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Sample records for parity showed associations

  1. [Obesity in Brazilian women: association with parity and socioeconomic status].

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    Ferreira, Regicely Aline Brandão; Benicio, Maria Helena D'Aquino

    2015-05-01

    To determine the influence of reproductive history on the prevalence of obesity in Brazilian women and the possible modifying effect of socioeconomic variables on the association between parity and excess weight. A retrospective analysis of complex sample data collected as part of the 2006 Brazilian National Survey on Demography and Health, which included a group representative of women of childbearing age in Brazil was conducted. The study included 11 961 women aged 20 to 49 years. The association between the study factor (parity) and the outcome of interest (obesity) was tested using logistic regression analysis. The adjusted effect of parity on obesity was assessed in a multiple regression model containing control variables: age, family purchasing power, as defined by the Brazilian Association of Research Enterprises (ABEP), schooling, and health care. Significance level was set at below 0.05. The prevalence of obesity in the study population was 18.6%. The effect of parity on obesity was significant (P for trend parity and age. Family purchase power had a significant odds ratio for obesity only in the unadjusted analysis. In the adjusted model, this variable did not explain obesity. The present findings suggest that parity has an influence on obesity in Brazilian women of childbearing age, with higher prevalence in women vs. without children.

  2. Association of secondary sex ratio with smoking and parity.

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    Beratis, Nicholas G; Asimacopoulou, Aspasia; Varvarigou, Anastasia

    2008-03-01

    To assess the sex ratio in offspring of smoking and nonsmoking mothers in relationship to parity. Prospective study. University hospital. The authors studied 2,108 term singleton neonates born between 1993 and 2002, 665 from smoking mothers and 1,443 from nonsmoking mothers. A prospective recording of maternal age, parity and smoking status, and gender of neonates delivered over a 10-year period. Secondary sex ratio in regard to maternal smoking and parity. The offspring sex ratio in the total sample studied was 1.09; in the offspring of smoking and nonsmoking mothers, it was 1.26 and 1.03, respectively, a statistically significant difference. In the offspring of smoking women who had parity 1, 2, and >or=3, it was 1.47, 1.35, and 0.92, whereas in those of nonsmoking women, it was 1.04, 1.00, and 1.03, respectively (the differences of the parity 1 and 2 groups between the offspring of smoking and nonsmoking mothers were statistically significant). Logistic regression analysis showed that the possibility of a boy being delivered by a mother who smoked was significantly greater in primiparous women than in women who had parity >or=3, independent of the maternal age. Conversely, parity did not affect significantly the sex ratio in the offspring of nonsmoking women. The findings suggest that among women who smoked, significantly more male than female offspring are born from primiparous women, whereas women who had parity >or=3 gave birth to more female offspring; biparous women give birth to significantly more male offspring, but the offspring sex ratio declined with the number of cigarettes when the mothers smoked >or=10 cigarettes per day.

  3. Association between parity and risk of suicide among parous women.

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    Yang, Chun-Yuh

    2010-04-06

    There are limited empirical data to support the theory of a protective effect of parenthood against suicide, as proposed by Durkheim in 1897. I conducted this study to examine whether there is an association between parity and risk of death from suicide among women. The study cohort consisted of 1,292,462 women in Taiwan who had a first live birth between Jan. 1, 1978, and Dec. 31, 1987. The women were followed up from the date of their first birth to Dec. 31, 2007. Their vital status was ascertained by means of linking records with data from a computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from suicide associated with parity. There were 2252 deaths from suicide during 32 464 187 person-years of follow-up. Suicide-related mortality was 6.94 per 100,000 person-years. After adjustment for age at first birth, marital status, years of schooling and place of delivery, the adjusted hazard ratio was 0.61 (95% confidence interval [CI] 0.54-0.68) among women with two live births and 0.40 (95% CI 0.35-0.45) among those with three or more live births, compared with women who had one live birth. I observed a significantly decreasing trend in adjusted hazard ratios of suicide with increasing parity. This study provides evidence to support Durkheim's hypothesis that parenthood confers a protective effect against suicide.

  4. Association between parity and breastfeeding with maternal high blood pressure.

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    Lupton, Samantha J; Chiu, Christine L; Lujic, Sanja; Hennessy, Annemarie; Lind, Joanne M

    2013-06-01

    The objective of this study was to determine how parity and breastfeeding were associated with maternal high blood pressure, and how age modifies this association. Baseline data for 74,785 women were sourced from the 45 and Up Study, Australia. These women were 45 years of age or older, had an intact uterus, and had not been diagnosed with high blood pressure before pregnancy. Odds ratios (ORs) and 99% confidence intervals (CIs) for the association between giving birth, breastfeeding, lifetime breastfeeding duration, and average breastfeeding per child with high blood pressure were estimated using logistic regression. The combination of parity and breastfeeding was associated with lower odds of having high blood pressure (adjusted OR, 0.89; 99% CI, 0.82-0.97; P high blood pressure when compared with parous women who never breastfed. The odds were lower with longer breastfeeding durations and were no longer significant in the majority of women over the age of 64 years. Women should be encouraged to breastfeed for as long as possible and a woman's breastfeeding history should be taken into account when assessing her likelihood of high blood pressure in later life. Copyright © 2013 Mosby, Inc. All rights reserved.

  5. Associations between parity and maternal BMI in a population-based cohort study.

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    Iversen, Ditte S; Kesmodel, Ulrik S; Ovesen, Per G

    2018-02-07

    We aimed to investigate the change in prevalence of overweight and obesity in pregnant Danish women from 2004 to 2012, and investigate whether increasing parity was associated with a change in body mass index (BMI) prevalence. We obtained a population-based cohort from the Danish Medical Birth Registry consisting of all Danish women giving birth in 2004-2012 (n = 572 321). This registry contains information on 99.8% of all births in Denmark. We calculated the overall change in prepregnancy BMI status among pregnant women in Denmark, and a multiple linear regression model with adjustment for several potential confounders was used to examine the change in prepregnancy BMI with increasing parity. In 2004, the prevalence of prepregnancy overweight and obesity (BMI ≥ 25) and obesity alone (BMI ≥ 30) was 31.9 and 11%, respectively. In 2012, the prevalence had reached 34.2 and 12.8%. The mean BMI increased for every additional parity from 23.80 (95% CI 23.77-23.82) in parity group 1 to 26.70 (26.52-26.90) in parity group 5+. A multiple linear regression adjusted for potential confounders showed that women on average gained 0.62 (0.58-0.65) BMI units after every additional birth. This study showed a 7.2% increase in overweight and obesity (BMI ≥ 25) and a 16.4% increase in obesity alone (BMI ≥ 30) for pregnant women in Denmark from 2004 to 2012. In addition, an increase in interpregnancy BMI was seen at every additional delivery, suggesting that obesity is an increasing challenge in obstetrics. © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

  6. Risk of shoulder dystocia: associations with parity and offspring birthweight. A population study of 1 914 544 deliveries.

    Science.gov (United States)

    Overland, Eva A; Vatten, Lars J; Eskild, Anne

    2012-04-01

    We estimated the associations of parity and offspring birthweight with the risk of shoulder dystocia, and studied whether the association of offspring birthweight differed by parity. Population-based register study. The Medical Birth Registry of Norway was used to identify all deliveries between 1967 and 2006. All vaginal deliveries of a singleton offspring in cephalic presentation during the period 1967-2006 (n=1,914,544). Shoulder dystocia at delivery. Shoulder dystocia occurred in 0.68% (13,109/1,914,544) of all deliveries. There was a strong positive association of birthweight with risk of shoulder dystocia, and 75% (9765/13,109) of all cases occurred in deliveries of offspring weighing 4000g or more. The association of birthweight displayed similar patterns across parities, but the association was slightly stronger in parous than in primiparous women. Among first-time mothers, 0.12% (320/276,614) with offspring weighing 3000-3499g (reference) experienced shoulder dystocia, compared with 13.30% (169/1244) with offspring birthweight higher than 5000g [odds ratio (OR) 135.7, 95%CI 111.6-165.1]. The corresponding results for women with one previous delivery were 0.08% (161/201,572) and 16.45% (501/3054) (OR 246.4, 95%CI 205.4-295.5). High offspring birthweight is the major risk factor for shoulder dystocia, constituting most cases. The positive association of birthweight with shoulder dystocia showed similar patterns across parities, but high birthweight parous women were at greater risk of shoulder dystocia compared with primiparous women. © 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.

  7. Association of Obesity, Parity, and History of Knee Injury with Knee Osteoarthritis in Female

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    Ade Triyadi

    2015-12-01

    Full Text Available Background: Osteoarthritis is the most joint disorder among elderly. There are a lot of risk factors of knee osteoarthritis. Obesity and high frequent of parity can increase the load on knee joint. Knee injury also decreases the stability of knee joint on bearing body load. This study was conducted to observe the association of obesity, parity ≥3 times and history of knee injury with the occurrence of knee osteoarthritis in female aged >50 years old. Methods: Case control design was chosen in this study. Female patients with age >50 years were recruited by consecutive sampling from rheumatology clinic at Dr. Hasan Sadikin General Hospital Bandung. Data were collected from August to September 2013. Minimal sample size was 60 samples calculated by rule of thumb formula. Obesity was measured by body mass index (BMI. Parity and history of knee injury were assessed by questionnaire. Those variables were analyzed by logistic regression method. Result: Obesity did not associate with knee osteoarthritis in this study, p=0.549 (odd ratio (OR 1.32, 95% confidence interval (CI 0.52–3.32. Parity was associated with knee osteoarthritis in this study p=0.001 (OR 4.7, 95% CI 1.89–11.68. History of knee injury was associated with knee osteoarthritis in this study, p=0.001 (OR 6.19, 95% CI 2.01–18.99. Conclusions: Parity ≥3 times and history of knee injury were associated with the occurrence of knee osteoarthritis. Obesity was not associated with the occurrence of knee osteoarthritis.

  8. Associations of parity-related reproductive histories with ER± and HER2± receptor-specific breast cancer aetiology

    DEFF Research Database (Denmark)

    Anderson, William F; Pfeiffer, Ruth M; Wohlfahrt, Jan

    2017-01-01

    ± expression. Methods: We linked a cancer registry covering nearly 95% of the primary breast cancer diagnoses in Denmark with a research parity database to assess associations for parity, number of live births and age at first live birth (AFLB) with receptor-specific risk. Relative risks (RRs) for associations...

  9. Metabolic predictors of peri-partum diseases and their association with parity in dairy cows.

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    Ruprechter, Gretel; Adrien, Maria de Lourdes; Larriestra, Alejandro; Meotti, Otavio; Batista, Chester; Meikle, Ana; Noro, Mirela

    2018-02-19

    The predictive values of plasma non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), cholesterol, albumin and calcium to predict risk of peripartum diseases in primiparous (PP) and multiparous (MP) Holstein cows was investigated. Besides it was assessed if the health status interacted with parity on body condition score and metabolic profiles during the transition period. Dairy cows (126 PP and 182 MP) from a commercial dairy free stall herd (loose-housing system) were weekly body condition scored and tail bled for metabolites determination from -3 to +4 weeks relative to calving. Peripartum diseases were diagnosed by a single trained veterinarian, while subclinical diseases (ketosis and hypocalcemia) were diagnosed at the laboratory. Cows were classified as healthy cows, cows with one event, or cows with two clinical events following a prospective observational cohort study, with only healthy cows enrolled at the beginning of the study. The largest incidence was for metritis (26.6%) followed by retained placenta (17.2%) and mastitis (15.2%) with no effect of parity, while subclinical hypocalcemia incidence was greater in MP than PP cows (43% vs 9.5%) respectively. In MP cows albumin concentrations were predictive for metritis at week -2 and for retained placenta at weeks -2 and -1, while cholesterol was predictive for mastitis at week -2, -1 and at calving. The interaction between health status and parity affected all metabolites during the transition period. This study showed a different evolution of metabolic profiles in healthy and sick cows during the transition according to parity, pointing out albumin and cholesterol as diseases predictors before calving. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Association between parity and dentition status among Japanese women: Japan public health center-based oral health study.

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    Ueno, Masayuki; Ohara, Satoko; Inoue, Manami; Tsugane, Shoichiro; Kawaguchi, Yoko

    2013-10-22

    Several studies have shown that parity is associated with oral health problems such as tooth loss and dental caries. In Japan, however, no studies have examined the association. The purpose of this study was to determine whether parity is related to dentition status, including the number of teeth present, dental caries and filled teeth, and the posterior occlusion, in a Japanese population by comparing women with men. A total of 1,211 subjects, who participated both in the Japan Public Health Center-Based (JPHC) Study Cohort I in 1990 and the dental survey in 2005, were used for the study. Information on parity or number of children was collected from a self-completed questionnaire administered in 1990 for the JPHC Study Cohort I, and health behaviors and clinical dentition status were obtained from the dental survey in 2005. The association between parity or number of children and dentition status was analyzed, by both unadjusted-for and adjusted-for socio-demographic and health behavioral factors, using a generalized linear regression model. Parity is significantly related to the number of teeth present and n-FTUs (Functional Tooth Units of natural teeth), regardless of socio-demographic and health behavioral factors, in female subjects. The values of these variables had a significantly decreasing trend with the rise of parity: numbers of teeth present (p for trend = 0.046) and n-FTUs (p for trend = 0.026). No relationships between the number of children and dentition status were found in male subjects. Higher-parity women are more likely to lose teeth, especially posterior occluding relations. These results suggest that measures to narrow the discrepancy by parity should be taken for promoting women's oral health. Delivery of appropriate information and messages to pregnant women as well as enlightenment of oral health professionals about dental management of pregnant women may be an effective strategy.

  11. Milk losses associated with somatic cell counts by parity and stage of lactation.

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    Gonçalves, Juliano L; Cue, Roger I; Botaro, Bruno G; Horst, José A; Valloto, Altair A; Santos, Marcos V

    2018-05-01

    The reduction of milk production caused by subclinical mastitis in dairy cows was evaluated through the regression of test-day milk yield on log-transformed somatic cell counts (LnSCC). Official test-day records (n = 1,688,054) of Holstein cows (n = 87,695) were obtained from 719 herds from January 2010 to December 2015. Editing was performed to ensure both reliability and consistency for the statistical analysis, and the final data set comprised 232,937 test-day records from 31,692 Holstein cows in 243 herds. A segmented regression was fitted to estimate the cutoff point in the LnSCC scale where milk yield started to be affected by mastitis. The statistical model used to explain daily milk yield included the effect of herd as a random effect and days in milk and LnSCC as fixed effects regressions, and analyses were performed by parity and stage of lactation. The cutoff point where milk yield starts to be affected by changes in LnSCC was estimated to be around 2.52 (the average of all estimates of approximately 12,400 cells/mL) for Holsteins cows from Brazilian herds. For first-lactation cows, milk losses per unit increase of LnSCC had estimates around 0.68 kg/d in the beginning of the lactation [5 to 19 d in milk (DIM)], 0.55 kg/d in mid-lactation (110 to 124 DIM), and 0.97 kg/d at the end of the lactation (289 to 304 DIM). For second-lactation cows, milk losses per unit increase of LnSCC had estimates around 1.47 kg/d in the beginning of the lactation (5 to 19 DIM), 1.09 kg/d in mid-lactation (110 to 124 DIM), and 2.45 kg/d at the end of the lactation (289 to 304 DIM). For third-lactation cows, milk losses per unit increase of LnSCC had estimates around 2.22 kg/d in the beginning of the lactation (5 to 19 DIM), 1.13 kg/d in mid-lactation (140 to 154 DIM), and 2.65 kg/d at the end of the lactation (289 to 304 DIM). Daily milk losses caused by increased LnSCC were dependent on parity and stage of lactation, and these factors should be considered when estimating

  12. Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity?

    DEFF Research Database (Denmark)

    Bliddal, Mette; Pottegård, Anton; Kirkegaard, Helene

    Background Obesity among women may influence the risk of degenerative musculoskeletal conditions (MSCs) and contribute to poor quality of life. Parity, which constitutes a sudden natural increase in weight as well it affects long-term body mass index (BMI), may put strain on the musculoskeletal....... Information on height and weight prior to pregnancy was obtained from telephone interviews and parity from the Danish Medical Birth Registry. Diagnoses on degenerative MSC including osteoarthritis, disc disorders, low back pain, and soft tissue disorders were obtained from the National Patient Registry......% confidence interval 1.41-1.83]). Conclusions High pre-pregnancy BMI increased the occurrence of degenerative MSC in the years following pregnancy and childbirth. In combination with increasing pre-pregnancy BMI, higher parity added to an already elevated risk. Prevention of maternal overweight may reduce...

  13. The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis

    Science.gov (United States)

    2013-01-01

    Background Previous studies have reported on adverse neonatal outcomes associated with parity and maternal age. Many of these studies have relied on cross-sectional data, from which drawing causal inference is complex. We explore the associations between parity/maternal age and adverse neonatal outcomes using data from cohort studies conducted in low- and middle-income countries (LMIC). Methods Data from 14 cohort studies were included. Parity (nulliparous, parity 1-2, parity ≥3) and maternal age (gestational-age (SGA), preterm, neonatal and infant mortality. Adjusted odds ratios (aOR) were calculated per study and meta-analyzed. Results Nulliparous, age mothers, suggesting that reproductive health interventions need to address the entirety of a woman’s reproductive period. Funding Funding was provided by the Bill & Melinda Gates Foundation (810-2054) by a grant to the US Fund for UNICEF to support the activities of the Child Health Epidemiology Reference Group. PMID:24564800

  14. Parity mixing

    International Nuclear Information System (INIS)

    Adelberger, E.G.

    1975-01-01

    The field of parity mixing in light nuclei bears upon one of the exciting and active problems of physics--the nature of the fundamental weak interaction. It is also a subject where polarization techniques play a very important role. Weak interaction theory is first reviewed to motivate the parity mixing experiments. Two very attractive systems are discussed where the nuclear physics is so beautifully simple that the experimental observation of tiny effects directly measures parity violating (PV) nuclear matrix elements which are quite sensitive to the form of the basic weak interaction. Since the measurement of very small analyzing powers and polarizations may be of general interest to this conference, some discussion is devoted to experimental techniques

  15. The Hamiltonian structures of the super KP hierarchy associated with an even parity superlax operator

    International Nuclear Information System (INIS)

    Barcelos Neto, J.; Ghosh, S.; Roy, S.

    1993-07-01

    We consider the even parity superLax operator for the supersymmetric KP hierarchy of the form L = D 2 + Σ ∞ i=0 u i-2 D -i+1 and obtain the two Hamiltonian structures following the standard method of Gelfand and Dikii. We observe that the first Hamiltonian structure is local and linear whereas the second Hamiltonian structure is non-local and nonlinear among the superfields appearing in the Lax operator. We discuss briefly on their connections with the super ω ∞ algebra. (author). 23 refs

  16. Parity horizons in shape dynamics

    International Nuclear Information System (INIS)

    Herczeg, Gabriel

    2016-01-01

    I introduce the notion of a parity horizon, and show that many simple solutions of shape dynamics possess them. I show that the event horizons of the known asymptotically flat black hole solutions of shape dynamics are parity horizons and that this notion of parity implies that these horizons possess a notion of CPT invariance that can in some cases be extended to the solution as a whole. I present three new solutions of shape dynamics with parity horizons and find that not only do event horizons become parity horizons in shape dynamics, but observer-dependent horizons and Cauchy horizons do as well. The fact that Cauchy horizons become (singular) parity horizons suggests a general chronology protection mechanism in shape dynamics that prevents the formation of closed timelike curves. (paper)

  17. Anaemia in pregnancy: associations with parity, abortions and child spacing in primary healthcare clinic attendees in Trinidad and Tobago.

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    Uche-Nwachi, E O; Odekunle, A; Jacinto, S; Burnett, M; Clapperton, M; David, Y; Durga, S; Greene, K; Jarvis, J; Nixon, C; Seereeram, R; Poon-King, C; Singh, R

    2010-03-01

    To determine the prevalence of anaemia in antenatal clinic attendees; to investigate the effects of parity, age, gravidity, previous abortions, child spacing and other factors on the prevalence of anaemia in pregnancy. This was a retrospective and cross-sectional study. Antenatal records of 2287 pregnant women attending 40 public healthcare centres from January 2000 to December 2005 in Trinidad and Tobago were used. Data pertaining to the investigated variables were recorded. The national prevalence of anaemia was calculated and chi-square tests, odds ratios and logistic regression were used to assess the relationship between anaemia and each variable. The prevalence of anaemia was 15.3% (95% CI 13.4%, 16.6%). No significant difference in the prevalence of anaemia was found among the different clinics or counties. At the first haemoglobin reading, age was inversely related to the presence of anaemia, whereas gestational age at first visit was directly related. At the final haemoglobin reading, parity, gravidity, and previous spontaneous abortions were directly related to the prevalence of anaemia, while the number of visits was inversely related. Age was inversely associated to the severity of anaemia while gravidity was directly related. The prevalence of anaemia decreased by 18.7% from 1967. Despite this positive indication, women under 24 years and those commencing antenatal care after the first trimester are still at a higher risk for developing anaemia. Early commencement of antenatal care and close monitoring of the risk groups identified should be strongly advocated.

  18. Sociodemographic factors and pregnancy outcomes associated with prepregnancy obesity: effect modification of parity in the nationwide Epifane birth-cohort.

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    Boudet-Berquier, Julie; Salanave, Benoit; Desenclos, Jean-Claude; Castetbon, Katia

    2017-08-25

    In light of the adverse outcomes for mothers and offspring related to maternal obesity, identification of subgroups of women at risk of prepregnancy obesity and its related-adverse issues is crucial for optimizing antenatal care. We aimed to identify sociodemographic factors and maternal and neonatal outcomes associated with prepregnancy obesity, and we tested the effect modification of parity on these associations. In 2012, 3368 mothers who had delivered in 136 randomly selected maternity wards were included just after birth in the French birth cohort, Epifane. Maternal height and weight before and at the last month of pregnancy were self-reported. Maternal and neonatal outcomes were collected in medical records. Prepregnancy Body Mass Index (pBMI) was classified into underweight (pregnancy outcomes was stratified on parity (1335 primiparous and 1814 multiparous). Before pregnancy, 7.6% of women were underweight, 64.2% were of normal weight, 18.0% were overweight and 10.2% were obese. Among the primiparous, maternal age of 25-29 years (OR = 2.09 [1.13-3.87]; vs. 30-34 years), high school level (OR = 2.22 [1.33-3.73]; vs. university level), gestational diabetes (OR = 2.80 [1.56-5.01]) and hypertensive complications (OR = 3.80 [1.83-7.89]) were independently associated with prepregnancy obesity. Among the multiparous, primary (OR = 6.30 [2.40-16.57]), junior high (OR = 2.89 [1.81-4.64]) and high school (OR = 1.86 [1.18-2.93]) education levels (vs. university level), no attendance at antenatal classes (OR = 1.77 [1.16-2.72]), excess gestational weight gain (OR = 1.82 [1.20-2.76]), gestational diabetes (OR =5.16 [3.15-8.46]), hypertensive complications (OR = 8.13 [3.97-16.64]), caesarean delivery (OR = 1.80 [1.18-2.77]) and infant birth weight ≥ 4 kg (OR = 1.70 [1.03-2.80]; vs. birth weight between 2.5 kg and 4 kg) were independently associated with prepregnancy obesity. Obesity before pregnancy is associated with a set of

  19. The association between parity, infant gender, higher level of paternal education and preterm birth in Pakistan: a cohort study

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    Shaikh Kiran

    2011-11-01

    Full Text Available Abstract Background High rates of antenatal depression and preterm birth have been reported in Pakistan. Self reported maternal stress and depression have been associated with preterm birth; however findings are inconsistent. Cortisol is a biological marker of stress and depression, and its measurement may assist in understanding the influence of self reported maternal stress and depression on preterm birth. Methods In a prospective cohort study pregnant women between 28 to 30 weeks of gestation from the Aga Khan Hospital for Women and Children completed the A-Z Stress Scale and the Centre for Epidemiology Studies Depression Scale to assess stress and depression respectively, and had a blood cortisol level drawn. Women were followed up after delivery to determine birth outcomes. Correlation coefficients and Wilcoxon rank sum test was used to assess relationship between preterm birth, stress, depression and cortisol. Logistic regression analysis was used to determine the key factors predictive of preterm birth. Results 132 pregnant women participated of whom 125 pregnant women had both questionnaire and cortisol level data and an additional seven had questionnaire data only. Almost 20% of pregnant women (19·7%, 95% CI 13·3-27·5 experienced a high level of stress and nearly twice as many (40·9%, 95% CI 32·4-49·8% experienced depressive symptoms. The median of cortisol level was 27·40 ug/dl (IQR 22·5-34·2. The preterm birth rate was 11·4% (95% CI 6·5-18. There was no relationship between cortisol values and stress scale or depression. There was a significant positive relationship between maternal depression and stress. Preterm birth was associated with higher parity, past delivery of a male infant, and higher levels of paternal education. Insufficient numbers of preterm births were available to warrant the development of a multivariable logistic regression model. Conclusions Preterm birth was associated with higher parity, past delivery

  20. The association between parity, infant gender, higher level of paternal education and preterm birth in Pakistan: a cohort study.

    Science.gov (United States)

    Shaikh, Kiran; Premji, Shahirose S; Rose, Marianne S; Kazi, Ambreen; Khowaja, Shaneela; Tough, Suzanne

    2011-11-02

    High rates of antenatal depression and preterm birth have been reported in Pakistan. Self reported maternal stress and depression have been associated with preterm birth; however findings are inconsistent. Cortisol is a biological marker of stress and depression, and its measurement may assist in understanding the influence of self reported maternal stress and depression on preterm birth. In a prospective cohort study pregnant women between 28 to 30 weeks of gestation from the Aga Khan Hospital for Women and Children completed the A-Z Stress Scale and the Centre for Epidemiology Studies Depression Scale to assess stress and depression respectively, and had a blood cortisol level drawn. Women were followed up after delivery to determine birth outcomes. Correlation coefficients and Wilcoxon rank sum test was used to assess relationship between preterm birth, stress, depression and cortisol. Logistic regression analysis was used to determine the key factors predictive of preterm birth. 132 pregnant women participated of whom 125 pregnant women had both questionnaire and cortisol level data and an additional seven had questionnaire data only. Almost 20% of pregnant women (19·7%, 95% CI 13·3-27·5) experienced a high level of stress and nearly twice as many (40·9%, 95% CI 32·4-49·8%) experienced depressive symptoms. The median of cortisol level was 27·40 ug/dl (IQR 22·5-34·2). The preterm birth rate was 11·4% (95% CI 6·5-18). There was no relationship between cortisol values and stress scale or depression. There was a significant positive relationship between maternal depression and stress. Preterm birth was associated with higher parity, past delivery of a male infant, and higher levels of paternal education. Insufficient numbers of preterm births were available to warrant the development of a multivariable logistic regression model. Preterm birth was associated with higher parity, past delivery of a male infant, and higher levels of paternal education. There

  1. Winning Cores in Parity Games

    DEFF Research Database (Denmark)

    Vester, Steen

    2016-01-01

    We introduce the novel notion of winning cores in parity games and develop a deterministic polynomial-time under-approximation algorithm for solving parity games based on winning core approximation. Underlying this algorithm are a number properties about winning cores which are interesting...... in their own right. In particular, we show that the winning core and the winning region for a player in a parity game are equivalently empty. Moreover, the winning core contains all fatal attractors but is not necessarily a dominion itself. Experimental results are very positive both with respect to quality...

  2. Magic state parity-checker with pre-distilled components

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    Earl T. Campbell

    2018-03-01

    Full Text Available Magic states are eigenstates of non-Pauli operators. One way of suppressing errors present in magic states is to perform parity measurements in their non-Pauli eigenbasis and postselect on even parity. Here we develop new protocols based on non-Pauli parity checking, where the measurements are implemented with the aid of pre-distilled multiqubit resource states. This leads to a two step process: pre-distillation of multiqubit resource states, followed by implementation of the parity check. These protocols can prepare single-qubit magic states that enable direct injection of single-qubit axial rotations without subsequent gate-synthesis and its associated overhead. We show our protocols are more efficient than all previous comparable protocols with quadratic error reduction, including the protocols of Bravyi and Haah.

  3. Associations between pregnancy-associated glycoproteins and pregnancy outcomes, milk yield, parity, and clinical diseases in high-producing dairy cows.

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    Mercadante, P M; Ribeiro, E S; Risco, C; Ealy, A D

    2016-04-01

    Pregnancy-associated glycoproteins (PAG) are produced by the ruminant placenta and secreted into the maternal circulation throughout pregnancy. The extent to which circulating PAG concentrations predict pregnancy outcomes was examined herein. Also, associations between circulating PAG concentrations and various production parameters and clinical diseases were evaluated. Lactating primiparous and multiparous Holstein cows (n=345) were bred via timed artificial insemination using a standard Ovsynch protocol. Pregnancy was diagnosed by transrectal ultrasonography at d 32, 46, and 74 of gestation. Blood was harvested at d 32 to determine plasma concentrations of PAG and progesterone. Cows pregnant at d 32 that subsequently lost their pregnancy at d 46 and 74 had reduced PAG concentrations. Both artificial insemination service number and parity were associated with plasma PAG concentrations. Concentration of PAG in plasma was greater for cows pregnant from their second or later breeding than those pregnant from the first breeding postpartum, and was increased for primiparous compared with multiparous. In addition, cows with greater milk yield had increased plasma PAG concentrations. No association was detected between body condition score and plasma PAG concentrations. Cows that experienced clinical metritis, metabolic problems, or left displacement abomasum in the early postpartum period preceding breeding had greater plasma PAG concentrations than cows not experiencing these clinical diseases. Also, cows with multiple clinical diseases had increased odds of pregnancy loss when compared with cows not experiencing clinical diseases. Odds ratio testing detected a tendency in the relationship between reduced milk yield and increased pregnancy loss. Collectively, these associations illustrate one feature of the early developing placenta that may predict pregnancy outcomes in dairy cattle. It is unclear if plasma PAG are actively involved with mediating pregnancy outcomes

  4. A single nucleotide polymorphism in the zona pellucida 3 gene is associated with the first parity litter size in Hu sheep.

    Science.gov (United States)

    Chong, Yuqing; Huang, Huarong; Liu, Guiqiong; Jiang, Xunping; Rong, Weiheng

    2018-03-31

    Zona pellucida 3 (ZP3) is a primary sperm receptor and acrosome reaction inducer. As a candidate gene, the ZP3 gene has been widely studied since it has great influence on reproductive traits in farm animals. However, little is known about the association between polymorphisms of the coding region of the ZP3 gene and the first parity litter size in Hu sheep. Therefore, the objective of this study was to identify single nucleotide polymorphisms (SNPs) of the ZP3 gene associated with the first parity litter size in Hu sheep. A total of 462 female Hu sheep were sampled to detect SNPs in the coding region of the ZP3 gene. Six SNPs were identified and the reliability of all estimated allele frequencies reached 0.9545 except for one locus (g.2293C > T). SNP (rs401271989) was identified as that involved in amino acid change (Ile → Leu). This amino acid was located at the beginning of a β-strand and outside of the ZP3 protein membrane, and it was most likely to be a ligand-binding site (the possibility was 0.917). At this locus, individuals with AC genotype had a larger litter size than those with CC genotype in the first parity (2.050 vs 1.727, p size in Hu sheep, and it may affect the function of ZP3 protein by impacting the secondary and tertiary protein structures. The present study demonstrates that SNP (rs401271989) could be used in marker-assisted selection of the first parity litter size in Hu sheep. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Human placental immunoglobulins show unique re-association ...

    African Journals Online (AJOL)

    Objective: To study re-association pattern of human placental eluate immunoglobulins with acid treated isologous and third party trophoblast derived placental microvesicles. Design: Laboratory based experimentation. Setting: Biological Sciences Department and Discipline for Reproductive Medicine University of ...

  6. Parity and the Risk of Type 2 Diabetes

    DEFF Research Database (Denmark)

    Ovesen, Per; Ipsen, Sidsel; Lundbye-Christensen, Søren

    year 2004 and information on type, date, interval from birth to diagnosis of diabetes was recorded. A total of 1717 cases were diagnosed with diabetes in the follow-up period of 23 yearswhich ich correspond to 1,7%. The women in the study were between 13 and 50 years old at the time of delivery. We...... grouped the study population in age groups: the young (age 13-22 years) comprising 19% of the total births, middle group (23-29 years) comprising 55% of the births and old group (30-50 years) comprising 26% of the births. In all groups there was a significant effect of parity on the development......  The relationship between parity and diabetes has been discussed for many years and the subject is still controversial.  Some investigations show that parity, particularly five or more births, might be associated with higher incidence of diabetes, whereas others found no association. We performed...

  7. A cure for stuttering parity games

    NARCIS (Netherlands)

    Cranen, S.; Keiren, J.J.A.; Willemse, T.A.C.; Roychoudhury, A.; D'Souza, M.

    2012-01-01

    We define governed stuttering bisimulation for parity games, weakening stuttering bisimulation by taking the ownership of vertices into account only when this might lead to observably different games. We show that governed stuttering bisimilarity is an equivalence for parity games and allows for a

  8. A cure for stuttering parity games

    NARCIS (Netherlands)

    Cranen, S.; Keiren, J.J.A.; Willemse, T.A.C.

    2012-01-01

    We de¿ne governed stuttering bisimulation for parity games, weakening stuttering bisimulation by taking the ownership of vertices into account only when this might lead to observably different games. We show that governed stuttering bisimilarity is an equivalence for parity games and allows for a

  9. Weak NNM couplings and nuclear parity violation

    International Nuclear Information System (INIS)

    Holstein, B.R.

    1987-01-01

    After many years of careful theoretical and experimental study of nuclear parity violation, rough empirical values for weak parity violation nucleon-nucleon-meson vertices have been deduced. We address some of the physics which has been learned from this effort and show that it has implications for work going on outside this field. (author)

  10. Supersymmetric models without R parity

    International Nuclear Information System (INIS)

    Ross, G.G.; Valle, J.W.F.

    1985-01-01

    We show that many supersymmetric models may spontaneously break R parity through scalar neutrinos acquiring a vacuum expectation value (vev). These models allow supersymmetric particles to be produced singly and to decay to nonsupersymmetric states. This leads to a new pattern of supersymmetric phenomenology. We discuss the lepton number violation to be expected in this class of models. (orig.)

  11. Odd-parity light baryon resonances

    International Nuclear Information System (INIS)

    Gamermann, D.; Garcia-Recio, C.; Salcedo, L. L.; Nieves, J.

    2011-01-01

    We use a consistent SU(6) extension of the meson-baryon chiral Lagrangian within a coupled channel unitary approach in order to calculate the T matrix for meson-baryon scattering in the s wave. The building blocks of the scheme are the π and N octets, the ρ nonet and the Δ decuplet. We identify poles in this unitary T matrix and interpret them as resonances. We study here the nonexotic sectors with strangeness S=0, -1, -2, -3 and spin J=(1/2), (3/2) and (5/2). Many of the poles generated can be associated with known N, Δ, Σ, Λ, Ξ and Ω resonances with negative parity. We show that most of the low-lying three and four star odd-parity baryon resonances with spin (1/2) and (3/2) can be related to multiplets of the spin-flavor symmetry group SU(6). This study allows us to predict the spin-parity of the Ξ(1620), Ξ(1690), Ξ(1950), Ξ(2250), Ω(2250) and Ω(2380) resonances, which have not been determined experimentally yet.

  12. Fall of parity

    International Nuclear Information System (INIS)

    Forman, P.

    1982-01-01

    The historical background behind the discovery of the violation of parity by T. D. Lee and [N. Yand is described. The experimental techniques used by Chien-Shiung Wu, Ernst Ambler, and their collaborators at the Cryogenic Physics Laboratory of the NBS to first demonstrate the violation of parity are also described

  13. Polarized protons and parity violating asymmetries

    International Nuclear Information System (INIS)

    Trueman, T.L.

    1984-01-01

    The potential for utilizing parity violating effects, associated with polarized protons, to study the standard model, proton structure, and new physics at the SPS Collider is summarized. 24 references

  14. Grid parity: the quest for the Grail

    International Nuclear Information System (INIS)

    Bahjejian, L.

    2012-01-01

    The cost of photovoltaic systems is decreasing and the price of electrical power is increasing, so at one moment the 2 curves will meet and at that moment there will be grid parity, it means that the photovoltaic power will be as competitive as other energies and will need no more subsidies. In Denmark the electricity is so expensive that the grid parity has already been reached and photovoltaic power is developing there on the basis of net metering. According to the EPIA (European Association for Photovoltaic Industry), France, Germany, Italy, Spain and United-Kingdom will reach grid parity by 2020. (A.C.)

  15. Purchasing power parity and interest parity in the laboratory

    OpenAIRE

    Fisher, Eric O'N.

    2001-01-01

    This paper analyzes purchasing power parity and uncovered interest parity in the laboratory. It finds strong evidence that purchasing power parity, covered interest parity, and uncovered interest parity hold. Subjects are endowed with an intrinsically useless (green) currency that can be used to purchase another useless (red) currency. Green goods can be bought only with green currency, and red goods can be bought only with red currency. The foreign exchange markets are organized as call mark...

  16. Linking high parity and maternal and child mortality: what is the impact of lower health services coverage among higher order births?

    Science.gov (United States)

    Sonneveldt, Emily; DeCormier Plosky, Willyanne; Stover, John

    2013-01-01

    A number of data sets show that high parity births are associated with higher child mortality than low parity births. The reasons for this relationship are not clear. In this paper we investigate whether high parity is associated with lower coverage of key health interventions that might lead to increased mortality. We used DHS data from 10 high fertility countries to examine the relationship between parity and coverage for 8 child health intervention and 9 maternal health interventions. We also used the LiST model to estimate the effect on maternal and child mortality of the lower coverage associated with high parity births. Our results show a significant relationship between coverage of maternal and child health services and birth order, even when controlling for poverty. The association between coverage and parity for maternal health interventions was more consistently significant across countries all countries, while for child health interventions there were fewer overall significant relationships and more variation both between and within countries. The differences in coverage between children of parity 3 and those of parity 6 are large enough to account for a 12% difference in the under-five mortality rate and a 22% difference in maternal mortality ratio in the countries studied. This study shows that coverage of key health interventions is lower for high parity children and the pattern is consistent across countries. This could be a partial explanation for the higher mortality rates associated with high parity. Actions to address this gap could help reduce the higher mortality experienced by high parity birth.

  17. Leverage Aversion and Risk Parity

    DEFF Research Database (Denmark)

    Asness, Clifford; Frazzini, Andrea; Heje Pedersen, Lasse

    2012-01-01

    The authors show that leverage aversion changes the predictions of modern portfolio theory: Safer assets must offer higher risk-adjusted returns than riskier assets. Consuming the high risk-adjusted returns of safer assets requires leverage, creating an opportunity for investors with the ability...... to apply leverage. Risk parity portfolios exploit this opportunity by equalizing the risk allocation across asset classes, thus overweighting safer assets relative to their weight in the market portfolio....

  18. Associations between Parity, Hair Hormone Profiles during Pregnancy and Lactation, and Infant Development in Rhesus Monkeys (Macaca mulatta.

    Directory of Open Access Journals (Sweden)

    Amanda M Dettmer

    Full Text Available Studies examining hormones throughout pregnancy and lactation in women have been limited to single, or a few repeated, short-term measures of endocrine activity. Furthermore, potential differences in chronic hormonal changes across pregnancy/lactation between first-time and experienced mothers are not well understood, especially as they relate to infant development. Hormone concentrations in hair provide long-term assessments of hormone production, and studying these measures in non-human primates allows for repeated sampling under controlled conditions that are difficult to achieve in humans. We studied hormonal profiles in the hair of 26 female rhesus monkeys (Macaca mulatta, n=12 primiparous, to determine the influences of parity on chronic levels of cortisol (hair cortisol concentration, HCC and progesterone (hair progesterone concentration, HPC during early- to mid-pregnancy (PREG1, in late pregnancy/early lactation (PREG2/LACT1, and in peak lactation (LACT2. We also assessed infants' neurobehavioral development across the first month of life. After controlling for age and stage of pregnancy at the first hair sampling period, we found that HCCs overall peaked in PREG2/LACT1 (p=0.02, but only in primiparous monkeys (p<0.001. HPCs declined across pregnancy and lactation for all monkeys (p<0.01, and primiparous monkeys had higher HPCs overall than multiparous monkeys (p=0.02. Infants of primiparous mothers had lower sensorimotor reflex scores (p=0.02 and tended to be more irritable (p=0.05 and less consolable (p=0.08 in the first month of life. Moreover, across all subjects, HCCs in PREG2/LACT1 were positively correlated with irritability (r(s=0.43, p=0.03 and negatively correlated with sensorimotor scores (r(s=-0.41, p=0.04. Together, the present results indicate that primiparity influences both chronic maternal hormonal profiles and infant development. These effects may, in part, reflect differential reproductive and maternal effort in

  19. The nondiscovery of parity nonconservation

    International Nuclear Information System (INIS)

    Franklin, A.

    1989-01-01

    Although experiments in 1928 and 1930 provided evidence for the nonconservation of parity in the weak interactions, it was not until weak interactions were needed in the 1950s to match experiment to theory that these were re-examined. After describing the two experiments and their results, the author concludes that while errors existed, the early works did show parity nonconservation, but their contemporaries in the scientific community rejected their evidence, partly because the theoretical framework to explain it did not yet exist. High energy electron beams meant that experiments reproducing earlier work on beta decay were unlikely to be repeated and because the difference between thermion, C and decay electrons was not then understood. (UK)

  20. Leptogenesis from R parity non-conservation

    Energy Technology Data Exchange (ETDEWEB)

    Hambye, T. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati, Frascati, RM (Italy); Ma, E. [Riverside Univ. of California, Riverside, CA (United States). Dept. of Physics; Sarkar, U. [Physical Research Laboratory, Ahmedabad (India)

    2000-07-01

    It is known that realistic neutrino masses for neutrino oscillations may be obtained from R parity nonconserving supersymmetry. It is also known that such interactions would erase any preexisting lepton or baryon asymmetry of the Universe because of the inevitable intervention of the electroweak sphalerons. It is showed how a crucial subset of these R parity nonconserving terms may in fact create its own successful leptogenesis.

  1. Leptogenesis from R parity non-conservation

    International Nuclear Information System (INIS)

    Hambye, T.; Ma, E.

    2000-01-01

    It is known that realistic neutrino masses for neutrino oscillations may be obtained from R parity nonconserving supersymmetry. It is also known that such interactions would erase any preexisting lepton or baryon asymmetry of the Universe because of the inevitable intervention of the electroweak sphalerons. It is showed how a crucial subset of these R parity nonconserving terms may in fact create its own successful Leptogenesis

  2. Absolute purchasing power parity in industrial countries

    OpenAIRE

    Zhang, Zhibai; Bian, Zhicun

    2015-01-01

    Different from popular studies that focus on relative purchasing power parity, we study absolute purchasing power parity (APPP) in 21 main industrial countries. Three databases are used. Both the whole period and the sub-period are analyzed. The empirical proof shows that the phenomenon that APPP holds is common, and the phenomenon that APPP does not hold is also common. In addition, some country pairs and the pooled country data indicate that the nearer the GDPPs of two countries are, the mo...

  3. Efficient Parallel Strategy Improvement for Parity Games

    OpenAIRE

    Fearnley, John

    2017-01-01

    We study strategy improvement algorithms for solving parity games. While these algorithms are known to solve parity games using a very small number of iterations, experimental studies have found that a high step complexity causes them to perform poorly in practice. In this paper we seek to address this situation. Every iteration of the algorithm must compute a best response, and while the standard way of doing this uses the Bellman-Ford algorithm, we give experimental results that show that o...

  4. No parity anomaly in massless QED3: A BPHZL approach

    International Nuclear Information System (INIS)

    Del Cima, O.M.; Franco, D.H.T.; Piguet, O.; Schweda, M.

    2009-01-01

    In this Letter we call into question the perturbatively parity breakdown at 1-loop for the massless QED 3 frequently claimed in the literature. As long as perturbative quantum field theory is concerned, whether a parity anomaly owing to radiative corrections exists or not shall be definitely proved by using a renormalization method independent of any regularization scheme. Such a problem has been investigated in the framework of BPHZL renormalization method, by adopting the Lowenstein-Zimmermann subtraction scheme. The 1-loop parity-odd contribution to the vacuum-polarization tensor is explicitly computed in the framework of the BPHZL renormalization method. It is shown that a Chern-Simons term is generated at that order induced through the infrared subtractions - which violate parity. We show then that, what is called 'parity anomaly', is in fact a parity-odd counterterm needed for restauring parity.

  5. Electron scattering violates parity

    CERN Multimedia

    2004-01-01

    Parity violation has been observed in collisions between electrons at the Stanford Linear Accelerator Center (SLAC) in the US. The resuls, which are in agreement with the Stanford Model of particle physics, also provide a new measurement of the weak charge of the electron (½ page)

  6. Parity violating electron scattering

    International Nuclear Information System (INIS)

    McKeown, R.D.

    1990-01-01

    Previous measurements of parity violation in electron scattering are reviewed with particular emphasis on experimental techniques. Significant progress in the attainment of higher precision is evident in these efforts. These pioneering experiments provide a basis for consideration of a future program of such measurements. In this paper some future plans and possibilities in this field are discussed

  7. Mental Health Insurance Parity and Provider Wages.

    Science.gov (United States)

    Golberstein, Ezra; Busch, Susan H

    2017-06-01

    Policymakers frequently mandate that employers or insurers provide insurance benefits deemed to be critical to individuals' well-being. However, in the presence of private market imperfections, mandates that increase demand for a service can lead to price increases for that service, without necessarily affecting the quantity being supplied. We test this idea empirically by looking at mental health parity mandates. This study evaluated whether implementation of parity laws was associated with changes in mental health provider wages. Quasi-experimental analysis of average wages by state and year for six mental health care-related occupations were considered: Clinical, Counseling, and School Psychologists; Substance Abuse and Behavioral Disorder Counselors; Marriage and Family Therapists; Mental Health Counselors; Mental Health and Substance Abuse Social Workers; and Psychiatrists. Data from 1999-2013 were used to estimate the association between the implementation of state mental health parity laws and the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act and average mental health provider wages. Mental health parity laws were associated with a significant increase in mental health care provider wages controlling for changes in mental health provider wages in states not exposed to parity (3.5 percent [95% CI: 0.3%, 6.6%]; pwages. Health insurance benefit expansions may lead to increased prices for health services when the private market that supplies the service is imperfect or constrained. In the context of mental health parity, this work suggests that part of the value of expanding insurance benefits for mental health coverage was captured by providers. Given historically low wage levels of mental health providers, this increase may be a first step in bringing mental health provider wages in line with parallel health professions, potentially reducing turnover rates and improving treatment quality.

  8. Adverse perinatal outcomes associated with moderate or severe maternal anaemia based on parity in Finland during 2006-10.

    Science.gov (United States)

    Räisänen, Sari; Kancherla, Vijaya; Gissler, Mika; Kramer, Michael R; Heinonen, Seppo

    2014-09-01

    Anaemia during pregnancy is an important public health problem. We investigated whether the association between maternal anaemia during pregnancy and adverse perinatal outcomes differed between nulliparous and multiparous women. A retrospective population-based cohort study was conducted using data on all singleton births (n = 290 662) recorded in the Finnish Medical Birth Register during 2006-10. Maternal anaemia was defined as a maternal haemoglobin level of anaemia and adverse outcomes was assessed by logistic regression analysis. The prevalence of anaemia during pregnancy was 2.5% among nulliparous women and 2.3% among multiparous women. Among nulliparous women, anaemia was not associated with adverse perinatal outcomes. Among multiparous women, anaemia was associated with preterm delivery (adjusted odds ratio [aOR] 1.32, [95% CI 1.14, 1.53]), SGA (aOR 1.27, [95% CI 1.04, 1.55]), and admission to neonatal intensive care (aOR 1.23, [95% CI 1.10, 1.38]); there was a trend towards increased odds of major congenital anomalies (aOR 1.15, [95% CI 0.99, 1.34]). These data underscore that maternal anaemia is associated with several adverse perinatal outcomes. This association was, however, confined to multiparous women. Future research should explore in detail the timing of anaemia in these associations. © 2014 John Wiley & Sons Ltd.

  9. Symbolic Detection of Permutation and Parity Symmetries of Evolution Equations

    KAUST Repository

    Alghamdi, Moataz

    2017-06-18

    We introduce a symbolic computational approach to detecting all permutation and parity symmetries in any general evolution equation, and to generating associated invariant polynomials, from given monomials, under the action of these symmetries. Traditionally, discrete point symmetries of differential equations are systemically found by solving complicated nonlinear systems of partial differential equations; in the presence of Lie symmetries, the process can be simplified further. Here, we show how to find parity- and permutation-type discrete symmetries purely based on algebraic calculations. Furthermore, we show that such symmetries always form groups, thereby allowing for the generation of new group-invariant conserved quantities from known conserved quantities. This work also contains an implementation of the said results in Mathematica. In addition, it includes, as a motivation for this work, an investigation of the connection between variational symmetries, described by local Lie groups, and conserved quantities in Hamiltonian systems.

  10. Parity anomalies in gauge theories in 2 + 1 dimensions

    International Nuclear Information System (INIS)

    Rao, S.; Yahalom, R.

    1986-01-01

    We show that the introduction of massless fermions in an abelian gauge theory in 2+1 dimensions does not lead to any parity anomaly despite a non-commutativity of limits in the structure function of the odd part of the vacuum polarization tensor. However, parity anomaly does exist in non-abelian theories due to a conflict between gauge invariance under large gauge transformations and the parity symmetry. 6 refs

  11. Nuclear Parity with China?

    Science.gov (United States)

    2012-01-01

    nuclear force structure. It even is conceivable that a slow but steady expansion could have been accomplished without triggering a reaction by...Russia’s reactions , which would likely not be benign. • Achieving nuclear parity is not a matter of honor for China. Chinese leaders never have...analyzes that information, defines its interests, and decides how to act. China and the United States are exact opposites in this typography : China

  12. Reconsidering solar grid parity

    International Nuclear Information System (INIS)

    Yang, C.-J.

    2010-01-01

    Grid parity-reducing the cost of solar energy to be competitive with conventional grid-supplied electricity-has long been hailed as the tipping point for solar dominance in the energy mix. Such expectations are likely to be overly optimistic. A realistic examination of grid parity suggests that the cost-effectiveness of distributed photovoltaic (PV) systems may be further away than many are hoping for. Furthermore, cost-effectiveness may not guarantee commercial competitiveness. Solar hot water technology is currently far more cost-effective than photovoltaic technology and has already reached grid parity in many places. Nevertheless, the market penetration of solar water heaters remains limited for reasons including unfamiliarity with the technologies and high upfront costs. These same barriers will likely hinder the adoption of distributed solar photovoltaic systems as well. The rapid growth in PV deployment in recent years is largely policy-driven and such rapid growth would not be sustainable unless governments continue to expand financial incentives and policy mandates, as well as address regulatory and market barriers.

  13. Real interest parity decomposition

    Directory of Open Access Journals (Sweden)

    Alex Luiz Ferreira

    2009-09-01

    Full Text Available The aim of this paper is to investigate the general causes of real interest rate differentials (rids for a sample of emerging markets for the period of January 1996 to August 2007. To this end, two methods are applied. The first consists of breaking the variance of rids down into relative purchasing power pariety and uncovered interest rate parity and shows that inflation differentials are the main source of rids variation; while the second method breaks down the rids and nominal interest rate differentials (nids into nominal and real shocks. Bivariate autoregressive models are estimated under particular identification conditions, having been adequately treated for the identified structural breaks. Impulse response functions and error variance decomposition result in real shocks as being the likely cause of rids.O objetivo deste artigo é investigar as causas gerais dos diferenciais da taxa de juros real (rids para um conjunto de países emergentes, para o período de janeiro de 1996 a agosto de 2007. Para tanto, duas metodologias são aplicadas. A primeira consiste em decompor a variância dos rids entre a paridade do poder de compra relativa e a paridade de juros a descoberto e mostra que os diferenciais de inflação são a fonte predominante da variabilidade dos rids; a segunda decompõe os rids e os diferenciais de juros nominais (nids em choques nominais e reais. Sob certas condições de identificação, modelos autorregressivos bivariados são estimados com tratamento adequado para as quebras estruturais identificadas e as funções de resposta ao impulso e a decomposição da variância dos erros de previsão são obtidas, resultando em evidências favoráveis a que os choques reais são a causa mais provável dos rids.

  14. Relationship between parity and bone mass in postmenopausal women according to number of parities and age.

    Science.gov (United States)

    Heidari, Behzad; Heidari, Parnaz; Nourooddini, Haj Ghorban; Hajian-Tilaki, Karim Ollah

    2013-01-01

    To investigate the impact of multiple pregnancies on postmenopausal bone mineral density (BMD). BMD at the femoral neck (FN) and lumbar spine (LS) was measured by dual energy X-ray absorptiometry (DXA) method. Diagnosis of osteoporosis (OP) was confirmed by World Health Organization criteria. Women were stratified according to number of parity as 7 parity groups as well as in age groups of or = 65 years. BMD values and frequency of OP were compared across the groups according to age. Multiple logistic regression analysis with calculation of adjusted odds ratio (OR) was used for association. A total of 264 women with mean age of 63 +/- 8.7 and mean menopausal duration of 15.8 +/- 10.2 years were studied. LS-OP and FN-OP were observed in 28% and 58.3% of women, respectively. There were significant differences in BMD values across different parity groups at both sites of LS and FN (p = 0.011 and p = 0.036, respectively). Parity 4-7 (vs. 7 significantly decreased LS-BMD and FN-BMD as compared with 0-7 parity (p = 0.006 and p = 0.009, respectively). Parity > 7 increased the risk of LS-OP by OR = 1.81 (95% CI 1.03-3.1, p = 0.037) and FN-OP by OR = 1.67 (95% CI 0.97-2.8, p = 0.063). In addition, women with high parity had lower BMD decline at LS and FN by age (> or = 65 vs. 7 is associated with spinal trabecular bone loss in younger postmenopausal women as well as an osteoprotective effect against age-related bone loss, which counteracts the early negative effect. Therefore, parity should not be considered as a risk factor for postmenopausal osteoporosis.

  15. The effect of parity on cause-specific mortality among married men and women.

    Science.gov (United States)

    Jaffe, Dena H; Eisenbach, Zvi; Manor, Orly

    2011-04-01

    The objective of this study was to examine mortality differentials among men and women by parity for deaths from cardio-vascular disease (CVD), cancer and other causes. The census-based Israel Longitudinal Mortality Study II (1995-2004) was used to identify 71,733 married men and 62,822 married women (45-89 years). During the 9-year follow-up period, 19,347 deaths were reported. Cox proportional hazard models adjusted for age, origin, and social class were used. A non-linear association between parity and CVD mortality was detected for men and women. Excess CVD mortality risks were observed among middle-aged women with no children (hazard ratio [HR] 2.43, 95% confidence interval [CI] 1.49, 3.96) and among middle-aged women and men with 8+ children (HR(women) 1.64, CI 1.02, 2.65; HR(men) 1.40, CI 1.01, 1.93) compared to those with two children. No clear pattern of association between cancer mortality and parity was apparent for men. Elderly women with 8+ children showed reduced mortality risks from reproductive cancers (HR 0.22, CI 0.05, 0.91). Similar parity-related mortality patterns were observed for men and women for deaths from CVD and other causes indicating biosocial pathways. The association between parity and cancer mortality differed by gender, age and type of cancer.

  16. Parents' Child Care Experience: Effects of Sex and Parity.

    Science.gov (United States)

    Gilpin, Andrew R.; Glanville, Bradley B.

    1985-01-01

    Surveyed 94 couples to determine effects on child care experience associated with gender, parity, and various other demographic variables. As expected, women had higher scores than men. Experience was a linear function of parity for men, but not for women, and was unrelated to attitudes toward women. Implications for child care responsibility are…

  17. From hadronic parity violation to electron parity-violating experiments

    International Nuclear Information System (INIS)

    Oers, Willem T.H. van

    2010-01-01

    The weak interaction is manifested in parity-violating observables. With the weak interaction extremely well known parity-violating measurements in hadronic systems can be used to deduce strong interaction effects in those systems. Parity-violating analyzing powers in electron-proton scattering have led to determining the strange quark contributions to the charge and magnetization distributions of the nucleon. Parity-violating electron-proton and electron-electron scattering can also be performed to test the predictions of the Standard Model in the 'running' of the electroweak mixing angle or sin 2 θ W .

