museo de ciencias ubicado en una región periférica de Rio de Janeiro, demostrando así que una exposición científica puede contribuir a la inserción de los docentes en los espacios de educación no formal, así como a la formación continua de los mismos.Em virtude de uma série de concepções equivocadas a respeito da ciência, os centros e museus de ciências surgem com propostas de romper com o paradigma da ciência voltada para uma pequena parcela da população. Esses espaços desenvolvem atividades com vistas à inclusão social em função do seu caráter educacional, e com isso investem, entre outras ações, em estratégias de atualização do profissional da educação. Todavia, a maior parte desses espaços concentra-se nos grandes centros urbanos, dificultando a participação das camadas menos favorecidas da sociedade. Dessa forma, o presente trabalho apresenta o relato de um programa piloto de formação continuada de professores, desenvolvido pelo Espaço Ciência InterAtiva do IFRJ, um museu de ciências localizado em uma região periférica do Rio de Janeiro, demonstrando assim que uma exposição científica pode contribuir para a inserção dos docentes nesses espaço de educação n

  1. Comparação entre raquianestesia, bloqueio combinado raqui-peridural e raquianestesia contínua para cirurgias de quadril em pacientes idosos: estudo retrospectivo Comparación entre raquianestesia, bloqueo combinado raqui-peridural y raquianestesia continua para cirugías de cuadril en pacientes ancianos: estudio retrospectivo Comparison between spinal, combined spinal-epidural and continuous spinal anesthesias for hip surgeries in elderly patients: a retrospective study

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Imbelloni

    2002-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Diversas questões envolvem os estudos, as análises e o tamanho da amostra para que sejam demonstrados os benefícios da anestesia regional. Análise de dados geralmente custa menos e requer menos tempo quando comparado com amplo estudo aleatório controlado. Esta análise retrospectiva compara a raquianestesia contínua, o bloqueio combinado raqui-peridural e a raquianestesia simples para cirurgias de quadril em pacientes idosos durante quatro anos, para determinar as possíveis vantagens e desvantagens das três técnicas. MÉTODO: Foram avaliados 300 prontuários sendo que: 100 pacientes receberam raquianestesia simples (Grupo 1, 100 receberam bloqueio combinado raqui-peridural (Grupo 2 e 100 receberam raquianestesia contínua (Grupo 3 nos últimos quatro anos. Todos os bloqueios foram realizados em decúbito lateral esquerdo. Foram avaliados: sucesso de punção, nível da analgesia, bloqueio motor de membros inferiores, qualidade da anestesia, necessidade de complementação, incidência de falhas, parestesias, cefaléia pós-punção, alterações cardiovasculares, confusão mental e delírio, transfusão sangüínea e mortalidade. RESULTADOS: Não existiu diferença significativa entre os grupos em relação a idade, peso e sexo. Os pacientes do grupo 2 foram menores do que os do grupo 1 e 3. As doses utilizadas foram de 15,30 mg de bupivacaína no grupo 1; 23,68 mg no grupo 2 e 10,10 mg no grupo 3. Não foi encontrada diferença significativa (p JUSTIFICATIVA Y OBJETIVOS: Diversas cuestiones envuelven los estudios, las análisis y el tamaño de la muestra para que sean demostrados los beneficios de la anestesia regional. Las análisis de datos generalmente cuestan menos y requieren menos tiempo, cuando comparado con un amplio estudio aleatorio controlado. Esta análisis retrospectiva compara la raquianestesia continua, el bloqueo combinado raqui-peridural y la raquianestesia simple para cirugías de cuadril en

  2. Percepção da equipe de enfermagem acerca de um serviço de educação continuada de um hospital universitário Percepción del equipo de enfermería sobre un servicio de la educación continua de un hospital de universitario Perception of the nursing staff about service of continuing education of a university hospital

    Directory of Open Access Journals (Sweden)

    Aline Togni Braga

    2009-12-01

    Full Text Available O objetivo deste estudo foi analisar o Serviço de Educação Continuada (SEC de um hospital de ensino, sob a ótica da equipe de enfermagem, nas dimensões avaliativas de estrutura, de processo e de resultado. Trata-se de um estudo exploratório descritivo, realizado em hospital universitário privado. Para a coleta de dados utilizou-se um instrumento composto por uma escala de Likert. O tratamento dos dados foi realizado por meio da estatística descritiva e pelo emprego do teste Alpha de Cronbach. Na análise dos resultados, observou-se que nas três dimensões avaliativas (estrutura, processo e resultado a equipe de enfermagem teve percepção favorável quanto às atividades desenvolvidas por este serviço. Entretanto, na comparação, a que obteve maior escores de favorabilidade foi a de estrutura, média de 42,56 (dp±4,97 e o menor a de processo, média 40,44 (dp±5,11.Lo objetivo de este estudio fue analizar el Servicio de la Educación de Continua (SEC de un hospital universitario, de la perspectiva del equipo del oficio de enfermera en la evaluación de las dimensiones de estructura, proceso y resultados. Esto es un estudio exploratorio-descriptivo, ejecutado en un hospital de enseñanza privado. La colección de datos fue conducida a través de un cuestionario, usando una escala de Likert. El tratamiento de los datos fue llevado con las estadísticas descriptivas usando la prueba alfa de Cronbach. Analizando los datos, observamos que en el árbol evaluó las dimensiones (estructura, proceso y resultado la enfermera que el equipo tenía opinión favorable concerniente a este servicio. Sin embargo, la dimensión de la estructura recibió la cuenta más alta del favorability, promedio de 42.56 (dp±4,97, con la dimensión de proceso recibiendo la cuenta más baja de, el promedio 40.44 (dp±5,11.The objective of this study was to analyze the Service of Continuated Education (SCE of a university hospital, from the perspective of the

  3. Forms of Appropriation of Tools for the Astronomy Education in Continuous Training of Teachers. (Spanish Title: Formas de Apropriación de Herramientas Para la Enseñanza de la Astronomía en la Formación Docente Continua.) Formas de Apropriação de Instrumentos Para o Ensino de Astronomia na Formação Continuada de Professores

    Science.gov (United States)

    Marques Soares, Leonardo; Sousa Nascimento, Silvania

    2012-07-01

    The main focus of this article is to present some impressions about the way some teachers appropriated of the tools from the ASTRONOMY TEACHING KIT (KITPEA). The subjects of this research were teachers that took part in the astronomy teaching specialization course offered by the Continuing Education Project (FOCO) at Math and Science Teaching Center (CECIMIG) from the School of Education of Federal University of Minas Gerais (FaE/UFMG). The data was collected with the use of a questionnaire and of an interview applied to these teachers. The analysis of the data was structured with the aid of the Activity Theory and the Mediated Action Theory. We interpret the teachers' speech using the constitutive aspects of the activity system and the concepts of appropriation and domain as an analytical device. It was possible to recognize the appropriation of the tools in 7 narratives among the 11 individuals who took part in the research. El objetivo principal de ese artículo es presentar indicaciones sobre la manera como algunos maestros se apropiaron de las herramientas del KIT PARA LA ENSEÑANZA DE LA ASTRONOMÍA (KITPEA). Los sujetos de esa investigación son docentes que participaron del curso de especialización en enseñanza de astronomía ofrecido por el Proyecto de Formación Continua (Foco) en el Centro de Enseñanza de Ciencias y Matemática (CECIMIG) de la Facultad de Educación de la Universidad Federal de Minas Gerais (FaE/UFMG). Recogimos las informaciones a través de un cuestionario y de una encuesta, aplicados a esos docentes. Estructuramos el análisis de esas informaciones con la ayuda de la Teoría de la Actividad y de la Teoría de la Acción Mediada. Interpretamos os discursos de los docentes usando como dispositivo analítico los elementos constitutivos del sistema de actividad y los conceptos apropiación y dominio. Entre los 11 sujetos que participaron de la investigación, fue posible interpretar con claridad la apropiación de las herramientas en

  4. Fostering Organizational Innovation based on modeling the Marketing Research Process through Event-driven Process Chain (EPC

    Directory of Open Access Journals (Sweden)

    Elena Fleacă

    2016-11-01

    Full Text Available Enterprises competing in an actual business framework are required to win and maintain their competitiveness by flexibility, fast reaction and conformation to the changing customers' needs based on innovation of work related to products, services, and internal processes. The paper addresses these challenges which gain more complex bonds in a case of high pressure for innovation. The methodology commences with a literature review of the current knowledge on innovation through business processes management. Secondly, it has been applied the Event-driven Process Chain tool from the scientific literature to model the variables of marketing research process. The findings highlight benefits of marketing research workflow that enhances the value of market information while reducing costs of obtaining it, in a coherent way.

  5. Conserving gallons and kilowatts. Challenges of today's solar power plants. An EPC (Engineering, Procurement and Construction) perspective

    Energy Technology Data Exchange (ETDEWEB)

    Shoemaker, Jeanette [Ivanpah Solar Electric Generating Facility, CA (United States); Bechtel Power Corp., Frederick, MD (United States); Huth, Christopher; Sinha, Kumar [Bechtel Power Corp., Frederick, MD (United States)

    2013-03-15

    With the increasing restrictions on CO2 emissions, the utilization of solar power is emerging as an effective way to increase the renewable portfolio for utility power. For example in California, the utilities' current renewable portfolios must increase from 20% to 33% by 2020. This drive has made renewable power considerably more desirable. However, fresh water availability and optimal solar irradiation are generally two mutually exclusive local characteristics that make locating and designing these plants challenging. Not only is fresh water scarce at the desert locations where these solar plants are generally located, but options for disposal of wastewater can be very limited as well. These factors have pushed the design of these plants to develop a fine balance between conserving and reusing water to the greatest extent practical and reducing parasitic electrical loads. This paper addresses the challenges associated with developing solar power plant designs that optimize house electrical load while minimizing water footprint. Through the implementation of operational water management techniques and optimized water treatment processes, water usage can be reduced to manageable levels. Utilizing systems that recover and recycle wastewater, the system can be further optimized to reduce the overall water footprint. Case studies are presented for multiple sites detailing the individual optimization required based on the water quality provided. Lessons learned during plant siting and permitting are provided to shed light on the current issues associated with wastewater disposal in these areas and utilization of evaporation ponds. In addition, various design philosophies are discussed to guide the reader through the difficulties of determining the right mix of initial capital cost, optimized water usage, minimized operating cost and minimized parasitic electrical load. (orig.)

  6. Hraboš - významný škůdce v řepce

    Czech Academy of Sciences Publication Activity Database

    Heroldová, Marta; Zejda, Jan

    2014-01-01

    Roč. 2014, č. 2 (2014), s. 48-49 ISSN 1801-7673 R&D Projects: GA MŠk EE2.3.35.0026 Institutional support: RVO:68081766 Keywords : common vole * rape Subject RIV: GF - Plant Pathology, Vermin, Weed , Plant Protection

  7. Analysis on optimization of the critical path for civil construction period of Fangjiashan nuclear island constructed under EPC mode

    International Nuclear Information System (INIS)

    Liu Yongqing; Wu Youcong; Qiu Jinhong

    2011-01-01

    Based on the actual situation of nuclear island civil construction in Fangjiashan nuclear power plant and combined with the arrangement of the construction schedule, the analysis on optimization of the critical path for civil construction period is conducted. The result shows that on the premise of not increasing the contract price and the total engineering cost based on the original 57-month construction period, the construction period can be shorten to 21 month through strengthening the schedule control, keeping the critical work in a reasonable duration and rearranging the link between programmers. In addition, in view of the economic analysis, if we increase the mechanical engagement and adopt special method, the 2-month construction period can be even shortened to 20 months. (authors)

  8. Integrated Cost and Schedule Control Systems for Nuclear Power Plant Construction: Leveraging Strategic Advantages to Owners and EPC Firms

    Directory of Open Access Journals (Sweden)

    Youngsoo Jung

    2015-01-01

    Full Text Available As the owners expect that the cost and time for nuclear power plant construction would decrease with new entrants into the market, there will be severer competition in the nuclear industry. In order to achieve performance improvement and to attain competitive advantages under the globalized competition, practitioners and researchers in the nuclear industry have recently exerted efforts to develop an advanced and efficient management methodology for the nuclear mega-projects. Among several candidates, integrated cost and schedule control system is of great concern because it can effectively manage the three most important project performances including cost, time, and quality. In this context, the purpose of this paper is to develop a project numbering system (PNS of integrated cost and schedule control system for nuclear power plant construction. Distinct attributes of nuclear power plant construction were investigated first in order to identify influencing variables that characterize real-world implementation of advanced cost and schedule controls. A scenario was then developed and analysed to simulate a case-project. By using this case-project, proposed management requirements, management methods, measurement techniques, data structure, and data collection methods for integrated cost and schedule PNS were illustrated. Finally, findings and implications are outlined, and recommendations for further research are presented.

  9. Efeitos da pressão positiva contínua nas vias aéreas na insuficiência cardíaca crônica Efectos de la presión positiva continua en las vías aéreas en la insuficiencia cardíaca crónica Effects of the continuous positive airway pressure on the airways of patients with chronic heart failure

    Directory of Open Access Journals (Sweden)

    João Carlos Moreno de Azevedo

    2010-07-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca pode apresentar disfunção assintomática à descompensação, com limitações e diminuição da capacidade produtiva. A pressão positiva contínua nas vias aéreas (CPAP é um meio não farmacológico de redução da pós-carga. OBJETIVO: Analisar os efeitos da CPAP (10 cmH2O, por 30 dias, em paciente com insuficiência cardíaca crônica. MÉTODOS: Avaliamos 10 pacientes, com diversas etiologias, idade média de 54 ± 14 anos, sexo (masc.= 6 e fem.= 4, com IMC de 21 ± 0,04 kg/m². A terapia foi ofertada por 60 min., 5 vezes por semana, durante 1 mês, no período diurno. Foram analisados ecocardiograma e ergoespirometria, antes e após 30 dias de terapia. RESULTADOS: Apresentou aumento de 19,59% na fração de ejeção do ventrículo esquerdo (FEVE: 23.9 ± 8.91 vs 27.65 ± 9.56%; p = 0,045. Na ergoespirometria, o tempo de exercício (Tex apresentou aumento significante de 547 ± 151,319 vs 700 ± 293,990 seg., p = 0,02, o consumo de oxigênio (VO2 foi de 9,59 ± 6,1 vs 4,51 ± 2,67 ml.kg-1.min.-1 , p = 0,01, enquanto a produção de dióxido de carbono (VCO2 de repouso (9,85 ± 4,38 vs 6,44 ± 2,88 ml.kg-1.min.-1 , p = 0,03 apresentou diminuição. CONCLUSÃO: A CPAP provocou aumento na fração de ejeção do ventrículo esquerdo e no tempo de exercício, diminuiu o consumo de oxigênio e a produção de dióxido de carbono no repouso.FUNDAMENTO: La insuficiencia cardíaca puede presentar disfunción asintomática a la descompensación, con limitaciones y disminución de la capacidad productiva. La presión positiva continua en las vías aéreas (CPAP es un medio no farmacológico de reducción de la post-carga. OBJETIVO: Analizar los efectos de la CPAP (10 cmH2O, por 30 días, en paciente con insuficiencia cardíaca crónica. MÉTODOS: Evaluamos 10 pacientes, con diversas etiologías, edad media de 54 ± 14 años, sexo (masc.= 6 y fem.= 4, con IMC de 21 ± 0,04 kg/m². La terapia fue ofertada por

  10. Psicologias sociais cientificista e crítica: um debate que continua

    Directory of Open Access Journals (Sweden)

    Mariana Prioli Cordeiro

    Full Text Available Diversos autores falam de ao menos duas versões da Psicologia social: uma anterior e outra posterior à crise de referência que assolou essa área do conhecimento na década de 70. A primeira tinha uma base positivista, já a segunda se caracterizava por defender uma ciência comprometida com a transformação social. Em geral, esses textos narram a história da Psicologia social destacando personagens, acontecimentos e ideários. Neste artigo, seguindo a proposta da teoria ator-rede, acrescentamos novos elementos a essa história e falamos dos atores humanos e não humanos, das materialidades e socialidades, que contribuíram para construir a Psicologia social brasileira. Concluímos o texto argumentando que a crise de referência não eliminou por completo a Psicologia social positivista, substituiu-a por uma vertente crítica, pois, ainda hoje, ambas coexistem. Argumentamos, portanto, que a Psicologia social brasileira é complexa, e que essa complexidade não cabe na tênue linha do tempo que muitas vezes traçamos para representar o desenvolvimento de disciplinas acadêmicas.

  11. Size effects in two-dimensional Voronoi foams : A comparison between generalized continua and discrete models

    NARCIS (Netherlands)

    Tekoglu, Cihan; Onck, Patrick R.

    2008-01-01

    In view of size effects in cellular solids, we critically compare the analytical results of generalized continuum theories with the computation a I results of discrete models. Representatives are studied from two classes of generalized continuum theories: the strain divergence theory from the class

  12. Experimental micro mechanics methods for conventional and negative Poisson's ratio cellular solids as Cosserat continua

    Science.gov (United States)

    Lakes, R.

    1991-01-01

    Continuum representations of micromechanical phenomena in structured materials are described, with emphasis on cellular solids. These phenomena are interpreted in light of Cosserat elasticity, a generalized continuum theory which admits degrees of freedom not present in classical elasticity. These are the rotation of points in the material, and a couple per unit area or couple stress. Experimental work in this area is reviewed, and other interpretation schemes are discussed. The applicability of Cosserat elasticity to cellular solids and fibrous composite materials is considered as is the application of related generalized continuum theories. New experimental results are presented for foam materials with negative Poisson's ratios.

  13. Espacios para el arte: lugares en continua redefinición

    Directory of Open Access Journals (Sweden)

    Eloísa Alisal

    2007-12-01

    Full Text Available Através de la historia del museo y del coleccionismo han ido proliferando una gran variedad de espacios en los que se cobijan, conservan, resguardan o almacenan los objetos de interés cultural y, a pesar de esto, el patrimonio artístico de las comunidades ha continuado siendo soporte de su memoria como colectividad. Desde los santuarios griegos dedicados a las Musas hasta los museos y centros de arte actuales, las colecciones artísticas cobijadas se han transformado en soporte para la transmisión de ideas y de conocimientos. Tanto los espacios físicos (templos, academias, galerías, palacios y salones como los espacios virtuales (museos y galerías en red han mantenido la misma finalidad: conservar, estudiar y difundir las manifestaciones artísticas de las culturas. Han pasado más de dos siglos desde la creación del primer museo de arte contemporáneo concebido como lugar de conservación, estudio y difusión del arte creado en su contemporaneidad; y más de un siglo desde que Duchamp incluyera su obra “Fuente” en el Armory Show, desde entonces el museo de arte se redefine junto al objeto que debería cobijar.

  14. Red continua de espacios públicos verdes a escala municipal: el caso de Madrid

    OpenAIRE

    Casado Postigo, Pablo

    2015-01-01

    La ubicación marginal y el aislamiento de los Parques Urbanos implican infrautilización y deterioro de los mismos. Su interconexión mediante una red verde peatonal con limitaciones al tráfico rodado, supone una puesta en valor de todo el sistema de espacios libres y zonas verdes de la ciudad y un importante incentivo para desviar determinados flujos rodados a otras vías cercanas, rescatando así, espacios urbanos a favor del peatón. Esta conexión ayuda a minimizar la fragmentación del espacio ...

  15. O Espírito do Cristianismo e seu Destino (Continuação

    Directory of Open Access Journals (Sweden)

    G. W. F. Hegel

    2017-02-01

    Full Text Available Tradutor: Adilson Felício Feiler, SJ, Doutorando em Filosofia pela PUCRS. E-mail: feilersj@yahoo.com.br. Revisão de Agemir Bavaresco (PUCRS, Francisco Jozivan Guedes (PUCRS e Paulo Roberto Konzen (UFRGS. A tradução de O Espírito do Cristianismo e o seu Destino (Der Geist des Christentums und sein Schicksal, que ora segue, constitui, no dizer de Dilthey, uma das mais belas passagens escritas por Hegel. No entanto, é questionável se a obra constitui um todo acabado, já que Hegel interrompeu várias vezes sua redação, deixando linhas em branco e reiniciando o parágrafo com uma nova linha de pensamento. Mas, Nohl juntou em um texto homogêneo um composto de cinco fragmentos separados (N, 243-60, 261-75, 276-301, 302-24, 325-42. Pelas pesquisas de G. Schüler e Ch. Jamme, a obra se desenvolve em duas fases distintas, tendo como ponto de partida o outono/inverno de 1798 para 1799, em Frankfurt. É neste período que Hegel procura desvendar a origem da positividade das leis morais religiosas judaicas que o cristianismo procura superar pelo amor. Pelo espírito do cristianismo, Hegel ensaia uma resposta à questão da unidade, que passa a ser veiculada pelos impulsos naturais da vontade. É, por isso, este um período hegeliano denominado de período anímico. Estão traduzidas, em princípio, apenas as páginas iniciais da obra, em que Hegel apresenta Jesus como aquele que se levanta contra as leis judaicas. A tradução é da seguinte edição alemã: HEGEL, G. W. F. Frühe Schriften. Werk 1. Suhrkamp Taschenbuch Wissenschaft: Frankfurt am Main, 1994, p. 346-369. Esta terceira parte da tradução apresenta a crítica de Hegel à positividade da religião judaica. Tal positividade vem expressa através da lei, que coloca o humano numa posição de subserviência e passividade. Diante desta situação Hegel reconhece a atuação de Jesus de Nazaré, aquele que se levanta frente às incoerências do judaísmo.

  16. Efeito Agudo da Pressao Positiva Continua sobre a Pressao de Pulso na Insuficiencia Cardiaca Cronica

    Directory of Open Access Journals (Sweden)

    Monica Quintao

    2014-03-01

    Full Text Available Fundamento: Pacientes com insuficiência cardíaca (IC apresentam disfunção ventricular esquerda e redução da pressão arterial média (PAM. O aumento do estímulo adrenérgico causa vasoconstrição e resistência dos vasos, mantendo a PAM, enquanto aumenta a resistência vascular periférica e a rigidez dos vasos condutores. O aumento da pressão de pulso (PP reflete a complexa interação do coração com os sistemas arteriais e venosos. O aumento da PP é um importante marcador de risco em pacientes com insuficiência cardíaca crônica (ICC. A ventilação não invasiva (VNI tem sido utilizada para IC aguda descompensada para melhorar a congestão e a ventilação pelos efeitos respiratórios e hemodinâmicos. No entanto, nenhum desses estudos relatou o efeito da VNI na PP. Objetivo: O objetivo deste estudo foi determinar os efeitos agudos da VNI com CPAP (pressão positiva contínua nas vias aéreas sobre a PP em pacientes ambulatoriais com ICC. Métodos: Seguindo um protocolo randomizado, duplo-cego, cruzado e controlado com placebo, 23 pacientes com ICC (17 homens, 60 ± 11 anos, IMC 29 ± 5 kg/cm2, classes II e III da NYHA foram submetidos à CPAP via máscara nasal durante 30 minutos na posição reclinada. A pressão da máscara foi de 6 cmH2O, enquanto o placebo foi fixado em 0-1 cmH2O. PP e outras variáveis hemodinâmicas não invasivas foram avaliadas antes, durante e depois do placebo e do modo CPAP. Resultados: A CPAP diminuiu a frequência cardíaca de repouso (pré: 72 ± 9; pós 5 min: 67 ± 10 bpm , p < 0,01 e PAM (CPAP: 87 ± 11; controle 96 ± 11 mmHg , p < 0,05 pós 5 min. A CPAP diminuiu a PP (CPAP: 47 ± 20 pré para 38 ± 19 mmHg pós; controle: 42 ± 12 mmHg, pré para 41 ± 18 pós p < 0,05 pós 5 min. Conclusão: A VNI com CPAP diminuiu a pressão de pulso em pacientes com ICC estável. Ensaios clínicos futuros devem investigar se esse efeito está associado com melhora no desfecho clínico.

  17. The Energy and Identification Continua of Burnout and Work Engagement : Developmental Profiles Over Eight Years

    OpenAIRE

    Mäkikangas, Anne; Hyvönen, Katriina; Feldt, Taru

    2017-01-01

    Understanding of the mutual developmental dynamics between burnout and work engagement is limited due to the lack of longitudinal studies with long follow-ups and multi-wave data. This study sought to identify subgroups of employees characterized by long-term exhaustion-vigor (energy continuum) and cynicism-dedication (identification continuum). A further important aim was to investigate differences between the identified subgroups in their experiences of progress in their personal work goals...

  18. Física y química: 1 Bachillerato. Corriente eléctrica continua

    OpenAIRE

    Carrascosa Alís, Jaime; Martínez Sala, Salvador; Martínez-Torregrosa, Joaquín

    1998-01-01

    Se supone que los alumnos han realizado los temas "Otra propiedad general de la materia: la carga eléctrica" (http://hdl.handle.net/10045/9859) y "Átomos por dentro" (http://hdl.handle.net/10045/9900), y que se dispone del tiempo necesario para hacer bien el tema. Es un tema adecuado para Primer curso universitario (¡siempre que se busque la comprensión y no "el hacer muchos ejercicios de Kirchoff"). El libro de Chabay & Sherwood fue una gran ayuda para nuestra comprensión de los circuitos. ¡...

  19. Prácticas de Física: Circuitos de corriente continua

    OpenAIRE

    Beléndez, Augusto; Bernabeu, Guillermo; Vera Guarinos, Jenaro; Pastor Antón, Carlos; Martín García, Agapito

    1988-01-01

    Esta práctica tiene como objetivo familiarizar al alumno con el uso del voltímetro y el amperímetro, realizando cálculos teóricos sobre los circuitos montados con resistencias en serie y en paralelo, y comparando los resultados teóricos con los experimentales. En primer lugar se diseña un circuito en el que las tres resistencias empleadas se encuentran en serie. El alumno debe realizar por un lado el cálculo teórico de la intensidad que circula por el circuito utilizando la ley de Ohm, así co...

  20. Mejora de la calidad del acero obtenido por colada continua mediante influencias electrofísicas

    Directory of Open Access Journals (Sweden)

    Shklyar, V.

    1998-12-01

    Full Text Available Laboratory tests with tin smelted in a crucible and industrial tests with crude steel poured in moulds had been carried out. These metals were subjected to electrophysical influences. As a result of the applied electric field, it is observed in tin that during the solidification, the crystalization temperature and the solidification time are changed. Crystal growth in the electric field direction and an increase of the fracture limit in the steel ingot are observed.

    Se han realizado ensayos de laboratorio con estaño fundido en crisol y a escala industrial con acero líquido vertidos en moldes, sometiendo estos metales a influencias electrofísicas. Como resultado del campo aplicado, en el estaño se observa que durante la solidificación varía la temperatura de cristalización y el tiempo de solidificación. En el lingote de acero se observa un crecimiento de los cristales en dirección del campo eléctrico y un aumento del límite de rotura.

  1. Continuous improvement in manufacturing and inspection of fuel; Mejora continua en fabricacion e inspeccion de combustible

    Energy Technology Data Exchange (ETDEWEB)

    Domingon, A.; Ruiz, R.

    2015-07-01

    The manufacturing and inspection process of fuel assemblies in ENUSA is characterized by its robustness acquired over the last thirty years of experience in manufacturing. The reliability of these processes is based on a qualified processes and continuous improvement in the design and upgrading of equipment and optimization of software and manufacturing processes. Additionally, management and quality control systems have been improved in both software and measuring business objectives. this article emphasizes the improvements made over the past five years in management, production and inspection of fuel assemblies. (Author)

  2. A Two-Continua Approach to Eulerian Simulation of Water Spray

    DEFF Research Database (Denmark)

    Nielsen, Michael Bang; Østerby, Ole

    2013-01-01

    Physics based simulation of the dynamics of water spray - water droplets dispersed in air - is a means to increase the visual plausibility of computer graphics modeled phenomena such as waterfalls, water jets and stormy seas. Spray phenomena are frequently encountered by the visual effects industry...

  3. Narrow Radiative Recombination Continua: A Signature of Ions Crossing the Contact Discontinuity of Astrophysical Shocks

    Science.gov (United States)

    Behar, Ehud; Nordon, Raanan; Soker, Noam; Kastner, Joel H.; Yu, Young Sam

    2009-01-01

    X-rays from planetary nebulae (PNs) are believed to originate from a shock driven into the fast stellar wind (v 1000 kilometers per second) as it collides with an earlier circumstellar slow wind (v 10 kilometers per second). In theory, the shocked fast wind (hot hubble) and the ambient cold nebula can remain separated by magnetic fields along a surface referred to as the contact discontinuity (CD) that inhibits diffusion and heat conduction. The CD region is extremely difficult to probe directly owing to its small size and faint emission. This has largely left the study of CDs, stellar-shocks, and the associated micro-physics in the realm of theory. This paper presents spectroscopic evidence for ions from the hot bubble (kT approximately equal to 100 eV) crossing the CD and penetrating the cold nebular gas (kT approximately equal to 1 eV). Specifically, a narrow radiative recombination continuum (RRC) emission feature is identified in the high resolution X-ray spectrum of the PN BD+30degree3639 indicating bare C VII ions are recombining with cool electrons at kT(sub e) = 1.7 plus or minus 1.3 eV. An upper limit to the flux of the narrow RRC of H-like C VI is obtained as well. The RRCs are interpreted as due to C ions from the hot bubble of BD+30degree3639 crossing the CD into the cold nebula, where they ultimately recombine with its cool electrons. The RRC flux ratio of C VII to C VI constrains the temperature jump across the CD to deltakT greater than 80 eV, providing for the first time direct evidence for the stark temperature disparity between the two sides of an astrophysical CD, and constraining the role of magnetic fields and heat conduction accordingly. Two colliding-wind binaries are noted to have similar RRCs suggesting a temperature jump and CD crossing by ions may be common feature of stellar wind shocks.

  4. El uso de la plataforma virtual en la evaluación continua

    Directory of Open Access Journals (Sweden)

    Asunción Serrano Domínguez

    2010-01-01

    Full Text Available Utilizar una herramienta como la plataforma virtual en mi día a día, como docente de E/LE, sería una idea que hace unos años me hubiera parecido una locura. Por ese motivo, considero necesario volver la vista atrás hasta el momento que propició un cambio sin retorno en mi forma de trabajar y en mi concepción de la enseñanza de E/LE. Permítanme que utilice como recurso una historia de vida que comenzó en el año 2008, cuando una compañera de departamento, a quien acababa de conocer, me propuso pilotar una unidad didáctica, entregada en papel, de una doctoranda 1 de la Universidad Carlos III de Madrid. Confieso que en ese momento, recién llegada a mi actual centro de trabajo, mi mayor inquietud a nivel técnico, era saber dónde encontrar tizas en caso de que estas se acabaran. Como podrán imaginar, tras recibir tal encargo, lo primero que se me ocurrió fue intentar dinamizar las actividades propuestas en el papel, para lograr primero, una mayor motivación de los alumnos, y después, una práctica equitativa de destrezas. En ese momento, comencé una labor de investigación a nivel técnico, para conocer los materiales y el equipamiento disponible en mi centro de trabajo. A partir de este momento, fui consciente de la necesidad de ser autónoma, en cuanto a equipamiento multimedia y realicé una inversión personal consistente en una mochila con ruedas, un ordenador portátil, un pequeño altavoz de gran potencia y un,imprescindible, alargador. Asimismo, completé este viaje, con toda una serie deformaciones y de autoformaciones que, actualmente, me permiten utilizar las TIC, a medida de la programación de mis asignaturas y del beneficio que estas pueden aportar al proceso de aprendizaje de los alumnos que en ellas se matriculan.

  5. The ultraviolet to X-ray continua of BL Lac objects

    International Nuclear Information System (INIS)

    George, I.M.; Warwick, R.S.; McHardy, I.M.

    1988-01-01

    The results from EXOSAT observations of three X-ray bright BL Lacertae objects, Mrk 501, 1218 + 304 and Mrk 180 are presented. All three sources have soft power-law X-ray spectra with low-energy cut-offs consistent with absorption in the line-of-sight gas column density through our own galaxy. The three objects also exhibit significant spectral variability in the X-ray band on time-scales ranging from a few days to a year. In each case, X-ray flux and spectral index appear to be correlated, in the sense that the X-ray spectrum hardens as the source brightens. The intrinsic ultraviolet to X-ray spectrum of these and several other X-ray bright BL Lac objects can be modelled as a power-law continuum of energy index ∼1.0 below about 0.1 keV, above which the spectral slope steepens. (author)

  6. Nuevos horizontes formativos: una experiencia del MOOC como recurso en la formación continua

    Directory of Open Access Journals (Sweden)

    Alicia Benet Gil

    2018-03-01

    Full Text Available Debido a la actual incorporación de la educación virtual en el mundo educativo, este trabajo presenta el diseño y la evaluación del massive online open course (MOOC denominado “El aula inclusiva hoy en día. Cómo afrontar el trastorno del espectro autista y las altas capacidades intelectuales”, a fin de proporcionar a los profesionales de la educación un recurso formativo más accesible y flexible para que puedan ampliar y reforzar conocimientos. El objeto es conocer la percepción de los participantes sobre el citado trastorno mediante un cuestionario utilizado como instrumento para recoger los datos. En el curso se inscribieron 330 participantes, de los cuales 110 lo terminaron de manera satisfactoria y respondieron al cuestionario final evaluativo. La mayoría de los sujetos contestaron positivamente la totalidad de las preguntas y quedaron satisfechos, en general, en su temática, contenido, metodología y participación. La principal aportación de este trabajo radica en la potencialidad de estos cursos como una herramienta accesible que permite la formación permanente de los profesionales relacionados, en este caso, con la educación. Como propuesta de mejora los participantes apuntan a aumentar el número de tiempo para realizar las tareas. Como conclusión, se percibe el MOOC como una herramienta satisfactoria. Esto sirve para seguir avanzando en el terreno de la formación en línea y a distancia, considerando los MOOC como herramientas poderosas que propician un canal valioso de intercambio de contenidos y saberes por parte del estudiantado procedente de cualquier lugar del mundo.

  7. The energy and identification continua of burnout and work engagement: Developmental profiles over eight years

    Directory of Open Access Journals (Sweden)

    Anne Mäkikangas

    2017-06-01

    Full Text Available Understanding of the mutual developmental dynamics between burnout and work engagement is limited due to the lack of longitudinal studies with long follow-ups and multi-wave data. This study sought to identify subgroups of employees characterized by long-term exhaustion-vigor (energy continuum and cynicism-dedication (identification continuum. A further important aim was to investigate differences between the identified subgroups in their experiences of progress in their personal work goals. Five-wave, eight-year follow-up data among Finnish white-collar professionals (n = 168 were studied using Latent Profile Analysis (LPA. The analysis yielded three exhaustion-vigor subgroups: 1 “Low stable exhaustion – high stable vigor” (n = 141, 2 “Fluctuating exhaustion and vigor” (n = 19, and 3 “Stable average exhaustion – decreasing vigor” (n = 8. Three subgroups were also found for cynicism-dedication: 1 “Low stable cynicism – high stable dedication” (n = 124, 2 “Increasing cynicism – decreasing dedication” (n = 27, and 3 “Decreasing cynicism – increasing dedication” (n = 17. Exhaustion and vigor were found to be stable and mutually exclusive experiences for the great majority of the participants. However, mean changes were also detected – especially in vigor – but these were rare. A notable finding was that the levels of and changes in cynicism and dedication showed opposite trends in each subgroup: among the majority of the participants (74%, the levels of cynicism and dedication were stable and inversely related, while among one-third their levels simultaneously changed in the reverse direction. The most successful progress in personal work goals was found in the groups described by the identification continuum, i.e., in the groups of “Low stable cynicism – high stable dedication” and “Decreasing cynicism – increasing dedication”.