  18. Effects of seasonal change and parity on raw milk composition and related indices in Chinese Holstein cows in northern China.

    Science.gov (United States)

    Yang, L; Yang, Q; Yi, M; Pang, Z H; Xiong, B H

    2013-01-01

    This study was to investigate the effects of seasonal change and parity on milk composition and related indices, and to analyze the relationships among milk indices in Chinese Holstein cows from an intensive dairy farm in northern China. The 6,520 sets of complete Dairy Herd Improvement data were obtained and grouped by natural month and parity. The data included daily milk yield (DMY), milk solids percentage (MSP), milk fat percentage (MFP), milk protein percentage (MPP), milk lactose percentage (MLP), somatic cell count (SCC), somatic cell score (SCS), milk production loss (MPL), and fat-to-protein ratio (FPR). Data analysis showed that the above 9 indices were affected by both seasonal change and parity. However, the interaction between parity and seasonal change showed effects on MLP, SCS, MPL, and DMY, but no effects on MFP, MPP, MSP, and FPR. Duncan's multiple comparison on seasonal change showed that DMY (23.58 kg/d), MSP (12.35%), MPP (3.02%), and MFP (3.81%) were the lowest in June, but SCC (288.7 × 10(3)/mL) and MPL (0.69 kg/d) were the lowest in January; FPR (1.32) was the highest in February. Meanwhile, Duncan's multiple comparison on parities showed that MSP, MPP, and MLP were reduced rapidly in the fourth lactation, but SCC and MPL increased with increasing parities. The canonical correlation analysis for indices showed that SCS had high positive correlation with MPL (0.8360). Therefore, a few models were developed to quantify the effects of seasonal change and parity on raw milk composition using the Wood model. The changing patterns of milk composition and related indices in different months and parities could provide scientific evidence for improving feeding management and nutritional supplementation of Chinese Holstein cows. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  19. Parity violation in neutron resonances

    International Nuclear Information System (INIS)

    Mitchell, G.E.; Lowie, L.Y.; Bowman, J.D.; Knudson, J.; Crawford, B.E.; Delheij, P.P.J.; Haseyama, T.; Masaike, A.; Matsuda, Y.; Masuda, Y.

    1997-01-01

    The observation of very large parity violation in neutron resonances has led to a new approach to the study of symmetry breaking in nuclei. The origin of the enhancement of parity violation is discussed, as well as the new (statistical) analysis approach. The TRIPLE experimental system and analysis methods, their improvements are described. Sign correlation and results from recent parity violation experiments are presented and discussed. (author)

  20. Study of positive-parity yrast band in 83Rb

    International Nuclear Information System (INIS)

    Ganguly, S.; Banerjee, P.; Ray, I.; Kshetri, R.; Bhattacharya, S.; Saha Sarkar, M.; Goswami, A.; Muralithar, S.; Singh, R.P.; Kumar, R.; Bhowmik, R.K.

    2005-01-01

    The properties of the positive-parity yrast band in the odd-A 81,83,85 Rb (Z=37) isotopes show remarkable changes as N increases. The objective of the present work is to study the structure of the lowest positive-parity band in 83 Rb from lifetime studies

  1. Parity violation in nuclei

    International Nuclear Information System (INIS)

    Robertson, R.G.H.

    1980-01-01

    A summary of parity violating effects in nuclei is given. Thanks to vigorous experimental and theoretical effort, it now appears that a reasonably well-defined value for the weak isovector π-nucleon coupling constant can be obtained. There is one major uncertainty in the analysis, namely the M2/E1 mixing ratio for the 2.79 MeV transition in 21 Ne. This quantity is virtually impossible to calculate reliably and must be measured. If it turns out to be much larger than 1, then a null result in 21 Ne is expected no matter what the weak interaction, so an experimental determination is urgently needed. The most promising approach is perhaps a measurement of the pair internal conversion coefficient. Of course, a direct measurement of a pure isovector case is highly desirable, and it is to be hoped that the four ΔT = 1 experiments will be pushed still further, and that improved calculations will be made for the 6 Li case. Nuclear parity violation seems to be rapidly approaching an interesting and useful synthesis

  2. Parity and Overweight/Obesity in Peruvian Women.

    Science.gov (United States)

    Huayanay-Espinoza, Carlos A; Quispe, Renato; Poterico, Julio A; Carrillo-Larco, Rodrigo M; Bazo-Alvarez, Juan Carlos; Miranda, J Jaime

    2017-10-19

    The rise in noncommunicable diseases and their risk factors in developing countries may have changed or intensified the effect of parity on obesity. We aimed to assess this association in Peruvian women using data from a nationally representative survey. We used data from Peru's Demographic and Health Survey, 2012. Parity was defined as the number of children ever born to a woman. We defined overweight as having a body mass index (BMI, kg/m 2 ) of 25.0 to 29.9 and obesity as a BMI ≥30.0. Generalized linear models were used to evaluate the association between parity and BMI and BMI categories, by area of residence and age, adjusting for confounders. Data from 16,082 women were analyzed. Mean parity was 2.25 (95% confidence interval [CI], 2.17-2.33) among rural women and 1.40 (95% CI, 1.36-1.43) among urban women. Mean BMI was 26.0 (standard deviation, 4.6). We found evidence of an association between parity and BMI, particularly in younger women; BMI was up to 4 units higher in rural areas and 2 units higher in urban areas. An association between parity and BMI categories was observed in rural areas as a gradient, being highest in younger women. We found a positive association between parity and overweight/obesity. This relationship was stronger in rural areas and among younger mothers.

  3. Nonlinear parity readout with a microwave photodetector

    Science.gov (United States)

    Schöndorf, M.; Wilhelm, F. K.

    2018-04-01

    Robust high-fidelity parity measurement is an important operation in many applications of quantum computing. In this work we show how in a circuit QED architecture, one can measure parity in a single shot at very high contrast by taking advantage of the nonlinear behavior of a strongly driven microwave cavity coupled to one or multiple qubits. We work in a nonlinear dispersive regime treated in an exact dispersive transformation. We show that appropriate tuning of experimental parameters leads to very high contrast in the cavity and therefore to a high-efficiency parity readout with a microwave photon counter or another amplitude detector. These tuning conditions are based on nonlinearity and are hence more robust than previously described linear tuning schemes. In the first part of the paper we show in detail how to achieve this for two-qubit parity measurements and extend this to N qubits in the second part of the paper. We also study the quantum nondemolition character of the protocol.

  4. Parity and increased risk of insulin resistance in postmenopausal women: the 2010 Korean National Health and Nutrition Examination Survey.

    Science.gov (United States)

    Kim, Jin Hwi; Lee, Sung Jong

    2017-07-01

    The objective of this study was to assess the association between parity and insulin resistance in nondiabetic, postmenopausal women. This cross-sectional study was conducted using data from the 2010 Korean National Health and Nutrition Examination Survey administered by the Korean Ministry of Health and Welfare. A total of 1,243 nondiabetic postmenopausal women were included in this study and subdivided into three groups according to parity (1-2, 3-4, and ≥5 live births). Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR) index. The relationship between parity and insulin resistance was investigated using analysis of covariance. HOMA-IR showed a positive relationship with parity. Mean HOMA-IR (geometric mean and 95% CI) increased according to increasing parity group (1-2, 3-4, and ≥5 live births) after adjustment for age, smoking, alcohol consumption, exercise, education, income, and body mass index as follows: 2.1 (2.0-2.2) insulin resistance was accompanied by obesity. The mean parity of the obese and insulin-resistant group was significantly higher than that of the nonobese insulin-sensitive group (3.6 ± 0.1 vs 3.2 ± 0.1, P = 0.047). Our study provides the first evidence that parity is significantly associated with insulin resistance in nondiabetic postmenopausal women. Further prospective longitudinal studies are needed to confirm the impact of parity on insulin resistance.

  5. R-parity breaking phenomenology

    International Nuclear Information System (INIS)

    Vissani, F.

    1996-02-01

    We review various features of the R-parity breaking phenomenology, with particular attention to the low energy observables, and to the patterns of the R-parity breaking interactions that arise in Grand Unified models. (author). 22 refs, 1 fig., 3 tabs

  6. Charge parity exotic mesons

    International Nuclear Information System (INIS)

    Burden, C.J.

    1998-01-01

    Full text: Evidence for a meson with exotic quantum numbers J PC 1 -+ , the ρ(1405), has been observed at the AGS at Brookhaven and Crystal Barrel at CERN. This meson is exotic to the extent that its quantum numbers are not consistent with the generalised Pauli exclusion principle applied to the naive constituent quark model. In a fully relativistic field theoretic treatment, however, there is nothing in principle to preclude the existence of charge parity exotics. Using our earlier covariant Bethe-Salpeter model of light-quark mesons with no new parameter fitting we demonstrate the existence of a q - q-bar bound state with the quantum numbers of the ρ

  7. R-parity violating supersymmetry

    CERN Document Server

    Barbier, R.; Besancon, M.; Chemtob, M.; Deandrea, A.; Dudas, E.; Fayet, Pierre; Lavignac, S.; Moreau, G.; Perez, E.; Sirois, Y.

    2004-01-01

    The possible appearance of R-parity violating couplings, and hence implicitly the question of lepton and baryon number conservation, has been emphasised since the early development of supersymmetric theories. The rich phenomenology implied by R-parity violation has now gained full attention in the search for supersymmetry. In this review, theoretical and phenomenological implications of R-parity violation in supersymmetric theories are discussed, in relation with particle and astroparticle physics. Fundamental aspects include the relation with continuous and discrete symmetries, up to more recent developments on the Abelian family symmetries and hierarchy of R-parity violating couplings. The question of the generation of the standard model neutrino masses and mixings is presented. The possible contributions of R-parity violating Yukawa couplings in processes involving virtual supersymmetric particles and the resulting constraints are reviewed. Finally, a survey of the direct production of supersymmetric parti...

  8. Systemic sclerosis, birth order and parity.

    Science.gov (United States)

    Russo, Paul A J; Lester, Susan; Roberts-Thomson, Peter J

    2014-06-01

    A recent study identified increasing birth order to be a risk factor for the development of systemic sclerosis (SSc). This finding supports the theory that transplacental microchimerism may be a key pathological event in the initiation of SSc. We investigated the relationship between birth order and parity and the age of onset of SSc in South Australia. A retrospective analysis of patient data in the South Australian Scleroderma Register was performed. Data were obtained from a mailed questionnaire. Control data was collected prospectively using a similar questionnaire. The relationship between birth order, family size or parity and risk of subsequent development of SSc was analyzed by mixed effects logistic regression analysis. Three hundred and eighty-seven index probands were identified and compared with 457 controls. Controls were well matched for gender, but not for age. No statistically significant relationship was identified between SSc and birth order, parity in females, family size, age at first pregnancy in females or gender of first child in parous females. Our data suggests that parity, age at first pregnancy and the gender of the first child are not relevant factors in our understanding of the epidemiology and pathogenesis of SSc. Birth order and family size in both genders also appears irrelevant. These results argue against microchimerism as being relevant in the pathogenesis of SSc and add further support to the theory that stochastic events may be important in the etiopathogenesis of SSc. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  9. Parity violation experiments at RHIC

    International Nuclear Information System (INIS)

    Tannenbaum, M.J.

    1993-01-01

    With longitudinally polarized protons at RHIC, even a 1 month dedicated run utilizing both approved major detectors could produce a significant search for new physics in hadron collisions via parity violation. Additionally, in the energy range of RHIC, large ''conventional'' parity violating effects are predicted due to the direct production of the weak bosons W ± and Z 0 . One can even envision measurements of the spin dependent sea-quark structure functions of nucleons using the single-spin parity violating asymmetry of W ± and Z 0

  10. Parity and age at menopause in a Danish sample

    DEFF Research Database (Denmark)

    Jeune, B

    1986-01-01

    A random sample of 151 Danish women who had undergone natural menopause reported the age at which this occurred and answered a questionnaire. A significant association was found between parity and age at menopause after correction for the effects of age at the first and last births, weight, smoking...... and occupation. However, there is no evidence that the age at menopause has fallen in recent decades, even though the average parity in developed populations has dropped dramatically over this period. It is therefore possible that potential fertility is a confounding variable in the relationship between parity...... and age at menopause....

  11. Parity-Time Symmetric Photonics

    KAUST Repository

    Zhao, Han; Feng, Liang

    2018-01-01

    The establishment of non-Hermitian quantum mechanics (such as parity-time (PT) symmetry) stimulates a paradigmatic shift for studying symmetries of complex potentials. Owing to the convenient manipulation of optical gain and loss in analogy

  12. Parity at the Planck scale

    Science.gov (United States)

    Arzano, Michele; Gubitosi, Giulia; Magueijo, João

    2018-06-01

    We explore the possibility that well known properties of the parity operator, such as its idempotency and unitarity, might break down at the Planck scale. Parity might then do more than just swap right and left polarized states and reverse the sign of spatial momentum k: it might generate superpositions of right and left handed states, as well as mix momenta of different magnitudes. We lay down the general formalism, but also consider the concrete case of the Planck scale kinematics governed by κ-Poincaré symmetries, where some of the general features highlighted appear explicitly. We explore some of the observational implications for cosmological fluctuations. Different power spectra for right handed and left handed tensor modes might actually be a manifestation of deformed parity symmetry at the Planck scale. Moreover, scale-invariance and parity symmetry appear deeply interconnected.

  13. The Purchasing Power Parity Hypothesis:

    African Journals Online (AJOL)

    2011-10-02

    Oct 2, 2011 ... reject the unit root hypothesis in real exchange rates may simply be due to the shortness ..... Violations of Purchasing Power Parity and Their Implications for Efficient ... Official Intervention in the Foreign Exchange Market:.

  14. Exposure to teasing on popular television shows and associations with adolescent body satisfaction.

    Science.gov (United States)

    Eisenberg, Marla E; Ward, Ellen; Linde, Jennifer A; Gollust, Sarah E; Neumark-Sztainer, Dianne

    2017-12-01

    This study uses a novel mixed methods design to examine the relationship between incidents of teasing in popular television shows and body satisfaction of adolescent viewers. Survey data were used to identify 25 favorite television shows in a large population-based sample of Minnesota adolescents (N=2793, age=14.4years). Data from content analysis of teasing incidents in popular shows were linked to adolescent survey data. Linear regression models examined associations between exposure to on-screen teasing in adolescents' own favorite shows and their body satisfaction. Effect modification by adolescent weight status was tested using interaction terms. Teasing on TV was common, with 3.3 incidents per episode; over one-quarter of teasing was weight/shape-related. Exposure to weight/shape-related teasing (β=-0.43, p=0.008) and teasing with overweight targets (β=-0.03, p=0.02) was inversely associated with girls' body satisfaction; no associations were found for boys. Findings were similar regardless of the adolescent viewer's weight status. Families, health care providers, media literacy programs and the entertainment industry are encouraged to consider the negative effects exposure to weight stigmatization can have on adolescent girls. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Parity violation in the compound nucleus

    International Nuclear Information System (INIS)

    Bowman, J.D.; Frankle, C.M.; Green, A.A.

    1994-01-01

    The status of parity violation in the compound nucleus is reviewed. The results of previous experimental results obtained by scattering polarized epithermal neutrons from heavy nuclei in the 3-p and 4-p p-wave strength function peaks are presented. Experimental techniques are presented. The extraction of the mean squared matrix element of the parity-violating interaction, M 2 , between compound-nuclear levels and the relationship of M 2 to the coupling strengths in the meson exchange weak nucleon-nucleon potential are discussed. The tendency of measured asymmetries to have a common sign and theoretical implications are discussed. New experimental results are presented that show that the common sign phenomenon is not universal, as theoretical models developed up to now would predict

  16. Psychoacoustic Tinnitus Loudness and Tinnitus-Related Distress Show Different Associations with Oscillatory Brain Activity

    Science.gov (United States)

    Balkenhol, Tobias; Wallhäusser-Franke, Elisabeth; Delb, Wolfgang

    2013-01-01

    Background The phantom auditory perception of subjective tinnitus is associated with aberrant brain activity as evidenced by magneto- and electroencephalographic studies. We tested the hypotheses (1) that psychoacoustically measured tinnitus loudness is related to gamma oscillatory band power, and (2) that tinnitus loudness and tinnitus-related distress are related to distinct brain activity patterns as suggested by the distinction between loudness and distress experienced by tinnitus patients. Furthermore, we explored (3) how hearing impairment, minimum masking level, and (4) psychological comorbidities are related to spontaneous oscillatory brain activity in tinnitus patients. Methods and Findings Resting state oscillatory brain activity recorded electroencephalographically from 46 male tinnitus patients showed a positive correlation between gamma band oscillations and psychoacoustic tinnitus loudness determined with the reconstructed tinnitus sound, but not with the other psychoacoustic loudness measures that were used. Tinnitus-related distress did also correlate with delta band activity, but at electrode positions different from those associated with tinnitus loudness. Furthermore, highly distressed tinnitus patients exhibited a higher level of theta band activity. Moreover, mean hearing loss between 0.125 kHz and 16 kHz was associated with a decrease in gamma activity, whereas minimum masking levels correlated positively with delta band power. In contrast, psychological comorbidities did not express significant correlations with oscillatory brain activity. Conclusion Different clinically relevant tinnitus characteristics show distinctive associations with spontaneous brain oscillatory power. Results support hypothesis (1), but exclusively for the tinnitus loudness derived from matching to the reconstructed tinnitus sound. This suggests to preferably use the reconstructed tinnitus spectrum to determine psychoacoustic tinnitus loudness. Results also support

  17. No parity anomaly in massless QED{sub 3}: A BPHZL approach

    Energy Technology Data Exchange (ETDEWEB)

    Del Cima, O.M. [Universidade Federal Fluminense (UFF), Polo Universitario de Rio das Ostras (PURO), Departamento de Ciencia e Tecnologia, Rua Recife s/n, 28890-000, Rio das Ostras, RJ (Brazil)], E-mail: wadodelcima@if.uff.br; Franco, D.H.T. [Universidade Federal de Vicosa (UFV), Departamento de Fisica - Campus Universitario, Avenida Peter Henry Rolfs s/n, 36570-000, Vicosa, MG (Brazil)], E-mail: dhtfranco@gmail.com; Piguet, O. [Universidade Federal do Espirito Santo (UFES), CCE, Departamento de Fisica, Campus Universitario de Goiabeiras, 29060-900, Vitoria, ES (Brazil)], E-mail: opiguet@pq.cnpq.br; Schweda, M. [Institut fuer Theoretische Physik, Technische Universitaet Wien (TU-Wien), Wiedner Hauptstrasse 8-10, A-1040, Vienna (Austria)], E-mail: mschweda@tph.tuwien.ac.at

    2009-09-14

    In this Letter we call into question the perturbatively parity breakdown at 1-loop for the massless QED{sub 3} frequently claimed in the literature. As long as perturbative quantum field theory is concerned, whether a parity anomaly owing to radiative corrections exists or not shall be definitely proved by using a renormalization method independent of any regularization scheme. Such a problem has been investigated in the framework of BPHZL renormalization method, by adopting the Lowenstein-Zimmermann subtraction scheme. The 1-loop parity-odd contribution to the vacuum-polarization tensor is explicitly computed in the framework of the BPHZL renormalization method. It is shown that a Chern-Simons term is generated at that order induced through the infrared subtractions - which violate parity. We show then that, what is called 'parity anomaly', is in fact a parity-odd counterterm needed for restauring parity.

  18. The NRP1 migraine risk variant shows evidence of association with menstrual migraine.

    Science.gov (United States)

    Pollock, Charmaine E; Sutherland, Heidi G; Maher, Bridget H; Lea, Rodney A; Haupt, Larisa M; Frith, Alison; Anne MacGregor, E; Griffiths, Lyn R

    2018-04-18

    In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine are individually or collectively associated with menstrual migraine (MM). Genotyping of migraine susceptibility SNPs was conducted using the Agena MassARRAY platform on DNA samples from 235 women diagnosed with menstrual migraine as per International Classification for Headache Disorders II (ICHD-II) criteria and 140 controls. Alternative genotyping methods including restriction fragment length polymorphism, pyrosequencing and Sanger sequencing were used for validation. Statistical analysis was performed using PLINK and SPSS. Genotypes of 34 SNPs were obtained and investigated for their potential association with menstrual migraine. Of these SNPs, rs2506142 located near the neuropilin 1 gene (NRP1), was found to be significantly associated with menstrual migraine (p = 0.003). Genomic risk scores were calculated for all 34 SNPs as well as a subset of 7 SNPs that were nearing individual significance. Overall, this analysis suggested these SNPs to be weakly predictive of MM, but of no prognostic or diagnostic value. Our results suggest that NRP1 may be important in the etiology of MM. It also suggests some genetic commonality between common migraine subtypes (MA and MO) and MM. The identification of associated SNPs may be the starting point to a better understanding of how genetic factors may contribute to the menstrual migraine sub-type.

  19. Iron-Based Superconductors as Odd-Parity Superconductors

    Directory of Open Access Journals (Sweden)

    Jiangping Hu

    2013-07-01

    Full Text Available Parity is a fundamental quantum number used to classify a state of matter. Materials rarely possess ground states with odd parity. We show that the superconducting state in iron-based superconductors is classified as an odd-parity s-wave spin-singlet pairing state in a single trilayer FeAs/Se, the building block of the materials. In a low-energy effective model constructed on the Fe square bipartite lattice, the superconducting order parameter in this state is a combination of an s-wave normal pairing between two sublattices and an s-wave η pairing within the sublattices. The state has a fingerprint with a real-space sign inversion between the top and bottom As/Se layers. The results suggest that iron-based superconductors are a new quantum state of matter, and the measurement of the odd parity can help to establish high-temperature superconducting mechanisms.

  20. Chirality and gravitational parity violation.

    Science.gov (United States)

    Bargueño, Pedro

    2015-06-01

    In this review, parity-violating gravitational potentials are presented as possible sources of both true and false chirality. In particular, whereas phenomenological long-range spin-dependent gravitational potentials contain both truly and falsely chiral terms, it is shown that there are models that extend general relativity including also coupling of fermionic degrees of freedom to gravity in the presence of torsion, which give place to short-range truly chiral interactions similar to that usually considered in molecular physics. Physical mechanisms which give place to gravitational parity violation together with the expected size of the effects and their experimental constraints are discussed. Finally, the possible role of parity-violating gravity in the origin of homochirality and a road map for future research works in quantum chemistry is presented. © 2015 Wiley Periodicals, Inc.

  1. Parity nonconservation and nuclear polarizabilities

    International Nuclear Information System (INIS)

    Haxton, W.

    1990-01-01

    The hadronic weak interaction contributes to parity nonconserving observables in semileptonic interactions. Weak nuclear polarizabilities are frequently important in such interactions. Some of the interesting physics is illustrated by 18 F, a nucleus that provides an important constraint on the neutral weak hadronic current. One observable where the nuclear polarizability is expected to dominate is the nuclear anapole moment. The long-range pion contribution to this weak radiative correction is explored for both nucleons and nuclei. Similar polarizabilities that arise for time-reversal-odd hadronic interactions that conserve or violate parity are discussed in connection with atomic electric dipole moments. 20 refs., 4 figs

  2. Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice.

    Science.gov (United States)

    Urzua, Ulises; Chacon, Carlos; Lizama, Luis; Sarmiento, Sebastián; Villalobos, Pía; Kroxato, Belén; Marcelain, Katherine; Gonzalez, María-Julieta

    2017-10-01

    Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and parity on the systemic inflammation markers that are particularly relevant to OC initiation and progression at menopause remain largely unknown. Herein, we profiled a panel of circulating cytokines in multiparous versus virgin C57BL/6 female mice at peri-estropausal age and investigated how cytokine levels were modulated by intraperitoneal tumor induction in a syngeneic immunocompetent OC mouse model. Serum FSH, LH and TSH levels increased with age in both groups while prolactin (PRL) was lower in multiparous respect to virgin mice, a finding previously observed in parous women. Serum CCL2, IL-10, IL-5, IL-4, TNF-α, IL1-β and IL-12p70 levels increased with age irrespective of parity status, but were specifically reduced following OC tumor induction only in multiparous mice. Animals developed hemorrhagic ascites and tumor implants in the omental fat band and other intraperitoneal organs by 12 weeks after induction, with multiparous mice showing a significantly extended survival. We conclude that previous parity history counteracts aging-associated systemic inflammation possibly by reducing the immunosuppression that typically allows tumor spread. Results suggest a partial impairment of the M2 shift in tumor-associated macrophages as well as decreased stimulation of regulatory B-cells in aged mice. This long term, tumor-concurrent effect of parity on inflammation markers at menopause would be a contributing factor leading to decreased OC risk.

  3. Effect of high parity on occurrence of anemia in pregnancy: a cohort study

    Directory of Open Access Journals (Sweden)

    Cabral Howard J

    2011-01-01

    Full Text Available Abstract Background Studies that explore the controversial association between parity and anaemia-in-pregnancy (AIP were often hampered by not distinguishing incident cases caused by pregnancy from prevalent cases complicated by pregnancy. The authors' aim in conducting this study was to overcome this methodological concern. Methods A retrospective cohort study was conducted in Oman on 1939 pregnancies among 479 parous female participants with available pregnancy records in a community trial. We collected information from participants, the community trial, and health records of each pregnancy. Throughout the follow-up period, we enumerated 684 AIP cases of which 289 (42.2% were incident cases. High parity (HP, ≥ 5 pregnancies accounted for 48.7% of total pregnancies. Two sets of regression analyses were conducted: the first restricted to incident cases only, and the second inclusive of all cases. The relation with parity as a dichotomy and as multiple categories was examined for each set; multi-level logistic regression (MLLR was employed to produce adjusted models. Results In the fully adjusted MLLR models that were restricted to incident cases, women with HP pregnancies had a higher risk of AIP compared to those who had had fewer pregnancies (Risk Ratio, RR = 2.92; 95% CI 2.02, 4.59; the AIP risk increased in a dose-response fashion over multiple categories of parity. In the fully adjusted MLLR models that included all cases, the association disappeared (RR = 1.11; 95% CI 0.91, 1.18 and the dose-response pattern flattened. Conclusions This study shows the importance of specifying which cases of AIP are incident and provides supportive evidence for a causal relation between parity and occurrence of incidental AIP.

  4. Permutation parity machines for neural synchronization

    International Nuclear Information System (INIS)

    Reyes, O M; Kopitzke, I; Zimmermann, K-H

    2009-01-01

    Synchronization of neural networks has been studied in recent years as an alternative to cryptographic applications such as the realization of symmetric key exchange protocols. This paper presents a first view of the so-called permutation parity machine, an artificial neural network proposed as a binary variant of the tree parity machine. The dynamics of the synchronization process by mutual learning between permutation parity machines is analytically studied and the results are compared with those of tree parity machines. It will turn out that for neural synchronization, permutation parity machines form a viable alternative to tree parity machines

  5. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

    Directory of Open Access Journals (Sweden)

    Angelo Scuteri

    2007-07-01

    Full Text Available The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of recent advances in gene-mapping technology, we executed a genome-wide association scan to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia. Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight. Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 x10(-7, hip circumference (p = 3.4 x 10(-8, and weight (p = 9.1 x 10(-7. In Sardinia, homozygotes for the rare "G" allele of this SNP (minor allele frequency = 0.46 were 1.3 BMI units heavier than homozygotes for the common "A" allele. Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 x 10(-6. Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12 were 1.8 BMI units heavier than homozygotes for the common "G" allele. To replicate our findings, we genotyped these two SNPs in the GenNet study. In European Americans (N = 1,496 and in Hispanic Americans (N = 839, we replicated significant association between rs9930506 in the FTO gene and BMI (p-value for meta-analysis of European American and Hispanic American follow-up samples, p = 0.001, weight (p = 0.001, and hip circumference (p = 0.0005. We did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although we found that in European Americans, Hispanic Americans, and African Americans, homozygotes for the rare "A" allele were, on average, 1.0-3.0 BMI units heavier than homozygotes for the more common "G" allele. In summary, we have completed a whole genome-association scan for

  6. The relationship between parity and overweight varies with household wealth and national development.

    Science.gov (United States)

    Kim, Sonia A; Yount, Kathryn M; Ramakrishnan, Usha; Martorell, Reynaldo

    2007-02-01

    Recent studies support a positive relationship between parity and overweight among women of developing countries; however, it is unclear whether these effects vary by household wealth and national development. Our objective was to determine whether the association between parity and overweight [body mass index (BMI) > or =25 kg/m(2)] in women living in developing countries varies with levels of national human development and/or household wealth. We used data from 28 nationally representative, cross-sectional surveys conducted between 1996 and 2003 (n = 275 704 women, 15-49 years). The relationship between parity and overweight was modelled using logistic regression, controlling for several biological and sociodemographic factors and national development, as reflected by the United Nations' Human Development Index. We also modelled the interaction between parity and national development, and the three-way interaction between parity, household wealth and national development. Parity had a weak, positive association with overweight, which varied by household wealth and national development. Among the poorest women and women in the second tertile of household wealth, parity was positively related to overweight only in the most developed countries. Among the wealthiest women, parity was positively related to overweight regardless of the level of national development. As development increases, the burden of parity-related overweight shifts to include poor as well as wealthy women. In the least-developed countries, programmes to prevent parity-related overweight should target wealthy women, whereas such programmes should be provided to all women in more developed countries.

  7. Visual evoked potentials show strong positive association with intracranial pressure in patients with cryptococcal meningitis

    Directory of Open Access Journals (Sweden)

    Marcelo Adriano da Cunha Silva Vieira

    2015-04-01

    Full Text Available Objective : To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP in patients with cryptococcal meningitis. Method The sample included adults diagnosed with cryptococcal meningitis admitted at a reference hospital for infectious diseases. The patients were subjected to F-VEP tests shortly before lumbar puncture. The Pearson’s linear correlation coefficient was calculated and the linear regression analysis was performed. Results : Eighteen individuals were subjected to a total of 69 lumbar punctures preceded by F-VEP tests. At the first lumbar puncture performed in each patient, N2 latency exhibited a strong positive correlation with intracranial pressure (r = 0.83; CI = 0.60 - 0.94; p < 0.0001. The direction of this relationship was maintained in subsequent punctures. Conclusion : The intracranial pressure measured by spinal tap manometry showed strong positive association with the N2 latency F-VEP in patients with cryptococcal meningitis.

  8. Photovoltaic: time for network parity

    International Nuclear Information System (INIS)

    Boulanger, V.

    2013-01-01

    Since 2012 the purchase tariff of photovoltaic power in Germany has been below the price of electricity for households which means that network parity has been reached. New economical schemes combining self-consumption and direct access to the power grid are now possible. (A.C.)

  9. Time reversal and parity tests

    International Nuclear Information System (INIS)

    Terwilliger, K.

    1975-01-01

    A recent review by Henley discusses the present status of Time Reversal and Parity symmetry violations, and comments on the implications for high energy hadron scattering. This note will briefly summarize the situation with particular attention to the sizes of possible effects, relating them to experimental accuracy available or reasonably possible at the ZGS

  10. Parity games and propositional proofs

    Czech Academy of Sciences Publication Activity Database

    Beckmann, A.; Pudlák, Pavel; Thapen, Neil

    2014-01-01

    Roč. 15, č. 2 (2014), s. 17 ISSN 1529-3785 R&D Projects: GA AV ČR IAA100190902 Institutional support: RVO:67985840 Keywords : bounded arithmetic * mean payoff games * parity games Subject RIV: BA - General Mathematics Impact factor: 0.618, year: 2014 http://dl.acm.org/ citation .cfm?doid=2616911.2579822

  11. Parity games and propositional proofs

    Czech Academy of Sciences Publication Activity Database

    Beckmann, A.; Pudlák, Pavel; Thapen, Neil

    2014-01-01

    Roč. 15, č. 2 (2014), s. 17 ISSN 1529-3785 R&D Projects: GA AV ČR IAA100190902 Institutional support: RVO:67985840 Keywords : bounded arithmetic * mean payoff games * parity games Subject RIV: BA - General Mathematics Impact factor: 0.618, year: 2014 http://dl.acm.org/citation.cfm?doid=2616911.2579822

  12. Discovery of Parity Violation

    Indian Academy of Sciences (India)

    The strengths of these interactions, defined by how ... The strong and weak interactions have very short ranges and manifest themselves only .... Nuclear moments are associated with the protons and neutrons, and these are smaller by a factor ...

  13. Permutation parity machines for neural cryptography.

    Science.gov (United States)

    Reyes, Oscar Mauricio; Zimmermann, Karl-Heinz

    2010-06-01

    Recently, synchronization was proved for permutation parity machines, multilayer feed-forward neural networks proposed as a binary variant of the tree parity machines. This ability was already used in the case of tree parity machines to introduce a key-exchange protocol. In this paper, a protocol based on permutation parity machines is proposed and its performance against common attacks (simple, geometric, majority and genetic) is studied.

  14. Permutation parity machines for neural cryptography

    International Nuclear Information System (INIS)

    Reyes, Oscar Mauricio; Zimmermann, Karl-Heinz

    2010-01-01

    Recently, synchronization was proved for permutation parity machines, multilayer feed-forward neural networks proposed as a binary variant of the tree parity machines. This ability was already used in the case of tree parity machines to introduce a key-exchange protocol. In this paper, a protocol based on permutation parity machines is proposed and its performance against common attacks (simple, geometric, majority and genetic) is studied.

  15. Factor analysis shows association between family activity environment and children's health behaviour.

    Science.gov (United States)

    Hendrie, Gilly A; Coveney, John; Cox, David N

    2011-12-01

    To characterise the family activity environment in a questionnaire format, assess the questionnaire's reliability and describe its predictive ability by examining the relationships between the family activity environment and children's health behaviours - physical activity, screen time and fruit and vegetable intake. This paper describes the creation of a tool, based on previously validated scales, adapted from the food domain. Data are from 106 children and their parents (Adelaide, South Australia). Factor analysis was used to characterise factors within the family activity environment. Pearson-Product Moment correlations between the family environment and child outcomes, controlling for demographic variation, were examined. Three factors described the family activity environment - parental activity involvement, opportunity for role modelling and parental support for physical activity - and explained 37.6% of the variance. Controlling for demographic factors, the scale was significantly correlated with children's health behaviour - physical activity (r=0.27), screen time (r=-0.24) and fruit and vegetable intake (r=0.34). The family activity environment questionnaire shows high internal consistency and moderate predictive ability. This study has built on previous research by taking a more comprehensive approach to measuring the family activity environment. This research suggests the family activity environment should be considered in family-based health promotion interventions. © 2011 The Authors. ANZJPH © 2011 Public Health Association of Australia.

  16. Stuttering mostly speeds up solving parity games

    NARCIS (Netherlands)

    Cranen, S.; Keiren, J.J.A.; Willemse, T.A.C.; Bobaru, M.; Havelund, K.; Holzmann, G.J.; Joshi, R.

    2011-01-01

    We study the process theoretic notion of stuttering equivalence in the setting of parity games. We demonstrate that stuttering equivalent vertices have the same winner in the parity game. This means that solving a parity game can be accelerated by minimising the game graph with respect to stuttering

  17. Genome-wide association study identifies novel locus for neuroticism and shows polygenic association with Major Depressive Disorder

    Science.gov (United States)

    de Moor, Marleen H.M.; van den Berg, Stéphanie M.; Verweij, Karin J.H.; Krueger, Robert F.; Luciano, Michelle; Vasquez, Alejandro Arias; Matteson, Lindsay K.; Derringer, Jaime; Esko, Tõnu; Amin, Najaf; Gordon, Scott D.; Hansell, Narelle K.; Hart, Amy B.; Seppälä, Ilkka; Huffman, Jennifer E.; Konte, Bettina; Lahti, Jari; Lee, Minyoung; Miller, Mike; Nutile, Teresa; Tanaka, Toshiko; Teumer, Alexander; Viktorin, Alexander; Wedenoja, Juho; Abecasis, Goncalo R.; Adkins, Daniel E.; Agrawal, Arpana; Allik, Jüri; Appel, Katja; Bigdeli, Timothy B.; Busonero, Fabio; Campbell, Harry; Costa, Paul T.; Smith, George Davey; Davies, Gail; de Wit, Harriet; Ding, Jun; Engelhardt, Barbara E.; Eriksson, Johan G.; Fedko, Iryna O.; Ferrucci, Luigi; Franke, Barbara; Giegling, Ina; Grucza, Richard; Hartmann, Annette M.; Heath, Andrew C.; Heinonen, Kati; Henders, Anjali K.; Homuth, Georg; Hottenga, Jouke-Jan; Janzing, Joost; Jokela, Markus; Karlsson, Robert; Kemp, John P.; Kirkpatrick, Matthew G.; Latvala, Antti; Lehtimäki, Terho; Liewald, David C.; Madden, Pamela A.F.; Magri, Chiara; Magnusson, Patrik K.E.; Marten, Jonathan; Maschio, Andrea; Medland, Sarah E.; Mihailov, Evelin; Milaneschi, Yuri; Montgomery, Grant W.; Nauck, Matthias; Ouwens, Klaasjan G.; Palotie, Aarno; Pettersson, Erik; Polasek, Ozren; Qian, Yong; Pulkki-Råback, Laura; Raitakari, Olli T.; Realo, Anu; Rose, Richard J.; Ruggiero, Daniela; Schmidt, Carsten O.; Slutske, Wendy S.; Sorice, Rossella; Starr, John M.; Pourcain, Beate St; Sutin, Angelina R.; Timpson, Nicholas J.; Trochet, Holly; Vermeulen, Sita; Vuoksimaa, Eero; Widen, Elisabeth; Wouda, Jasper; Wright, Margaret J.; Zgaga, Lina; Scotland, Generation; Porteous, David; Minelli, Alessandra; Palmer, Abraham A.; Rujescu, Dan; Ciullo, Marina; Hayward, Caroline; Rudan, Igor; Metspalu, Andres; Kaprio, Jaakko; Deary, Ian J.; Räikkönen, Katri; Wilson, James F.; Keltikangas-Järvinen, Liisa; Bierut, Laura J.; Hettema, John M.; Grabe, Hans J.; van Duijn, Cornelia M.; Evans, David M.; Schlessinger, David; Pedersen, Nancy L.; Terracciano, Antonio; McGue, Matt; Penninx, Brenda W.J.H.; Martin, Nicholas G.; Boomsma, Dorret I.

    2015-01-01

    shows that neuroticism is influenced by many genetic variants of small effect that are either common or tagged by common variants. These genetic variants also influence MDD. Future studies should confirm the role of the MAGI1 locus for neuroticism, and further investigate the association of MAGI1 and the polygenic association to a range of other psychiatric disorders that are phenotypically correlated with neuroticism. PMID:25993607

  18. Older Adults Show Deficits in Retrieving and Decoding Associative Mediators Generated at Study

    Science.gov (United States)

    Hertzog, Christopher; Fulton, Erika K.; Mandviwala, Lulua; Dunlosky, John

    2013-01-01

    We instructed the use of mediators to encode paired-associate items, and then measured both cued recall of targets and mediators. Older adults (n = 49) and younger adults (n = 57) studied a mixed list of concrete and abstract noun pairs under instructions to either generate a sentence or an image to form a new association between normatively…

  19. Parity violation in electron scattering

    International Nuclear Information System (INIS)

    Lhuillier, D.

    2007-09-01

    The elaboration of the electroweak standard model from the discovery of parity violation to the weak neutral current is described in the first chapter. In the second chapter the author discusses the 2 experimental approaches of the parity violation experiments. In the first approach the weak neutral current can be assumed to be well known and can be used as a probe for the hadronic matter. The second approach consists in measuring the weak neutral current between 2 particles with known internal structure in order to test the predictions of the standard model in the low energy range. The chapters 3 and 4 are an illustration of the first approach through the HAPPEx series of experiments that took place in the Jefferson Laboratory from 1998 to 2005. The HAPPEx experiments aimed at measuring the contribution of strange quarks in the electromagnetic form factors of the nucleon through the violation of parity in the elastic scattering at forward angles. The last chapter is dedicated to the E158 experiment that was performed at the Slac (California) between 2000 and 2003. The weak neutral current was measured between 2 electrons and the high accuracy obtained allowed the physics beyond the standard model to be indirectly constraint up to a few TeV. (A.C.)

  20. Gene-set analysis shows association between FMRP targets and autism spectrum disorder

    NARCIS (Netherlands)

    Jansen, Arija; Dieleman, Gwen C; Smit, August B; Verhage, Matthijs; Verhulst, Frank C; Polderman, Tinca J C; Posthuma, Danielle

    Autism spectrum disorder (ASD) is a heterogeneous group of disorders characterized by problems with social interaction, communication, and repetitive and restricted behavior. Despite its high heritability and the substantial progress made in elucidating genetic associations, the corresponding

  1. The IAT shows no evidence for Kandinsky’s colour-shape associations

    Directory of Open Access Journals (Sweden)

    Alexis eMakin

    2013-09-01

    Full Text Available In the early 20th century, the Bauhaus revolutionised art & design by using simple colours and forms. Wassily Kandinsky was especially interested in the relationship of these two visual attributes and postulated a fundamental correspondence between colour and form: yellow triangle, red square and blue circle. Subsequent empirical studies also used preference judgments to test Kandinsky’s original colour-form combinations, usually yielding inconsistent results. We have set out to test the validity of these postulated associations by using the Implicit Association Test. Participants pressed one of two buttons on each trial. On some trials they classified shapes (e.g. circle or triangle. On interleaved trials they classified colours (e.g. blue or yellow. Response times should theoretically be faster when the button mapping follows Kandinsky’s associations: For example, when the left key is used to report blue or circle and the right is used for yellow and triangle, than when the response mapping is the opposite of this (blue or triangle, yellow or circle. Our findings suggest that there is no implicit association between the original colour-form combinations. Of the three combinations we tested, no response time differences were significantly greater than zero, although there was a marginal effect in one experiment. It can be concluded that our IAT does not support all Kandinsky’s postulated colour-form associations, and these are probably not an aesthetic universal.

  2. The IAT shows no evidence for Kandinsky's color-shape associations.

    Science.gov (United States)

    Makin, Alexis D J; Wuerger, Sophie M

    2013-01-01

    In the early twentieth century, the Bauhaus revolutionized art and design by using simple colors and forms. Wassily Kandinsky was especially interested in the relationship of these two visual attributes and postulated a fundamental correspondence between color and form: yellow triangle, red square and blue circle. Subsequent empirical studies used preference judgments to test Kandinsky's original color-form combinations, usually yielding inconsistent results. We have set out to test the validity of these postulated associations by using the Implicit Association Test. Participants pressed one of two buttons on each trial. On some trials they classified shapes (e.g., circle or triangle). On interleaved trials they classified colors (e.g., blue or yellow). Response times should theoretically be faster when the button mapping follows Kandinsky's associations: For example, when the left key is used to report blue or circle and the right is used for yellow and triangle, than when the response mapping is the opposite of this (blue or triangle, yellow or circle). Our findings suggest that there is no implicit association between the original color-form combinations. Of the three combinations we tested, there was only a marginal effect in one case. It can be concluded that the IAT does not support Kandinsky's postulated color-form associations, and that these are probably not a universal property of the visual system.

  3. Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes.

    Science.gov (United States)

    Luciano, Michelle; Hagenaars, Saskia P; Cox, Simon R; Hill, William David; Davies, Gail; Harris, Sarah E; Deary, Ian J; Evans, David M; Martin, Nicholas G; Wright, Margaret J; Bates, Timothy C

    2017-09-01

    Impairments in reading and in language have negative consequences on life outcomes, but it is not known to what extent genetic effects influence this association. We constructed polygenic scores for difficulties with language and learning to read from genome-wide data in ~6,600 children, adolescents and young adults, and tested their association with health, socioeconomic outcomes and brain structure measures collected in adults (maximal N = 111,749). Polygenic risk of reading difficulties was associated with reduced income, educational attainment, self-rated health and verbal-numerical reasoning (p intelligence) and 0.70 (educational attainment) with reading ability. Mendelian randomization approaches will be important to dissociate any causal and moderating effects of reading and related traits on social outcomes.

  4. Association of breast cancer risk with genetic variants showing differential allelic expression

    DEFF Research Database (Denmark)

    Hamdi, Yosr; Soucy, Penny; Adoue, Véronique

    2016-01-01

    There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with differential allelic expression are functional...

  5. Controlled parity switch of persistent currents in quantum ladders

    Science.gov (United States)

    Filippone, Michele; Bardyn, Charles-Edouard; Giamarchi, Thierry

    2018-05-01

    We investigate the behavior of persistent currents for a fixed number of noninteracting fermions in a periodic quantum ladder threaded by Aharonov-Bohm and transverse magnetic fluxes Φ and χ . We show that the coupling between ladder legs provides a way to effectively change the ground-state fermion-number parity, by varying χ . Specifically, we demonstrate that varying χ by 2 π (one flux quantum) leads to an apparent fermion-number parity switch. We find that persistent currents exhibit a robust 4 π periodicity as a function of χ , despite the fact that χ →χ +2 π leads to modifications of order 1 /N of the energy spectrum, where N is the number of sites in each ladder leg. We show that these parity-switch and 4 π periodicity effects are robust with respect to temperature and disorder, and outline potential physical realizations using cold atomic gases and photonic lattices, for bosonic analogs of the effects.

  6. Macaque homologs of EBV and KSHV show uniquely different associations with simian AIDS-related lymphomas.

    Directory of Open Access Journals (Sweden)

    A Gregory Bruce

    Full Text Available Two gammaherpesviruses, Epstein-Barr virus (EBV (Lymphocryptovirus genus and Kaposi's sarcoma-associated herpesvirus (KSHV (Rhadinovirus genus have been implicated in the etiology of AIDS-associated lymphomas. Homologs of these viruses have been identified in macaques and other non-human primates. In order to assess the association of these viruses with non-human primate disease, archived lymphoma samples were screened for the presence of macaque lymphocryptovirus (LCV homologs of EBV, and macaque rhadinoviruses belonging to the RV1 lineage of KSHV homologs or the more distant RV2 lineage of Old World primate rhadinoviruses. Viral loads were determined by QPCR and infected cells were identified by immunolabeling for different viral proteins. The lymphomas segregated into three groups. The first group (n = 6 was associated with SIV/SHIV infections, contained high levels of LCV (1-25 genomes/cell and expressed the B-cell antigens CD20 or BLA.36. A strong EBNA-2 signal was detected in the nuclei of the neoplastic cells in one of the LCV-high lymphomas, indicative of a type III latency stage. None of the lymphomas in this group stained for the LCV viral capsid antigen (VCA lytic marker. The second group (n = 5 was associated with D-type simian retrovirus-2 (SRV-2 infections, contained high levels of RV2 rhadinovirus (9-790 genomes/cell and expressed the CD3 T-cell marker. The third group (n = 3 was associated with SIV/SHIV infections, contained high levels of RV2 rhadinovirus (2-260 genomes/cell and was negative for both CD20 and CD3. In both the CD3-positive and CD3/CD20-negative lymphomas, the neoplastic cells stained strongly for markers of RV2 lytic replication. None of the lymphomas had detectable levels of retroperitoneal fibromatosis herpesvirus (RFHV, the macaque RV1 homolog of KSHV. Our data suggest etiological roles for both lymphocryptoviruses and RV2 rhadinoviruses in the development of simian AIDS-associated lymphomas and indicate that

  7. Fibrillary glomerulonephritis associated with monoclonal gammopathy of undetermined significance showing lambda-type Bence Jones protein.

    Science.gov (United States)

    Nagao, Tomoaki; Okura, Takafumi; Miyoshi, Ken-Ichi; Watanabe, Sanae; Manabe, Seiko; Kurata, Mie; Irita, Jun; Fukuoka, Tomikazu; Higaki, Jitsuo

    2005-09-01

    A 79-year-old woman was admitted to our hospital because of leg edema due to a nephrotic syndrome. Urinary and serum immunoelectrophoresis showed positive for the lambda type of Bence Jones protein. A bone marrow aspiration test revealed mild plasmacytosis (6.4% of the total cells). These findings confirmed her diagnosis of monoclonal gammopathy of undetermined significance (MGUS). Her renal biopsy specimen revealed mild mesangial cell proliferation and an increase in the mesangial matrix. Immunofluorescence studies showed positive staining for IgG, IgA, C3, and kappa and lambda light chains in the capillary wall and mesangium area. Electron microscopy showed that the electron deposits in the thickened basement membrane were formed by randomly arranged 16- to 18-nm nonbranching fibrils. A Congo red stain for amyloid was negative. These findings corresponded with the diagnosis of fibrillary glomerulonephritis. Therefore, this case showed a rare combination of fibrillary glomerulonephritis and MGUS.

  8. Sirenomelia: a new type, showing VACTERL association with Thomas syndrome and a review of literature.

    Science.gov (United States)

    Lhuaire, Martin; Jestin, Agnès; Boulagnon, Camille; Loock, Mélanie; Doco-Fenzy, Martine; Gaillard, Dominique; Diebold, Marie-Danièle; Avisse, Claude; Labrousse, Marc

    2013-03-01

    Sirenomelia or "mermaid syndrome" is a rare congenital anomaly known since antiquity. This congenital anomaly is defined as a polymalformative syndrome that associates major muscle and skeleton abnormalities (unique lower limbs) with visceral abnormalities (unilateral or bilateral renal agenesis, anomalies of the abdominal vascularisation). This phenotype, typical of sirenomelia syndrome, may be more or less severe. The pathogenic mechanisms of this syndrome are still debated and its etiology remains unknown. We report here a new type of sirenomelia that we observed in a fetus belonging to the collection of the Department of Anatomy of Reims, which led us to perform a comprehensive review of the literature on the subject: this type has never been reported and cannot be classified according to the Stocker and Heifetz classification. Moreover, this case also presents a VACTERL association with Thomas syndrome. Copyright © 2013 Wiley Periodicals, Inc.

  9. Parity proofs of the Kochen–Specker theorem based on 60 complex rays in four dimensions

    International Nuclear Information System (INIS)

    Waegell, Mordecai; Aravind, P K

    2011-01-01

    It is pointed out that the 60 complex rays in four dimensions associated with a system of two qubits yield over 10 9 critical parity proofs of the Kochen–Specker theorem. The geometrical properties of the rays are described, an overview of the parity proofs contained in them is given and examples of some of the proofs are exhibited. (paper)

  10. Is Gender Parity Imminent in the Professoriate? Lessons from One Canadian University

    Science.gov (United States)

    Wilson, Marnie; Gadbois, Shannon; Nichol, Kathleen

    2008-01-01

    This article examined issues and implications associated with gender parity in the professoriate. The findings, based on the results from one Canadian institution's most recent women's committee report, emphasize the importance of monitoring progress toward gender parity by examining potential indicators of gender imbalances such as gender…

  11. The parity-preserving massive QED3: Vanishing β-function and no parity anomaly

    Directory of Open Access Journals (Sweden)

    O.M. Del Cima

    2015-11-01

    Full Text Available The parity-preserving massive QED3 exhibits vanishing gauge coupling β-function and is parity and infrared anomaly free at all orders in perturbation theory. Parity is not an anomalous symmetry, even for the parity-preserving massive QED3, in spite of some claims about the possibility of a perturbative parity breakdown, called parity anomaly. The proof is done by using the algebraic renormalization method, which is independent of any regularization scheme, based on general theorems of perturbative quantum field theory.

  12. Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

    International Nuclear Information System (INIS)

    Pitt, Jason; Roth, William; Lacor, Pascale; Smith, Amos B.; Blankenship, Matthew; Velasco, Pauline; De Felice, Fernanda; Breslin, Paul; Klein, William L.

    2009-01-01

    It now appears likely that soluble oligomers of amyloid-β 1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer's disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (referred to as ADDLs) may have potential for AD therapeutics. Phenolic compounds are of particular interest for their ability to disrupt Aβ oligomerization and reduce pathogenicity. This study has focused on oleocanthal (OC), a naturally-occurring phenolic compound found in extra-virgin olive oil. OC increased the immunoreactivity of soluble Aβ species, when assayed with both sequence- and conformation-specific Aβ antibodies, indicating changes in oligomer structure. Analysis of oligomers in the presence of OC showed an upward shift in MW and a ladder-like distribution of SDS-stable ADDL subspecies. In comparison with control ADDLs, oligomers formed in the presence of OC (Aβ-OC) showed equivalent colocalization at synapses but exhibited greater immunofluorescence as a result of increased antibody recognition. The enhanced signal at synapses was not due to increased synaptic binding, as direct detection of fluorescently-labeled ADDLs showed an overall reduction in ADDL signal in the presence of OC. Decreased binding to synapses was accompanied by significantly less synaptic deterioration assayed by drebrin loss. Additionally, treatment with OC improved antibody clearance of ADDLs. These results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics.

  13. Resistin polymorphisms show associations with obesity, but not with bone parameters in men

    DEFF Research Database (Denmark)

    Beckers, Sigri; Zegers, Doreen; Van Camp, Jasmijn K

    2013-01-01

    Resistin is an obesity-related adipokine which has also been implicated in bone metabolism. Therefore, we designed a study to investigate the possible role of resistin gene variation in both obesity and bone mineral density. We included 1,155 individuals from the Odense Androgen Study (663 young...... subjects and 492 older subjects), a population-based, prospective, observational study on the inter-relationship between endocrine status, body composition, muscle function, and bone metabolism in men, in an association study with resistin (RETN) polymorphisms. Three RETN variants (rs1862513, rs3745367....... Research into its possible functional effect might also be required. A role for RETN variants in determining bone mineral density seems unlikely from our results....

  14. Κ-meson decays and parity violation

    International Nuclear Information System (INIS)

    Dalitz, R.H.

    1989-01-01

    Between 1948 and 1954 many Κ-meson decay modes were observed, including the tau, pion and xi positives, in emulsion experiments all with masses around 500 MeV. An attempt was made to rationalize the various names for the new particles being discovered. A period of experimental consolidation followed. An attempt was then made to determine the spin parity of the three-pion system from tau plus decay using matrix calculations. New stripped emulsion techniques now permitted a secondary-particle track to be followed to its endpoint. Stacked emulsions were flown in balloons to study Κ mesons and hyperons using cosmic radiation. Later similar work used the new particle accelerators, the Cosmotron and the Bevatron as sources. The author showed that the tau plus and theta plus were competing decay modes of the same Κ + meson, but this meant that parity conservation was violated. Later theoreticians T D Lee and C N Yang provided evidence for this surprising idea from their work on semileptonic weak interactions. (UK)

  15. Maternal Parity and Blood Oxidative Stress in Mother and Neonate

    OpenAIRE

    Golalizadeh; Shobeiri; Ranjbar; Nazari

    2016-01-01

    Background Parturition has been associated with free radicals, itself linked with poor pregnancy outcome. Objectives This study aimed to investigate the relationship between oxidative stress biomarkers levels of maternal and cord blood samples at the second stage of labor with the maternal parity number. Materials and Methods In this analytical cross-sectional study, subjects were ...

  16. Analysis of parity violating nuclear effects at low energy

    Energy Technology Data Exchange (ETDEWEB)

    Desplanques, B; Missimer, J [Carnegie-Mellon Univ., Pittsburgh, Pa. (USA). Dept. of Physics

    1978-05-15

    The authors present an analysis of parity-violating nuclear effects at low energy which attempts to circumvent the uncertainties due to the weak and strong nucleon-nucleon interactions at short distances. Extending Danilov's parametrization of the parity-violating nucleon-nucleon scattering amplitude, they introduce six parameters: one for the long-range contribution due to the pion exchange and five for the shorter-range contributions. This choice gives an accurate representation of parity-violating effects in the nucleon-nucleon system up to a lab energy of 75 MeV. For calculations in nuclei, an effective two-body potential is derived in terms of the parameters. The analysis of presently measured effects shows that they are consistent, and, in particular, that the circular polarization of photons in n + p ..-->.. d + ..gamma.. is not incompatible with the other measurements. It does not imply a dominant isotensor component.

  17. Spin and parity measurement of the Λ(1405) baryon

    Science.gov (United States)

    Moriya, K.; Schumacher, R. A.; Aghasyan, M.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Bellis, M.; Biselli, A. S.; Bono, J.; Boiarinov, S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Cole, P. L.; Collins, P.; Contalbrigo, M.; Cortes, O.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Dey, B.; Djalali, C.; Dugger, M.; Dupré, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fleming, J. A.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Guidal, M.; Griffioen, K. A.; Hafidi, K.; Hakobyan, H.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Keller, D.; Khandaker, M.; Kim, W.; Koirala, S.; Kubarovsky, V.; Kuleshov, S. V.; Lenisa, P.; Lu, H. Y.; MacGregor, I. J. D.; Markov, N.; McCracken, M.; McKinnon, B.; Mestayer, M. D.; Meyer, C. A.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Moutarde, H.; Munevar, E.; Nadel-Turonski, P.; Niccolai, S.; Niculescu, I.; Osipenko, M.; Pappalardo, L. L.; Pasyuk, E.; Peng, P.; Phillips, J. J.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Puckett, A. J. R.; Raue, B. A.; Rimal, D.; Ripani, M.; Ritchie, B. G.; Rizzo, A.; Rosner, G.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Seder, E.; Senderovich, I.; Smith, E. S.; Sokhan, D.; Smith, G. D.; Stepanyan, S.; Strauch, S.; Tang, W.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Weinstein, L. B.; Williams, M.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Ziegler, V.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

    2014-02-01

    A determination of the spin and parity of the Λ(1405) is presented using photoproduction data from the CLAS detector at Jefferson Lab. The reaction γ+p→K++Λ(1405) is analyzed in the decay channel Λ(1405)→Σ ++π-, where the decay distribution to Σ+π- and the variation of the Σ+ polarization with respect to the Λ(1405) polarization direction determines the parity. The Λ(1405) is produced, in the energy range 2.55shows that the decays are in S wave, with the Σ+ polarized such that the Λ(1405) has spin-parity JP=1/2-, as expected by most theories.

  18. Non-planar ABJ theory and parity

    International Nuclear Information System (INIS)

    Caputa, Pawel; Kristjansen, Charlotte; Zoubos, Konstantinos

    2009-01-01

    While the ABJ Chern-Simons-matter theory and its string theory dual manifestly lack parity invariance, no sign of parity violation has so far been observed on the weak coupling spin chain side. In particular, the planar two-loop dilatation generator of ABJ theory is parity invariant. In this Letter we derive the non-planar part of the two-loop dilatation generator of ABJ theory in its SU(2)xSU(2) sub-sector. Applying the dilatation generator to short operators, we explicitly demonstrate that, for operators carrying excitations on both spin chains, the non-planar part breaks parity invariance. For operators with only one type of excitation, however, parity remains conserved at the non-planar level. We furthermore observe that, as for ABJM theory, the degeneracy between planar parity pairs is lifted when non-planar corrections are taken into account.

  19. Non-planar ABJ Theory and Parity

    DEFF Research Database (Denmark)

    Caputa, Pawel; Kristjansen, Charlotte; Zoubos, Konstantinos

    2009-01-01

    we derive the non-planar part of the two-loop dilatation generator of ABJ theory in its SU(2)xSU(2) sub-sector. Applying the dilatation generator to short operators, we explicitly demonstrate that, for operators carrying excitations on both spin chains, the non-planar part breaks parity invariance......While the ABJ Chern-Simons-matter theory and its string theory dual manifestly lack parity invariance, no sign of parity violation has so far been observed on the weak coupling spin chain side. In particular, the planar two-loop dilatation generator of ABJ theory is parity invariant. In this letter....... For operators with only one type of excitation, however, parity remains conserved at the non-planar level. We furthermore observe that, as for ABJM theory, the degeneracy between planar parity pairs is lifted when non-planar corrections are taken into account....

  20. Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and clavulanic acid biosynthesis.

    Science.gov (United States)

    Ramirez-Malule, Howard; Junne, Stefan; Nicolás Cruz-Bournazou, Mariano; Neubauer, Peter; Ríos-Estepa, Rigoberto

    2018-05-01

    Clavulanic acid (CA) is produced by Streptomyces clavuligerus (S. clavuligerus) as a secondary metabolite. Knowledge about the carbon flux distribution along the various routes that supply CA precursors would certainly provide insights about metabolic performance. In order to evaluate metabolic patterns and the possible accumulation of tricarboxylic acid (TCA) cycle intermediates during CA biosynthesis, batch and subsequent continuous cultures with steadily declining feed rates were performed with glycerol as the main substrate. The data were used to in silico explore the metabolic capabilities and the accumulation of metabolic intermediates in S. clavuligerus. While clavulanic acid accumulated at glycerol excess, it steadily decreased at declining dilution rates; CA synthesis stopped when glycerol became the limiting substrate. A strong association of succinate, oxaloacetate, malate, and acetate accumulation with CA production in S. clavuligerus was observed, and flux balance analysis (FBA) was used to describe the carbon flux distribution in the network. This combined experimental and numerical approach also identified bottlenecks during the synthesis of CA in a batch and subsequent continuous cultivation and demonstrated the importance of this type of methodologies for a more advanced understanding of metabolism; this potentially derives valuable insights for future successful metabolic engineering studies in S. clavuligerus.

  1. Local Strategy Improvement for Parity Game Solving

    OpenAIRE

    Friedmann, Oliver; Lange, Martin

    2010-01-01

    The problem of solving a parity game is at the core of many problems in model checking, satisfiability checking and program synthesis. Some of the best algorithms for solving parity game are strategy improvement algorithms. These are global in nature since they require the entire parity game to be present at the beginning. This is a distinct disadvantage because in many applications one only needs to know which winning region a particular node belongs to, and a witnessing winning strategy may...

  2. Parity-non-conserving nuclear forces

    International Nuclear Information System (INIS)

    Desplanques, B.

    1979-01-01

    Theoretical and phenomenological approaches to parity-non-conserving nuclear forces are reviewed. Recent developments in the calculation of weak meson-nucleon coupling constants, whose knowledge is necessary to determine theoretically the parity-non-conserving nucleon-nucleon potential, are described. The consistency of different measurements of parity-non-conserving effects is discussed and the information they provide is compared to theoretical predictions

  3. Spontaneous parity violation and minimal Higgs models

    International Nuclear Information System (INIS)

    Chavez, H.; Martins Simoes, J.A.

    2007-01-01

    In this paper we present a model for the spontaneous breaking of parity with two Higgs doublets and two neutral Higgs singlets which are even and odd under D-parity. The condition υ R >>υ L can be satisfied without introducing bidoublets, and it is induced by the breaking of D-parity through the vacuum expectation value of the odd Higgs singlet. Examples of left-right symmetric and mirror fermions models in grand unified theories are presented. (orig.)

  4. AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging.

    Science.gov (United States)

    Ordoñez-Gutierrez, Lara; Fernandez-Perez, Ivan; Herrera, Jose Luis; Anton, Marta; Benito-Cuesta, Irene; Wandosell, Francisco

    2016-09-06

    Cerebellar pathology has been related to presenilin 1 mutations in certain pedigrees of familial Alzheimer's disease. However, cerebellum tissue has not been intensively analyzed in transgenic models of mutant presenilins. Furthermore, the effect of the sex of the mice was not systematically analyzed, despite the fact that important gender differences in the evolution of the disease in the human population have been described. We analyzed whether the progression of amyloidosis in a double transgenic mouse, AβPP/PS1, is susceptible to aging and differentially affects males and females. The accumulation of amyloid in the cerebellum differentially affects males and females of the AβPP/PS1 transgenic line, which was found to be ten-fold higher in 15-month-old females. Amyloid-β accumulation was more evident in the molecular layer of the cerebellum, but glia reaction was only observed in the granular layer of the older mice. The sex divergence was also observed in other neuronal, survival, and autophagic markers. The cerebellum plays an important role in the evolution of the pathology in this transgenic mouse model. Sex differences could be crucial for a complete understanding of this disease. We propose that the human population could be studied in this way. Sex-specific treatment strategies in human populations could show a differential response to the therapeutic approach.

  5. Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells.

    Science.gov (United States)

    Honda, Yumi; Tanigawa, Hiroki; Harada, Miho; Fukushima, Satoshi; Masuguchi, Shinichi; Ishihara, Tsuyoshi; Ihn, Hironobu; Iyama, Ken-ichi

    2013-05-01

    Herein, we report a 63-year-old man presenting with hidradenocarcinoma showing prominent mucinous and squamous differentiation on his back. The tumor was dermal-based, solid and cystic. Tumor cells with squamous differentiation and with keratin pearl formation were identified predominantly in the superficial dermis, and mucinous cells were identified principally in the cystic lesion in the deep dermis. Interestingly, the additional feature of pagetoid cells was identified in the overlying epidermis. Both the mucinous cells in hidradenocarcinoma and pagetoid cells had intracytoplasmic mucin; however, they had different histopathologic findings and immunophenotypes. Mucinous cells in hidradenocarcinoma had small nuclei and abundant intracytoplasmic mucin presenting goblet cells with low rate of positive immunostaining for p53 and Ki67. In contrast, pagetoid cells had larger nuclei with less intracytoplasmic mucin. Both p53- and Ki67-positive cells were increased in pagetoid cells. Additionally, mucinous cells in hidradenocarcinoma were MUC1(+)/MUC2(-)/MUC5AC(+)/MUC6(+), but pagetoid cells were MUC1(+; focal)/MUC2(-)/MUC5AC(-)/MUC6(+; focal). The derivation of pagetoid cells is unclear; however, the localized small region of pagetoid cells over the hidradenocarcinoma in the present case may suggest a common histogenesis of these two malignant neoplasms. Copyright © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

  6. Association of pre-pregnancy body mass index, pregnancy-related weight changes, and parity with the risk of developing degenerative musculoskeletal conditions

    DEFF Research Database (Denmark)

    Bliddal, Mette; Pottegård, Anton; Kirkegaard, Helene

    2016-01-01

    to normal-weight first time mothers, the highest risk was seen in obese women with >2 childbirths (HR 1.61 [95% confidence interval 1.41-1.83]). Gestational weight gain of 10-15 kg was associated with the lowest risk of MSCs. Compared to women with no change in weight from pre-conception to weight 6 months...

  7. Quaternionic formulation of the exact parity model

    Energy Technology Data Exchange (ETDEWEB)

    Brumby, S.P.; Foot, R.; Volkas, R.R.

    1996-02-28

    The exact parity model (EPM) is a simple extension of the standard model which reinstates parity invariance as an unbroken symmetry of nature. The mirror matter sector of the model can interact with ordinary matter through gauge boson mixing, Higgs boson mixing and, if neutrinos are massive, through neutrino mixing. The last effect has experimental support through the observed solar and atmospheric neutrino anomalies. In the paper it is shown that the exact parity model can be formulated in a quaternionic framework. This suggests that the idea of mirror matter and exact parity may have profound implications for the mathematical formulation of quantum theory. 13 refs.

  8. Quaternionic formulation of the exact parity model

    International Nuclear Information System (INIS)

    Brumby, S.P.; Foot, R.; Volkas, R.R.

    1996-01-01

    The exact parity model (EPM) is a simple extension of the standard model which reinstates parity invariance as an unbroken symmetry of nature. The mirror matter sector of the model can interact with ordinary matter through gauge boson mixing, Higgs boson mixing and, if neutrinos are massive, through neutrino mixing. The last effect has experimental support through the observed solar and atmospheric neutrino anomalies. In the paper it is shown that the exact parity model can be formulated in a quaternionic framework. This suggests that the idea of mirror matter and exact parity may have profound implications for the mathematical formulation of quantum theory. 13 refs

  9. Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity.

    Science.gov (United States)

    Elbing, Karin; Rubenstein, Eric M; McCartney, Rhonda R; Schmidt, Martin C

    2006-09-08

    The Snf1 kinase and its mammalian orthologue, the AMP-activated protein kinase (AMPK), function as heterotrimers composed of a catalytic alpha-subunit and two non-catalytic subunits, beta and gamma. The beta-subunit is thought to hold the complex together and control subcellular localization whereas the gamma-subunit plays a regulatory role by binding to and blocking the function of an auto-inhibitory domain (AID) present in the alpha-subunit. In addition, catalytic activity requires phosphorylation by a distinct upstream kinase. In yeast, any one of three Snf1-activating kinases, Sak1, Tos3, or Elm1, can fulfill this role. We have previously shown that Sak1 is the only Snf1-activating kinase that forms a stable complex with Snf1. Here we show that the formation of the Sak1.Snf1 complex requires the beta- and gamma-subunits in vivo. However, formation of the Sak1.Snf1 complex is not necessary for glucose-regulated phosphorylation of the Snf1 activation loop. Snf1 kinase purified from cells lacking the beta-subunits do not contain any gamma-subunit, indicating that the Snf1 kinase does not form a stable alphagamma dimer in vivo. In vitro kinase assays using purified full-length and truncated Snf1 proteins demonstrate that the kinase domain, which lacks the AID, is significantly more active than the full-length Snf1 protein. Addition of purified beta- and gamma-subunits could stimulate the kinase activity of the full-length alpha-subunit but only when all three subunits were present, suggesting an interdependence of all three subunits for assembly of a functional complex.

  10. Nuclear parity violation in effective field theory

    International Nuclear Information System (INIS)

    Zhu Shilin; Maekawa, C.M.; Holstein, B.R.; Ramsey-Musolf, M.J.; Kolck, U. van

    2005-01-01

    We reformulate the analysis of nuclear parity violation (PV) within the framework of effective field theory (EFT). To O(Q), the PV nucleon-nucleon (NN) interaction depends on five a priori unknown constants that parameterize the leading-order, short-range four-nucleon operators. When pions are included as explicit degrees of freedom, the potential contains additional medium- and long-range components parameterized by PV πNN coupling. We derive the form of the corresponding one- and two-pion-exchange potentials. We apply these considerations to a set of existing and prospective PV few-body measurements that may be used to determine the five independent low-energy constants relevant to the pionless EFT and the additional constants associated with dynamical pions. We also discuss the relationship between the conventional meson-exchange framework and the EFT formulation, and argue that the latter provides a more general and systematic basis for analyzing nuclear PV

  11. The Fixpoint-Iteration Algorithm for Parity Games

    Directory of Open Access Journals (Sweden)

    Florian Bruse

    2014-08-01

    Full Text Available It is known that the model checking problem for the modal mu-calculus reduces to the problem of solving a parity game and vice-versa. The latter is realised by the Walukiewicz formulas which are satisfied by a node in a parity game iff player 0 wins the game from this node. Thus, they define her winning region, and any model checking algorithm for the modal mu-calculus, suitably specialised to the Walukiewicz formulas, yields an algorithm for solving parity games. In this paper we study the effect of employing the most straight-forward mu-calculus model checking algorithm: fixpoint iteration. This is also one of the few algorithms, if not the only one, that were not originally devised for parity game solving already. While an empirical study quickly shows that this does not yield an algorithm that works well in practice, it is interesting from a theoretical point for two reasons: first, it is exponential on virtually all families of games that were designed as lower bounds for very particular algorithms suggesting that fixpoint iteration is connected to all those. Second, fixpoint iteration does not compute positional winning strategies. Note that the Walukiewicz formulas only define winning regions; some additional work is needed in order to make this algorithm compute winning strategies. We show that these are particular exponential-space strategies which we call eventually-positional, and we show how positional ones can be extracted from them.

  12. In-State and Interstate Associations Between Gun Shows and Firearm Deaths and Injuries: A Quasi-experimental Study.

    Science.gov (United States)

    Matthay, Ellicott C; Galin, Jessica; Rudolph, Kara E; Farkas, Kriszta; Wintemute, Garen J; Ahern, Jennifer

    2017-12-19

    Gun shows are an important source of firearms, but no adequately powered studies have examined whether they are associated with increases in firearm injuries. To determine whether gun shows are associated with short-term increases in local firearm injuries and whether this association differs by the state in which the gun show is held. Quasi-experimental. California. Persons in California within driving distance of gun shows. Gun shows in California and Nevada between 2005 and 2013 (n = 915 shows) and rates of firearm-related deaths, emergency department visits, and inpatient hospitalizations in California. Compared with the 2 weeks before, postshow firearm injury rates remained stable in regions near California gun shows but increased from 0.67 injuries (95% CI, 0.55 to 0.80 injuries) to 1.14 injuries (CI, 0.97 to 1.30 injuries) per 100 000 persons in regions near Nevada shows. After adjustment for seasonality and clustering, California shows were not associated with increases in local firearm injuries (rate ratio [RR], 0.99 [CI, 0.97 to 1.02]) but Nevada shows were associated with increased injuries in California (RR, 1.69 [CI, 1.16 to 2.45]). The pre-post difference was significantly higher for Nevada shows than California shows (ratio of RRs, 1.70 [CI, 1.17 to 2.47]). The Nevada association was driven by significant increases in firearm injuries from interpersonal violence (RR, 2.23 [CI, 1.01 to 4.89]) but corresponded to a small increase in absolute numbers. Nonfirearm injuries served as a negative control and were not associated with California or Nevada gun shows. Results were robust to sensitivity analyses. Firearm injuries were examined only in California, and gun show occurrence was not randomized. Gun shows in Nevada, but not California, were associated with local, short-term increases in firearm injuries in California. Differing associations for California versus Nevada gun shows may be due to California's stricter firearm regulations. National

  13. A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer

    Directory of Open Access Journals (Sweden)

    Christina Marie Gutierrez

    2015-11-01

    Full Text Available Background/Aims: Early parity reduces breast cancer risk, whereas, late parity and nulliparity increase breast cancer risk. Despite substantial efforts to understand the protective effects of early parity, the precise molecular circuitry responsible for these changes is not yet fully defined. Methods: Here, we have conducted the first study assessing protein expression profiles in normal breast tissue of healthy early parous, late parous, and nulliparous women. Breast tissue biopsies were obtained from 132 healthy parous and nulliparous volunteers. These samples were subjected to global protein expression profiling and immunohistochemistry. GeneSpring and MetaCore bioinformatics analysis software were used to identify protein expression profiles associated with early parity (low risk versus late/nulliparity (high risk. Results: Early parity reduces expression of key proteins involved in mitogenic signaling pathways in breast tissue through down regulation of EGFR1/3, ESR1, AKT1, ATF, Fos, and SRC. Early parity is also characterized by greater genomic stability and reduced tissue inflammation based on differential expression of aurora kinases, p53, RAD52, BRCA1, MAPKAPK-2, ATF-1, ICAM1, and NF-kappaB compared to late and nulli parity. Conclusions: Early parity reduces basal cell proliferation in breast tissue, which translates to enhanced genomic stability, reduced cellular stress/inflammation, and thus reduced breast cancer risk.

  14. Generating and Solving Symbolic Parity Games

    NARCIS (Netherlands)

    Kant, Gijs; van de Pol, Jan Cornelis

    We present a new tool for verification of modal mu-calculus formulae for process specifications, based on symbolic parity games. It enhances an existing method, that first encodes the problem to a Parameterised Boolean Equation System (PBES) and then instantiates the PBES to a parity game. We

  15. Parity-Time Symmetric Photonics

    KAUST Repository

    Zhao, Han

    2018-01-17

    The establishment of non-Hermitian quantum mechanics (such as parity-time (PT) symmetry) stimulates a paradigmatic shift for studying symmetries of complex potentials. Owing to the convenient manipulation of optical gain and loss in analogy to the complex quantum potentials, photonics provides an ideal platform for visualization of many conceptually striking predictions from the non-Hermitian quantum theory. A rapidly developing field has emerged, namely, PT symmetric photonics, demonstrating intriguing optical phenomena including eigenstate coalescence and spontaneous PT symmetry breaking. The advance of quantum physics, as the feedback, provides photonics with brand-new paradigms to explore the entire complex permittivity plane for novel optical functionalities. Here, we review recent exciting breakthroughs in PT symmetric photonics while systematically presenting their underlying principles guided by non-Hermitian symmetries. The potential device applications for optical communication and computing, bio-chemical sensing, and healthcare are also discussed.

  16. Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing.

    Science.gov (United States)

    Nashiro, Kaoru; Sakaki, Michiko; Braskie, Meredith N; Mather, Mara

    2017-06-01

    Correlations in activity across disparate brain regions during rest reveal functional networks in the brain. Although previous studies largely agree that there is an age-related decline in the "default mode network," how age affects other resting-state networks, such as emotion-related networks, is still controversial. Here we used a dual-regression approach to investigate age-related alterations in resting-state networks. The results revealed age-related disruptions in functional connectivity in all 5 identified cognitive networks, namely the default mode network, cognitive-auditory, cognitive-speech (or speech-related somatosensory), and right and left frontoparietal networks, whereas such age effects were not observed in the 3 identified emotion networks. In addition, we observed age-related decline in functional connectivity in 3 visual and 3 motor/visuospatial networks. Older adults showed greater functional connectivity in regions outside 4 out of the 5 identified cognitive networks, consistent with the dedifferentiation effect previously observed in task-based functional magnetic resonance imaging studies. Both reduced within-network connectivity and increased out-of-network connectivity were correlated with poor cognitive performance, providing potential biomarkers for cognitive aging. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Analysing the Effect on CMB in a Parity and Charge Parity Violating Varying Alpha Theory

    Energy Technology Data Exchange (ETDEWEB)

    Maity, Debaprasad; /NCTS, Taipei /Taiwan, Natl. Taiwan U.; Chen, Pisin; /NCTS, Taipei /Taiwan, Natl. Taiwan U. /KIPAC, Menlo Park /SLAC

    2012-09-14

    In this paper we study in detail the effect of our recently proposed model of parity and charge-parity (PCP) violating varying alpha on the Cosmic Microwave Background (CMB) photon passing through the intra galaxy-cluster medium (ICM). The ICM is well known to be composed of magnetized plasma. According to our model, the polarization and intensity of the CMB would be affected when traversing through the ICM due to non-trivial scalar photon interactions. We have calculated the evolution of such polarization and intensity collectively, known as the stokes parameters of the CMB photon during its journey through the ICM and tested our results against the Sunyaev-Zel'dovich (SZ) measurement on Coma galaxy cluster. Our model contains a PCP violating parameter, {beta}, and a scale of alpha variation {omega}. Using the derived constrained on the photon-to-scalar conversion probability, {bar P}{sub {gamma}{yields}{phi}}, for Coma cluster in ref.[34] we found a contour plot in the ({omega},{beta}) parameter plane. The {beta} = 0 line in this parameter space corresponds to well-studied Maxwell-dilaton type models which has lower bound on {omega} {approx}> 6.4 x 10{sup 9} GeV. In general, as the absolute value of {beta} increases, lower bound on {omega} also increases. Our model in general predicts the modification of the CMB polarization with a non-trivial dependence on the parity violating coupling parameter {beta}. However, it is unconstrained in this particular study. We show that this effect can in principle be detected in the future measurements on CMB polarization such that {beta} can also be constrained.

  18. R-parity violation at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Dercks, Daniel [Universitaet Bonn, Physikalisches Institut, Bethe Center for Theoretical Physics, Bonn (Germany); Universitaet Hamburg, II. Institut fuer Theoretische Physik, Hamburg (Germany); Dreiner, Herbi; Krauss, Manuel E.; Opferkuch, Toby; Reinert, Annika [Universitaet Bonn, Physikalisches Institut, Bethe Center for Theoretical Physics, Bonn (Germany)

    2017-12-15

    We investigate the phenomenology of the MSSM extended by a single R-parity-violating coupling at the unification scale. For all R-parity-violating couplings, we discuss the evolution of the particle spectra through the renormalization group equations and the nature of the lightest supersymmetric particle (LSP) within the CMSSM, as an example of a specific complete supersymmetric model. We use the nature of the LSP to classify the possible signatures. For each possible scenario we present in detail the current LHC bounds on the supersymmetric particle masses, typically obtained using simplified models. From this we determine the present coverage of R-parity-violating models at the LHC. We find several gaps, in particular for a stau-LSP, which is easily obtained in R-parity-violating models. Using the program CheckMATE we recast existing LHC searches to set limits on the parameters of all R-parity-violating CMSSMs. We find that virtually all of them are either more strongly constrained or similarly constrained in comparison to the R-parity-conserving CMSSM, including the anti U anti D anti D models. For each R-parity-violating CMSSM we then give the explicit lower mass bounds on all relevant supersymmetric particles. (orig.)

  19. Models of dynamical R-parity violation

    Energy Technology Data Exchange (ETDEWEB)

    Csáki, Csaba; Kuflik, Eric [Department of Physics, LEPP, Cornell University, Ithaca, NY 14853 (United States); Slone, Oren; Volansky, Tomer [Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978 (Israel)

    2015-06-08

    The presence of R-parity violating interactions may relieve the tension between existing LHC constraints and natural supersymmetry. In this paper we lay down the theoretical framework and explore models of dynamical R-parity violation in which the breaking of R-parity is communicated to the visible sector by heavy messenger fields. We find that R-parity violation is often dominated by non-holomorphic operators that have so far been largely ignored, and might require a modification of the existing searches at the LHC. The dynamical origin implies that the effects of such operators are suppressed by the ratio of either the light fermion masses or the supersymmetry breaking scale to the mediation scale, thereby providing a natural explanation for the smallness of R-parity violation. We consider various scenarios, classified by whether R-parity violation, flavor breaking and/or supersymmetry breaking are mediated by the same messenger fields. The most compact case, corresponding to a deformation of the so called flavor mediation scenario, allows for the mediation of supersymmetry breaking, R-parity breaking, and flavor symmetry breaking in a unified manner.

  20. The Effect of Age, Parity and Body Mass Index on the Efficacy, Safety, Placement and User Satisfaction Associated With Two Low-Dose Levonorgestrel Intrauterine Contraceptive Systems: Subgroup Analyses of Data From a Phase III Trial.

    Directory of Open Access Journals (Sweden)

    Kristina Gemzell-Danielsson

    Full Text Available Two low-dose levonorgestrel intrauterine contraceptive systems (LNG-IUSs; total content 13.5 mg [average approx. 8 μg/24 hours over the first year; LNG-IUS 8] and total content 19.5 mg [average approx. 13 μg/24 hours over the first year; LNG-IUS 13] have previously been shown to be highly effective (3-year Pearl Indices: 0.33 and 0.31, respectively, safe and well tolerated. The present subgroup analyses evaluated whether or not outcomes were affected by parity, age (18-25 vs 26-35 years, or body mass index (BMI, <30 vs ≥30 kg/m2.Nulliparous and parous women aged 18‒35 years with regular menstrual cycles (21‒35 days requesting contraception were randomized to 3 years of LNG-IUS 8 or LNG-IUS 13 use.In the LNG-IUS 8 and LNG-IUS 13 groups, 1432 and 1452 women, respectively, had a placement attempted and were included in the full analysis set; 39.2%, 39.2% and 17.1% were 18-25 years old, nulliparous and had a BMI ≥30 kg/m2, respectively. Both systems were similarly effective regardless of age, parity or BMI; the subgroup Pearl Indices had widely overlapping 95% confidence intervals. Placement of LNG-IUS 8 and LNG-IUS 13 was easier (p < 0.0001 and less painful (p < 0.0001 in women who had delivered vaginally than in women who had not. The complete/partial expulsion rate was 2.2-4.2% across all age and parity subgroups and higher in parous than in nulliparous women (p = 0.004. The incidence of pelvic inflammatory disease was 0.1-0.6% across all age and parity subgroups: nulliparous and younger women were not at higher risk than parous and older women, respectively. The ectopic pregnancy rate was 0.3-0.4% across all age and parity subgroups. Across all age and parity subgroups, the 3-year completion rate was 50.9-61.3% for LNG-IUS 8 and 57.9-61.1% for LNG-IUS 13, and was higher (p = 0.0001 among older than younger women in the LNG-IUS 8 group only.LNG-IUS 8 and LNG-IUS 13 were highly effective, safe and well tolerated regardless of age or

  1. Watching reality television beauty shows is associated with tanning lamp use and outdoor tanning among college students.

    Science.gov (United States)

    Fogel, Joshua; Krausz, Faye

    2013-05-01

    Ultraviolet radiation exposure through natural sunlight or tanning lamps is a risk factor for skin cancer. As the media can influence behavior, we studied whether watching reality television (TV) beauty shows is associated with tanning lamp use or outdoor tanning. College students (n = 576) were surveyed on their reality TV beauty show watching, their use of tanning lamps, and outdoor tanning behavior. We asked media attitude questions about connectivity with reality TV shows and Internet use of Facebook to discuss reality TV shows. Those who did versus did not watch reality TV beauty shows used tanning lamps (12.9% vs 3.7%, P < .001) and tanned outdoors (43.3% vs 28.7%, P < .001) at significantly greater percentages. Significant predictors of tanning lamp use included watching reality TV beauty shows (odds ratio [OR] 2.58, 95% confidence interval [CI] 1.11-6.00), increasing age (OR 1.17, 95% CI 1.04-1.32), and female sex (OR 10.16, 95% CI 3.29-31.41). Significant predictors of outdoor tanning included watching reality TV beauty shows (OR 2.11, 95% CI 1.33-3.34). The specific names of the reality TV beauty shows watched were not obtained and therefore we cannot determine if particular shows were more or less associated with this behavior. Watching reality TV beauty shows is associated with both tanning lamp use and outdoor tanning. Dermatologists should consider discussing the potential harmful aspects of tanning beds and outdoor tanning, especially with their patients who watch reality TV beauty shows. Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  2. A naturally narrow positive-parity Θ+

    International Nuclear Information System (INIS)

    Carlson, Carl E.; Carone, Christopher D.; Kwee, Herry J.; Nazaryan, Vahagn

    2004-01-01

    We present a consistent color-flavor-spin-orbital wave function for a positive-parity Θ + that naturally explains the observed narrowness of the state. The wave function is totally symmetric in its flavor-spin part and totally antisymmetric in its color-orbital part. If flavor-spin interactions dominate, this wave function renders the positive-parity Θ + lighter than its negative-parity counterpart. We consider decays of the Θ + and compute the overlap of this state with the kinematically allowed final states. Our results are numerically small. We note that dynamical correlations between quarks are not necessary to obtain narrow pentaquark widths

  3. Positronic complexes with unnatural parity

    International Nuclear Information System (INIS)

    Bromley, M. W. J.; Mitroy, J.; Varga, K.

    2007-01-01

    The structure of the unnatural parity states of PsH, LiPs, NaPs, and KPs are investigated with the configuration interaction and stochastic variational methods. The binding energies (in hartree) are found to be 8.17x10 -4 , 4.42x10 -4 , 15.14x10 -4 , and 21.80x10 -4 , respectively. These states are constructed by first coupling the two electrons into a configuration which is predominantly 3 P e , and then adding a p-wave positron. All the active particles are in states in which the relative angular momentum between any pair of particles is at least L=1. The LiPs state is Borromean since there are no three-body bound subsystems (of the correct symmetry) of the (Li + , e - , e - , e + ) particles that make up the system. The dominant decay mode of these states will be radiative decay into a configuration that autoionizes or undergoes positron annihilation

  4. Purchasing Power Parity between the UK and the Euro Area

    OpenAIRE

    Giorgio Canarella; Stephen M. Miller; Stephen K. Pollard

    2012-01-01

    We use the Johansen cointegration approach to assess the empirical validity of the purchasing power parity (PPP) between the UK and the Euro Area, which we represent by Germany, the largest of its members. We conduct the empirical analysis in the context of the global financial crisis that began in 2007 and find that it directly affects the cointegration space. We fail to validate the Johansen and Juselius (1992) original hypothesis that nonstationarity of the PPP associates with the nonstati...

  5. Testing R-parity with geometry

    Energy Technology Data Exchange (ETDEWEB)

    He, Yang-Hui [Department of Mathematics, City University, London,Northampton Square, London EC1V 0HB (United Kingdom); School of Physics, NanKai University,94 Weijin Road, Tianjin, 300071 (China); Merton College, University of Oxford,Merton Street, OX1 4JD (United Kingdom); Jejjala, Vishnu [Mandelstam Institute for Theoretical Physics, NITheP, and School of Physics,University of the Witwatersrand,1 Jan Smuts Avenue, Johannesburg, WITS 2050 (South Africa); Matti, Cyril [Department of Mathematics, City University, London,Northampton Square, London EC1V 0HB (United Kingdom); Mandelstam Institute for Theoretical Physics, NITheP, and School of Physics,University of the Witwatersrand,1 Jan Smuts Avenue, Johannesburg, WITS 2050 (South Africa); Nelson, Brent D. [Department of Physics, Northeastern University,360 Huntington Avenue, Boston, MA 02115 (United States)

    2016-03-14

    We present a complete classification of the vacuum geometries of all renormalizable superpotentials built from the fields of the electroweak sector of the MSSM. In addition to the Severi and affine Calabi-Yau varieties previously found, new vacuum manifolds are identified; we thereby investigate the geometrical implication of theories which display a manifest matter parity (or R-parity) via the distinction between leptonic and Higgs doublets, and of the lepton number assignment of the right-handed neutrino fields. We find that the traditional R-parity assignments of the MSSM more readily accommodate the neutrino see-saw mechanism with non-trivial geometry than those superpotentials that violate R-parity. However there appears to be no geometrical preference for a fundamental Higgs bilinear in the superpotential, with operators that violate lepton number, such as νHH̄, generating vacuum moduli spaces equivalent to those with a fundamental bilinear.

  6. Local Strategy Improvement for Parity Game Solving

    Directory of Open Access Journals (Sweden)

    Oliver Friedmann

    2010-06-01

    Full Text Available The problem of solving a parity game is at the core of many problems in model checking, satisfiability checking and program synthesis. Some of the best algorithms for solving parity game are strategy improvement algorithms. These are global in nature since they require the entire parity game to be present at the beginning. This is a distinct disadvantage because in many applications one only needs to know which winning region a particular node belongs to, and a witnessing winning strategy may cover only a fractional part of the entire game graph. We present a local strategy improvement algorithm which explores the game graph on-the-fly whilst performing the improvement steps. We also compare it empirically with existing global strategy improvement algorithms and the currently only other local algorithm for solving parity games. It turns out that local strategy improvement can outperform these others by several orders of magnitude.

  7. R-parity from the heterotic string

    International Nuclear Information System (INIS)

    Gaillard, Mary K.

    2004-01-01

    In T-duality invariant effective supergravity with gaugino condensation as the mechanism for supersymmetry breaking, there is a residual discrete symmetry that could play the role of R-parity in supersymmetric extensions of the Standard Model

  8. Little Higgs models and T parity

    International Nuclear Information System (INIS)

    Perelstein, Maxim

    2006-01-01

    Little Higgs models are an interesting extension of the standard model at the TeV scale. They provide a simple and attractive mechanism of electroweak symmetry breaking. We review one of the simplest models of this class, the littlest Higgs model, and its extension with T parity. The model with T parity satisfies precision electroweak constraints without fine-tuning, contains an attractive dark matter candidate, and leads to interesting phenomenology at the Large Hadron Collider (LHC). (author)

  9. Parity non-conservation in atoms

    International Nuclear Information System (INIS)

    Barkov, L.M.

    1982-01-01

    The parity non-conservation discovered in particle physics in 1959 has consequences on the behaviour of atoms illuminated by light of circular polarization. The theoretical treatments of this topic and recent experimental test of detecting the effects of parity non-conservation on atomic physics are listed, reviewed and illustrated. The main experimental results and limits are summarized. Proposed future experiments are discussed. (D.Gy.)

  10. Parity violation in two-nucleon systems

    Energy Technology Data Exchange (ETDEWEB)

    Liu, C.-P., E-mail: cpliu@mail.ndhu.edu.tw [National Dong Hwa University, Department of Physics (China)

    2013-03-15

    Nuclear few-body systems become attractive avenues for the study of low-energy parity violation because experiments start to meet the precision requirements and theoretical calculations can be performed reliably. In this talk, an attempt of parametrizing low-energy parity-violating observables by the Danilov parameters will be introduced. Analyses of two-nucleon observables, based on the modern phenomenological potentials or the one of effective field theory, will be discussed.

  11. Genotype-Phenotype Study of the Middle Gangetic Plain in India Shows Association of rs2470102 with Skin Pigmentation.

    Science.gov (United States)

    Mishra, Anshuman; Nizammuddin, Sheikh; Mallick, Chandana Basu; Singh, Sakshi; Prakash, Satya; Siddiqui, Niyamat Ali; Rai, Niraj; Carlus, S Justin; Sudhakar, Digumarthi V S; Tripathi, Vishnu P; Möls, Märt; Kim-Howard, Xana; Dewangan, Hemlata; Mishra, Abhishek; Reddy, Alla G; Roy, Biswajit; Pandey, Krishna; Chaubey, Gyaneshwer; Das, Pradeep; Nath, Swapan K; Singh, Lalji; Thangaraj, Kumarasamy

    2017-03-01

    Our understanding of the genetics of skin pigmentation has been largely skewed towards populations of European ancestry, imparting less attention to South Asian populations, who behold huge pigmentation diversity. Here, we investigate skin pigmentation variation in a cohort of 1,167 individuals in the Middle Gangetic Plain of the Indian subcontinent. Our data confirm the association of rs1426654 with skin pigmentation among South Asians, consistent with previous studies, and also show association for rs2470102 single nucleotide polymorphism. Our haplotype analyses further help us delineate the haplotype distribution across social categories and skin color. Taken together, our findings suggest that the social structure defined by the caste system in India has a profound influence on the skin pigmentation patterns of the subcontinent. In particular, social category and associated single nucleotide polymorphisms explain about 32% and 6.4%, respectively, of the total phenotypic variance. Phylogeography of the associated single nucleotide polymorphisms studied across 52 diverse populations of the Indian subcontinent shows wide presence of the derived alleles, although their frequencies vary across populations. Our results show that both polymorphisms (rs1426654 and rs2470102) play an important role in the skin pigmentation diversity of South Asians. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  12. Parity and the medicalization of addiction treatment.

    Science.gov (United States)

    Roy, Ken; Miller, Michael

    2010-06-01

    Parity, the idea that insurance coverage for the treatment of addiction should be on a par with insurance coverage for the treatment of other medical illnesses, is not a new idea, but the path to achieving "real parity" has been a long, hard and complex journey. Action by Congress to pass major parity legislation in 2008 was a huge step forward, but does not mean that parity has been achieved. Parity has required a paradigm shift in the understanding of addiction as a biological illness: many developments of science and policy changes by professional organizations and governmental entities have contributed to that paradigm shift. Access to adequate treatment for patients must acknowledge the paradigm shift reflected in parity as it has evolved to the current point: that this biological illness is widespread, that it is important that it be treated effectively, that appropriate third party payment for physician-provided or physician-supervised addiction treatment is critical for addiction medicine to become a part of the mainstream of our nation's healthcare delivery system, and that medical specialty care provides the most effective and cost effective benefit to patients and therefore to our society.

  13. Investigations on the parity of Fano resonances in photonic crystals

    DEFF Research Database (Denmark)

    Østerkryger, Andreas Dyhl; de Lasson, Jakob Rosenkrantz; Yu, Yi

    We investigate the relation between the parity of Fano resonances and field distribution in a photonic crystal structure using Fourier modal method, establishing a correlation between Fano parity and field profile.......We investigate the relation between the parity of Fano resonances and field distribution in a photonic crystal structure using Fourier modal method, establishing a correlation between Fano parity and field profile....

  14. Localized tachyon condensation and G-parity conservation

    International Nuclear Information System (INIS)

    Lee, Sunggeun; Sin, Sang-Jin

    2004-01-01

    We study the condensation of localized tachyon in non-supersymmetric orbifold. We first show that the G-parity of chiral primaries are preserved under the condensation of localized tachyon (CLT). Using this, we finalize the proof of the conjecture that the lowest-tachyon-mass-squared increases under CLT at the level of type II string with full consideration of GSO projection. We also show the equivalence between the G-parity given by G [jk 1 /n]+[jk 2 /n] coming from partition function and that given by G={jk 1 /n}+k 2 -{jk 2 -/n}k 1 coming from the monomial construction for the chiral primaries in the dual Mirror picture. (author)

  15. Can R-parity violation hide vanilla supersymmetry at the LHC?

    International Nuclear Information System (INIS)

    Asano, Masaki

    2012-09-01

    Current experimental constraints on a large parameter space in supersymmetric models rely on the large missing energy signature. This is usually provided by the lightest neutralino which stability is ensured by the R-parity. However, if the R-parity is violated, the lightest neutralino decays into the standard model particles and the missing energy cut is not efficient anymore. In particular, the UDD type R-parity violation induces the neutralino decay to three quarks which potentially leads to the most difficult signal to be searched at hadron colliders. In this paper, we study the constraints on the R-parity violating supersymmetric models using a same-sign dilepton and a multijet signatures. We show that the gluino and squarks lighter than a TeV are already excluded in constrained minimal supersymmetric standard model with R-parity violation if their masses are approximately equal. We also analyze constraints in a simplified model with R-parity violation. We compare how R-parity violation changes some of the observables typically used to distinguish a supersymmetric signal from standard model backgrounds.

  16. Odd-even parity splittings and octupole correlations in neutron-rich Ba isotopes

    Science.gov (United States)

    Fu, Y.; Wang, H.; Wang, L.-J.; Yao, J. M.

    2018-02-01

    The odd-even parity splittings in low-lying parity-doublet states of atomic nuclei with octupole correlations have usually been interpreted as rotational excitations on top of octupole vibration in the language of collective models. In this paper, we report a deep analysis of the odd-even parity splittings in the parity-doublet states of neutron-rich Ba isotopes around neutron number N =88 within a full microscopic framework of beyond-mean-field multireference covariant energy density functional theory. The dynamical correlations related to symmetry restoration and quadrupole-octupole shape fluctuation are taken into account with a generator coordinate method combined with parity, particle-number, and angular-momentum projections. We show that the behavior of odd-even parity splittings is governed by the interplay of rotation, quantum tunneling, and shape evolution. Similar to 224Ra, a picture of rotation-induced octupole shape stabilization in the positive-parity states is exhibited in the neutron-rich Ba isotopes.

  17. Can R-parity violation hide vanilla supersymmetry at the LHC?

    Energy Technology Data Exchange (ETDEWEB)

    Asano, Masaki [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Rolbiecki, Krzysztof; Sakurai, Kazuki [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2012-09-15

    Current experimental constraints on a large parameter space in supersymmetric models rely on the large missing energy signature. This is usually provided by the lightest neutralino which stability is ensured by the R-parity. However, if the R-parity is violated, the lightest neutralino decays into the standard model particles and the missing energy cut is not efficient anymore. In particular, the UDD type R-parity violation induces the neutralino decay to three quarks which potentially leads to the most difficult signal to be searched at hadron colliders. In this paper, we study the constraints on the R-parity violating supersymmetric models using a same-sign dilepton and a multijet signatures. We show that the gluino and squarks lighter than a TeV are already excluded in constrained minimal supersymmetric standard model with R-parity violation if their masses are approximately equal. We also analyze constraints in a simplified model with R-parity violation. We compare how R-parity violation changes some of the observables typically used to distinguish a supersymmetric signal from standard model backgrounds.

  18. Impact of comprehensive insurance parity on follow-up care after psychiatric inpatient treatment in Oregon.

    Science.gov (United States)

    Wallace, Neal T; McConnell, K John

    2013-10-01

    This study assessed the impact of Oregon's 2007 parity law, which required behavioral health insurance parity, on rates of follow-up care provided within 30 days of psychiatric inpatient care. Data sources were claims (2005-2008) for 737 individuals with inpatient stays for a mental disorder who were continuously enrolled in insurance plans affected by the parity law (intervention group) or in commercial, self-insured plans that were not affected by the law (control group). A difference-in-difference analysis was used to compare rates of follow-up care before and after the parity law between discharges of individuals in the intervention group and the control group and between discharges of individuals in the intervention group who had or had not met preparity quantitative coverage limits during a coverage year. Estimates of the marginal effects of the parity law were adjusted for gender, discharge diagnosis, relationship to policy holder, and calendar quarter of discharge. The study included 353 discharges in the intervention group and 535 discharges in the control group. After the parity law, follow-up rates increased by 11% (p=.042) overall and by 20% for discharges of individuals who had met coverage limits (p=.028). The Oregon parity law was associated with a large increase in the rate of follow-up care, predominantly for discharges of individuals who had met preparity quantitative coverage limits. Given similarities between the law and the 2008 Mental Health Parity and Addiction Equity Act, the results may portend a national effect of more comprehensive parity laws.

  19. Successful attack on permutation-parity-machine-based neural cryptography.

    Science.gov (United States)

    Seoane, Luís F; Ruttor, Andreas

    2012-02-01

    An algorithm is presented which implements a probabilistic attack on the key-exchange protocol based on permutation parity machines. Instead of imitating the synchronization of the communicating partners, the strategy consists of a Monte Carlo method to sample the space of possible weights during inner rounds and an analytic approach to convey the extracted information from one outer round to the next one. The results show that the protocol under attack fails to synchronize faster than an eavesdropper using this algorithm.

  20. Bacteria Associated to Plants Naturally Selected in a Historical PCB Polluted Soil Show Potential to Sustain Natural Attenuation.

    Science.gov (United States)

    Vergani, Lorenzo; Mapelli, Francesca; Marasco, Ramona; Crotti, Elena; Fusi, Marco; Di Guardo, Antonio; Armiraglio, Stefano; Daffonchio, Daniele; Borin, Sara

    2017-01-01

    The exploitation of the association between plants and microorganisms is a promising approach able to boost natural attenuation processes for soil clean-up in vast polluted areas characterized by mixed chemical contamination. We aimed to explore the selection of root-associated bacterial communities driven by different plant species spontaneously established in abandoned agricultural soils within a historical polluted site in north Italy. The site is highly contaminated by chlorinated persistent organic pollutants, mainly constituted by polychlorobiphenyls (PCBs), together with heavy metals and metalloids, in variable concentrations and uneven distribution. The overall structure of the non-vegetated and root-associated soil fractions bacterial communities was described by high-throughput sequencing of the 16S rRNA gene, and a collection of 165 rhizobacterial isolates able to use biphenyl as unique carbon source was assayed for plant growth promotion (PGP) traits and bioremediation potential. The results showed that the recruitment of specific bacterial communities in the root-associated soil fractions was driven by both soil fractions and plant species, explaining 21 and 18% of the total bacterial microbiome variation, respectively. PCR-based detection in the soil metagenome of bacterial bphA gene, encoding for the biphenyl dioxygenase α subunit, indicated that the soil in the site possesses metabolic traits linked to PCB degradation. Biphenyl-utilizing bacteria isolated from the rhizosphere of the three different plant species showed low phylogenetic diversity and well represented functional traits, in terms of PGP and bioremediation potential. On average, 72% of the strains harbored the bphA gene and/or displayed catechol 2,3-dioxygenase activity, involved in aromatic ring cleavage. PGP traits, including 1-aminocyclopropane-1-carboxylic acid deaminase activity potentially associated to plant stress tolerance induction, were widely distributed among the isolates

  1. Bacteria Associated to Plants Naturally Selected in a Historical PCB Polluted Soil Show Potential to Sustain Natural Attenuation

    KAUST Repository

    Vergani, Lorenzo

    2017-07-25

    The exploitation of the association between plants and microorganisms is a promising approach able to boost natural attenuation processes for soil clean-up in vast polluted areas characterized by mixed chemical contamination. We aimed to explore the selection of root-associated bacterial communities driven by different plant species spontaneously established in abandoned agricultural soils within a historical polluted site in north Italy. The site is highly contaminated by chlorinated persistent organic pollutants, mainly constituted by polychlorobiphenyls (PCBs), together with heavy metals and metalloids, in variable concentrations and uneven distribution. The overall structure of the non-vegetated and root-associated soil fractions bacterial communities was described by high-throughput sequencing of the 16S rRNA gene, and a collection of 165 rhizobacterial isolates able to use biphenyl as unique carbon source was assayed for plant growth promotion (PGP) traits and bioremediation potential. The results showed that the recruitment of specific bacterial communities in the root-associated soil fractions was driven by both soil fractions and plant species, explaining 21 and 18% of the total bacterial microbiome variation, respectively. PCR-based detection in the soil metagenome of bacterial bphA gene, encoding for the biphenyl dioxygenase α subunit, indicated that the soil in the site possesses metabolic traits linked to PCB degradation. Biphenyl-utilizing bacteria isolated from the rhizosphere of the three different plant species showed low phylogenetic diversity and well represented functional traits, in terms of PGP and bioremediation potential. On average, 72% of the strains harbored the bphA gene and/or displayed catechol 2,3-dioxygenase activity, involved in aromatic ring cleavage. PGP traits, including 1-aminocyclopropane-1-carboxylic acid deaminase activity potentially associated to plant stress tolerance induction, were widely distributed among the isolates

  2. Bacteria Associated to Plants Naturally Selected in a Historical PCB Polluted Soil Show Potential to Sustain Natural Attenuation

    Directory of Open Access Journals (Sweden)

    Lorenzo Vergani

    2017-07-01

    Full Text Available The exploitation of the association between plants and microorganisms is a promising approach able to boost natural attenuation processes for soil clean-up in vast polluted areas characterized by mixed chemical contamination. We aimed to explore the selection of root-associated bacterial communities driven by different plant species spontaneously established in abandoned agricultural soils within a historical polluted site in north Italy. The site is highly contaminated by chlorinated persistent organic pollutants, mainly constituted by polychlorobiphenyls (PCBs, together with heavy metals and metalloids, in variable concentrations and uneven distribution. The overall structure of the non-vegetated and root-associated soil fractions bacterial communities was described by high-throughput sequencing of the 16S rRNA gene, and a collection of 165 rhizobacterial isolates able to use biphenyl as unique carbon source was assayed for plant growth promotion (PGP traits and bioremediation potential. The results showed that the recruitment of specific bacterial communities in the root-associated soil fractions was driven by both soil fractions and plant species, explaining 21 and 18% of the total bacterial microbiome variation, respectively. PCR-based detection in the soil metagenome of bacterial bphA gene, encoding for the biphenyl dioxygenase α subunit, indicated that the soil in the site possesses metabolic traits linked to PCB degradation. Biphenyl-utilizing bacteria isolated from the rhizosphere of the three different plant species showed low phylogenetic diversity and well represented functional traits, in terms of PGP and bioremediation potential. On average, 72% of the strains harbored the bphA gene and/or displayed catechol 2,3-dioxygenase activity, involved in aromatic ring cleavage. PGP traits, including 1-aminocyclopropane-1-carboxylic acid deaminase activity potentially associated to plant stress tolerance induction, were widely distributed

  3. R-parity-violating production of single top squarks with R-parity-conserving decays

    International Nuclear Information System (INIS)

    Berger, E.L.; Harris, B.W.; Sullivan, Z.

    1999-01-01

    Single-top-squark production probes R-parity-violating extensions of the minimal supersymmetric standard model though the λ 3ij double p rime coupling. For top-squark masses in the range 180-325 GeV, and λ 3ij double p rime > 0.02-0.06, we show that discovery of the top squark is possible with 2 fb -1 of integrated luminosity at run II of the Fermilab Tevatron. The bound on λ 3ij double p rime can be reduced by up to an order of magnitude with existing data from run I, and by two orders of magnitude at run II if the top squark is not found

  4. Gravitino dark matter in R-parity breaking vacua

    Energy Technology Data Exchange (ETDEWEB)

    Buchmueller, W.; Covi, L.; Ibarra, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Hamaguchi, K.; Yanagida, T.T. [Tokyo Univ. (Japan). Dept. of Physics

    2007-02-15

    We show that in the case of small R-parity and lepton number breaking couplings, primordial nucleosynthesis, thermal leptogenesis and gravitino dark matter are naturally consistent for gravitino masses m{sub 3/2} >or similar 5 GeV. We present a model where R-parity breaking is tied to B-L breaking, which predicts the needed small couplings. The metastable next-to-lightest superparticle has a decay length that is typically larger than a few centimeters, with characteristic signatures at the LHC. The photon flux produced by relic gravitino decays may be part of the apparent excess in the extragalactic diffuse gamma-ray flux obtained from the EGRET data for a gravitino mass m{sub 3/2}{proportional_to}10 GeV. In this case, a clear signal can be expected from GLAST in the near future. (orig.)

  5. A Fast Track towards the `Higgs' Spin and Parity

    CERN Document Server

    Ellis, John; Sanz, Veronica; You, Tevong

    2012-01-01

    The LHC experiments ATLAS and CMS have discovered a new boson that resembles the long-sought Higgs boson: it cannot have spin one, and has couplings to other particles that increase with their masses, but the spin and parity remain to be determined. We show here that the `Higgs' + gauge boson invariant-mass distribution in `Higgs'-strahlung events at the Tevatron or the LHC would be very different under the J^P = 0+, 0- and 2+ hypotheses, and could provide a fast-track indicator of the `Higgs' spin and parity. Our analysis is based on simulations of the experimental event selections and cuts using PYTHIA and Delphes, and incorporates statistical samples of `toy' experiments.

  6. Gravitino dark matter in R-parity breaking vacua

    International Nuclear Information System (INIS)

    Buchmueller, W.; Covi, L.; Ibarra, A.; Hamaguchi, K.; Yanagida, T.T.

    2007-02-01

    We show that in the case of small R-parity and lepton number breaking couplings, primordial nucleosynthesis, thermal leptogenesis and gravitino dark matter are naturally consistent for gravitino masses m 3/2 >or similar 5 GeV. We present a model where R-parity breaking is tied to B-L breaking, which predicts the needed small couplings. The metastable next-to-lightest superparticle has a decay length that is typically larger than a few centimeters, with characteristic signatures at the LHC. The photon flux produced by relic gravitino decays may be part of the apparent excess in the extragalactic diffuse gamma-ray flux obtained from the EGRET data for a gravitino mass m 3/2 ∝10 GeV. In this case, a clear signal can be expected from GLAST in the near future. (orig.)

  7. Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A

    DEFF Research Database (Denmark)

    Ricke, C H; Staalsoe, T; Koram, K

    2000-01-01

    -associated malaria (PAM) in endemic areas is concentrated in the first few pregnancies, indicating that protective immunity to PAM is a function of parity. The placenta is often heavily infected in PAM, and placental parasites show a striking preference for chondroitin sulfate A (CSA) as an adhesion receptor. Plasma...

  8. Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations

    Directory of Open Access Journals (Sweden)

    Jéssica Barletto de Sousa Barros

    2018-05-01

    Full Text Available An early immune response to Zika virus (ZIKV infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phase infection. These profiles were then associated with symptoms, revealing important aspects of the immunopathophysiology of ZIKV infection. The levels of some cytokines/chemokines were significantly higher in acute ZIKV-infected individuals compared to healthy donors, including interferon (IFN gamma-induced protein 10 (IP-10, regulated on activation, normal T cell expressed and secreted (RANTES, IFN-γ, interleukin (IL-9, IL-7, IL-5, and IL-1ra, including some with predominantly immunoregulatory activity. Of note, we found that higher levels of IP-10 and IL-5 in ZIKV-infected individuals were strongly associated with exanthema and headache, respectively. Also, higher levels of IL-1ra were associated with subjects with arthralgia, whereas those with fever showed lower levels of granulocyte-colony stimulating factor (G-CSF. No correlation was observed between the number of symptoms and ZIKV viral load. Interestingly, only IP-10 showed significantly decreased levels in the recovery phase. In conclusion, our results indicate that acute ZIKV infection in a larger cohort resident to an endemic area displays a modest systemic immune activation profile, involving both proinflammatory and immunoregulatory cytokines and chemokines that could participate of virus control. In addition, we showed that differential cytokine/chemokine levels are related to specific clinical symptoms, suggesting their participation in underlying mechanisms.

  9. PARITY ODD BUBBLES IN HOT QCD

    International Nuclear Information System (INIS)

    KHARZEEV, D.; PISARSKI, R.D.; TYTGAT, M.H.G.

    1998-01-01

    We consider the topological susceptibility for an SU(N) gauge theory in the limit of a large number of colors, N r a rrow ∞. At nonzero temperature, the behavior of the topological susceptibility depends upon the order of the deconfining phase transition. The most interesting possibility is if the deconfining transition, at T = T d , is of second order. Then we argue that Witten's relation implies that the topological susceptibility vanishes in a calculable fashion at Td. As noted by Witten, this implies that for sufficiently light quark masses, metastable states which act like regions of nonzero θ--parity odd bubbles--can arise at temperatures just below T d . Experimentally, parity odd bubbles have dramatic signatures: the ηprime meson, and especially the η meson, become light, and are copiously produced. Further, in parity odd bubbles, processes which are normally forbidden, such as η r a rrow π 0 π 0 , are allowed. The most direct way to detect parity violation is by measuring a parity odd global asymmetry for charged pions, which we define

  10. PARITY ODD BUBBLES IN HOT QCD.

    Energy Technology Data Exchange (ETDEWEB)

    KHARZEEV,D.; PISARSKI,R.D.; TYTGAT,M.H.G.