  8. Propuesta de mejora continua para la mesa de ayuda de la UGPP

    OpenAIRE

    2012-01-01

    El propósito del Mejoramiento Continuo del Servicio (MCS) es alinear y realinear continuamente los servicios de TI con las necesidades cambiantes del negocio por medio de la identificación e implementación de mejoras a los servicios de TI que respaldan los Procesos del Negocio. Para esta Organización en particular se cumplieron tres etapas: La primera un diagnóstico del estado actual de proceso de mesa de ayuda, de la herramienta de apoyo a la gestión de incidentes y al equipo humano de sopo...

  9. Variational formulation for dissipative continua and an incremental J-integral

    Science.gov (United States)

    Rahaman, Md. Masiur; Dhas, Bensingh; Roy, D.; Reddy, J. N.

    2018-01-01

    Our aim is to rationally formulate a proper variational principle for dissipative (viscoplastic) solids in the presence of inertia forces. As a first step, a consistent linearization of the governing nonlinear partial differential equations (PDEs) is carried out. An additional set of complementary (adjoint) equations is then formed to recover an underlying variational structure for the augmented system of linearized balance laws. This makes it possible to introduce an incremental Lagrangian such that the linearized PDEs, including the complementary equations, become the Euler-Lagrange equations. Continuous groups of symmetries of the linearized PDEs are computed and an analysis is undertaken to identify the variational groups of symmetries of the linearized dissipative system. Application of Noether's theorem leads to the conservation laws (conserved currents) of motion corresponding to the variational symmetries. As a specific outcome, we exploit translational symmetries of the functional in the material space and recover, via Noether's theorem, an incremental J-integral for viscoplastic solids in the presence of inertia forces. Numerical demonstrations are provided through a two-dimensional plane strain numerical simulation of a compact tension specimen of annealed mild steel under dynamic loading.

  10. La continua fragmentación político electoral costarricense, elecciones 2014

    OpenAIRE

    Camino, Juan Francisco

    2014-01-01

    [ES] El 2 de febrero del 2014 se llevó a cabo la décimo séptima elección consecutiva en Costa Rica, donde se eligieron Presidente, Vicepresidentes y 57 Diputados a la Asamblea Legislativa para el período 2014-2018 (Decreto de Convocatoria a Elecciones Generales No. 11; 2013). En esta elección, de acuerdo con los resultados emitidos por el Tribunal Supremo de Elecciones para las elecciones presidenciales, el ganador fue el Partido Acción Ciudadana (PAC), con el 30,64% seguido del gobernante Pa...

  11. Encontrando al Kaizen : un análisis teórico de la mejora continua

    Directory of Open Access Journals (Sweden)

    Manuel Francisco Suárez Barraza

    2008-12-01

    Full Text Available Desde que Masaaki lmai acuño el término de Kaizen a mediados de los años ochenta, este se ha visto como un elemento clave para la competitividad de las empresas japonesas. No obstante, y a pesar de que el Kaizen ha sido definido por el autor que condujo a la luz el término, todavía sigue existiendo en la literatura sobre el tema cierta ambigüedad e inconsistencia. Además, existe una clara necesidad de desarrollar esta teoría en el campo de la dirección de operaciones.El propósito de este trabajo es analizar el Kaizen en la literatura académica y práctica con el fin de mejorar, explorar y hacer una contribución a su potencial perfil teórico. Se realizó una revisión de la literatura usando Kaizen como término de búsqueda en varias bases de datos: Proquest, Business Source Elite, Business Source Premier, Emerald, Science Direct and Google Scholar. También se consultaron libros escritos tanto por académicos como por los que lo practican. La literatura concerniente al Kaizen fue metodológicamente analizada y clasificada. Los hallazgos del estudio indican que el Kaizen es presentado bajo tres perspectivas o esferas, que incluyen una serie de principios y técnicas. Comparando los tres puntos de vista, emergieron un conjunto de principios y/o piedras angulares.Since Masaaki 'mai coined the term Kaizen in the mid eighties it has been regarded as a key element in the competitiveness of Japanese companies. However, even though Kaizen was defined by the author who created the term, writings by scholars and practitioners in the field exhibit a certain degree of ambiguity and inconsistency. Finally, there is a clear need to develop this theory in the field of operations management. Kaizen in the academic and practitioner literature in order to better understand it and further explore and contribute to its potential theoretical profile. A literature review was carried out using Kaizen as a search term. Various databases were used for this purpose: Proquest, Business Source Elite, Business Source Premier, Emerald, Science Direct and Google Scholar. Books written by both scholars and by practitioners on the subject were also consulted. The literature concerning Kaizen was methodically analyzed and categorized. The findings of the study indicate that Kaizen is presently displayed under three perspectives or spheres, which include a series of principies and techniques. By comparing the three viewpoints, a set of guiding principies and/or cornerstones for Kaizen have also emerged.

  12. Mental illness and mental health: The two continua model across the lifespan

    NARCIS (Netherlands)

    Westerhof, Gerben Johan; Keyes, Cory L.M.

    2010-01-01

    Mental health has long been defined as the absence of psychopathologies, such as depression and anxiety. The absence of mental illness, however, is a minimal outcome from a psychological perspective on lifespan development. This article therefore focuses on mental illness as well as on three core

  13. Classification of frequency response areas in the inferior colliculus reveals continua not discrete classes

    OpenAIRE

    Palmer, Alan R; Shackleton, Trevor M; Sumner, Christian J; Zobay, Oliver; Rees, Adrian

    2013-01-01

    A differential response to sound frequency is a fundamental property of auditory neurons. Frequency analysis in the cochlea gives rise to V-shaped tuning functions in auditory nerve fibres, but by the level of the inferior colliculus (IC), the midbrain nucleus of the auditory pathway, neuronal receptive fields display diverse shapes that reflect the interplay of excitation and inhibition. The origin and nature of these frequency receptive field types is still open to question. One proposed hy...

  14. An astrophysics data program investigation of a synoptic study of quasar continua

    Science.gov (United States)

    Elvis, Martin

    1991-01-01

    A summary of the program is presented. The major product of the program, an atlas of quasar energy distributions, is presented in the appendices along with papers written as a result of this research. The topics covered in the papers include: (1) accurate galactic N(sub h) values toward quasars and active galactic nuclei (AGN); (2) weak bump quasars; (3) millimeter measurements of hard x ray selected active galaxies- implications for the nature of the continuous spectrum; (3) persistence and change in the soft x ray spectrum of the quasar PG1211+143; (4) the soft x ray excess in einstein quasar spectra; and (5) EXOSAT x ray spectra of quasars.

  15. Topics in acoustics, non destructive testing, and thermo-mechanics of continua

    International Nuclear Information System (INIS)

    Suarez Antola, R.

    2001-03-01

    A small scale physical model of a granular porous medium was studied .Osmosis, filtration and fracture were considered, both experimentally and mathematically.Longitudinal ultrasonic pulse velocity was measured in slender timber and concrete bodies in order to characterized the geometric dispersion effects.A mathematical model is developed to described geometric dispersion in reinforced concrete.A sequential method for non destructive testing of structures by mechanicals vibrations is proposed and theoretically considered.Some simple examples are fully developed from a theoretical stand point

  16. Geophysical models of heat and fluid flow in damageable poro-elastic continua

    Czech Academy of Sciences Publication Activity Database

    Roubíček, Tomáš

    2017-01-01

    Roč. 29, č. 2 (2017), s. 625-646 ISSN 0935-1175 R&D Projects: GA ČR(CZ) GA16-03823S; GA ČR GA14-15264S Institutional support: RVO:61388998 Keywords : poro-elastic rocks * damage * biot model Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 2.529, year: 2016 https://link.springer.com/article/10.1007/s00161-016-0547-5

  17. Distributed material density and anisotropy for optimized eigenfrequency of 2D continua

    DEFF Research Database (Denmark)

    Pedersen, Pauli; Pedersen, Niels Leergaard

    2015-01-01

    A practical approach to optimize a continuum/structural eigenfrequency is presented, including design of the distribution of material anisotropy. This is often termed free material optimization (FMO). An important aspect is the separation of the overall material distribution from the local design...... with respect to material density and from this values of the element OC. Each factor of this expression has a physical interpretation. Stated alternatively, the optimization problem of material distribution is converted into a problem of determining a design of uniform OC values. The constitutive matrices...... are described by non-dimensional matrices with unity norms of trace and Frobenius, and thus this part of the optimized design has no influence on the mass distribution. Gradients of eigenfrequency with respect to the components of these non-dimensional constitutive matrices are therefore simplified...

  18. El docente del nivel inicial: retos para la formación profesional y continua

    Directory of Open Access Journals (Sweden)

    Vivian Lissett Ospina Tascón

    2016-08-01

    Full Text Available En este artículo teórico se realiza un recorrido general por la situación docente en América Latina, específicamente por la situación de educadores del nivel inicial. A partir de esto, se establece una relación entre algunos de los conflictos de los educadores de primera infancia y la configuración histórica de la forma en que fueron educados en tanto adultos para pensar y relacionarse con los niños y niñas. Se presentan argumentos epistemológicos que invitan a formas alternativas de construcción de conocimiento sobre las infancias en los contextos contemporáneos. También se plantean interrogantes en torno a las propuestas de formación docente y se sugieren algunas nuevas, a propósito del educador y la posición subjetiva desde la cual se enfrenta con la experiencia infantil. AbstractThis theoretical article carries through a general view about the teacher situationin Latin America, especifically the early`childhood from which it is pretended to establish a relation between some of the conflicts earlychildhood educators experience and the historical configuration under which they were educated as adults able to think and related to infancy. Epistemological arguments are presented in order to consider alternative ways of constructing knowledge about infancies in contemporary contexts. Some queries are presentedabout teacher´s education proposals and some others are also suggested, concerning the educator and his/her subjective position from which he/ she deals with children experience.

  19. Dynamics of continua and particles from general covariance of Newtonian gravitation theory

    International Nuclear Information System (INIS)

    Duval, C.; Kunzle, H.P.

    1976-07-01

    The principle of general covariance, which states that the total action functional in General Relativity is independent of coordinate transformations, is shown to be also applicable to the four-dimensional geometric theory of Newtonian gravitation. It leads to the correct conservation (or balance) equations of continuum mechanics as well as the equations of motion of test particles in a gravitational field. The degeneracy of the ''metric'' of Newtonian space-time forces to introduce a ''gauge field'' which fixes the connection and leads to a conserved current, the mass flow. The particle equations are also derived from an invariant Hamiltonian structure on the extended Galilei group and a minimal interaction principle. One not only finds the same equations of motion but even the same gauge fields

  20. CHARACTERISTIC SIZE OF FLARE KERNELS IN THE VISIBLE AND NEAR-INFRARED CONTINUA

    International Nuclear Information System (INIS)

    Xu, Yan; Jing, Ju; Wang, Haimin; Cao, Wenda

    2012-01-01

    In this Letter, we present a new approach to estimate the formation height of visible and near-infrared emission of an X10 flare. The sizes of flare emission cores in three wavelengths are accurately measured during the peak of the flare. The source size is the largest in the G band at 4308 Å and shrinks toward longer wavelengths, namely the green continuum at 5200 Å and NIR at 15600 Å, where the emission is believed to originate from the deeper atmosphere. This size-wavelength variation is likely explained by the direct heating model as electrons need to move along converging field lines from the corona to the photosphere. Therefore, one can observe the smallest source, which in our case is 0.''65 ± 0.''02 in the bottom layer (represented by NIR), and observe relatively larger kernels in upper layers of 1.''03 ± 0.''14 and 1.''96 ± 0.''27, using the green continuum and G band, respectively. We then compare the source sizes with a simple magnetic geometry to derive the formation height of the white-light sources and magnetic pressure in different layers inside the flare loop.

  1. CHARACTERISTIC SIZE OF FLARE KERNELS IN THE VISIBLE AND NEAR-INFRARED CONTINUA

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Yan; Jing, Ju; Wang, Haimin [Space Weather Research Lab, Center for Solar-Terrestrial Research, New Jersey Institute of Technology, 323 Martin Luther King Blvd, Newark, NJ 07102-1982 (United States); Cao, Wenda, E-mail: yx2@njit.edu [Big Bear Solar Observatory, Center for Solar-Terrestrial Research, New Jersey Institute of Technology, 323 Martin Luther King Blvd, Newark, NJ 07102-1982 (United States)

    2012-05-01

    In this Letter, we present a new approach to estimate the formation height of visible and near-infrared emission of an X10 flare. The sizes of flare emission cores in three wavelengths are accurately measured during the peak of the flare. The source size is the largest in the G band at 4308 A and shrinks toward longer wavelengths, namely the green continuum at 5200 A and NIR at 15600 A, where the emission is believed to originate from the deeper atmosphere. This size-wavelength variation is likely explained by the direct heating model as electrons need to move along converging field lines from the corona to the photosphere. Therefore, one can observe the smallest source, which in our case is 0.''65 {+-} 0.''02 in the bottom layer (represented by NIR), and observe relatively larger kernels in upper layers of 1.''03 {+-} 0.''14 and 1.''96 {+-} 0.''27, using the green continuum and G band, respectively. We then compare the source sizes with a simple magnetic geometry to derive the formation height of the white-light sources and magnetic pressure in different layers inside the flare loop.

  2. Modeling of thin-walled structures interacting with acoustic media as constrained two-dimensional continua

    Science.gov (United States)

    Rabinskiy, L. N.; Zhavoronok, S. I.

    2018-04-01

    The transient interaction of acoustic media and elastic shells is considered on the basis of the transition function approach. The three-dimensional hyperbolic initial boundary-value problem is reduced to a two-dimensional problem of shell theory with integral operators approximating the acoustic medium effect on the shell dynamics. The kernels of these integral operators are determined by the elementary solution of the problem of acoustic waves diffraction at a rigid obstacle with the same boundary shape as the wetted shell surface. The closed-form elementary solution for arbitrary convex obstacles can be obtained at the initial interaction stages on the background of the so-called “thin layer hypothesis”. Thus, the shell–wave interaction model defined by integro-differential dynamic equations with analytically determined kernels of integral operators becomes hence two-dimensional but nonlocal in time. On the other hand, the initial interaction stage results in localized dynamic loadings and consequently in complex strain and stress states that require higher-order shell theories. Here the modified theory of I.N.Vekua–A.A.Amosov-type is formulated in terms of analytical continuum dynamics. The shell model is constructed on a two-dimensional manifold within a set of field variables, Lagrangian density, and constraint equations following from the boundary conditions “shifted” from the shell faces to its base surface. Such an approach allows one to construct consistent low-order shell models within a unified formal hierarchy. The equations of the N th-order shell theory are singularly perturbed and contain second-order partial derivatives with respect to time and surface coordinates whereas the numerical integration of systems of first-order equations is more efficient. Such systems can be obtained as Hamilton–de Donder–Weyl-type equations for the Lagrangian dynamical system. The Hamiltonian formulation of the elementary N th-order shell theory is here briefly described.

  3. Interação museu-escola : a importância dos programas de formação continuada de professores em municípios afastados dos centros urbanos Museum-school interactions: the importance of continuing education programs for teachers in municipalities away from urban centres Interaction musée-école : l’importance des programmes de formation continue des enseignants dans les municipalités éloignées des centres urbains Interacción museo-escuela : la importancia de los programas de formación continua de profesores en localidades alejadas de los centros urbanos

    Directory of Open Access Journals (Sweden)

    Grazielle Rodrigues Pereira

    2011-09-01

    de una serie de conceptos equivocados respecto a la ciencia, los centros y museos de ciencias surgen con propuestas para romper con el paradigma de la ciencia accesible solo a una pequeña parte de la población. Estos espacios desarrollan actividades con fines de inclusión social en función de su carácter educativo, y así invierten, entre otras acciones, en estrategias para la actualización de los profesionales de la educación. La mayor parte de estos espacios se concentran aún en los grandes centros urbanos, dificultando la participación de las clases sociales menos favorecidas. Este trabajo presenta un programa piloto de formación continua de profesores desarrollado por el Espaço Ciência InterAtiva del IFRJ (Instituto Federal de Río de Janeiro, un museo de ciencias ubicado en una región periférica de Rio de Janeiro, demostrando así que una exposición científica puede contribuir a la inserción de los docentes en los espacios de educación no formal, así como a la formación continua de los mismos.Em virtude de uma série de concepções equivocadas a respeito da ciência, os centros e museus de ciências surgem com propostas de romper com o paradigma da ciência voltada para uma pequena parcela da população. Esses espaços desenvolvem atividades com vistas à inclusão social em função do seu caráter educacional, e com isso investem, entre outras ações, em estratégias de atualização do profissional da educação. Todavia, a maior parte desses espaços concentra-se nos grandes centros urbanos, dificultando a participação das camadas menos favorecidas da sociedade. Dessa forma, o presente trabalho apresenta o relato de um programa piloto de formação continuada de professores, desenvolvido pelo Espaço Ciência InterAtiva do IFRJ, um museu de ciências localizado em uma região periférica do Rio de Janeiro, demonstrando assim que uma exposição científica pode contribuir para a inserção dos docentes nesses espaço de educação n

  4. [Oral loading dose of phenytoin in the treatment of serial seizures, prevention of seizure recurrence and rapid drug substitution].

    Science.gov (United States)

    Sokić, D; Janković, S M

    1994-01-01

    Over a period of nine months twenty-five epileptic patients were treated with the oral loading dose of phenytoin. The dose ranged from 12 to 23 mg/kg body weight during 1 to 12 hours. In 20 patients with serial seizures or intolerance to other antiepileptic drugs this treatment was effective. Seizures also stopped in 2 of 4 patients with serial partial motor seizures. These 2 patients required both higher loading dose and faster rate of administration than the other patients. A patient with epilepsia partialis continua failed to respond to the treatment. Patients that received phenytoin through the naso-gastric tube, in respect to oral administration, required higher doses to obtain therapeutic plasma levels of phenytoin. One patient had mild nausea, 3 mild dizziness, and 1 tinitus on the first day of the treatment. There was no correlation between a given dose and the achieved phenytoin plasma levels. In our opinion the therapy with oral loading dose of phenytoin is highly effective in the treatment of serial generalized seizures and rapid antiepileptic drug substitution, and partially effective in the prevention of partial motor seizures. It produces only mild and transient side-effects.

  5. Putaminal involvement in Rasmussen encephalitis

    Energy Technology Data Exchange (ETDEWEB)

    Rajesh, Bhagavatheeswaran; Ashalatha, Radhakrishnan [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Neurology, Trivandrum, Kerala (India); Kesavadas, Chandrasekharan; Thomas, Bejoy [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Imaging Sciences and Interventional Radiology, Trivandrum, Kerala (India)

    2006-08-15

    Rasmussen encephalitis (RE) is a rare devastating disease of childhood causing progressive neurological deficits and intractable seizures, typically affecting one hemisphere. Characteristic MRI features include progressive unihemispheric focal cortical atrophy and grey- or white-matter high-signal changes and basal ganglion involvement, particularly of the caudate nucleus. To analyse the pattern of involvement of different brain structures in a series of patients with RE and to attempt clinical correlation. We reviewed the medical records and neuroimaging data of 12 patients diagnosed with RE satisfying the European Consensus Statement diagnostic criteria. The disease manifested as seizures in all patients and was refractory; epilepsia partialis continua was a notable feature (nine patients). Hemiparesis of varying grades was noted in all but one patient; none had extrapyramidal signs. Neuroimaging showed cortical involvement in the insular/periinsular regions in 11 patients. Caudate atrophy was noted in ten patients. Putaminal atrophy was seen in nine patients, six of whom had additional hyperintense signal changes. Our study highlights frequent putaminal atrophy and signal changes in RE, which suggests a more extensive basal ganglion involvement than emphasized previously. Recognition of putaminal changes may be a useful additional tool in the radiological diagnosis of RE. (orig.)

  6. Serial MRI and MRS studies with unusual findings in Rasmussen's encephalitis

    International Nuclear Information System (INIS)

    Tuerkdogan-Soezueer, D.; Oezek, M.M.; Pamir, M.N.; Sav, A.; Dincer, A.

    2000-01-01

    Rasmussen's syndrome is characterized by intractable seizures and progressive neuropsychiatric deterioration secondary to unilateral cortical inflammation and tissue destruction. Diagnosis of Rasmussen's syndrome in the early phase depends mainly on the clinical features. Neuroimaging and histopathologic examinations may not be specific during this period. We report a case of Rasmussen's syndrome followed by serial MRI and magnetic resonance spectroscopy (MRS) studies over a 3- to 16-month period. A healthy 6-year-old boy presented with focal motor seizures. An MRI study demonstrated prominent enlargement and T2 hyperintensity of the left mesial temporal lobe and perisylvian region. This early finding evolved to volume loss and later progressive atrophy of the ipsilateral hemisphere when epilepsia partialis continua occurred. Being aware of those early MRI features in a patient with increasing frequency of focal motor seizures should suggest Rasmussen's syndrome. In addition, we found prominently increased myoinositol concentration in atrophic cortex which might reflect increased gliosis in the late period of the disease. (orig.)

  7. Focal neuronal loss, reversible subcortical focal T2 hypointensity in seizures with a nonketotic hyperglycemic hyperosmolar state

    International Nuclear Information System (INIS)

    Raghavendra, S.; Ashalatha, R.; Thomas, Sanjeev V.; Kesavadas, C.

    2007-01-01

    Neuroimaging in seizures associated with nonketotic hyperglycemia (NKH) is considered normal. We report magnetic resonance imaging (MRI) abnormalities in four patients with NKH and seizures. We prospectively evaluated clinical and radiological abnormalities in four patients with NKH during the period March 2004 to December 2005. All patients presented with seizures, either simple or complex partial seizures or epilepsia partialis continua. Two of them had transient hemianopia. MRI showed subcortical T2 hypointensity in the occipital white matter and in or around the central sulcus (two patients each), T2 hyperintensity of the overlying cortex (two patients), focal overlying cortical enhancement (three patients) and bilateral striatal hyperintensity (one patient). Diffusion-weighted imaging (DWI) performed in three patients showed restricted diffusion. The ictal semiology and electroencephalographic (EEG) findings correlated with the MRI abnormalities. On clinical recovery, the subcortical T2 hypointensity and striatal hyperintensity reversed in all patients. The initial cortical change evolved to FLAIR hyperintensity suggestive of focal cortical gliosis. The radiological differential diagnosis considered initially included encephalitis, malignancy and hemorrhagic infarct rendering a diagnostic dilemma. We identified subcortical T2 hypointensity rather than hyperintensity as a characteristic feature of seizures associated with NKH. Only very few similar reports exist in literature. Reversible bilateral striatal T2 hyperintensity in NKH has not been reported to the best of our knowledge. (orig.)

  8. Focal neuronal loss, reversible subcortical focal T2 hypointensity in seizures with a nonketotic hyperglycemic hyperosmolar state

    Energy Technology Data Exchange (ETDEWEB)

    Raghavendra, S.; Ashalatha, R.; Thomas, Sanjeev V. [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Neurology, Trivandrum, Kerala (India); Kesavadas, C. [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Imaging Sciences and Interventional Radiology, Trivandrum (India)

    2007-04-15

    Neuroimaging in seizures associated with nonketotic hyperglycemia (NKH) is considered normal. We report magnetic resonance imaging (MRI) abnormalities in four patients with NKH and seizures. We prospectively evaluated clinical and radiological abnormalities in four patients with NKH during the period March 2004 to December 2005. All patients presented with seizures, either simple or complex partial seizures or epilepsia partialis continua. Two of them had transient hemianopia. MRI showed subcortical T2 hypointensity in the occipital white matter and in or around the central sulcus (two patients each), T2 hyperintensity of the overlying cortex (two patients), focal overlying cortical enhancement (three patients) and bilateral striatal hyperintensity (one patient). Diffusion-weighted imaging (DWI) performed in three patients showed restricted diffusion. The ictal semiology and electroencephalographic (EEG) findings correlated with the MRI abnormalities. On clinical recovery, the subcortical T2 hypointensity and striatal hyperintensity reversed in all patients. The initial cortical change evolved to FLAIR hyperintensity suggestive of focal cortical gliosis. The radiological differential diagnosis considered initially included encephalitis, malignancy and hemorrhagic infarct rendering a diagnostic dilemma. We identified subcortical T2 hypointensity rather than hyperintensity as a characteristic feature of seizures associated with NKH. Only very few similar reports exist in literature. Reversible bilateral striatal T2 hyperintensity in NKH has not been reported to the best of our knowledge. (orig.)

  9. Putaminal involvement in Rasmussen encephalitis

    International Nuclear Information System (INIS)

    Rajesh, Bhagavatheeswaran; Ashalatha, Radhakrishnan; Kesavadas, Chandrasekharan; Thomas, Bejoy

    2006-01-01

    Rasmussen encephalitis (RE) is a rare devastating disease of childhood causing progressive neurological deficits and intractable seizures, typically affecting one hemisphere. Characteristic MRI features include progressive unihemispheric focal cortical atrophy and grey- or white-matter high-signal changes and basal ganglion involvement, particularly of the caudate nucleus. To analyse the pattern of involvement of different brain structures in a series of patients with RE and to attempt clinical correlation. We reviewed the medical records and neuroimaging data of 12 patients diagnosed with RE satisfying the European Consensus Statement diagnostic criteria. The disease manifested as seizures in all patients and was refractory; epilepsia partialis continua was a notable feature (nine patients). Hemiparesis of varying grades was noted in all but one patient; none had extrapyramidal signs. Neuroimaging showed cortical involvement in the insular/periinsular regions in 11 patients. Caudate atrophy was noted in ten patients. Putaminal atrophy was seen in nine patients, six of whom had additional hyperintense signal changes. Our study highlights frequent putaminal atrophy and signal changes in RE, which suggests a more extensive basal ganglion involvement than emphasized previously. Recognition of putaminal changes may be a useful additional tool in the radiological diagnosis of RE. (orig.)

  10. Brain SPECT in the pre-surgical evaluation of epileptic patients

    International Nuclear Information System (INIS)

    Buchpiguel, C.A.; Cukiert, A.; Hironaka, F.H.; Cerri, G.G.; Magalhaes, A.E.A.; Marino Junior, R.

    1992-01-01

    Fifteen adult epileptic patients were studied pre-operatively using a rotational scintillation camera interfaced to a dedicated computer. The tomographic images were obtained 15 minutes after intravenous injection of 99 m Tc-HMPAO. All had MRI scanning and intensive EEG monitoring which generally included seizure recording. Five patients had progressive lesions (3 meningiomas, 2 astrocytomas). In 10 patients, neuroradiological studies did not show the presence of progressive lesions (2 normal scans and 8 cases with inactive lesions). Two patients with meningioma showed hypoperfusion at the lesion site while the third patient had a marked hypoperfusion which might correlate with the clinical diagnosis of epilepsia partialis continua. In the astrocytoma patients SPECT scans showed hypoperfusion at the lesion site. Data obtained from the 10 patients without progressive CNS lesions showed: in 4, SPECT findings correlated well with the anatomical findings; in 5 instances, SPECT was able to disclose additional functional deficits; in one case, there was no SPECT correlate of a discrete anatomical lesion. In 5 of these cases with no progressive lesions (n=10) SPECT findings were useful as a complementary tool in determining the clinical or surgical management of these patients. Despite the small number and heterogeneity of the present sample, SPECT seems to be an useful tool as part of the clinical workup of epileptic who are candidates for epilepsy surgery. (author)

  11. Serial MRI and MRS studies with unusual findings in Rasmussen's encephalitis

    Energy Technology Data Exchange (ETDEWEB)

    Tuerkdogan-Soezueer, D. [Department of Pediatric Neurology, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Oezek, M.M.; Pamir, M.N. [Department of Neurosurgery, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Sav, A. [Department of Pathology, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Dincer, A. [Radyomar MR Center, Istanbul (Turkey)

    2000-06-01

    Rasmussen's syndrome is characterized by intractable seizures and progressive neuropsychiatric deterioration secondary to unilateral cortical inflammation and tissue destruction. Diagnosis of Rasmussen's syndrome in the early phase depends mainly on the clinical features. Neuroimaging and histopathologic examinations may not be specific during this period. We report a case of Rasmussen's syndrome followed by serial MRI and magnetic resonance spectroscopy (MRS) studies over a 3- to 16-month period. A healthy 6-year-old boy presented with focal motor seizures. An MRI study demonstrated prominent enlargement and T2 hyperintensity of the left mesial temporal lobe and perisylvian region. This early finding evolved to volume loss and later progressive atrophy of the ipsilateral hemisphere when epilepsia partialis continua occurred. Being aware of those early MRI features in a patient with increasing frequency of focal motor seizures should suggest Rasmussen's syndrome. In addition, we found prominently increased myoinositol concentration in atrophic cortex which might reflect increased gliosis in the late period of the disease. (orig.)

  12. [NMDA-GluR Subunit Antibody-Positive Encephalitis: A Clinical Analysis of Five Cases].

    Science.gov (United States)

    Kaneko, Chikako; Shakespear, Norshalena; Tuchiya, Mario; Kubo, Jin; Yamamoto, Teiji; Katayama, Soichi; Takahashi, Yukitoshi

    2016-09-01

    Five consecutive cases of anti-NMDA-receptor encephalitis that we encountered were marked by a rapidly fluctuating level of consciousness associated with psychotic and delirious mental states. Opisthotonus, catatonia, and rhythmic and non-rhythmic involuntary movements of the mouth and jaw were also characteristic features of these particular cases. Serious and potentially fatal problems included epilepsia partialis continua, partial and generalized seizures, and respiratory depression, resembling the symptoms of encephalitis lethargica. An epidemic of encephalitis lethargica, also known of Economo encephalitis, occurred around 1917. Magnetic resonance imaging revealed edema of the neocortex in two cases and electroencephalography showed polymorphic and monomorphic delta slowing in the acute stage, although electroencephalographic seizure activity were not apparent. Routine cerebrospinal fluid analyses revealed lymphocyte-dominant pleocytosis in three cases, but antibodies against the NMDA-GluR subunit, GluN2B N-terminal, were at a high level in the fluid. All patients recovered without apparent sequelae. Two patients found to have ovarian teratoma underwent surgery for tumor removal. Treatments included pulse intravenous methylprednisolone, high-dose immunoglobulin, and plasma exchange together with seizure control and respiratory support. However, rituximab and or cyclophosphamide pulse therapy should also be considered for intractable cases, as indicated by recent reports. (Received February 16, 2016; Accepted May 2, 2016; Published September 1, 2016).

  13. Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Rasmussen-like Syndrome: An Association?

    Science.gov (United States)

    Gurcharran, Kevin; Karkare, Shefali

    2017-01-01

    N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune-mediated condition that has a broad spectrum of manifestations, including seizures, coma, psychosis, and focal neurological deficits. Although usually a diffuse process, unihemispheric involvement mimicking early stages of Rasmussen encephalitis can occur. Rasmussen's encephalitis is a unique syndrome characterized by progressive hemiplegia, drug-resistant focal epilepsy, cognitive decline, and hemispheric brain atrophy contralateral to the hemiplegia. We describe a two-year-old girl with progressive right weakness and epilepsia partialis continua, concerning for early Rasmussen's encephalitis, who tested positive for anti-NMDA receptor antibodies. She experienced complete clinical recovery after immunotherapy. Anti-NMDA receptor antibodies were absent at three weeks and again at one year after the first treatment of intravenous immunoglobulin. There are few reports of Rasmussen-like encephalitis in individuals with anti-NMDA receptor antibody positivity. Thus the clinical significance of this association is yet to be determined. In addition, several other antibodies have been documented in individuals with Rasmussen encephalitis. The lack of a consistently reported antibody in Rasmussen encephalitis patients and the temporary nature of the anti-NMDA receptor antibody in our patient raise the following question: Is the presence of anti-NMDA receptor antibodies the cause of the symptoms or secondary to the pathogenic process? Copyright © 2016 Elsevier Inc. All rights reserved.

  14. O desenvolvimento de um modelo de assistência continua ao parto Desarrollo de un modelo de asistencia continua en el parto Development of a delivery continued care model

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Silveira Lambert

    2010-07-01

    Full Text Available Objetivo. Descrever as experiências das enfermeiras obstétricas relacionadas com o desenvolvimento de um modelo de assistência ao parto. Metodologia. investigação do tipo estudo de caso. Analisaramse as declarações de quatro enfermeiras obstétricas, que desenvolveram o modelo de assistência ao parto proposto pelo Hospital Universitário da Universidade de São Paulo. A informação obtida se analisou de modo indutivo e interpretativo. Resultados. das narrativas surgiram quatro categorias descritivas: a a convivência com o sentimento de ambivalência, b o trabalho com facilidades e dificuldades com a adoção do novo modelo, c as mudanças no conceito da assistência ao parto, e d os benefícios proporcionados pelo modelo. As enfermeiras reconhecem a viabilidade do modelo, mas sua implementação definitiva na instituição depende das mudanças nas diretrizes filosóficas e gerenciais relacionadas com a assistência ao parto e do compromisso dos profissionais. Conclusão. Reconheceramse os diversos aspectos envolvidos na implementação do modelo de atendimento no parto.Objetivo. Describir las experiencias de las enfermeras obstétricas relacionadas con el desarrollo de un modelo de asistencia al parto. Metodología. Investigación del tipo estudio de caso. Se analizaron las declaraciones de cuatro enfermeras obstétricas, que desarrollaron el modelo de asistencia al parto propuesto por el Hospital Universitario de la Universidad de São Paulo. La información obtenida se analizó de modo inductivo e interpretativo. Resultados. De las narrativas surgieron cuatro categorías descriptivas: a la convivencia con el sentimiento de ambivalencia, b el trabajo con facilidades y dificultades con la adopción del nuevo modelo, c los cambios en el concepto de la asistencia al parto, y d los beneficios proporcionados por el modelo. Las enfermeras reconocen la viabilidad del modelo, pero su implementación definitiva en la institución depende de los cambios en las directrices filosóficas y gerenciales relacionadas con la asistencia al parto y del compromiso de los profesionales. Conclusión. Se reconocieron los diversos aspectos involucrados en la implementación del modelo de atención en el parto.Objective. To describe the obstetric nurses' experiences related with the development of a delivery care model. Methodology. Case study type research. Four obstetric nurses who developed the delivery care model proposed by the Sao Paulo university testimonies were analyzed. The obtained information was analyzed using an inductive interpretative way. Results. Four descriptive categories came up from the testimonies: a Coping with ambivalence feelings, b Work with ease and difficulties with the new model adoption, c the delivery concept changes and d the nurses recognized the model viability, but its implementation depends in the philosophical and management guidelines related with delivery care and professionals' commitment. Conclusion. The diverse aspects involved were recognized in the implementation of the delivery model.

  15. Placing prairie pothole wetlands along spatial and temporal continua to improve integration of wetland function in ecological investigations

    Science.gov (United States)

    Euliss, Ned H.; Mushet, David M.; Newton, Wesley E.; Otto, Clint R.V.; Nelson, Richard D.; LaBaugh, James W.; Scherff, Eric J.; Rosenberry, Donald O.

    2014-01-01

    We evaluated the efficacy of using chemical characteristics to rank wetland relation to surface and groundwater along a hydrologic continuum ranging from groundwater recharge to groundwater discharge. We used 27 years (1974–2002) of water chemistry data from 15 prairie pothole wetlands and known hydrologic connections of these wetlands to groundwater to evaluate spatial and temporal patterns in chemical characteristics that correspond to the unique ecosystem functions each wetland performed. Due to the mineral content and the low permeability rate of glacial till and soils, salinity of wetland waters increased along a continuum of wetland relation to groundwater recharge, flow-through or discharge. Mean inter-annual specific conductance (a proxy for salinity) increased along this continuum from wetlands that recharge groundwater being fresh to wetlands that receive groundwater discharge being the most saline, and wetlands that both recharge and discharge to groundwater (i.e., groundwater flow-through wetlands) being of intermediate salinity. The primary axis from a principal component analysis revealed that specific conductance (and major ions affecting conductance) explained 71% of the variation in wetland chemistry over the 27 years of this investigation. We found that long-term averages from this axis were useful to identify a wetland’s long-term relation to surface and groundwater. Yearly or seasonal measurements of specific conductance can be less definitive because of highly dynamic inter- and intra-annual climate cycles that affect water volumes and the interaction of groundwater and geologic materials, and thereby influence the chemical composition of wetland waters. The influence of wetland relation to surface and groundwater on water chemistry has application in many scientific disciplines and is especially needed to improve ecological understanding in wetland investigations. We suggest ways that monitoring in situ wetland conditions could be linked with evolving remote sensing technology to improve our ability to better inform decisions affecting wetland sustainability and provide periodic inventories of wetland ecosystem services to document temporal trends in wetland function and how they respond to contemporary land-use change.

  16. ZÚÑIGA: la sencillez de la vivienda continua elevada a rango de Zona Típica

    Directory of Open Access Journals (Sweden)

    Felipe Gallardo Gastelo

    2005-01-01

    Full Text Available Los atributos arquitectónicos y ambientales de la pequeña localidad de Zúñiga, localizada en la comuna de San Vicente de Tagua Tagua, Sexta Región, han sido reconocidos gracias a la reciente declaratoria de Zona Típica. Adicionalmente, se le ha concedido el Premio Nacional de Conservación Nacional en el rubro Agrupación Gremial, premiando el amor y la devoción que la comunidad ha demostrado por su escenario cotidiano. Una calle marginada de viviendas características del valle central, cuyos propietarios se han comprometido a mantenerla en buen estado de conservación. Para ello han contribuido a la elaboración de un instructivo, elaborado por el Instituto de Restauración Arquitectónica de la Facultad de Arquitectura y Urbanismo de la Universidad de Chile y validado por el Consejo de Monumentos Nacionales, mediante el cual el municipio podrá regular las intervenciones futuras.

  17. Energy dispersion of x-ray continua in the energy range 9kev to 19kev refraction on Si wafers

    International Nuclear Information System (INIS)

    Ebel, H.; Streli, C.; Pepponi, G.; Wobrauschek, P.

    2000-01-01

    Total reflection of x-rays in matter at given grazing incidence angle is characterized by the occurrence of an energy cut-off. Photons with energies greater than the cut-off energy penetrate into matter and are refracted according to a transition from the optically more dense to the optically less dense medium. Since the refractive index depends on photon energy, an energy dispersion of continuous x-radiation is observed. The present investigation is dedicated to the energy dispersion of continuous x-radiation (Mo, 45 kV) by Si wafers. Theory and experimental results are in excellent agreement. (author)

  18. Development of industry processes simulators. Part II (continuous casting); Desarrollo de simuladores para procesos industriales. Parte II (Colada continua)

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, A.; Mosqueda, A.; Sauce, V.; Morales, R.; Ramos, A.; Solario, G.

    2006-07-01

    The understanding of steel thermal behavior is very important in order to take care the quality of the products like billets and slabs due to these; this work shows the joint of a subroutine to simulate the heat transfer conditions during the continuous casting process to the model for simulating the process described by the present authors in a previous work; the result is the temperature profiles and surface temperature graphics of the steel, then they are compared with data carried out or real operating conditions. (Author). 15 refs.

  19. Uso de TIC`s en circuitos de corriente continua: propuesta didáctica y evaluación.

    OpenAIRE

    Enrique, Claudio Mario

    2015-01-01

    Este trabalho tem como objetivo descrever e analisar os resultados de uma proposta educacional baseadana utilização das Tecnologias de Informação e comunicação (TIC´s) em circuitos elétricos. Na experiência écomprovada experimentalmente a lei de Ohm, e a obtenção da resistência equivalente é deduzida para as disposiçõesem série e em paralelo. Em seguida, são analisados de forma descritiva as escritas dos relatórios do trabalho prático,com a intenção de vislumbrar se o a aprendizagem foi signi...

  20. E o cinema continua -: apontamentos sobre a presença do real em Através das Oliveiras

    Directory of Open Access Journals (Sweden)

    Paiva, Sílvia de

    2007-01-01

    Full Text Available Através das Oliveiras. . . Uma história de amor, um set de filmagens e um cineasta em busca dos vestígios do real numa região devastada por um terremoto. Entre documentário e ficção, para além das bordas da tela, imersos em longos planos e permeados por um clima de incerteza, presenciamos a obra do cineasta iraniano Abbas Kiarostami estabelecer um intenso diálogo com a dimensão mais comum e cotidiana do real. Through the Olive Trees … A history of love, a set of filmings and a director in search of the vestiges of the reality in a region destroyed by an earthquake. Between documentary and fiction, beyond the edges of the screen, immersed in long takes and involved by uncertainties, we witness the work of the director Abbas Kiarostami creating an intense dialogue with the daily and most common dimension of the reality.

  1. Observations of human factors as a continuous improvement tool; Las obervaciones de factores humanos como herramienta de mejora continua

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, P.

    2015-07-01

    Principles for Excellence in Human Performance should promote behaviors throughout an organization that support safety and reliable operation of the plant. Such behaviors must be clearly defined, communicated and reinforced by managers, on a continuous basis. To identify if workers behaviors are in compliance with those expected is paramount to have an observations program in place, which in one hand identifies deviations from expectations to correct them, and on the other promotes the desired behaviors through positive reinforcement. (Author)

  2. The program of continuous improvements in factory in Juzbado; El programa de mejora continua en la Fabrica de Juzbado

    Energy Technology Data Exchange (ETDEWEB)

    Prieto, M.

    2015-07-01

    This articles describes the historical development of the continuous improvement program at Juzbado Factory, since its beginning to nowadays. The evolution throughout the ideas of Total Quality, ISO, EFQM, Six Sigma, and so on, leading to the present situation in which all these tools and methodologies live together is shown. all this has led to a philosophy and business culture focused on safety, quality and continuous improvement. (Author)

  3. MODELADO CONCEPTUAL DE LA SUPERVISIÓN DE UN SISTEMA HOLÓNICO DE PRODUCCIÓN CONTINUA

    Directory of Open Access Journals (Sweden)

    CARLOS PARRA ORTEGA

    2012-06-01

    Full Text Available La arquitectura de automatización PROSA es una descripción orientada hacia objetos que implementan sistemas de producción. Un enfoque basadoen sistemas para eventos discretos, detección de eventos y la teoría de control supervisorio, representa el comportamiento de una unidad de producción controlada. Para obtener la descripción orientada a objetosde esta unidad, se aplicó modelado conceptual y se utilizó el Lenguaje unificado de modelado.

  4. La formación y las organizaciones. Los Acuerdos Nacionales de Formación Continua

    Directory of Open Access Journals (Sweden)

    ISABEL DE LA TORRE

    1997-01-01

    Full Text Available el articulo parte de una reflexion inicial sobre los conceptos de educacion, formacion y aprendizaje, considerandolos recursos fundamentales para hacer frente a las exigencias de adaptacion y cambio en la actual sociedad del conocimiento y de la informacion. una adaptacion imprescindible en las organizaciones, ya que sus estructuras cada vez requieren mayor flexibilidad y, en consecuencia, una adecuacion de los hombres y mujeres que las integran. la adaptacion es posible cuando las personas disponen de una educacion y formacion basica y continuada, que les permite interpretar los cambios, ofrecer respuestas creativas y participar en las propuestas de accion. hacer posible la formacion permanente es el resultado de la adopcion de una actuacion concreta. en la sociedad española se ha establecido un modelo de formacion continuada que tiene unas peculiaridades de especial interes. la adopcion de este modelo es fruto del acuerdo entre los principales representantes de los agentes sociales, materializado en la firma de un primer acuerdo en 1992 y de un segundo acuerdo en 1996.

  5. Programa de evaluación continua de riesgos para la aeronavegabilidad en la Fuerza Aérea Colombiana (CARE

    Directory of Open Access Journals (Sweden)

    Ana Isabel Aguilar González

    2010-01-01

    Igualmente, busca proponer la implementación de acciones efectivas que mitiguen su influencia negativa, mediante la optimización de los procesos de gestión organizacional empleados en el mantenimiento aeronáutico, esperando que se constituya en un aporte valioso para poder conocer la condición actual de la aeronavegabilidad y sus efectos en la seguridad operacional dentro de la Fuerza Aérea Colombiana.

  6. Empleo, desigualdad y globalización: una preocupación continua Employment, Inequality and Globalization: A Continuous Concern

    Directory of Open Access Journals (Sweden)

    Rolph van der Hoeven

    2010-12-01

    Full Text Available El presente artículo aborda el tema de la crisis económica mundial y su fuerte impacto sobre la población. Muestra la preocupación por los efectos de dicha crisis, principalmente en el incremento del desempleo, que genera mayores desigualdades sociales puesto que las personas se ven abocadas a trabajar de manera informal, hecho que va en contra de la estabilidad laboral y del desarrollo humano. A través de una mirada a la posición asumida por diversos autores que manejan el tema financiero, se encuentra que las políticas pùblicas surgidas de diferentes épocas no han sido una respuesta satisfactoria para equilibrar las desigualdades socioeconómicas dado que no ha sido posible lograr un crecimiento económico que redunde en una distribución del ingreso más equitativa, capaz de generar un verdadero desarrollo humano. Se contemplan algunas alternativas para promover el crecimiento del empleo, desde lo fiscal y lo monetario hasta lo industrial y lo comercial, al igual que se presentan algunas posiciones para enfrentar los efectos de la globalización.This article deals the issue of global economic crisis and its strong impact on the population. Shows concern for the effects of the crisis, mainly through increases in unemployment, which generates greater social inequality as people are forced to work informally, a fact that goes against labor stability and human development. Through a look at the position assumed by several authors who handle financial issues, is that public policies arising from different periods have not been a satisfactory answer to balance socioeconomic inequalities because it has not been possible to achieve economic growth result in a more equitable income distribution, capable of generate a true human development. Alternatives are contemplated to promote employment growth, from fiscal and monetary toward the industrial and commercial, as are some positions to face the effects of globalization.

  7. Mejora Continua y Benchmarking Interno Aplicados a la Gestión de Costes: Experiencia en un Grupo Multinacional

    Directory of Open Access Journals (Sweden)

    Bernabé Escobar Pérez

    2004-06-01

    Full Text Available En el entorno actual, las empresas se plantean como uno de sus objetivos prioritarios la reducción de costes en formas que no comprometan su supervivencia. Por ello, nos hemos propuesto en este trabajo aportar evidencia sobre (1 la importancia de la información suministrada por la Contabilidad de Gestión para la mejora de sus procesos de cara a alcanzar los objetivos de la compañía, en nuestro caso la reducción de costes y el afianzamiento de su liderazgo en este aspecto dentro de su grupo y (2 el papel que juegan los elementos del sistema de control para la realización de esta estrategia. Para su consecución hemos desarrollado un estudio de caso longitudinal en la filial española de un grupo químico multinacional que implantó a mediados de los 90 un programa para la reducción progresiva de sus costes, en el que se puede apreciar las consecuencias de la creación de círculos de calidad y la introducción de prácticas de benchmarking, así como la importancia de los componentes formalizados y no formalizados del sistema de control para lograr el éxito del programa. One of the contemporary organizations' priorities is to face cost reduction without dramatically affecting the organization 's survival Thus, the aim of this paper is to provide evidence on (1 the importance of Management Accounting information for cost reduction purposes and (2 the role of some Control System components in order to carry out this strategy. A longitudinal case study has been carried out at a Spanish subsidiary of a multinational chemical group in order to attain the study's objectives. This chemical plant introduced a cost reduction project in the mid 1990's. The most salient results were on the one hand, the implementation of quality circles and infernal benchmarking practices and, on the other hand the importance of both formal and non-formal Control System components in order to successfully achieve the project's objectives.

  8. El rol del tutor en un ambiente virtual de aprendizaje para la formación continua de docentes

    Directory of Open Access Journals (Sweden)

    Juan Eusebio SILVA QUIROZ

    2016-04-01

    Full Text Available El potencial comunicativo de las tecnologías de la información y comunicación (TIC está transformando los ambientes de enseñanza y aprendizaje en los cuales han sido introducidas. Esta introducción ha adoptado, principalmente, dos formas: formación en línea o como complemento a la clase presencial. Estas tecnologías permiten la creación de entornos virtuales, bajo enfoques metodológicos no tradicionales, transitando desde un aprendizaje individual a un aprendizaje colaborativo, desde la transmisión a la construcción de conocimiento. En estos entornos, el rol del tutor es determinante para el éxito de una actividad formativa centrada más en la colaboración y construcción de conocimiento en red. Este artículo presenta los resultados preliminares de una investigación que busca conocer y caracterizar el rol pedagógico del tutor en la animación de los ambientes asíncronos de un espacio virtual de aprendizaje, en el contexto de un curso de formación a distancia para docentes.

  9. Continuous innovation, socially sustainable, environmental correct and brazilian legitimate; Inovacao continua, socialmente sustentavel, ambientalmente correta e legitimamente brasileira

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Valdemar Stelita [NovoCell Sistemas de Energia S.A, Americana, SP (Brazil)

    2006-07-01

    This paper presents an overview on fuel cells, considering the following aspects: 2 years development programs; integration of disruptive technologies; pos demonstration market of the unities; new Brazilian markets on distributed generation; development of new materials, processes and conception of production equipment; proprietor processes; innovator characteristics - UTHC plates.

  10. Diseño de polvos de molde para colada continua de slabs de aceros bajo carbono

    Directory of Open Access Journals (Sweden)

    Cruz-Ramírez, A.

    2004-02-01

    Full Text Available Commercial fluxes were characterized by laboratory tests, and their original properties were changed with additions of chemical reagents in order to establish criteria and design strategies to produce new fluxes. The characterization of the commercial fluxes reveals that they are produced by simple mechanical blend of minerals, using feldspars and clays as base materials, containing SiO2, Al2O3, Na2 O and in less quantity K2O, MgO, Fe2 O3and MnO; limestone as the main source of CaO, fluorspar (CaF2 used to control the viscosity and graphite as carbon source. Melting-solidification tests revealed melting and fluidity temperatures and the existence of abundant mineralogical phases formed during the flux solidification. Some important mineralogical compounds are the nepheline (NaAlSiO4 and cuspidine (Ca4Si2O7F2; these species have a direct influence on the heat transfer phenomena from strand to mold and therefore on the phase transformations and the shrinkage of the steel.

    A partir de la caracterización de polvos comerciales mediante pruebas de laboratorio y la modificación de sus propiedades mediante adiciones de compuestos químicos, se identificaron y desarrollaron criterios y estrategias de diseño que sirvieron de base para elaborar nuevos polvos. La caracterización de los polvos comerciales indica que se fabrican por simple mezcla mecánica de minerales, utilizando feldespatos y arcillas como materiales base, que contienen SiO2, Al2O3, Na2 O y, en menor proporción, K 2O, MgO, Fe2 O3 y MnO, caliza como fuente principal de CaO, fluorita (CaF2 como fluidificante y grafito como fuente de carbono. Mediante pruebas de fusión-solidificación se determinaron las temperaturas de fusión y fluidez de los polvos y se identificó una gran variedad de especies cristalinas que se forman durante la solidificación, entre las que destacan la nefelina (NaAlSiO4 y la cuspidina (Ca4Si2O7F2, que tienen una influencia directa sobre los fenómenos de transferencia de calor de la línea al molde y, por lo tanto, en la velocidad de transformación de fases y de contracción del acero.

  11. Hidratación oral continua o a dosis fraccionadas en niños deshidratados por diarrea aguda

    Directory of Open Access Journals (Sweden)

    Mota-Hernández Felipe

    2002-01-01

    Full Text Available Objetivo. Evaluar la seguridad y efectividad de dos técnicas de hidratación oral. Material y métodos. Ensayo clínico aleatorio, hecho en el Servicio de Hidratación Oral del Hospital Infantil de México, Federico Gómez, entre septiembre de 1998 y junio de 1999. Cuarenta pacientes deshidratados por diarrea aguda, menores de cinco años, recibieron suero oral ad libitum (grupo AL y otros cuarenta lo recibieron en dosis fraccionada (grupo DF. Las características clínicas fueron similares en ambos grupos. Los resultados se presentan como promedio y desviación estándar o mediana, según la distribución de frecuencias simples y relativas. Resultados. El promedio de gasto fecal en el grupo AL fue 11.0±7.5 g/kg/h y en el grupo DF 7.1±7.4 (p=0.03. La ingesta de suero, el tiempo de hidratación y la diuresis promedio, fueron similares entre ambos grupos (p>0.05. Seis pacientes del grupo AL y cinco del DF tuvieron gasto fecal alto (>10 g/kg/hora, mejorando con la administración de atole de arroz. Un paciente del grupo AL y dos pacientes del DF tuvieron vómitos persistentes, mejorando con gastroclisis. Ningún paciente requirió rehidratación intravenosa. Conclusiones. Estos resultados sugieren que la administración de suero oral ad libitum, bajo supervisión, es tan segura y efectiva como la técnica de dosis fraccionada para el tratamiento de niños deshidratados por diarrea aguda.

  12. Understanding Translanguaging Practices through a Biliteracy Continua Framework: Adult Biliterates Reading Academic Texts in Their Two Languages

    Science.gov (United States)

    Kwon, Hyun Joo; Schallert, Diane L.

    2016-01-01

    Ten adult readers, advanced in their control of two languages, Korean and English, were recruited for a study of academic literacy practices to examine the various linguistic repertoires on which they drew. Analysis of their language use revealed many instances of "translanguaging," that is, a flexible reliance on two languages to serve…

  13. Análisis de costes y prestaciones de sistemas de transporte público colectivo mediante aproximaciones continuas

    OpenAIRE

    Herrero Tomás, Mª Dolores

    2014-01-01

    El estudio que a continuación se desarrolla pretende realizar una comparativa de costes entre los diferentes modos de transporte público urbano. El estudio elaborado considera los principales modos que discurren por las ciudades, concretamente: autobús convencional, autobús propulsado por energías limpias (GNL, híbrido y eléctrico), BRT, tranvía y metro. El transporte público cuenta de inicio con unos costes más elevados que el transporte privado y, en muchas ocasiones, las tarifas c...

  14. Continuous improvement of environmental aspect in Juzbado factory; Mejora continua del comportamiento ambiental de la fabrica de Juzbado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    ENUSA's Fuel Assembly Factory in Juzbado (Salamanca), conscious of its responsibilities with the environment where its activities are carried out, has an Environmental Management System (EMS) certified by AENOR (N. CGM-99/31) according to the requirements of Standard UNE{sub E}N-ISO 14001 and afterwards, as a result of compromise with continuous improvement of its environmental performance, joined the European Regulation 761/2001(EMAS), which has allowed the EMS to achieve levels of excellence in environmental management, doing it in a much more transparent and participative way and letting the public and other interested parts to have access to the information referring its environmental activities, as demanded by society, by the elaboration and verification of an Environmental Statement (VDM-03/010) on a yearly basis. (Author)

  15. Brain spect in the pre-surgical evaluation of epileptic patients preliminary results

    Directory of Open Access Journals (Sweden)

    Carlos A. Buchpiguel

    1992-03-01

    Full Text Available Pre-surgical evaluation of epileptic patients consists of neurological examination, intensive electroencephalographic (EEG monitoring and anatomical studies (CT and MRI. Functional methods such as PET and SPECT imaging are now used more frequently. We have studied pre-operatively 15 adult epileptic patients (8 female, 7 male using a rotational scintillation camera interfaced to a dedicated computer. The tomographic images were obtained 15 minutes after intravenous injection of 99mTc_HMPAO. All had MRI scanning and intensive EEG monitoring which generally included seizure recording. Five patients had progressive lesions (3 meningiomas, 2 astrocytomas. In 10 patients, neuroradiological studies did not show the presence of progressive lesions (2 normal scans and 8 cases with inactive lesions. Two patients with meningioma showed hypoperfusion at the lesion site while the third patient had a marked hyperperfusion which might correlate with the clinical diagnosis of epilepsia partialis continua. In the astrocytoma patients SPECT scans showed hypoperfusion at the lesion site. Data obtained from the 10 patients without progressive CNS lesions showed: (a in 4, SPECT findings correlated well with the anatomical findings; (b in 5 instances, SPECT was able to disclose additional functional deficits; (c in one case, there was no SPECT correlate of a discrete anatomical lesion. In 5 of these cases with no progressive lesions (n=10 SPECT findings were useful as a complementary tool in determining the clinical or surgical management of these patients. Despite the small number and hete-rogenicity of the present sample, SPECT seems to be an useful tool as part of the clinical workup of epileptic patients who are candidates for epilepsy surgery.

  16. Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

    Science.gov (United States)

    Mader, Edward C.; El-Abassi, Rima; Villemarette-Pittman, Nicole R.; Santana-Gould, Lenay; Olejniczak, Piotr W.; England, John D.

    2013-01-01

    The clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is largely based on the 1998 World Health Organization diagnostic criteria. Unfortunately, rigid compliance with these criteria may result in failure to recognize sporadic CJD (sCJD), especially early in its course when focal findings predominate and traditional red flags are not yet present. A 61-year-old man presented with a 3-week history of epilepsia partialis continua (jerking of the left upper extremity) and a 2-week history of forgetfulness and left hemiparesis; left hemisensory neglect was also detected on admission. Repeated brain magnetic resonance imaging (MRI) showed areas of restricted diffusion in the cerebral cortex, initially on the right but later spreading to the left. Electroence-phalography (EEG) on hospital days 7, 10, and 14 showed right-sided periodic lateralized epileptiform discharges. On day 20, the EEG showed periodic sharp wave complexes leading to a diagnosis of probable sCJD and subsequently to definite sCJD with brain biopsy. Neurological decline was relatively fast with generalized myoclonus and akinetic mutism developing within 7 weeks from the onset of illness. CJD was not immediately recognized because of the patient's focal/lateralized manifestations. Focal/lateralized clinical, EEG, and MRI findings are not uncommon in sCJD and EEG/MRI results may not be diagnostic in the early stages of sCJD. Familiarity with these caveats and with the most current criteria for diagnosing probable sCJD (University of California San Francisco 2007, MRI-CJD Consortium 2009) will enhance the ability to recognize sCJD and implement early safety measures. PMID:23717780

  17. Neurocysticercosis in Nepal: a retrospective clinical analysis

    Directory of Open Access Journals (Sweden)

    Rajeev Ojha

    2015-01-01

    Full Text Available Aim: The prevalence of epilepsy is higher in Nepal. This study was conducted to analyze the clinical manifestations of neurocysticercosis (NCC among seizure patients admitted to our center. Methods: We retrospectively studied all the NCC patients admitted to Neurology Department, Bir Hospital, Kathmandu, Nepal from April 2012 to February 2014. Computer tomography/magnetic resonance imaging (CT/MRI head, clinical profile, lab investigations and exclusion of other causes were the basis of the NCC diagnosis. Chi-square and Student′s t-test were used for comparison of variables. Results: Out of 131 seizure patients admitted, 21 patients were diagnosed with NCC (mean age: 33.95 ± 16.41; male: 15 (71.4%, female: 6 (28.6%. Generalized tonic clonic seizure was the most common seizure type in NCC patients (18 patients; 85.7%, two of them had status epilepticus during presentation in Emergency Department. Three patients had focal seizure, one with epilepsia partialis continua. Neuroimaging showed multiple NCC lesions in 8 (38.1% and a single NCC lesion in 13 (61.9% patients. Seven of them (33.3% sought traditional healers before being presented to our center. Eight patients (38.1% were treated with antiepileptics in local health-post without neuroimaging studies done. Calcified stage of NCC was the most frequent CT/MRI findings (12 patients; 57.1%. Phenytoin was preferred both by physicians and patients due to its low cost. Conclusion: NCC is a common finding among seizure patients in Nepal. Poor economic status, illiteracy and underdeveloped rural society are the major challenges in prevention and treatment of NCC.

  18. Peri-ictal signal changes in seven patients with status epilepticus: interesting MRI observations

    Energy Technology Data Exchange (ETDEWEB)

    Goyal, Manoj K; Sinha, Sanjib [National Institute of Mental Health and Neurosciences (NIMHANS), Department of Neurology, Bangalore, Karnataka (India); Ravishankar, Shivshankar; Shivshankar, Jai Jai [National Institute of Mental Health and Neurosciences (NIMHANS), Department of Neuroimaging and Interventional Radiology, Bangalore (India)

    2009-03-15

    Transient peri-ictal changes on imaging had been described following status epilepticus (SE), but its cause is not very well understood. We analyzed the magnetic resonance imaging (MRI) findings in SE patients in order to elucidate such changes including peri-ictal signal. This prospective study involved 34 patients (M/F 23:11, mean age 25.8 {+-} 17.2 years) who experienced SE. MRI was performed during or within 96 h of cessation of seizures. Twenty-five patients had generalized convulsive status epilectus (GCSE; ten secondary GCSE and 15 primary GCSE). Seven patients had epilepsia partialis continua and two patients non-convulsive SE. Eight patients had a history of seizures and three patients previous SE. The mean duration of SE prior to MRI was 89.2 {+-} 105.3 h (range 2-360 h). MRI provided diagnosis in 17 patients, and in 13 patients, no structural cause was identified. Peri-ictal focal signal changes with restricted diffusion on apparent diffusion coefficient maps were present in seven (20.6%) patients with SE (generalized convulsive, three; partial, three; non-convulsive, one). The changes were observed when MRI was performed during SE in 3/10 (30%) patients, or within 24 h in 1/7 (14.3%), 48 h in 1/5 (20%), 72 h in 1/6 (16.7%), or 96 h in 1/6 (16.7%) patients after cessation of seizures. Repeat MRI revealed disappearance of signal changes in two patients. Peri-ictal MR changes with restricted diffusion appear to be an effect rather than the cause of SE. (orig.)

  19. Peri-ictal signal changes in seven patients with status epilepticus: interesting MRI observations

    International Nuclear Information System (INIS)

    Goyal, Manoj K.; Sinha, Sanjib; Ravishankar, Shivshankar; Shivshankar, Jai Jai

    2009-01-01

    Transient peri-ictal changes on imaging had been described following status epilepticus (SE), but its cause is not very well understood. We analyzed the magnetic resonance imaging (MRI) findings in SE patients in order to elucidate such changes including peri-ictal signal. This prospective study involved 34 patients (M/F 23:11, mean age 25.8 ± 17.2 years) who experienced SE. MRI was performed during or within 96 h of cessation of seizures. Twenty-five patients had generalized convulsive status epilectus (GCSE; ten secondary GCSE and 15 primary GCSE). Seven patients had epilepsia partialis continua and two patients non-convulsive SE. Eight patients had a history of seizures and three patients previous SE. The mean duration of SE prior to MRI was 89.2 ± 105.3 h (range 2-360 h). MRI provided diagnosis in 17 patients, and in 13 patients, no structural cause was identified. Peri-ictal focal signal changes with restricted diffusion on apparent diffusion coefficient maps were present in seven (20.6%) patients with SE (generalized convulsive, three; partial, three; non-convulsive, one). The changes were observed when MRI was performed during SE in 3/10 (30%) patients, or within 24 h in 1/7 (14.3%), 48 h in 1/5 (20%), 72 h in 1/6 (16.7%), or 96 h in 1/6 (16.7%) patients after cessation of seizures. Repeat MRI revealed disappearance of signal changes in two patients. Peri-ictal MR changes with restricted diffusion appear to be an effect rather than the cause of SE. (orig.)

  20. Early Psychosocial Stress Predicts Extra-Pair Copulations

    Directory of Open Access Journals (Sweden)

    Nicole Koehler

    2007-01-01

    Full Text Available Cheating on a mate, known as an extra-pair copulation (EPC, is considered unacceptable by most individuals. Nonetheless many individuals engage in such risky behaviors. Because individuals with high, as opposed to low, levels of early psychosocial stress are more risk prone and more likely to engage in opportunistic matings, we predicted that individuals reporting EPCs, one of many types of opportunistic mating (e.g., one-night stand, consecutive short-term relationships etc, have higher levels of early psychosocial stress than those who do not. Two types of EPCs were examined: EPC-self (EPC-S, having sex with someone other than one's mate, and EPC-other (EPC-O, having sex with someone else's mate. In a sample of 229 women and 161 men, significantly higher levels of early psychosocial stress were found amongst those reporting an EPC-S than those reporting none, irrespective of EPC-Os. Furthermore, the more EPC-Ss men, but not women, reported the higher their early psychosocial stress. Early psychosocial stress was not associated with EPC-Os irrespective of EPC-Ss. Participants were also classified into one of four groups (no EPCs, EPC-O only, EPC-S only, or EPC-S&O which significantly interacted with early psychosocial stress. Results are discussed from adaptationist and mechanist perspectives and why early psychosocial stress was higher in individuals reporting EPC-Ss irrespective of EPC-Os, but not EPC-Os irrespective of EPC-Ss, than those not reporting the EPC of interest.

  1. Co-digestion of incubatory wastes and agroindustrial wastewaters: continuous phase; Co-digestao de residuos de incubatorio de aves e aguas residuarias agroindustriais: fase continua

    Energy Technology Data Exchange (ETDEWEB)

    Matter, Juliana M; Costa, Monica Sarollis S. de M.; Costa, Luiz A. de M.; Martins, Marcos F. Leal , [Universidade Estadual do Oeste do Parana (UNIOESTE), Cascavel, PR (Brazil)

    2011-07-01

    The waste from poultry hatchery, one of the production chain of chicken, generate a considerable volume of material with high pollution potential. The aim of this study was to examine the feasibility of utilization of waste through anaerobic co-digestion. For testing we used 20 digesters, each with a capacity of 60L, simulating horizontal tubular digester. Five treatments were tested with 2% ST: T{sub 1}: + hatchery drained water equalization tank. T{sub 2}: Waste + hatchery water drained from the first anaerobic pond agribusiness. T{sub 3}: Waste hatchery fresh water + the first anaerobic pond of the hatchery. T{sub 4}: cool + hatchery residue remaining wastewater. T{sub 5} (Mixed): Waste of hatchery fresh water + the first anaerobic pond of the hatchery + swine wastewater. Were determined the potential for biogas production and methane and the methane percentage in biogas. The co-digestion was efficient treatment for the waste where treatments T{sub 4} and T{sub 5} the best medium for reaching potential of biogas production and methane. All treatments showed satisfactory percentage of methane in the biogas composition. (author)

  2. Efficacia e indicazioni del counseling e delle strategie educative nel miglioramento della compliance alla ventilazione a pressione positiva continua – CPAP

    Directory of Open Access Journals (Sweden)

    Elena Peila

    2017-07-01

    Conclusioni: Le strategie educative sono tecniche efficaci per migliorare l'adrenza alla CPAP anche in popolazioni che abitualmente presentano bassa compliance come i pazienti senza beneficio soggettivo dalla terapia con CPAP o pazienti con comorbilità psichiatrica o cognitiva. Tuttavia sono raccomandati interventi educativi brevi.

  3. Estudio preliminar de la creación de una “zona caliente” en YBa2Cu3O7-δ utilizando una corriente continua

    Directory of Open Access Journals (Sweden)

    Evetts, J. E.

    1999-12-01

    Full Text Available This work presents a study of the processes that give rise to the Direct Current Zoning effect. This effect consists in the formation of a hot zone in a superconducting rod when a potential difference is applied to it. The superconducting material used in this case was YBa2Cu3O7-δ. The formation and movement of the zone in the bar can be explained studying the balance between the ionic fluxes created due to the potential difference and to the temperature distribution along the bar. This paper presents the theoretical results obtained using a computer model developed that takes into account the processes of electromigration and ionic diffusion that give rise to the Direct Current Zoning effect.Este trabajo presenta un estudio de los procesos que dan lugar al fenómeno en el que un “punto” o zona caliente se forma al aplicar una diferencia de potencial a los extremos de una barra de óxido superconductor. El material superconductor utilizado en este caso es YBa2Cu3O7-δ. El equilibrio entre los flujos iónicos debidos a la diferencia de potencial y a la distribución de temperatura se han utilizado para explicar la formación y el movimiento de la zona a lo largo de la muestra. Este artículo presenta los resultados teóricos obtenidos utilizando un modelo que tiene en cuenta los procesos de electromigración y difusión iónica que dan lugar a este fenómeno.

  4. New insights from a statistical analysis of IUE spectra of dwarf novae and nova-like stars. I - Inclination effects in lines and continua

    Science.gov (United States)

    La Dous, Constanze

    1991-01-01

    IUE observations of dwarf novae at maximum at quiescence and novalike objects at the high brightness state are analyzed for effects of the inclination angle on the emitted continuum and line radiation. A clear pattern in the continuum flux distribution is exhibited only by dwarf novae at maximum where some 80 percent of the non-double-eclipsing systems show essentially identical distributions. This result is not in disagreement with theoretical expectations. All classes of objects exhibit a clear, but in each case different, dependence of the line radiation on the inclination angle.