    1998-04-16

    We consider the topological susceptibility for an SU(N) gauge theory in the limit of a large number of colors, N {r_arrow} {infinity}. At nonzero temperature, the behavior of the topological susceptibility depends upon the order of the deconfining phase transition. The most interesting possibility is if the deconfining transition, at T = T{sub d}, is of second order. Then we argue that Witten's relation implies that the topological susceptibility vanishes in a calculable fashion at Td. As noted by Witten, this implies that for sufficiently light quark masses, metastable states which act like regions of nonzero {theta}--parity odd bubbles--can arise at temperatures just below T{sub d}. Experimentally, parity odd bubbles have dramatic signatures: the {eta}{prime} meson, and especially the {eta} meson, become light, and are copiously produced. Further, in parity odd bubbles, processes which are normally forbidden, such as {eta} {r_arrow} {pi}{sup 0}{pi}{sup 0}, are allowed. The most direct way to detect parity violation is by measuring a parity odd global asymmetry for charged pions, which we define.

  11. Generating and Solving Symbolic Parity Games

    Directory of Open Access Journals (Sweden)

    Gijs Kant

    2014-07-01

    Full Text Available We present a new tool for verification of modal mu-calculus formulae for process specifications, based on symbolic parity games. It enhances an existing method, that first encodes the problem to a Parameterised Boolean Equation System (PBES and then instantiates the PBES to a parity game. We improved the translation from specification to PBES to preserve the structure of the specification in the PBES, we extended LTSmin to instantiate PBESs to symbolic parity games, and implemented the recursive parity game solving algorithm by Zielonka for symbolic parity games. We use Multi-valued Decision Diagrams (MDDs to represent sets and relations, thus enabling the tools to deal with very large systems. The transition relation is partitioned based on the structure of the specification, which allows for efficient manipulation of the MDDs. We performed two case studies on modular specifications, that demonstrate that the new method has better time and memory performance than existing PBES based tools and can be faster (but slightly less memory efficient than the symbolic model checker NuSMV.

  12. "Ikigai", Subjective Wellbeing, as a Modifier of the Parity-Cardiovascular Mortality Association - The Japan Collaborative Cohort Study.

    Science.gov (United States)

    Yasukawa, Sumiyo; Eguchi, Eri; Ogino, Keiki; Tamakoshi, Akiko; Iso, Hiroyasu

    2018-04-25

    Nulliparity is associated with an excess risk of cardiovascular disease (CVD). "Ikigai", subjective wellbeing in Japan, is associated with reduced risk of CVD. The impact of ikigai on the association between parity and the risk of CVD, however, has not been reported.Methods and Results:A total of 39,870 Japanese women aged 40-79 years without a history of CVD, cancer or insufficient information at baseline in 1988-1990, were enrolled and followed until the end of 2009. They were categorized into 7 groups according to parity number 0-≥6. Using Cox regression hazard modeling, the associations between parity and mortality from stroke, coronary artery disease, and total CVD were investigated. During the follow-up period, 2,121 total CVD deaths were documented. No association was observed between parity and stroke and CVD mortality in women with ikigai, but there was an association in those without ikigai. The multivariable hazard ratios of stroke and total CVD mortality for nulliparous women without ikigai vs. those with 1 child were 1.87 (95% CI: 1.15-3.05) and 1.46 (95% CI: 1.07-2.01), respectively, and that for stroke mortality in high parity women without ikigai was 1.56 (95% CI: 1.00-2.45). Nulliparous or high parity women without ikigai had higher mortality from stroke and/or total CVD, suggesting that ikigai attenuated the association between parity and CVD mortality in Japanese women.

  13. Maternal Parity and Blood Oxidative Stress in Mother and Neonate

    Directory of Open Access Journals (Sweden)

    Golalizadeh

    2016-02-01

    Full Text Available Background Parturition has been associated with free radicals, itself linked with poor pregnancy outcome. Objectives This study aimed to investigate the relationship between oxidative stress biomarkers levels of maternal and cord blood samples at the second stage of labor with the maternal parity number. Materials and Methods In this analytical cross-sectional study, subjects were selected from Fatemieh teaching hospital, Hamadan, Iran, and allocated into the two groups according to their number of parity: the primiparous group (n = 33, and multiparous group (n = 35. Maternal and umbilical cord blood samples were taken from all subjects and then assessed for catalas activity (CAT, total thiol molecules (TTM and total antioxidant capacity (TAC. Results Total antioxidant capacity levels were significantly higher in newborns of primiparous women compared to multiparous women (P = 0.006. The CAT levels were significantly lower (P = 0.04 and TAC levels significantly higher (P = 0.03 in maternal plasma of primiparous women compared to those of multiparous women. Conclusions Increment in the number of parity can lead to decrease antioxidant defense mechanisms in multiparous women and their newborns. So, control of oxidative stress is considered to be beneficial in multiparous women.

  14. Medium effects and parity doubling of hyperons across the deconfinement phase transition*

    Directory of Open Access Journals (Sweden)

    Aarts Gert

    2018-01-01

    Full Text Available We analyse the behaviour of hyperons with strangeness S = –1,–2,–3 in the hadronic and quark gluon plasma phases, with particular interest in parity doubling and its emergence as the temperature grows. This study uses our FASTSUM anisotropic Nf = 2+1 ensembles, with four temperatures below and four above the deconfinement transition temperature, Tc. The positive-parity groundstate masses are found to be largely temperature independent below Tc, whereas the negative-parity ones decrease considerably as the temperature increases. Close to the transition, the masses are almost degenerate, in line with the expectation from chiral symmetry restoration. This may be of interest for heavy-ion phenomenology. In particular we show an application of this effect to the Hadron Resonance Gas model. A clear signal of parity doubling is found above Tc in all hyperon channels, with the strength of the effect depending on the number of s-quarks in the baryons.

  15. Parity and parents' health in later life: the gendered case of Ismailia, Egypt.

    Science.gov (United States)

    Engelman, Michal; Agree, Emily M; Yount, Kathryn M; Bishai, David

    2010-07-01

    We investigate the relationship between reproduction and functional health in later life among women and men in the resource-poor and gender-stratified setting of Ismailia governorate, Egypt. Analyses of survey data collected in 2003 show a statistically significant positive association between parity and difficulty with activities of daily living (ADLs), controlling for demographic and socio-economic factors and other co-morbid conditions. We also find that the number of daughters (but not sons) is associated with worse physical functioning, and this association is more pronounced for older fathers than for older mothers. Our results indicate that both biological and social pathways link fertility and later-life health in this context, and that prescribed familial roles may underlie the differential impact of sons and daughters on the health of mothers and fathers in later life.

  16. Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study.

    Directory of Open Access Journals (Sweden)

    Albertas Dauksa

    Full Text Available Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. Non-invasive early detection would greatly enhance therapy and survival rates. Toward this aim, we investigated in a pilot study the power of methylation changes in whole blood as predictive markers for the detection of pancreatic tumors. We investigated methylation levels at selected CpG sites in the CpG rich regions at the promoter regions of p16, RARbeta, TNFRSF10C, APC, ACIN1, DAPK1, 3OST2, BCL2 and CD44 in the blood of 30 pancreatic tumor patients and in the blood of 49 matching controls. In addition, we studied LINE-1 and Alu repeats using degenerate amplification approach as a surrogate marker for genome-wide methylation. The site-specific methylation measurements at selected CpG sites were done by the SIRPH method. Our results show that in the patient's blood, tumor suppressor genes were slightly but significantly higher methylated at several CpG sites, while repeats were slightly less methylated compared to control blood. This was found to be significantly associated with higher risk for pancreatic ductal adenocarcinoma. Additionally, high methylation levels at TNFRSCF10C were associated with positive perineural spread of tumor cells, while higher methylation levels of TNFRSF10C and ACIN1 were significantly associated with shorter survival. This pilot study shows that methylation changes in blood could provide a promising method for early detection of pancreatic tumors. However, larger studies must be carried out to explore the clinical usefulness of a whole blood methylation based test for non-invasive early detection of pancreatic tumors.

  17. Parity violating nuclear force by meson mixing

    International Nuclear Information System (INIS)

    Iqbal, M.J.; Niskanen, J.A.

    1990-01-01

    We study a mechanism for parity violation in the two nucleon meson-exchange interaction by way of the mixing of mesons of opposite parities. This mixing arises from parity violating W ± and Z exchange between the q bar q pair in the meson. Numerically its effect turns out to be as important as vector meson exchange with a weak meson-nucleon vertex and may partly be used to model this vertex. The calculation is performed using both the standard Born approximation adding the amplitude phases by Watson's theorem and also using the exact correlated two-nucleon wave functions. The effect of correlations and form factors is found to be crucially important at intermediate energies

  18. A multi-centre cohort study shows no association between experienced violence and labour dystocia in nulliparous women at term

    Directory of Open Access Journals (Sweden)

    Dykes Anna-Karin

    2011-02-01

    Full Text Available Abstract Background Although both labour dystocia and domestic violence during pregnancy are associated with adverse maternal and fetal outcome, evidence in support of a possible association between experiences of domestic violence and labour dystocia is sparse. The aim of this study was to investigate whether self-reported history of violence or experienced violence during pregnancy is associated with increased risk of labour dystocia in nulliparous women at term. Methods A population-based multi-centre cohort study. A self-administrated questionnaire collected at 37 weeks of gestation from nine obstetric departments in Denmark. The total cohort comprised 2652 nulliparous women, among whom 985 (37.1% met the protocol criteria for dystocia. Results Among the total cohort, 940 (35.4% women reported experience of violence, and among these, 66 (2.5% women reported exposure to violence during their first pregnancy. Further, 39.5% (n = 26 of those had never been exposed to violence before. Univariate logistic regression analysis showed no association between history of violence or experienced violence during pregnancy and labour dystocia at term, crude OR 0.91, 95% CI (0.77-1.08, OR 0.90, 95% CI (0.54-1.50, respectively. However, violence exposed women consuming alcoholic beverages during late pregnancy had increased odds of labour dystocia, crude OR 1.45, 95% CI (1.07-1.96. Conclusions Our findings indicate that nulliparous women who have a history of violence or experienced violence during pregnancy do not appear to have a higher risk of labour dystocia at term, according to the definition of labour dystocia in this study. Additional research on this topic would be beneficial, including further evaluation of the criteria for labour dystocia.

  19. A multi-centre cohort study shows no association between experienced violence and labour dystocia in nulliparous women at term.

    Science.gov (United States)

    Finnbogadóttir, Hafrún; Dejin-Karlsson, Elisabeth; Dykes, Anna-Karin

    2011-02-21

    Although both labour dystocia and domestic violence during pregnancy are associated with adverse maternal and fetal outcome, evidence in support of a possible association between experiences of domestic violence and labour dystocia is sparse. The aim of this study was to investigate whether self-reported history of violence or experienced violence during pregnancy is associated with increased risk of labour dystocia in nulliparous women at term. A population-based multi-centre cohort study. A self-administrated questionnaire collected at 37 weeks of gestation from nine obstetric departments in Denmark. The total cohort comprised 2652 nulliparous women, among whom 985 (37.1%) met the protocol criteria for dystocia. Among the total cohort, 940 (35.4%) women reported experience of violence, and among these, 66 (2.5%) women reported exposure to violence during their first pregnancy. Further, 39.5% (n = 26) of those had never been exposed to violence before. Univariate logistic regression analysis showed no association between history of violence or experienced violence during pregnancy and labour dystocia at term, crude OR 0.91, 95% CI (0.77-1.08), OR 0.90, 95% CI (0.54-1.50), respectively. However, violence exposed women consuming alcoholic beverages during late pregnancy had increased odds of labour dystocia, crude OR 1.45, 95% CI (1.07-1.96). Our findings indicate that nulliparous women who have a history of violence or experienced violence during pregnancy do not appear to have a higher risk of labour dystocia at term, according to the definition of labour dystocia in this study. Additional research on this topic would be beneficial, including further evaluation of the criteria for labour dystocia.

  20. A multi-centre cohort study shows no association between experienced violence and labour dystocia in nulliparous women at term

    Science.gov (United States)

    2011-01-01

    Background Although both labour dystocia and domestic violence during pregnancy are associated with adverse maternal and fetal outcome, evidence in support of a possible association between experiences of domestic violence and labour dystocia is sparse. The aim of this study was to investigate whether self-reported history of violence or experienced violence during pregnancy is associated with increased risk of labour dystocia in nulliparous women at term. Methods A population-based multi-centre cohort study. A self-administrated questionnaire collected at 37 weeks of gestation from nine obstetric departments in Denmark. The total cohort comprised 2652 nulliparous women, among whom 985 (37.1%) met the protocol criteria for dystocia. Results Among the total cohort, 940 (35.4%) women reported experience of violence, and among these, 66 (2.5%) women reported exposure to violence during their first pregnancy. Further, 39.5% (n = 26) of those had never been exposed to violence before. Univariate logistic regression analysis showed no association between history of violence or experienced violence during pregnancy and labour dystocia at term, crude OR 0.91, 95% CI (0.77-1.08), OR 0.90, 95% CI (0.54-1.50), respectively. However, violence exposed women consuming alcoholic beverages during late pregnancy had increased odds of labour dystocia, crude OR 1.45, 95% CI (1.07-1.96). Conclusions Our findings indicate that nulliparous women who have a history of violence or experienced violence during pregnancy do not appear to have a higher risk of labour dystocia at term, according to the definition of labour dystocia in this study. Additional research on this topic would be beneficial, including further evaluation of the criteria for labour dystocia. PMID:21338523

  1. Preferred axis of CMB parity asymmetry in the masked maps

    International Nuclear Information System (INIS)

    Cheng, Cheng; Zhao, Wen; Huang, Qing-Guo; Santos, Larissa

    2016-01-01

    Both WMAP and Planck data show a significant odd-multipole preference in the large scales of the cosmic microwave background (CMB) temperature anisotropies. If this pattern originates from cosmological effects, then it can be considered a crucial clue for a violation in the cosmological principle. By defining various direction dependent statistics in the full-sky Planck 2015 maps (see, for instance, Naselsky et al. (2012); W. Zhao (2014)), we found that the CMB parity asymmetry has a preferred direction, which is independent of the choices of the statistics. In particular, this preferred axis is strongly aligned with those in the CMB quadrupole and octopole, as well as that in the CMB kinematic dipole, which hints to their non-cosmological origin. In realistic observations, the foreground residuals are inevitable, and should be properly masked out in order to avoid possible misinterpretation of the results. In this paper, we extend our previous analyses to the masked Planck 2015 data. By defining a similar direction dependent statistic in the masked map, we find a preferred direction of the CMB parity asymmetry, in which the axis also coincides with that found in the full-sky analysis. Therefore, our conclusions on the CMB parity violation and its directional properties are confirmed.

  2. Search for supersymmetric particles with R-parity violation

    International Nuclear Information System (INIS)

    Jacquet, M.

    1995-12-01

    Searches for new particles are presented under the assumption that the R-parity, taking the value +1 for all the ordinary particles and -1 for their supersymmetric partners, is not conserved. We suppose that the dominant R-parity violating couplings involve only leptonic fields and that the lifetime of the lightest supersymmetric particle can be neglected. Sleptons, squarks and neutralinos pairs searches have been performed in a data sample collected by the ALEPH detector, at the e + e - collider LEP, from 1989 to 1993. In this statistic, corresponding to almost two million hadronic Ζ decays, no signal was observed. As a result, supersymmetric particle masses and couplings are at least as well constrained as under the usual assumption of R-parity conservation. In a second part, the ALEPH Beam Monitor system (BOMs) is studied. The BOMs, located at 65 m from the ALEPH interaction region, allow the determination of the beam position at the interaction point. The comparison of the 1994 BOM measurements, with the beam position measured by the ALEPH vertex detector, shows sizeable systematic differences. A position monitoring system of the quadrupoles closet to the interaction point has been installed in 1995 and allows the agreement between the BOMs and ALEPH vertex detector data to be improved. Moreover, a new method for the calibration of the electronic ALEPH BOMs system is developed. (author). 54 refs., 75 figs. 15 tabs

  3. Multi-qubit parity measurement in circuit quantum electrodynamics

    International Nuclear Information System (INIS)

    DiVincenzo, David P; Solgun, Firat

    2013-01-01

    We present a concept for performing direct parity measurements on three or more qubits in microwave structures with superconducting resonators coupled to Josephson-junction qubits. We write the quantum-eraser conditions that must be fulfilled for the parity measurements as requirements for the scattering phase shift of our microwave structure. We show that these conditions can be fulfilled with present-day devices. We present one particular scheme, implemented with two-dimensional cavity techniques, in which each qubit should be coupled equally to two different microwave cavities. The magnitudes of the couplings that are needed are in the range that has been achieved in current experiments. A quantum calculation indicates that the measurement is optimal if the scattering signal can be measured with near single-photon sensitivity. A comparison with an extension of a related proposal from cavity optics is presented. We present a second scheme, for which a scalable implementation of the four-qubit parities of the surface quantum error correction code can be envisioned. It uses three-dimensional cavity structures, using cavity symmetries to achieve the necessary multiple resonant modes within a single resonant structure. (paper)

  4. Preferred axis of CMB parity asymmetry in the masked maps

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Cheng [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Science, Beijing 100190 (China); Zhao, Wen, E-mail: wzhao7@ustc.edu.cn [CAS Key Laboratory for Researches in Galaxies and Cosmology, Department of Astronomy, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui 230026 (China); Huang, Qing-Guo [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Science, Beijing 100190 (China); Santos, Larissa [CAS Key Laboratory for Researches in Galaxies and Cosmology, Department of Astronomy, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui 230026 (China)

    2016-06-10

    Both WMAP and Planck data show a significant odd-multipole preference in the large scales of the cosmic microwave background (CMB) temperature anisotropies. If this pattern originates from cosmological effects, then it can be considered a crucial clue for a violation in the cosmological principle. By defining various direction dependent statistics in the full-sky Planck 2015 maps (see, for instance, Naselsky et al. (2012); W. Zhao (2014)), we found that the CMB parity asymmetry has a preferred direction, which is independent of the choices of the statistics. In particular, this preferred axis is strongly aligned with those in the CMB quadrupole and octopole, as well as that in the CMB kinematic dipole, which hints to their non-cosmological origin. In realistic observations, the foreground residuals are inevitable, and should be properly masked out in order to avoid possible misinterpretation of the results. In this paper, we extend our previous analyses to the masked Planck 2015 data. By defining a similar direction dependent statistic in the masked map, we find a preferred direction of the CMB parity asymmetry, in which the axis also coincides with that found in the full-sky analysis. Therefore, our conclusions on the CMB parity violation and its directional properties are confirmed.

  5. Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature.

    Science.gov (United States)

    Herrera, Mercedes; Islam, Abul B M M K; Herrera, Alberto; Martín, Paloma; García, Vanesa; Silva, Javier; Garcia, Jose M; Salas, Clara; Casal, Ignacio; de Herreros, Antonio García; Bonilla, Félix; Peña, Cristina

    2013-11-01

    Cancer-associated fibroblasts (CAF) actively participate in reciprocal communication with tumor cells and with other cell types in the microenvironment, contributing to a tumor-permissive neighborhood and promoting tumor progression. The aim of this study is the characterization of how CAFs from primary human colon tumors promote migration of colon cancer cells. Primary CAF cultures from 15 primary human colon tumors were established. Their enrichment in CAFs was evaluated by the expression of various epithelial and myofibroblast specific markers. Coculture assays of primary CAFs with different colon tumor cells were performed to evaluate promigratory CAF-derived effects on cancer cells. Gene expression profiles were developed to further investigate CAF characteristics. Coculture assays showed significant differences in fibroblast-derived paracrine promigratory effects on cancer cells. Moreover, the association between CAFs' promigratory effects on cancer cells and classic fibroblast activation or stemness markers was observed. CAF gene expression profiles were analyzed by microarray to identify deregulated genes in different promigratory CAFs. The gene expression signature, derived from the most protumorogenic CAFs, was identified. Interestingly, this "CAF signature" showed a remarkable prognostic value for the clinical outcome of patients with colon cancer. Moreover, this prognostic value was validated in an independent series of 142 patients with colon cancer, by quantitative real-time PCR (qRT-PCR), with a set of four genes included in the "CAF signature." In summary, these studies show for the first time the heterogeneity of primary CAFs' effect on colon cancer cell migration. A CAF gene expression signature able to classify patients with colon cancer into high- and low-risk groups was identified.

  6. Mood Dimensions Show Distinct Within-Subject Associations With Non-exercise Activity in Adolescents: An Ambulatory Assessment Study

    Directory of Open Access Journals (Sweden)

    Elena D. Koch

    2018-03-01

    Full Text Available Physical activity is known to preserve both physical and mental health. However, the physical activity levels of a large proportion of adolescents are insufficient. This is critical, since physical activity levels in youth have been shown to translate into adulthood. Whereas in adult populations, mood has been supposed to be one important psychological factor that drives physical activity in everyday life, this issue has been poorly studied in adolescent populations. Ambulatory Assessment is the state-of-the-art approach to investigate how mood and non-exercise activity fluctuate within persons in everyday life. Through assessments in real time and real life, this method provides ecological validity, bypassing several limitations of traditional assessment methods (e.g., recall biases. To investigate whether mood is associated with non-exercise activity in adolescents, we equipped a community-based sample comprising 113 participants, aged 12–17 years, with GPS-triggered e-diaries querying for valence, energetic arousal, and calmness, and with accelerometers continuously measuring physical activity in their everyday lives for 1 week. We excluded all acceleration data due to participants' exercise activities and thereafter we parameterized non-exercise activity as the mean value across 10-min intervals of movement acceleration intensity following each e-diary prompt. We used multilevel analyses to compute the effects of the mood dimensions on non-exercise activity within 10-min intervals directly following each e-diary prompt. Additionally, we conducted explorative analyses of the time course of the effects, i.e., on different timeframes of non-exercise activity up to 300 min following the mood assessment. The results showed that valence (p < 0.001 and energetic arousal (p < 0.001 were positively associated with non-exercise activity within the 10 min interval, whereas calmness (p < 0.001 was negatively associated with non-exercise activity

  7. Parity and risk of lung cancer in women.

    Science.gov (United States)

    Paulus, Jessica K; Asomaning, Kofi; Kraft, Peter; Johnson, Bruce E; Lin, Xihong; Christiani, David C

    2010-03-01

    Patterns of lung cancer incidence suggest that gender-associated factors may influence lung cancer risk. Given the association of parity with risk of some women's cancers, the authors hypothesized that childbearing history may also be associated with lung cancer. Women enrolled in the Lung Cancer Susceptibility Study at Massachusetts General Hospital (Boston, Massachusetts) between 1992 and 2004 (1,004 cases, 848 controls) were available for analysis of the association between parity and lung cancer risk. Multivariate logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals. After results were controlled for age and smoking history, women with at least 1 child had 0.71 times the odds of lung cancer as women without children (odds ratio = 0.71, 95% confidence interval: 0.52, 0.97). A significant linear trend was found: Lung cancer risk decreased with increasing numbers of children (P < 0.001). This inverse association was stronger in never smokers (P = 0.12) and was limited to women over age 50 years at diagnosis (P = 0.17). Age at first birth was not associated with risk. The authors observed a protective association between childbearing and lung cancer, adding to existing evidence that reproductive factors may moderate lung cancer risk in women.

  8. Parity nonconservation in 19 Ne atomic nucleus

    International Nuclear Information System (INIS)

    Popescu, Sorina; Dumitrescu, Ovidiu

    1997-01-01

    The possibility to extract from the experiment the necessary information concerning the charged and neutral current contributions to the structure of the weak interactions that violate the parity conservation law is investigated. The parity nonconservation (PNC) induced by weak hadron-hadron interactions, investigated via 'pairs' of low energy nuclear physics processes, is proposed. The low energy physics processes considered here are emission of polarized gamma rays from oriented and unoriented nuclei. Some comments on PNC nucleon-nucleon (PNC-NN) interaction are presented. Explicit expressions for some gamma asymmetry PNC observables are retrieved. Applications to A=19 atomic nuclei are done. A new experiment is proposed. (authors)

  9. The young Sakharov and his isotopic parity

    International Nuclear Information System (INIS)

    Dalitz, R.H.

    1992-01-01

    In this paper an account is given of A.D. Sakharov's 1947 discovery, while a post-graduate student at F.I.A.N. (Moscow), of his quantum number isotopic parity as a consequence of the charge symmetry of nuclear forces, a property generally accepted as early as 1936. His applications of it are discussed and it is demonstrated from the data today that his tentative suggestion that the small partial width (∼35 eV) for α-decay from 20 Ne (13.649 MeV) to 16 O was due to isotopic parity violation was correct

  10. Parity doubling in the baryon string model

    International Nuclear Information System (INIS)

    Khokhlachev, S.B.

    1990-01-01

    The nature of parity doubling of baryon states with non-zero angular momentum is considered. The idea of explaining this phenomenon lies in the fact that the rotation of the gluon string leads to a centrifugal potential for quarks. The quarks on the string form a quark-diquark system. Quark tunneling from one end of the string to the other is not probable for systems with large angular momentum due to a large centrifugal potential, and the smallness of the underbarrier transition amplitude explains the small mass difference of the states with opposite parity. (orig.)

  11. Res-Parity: Parity Violation in Inelastic scattering at Low Q2

    International Nuclear Information System (INIS)

    Paul Reimer; Peter Bosted; John Arrington; Hamlet Mkrtchyan; Xiaochao Zheng

    2006-01-01

    Parity violating electron scattering has become a well established tool which has been used, for example, to probe the Standard Model and the strange-quark contribution to the nucleon. While much of this work has focused on elastic scattering, the RES-Parity experiment, which has been proposed to take place at Jefferson Laboratory, would focus on inelastic scattering in the low-Q 2 , low-W domain. RES-Parity would search for evidence of quark-hadron duality and resonance structure with parity violation in the resonance region. In terms of parity violation, this region is essentially unexplored, but the interpretation of other high-precision electron scattering experiments will rely on a reasonable understanding of scattering at lower energy and low-W through the effects of radiative corrections. RES-Parity would also study nuclear effects with the weak current. Because of the intrinsic broad band energy spectrum of neutrino beams, neutrino experiments are necessarily dependent on an untested, implicit assumption that these effects are identical to electromagnetic nuclear effects. RES-Parity is a relatively straight forward experiment. With a large expected asymmetry (∼ 0.5 x 10 -4 ) these studies may be completed with in a relatively brief period

  12. Fetal/Placental weight ratio in term Japanese pregnancy: its difference among gender, parity, and infant growth.

    Science.gov (United States)

    Matsuda, Yoshio; Ogawa, Masaki; Nakai, Akihito; Hayashi, Masako; Satoh, Shoji; Matsubara, Shigeki

    2015-01-01

    The "inappropriately heavy placenta" has been considered to be associated with various pregnancy disorders; however, data is scarce what factors affect it. To determine whether the following three affect it; (1) infant gender and mother's parity, (2) growth restriction, and (3) preeclampsia. We employed fetal/placental weight ratio (F/P). Subjects consisted of 53,650 infants and their placentas from women who vaginally delivered singleton live term infants. First, we examined whether F/P differs among the infant's gender or mother's parity. We classified the population into 4 categories according to gender and parity: male, nulliparous (n=7,431), male, multiparous (n=7,859), female, nulliparous (n=7,559), female, multiparous (n=7,800), and, compared F/P among the four groups. Next, we determined whether F/P differs in "small" or "large" for gestational age (SGA or LGA) infants, compared with appropriate for gestational age infants. Last, we determined whether preeclampsia (representative disorder of SGA) affects F/P. (1) F/P significantly differed according to infant gender and parity: female and nulliparity had significantly smaller F/P. F/P was significantly smaller in (2) SGA infants, and (3) infants from preeclamptic mothers. We for the first time showed that in Japanese term vaginally-delivered singleton population, the following three had significantly smaller F/P than controls thus had "inappropriately heavy placenta": (1) female gender and nulliparity, (2) SGA infants, and (3) infants from preeclamptic mothers. We recommend that these factors should be taken into account in evaluating placental weight. These data may also be useful for further clarifying the fetal-placental pathophysiology in these conditions.

  13. Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging.

    Science.gov (United States)

    Law, Matthew H; Medland, Sarah E; Zhu, Gu; Yazar, Seyhan; Viñuela, Ana; Wallace, Leanne; Shekar, Sri Niranjan; Duffy, David L; Bataille, Veronique; Glass, Dan; Spector, Tim D; Wood, Diane; Gordon, Scott D; Barbour, Julie M; Henders, Anjali K; Hewitt, Alex W; Montgomery, Grant W; Sturm, Richard A; Mackey, David A; Green, Adèle C; Martin, Nicholas G; MacGregor, Stuart

    2017-09-01

    Loss of fine skin patterning is a sign of both aging and photoaging. Studies investigating the genetic contribution to skin patterning offer an opportunity to better understand a trait that influences both physical appearance and risk of keratinocyte skin cancer. We undertook a meta-analysis of genome-wide association studies of a measure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,087) drawn from three independent cohorts. We identified that rs185146 near SLC45A2 is associated with a skin aging trait at genome-wide significance (P = 4.1 × 10 -9 ); to our knowledge this is previously unreported. We also confirm previously identified loci, rs12203592 near IRF4 (P = 8.8 × 10 -13 ) and rs4268748 near MC1R (P = 1.2 × 10 -15 ). At all three loci we highlight putative functionally relevant SNPs. There are a number of red hair/low pigmentation alleles of MC1R; we found that together these MC1R alleles explained 4.1% of variance in skin pattern damage. We also show that skin aging and reported experience of sunburns was proportional to the degree of penetrance for red hair of alleles of MC1R. Our work has uncovered genetic contributions to skin aging and confirmed previous findings, showing that pigmentation is a critical determinant of skin aging. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  14. Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

    International Nuclear Information System (INIS)

    Sadikovic, Bekim; Thorner, Paul; Chilton-MacNeill, Susan; Martin, Jeff W; Cervigne, Nilva K; Squire, Jeremy; Zielenska, Maria

    2010-01-01

    Human osteosarcoma is the most common pediatric bone tumor. There is limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis, and a lack of good diagnostic as well as prognostic clinical markers for this disease. Recent discoveries have highlighted a potential role of a number of genes including: RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, P53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L. Our objective was to assess relative expression levels of these 16 genes as potential biomarkers of osteosarcoma oncogenesis and chemotherapy response in human tumors. We performed quantitative expression analysis in a panel of 22 human osteosarcoma tumors with differential response to chemotherapy, and 5 normal human osteoblasts. RECQL4, SPP1, RUNX2, and IBSP were significantly overexpressed, and DOCK5, CDKN1A, RB1, P53, and LSAMP showed significant loss of expression relative to normal osteoblasts. In addition to being overexpressed in osteosarcoma tumor samples relative to normal osteoblasts, RUNX2 was the only gene of the 16 to show significant overexpression in tumors that had a poor response to chemotherapy relative to good responders. These data underscore the loss of tumor suppressive pathways and activation of specific oncogenic mechanisms associated with osteosarcoma oncogenesis, while drawing attention to the role of RUNX2 expression as a potential biomarker of chemotherapy failure in osteosarcoma

  15. Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM.

    Science.gov (United States)

    Alvarez-Twose, Iván; Zanotti, Roberta; González-de-Olano, David; Bonadonna, Patrizia; Vega, Arantza; Matito, Almudena; Sánchez-Muñoz, Laura; Morgado, José Mário; Perbellini, Omar; García-Montero, Andrés; De Matteis, Giovanna; Teodósio, Cristina; Rossini, Maurizio; Jara-Acevedo, María; Schena, Donatella; Mayado, Andrea; Zamò, Alberto; Mollejo, Manuela; Sánchez-López, Paula; Cabañes, Nieves; Orfao, Alberto; Escribano, Luis

    2014-02-01

    Indolent systemic mastocytosis (ISM) without skin lesions (ISMs(-)) shows a higher prevalence in males, lower serum baseline tryptase levels, and KIT mutation more frequently restricted to bone marrow (BM) mast cells (MCs) than ISM with skin lesions (ISMs(+)). Interestingly, in almost one-half of ISMs(-) patients, MC-mediator release episodes are triggered exclusively by insects. We aimed to determine the clinical and laboratory features of ISMs(-) associated with insect-induced anaphylaxis (insectISMs(-)) versus other patients with ISM. A total of 335 patients presenting with MC activation syndrome, including 143 insectISMs(-), 72 ISMs(-) triggered by other factors (otherISMs(-)), 56 ISMs(+), and 64 nonclonal MC activation syndrome, were studied. Compared with otherISMs(-) and ISMs(+) patients, insectISMs(-) cases showed marked male predominance (78% vs 53% and 46%; P < .001), a distinct pattern of MC-related symptoms, and significantly lower median serum baseline tryptase levels (22.4 vs 28.7 and 45.8 μg/L; P ≤ .009). Moreover, insectISMs(-) less frequently presented BM MC aggregates (46% vs 70% and 81%; P ≤ .001), and they systematically showed MC-restricted KIT mutation. ISMs(-) patients with anaphylaxis triggered exclusively by insects display clinical and laboratory features that are significantly different from other ISM cases, including other ISMs(-) and ISMs(+) patients, suggesting that they represent a unique subgroup of ISM with a particularly low BM MC burden in the absence of adverse prognostic factors. Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  16. Parity for mental health and substance abuse care under managed care.

    Science.gov (United States)

    Frank, Richard G.; McGuire, Thomas G.

    1998-12-01

    BACKGROUND: Parity in insurance coverage for mental health and substance abuse has been a key goal of mental health and substance abuse care advocates in the United States during most of the past 20 years. The push for parity began during the era of indemnity insurance and fee for service payment when benefit design was the main rationing device in health care. The central economic argument for enacting legislation aimed at regulating the insurance benefit was to address market failure stemming from adverse selection. The case against parity was based on inefficiency related to moral hazard. Empirical analyses provided evidence that ambulatory mental health services were considerably more responsive to the terms of insurance than were ambulatory medical services. AIMS: Our goal in this research is to reexamine the economics of parity in the light of recent changes in the delivery of health care in the United States. Specifically managed care has fundamentally altered the way in which health services are rationed. Benefit design is now only one mechanism among many that are used to allocate health care resources and control costs. We examine the implication of these changes for policies aimed at achieving parity in insurance coverage. METHOD: We develop a theoretical approach to characterizing rationing under managed care. We then analyze the traditional efficiency concerns in insurance, adverse selection and moral hazard in the context of policy aimed at regulating health and mental health benefits under private insurance. RESULTS: We show that since managed care controls costs and utilization in new ways parity in benefit design no longer implies equal access to and quality of mental health and substance abuse care. Because costs are controlled by management under managed care and not primarily by out of pocket prices paid by consumers, demand response recedes as an efficiency argument against parity. At the same time parity in benefit design may accomplish less

  17. Parity and the spin{statistics connection

    Indian Academy of Sciences (India)

    A simple demonstration of the spin-statistics connection for general causal fields is obtained by using the parity operation to exchange spatial coordinates in the scalar product of a locally commuting field operator, evaluated at position x, with the same field operator evaluated at -x, at equal times.

  18. Parity violation in deep inelastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Souder, P. [Syracuse Univ., NY (United States)

    1994-04-01

    AA beam of polarized electrons at CEBAF with an energy of 8 GeV or more will be useful for performing precision measurements of parity violation in deep inelastic scattering. Possible applications include precision tests of the Standard Model, model-independent measurements of parton distribution functions, and studies of quark correlations.

  19. Parity nonconservation in Zeeman atomic transitions

    International Nuclear Information System (INIS)

    Kraftmakher, A.Ya.

    1990-01-01

    The abilities to observe the parity violation at the radiofrequency transitions between the hyperfine and Zeeman terms of the atomic levels are considered. The E-1 amplitudes fo the Zeeman transitions of heavy atoms in weak magnetic fields are larger, than for the light atoms hyperfine transitions at the same wavelength. 9 refs

  20. Obstacles to Gender Parity in Engineering Education

    Science.gov (United States)

    Rohatynskyj, Marta; Davidson, Valerie; Stiver, Warren; Hayward, Maren

    2008-01-01

    Low rates of women's enrolment in engineering programs has been identified as a global problem within the general concern to enable women to attain parity in education in all areas. A Western women in engineering meta-narrative is identified which contains a complex of obstacles that typify the situation of Western women. The question is asked…

  1. Purchasing Power Parity and Heterogeneous Mean Reversion

    NARCIS (Netherlands)

    C.G. Koedijk (Kees); B. Tims (Ben); M.A. van Dijk (Mathijs)

    2005-01-01

    textabstractThis paper analyzes the properties of multivariate tests of purchasing power parity (PPP) that fail to take heterogeneity in the speed of mean reversion across real exchange rates into account. We compare the performance of homogeneous and heterogeneous unit root testing methodologies.

  2. Purchasing Power Parity and the Euro Area

    NARCIS (Netherlands)

    C.G. Koedijk (Kees); B. Tims (Ben); M.A. van Dijk (Mathijs)

    2004-01-01

    textabstractThis paper analyzes purchasing power parity (PPP) for the euro area. We study the impact of the introduction of the euro in 1999 on the behavior of real exchange rates. We test the PPP hypothesis for a panel of real exchange rates within the euro area over the period 1973-2003. Our

  3. Determination of the K*(1800) spin parity

    Energy Technology Data Exchange (ETDEWEB)

    Brandenburg, G W; Carnegie, R K; Cashmore, R J; Davier, M; Dunwoodie, W M; Lasinski, T A; Leith, D W.G.S.; Matthews, J A.J.; Walden, P; Williams, S H [Stanford Linear Accelerator Center, Calif. (USA)

    1976-02-16

    A spherical harmonic moment analysis of the reactions K/sup -/p..-->..K/sup -/..pi../sup +/n and K/sup +/p..-->..K/sup +/..pi../sup -/..delta../sup + +/ at 13 GeV/c demonstrates the existence of a broad K* state with mass in the vicinity of 1800 MeV and spin parity 3/sup -/.

  4. Parity violation in neutron induced reactions

    International Nuclear Information System (INIS)

    Gudkov, V.P.

    1991-06-01

    The theory of parity violation in neutron induced reactions is discussed. Special attention is paid to the energy dependence and enhancement factors for the various types of nuclear reactions and the information which might be obtained from P-violating effects in nuclei. (author)

  5. Justification of a "Crucial" Experiment: Parity Nonconservation.

    Science.gov (United States)

    Franklin, Allan; Smokler, Howard

    1981-01-01

    Presents history, nature of evidence evaluated, and philosophical questions to justify the view that experiments on parity nonconservation were "crucial" experiments in the sense that they decided unambiguously and within a short period of time for the appropriate scientific community, between two or more competing theories or classes of theories.…

  6. Contraceptive Use: Implication for Completed Fertility, Parity ...

    African Journals Online (AJOL)

    Erah

    NDHS, 2008 dataset on married women aged 45-49 was used. Chi-square ... About 26.0% of the women ever used contraception, while 9.0% of the women were underweight. Parity ..... Working Paper, Labour and Population, 2004. 2.

  7. A measurement of the eta' spin parity

    International Nuclear Information System (INIS)

    Cerrada, M.; Wagner, F.; Chaloupka, V.; Hemingway, R.J.; Holmgren, S.O.; Losty, M.J.; Loverre, P.F.; Marzano, F.; Blokzijl, R.; Jongejans, B.; Massaro, G.G.G.; Schotanus, D.J.; Tiecke, H.G.; Timmermans, J.J.M.; Foster, B.; McDowell, W.L.

    1977-01-01

    The spin parity of the eta'(958) is studied in the reaction K - p→eta'Λ at 4.2 GeV/c, using bubble chamber data with a statistical sensitivity of 128 events/μb. The data unambiguously prefer the 0 - assignment. (Auth.)

  8. A measurement of the eta ' spin parity

    CERN Document Server

    Cerrada, M; Chaloupka, V; Foster, B; Hemingway, R J; Holmgren, S O; Jongejans, B; Losty, Michael J; Loverre, P F; Marzano, F; Massaro, G G G; McDowell, W L; Schotanus, D J; Tiecke, H G; Timmermans, J; Wagner, F

    1977-01-01

    The spin parity of the eta '(958) is studied in the reaction K/sup -/p to eta ' Lambda at 4.2 GeV/c, using bubble chamber data with a statistical sensitivity of 128 events/ mu b. The data unambiguously prefer the 0/sup -/ assignment. (18 refs).

  9. Isolation of baker's yeast mutants with proline accumulation that showed enhanced tolerance to baking-associated stresses.

    Science.gov (United States)

    Tsolmonbaatar, Ariunzaya; Hashida, Keisuke; Sugimoto, Yukiko; Watanabe, Daisuke; Furukawa, Shuhei; Takagi, Hiroshi

    2016-12-05

    During bread-making processes, yeast cells are exposed to baking-associated stresses such as freeze-thaw, air-drying, and high-sucrose concentrations. Previously, we reported that self-cloning diploid baker's yeast strains that accumulate proline retained higher-level fermentation abilities in both frozen and sweet doughs than the wild-type strain. Although self-cloning yeasts do not have to be treated as genetically modified yeasts, the conventional methods for breeding baker's yeasts are more acceptable to consumers than the use of self-cloning yeasts. In this study, we isolated mutants resistant to the proline analogue azetidine-2-carboxylate (AZC) derived from diploid baker's yeast of Saccharomyces cerevisiae. Some of the mutants accumulated a greater amount of intracellular proline, and among them, 5 mutants showed higher cell viability than that observed in the parent wild-type strain under freezing or high-sucrose stress conditions. Two of them carried novel mutations in the PRO1 gene encoding the Pro247Ser or Glu415Lys variant of γ-glutamyl kinase (GK), which is a key enzyme in proline biosynthesis in S. cerevisiae. Interestingly, we found that these mutations resulted in AZC resistance of yeast cells and desensitization to proline feedback inhibition of GK, leading to intracellular proline accumulation. Moreover, baker's yeast cells expressing the PRO1 P247S and PRO1 E415K gene were more tolerant to freezing stress than cells expressing the wild-type PRO1 gene. The approach described here could be a practical method for the breeding of proline-accumulating baker's yeasts with higher tolerance to baking-associated stresses. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Measuring nuclear-spin-dependent parity violation with molecules: Experimental methods and analysis of systematic errors

    Science.gov (United States)

    Altuntaş, Emine; Ammon, Jeffrey; Cahn, Sidney B.; DeMille, David

    2018-04-01

    Nuclear-spin-dependent parity violation (NSD-PV) effects in atoms and molecules arise from Z0 boson exchange between electrons and the nucleus and from the magnetic interaction between electrons and the parity-violating nuclear anapole moment. It has been proposed to study NSD-PV effects using an enhancement of the observable effect in diatomic molecules [D. DeMille et al., Phys. Rev. Lett. 100, 023003 (2008), 10.1103/PhysRevLett.100.023003]. Here we demonstrate highly sensitive measurements of this type, using the test system 138Ba19F. We show that systematic errors associated with our technique can be suppressed to at least the level of the present statistical sensitivity. With ˜170 h of data, we measure the matrix element W of the NSD-PV interaction with uncertainty δ W /(2 π )<0.7 Hz for each of two configurations where W must have different signs. This sensitivity would be sufficient to measure NSD-PV effects of the size anticipated across a wide range of nuclei.

  11. Theory of even-parity states and two-photon spectra of conjugated polymers

    Science.gov (United States)

    McWilliams, P. C. M.; Hayden, G. W.; Soos, Z. G.

    1991-04-01

    The two-photon absorption (TPA) spectrum of interacting π electrons in conjugated polymers is shown to be qualitatively different from any single-particle description, including the Hartree-Fock limit. Alternating transfer integrals t(1+/-δ) along the backbone lead to a weak TPA below the one-photon gap Eg for arbitrarily weak correlations at δ=0, for intermediate correlations at δ=0.07 in polyenes, and for strong correlations at any δtheory to Eg in the limit of strong correlations in Hubbard models and is around 1.5Eg for Pariser-Parr-Pople (PPP) parameters. The PPP model, which accounts for one- and two-photon excitations of finite polyenes, is extended to even-parity states in polydiacetylenes (PDA's), polyacetylene (PA), and polysilanes (PS's). Previous experimental data for PDA and PS support both the strong TPA above Eg and weak TPA slightly below Eg for δ=0.15 in PDA and above Eg for δ~0.3 in PS. The strong TPA expected around 1.5Eg in isolated PA strands shifts to ~Eg due to interchain π-electron dispersion forces. TPA intensities in correlated states are shown to reflect both ionicity and mean-square charge separation. The even-parity states of conjugated polymers, like those of polyenes, show qualitatively different features associated with electron-electron correlations.

  12. Collective properties of nucleons in the abnormal-parity states

    International Nuclear Information System (INIS)

    Bhatt, K. H.; Kahane, S.; Raman, S.

    2000-01-01

    In the first part of this work, we study the quadrupole collective properties of N a =2, 4, 6, and 8 nucleons occupying the abnormal-parity intruder single-particle states with high angular momenta j a =(9/2), (11/2), (13/2), and (15/2). This study is essential for a detailed understanding of the contribution made by these nucleons to the quadrupole collectivity of the yrast states of deformed nuclei. The properties studied include (i) the distribution of the angular momenta J contained in the intrinsic state of N a particles in the |j a k a > states, (ii) the relationship between the quadrupole moment Q 0 (j a ,N a ) of such an intrinsic state and the maximum angular momentum J max contained in it, (iii) the complete set of reduced quadrupole matrix elements (J ' ||Q||J) for transitions between all the states |J> and |J ' > projected from the intrinsic state, (iv) the B(E2:J→J-2) values, (v) the transition moments Q t (J), and (vi) the spectroscopic quadrupole moment Q(J). We compare these properties with similar properties of an intrinsic state having SU(3) symmetry which contains the same set of angular momenta as contained in the intrinsic state of a particular number of nucleons in a specific j a configuration. In the second part, we use the input from the first part to study the collective properties of the coupled system of protons and neutrons in abnormal-parity states. We show that the SU(3)-like features observed for the individual groups of abnormal-parity nucleons become stronger for the coupled system. Finally, in the third part, we consider the yrast bands of well-deformed nuclei projected from their Nilsson intrinsic states of valence nucleons in a major shell. We specify the structure of the wave function of each projected yrast state |J> in terms of the nucleons in both normal- and abnormal-parity states. These wave functions can be used to determine the individual contributions of the nucleons in normal- and abnormal-parity states to any

  13. The Influence of International Parity on the Exchange Rate: Purchasing Power Parity and International Fisher Effect

    OpenAIRE

    Oana Mionel

    2012-01-01

    This article assesses the impact of the inflation and interest rates on the exchange rates. The analysis tests the relation between the inflation rate and the exchange rate by applying the Purchasing Power Parity Theory, while the relation between the interest rate and the inflation rate is tested by applying the International Fisher Effect Theory. In order to test the Purchasing Power Parity the study takes into account the period of time between 1990 – 2009, and the following countries – th...

  14. Polymorphism in promoter of SIX4 gene shows association with its transcription and body measurement traits in Qinchuan cattle.

    Science.gov (United States)

    Wei, Dawei; Raza, Sayed Haidar Abbas; Zhang, Jiupan; Gui, Linsheng; Rahman, Siddiq Ur; Khan, Rajwali; Hosseini, Seyed Mahdi; Kaleri, Hubdar Ali; Zan, Linsen

    2018-05-20

    The sine oculis homeobox homolog 4 (SIX4) gene belongs to the SIX gene family, which plays a critical role in muscle regeneration and early stages of ontogeny. This study aimed to detect promoter variations of bovine SIX4 genes in Qinchuan cattle, and to evaluate the effect of transcription regulations and body measurement traits. Quantitative real-time PCR (qPCR) results showed that the mRNA expression levels of SIX4 gene were found significantly highest in longissimus thoracis tissue and individual before attaining the stage of physiological maturity. Using sequencing technology on a total of 428 Qinchuan cattle, seven single nucleotide polymorphisms (SNPs) were identified in the promoter region of SIX4, and seven haplotypes representing 18 potential transcription factor compositions of polymorphic potential cis-acting elements. Association analysis indicated that the H 3 -H 3 diplotype performed greater withers height, chest depth, chest circumference, back fat thickness and ultrasound loin muscle area (P cattle. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Judging children's participatory parity from social justice and the ...

    African Journals Online (AJOL)

    This article proposes a model for judging children's participatory parity in different social spaces. The notion of participatory parity originates in Nancy Fraser's normative theory for social justice, where it concerns the participatory status of adults. What, then, constitutes participatory parity for children? How should we judge ...

  16. Perspectives: parity--prelude to a fifth cycle of reform.

    Science.gov (United States)

    Goldman, Howard H

    2002-09-01

    Based on 2000 Carl Taube Lecture at the NIMH Mental Health Economics Meeting. This perspective article examines the relationship between a policy of parity in financing mental health services and the future of reform in service delivery. Applying theories of static and dynamic efficiency to an understanding of parity and the evolution of mental health services, drawing upon Burton Weisbrod s concept of the health care quadrilemma . Each of four cycles of reform in mental health services have contended with issues of static and dynamic efficiency. Each cycle was associated with static efficiency in the management and financing of services, and each was associated with a set of new treatment technologies intended to improve dynamic efficiency. Each reform proved ultimately unsuccessful primarily because of the failure of the treatment technologies to prevent future patient chronicity or to achieve sustained recovery. Recent advances in treatment technology and management of care can permit an unprecedented level of efficiency consistent with a policy of improved access to mainstream health and social welfare resources, including insurance coverage. This policy of so-called financing parity can improve current mental health service delivery, but it may also portend a future fifth cycle of reform. If new technologies continue to advance as full technologies - simple to deliver and producing true recovery - and mainstream resources are made available, then the specialty mental health services may contract dramatically in favor of effective care and treatment of mental illness in primary care and other mainstream settings. Predicting the future of health care is speculative, but it may be easier using the Weisbrod formulation to understand the process of mental health reform. Over-reliance on administrative techniques for building static efficiency and false optimism about dynamic efficiency from new technology have stymied previous reforms. All the same, a fifth cycle

  17. Climatic associations of British species distributions show good transferability in time but low predictive accuracy for range change.

    Directory of Open Access Journals (Sweden)

    Giovanni Rapacciuolo

    Full Text Available Conservation planners often wish to predict how species distributions will change in response to environmental changes. Species distribution models (SDMs are the primary tool for making such predictions. Many methods are widely used; however, they all make simplifying assumptions, and predictions can therefore be subject to high uncertainty. With global change well underway, field records of observed range shifts are increasingly being used for testing SDM transferability. We used an unprecedented distribution dataset documenting recent range changes of British vascular plants, birds, and butterflies to test whether correlative SDMs based on climate change provide useful approximations of potential distribution shifts. We modelled past species distributions from climate using nine single techniques and a consensus approach, and projected the geographical extent of these models to a more recent time period based on climate change; we then compared model predictions with recent observed distributions in order to estimate the temporal transferability and prediction accuracy of our models. We also evaluated the relative effect of methodological and taxonomic variation on the performance of SDMs. Models showed good transferability in time when assessed using widespread metrics of accuracy. However, models had low accuracy to predict where occupancy status changed between time periods, especially for declining species. Model performance varied greatly among species within major taxa, but there was also considerable variation among modelling frameworks. Past climatic associations of British species distributions retain a high explanatory power when transferred to recent time--due to their accuracy to predict large areas retained by species--but fail to capture relevant predictors of change. We strongly emphasize the need for caution when using SDMs to predict shifts in species distributions: high explanatory power on temporally-independent records

  18. A Resolution of the Purchasing Power Parity Puzzle

    DEFF Research Database (Denmark)

    Frydman, Roman; Goldberg, Michael D.; Johansen, Søren

    Asset prices undergo long swings that revolve around benchmark levels. In currency markets, fluctuations involve real exchange rates that are highly persistent and that move in near-parallel fashion with nominal rates. The inability to explain these two regularities with one model has been called...... the "Purchasing Power Parity puzzle". In this paper, we trace the puzzle to exchange rate modelers' use of the "Rational Expectations Hypothesis". We show that once imperfect knowledge is recognized, a monetary model is able to account for the puzzle, as well as other salient features of the data, including...

  19. Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

    NARCIS (Netherlands)

    Middelberg, R.P.S.; Benyamin, B.; de Moor, M.H.M.; Warrington, N.M.; Gordon, S.; Henders, A.K.; Medland, S.E.; Nyholt, DR; de Geus, E.J.C.; Hottenga, J.J.; Willemsen, G.; Beilin, L.J.; Mori, T.A.; Wright, M.J.; Heath, A.C.; Madden, P.A.F.; Boomsma, D.I.; Pennell, C.E.; Montgomery, G.W.; Martin, N.G.; Whitfield, J.B.

    2012-01-01

    Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in

  20. Effect of parity on bone mineral density: A systematic review and meta-analysis.

    Science.gov (United States)

    Song, Seung Yeon; Kim, Yejee; Park, Hyunmin; Kim, Yun Joo; Kang, Wonku; Kim, Eun Young

    2017-08-01

    Parity has been suggested as a possible factor affecting bone health in women. However, study results on its association with bone mineral density are conflicting. PubMed, EMBASE, the Cochrane Library, and Korean online databases were searched using the terms "parity" and "bone mineral density", in May 2016. Two independent reviewers extracted the mean and standard deviation of bone mineral density measurements of the femoral neck, spine, and total hip in nulliparous and parous healthy women. Among the initial 10,146 studies, 10 articles comprising 24,771 women met the inclusion criteria. The overall effect of parity on bone mineral density was positive (mean difference=5.97mg/cm 2 ; 95% CI 2.37 to 9.57; P=0.001). The effect appears site-specific as parity was not significantly associated with the bone mineral density of the femoral neck (P=0.09) and lumbar spine (P=0.17), but parous women had significantly higher bone mineral density of the total hip compared to nulliparous women (mean difference=5.98mg/cm 2 ; 95% CI 1.72 to 10.24; P=0.006). No obvious heterogeneity existed among the included studies (femoral neck I 2 =0%; spine I 2 =31%; total hip I 2 =0%). Parity has a positive effect on bone in healthy, community-dwelling women and its effect appears site-specific. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Parity and pancreatic cancer risk: a dose-response meta-analysis of epidemiologic studies.

    Directory of Open Access Journals (Sweden)

    Hong-Bo Guan

    Full Text Available BACKGROUND: Previous epidemiologic studies have reported inconsistent results between parity and pancreatic cancer (PC risk. To our knowledge, a comprehensive and quantitative assessment of this association has not been conducted. METHODS: Relevant published studies of parity and PC were identified using MEDLINE (PubMed and Web of Science databases until November 2013. Two authors (H-BG and LW independently assessed eligibility and extracted data. Eleven prospective and 11 case-control studies reported relative risk (RR estimates and 95% confidence intervals (CIs of PC associated with parity. Fixed- and random-effects models were used to estimate the summary RR depending on the heterogeneity of effects. RESULTS: The summary RR for PC comparing the highest versus lowest parity was 0.86 (95% CI: 0.73-1.02; Q = 50.49, P<0.001, I2 = 58.4%. Significant inverse associations were also observed in the studies that adjusted for cigarette smoking (RR = 0.81; 95% CI: 0.68-0.98, Type 2 diabetes mellitus (RR = 0.83; 95% CI: 0.75-0.93, and those that included all confounders or important risk factors (RR = 0.85; 95% CI: 0.76-0.96. Additionally, in the dose-response analysis, the summary RR for per one live birth was 0.97 (95% CI: 0.94-1.01; Q = 62.83, P<0.001, I2 = 69.8%, which also indicated a borderline statistically significant inverse effect of parity on PC risk. No evidence of publication bias and significant heterogeneity between subgroups were detected by meta-regression analyses. CONCLUSION: In summary, these findings suggest that higher parity is associated with a decreased risk of PC. Future large consortia or pooled studies are warranted to fully adjust for potential confounders to confirm this association.

  2. Coupled oscillators with parity-time symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Tsoy, Eduard N., E-mail: etsoy@uzsci.net

    2017-02-05

    Different models of coupled oscillators with parity-time (PT) symmetry are studied. Hamiltonian functions for two and three linear oscillators coupled via coordinates and accelerations are derived. Regions of stable dynamics for two coupled oscillators are obtained. It is found that in some cases, an increase of the gain-loss parameter can stabilize the system. A family of Hamiltonians for two coupled nonlinear oscillators with PT-symmetry is obtained. An extension to high-dimensional PT-symmetric systems is discussed. - Highlights: • A generalization of a Hamiltonian system of linear coupled oscillators with the parity-time (PT) symmetry is suggested. • It is found that an increase of the gain-loss parameter can stabilize the system. • A family of Hamiltonian functions for two coupled nonlinear oscillators with PT-symmetry is obtained.