  5. COMPARACIÓN DE DOS PRUEBAS DE RESISTENCIA AERÓBICA CONTINUA E INTERMITENTE EN CONDICIONES DE ALTURA INTERMEDIA EN ÁRBITROS DE FÚTBOL

    Directory of Open Access Journals (Sweden)

    William Orlando Gamboa Carmona

    2009-06-01

    Full Text Available El árbitro de futbol tiene un nivel de exigencia cada vez mayor, es, por eso, que la Federación Internacionalde Fútbol Asociado Fifa aplica un test para evaluar el rendimiento físico y busca unosindicadores para tener un control sobre ellos. El árbitro de fútbol realiza una distancia de 9 a 13kilómetros durante un partido, en los que no está corriendo seguidamente y tiene pausas de descanso,es por eso que el árbitro debe ser evaluado con un test que se asemeje a lo que recorre en unpartido de fútbol. Por estas razones, esta investigación pretende dar respuesta al interrogante de:¿Existen diferencias en el rendimiento de jueces de fútbol medido en el YYTRI y el test de Cooper?

  6. Estrategias de un Call Center de telecomunicaciones para la mejora continua de la calidad con enfoque en la satisfacción del cliente.

    OpenAIRE

    Nolivos Balarezo, Jaime Danilo

    2012-01-01

    198 hojas : ilustraciones, 29 x 21 cm + CD-ROM 4168 El objetivo de esta tesis es definir las estrategias a seguir para el mejoramiento continuo de la calidad con enfoque en la satisfacción del cliente, que al aplicar en el Centro de Soporte de Datos de Movistar mejore los niveles de desempeño del personal y la imagen de la empresa frente a sus clientes. Capítulo 1. Introducción al Call Center, funcionamiento y factores críticos de éxito. Aspectos importantes de la empresa y descripción de ...

  7. Reaprender a enseñar: una experiencia de formación para la mejora continua de la docencia universitaria

    Directory of Open Access Journals (Sweden)

    Rosa María Rodríguez Izquierdo

    2003-01-01

    Full Text Available Con este artículo tratamos de poner en común una experiencia de investigación-acción, en proceso de construcción, basada en la elaboración de Guías de Didácticas de Trabajo para los estudiantes de Magisterio del Centro Superior de Enseñanza Cardenal Spinola de Sevilla. El trabajo a través de Guías Didácticas constituye un intento de explorar nuevas metodologías de trabajo universitario que favorezcan la motivación de los alumnos en los procesos de enseñanza-aprendizaje, el aprendizaje activo como alternativa a la lección magistral y el gusto por el conocimiento y el aprendizaje.

  8. The continuous improvement system of nuclear power plant of Laguna Verde; El sistema de mejora continua de la central nucleoelectrica Laguna Verde

    Energy Technology Data Exchange (ETDEWEB)

    Rivera C, A. [Comision Federal de Electricidad, Central Nucleoelectrica Laguna Verde, Km. 42.5 Cardel-Nautla, Veracruz (Mexico)], e-mail: arr99999@cfe.gob.mx

    2009-10-15

    This paper describes the continuous improvement system of nuclear power plant of Laguna Verde and the achievements in implementing the same and additionally two study cases are presents. In February 2009 is noteworthy because the World Association of Nuclear Operators we identified as a learning organization, qualification which shows that the continuous improvement system has matured, and this system will expose as I get to learn to capitalize on our own experiences and external experiences diffused by the nuclear industry. In 2007 the management of nuclear power plants integrates its improvement systems and calls it continuous improvement system and is presented in the same extensive report that won the National Quality Award. This system is made up of 5 subsystems operating individually and are also related 1) human performance; 2) referential comparison or benchmarking; 3) self-assessment; 4) corrective action and 5) external operating experience. Five subsystems that plan, generate, capture, manage, communicate and protect the knowledge generated during the processes execution of nuclear power plant of Laguna Verde, as well as from external sources. The target set in 2007 was to increase the intellectual capital to always give response to meeting the security requirements, but creating a higher value to quality, customer, environment protection and society. In brief each of them, highlighting the objective, expectations management, implementation and some benefits. At the end they will describe two study cases selected to illustrate these cases as the organization learns by their continuous improvement system. (Author)

  9. Knee cooled radiofrequency vs continuous radiofrequency for genicular neurotomy: preliminary experience - Crio-radiofrequenza vs radiofrequenza continua per neurotomia dei nervi genicolati: esperienza preliminare

    Directory of Open Access Journals (Sweden)

    Alfonso Papa

    2016-09-01

    Full Text Available Radiofrequency neurotomy of genicular nerves has been often used as an efficacious treatment option in all patients suffering from chronic osteoarthritis pain to provide long-term pain relief. After providing informed written consent, 80 patients with severe knee chronic osteoarthritis pain had been enrolled; patients had been divided into two groups (Group C, crioneurolysis, vs Group R, traditional radiofrequency, 40 patients for each group. Pain relief in C group was poorer and with shorter time in duration (median NRS reducing from 8 to 5. Radiofrequency can be considered as an effective, minimally invasive treat­ment for these kinds of conditions, and offers the benefit of being a fast procedure with long-term pain relief.

  10. Diseño de un modelo de mejora continua de la gestión de proyectos para Anónima Operadora de Pensiones Complementarias

    OpenAIRE

    Álvarez-Gamboa, Manuel; Arce-Oses, Oscar Esteban

    2011-01-01

    Proyecto Final de Graduación (Máster en Gerencia de Proyectos) Instituto Tecnológico de Costa Rica. Escuela de Administración de Empresas. Escuela de Ingeniería en Computación. Escuela de Ingeniería en Construcción, 2011. The study explores the continuous improvement of the project management processes in ANÓNIMA OPC. The problem was defined as the identification of the features that a continuous improvement model must have, in order to encourage the organization taking advantage of the le...

  11. Measurement of uranium concentration by molecular absorption spectrophotometry by means optical fibers; Medicion continua de concentracion de uranio por espectrofotometria de absorcion molecular mediante fibras opticas

    Energy Technology Data Exchange (ETDEWEB)

    Gauna, Alberto C.; Pascale, Ariel A. [Comision Nacional de Energia Atomica, Buenos Aires (Argentina). Centro Atomico Ezeiza. Agencia Minipost

    1996-07-01

    An on-line method for measuring the concentration of uranium in uranyl nitrate-nitric acid aqueous solutions is described. The method is based on molecular absorption spectrophotometry with transmission of light by means of optical fibers. It is ideally suited for control and processes development applications. (author)

  12. Organisational learning: A tool for continuous improvement of the organization; Aprendizaje Organizativo: una herramienta para la mejora continua de la organizacion

    Energy Technology Data Exchange (ETDEWEB)

    Santos, J. L.; Esteban, M. J.

    2013-09-01

    We are used to hear a success company in today's world is not possible unless a continuous improvement is developed. How can we be successful in the nuclear plant? We have to achieve safety for workers, people and environment in the first step, and for the second step availability and reliability for systems and components to avoid failure of components that could reduce availability. The aim is to search for new measures to reach this way. One of the improvements implemented in the plants to improve continuously was mainly Operating Experience activities, which was based in event analysis in the plants, causes identification, and to implement corrective actions. For External Operating Experience the aim was to learn from others to avoid occurrence of events in our plants. This was the lessons learned from Three Mile Island event. This was the learning process implemented so far, to get a continuous improvement. So far, the developed capabilities for process improvement follow the Operating Experience process that could be considered classical and will be revitalized nowadays. (Author)

  13. Perspectiva histórica de la Revista Científica Ciencia Médica: un proceso de evolución continua

    OpenAIRE

    Karla P. Romero-Ledezma

    2011-01-01

    La Revista Científica Ciencia Médica inició su edición el año 1997 a fin de incentivar a estudiantes de pregrado a difundir el producto de sus investigaciónes, a través de un medio impreso, siendo una de las primeras revistas científicas de pregrado adoptando la revisión por pares. La idea que nace en el seno de la Sociedad Científica de Estudiantes de Medicina (SCEM) de la Universidad Mayor de San Simón (UMSS), con la que se conformó un comité editorial y un comité revisor-asesor. Se publica...

  14. Perspectivas de utilización de los métodos de modulación digital con fase continua en los sistemas de telecomunicaciones modernos

    Directory of Open Access Journals (Sweden)

    Germán Castellanos

    1993-01-01

    Full Text Available Se describen los principales tipos de modulación digital con envolvente constante, que se están desarrollando en sistemas de telecomunicaciones, entre ellos la modulación de fase cuaternaria (QPSK y OQPSK. La modulación de fase continúa que presentan mejores propiedades con respecto a otros tipos digitales. Por ejemplo, mayor fidelidad en radiocanales no lineales (caracterfsticos en la telecomunicación móvil celular y vía satélite, menores niveles de energía fuera de banda, etc. En especial se describen las señales MSK y su variedad con filtración preliminar gaussiana GMSK que se emplean ampliamente en los sitemas de comunicación móbil celular digitales, por poseermenores mayores niveles de energía dentro de la banda de trabajo, fidelidad potencial máxima, mejor compatibilidad electromagnética con otros radiosistemas, etc. Se analizan las principales tendencias de desarrollo de los tipos de modulación digital MSK.

  15. A OMC Continua Promovendo o Comércio de Forma Desigual: Novas Evidências a Partir dos Anos 1990

    Directory of Open Access Journals (Sweden)

    Magnus dos Reis

    2015-09-01

    Full Text Available O artigo fornece evidências de que a OMC continuou tendo um impacto profundo sobre o comércio de seus países membros, no período 1990–2009, seguindo a contribuição original de Subramanian & Wei (2007. Para isto, utilizouse o modelo gravitacional, através de efeitos fixos e com o estimador da PMVP, comparando a magnitude da abertura multilateral, entre países desenvolvidos e em desenvolvimento. Os resultados sugerem que os países em desenvolvimento, no período examinado, foram os que mais se beneficiaram do aumento do comércio mundial promovido pela OMC, ao contrário do que havia ocorrido, entre 1950 e 2000, conforme Subramanian & Wei (2007.

  16. Flow modelling in fractured aquifers, development of multi-continua model (direct and inverse problems) and application to the CEA/Cadarache site

    International Nuclear Information System (INIS)

    Cartalade, Alain

    2002-01-01

    This research thesis concerns the modelling of aquifer flows under the CEA/Cadarache site. The author reports the implementation of a numerical simulation tool adapted to large scale flows in fractured media, and its application to the Cadarache nuclear site. After a description of the site geological and hydrogeological characteristics, the author presents the conceptual model on which the modelling is based, presents the inverse model which allows a better definition of parameters, reports the validation of the inverse approach by means of synthetic and semi-synthetic cases. Then, he reports experiments and simulation of the Cadarache site

  17. Plataforma de auditoría continua de sistemas de información basada en el análisis de riesgos y Business Intelligence

    OpenAIRE

    Tablado Félix, Luis Gabriel

    2015-01-01

    La Auditoría de Sistemas de la Información es un campo de la Informática que no suele ser tenido en cuenta en entornos académicos. Su rol de tarea de cumplimiento normativo tradicionalmente la ha relegado a un segundo plano dentro de las disciplinas que se tratan en Ingeniería Informática. Más allá del puro rol de cumplimiento la Auditoría de Sistemas de la Información proporciona a las organizaciones un mayor control sobre sus procesos de tecnología de la información así co...

  18. Radio continua modulated by waves: Zebra patterns in solar and pulsar radio spectra?n in the 2001 June 15 flare

    Czech Academy of Sciences Publication Activity Database

    Karlický, Marian

    2013-01-01

    Roč. 552, April (2013), A90/1-A90/6 ISSN 0004-6361 R&D Projects: GA ČR GAP209/12/0103 Grant - others:EU(XE) PIRSES-GA-2011-295272 Institutional support: RVO:67985815 Keywords : Sun * radio radiation * pulsar s Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.479, year: 2013

  19. Aplicando Scrum y Prácticas de Ingeniería de Software para la Mejora Continua del Desarrollo de un Sistema Ciber-Físico

    Directory of Open Access Journals (Sweden)

    Gabriela Sobrevilla

    2017-05-01

    Full Text Available En la actualidad, presiones competitivas fuerzan a las compañías a desarrollar productos y servicios en el menor tiempo posible. Una alternativa para lograrlo es el uso de métodos de desarrollo ágiles como Scrum. A pesar de que Scrum ha sido usado exitosamente en muchos dominios de aplicación, no existe un claro entendimiento sobre cómo aspectos específicos del desarrollo de Sistemas Ciber-Físicos deben ser tratados cuando se utiliza este método sin que afectar la agilidad. En este artículo se describen algunos problemas técnicos y organizacionales que surgieron durante el desarrollo de un Sistema Ciber-Físico y cómo se resolvieron incorporando algunas prácticas de ingeniería de software. Compartiendo esta experiencia se pretende ayudar a otros equipos de desarrollo a ganar un mejor entendimiento sobre algunos de los problemas relacionados a este tipo de sistemas y cómo enfrentarlos con las prácticas descritas.

  20. Manómetros de burbuja para realizar mediciones continuas de la presión de raíz en los cultivos tropicales

    Directory of Open Access Journals (Sweden)

    Marco V. Guti\\u00E9rrez-Soto

    2011-01-01

    Se discute la importancia de la medición y las posibilidades para el control de la presión de raíz en el manejo de la zona radical de los cultivos, mediante la intervención tanto de las propiedades físicas, químicas y biológicas del suelo y los sustratos, especialmente alrededor de la rizosfera, como del ambiente aéreo de las plantas cultivadas.

  1. Simulación hidrológica continua en la cuenca del río Cuareim con el modelo MGB-IPH

    Directory of Open Access Journals (Sweden)

    Magdalena Crisci

    2015-12-01

    Full Text Available La creciente intensificación de la demanda de agua, por un lado, y el aumento de la demanda atmosférica y de la variabilidad climática (asociados al cambio climático, por otro, ponen de manifiesto la necesidad de contar con herramientas de modelación hidrológica para la gestión sustentable de los recursos hídricos en Uruguay. En este trabajo se presenta el análisis, la implementación y la calibración del modelo hidrológico MGB-IPH (Collischonn, et al., 2007 de paso diario en la cuenca del río Cuareim, en la cual existe una gran competencia por el uso del agua, fundamentalmente para el riego de arroz. El análisis del modelo permitió asociar sus parámetros más importantes a datos físicos conocidos en la cuenca (y en todo el país, así como reconocer aquellos parámetros más sensibles. La implementación y la calibración del modelo en la cuenca del río Cuareim permitió obtener una parametrización que representa muy adecuadamente los caudales observados en dicha cuenca (R2=0.88, NS=0.77 y que puede ser implementado en otras cuencas del país, teniendo en cuenta los parámetros físicos de las mismas.

  2. The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues

    OpenAIRE

    Kamei, Naosuke; Atesok, Kivanc; Ochi, Mitsuo

    2017-01-01

    Endothelial progenitor cells (EPCs) derived from bone marrow and blood can differentiate into endothelial cells and promote neovascularization. In addition, EPCs are a promising cell source for the repair of various types of vascularized tissues and have been used in animal experiments and clinical trials for tissue repair. In this review, we focused on the kinetics of endogenous EPCs during tissue repair and the application of EPCs or stem cell populations containing EPCs for tissue regenera...

  3. Prospective study of POLG mutations presenting in children with intractable epilepsy: prevalence and clinical features.

    Science.gov (United States)

    Uusimaa, Johanna; Gowda, Vasantha; McShane, Anthony; Smith, Conrad; Evans, Julie; Shrier, Annie; Narasimhan, Manisha; O'Rourke, Anthony; Rajabally, Yusuf; Hedderly, Tammy; Cowan, Frances; Fratter, Carl; Poulton, Joanna

    2013-06-01

    because of the increased risk for VPA-induced liver failure in patients with POLG mutations. We recommend POLG gene testing for patients with intractable seizures and at least one elevated CSF lactate or suggestive brain MRI changes (predominantly abnormal T2 -weighted thalamic signal) with or without status epilepticus, epilepsia partialis continua, or liver manifestations typical for Alpers disease, especially when the disease course is progressive. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

  4. Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice.

    Directory of Open Access Journals (Sweden)

    Lin Wang

    Full Text Available Bone marrow (BM-derived endothelial progenitor cells (EPC have therapeutic potentials in promoting tissue regeneration, but how these cells are modulated in vivo has been elusive. Here, we report that RBP-J, the critical transcription factor mediating Notch signaling, modulates EPC through CXCR4. In a mouse partial hepatectomy (PHx model, RBP-J deficient EPC showed attenuated capacities of homing and facilitating liver regeneration. In resting mice, the conditional deletion of RBP-J led to a decrease of BM EPC, with a concomitant increase of EPC in the peripheral blood. This was accompanied by a down-regulation of CXCR4 on EPC in BM, although CXCR4 expression on EPC in the circulation was up-regulated in the absence of RBP-J. PHx in RBP-J deficient mice induced stronger EPC mobilization. In vitro, RBP-J deficient EPC showed lowered capacities of adhering, migrating, and forming vessel-like structures in three-dimensional cultures. Over-expression of CXCR4 could at least rescue the defects in vessel formation by the RBP-J deficient EPC. These data suggested that the RBP-J-mediated Notch signaling regulated EPC mobilization and function, at least partially through dynamic modulation of CXCR4 expression. Our findings not only provide new insights into the regulation of EPC, but also have implications for clinical therapies using EPC in diseases.

  5. Shear stress and interleukin-8 (IL-8) on the proliferation ...

    African Journals Online (AJOL)

    Endothelial progenitor cells (EPCs) derived from bone marrow, are also found ... into tissues and neovascularization, the cells are exposed to fluid shear stress. ... Both shear stress and IL-8 can influence the process of EPCs repair in wound.

  6. Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?

    LENUS (Irish Health Repository)

    King, Thomas F J

    2013-01-01

    Offspring birthweight is inversely associated with future maternal cardiovascular mortality, a relationship that has yet to be fully elucidated. Endothelial progenitor cells (EPCs) are thought to play a key role in vasculogenesis, and EPC numbers reflect cardiovascular risk.

  7. Hydrogel-embedded endothelial progenitor cells evade LPS and mitigate endotoxemia.

    Science.gov (United States)

    Ghaly, Tammer; Rabadi, May M; Weber, Mia; Rabadi, Seham M; Bank, Michael; Grom, John M; Fallon, John T; Goligorsky, Michael S; Ratliff, Brian B

    2011-10-01

    Sepsis and its complications are associated with poor clinical outcomes. The circulatory system is a well-known target of lipopolysaccharide (LPS). Recently, several clinical studies documented mobilization of endothelial progenitor cells (EPCs) during endotoxemia, with the probability of patients' survival correlating with the rise in circulating EPCs. This fact combined with endotoxemia-induced vascular injury led us to hypothesize that the developing functional EPC incompetence could impede vascular repair and that adoptive transfer of EPCs could improve hemodynamics in endotoxemia. We used LPS injection to model endotoxemia. EPCs isolated from endotoxemic mice exhibited impaired clonogenic potential and LPS exerted Toll-like receptor 4-mediated cytotoxic effects toward EPCs, which was mitigated by embedding them in hyaluronic acid (HA) hydrogels. Therefore, intact EPCs were either delivered intravenously or embedded within pronectin-coated HA hydrogels. Adoptive transfer of EPCs in LPS-injected mice improved control of blood pressure and reduced hepatocellular and renal dysfunction. Specifically, EPC treatment was associated with the restoration of renal microcirculation and improved renal function. EPC therapy was most efficient when cells were delivered embedded in HA hydrogel. These findings establish major therapeutic benefits of adoptive transfer of EPCs, especially when embedded in HA hydrogels, in mice with LPS-induced endotoxemia, and they argue that hemodynamic and renal abnormalities of endotoxemia are in significant part due to developing incompetence of endogenous EPCs.

  8. Adoption of electronic prescribing for controlled substances among providers and pharmacies.

    Science.gov (United States)

    Hufstader Gabriel, Meghan; Yang, Yi; Vaidya, Varun; Wilkins, Tricia Lee

    2014-11-01

    Electronic prescribing for Schedule II through V controlled substances was legalized in the United States by the Drug Enforcement Administration in June 2010. However, little information exists about adoption and use of the electronic prescribing of controlled substances (EPCS) at the national level. Therefore, the objective of this study is to present the first information about national trends surrounding the adoption and use of the newly allowed EPCS by providers and pharmacies in the United States. Trends of EPCS adoption and use were examined for the number of EPCS, number of pharmacies enabled to accept EPCS, and the number of providers prescribing controlled substances electronically. Using nationally representative transactional Surescripts data from July 2012 to December 2013, we examined EPCS trends. During the study period, the total number of EPCS increased from 1535 to 52,423, and the number and percentage of all pharmacies enabled for EPCS increased from 8768 (13%) to 20,498 pharmacies (30%). The proportion of all providers prescribing controlled substances electronically is currently 1%, but increasing steadily each month. There is a positive national growth for EPCS in pharmacy preparedness to accept EPCS, the number of EPCS prescriptions sent each month, and the number of providers with the ability to send EPCS.

  9. Comparative transcriptomic analysis of endothelial progenitor cells derived from umbilical cord blood and adult peripheral blood: Implications for the generation of induced pluripotent stem cells

    Directory of Open Access Journals (Sweden)

    Xiugong Gao

    2017-12-01

    Full Text Available Induced pluripotent stem cells (iPSCs offer the potential to generate tissues with ethnic diversity enabling toxicity testing on selected populations. Recently, it has been reported that endothelial progenitor cells (EPCs derived from umbilical cord blood (CB or adult peripheral blood (PB afford a practical and efficient cellular substrate for iPSC generation. However, differences between EPCs from different blood sources have rarely been studied. In the current study, we derived EPCs from blood mononuclear cells (MNCs and reprogrammed EPCs into iPSCs. We also explored differences between CB-EPCs and PB-EPCs at the molecular and cellular levels through a combination of transcriptomic analysis and cell biology techniques. EPC colonies in CB-MNCs emerged 5–7 days earlier, were 3-fold higher in number, and consistently larger in size than in PB-MNCs. Similarly, iPSC colonies generated from CB-EPCs was 2.5-fold higher in number than from PB-EPCs, indicating CB-EPCs have a higher reprogramming efficiency than PB-EPCs. Transcriptomic analysis using microarrays found a total of 1133 genes differentially expressed in CB-EPCs compared with PB-EPCs, with 675 genes upregulated and 458 downregulated. Several canonical pathways were impacted, among which the human embryonic stem cell pluripotency pathway was of particular interest. The differences in the gene expression pattern between CB-EPCs and PB-EPCs provide a molecular basis for the discrepancies seen in their derivation and reprogramming efficiencies, and highlight the advantages of using CB as the cellular source for the generation of iPSCs and their derivative tissues for ethnic-related toxicological applications.

  10. Comparative transcriptomic analysis of endothelial progenitor cells derived from umbilical cord blood and adult peripheral blood: Implications for the generation of induced pluripotent stem cells.

    Science.gov (United States)

    Gao, Xiugong; Yourick, Jeffrey J; Sprando, Robert L

    2017-12-01

    Induced pluripotent stem cells (iPSCs) offer the potential to generate tissues with ethnic diversity enabling toxicity testing on selected populations. Recently, it has been reported that endothelial progenitor cells (EPCs) derived from umbilical cord blood (CB) or adult peripheral blood (PB) afford a practical and efficient cellular substrate for iPSC generation. However, differences between EPCs from different blood sources have rarely been studied. In the current study, we derived EPCs from blood mononuclear cells (MNCs) and reprogrammed EPCs into iPSCs. We also explored differences between CB-EPCs and PB-EPCs at the molecular and cellular levels through a combination of transcriptomic analysis and cell biology techniques. EPC colonies in CB-MNCs emerged 5-7days earlier, were 3-fold higher in number, and consistently larger in size than in PB-MNCs. Similarly, iPSC colonies generated from CB-EPCs was 2.5-fold higher in number than from PB-EPCs, indicating CB-EPCs have a higher reprogramming efficiency than PB-EPCs. Transcriptomic analysis using microarrays found a total of 1133 genes differentially expressed in CB-EPCs compared with PB-EPCs, with 675 genes upregulated and 458 downregulated. Several canonical pathways were impacted, among which the human embryonic stem cell pluripotency pathway was of particular interest. The differences in the gene expression pattern between CB-EPCs and PB-EPCs provide a molecular basis for the discrepancies seen in their derivation and reprogramming efficiencies, and highlight the advantages of using CB as the cellular source for the generation of iPSCs and their derivative tissues for ethnic-related toxicological applications. Published by Elsevier B.V.

  11. Análisis de los resultados esperados de un proyecto de educación continua en la salud: efectos multiplicadores y cambios en el proceso de trabajo

    Directory of Open Access Journals (Sweden)

    Márcia Kafer MENDONÇA

    2011-04-01

    Full Text Available O objetivo deste trabalho é fazer uma análise dos resultados esperados de um projeto de Educação Permanente em Saúde intitulado “Atualização em Atenção Básica de Saúde”, desenvolvido por um Pólo Regional de Educação Permanente em Saúde do Estado do Paraná, no que se refere à multiplicação dos conteúdos pelos sujeitos que o realizaram para os demais profissionais do município e mudanças no processo de trabalho. Para tanto, realizou-se pesquisa de campo junto a 18 profissionais participantes do curso, por meio de questionário, sendo os dados coletados analisados a partir de uma abordagem quantitativa. No que concerne ao efeito multiplicador 78% dos sujeitos realizou o repasse de alguns conteúdos e os demais não o fizeram devido várias dificuldades a nível local; as mudanças no processo de trabalho se expressaram na organização do trabalho e técnica, melhora do conhecimento sobre o serviço e melhor desempenho profissional. Os resultados obtidos revelam que quando os participantes do curso conseguiram atuar como multiplicadores houve melhor organização no trabalho, melhor atendimento a população e trabalho em equipe. Deste modo, considera-se relevante ter nos serviços de saúde, um espaço coletivo de reflexão e ação para a constituição de sujeitos críticos, desenvolvimento de vínculos e a cooperação mútua, como é proposto pela educação permanente em saúde.

  12. Desarrollo rápido de software libre de alta calidad : Ingeniería de software asistida por computadora, enfocada en tareas, para agilizar el ciclo de vida de las aplicaciones, mediante mejora continua disciplinada a nivel personal

    OpenAIRE

    Reingart, Mariano A.

    2015-01-01

    El presente artículo resume el estudio, desarrollo e implementación de un marco de trabajo teórico/práctico para creación y mantenimiento ágil de software libre, orientado al desarrollo de aplicaciones empresariales centradas en datos (principalmente transaccionales, con bases de datos relacionales, lenguaje de programación dinámico e interfaces web y visuales). Se analiza el estado del arte respecto a proyectos libres y abiertos (producción por pares, fomento, motivación, diversidad, goberna...

  13. From 1962 the teaching of Methodology of Radioisotopes is continuous in the University of Buenos Aires of the Argentine Republic; Desde 1962 la ensenanza de Metodologia de Radioisotopos es continua en la Universidad de Buenos Aires de la Republica Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, E; Cremaschi, G; Martin, G; Zubillaga, M; Cricco, G; Davio, C; Genaro, A; Bianchin, A; Mohamad, N; Klecha, A; Calmanovici, G; Goldman, G; Salgueiro, J; Nunez, M; Medina, V; Gutierrez, A; Leonardi, N; Bergoc, R [Laboratorio de Radioisotopos, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, 1113- Buenos Aires (Argentina)

    2006-07-01

    In the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires the teaching of the radioisotopes began in 1960 and uninterruptedly continuous. The application of the radioisotopes and the radiations in different professional activities it is acceptable only in a context of radiological safety and with personal appropriately trained. Conscious of it, the training in grade, postgraduate and technicature, has more of 40% of the thematic one guided to the formation in radiological protection. The courses dictated at the moment in the Laboratory of Radioisotopes they include: Grade formation: to) Subject grade 'Methodology of Radioisotopes' in the Career of Biochemistry: it began to be dictated in 1960 and until the present, more of 6500 students they have gone by our classrooms. b) Grade subject 'Radiopharmacy' in the Career of Pharmacy: guided to the formation of a modern pharmacist, with necessary knowledge to be developed as professional in the Radiopharmaceutical area. Postgraduate formation: c) Postgraduate course of Methodology of Radioisotopes specially directed to biochemical, biologists, veterinarians, chemical. It is dictated uninterruptedly from 1962. d) Postgraduate course in Methodology of Radioisotopes for medical professionals, specially directed to professionals of the medicine that want to specialize in different branches of the Nuclear Medicine. Both courses have 220 present hours and it stops their approval the assistants they should surrender a final exam at open book that consists on the resolution of a practical exercise adapted to their professional practices. Until the present they have surrendered their exams satisfactorily approximately 2000 professionals coming from different areas of the Argentina and of several countries of Hispanic speech. e) Starting from 1992 the Course of Upgrade in Methodology of Radioisotopes directed to professionals that want to upgrade its knowledge in new radioisotopic methodologies is dictated. Formation of university extension: f) Methodology of Radioisotopes like Technicature. From 1962, the training of technicians was made parallel to that of professionals. From 1997 a Specific Course of Technicians in Nuclear Medicine is dictated, with an own curricular organization and chord to the basic formation of the assistants and its particular professional expectation. All the courses are credited by the Argentine Nuclear Regulatory Authority (ARN). The approval requires of a written exam and a colloquy in which the assistants demonstrate to be able to implement the measures of radiological protection in their labor environments. In their dictation participate professionals of the more high academic level (Ph.D.) and noted member specialists of the ARN. (Author)

  14. Evaluación y mejora continua de las medidas en prevención de riesgos laborales aplicadas en el Laboratorio de Metrología y Calibración Dimensional de la Universidad de Valladolid

    OpenAIRE

    Pascual Álvarez, Beatriz

    2017-01-01

    En el presente Trabajo Fin de Máster se realiza una evaluación de las medidas correctivas y preventivas implantadas en el Laboratorio de Metrología y Calibración Dimensional de la Universidad de Valladolid dos años después de la evaluación de riesgos que se realizó en sus instalaciones. También se proponen fichas de seguridad de dos puestos de trabajo con toda la documentación auxiliar que se cree oportuna. Estas actuaciones en materia de prevención son fruto de la filosofía de mejora continu...

  15. SOLUCIÓN ANALÍTICA PARA OBTENER EL VOLUMEN ÓPTIMO DE UNA SERIE DE REACTORES DE AGITACIÓN CONTINUA DONDE SE EFECTÚA UNA REACCIÓN DE PRIMER ORDEN

    Directory of Open Access Journals (Sweden)

    Ignacio Elizalde

    2013-01-01

    Full Text Available An analytical procedure for determining the optimum size of CSTR in series operating under isothermal and isobaric conditions sustaining first order reaction at constant density has been developed. The procedure requires the concentration of reactant at the entrance of the first reactor and at the outlet of the last reactor; it is also required the continuity of reaction rate as function of conversion, due to the later changes from one reactor to another. The optimization method involves the calculation of intermediate concentrations instead of their estimation, as it is done by graphical solution reported previously. Also, the procedure reported in this contribution is valid for any reactor number. Under these circumstances the method predicts that all reactors must have the same size in order to minimize the total volume of the system.

  16. Implementación de un sistema de gestión de personal orientado a la mejora continua de los procesos de producción en una fábrica de alimentos

    OpenAIRE

    Morales, J.; Barcia Villacreses, Kleber F.

    2009-01-01

    El manejo de la motivación, involucramiento y participación de las personas dentro de una fábrica o empresa es un tema que suele ser tratado de manera empírica, o en ocasiones simplemente no se tiene en consideración dentro de su organización. Por otro lado, es también evidente que en muchas industrias no existe un sistema estructurado de gestión de mejora y optimización de los recursos y procesos. El presente trabajo ilustra un caso exitoso de implementación en una fábrica de alimentos de un...

  17. Ensaios terapêuticos com penicilina: III - Bouba (Framboesia, pian, yaws: (continuação: penicilina de procedência americana, empregada em doses baixas também cura aparentemente esta enfermidade

    Directory of Open Access Journals (Sweden)

    A. M. da Cunha

    1944-10-01

    Full Text Available Five patients of yaws were treated with american Penicillin (Squibb, Winthrop and Lilly, in small dosis. The treatment has been performed, using 200 Oxford units each 4 hours. The total amount of units "per" subject, has varied from 24.000 to 54.000. A complete disappearence of the external lesions was obtained between the 12th and the 25th day of treatment.

  18. Conceptualización y reflexión sobre la práctica educativa en un programa de formación continua para docentes de educación media superior en México

    OpenAIRE

    Guadalupe Nancy Nava-Gómez; Jenaro Reynoso-Jaime

    2015-01-01

    El artículo expone un acercamiento a la conceptualización de la práctica educativa en un pro grama de posgrado en la Universidad Autónoma del Estado de México (UAEM). A partir de la diferencia entre programas educativos orientados a la profesionalización docente, se contextualiza la problemática sobre los programas actuales orientados a la formación de los docentes del nivel medio superior. El objetivo central del documento consiste en presentar experiencias pedagógicas de un programa de estu...

  19. A stochastic model for neutron simulation considering the spectrum and nuclear properties with continuous dependence of energy; Um modelo estocastico de simulacao neutronica considerando o espectro e propriedades nucleares com dependencia continua de energia

    Energy Technology Data Exchange (ETDEWEB)

    Camargo, Dayana Queiroz de

    2011-01-15

    This thesis has developed a stochastic model to simulate the neutrons transport in a heterogeneous environment, considering continuous neutron spectra and the nuclear properties with its continuous dependence on energy. This model was implemented using Monte Carlo method for the propagation of neutrons in different environment. Due to restrictions with respect to the number of neutrons that can be simulated in reasonable computational processing time introduced the variable control volume along the (pseudo-) periodic boundary conditions in order to overcome this problem. The choice of class physical Monte Carlo is due to the fact that it can decompose into simpler constituents the problem of solve a transport equation. The components may be treated separately, these are the propagation and interaction while respecting the laws of energy conservation and momentum, and the relationships that determine the probability of their interaction. We are aware of the fact that the problem approached in this thesis is far from being comparable to building a nuclear reactor, but this discussion the main target was to develop the Monte Carlo model, implement the code in a computer language that allows extensions of modular way. This study allowed a detailed analysis of the influence of energy on the neutron population and its impact on the life cycle of neutrons. From the results, even for a simple geometrical arrangement, we can conclude the need to consider the energy dependence, i.e. an spectral effective multiplication factor should be introduced each energy group separately. (author)

  20. Efecto del pastoreo sobre la resistencia mecánica del suelo en sistemas de producción bajo siembra directa continua Impact of cattle grazing on soil mechanical resistance in production systems under continuous no-till

    Directory of Open Access Journals (Sweden)

    Hugo R Krüger

    2008-12-01

    Full Text Available Los objetivos del estudio fueron: a caracterizar la variación de la resistencia mecánica a la penetración (RST de la capa de suelo de 0 a 20 cm en dos rotaciones con y sin pastoreo directo y b establecer su relación con el contenido de agua del suelo (W. El estudio se realizó sobre un Hapludol típico del sudoeste de la provincia de Buenos Aires, sobre secuencias basadas en girasol y trigo. Se estudiaron dos tratamientos: a Agrícola, que no incluyó pastoreo y b Mixta que incorporó un cultivo de avena pastoreado por novillos de 350 a 400 kg (25 cabezas/ha previo al girasol. Se determinaron RST y W en diez fechas de muestreo. Luego del pastoreo de avena, la RST de Mixta fue mayor que la de Agrícola en toda la capa, con picos en 2,5-7,5 cm. Ajustada a un W de 190 g kg-1, la RST de Agrícola mostró una tendencia lineal ligeramente creciente en el tiempo; la RST Mixta ajustó a un modelo cuadrático con tendencia a estabilizarse en valores cercanos a 2,5 MPa. Mixta presentó además un segundo nivel de variación relacionado con las fechas de muestreo: la RST luego del pastoreo de avena fue mayor que al final del ciclo avena-girasol-trigo. La disminución se atribuyó a una recuperación de la bioporosidad por efecto de las raíces de los cultivos. Las RST observadas fueron cercanas o mayores a las críticas para la penetración de las raíces en el 20 y 50% de las fechas de muestreo para Agrícola y Mixta, respectivamente.The objectives of this study, were: a to characterize the soil mechanical penetration resistance (RST variation in the 0 to 20 -cm depth of two rotation treatments with and without cattle grazing and b to determine the RST relationship with soil water content (W. The experiment took place on a Typic Haplustoll in SW Buenos Aires province, on sunflower-wheat based rotations. Treatments included: a 100 % cash-crop rotation with no cattle grazing and b Mixed rotation, including an oat forage crop with direct grazing by 350 to 400 kg steer at a 25 head/ha stocking rate between wheat and sunflower crops. RST and W were determined on ten opportunities near planting dates. After oat grazing, RST was higher in the Mixed rotation compared to the crop rotation in the 0 to 20 cm soil layer, with greater differences in the 2.5-7.5 cm layer. Corrected to a W of 190 g kg-1, the RST in the crop rotation showed an increasing linear trend over time. RST for the mixed rotation fitted a quadratic model which tended to stabilize at 2.5 MPa. In addition, the mixed rotation showed a second variation pattern related to sample dates: RST after grazed oats was higher than at the end of the oat-sunflower-wheat cycle. This decrease was attributed to a recovery of bioporosity due to the crop roots effect on the soil. Observed RST values were close or higher than those considered critical for root penetration in 20 and 50% of sampling dates for the crop and mixed rotations, respectively.