  3. Photovoltaic is redolent of grid parity

    International Nuclear Information System (INIS)

    Signoret, Stephane

    2015-01-01

    This article indicates and comments the current trends of decrease of photovoltaic costs and increase of electricity prices. As a result, grid parity is starting to be reached in some countries (Mexico city, California, Australia, Italy, Germany, Israel, Chile) and nearly in southern France only, as the prices of residential electricity are rather low and therefore don't give any chance to network parity for solar photovoltaic. Curves of evolutions of photovoltaic costs and retail electricity prices are given for different towns (Berlin, London, Rome, Madrid, Marseilles, San Francisco, Sydney, and Copiapo in Chile). These evolutions are a positive factor for the development of self-consumption. The article thus evokes the PV-NET project which gathers several European regions or countries to test and assess different economic solutions of self-consumption

  4. Parity nonconservation in two-nucleon systems

    International Nuclear Information System (INIS)

    Nagle, D.E.

    1975-01-01

    The observation of a violation of the parity symmetry in two-nucleon systems implies the presence of a weak hadronic force. The positive effect reported by Lobashov et al. in the reaction np → dγ, for the circular polarization of the gamma ray, would imply a large value for the parity nonconserving (PNC) amplitude. A transmission experiment has been undertaken for 15-MeV longitudinally polarized protons on hydrogen. A transmission experiment for 6-GeV polarized protons on Be and on H 2 O is in progress at the ZGS at Argonne National Laboratory. The current results of the latter two experiments are summarized, and the relation to theoretical calculations is discussed. (2 figures, 1 table) (U.S.)

  5. Parity simulation for nuclear plant analysis

    International Nuclear Information System (INIS)

    Hansen, K.F.; Depiente, E.

    1986-01-01

    The analysis of the transient performance of nuclear plants is sufficiently complex that simulation tools are needed for design and safety studies. The simulation tools are needed for design and safety studies. The simulation tools are normally digital because of the speed, flexibility, generality, and repeatability of digital computers. However, communication with digital computers is an awkward matter, requiring special skill or training. The designer wishing to gain insight into system behavior must expend considerable effort in learning to use computer codes, or else have an intermediary communicate with the machine. There has been a recent development in analog simulation that simplifies the user interface with the simulator, while at the same time improving the performance of analog computers. This development is termed parity simulation and is now in routine use in analyzing power electronic network transients. The authors describe the concept of parity simulation and present some results of using the approach to simulate neutron kinetics problems

  6. Parity nonconserving optical rotation in atomic lead

    International Nuclear Information System (INIS)

    Emmons, T.P. Jr.

    1984-01-01

    A measurement of parity nonconserving optical rotation has been performed on the 1.28 μm atomic lead magnetic dipole transition. Although the technique used in this measurement was similar to that used in earlier measurements done on the 0.876 μm line in atomic bismuth, important differences exist. These are discussed in detail. Since the accuracy of this measurement is limited by systematic errors, a complete analysis of the data is included with a lengthy discussion of systematic effects. The final value obtained for the optical rotation is given. This agrees with atomic calculations based on the Weinberg-Salam-Galshow model for weak interactions. A discussion of the limits on weak interaction theories placed by all the atomic parity nonconservation experiments appears in the conclusion

  7. Bacteria Associated to Plants Naturally Selected in a Historical PCB Polluted Soil Show Potential to Sustain Natural Attenuation

    KAUST Repository

    Vergani, Lorenzo; Mapelli, Francesca; Marasco, Ramona; Crotti, Elena; Fusi, Marco; Di Guardo, Antonio; Armiraglio, Stefano; Daffonchio, Daniele; Borin, Sara

    2017-01-01

    The exploitation of the association between plants and microorganisms is a promising approach able to boost natural attenuation processes for soil clean-up in vast polluted areas characterized by mixed chemical contamination. We aimed to explore

  8. Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression

    DEFF Research Database (Denmark)

    Hamdi, Yosr; Soucy, Penny; Kuchenbaeker, Karoline B

    2017-01-01

    and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most...... studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.......1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast...

  9. Gender Parity in Critical Care Medicine.

    Science.gov (United States)

    Mehta, Sangeeta; Burns, Karen E A; Machado, Flavia R; Fox-Robichaud, Alison E; Cook, Deborah J; Calfee, Carolyn S; Ware, Lorraine B; Burnham, Ellen L; Kissoon, Niranjan; Marshall, John C; Mancebo, Jordi; Finfer, Simon; Hartog, Christiane; Reinhart, Konrad; Maitland, Kathryn; Stapleton, Renee D; Kwizera, Arthur; Amin, Pravin; Abroug, Fekri; Smith, Orla; Laake, Jon H; Shrestha, Gentle S; Herridge, Margaret S

    2017-08-15

    Clinical practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. These documents inform and shape patient care around the world. In this Perspective we discuss the importance of diversity on guideline panels, the disproportionately low representation of women on critical care guideline panels, and existing initiatives to increase the representation of women in corporations, universities, and government. We propose five strategies to ensure gender parity within critical care medicine.

  10. Purchasing power parity a different approach

    OpenAIRE

    Σακελλής, Παναγιώτης

    2001-01-01

    Historically, Purchasing Power Parity (henceforth PPP) provides the simplest explanation of long-run exchange rate determination, according to which the equilibrium exchange rate between domestic and foreign currencies equals the ratio between domestic and foreign prices. A few years ago, PPP validity theory seemed like a fairly dull research topic. On the one hand the unavoidable effects of floating exchange rates made it obvious to even its most stubborn defenders that PPP is not a short-ru...

  11. Odd-parity baryons: progress and problems

    International Nuclear Information System (INIS)

    Cutkosky, R.E.

    1981-01-01

    The odd-parity baryons have provided a graveyard for many cherished ideas about hadrons. The simple quark shell model, with QCD-inspired phenomenological perturbations, is the only model able to describe the states with even partial qualitative success. There are also important unexplained residual dynamical effects. Resonance decays can be accounted for, provided the usual spectator model is abandoned. Better experimental data could help to sort out the many remaining puzzles

  12. Do Firms Believe in Interest Rate Parity?

    OpenAIRE

    Matthew R. McBrady; Sandra Mortal; Michael J. Schill

    2010-01-01

    Using a broad sample of international corporate bond offerings, we provide evidence that corporate borrowers make opportunistic currency choices, in that they denominate the currency of their bonds in a manner that is inconsistent with a belief in either covered or uncovered interest rate parity. Using firm-level tests, we identify a number of characteristics of firms that engage in opportunistic behavior. We observe that large issuers located in developed markets with investment-grade rating...

  13. Nonlinear Trend and Purchasing Power Parity

    OpenAIRE

    luo, yinghao

    2016-01-01

    Abstract. After the collapse of the Bretton Woods system, the evidence on the purchasing power parity (PPP) in the long run is still a matter of debate. The difficulties of the problem are the possible nonstationarity of relative price indices and nominal exchange rates. The traditional ways to deal with nonstationarity such as unit root model and cointegration have some problems. In this paper, to deal with nonstationarity, we apply the Hodrick-Prescott (HP) trend-cycle filter in real busine...

  14. Negative parity non-strange baryons

    International Nuclear Information System (INIS)

    Stancu, F.; Stassart, P.

    1991-01-01

    Our previous study is extended to negative parity baryon resonances up to J=(9/2) - . The framework is a semi-relativistic constituent quark model. The quark-quark interaction contains a Coulomb plus linear confinement terms and a short distance spin-spin and tensor terms. It is emphasized that a linear confinement potential gives too large a mass to the D 35 (1930) resonance. (orig.)

  15. Parity violation in the compound nucleus

    International Nuclear Information System (INIS)

    Mitchell, G. E.; Crawford, B. E.; Grossmann, C. A.; Lowie, L. Y.; Bowman, J. D.; Knudson, J.; Penttilae, S.; Seestrom, S. J.; Smith, D. A.; Yen, Yi-Fen; Yuan, V. W.; Delheij, P. P. J.; Haseyama, T.; Masaike, A.; Matsuda, Y.; Postma, H.; Roberson, N. R.; Sharapov, E. I.; Stephenson, S. L.

    1999-01-01

    Measurements have been performed on the helicity dependence of the neutron resonance cross section for many nuclei by our TRIPLE Collaboration. A large number of parity violations are observed. Generic enhancements amplify the signal for symmetry breaking and the stochastic properties of the compound nucleus permit the strength of the symmetry-breaking interaction to be determined without knowledge of the wave functions of individual states. A total of 15 nuclei have been analyzed with this statistical approach. The results are summarized

  16. Cognition and gait show a selective pattern of association dominated by phenotype in incident Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Sue eLord

    2014-10-01

    Full Text Available Reports outlining the association between gait and cognition in Parkinson’s disease (PD are limited because of methodological issues and a bias towards studying advanced disease. This study examines the association between gait and cognition in 121 early PD who were characterized according to motor phenotype, and 184 healthy older adults. Quantitative gait was captured using a 7m GAITrite walkway whilst walking for two minutes under single task conditions and described by five domains (pace, rhythm, variability, asymmetry and postural control. Cognitive outcomes were summarized by six domains (attention, working memory, visual memory, executive function, visuospatial function and global cognition. Partial correlations and multivariate linear regression were used to determine independent associations for all participants and for PD tremor-dominant (TD and postural instability and gait disorder (PIGD phenotypes, controlling for age, sex, and premorbid intelligence using the National Adult Reading Test (NART. Cognitive and gait outcomes were significantly worse for PD. Gait, but not cognitive outcomes, were selectively worse for the PIGD phenotype. Significant associations emerged for two gait domains for controls (pace and postural control and four gait domains for PD (pace, rhythm, variability, and postural control.The strongest correlation was for pace and attention for PD and controls. Associations were not significant for participants with the TD phenotype. In early PD the cognitive correlates of gait are predominantly with fronto-executive functions, and are determined by the PIGD PD phenotype. These associations provide a basis for understanding the complex role of cognition in Parkinsonian gait.

  17. Quasi Cyclic Low Density Parity Check Code for High SNR Data Transfer

    Directory of Open Access Journals (Sweden)

    M. R. Islam

    2010-06-01

    Full Text Available An improved Quasi Cyclic Low Density Parity Check code (QC-LDPC is proposed to reduce the complexity of the Low Density Parity Check code (LDPC while obtaining the similar performance. The proposed QC-LDPC presents an improved construction at high SNR with circulant sub-matrices. The proposed construction yields a performance gain of about 1 dB at a 0.0003 bit error rate (BER and it is tested on 4 different decoding algorithms. Proposed QC-LDPC is compared with the existing QC-LDPC and the simulation results show that the proposed approach outperforms the existing one at high SNR. Simulations are also performed varying the number of horizontal sub matrices and the results show that the parity check matrix with smaller horizontal concatenation shows better performance.

  18. Excited negative parity bands in 160Yb

    Science.gov (United States)

    Saha, A.; Bhattacharjee, T.; Curien, D.; Dedes, I.; Mazurek, K.; Banerjee, S. R.; Rajbanshi, S.; Bisoi, A.; de Angelis, G.; Bhattacharya, Soumik; Bhattacharyya, S.; Biswas, S.; Chakraborty, A.; Das Gupta, S.; Dey, B.; Goswami, A.; Mondal, D.; Pandit, D.; Palit, R.; Roy, T.; Singh, R. P.; Saha Sarkar, M.; Saha, S.; Sethi, J.

    2018-03-01

    Negative parity rotational bands in {} 70160Yb{}90 nucleus have been studied. They were populated in the 148Sm(16O, 4n)160Yb reaction at 90 MeV. The gamma-coincidence data have been collected using Indian National Gamma Array composed of twenty Compton suppressed clover germanium (Ge) detectors. Double gating on triple gamma coincidence data were selectively used to develop the decay scheme for these negative parity bands by identifying and taking care of the multiplet transitions. The even- and odd-spin negative parity bands in 160Yb have been studied by comparing the reduced transition probability ratios with the similar bands in neighbouring even-even rare earth nuclei. It is concluded that the concerned odd-spin and even-spin bands are not signature partners and that their structures are compatible with those of the ‘pear-shape’ and ‘pyramid-shape’ oscillations, respectively, the octupole shapes superposed with the quadrupole shape of the ground-state.

  19. Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression

    DEFF Research Database (Denmark)

    Hamdi, Yosr; Soucy, Penny; Kuchenbaeker, Karoline B

    2017-01-01

    1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast...... and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most...... significant SNP rs228595 p = 7 × 10(-6)). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1...

  20. Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder

    Directory of Open Access Journals (Sweden)

    Ramos Paula S

    2012-06-01

    Full Text Available Abstract Background A growing number of clinical and basic research studies have implicated immunological abnormalities as being associated with and potentially responsible for the cognitive and behavioral deficits seen in autism spectrum disorder (ASD children. Here we test the hypothesis that immune-related gene loci are associated with ASD. Findings We identified 2,012 genes of known immune-function via Ingenuity Pathway Analysis. Family-based tests of association were computed on the 22,904 single nucleotide polymorphisms (SNPs from the 2,012 immune-related genes on 1,510 trios available at the Autism Genetic Resource Exchange (AGRE repository. Several SNPs in immune-related genes remained statistically significantly associated with ASD after adjusting for multiple comparisons. Specifically, we observed significant associations in the CD99 molecule-like 2 region (CD99L2, rs11796490, P = 4.01 × 10-06, OR = 0.68 (0.58-0.80, in the jumonji AT rich interactive domain 2 (JARID2 gene (rs13193457, P = 2.71 × 10-06, OR = 0.61 (0.49-0.75, and in the thyroid peroxidase gene (TPO (rs1514687, P = 5.72 × 10-06, OR = 1.46 (1.24-1.72. Conclusions This study suggests that despite the lack of a general enrichment of SNPs in immune function genes in ASD children, several novel genes with known immune functions are associated with ASD.

  1. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity

    International Nuclear Information System (INIS)

    Barnett, Gillian C.; Elliott, Rebecca M.; Alsner, Jan; Andreassen, Christian N.; Abdelhay, Osama; Burnet, Neil G.; Chang-Claude, Jenny; Coles, Charlotte E.; Gutiérrez-Enríquez, Sara; Fuentes-Raspall, Maria J.; Alonso-Muñoz, Maria C.; Kerns, Sarah; Raabe, Annette; Symonds, R. Paul; Seibold, Petra; Talbot, Chris J.; Wenz, Frederik; Wilkinson, Jennifer; Yarnold, John; Dunning, Alison M.

    2012-01-01

    Background and purpose: Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in TGFB1, encoding the pro-fibrotic cytokine transforming growth factor-beta 1 (TGF-β1), remain controversial. To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies. Materials and methods: TGFB1 SNP rs1800469 c.-1347T>C (previously known as C-509T) genotype, treatment-related data, and clinically-assessed fibrosis (measured at least 2 years after therapy) were available in 2782 participants from 11 cohorts. All received adjuvant breast radiotherapy. Associations between late fibrosis or overall toxicity, reported by STAT (Standardised Total Average Toxicity) score, and rs1800469 genotype were assessed. Results: No statistically significant associations between either fibrosis or overall toxicity and rs1800469 genotype were observed with univariate or multivariate regression analysis. The multivariate odds ratio (OR), obtained from meta-analysis, for an increase in late fibrosis grade with each additional rare allele of rs1800469 was 0.98 (95% Confidence Interval (CI) 0.85–1.11). This CI is sufficiently narrow to rule out any clinically relevant effect on toxicity risk in carriers vs. non-carriers with a high probability. Conclusion: This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients. It has demonstrated successful collaboration within the Radiogenomics Consortium.

  2. Verbal Short-Term Memory Shows a Specific Association with Receptive but Not Productive Vocabulary Measures in Down Syndrome

    Science.gov (United States)

    Majerus, S.; Barisnikov, K.

    2018-01-01

    Background: Verbal short-term memory (STM) capacity has been considered to support vocabulary learning in typical children and adults, but evidence for this link is inconsistent for studies in individuals with Down syndrome (DS). The aim of this study was explore the role of processing demands on the association between verbal STM and vocabulary…

  3. Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis.

    Science.gov (United States)

    Ma, Kevin C; Unemo, Magnus; Jeverica, Samo; Kirkcaldy, Robert D; Takahashi, Hideyuki; Ohnishi, Makoto; Grad, Yonatan H

    2017-12-01

    Neisseria meningitidis , typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species, N. gonorrhoeae , the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with the gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcus-like and distinguishing them from other N. meningitidis strains. Here, we analyzed the genomes of 39 diverse N. meningitidis isolates associated with urethritis, collected independently over a decade and across three continents. In particular, we characterized the diversity of the nitrite reductase gene ( aniA ), the factor H-binding protein gene ( fHbp ), and the capsule biosynthetic locus, all of which are loci previously suggested to be associated with urogenital colonization. We observed notable diversity, including frameshift variants, in aniA and fHbp and the presence of intact, disrupted, and absent capsule biosynthetic genes, indicating that urogenital colonization and urethritis caused by N. meningitidis are possible across a range of meningococcal genotypes. Previously identified allelic patterns in urethritis-associated N. meningitidis strains may reflect genetic diversity in the underlying meningococcal population rather than novel adaptation to the urogenital tract. Copyright © 2017 American Society for Microbiology.

  4. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

    NARCIS (Netherlands)

    T. Tanaka (Toshiko); J.S. Ngwa; F.J.A. van Rooij (Frank); M.C. Zillikens (Carola); M.K. Wojczynski (Mary ); A.C. Frazier-Wood (Alexis); D.K. Houston (Denise); S. Kanoni (Stavroula); R.N. Lemaitre (Rozenn ); J. Luan; V. Mikkilä (Vera); F. Renström (Frida); E. Sonestedt (Emily); J.H. Zhao (Jing Hua); A.Y. Chu (Audrey); L. Qi (Lu); D.I. Chasman (Daniel); M.C. De Oliveira Otto (Marcia); E.J. Dhurandhar (Emily); M.F. Feitosa (Mary Furlan); I. Johansson (Ingegerd); K-T. Khaw (Kay-Tee); K. Lohman (Kurt); A. Manichaikul (Ani); N.M. McKeown (Nicola ); D. Mozaffarian (Dariush); A.B. Singleton (Andrew); K. Stirrups (Kathy); J. Viikari (Jorma); Z. Ye (Zheng); S. Bandinelli (Stefania); I.E. Barroso (Inês); P. Deloukas (Panagiotis); N.G. Forouhi (Nita); A. Hofman (Albert); Y. Liu (YongMei); L.-P. Lyytikäinen (Leo-Pekka); K.E. North (Kari); M. Dimitriou (Maria); G. Hallmans (Göran); M. Kähönen (Mika); C. Langenberg (Claudia); J.M. Ordovas (Jose); A.G. Uitterlinden (André); F.B. Hu (Frank); I.-P. Kalafati (Ioanna-Panagiota); O. Raitakari (Olli); O.H. Franco (Oscar); A. Johnson (Anthony); V. Emilsson (Valur); J.A. Schrack (Jennifer); R.D. Semba; D.S. Siscovick (David); D.K. Arnett (Donna); I.B. Borecki (Ingrid); P.W. Franks (Paul); S.B. Kritchevsky (Stephen); R.J.F. Loos (Ruth); M. Orho-Melander (Marju); J.I. Rotter (Jerome); N.J. Wareham (Nick); J.C.M. Witteman (Jacqueline); L. Ferrucci (Luigi); G.V. Dedoussis (George); L.A. Cupples (Adrienne); J.A. Nettleton (Jennifer )

    2013-01-01

    textabstractBackground: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake.

  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers

    NARCIS (Netherlands)

    Lauc, G.; Huffman, J.E.; Pucic, M.; Zgaga, L.; Adamczyk, B.; Muzinic, A.; Novokmet, M.; Polasek, O.; Gornik, O.; Kristic, J.; Keser, T.; Vitart, V.; Scheijen, B.; Uh, H.W.; Molokhia, M.; Patrick, A.L.; McKeigue, P.; Kolcic, I.; Lukic, I.K.; Swann, O.; Leeuwen, F.N. van; Ruhaak, L.R.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M.; Craen, A.J. de; Deelder, A.M.; Zeng, Q.; Wang, W.; Hastie, N.D.; Gyllensten, U.; Wilson, J.F.; Wuhrer, M.; Wright, A.F.; Rudd, P.M.; Hayward, C.; Aulchenko, Y.; Campbell, H.; Rudan, I.

    2013-01-01

    Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative

  6. Sex-stratified Genome-wide Association Studies Including 270000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    NARCIS (Netherlands)

    Randall, J.C.; Winkler, T.W.; Kutalik, Z.; Berndt, S.I.; Jackson, A.U.; Monda, K.L.; Kilpeläinen, T.O.; Esko, T.; Mägi, R.; Li, S.; Workalemahu, T.; Feitosa, M.F.; Croteau-Chonka, D.C.; Day, F.R.; Fall, T.; Ferreira, T.; Gustafsson, S.; Locke, A.E.; Mathieson, I.; Scherag, A.; Vedantam, S.; Wood, A.R.; Liang, L.; Steinthorsdottir, V.; Thorleifsson, G.; Dermitzakis, E.T.; Dimas, A.S.; Karpe, F.; Min, J.L.; Nicholson, G.; Clegg, D.J.; Person, T.; Krohn, J.P.; Bauer, S.; Buechler, C.; Eisinger, K.; Bonnefond, A.; Froguel, P.; Hottenga, J.J.; Prokopenko, I.; Waite, L.L.; Harris, T.B.; Smith, A.V.; Shuldiner, A.R.; McArdle, W.L.; Caulfield, M.J.; Munroe, P.B.; Grönberg, H.; Chen, Y.D.; Li, G.; Beckmann, J.S.; Johnson, T.; Thorsteinsdottir, U.; Teder-Laving, M.; Khaw, K.T.; Wareham, N.J.; Zhao, J.H.; Amin, N.; Oostra, B.A.; Kraja, A.T.; Province, M.A.; Cupples, L.A.; Heard-Costa, N.L.; Kaprio, J.; Ripatti, S.; Surakka, I.; Collins, F.S.; Saramies, J.; Tuomilehto, J.; Jula, A.; Salomaa, V.; Erdmann, J.; Hengstenberg, C.; Loley, C.; Schunkert, H.; Lamina, C.; Wichmann, H.E.; Albrecht, E.; Gieger, C.; Hicks, A.A.; Johansson, A.; Pramstaller, P.P.; Kathiresan, S.; Speliotes, E.K.; Penninx, B.W.J.H.; Hartikainen, A.L.; Järvelin, M.R.; Gyllensten, U.; Boomsma, D.I.; Campbell, H.; Wilson, J.F.; Chanock, S.J.; Farrall, M.; Goel, A.; Medina-Gomez, C.; Rivadeneira, F.; Estrada, K.; Uitterlinden, A.G.; Hofman, A.; Zillikens, M.C.; den Heijer, M.; Kiemeney, L.A.; Maschio, A.; Hall, P.; Tyrer, J.; Teumer, A.; Völzke, H.; Kovacs, P.; Tönjes, A.; Mangino, M.; Spector, T.D.; Hayward, C.; Rudan, I.; Hall, A.S.; Samani, N.J.; Attwood, A.P.; Sambrook, J.G.; Hung, J.; Palmer, L.J.; Lokki, M.L.; Sinisalo, J.; Boucher, G.; Huikuri, H.V.; Lorentzon, M.; Ohlsson, C.; Eklund, N.; Eriksson, J.G.; Barlassina, C.; Rivolta, C.; Nolte, I.M.; Snieder, H.; van der Klauw, M.M.; van Vliet-Ostaptchouk, J.V.; Gejman, P.V.; Shi, J.; Jacobs, K.B.; Wang, Z.; Bakker, S.J.; Mateo Leach, I.; Navis, G.; van der Harst, P.; Martin, N.G.; Medland, S.E.; Montgomery, G.W.; Yang, J.; Chasman, D.I.; Ridker, P.M.; Rose, L.M.; Lehtimäki, T.; Raitakari, O.; Absher, D.; Iribarren, C.; Basart, H.; Hovingh, K.G.; Hyppönen, E.; Power, C.; Anderson, D.; Beilby, J.P.; Hui, J.; Jolley, J.; Sager, H.; Bornstein, S.R.; Schwarz, P.E.; Kristiansson, K.; Perola, M.; Lindström, J.; Swift, A.J.; Uusitupa, M.; Atalay, M.; Lakka, T.A.; Rauramaa, R.; Bolton, J.L.; Fowkes, G.; Fraser, R.M.; Price, J.F.; Fischer, K.; Krjuta Kov, K.; Metspalu, A.; Mihailov, E.; Langenberg, C.; Luan, J.; Ong, K.K.; Chines, P.S.; Keinanen-Kiukaanniemie, S.; Saaristo, T.E.; Edkins, S.; Franks, P.W.; Hallmans, G.; Shungin, D.; Morris, A.D.; Palmer, C.N.A.; Erbel, R.; Moebus, S.; Nöthen, M.M.; Pechlivanis, S.; Hveem, K.; Narisu, N.; Hamsten, A.; Humphries, S.E.; Strawbridge, R.J.; Tremoli, E.; Grallert, H.; Thorand, B.; Illig, T.; Koenig, W.; Müller-Nurasyid, M.; Peters, A.; Boehm, B.O.; Kleber, M.E.; März, W.; Winkelmann, B.R.; Kuusisto, J.; Laakso, M.; Arveiler, D.; Cesana, G.; Kuulasmaa, K.; Virtamo, J.; Yarnell, J.W.; Kuh, D; Wong, A.; Lind, L.; de Faire, U.; Gigante, B.; Magnusson, P.K.E.; Pedersen, N.L.; Dedoussis, G.; Dimitriou, M.; Kolovou, G.; Kanoni, S.; Stirrups, K.; Bonnycastle, L.L.; Njolstad, I.; Wilsgaard, T.; Ganna, A.; Rehnberg, E.; Hingorani, A.D.; Kivimaki, M.; Kumari, M.; Assimes, T.L.; Barroso, I.; Boehnke, M.; Borecki, I.B.; Deloukas, P.; Fox, C.S.; Frayling, T.M.; Groop, L.C.; Haritunians, T.; Hunter, D.; Ingelsson, E.; Kaplan, R.; Mohlke, K.L.; O'Connell, J.R.; Schlessinger, D.; Strachan, D.P.; Stefansson, K.; van Duijn, C.M.; Abecasis, G.R.; McCarthy, M.I.; Hirschhorn, J.N.; Qi, L.; Loos, R.J.; Lindgren, C.M.; North, K.E.; Heid, I.M.

    2013-01-01

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723

  7. B→τν: Opening up the charged Higgs parameter space with R-parity violation

    International Nuclear Information System (INIS)

    Bose, Roshni; Kundu, Anirban

    2012-01-01

    The theoretically clean channel B + →τ + ν shows a close to 3σ discrepancy between the Standard Model prediction and the data. This in turn puts a strong constraint on the parameter space of a two-Higgs doublet model, including R-parity conserving supersymmetry. The constraint is so strong that it almost smells of fine-tuning. We show how the parameter space opens up with the introduction of suitable R-parity violating interactions, and release the tension between data and theory.

  8. Weight-4 Parity Checks on a Surface Code Sublattice with Superconducting Qubits

    Science.gov (United States)

    Takita, Maika; Corcoles, Antonio; Magesan, Easwar; Bronn, Nicholas; Hertzberg, Jared; Gambetta, Jay; Steffen, Matthias; Chow, Jerry

    We present a superconducting qubit quantum processor design amenable to the surface code architecture. In such architecture, parity checks on the data qubits, performed by measuring their X- and Z- syndrome qubits, constitute a critical aspect. Here we show fidelities and outcomes of X- and Z-parity measurements done on a syndrome qubit in a full plaquette consisting of one syndrome qubit coupled via bus resonators to four code qubits. Parities are measured after four code qubits are prepared into sixteen initial states in each basis. Results show strong dependence on ZZ between qubits on the same bus resonators. This work is supported by IARPA under Contract W911NF-10-1-0324.

  9. Bilateral femoral neck fractures resulting from pregnancy-associated osteoporosis showed bone marrow edema on magnetic resonance imaging.

    Science.gov (United States)

    Kasahara, Kyoko; Kita, Nobuyuki; Kawasaki, Taku; Morisaki, Shinsuke; Yomo, Hiroko; Murakami, Takashi

    2017-06-01

    Femoral neck fractures resulting from pregnancy-associated osteoporosis is a rare condition. Herein, we report an undoubted case of pregnancy-associated osteoporosis in a 38-year-old primiparous patient with pre-existing anorexia nervosa who suffered bilateral femoral neck fractures in the third trimester and early post-partum period. Magnetic resonance imaging revealed femoral neck fractures as well as diffuse marrow edema involving both femoral heads, which are considered under ordinary circumstances as characteristic imaging findings of transient osteoporosis of the hip. Based on our experience, we propose that pregnancy-associated osteoporosis might be present in femoral neck fractures attributed to transient osteoporosis of the hip in pregnancy. Conversely, bone status should be carefully and accurately estimated in cases of potential transient osteoporosis of the hip in pregnancy to reduce future fracture risk. © 2017 The Authors Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology.

  10. Parity Symmetry and Parity Breaking in the Quantum Rabi Model with Addition of Ising Interaction

    International Nuclear Information System (INIS)

    Wang Qiong; He Zhi; Yao Chun-Mei

    2015-01-01

    We explore the possibility to generate new parity symmetry in the quantum Rabi model after a bias is introduced. In contrast to a mathematical treatment in a previous publication [J. Phys. A 46 (2013) 265302], we consider a physically realistic method by involving an additional spin into the quantum Rabi model to couple with the original spin by an Ising interaction, and then the parity symmetry is broken as well as the scaling behavior of the ground state by introducing a bias. The rule can be found that the parity symmetry is broken by introducing a bias and then restored by adding new degrees of freedom. Experimental feasibility of realizing the models under discussion is investigated. (paper)

  11. Pax6 interacts with Iba1 and shows age-associated alterations in brain of aging mice.

    Science.gov (United States)

    Maurya, Shashank Kumar; Mishra, Rajnikant

    2017-07-01

    The Pax6, a transcriptional regulator and multifunctional protein, has been found critical for neurogenesis, neuro-degeneration, mental retardation, neuroendocrine tumors, glioblastoma and astrocytomas. The age-associated alteration in the expression of Pax6 in neuron and glia has also been observed in the immunologically privileged brain. Therefore, it is presumed that Pax6 may modulate brain immunity by activation of microglia either directly interacting with genes or proteins of microglia or indirectly though inflammation associated with neurodegeneration. This report describes evaluation of expression, co-localization and interactions of Pax6 with Ionized binding protein1 (Iba1) in brain of aging mice by Immunohistochemistry, Chromatin Immuno-precipitation (ChIP) and Co-immunoprecipitation (Co-IP), respectively. The co-localization of Pax6 with Iba1 was observed in the cerebellum, cerebral cortex, hippocampus, midbrain and olfactory lobe. The Pax6 and Iba1 also interact physically. The age-dependent alteration in their expression and co-localization were also observed in mice. Results indicate Pax6-dependent activities of Iba1 in the remodelling of microglia during immunological surveillance of the brain. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors.

    Science.gov (United States)

    Wang, Luqiao; Nanayakkara, Gayani; Yang, Qian; Tan, Hongmei; Drummer, Charles; Sun, Yu; Shao, Ying; Fu, Hangfei; Cueto, Ramon; Shan, Huimin; Bottiglieri, Teodoro; Li, Ya-Feng; Johnson, Candice; Yang, William Y; Yang, Fan; Xu, Yanjie; Xi, Hang; Liu, Weiqing; Yu, Jun; Choi, Eric T; Cheng, Xiaoshu; Wang, Hong; Yang, Xiaofeng

    2017-10-24

    Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in human tissues, (2) how the NR expression is modulated during atherosclerosis and metabolic diseases, and (3) the overview of the role of NRs in inflammatory conditions are not fully understood. To determine whether and how the expression of NRs are regulated in physiological/pathological conditions, we took an experimental database analysis to determine expression of all 48 known NRs in 21 human and 17 murine tissues as well as in pathological conditions. We made the following significant findings: (1) NRs are differentially expressed in tissues, which may be under regulation by oxygen sensors, angiogenesis pathway, stem cell master regulators, inflammasomes, and tissue hypo-/hypermethylation indexes; (2) NR sequence mutations are associated with increased risks for development of cancers and metabolic, cardiovascular, and autoimmune diseases; (3) NRs have less tendency to be upregulated than downregulated in cancers, and autoimmune and metabolic diseases, which may be regulated by inflammation pathways and mitochondrial energy enzymes; and (4) the innate immune sensor inflammasome/caspase-1 pathway regulates the expression of most NRs. Based on our findings, we propose a new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs). Our results have provided a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.

  13. Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2−/− Lung Fibroblasts

    Directory of Open Access Journals (Sweden)

    Mandar Dave

    2017-12-01

    Full Text Available The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung fibroblasts may display altered protein profiles which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor (MIF in lung fibroblasts derived from COX-2−/− but not wild-type (WT or COX-1−/− mice. MIF was spontaneously released in high levels into the extracellular milieu of COX2−/− fibroblasts seemingly from the preformed intracellular stores, with no change in the basal gene expression of MIF. The secretion and regulation of MIF in COX-2−/− was “prostaglandin-independent.” GO analysis showed that concurrent with upregulation of MIF, there is a significant surge in expression of genes related to fibroblast growth, FK506 binding proteins, and isomerase activity in COX-2−/− cells. Furthermore, COX-2−/− fibroblasts also exhibit a significant increase in transcriptional activity of various regulators, antagonists, and co-modulators of p53, as well as in the expression of oncogenes and related transcripts. Integrative Oncogenomics Cancer Browser (IntroGen analysis shows downregulation of COX-2 and amplification of MIF and/or p53 activity during development of glioblastomas, ependymoma, and colon adenomas. These data indicate the functional role of the MIF-COX-p53 axis in inflammation and cancer at the genomic and proteomic levels in COX-2-ablated cells. This systematic analysis not only shows the proinflammatory state but also unveils a molecular signature of a pro-oncogenic state of COX-1 in COX-2 ablated cells.

  14. Emergent odd-parity multipoles and magnetoelectric effects on a diamond structure: Implication for the 5 d transition metal oxides A OsO4 (A =K ,Rb, and Cs)

    Science.gov (United States)

    Hayami, Satoru; Kusunose, Hiroaki; Motome, Yukitoshi

    2018-01-01

    We report our theoretical predictions on the linear magnetoelectric (ME) effects originating from odd-parity multipoles associated with spontaneous spin and orbital ordering on a diamond structure. We derive a two-orbital model for d electrons in eg orbitals by including the effective spin-orbit coupling which arises from the mixing between eg and t2 g orbitals. We show that the model acquires a net antisymmetric spin-orbit coupling once staggered spin and orbital orders occur spontaneously. The staggered orders are accompanied by odd-parity multipoles: magnetic monopole, quadrupoles, and toroidal dipoles. We classify the types of the odd-parity multipoles according to the symmetry of the spin and orbital orders. Furthermore, by computing the ME tensor using the linear response theory, we show that the staggered orders induce a variety of the linear ME responses. We elaborate all possible ME responses for each staggered order, which are useful to identify the order parameter and to detect the odd-parity multipoles by measuring the ME effects. We also elucidate the effect of lowering symmetry by a tetragonal distortion, which leads to richer ME responses. The implications of our results are discussed for the 5 d transition metal oxides, A OsO4 (A =K,Rb, and Cs) , in which the order parameters are not fully identified.

  15. Parity violation in polarized electron scattering

    International Nuclear Information System (INIS)

    Prescott, C.Y.

    1980-10-01

    The weak forces are responsible for the decay of radioactive nuclei, and it was in these decay processes where parity non-conservation was first observed. Beta decay occurs through emission of e + or e - particles, indicating that the weak force can carry charge of both signs, and it was natural to speculate on the existence of a neutral component of the weak force. Even though weak neutral forces had not been observed it was conjectured that a neutral component of weak decay could exist, and Zel'dovich in 1957 suggested that parity violating effects may be observable in electron scattering and in atomic spectra. More than twenty years have passed since the early conjectures, and a great deal has been learned. Progress in quantum field theory led to the development of the SU(2) x U(1) gauge theory of weak and electromagnetic interactions and provided a renormalizable theory with a minimum of additional assumptions. Gauge theories predicted the existence of a new force, the neutral current interaction. This new interaction was first seen in 1973 in the Gargamelle bubble chamber at CERN. Today the neutral currents are accepted as well established, and it is the details of the neutral current structure that occupy attention. In particular the role that electrons play cannot be tested readily in neutrino beams (recent neutrino-electron scattering experiments are, however, rapidly improving this situation) and therefore interest in electron-hadron neutral current effects has been high. Parity violation is a unique signature of weak currents, and measurements of its size are a particularly important and sensitive means for determining the neutral current structure

  16. New parity, same old attitude towards psychotherapy?

    Science.gov (United States)

    Clemens, Norman A

    2010-03-01

    Full parity of health insurance benefits for treatment of mental illness, including substance use disorders, is a major achievement. However, the newly-published regulations implementing the legislation strongly endorse aggressive managed care as a way of containing costs for the new equality of coverage. Reductions in "very long episodes of out-patient care," hospitalization, and provider fees, along with increased utilization, are singled out as achievements of managed care. Medical appropriateness as defined by expert medical panels is to be the basis of authorizing care, though clinicians are familiar with a history of insurance companies' application of "medical necessity" to their own advantage. The regulations do not single out psychotherapy for attention, but long-term psychotherapy geared to the needs of each patient appears to be at risk. The author recommends that the mental health professions strongly advocate for the growing evidence base for psychotherapy including long-term therapy for complex mental disorders; respect for the structure and process of psychotherapy individualized to patients' needs; awareness of the costs of aggressive managed care in terms of money, time, administrative burden, and interference with the therapy; and recognition of the extensive training and experience required to provide psychotherapy as well as the stresses and demands of the work. Parity in out-of-network benefits could lead to aggressive management of care given by non-network practitioners. Since a large percentage of psychiatrists and other mental health professionals stay out of networks, implementation of parity for out-of-network providers will have to be done in a way that respects the conditions under which they would be willing and able to provide services, especially psychotherapy, to insured patients. The shortage of psychiatrists makes this an important access issue for the insured population in need of care.

  17. Efficient Instantiation of Parameterised Boolean Equation Systems to Parity Games

    Directory of Open Access Journals (Sweden)

    Gijs Kant

    2012-10-01

    Full Text Available Parameterised Boolean Equation Systems (PBESs are sequences of Boolean fixed point equations with data variables, used for, e.g., verification of modal mu-calculus formulae for process algebraic specifications with data. Solving a PBES is usually done by instantiation to a Parity Game and then solving the game. Practical game solvers exist, but the instantiation step is the bottleneck. We enhance the instantiation in two steps. First, we transform the PBES to a Parameterised Parity Game (PPG, a PBES with each equation either conjunctive or disjunctive. Then we use LTSmin, that offers transition caching, efficient storage of states and both distributed and symbolic state space generation, for generating the game graph. To that end we define a language module for LTSmin, consisting of an encoding of variables with parameters into state vectors, a grouped transition relation and a dependency matrix to indicate the dependencies between parts of the state vector and transition groups. Benchmarks on some large case studies, show that the method speeds up the instantiation significantly and decreases memory usage drastically.

  18. Parity and risk of diabetes in a Danish nationwide birth cohort

    DEFF Research Database (Denmark)

    Naver, K V; Lundbye-Christensen, S; Gorst-Rasmussen, A

    2011-01-01

    Aims The purpose was to elucidate the association between parity and the incidence of diabetes using national register data. Methods The study population consisted of all Danish women with a singleton delivery in 1982/1983 (n = 100 669), who subsequently had 74 966 deliveries. The included women ...

  19. Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation

    Directory of Open Access Journals (Sweden)

    Alexander Schütz

    2015-04-01

    Full Text Available Signal transducer and activator of transcription 3 (STAT3 is constitutively activated in the majority of lung cancer. This study aims at defining connections between STAT3 function and the malignant properties of non–small cell lung carcinoma (NSCLC cells. To address possible mechanisms by which STAT3 influences invasiveness, the expression of matrix metalloproteinase-1 (MMP-1 was analyzed and correlated with the STAT3 activity status. Studies on both surgical biopsies and on lung cancer cell lines revealed a coincidence of STAT3 activation and strong expression of MMP-1. MMP-1 and tyrosine-phosphorylated activated STAT3 were found co-localized in cancer tissues, most pronounced in tumor fronts, and in particular in adenocarcinomas. STAT3 activity was constitutive, although to different degrees, in the lung cancer cell lines investigated. Three cell lines (BEN, KNS62, and A549 were identified in which STAT3 activitation was inducible by Interleukin-6 (IL-6. In A549 cells, STAT3 activity enhanced the level of MMP-1 mRNA and stimulated transcription from the MMP-1 promoter in IL-6–stimulated A549 cells. STAT3 specificity of this effect was confirmed by STAT3 knockdown through RNA interference. Our results link aberrant activity of STAT3 in lung cancer cells to malignant tumor progression through up-regulation of expression of invasiveness-associated MMPs.

  20. MRI Shows that Exhaustion Syndrome Due to Chronic Occupational Stress is Associated with Partially Reversible Cerebral Changes.

    Science.gov (United States)

    Savic, I; Perski, A; Osika, W

    2018-03-01

    The present study investigates the cerebral effects of chronic occupational stress and its possible reversibility. Forty-eight patients with occupational exhaustion syndrome (29 women) and 80 controls (47 women) underwent structural magnetic resonance imaging (MRI) and neuropsychological testing. Forty-four participants (25 patients, 19 controls) also completed a second MRI scan after 1-2 years. Only patients received cognitive therapy. The stressed group at intake had reduced thickness in the right prefrontal cortex (PFC) and left superior temporal gyrus (STG), enlarged amygdala volumes, and reduced caudate volumes. Except for the caudate volume, these abnormalities were more pronounced in females. They were all related to perceived stress, which was similar for both genders. Thickness of the PFC also correlated with an impaired ability to down-modulate negative emotions. Thinning of PFC and reduction of caudate volume normalized in the follow-up. The amygdala enlargement and the left STG thinning remained. Longitudinal changes were not detected among controls. Chronic occupational stress was associated with partially reversible structural abnormalities in key regions for stress processing. These changes were dynamically correlated with the degree of perceived stress, highlighting a possible causal link. They seem more pronounced in women, and could be a substrate for an increased cerebral vulnerability to stress-related psychiatric disorders. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.

    Science.gov (United States)

    Greco, Rosaria; Siani, Francesca; Demartini, Chiara; Zanaboni, Annamaria; Nappi, Giuseppe; Davinelli, Sergio; Scapagnini, Giovanni; Tassorelli, Cristina

    2016-01-01

    Administration of nitroglycerin (NTG) to rats induces a hyperalgesic condition and neuronal activation of central structures involved in migraine pain. In order to identify therapeutic strategies for migraine pain, we evaluated the anti-nociceptive activity of Andrographis Paniculata (AP), a herbaceous plant, in the hyperalgesia induced by NTG administration in the formalin test. We also analyzed mRNA expression of cytokines in specific brain areas after AP treatment. Male Sprague-Dawley rats were pre-treated with AP extract 30 minutes before NTG or vehicle injection. The data show that AP extract significantly reduced NTG-induced hyperalgesia in phase II of the test, 4 hours after NTG injection. In addition, AP extract reduced IL-6 mRNA expression in the medulla and mesencephalon and also mRNA levels of TNFalpha in the mesencephalic region. These findings suggest that AP extract may be a potential therapeutic approach in the treatment of general pain, and possibly of migraine.

  2. Collider signals of gravitino dark matter in bilinearly broken R-parity

    International Nuclear Information System (INIS)

    Hirsch, M.; Porod, W.; Restrepo, D.

    2005-01-01

    In models with gauge mediated supersymmetry breaking the gravitino is the lightest supersymmetric particle. If R-parity is violated the gravitino decays, but with a half-live far exceeding the age of the universe and thus is, in principle, a candidate for the dark matter. We consider the decays of the next-to-lightest supersymmetric particle, assumed to be the neutralino. We show that in models where the breaking of R-parity is bilinear, the condition that R-parity violation explains correctly the measured neutrino masses fixes the branching ratio of the decay neutralino to gravitino gamma in the range (0.001-0.01), if the gravitino mass is in the range required to solve the dark matter problem, i.e. of the order (few) 100 eV. This scenario is therefore directly testable at the next generation of colliders. (author)

  3. Parity nonconservation in the hydrogen atom

    International Nuclear Information System (INIS)

    Chupp, T.E.

    1983-01-01

    The development of experiments to detect parity nonconserving (PNC) mixing of the 2s/sub a/2/ and 2p/sub 1/2/ levels of the hydrogen atom in a 570 Gauss magnetic field is described. The technique involves observation of an asymmetry in the rate of microwave induced transitions at 1608 MHz due to the interference of two amplitudes, one produced by applied microwave and static electric fields and the other produced by an applied microwave field and the 2s/sub 1/2/-2p/sub 1/2/ mixing inducd by a PNC Hamiltonian

  4. The parity doublet model with fluctuations

    Energy Technology Data Exchange (ETDEWEB)

    Weyrich, Johannes; Smekal, Lorenz von [TU Darmstadt (Germany); Strodthoff, Nils [Universitaet Heidelberg (Germany)

    2014-07-01

    In the 1970s the Walecka model and the chiral Walecka model were developed and have since been studied intensively. It was noted early on, however, that the chiral model leads to massless Lee-Wick nuclear matter in the chirally restored phase. A promising variant to describe nuclear matter and chiral symmetry restoration consistently is the parity doublet model (or mirror model). It has already been treated in a mean field (MF) approach with promising results. This is motivation for us to to examine this model with functional renormalization group (FRG) methods, hence including full mesonic fluctuations.

  5. Parity violating asymmetries in polarized electron scattering

    International Nuclear Information System (INIS)

    Derman, E.; Marciano, W.J.

    1979-01-01

    We discuss parity violating asymmetries between the scattering of right and left-handed electrons on a variety of targets. Implications for gauge theories from recent SLAC results on deep-inelastic electron-deuterium and electron-proton scattering are examined. A derivation of the asymmetry for electron-electron scattering is given, its advantages are pointed out, and the feasibility of such a measurement is discussed. Other proposed or contemplated asymmetry experiments are reviewed and the necessity of including the Collins-Wilczek-Zee hadronic axial isoscalar current contribution in asymmetry predictions is noted

  6. Parity violation experiments at intermediate energies

    International Nuclear Information System (INIS)

    Van Oers, W.T.H.

    1996-06-01

    The status of the TRIUMF 221 MeV proton-proton violation experiment is reviewed. Several other proton-proton parity violation experiments in the in the intermediate energy range, currently in various stages of preparation, are discussed. A new experiment at an energy of 5.13 GeV (and if confirmed also at an energy of tens of GeV) is needed to follow on the earlier unexpected large result obtained at 5.13 GeV. (author)

  7. A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer.

    Science.gov (United States)

    Troyer, Dean A; Jamaspishvili, Tamara; Wei, Wei; Feng, Ziding; Good, Jennifer; Hawley, Sarah; Fazli, Ladan; McKenney, Jesse K; Simko, Jeff; Hurtado-Coll, Antonio; Carroll, Peter R; Gleave, Martin; Lance, Raymond; Lin, Daniel W; Nelson, Peter S; Thompson, Ian M; True, Lawrence D; Brooks, James D; Squire, Jeremy A

    2015-08-01

    Loss of the phosphatase and tensin homolog (PTEN) tumor suppressor gene is a promising marker of aggressive prostate cancer. Active surveillance and watchful waiting are increasingly recommended to patients with small tumors felt to be low risk, highlighting the difficulties of Gleason scoring in this setting. There is an urgent need for predictive biomarkers that can be rapidly deployed to aid in clinical decision-making. Our objectives were to assess the incidence and ability of PTEN alterations to predict aggressive disease in a multicenter study. We used recently developed probes optimized for sensitivity and specificity in a four-color FISH deletion assay to study the Canary Retrospective multicenter Prostate Cancer Tissue Microarray (TMA). This TMA was constructed specifically for biomarker validation from radical prostatectomy specimens, and is accompanied by detailed clinical information with long-term follow-up. In 612 prostate cancers, the overall rate of PTEN deletion was 112 (18.3%). Hemizygous PTEN losses were present in 55/612 (9.0%) of cancers, whereas homozygous PTEN deletion was observed in 57/612 (9.3%) of tumors. Significant associations were found between PTEN status and pathologic stage (P free survival (number of events = 189), pre-operative prostate specific antigen (PSA) (P free survival in multivariate models, as were seminal vesicle invasion, extracapsular extension, and Gleason score, and preoperative PSA. Furthermore, these data demonstrate that the assay can be readily introduced at first diagnosis in a cost effective manner analogous to the use of FISH for analysis of HER2/neu status in breast cancer. Combined with published research beginning 17 years ago, both the data and tools now exist to implement a PTEN assay in the clinic. © 2015 The Authors. The Prostate, published by Wiley Periodicals, Inc.

  8. Proposed procedure for experimental determination of the spin-parity of the new particle X(3410)

    Energy Technology Data Exchange (ETDEWEB)

    Chao, P; Tseng, T; Chou, C

    1977-01-01

    A procedure is proposed for the experimental determination of the spin-parity of the new particle X(3410). It consists of choosing the events representing the radiative decay psi ..-->.. X(3410) + ..gamma.. from the psi-production experiment at ..sqrt..s = 6.84 GeV, and measuring the angular distribution of the ..gamma.. photon produced in the process, and also the energy distribution of two pseudo-scalar mesons from the subsequent decay of X. The result of calculation shows that the spin-parity of X(3410) can be determined with certainty and good sensitivity.

  9. Esthetics, eroticism and sex parity: Umberto Eco’s History of Beauty and History of Ugliness

    Directory of Open Access Journals (Sweden)

    Krzysztof Obremski

    2012-01-01

    Full Text Available The topic of comparative analysis which is presented in this article is The Story of Beauty and The Story of Ugliness edited by Umberto Eco. Even the covers of these books show the contrast between men and women. How esthetic values build a feedback with sexual parity? Ugly men look at beautiful women – this patriarchal discrimination can’t be cancelled either by the parity of sex in The Story of Beauty, nor men who twice outnumber them in The Story of Ugliness. Also as the unfair sex they are prior sex: they humiliate themselves and elevate women

  10. Even- and Odd-Parity Charmed Meson Masses in Heavy Hadron Chiral Perturbation Theory

    Energy Technology Data Exchange (ETDEWEB)

    Thomas Mehen; Roxanne Springer

    2005-03-01

    We derive mass formulae for the ground state, J{sup P} = 0{sup -} and 1{sup -}, and first excited even-parity, J{sup P} = 0{sup +} and 1{sup +}, charmed mesons including one loop chiral corrections and {Omicron}(1/m{sub c}) counterterms in heavy hadron chiral perturbation theory. We show a variety of fits to the current data. We find that certain parameter relations in the parity doubling model are not renormalized at one loop, providing a natural explanation for the equality of the hyperfine splittings of ground state and excited doublets.

  11. Psychosocial Stress and Preterm Birth: The Impact of Parity and Race.

    Science.gov (United States)

    Wheeler, Sarahn; Maxson, Pamela; Truong, Tracy; Swamy, Geeta

    2018-03-29

    Objectives Studies examining risk factors for preterm birth (PTB) such as psychosocial stress are often focused on women with a history of PTB; however, most preterm babies are born to women with no history of preterm birth. Our objective was to determine if the relationship between psychosocial stress and PTB is altered by parity. Non-Hispanic black (NHB) women have increased psychosocial stress and PTB; therefore, we further aimed to determine if race alters the relationship between psychosocial stress, parity, and PTB. Methods We performed a secondary analysis of the Healthy Pregnancy, Healthy Baby Study comparing pregnant women who were primiparous (first pregnancy), multiparous with history of preterm birth, or multiparous with history of term birth. Perceived stress, perceived racism, interpersonal support, John Henryism and self-efficacy were measured using validated instruments. Logistic regression was used to model the effect of psychosocial stress on PTB stratified by parity and race. Results The analysis entire cohort included 1606 subjects, 426 were primiparous, 268 had a history of presterm birth, and 912 had a history of term birth. In women with a history of term birth, higher self-efficacy was associated with lower odds of spontaneous PTB, and this association was amplified in NHB women. In women with a history of spontaneous PTB, John Henryism Active Coping was associated with lower odds of spontaneous PTB in the index pregnancy. Conclusions for Practice The relationship between psychosocial stress and PTB may be mediated by parity and race.

  12. 24-h urinary free cortisol from mid-pregnancy to 3-months postpartum: gender and parity differences and effects.

    Science.gov (United States)

    Conde, Ana; Figueiredo, Bárbara

    2014-12-01

    Pregnancy and postpartum have been associated to several physiological changes; however, empirical evidence was almost exclusively obtained in primiparous women and few studies focus on hormonal changes in men and second-time parents. The main aim of this study is to examine 24-h urinary free cortisol from mid-pregnancy to 3-months postpartum, comparing women/men and first/second-time parents. Twenty-six women and 22 men (N=48) were recruited from an antenatal obstetric unit in Porto, Portugal. 24-h urinary free cortisol was measured at the 2nd and 3rd trimester and at 3-months postpartum. Repeated measures analyses of variance were conducted, in order to analyze 24-h urinary free cortisol patterns of change over this period. Gender and parity were included in the analyses as potential modifiers, in order to compare women and men, and first- and second-time parents. An increase from the 2nd to the 3rd trimester (p=.006) and a decrease from the 3rd trimester to 3-months postpartum (p=.005) were reported in all parents' 24-h urinary free cortisol. The interaction effects for Time*Gender (p=.03) and Time*Parity (p=.02) were found. Women and first-time parents revealed higher levels, while men and second-time parents showed lower 24-h urinary free cortisol levels at the 2nd trimester than at 3-months postpartum. Findings appear to clarify the direction, as well as, the timing, gender and parity extension of 24-h urinary free cortisol changes from mid-pregnancy to 3-months postpartum. The same pattern of change in all parents' 24-h urinary free cortisol from mid-pregnancy to 3-months postpartum is consistent with the proposed role of hormones in preparation to parenting. Gender and parity differences and effects on 24-h urinary free cortisol are also consistent with cortisol as a stress biomarker for higher challenges associated to pregnancy and childbirth in women and first-time parents versus higher demands related to after childbirth parenting in men and second

  13. Algebraic renormalization of parity-preserving QED3 coupled to scalar matter II: broken case

    International Nuclear Information System (INIS)

    Cima, O.M. del; Franco, D.H.T.; Helayel-Neto, J.A.; Piguet, O.

    1996-11-01

    In this letter the algebraic renormalization method, which is independent of any kind of regularization scheme, is presented for the parity-preserving QED 3 coupled to scalar matter in the broken regime, where the scalar assumes a finite vacuum expectation value, =v. The model shows to be stable under radiative corrections and anomaly free. (author)

  14. Likelihood analysis of parity violation in the compound nucleus

    International Nuclear Information System (INIS)

    Bowman, D.; Sharapov, E.

    1993-01-01

    We discuss the determination of the root mean-squared matrix element of the parity-violating interaction between compound-nuclear states using likelihood analysis. We briefly review the relevant features of the statistical model of the compound nucleus and the formalism of likelihood analysis. We then discuss the application of likelihood analysis to data on panty-violating longitudinal asymmetries. The reliability of the extracted value of the matrix element and errors assigned to the matrix element is stressed. We treat the situations where the spins of the p-wave resonances are not known and known using experimental data and Monte Carlo techniques. We conclude that likelihood analysis provides a reliable way to determine M and its confidence interval. We briefly discuss some problems associated with the normalization of the likelihood function

  15. Low-energy restoration of parity and maximal symmetry

    International Nuclear Information System (INIS)

    Raychaudhuri, A.; Sarkar, U.

    1982-01-01

    The maximal symmetry of fermions of one generation, SU(16), which includes the left-right-symmetric Pati-Salam group, SU(4)/sub c/ x SU(2) /sub L/ x SU(2)/sub R/, as a subgroup, allows the possibility of a low-energy (M/sub R/approx.100 GeV) breaking of the left-right symmetry. It is known that such a low-energy restoration of parity can be consistent with weak-interaction phenomenology. We examine different chains of descent of SU(16) that admit a low value of M/sub R/ and determine the other intermediate symmetry-breaking mass scales associated with each of these chains. These additional mass scales provide an alternative to the ''great desert'' expected in some grand unifying models. The contributions of the Higgs fields in the renormalization-group equations are retained and are found to be important

  16. Even-parity quartet autodetaching states of He-

    International Nuclear Information System (INIS)

    Hazi, A.U.