  1. Hidratación oral continua o a dosis fraccionadas en niños deshidratados por diarrea aguda Oral rehydration in continuous administration or in fractionated doses in dehydrated children with acute diarrhea

    Directory of Open Access Journals (Sweden)

    Felipe Mota-Hernández

    2002-01-01

    Full Text Available Objetivo. Evaluar la seguridad y efectividad de dos técnicas de hidratación oral. Material y métodos. Ensayo clínico aleatorio, hecho en el Servicio de Hidratación Oral del Hospital Infantil de México, Federico Gómez, entre septiembre de 1998 y junio de 1999. Cuarenta pacientes deshidratados por diarrea aguda, menores de cinco años, recibieron suero oral ad libitum (grupo AL y otros cuarenta lo recibieron en dosis fraccionada (grupo DF. Las características clínicas fueron similares en ambos grupos. Los resultados se presentan como promedio y desviación estándar o mediana, según la distribución de frecuencias simples y relativas. Resultados. El promedio de gasto fecal en el grupo AL fue 11.0±7.5 g/kg/h y en el grupo DF 7.1±7.4 (p=0.03. La ingesta de suero, el tiempo de hidratación y la diuresis promedio, fueron similares entre ambos grupos (p>0.05. Seis pacientes del grupo AL y cinco del DF tuvieron gasto fecal alto (>10 g/kg/hora, mejorando con la administración de atole de arroz. Un paciente del grupo AL y dos pacientes del DF tuvieron vómitos persistentes, mejorando con gastroclisis. Ningún paciente requirió rehidratación intravenosa. Conclusiones. Estos resultados sugieren que la administración de suero oral ad libitum, bajo supervisión, es tan segura y efectiva como la técnica de dosis fraccionada para el tratamiento de niños deshidratados por diarrea aguda.Objective. To evaluate the safety and effectiveness of two oral rehydration techniques. Material and Methods. A randomized clinical trial was conducted at the oral rehydration unit of Hospital Infantil de Mexico "Federico Gomez", between September 1998 and June 1999. Forty patients five-year old and younger children, dehydrated due to acute diarrhea, were given oral rehydration solution (ORS ad libitum (AL group; another forty patients received ORS in fractionated doses (FD group. Clinical characteristics were similar in both groups. Results are presented as means, standard deviations and medians, according the distribution of simple and relative frequencies. Results. The mean stool output in the AL group was 11.0±7.5 g/kg/h; as compared to 7.1±7.4 in the FD group (p=0.03. ORS intake, rehydration time, and mean diuresis values were similar in both groups (p>0.05. Six patients in the AL group and five in the FD group had high stool output (>10 g/kg/h, that improved after administration of rice starch solution. One patient in the AL group and two in the FD group had persistent vomiting that improved with gastroclisis. No patient required intravenous rehydration. Conclusions. These results suggest that ORS administration ad libitum under supervision, is a technique as safe and effective as the fractionated doses technique, for the treatment of dehydrated children due to acute diarrhea.

  2. Use of the Regenerative Braking of Suburban Trains for Fast DC Charging of Electric Cars; Utilizacion del frenado regenerativo de trenes suburbanos para la recarga rapida de automoviles electricos en corriente continua

    Energy Technology Data Exchange (ETDEWEB)

    Lafoz, M.; Concha, P.; Navarro, G.; Blanco, M.; Rodriguez, C.

    2014-04-01

    This article discusses the problem of the electric vehicles fast charge from the perspective of the need for a high voltage power supply in areas where it is hard to access power transmission infrastructures, and how this problem can be solved with a system based on the supply of power from suburban train lines, together with energy storage systems and where everything is governed by optimized control strategies to maximize the energy use as much as possible. (Author)

  3. Sentirse apoyado: Experiencia de pacientes en Ventilación Mecánica sin efectos de sedación continua To feel leaning: Experience of patient in mechanical ventilation without continuous sedation effects

    Directory of Open Access Journals (Sweden)

    Ángela María Henao Castaño

    2010-09-01

    Full Text Available Objetivo: Describir los mecanismos de afrontamiento utilizados por los pacientes que se encuentran sometidos a ventilación mecánica sin efectos de sedación continúa en una UCI. Metodología: se realizó una investigación con enfoque fenomenológico que contó con la participación de siete hombres y dos mujeres con edades entre 24 y 75 años. La técnica de recolección de la información fue la entrevista a profundidad. Resultados: "Sentirse apoyado y magnificar la espiritualidad", estar críticamente enfermo hace que se vivan situaciones de sufrimiento y soledad, convirtiendo a la familia y a la creencia religiosa como partes del proceso de recuperación. Conclusión: vivir la experiencia de la ventilación mecánica sin efectos de sedación fue para los participantes trascendental debido a que percibieron durante su proceso de enfermedad el apoyo que la familia y la creencia religiosa les brindó para poder recuperarse; la familia son personas que dan palabras de aliento, brindan ayuda emocional y espiritual.Objective: to describe the confrontation mechanisms used by the patients that are subjected to mechanical ventilation without effects of continues sedation in an ICU. Methodology: it was carried out an investigation with phenomelogycal focus that had the participation of seven men and two women between 24 and 75 years old. The technique of gathering of the information was the interview in depth. Results: "to feel leaning and to magnify the spirituality". To be critically sick makes that situations of suffering and solitude been lived, converting the family and religious belief as parts of the recovery process. Conclusion: to live the experience of the mechanical ventilation without sedation effects was for the participants deeply significant because they perceived during their illness the support that the family and the religious belief offer them to be able to recover; the family is people that give words of encouragement, they offer emotional and spiritual help.

  4. Experiences in the continuous improvement of quality assurance of the dosimetry services of SLDC-MD-ININ; Experiencias en la mejora continua del aseguramiento de la calidad de los servicios de dosimetria de LSCD-ME-ININ

    Energy Technology Data Exchange (ETDEWEB)

    Tovar M, V. M.; Vergara M, F.; Perez M, V.; Anaya M, R.; Cejudo A, J.; Alvarez R, J. T.; Arenas O, A.; Cruz F, C., E-mail: victor.tovar@inin.gob.m [ININ, Departamento de Metrologia de Radiaciones Ionizantes, Laboratorio Secundario de Calibracion Dosimetrica, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-09-15

    From 2003 the Secondary Laboratory of Dosimetric Calibration (SLDC) of Metrology Department of Ionizing Radiations (MD), has complemented the Quality Manual of National Institute of Nuclear Research (ININ) according to the standard ISO 9001: 2000. However, due to that the National Center of Metrology of Mexico delegates its functions in the dosimetry and activity area for the field of the ionizing radiations to the ININ: one of the requirements so that the ININ has been designated as -Declared Institute- before the International Office of Weights and Measurements, it is to demonstrate before the Inter-American System of Metrology that the quality system of the SLDC fulfills the standard ISO/IEC 17025: 2005, satisfied this requirement the Inter-American System of Metrology in their meeting of evaluation of quality systems, Ottawa (2007) grants a certification document to the SLDC that guarantees their capacities of calibration measurements for dosimetry services. Concretely, inside the standard activities ISO 9000 with respect to the point 8 on measurement, analysis and improvement the Management of Quality Assurance of ININ carries out at year two interns auditing and every month is given continuation to the non conformities detected in the procedures that support the services of the SLDC for dosimetry with purposes of radiological protection and clinical dosimetry. (Author)

  5. Aplicación de metodologías y herramientas estadísticas para el análisis de encuestas de satisfacción como base para la mejora continua en una empresa del sector textil

    OpenAIRE

    ESTÍBALEZ PIÑANA, RAQUEL

    2015-01-01

    [ES] La calidad se ha convertido en un factor clave para determinar el éxito o fracaso de una empresa en el mercado mundial. En el actual contexto económico caracterizado por la saturación de los mercados de países desarrollados, la calidad es un elemento básico en la estrategia empresarial y un elemento determinante de la elección de los consumidores. La evaluación de la satisfacción de los usuarios de una organización es una de las herramientas fundamentales para medir la calidad de los pro...

  6. Indicators of the management for the continuous improvement of the radiological safety in a radioactive facility; Indicadores de gestion para la mejora continua de la seguridad radiologica en una instalacion radiactiva

    Energy Technology Data Exchange (ETDEWEB)

    Amador B, Z. H. [Centro de Isotopos, Ave. Monumental y Carretera La Rada, Km 3, Guanabacoa, Apartado 3415, Ciudad de La Habana (Cuba)]. e-mail: zabalbona@centis.edu.cu

    2006-07-01

    The use of safety indicators is common in the nuclear industry. In this work the implementation of indicators for the efficiency analysis of the radiological safety management system of a radioactive installation is presented. Through the same ones the occupational exposure, the training Y authorization of the personnel, the control of practices Y radioactive inventory, the results of the radiological surveillance, the occurrence of radiological events, the aptitude of the monitoring equipment, the management of the radioactive waste, the public exposure, the audits Y the costs of safety are evaluated. Its study is included in the periodic training of the workers. Without this interrelation it is not possible to maintain the optimization of the safety neither to achieve a continuous improvement. (Author)

  7. From 1962 the teaching of Methodology of Radioisotopes is continuous in the University of Buenos Aires of the Argentine Republic; Desde 1962 la ensenanza de Metodologia de Radioisotopos es continua en la Universidad de Buenos Aires de la Republica Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, E.; Cremaschi, G.; Martin, G.; Zubillaga, M.; Cricco, G.; Davio, C.; Genaro, A.; Bianchin, A.; Mohamad, N.; Klecha, A.; Calmanovici, G.; Goldman, G.; Salgueiro, J.; Nunez, M.; Medina, V.; Gutierrez, A.; Leonardi, N.; Bergoc, R. [Laboratorio de Radioisotopos, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, 1113- Buenos Aires (Argentina)]. e-mail: rmbergoc@arnet.com.ar

    2006-07-01

    In the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires the teaching of the radioisotopes began in 1960 and uninterruptedly continuous. The application of the radioisotopes and the radiations in different professional activities it is acceptable only in a context of radiological safety and with personal appropriately trained. Conscious of it, the training in grade, postgraduate and technicature, has more of 40% of the thematic one guided to the formation in radiological protection. The courses dictated at the moment in the Laboratory of Radioisotopes they include: Grade formation: to) Subject grade 'Methodology of Radioisotopes' in the Career of Biochemistry: it began to be dictated in 1960 and until the present, more of 6500 students they have gone by our classrooms. b) Grade subject 'Radiopharmacy' in the Career of Pharmacy: guided to the formation of a modern pharmacist, with necessary knowledge to be developed as professional in the Radiopharmaceutical area. Postgraduate formation: c) Postgraduate course of Methodology of Radioisotopes specially directed to biochemical, biologists, veterinarians, chemical. It is dictated uninterruptedly from 1962. d) Postgraduate course in Methodology of Radioisotopes for medical professionals, specially directed to professionals of the medicine that want to specialize in different branches of the Nuclear Medicine. Both courses have 220 present hours and it stops their approval the assistants they should surrender a final exam at open book that consists on the resolution of a practical exercise adapted to their professional practices. Until the present they have surrendered their exams satisfactorily approximately 2000 professionals coming from different areas of the Argentina and of several countries of Hispanic speech. e) Starting from 1992 the Course of Upgrade in Methodology of Radioisotopes directed to professionals that want to upgrade its knowledge in new radioisotopic methodologies is dictated. Formation of university extension: f) Methodology of Radioisotopes like Technicature. From 1962, the training of technicians was made parallel to that of professionals. From 1997 a Specific Course of Technicians in Nuclear Medicine is dictated, with an own curricular organization and chord to the basic formation of the assistants and its particular professional expectation. All the courses are credited by the Argentine Nuclear Regulatory Authority (ARN). The approval requires of a written exam and a colloquy in which the assistants demonstrate to be able to implement the measures of radiological protection in their labor environments. In their dictation participate professionals of the more high academic level (Ph.D.) and noted member specialists of the ARN. (Author)

  8. Análisis de consistencia de caminos bidireccionales usando mediciones continuas de velocidad de operación obtenidas con GPS Two-lane rural highways consistency analysis using continuous operating speed measurements obtained with GPS

    Directory of Open Access Journals (Sweden)

    Tomás Echaveguren

    2012-08-01

    Full Text Available El análisis de consistencia permite evaluar la seguridad en caminos en base a la velocidad. Existen diversos modelos velocidad - geometría para elementos aislados de una carretera, que se utilizan para evaluar la consistencia de elementos aislados del trazado de una carretera. Por ejemplo curvas horizontales simples o en curvas de inflexión en "S".Los modelos de análisis de consistencia agregados, permiten evaluar segmentos largos de trazado, por lo que necesitan perfiles de velocidad continuos. En este caso, los modelos y mediciones puntuales de velocidad no son adecuados. Actualmente, la tecnología de posicionamiento satelital es una manera eficiente de construir perfiles de velocidad en largas distancias del trazado, siendo particularment útil para aplicar el método de Polus. Este trabajo estudia el modelo de análisis de consistencia de Polus usando perfiles continuos de velocidad. Primero se discute dicho modelo, para luego presentar la obtención y tratamiento de datos de velocidad usando modelos y mediciones directas. El método se aplicó a 5 casos de estudio en los cual se midió en terreno la velocidad y geometría con un GPS partir del cual se obtuvieron perfiles directos y teóricos de velocidad .Los datos fueron procesados con el filtro de Kalman y suavizados con el método LOESS, para luego evaluar la consistencia de cada ruta. Se concluyó que el método de Polus y los perfiles contínuos de velocidad medidos permiten obtener una calificación de segmentos largos del trazado, pero se debe segmentar adecuadamente cada trazado para evitar sub/sobre estimaciones de consistencia.Consistency assessment permits to study road safety regarded to speed. There exist several speed-geometry models that assessed isolated components of roads, which are used for consistency assessment of single elements of roads. For instance, single horizontal curves or reverse curves. Aggregated consistency assessment models, permit to assess long segments of roads.Therefore, continuous speed profiles are needed. In that case, speed-geometry models for single elements are not suitable. Today satellite positioning technology is an efficient way to develop continuous speed profile for long sectors of roads, particularly useful for aggregated consistency assessement. This paper study the Polus' consistency assesment model, which need as input continuous speed profiles. First, Polus' model is discussed. After a method for speed data collection and processing using in-field measurements and models is discussed. Method was applied to 5 roads using a GPS device. Data were processed with Kalman filter and smoothed with loess smoother. With the speed profile processed, filtered and smoothed, Polus' consistency method was used to estimate consistency index in each road. It was concluded that Polus' method and continuous speed profiles are suitables to rate consistency of long road segments. However, special attention should be given to road segmentation to avoid under or over-estimation of the road consistency, particularly in straight and steeped segments.

  9. FORMACIÓN CONTINUA DE LOS DOCENTES DE LA INSTITUCIÓN EDUCATIVA “SAN LUIS GONZAGA FE Y ALEGRÍA 22”, PARA MEJORAR, EL TRABAJO EN EQUIPO Y LA CALIDAD EDUCATIVA

    OpenAIRE

    Alarcón Zamora, José Presvítero; Fé y Alegría; Chávarry Ysla, Patricia del Rocio; Universidad Señor de Sipán

    2015-01-01

    Hoy en día, en la práctica, encontramos comunidades educativas desmotivadas, desorganizadas y  conflictivas que actúan sin ninguna planificación, no hay un trabajo en equipo, no existe buenas relaciones humanas. En conclusión falta identidad y ética. El problema que se aborda esta centrado en analizar la carencia de una política de formación docente continúa a nivel de las instituciones educativas que puedan responder a la demanda educativa de los docentes. En la Insti

  10. Ground failure in direct current systems of the Itaipu Hydroelectric Power Plant, Parana, Brazil. Impact in the operation; Falla a tierra en sistemas de corriente continua en la Central Hidroelectrica Itaipu, PR, Brasil. Impacto en la operacion

    Energy Technology Data Exchange (ETDEWEB)

    Soto Santacruz, Heriberto [Itaipu Binacional, Foz do Iguacu, PR (Brazil)]. E-mail: soto@itaipu.gov.py

    1998-07-01

    The objective of this work is to share with other companies the operation experience obtained by researching the direct current systems ground failure, in the Itaipu Hydroelectric Power Plant. During the research process electrical and/or electronic components can be damaged, and also human failures can occurred during the circuit connection and disconnection manoeuvres, necessary for the identification of the components causing the failures.

  11. La ética como contenido transversal de la educación médica continua y su formación docente específica

    OpenAIRE

    Susacasa, Sandra; Candreva, Anna

    2016-01-01

    Los datos, a nivel internacional, muestran que los programas de promoción de salud no fueron suficientes para responder a la propuesta de la OMS para el año 2000. Aceptando la complejidad del análisis de sus causas sí es evidente que emerge una dimensión que adquiere relevancia: la formación de los profesionales de la salud, en particular la Médica, a quienes se les reconoce la función social de instalar el cuidado, preservación, prevención y recuperación de la salud, acreditándoles competenc...

  12. Computer program for allocation of generators in isolated systems of direct current using genetic algorithm; Programa computacional para alocacao de geradores em sistemas isolados de corrente continua utilizando algoritmo genetico

    Energy Technology Data Exchange (ETDEWEB)

    Gewehr, Diego N.; Vargas, Ricardo B.; Melo, Eduardo D. de; Paschoareli Junior, Dionizio [Universidade Estadual Paulista (DEE/UNESP), Ilha Solteira, SP (Brazil). Dept. de Engenharia Eletrica. Grupo de Pesquisa em Fontes Alternativas e Aproveitamento de Energia

    2008-07-01

    This paper presents a methodology for electric power sources location in isolated direct current micro grids, using genetic algorithm. In this work, photovoltaic panels are considered, although the methodology can be extended for any kind of DC sources. A computational tool is developed using the Matlab simulator, to obtain the best dc system configuration for reduction of panels quantity and costs, and to improve the system performance. (author)

  13. The importance of Thermo-Hydro-Mechanical couplings and microstructure to strain localization in 3D continua with application to seismic faults. Part II: Numerical implementation and post-bifurcation analysis

    Science.gov (United States)

    Rattez, Hadrien; Stefanou, Ioannis; Sulem, Jean; Veveakis, Manolis; Poulet, Thomas

    2018-06-01

    In this paper we study the phenomenon of localization of deformation in fault gouges during seismic slip. This process is of key importance to understand frictional heating and energy budget during an earthquake. A infinite layer of fault gouge is modeled as a Cosserat continuum taking into account Thermo-Hydro-Mechanical (THM) couplings. The theoretical aspects of the problem are presented in the companion paper (Rattez et al., 2017a), together with a linear stability analysis to determine the conditions of localization and estimate the shear band thickness. In this Part II of the study, we investigate the post-bifurcation evolution of the system by integrating numerically the full system of non-linear equations using the method of Finite Elements. The problem is formulated in the framework of Cosserat theory. It enables to introduce information about the microstructure of the material in the constitutive equations and to regularize the mathematical problem in the post-localization regime. We emphasize the influence of the size of the microstructure and of the softening law on the material response and the strain localization process. The weakening effect of pore fluid thermal pressurization induced by shear heating is examined and quantified. It enhances the weakening process and contributes to the narrowing of shear band thickness. Moreover, due to THM couplings an apparent rate-dependency is observed, even for rate-independent material behavior. Finally, comparisons show that when the perturbed field of shear deformation dominates, the estimation of the shear band thickness obtained from linear stability analysis differs from the one obtained from the finite element computations, demonstrating the importance of post-localization numerical simulations.

  14. LINKCARE, realització d'una plataforma de telemedicina experimental per la monitorització continua de malalts crònics de l'Hospital Clínic de Barcelona

    OpenAIRE

    Álvarez Baldó, Andrea

    2010-01-01

    LINKARE es una plataforma de Telemedicina experimental. La primera fase del proyecto está diseñada y desarrollada. Los trabajos a realizar consisten en la implantación de la plataforma LINKCARE en un entorno real, inicialmente de preproducción y posteriromente de producción, en el Hospital Clínic, por ello el proyecto se desarrollará en esta institución.

  15. Nine years of charcoal continuous sintering in Belgo-Mineira Iron and Steel Company (BMISC); Nove anos de operacao da sinterizacao continua a carvao vegetal da Companhia Siderurgica Belgo Mineira (CSBM)

    Energy Technology Data Exchange (ETDEWEB)

    Mines, Claude Rene Camille; Lamas, Vicente Paulo Barroso; Junqueira, Sergio Almeida; Castro, Riolando de Souza; Vital, Raimundo Geraldo; Vieira, Nelson [Companhia Siderurgica Belgo Mineira, Joao Monlevade, MG (Brazil)

    1988-12-31

    The principal data of the continuous sintering plant from Belgo Mineira Iron and Steel Company, Brazil, are shown. The evolution of data and the operational procedures to obtain them are discussed. The procedures to improve data are also described. (author) 1 ref., 6 figs., 2 tabs.

  16. Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients.

    Science.gov (United States)

    Thomas, H E; Parry, G; Dark, J H; Arthur, H M; Keavney, B D

    2009-02-01

    Increasing age is associated with reduced numbers of circulating endothelial progenitor cells (EPCs). It is unclear whether this relates to depletion or impairment of bone marrow progenitors, or to deficient mobilization signals from aging tissues. In cardiac transplant patients, one previous study has reported an association between circulating EPCs and the risk of cardiac allograft vasculopathy (CAV). We investigated whether increased donor heart age, a strong risk factor for CAV, was associated with reduced circulating EPC numbers in a group of cardiac transplant recipients matched for factors which influence EPC numbers, but with maximally discordant donor heart ages. We identified 32 patient pairs, matched for factors known to influence EPC numbers, but who had discordant donor heart ages by at least 20 years. EPCs were quantified using flow cytometry for absolute counts of cells expressing all the combinations of CD45, CD34, CD133 and the kinase domain receptor (KDR). There were no significant differences in the numbers of circulating EPCs between patients with old or young donor heart age. There was no association between the presence of CAV and circulating EPC numbers. We suggest that the increased susceptibility to CAV of older donor hearts is not mediated via circulating EPCs. Our results are consistent with the theory that the normal age-related decline in EPC numbers relates to bone marrow aging rather than failure of target tissues to induce EPC mobilization.

  17. Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development.

    Science.gov (United States)

    Abd El Aziz, M T; Abd El Nabi, E A; Abd El Hamid, M; Sabry, D; Atta, H M; Rahed, L A; Shamaa, A; Mahfouz, S; Taha, F M; Elrefaay, S; Gharib, D M; Elsetohy, Khaled A

    2015-03-01

    We achieved possibility of isolation, characterization human umbilical cord blood endothelial progenitor cells (EPCs), examination potency of EPCs to form new blood vessels and differentiation into cardiomyoctes in canines with acute myocardial infarction (AMI). EPCs were separated and cultured from umbilical cord blood. Their phenotypes were confirmed by uptake of double stains dioctadecyl tetramethylindocarbocyanine-labeled acetylated LDL and FITC-labeled Ulex europaeus agglutinin 1 (DILDL-UEA-1). EPCs of cord blood were counted. Human VEGFR-2 and eNOS from the cultured EPCs were assessed by qPCR. Human EPCs was transplanted intramyocardially in canines with AMI. ECG and cardiac enzymes (CK-MB and Troponin I) were measured to assess severity of cellular damage. Histopathology was done to assess neovascularisation. Immunostaining was done to detect EPCs transdifferentiation into cardiomyocytes in peri-infarct cardiac tissue. qPCR for human genes (hVEGFR-2, and eNOS) was done to assess homing and angiogenic function of transplanted EPCs. Cultured human cord blood exhibited an increased number of EPCs and significant high expression of hVEGFR-2 and eNOS genes in the culture cells. Histopathology showed increased neovascularization and immunostaining showed presence of EPCs newly differentiated into cardiomyocyte-like cells. Our findings suggested that hEPCs can mediate angiogenesis and differentiate into cardiomyoctes in canines with AMI.

  18. Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development

    Directory of Open Access Journals (Sweden)

    M.T. Abd El Aziz

    2015-03-01

    Full Text Available We achieved possibility of isolation, characterization human umbilical cord blood endothelial progenitor cells (EPCs, examination potency of EPCs to form new blood vessels and differentiation into cardiomyoctes in canines with acute myocardial infarction (AMI. EPCs were separated and cultured from umbilical cord blood. Their phenotypes were confirmed by uptake of double stains dioctadecyl tetramethylindocarbocyanine-labeled acetylated LDL and FITC-labeled Ulex europaeus agglutinin 1 (DILDL-UEA-1. EPCs of cord blood were counted. Human VEGFR-2 and eNOS from the cultured EPCs were assessed by qPCR. Human EPCs was transplanted intramyocardially in canines with AMI. ECG and cardiac enzymes (CK-MB and Troponin I were measured to assess severity of cellular damage. Histopathology was done to assess neovascularisation. Immunostaining was done to detect EPCs transdifferentiation into cardiomyocytes in peri-infarct cardiac tissue. qPCR for human genes (hVEGFR-2, and eNOS was done to assess homing and angiogenic function of transplanted EPCs. Cultured human cord blood exhibited an increased number of EPCs and significant high expression of hVEGFR-2 and eNOS genes in the culture cells. Histopathology showed increased neovascularization and immunostaining showed presence of EPCs newly differentiated into cardiomyocyte-like cells. Our findings suggested that hEPCs can mediate angiogenesis and differentiate into cardiomyoctes in canines with AMI.

  19. MicroRNA-126 Priming Enhances Functions of Endothelial Progenitor Cells under Physiological and Hypoxic Conditions and Their Therapeutic Efficacy in Cerebral Ischemic Damage

    Directory of Open Access Journals (Sweden)

    Qunwen Pan

    2018-01-01

    Full Text Available Endothelial progenitor cells (EPCs have shown the potential for treating ischemic stroke (IS, while microRNA-126 (miR-126 is reported to have beneficial effects on endothelial function and angiogenesis. In this study, we investigated the effects of miR-126 overexpression on EPCs and explore the efficacy of miR-126-primed EPCs (EPCmiR-126 in treating IS. The effects of miR-126 overexpression on EPC proliferation, migratory, tube formation capacity, reactive oxygen species (ROS production, and nitric oxide (NO generation were determined. In in vivo study, the effects of EPCmiR-126 on the cerebral blood flow (CBF, neurological deficit score (NDS, infarct volume, cerebral microvascular density (cMVD, and angiogenesis were determined. Moreover, the levels of circulating EPCs (cEPCs and their contained miR-126 were measured. We found (1 miR-126 overexpression promoted the proliferation, migration, and tube formation abilities of EPCs; decreased ROS; and increased NO production of EPCs via activation of PI3K/Akt/eNOS pathway; (2 EPCmiR-126 was more effective than EPCs in attenuating infarct volume and NDS and enhancing cMVD, CBF, and angiogenesis; and (3 infusion of EPCmiR-126 increased the number and the level of miR-126 in cEPCs. Our data indicate that miR-126 overexpression enhanced the function of EPCs in vitro and in vivo.

  20. Exercise training-induced different improvement profile of endothelial progenitor cells function in mice with or without myocardial infarction.

    Science.gov (United States)

    Guo, Yuan; Peng, Ran; Liu, Qiong; Xu, Danyan

    2016-10-15

    Neovascularization in response to ischemia after myocardial infarction (MI) has been widely considered as being initiated by endothelial progenitor cells (EPCs). Well-documented evidences in recent years have proved exercise training (ET) improving EPC function. However, whether ET-induced improvement of EPC function under or without ischemic state is different has not been reported. Mice performed ET following an exercise prescription 1week after MI or non-MI surgery respectively. Bone marrow-derived EPCs were isolated at 0day, 3days, 1week, 2weeks, 4weeks, and 8weeks of ET. After 7days cultivation, EPC functions including proliferation, adhesion, migration, and in vitro angiogenesis were measured. AKT/glycogen synthase kinase 3β (GSK3β) signaling pathway was tested by western blotting. EPC function in mice underwent non-MI surgery was attenuated overtime, while ET ameliorated this tendency. EPC function was peaked at 4weeks ET in non-MI surgery mice and maintained with an extended exercise time. Besides, simple ischemia was sufficient to enhanced EPC function, with a maximum at 2weeks of MI surgery. In MI mice, ET further improved EPC function and achieved peak at 2weeks exercise. Furthermore, AKT/GSK3β signaling pathway activation was consistent with EPC function change after ischemia, which was further promoted by 4weeks exercise. ET significantly increased EPC function in mice both with and without MI, but the time points of peak function were different. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. An In Vitro Study of Differentiation of Hematopoietic Cells to Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Qi Ru Wang

    2011-01-01

    medium (ECCM. BM-EPCs were characterized in terms of phenotype, lineage potential, and their functional properties. Endothelial cell colonies derived from BM-EPC were cultured with ECCM for 3 months. Cultured EPC colony cells expressed endothelial cell markers and formed the capillary-like network in vitro. EPC colony cells expressed differential proliferative capacity; some of the colonies exhibited a high proliferative potential (HPP capacity up to 20 population doublings. More importantly, these HPP-EPCs expressed hematopoietic marker CD45, exhibited endocytic activities, and preserved some of the myeloid cell activity. In addition, the HPP-EPCs secrete various growth factors including VEGF and GM-CSF into the culture medium. The results demonstrate that these EPCs were primarily derived from hematopoietic origin of early precursor cells and maintained high proliferative potential capacity, a feature with a significant potential in the application of cell therapy in ischemic diseases.

  2. Safety profile and long-term engraftment of human CD31+ blood progenitors in bone tissue engineering.

    Science.gov (United States)

    Zigdon-Giladi, Hadar; Elimelech, Rina; Michaeli-Geller, Gal; Rudich, Utai; Machtei, Eli E

    2017-07-01

    Endothelial progenitor cells (EPCs) participate in angiogenesis and induce favorable micro-environments for tissue regeneration. The efficacy of EPCs in regenerative medicine is extensively studied; however, their safety profile remains unknown. Therefore, our aims were to evaluate the safety profile of human peripheral blood-derived EPCs (hEPCs) and to assess the long-term efficacy of hEPCs in bone tissue engineering. hEPCs were isolated from peripheral blood, cultured and characterized. β tricalcium phosphate scaffold (βTCP, control) or 10 6 hEPCs loaded onto βTCP were transplanted in a nude rat calvaria model. New bone formation and blood vessel density were analyzed using histomorphometry and micro-computed tomography (CT). Safety of hEPCs using karyotype analysis, tumorigenecity and biodistribution to target organs was evaluated. On the cellular level, hEPCs retained their karyotype during cell expansion (seven passages). Five months following local hEPC transplantation, on the tissue and organ level, no inflammatory reaction or dysplastic change was evident at the transplanted site or in distant organs. Direct engraftment was evident as CD31 human antigens were detected lining vessel walls in the transplanted site. In distant organs human antigens were absent, negating biodistribution. Bone area fraction and bone height were doubled by hEPC transplantation without affecting mineral density and bone architecture. Additionally, local transplantation of hEPCs increased blood vessel density by nine-fold. Local transplantation of hEPCs showed a positive safety profile. Furthermore, enhanced angiogenesis and osteogenesis without mineral density change was found. These results bring us one step closer to first-in-human trials using hEPCs for bone regeneration. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  3. Hyperglycemia and oxidized-LDL exert a deleterious effect on endothelial progenitor cell migration in type 2 diabetes mellitus.

    Science.gov (United States)

    Hamed, Saher; Brenner, Benjamin; Abassi, Zaid; Aharon, Anat; Daoud, Deeb; Roguin, Ariel

    2010-09-01

    Type 2 diabetes mellitus (DM) patients with coronary artery disease (CAD) have elevated plasma oxidized-LDL (OxLDL) levels and impaired neovascularization. Hyperglycemia and hyperlipidemia impair endothelial progenitor cell (EPC) migration, and endothelial nitric oxide (NO) bioavailability and NO synthase (NOS) activity are essential for EPC migration. Stromal-derived factor-1alpha (SDF1alpha) contributes to EPC mobilization and homing by stimulating the CXC receptor-4 (CXCR4) on the EPC plasmalemma to activate the Pi3K/Akt/eNOS signaling pathway. Therefore, we investigated the effect of high glucose (HG) and OxLDL on the migration and NO bioavailability of EPCs from healthy individuals, and then correlated the findings with those of EPCs from type 2 DM patients with and without CAD. EPCs from 15 healthy and 55 patients were exposed to HG, OxLDL, or both before evaluating EPC count, migration and NO production, and expression of CXCR4 and members of Pi3K/Akt/eNOS signaling cascade. Counts, migration, CXCR4 expression, and NO production were significantly reduced in EPCs from DM and CAD patients compared with that obtained in EPCs from healthy, and were further reduced in DM patients with CAD. The expression of CXCR4 and activation of Pi3K/Akt/eNOS signaling cascade were suppressed in OxLDL- and HG-treated EPCs, and this suppression was exacerbated when EPCs were treated simultaneously with HG and OxLDL. Hyperglycemia and elevated circulating OxLDL in DM patients with CAD severely impair EPC migration. These results suggest that the underlying mechanism for this impaired EPC migration is linked to the CXCR4/Pi3K/Akt/eNOS signaling pathway. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  4. Schlafen 1 inhibits the proliferation and tube formation of endothelial progenitor cells.