    1981-01-01

    The total photodetachment cross section of the metastable, (1s2s2p) 4 P 0 state of He - has been recently measured at several wavelengths between 10 μ and 308 nm. As part of these calculations, the even parity, quartet, autodetaching states of He - which are optically connected to the metastable 4 P 0 state and which are associated with the n = 2 and n = 3 states of He were studied. In both the photodetachment and electron scattering calculations, extensive configuration interaction (CI) wavefunctions were used to describe the He target states, the He - resonance states and the photodetachment continua. The Stieltjes moment-theory technique was used to extract the partial photodetachment cross sections from the discrete representations of the electron scattering continua. The use of the Stieltjes technique allowed the inclusion of both channel-channel coupling and fully correlated He 3 S and 3 P 0 wavefunctions in the calculations. Results are presented and discussed

  17. Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume

    Directory of Open Access Journals (Sweden)

    Antonio B. Porcaro

    2016-01-01

    Conclusion: The investigation shows that TT relates to volume and grade of PCa; moreover, the density of TT relative to TV inversely associates with rate of increase of cancer that depends on the grade of the tumour.

  18. Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study.

    Science.gov (United States)

    Ishikuro, Mami; Obara, Taku; Metoki, Hirohito; Ohkubo, Takayoshi; Iwama, Noriyuki; Katagiri, Mikiko; Nishigori, Hidekazu; Narikawa, Yoko; Yagihashi, Katsuyo; Kikuya, Masahiro; Yaegashi, Nobuo; Hoshi, Kazuhiko; Suzuki, Masakuni; Kuriyama, Shinichi; Imai, Yutaka

    2015-11-01

    Parity has previously been reported to affect the difference in blood pressure (BP) measured in the office and at home, also known as the white-coat effect, during pregnancy. The objective of this study was to identify possible factors that cause the white-coat effect during pregnancy, focusing on parity. In total, 530 pregnant women (31.3±4.7 years old) who delivered at a maternal clinic were eligible for the study. The association between parity and the white-coat effect (clinic BP compared with home BP) was investigated for each trimester of pregnancy by multivariate analysis of covariance adjusted for age, body mass index, family history of hypertension and smoking habits. The magnitudes of the white-coat effect for systolic BP in the first, second and third trimesters were 4.1±9.8, 3.4±7.1 and 1.8±6.0 mm Hg, respectively and those for diastolic BP were 3.8±7.4, 1.6±5.8 and 2.4±4.9 mm Hg, respectively. Parity was significantly and negatively associated with the white-coat effect for systolic BP in the first trimester of pregnancy (nulliparous women: 5.07±0.61 mm Hg and multiparous women: 2.78±0.74 mm Hg, P=0.02) as well as for diastolic BP in the second and third trimesters of pregnancy. Age, body mass index, family history of hypertension and smoking were not significantly associated with the white-coat effect in any trimester of pregnancy. Parity may have an influence on the white-coat effect in pregnancy; however, the observed effect, on average 1-2 mm Hg, was small.

  19. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

    OpenAIRE

    Pooley, K. A.; Bojesen, S. E.; Weischer, M.; Nielsen, S. F.; Thompson, D.; Amin Al Olama, A.; Michailidou, K.; Tyrer, J. P.; Benlloch, S.; Brown, J.; Audley, T.; Luben, R.; Khaw, K.-T.; Neal, D. E.; Hamdy, F. C.

    2013-01-01

    Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the ?iCOGS? custom genotyping array. All ?200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL associatio...

  20. R-parity violating supersymmetry and neutrino physics: experimental signatures

    CERN Document Server

    Mitsou, Vasiliki A.

    2015-10-09

    $R$-parity violating supersymmetric models (RPV SUSY) are becoming increasingly more appealing than its $R$-parity conserving counterpart in view of the hitherto non-observation of SUSY signals at the LHC. In this paper, we discuss RPV scenarios where neutrino masses are naturally generated, namely RPV through bilinear terms (bRPV) and the $\\mu$-from-$\

  1. Separation of the 1+ /1- parity doublet in 20Ne

    Science.gov (United States)

    Beller, J.; Stumpf, C.; Scheck, M.; Pietralla, N.; Deleanu, D.; Filipescu, D. M.; Glodariu, T.; Haxton, W.; Idini, A.; Kelley, J. H.; Kwan, E.; Martinez-Pinedo, G.; Raut, R.; Romig, C.; Roth, R.; Rusev, G.; Savran, D.; Tonchev, A. P.; Tornow, W.; Wagner, J.; Weller, H. R.; Zamfir, N.-V.; Zweidinger, M.

    2015-02-01

    The (J , T) = (1 , 1) parity doublet in 20Ne at 11.26 MeV is a good candidate to study parity violation in nuclei. However, its energy splitting is known with insufficient accuracy for quantitative estimates of parity violating effects. To improve on this unsatisfactory situation, nuclear resonance fluorescence experiments using linearly and circularly polarized γ-ray beams were used to determine the energy difference of the parity doublet ΔE = E (1-) - E (1+) = - 3.2(± 0.7) stat(-1.2+0.6)sys keV and the ratio of their integrated cross sections Is,0(+) /Is,0(-) = 29(± 3) stat(-7+14)sys. Shell-model calculations predict a parity-violating matrix element having a value in the range 0.46-0.83 eV for the parity doublet. The small energy difference of the parity doublet makes 20Ne an excellent candidate to study parity violation in nuclear excitations.

  2. Effect of parity on endometrial glands in gravid rabbits | Pulei ...

    African Journals Online (AJOL)

    Effect of parity on endometrial glands in gravid rabbits. ... Anatomy Journal of Africa ... Image J. Endometrial gland density was noted to decrease with a rise in parity such that the percentage proportion in the primigravid rabbit was 45% compared to that of 34% and 37.5% in the biparous and multiparous groups respectively.

  3. Parity and isospin in pion condensation and tensor binding

    International Nuclear Information System (INIS)

    Pace, E.; Palumbo, F.

    1978-01-01

    In infinite nuclear matter with pion condensates or tensor binding both parity and isospin symmetries are broken. Finite nuclei with pion condensates or tensor binding, however, can have definite parity. They cannot have a definite value of isospin, whose average value is of the order of the number of nucleons. (Auth.)

  4. Evaluation of the influence of maternal parity on neonatal ...

    African Journals Online (AJOL)

    Maternal Parity has been shown to increase the risk of adverse neonatal outcomes, such as intrauterine growth restriction (IUGR), prematurity, and mortality. The study was designed to evaluate the influence of maternal parity on neonatal anthropometric parameters among Hausas in Kano. Five hundred and twenty one ...

  5. Parity violation in the nucleon-nucleon interaction

    International Nuclear Information System (INIS)

    Haxton, W.C.

    1989-01-01

    I discuss the present status of our understanding of parity nonconservation (PNC) in the nucleon-nucleon interaction, and some of the difficulties inherent in nuclear tests of PNC. I also discuss the nucleon/nuclear anapole moment, the parity violating coupling of the photon, and its relation to the PNC NN interaction. 13 refs., 1 fig., 2 tabs

  6. Possible Odd Parity State in 128Xe

    International Nuclear Information System (INIS)

    Broman, L.; Malmskog, S.G.

    1966-07-01

    Gamma lines in the decay of I have been measured by means of a Ge(Li) detector. The following gamma ray energies have been obtained: 442.5 ± 0.05, 526.5 ± 0.5, 742.4 ±1.0, 969.0 ± 1.0, and 1136.5 ±2.0 keV. The 1136.5 keV transition defines a level in 128 Xe at 1579 ± 2 keV. From the log ft = 7.8 ± 0.3 of the (β - feeding, this level is believed to have an odd parity. Upper limits of gamma ray intensities for transitions around eV are used to set a limit for the population of the expected 0 + level originating from the two-phonon quadrupole vibration

  7. Parity doublers in chiral potential quark models

    International Nuclear Information System (INIS)

    Kalashnikova, Yu. S.; Nefediev, A. V.; Ribeiro, J. E. F. T.

    2007-01-01

    The effect of spontaneous breaking of chiral symmetry over the spectrum of highly excited hadrons is addressed in the framework of a microscopic chiral potential quark model (Generalised Nambu-Jona-Lasinio model) with a vectorial instantaneous quark kernel of a generic form. A heavy-light quark-antiquark bound system is considered, as an example, and the Lorentz nature of the effective light-quark potential is identified to be a pure Lorentz-scalar, for low-lying states in the spectrum, and to become a pure spatial Lorentz vector, for highly excited states. Consequently, the splitting between the partners in chiral doublets is demonstrated to decrease fast in the upper part of the spectrum so that neighboring states of an opposite parity become almost degenerate. A detailed microscopic picture of such a 'chiral symmetry restoration' in the spectrum of highly excited hadrons is drawn and the corresponding scale of restoration is estimated

  8. Constraints of a Parity-Conserving Interaction

    Science.gov (United States)

    van Oers, Willem T. H.

    2002-09-01

    Time-Reversal-Invariance non-conservation has for the first time been unequivocally demonstrated in a direct measurement at CPLEAR. One then can ask the question: What about tests of time-reversal-invariance in systems other than the kaon system? Tests of time-reversal-invariance can be distinguished as belonging to two classes: the first one deals with time-reversal-invariance-non-conserving (T-odd)/parity violating (P-odd) interactions, while the second one deals with T-odd/P-even interactions (assuming CPT conservation this implies C-conjugation non-conservation). Limits on a T-odd/P-odd interaction follow from measurements of the electric dipole moment of the neutron (room for further experimentation?

  9. Statistical mechanics of low-density parity-check codes

    Energy Technology Data Exchange (ETDEWEB)

    Kabashima, Yoshiyuki [Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama 2268502 (Japan); Saad, David [Neural Computing Research Group, Aston University, Birmingham B4 7ET (United Kingdom)

    2004-02-13

    We review recent theoretical progress on the statistical mechanics of error correcting codes, focusing on low-density parity-check (LDPC) codes in general, and on Gallager and MacKay-Neal codes in particular. By exploiting the relation between LDPC codes and Ising spin systems with multi-spin interactions, one can carry out a statistical mechanics based analysis that determines the practical and theoretical limitations of various code constructions, corresponding to dynamical and thermodynamical transitions, respectively, as well as the behaviour of error-exponents averaged over the corresponding code ensemble as a function of channel noise. We also contrast the results obtained using methods of statistical mechanics with those derived in the information theory literature, and show how these methods can be generalized to include other channel types and related communication problems. (topical review)

  10. TIME HORIZON AND UNCOVERED INTEREST PARITY IN EMERGING ECONOMIES

    Directory of Open Access Journals (Sweden)

    Norlida Hanim Mohd Salleh

    2011-07-01

    Full Text Available The aim of this study is to re-examine the well-known empirical puzzle of uncovered interest parity (UIP for emerging market economies with different prediction time horizons. The empirical results obtained using dynamic panel and time series techniques for monthly data from January 1995 to December 2009 eventually show that the panel data estimates are more powerful than those obtained by applying individual time series estimations and the significant contribution of the exchange rate prediction horizons in determining the status of UIP. This finding reveals that at the longer time horizon, the model has better econometric specification and thus more predictive power for exchange rate movements compared to the shorter time period. The findings can also be a signalling of well-integrated currency markets and a reliable guide to international investors as well as for the orderly conduct of monetary authorities.

  11. Littlest Higgs with T-parity. Status and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Reuter, Juergen; Tonini, Marco; Vries, Maikel de

    2013-11-15

    The Littlest Higgs model with T-parity is providing an attractive solution to the fine-tuning problem. This solution is only entirely natural if its intrinsic symmetry breaking scale f is relatively close to the electroweak scale. We examine the constraints using the latest results from the 8 TeV run at the LHC. Both direct searches and Higgs precision physics are taken into account. The constraints from Higgs couplings are by now competing with electroweak precision tests and both combined exclude f up to 694 GeV. At the same time limits from direct searches now become competitive and constrain f to be larger than 638 GeV. We show that the Littlest Higgs model parameter space is slowly driven into the TeV range. Furthermore, we develop a strategy on how to optimise present supersymmetry searches for the considered model, with the goal to improve the constraints and yield more stringent limits on f.

  12. Statistical mechanics of low-density parity-check codes

    International Nuclear Information System (INIS)

    Kabashima, Yoshiyuki; Saad, David

    2004-01-01

    We review recent theoretical progress on the statistical mechanics of error correcting codes, focusing on low-density parity-check (LDPC) codes in general, and on Gallager and MacKay-Neal codes in particular. By exploiting the relation between LDPC codes and Ising spin systems with multi-spin interactions, one can carry out a statistical mechanics based analysis that determines the practical and theoretical limitations of various code constructions, corresponding to dynamical and thermodynamical transitions, respectively, as well as the behaviour of error-exponents averaged over the corresponding code ensemble as a function of channel noise. We also contrast the results obtained using methods of statistical mechanics with those derived in the information theory literature, and show how these methods can be generalized to include other channel types and related communication problems. (topical review)

  13. Conference on photovoltaic energy network parity

    International Nuclear Information System (INIS)

    Abadie, Pierre-Marie; Masson, Gaetan; Henzelmann, Orsten; Joly, Jean-Pierre; Guillemoles, Jean-Francois; Auffret, Jean-Marc; Berger, Arnaud; Binder, Jann; Martin, David; Beck, Bernhard; Mahuet, Audrey; Mueller, Thorsten; Contamin, Raphael

    2012-01-01

    The French-German office for Renewable energies (OFAEnR) organised a conference on the present day and future challenges of the development, support and market integration of photovoltaic energy. In the framework of this French-German exchange of experience, about 120 participants exchanged views on support models to renewable energy sources, research results on self-consumption and business models for the renewable energies sector. This document brings together the available presentations (slides) made during this event: 1 - Overview of France's PV support policies (Pierre-Marie Abadie); 2 - Grid parity: first step towards PV competitiveness (Gaetan Masson); 3 - How competitive is solar power? Requirements and impact on the European industry (Orsten Henzelmann); 4 - Key elements of the National Institute of Solar energy - INeS (Jean-Pierre Joly); 5 - Research priorities according to the Paris Institute of Photovoltaics (Jean-Francois Guillemoles); 6 - Bosch Solar energy (Jean-Marc Auffret); 7 - Financing and insuring photovoltaics - History and future prospects (Arnaud Berger); 8 - Decentralized Photovoltaics: Autonomy, Self-Consumption and Reduction of Grid Loading through electrical and Thermal Storage (Jann Binder); 9 - Off Grid systems, mini grid and grid parity, field feedback and perspectives. From the producer-consumer to the smart grid: experience feedback of PV management models (David Martin); 10 - Benefits for solar power plants in respect of grid stabilization (Bernhard Beck); 11 - Renewable energies integration to electricity market: impacts and challenges (Audrey Mahuet); 12 - Promotion of PV in Germany: Feed-in tariffs, self-consumption and direct selling - Review and forecast (Thorsten Mueller); 13 - How to support renewable electricity in France? (Raphael Contamin)

  14. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

    Science.gov (United States)

    Pooley, Karen A.; Bojesen, Stig E.; Weischer, Maren; Nielsen, Sune F.; Thompson, Deborah; Amin Al Olama, Ali; Michailidou, Kyriaki; Tyrer, Jonathan P.; Benlloch, Sara; Brown, Judith; Audley, Tina; Luben, Robert; Khaw, K-T; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Kote-Jarai, Zsofia; Baynes, Caroline; Shah, Mitul; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dicks, Ed; Yang, Rongxi; Rudolph, Anja; Schildkraut, Joellen; Chang-Claude, Jenny; Burwinkel, Barbara; Chenevix-Trench, Georgia; Pharoah, Paul D. P.; Berchuck, Andrew; Eeles, Rosalind A.; Easton, Douglas F.; Dunning, Alison M.; Nordestgaard, Børge G.

    2013-01-01

    Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the “iCOGS” custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10−10) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10−7) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10−14) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10−4) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks. PMID:23900074

  15. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.

    Science.gov (United States)

    Pooley, Karen A; Bojesen, Stig E; Weischer, Maren; Nielsen, Sune F; Thompson, Deborah; Amin Al Olama, Ali; Michailidou, Kyriaki; Tyrer, Jonathan P; Benlloch, Sara; Brown, Judith; Audley, Tina; Luben, Robert; Khaw, K-T; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Kote-Jarai, Zsofia; Baynes, Caroline; Shah, Mitul; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Yang, Rongxi; Rudolph, Anja; Schildkraut, Joellen; Chang-Claude, Jenny; Burwinkel, Barbara; Chenevix-Trench, Georgia; Pharoah, Paul D P; Berchuck, Andrew; Eeles, Rosalind A; Easton, Douglas F; Dunning, Alison M; Nordestgaard, Børge G

    2013-12-15

    Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10(-10)) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10(-7)) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10(-14)) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10(-4)) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks.

  16. Effect of calving interval and parity on milk yield per feeding day in Danish commercial dairy herds.

    Science.gov (United States)

    Lehmann, J O; Fadel, J G; Mogensen, L; Kristensen, T; Gaillard, C; Kebreab, E

    2016-01-01

    The idea of managing cows for extended lactations rather than lactations of the traditional length of 1 yr primarily arose from observations of increasing problems with infertility and cows being dried off with high milk yields. However, it is vital for the success of extended lactation practices that cows are able to maintain milk yield per feeding day when the length of the calving interval (CInt) is increased. Milk yield per feeding day is defined as the cumulated lactation milk yield divided by the sum of days between 2 consecutive calvings. The main objective of this study was to investigate the milk production of cows managed for lactations of different lengths, and the primary aim was to investigate the relationship between CInt, parity, and milk yield. Five measurements of milk yield were used: energy-corrected milk (ECM) yield per feeding day, ECM yield per lactating day, cumulative ECM yield during the first 305 d of lactation, as well as ECM yield per day during early and late lactation. The analyses were based on a total of 1,379 completed lactations from cows calving between January 2007 and May 2013 in 4 Danish commercial dairy herds managed for extended lactation for several years. Herd-average CInt length ranged from 414 to 521 d. The herds had Holstein, Jersey, or crosses between Holstein, Jersey, and Red Danish cows with average milk yields ranging from 7,644 to 11,286 kg of ECM per cow per year. A significant effect of the CInt was noted on all 5 measurements of milk yield, and this effect interacted with parity for ECM per feeding day, ECM per lactating day and ECM per day during late lactation. The results showed that cows were at least able to produce equivalent ECM per feeding day with increasing CInt, and that first- and second-parity cows maintained ECM per lactating day. Cows with a CInt between 17 and 19 mo produced 476 kg of ECM more during the first 305 d compared with cows with a CInt of less than 13 mo. Furthermore, early

  17. Does having children extend life span? A genealogical study of parity and longevity in the Amish.

    Science.gov (United States)

    McArdle, Patrick F; Pollin, Toni I; O'Connell, Jeffrey R; Sorkin, John D; Agarwala, Richa; Schäffer, Alejandro A; Streeten, Elizabeth A; King, Terri M; Shuldiner, Alan R; Mitchell, Braxton D

    2006-02-01

    The relationship between parity and life span is uncertain, with evidence of both positive and negative relationships being reported previously. We evaluated this issue by using genealogical data from an Old Order Amish community in Lancaster, Pennsylvania, a population characterized by large nuclear families, homogeneous lifestyle, and extensive genealogical records. The analysis was restricted to the set of 2,015 individuals who had children, were born between 1749 and 1912, and survived until at least age 50 years. Pedigree structures and birth and death dates were extracted from Amish genealogies, and the relationship between parity and longevity was examined using a variance component framework. Life span of fathers increased in linear fashion with increasing number of children (0.23 years per additional child; p =.01), while life span of mothers increased linearly up to 14 children (0.32 years per additional child; p =.004) but decreased with each additional child beyond 14 (p =.0004). Among women, but not men, a later age at last birth was associated with longer life span (p =.001). Adjusting for age at last birth obliterated the correlation between maternal life span and number of children, except among mothers with ultrahigh (>14 children) parity. We conclude that high parity among men and later menopause among women may be markers for increased life span. Understanding the biological and/or social factors mediating these relationships may provide insights into mechanisms underlying successful aging.

  18. Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

    DEFF Research Database (Denmark)

    Gustavsen, Marte W; Viken, Marte K; Celius, Elisabeth G

    2014-01-01

    Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the associ......Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated...

  19. International parity relations between Poland and Germany: a cointegrated VAR approach

    OpenAIRE

    Stazka, Agnieszka

    2008-01-01

    This paper analyses empirically the purchasing power parity, the uncovered interest parity and the real interest parity (Fisher parity) between Poland and Germany. The international parity relations are investigated jointly within the cointegrated VAR framework. Our analysis fails to find evidence that the parities, or any linear combinations of them, hold for our data set. We identify two long-run equilibrium relations: one imposing a long-run homogeneity restriction on the domestic (i.e. Po...

  20. Against Strong Ethical Parity: Situated Cognition Theses and Transcranial Brain Stimulation.

    Science.gov (United States)

    Heinrichs, Jan-Hendrik

    2017-01-01

    According to a prominent suggestion in the ethics of transcranial neurostimulation the effects of such devices can be treated as ethically on par with established, pre-neurotechnological alterations of the mind. This parity allegedly is supported by situated cognition theories showing how external devices can be part of a cognitive system. This article will evaluate this suggestion. It will reject the claim, that situated cognition theories support ethical parity. It will however point out another reason, why external carriers or modifications of the mental might come to be considered ethically on par with internal carriers. Section "Why Could There Be Ethical Parity between Neural Tissue and External Tools?" presents the ethical parity theses between external and internal carriers of the mind as well as neurotechnological alterations and established alterations. Section "Extended, Embodied, Embedded: Situated Cognition as a Relational Thesis" will elaborate the different situated cognition approaches and their relevance for ethics. It will evaluate, whether transcranial stimulation technologies are plausible candidates for situated cognition theses. Section "On the Ethical Relevance of Situated Cognition Theses" will discuss criteria for evaluating whether a cognitive tool is deeply embedded with a cognitive system and apply these criteria to transcranial brain stimulation technologies. Finally it will discuss the role diverse versions of situated cognition theory can play in the ethics of altering mental states, especially the ethics of transcranial brain stimulation technologies.

  1. Testing gravitational parity violation with coincident gravitational waves and short gamma-ray bursts

    International Nuclear Information System (INIS)

    Yunes, Nicolas; O'Shaughnessy, Richard; Owen, Benjamin J.; Alexander, Stephon

    2010-01-01

    Gravitational parity violation is a possibility motivated by particle physics, string theory, and loop quantum gravity. One effect of it is amplitude birefringence of gravitational waves, whereby left and right circularly polarized waves propagate at the same speed but with different amplitude evolution. Here we propose a test of this effect through coincident observations of gravitational waves and short gamma-ray bursts from binary mergers involving neutron stars. Such gravitational waves are highly left or right circularly polarized due to the geometry of the merger. Using localization information from the gamma-ray burst, ground-based gravitational wave detectors can measure the distance to the source with reasonable accuracy. An electromagnetic determination of the redshift from an afterglow or host galaxy yields an independent measure of this distance. Gravitational parity violation would manifest itself as a discrepancy between these two distance measurements. We exemplify such a test by considering one specific effective theory that leads to such gravitational parity violation, Chern-Simons gravity. We show that the advanced LIGO-Virgo network and all-sky gamma-ray telescopes can be sensitive to the propagating sector of Chern-Simons gravitational parity violation to a level roughly 2 orders of magnitude better than current stationary constraints from the LAGEOS satellites.

  2. Coffee Index as Quick and Simple Indicator of Purchasing Power Parity

    Directory of Open Access Journals (Sweden)

    Jakub Fischer

    2018-03-01

    Full Text Available Purchasing Power Parity is the corner stone of all international comparisons. Various approaches to Purchasing Power Parity, such as the Big Mac Index, KFC Index, iPad Index, Tall Latte Index or Ikea Index were popularized to the broader audience besides the OECD Purchasing Power Parity indices. The aim of this paper is to develop a new ready-to-use quick and simple index based on the prices of Nespresso coffee’s capsules and show the main challenges of such indices as well as of the PPP concept. For the purpose of our research the data on the Nespresso capsules prices were collected. Taking into account also the popularity (demand side of the capsules types, the Espresso line was chosen as the basis for which all further calculations are made. The Nespresso Index provides us with clear evidence that the Law of One Price cannot work in recent world because of three key features. Firstly, differences in taxes make the perfect parity impossible. Secondly, the price discrimination prevents the rational subjects from arbitrage. Finally, the changes in the exchange rate make such indices highly volatile. Despite these weaknesses, the Nespresso Index could be used as the useful supplement of the OECD PPP as it is low cost, easy and fast to compute and digestible for the lay public.

  3. Medium effects and parity doubling of hyperons across the deconfinement phase transition

    Science.gov (United States)

    Aarts, Gert; Allton, Chris; Boni, Davide De; Hands, Simon; Jäger, Benjamin; Praki, Chrisanthi; Skullerud, Jon-Ivar

    2018-03-01

    We analyse the behaviour of hyperons with strangeness S = -1,-2,-3 in the hadronic and quark gluon plasma phases, with particular interest in parity doubling and its emergence as the temperature grows. This study uses our FASTSUM anisotropic Nf = 2+1 ensembles, with four temperatures below and four above the deconfinement transition temperature, Tc. The positive-parity groundstate masses are found to be largely temperature independent below Tc, whereas the negative-parity ones decrease considerably as the temperature increases. Close to the transition, the masses are almost degenerate, in line with the expectation from chiral symmetry restoration. This may be of interest for heavy-ion phenomenology. In particular we show an application of this effect to the Hadron Resonance Gas model. A clear signal of parity doubling is found above Tc in all hyperon channels, with the strength of the effect depending on the number of s-quarks in the baryons. Presented at 35th International Symposium on Lattice Field Theory, 18-24 June 2017, Granada, Spain

  4. Cohort fertility decline in low fertility countries: Decomposition using parity progression ratios

    Directory of Open Access Journals (Sweden)

    Krystof Zeman

    2018-02-01

    Full Text Available Background: The long-term decline in cohort fertility in highly developed countries has been widely documented. However, no systematic analysis has investigated which parity contributed most to the fertility decline to low and very low levels. Objective: We examine how the contribution of changing parity progression ratios varied across cohorts, countries, and broader regions in Europe, North America, Australia, and East Asia. We pay special attention to countries that reached very low completed cohort fertility, below 1.75 children per woman. Methods: Using population censuses and large-scale surveys for 32 low fertility countries, we decompose the change in completed cohort fertility among women born between 1940 and 1970. The decomposition method takes into account the sequential nature of childbearing as a chain of transitions from lower to higher parities. Results: Among women born between 1940 and 1955, the fertility decline was mostly driven by reductions in the progression ratios to third and higher-order births. By contrast, among women born between 1955 and 1970, changes in fertility showed distinct regional patterns: in Central and Eastern Europe they were fuelled by falling second-birth rates, whereas in the German-speaking countries, Southern Europe, and East Asia decreases in first-birth rates played the major role. Conclusions: Pathways to low and very low fertility show distinct geographical patterns, which reflect the diversity of the cultural, socioeconomic, and institutional settings of low fertility countries. Contribution: Our study highlights the importance of analysing parity-specific components of fertility in order to understand fertility change and variation. We demonstrate that similar low levels of completed cohort fertility can result from different combinations of parity-specific fertility rates.

  5. Dairy shows different associations with abdominal and BMI-defined overweight: Cross-sectional analyses exploring a variety of dairy products.

    Science.gov (United States)

    Brouwer-Brolsma, E M; Sluik, D; Singh-Povel, C M; Feskens, E J M

    2018-05-01

    Previous studies have suggested weight-regulatory properties for several dairy nutrients, but population-based studies on dairy and body weight are inconclusive. We explored cross-sectional associations between dairy consumption and indicators of overweight. We included 114,682 Dutch adults, aged ≥18 years. Dairy consumption was quantified by a food frequency questionnaire. Abdominal overweight was defined as waist circumference (WC) ≥88 cm (women) or ≥102 cm (men) (n = 37,391), overweight as BMI ≥25-30 kg/m 2 (n = 44,772) and obesity as BMI ≥30 kg/m 2 (n = 15,339). Associations were quantified by logistic (abdominal overweight, no/yes), multinomial logistic (BMI-defined overweight and obesity) and linear regression analyses (continuous measures of WC and BMI), and they were adjusted for relevant covariates. Total dairy showed a positive association with abdominal overweight (OR Q1 ref vs. Q5: 1.09; 95% CI: 1.04-1.14) and with BMI-defined overweight (OR Q5 1.13; 95% CI: 1.08-1.18) and obesity (OR Q5 1.09; 95% CI: 1.02-1.16). Skimmed, semi-skimmed and non-fermented dairy also showed positive associations with overweight categories. Full-fat dairy showed an inverse association with overweight and obesity (OR Q5 for obesity: 0.78; 95% CI: 0.73-0.83). Moreover, inverse associations were observed for yoghurt and custard and positive associations for milk, buttermilk, flavoured yoghurt drinks, cheese and cheese snacks. Fermented dairy, curd cheese and Dutch cheese did not show a consistent association with overweight categories. Total, skimmed, semi-skimmed and non-fermented dairy; milk; buttermilk; flavoured yoghurt drinks; total cheese and cheese snacks showed a positive association with overweight categories, whereas full-fat dairy, custard and yoghurt showed an inverse association with overweight categories. Copyright © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human

  6. Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren

    DEFF Research Database (Denmark)

    Lauritzen, Lotte; Sorensen, Louise B.; Harslof, Laurine B.

    2017-01-01

    , and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P ≤ 0.002), and minor...... alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). We identified sex interactions in 50% of the SNP performance sets. Sex-dependent associations were observed for rs174448 and rs1535 on the d2 Test of Attention outcomes (P ... reading scores and rs174448 and rs2397142 (P sex-specific analyses showed associations in opposite directions in girls and boys. The minor allele carriage of rs174448 was associated with lower d2 Test of Attention performance (P

  7. Aperture Mask for Unambiguous Parity Determination in Long Wavelength Imagers

    Science.gov (United States)

    Bos, Brent

    2011-01-01

    A document discusses a new parity pupil mask design that allows users to unambiguously determine the image space coordinate system of all the James Webb Space Telescope (JWST) science instruments by using two out-of-focus images. This is an improvement over existing mask designs that could not completely eliminate the coordinate system parity ambiguity at a wavelength of 5.6 microns. To mitigate the problem of how the presence of diffraction artifacts can obscure the pupil mask detail, this innovation has been created with specifically designed edge features so that the image space coordinate system parity can be determined in the presence of diffraction, even at long wavelengths.

  8. A new source for parity violating nuclear force

    International Nuclear Information System (INIS)

    Iqbal, M.J.; Niskanen, J.A.

    1989-02-01

    We propose a mechanism for parity violation in the two nucleon meson-exchange interaction by way of the mixing of mesons of opposite parities. This mixing arises from parity violating W ± and Z exchange between the q-antiq pari in the meson. Numerically is effect turns out to be as important as vector meson exchange with a weak meson-nucleon vertex. The calculation is performed using both the standard Born approximation adding the amplitude phases by Watson's theorem and also using the exact correlated two-nucleon wave functions. The effect of correlations and form factors is found to be crucially important at intermediate energies

  9. Parity and time invariance violation in mercury

    International Nuclear Information System (INIS)

    Ginges, J.S.M.; Dzuba, V.A.; Flambaum, V.V.; Kozlov, M.G.

    2002-01-01

    Full text: In a recent experiment, a stringent upper limit was placed on the atomic electric dipole moment (EDM) of 199 Hg corresponding to the best limit on an atomic EDM to date. This limit can be interpreted in terms of a limit on a parity-and time-invariance violating (P,T-odd) nuclear electric moment, the Schiff moment. This moment can arise in the nucleus due to an intrinsic EDM of an unpaired nucleon or a P,T-odd interaction between nucleons. In previous calculations the electrostatic potential of the Schiff moment was expressed in a singular form which must be treated carefully to avoid divergences in the electronic matrix elements. We have shown that the electric field distribution inside the nucleus arising from the Schiff moment is constant and directed along the nuclear spin. This allows us to express the Schiff moment in a form more convenient for numerical relativistic atomic calculations. We have calculated the atomic EDM induced in Hg due to the Schiff moment (for which no direct calculation has previously been performed) and have placed new limits on the fundamental P,T-odd parameters. These limits strongly constrain competing theories of CP-violation

  10. Education Attainment and Parity Explain the Relationship Between Maternal Age and Breastfeeding Duration in U.S. Mothers.

    Science.gov (United States)

    Whipps, Mackenzie D M

    2017-02-01

    Prior research in high-income countries finds that young mothers tend to breastfeed their infants for shorter durations than older mothers; however, there are gaps in our understanding of the processes by which age influences breastfeeding. Research aim: The primary objective of this study was to test the mediating effects of parity and education attainment on the association between maternal age and two breastfeeding outcomes: total duration and duration of exclusive breastfeeding. This study was a secondary data analysis of the IFPS II, a prospective, longitudinal study of ~ 4,900 American mothers. Robust and bias-corrected regression analyses tested the direct effect of age and the indirect effects of age through parity and education for each outcome of interest. Parity and education attainment together explain nearly all of the association between maternal age and both measures of breastfeeding duration. The mediating role of education is significantly larger than parity for both outcomes. These findings indicate that maternal age primarily indexes parity and education but contributes minimally to breastfeeding duration via a direct effect. The findings have implications for intervention development and targeting strategies.

  11. Quantitative microbial risk assessment (QMRA) shows increased public health risk associated with exposure to river water under conditions of riverbed sediment resuspension

    CSIR Research Space (South Africa)

    Abia

    2016-10-01

    Full Text Available of The Total Environment, 556-557, pp 1143-1151 Quantitative microbial risk assessment (QMRA) shows increased public health risk associated with exposure to river water under conditions of riverbed sediment resuspension Akebe Luther King Abia a...

  12. Son Preference and Family Limitation in Pakistan: A Parity- and Contraceptive Method-Specific Analysis.

    Science.gov (United States)

    Channon, Melanie Dawn

    2017-09-01

    Son preference exerts a strong influence over contraceptive and fertility decisions in many South Asian countries. In Pakistan, where fertility remains high and contraceptive use low, research on son preference has been limited. Data from Pakistan Demographic and Health Surveys conducted in 1990-1991, 2006-2007 and 2012-2013 were used to examine potential indicators and outcomes of son preference. Descriptive analyses looked at sex composition preferences of men and women, as well as the sex ratio at last birth. Multivariate logistic regression analyses examined parity progression by birth order, while multinomial logistic regression was used to identify associations between sex composition and use of permanent, temporary and traditional contraceptive methods. Parity progression and choice of contraceptive method are increasingly associated with the sex composition of children. Many respondents wanted at least two sons, though most also wanted at least one daughter. Analyses suggest that the prevalence of modern contraceptive use among parous women would have been 19% higher in 2012-2013 in the absence of son preference. Permanent method use was extremely low among women with no sons and increased significantly with number of sons. The association between number of sons and use of temporary methods was weaker, while son preference had little relationship with traditional method use. The association of son preference with parity progression and modern contraceptive use has become stronger in Pakistan. Continuation of the fertility transition may be difficult unless the degrees of differential stopping behavior and differential contraceptive use decline.

  13. Analysis tools for discovering strong parity violation at hadron colliders

    International Nuclear Information System (INIS)

    Backovic, Mihailo; Ralston, John P.

    2011-01-01

    Several arguments suggest parity violation may be observable in high energy strong interactions. We introduce new analysis tools to describe the azimuthal dependence of multiparticle distributions, or 'azimuthal flow'. Analysis uses the representations of the orthogonal group O(2) and dihedral groups D N necessary to define parity completely in two dimensions. Classification finds that collective angles used in event-by-event statistics represent inequivalent tensor observables that cannot generally be represented by a single 'reaction plane'. Many new parity-violating observables exist that have never been measured, while many parity-conserving observables formerly lumped together are now distinguished. We use the concept of 'event-shape sorting' to suggest separating right- and left-handed events, and we discuss the effects of transverse and longitudinal spin. The analysis tools are statistically robust, and can be applied equally to low or high multiplicity events at the Tevatron, RHIC or RHIC Spin, and the LHC.

  14. Some simple criteria for gauged R-parity

    Energy Technology Data Exchange (ETDEWEB)

    Martin, S.P.

    1992-07-01

    Some simple conditions which are sufficient to guarantee that R- parity survives as an unbroken gauged discrete subgroup of the continuous gauge symmetry in certain supersymmetric extensions of the standard model are presented.

  15. Study of positive parity bands in 137Pr

    International Nuclear Information System (INIS)

    Agarwal, Priyanka; Kumar, Suresh; Jain, A.K.; Singh, Sukhjeet; Malik, S.S.; Sinha, Rishi Kumar; Dhal, Anukul; Chaturvedi, L.; Muralithar, S.; Singh, R.P.; Madhavan, N.; Kumar, Rakesh; Bhowmik, R.K.; Pancholi, S.C.; Jain, H.C.

    2006-01-01

    In this paper the analysis and interpretation of the positive parity states in 137 Pr have been reported. The detailed interpretation with configuration assignments and the calculations for the bands will be reported

  16. Noise-tolerant parity learning with one quantum bit

    Science.gov (United States)

    Park, Daniel K.; Rhee, June-Koo K.; Lee, Soonchil

    2018-03-01

    Demonstrating quantum advantage with less powerful but more realistic devices is of great importance in modern quantum information science. Recently, a significant quantum speedup was achieved in the problem of learning a hidden parity function with noise. However, if all data qubits at the query output are completely depolarized, the algorithm fails. In this work, we present a quantum parity learning algorithm that exhibits quantum advantage as long as one qubit is provided with nonzero polarization in each query. In this scenario, the quantum parity learning naturally becomes deterministic quantum computation with one qubit. Then the hidden parity function can be revealed by performing a set of operations that can be interpreted as measuring nonlocal observables on the auxiliary result qubit having nonzero polarization and each data qubit. We also discuss the source of the quantum advantage in our algorithm from the resource-theoretic point of view.

  17. On the static Casimir effect with parity-breaking mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Fosco, C.D. [Comision Nacional de Energia Atomica, Centro Atomico Bariloche and Instituto Balseiro, Bariloche (Argentina); Remaggi, M.L. [Universidad Nacional de Cuyo, Facultad de Ciencias Exactas y Naturales, Mendoza (Argentina)

    2017-03-15

    We study the Casimir interaction energy due to the vacuum fluctuations of the electromagnetic (EM) field in the presence of two mirrors, described by 2+1-dimensional, generally nonlocal actions, which may contain both parity-conserving and parity-breaking terms. We compare the results with the ones corresponding to Chern-Simons boundary conditions and evaluate the interaction energy for several particular situations. (orig.)

  18. Gender parity in Senegal – A continuing struggle

    OpenAIRE

    Tøraasen, Marianne

    2017-01-01

    In 2010, the Senegalese women’s movement, supported by political elites and international norms, managed to push for the adoption of one of the world’s most radical gender quota laws to date. This was achieved without the support of the powerful religious leaders, the marabouts. However, the marabouts fought back in the 2014 local elections and thwarted the full implementation of parity. This CMI Insight explores the on-going fight for parity in Senegal.

  19. Parity nonconservation in polarized electron scattering at high energies

    International Nuclear Information System (INIS)

    Prescott, C.Y.

    1979-10-01

    Recent observations of parity violation in inelastic scattering of electrons at high energy is discussed with reference to the process e(polarized) + D(unpolarized) → e + X. The kinetics of this process, the idealized case of scattering from free quark targets, experimental techniques and results, and relations to atomic physics of parity violation in bismuth and thallium atoms with a model independent analysis. 17 references

  20. Experimental search for parity nonconservation in atomic thallium

    International Nuclear Information System (INIS)

    Commins, E.D.

    1978-01-01

    In the lecture an experimental search for parity nonconservation in the 6 2 P/sub 1/2/--7 2 P/sub 1/2/ transition in atomic thallium is described. The reason for the choice of this particular transition, a description of the method, the results to data, and a brief description of the future plans are given. The very preliminary results suggest that the Weinberg--Salam model correctly describes parity nonconservation effects in atoms. 5 references

  1. Parity- and time-reversal-violating moments of light nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Vries, Jordy de, E-mail: devries@kvi.nl [KVI, theory group (Netherlands)

    2013-03-15

    I present the calculation of parity- and time-reversal-violating moments of the nucleon and light nuclei, originating from the QCD {theta}-bar term and effective dimension-six operators. By applying chiral effective field theory these calculations are performed in a unified framework. I argue that measurements of a few light-nuclear electric dipole moments would shed light on the mechanism of parity and time-reversal violation.

  2. Constraints on a Parity-Conserving Interaction

    Science.gov (United States)

    van Oers, Willem T. H.

    Time-reversal-invariance non-conservation has for the first time been unequivocally demonstrated in a direct measurement at CPLEAR. One then can ask the question: What about tests of time-reversal-invariance in systems other than the kaon system? Tests of time-reversal-invariance can be distinguished as belonging to two classes: the first one deals with parity violating (P-odd)/time-reversal-invariance-odd (T-odd) interactions, while the second one deals with P-even/T-odd interactions (assuming CPT conservation this implies C-conjugation non-conservation). Limits on a P-odd/T-odd interaction follow from measurements of the electric dipole moment of the neutron (with a present upper limit of 6 × 10-26 e.cm [95% C.L.]). It provides a limit on a P-odd/T-odd pion-nucleon coupling constant which is less than 10-4 times the weak interaction strength. Experimental limits on a P-even/T-odd interaction are much less stringent. Following the standard approach of describing the nucleon-nucleon interaction in terms of meson exchanges it can be shown that only charged rho-meson exchange and A1-meson exchange can lead to a P-even/T-odd interaction. The better constraints stem from measurements of the electric dipole moment of the neutron and from measurements of charge-symmetry breaking in neutron-proton elastic scattering. The latter experiments were executed at TRIUMF (497 and 347 MeV) and at IUCF (183 MeV). Weak decay experiments may provide limits which will possibly be comparable. All other experiments, like gamma decay experiments, detailed balance experiments, polarization-analyzing power difference determinations, and five-fold correlation experiments with polarized incident nucleons and aligned nuclear targets, have been shown to be at least an order of magnitude less sensitive. The question then emerges: is there room for further experimentation?

  3. Is rooftop solar PV at socket parity without subsidies?

    International Nuclear Information System (INIS)

    Hagerman, Shelly; Jaramillo, Paulina; Morgan, M. Granger

    2016-01-01

    Installations of rooftop solar photovoltaic (PV) technology in the United States have increased dramatically in recent years, in large part because of state and federal subsidies. In the future, such subsidies may be reduced or eliminated. From the homeowner's perspective, solar PV is competitive when it can produce electricity at a cost equivalent to the retail electricity rate, a condition sometimes referred to as “socket parity”. In assessing the economic viability of residential solar PV, most existing literature considers only a few locations and fails to consider the differences in PV system cost and electricity prices that exist across the U.S. We combined insolation data from more than 1000 locations, installation costs by region, and county-level utility rates to provide a more complete economic assessment of rooftop solar PV across the U.S. We calculated the break-even electricity prices and evaluated the reductions in installed costs needed to reach socket parity. Among the scenarios considered, we estimate that only Hawaii has achieved socket parity without the use of subsidies. With subsidies, six states reach socket parity, yet widespread parity is still not achieved. We find that high installation costs and financing rates are two of the largest barriers to socket parity. - Highlights: • We evaluate the economic viability of residential rooftop solar PV across the U.S. • Widespread socket parity has not been achieved in the U.S. without subsidies. • Net metering may be critical for the economic viability of rooftop solar PV.

  4. The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery.

    Science.gov (United States)

    MacLennan, A H; Taylor, A W; Wilson, D H; Wilson, D

    2000-12-01

    To define the prevalence of pelvic floor disorders in a non-institutionalised community and to determine the relationship to gender, age, parity and mode of delivery. A representative population survey using the 1998 South Australian Health Omnibus Survey. Random selection of 4400 households; 3010 interviews were conducted in the respondents' homes by trained female interviewers. This cross sectional survey included men and women aged 15-97 years. The prevalence of all types of self-reported urinary incontinence in men was 4.4% and in women was 35.3% (Pparity and age. The highest prevalence (51.9%) was reported in women aged 70-74 years. The prevalence of flatus and faecal incontinence was 6.8% and 2.3% in men and 10.9% and 3.5% in women, respectively. Pregnancy (> 20 weeks), regardless of the mode of delivery, greatly increased the prevalence of major pelvic floor dysfunction, defined as any type of incontinence, symptoms of prolapse or previous pelvic floor surgery. Multivariate logistic regression showed that, compared with nulliparity, pelvic floor dysfunction was significantly associated with caesarean section (OR 2.5, 95% CI 1.5-4.3), spontaneous vaginal delivery (OR 3.4, 95% CI 2.4-4.9) and at least one instrumental delivery (OR 4.3, 95% CI 2.8-6.6). The difference between caesarean and instrumental delivery was significant (Pparity and were reported in 19.9% of men and 30.2% of women. Pelvic floor disorders are very common and are strongly associated with female gender, ageing, pregnancy, parity and instrumental delivery. Caesarean delivery is not associated with a significant reduction in long term pelvic floor morbidity compared with spontaneous vaginal delivery.

  5. On spontaneous parity breaking in three-dimensional gauge-Higgs systems

    International Nuclear Information System (INIS)

    Ambjoern, J.; Farakos, K.; Shaposhnikov, M.E.

    1991-04-01

    We address the question of spontaneous breaking of parity in three-dimensional euclidian SU(2) gauge-Higgs theory by Monte Carlo simulations. We observe no sign of spontaneous parity breaking in the behaviour of local gauge invariant operators. However, the presence of parity odd terms in the action can induce a phase transition to a parity odd ground state. (orig.)

  6. Colostrum immunoglobulin G concentration of multiparous Jersey cows at first and second milking is associated with parity, colostrum yield, and time of first milking, and can be estimated with Brix refractometry.

    Science.gov (United States)

    Silva-Del-Río, N; Rolle, D; García-Muñoz, A; Rodríguez-Jiménez, S; Valldecabres, A; Lago, A; Pandey, P

    2017-07-01

    The objective of this study was to evaluate colostrum IgG concentration harvested at first and second milking from multiparous Jersey cows, the dam's lactation number, colostrum yield, and time of first milking. In addition, we validated the use of a Brix refractometer to estimate IgG concentration in colostrum from multiparous Jersey cows using radial immunodiffusion as the reference method. Colostrum samples and total weight of colostrum harvested at first (n = 134) and second (n = 68) milking were collected from 134 multiparous Jersey cows housed in a California herd. Fresh colostrum samples were analyzed for IgG concentration with Brix refractometry and frozen samples by radial immunodiffusion. A total of 90.4 and 42.7% of the samples from first and second milking met industry standards of quality for IgG concentration (>50 g/L). Second and third lactation cows had similar colostrum IgG concentration but lower than cows on their fourth and greater lactation. At second milking, 56.4% of cows on their fourth or greater lactation had colostrum IgG concentrations >50 g/L. When colostrum yield increased from low (6 kg), IgG concentration decreased. Higher IgG concentration was observed on colostrum harvested at 50 IgG g/L was 20.9% based on logit equations with Youden's index criterion and 18.0% based on accuracy criterion. For colostrum harvested at second milking, similar Brix thresholds were obtained, 19.2 and 19.0%, regardless of whether Youden's index or accuracy was used as the selection criterion. Our results indicate that the dam's lactation number, colostrum yield, and time of first milking relative to calving are associated with IgG concentration in colostrum from multiparous Jersey cows. Second milking colostrum from mature Jersey cows should be evaluated to extend colostrum supply on dairies especially during times of shortage. Readings of %Brix can be used to rapidly estimate IgG concentration in Jersey colostrum harvested at first and second milking

  7. Parity generator and parity checker in the modified trinary number system using savart plate and spatial light modulator

    Science.gov (United States)

    Ghosh, Amal K.

    2010-09-01

    The parity generators and the checkers are the most important circuits in communication systems. With the development of multi-valued logic (MVL), the proposed system with parity generators and checkers is the most required using the recently developed optoelectronic technology in the modified trinary number (MTN) system. This system also meets up the tremendous needs of speeds by exploiting the savart plates and spatial light modulators (SLM) in the optical tree architecture (OTA).

  8. Universal Greenberger-Horne-Zeilinger-state analyzer based on two-photon polarization parity detection

    International Nuclear Information System (INIS)

    Qian Jun; Feng Xunli; Gong Shangqing

    2005-01-01

    We present a universal analyzer for the three-particle Greenberger-Horne-Zeilinger (GHZ) states with quantum nondemolition parity detectors and linear-optics elements. In our scheme, all of the three-photon GHZ states can be discriminated with nearly unity probability in the regime of weak nonlinearity feasible at the present state of the art experimentally. We also show that our scheme can be easily extended to the analysis of the multi-particle GHZ states

  9. Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Minxue Shen

    Full Text Available It has been reported that higher folate intake from food and supplementation is associated with decreased blood pressure (BP. The association between serum folate concentration and BP has been examined in few studies. We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women.We used the baseline data from a pre-conception cohort of women of childbearing age in Liuyang, China, for this study. Demographic data were collected by structured interview. Serum folate concentration was measured by immunoassay, and homocysteine, blood glucose, triglyceride and total cholesterol were measured through standardized clinical procedures. Multiple linear regression and principal component regression model were applied in the analysis.A total of 1,532 healthy normotensive non-pregnant women were included in the final analysis. The mean concentration of serum folate was 7.5 ± 5.4 nmol/L and 55% of the women presented with folate deficiency (< 6.8 nmol/L. Multiple linear regression and principal component regression showed that serum folate levels were inversely associated with systolic and diastolic BP, after adjusting for demographic, anthropometric, and biochemical factors.Serum folate is inversely associated with BP in non-pregnant women of childbearing age with high prevalence of folate deficiency.

  10. Recent Measurements from the G0 Parity Violation Experiment Carried out at Jefferson Laboratory

    International Nuclear Information System (INIS)

    Bimbot, L.

    2008-01-01

    The measurements were made at the Thomas Jefferson National Accelerator Facility (J Lab.), Newport News, V A (USA) in the backward angle configuration set-up. A toroidal spectrometer, associated with particle detectors, is used to count electrons and pions from a liquid hydrogen or deuterium target. Parity-violating than the former one by orders of magnitude and requires special techniques to be observed and isolated. Parity violation is specific to the electro-weak interaction and forms the basis asymmetries in elastic electron-proton scattering are determined for momentum transfers of Q 2 = 0.62 and 0.23 (GeV/c) 2 . Combined with previous results obtained with the forward angle configuration setup, these measurements give access to the separation of the values of electric and magnetic strange form factors of the proton. More results may be extracted from the asymmetries for inelastically scattered electrons and for produced pions

  11. Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

    Science.gov (United States)

    Adoue, Véronique; Michailidou, Kyriaki; Canisius, Sander; Lemaçon, Audrey; Droit, Arnaud; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Baynes, Caroline; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Darabi, Hatef; Dennis, Joe; Devilee, Peter; Dörk, Thilo; Dos-Santos-Silva, Isabel; Eriksson, Mikael; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; García-Closas, Montserrat; Giles, Graham G.; Goldberg, Mark S.; González-Neira, Anna; Grenaker-Alnæs, Grethe; Guénel, Pascal; Haeberle, Lothar; Haiman, Christopher A.; Hamann, Ute; Hallberg, Emily; Hooning, Maartje J.; Hopper, John L.; Jakubowska, Anna; Jones, Michael; Kabisch, Maria; Kataja, Vesa; Lambrechts, Diether; Marchand, Loic Le; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Maranian, Mel; Margolin, Sara; Marme, Frederik; Milne, Roger L.; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Olswold, Curtis; Peto, Julian; Plaseska-Karanfilska, Dijana; Pylkäs, Katri; Radice, Paolo; Rudolph, Anja; Sawyer, Elinor J.; Schmidt, Marjanka K.; Shu, Xiao-Ou; Southey, Melissa C.; Swerdlow, Anthony; Tollenaar, Rob A.E.M.; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Vachon, Celine; Van Den Ouweland, Ans M. W.; Wang, Qin; Winqvist, Robert; Investigators, kConFab/AOCS; Zheng, Wei; Benitez, Javier; Chenevix-Trench, Georgia; Dunning, Alison M.; Pharoah, Paul D. P.; Kristensen, Vessela; Hall, Per; Easton, Douglas F.; Pastinen, Tomi; Nord, Silje; Simard, Jacques

    2016-01-01

    There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with differential allelic expression are functional candidates for further investigation as disease-causing variants. To investigate whether common variants associated with differential allelic expression were involved in breast cancer susceptibility, a list of genes was established on the basis of their involvement in cancer related pathways and/or mechanisms. Thereafter, using data from a genome-wide map of allelic expression associated SNPs, 313 genetic variants were selected and their association with breast cancer risk was then evaluated in 46,451 breast cancer cases and 42,599 controls of European ancestry ascertained from 41 studies participating in the Breast Cancer Association Consortium. The associations were evaluated with overall breast cancer risk and with estrogen receptor negative and positive disease. One novel breast cancer susceptibility locus on 4q21 (rs11099601) was identified (OR = 1.05, P = 5.6x10-6). rs11099601 lies in a 135 kb linkage disequilibrium block containing several genes, including, HELQ, encoding the protein HEL308 a DNA dependant ATPase and DNA Helicase involved in DNA repair, MRPS18C encoding the Mitochondrial Ribosomal Protein S18C and FAM175A (ABRAXAS), encoding a BRCA1 BRCT domain-interacting protein involved in DNA damage response and double-strand break (DSB) repair. Expression QTL analysis in breast cancer tissue showed rs11099601 to be associated with HELQ (P = 8.28x10-14), MRPS18C (P = 1.94x10-27) and FAM175A (P = 3.83x10-3), explaining about 20%, 14% and 1%, respectively of the variance inexpression of these genes in breast carcinomas. PMID:27792995

  12. Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.

    Science.gov (United States)

    Hamdi, Yosr; Soucy, Penny; Adoue, Véronique; Michailidou, Kyriaki; Canisius, Sander; Lemaçon, Audrey; Droit, Arnaud; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Baynes, Caroline; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brand, Judith S; Brauch, Hiltrud; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Chang-Claude, Jenny; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Darabi, Hatef; Dennis, Joe; Devilee, Peter; Dörk, Thilo; Dos-Santos-Silva, Isabel; Eriksson, Mikael; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; García-Closas, Montserrat; Giles, Graham G; Goldberg, Mark S; González-Neira, Anna; Grenaker-Alnæs, Grethe; Guénel, Pascal; Haeberle, Lothar; Haiman, Christopher A; Hamann, Ute; Hallberg, Emily; Hooning, Maartje J; Hopper, John L; Jakubowska, Anna; Jones, Michael; Kabisch, Maria; Kataja, Vesa; Lambrechts, Diether; Le Marchand, Loic; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Maranian, Mel; Margolin, Sara; Marme, Frederik; Milne, Roger L; Neuhausen, Susan L; Nevanlinna, Heli; Neven, Patrick; Olswold, Curtis; Peto, Julian; Plaseska-Karanfilska, Dijana; Pylkäs, Katri; Radice, Paolo; Rudolph, Anja; Sawyer, Elinor J; Schmidt, Marjanka K; Shu, Xiao-Ou; Southey, Melissa C; Swerdlow, Anthony; Tollenaar, Rob A E M; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Vachon, Celine; Van Den Ouweland, Ans M W; Wang, Qin; Winqvist, Robert; Zheng, Wei; Benitez, Javier; Chenevix-Trench, Georgia; Dunning, Alison M; Pharoah, Paul D P; Kristensen, Vessela; Hall, Per; Easton, Douglas F; Pastinen, Tomi; Nord, Silje; Simard, Jacques

    2016-12-06

    There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with differential allelic expression are functional candidates for further investigation as disease-causing variants. To investigate whether common variants associated with differential allelic expression were involved in breast cancer susceptibility, a list of genes was established on the basis of their involvement in cancer related pathways and/or mechanisms. Thereafter, using data from a genome-wide map of allelic expression associated SNPs, 313 genetic variants were selected and their association with breast cancer risk was then evaluated in 46,451 breast cancer cases and 42,599 controls of European ancestry ascertained from 41 studies participating in the Breast Cancer Association Consortium. The associations were evaluated with overall breast cancer risk and with estrogen receptor negative and positive disease. One novel breast cancer susceptibility locus on 4q21 (rs11099601) was identified (OR = 1.05, P = 5.6x10-6). rs11099601 lies in a 135 kb linkage disequilibrium block containing several genes, including, HELQ, encoding the protein HEL308 a DNA dependant ATPase and DNA Helicase involved in DNA repair, MRPS18C encoding the Mitochondrial Ribosomal Protein S18C and FAM175A (ABRAXAS), encoding a BRCA1 BRCT domain-interacting protein involved in DNA damage response and double-strand break (DSB) repair. Expression QTL analysis in breast cancer tissue showed rs11099601 to be associated with HELQ (P = 8.28x10-14), MRPS18C (P = 1.94x10-27) and FAM175A (P = 3.83x10-3), explaining about 20%, 14% and 1%, respectively of the variance inexpression of these genes in breast carcinomas.