    Directory of Open Access Journals (Sweden)

    Chun-yan Kuang

    Full Text Available Endothelial progenitor cells (EPCs are the major source of cells that restore the endothelium during reendothelialization. This study was designed to investigate whether Schlafen 1 (Slfn1 has an effect on the proliferation and tube formation of EPCs in vivo. Slfn1 was expressed in rat EPCs. The overexpression of Slfn1 suppressed the proliferation and tube formation of EPCs; conversely, the knockdown of Slfn1 by shRNA promoted the proliferation and tube formation of EPCs. Furthermore, when Slfn1 was overexpressed, the EPCs were arrested in the G1 phase of the cell cycle. In contrast, when Slfn1 was knocked down, the EPCs progressed into the S phase of the cell cycle. Additionally, the overexpression of Slfn1 decreased the expression of Cyclin D1, whereas the knockdown of Slfn1 increased the expression of Cyclin D1; these findings suggest that Cyclin D1 is downstream of Slfn1 in Slfn1-mediated EPC proliferation. Taken together, these results indicate a key role for Slfn1 in the regulation of EPC biological behavior, which may provide a new target for the use of EPCs during reendothelialization.

  5. The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues

    Directory of Open Access Journals (Sweden)

    Naosuke Kamei

    2017-01-01

    Full Text Available Endothelial progenitor cells (EPCs derived from bone marrow and blood can differentiate into endothelial cells and promote neovascularization. In addition, EPCs are a promising cell source for the repair of various types of vascularized tissues and have been used in animal experiments and clinical trials for tissue repair. In this review, we focused on the kinetics of endogenous EPCs during tissue repair and the application of EPCs or stem cell populations containing EPCs for tissue regeneration in musculoskeletal and neural tissues including the bone, skeletal muscle, ligaments, spinal cord, and peripheral nerves. EPCs can be mobilized from bone marrow and recruited to injured tissue to contribute to neovascularization and tissue repair. In addition, EPCs or stem cell populations containing EPCs promote neovascularization and tissue repair through their differentiation to endothelial cells or tissue-specific cells, the upregulation of growth factors, and the induction and activation of endogenous stem cells. Human peripheral blood CD34(+ cells containing EPCs have been used in clinical trials of bone repair. Thus, EPCs are a promising cell source for the treatment of musculoskeletal and neural tissue injury.

  6. Atrial Natriuretic Peptide Accelerates Human Endothelial Progenitor Cell-Stimulated Cutaneous Wound Healing and Angiogenesis.

    Science.gov (United States)

    Lee, Tae Wook; Kwon, Yang Woo; Park, Gyu Tae; Do, Eun Kyoung; Yoon, Jung Won; Kim, Seung-Chul; Ko, Hyun-Chang; Kim, Moon-Bum; Kim, Jae Ho

    2018-05-26

    Atrial natriuretic peptide (ANP) is a powerful vasodilating peptide secreted by cardiac muscle cells, and endothelial progenitor cells (EPCs) have been reported to stimulate cutaneous wound healing by mediating angiogenesis. To determine whether ANP can promote the EPC-mediated repair of injured tissues, we examined the effects of ANP on the angiogenic properties of EPCs and on cutaneous wound healing. In vitro, ANP treatment enhanced the migration, proliferation, and endothelial tube-forming abilities of EPCs. Furthermore, small interfering RNA-mediated silencing of natriuretic peptide receptor-1, which is a receptor for ANP, abrogated ANP-induced migration, tube formation, and proliferation of EPCs. In a murine cutaneous wound model, administration of either ANP or EPCs had no significant effect on cutaneous wound healing or angiogenesis in vivo, whereas the co-administration of ANP and EPCs synergistically potentiated wound healing and angiogenesis. In addition, ANP promoted the survival and incorporation of transplanted EPCs into newly formed blood vessels in wounds. These results suggest ANP accelerates EPC-mediated cutaneous wound healing by promoting the angiogenic properties and survival of transplanted EPCs. This article is protected by copyright. All rights reserved. © 2018 by the Wound Healing Society.

  7. Multilayer Membranes of Glycosaminoglycans and Collagen I Biomaterials Modulate the Function and Microvesicle Release of Endothelial Progenitor Cells.

    Science.gov (United States)

    Dai, Bingyan; Pan, Qunwen; Li, Zhanghua; Zhao, Mingyan; Liao, Xiaorong; Wu, Keng; Ma, Xiaotang

    2016-01-01

    Multilayer composite membrane of biomaterials can increase the function of adipose stem cells or osteoprogenitor cells. Recent evidence indicates endothelial progenitor cells (EPCs) and EPCs released microvesicles (MVs) play important roles in angiogenesis and vascular repair. Here, we investigated the effects of biomaterial multilayer membranes of hyaluronic acid (HA) or chondroitin sulfate (CS) and Collagen I (Col I) on the functions and MVs release of EPCs. Layer-by-layer (LBL) technology was applied to construct the multilayer composite membranes. Four types of the membranes constructed by adsorbing either HA or CS and Col I alternatively with different top layers were studied. The results showed that all four types of multilayer composite membranes could promote EPCs proliferation and migration and inhibit cell senility, apoptosis, and the expression of activated caspase-3. Interestingly, these biomaterials increased the release and the miR-126 level of EPCs-MVs. Moreover, the CS-Col I membrane with CS on the top layer showed the most effects on promoting EPCs proliferation, EPCs-MV release, and miR-126 level in EPCs-MVs. In conclusion, HA/CS and Collagen I composed multilayer composite membranes can promote EPCs functions and release of miR-126 riched EPCs-MVs, which provides a novel strategy for tissue repair treatment.

  8. Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

    Directory of Open Access Journals (Sweden)

    Patel Amit N

    2009-12-01

    Full Text Available Abstract Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a potent means of preventing/treating some of the most fearful aspects of aging such as loss of mental, cardiovascular, and sexual function. Endothelial precursor cells (EPC provide a continual source of replenishment for damaged or senescent blood vessels. In this review we discuss the biological relevance of circulating EPC in a variety of pathologies in order to build the case that these cells act as an endogenous mechanism of regeneration. Factors controlling EPC mobilization, migration, and function, as well as therapeutic interventions based on mobilization of EPC will be reviewed. We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects.

  9. Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding

    Directory of Open Access Journals (Sweden)

    Han Wu

    2018-01-01

    Full Text Available Dysfunction of endothelial progenitor cells (EPCs contributes to cardiovascular complications in diabetes, and resveratrol has been shown to improve EPC functions. Syndecan-4 (Synd4, a cell surface heparin sulfate proteoglycan, has been shown to promote neovascularization. Thus, the present study was performed to determine whether resveratrol promoted angiogenesis of EPCs by regulating Synd4. Late EPCs were isolated from human peripheral blood and stimulated with AGEs. Western blot showed that AGEs induced Synd4 shedding in a dose- and time-dependent manner. AGE-induced Synd4 shedding was partly reversed by NAC or resveratrol, along with normalized ROS production. Overexpression of Synd4 or pretreatment of resveratrol reversed AGE-impaired tube formation of EPCs and regulated the Akt/eNOS pathway. Furthermore, resveratrol suppressed Synd4 shedding via the inhibition of oxidative stress and improved tube formation of late EPCs via the regulation of the Synd4/Akt/eNOS pathway.

  10. Theory and application on RFID

    International Nuclear Information System (INIS)

    Cho, Dae Jin

    2005-02-01

    This book tells of definition, system, operation method and classification of RFID, prospect of market, tag such as types, making process of tag, operation way and structure of tag, store of tag data and tag price, chip less tag like leader, antenna ; EPC global such as appearance of Auto-ID center, introduction of EPC system, middle ware, ONS, EPC IS and PML, a manufacturer, standardization, frequency, application cases abroad home, problems and labeling.

  11. AHP-based risk analysis of energy performance contracting projects in Russia

    International Nuclear Information System (INIS)

    Garbuzova-Schlifter, Maria; Madlener, Reinhard

    2016-01-01

    Understanding and properly managing risks that could potentially affect the target- and performance-based profits of energy performance contracting (EPC) projects are essential. It is particularly important for the establishment and success of energy service companies (ESCOs) acting in the vulnerable environment of the vast but highly energy-inefficient Russian market. This study systematically explores common risk factors and causes of risk associated with EPC projects executed in three Russian sectors: (1) industrial; (2) housing and communal services; and (3) public. Several interviews with the Russian EPC experts were accomplished and a qualitative risk assessment by using an analytic hierarchy process (AHP) approach. The data were obtained from a web-based questionnaire survey conducted among Russian EPC project executors. For each focus sector, a specific preference-based ranking of the identified risk factors and causes of risk was derived. The AHP results show that causes of risk related to the financial and regulatory aspects contribute most to the riskiness of EPC projects performed in all three focus sectors in Russia, calling for the special attention of EPC policy- and business-makers. Due to sectorial particularities and different actors involved, we conclude that there is a need for elaboration of sector-specific contractual schemes for EPC projects. - Highlights: • AHP- and survey-based study of energy performance contracting (EPC) projects in Russia. • Main risk factors and causes of risk associated with EPC projects are investigated. • In practice, lack of a feasible risk management approach in EPC projects. • Regulatory and financial risks contribute most to the EPC projects’ riskiness. • Elaboration of the sector-specific EPC project contractual scheme is required.

  12. Theory and application on RFID

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Dae Jin

    2005-02-15

    This book tells of definition, system, operation method and classification of RFID, prospect of market, tag such as types, making process of tag, operation way and structure of tag, store of tag data and tag price, chip less tag like leader, antenna ; EPC global such as appearance of Auto-ID center, introduction of EPC system, middle ware, ONS, EPC IS and PML, a manufacturer, standardization, frequency, application cases abroad home, problems and labeling.

  13. PERCOLATION TRANSITION AND TOPOLOGY

    Directory of Open Access Journals (Sweden)

    Patricia Jouannot-Chesney

    2017-06-01

    Full Text Available A number of bidimensional random structures with increasing densities are simulated to explore possible links between Euler-Poincaré characteristic (EPC, or connectivity, and percolation threshold. For each structure model, the percolation threshold is compared with a number of typical points (extrema, zero crossings... of the EPC curve. From these exercises, it can be concluded that the percolation threshold cannot be generally predicted using the evolution of the EPC.

  14. Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248.

    Science.gov (United States)

    Bagley, Rebecca G; Rouleau, Cecile; St Martin, Thia; Boutin, Paula; Weber, William; Ruzek, Melanie; Honma, Nakayuki; Nacht, Mariana; Shankara, Srinivas; Kataoka, Shiro; Ishida, Isao; Roberts, Bruce L; Teicher, Beverly A

    2008-08-01

    Angiogenesis occurs during normal physiologic processes as well as under pathologic conditions such as tumor growth. Serial analysis of gene expression profiling revealed genes [tumor endothelial markers (TEM)] that are overexpressed in tumor endothelial cells compared with normal adult endothelial cells. Because blood vessel development of malignant tumors under certain conditions may include endothelial precursor cells (EPC) recruited from bone marrow, we investigated TEM expression in EPC. The expression of TEM1 or endosialin (CD248) and other TEM has been discovered in a population of vascular endothelial growth factor receptor 2+/CD31+/CD45-/VE-cadherin+ EPC derived from human CD133+/CD34+ cells. EPC share some properties with fully differentiated endothelial cells from normal tissue, yet reverse transcription-PCR and flow cytometry reveal that EPC express higher levels of endosialin at the molecular and protein levels. The elevated expression of endosialin in EPC versus mature endothelial cells suggests that endosialin is involved in the earlier stages of tumor angiogenesis. Anti-endosialin antibodies inhibited EPC migration and tube formation in vitro. In vivo, immunohistochemistry indicated that human EPC continued to express endosialin protein in a Matrigel plug angiogenesis assay established in nude mice. Anti-endosialin antibodies delivered systemically at 25 mg/kg were also able to inhibit circulating murine EPC in nude mice bearing s.c. SKNAS tumors. EPC and bone marrow-derived cells have been shown previously to incorporate into malignant blood vessels in some instances, yet they remain controversial in the field. The data presented here on endothelial genes that are up-regulated in tumor vasculature and in EPC support the hypothesis that the angiogenesis process in cancer can involve EPC.

  15. White Paper: Unleashing Energy Efficiency Retrofits Through Energy Performance Contracts in China and the United States

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Price, Lynn [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Liu, Manzhi [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Meng, Lu [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Miao, Pei [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dai, Fan [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Evans, Meredydd [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Yu, Sha [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Roshchanka, Volha [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Halverson, Mark [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-15

    Energy performance contracting (EPC) is a mechanism that uses private sector investment and expertise to deploy energy efficiency retrofits in buildings, industries, and other types of facilities. China and the United States both have large, growing EPC markets. This White Paper shares key insights on each market, including strengths and barriers inherent to these markets, compares the two markets, and sets forth options for enhancing EPC markets in each country. The White Paper concludes with recommendations structured around common goals of both countries.

  16. Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation.

    Science.gov (United States)

    Paul, Jonathan D; Powell, Tiffany M; Thompson, Michael; Benjamin, Moshe; Rodrigo, Maria; Carlow, Andrea; Annavajjhala, Vidhya; Shiva, Sruti; Dejam, Andre; Gladwin, Mark T; McCoy, J Philip; Zalos, Gloria; Press, Beverly; Murphy, Mandy; Hill, Jonathan M; Csako, Gyorgy; Waclawiw, Myron A; Cannon, Richard O

    2007-01-01

    We investigated whether cardiac rehabilitation participation increases circulating endothelial progenitor cells (EPCs) and benefits vasculature in patients already on stable therapy previously shown to augment EPCs and improve endothelial function. Forty-six of 50 patients with coronary artery disease completed a 36-session cardiac rehabilitation program: 45 were treated with HMG-CoA reductase inhibitor (statin) therapy > or = 1 month (average baseline low-density lipoprotein cholesterol = 81 mg/dL). Mononuclear cells isolated from blood were quantified for EPCs by flow cytometry (CD133/VEGFR-2 cells) and assayed in culture for EPC colony-forming units (CFUs). In 23 patients, EPCs were stained for annexin-V as a marker of apoptosis, and nitrite was measured in blood as an indicator of intravascular nitric oxide. Endothelial progenitor cells increased from 35 +/- 5 to 63 +/- 10 cells/mL, and EPC-CFUs increased from 0.9 +/- 0.2 to 3.1 +/- 0.6 per well (both P < .01), but 11 patients had no increase in either measure. Those patients whose EPCs increased from baseline showed significant increases in nitrite and reduction in annexin-V staining (both P < .01) versus no change in patients without increase in EPCs. Over the course of the program, EPCs increased prior to increase in nitrite in the blood. Cardiac rehabilitation in patients receiving stable statin therapy and with low-density lipoprotein cholesterol at goal increases EPC number, EPC survival, and endothelial differentiation potential, associated with increased nitric oxide in the blood. Although this response was observed in most patients, a significant minority showed neither EPC mobilization nor increased nitric oxide in the blood.

  17. The influence of the Energy Performance Certificate: The Dutch case

    International Nuclear Information System (INIS)

    Murphy, Lorraine

    2014-01-01

    All European Union Member States require an Energy Performance Certificate (EPC) when buildings are constructed, sold and rented. At its introduction the EPC was considered a pioneering instrument, one that would help overcome an information deficit hindering consumer interest in energy efficient dwellings. Now that the EPC has been implemented for several years it is possible to examine its impact. This research draws on data from ex-ante and ex-post assessments of the EPC in a number of countries and presents the results of a survey of Dutch private dwelling purchasers. This survey was based on two sample populations, one received an EPC during property transaction and another did not. Differences were sought between the two samples in a number of areas relating to the adoption of energy efficiency measures. Results show that many projections about the impact of the EPC have fallen short. The EPC was found to have a weak influence, especially pre-purchase. The potential of the EPC in driving energy efficiency improvement in the existing stock is doubted especially if it continues to act independent from a mix of instruments designed to tackle multiple barriers. It is argued that the energy saving potential of existing dwellings, applauded in climate change policy, will remain unexploited if it continues to be assessed subjectively by householders. - Highlights: • Results of a survey of EPC recipients and non-recipients are presented. • The influence of the EPC is analysed descriptively and statistically. • EPC is found to have a weak influence pre and post-purchase. • More sophisticated mechanisms are needed to enhance the EPC

  18. Characterization of vascular endothelial progenitor cells from chicken bone marrow

    Directory of Open Access Journals (Sweden)

    Bai Chunyu

    2012-05-01

    Full Text Available Abstract Background Endothelial progenitor cells (EPC are a type of stem cell used in the treatment of atherosclerosis, vascular injury and regeneration. At present, most of the EPCs studied are from human and mouse, whereas the study of poultry-derived EPCs has rarely been reported. In the present study, chicken bone marrow-derived EPCs were isolated and studied at the cellular level using immunofluorescence and RT-PCR. Results We found that the majority of chicken EPCs were spindle shaped. The growth-curves of chicken EPCs at passages (P 1, -5 and -9 were typically “S”-shaped. The viability of chicken EPCs, before and after cryopreservation was 92.2% and 81.1%, respectively. Thus, cryopreservation had no obvious effects on the viability of chicken EPCs. Dil-ac-LDL and FITC-UAE-1 uptake assays and immunofluorescent detection of the cell surface markers CD34, CD133, VEGFR-2 confirmed that the cells obtained in vitro were EPCs. Observation of endothelial-specific Weibel-Palade bodies using transmission electron microscopy further confirmed that the cells were of endothelial lineage. In addition, chicken EPCs differentiated into endothelial cells and smooth muscle cells upon induction with VEGF and PDGF-BB, respectively, suggesting that the chicken EPCs retained multipotency in vitro. Conclusions These results suggest that chicken EPCs not only have strong self-renewal capacity, but also the potential to differentiate into endothelial and smooth muscle cells. This research provides theoretical basis and experimental evidence for potential therapeutic application of endothelial progenitor cells in the treatment of atherosclerosis, vascular injury and diabetic complications.

  19. A unified framework for diversity gradients : The adaptive trait continuum

    NARCIS (Netherlands)

    Carnicer, Jofre; Stefanescu, Constanti; Vila, Roger; Dinca, Vlad; Font, Xavier; Penuelas, Josep

    Aim Adaptive trait continua are axes of covariation observed in multivariate trait data for a given taxonomic group. These continua quantify and summarize life-history variation at the inter-specific level in multi-specific assemblages. Here we examine whether trait continua can provide a useful

  20. Differential relationships in the association of the Big Five personality traits with positive mental health and psychopathology

    NARCIS (Netherlands)

    Lamers, S.M.A.; Westerhof, Gerben Johan; Kovács, Viktòria; Bohlmeijer, Ernst Thomas

    2012-01-01

    According to the two continua model of mental health, psychopathology and positive mental health (emotional, psychological, and social well-being) are related but distinct continua. This study investigates the two continua model by examining whether psychopathology and positive mental health show

  1. Recovery of copper and precious metals from chalcopyrite low grade ores - choice between flotation or microorganisms leaching

    OpenAIRE

    Krstev, Boris; Golomeov, Blagoj; Konzulov, Gerasim; Gocev, Zivko

    1998-01-01

    The conventional flotation technologies cannot provide fair results when to applied to very low grade ores or to "refractory" ores. This class include intimate and nonuniform mineral associations, with partialy oxidized minerals and high secondary mineral content and also high soluble salt content, pre-activated minerals because of the excessive permeability of the deposit and of the intense circulation of waters with heavy metal ions etc. Bacterial oxidation as a means to the recovery of met...

  2. Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling

    Directory of Open Access Journals (Sweden)

    Yizhou Ye

    2016-01-01

    Full Text Available Researches show that androgens have important effects on migration of endothelial cells and endothelial protection in coronary heart disease. Endothelial progenitor cells (EPCs as a progenitor cell type that can differentiate into endothelial cells, have a critical role in angiogenesis and endothelial protection. The relationship between androgen and the functions of EPCs has animated much interest and controversy. In this study, we investigated the angiogenic and migratory functions of EPCs after treatment by dihydrotestosterone (DHT and the molecular mechanisms as well. We found that DHT treatment enhanced the incorporation of EPCs into tubular structures formed by HUVECs and the migratory activity of EPCs in the transwell assay dose dependently. Moreover, microarray analysis was performed to explore how DHT changes the gene expression profiles of EPCs. We found 346 differentially expressed genes in androgen-treated EPCs. Angiogenesis-related genes like Egr-1, Vcan, Efnb2, and Cdk2ap1 were identified to be regulated upon DHT treatment. Furthermore, the enhanced angiogenic and migratory abilities of EPCs after DHT treatment were inhibited by Egr1-siRNA transfection. In conclusion, our findings suggest that DHT markedly enhances the vessel forming ability and migration capacity of EPCs. Egr1 signaling may be a possible pathway in this process.

  3. The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells.

    Science.gov (United States)

    Liberda, Eric N; Cuevas, Azita K; Qu, Qingshan; Chen, Lung Chi

    2014-08-01

    The discovery of endothelial progenitor cells (EPCs) may help to explain observed cardiovascular effects associated with inhaled nickel nanoparticle exposures, such as increases in vascular inflammation, generation of reactive oxygen species, altered vasomotor tone and potentiated atherosclerosis in murine species. Following an acute whole body inhalation exposure to 500 µg/m(3) of nickel nanoparticles for 5 h, bone marrow EPCs from C57BL/6 mice were isolated. EPCs were harvested for their RNA or used in a variety of assays including chemotaxis, tube formation and proliferation. Gene expression was assessed for important receptors involved in EPC mobilization and homing using RT-PCR methods. EPCs, circulating endothelial progenitor cells (CEPCs), circulating endothelial cells (CECs) and endothelial microparticles (EMPs) were quantified on a BD FACSCalibur to examine endothelial damage and repair associated with the exposure. Acute exposure to inhaled nickel nanoparticles significantly increased both bone marrow EPCs as well as their levels in circulation (CEPCs). CECs were significantly elevated indicating that endothelial damage occurred due to the exposure. There was no significant difference in EMPs between the two groups. Tube formation and chemotaxis, but not proliferation, of bone marrow EPCs was impaired in the nickel nanoparticle exposed group. These results coincided with a decrease in the mRNA of receptors involved in EPC mobilization and homing. These data provide new insight into how an acute nickel nanoparticle exposure to half of the current Occupational Safety & Health Administration (OSHA) permissible exposure limit may adversely affect EPCs and exacerbate cardiovascular disease states.

  4. Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes.

    Science.gov (United States)

    Wang, Pei; Yang, Xi; Zhang, Zheng; Song, Jie; Guan, Yun-Feng; Zou, Da-Jin; Miao, Chao-Yu

    2016-06-01

    The impaired mobilization of endothelial progenitor cells (EPCs) from bone marrow (BM) critically contributes to the diabetes-associated vascular complications. Here, we investigated the relationship between the nicotinamide phosphoribosyltransferase (NAMPT)-controlled nicotinamide adenine dinucleotide (NAD) metabolism and the impaired mobilization of BM-derived EPCs in diabetic condition. The NAMPT-NAD pool in BM and BM-derived EPCs in wild-type (WT) and diabetic db/db mice was determined. Nicotinamide, a natural substrate for NAD biosynthesis, was administrated for 2weeks in db/db mice to examine the influence of enhancing NAD pool on BM and blood EPCs number. The modulations of stromal cell-derived factor-1α (SDF-1α) and endothelial nitric oxide synthase (eNOS) protein in BM were measured using immunoblotting. The EPCs intracellular NAMPT level and NAD concentration, as well as the blood EPCs number, were compared between 9 healthy people and 16 patients with type 2 diabetes mellitus (T2DM). The T2DM patients were treated with nicotinamide for two weeks and then the blood EPCs number was determined. Moreover, the association between blood EPCs numbers and EPCs intracellular NAD(+)/NAMPT protein levels in 21 healthy individuals was determined. We found that NAD concentration and NAMPT expression in BM and BM-derived EPCs of db/db mice were significantly lower than those in WT mice BM. Enhancing NAD pool not only increased the EPCs intracellular NAD concentration and blood EPCs number, but also improved post-ischemic wound healing and blood reperfusion in db/db mice with hind-limb ischemia model. Enhancing NAD pool rescued the impaired modulations of stromal cell-derived factor-1α (SDF-1α) and endothelial nitric oxide synthase (eNOS) protein levels in db/db mice BM upon hind-limb ischemia. In addition, enhancing NAD pool significantly inhibited PARP and caspase-3 activates in db/db mice BM. The intracellular NAMPT-NAD pool was positively associated with blood

  5. Effects of benazepril on functional activity of endothelial progenitor cells from hypertension patients.

    Science.gov (United States)

    Li, Yongdong; Alatan, Gaole; Ge, Zhiping; Liu, Dan

    2014-01-01

    The effect of angiotensin-converting enzyme inhibitors on hypertension patients regarding endothelial progenitor cell (EPC) functions is poorly understood. The aim of this study was to investigate the effects of benazepril on the proliferation, adhesion and migration capacity of EPCs and its possible mechanism. The functions of EPCs from hypertension patients were obviously reduced compared with control group, and this could be improved by benazepril in a dose-dependent manner, whereas this improvement were obviously blocked when AMD3100 were used together. Therefore, benazepril could obviously improve functions of EPCs from hypertension patients, and the potential mechanism may be related to SDF-1/CXCR4 axis.

  6. Effects of angiopoietin-1 on inflammatory injury in endothelial progenitor cells and blood vessels.

    Science.gov (United States)

    Wang, Yi-Qing; Song, Jing-Jin; Han, Xiao; Liu, Yi-Ye; Wang, Xi-Huang; Li, Zhi-Ming; Tzeng, Chi-Meng

    2014-01-01

    Endothelial progenitor cells (EPCs) and angiopoietin-1 (Ang-1) play important roles in vasculogenesis and angiogenesis, respectively. Thus, targeting both aspects of cardiovascular tissue regeneration may offer promising therapeutic options for cardiovascular disorders. To this end, we constructed a lentiviral vector (pNL) with the Ang-1 gene and transfected EPCs with it (Ang-1-EPCs) to investigate vasculogenesis in both cellular and animal models. Compared to controls, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) increased significantly in both untreated EPCs and in the pNL vector group. After Ang-1 transcription, ICAM-1 and VCAM-1 decreased considerably in those treatment groups. Ang-1-modified EPCs alleviated inflammatory responses induced by tumor-necrosis factor-α (TNF-α) in vitro. Moreover, Ang-1-EPC implantation inhibited neointimal hyperplasia after balloon catheter injury in rats, dramatically diminishing the intimal-media (I/M) ratio and decreasing the neointimal area. Proliferating cell nuclear antigen expression in the Ang-1-EPC group was lower than the EPC non-treatment group as well, suggesting that Ang-1-EPC improved cell survival during inflammation and promoted endothelialization in damaged blood vessels.

  7. Downregulation of microRNA-130a contributes to endothelial progenitor cell dysfunction in diabetic patients via its target Runx3.

    Directory of Open Access Journals (Sweden)

    Shu Meng

    Full Text Available Dysfunction of endothelial progenitor cells (EPCs contributes to diabetic vascular disease. MicroRNAs (miRs have emerged as key regulators of diverse cellular processes including angiogenesis. We recently reported that miR-126, miR-130a, miR-21, miR-27a, and miR-27b were downregulated in EPCs from type II diabetes mellitus (DM patients, and downregulation of miR-126 impairs EPC function. The present study further explored whether dysregulated miR-130a were also related to EPC dysfunction. EPCs were cultured from peripheral blood mononuclear cells of diabetic patients and healthy controls. Assays on EPC function (proliferation, migration, differentiation, apoptosis, and colony and tubule formation were performed. Bioinformatics analyses were used to identify the potential targets of miR-130a in EPCs. Gene expression of miR-103a and Runx3 was measured by real-time PCR, and protein expression of Runx3, extracellular signal-regulated kinase (ERK, vascular endothelial growth factor (VEGF and Akt was measured by Western blotting. Runx3 promoter activity was measured by luciferase reporter assay. A miR-130a inhibitor or mimic and lentiviral vectors expressing miR-130a, or Runx3, or a short hairpin RNA targeting Runx3 were transfected into EPCs to manipulate miR-130a and Runx3 levels. MiR-130a was decreased in EPCs from DM patients. Anti-miR-130a inhibited whereas miR-130a overexpression promoted EPC function. miR-130a negatively regulated Runx3 (mRNA, protein and promoter activity in EPCs. Knockdown of Runx3 expression enhanced EPC function. MiR-130a also upregulated protein expression of ERK/VEGF and Akt in EPCs. In conclusion, miR-130a plays an important role in maintaining normal EPC function, and decreased miR-130a in EPCs from DM contributes to impaired EPC function, likely via its target Runx3 and through ERK/VEGF and Akt pathways.

  8. Analysis of CD45- [CD34+/KDR+] endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic stroke.

    Directory of Open Access Journals (Sweden)

    Julius L Decano

    Full Text Available Identification of juvenile protective factors (JPFs which are altered with age and contribute to adult-onset diseases could identify novel pathways for reversing the effects of age, an accepted non-modifiable risk factor to adult-onset diseases. Since endothelial progenitor cells (EPCs have been observed to be altered in stroke, hypertension and hypercholesterolemia, said EPCs are candidate JPFs for adult-onset stroke. A priori, if EPC aging plays a 'master-switch JPF-role' in stroke pathogenesis, juvenile EPC therapy alone should delay stroke-onset. Using a hypertensive, transgenic-hyperlipidemic rat model of spontaneous ischemic-hemorrhagic stroke, spTg25, we tested the hypothesis that freshly isolated juvenile EPCs are JPFs that can attenuate stroke progression and delay stroke onset.FACS analysis revealed that CD45- [CD34+/KDR+] EPCs decrease with progression to stroke in spTg25 rats, exhibit differential expression of the dual endodthelin-1/VEGFsp receptor (DEspR and undergo differential DEspR-subtype specific changes in number and in vitro angiogenic tube-incorporation. In vivo EPC infusion of male, juvenile non-expanded cd45-[CD34+/KDR+] EPCs into female stroke-prone rats prior to stroke attenuated progression and delayed stroke onset (P<0.003. Detection of Y-chromosome DNA in brain microvessels of EPC-treated female spTg25 rats indicates integration of male EPCs into female rat brain microvessels. Gradient-echo MRI showed delay of ischemic-hemorrhagic lesions in EPC-treated rats. Real-time RT-PCR pathway-specific array-analysis revealed age-associated gene expression changes in CD45-[CD34+/KDR]EPC subtypes, which were accelerated in stroke-prone rats. Pro-angiogenic genes implicated in intimal hyperplasia were increased in stroke-prone rat EPCs (P<0.0001, suggesting a maladaptive endothelial repair system which acts like a double-edged sword repairing while predisposing to age-associated intimal hyperplasia.Altogether, the data

  9. Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress.

    Science.gov (United States)

    Chen, Jianfei; Song, Minbao; Yu, Shiyong; Gao, Pan; Yu, Yang; Wang, Hong; Huang, Lan

    2010-02-01

    Endothelial progenitor cells (EPCs) play an important role in preventing atherosclerosis. The factors that regulate the function of EPCs are not completely clear. Increased formation of advanced glycation endproducts (AGEs) is generally regarded as one of the main mechanisms responsible for vascular damage in patients with diabetes and atherosclerosis. AGEs lead to the generation of reactive oxygen species (ROS) and part of the regenerative capacity of EPCs seems to be due to their low baseline ROS levels and reduced sensitivity to ROS-induced cell apoptosis. Therefore, we tested the hypothesis that AGEs can alter functions and promote apoptosis in EPCs through overpress cell oxidant stress. EPCs, isolated from bone marrow, were cultured in the absence or presence of AGEs (50, 100, and 200 microg/ml). A modified Boyden's chamber was used to assess the migration of EPCs and the number of recultured EPCs was counted to measure the adhesiveness function. MTT assay was used to determine the proliferation function. ROS were analyzed using the ROS assay kit. A spectrophotometer was used to assess superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity, and PCR was used to test mRNA expression of SOD and GSH-PX. SiRNA was used to block receptor for advanced glycation endproducts (RAGEs) expression. Apoptosis was evaluated by Annexin V immunostaining and TUNEL staining. Co-culturing with AGEs increases ROS production, decreases anti-oxidant defenses, overpresses oxidant stress, inhibits the proliferation, migration, and adhesion of EPCs, and induces EPCs apoptosis. In addition, these effects were attenuated during block RAGE protein expression by siRNA. AGEs may serve to impair EPCs functions through RAGE-mediate oxidant stress, and promote EPCs sensitivity toward oxidative-stress-mediated apoptosis, which indicates a new pathophysiological mechanism of disturbed vascular adaptation in atherosclerosis and suggests that lower levels of AGEs might improve the

  10. Norepinephrine stimulates mobilization of endothelial progenitor cells after limb ischemia.

    Directory of Open Access Journals (Sweden)

    Qijun Jiang

    Full Text Available OBJECTIVE: During several pathological processes such as cancer progression, thermal injury, wound healing and hindlimb ischemia, the mobilization of endothelial progenitor cells (EPCs mobilization was enhanced with an increase of sympathetic nerve activity and norepinephrine (NE secretion, yet the cellular and molecular mechanisms involved in the effects of NE on EPCs has less been investigated. METHODS AND RESULTS: EPCs from BMs, peripheral circulation and spleens, the VEGF concentration in BM, skeletal muscle, peripheral circulation and spleen and angiogenesis in ischemic gastrocnemius were quantified in mice with hindlimbs ischemia. Systemic treatment of NE significantly increased EPCs number in BM, peripheral circulation and spleen, VEGF concentration in BM and skeletal muscle and angiogenesis in ischemic gastrocnemius in mice with hind limb ischemia, but did not affair VEGF concentration in peripheral circulation and spleen. EPCs isolated from healthy adults were cultured with NE in vitro to evaluate proliferation potential, migration capacity and phosphorylations of Akt and eNOS signal moleculars. Treatment of NE induced a significant increase in number of EPCs in the S-phase in a dose-dependent manner, as well as migrative activity of EPCs in vitro (p<0.05. The co-treatment of Phentolamine, I127, LY294002 and L-NAME with NE blocked the effects of NE on EPCs proliferation and migration. Treatment with NE significantly increased phosphorylation of Akt and eNOS of EPCs. Addition of phentolamine and I127 attenuated the activation of Akt/eNOS pathway, but metoprolol could not. Pretreatment of mice with either Phentolamine or I127 significantly attenuated the effects of NE on EPCs in vivo, VEGF concentration in BM, skeletal muscle and angiogenesis in ischemic gastrocnemius, but Metoprolol did not. CONCLUSION: These results unravel that sympathetic nervous system regulate EPCs mobilization and their pro-angiogenic capacity via α adrenoceptor

  11. Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin.

    Directory of Open Access Journals (Sweden)

    Young Yu

    Full Text Available The deployment of endovascular implants such as stents in the treatment of cardiovascular disease damages the vascular endothelium, increasing the risk of thrombosis and promoting neointimal hyperplasia. The rapid restoration of a functional endothelium is known to reduce these complications. Circulating endothelial progenitor cells (EPCs are increasingly recognized as important contributors to device re-endothelialization. Extracellular matrix proteins prominent in the vessel wall may enhance EPC-directed re-endothelialization. We examined attachment, spreading and proliferation on recombinant human tropoelastin (rhTE and investigated the mechanism and site of interaction. EPCs attached and spread on rhTE in a dose dependent manner, reaching a maximal level of 56±3% and 54±3%, respectively. EPC proliferation on rhTE was comparable to vitronectin, fibronectin and collagen. EDTA, but not heparan sulfate or lactose, reduced EPC attachment by 81±3%, while full attachment was recovered after add-back of manganese, inferring a classical integrin-mediated interaction. Integrin αVβ3 blocking antibodies decreased EPC adhesion and spreading on rhTE by 39±3% and 56±10% respectively, demonstrating a large contribution from this specific integrin. Attachment of EPCs on N-terminal rhTE constructs N25 and N18 accounted for most of this interaction, accompanied by comparable spreading. In contrast, attachment and spreading on N10 was negligible. αVβ3 blocking antibodies reduced EPC spreading on both N25 and N18 by 45±4% and 42±14%, respectively. In conclusion, rhTE supports EPC binding via an integrin mechanism involving αVβ3. N25 and N18, but not N10 constructs of rhTE contribute to EPC binding. The regulation of EPC activity by rhTE may have implications for modulation of the vascular biocompatibility of endovascular implants.

  12. Nitric oxide and superoxide dismutase modulate endothelial progenitor cell function in type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Brenner Benjamin

    2009-10-01

    Full Text Available Abstract Background The function of endothelial progenitor cells (EPCs, which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO and reactive oxygen species can regulate EPC functions. EPCs tolerate oxidative stress by upregulating superoxide dismutase (SOD, the enzyme that neutralizes superoxide anion (O2-. Therefore, we investigated the roles of NO and SOD in glucose-stressed EPCs. Methods The functions of circulating EPCs from patients with type 2 diabetes were compared to those from healthy individuals. Healthy EPCs were glucose-stressed, and then treated with insulin and/or SOD. We assessed O2- generation, NO production, SOD activity, and their ability to form colonies. Results EPCs from diabetic patients generated more O2-, had higher NAD(PH oxidase and SOD activity, but lower NO bioavailability, and expressed higher mRNA and protein levels of p22-phox, and manganese SOD and copper/zinc SOD than those from the healthy individuals. Plasma glucose and HbA1c levels in the diabetic patients were correlated negatively with the NO production from their EPCs. SOD treatment of glucose-stressed EPCs attenuated O2- generation, restored NO production, and partially restored their ability to form colonies. Insulin treatment of glucose-stressed EPCs increased NO production, but did not change O2- generation and their ability to form colonies. However, their ability to produce NO and to form colonies was fully restored after combined SOD and insulin treatment. Conclusion Our data provide evidence that SOD may play an essential role in EPCs, and emphasize the important role of antioxidant therapy in type 2 diabetic patients.

  13. Nitric oxide and superoxide dismutase modulate endothelial progenitor cell function in type 2 diabetes mellitus.

    Science.gov (United States)

    Hamed, Saher; Brenner, Benjamin; Aharon, Anat; Daoud, Deeb; Roguin, Ariel

    2009-10-30

    The function of endothelial progenitor cells (EPCs), which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO) and reactive oxygen species can regulate EPC functions. EPCs tolerate oxidative stress by upregulating superoxide dismutase (SOD), the enzyme that neutralizes superoxide anion (O2-). Therefore, we investigated the roles of NO and SOD in glucose-stressed EPCs. The functions of circulating EPCs from patients with type 2 diabetes were compared to those from healthy individuals. Healthy EPCs were glucose-stressed, and then treated with insulin and/or SOD. We assessed O2- generation, NO production, SOD activity, and their ability to form colonies. EPCs from diabetic patients generated more O2-, had higher NAD(P)H oxidase and SOD activity, but lower NO bioavailability, and expressed higher mRNA and protein levels of p22-phox, and manganese SOD and copper/zinc SOD than those from the healthy individuals. Plasma glucose and HbA1c levels in the diabetic patients were correlated negatively with the NO production from their EPCs. SOD treatment of glucose-stressed EPCs attenuated O2- generation, restored NO production, and partially restored their ability to form colonies. Insulin treatment of glucose-stressed EPCs increased NO production, but did not change O2- generation and their ability to form colonies. However, their ability to produce NO and to form colonies was fully restored after combined SOD and insulin treatment. Our data provide evidence that SOD may play an essential role in EPCs, and emphasize the important role of antioxidant therapy in type 2 diabetic patients.

  14. Study of the Effectiveness of OCR for Decentralized Data Capture and Conversion. Final Report.

    Science.gov (United States)

    Liston, David M.; And Others

    The ERIC network conversion to an OCR (Optical Character Recognition) mode of data entry was studied to analyze the potential effectiveness of OCR data entry for future EPC/s (Editorial Processing Centers). Study results are also applicable to any other system involving decentralized bibliographic data capture and conversion functions. The report…

  15. Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice.

    Science.gov (United States)

    Asai, Jun; Takenaka, Hideya; Ii, Masaaki; Asahi, Michio; Kishimoto, Saburo; Katoh, Norito; Losordo, Douglas W

    2013-10-01

    Impaired wound healing leading to skin ulceration is a serious complication of diabetes and may be caused by defective angiogenesis. Endothelial progenitor cells (EPCs) can augment neovascularisation in the ischaemic tissue. Experiments were performed to test the hypothesis that locally administered EPCs can promote wound healing in diabetes. Full-thickness skin wounds were created on the dorsum of diabetic mice. EPCs were obtained from bone marrow mononuclear cells (BMMNCs) and applied topically to the wound immediately after surgery. Vehicle and non-selective BMMNCs were used as controls. Wound size was measured on days 5, 10 and 14 after treatment, followed by resection, histological analysis and quantification of vascularity. Topical application of EPCs significantly promoted wound healing, as assessed by closure rate and wound vascularity. Immunostaining revealed that transplanted EPCs induced increased expression of vascular endothelial growth factor and basic fibroblast growth factor. Few EPCs were observed in the neovasculature based on in vivo staining of the functional vasculature. Ex vivo expanded EPCs promote wound healing in diabetic mice via mechanisms involving increased local cytokine expression and enhanced neovascularisation of the wound. This strategy exploiting the therapeutic capacity of autologously derived EPCs may be a novel approach to skin repair in diabetes. © 2012 The Authors. International Wound Journal © 2012 John Wiley & Sons Ltd and Medicalhelplines.com Inc.

  16. 78 FR 52929 - Scientific Information Request on Imaging Tests for the Diagnosis and Staging of Pancreatic...

    Science.gov (United States)

    2013-08-27

    ... submitting information from the list to upload your documents. Email submissions: src.org ">SIPS@epc- src.org... Email: src.org ">SIPS@epc- src.org . SUPPLEMENTARY INFORMATION: The Agency for Healthcare Research and... Pancreatic Adenocarcinoma, including those that describe adverse events. The entire research protocol...

  17. 78 FR 40149 - Scientific Information Request on Chronic Urinary Retention (CUR) Treatment

    Science.gov (United States)

    2013-07-03

    ... information from the list to upload your documents. Email submissions: src.org ">SIPS@epc- src.org . Print... ">SIPS@epc- src.org . SUPPLEMENTARY INFORMATION: The Agency for Healthcare Research and Quality has... in the key questions detailed below. The entire research protocol, including the key questions, is...

  18. Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway

    International Nuclear Information System (INIS)

    Zhang, Xiaoping; Mao, Haian; Chen, Jin-yuan; Wen, Shengjun; Li, Dan; Ye, Meng; Lv, Zhongwei

    2013-01-01

    Highlights: ► MicroRNA-221 is upregulated in the endothelial progenitor cells of atherosclerosis patients. ► PAK1 is a direct target of microRNA-221. ► MicroRNA-221 inhibits EPCs proliferation through c-Raf/MEK/ERK pathway. -- Abstract: Coronary artery disease (CAD) is associated with high mortality and occurs via endothelial injury. Endothelial progenitor cells (EPCs) restore the integrity of the endothelium and protect it from atherosclerosis. In this study, we compared the expression of microRNAs (miRNAs) in EPCs in atherosclerosis patients and normal controls. We found that miR-221 expression was significantly up-regulated in patients compared with controls. We predicted and identified p21/Cdc42/Rac1-activated kinase 1 (PAK1) as a novel target of miR-221 in EPCs. We also demonstrated that miR-221 targeted a putative binding site in the 3′UTR of PAK1, and absence of this site was inversely associated with miR-221 expression in EPCs. We confirmed this relationship using a luciferase reporter assay. Furthermore, overexpression of miR-221 in EPCs significantly decreased EPC proliferation, in accordance with the inhibitory effects induced by decreased PAK1. Overall, these findings demonstrate that miR-221 affects the MEK/ERK pathway by targeting PAK1 to inhibit the proliferation of EPCs

  19. Errors in the SAP reference model

    NARCIS (Netherlands)

    Mendling, J.; Aalst, van der W.M.P.; Dongen, van B.F.; Verbeek, H.M.W.

    2006-01-01

    The SAP Reference Model is a set of information models that is utilized to guide the configuration of SAP systems. A big part of these models are business process models represented in the Eventdriven Process Chains (EPC) notation. These EPC models provide a easy to comprehend overview of SAP

  20. Endothelial progenitor cell-based neovascularization : implications for therapy

    NARCIS (Netherlands)

    Krenning, Guido; van Luyn, Marja J. A.; Harmsen, Martin C.

    Ischemic cardiovascular events are a major cause of death globally. Endothelial progenitor cell (EPC)-based approaches can result in improvement of vascular perfusion and might offer clinical benefit. However, although functional improvement is observed, the lack of long-term engraftment of EPCs

  1. Catalytic Ketone Hydrodeoxygenation Mediated by Highly Electrophilic Phosphonium Cations.

    Science.gov (United States)

    Mehta, Meera; Holthausen, Michael H; Mallov, Ian; Pérez, Manuel; Qu, Zheng-Wang; Grimme, Stefan; Stephan, Douglas W

    2015-07-06

    Ketones are efficiently deoxygenated in the presence of silane using highly electrophilic phosphonium cation (EPC) salts as catalysts, thus affording the corresponding alkane and siloxane. The influence of distinct substitution patterns on the catalytic effectiveness of several EPCs was evaluated. The deoxygenation mechanism was probed by DFT methods. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease

    International Nuclear Information System (INIS)

    Werner, Christian; Boehm, Michael; Friedrich, Erik B.

    2008-01-01

    Number and function of endothelial progenitor cells (EPCs) are down-regulated in patients with coronary artery disease (CAD). Integrin-linked kinase (ILK) is a signal and adaptor protein that regulates survival of mature endothelial cells and vascular development. Here we show that EPC dysfunction in patients with CAD is paralleled by down-regulation of ILK while restoration of ILK expression rescues the migratory defect of CAD-EPCs. Human EPCs transduced with dominant-negative ILK (DN-ILK) display significantly reduced expression of CD34 + /VEGFR-2 + , DiI-Ac-LDL uptake, and Ulex europaeus lectin binding. Mechanistically, DN-ILK-transfected EPCs are characterized by decreased proliferation, while proliferation is increased in wild-type ILK-transfected EPCs. These effects are paralleled by changes in cyclin D1 expression, colony forming units, and cytoskeletal rearrangement. Functionally, ILK is necessary and sufficient for SDF-1-triggered migration and adhesion in EPCs. These data extend current knowledge about the role of ILK in EPC biology and implicate ILK as a therapeutic target in CAD.

  3. Confirmation of Non-Impacted Status (TA16-280 Complex)

    Energy Technology Data Exchange (ETDEWEB)

    Ruedig, Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-12-07

    EPC-ES finds that the materials associated with TA16-280 complex (see Figure 1) are candidates for release to the public for recycle or as sanitary/commercial waste. This finding is consistent with the requirements of DOE Order 458.1 Radiation Protection of the Public and the Environment and LANL Policy 412 Environmental Radiation Protection.

  4. Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?

    Science.gov (United States)

    King, Thomas F J; Bergin, David A; Kent, Etaoin M; Manning, Fiona; Reeves, Emer P; Dicker, Patrick; McElvaney, Noel G; Sreenan, Seamus; Malone, Fergal D; McDermott, John H

    2013-01-01

    Offspring birthweight is inversely associated with future maternal cardiovascular mortality, a relationship that has yet to be fully elucidated. Endothelial progenitor cells (EPCs) are thought to play a key role in vasculogenesis, and EPC numbers reflect cardiovascular risk. Our objective was to ascertain whether EPC number or function was reduced in mothers of low-birthweight infants. This was a prospective cohort study in a general antenatal department of a university maternity hospital. Twenty-three mothers of small for gestational age (SGA) infants (birthweight mothers of appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile) were recruited. Maternal EPC number and function, conventional cardiovascular risk markers, and cord blood adiponectin were measured. Median EPC count was lower (294 vs. 367, P = 0.005) and EPC migration was reduced (0.91 vs. 1.59, P < 0.001) in SGA compared with AGA infants, with no difference in EPC adhesion (0.221 vs. 0.284 fluorescence units, P = 0.257). Maternal triglyceride levels were higher in SGA than AGA infants (0.98 vs. 0.78 mmol/liter, P = 0.006), but there was no difference in cholesterol, glucose, insulin, glycosylated hemoglobin, adiponectin, or blood pressure. There was a moderate monotone (increasing) relationship between birthweight and umbilical cord blood adiponectin (r = 0.475, P = 0.005). Giving birth to an SGA infant was associated with lower maternal EPC number and reduced migratory function. Cord blood adiponectin was significantly correlated with birthweight.

  5. prevalence and intensity of urinary schistosomiasis among primary ...

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. Urine samples were collected from 493 pupils (5-16 years) at Wasai and Dingim wards in Minjibir ... predominantly farmers. However, due ... of infection (113.36 EPC ) than females (33.67) EPC urine. These differences in prevalence and intensity of infection between males and females were highly significant.

  6. Predictors of endothelial dysfunction and atherosclerosis in rheumatoid arthritis in Indian population

    Directory of Open Access Journals (Sweden)

    Inderjeet Verma

    2017-03-01

    Conclusions: In the present study, FMD and CIMT were impaired in RA, indicating endothelial dysfunction and accelerated atherosclerosis respectively. CRP, TNF-α, serum nitrite, DAS-28 and depleted EPC population predicted endothelial dysfunction. Age, IL-6, HDL, LDL and depleted EPC population predicted accelerated atherosclerosis.

  7. Improved model management with aggregated business process models

    NARCIS (Netherlands)

    Reijers, H.A.; Mans, R.S.; Toorn, van der R.A.

    2009-01-01

    Contemporary organizations invest much efforts in creating models of their business processes. This raises the issue of how to deal with large sets of process models that become available over time. This paper proposes an extension of Event-driven Process Chains, called the aggregate EPC (aEPC),

  8. Impact of a cardiac rehabilitation program and inflammatory state on endothelial progenitor cells in acute coronary syndrome patients.

    Science.gov (United States)

    Cesari, Francesca; Marcucci, Rossella; Gori, Anna Maria; Burgisser, Costanza; Francini, Sara; Sofi, Francesco; Gensini, Gian Franco; Abbate, Rosanna; Fattirolli, Francesco

    2013-09-01

    Among the benefits of a cardiac rehabilitation (CR) program for patients after an acute coronary syndrome (ACS) is the mobilization of endothelial progenitor cells (EPCs). However not all patients respond to CR with an increase of EPC. We performed this study to identify the characteristics of patients who will not benefit from an increase of EPCs at the end of a CR program. 112 ACS patients were admitted to a four-week CR program. EPCs, high sensitivity C-reactive protein (hsCRP) and NT-ProBNP levels were determined at the beginning (T1) and at the end (T2) of the CR program. All patients performed a cardiopulmonary exercise test at T1 and at T2. EPCs were defined as CD34+KDR+, CD133+KDR+ and CD34+CD133+KDR+. hsCRP and NT-ProBNP were measured by nephelometric and immunometric method, respectively. At T2, we observed a significant increase of EPCs (p=0.001), VO2 peak, Watt max HDL-cholesterol (pprogram. A CR program determines an increase of EPCs with a decrease of CRP and NT-ProBNP. A different trend for EPCs can be detected among patients correlated to CRP levels and exercise tolerance. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  9. Passerine extrapair mating dynamics: a bayesian modeling approach comparing four species

    NARCIS (Netherlands)

    Brommer, J.E.; Alho, J.S.; Biard, C.; Chapman, J.R.; Charmantier, A.; Dreiss, A.; Hartley, I.R.; Hjernquist, M.B.; Kempenaers, B.; Komdeur, J.; Laaksonen, T.; Lehtonen, P.K.; Lubjuhn, T.; Patrick, S.C.; Rosivall, B.; Tinbergen, J.M.; Van der Velde, M.; Van Oers, K.; Wilk, T.; Winkel, W.

    2010-01-01

    In many socially monogamous animals, females engage in extrapair copulation (EPC), causing some broods to contain both within‐pair and extrapair young (EPY). The proportion of all young that are EPY varies across populations and species. Because an EPC that does not result in EPY leaves no forensic

  10. Passerine Extrapair Mating Dynamics : A Bayesian Modeling Approach Comparing Four Species

    NARCIS (Netherlands)

    Brommer, Jon E.; Alho, Jussi S.; Biard, Clotilde; Chapman, Joanne R.; Charmantier, Anne; Dreiss, Amelie; Hartley, Ian R.; Hjernquist, Marten B.; Kempenaers, Bart; Komdeur, Jan; Laaksonen, Toni; Lehtonen, Paula K.; Lubjuhn, Thomas; Patrick, Samantha C.; Rosivall, Balazs; Tinbergen, Joost M.; van der Velde, Marco; van Oers, Kees; Wilk, Tomasz; Winkel, Wolfgang; Hjernquist, Mårten B.; Boughman, Janette; DeAngelis, Donald L.

    In many socially monogamous animals, females engage in extrapair copulation (EPC), causing some broods to contain both within-pair and extrapair young (EPY). The proportion of all young that are EPY varies across populations and species. Because an EPC that does not result in EPY leaves no forensic

  11. Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells.

    Science.gov (United States)

    You, Jinzhi; Sun, Jiacheng; Ma, Teng; Yang, Ziying; Wang, Xu; Zhang, Zhiwei; Li, Jingjing; Wang, Longgang; Ii, Masaaki; Yang, Junjie; Shen, Zhenya

    2017-08-03

    Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous studies proved the promotional effect of curcumin on neovascularization in wound healing of diabetes. Thus, we hypothesize that curcumin could promote neovascularization at sites of hindlimb ischemia in diabetes and might take effect via modulating the function of EPCs. Streptozotocin-induced type 1 diabetic mice and nondiabetic mice both received unilateral hindlimb ischemic surgery. Curcumin was then administrated to the mice by lavage for 14 days consecutively. Laser Doppler perfusion imaging was conducted to demonstrate the blood flow reperfusion. Capillary density was measured in the ischemic gastrocnemius muscle. In addition, angiogenesis, migration, proliferation abilities, and senescence were determined in EPCs isolated from diabetic and nondiabetic mice. Quantitative PCR was then used to determine the mRNA expression of vascular endothelial growth factor (VEGF) and angiopoetin-1 (Ang-1) in EPCs. Curcumin application to type 1 diabetic mice significantly improved blood reperfusion and increased the capillary density in ischemic hindlimbs. The in-vitro study also revealed that the angiogenesis, migration, and proliferation abilities of EPCs and the number of senescent EPCs were reversed by curcumin application. Quantitative PCR confirmed the overexpression of VEGF-A and Ang-1 in EPCs after curcumin treatment. Curcumin could enhance neovascularization via promoting the function of EPCs in a diabetic mouse hindlimb ischemia model.

  12. Vascular smooth muscle cells for use in vascular tissue engineering obtained by endothelial-to-mesenchymal transdifferentiation (EnMT) on collagen matrices

    NARCIS (Netherlands)

    Krenning, Guido; Moonen, Jan-Renier A. J.; van Luyn, Marja J. A.; Harmsen, Martin C.

    The discovery of the endothelial progenitor cell (EPC) has led to an intensive research effort into progenitor cell-based tissue engineering of (small-diameter) blood vessels. Herein, EPC are differentiated to vascular endothelial cells and serve as the inner lining of bioartificial vessels. As yet,

  13. Performance-based potential for residential energy efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Performance-based potential for residential energy efficiency

    2013-01-15

    Energy performance contracts (EPCs) have proven an effective mechanism for increasing energy efficiency in nearly all sectors of the economy since their introduction nearly 30 years ago. In the modern form, activities undertaken as part of an EPC are scoped and implemented by experts with specialized technical knowledge, financed by commercial lenders, and enable a facility owner to limit risk and investment of time and resources while receiving the rewards of improved energy performance. This report provides a review of the experiences of the US with EPCs and discusses the possibilities for the residential sector to utilize EPCs. Notably absent from the EPC market is the residential segment. Historically, research has shown that the residential sector varies in several key ways from markets segments where EPCs have proven successful, including: high degree of heterogeneity of energy use characteristics among and within households, comparatively small quantity of energy consumed per residence, limited access to information about energy consumption and savings potential, and market inefficiencies that constrain the value of efficiency measures. However, the combination of recent technological advances in automated metering infrastructure, flexible financing options, and the expansion of competitive wholesale electricity markets to include energy efficiency as a biddable supply-side resource present an opportunity for EPC-like efforts to successfully engage the residential sector, albeit following a different model than has been used in EPCs traditionally.(Author)

  14. Endothelial progenitor cells in long-standing asymptomatic type 1 diabetic patients with or without diabetic nephropathy

    DEFF Research Database (Denmark)

    Reinhard, Henrik; Jacobsen, Peter Karl; Lajer, Maria

    2011-01-01

    with or without DN and to study the effect of CVD and medication on EPC numbers. Methods: We examined EPC numbers in 37 type 1 diabetic patients with DN and 35 type 1 diabetic patients with long-standing normoalbuminuria. Patients were without symptoms of CVD and the prevalence of CVD was previously shown......A decrease in the number and dysfunction of endothelial progenitor cells (EPC) may increase the risk for progression of cardiovascular disease (CVD) in type 1 diabetic patients with diabetic nephropathy (DN). Our aim was to evaluate EPC numbers in asymptomatic CVD type 1 diabetic patients...... with CVD (p > 0.05). Conventional risk factors were significantly higher in patients with DN and they received more CVD-preventive treatment. All patients receiving simvastatin or calcium-channel blockers had higher numbers of EPC compared to patients not treated with these drugs. Conclusions: Asymptomatic...

  15. Endothelial progenitor cells dysfunction and impaired tissue reparation: The missed link in diabetes mellitus development.

    Science.gov (United States)

    Berezin, Alexander E

    Diabetes mellitus (DM) is considered a leading cause of premature cardiovascular (CV) mortality and morbidity in general population and in individuals with known CV disease. Recent animal and clinical studies have shown that reduced number and weak function of endothelial progenitor cells (EPCs) may not only indicate to higher CV risk, but contribute to the impaired heart and vessels reparation in patients with DM. Moreover, EPCs having a protective impact on the vasculature may mediate the functioning of other organs and systems. Therefore, EPCs dysfunction is probably promising target for DM treatment strategy, while the role of restoring of EPCs number and functionality in CV risk diminish and reduce of DM-related complications is not fully clear. The aim of the review is summary of knowledge regarding EPCs dysfunction in DM patients. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  16. The association between circulating endothelial progenitor cells and coronary collateral formation.

    Science.gov (United States)

    Tokgözoğlu, Lale; Yorgun, Hikmet; Gürses, Kadri Murat; Canpolat, Uğur; Ateş, Ahmet Hakan; Tülümen, Erol; Kaya, Ergün Barış; Aytemir, Kudret; Kabakçı, Giray; Tuncer, Murat; Oto, Ali

    2011-12-01

    We investigated the relationship between coronary collateral formation and circulating endothelial progenitor cells (EPC) in patients undergoing coronary angiography. Circulating CD133(+)/34(+) and CD34(+)/KDR(+) EPCs were determined in 68 patients (normal coronary vessels in 24 patients and coronary artery disease (CAD) in 44 patients) (age: 58.7 ± 10.1, 64.7% male). Circulating EPCs were higher among patients with normal coronary vessels compared to patients with CAD for CD133(+)/34(+) (p collateral formation (p collateral formation after adjustment for other cardiovascular risk factors and extent of CAD (p = 0.037). In patients with severe coronary stenosis, those with increased circulating EPCs had better collateral formation compared to those with lower EPC counts. Our findings implicate that in addition to presence of critical stenosis, intact response of bone marrow is necessary for collateral formation in CAD. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  17. Pioglitazone Improves In Vitro Viability and Function of Endothelial Progenitor Cells from Individuals with Impaired Glucose Tolerance

    Science.gov (United States)

    Spigoni, Valentina; Picconi, Angela; Cito, Monia; Ridolfi, Valentina; Bonomini, Sabrina; Casali, Chiara; Zavaroni, Ivana; Gnudi, Luigi; Metra, Marco; Dei Cas, Alessandra

    2012-01-01

    Background Evidence suggests that the PPARγ-agonist insulin sensitizer pioglitazone, may provide potential beneficial cardiovascular (CV) effects beyond its anti-hyperglycaemic function. A reduced endothelial progenitor cell (EPC) number is associated with impaired glucose tolerance (IGT) or diabetes, conditions characterised by increased CV risk. Aim To evaluate whether pioglitazone can provide benefit in vitro in EPCs obtained from IGT subjects. Materials and Methods Early and late-outgrowth EPCs were obtained from peripheral blood mononuclear cells of 14 IGT subjects. The in vitro effect of pioglitazone (10 µM) with/without PPARγ-antagonist GW9662 (1 µM) was assessed on EPC viability, apoptosis, ability to form tubular-like structures and pro-inflammatory molecule expression. Results Pioglitazone increased early and late-outgrowth EPC viability, with negligible effects on apoptosis. The capacity of EPCs to form tubular-like structures was improved by pioglitazone in early (mean increase 28%; p = 0.005) and late-outgrowth (mean increase 30%; p = 0.037) EPCs. Pioglitazone reduced ICAM-1 and VCAM-1 adhesion molecule expression in both early (p = 0.001 and p = 0.012 respectively) and late-outgrowth (p = 0.047 and p = 0.048, respectively) EPCs. Similarly, pioglitazone reduced TNFα gene and protein expression in both early (p = 0.034;p = 0.022) and late-outgrowth (p = 0.026;p = 0.017) EPCs compared to control. These effects were prevented by incubation with the PPARγ-antagonist GW9662. Conclusion Pioglitazone exerts beneficial effects in vitro on EPCs isolated from IGT subjects, supporting the potential implication of pioglitazone as a CV protective agents. PMID:23139771

  18. Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression.

    Directory of Open Access Journals (Sweden)

    Ingo Ahrens

    Full Text Available Endothelial progenitor cells (EPCs can be purified from peripheral blood, bone marrow or cord blood and are typically defined by a limited number of cell surface markers and a few functional tests. A detailed in vitro characterization is often restricted by the low cell numbers of circulating EPCs. Therefore in vitro culturing and expansion methods are applied, which allow at least distinguishing two different types of EPCs, early and late EPCs. Herein, we describe an in vitro culture technique with the aim to generate high numbers of phenotypically, functionally and genetically defined early EPCs from human cord blood. Characterization of EPCs was done by flow cytometry, immunofluorescence microscopy, colony forming unit (CFU assay and endothelial tube formation assay. There was an average 48-fold increase in EPC numbers. EPCs expressed VEGFR-2, CD144, CD18, and CD61, and were positive for acetylated LDL uptake and ulex lectin binding. The cells stimulated endothelial tube formation only in co-cultures with mature endothelial cells and formed CFUs. Microarray analysis revealed highly up-regulated genes, including LL-37 (CAMP, PDK4, and alpha-2-macroglobulin. In addition, genes known to be associated with cardioprotective (GDF15 or pro-angiogenic (galectin-3 properties were also significantly up-regulated after a 72 h differentiation period on fibronectin. We present a novel method that allows to generate high numbers of phenotypically, functionally and genetically characterized early EPCs. Furthermore, we identified several genes newly linked to EPC differentiation, among them LL-37 (CAMP was the most up-regulated gene.

  19. Adsorption of egg phosphatidylcholine to an air/water and triolein/water bubble interface: use of the 2-dimensional phase rule to estimate the surface composition of a phospholipid/triolein/water surface as a function of surface pressure.

    Science.gov (United States)

    Mitsche, Matthew A; Wang, Libo; Small, Donald M

    2010-03-11

    Phospholipid monolayers play a critical role in the structure and stabilization of biological interfaces, including all membranes, the alveoli of the lungs, fat droplets in adipose tissue, and lipoproteins. The behavior of phospholipids in bilayers and at an air-water interface is well understood. However, the study of phospholipids at oil-water interfaces is limited due to technical challenges. In this study, egg phosphatidylcholine (EPC) was deposited from small unilamellar vesicles onto a bubble of either air or triolein (TO) formed in a low-salt buffer. The surface tension (gamma) was measured using a drop tensiometer. We observed that EPC binds irreversibly to both interfaces and at equilibrium exerts approximately 12 and 15 mN/m of pressure (Pi) at an air and TO interface, respectively. After EPC was bound to the interface, the unbound EPC was washed out of the cuvette, and the surface was compressed to study the Pi/area relationship. To determine the surface concentration (Gamma), which cannot be measured directly, compression isotherms from a Langmuir trough and drop tensiometer were compared. The air-water interfaces had identical characteristics using both techniques; thus, Gamma on the bubble can be determined by overlaying the two isotherms. Both TO and EPC are surface-active, so in a mixed TO/EPC monolayer, both molecules will be exposed to water. Since TO is less surface-active than EPC, as Pi increases, the TO is progressively ejected. To understand the Pi/area isotherm of EPC on a TO bubble, a variety of TO-EPC mixtures were spread at the air-water interface. The isotherms show an abrupt break in the curve caused by the ejection of TO from the monolayer into a new bulk phase. By overlaying the compression isotherm above the ejection point with a TO bubble compression isotherm, Gamma can be estimated. This allows determination of Gamma of EPC on a TO bubble as a function of Pi.

  20. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function.

    Directory of Open Access Journals (Sweden)

    Yi-Wen Lin

    Full Text Available The number and function of endothelial progenitor cells (EPCs are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in GroEL1-administered hind limb-ischemic C57BL/B6 and C57BL/10ScNJ (a toll-like receptor 4 (TLR4 mutation mice and human EPCs. In mice, laser Doppler imaging, flow cytometry, and immunohistochemistry were used to evaluate the degree of neo-vasculogenesis, circulating level of EPCs, and expression of CD34, vWF, and endothelial nitric oxide synthase (eNOS in vessels. Blood flow in the ischemic limb was significantly impaired in C57BL/B6 but not C57BL/10ScNJ mice treated with GroEL1. Circulating EPCs were also decreased after GroEL1 administration in C57BL/B6 mice. Additionally, GroEL1 inhibited the expression of CD34 and eNOS in C57BL/B6 ischemic muscle. In vitro, GroEL1 impaired the capacity of differentiation, mobilization, tube formation, and migration of EPCs. GroEL1 increased senescence, which was mediated by caspases, p38 MAPK, and ERK1/2 signaling in EPCs. Furthermore, GroEL1 decreased integrin and E-selectin expression and induced inflammatory responses in EPCs. In conclusion, these findings suggest that TLR4 and impaired NO-related mechanisms could contribute to the reduced number and functional activity of EPCs in the presence of GroEL1 from C. pneumoniae.

  1. MicroRNA 107 partly inhibits endothelial progenitor cells differentiation via HIF-1β.

    Directory of Open Access Journals (Sweden)

    Shu Meng

    Full Text Available Endothelial progenitor cells (EPCs play an important role in tissue repair after ischemic heart disease. In particular, the recovery of endothelial function is reliant on the ability and rate of EPCs differentiate into mature endothelial cells. The present study evaluated the effect of microRNA 107 (miR-107 on the mechanism of EPCs differentiation. EPCs were isolated from rats' bone marrow and miR-107 expression of EPCs in hypoxic and normoxic conditions were measured by real-time qualitative PCR. CD31 was analyzed by flow cytometry and eNOS was examined by real-time qualitative PCR and western blotting and these were used as markers of EPC differentiation. In order to reveal the mechanism, we used miR107 inhibitor and lentiviral vector expressing a short hairpin RNA (shRNA that targets miR-107 and hypoxia-inducible factor-1 β (HIF-1β to alter miR107 and HIF-1β expression. MiR-107 expression were increased in EPCs under hypoxic conditions. Up-regulation of miR-107 partly suppressed the EPCs differentiation induced in hypoxia, while down-regulation of miR-107 promoted EPC differentiation. HIF-1β was the target. This study indicated that miR-107 was up-regulated in hypoxia to prevent EPCs differentiation via its target HIF-1β. The physiological mechanisms of miR-107 must be evaluated if it is to be used as a potential anti-ischemia therapeutic regime.

  2. Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy.

    Science.gov (United States)

    Bagley, Rebecca G; Weber, William; Rouleau, Cecile; Teicher, Beverly A

    2005-11-01

    Tumor vasculature is irregular, abnormal, and essential for tumor growth. Pericytes and endothelial precursor cells (EPC) contribute to the formation of blood vessels under angiogenic conditions. As primary cells in culture, pericytes and EPC share many properties such as tube/network formation and response to kinase inhibitors selective for angiogenic pathways. Expression of cell surface proteins including platelet-derived growth factor receptor, vascular cell adhesion molecule, intercellular adhesion molecule, CD105, desmin, and neural growth proteoglycan 2 was similar between pericytes and EPC, whereas expression of P1H12 and lymphocyte function-associated antigen-1 clearly differentiates the cell types. Further distinction was observed in the molecular profiles for expression of angiogenic genes. Pericytes or EPC enhanced the invasion of MDA-MB-231 breast cancer cells in a coculture assay system. The s.c. coinjection of live pericytes or EPC along with MDA-MB-231 cells resulted in an increased rate of tumor growth compared with coinjection of irradiated pericytes or EPC. Microvessel density analysis indicated there was no difference in MDA-MB-231 tumors with or without EPC or pericytes. However, immunohistochemical staining of vasculature suggested that EPC and pericytes may stabilize or normalize vasculature rather than initiate vasculogenesis. In addition, tumors arising from the coinjection of EPC and cancer cells were more likely to develop lymphatic vessels. These results support the notion that pericytes and EPC contribute to malignancy and that these cell types can be useful as cell-based models for tumor vascular development and selection of agents that may provide therapeutic benefit.