  13. Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD.

    Science.gov (United States)

    Bralten, Janita; Franke, Barbara; Waldman, Irwin; Rommelse, Nanda; Hartman, Catharina; Asherson, Philip; Banaschewski, Tobias; Ebstein, Richard P; Gill, Michael; Miranda, Ana; Oades, Robert D; Roeyers, Herbert; Rothenberger, Aribert; Sergeant, Joseph A; Oosterlaan, Jaap; Sonuga-Barke, Edmund; Steinhausen, Hans-Christoph; Faraone, Stephen V; Buitelaar, Jan K; Arias-Vásquez, Alejandro

    2013-11-01

    Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms ((p)empirical = .007) but not with inattentive symptoms ((p)empirical = .73). Analysis of parent-rated Conners hyperactive/impulsive symptom scores validated this result ((p)empirical = .0018). Teacher-rated Conners scores were not associated. Post hoc analyses showed a significant contribution of all pathways to the hyperactive/impulsive symptom domain (dopamine/norepinephrine, (p)empirical = .0004; serotonin, (p)empirical = .0149; neuritic outgrowth, (p)empirical = .0452). The present analysis shows an association between common variants in 3 genetic pathways and the hyperactive/impulsive component of ADHD. This study demonstrates that pathway-based association analyses, using quantitative measurements of ADHD symptom domains, can increase the power of genetic analyses to

  14. Ab initio calculation of molecular energies including parity violating interactions

    International Nuclear Information System (INIS)

    Bakasov, A.; Ha Taekyu; Quack, M.

    1995-01-01

    A new approach, RHF-CIS, based on the perturbation of the ground state RHF wave function by the CIS excitations, has been implemented for evaluation of energy of parity violating interaction in molecules, E pv . The earlier approach, RHF-SDE, was based on the perturbation of the RHF ground states by the single-determinant ''excitations'' (SDE). The results obtained show the dramatic difference between E pv values in the RHF-CIS framework and those in the RHF-SDE framework: the E pv values of the RHF-CIS formalism are more than one order of magnitude greater compared to the RHF-SDE formalism as well as the corresponding tensor components. The maximal total value obtained for hydrogen peroxide in the RHF-CIS framework is 3.661 X 10 -19 E H (DZ ** basis set) while the maximal E pv value for the RHF-SDE formalism is just 3.635 X 10 -20 E H (TZ basis set). It is remarkable that both in the RFH-CIS and in the RHF-SDE approaches the diagonal tensor components of E pv strictly follow the geometry of a molecule and are always different from zero at chiral conformations. The zeros of the total E pv at chiral geometries are now found to be the results of the interplay between the diagonal tensor components values. We have carried out exhaustive analysis of the RHF-SDE formalism and found that it is not sufficiently accurate for studies of E pv . To this end, we have completely reproduced the previous work, which has been done in the RHF-SDE frame-work, and developed it further, studying how the RHF-SDE results vary when changing size and quality of basis sets. This last resource does not save the RHF-SDE formalism for evaluations of E pv from the general failure. Packages of FORTRAN routines called ENWEAK/RHFSDE-93 and ENWEAK/RHFCIS-94 have been developed which run on top of an ab initio MO package. We used 6-31G and 6-31G**, DZ and DZ**, TZ and TZ**, and (10s, 6p,**) basis sets. We will discuss the importance of the present results for possible measurement of the parity

  15. Effect of parity on healthy promotion lifestyle behavior in women.

    Science.gov (United States)

    Nazik, Hakan; Nazik, Evşen; Özdemir, Funda; Gül, Şule; Tezel, Ayfer; Narin, Raziye

    2015-01-01

    Health-promoting lifestyle behaviors are not only for the prevention of a disease or discomfort, but are also behaviors that aim to improve the individual's general health and well-being. Nurses have an important position in the development of healthy lifestyle behaviors in women. The aim of this study was to assess the effect of parity on health-promoting lifestyle behaviors in women. This descriptive and cross-sectional survey was performed in Adana, Turkey. This study was conducted with 352 women. The questionnaire consisted of two parts; the first part consisted of questions that assessed the socio-demographic and obstetric characteristics, and the second part employed the "Health Promotion Lifestyle Profile Scale" (HPLP). Data analysis included percentage, arithmetic average, and ANOVA tests. The results revealed that 24.1% of the women had no parity, 13.6% had one parity, 30.7% had two parities, 14.6% had three parities, and 17% had four and above parities. The mean total HPLP was 126.66±18.12 (interpersonal support subscale, 24.46±4.02; nutrition subscale, 21.59±3.92; self-actualization subscale, 24.42±4.30; stress management subscale, 18.73±3.81; health responsibility subscale, 21.75±4.31; and exercise subscale, 15.71±4.22). The health behavior of women was moderate. A statistically significant correlation was found between the number of parities and the Health Responsibility, Nutrition, Interpersonal Support, which is the subscale of the HPLP Scale.

  16. Results on Parity-Check Matrices With Optimal Stopping And/Or Dead-End Set Enumerators

    NARCIS (Netherlands)

    Weber, J.H.; Abdel-Ghaffar, K.A.S.

    2008-01-01

    The performance of iterative decoding techniques for linear block codes correcting erasures depends very much on the sizes of the stopping sets associated with the underlying Tanner graph, or, equivalently, the parity-check matrix representing the code. In this correspondence, we introduce the

  17. Motor Skills and Free-Living Physical Activity Showed No Association Among Preschoolers in 2012 U.S. National Youth Fitness Survey.

    Science.gov (United States)

    Loprinzi, Paul D; Frith, Emily

    2017-04-01

    Albeit limited, some emerging work, using convenience-based samples, has demonstrated that greater motor skill development is associated with higher physical activity among preschool-aged children. The purpose of this study was to evaluate this topic using data from the 2012 National Youth Fitness Survey that included 329 preschool-aged children (3-5 years). Parents proxy-reported their child's physical activity, with motor skill level assessed from the Test of Gross Motor Development-Second Edition (TGMD2). Motor skill levels (Gross Motor Quotient, locomotor or object control) were not associated with preschool free-living physical activity in any analytic model. Thus, in this large sample of preschoolers, contrary to research with older children, motor skill level was not associated with physical activity. Findings are discussed in terms of study limitations of (a) a reliance on parent report of children's physical activity levels and (b) the possibility that physical activity data within the national survey were too limited in range to show possible associations to motor skill development with higher levels of free-living physical activity in preschoolers.

  18. The Influence of International Parity on the Exchange Rate: Purchasing Power Parity and International Fisher Effect

    Directory of Open Access Journals (Sweden)

    Oana Mionel

    2012-02-01

    Full Text Available This article assesses the impact of the inflationand interest rates on the exchange rates.The analysis tests the relation between the inflation rate and the exchange rate by applying thePurchasing Power Parity Theory, while the relationbetween the interest rate and the inflation rate istested by applying the International Fisher EffectTheory. In order to test the Purchasing Power Paritythe study takes into account the period of time between 1990 – 2009, and the following countries –the USA, Germany, the UK, Switzerland, Canada, Japan and China. As for testing the InternationalFisher Effect Theory the period of time is the same, 1990 – 2009, but a few countries are different –the USA, Germany, the UK, Switzerland, Canada, Australia and New Zeeland. Thus, both theoriesanalyse the USA as home country.

  19. Male chimpanzees' grooming rates vary by female age, parity, and fertility status

    DEFF Research Database (Denmark)

    Proctor, Darby P; Lambeth, Susan P; Schapiro, Steve

    2011-01-01

    , should show little or no preference when choosing mating partners (e.g. should mate indiscriminately). To determine if the preferences indicated by copulations appear in other contexts as well as how they interact, we examined how male chimpanzees' grooming patterns varied amongst females. We found...... that males' preferences were based on interactions among females' fertility status, age, and parity. First, grooming increased with increasing female parity. We further found an effect of the estrous cycle on grooming; when females were at the lowest point of their cycle, males preferentially groomed parous...... females at peak reproductive age, but during maximal tumescence, males preferred the oldest multiparous females. Nulliparous females received relatively little grooming regardless of age or fertility. Thus, male chimpanzees apparently chose grooming partners based on both female's experience and fertility...

  20. 6-minute walk distance in healthy North Africans older than 40 years: influence of parity.

    Science.gov (United States)

    Ben Saad, Helmi; Prefaut, Christian; Tabka, Zouhair; Mtir, Abdelaziz Hadj; Chemit, Mohamed; Hassaoune, Rym; Ben Abid, Tarek; Zara, Khelifa; Mercier, Grégoire; Zbidi, Abdelkrim; Hayot, Maurice

    2009-01-01

    The need for a 6-min walk distance (6-MWD) reference equation for healthy North African adults older than 40 years was assessed in a prospective cross-sectional study. Anthropometric data and 6-MWD were measured in 229 healthy Tunisian adults (125 women) over 40 years old. Two subgroups of 38 women were identified according to the parity (lowor=6). The published reference equations did not reliably predict measured 6-MWD. The 6-MWD was significantly correlated with gender, age, weight and height (pgender (0: men; 1: women) - 5.14 x age (yr) - 2.23 x weight (kg)+2.72 x height (cm)+720.50. Parity accelerated the 6-MWD decline (r=-0.39, pparity (or=6) showed different 6-MWD (589+/-60 m vs. 555+/-57 m, pparity.

  1. Testing for purchasing power parity in 21 African countries using several unit root tests

    Science.gov (United States)

    Choji, Niri Martha; Sek, Siok Kun

    2017-04-01

    Purchasing power parity is used as a basis for international income and expenditure comparison through the exchange rate theory. However, empirical studies show disagreement on the validity of PPP. In this paper, we conduct the testing on the validity of PPP using panel data approach. We apply seven different panel unit root tests to test the validity of the purchasing power parity (PPP) hypothesis based on the quarterly data on real effective exchange rate for 21 African countries from the period 1971: Q1-2012: Q4. All the results of the seven tests rejected the hypothesis of stationarity meaning that absolute PPP does not hold in those African Countries. This result confirmed the claim from previous studies that standard panel unit tests fail to support the PPP hypothesis.

  2. Overlap between Lattice QCD and HRG with in-medium effects and parity doubling*

    Directory of Open Access Journals (Sweden)

    Morita Kenji

    2018-01-01

    Full Text Available We investigate the fluctuations and correlations involving baryon number in hot hadronic matter with modified masses of negative-parity baryons, in the context of the hadron resonance gas. Temperature-dependent masses are adopted from the recent lattice QCD results and from a chiral effective model which implements the parity doubling structure with respect to the chiral symmetry. Confronting the baryon number susceptibility, baryon-charge correlation, and baryon-strangeness correlation and their ratios with the lattice QCD data, we show that the strong downward mass shift in hyperons can accidentally reproduce some correlation ratios, however it also tends to overshoot the individual fluctuations and correlations. This indicates, that in order to correctly account for the influence of the chiral symmetry restoration on the fluctuation observables, a consistent framework of in-medium effects beyond hadron mass shifts is required.

  3. 'Parity effect' based generation of Schrodinger cat like states in high-Q microcavity

    International Nuclear Information System (INIS)

    Napoli, A.; Messina, A.

    1999-01-01

    It has been very recently shown that the dynamics of a two-level atom coupled to a bimodal degenerate cavity field by two-photon processes, is characterized by an interesting nonclassical dynamical behavior christened ''parity effect''. This effect consists in the fact that if the cavity field is prepared leaving one mode in its vacuum state and exciting the other one in a generic linear combination of even number states only, or odd number states only, then there exists an appropriate intensity-dependent interval of time after which the bimodal cavity exhibits macroscopically different parity-dependent quantum features. We show that this nonclassical effect is at the origin of the possibility of generating Schrodinger cat like states of the bimodal field appropriately selecting its initial conditions

  4. Determining the parity of a permutation using an experimental NMR qutrit

    International Nuclear Information System (INIS)

    Dogra, Shruti; Arvind,; Dorai, Kavita

    2014-01-01

    We present the NMR implementation of a recently proposed quantum algorithm to find the parity of a permutation. In the usual qubit model of quantum computation, it is widely believed that computational speedup requires the presence of entanglement and thus cannot be achieved by a single qubit. On the other hand, a qutrit is qualitatively more quantum than a qubit because of the existence of quantum contextuality and a single qutrit can be used for computing. We use the deuterium nucleus oriented in a liquid crystal as the experimental qutrit. This is the first experimental exploitation of a single qutrit to carry out a computational task. - Highlights: • NMR implementation of a quantum algorithm to determine the parity of a permutation. • Algorithm implemented on a single qutrit. • Computational speedup achieved without quantum entanglement. • Single qutrit shows quantum contextuality

  5. Hadronic electric dipole moments in R-parity violating supersymmetry

    International Nuclear Information System (INIS)

    Faessler, Amand; Gutsche, Thomas; Lyubovitskij, Valery E.; Kovalenko, Sergey

    2006-01-01

    We calculate the electric dipole moments (EDM) of the neutral 199 Hg atom, neutron and deuteron within a generic R-parity violating SUSY model (Re p SUSY) on the basis of a one-pion-exchange model with CP-odd pion-nucleon interactions. We consider two types of the Re p SUSY contributions to the above hadronic EDMs: via the quark chromoelectric dipole moments (CEDM) and CP-violating 4-quark interactions. We demonstrate that the former contributes to all the three studied EDMs while the latter appears only in the nuclear EDMs via the CP-odd nuclear forces. We find that the Re p SUSY induced 4-quark interactions arise at tree level through the sneutrino exchange and involve only s and b quarks. Therefore, their effect in hadronic EDMs is determined by the strange and bottom-quark sea of the nucleon. From the null experimental results on the hadronic EDMs we derive the limits on the imaginary parts of certain products Im(λ ' λ ' *) of the trilinear Re p -couplings and show that the currently best limits come from the 199 Hg EDM experiments. We demonstrate that some of these limits are better than those existing in the literature. We argue that future storage ring experiments on the deuteron EDM are able to improve these limits by several orders of magnitude

  6. R-parity violation in F-theory

    Energy Technology Data Exchange (ETDEWEB)

    Romão, Miguel Crispim [Physics and Astronomy, University of Southampton,SO17 1BJ Southampton (United Kingdom); Karozas, Athanasios [Physics Department, Theory Division, Ioannina University,GR-45110 Ioannina (Greece); King, Stephen F. [Physics and Astronomy, University of Southampton,SO17 1BJ Southampton (United Kingdom); Leontaris, George K. [Physics Department, Theory Division, Ioannina University,GR-45110 Ioannina (Greece); Meadowcroft, Andrew K. [Physics and Astronomy, University of Southampton,SO17 1BJ Southampton (United Kingdom)

    2016-11-14

    We discuss R-parity violation (RPV) in semi-local and local F-theory constructions. We first present a detailed analysis of all possible combinations of RPV operators arising from semi-local F-theory spectral cover constructions, assuming an SU(5) GUT. We provide a classification of all possible allowed combinations of RPV operators originating from operators of the form 10⋅5̄⋅5̄, including the effect of U(1) fluxes with global restrictions. We then relax the global constraints and perform explicit computations of the bottom/tau and RPV Yukawa couplings, at an SO(12) local point of enhancement in the presence of general fluxes subject only to local flux restrictions. We compare our results to the experimental limits on each allowed RPV operator, and show that operators such as LLe{sup c}, LQd{sup c} and u{sup c}d{sup c}d{sup c} may be present separately within current bounds, possibly on the edge of observability, suggesting lepton number violation or neutron-antineutron oscillations could constrain F-theory models.

  7. Testing and interpreting uncovered interest parity in Russia

    Directory of Open Access Journals (Sweden)

    Dmitry Vasilyev

    2017-06-01

    Full Text Available The failure of uncovered interest rate parity (UIP is a well-known phenomenon of the last thirty years. UIP failure is more prominent in advanced economies than in emerging market economies. Typically, UIP estimation for an advanced economy generates a negative coefficient, meaning that a higher interest rate in advanced economy A will result in the appreciation of economy A's exchange rate. For emerging market economies, higher interest rates usually correspond to future depreciation, although this depreciation is not sufficient for UIP to hold. This paper shows that UIP holds in Russia better than in other emerging market economies when the UIP equation accounts for a constant risk premium. Consequently, there is no forward premium puzzle for Russian data for 2001–2014. To determine the results for Russia and to compare them with the results for other countries, we estimate UIP first for Russia and then for advanced and emerging market economies using seemingly unrelated regressions and panel data analysis. By comparing the profitability of static and dynamic carry trade strategies, we also confirm that in emerging market economies, risk premiums are often constant, whereas in advanced economies, risk premiums are almost always volatile. This may explain why UIP holds better in emerging market economies. It also enables us to formulate a hypothesis that macroeconomic policies of emerging market economies (e.g., the accumulation of large foreign exchange reserves stabilize risk premiums.

  8. Optomechanically induced absorption in parity-time-symmetric optomechanical systems

    Science.gov (United States)

    Zhang, X. Y.; Guo, Y. Q.; Pei, P.; Yi, X. X.

    2017-06-01

    We explore the optomechanically induced absorption (OMIA) in a parity-time- (PT -) symmetric optomechanical system (OMS). By numerically calculating the Lyapunov exponents, we find out the stability border of the PT -symmetric OMS. The results show that in the PT -symmetric phase the system can be either stable or unstable depending on the coupling constant and the decay rate. In the PT -symmetric broken phase the system can have a stable state only for small gain rates. By calculating the transmission rate of the probe field, we find that there is an inverted optomechanically induced transparency (OMIT) at δ =-ωM and an OMIA at δ =ωM for the PT -symmetric optomechanical system. At each side of δ =-ωM there is an absorption window due to the resonance absorption of the two generated supermodes. Comparing with the case of optomechanics coupled to a passive cavity, we find that the active cavity can enhance the resonance absorption. The absorption rate at δ =ωM increases as the coupling strength between the two cavities increases. Our work provides us with a promising platform for controlling light propagation and light manipulation in terms of PT symmetry, which might have potential applications in quantum information processing and quantum optical devices.

  9. The exact parity symmetric model and big bang nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Foot, R.; Volkas, R.R.

    1996-12-01

    The assumption of exact, unbroken parity symmetry leads directly to a simple predictive resolution of the atmospheric and solar neutrino puzzles. This is because the existence of this symmetry implies the existence of a set of mirror neutrinos which must mix maximally with the known neutrinos if neutrinos have mass. the maximal mixing of the electron neutrino with the mirror electron neutrino with 3 x 10{sup -10} eV{sup 2} {<=} |{delta}m{sup 2}| {<=} 10{sup -3} eV{sup 2} leads to a predicted reduction of the solar neutrino flux by-a factor of 2, which is in quite good agreement with the experiments. The maximal mixing of the muon neutrino with the mirror muon neutrino with |{delta}m{sup 2}| {approx} 10{sup -2} eV{sup 2} also solves the atmospheric neutrino puzzle. We show that there is a significant range of parameters where these solutions are not in conflict with standard Big Bang Nucleosynthesis when the creation of lepton asymmetry due to neutrino oscillations is taken into account. (authors).

  10. Parity proofs of the Kochen–Specker theorem based on the Lie algebra E8

    International Nuclear Information System (INIS)

    Waegell, Mordecai; Aravind, P K

    2015-01-01

    The 240 root vectors of the Lie algebra E8 lead to a system of 120 rays in a real eight-dimensional Hilbert space that contains a large number of parity proofs of the Kochen–Specker (KS) theorem. After introducing the rays in a triacontagonal representation due to Coxeter, we present their KS diagram in the form of a ‘basis table’ showing all 2025 bases (i.e., sets of eight mutually orthogonal rays) formed by the rays. Only a few of the bases are actually listed, but simple rules are given, based on the symmetries of E8, for obtaining all the other bases from the ones shown. The basis table is an object of great interest because all the parity proofs of E8 can be exhibited as subsets of it. We show how the triacontagonal representation of E8 facilitates the identification of substructures that are more easily searched for their parity proofs. We have found hundreds of different types of parity proofs, ranging from 9 bases (or contexts) at the low end to 35 bases at the high end, and involving projectors of various ranks and multiplicities. After giving an overview of the proofs we found, we present a few concrete examples of the proofs that illustrate both their generic features as well as some of their more unusual properties. In particular, we present a proof involving 34 rays and 9 bases that appears to provide the most compact proof of the KS theorem found to date in eight-dimensions. (paper)

  11. 24-hour aortic blood pressure variability showed a stronger association with carotid damage than 24-hour brachial blood pressure variability: The SAFAR study.

    Science.gov (United States)

    Yu, Shikai; Chi, Chen; Protogerou, Athanase D; Safar, Michel E; Blacher, Jacques; Argyris, Antonis A; Nasothimiou, Efthimia G; Sfikakis, Petros P; Papaioannou, Theodore G; Xu, Henry; Zhang, Yi; Xu, Yawei

    2018-03-01

    We aim to compare 24-hour aortic blood pressure variability (BPV) with brachial BPV in relation to carotid damage as estimated by carotid intima-media thickness (CIMT) and cross-sectional area (CCSA). Four hundred and forty five individuals received brachial and aortic 24-hour ambulatory BP monitoring with a validated device (Mobil-O-Graph). Systolic BPV was estimated by average real variability (ARV) and time-weighted standard deviation (wSD). In multiple logistic regression analysis, CIMT > 900 μm was significantly and independently associated with aortic ARV (OR = 1.38; 95% CI: 1.04-1.84), aortic wSD (OR = 1.65; 95% CI: 1.19-2.29) and brachial ARV (OR = 1.53; 95% CI: 1.07-2.18), but not with brachial wSD. CCSA > 90th percentile was significantly and independently associated with aortic ARV (OR = 1.50; 95% CI: 1.07-2.10) and wSD (OR = 1.70; 95% CI: 1.12-2.56), but not with brachial BPVs. In receiver operator characteristics curve analysis, aortic wSD identified CCSA > 90th percentile better than brachial wSD (AUC: 0.73 vs 0.68, P < .01). In conclusion, aortic 24-hour systolic BPV showed a slightly stronger association with carotid damage than brachial BPV. ©2018 Wiley Periodicals, Inc.

  12. A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans

    Science.gov (United States)

    Acuña-Alonzo, Víctor; Flores-Dorantes, Teresa; Kruit, Janine K.; Villarreal-Molina, Teresa; Arellano-Campos, Olimpia; Hünemeier, Tábita; Moreno-Estrada, Andrés; Ortiz-López, Ma Guadalupe; Villamil-Ramírez, Hugo; León-Mimila, Paola; Villalobos-Comparan, Marisela; Jacobo-Albavera, Leonor; Ramírez-Jiménez, Salvador; Sikora, Martin; Zhang, Lin-Hua; Pape, Terry D.; de Ángeles Granados-Silvestre, Ma; Montufar-Robles, Isela; Tito-Alvarez, Ana M.; Zurita-Salinas, Camilo; Bustos-Arriaga, José; Cedillo-Barrón, Leticia; Gómez-Trejo, Celta; Barquera-Lozano, Rodrigo; Vieira-Filho, Joao P.; Granados, Julio; Romero-Hidalgo, Sandra; Huertas-Vázquez, Adriana; González-Martín, Antonio; Gorostiza, Amaya; Bonatto, Sandro L.; Rodríguez-Cruz, Maricela; Wang, Li; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A.; Lisker, Ruben; Moises, Regina S.; Menjivar, Marta; Salzano, Francisco M.; Knowler, William C.; Bortolini, M. Cátira; Hayden, Michael R.; Baier, Leslie J.; Canizales-Quinteros, Samuel

    2010-01-01

    It has been suggested that the higher susceptibility of Hispanics to metabolic disease is related to their Native American heritage. A frequent cholesterol transporter ABCA1 (ATP-binding cassette transporter A1) gene variant (R230C, rs9282541) apparently exclusive to Native American individuals was associated with low high-density lipoprotein cholesterol (HDL-C) levels, obesity and type 2 diabetes in Mexican Mestizos. We performed a more extensive analysis of this variant in 4405 Native Americans and 863 individuals from other ethnic groups to investigate genetic evidence of positive selection, to assess its functional effect in vitro and to explore associations with HDL-C levels and other metabolic traits. The C230 allele was found in 29 of 36 Native American groups, but not in European, Asian or African individuals. C230 was observed on a single haplotype, and C230-bearing chromosomes showed longer relative haplotype extension compared with other haplotypes in the Americas. Additionally, single-nucleotide polymorphism data from the Human Genome Diversity Panel Native American populations were enriched in significant integrated haplotype score values in the region upstream of the ABCA1 gene. Cells expressing the C230 allele showed a 27% cholesterol efflux reduction (P< 0.001), confirming this variant has a functional effect in vitro. Moreover, the C230 allele was associated with lower HDL-C levels (P = 1.77 × 10−11) and with higher body mass index (P = 0.0001) in the combined analysis of Native American populations. This is the first report of a common functional variant exclusive to Native American and descent populations, which is a major determinant of HDL-C levels and may have contributed to the adaptive evolution of Native American populations. PMID:20418488

  13. A parity checker circuit based on microelectromechanical resonator logic elements

    Energy Technology Data Exchange (ETDEWEB)

    Hafiz, Md Abdullah Al, E-mail: abdullah.hafiz@kaust.edu.sa [CEMSE Division, King Abdullah University of Science and Technology, Thuwal (Saudi Arabia); Li, Ren [CEMSE Division, King Abdullah University of Science and Technology, Thuwal (Saudi Arabia); Younis, Mohammad I. [PSE Division, King Abdullah University of Science and Technology, Thuwal (Saudi Arabia); Fariborzi, Hossein [CEMSE Division, King Abdullah University of Science and Technology, Thuwal (Saudi Arabia)

    2017-03-03

    Micro/nano-electromechanical resonator based logic computation has attracted significant attention in recent years due to its dynamic mode of operation, ultra-low power consumption, and potential for reprogrammable and reversible computing. Here we demonstrate a 4-bit parity checker circuit by utilizing recently developed logic gates based on MEMS resonators. Toward this, resonance frequencies of shallow arch shaped micro-resonators are electrothermally tuned by the logic inputs to constitute the required logic gates for the proposed parity checker circuit. This study demonstrates that by utilizing MEMS resonator based logic elements, complex digital circuits can be realized. - Highlights: • A 4-bit parity checker circuit is proposed and demonstrated based on MEMS resonator based logic elements. • Multiple copies of MEMS resonator based XOR logic gates are used to construct a complex logic circuit. • Functionality and feasibility of micro-resonator based logic platform is demonstrated.

  14. PARITY IN THE COSMIC MICROWAVE BACKGROUND: SPACE ODDITY

    Energy Technology Data Exchange (ETDEWEB)

    Ben-David, Assaf; Kovetz, Ely D.; Itzhaki, Nissan, E-mail: bd.assaf@gmail.com, E-mail: elykovetz@gmail.com, E-mail: nitzhaki@post.tau.ac.il [Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics and Astronomy, Tel-Aviv University, Ramat-Aviv, 69978 (Israel)

    2012-03-20

    We search for a direction in the sky that exhibits parity symmetry under reflections through a plane. We use the natural estimator, which compares the power in even and odd l + m multipoles, and apply minimal blind masking of outliers to the Internal Linear Combination map in order to avoid large errors in the reconstruction of multipoles. The multipoles of the cut sky are calculated both naively and by using the covariance inversion method, and we estimate the significance of our results using {Lambda}CDM simulations. Focusing on low multipoles, 2 {<=} l {<=} l{sub max} with l{sub max} = 5, 6, or even 7, we find two perpendicular directions of even and odd parity in the map. While the even parity direction does not appear significant, the odd direction is quite significant-at least a 3.6{sigma} effect.

  15. Fault tolerance in parity-state linear optical quantum computing

    International Nuclear Information System (INIS)

    Hayes, A. J. F.; Ralph, T. C.; Haselgrove, H. L.; Gilchrist, Alexei

    2010-01-01

    We use a combination of analytical and numerical techniques to calculate the noise threshold and resource requirements for a linear optical quantum computing scheme based on parity-state encoding. Parity-state encoding is used at the lowest level of code concatenation in order to efficiently correct errors arising from the inherent nondeterminism of two-qubit linear-optical gates. When combined with teleported error-correction (using either a Steane or Golay code) at higher levels of concatenation, the parity-state scheme is found to achieve a saving of approximately three orders of magnitude in resources when compared to the cluster state scheme, at a cost of a somewhat reduced noise threshold.

  16. R-parity violation and the cosmological gravitino problem

    International Nuclear Information System (INIS)

    Moreau, G.; Chemtob, M.

    2002-01-01

    Based on the R-parity violation option of the minimal supersymmetric standard model, we examine the scenario where the massive gravitino, a relic from the hot big-bang, is the lightest supersymmetric particle and can decay through one or several of the trilinear R-parity violating interactions. We calculate the rates of the gravitino decay via the various three-body decay channels with final states involving three quarks and/or leptons. By taking into account the present constraints on the trilinear R-parity violating coupling constants and assuming the gravitino and scalar superpartner masses do not exceed ∼80 TeV, it turns out that the gravitinos could easily have decayed before the present epoch but not earlier than the big-bang nucleosynthesis one. Therefore, the considered scenario would upset the standard big-bang nucleosynthesis scenario and we conclude that it does not seem to constitute a natural solution for the cosmological gravitino problem

  17. Parity violation in proton-proton scattering at 230 MEV

    International Nuclear Information System (INIS)

    Birchall, J.; Bowman, J.D.; Davis, C.A.

    1988-01-01

    Below /similar to/300 MeV six meson-nucleon coupling strengths are required to describe the weak interaction of nucleons. Many experiments have found parity-violating effects in nuclear systems, but only four significant, independent constraints exist. A new measurement is proposed where measurable effects are predicted with minimal dependence on nuclear interaction models, yielding information complementary to previous results. This is a measurement of the parity-violating analyzing power. A/sub z/ in p-p scattering at 230 MeV, which is shown to be sensitive to the weak rho-nucleon coupling. This measurement, at a precision of +- 2 x 10/sup -8/, together with a proposed measurement by the University of Washington group at I.L.L. of the parity-violating neutron spin rotation, will provide the fifth and sixth independent constraints needed to determine the weak meson-nucleon coupling constants

  18. Demonstration of a Sensitive Method to Measure Nuclear-Spin-Dependent Parity Violation

    Science.gov (United States)

    Altuntaş, Emine; Ammon, Jeffrey; Cahn, Sidney B.; DeMille, David

    2018-04-01

    Nuclear-spin-dependent parity violation (NSD-PV) effects in atoms and molecules arise from Z0 boson exchange between electrons and the nucleus, and from the magnetic interaction between electrons and the parity-violating nuclear anapole moment. We demonstrate measurements of NSD-PV that use an enhancement of the effect in diatomic molecules, here using the test system 138Ba 19. Our sensitivity surpasses that of any previous atomic parity violation measurement. We show that systematic errors can be suppressed to at least the level of the present statistical sensitivity. We measure the matrix element W of the NSD-PV interaction with total uncertainty δ W /(2 π )<0.7 Hz , for each of two configurations where W must have different signs. This sensitivity would be sufficient to measure NSD-PV effects of the size anticipated across a wide range of nuclei including 137Ba in 137BaF, where |W |/(2 π )≈5 Hz is expected.

  19. On the spin and parity of a single-produced resonance at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Bolognesi, Sara; Gao, Yanyan; Gritsan, Andrei V.; Melnikov, Kirill; Schulze, Markus; Tran, Nhan V.; Whitbeck, Andrew

    2012-11-01

    The experimental determination of the properties of the newly discovered boson at the Large Hadron Collider is currently the most crucial task in high energy physics. We show how information about the spin, parity, and, more generally, the tensor structure of the boson couplings can be obtained by studying angular and mass distributions of events in which the resonance decays to pairs of gauge bosons, $ZZ, WW$, and $\\gamma \\gamma$. A complete Monte Carlo simulation of the process $pp \\to X \\to VV \\to 4f$ is performed and verified by comparing it to an analytic calculation of the decay amplitudes $X \\to VV \\to 4f$. Our studies account for all spin correlations and include general couplings of a spin $J=0,1,2$ resonance to Standard Model particles. We also discuss how to use angular and mass distributions of the resonance decay products for optimal background rejection. It is shown that by the end of the 8 TeV run of the LHC, it might be possible to separate extreme hypotheses of the spin and parity of the new boson with a confidence level of 99% or better for a wide range of models. We briefly discuss the feasibility of testing scenarios where the resonances is not a parity eigenstate.

  20. Impact of multi parity on iron content in multiparous women

    International Nuclear Information System (INIS)

    Farooq, A.; Rauf, S.; Hassan, U.; Sadiq, N.

    2011-01-01

    The effect of multiple pregnancies, a very common pattern in reproductive lifestyle of Pakistani women, needs to be addressed to see if it affects the iron content and hence cause iron deficiency. Recognising this deficiency prior to development of anaemia can prevent disastrous consequences that can complicate the life of the mother and foetus especially in developing countries. The objective of this study was to assess the effect that the stress of multiple pregnancies has on the iron status of the body. Methods: This comparative study was conducted in a focus group of female population. Two hundred subjects were selected by convenient sampling and grouped depending on their parity status. Data regarding diet, and socioeconomic history was collected on pre-designed questionnaire. Serum Ferritin was used to assess iron deficiency using the Electro chemiluminescence Immunoassay (ECLIA). Data was statistically analysed using SPSS-17. Results: Mean value of serum Ferritin in the nulliparous group was 76.52 +- 4.92 eta g/mL with 16% of nulliparous subjects showing lower than normal values. Thirty-six percent of uniparous subjects showed low serum Ferritin values, mean value being 45.74 +- 4.51 eta g/mL. Seventy-two percent of the multiparous subjects showed iron deficiency with Ferritin levels of <20 eta g/mL. Mean serum Ferritin in this group was 25.21+- 2.75 g/mL. The differences between the Ferritin levels of the study groups were highly significant (p<0.01). Conclusions: Multiparous women had lower serum Ferritin levels than the control group suggesting that the stress of multiple pregnancies takes its toll on the iron content of the body. (author)

  1. Parity violation and superconductivity in doped Mott insulators

    International Nuclear Information System (INIS)

    Khveshchenko, D.Y.; Kogan, Y.I.

    1990-01-01

    The authors study parity violating states of strongly correlated two-dimensional electronic systems. On the basis of mean field theory for the SU(2N)-symmetric generalization of the system involved the authors give the arguments supporting the existence of these states at a filling number different from one-half. The authors derive an effective Lagrangian describing the long wavelength dynamics of magnetic excitations and their interaction with charged spinless holes. This paper establishes the ground state of a doped system is superconducting and discuss the phenomenological manifestations of the parity violation

  2. A parity checker circuit based on microelectromechanical resonator logic elements

    KAUST Repository

    Hafiz, Md Abdullah Al

    2017-01-11

    Micro/nano-electromechanical resonator based logic computation has attracted significant attention in recent years due to its dynamic mode of operation, ultra-low power consumption, and potential for reprogrammable and reversible computing. Here we demonstrate a 4-bit parity checker circuit by utilizing recently developed logic gates based on MEMS resonators. Toward this, resonance frequencies of shallow arch shaped micro resonators are electrothermally tuned by the logic inputs to constitute the required logic gates for the proposed parity checker circuit. This study demonstrates that by utilizing MEMS resonator based logic elements, complex digital circuits can be realized.

  3. Parity violation and superconductivity in doped Mott insulators

    International Nuclear Information System (INIS)

    Khveshchenko, D.V.; Kogan, Ya.I.

    1989-12-01

    We study parity violating states of strongly correlated two-dimensional electronic systems. On the basis of mean field theory for the SU(2N)-symmetric generalization of the system involved we give the arguments supporting the existence of these states at a filling number different from one-half. We derive an effective Lagrangian describing the long wavelength dynamics of magnetic excitations and their interaction with charged spinless holes. We establish that the ground state of a doped system is superconducting and discuss the phenomenological manifestations of the parity violation. (author). 48 refs, 3 figs

  4. New even and odd parity levels of neutral praseodymium

    International Nuclear Information System (INIS)

    Syed, T I; Siddiqui, I; Shamim, K; Uddin, Z; Guthöhrlein, G H; Windholz, L

    2011-01-01

    The hyperfine (hf) structure of some spectral lines of the praseodymium atom has been investigated by the laser-induced fluorescence method in a hollow cathode discharge lamp. We report the discovery of 18 new energy levels of even parity and 22 new energy levels of odd parity and their magnetic dipole hf interaction constants A. Using these newly discovered levels, 268 lines were classified by means of laser spectroscopy, 97 of them by laser excitation and 171 via laser-induced fluorescence. In addition, 23 lines, observed in a Fourier transform spectrum, were classified by means of their wavenumbers and their hf patterns.

  5. Minimal flavour violation and neutrino masses without R-parity

    DEFF Research Database (Denmark)

    Arcadi, G.; Di Luzio, L.; Nardecchia, M.

    2012-01-01

    symmetry breaking all the couplings of the superpotential including the R-parity violating ones. If R-parity violation is responsible for neutrino masses, our setup can be seen as an extension of MFV to the lepton sector. We analyze two patterns based on the non-abelian flavour symmetries SU(3)(4) circle...... times SU(4) and SU(3)(5). In the former case the total lepton number and the lepton flavour number are broken together, while in the latter the lepton number can be broken independently by an abelian spurion, so that visible effects and peculiar correlations can be envisaged in flavour changing charged...

  6. A parity checker circuit based on microelectromechanical resonator logic elements

    KAUST Repository

    Hafiz, Md Abdullah Al; Li, Ren; Younis, Mohammad I.; Fariborzi, Hossein

    2017-01-01

    Micro/nano-electromechanical resonator based logic computation has attracted significant attention in recent years due to its dynamic mode of operation, ultra-low power consumption, and potential for reprogrammable and reversible computing. Here we demonstrate a 4-bit parity checker circuit by utilizing recently developed logic gates based on MEMS resonators. Toward this, resonance frequencies of shallow arch shaped micro resonators are electrothermally tuned by the logic inputs to constitute the required logic gates for the proposed parity checker circuit. This study demonstrates that by utilizing MEMS resonator based logic elements, complex digital circuits can be realized.

  7. Ecological Diversity in South American Mammals: Their Geographical Distribution Shows Variable Associations with Phylogenetic Diversity and Does Not Follow the Latitudinal Richness Gradient.

    Directory of Open Access Journals (Sweden)

    Paula Nilda Fergnani

    Full Text Available The extent to which the latitudinal gradient in species richness may be paralleled by a similar gradient of increasing functional or phylogenetic diversity is a matter of controversy. We evaluated whether taxonomic richness (TR is informative in terms of ecological diversity (ED, an approximation to functional diversity and phylogenetic diversity (AvPD using data on 531 mammal species representing South American old autochthonous (marsupials, xenarthrans, mid-Cenozoic immigrants (hystricognaths, primates and newcomers (carnivorans, artiodactyls. If closely related species are ecologically more similar than distantly related species, AvPD will be a strong predictor of ED; however, lower ED than predicted from AvPD may be due to species retaining most of their ancestral characters, suggesting niche conservatism. This pattern could occur in tropical rainforests for taxa of tropical affinity (old autochthonous and mid-Cenozoic immigrants and in open and arid habitats for newcomers. In contrast, higher ED than expected from AvPD could occur, possibly in association with niche evolution, in arid and open habitats for taxa of tropical affinity and in forested habitats for newcomers. We found that TR was a poor predictor of ED and AvPD. After controlling for TR, there was considerable variability in the extent to which AvPD accounted for ED. Taxa of tropical affinity did not support the prediction of ED deficit within tropical rainforests, rather, they showed a mosaic of regions with an excess of ED interspersed with zones of ED deficit within the tropics; newcomers showed ED deficit in arid and open regions. Some taxa of tropical affinity showed excess of ED in tropical desert areas (hystricognaths or temperate semideserts (xenarthrans; newcomers showed excess of ED at cold-temperate latitudes in the Northern Hemisphere. This result suggests that extreme climatic conditions at both temperate and tropical latitudes may have promoted niche evolution in

  8. Novel Method To Identify Source-Associated Phylogenetic Clustering Shows that Listeria monocytogenes Includes Niche-Adapted Clonal Groups with Distinct Ecological Preferences

    DEFF Research Database (Denmark)

    Nightingale, K. K.; Lyles, K.; Ayodele, M.

    2006-01-01

    population are identified (TreeStats test). Analysis of sequence data for 120 L. monocytogenes isolates revealed evidence of clustering between isolates from the same source, based on the phylogenies inferred from actA and inlA (P = 0.02 and P = 0.07, respectively; SourceCluster test). Overall, the Tree...... are biologically valid. Overall, our data show that (i) the SourceCluster and TreeStats tests can identify biologically meaningful source-associated phylogenetic clusters and (ii) L. monocytogenes includes clonal groups that have adapted to infect specific host species or colonize nonhost environments......., including humans, animals, and food. If the null hypothesis that the genetic distances for isolates within and between source populations are identical can be rejected (SourceCluster test), then particular clades in the phylogenetic tree with significant overrepresentation of sequences from a given source...

  9. Members of the barley NAC transcription factor gene family show differential co-regulation with senescence-associated genes during senescence of flag leaves

    DEFF Research Database (Denmark)

    Christiansen, Michael W; Gregersen, Per L.

    2014-01-01

    -expressed with members of the NAC gene family. In conclusion, a list of up to 15 NAC genes from barley that are strong candidates for being regulatory factors of importance for senescence and biotic stress-related traits affecting the productivity of cereal crop plants has been generated. Furthermore, a list of 71...... in the NAC transcription factor family during senescence of barley flag leaves was studied. Several members of the NAC transcription factor gene family were up-regulated during senescence in a microarray experiment, together with a large range of senescence-associated genes, reflecting the coordinated...... activation of degradation processes in senescing barley leaf tissues. This picture was confirmed in a detailed quantitative reverse transcription–PCR (qRT–PCR) experiment, which also showed distinct gene expression patterns for different members of the NAC gene family, suggesting a group of ~15 out of the 47...

  10. A carcinoma showing thymus-like elements of the thyroid arising in close association with solid cell nests: evidence for a precursor lesion?

    Science.gov (United States)

    Yerly, Stéphane; Lobrinus, Johannes-Alexander; Bongiovanni, Massimo; Becker, Minerva; Zare, Maryam; Granger, Perrine; Pusztaszeri, Marc

    2013-04-01

    Carcinoma showing thymus-like elements (CASTLE) is a rare malignant neoplasm of the thyroid gland, morphologically and immunohistologically similar to a thymic carcinoma, whose histogenesis is still debated. Hypotheses include an origin from ectopic thymic tissue, vestige of the thymopharyngeal duct, or branchial pouch remnants from which solid cell nests (SC-nests) originate. The diagnosis of CASTLE may be treacherous due to its rarity and its propensity to mimic other poorly differentiated tumors such as squamous cell carcinoma. We present a case of CASTLE in a 58-year-old man initially diagnosed as a poorly differentiated squamous cell carcinoma both on fine-needle aspiration cytology (FNAC) and on biopsy, arising in close association with SC-nests. A thorough literature review, with special emphasis on its diagnosis and histogenesis of CASTLE, was also conducted. Magnetic resonance images revealed a 4.0-cm cervical mass on the left side of the trachea, involving the lateral middle/inferior portion of the left lobe of the thyroid gland. FNAC was performed with a diagnosis of "malignant cells, consistent with squamous cell carcinoma." A histological evaluation of the resected specimen revealed a malignant proliferation of cells, focally exhibiting a squamoid appearance, which were immunopositive for CD5 and p63. A diagnosis of CASTLE was made. The tumor was located in direct continuity with SC-Nests, and the cell morphology of both the SC-nests and CASTLE was very similar with merging. Moreover, the immunohistochemical expression profiles of most markers useful in the diagnosis of CASTLE were identical in the SC-nests. The inclusion of CASTLE in the differential diagnosis of poorly differentiated tumors of the thyroid region and the use of ancillary studies are essential to diagnose this rare entity associated with a relatively favorable prognosis. The close association of CASTLE with SC-nests opens the way to a new scenario for studies of its histogenesis.

  11. Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients

    Directory of Open Access Journals (Sweden)

    Philip ePrinz

    2015-06-01

    Full Text Available Bile acids may be involved in the regulation of food intake and energy metabolism. The aim of the study was to investigate the association of plasma bile acids with body mass index (BMI and the possible involvement of circulating bile acids in the modulation of physical activity and eating behavior. Blood was obtained in a group of hospitalized patients with normal weight (BMI 18.5-25 kg/m2, underweight (anorexia nervosa, BMI 50 kg/m2, n=14-15/group and plasma bile acid concentrations assessed. Physical activity and plasma bile acids were measured in a group of patients with anorexia nervosa (BMI 14.6±0.3 kg/m2, n=43. Lastly, in a population of obese patients (BMI 48.5±0.9 kg/m2, n=85, psychometric parameters related to disordered eating and plasma bile acids were assessed. Plasma bile acids showed a positive correlation with BMI (r=0.26, p=0.03 in the population of patients with broad range of BMI (9-85 kg/m2, n=74. No associations were observed between plasma bile acids and different parameters of physical activity in anorexic patients (p>0.05. Plasma bile acids were negatively correlated with cognitive restraint of eating (r=-0.30, p=0.008, while no associations were observed with other psychometric eating behavior-related parameters (p>0.05 in obese patients. In conclusion, these data may point towards a role of bile acids in the regulation of body weight. Since plasma bile acids are negatively correlated with the cognitive restraint of eating in obese patients, this may represent a compensatory adaptation to prevent further overeating.

  12. Requests and usage of epidural analgesia in grand-grand multiparous and similar-aged women with lesser parity: prospective observational study.

    Science.gov (United States)

    Ioscovich, Alexander; Fadeev, Angelika; Rivilis, Alina; Elstein, Deborah

    2011-11-01

    Epidural analgesia in older and multiparous women has been associated with risks. The aim of this study was to compare epidural analgesia use for labor/delivery in grand-grand multiparous women (GGMP; ≥10 births) relative to that in similar-aged women with lesser parity. This was a prospective observational study of advanced age gravida. All laboring women in a six-month period admitted to a tertiary Israeli center were included if they were advanced age (≥36 years old) with one to two previous births (Low parity; n=128) or four to five previous births (Medium parity; n=181), and all GGMP (any age; n=187). Primary outcome was comparison of requests for and use of epidural analgesia for labor/delivery. There were no significant differences across parity groups in percent of gravida requesting or receiving epidural analgesia (46.5-59.4%). Time from admission to epidural administration (range mean times: 168-187 min) and from advent of epidural to delivery (range mean times: 155-160 min) were comparable across parity groups. Use of other analgesia (5.8-8%) was not significantly different. Requests for and use of epidural analgesia was comparable in older gravida and was not correlated with parity. Mean times from presentation to epidural administration, mean cervical dilatation at epidural initiation, and mean time from performing of epidural to delivery were comparable across groups.

  13. Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential.

    Science.gov (United States)

    Dong, Qiaoxiang; Gao, Hui; Shi, Yuanshuo; Zhang, Fuchuang; Gu, Xiang; Wu, Anqi; Wang, Danhan; Chen, Yuanhong; Bandyopadhyay, Abhik; Yeh, I-Tien; Daniel, Benjamin J; Chen, Yidong; Zou, Yi; Rebel, Vivienne L; Walter, Christi A; Lu, Jianxin; Huang, Changjiang; Sun, Lu-Zhe

    2016-11-15

    Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old mammary glands of different cohorts of C57BL6/J and BALB/c mice, and our findings revealed that old mammary glands were characterized by increased basal cell pool comprised of mostly CD49f hi cells, altered luminal-to-basal cell ratio, and irregular ductal morphology. More interestingly, basal stem cells in old mice were increased in frequency, but showed a functional decline of differentiation and increased neoplastic transformation potential. Gene signature enrichment analysis revealed a significant enrichment of a luminal cell gene expression signature in the basal stem cell-enriched population from old mice, suggesting some luminal cells were expressing basal markers. Immunofluorescence staining confirmed the presence of luminal cells with high CD49f expression in hyperplastic lesions implicating these cells as undergoing luminal to basal phenotypic changes during aging. Whole transcriptome analysis showed elevated immune and inflammatory responses in old basal stem cells and stromal cells, which may be the underlying cause for increased CD49f hi basal-like cells in aged glands.

  14. Characterization of genomic sequence showing strong association with polyembryony among diverse Citrus species and cultivars, and its synteny with Vitis and Populus.

    Science.gov (United States)

    Nakano, Michiharu; Shimada, Takehiko; Endo, Tomoko; Fujii, Hiroshi; Nesumi, Hirohisa; Kita, Masayuki; Ebina, Masumi; Shimizu, Tokurou; Omura, Mitsuo

    2012-02-01

    Polyembryony, in which multiple somatic nucellar cell-derived embryos develop in addition to the zygotic embryo in a seed, is common in the genus Citrus. Previous genetic studies indicated polyembryony is mainly determined by a single locus, but the underlying molecular mechanism is still unclear. As a step towards identification and characterization of the gene or genes responsible for nucellar embryogenesis in Citrus, haplotype-specific physical maps around the polyembryony locus were constructed. By sequencing three BAC clones aligned on the polyembryony haplotype, a single contiguous draft sequence consisting of 380 kb containing 70 predicted open reading frames (ORFs) was reconstructed. Single nucleotide polymorphism genotypes detected in the sequenced genomic region showed strong association with embryo type in Citrus, indicating a common polyembryony locus is shared among widely diverse Citrus cultivars and species. The arrangement of the predicted ORFs in the characterized genomic region showed high collinearity to the genomic sequence of chromosome 4 of Vitis vinifera and linkage group VI of Populus trichocarpa, suggesting that the syntenic relationship among these species is conserved even though V. vinifera and P. trichocarpa are non-apomictic species. This is the first study to characterize in detail the genomic structure of an apomixis locus determining adventitious embryony. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  15. Separate Influences of Birth Order and Gravidity/Parity on the Development of Systemic Sclerosis

    Science.gov (United States)

    COCKRILL, TONYA; del JUNCO, DEBORAH J.; ARNETT, FRANK C.; ASSASSI, SHERVIN; TAN, FILEMON K.; McNEARNEY, TERRY; FISCHBACH, MICHAEL; PERRY, MARILYN; MAYES, MAUREEN D.

    2010-01-01

    Objective Birth order has been valuable in revealing the role of environmental influences on the risk of developing certain diseases such as allergy and atopy. In addition, pregnancy has profound effects on the immune system such as short-term effects that permit fetal survival as well as longer-term effects that could influence late-onset diseases. In order to better evaluate these influences, we studied the association of birth order and gravidity/parity as risk factors for systemic sclerosis (SSc; scleroderma). Methods Data regarding SSc cases and their unaffected sibling controls were obtained from the Scleroderma Family Registry and DNA Repository. The case-sibling design was used to minimize confounding due to differences in age, race, ethnicity, or calendar time. The gravidity/parity analysis was based on sibships with at least one SSc-affected and one unaffected sister. Results Birth order was examined in 974 sibships, comparing SSc cases (n = 987) with their unaffected siblings (n = 3,088). The risk of scleroderma increased with increasing birth order (odds ratio [OR] 1.25, 95% confidence interval [95% CI] 1.06–1.50 for birth order 2–5; OR 2.22, 95% CI 1.57–3.15 for birth order 6–9; and OR 3.53, 95% CI 1.68–7.45 for birth order 10–15). Gravidity/parity was analyzed in 168 sibships (256 unaffected sisters, 172 SSc cases). We found an association between a history of one or more pregnancies and SSc (OR 2.8). Conclusion Birth order and pregnancy were independently associated with a higher risk of developing SSc. These findings suggest that immune development in early childhood and/or pregnancy-associated events, including but not limited to microchimerism, plays a role in SSc susceptibility. PMID:20391489

  16. Separate influences of birth order and gravidity/parity on the development of systemic sclerosis.

    Science.gov (United States)

    Cockrill, Tonya; del Junco, Deborah J; Arnett, Frank C; Assassi, Shervin; Tan, Filemon K; McNearney, Terry; Fischbach, Michael; Perry, Marilyn; Mayes, Maureen D

    2010-03-01

    Birth order has been valuable in revealing the role of environmental influences on the risk of developing certain diseases such as allergy and atopy. In addition, pregnancy has profound effects on the immune system such as short-term effects that permit fetal survival as well as longer-term effects that could influence late-onset diseases. In order to better evaluate these influences, we studied the association of birth order and gravidity/parity as risk factors for systemic sclerosis (SSc; scleroderma). Data regarding SSc cases and their unaffected sibling controls were obtained from the Scleroderma Family Registry and DNA Repository. The case-sibling design was used to minimize confounding due to differences in age, race, ethnicity, or calendar time. The gravidity/parity analysis was based on sibships with at least one SSc-affected and one unaffected sister. Birth order was examined in 974 sibships, comparing SSc cases (n = 987) with their unaffected siblings (n = 3,088). The risk of scleroderma increased with increasing birth order (odds ratio [OR] 1.25, 95% confidence interval [95% CI] 1.06-1.50 for birth order 2-5; OR 2.22, 95% CI 1.57-3.15 for birth order 6-9; and OR 3.53, 95% CI 1.68-7.45 for birth order 10-15). Gravidity/parity was analyzed in 168 sibships (256 unaffected sisters, 172 SSc cases). We found an association between a history of one or more pregnancies and SSc (OR 2.8). Birth order and pregnancy were independently associated with a higher risk of developing SSc. These findings suggest that immune development in early childhood and/or pregnancy-associated events, including but not limited to microchimerism, plays a role in SSc susceptibility.

  17. A novel DFNB31 mutation associated with Usher type 2 syndrome showing variable degrees of auditory loss in a consanguineous Portuguese family.

    Science.gov (United States)

    Audo, Isabelle; Bujakowska, Kinga; Mohand-Saïd, Saddek; Tronche, Sophie; Lancelot, Marie-Elise; Antonio, Aline; Germain, Aurore; Lonjou, Christine; Carpentier, Wassila; Sahel, José-Alain; Bhattacharya, Shomi; Zeitz, Christina

    2011-01-01

    To identify the genetic defect of a consanguineous Portuguese family with rod-cone dystrophy and varying degrees of decreased audition. A detailed ophthalmic and auditory examination was performed on a Portuguese patient with severe autosomal recessive rod-cone dystrophy. Known genetic defects were excluded by performing autosomal recessive retinitis pigmentosa (arRP) genotyping microarray analysis and by Sanger sequencing of the coding exons and flanking intronic regions of eyes shut homolog-drosophila (EYS) and chromosome 2 open reading frame 71 (C2orf71). Subsequently, genome-wide homozygosity mapping was performed in DNA samples from available family members using a 700K single nucleotide polymorphism (SNP) microarray. Candidate genes present in the significantly large homozygous regions were screened for mutations using Sanger sequencing. The largest homozygous region (~11 Mb) in the affected family members was mapped to chromosome 9, which harbors deafness, autosomal recessive 31 (DFNB31; a gene previously associated with Usher syndrome). Mutation analysis of DFNB31 in the index patient identified a novel one-base-pair deletion (c.737delC), which is predicted to lead to a truncated protein (p.Pro246HisfsX13) and co-segregated with the disease in the family. Ophthalmic examination of the index patient and the affected siblings showed severe rod-cone dystrophy. Pure tone audiometry revealed a moderate hearing loss in the index patient, whereas the affected siblings were reported with more profound and early onset hearing impairment. We report a novel truncating mutation in DFNB31 associated with severe rod-cone dystrophy and varying degrees of hearing impairment in a consanguineous family of Portuguese origin. This is the second report of DFNB31 implication in Usher type 2.