  3. Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing.

    Science.gov (United States)

    Wang, Chenggui; Wang, Qingqing; Gao, Wendong; Zhang, Zengjie; Lou, Yiting; Jin, Haiming; Chen, Xiaofeng; Lei, Bo; Xu, Huazi; Mao, Cong

    2018-03-15

    Wound therapy with a rapid healing performance remains a critical clinical challenge. Cellular delivery is considered to be a promising approach to improve the efficiency of healing, yet problems such as compromised cell viability and functionality arise due to the inefficient delivery. Here, we report the efficient delivery of endothelial progenitor cells (EPCs) with a bioactive nanofibrous scaffold (composed of collagen and polycaprolactone and bioactive glass nanoparticles, CPB) for enhancing wound healing. Under the stimulation of CPB nanofibrous system, the viability and angiogenic ability of EPCs were significantly enhanced through the activation of Hif-1α/VEGF/SDF-1α signaling. In vivo, CPB/EPC constructs significantly enhanced the formation of high-density blood vessels by greatly upregulating the expressions of Hif-1α, VEGF, and SDF-1α. Moreover, owing to the increased local delivery of cells and fast neovascularization within the wound site, cell proliferative activity, granulation tissue formation, and collagen synthesis and deposition were greatly promoted by CPB/EPC constructs resulting in rapid re-epithelialization and regeneration of skin appendages. As a result, the synergistic enhancement of wound healing was observed from CPB/EPC constructs, which suggests the highly efficient delivery of EPCs. CPB/EPC constructs may become highly competitive cell-based therapeutic products for efficient impaired wound healing application. This study may also provide a novel strategy to develop bioactive cell therapy constructs for angiogenesis-related regenerative medicine. This paper reported a highly efficient local delivery of EPCs using bioactive glass-based CPB nanofibrous scaffold for enhancing angiogenesis and wound regeneration. In vitro study showed that CPB can promote the proliferation, migration, and tube formation of EPCs through upregulation of the Hif-1α/VEGF/SDF-1α signaling pathway, indicating that the bioactivity and angiogenic ability of

  4. Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study.

    Science.gov (United States)

    Kaur, Savneet; Kumar, T R Santhosh; Uruno, Akira; Sugawara, Akira; Jayakumar, Karunakaran; Kartha, Chandrasekharan Cheranellore

    2009-11-01

    Recent studies have reported a marked impairment in the number and functions of endothelial progenitor cells (EPCs) in patients with coronary artery disease (CAD). In view of an important role of eNOS in angiogenesis, in the present study, we evaluated the effects of eNOS gene transfer in ex vivo expanded EPCs isolated from patients with CAD. The expanded EPCs were transfected with mammalian expression vector pcDNA3.1-eNOS containing the full-length human eNOS gene using lipofectamine. About 35-40% of the eNOS-EPCs had higher expression of eNOS as compared to untransfected EPCs. EPCs transfected with pcDNA3.0-EGFP, the plasmid vector expressing green fluorescent protein (GFP) were used as control. The untransfected, GFP-transfected and eNOS-transfected EPCs were compared in terms of important functional attributes of angiogenesis such as proliferation, migration, differentiation and adhesion/integration into tube-like structures in vitro. Functional studies revealed that in the presence of defined growth conditions, compared to the untransfected and GFP-transfected cells, eNOS-EPCs from patients with CAD have a significant increase in [3H] thymidine-labeled DNA (P < 0.01), migration (14.6 +/- 1.8 and 16.5 +/- 1.9 vs. 23.5 +/- 3.4 cells/field, P < 0.01), ability to differentiate into endothelial-like spindle-shaped cells (46 +/- 4.5 and 56.5 +/- 2.1 vs. 93.2 +/- 6.6 cells/field, P < 0.001) and also incorporation into tube-like structures on the matrigel (GFP-EPCs: 21.25 +/- 2.9 vs. GFP-eNOS-EPCs: 34.5 +/- 5.5 cells/field, P < 0.05). We conclude that eNOS gene transfection is a valuable approach to augment angiogenic properties of ex vivo expanded EPCs and eNOS-modified EPCs may offer significant advantages than EPCs alone in terms of their clinical use in patients with myocardial ischemia.

  5. Comparison of three fluorescence labeling and tracking methods of endothelial progenitor cells in laser-injured retina

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    Hui Shi

    2018-04-01

    Full Text Available AIM: To compare three kinds of fluorescent probes for in vitro labeling and in vivo tracking of endothelial progenitor cells (EPCs in a mouse model of laser-induced retinal injury. METHODS: EPCs were isolated from human umbilical cord blood mononuclear cells and labeled with three different fluorescent probes: 5-(and-6-carboxyfluorescein diacetate succinimidyl ester (CFSE, 1,1′-dilinoleyl-3,3,3′,3′-tetramethylindo-carbocyanine perchlorate linked acetylated low-density lipoprotein (DiI-AcLDL, and green fluorescent protein (GFP. The fluorescent intensity of EPCs was examined by confocal microscopy. Survival rate of labeled EPCs was calculated with trypan blue staining, and their adhesive capability was assessed. A mouse model of retinal injury was induced by laser, and EPCs were injected into the vitreous cavity. Frozen section and fluorescein angiography on flat-mounted retinal samples was employed to track the labeled EPCs in vivo. RESULTS: EPCs labeled with CFSE and DiI-AcLDL exhibited an intense green and red fluorescence at the beginning; the fluorescence intensity decreased gradually to 20.23% and 49.99% respectively, after 28d. On the contrary, the florescent intensity of GFP-labeled EPCs increased in a time-dependent manner. All labeled EPCs showed normal morphology and no significant change in survival and adhesive capability. In the mouse model, transplantation of EPCs showed a protective effect against retinal injury. EPCs labeled with CFSE and DiI-AcLDL were successfully tracked in mice during the development of retinal injury and repair; however, GFP-labeled EPCs were not detected in the laser-injured mouse retina. CONCLUSION: The three fluorescent markers used in this study have their own set of advantages and disadvantages. CFSE and DiI-AcLDL are suitable for short-term EPC-labeling, while GFP should be used for long-term labeling. The choice of fluorescent markers should be guided by the purpose of the study.

  6. Endothelial progenitor cells display clonal restriction in multiple myeloma

    International Nuclear Information System (INIS)

    Braunstein, Marc; Özçelik, Tayfun; Bağişlar, Sevgi; Vakil, Varsha; Smith, Eric LP; Dai, Kezhi; Akyerli, Cemaliye B; Batuman, Olcay A

    2006-01-01

    In multiple myeloma (MM), increased neoangiogenesis contributes to tumor growth and disease progression. Increased levels of endothelial progenitor cells (EPCs) contribute to neoangiogenesis in MM, and, importantly, covary with disease activity and response to treatment. In order to understand the mechanisms responsible for increased EPC levels and neoangiogenic function in MM, we investigated whether these cells were clonal by determining X-chromosome inactivation (XCI) patterns in female patients by a human androgen receptor assay (HUMARA). In addition, EPCs and bone marrow cells were studied for the presence of clonotypic immunoglobulin heavy-chain (IGH) gene rearrangement, which indicates clonality in B cells; thus, its presence in EPCs would indicate a close genetic link between tumor cells in MM and endothelial cells that provide tumor neovascularization. A total of twenty-three consecutive patients who had not received chemotherapy were studied. Screening in 18 patients found that 11 displayed allelic AR in peripheral blood mononuclear cells, and these patients were further studied for XCI patterns in EPCs and hair root cells by HUMARA. In 2 patients whose EPCs were clonal by HUMARA, and in an additional 5 new patients, EPCs were studied for IGH gene rearrangement using PCR with family-specific primers for IGH variable genes (V H ). In 11 patients, analysis of EPCs by HUMARA revealed significant skewing (≥ 77% expression of a single allele) in 64% (n = 7). In 4 of these patients, XCI skewing was extreme (≥ 90% expression of a single allele). In contrast, XCI in hair root cells was random. Furthermore, PCR amplification with V H primers resulted in amplification of the same product in EPCs and bone marrow cells in 71% (n = 5) of 7 patients, while no IGH rearrangement was found in EPCs from healthy controls. In addition, in patients with XCI skewing in EPCs, advanced age was associated with poorer clinical status, unlike patients whose EPCs had random XCI

  7. Evaluation of training in the health sector. Results of training on the use of medicines Evaluación de la formación continua en el sector sanitario. Resultados de la formación en uso racional del medicamento

    Directory of Open Access Journals (Sweden)

    Pilar Pineda-Herrero

    2012-11-01

    Full Text Available The evaluation of training efficacy is one of the challenges of today’s organizations. In this article we present the results of an evaluation carried out in order to measure transfer of a training plan about the rational use of medicines addressed to 1550 health professionals. Data is collected by means of a survey to the trainee, two months after the training program. Results show that most of the trainees have improved their professional performance, in special the duties related to the selection and use of medicines. Key factors for transfer are also detected, such as motivation and support from the organization. In the paper, we reflect on the strengths and weaknesses of the training plan so as to help other researchers and practitioners to advance towards improving transfer of training and the efficacy of training.  La evaluación de la eficacia de la formación es un reto para las organizaciones de hoy en día.  En este artículo presentamos los resultados de una evaluación llevada a cabo para medir la transferencia de un plan de formación sobre el uso racional de medicamentos dirigido a 1550 profesionales del sector sanitario.  Los datos se recogen mediante una encuesta al participante, dos meses después de la formación.  Los resultados muestran que muchos de los participantes mejoraron su actuación profesional, en especial en sus funciones relacionadas con la selección y uso de medicamentos.  También se detectan factores clave para la transferencia, tales como la motivación y el apoyo de la organización. En el artículo, reflexionamos sobre los puntos fuertes y débiles del plan de formación para así ayudar a otros investigadores/as y prácticos/as a avanzar en la mejora de la transferencia y la eficacia de la formación.

  8. Factores asociados al estado de salud de adolescentes con exposición continua a plomo, arsénico y flúor, que viven cerca de una zona metalúrgica en la ciudad de San Luis Potosí

    OpenAIRE

    Cossío Torres, Patricia Elizabeth

    2011-01-01

    identificar los factores individuales, familiares, sociales y de exposición a agentes contaminantes; que intervienen en el estado de salud actual (nutricional, cognitivo, salud mental y rendimiento escolar) y conductas de riesgo para la salud (agresión/delincuencia, consumo riesgoso y dañino de alcohol, consumo de tabaco y uso/abuso de sustancias) de un grupo de adolescentes expuestos crónicamente a plomo, arsénico y flúor. Tesis de Posgrado de la Universidad Autonoma de San Luis Pot...

  9. Impacto da formação profissional contínua nos custos do tratamento das feridas crónicas Impacto de la formación profesional continua en los costes de tratamiento de las heridas crónicas Impact of continuing professional education on treatment costs for chronic wounds

    Directory of Open Access Journals (Sweden)

    Pedro João Soares Gaspar

    2010-07-01

    Full Text Available Nos contextos da prestação de cuidados de saúde, os avanços da ciência e da tecnologia rapidamente desactualizam as competências específicas adquiridas nas escolas. Os erros clínicos, más práticas e performances deficientes, frequentemente associadas ao défice de formação, para além dos prejuízos clínicos, imputam enorme carga económica aos custos da saúde. No investimento em formação, mais do que saber quanto se gasta, importa saber quanto se pode poupar tornando mais competentes os profissionais de saúde. Com o objectivo geral de desenvolver um modelo de estimação dos custos da não formação, construímos e validamos (1 casos clínicos virtuais de pessoas com feridas crónicas, (2 modelo matemático para estimação dos Custos Óptimos (baseados nas decisões clínicas óptimas e (3 simulador de tomada de decisão para construir as matrizes de Custos da Acção (baseados nas decisões terapêuticas registadas no simulador. Desenvolvemos um estudo analítico transversal numa amostra não aleatória de 78 enfermeiros com diferentes níveis de formação e experiência no tratamento de feridas crónicas. Nos resultados reunimos evidência empírica de que os custos do tratamento são mais elevados entre os profissionais que não frequentaram formação acreditada específica, e de que os custos tendem a baixar à medida que o número de horas de formação sobe.En los contextos de la prestación de cuidados de salud, los avances de la ciencia y de la tecnología desactualizan rápidamente las competencias específicas adquiridas en las escuelas. Los errores clínicos, las malas prácticas y los desempeños deficientes, a menudo asociados al déficit de formación, además de los perjuicios clínicos, imputan una enorme carga económica a los costes en salud. En la inversión en formación, más que saber cuánto se gasta, importa saber cuánto puede ahorrarse haciendo más competentes a los profesionales de salud. Con el objetivo general de desarrollar un modelo de estimación de los costes de la no formación, construimos y validamos (1 casos clínicos virtuales de personas con heridas crónicas, (2 un modelo matemático para estimación de los costes óptimos (basados en las decisiones clínicas óptimas y (3 un simulador de toma de decisión para construir las matrices de costes de la acción (basados en las decisiones terapéuticas registradas en el simulador. Desarrollamos un estudio analítico y transversal en una muestra no aleatoria de 78 enfermeros con distintos niveles de formación y experiencia en el tratamiento de heridas crónicas. En los resultados reunimos evidencia empírica de que los costes de tratamiento son más elevados entre los profesionales que no asistieron a la formación acreditada específica, y de que los costes tienden a disminuir a medida que el número de horas de formación aumenta.In health care provision, scientific and technological advances rapidly make specific skills acquired at school totally obsolete. Clinical errors, bad practices and inadequate performances frequently attributed to insufficient training bring a tremendous economic load to health costs. In investing in training, rather than knowing how much will be spent, we need to know how much we can save by making healthcare providers more skilled. Our general aim was to develop a model to estimate the costs of non-training. We built and validated (1 virtual clinical cases of patients with chronic wounds, (2 a mathematical model to estimate Optimal Costs (based on optimal clinical decisions, and (3 a decision-making simulator to prepare Cost of Action matrices (based on the treatment decisions recorded in the simulator. We developed a cross-sectional study, using a non-random cohort of 78 nurses with different levels of specific training and experience in the diagnosis and treatment of chronic wounds. The outcomes provided us with the empirical knowledge that the costs involved in the treatment are higher among healthcare providers who have not attended specific accredited training, and that the costs are likely to fall as the number of training hours increases.

  10. Effects of continuous drought and immersion on hatchability of Ochlerotatus albifasciatus (Diptera: Culicidae eggs stored at low temperature Efecto de la sequía continua y la inmersión sobre la respuesta de eclosión de los huevos de Ochlerotatus albifasciatus (Diptera: Culicidae almacenados a baja temperatura

    Directory of Open Access Journals (Sweden)

    Raúl E Campos

    2007-07-01

    Full Text Available The role of environmental factors on the hatching response of O. albifasciatus (Macquart eggs is studied by simulating winter conditions in the laboratory. The hypothesis tested was that hatching response is affected by: (1 time that eggs remain at low temperature, (2 storage conditions, and (3 acclimatization time. Eggs were stored at 5ºC in drought and immersion conditions during 7, 21, 35, 90 and 146 days, immediately after, they were acclimatized at 22ºC during 24, 72, and 168 hours, and then eggs were flooded to induce hatching. Percent of hatched eggs was analyzed with a Generalized Lineal Model with a binomial distribution. Results show that: (1 a long storage period at cold temperature and long acclimatization periods improve the hatching response; (2 storage conditions have a moderate effect on hatching, being more evident in eggs stored dry; (3 a long time of acclimatization favors the hatching response in submerged eggs more than in eggs stored dry; (4 long time at cold favors the hatching response in eggs stored dry more than in submerged eggs; (5 the hatching response of eggs that remain for a long time at low temperature is higher when the time of acclimatization is long.Se estudió el rol de los factores ambientales sobre la eclosión de los huevos de O. albifasciatus (Macquart, simulando condiciones de invierno. La hipótesis planteada fue que la respuesta de eclosión de los huevos depende de: (1 tiempo de permanencia a baja temperatura, (2 condiciones de almacenamiento, y (3 tiempo de aclimatación. Los huevos fueron almacenados a 5º C en condiciones de sequía y sumergidos durante 7, 21, 35, 90 y 146 días; luego fueron aclimatados a 22º C durante 24, 72, y 168 horas y posteriormente inundados para inducir la eclosión. El porcentaje de huevos eclosionados se analizó con un Modelo Lineal Generalizado con distribución binomial. Los resultados mostraron que: (1 largos períodos de almacenamiento en frío y largos tiempos de aclimatación mejoran la respuesta de eclosión, (2 la condición de almacenamiento tiene un efecto moderado en la eclosión, siendo más marcada en los huevos almacenados en seco; (3 tiempos prolongados de aclimatación mejoran aún más las eclosiones de los huevos sumergidos, que los almacenados en seco; (4 largo tiempo en frío mejora la eclosión de los huevos almacenados en seco, que los sumergidos; (5 los huevos que permanecieron más tiempo en frío respondieron mejor cuando el tiempo de aclimatación fue prolongado.

  11. Distribution of stable traps for thermoluminescent processes in the phosphor SrAl{sub 2}O{sub 4}: Eu{sup 2+}, Dy{sup 3+}; Distribucion de trampas continuas para procesos termoluminiscentes en el fosforo SrAl{sub 2}O{sub 4}: Eu{sup 2+}, Dy{sup 3+}

    Energy Technology Data Exchange (ETDEWEB)

    Pedroza M, M.; Castaneda, B.; Arellano T, O.; Melendrez, R.; Barboza F, M. [Universidad de Sonora, A.P. 5-088 Mexico D.F. (Mexico)

    2007-07-01

    Full text: The phosphor of persistent luminescence (PLUM) SrAl{sub 2}O{sub 4}:Eu{sup 2+}, Dy{sup 3+} exhibits one thermoluminescence curve after exposing it to UV radiation. The curve is made up of a wide band with a maximum around 455 K. Starting from the experimental deconvolution method proposed by McKeever, it was solved the number of peaks in the TL curve and it was analyzed the position of each TL peak regarding to the cut temperature (T{sub stop}). In this analysis five maximum TL peaks were observed (at the diagram T{sub stop} vs T{sub max}) around the 319, 425, 457, 488 and 515 K. Also, its were also found two regions that correspond to an overlap of stable traps, the first one in the region of the 380 K at 415 K and the second of the 430 to 455 K. The existence of a distribution of stable traps can be evaluated from the curve T{sub stop} vs T{sub max} where this distribution of stable traps is presented as a monotonous lineal increase with the temperature, because the TL independent processes appear like horizontal lines exactly in the specific temperatures (319, 425, 457, 488 and 515 K) where its are liberated most of the trapped charges. Using the preheating method and initial increase for the peak in 455 K the trap depths are determined, being obtained the following values of the activation energy 0.28, 0.67, 1, 1.5 and 1.62 eV. An arrangement of stable traps plays a decisive role in the emission of the persistent luminescence. Likewise, it was determined that all the thermoluminescent processes were characterized by a re trapping of the charge, reason by which these processes followed a second order kinetics. The TL peak of low temperature 319 K is related with those electronic traps that the PLUM takes place in SrAl{sub 2}O{sub 4}: Eu{sup 2+} and with the same recombination centers. The PLUM emissions and the TL are centered around 510 nm attributed to the electronic transition 4f{sup 6}5d{sup 1} {yields}4f{sup 7} corresponding to the Eu{sup 2+} ion. In this work, it is explained the participation or contribution of the overlapping of stable traps in the TL recombination process due to this characteristic would affect the luminescent properties of the SrAl{sub 2}O{sub 4}:Eu{sup 2+}, Dy{sup 3+}, in particular, the properties related with the thermal and optically stimulated processes. A model that includes the effect of the continuous traps and their apparent charge re trapping, as well as the regeneration of the TL process during several cycles is not complete, as well as the incorporation of some of its phenomenological characteristics are still in discussion. (Author)

  12. Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine Infusão continua em cães fêmeas submetidas à ovariohisterectomia com midazolam/cetamina/xilazina e/ou medetomidina pré-tratadas com levomepromazina e buprenorfina

    Directory of Open Access Journals (Sweden)

    Fernando do Carmo Silva

    2007-08-01

    Full Text Available PURPOSE: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality. METHODS: 20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, were assigned randomly and homogenously to 2 groups of 10 animals each (n=10, group 1 (G1 and group 2 (G2, respectively. Animals of G1 were subjected to a pre-treatment with intravenous 1.0 mg/kg methotrimeprazine and or 3ì/kg. After 15 minutes, a 5.0 mg/kg ketamine and 0.2 mg/kg midazolam were intravenously injected. Immediately after induction, an anesthetic combination of 0.4 mg/kg/h midazolam, 20 mg/kg/h ketamine and 1.0 mg/kg/h xylazine, was continuously and intravenously administered for 30 minutes. The same techniques were used in G2 except for the substitution of xylazine for 30ìg/kg/h medetomidine. RESULTS: In G1 there was a 1st and 2nd degree atrioventricular heart block, a longer recovery period and lower quality. In G2 a 1st degree atrioventricular heart block occurred but isolated and ephemeral. CONCLUSIONS: The continuous infusion method, besides reducing drugs utilization, prevented collateral effects allowing a more tranquil recovery with no excitations, both protocols permitted the surgical procedure (ovary-hysterectomy bringing about a reduction in hypnosis and an accentuated myorelaxation. Xylazine and medetomidine showed a similar pharmacodynamic behavior but with different clinical aspects. The electrocardiographic alterations observed in G2 and in a lower degree in G1 must be well studied. Describers: dogs, ketamine, methotrimeprazine, medetomidine, midazolam and xylazine.OBJETIVO: Comparar através de infusão contínua de xilazina ou medetomidina associada à metotrimeprazina e buprenorfina, cetamina e midazolam, o grau de hipnose, miorrelaxamento e qualidade anestésica e a viabilidade cirúrgica, avaliando eventuais alterações paramétricas e qualidade de recuperação. MÉTODOS: Foram utilizados 20 cães fêmeas, adultas, hígidas (3 a 5 anos de idade com peso corporal entre 7 e 15 quilos, escolhidas e distribuídas aleatoriamente de forma homogênea em 2 grupos de 10 animais cada, (n=10 sendo estes designados por Grupo 1 (G1, e Grupo 2 (G 2. Em G1, os animais foram submetidos a um pré-tratamento com metotrimeprazina na dose de 1,0 mg/kg e buprenorfina na dose de 0,003mg/kg ou 3 µg/kg intravenoso. Decorridos 15 minutos, administrou-se cetamina na dose de 5,0 mg/kg e midazolam na dose de 0,2 mg/kg intravenoso. Imediatamente após a indução iniciou-se administração contínua, por um período de 30 minutos, da associação anestésica de midazolam 0,4 mg/kg/h, cetamina 20mg/kg/h e xilazina 1,0 mg/kg/h IV. Em G 2 utilizou-se a mesma técnica empregada em G1 substituindo-se, a xilazina pela medetomidina na dose de 30µg/kg/h. RESULTADOS: Verificou-se em G1 bloqueio átrio-ventricular de primeiro e segundo grau, período de recuperação mais longo além de menor qualidade. Em G 2 observou-se bloqueio átrio-ventricular de primeiro grau isolado e de ação fugaz. CONCLUSÕES: Ao se aplicar o método de infusão contínua, além da redução dos fármacos aplicados, evitaram-se efeitos colaterais permitindo uma recuperação mais tranqüila e isenta de excitações, ambos os protocolos permitiram a realização do ato cirúrgico (ovário-salpingo-histerectomia, causando uma redução da hipnose e um miorrelaxamento acentuado. A xilazina e a medetomidina apresentam um comportamento farmacodinâmico semelhante, porém com aspectos clínicos diferentes, as alterações eletrocardiográficas observadas em G 2 e em menor grau em G1 devem ser melhor estudadas.

  13. ELECTROMAGNETIC COMPATIBILITY OF A DC POWER DISTRIBUTION SYSTEM FOR THE ATLAS LIQUID ARGON CALORIMETER COMPATIBILIDAD ELECTROMAGNÉTICA EN EL SISTEMA DE DISTRIBUCIÓN DE CORRIENTE CONTINUA PARA EL CALORÍMETRO DE ARGÓN LÍQUIDO EN ATLAS

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    George Blanchot

    2008-06-01

    Full Text Available The front-end electronics of the ATLAS Liquid Argon Calorimeter is powered by DC/DC converters nearby the front-end crates. They are fed by AC/DC converters located in a remote control room through long power cables. The stability of the power distribution scheme is compromised by the impedance of the long interconnection cable, and proper matching of the converters dynamic impedances is required. Also, the long power cable fed by a powerful AC/DC converter is a source of electromagnetic interferences in the experimental area. The optimal grounding and shielding configuration to minimize these EMI is discussed.El Calorímetro de Argón Líquido en ATLAS es alimentado por convertidores DC/DC localizados cerca de sus compartimientos. Ellos son alimentados por convertidores AC/DC localizados en una sala de control lejana conectados mediante cables largos de poder. La estabilidad del sistema de distribución es sensible a la impedancia del cable largo de interconexión y son requeridos los convertidores apropiados para estabilizar la dinámica de la impedancia. También, el cable largo alimentado por el convertidor AC/DC es una fuente de interferencia electromagnética en el área experimental. En este trabajo se analiza La óptima configuración de aterrizamiento y blindaje para minimizar los efectos de EMI.

  14. ESTRATEGIES FOR TO INTEGRATE IN A SINGLE SYSTEM THE PROCESSES OF TEACHING, LEARNING, ASSESSMENT AND MANAGEMENT TO PROMOTE CONTINUOUS IMPROVEMENTS IN ENGINEERING EDUCATION / ESTRATEGIAS PARA INTEGRAR EN UN ÚNICO SISTEMA LOS PROCESOS DE ENSEÑANZA, APRENDIZAJE, EVALUACIÓN Y GESTIÓN PARA PROMOVER MEJORAS CONTINUAS EN LA ENSEÑANZA DE LA INGENIERÍA

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    Daniel Arturo Veiga

    2013-02-01

    Full Text Available This paper describe a study developed in the Electronic Circuits Laboratory – Faculty of Engineering, University of Buenos Aires -, where learning strategies were designed and started. These strategies take into account an intensive use of computer simulation and laboratory work, analyzing its incidence on students performance in a Electronic Circuits I course (seventh semester course in electronic engineering degree. This methodology is applied in practical-theoretical courses.and includes the design of didactic materials for, from the need to solve problems, the students make decisions and interact with different referents: teachers, students, software, and bibliography. To assess the impact of this methodology, a computerized system was developed for academic management that makes it easy to obtain and to evaluate quantitative variables. In conjunction with proper tools to extract qualitative conclusions, we can develop strategies to follow, in order to promote the improvements that are considered appropriate in every moment. The analysis of the information obtained and the development of strategies to apply is the basis of the research project approved by the University of Buenos Aires to the pedagogical area.RESUMENSe describe un trabajo de investigación que se desarrolla en el Laboratorio de Circuitos Electrónicos de la Facultad de Ingeniería de la Universidad de Buenos Aires, donde se diseñan y ponen en marcha estrategias didácticas, que combinan el uso intenso de simulación y trabajos en laboratorio, analizando su incidencia en las producciones de los estudiantes que cursan la asignatura Circuitos Electrónicos I, del 7° cuatrimestre de la carrera de Ingeniería Electrónica que posee 10 cuatrimestres nominales de duración. La forma de trabajo en los cursos teórico-prácticos consiste en aplicar una metodología que incluye el diseño, elaboración y utilización de material didáctico desarrollado específicamente para que, a partir de la necesidad de resolver situaciones problemáticas, los estudiantes tomen decisiones e interactúen con distintos referentes: docentes, estudiantes, software y bibliografía. Para valorar el impacto de esta metodología, se desarrolló un sistema informático de gestión académica, que facilita la obtención y evaluación de variables cuantitativas. En conjunto con herramientas adecuadas que permiten extraer conclusiones cualitativas, se elaboran estrategias de seguimiento, con el objeto de poner en práctica las mejoras que se consideran oportunas en cada momento, ya sea desde el comienzo de cada cuatrimestre como durante el desarrollo de éste. El análisis de la información obtenida y la elaboración de las estrategias a adoptar es la base del proyecto de investigación aprobado por la Universidad de Buenos Aires para el área pedagógica.

  15. Physical modeling of steel flow in a tun dish equipped with a turbulence inhibitor and a gas curtain; Modelacion fisica del flujo de acero en un distribuidor de colada continua equipado con un inhibidor de turbulencia y una cortina de gas

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Labra, M.; Diaz-Cruz, M.; Palafox-Ramos, J.; Avila-Davila, E. O.; Patino-Cardona, F.

    2005-07-01

    A 2/5 scale model with a transparent plastic sheet was built based on Froude criterion in which eight cases were studied by PIV technique, maintaining a constant gas flow rate of 596 ml/min and only varying the gas curtain position. The results permitted to get Residence Time Distribution (RTD) curves, and from the data processing it was found that combining Turbulence Inhibitor (TI) with the adequate gas curtain position it is enhanced the plug volume. The case VII presented the best results increasing the plug volume in 131.85% in comparison with the case IV which was taken as the reference one. (Author) 10 refs.

  16. Estudio de factibilidad para la implementación de un sistema de capacitación continua apoyada en T.I. (caso de estudio personal de operación de las subestaciones eléctricas de Celec ep – Transelectric)

    OpenAIRE

    Sánchez Naranjo, María Fernanda

    2015-01-01

    El presente capítulo contiene la información necesaria sobre el uso de las TIC’s en el ámbito educativo, generándose nuevos y novedosos conceptos, necesarios para comprender el nuevo paradigma de la formación, la Educación Virtual, y lo relacionado con su entorno, ventajas, desventajas y definiciones importantes que servirán para el objeto de la presente tesis. El uso de las TIC’s se encuentra en una evolución y propagación constante y se podría decir que éstas se pueden emplear cada vez c...

  17. Síntesis de 3-ciano-4-hidroxicumarina y análisis de su equilibrio tautomérico utilizando la Teoría del Funcional de la Densidad (DFT y el modelo de solvatación continua (PCM | Synthesis of 3-cyanohydroxycoumarin and analysis of its tautomeric equilibrium using Density Functional Theory (DFT and polarizable continuum model (PCM

    Directory of Open Access Journals (Sweden)

    Gustavo Cabrera

    2017-11-01

    Full Text Available The procedure for the synthesis of 3-cyano-4-hydroxycoumarin is presented along with the results from the analysis of its tautomeric equilibrium using Density Functional Theory (DFT and Polarizable Continuum Model (PCM. The geometry of the compounds was optimized with Gaussian 03 and from the resulting structures, a group of thermodynamic and kinetic parameters were determined. It was found that 3-cyano-4-hydroxycoumarin was the most stable tautomer, as was also shown by spectroscopic techniques. Other parameters, such as: transition state energy, equlibrium constant, kinetic constant, bond orders and bond angles, were also calculated.

  18. Proposals for an effective application of the continuous improvement at the ININ according to the IAEA 50-C/SG-Q new code; Propuestas para una aplicacion efectiva del proceso de mejora continua en el ININ, de acuerdo al nuevo codigo 50-C/SG-Q del OIEA

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas A, B.M.; Olivares O, L.A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    This work contains the requirements of continuous improvement contained in the IAEA new code {sup Q}uality assurance for safety in nuclear power plants and other nuclear installations, code 50-C/SG-Q. Assuming that it was the base for to elaborate the review No. 5 of the Quality assurance plan at ININ, it was done an analysis to give proposals for the application of continuous improvement in effective way. The relevant points which must be taken in account at the continuous improvement process are: Direction responsibility, involucring of all personnel, process planning, education and training, elaboration of improvement projects, investigation of processes which can be improved, continuation of the improvement process and its evaluation. With the implantation of an effective continuous improvement system it will be obtained to get a better quality and a more efficient safety. (Author)

  19. Ca2+ signalling in endothelial progenitor cells: a novel means to improve cell-based therapy and impair tumour vascularisation.

    Science.gov (United States)

    Moccia, Francesco; Lodola, Francesco; Dragoni, Silvia; Bonetti, Elisa; Bottino, Cinzia; Guerra, Germano; Laforenza, Umberto; Rosti, Vittorio; Tanzi, Franco

    2014-01-01

    Endothelial progenitor cells (EPCs) have recently been employed in cell-based therapy (CBT) to promote regeneration of ischemic organs, such as heart and limbs. Furthermore, EPCs may sustain tumour vascularisation and provide an additional target for anticancer therapies. CBT is limited by the paucity of cells harvested from peripheral blood and suffers from several pitfalls, including the low rate of engrafted EPCs, whereas classic antiangiogenic treatments manifest a number of side effects and may induce resistance into the patients. CBT will benefit of a better understanding of the signal transduction pathway(s) which drive(s) EPC proliferation, trafficking, and incorporation into injured tissues. At the same time, this information might outline alternative molecular targets to impair tumor neovascularisation and improve the therapeutic outcome of antiangiogenic strategies. An increase in intracellular Ca(2+) concentration is the key signal in the regulation of cellular replication, migration, and differentiation. In particular, Ca(2+) signalling may regulate cellcycle progression, due to the Ca(2+)-sensitivity of a number of cycline-dependent kinases, and gene expression, owing to the Ca(2+)-dependence of several transcription factors. Recent work has outlined the role of the so-called store-operated Ca(2+) entry in driving EPC proliferation and migration. Unravelling the mechanisms guiding EPC engraftment into neovessels might supply the biological bases required to improve CBT and anticancer treatments. For example, genetic manipulation of the Ca(2+) signalling machinery could provide a novel approach to increase the extent of limb regeneration or preventing tumour vascularisation by EPCs.

  20. Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?

    Science.gov (United States)

    Yu, Cai-Guo; Zhang, Ning; Yuan, Sha-Sha; Ma, Yan; Yang, Long-Yan; Feng, Ying-Mei; Zhao, Dong

    2016-01-01

    Despite being featured as metabolic disorder, diabetic patients are largely affected by hyperglycemia-induced vascular abnormality. Accumulated evidence has confirmed the beneficial effect of endothelial progenitor cells (EPCs) in coronary heart disease. However, antivascular endothelial growth factor (anti-VEGF) treatment is the main therapy for diabetic retinopathy and nephropathy, indicating the uncertain role of EPCs in the pathogenesis of diabetic microvascular disease. In this review, we first illustrate how hyperglycemia induces metabolic and epigenetic changes in EPCs, which exerts deleterious impact on their number and function. We then discuss how abnormal angiogenesis develops in eyes and kidneys under diabetes condition, focusing on "VEGF uncoupling with nitric oxide" and "competitive angiopoietin 1/angiopoietin 2" mechanisms that are shared in both organs. Next, we dissect the nature of EPCs in diabetic microvascular complications. After we overview the current EPCs-related strategies, we point out new EPCs-associated options for future exploration. Ultimately, we hope that this review would uncover the mysterious nature of EPCs in diabetic microvascular disease for therapeutics.