  18. An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males.

    Science.gov (United States)

    Do, Thuy N; Ucisik-Akkaya, Esma; Davis, Charronne F; Morrison, Brittany A; Dorak, M Tevfik

    2010-02-01

    The interferon regulatory factor (IRF) family of DNA-binding proteins regulates expression of interferon-inducible genes with roles in the immune response and carcinogenesis. IRF4 is involved in the differentiation of B and T cells and is overexpressed in B-cell malignancies as a result of c-REL (NF-kappaB) hyperactivation. IRF4 polymorphisms are associated with susceptibility to chronic lymphoid leukemia (CLL) and non-Hodgkin lymphoma (NHL). We examined 13 IRF4 SNPs in 114 cases of childhood acute lymphoblastic leukemia (ALL) and 388 newborn controls from Wales (U.K.) using TaqMan assays. IRF4 intron 4 SNP rs12203592 showed a male-specific risk association (OR=4.4, 95% CI=1.5 to 12.6, P=0.007). Functional consequences of the C>T substitution at this SNP were assessed by cell-based reporter assays using three different cell lines. We found a repressive effect of the rs12203592 wildtype allele C on IRF4 promoter activity (Pcell line tested. Thus, homozygosity for the rs12203592 variant allele would result in increased IRF4 expression. This increase would be compounded by high levels of NF-kappaB activity in males due to the absence of estrogen. IRF4 differs from other IRFs in its anti-interferon activity which interferes with immune surveillance. We propose that a detailed study of IRF4 can provide information on the mechanism of the sex effect and the role of immune surveillance in childhood ALL development. Copyright 2009 Elsevier B.V. All rights reserved.

  19. From parity violation to hadronic structure and more

    CERN Document Server

    Jager, K; Kox, S; Lhuillier, D; Maas, F; Page, S; Papanicolas, C; Stiliaris, S; Wiele, J; 3rd International Workshop on From Parity Violation to Hadronic Structure and More (PAVI06); PAVI 06; PAVI 2006

    2007-01-01

    This book contains the proceedings of the third international workshop on “From Parity Violation to Hadronic Structure and more ...” which was held from May 16 to May 20, 2006, at the George Eliopoulos conference center on the Greek island of Milos. It is part of a series that started in Mainz in 2002 and was followed by a second workshop in Grenoble in 2004. While originally initiated by the extraction of the strangeness contribution to the electromagnetic form factors of the nucleon, the workshop series has continuously broadened the focus to the application of Parity Violation using hadronic probes and to Parity Violation experiments in atomic physics. Meanwhile there have been many exciting new proposals for using Parity Violation in other areas like in the search for new physics beyond the standard model or in exploring hadron structure. There are also close connections to the open question on the size of the two photon exchange amplitude. Fifty years after the 1956 proposal of Lee and Yang to test t...

  20. Analysis tools for discovering strong parity violation at hadron colliders

    Science.gov (United States)

    Backović, Mihailo; Ralston, John P.

    2011-07-01

    Several arguments suggest parity violation may be observable in high energy strong interactions. We introduce new analysis tools to describe the azimuthal dependence of multiparticle distributions, or “azimuthal flow.” Analysis uses the representations of the orthogonal group O(2) and dihedral groups DN necessary to define parity completely in two dimensions. Classification finds that collective angles used in event-by-event statistics represent inequivalent tensor observables that cannot generally be represented by a single “reaction plane.” Many new parity-violating observables exist that have never been measured, while many parity-conserving observables formerly lumped together are now distinguished. We use the concept of “event-shape sorting” to suggest separating right- and left-handed events, and we discuss the effects of transverse and longitudinal spin. The analysis tools are statistically robust, and can be applied equally to low or high multiplicity events at the Tevatron, RHIC or RHIC Spin, and the LHC.

  1. The uncovered parity properties of the Czech Koruna

    Czech Academy of Sciences Publication Activity Database

    Derviz, Alexis

    2002-01-01

    Roč. 11, č. 1 (2002), s. 17-37 ISSN 1210-0455 R&D Projects: GA AV ČR KSK1019101 Institutional research plan: CEZ:AV0Z1075907 Keywords : uncovered parity * asset prices * international consumption-based capital asset pricing model Subject RIV: AH - Economics

  2. Weak interactions, quark masses and spontaneous violation of parity

    International Nuclear Information System (INIS)

    Kingsley, R.L.

    1976-09-01

    A six quark model is discussed for the weak interactions of hadrons in which parity is violated spontaneously in an SU(2) x U(1) gauge theory. Quarks with very small masses are required and their weak interactions approximate those of the Weinberg-Salam model. Suppression of strangeness-changing neutral currents requires at least seven quarks. (author)

  3. 7 CFR 989.61 - Above parity situations.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Above parity situations. 989.61 Section 989.61 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...) of the act. [42 FR 37202, July 20, 1977] Trade Practices ...

  4. Parity violation workshop: CEBAF [Continuous Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    Walecka, J.D.

    1986-01-01

    This paper discusses the use of electron scattering experiments for exploring parity violation in the nuclear domain. It is shown how such experiments can test the structure of strong interactions, the local gauge theory quantum chromodynamics based on color, and the unified gauge theory of electroweak interactions. 14 refs., 13 figs., 1 tab

  5. Purchasing Power Parity : Evidence from a New Test

    NARCIS (Netherlands)

    Klaassen, F.J.G.M.

    1999-01-01

    Most economists intuitively consider purchasing power parity (PPP) to be true. Nevertheless, quite surprisingly, the empirical literature is not very supportive for PPP. In this paper, however, we find evidence in favor of PPP using a new test. The test is embedded in a Markov regime-switching model

  6. A brief survey of atomic parity nonconservation experiments

    International Nuclear Information System (INIS)

    He Maoqi; Zhao Youyuan; Cai Shengshan; Zhang ZHiming

    1990-01-01

    The authors present a brief description of the basic idea of atomic parity nonconservation (PNC) effect, introduce the methods and results of measuring PNC, analyse the reasons to continue with atomic PNC experiments and suggest some ideas to improve the measure of PNC

  7. Violation of G-parity in antinucleon-nucleon annihilation

    International Nuclear Information System (INIS)

    Green, A.M.; Sainio, M.E.; Moussallam, B.; Niskanen, J.A.; Wycech, S.

    1991-01-01

    A strategy is proposed for investigating the violation of G-parity in the annihilation reaction anti np → π + π 0 . As illustrations π 0 -η mixing and the mass difference effects are considered. This leads to an asymmetry of about 1% in the cross section. (orig.)

  8. Violation of interest-rate parity: a Polish example

    Science.gov (United States)

    Przystawa, Jerzy; Wolf, Marek

    2000-09-01

    The mechanism of the so-called “Bagsik Oscillator” is presented and discussed. In essence, it is a repeated exploitation of arbitrage opportunities that resulted from a marked departure from the interest-rate parity relationship between the local Polish currency and the western currencies.

  9. Nuclear isospin mixing and elastic parity-violating electron scattering

    International Nuclear Information System (INIS)

    Moreno, O.; Sarriguren, P.; Moya de Guerra, E.; Udias, J.M.; Donnelly, T.W.; Sick, I.

    2009-01-01

    The influence of nuclear isospin mixing on parity-violating elastic electron scattering is studied for the even-even, N=Z nuclei 12 C, 24 Mg, 28 Si, and 32 S. Their ground-state wave functions have been obtained using a self-consistent axially-symmetric mean-field approximation with density-dependent effective two-body Skyrme interactions. Some differences from previous shell-model calculations appear for the isovector Coulomb form factors which play a role in determining the parity-violating asymmetry. To gain an understanding of how these differences arise, the results have been expanded in a spherical harmonic oscillator basis. Results are obtained not only within the plane-wave Born approximation, but also using the distorted-wave Born approximation for comparison with potential future experimental studies of parity-violating electron scattering. To this end, for each nucleus the focus is placed on kinematic ranges where the signal (isospin-mixing effects on the parity-violating asymmetry) and the experimental figure-of-merit are maximized. Strangeness contributions to the asymmetry are also briefly discussed, since they and the isospin mixing contributions may play comparable roles for the nuclei being studied at the low momentum transfers of interest in the present work.

  10. Contribution of working memory in the parity and proportional judgments

    NARCIS (Netherlands)

    Szymanik, J.K.; Zajenkowski, M.

    2011-01-01

    This paper presents experimental evidence on the differences in a sentence-picture verification task under additional memory load between parity and proportional quantifiers. We asked subjects to memorize strings of four or six digits, then to decide whether a quantified sentence was true for a

  11. Efficient Instantiation of Parameterised Boolean Equation Systems to Parity Games

    NARCIS (Netherlands)

    Kant, Gijs; van de Pol, Jan Cornelis; Wijs, A.J.; Bošnački, D.; Edelkamp, S.

    Parameterised Boolean Equation Systems (PBESs) are sequences of Boolean fixed point equations with data variables, used for, e.g., verification of modal μ-calculus formulae for process algebraic specifications with data. Solving a PBES is usually done by instantiation to a Parity Game and then

  12. Hadronic parity violation and inelastic electron-deuteron scattering

    International Nuclear Information System (INIS)

    Liu, C.-P.; Prezeau, G.; Ramsey-Musolf, M.J.

    2003-01-01

    We compute contributions to the parity-violating (PV) inelastic electron-deuteron scattering asymmetry arising from hadronic PV. While hadronic PV effects can be relatively important in PV threshold electrodisintegration, we find that they are highly suppressed at quasielastic kinematics. The interpretation of the PV quasielastic asymmetry is, thus, largely unaffected by hadronic PV

  13. Parity non-conserving effects in neutron-nucleus scattering

    International Nuclear Information System (INIS)

    Desplanques, B.

    1990-01-01

    The present lecture reviews the motivations which led to study the contribution of the neutron-nucleus component to parity-non-conserving effects observed in medium-heavy nuclei and considers its present status. It is shown that it cannot account for those experimental data. The order interpretation of these effects, which cannot lead to precise statements, is schematically described

  14. Parity and carotid atherosclerosis in men and women: insights into the roles of childbearing and child-rearing.

    Science.gov (United States)

    Skilton, Michael R; Sérusclat, André; Begg, Lisa M; Moulin, Philippe; Bonnet, Fabrice

    2009-04-01

    Parity appears to be associated with carotid atherosclerosis in women aged 45 years and older. Studying this association among younger women and men may provide insight into whether this association relates predominantly to childbearing or child-rearing. The association between parity and carotid atherosclerosis (intima-media thickness and presence of plaques) was assessed in a cohort consisting of 750 women and 1164 men, all with at least one traditional cardiovascular risk factor, aged 18 to 80 years of age. Traditional cardiovascular risk factors were also assessed, and the Framingham Risk Score calculated. In age-adjusted analyses, the number of children was associated with adiposity, fasting glucose, 2-hour glucose, Framingham risk score, and carotid atherosclerosis in women, but not in men. Multivariate linear regression models indicate that the prevalence of plaques was increased by 15% (95% CI, 2 to 29) per child among women, and 0% (95% CI, -10 to 11) among men, after adjustment for age, socioeconomic and lifestyle factors (including waist circumference). The association between parity and carotid intima-media thickness was similar in younger and older women (P(Heterogeneity)=0.20). A higher number of children is associated with increased carotid atherosclerosis in both younger and older women, but not among men. These findings indicate that childbearing, but not child-rearing, may be a risk factor for atherosclerosis, and suggest the potential importance of considering the number of children when assessing the level of cardiovascular risk in women.

  15. Photonic entanglement-assisted quantum low-density parity-check encoders and decoders.

    Science.gov (United States)

    Djordjevic, Ivan B

    2010-05-01

    I propose encoder and decoder architectures for entanglement-assisted (EA) quantum low-density parity-check (LDPC) codes suitable for all-optical implementation. I show that two basic gates needed for EA quantum error correction, namely, controlled-NOT (CNOT) and Hadamard gates can be implemented based on Mach-Zehnder interferometer. In addition, I show that EA quantum LDPC codes from balanced incomplete block designs of unitary index require only one entanglement qubit to be shared between source and destination.

  16. Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma

    Directory of Open Access Journals (Sweden)

    Staton Carolyn A

    2011-03-01

    shows dissociation of the co-regulation of NRP-1 and EEC. Conclusion NRP-1 is inversely associated with levels of butyrate and other SCFA in vivo and is expressed in a subset of CgA expressing cells. EEC number is related to butyrate level in the same way.

  17. Purchasing power parity theory in a model without international trade of goods

    OpenAIRE

    Läufer, Nikolaus K. A.

    1980-01-01

    In recent discussions it frequently occurs that the Purchasing Power Parity Theory is identified with Jevons law of one price. By pointing to real world obstacles working against perfect goods arbitrage it is then erroneously concluded that the Purchasing Power Parity Theory cannot be valid while a dinstiction between an absolute version and a relative version of the Purchasing Power Parity Theory is neglected. In the present paper it is shown that the Purchasing Power Parity Theory in the re...

  18. Compelling Diversities, Educational Intersections: Policy, Practice, Parity

    Science.gov (United States)

    Taylor, Yvette

    2013-01-01

    The ninth international Gender and Education Association Conference "Compelling Diversities, Educational Intersections" hosted by the Weeks Centre for Social and Policy Research, London South Bank University engages with key debates surrounding the interplay between dynamics of education, work, employment and society in the context of…

  19. Cardiac Vagal Tone and Quality of Parenting Show Concurrent and Time-Ordered Associations That Diverge in Abusive, Neglectful, and Non-Maltreating Mothers

    Science.gov (United States)

    Skowron, Elizabeth A.; Cipriano-Essel, Elizabeth; Benjamin, Lorna Smith; Pincus, Aaron L.; Van Ryzin, Mark J.

    2014-01-01

    Concurrent and lagged maternal respiratory sinus arrhythmia (RSA) was monitored in the context of parenting. One hundred and forty-one preschooler-mother dyads—involved with child welfare as documented perpetrators of child abuse or neglect, or non-maltreating (non-CM)—were observed completing a resting baseline and joint challenge task. Parenting behaviors were coded using SASB (Benjamin, 1996) and maternal RSA was simultaneously monitored, longitudinally-nested within-person (WP), and subjected to MLM. Abusive and neglectful mothers displayed less positive parenting and more strict/hostile control, relative to non-CM mothers. Non-CM mothers displayed greater WP heterogeneity in variance over time in their RSA scores, and greater consistency over time in their parenting behaviors, relative to abusive or neglectful mothers. CM group also moderated concurrent and lagged WP associations in RSA and positive parenting. When abusive mothers displayed lower RSA in a given epoch, relative to their task average, they showed concurrent increases in positive parenting, and higher subsequent levels of hostile control in the following epoch, suggesting that it is physiologically taxing for abusive mothers to parent in positive ways. In contrast, lagged effects for non-CM mothers were observed in which RSA decreases led to subsequent WP increases in positive parenting and decreases in control. Reversed models were significant only for neglectful mothers: Increases in positive parenting led to subsequent increases in RSA levels, and increases in strict, hostile control led to subsequent RSA decreases. These results provide new evidence that concurrent and time-ordered coupling in maternal physiology and behavior during parenting vary in theoretically meaningful ways across CM and non-CM mothers. Implications for intervention and study limitations are discussed. PMID:24729945

  20. Cardiac Vagal Tone and Quality of Parenting Show Concurrent and Time-Ordered Associations That Diverge in Abusive, Neglectful, and Non-Maltreating Mothers.

    Science.gov (United States)

    Skowron, Elizabeth A; Cipriano-Essel, Elizabeth; Benjamin, Lorna Smith; Pincus, Aaron L; Van Ryzin, Mark J

    2013-06-01

    Concurrent and lagged maternal respiratory sinus arrhythmia (RSA) was monitored in the context of parenting. One hundred and forty-one preschooler-mother dyads-involved with child welfare as documented perpetrators of child abuse or neglect, or non-maltreating (non-CM)-were observed completing a resting baseline and joint challenge task. Parenting behaviors were coded using SASB (Benjamin, 1996) and maternal RSA was simultaneously monitored, longitudinally-nested within-person (WP), and subjected to MLM. Abusive and neglectful mothers displayed less positive parenting and more strict/hostile control, relative to non-CM mothers. Non-CM mothers displayed greater WP heterogeneity in variance over time in their RSA scores, and greater consistency over time in their parenting behaviors, relative to abusive or neglectful mothers. CM group also moderated concurrent and lagged WP associations in RSA and positive parenting. When abusive mothers displayed lower RSA in a given epoch, relative to their task average, they showed concurrent increases in positive parenting, and higher subsequent levels of hostile control in the following epoch, suggesting that it is physiologically taxing for abusive mothers to parent in positive ways. In contrast, lagged effects for non-CM mothers were observed in which RSA decreases led to subsequent WP increases in positive parenting and decreases in control. Reversed models were significant only for neglectful mothers: Increases in positive parenting led to subsequent increases in RSA levels, and increases in strict, hostile control led to subsequent RSA decreases. These results provide new evidence that concurrent and time-ordered coupling in maternal physiology and behavior during parenting vary in theoretically meaningful ways across CM and non-CM mothers. Implications for intervention and study limitations are discussed.

  1. 7 CFR 5.1 - Parity index and index of prices received by farmers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Parity index and index of prices received by farmers... § 5.1 Parity index and index of prices received by farmers. (a) The parity index and related indices... farmers, interest, taxes, and farm wage rates, as revised May 1976 and published in the May 28, 1976, and...

  2. Currency Valuation and Purchasing Power Parity

    OpenAIRE

    Jamal Ibrahim Haidar

    2011-01-01

    This paper aims to highlight key limitations of The Economist magazine’s Big Mac Index (BMI). The Economist markets the BMI as a tool to determine valuation of currencies. This paper shows that the BMI is a misleading measure of currency valuation for economies whose markets are structurally different from the benchmark currency countries.

  3. Gestational age, gender and parity specific centile charts for placental weight for singleton deliveries in Aberdeen, UK.

    Science.gov (United States)

    Wallace, J M; Bhattacharya, S; Horgan, G W

    2013-03-01

    The weight of the placenta is a crude but useful proxy for its function in vivo. Accordingly extremes of placental weight are associated with adverse pregnancy outcomes while even normal variations in placental size may impact lifelong health. Centile charts of placental weight for gestational age and gender are used to identify placental weight extremes but none report the effect of parity. Thus the objective was to produce gender and gestational age specific centile charts for placental weight in nulliparous and multiparous women. Data was extracted from the Aberdeen Maternity and Neonatal Databank for all women delivering singleton babies in Aberdeen city and district after 24 weeks gestation. Gestational age specific centile charts for placental weight by gender and parity grouping (n = 88,649 deliveries over a 30 year period) were constructed using the LMS method after exclusion of outliers (0.63% of deliveries meeting study inclusion criteria). Tables and figures are presented for placental weight centiles according to gestational age, gender and parity grouping. Tables are additionally presented for the birth weight to placental weight ratio by gender. Placental weight and the fetal:placental weight ratio were higher in male versus female deliveries. Placental weight was greater in multiparous compared with nulliparous women. We present strong evidence that both gender and parity grouping influence placental weight centiles. The differences at any given gestational age are small and the effects of parity are greater overall than those of gender. In contrast the birth weight to placental weight ratio differs by gender only. These UK population specific centile charts may be useful in studies investigating the role of the placenta in mediating pregnancy outcome and lifelong health. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. Out-of-Pocket and Health Care Spending Changes for Patients Using Orally Administered Anticancer Therapy After Adoption of State Parity Laws.

    Science.gov (United States)

    Dusetzina, Stacie B; Huskamp, Haiden A; Winn, Aaron N; Basch, Ethan; Keating, Nancy L

    2017-11-09

    Oral anticancer medications are increasingly important but costly treatment options for patients with cancer. By early 2017, 43 states and Washington, DC, had passed laws to ensure patients with private insurance enrolled in fully insured health plans pay no more for anticancer medications administered by mouth than anticancer medications administered by infusion. Federal legislation regarding this issue is currently pending. Despite their rapid acceptance, the changes associated with state adoption of oral chemotherapy parity laws have not been described. To estimate changes in oral anticancer medication use, out-of-pocket spending, and health plan spending associated with oral chemotherapy parity law adoption. Analysis of administrative health plan claims data from 2008-2012 for 3 large nationwide insurers aggregated by the Health Care Cost Institute. Data analysis was first completed in 2015 and updated in 2017. The study population included 63 780 adults living in 1 of 16 states that passed parity laws during the study period and who received anticancer drug treatment for which orally administered treatment options were available. Study analysis used a difference-in-differences approach. Time period before and after adoption of state parity laws, controlling for whether the patient was enrolled in a plan subject to parity (fully insured) or not (self-funded, exempt via the Employee Retirement Income Security Act). Oral anticancer medication use, out-of-pocket spending, and total health care spending. Of the 63 780 adults aged 18 through 64 years, 51.4% participated in fully insured plans and 48.6% in self-funded plans (57.2% were women; 76.8% were aged 45 to 64 years). The use of oral anticancer medication treatment as a proportion of all anticancer treatment increased from 18% to 22% (adjusted difference-in-differences risk ratio [aDDRR], 1.04; 95% CI, 0.96-1.13; P = .34) comparing months before vs after parity. In plans subject to parity laws, the

  5. Electron-electron bound states in parity-preserving QED3

    International Nuclear Information System (INIS)

    Belich, H.; Helayel-Neto, J.A.; Centro Brasileiro de Pesquisas Fisicas; Cima, O.M. del; Ferreira Junior, M.M.; Maranhao Univ., Sao Luis, MA

    2002-04-01

    By considering the Higgs mechanism in the framework of a parity-preserving Planar Quantum Electrodynamics, one shows that an attractive electron-electron interaction may dominate. The e - e - interaction potential emerges as the non-relativistic limit of the Moeller scattering amplitude and it results attractive with a suitable choice of parameters. Numerically values of the e - e - binding energy are obtained by solving the two-dimensional Schroedinger equation. The existence of bound states is a strong indicative that this model may be adopted to address the pairing mechanism of high-T c superconductivity. (author)

  6. Electron-electron bound states in parity-preserving QED{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Belich, H.; Helayel-Neto, J.A. [Universidade Catolica do Petropolis, RJ (Brazil). Grupo de Fisica Teorica]|[Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil). Coordenacao de Teoria de Campos e Particulas; Cima, O.M. del [Universidade Catolica do Petropolis, RJ (Brazil). Grupo de Fisica Teorica; Ferreira Junior, M.M. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil). Coordenacao de Teoria de Campos e Particulas]|[Maranhao Univ., Sao Luis, MA (Brazil). Dept. de Fisica

    2002-04-01

    By considering the Higgs mechanism in the framework of a parity-preserving Planar Quantum Electrodynamics, one shows that an attractive electron-electron interaction may dominate. The e{sup -}e{sup -} interaction potential emerges as the non-relativistic limit of the Moeller scattering amplitude and it results attractive with a suitable choice of parameters. Numerically values of the e{sup -}e{sup -} binding energy are obtained by solving the two-dimensional Schroedinger equation. The existence of bound states is a strong indicative that this model may be adopted to address the pairing mechanism of high-T{sub c} superconductivity. (author)

  7. Crosstalk eliminating and low-density parity-check codes for photochromic dual-wavelength storage

    Science.gov (United States)

    Wang, Meicong; Xiong, Jianping; Jian, Jiqi; Jia, Huibo

    2005-01-01

    Multi-wavelength storage is an approach to increase the memory density with the problem of crosstalk to be deal with. We apply Low Density Parity Check (LDPC) codes as error-correcting codes in photochromic dual-wavelength optical storage based on the investigation of LDPC codes in optical data storage. A proper method is applied to reduce the crosstalk and simulation results show that this operation is useful to improve Bit Error Rate (BER) performance. At the same time we can conclude that LDPC codes outperform RS codes in crosstalk channel.

  8. A Resolution of the Purchasing Power Parity Puzzle: Imperfect Knowledge and Long Swings

    DEFF Research Database (Denmark)

    Frydman, Roman; Goldberg, Michael D.; Johansen, Søren

    2009-01-01

    Asset prices undergo long swings that revolve around benchmark levels. In currency markets, fluctuations involve real exchange rates that are highly persistent and that move in near-parallel fashion with nominal rates. The inability to explain these two regularities with one model has been called...... the "purchasing power parity puzzle." In this paper, we trace the puzzle to exchange rate modelers' use of the "Rational Expectations Hypothesis." We show that once imperfect knowledge is recognized, a monetary model is able to account for the puzzle, as well as other salient features of the data, including...

  9. Burgernomics: a big MacT guide to purchasing power parity

    OpenAIRE

    Michael R. Pakko; Patricia S. Pollard

    2003-01-01

    The theory of purchasing power parity (PPP) has long been a staple of international economic analysis. Recent years have seen the rise in popularity of a tongue-in-cheek, fast-food version of PPP: The Big Mac™ index. In this article, Michael Pakko and Patricia Pollard describe how comparisons of Big Mac prices around the world contain the ingredients necessary to demonstrate the fundamental principles of PPP. They show that the Big Mac index does nearly as well as more comprehensive measures ...

  10. Identifying The Purchasing Power Parity of Indonesia Rupiah (IDR) based on BIG MAC Index

    OpenAIRE

    Tongam Sihol Nababan

    2016-01-01

    The aim of this study is to identify : (1) profile of exchange rate and purchasing power parity of IDR against US $ based on Big Mac Index compared to the exchange rate of other countries, and (2) the position of the Big Mac Affordability of Indonesia compared to other ASEAN countries. The results showed that based on Big Mac index during the period April 1998 up to January 2015, IDR exchange rate tends to be undervalued against the USA dollar. The cause of the currency tends to be in a posi...

  11. Validity of Purchasing Power Parity in BRICS under a DFA Approach

    Directory of Open Access Journals (Sweden)

    Emmanuel Numapau Gyamfi

    2017-02-01

    Full Text Available This study tests the validity of the purchasing power parity (PPP theory in Brazil, Russia, India, Macao-China and South Africa. We examine real exchange rates of these countries for mean reversion. The Hurst exponent is our mean reversion measure which is evaluated by the Detrended Fluctuation Analysis (DFA in a rolling window to determine the validity of the PPP theory amongst these countries through time. Our results show persistence in real exchange rates; an indication not supporting the PPP theory in the five countries. The study contributes to the extant literature of the PPP theory in BRICS using the DFA approach in a rolling window through time.

  12. Tunable elastic parity-time symmetric structure based on the shunted piezoelectric materials

    Science.gov (United States)

    Hou, Zhilin; Assouar, Badreddine

    2018-02-01

    We theoretically and numerically report on the tunable elastic Parity-Time (PT) symmetric structure based on shunted piezoelectric units. We show that the elastic loss and gain can be archived in piezoelectric materials when they are shunted by external circuits containing positive and negative resistances. We present and discuss, as an example, the strongly dependent relationship between the exceptional points of a three-layered system and the impedance of their external shunted circuit. The achieved results evidence that the PT symmetric structures based on this proposed concept can actively be tuned without any change of their geometric configurations.

  13. Quantum work relations and response theory in parity-time-symmetric quantum systems

    Science.gov (United States)

    Wei, Bo-Bo

    2018-01-01

    In this work, we show that a universal quantum work relation for a quantum system driven arbitrarily far from equilibrium extends to a parity-time- (PT -) symmetric quantum system with unbroken PT symmetry, which is a consequence of microscopic reversibility. The quantum Jarzynski equality, linear response theory, and Onsager reciprocal relations for the PT -symmetric quantum system are recovered as special cases of the universal quantum work relation in a PT -symmetric quantum system. In the regime of broken PT symmetry, the universal quantum work relation does not hold because the norm is not preserved during the dynamics.

  14. Overview: Parity Violation and Fundamental Symmetries

    Science.gov (United States)

    Carlini, Roger

    2017-09-01

    The fields of nuclear and particle physics have undertaken extensive programs of research to search for evidence of new phenomena via the precision measurement of observables that are well predicted within the standard model of electroweak interaction. It is already known that the standard model is incomplete as it does not include gravity and dark matter/energy and therefore likely the low energy approximation of a more complex theory. This talk will be an overview of the motivation, experimental methods and status of some of these efforts (past and future) related to precision in-direct searches that are complementary to the direct searches underway at the Large Hadron Collider. This abstract is for the invited talk associated with the Mini-symposium titled ``Electro-weak Physics and Fundamental Symmetries'' organized by Julie Roche.

  15. The Uncovered Interest Parity in the Foreign Exchange (FX Markets

    Directory of Open Access Journals (Sweden)

    Silvio Ricardo Micheloto

    2004-12-01

    Full Text Available This work verifies the uncovered interest rates parity (UIP in the FX (foreign exchange emerging markets by using the panel cointegration technique. The data involves several developing countries that compose the EMBI+ Global Index. We compare the results of several panel estimators: OLS (ordinary list square, DOLS (dynamic OLS and FMOLS (fully modified OLS. This new panel technique can handle problems of either non-stationary series (spurious regression or small problem. This latter problem has being considered one of the main causes for distorting the UIP empirical results. By using this approach, we check the UIP in the FX (foreign exchange emerging markets. These markets are more critical because they have been subjected to changing FX regimes and speculative attacks. Our results do not corroborate the uncovered interest parity for the developing countries in the recent years. Thus, the forward premium puzzle may hold in the FX emergent markets.

  16. Combined group ECC protection and subgroup parity protection

    Science.gov (United States)

    Gara, Alan G.; Chen, Dong; Heidelberger, Philip; Ohmacht, Martin

    2013-06-18

    A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit wide vectors with three or more, but an odd number of, elements with value one and the other elements with value zero; and assigning said vectors to rows of the matrix P.

  17. Non-Hermitian photonics based on parity-time symmetry

    Science.gov (United States)

    Feng, Liang; El-Ganainy, Ramy; Ge, Li

    2017-12-01

    Nearly one century after the birth of quantum mechanics, parity-time symmetry is revolutionizing and extending quantum theories to include a unique family of non-Hermitian Hamiltonians. While conceptually striking, experimental demonstration of parity-time symmetry remains unexplored in quantum electronic systems. The flexibility of photonics allows for creating and superposing non-Hermitian eigenstates with ease using optical gain and loss, which makes it an ideal platform to explore various non-Hermitian quantum symmetry paradigms for novel device functionalities. Such explorations that employ classical photonic platforms not only deepen our understanding of fundamental quantum physics but also facilitate technological breakthroughs for photonic applications. Research into non-Hermitian photonics therefore advances and benefits both fields simultaneously.

  18. Evidence of parity violation in 118Sn and 36Cl

    International Nuclear Information System (INIS)

    Benkoula, H.

    1978-01-01

    Parity violation in nuclear systems was studied by forward-backward asymmetry measurement methods in radiative capture of polarized neutrons in the reactions 117 Sn(n,γ) 118 Sn and 35 Cl(n,γ) 36 Cl. The experimental set ups used two INa detectors situated at left and right sides of the beam and parallel to polarisation direction, and an electronic system adapted to high-counting rate. The asymmetry measurement, A=(4.56+-0.6)x10 -4 in the 9.328 MeV Ml transition demonstrates the existence of parity violation effects. The 8.58 MeV (M1+E2) transition in 36 Cl was also studied and the asymmetry value is A=(1.11+-0.35)x10 -4 . Several beam and electronic tests have shown that there was no spurious asymmetry in the measurement due to the equipment [fr

  19. Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine.

    Science.gov (United States)

    Fairweather-Tait, Susan J; Skinner, Jane; Guile, Geoffrey R; Cassidy, Aedín; Spector, Tim D; MacGregor, Alex J

    2011-11-01

    The effect of diet on bone mineral density (BMD) remains controversial, mainly because of difficulties in isolating dietary factors from the confounding influences of age, lifestyle, and genetic factors. The aim of this study was to use a novel method to examine the relation between BMD and diet. A co-twin control study design with linear regression modeling was used to test for associations between BMD and habitual intakes of calcium, vitamin D, protein, and alcohol plus 5 previously identified dietary patterns in postmenopausal women from the TwinsUK registry. This approach exploited the unique matching of twins to provide an estimate of an association that was not confounded by age, genetic background, or shared lifestyle. In >2000 postmenopausal women (BMD data on 1019, 1218, and 1232 twin pairs at the hip neck, hip, and spine, respectively), we observed a positive association between alcohol intake (from wine but not from beer or spirits) and spine BMD (P = 0.01) and a negative association with a traditional 20th-century English diet at the hip neck (P = 0.01). Both associations remained borderline significant after adjustment for mean twin-pair intakes (P = 0.04 and P = 0.055, respectively). Other dietary patterns and intakes of calcium, vitamin D, and protein were unrelated to BMD. Our results showed that diet has an independent but subtle effect on BMD; wine intake was positively associated with spine BMD, whereas a traditional (20th-century) English diet had a negative association with hip BMD.

  20. Status of LHC Searches for SUSY without R-Parity

    International Nuclear Information System (INIS)

    Franceschini, Roberto

    2015-01-01

    In this contribution we briefly review the status of current searches for supersymmetry at the Large Hadron Collider, focusing especially on viable sub-TeV colored superpartners which can appear in nonstandard scenarios. The presented material covers mostly signals that do not crucially rely on the presence of large missing transverse momentum, with special emphasis on R-parity violating supersymmetry. For some scenarios the prospects for the next run of the Large Hadron Collider and future machines are also presented

  1. Measuring parity violation using the neutron capture reaction

    International Nuclear Information System (INIS)

    Frankle, C.M.; Bowman, J.D.; Seestrom, S.J.; Roberson, N.R.; Sharapov, E.I.

    1993-01-01

    Measuring parity violation using the total capture reaction has certain advantages over neutron transmission experiments. Very much less material is required for targets, a necessity when dealing with separated isotopes. The capture reaction is also quite sensitive to very weak resonances. These advantages indicated the need to construct a near 4π gamma ray detector for use at LANSCE. A design for such a detector has been completed. Issues influencing the design and the final design parameters will be discussed in detail

  2. Parity Violation in Atoms and Polarized Electron Scattering

    CERN Document Server

    Bouchiat, Marie-Anne; PAVI'97

    1999-01-01

    This work is an extensive review of the advances in the field of parity violation experiments in electron scattering at high energy and and in atomic physics. The results are a challenge to the standard electroweak theory and the understanding of hadron structure. The theoretical framework is presented at a pedagogical level, experiments and future projects are reviewed, and the results and their interpretation are discussed.

  3. Investigation of the parity forbidden alpha decay of 20Ne

    International Nuclear Information System (INIS)

    Disque, M.

    1978-01-01

    In this thesis the alpha decay of excited states in 20 Ne is investigated. The excited neon states are formed by proton bombardment of 19 F at proton energie of 340 and 670 kev. The ratio E of the parity forbidden alpha decays leading to the ground state of 160 to the allowed decays is determined. The results are E = 7.4 x 10 -5 resonance at 340 kev, E = 4.2 x 10 -3 resonance at 670 kev. (FKS)

  4. Derivation of the parity-violating NN potential

    International Nuclear Information System (INIS)

    Zenkin, S.

    1981-01-01

    The parity-violating NN potential due to vector-meson exchange is considered in the framework of current algebra. A method to calculate the effective P-odd NNV vertex, free of uncertainties due to the existence of the Schwinger and seagull terms, is presented. The final result coincides with the result of the factorization approximation and may be considered as a justification of the approximation

  5. On derivation of the parity-violating internucleon potential

    International Nuclear Information System (INIS)

    Zenkin, S.V.

    1980-01-01

    The parity-violating internucleon potential arising from the vector-meson exchange is considered in the framework of current algebras. An approach free of uncertainties caused by the Schwinger and seagull terms is proposed for the calculation of the effective P-odd NNV vertices. The final result coincides with that of the factorization approximation and may be regarded as a substantiation of the latter

  6. Purchasing power parity: An Application for Turkey (1980-1987)

    OpenAIRE

    Bilge, Cem

    1989-01-01

    Ankara : The Department of Management and the Institute of Management Sciences of Bilkent University, 1989. Thesis (Master's) -- Bilkent University, 1989. Includes bibliographical references leaves 39-42 Purchasing Power Parity (PPP) is claimed to be the oldest and simplest theory in determining the exchange rates of currencies. With its three versions, absolute PPP, relative PPP, and efficient markets PPP, this theory argues that price index levels of the countries are cons...

  7. Reexamination of the Purchasing Power Parity (PPP) under Cournot Competition

    OpenAIRE

    Dai, Meixing

    1995-01-01

    This paper reexamines the Purchasing Power Parity (PPP) in an open economy macroeconomic model with Cournot competition in the international trade of a unique good. Foreign and domestic firms have a Cournot perception of foreign and domestic markets and make separate quantity decisions for each market taking the quantity decisions of the other firm as given. In introducing the money, the balance of payments relation and the nominal exchange rate, the PPP implied by the law of one price can be...

  8. Parity lifetime of bound states in a proximitized semiconductor nanowire

    DEFF Research Database (Denmark)

    Higginbotham, Andrew Patrick; Albrecht, Sven Marian; Kirsanskas, Gediminas

    2015-01-01

    Quasiparticle excitations can compromise the performance of superconducting devices, causing high frequency dissipation, decoherence in Josephson qubits, and braiding errors in proposed Majorana-based topological quantum computers. Quasiparticle dynamics have been studied in detail in metallic...... superconductor layer, yielding an isolated, proximitized nanowire segment. We identify Andreev-like bound states in the semiconductor via bias spectroscopy, determine the characteristic temperatures and magnetic fields for quasiparticle excitations, and extract a parity lifetime (poisoning time) of the bound...

  9. The rho-exchange isovector parity-violating potential

    International Nuclear Information System (INIS)

    McKellar, B.H.J.

    1979-01-01

    It is shown that the rho-exchange isovector parity-violating potential is constrained by PCAC to be much weaker than the π-exchange potential and much weaker than recently proposed by Galic et al (J. Phys. G.; 5: L113 (1979)). This potential does not therefore provide a mechanism for suppressing enhanced neutral-current effects in the π-exchange potential. (author)

  10. Purchasing-Power Parity: Definition, Measurement, and Interpretation

    OpenAIRE

    Robert Lafrance; Lawrence Schembri

    2002-01-01

    This article examines the concept of purchasing-power parity (PPP) and its implications for the equilibrium value of the Canadian exchange rate. PPP has two main applications, as a theory of exchange rate determination and as a means to compare living standards across countries. Concerning exchange rate determination, PPP is mainly useful as a reminder that monetary policy has no long-run impact on the real exchange rate, since the exchange rate can deviate persistently from its PPP value in ...

  11. Parity violation and the masslessness of the neutrino

    International Nuclear Information System (INIS)

    Mannheim, P.D.

    1978-09-01

    It is proposed that the weak interaction be obtained by gauging the strong interaction chiral flavor group. The neutrinos are then four-component spinors. Pairs of right-handed neutrinos are allowed to condense into the vacuum. This produces maximal parity violation in both the quark and lepton sectors of the weak interaction, keeps the neutrinos massless, and also leads to the conventional Weinberg mixing pattern. The approach also in principle provides a way of calculating the Cabibbo angle. 11 references

  12. Parity Violation in Proton-Proton Scattering at Intermediate Energies

    Science.gov (United States)

    Yuan, V.; Frauenfelder, H.; Harper, R. W.; Bowman, J. D.; Carlini, R.; MacArthur, D. W.; Mischke, R. E.; Nagle, D. E.; Talaga, R. L.; McDonald, A. B.

    1986-05-01

    Results of a measurement of parity nonconservation in the anti p-p total cross sections at 800-MeV are presented. The dependence of transmission on beam properties and correction for systematic errors are discussed. The measured longitudinal asymmetry is A{sub L} = (+2.4 +- 1.1(statistical) +- 0.1(systematic)) x 10{sup -7}. A proposed experiment at 230 MeV is discussed.

  13. Parity violation and the masslessness of the neutrino

    Energy Technology Data Exchange (ETDEWEB)

    Mannheim, P.D.

    1978-09-01

    It is proposed that the weak interaction be obtained by gauging the strong interaction chiral flavor group. The neutrinos are then four-component spinors. Pairs of right-handed neutrinos are allowed to condense into the vacuum. This produces maximal parity violation in both the quark and lepton sectors of the weak interaction, keeps the neutrinos massless, and also leads to the conventional Weinberg mixing pattern. The approach also in principle provides a way of calculating the Cabibbo angle. 11 references.

  14. Evidence for parity nonconservation in the weak neutral current

    International Nuclear Information System (INIS)

    Benvenuti, A.; Cline, D.; Messing, F.; Ford, W.; Imlay, R.; Ling, T.Y.; Mann, A.K.; Reeder, D.D.; Rubbia, C.; Stefanski, R.; Sulak, L.; Wanderer, P.

    1976-01-01

    Measurements of R/sup nu/ and R/sup nu-bar/, the ratios of neutral current to charged current ν and nu-bar cross sections, yield neutral current rates for ν and nu-bar that are consistent with a pure V-A interaction but 3 standard deviations from pure V or pure A, indicating the presence of parity nonconservation in the weak neutral current

  15. Parity violation in proton-proton scattering at intermediate energies

    International Nuclear Information System (INIS)

    Yuan, V.; Frauenfelder, H.; Harper, R.W.

    1986-05-01

    Results of a measurement of parity nonconservation in the anti p-p total cross sections at 800-MeV are presented. The dependence of transmission on beam properties and correction for systematic errors are discussed. The measured longitudinal asymmetry is A/sub L/ = (+2.4 +- 1.1(statistical) +- 0.1(systematic)) x 10 -7 . A proposed experiment at 230 MeV is discussed. 16 refs., 1 fig

  16. Combining Ratio Estimation for Low Density Parity Check (LDPC) Coding

    Science.gov (United States)

    Mahmoud, Saad; Hi, Jianjun

    2012-01-01

    The Low Density Parity Check (LDPC) Code decoding algorithm make use of a scaled receive signal derived from maximizing the log-likelihood ratio of the received signal. The scaling factor (often called the combining ratio) in an AWGN channel is a ratio between signal amplitude and noise variance. Accurately estimating this ratio has shown as much as 0.6 dB decoding performance gain. This presentation briefly describes three methods for estimating the combining ratio: a Pilot-Guided estimation method, a Blind estimation method, and a Simulation-Based Look-Up table. The Pilot Guided Estimation method has shown that the maximum likelihood estimates of signal amplitude is the mean inner product of the received sequence and the known sequence, the attached synchronization marker (ASM) , and signal variance is the difference of the mean of the squared received sequence and the square of the signal amplitude. This method has the advantage of simplicity at the expense of latency since several frames worth of ASMs. The Blind estimation method s maximum likelihood estimator is the average of the product of the received signal with the hyperbolic tangent of the product combining ratio and the received signal. The root of this equation can be determined by an iterative binary search between 0 and 1 after normalizing the received sequence. This method has the benefit of requiring one frame of data to estimate the combining ratio which is good for faster changing channels compared to the previous method, however it is computationally expensive. The final method uses a look-up table based on prior simulated results to determine signal amplitude and noise variance. In this method the received mean signal strength is controlled to a constant soft decision value. The magnitude of the deviation is averaged over a predetermined number of samples. This value is referenced in a look up table to determine the combining ratio that prior simulation associated with the average magnitude of

  17. Dynamical matter-parity breaking and gravitino dark matter

    International Nuclear Information System (INIS)

    Schmidt, Jonas; Weniger, Christoph; Yanagida, Tsutomu T.; Tokyo Univ.

    2010-10-01

    Scenarios where gravitinos with GeV masses make up dark matter are known to be in tension with high reheating temperatures, as required by e.g. thermal leptogenesis. This tension comes from the longevity of the NLSPs, which can destroy the successful predictions of the standard primordial nucleosynthesis. However, a small violation of matter parity can open new decay channels for the NLSP, avoiding the BBN problems, while being compatible with experimental cosmic-ray constraints. In this paper, we propose a model where matter parity, which we assume to be embedded in the U(1) B-L gauge symmetry, is broken dynamically in a hidden sector at low scales. This can naturally explain the smallness of the matter parity breaking in the visible sector. We discuss the dynamics of the corresponding pseudo Nambu-Goldstone modes of B-L breaking in the hidden sector, and we comment on typical cosmic-ray and collider signatures in our model. (orig.)

  18. Towards improved measurements of parity violation in atomic ytterbium

    Energy Technology Data Exchange (ETDEWEB)

    Antypas, D., E-mail: dantypas@uni-mainz.de [Helmholtz-Institut Mainz (Germany); Fabricant, A.; Bougas, L. [Johannes Gutenberg-Universität Mainz, Institut für Physik (Germany); Tsigutkin, K. [ASML (Netherlands); Budker, D. [Helmholtz-Institut Mainz (Germany)

    2017-11-15

    We report on progress towards performing precision measurements of parity violation in Yb, in which the theoretical prediction for a strong weak-interaction-induced effect in the 6s{sup 2} {sup 1}S{sub 0}→ 5d6s{sup 3}D{sub 1} optical transition at 408 nm has already been confirmed, with a measurement of the effect at the ≈10 % level of accuracy. With a new atomic-beam apparatus offering enhanced sensitivity, we are aiming at precisely determining the parity violation observable in Yb, which will allow us to probe the distributions of neutrons in different isotopes, investigate physics beyond the Standard Model, as well as to study intra-nucleus weak interactions, through an observation of the anapole moment of Yb nuclei with nonzero spin. We present the experimental principle employed to probe atomic parity violation, describe our new apparatus, and discuss the attained experimental sensitivity as well as the methods for characterizing systematics in these measurements.

  19. Axial and parity anomalies and vacuum charge: A direct approach

    International Nuclear Information System (INIS)

    Boyanovsky, D.; Blankenbecler, R.

    1985-01-01

    We study the axial and parity anomalies in Abelian gauge theories using the direct yet intuitive approach of counting the relative number of states of one chirality with respect to the other. A fundamental gauge-invariant quantity, the determinantal ratio, is introduced for this purpose. We find that the number of states is conserved and that the gauge fields differentially phase shift states of opposite chirality at infinite energies. This implies a relative flow of states at very large energies which must be compensated by a rearrangement of the density of states at finite energies. We then derive a sum rule which yields two alternative formulas for the index of a Dirac operator. One expresses the index in terms of its high-energy behavior, and the other in terms of the low-energy properties; these are the ''zero modes'' of definite chirality. Two examples are worked out in detail to clarify our general result. The physics of the axial anomaly is shown to translate into that of the parity anomaly in 2+1 dimensions, in which parity and chirality have interchanged roles. We also analyze the vacuum charge in regard to its high- and low-energy origin. The possibility of spectral flow is formulated and briefly discussed. In short, we provide a physical interpretation of certain mathematical indices, relate them to an extended version of Levinson's theorem of potential scattering, and simplify their evaluation

  20. Parity Bit Replenishment for JPEG 2000-Based Video Streaming

    Directory of Open Access Journals (Sweden)

    François-Olivier Devaux

    2009-01-01

    Full Text Available This paper envisions coding with side information to design a highly scalable video codec. To achieve fine-grained scalability in terms of resolution, quality, and spatial access as well as temporal access to individual frames, the JPEG 2000 coding algorithm has been considered as the reference algorithm to encode INTRA information, and coding with side information has been envisioned to refresh the blocks that change between two consecutive images of a video sequence. One advantage of coding with side information compared to conventional closed-loop hybrid video coding schemes lies in the fact that parity bits are designed to correct stochastic errors and not to encode deterministic prediction errors. This enables the codec to support some desynchronization between the encoder and the decoder, which is particularly helpful to adapt on the fly pre-encoded content to fluctuating network resources and/or user preferences in terms of regions of interest. Regarding the coding scheme itself, to preserve both quality scalability and compliance to the JPEG 2000 wavelet representation, a particular attention has been devoted to the definition of a practical coding framework able to exploit not only the temporal but also spatial correlation among wavelet subbands coefficients, while computing the parity bits on subsets of wavelet bit-planes. Simulations have shown that compared to pure INTRA-based conditional replenishment solutions, the addition of the parity bits option decreases the transmission cost in terms of bandwidth, while preserving access flexibility.

  1. Neural redundancy applied to the parity space for signal validation

    International Nuclear Information System (INIS)

    Mol, Antonio Carlos de Abreu; Pereira, Claudio Marcio Nascimento Abreu; Martinez, Aquilino Senra

    2005-01-01

    The objective of signal validation is to provide more reliable information from the plant sensor data The method presented in this work introduces the concept of neural redundancy and applies it to the space parity method [1] to overcome an inherent deficiency of this method - the determination of the best estimative of the redundant measures when they are inconsistent. The concept of neural redundancy consists on the calculation of a redundancy through neural networks based on the time series of the own state variable. Therefore, neural networks, dynamically trained with the time series, will estimate the current value of the own measure, which will be used as referee of the redundant measures in the parity space. For this purpose the neural network should have the capacity to supply the neural redundancy in real time and with maximum error corresponding to the group deviation. The historical series should be enough to allow the estimate of the next value, during transients and at the same time, it should be optimized to facilitate the retraining of the neural network to each acquisition. In order to have the capacity to reproduce the tendency of the time series even under accident condition, the dynamic training of the neural network privileges the recent points of the time series. The tests accomplished with simulated data of a nuclear plant, demonstrated that this method applied on the parity space method improves the signal validation process. (author)

  2. Neural redundancy applied to the parity space for signal validation

    Energy Technology Data Exchange (ETDEWEB)

    Mol, Antonio Carlos de Abreu; Pereira, Claudio Marcio Nascimento Abreu [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil)]. E-mail: cmnap@ien.gov.br; Martinez, Aquilino Senra [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia]. E-mail: aquilino@lmp.br

    2005-07-01

    The objective of signal validation is to provide more reliable information from the plant sensor data The method presented in this work introduces the concept of neural redundancy and applies it to the space parity method [1] to overcome an inherent deficiency of this method - the determination of the best estimative of the redundant measures when they are inconsistent. The concept of neural redundancy consists on the calculation of a redundancy through neural networks based on the time series of the own state variable. Therefore, neural networks, dynamically trained with the time series, will estimate the current value of the own measure, which will be used as referee of the redundant measures in the parity space. For this purpose the neural network should have the capacity to supply the neural redundancy in real time and with maximum error corresponding to the group deviation. The historical series should be enough to allow the estimate of the next value, during transients and at the same time, it should be optimized to facilitate the retraining of the neural network to each acquisition. In order to have the capacity to reproduce the tendency of the time series even under accident condition, the dynamic training of the neural network privileges the recent points of the time series. The tests accomplished with simulated data of a nuclear plant, demonstrated that this method applied on the parity space method improves the signal validation process. (author)

  3. Search for local parity violation with STAR ZDC-SMD

    Energy Technology Data Exchange (ETDEWEB)

    Wang Gang, E-mail: gwang@physics.ucla.ed [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States)

    2010-06-01

    Parity-odd domains are predicted to lead to charge separation of quarks along the orbital momentum of the system created in non-central relativistic heavy ion collisions. A signal consistent with several of the theoretical expectations has been detected by STAR, with a three particle azimuthal correlator which is a P-even observable, but still sensitive to the charge separation effect. In this correlator, the first two particles are used to reveal the physics of interest, and the third particle serves as a reference for the reaction plane. In this work, to minimize the non-parity correlation between the third particle and the first two, we utilize the spectator neutrons detected by STAR ZDC-SMDs to define the event plane. The 1st-order event plane thus obtained can also be used to study the global strong parity violation effect, and to provide further systematic checks for this analysis. We report measurements of both P-even and P-odd observables using the STAR ZDC-SMDs in Au+Au at 200 GeV. The results are presented as a function of collision centrality, particle separation in rapidity and transverse momentum (p{sub T}). Systematic checks on the impact from the directed flow will also be discussed.

  4. Dynamical matter-parity breaking and gravitino dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jonas; Weniger, Christoph [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Tokyo Univ. (JP). Inst. for the Physics and Mathematics of the Universe (IPMU); Yanagida, Tsutomu T. [Tokyo Univ. (JP). Inst. for the Physics and Mathematics of the Universe (IPMU); Tokyo Univ. (Japan). Dept. of Physics

    2010-10-15

    Scenarios where gravitinos with GeV masses make up dark matter are known to be in tension with high reheating temperatures, as required by e.g. thermal leptogenesis. This tension comes from the longevity of the NLSPs, which can destroy the successful predictions of the standard primordial nucleosynthesis. However, a small violation of matter parity can open new decay channels for the NLSP, avoiding the BBN problems, while being compatible with experimental cosmic-ray constraints. In this paper, we propose a model where matter parity, which we assume to be embedded in the U(1){sub B-L} gauge symmetry, is broken dynamically in a hidden sector at low scales. This can naturally explain the smallness of the matter parity breaking in the visible sector. We discuss the dynamics of the corresponding pseudo Nambu-Goldstone modes of B-L breaking in the hidden sector, and we comment on typical cosmic-ray and collider signatures in our model. (orig.)

  5. Encoding of QC-LDPC Codes of Rank Deficient Parity Matrix

    Directory of Open Access Journals (Sweden)

    Mohammed Kasim Mohammed Al-Haddad

    2016-05-01

    Full Text Available the encoding of long low density parity check (LDPC codes presents a challenge compared to its decoding. The Quasi Cyclic (QC LDPC codes offer the advantage for reducing the complexity for both encoding and decoding due to its QC structure. Most QC-LDPC codes have rank deficient parity matrix and this introduces extra complexity over the codes with full rank parity matrix. In this paper an encoding scheme of QC-LDPC codes is presented that is suitable for codes with full rank parity matrix and rank deficient parity matrx. The extra effort required by the codes with rank deficient parity matrix over the codes of full rank parity matrix is investigated.

  6. Atomic Parity Violation Overview and Perspectives

    CERN Document Server

    CERN. Geneva. Audiovisual Unit

    2002-01-01

    Optical experiments have demonstrated cases in which mirror symmetry in stable atoms is broken during absorption or emission of light. Such results are in conflict with standard electromagnetic (EM) theory, but can be explained within the unified electroweak theory. Their interpretation is based on exchanges of virtual weak neutral Z_0 bosons between the electrons and the atomic nucleus. These effects were predicted to increase in heavy atoms a little faster than the cube of the atomic number. Moreover, in a highly forbidden transition, like the 6S-7S transition in cesium, the EM interaction is suppressed, leaving the Z_0 exchange a chance to show up. For achieving the determination of the Cs nucleus weak charge, Q_W(Cs), the basic experimental parameter playing in Z_0, exchange the same role as the nuclear charge in the Coulomb interaction, both experimental and theoretical hurdles had to be overcome: first, the excitation and detection of an atomic line with a transition rate about 10^{14} times less than a...

  7. National data showed that delayed sleep in six-year-old children was associated with excessive use of electronic devices at 12 years.

    Science.gov (United States)

    Kato, Tsuguhiko; Yorifuji, Takashi; Yamakawa, Michiyo; Inoue, Sachiko

    2018-01-31

    Cross-sectional studies have shown associations between adolescent sleep problems and the use of electronic devices, such as mobile phones, but longitudinal studies remain scarce. We explored any association between delayed bedtimes at six years old and the excessive use of electronic devices at 12 years of age. Texting was a prime focus. We analysed 9607 adolescents who owned mobile phones in 2013 using the Japanese Longitudinal Survey of Newborns in the 21st Century, which started in 2001. The outcomes were daily excessive use of a mobile phone, television (TV) and video games. Delayed bedtime at the age of six years was associated with excessive texting at weekends. The adjusted odds ratios and 95% confidence intervals obtained from logistic regression analyses were 1.88 (1.14-3.10) for the 10-11 pm group and 1.98 (1.08-3.63) for the after 11 pm group, compared with the before 9 pm group. Later bedtimes were also associated with increased risks of excessive TV viewing and video game use. Our study indicated that six-year-olds who regularly stayed up late at night used electronic devices more frequently, or for longer, at the age of 12. Parents need to be more aware of links between sleep issues and electronic devices. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  8. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

    DEFF Research Database (Denmark)

    Andreassen, Christian Nicolaj; Rosenstein, Barry S; Kerns, Sarah L

    2016-01-01

    PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried ou...

  9. Dairy shows different associations with abdominal and BMI-defined overweight: cross-sectional analyses exploring a variety of dairy products

    NARCIS (Netherlands)

    Brouwer, E.M.; Sluik, D.; Singh-Povel, C.M.; Feskens, E.J.M.

    2018-01-01

    Background and aims: Previous studies suggest weight-regulatory properties for several dairy nutrients, but population-based studies on dairy and body weight are inconclusive. We explored cross-sectional associations between dairy consumption and indicators of overweight. Methods and results: We

  10. Bronchus-associated lymphoid tissue (BALT) lymphoma of the lung showing mosaic pattern of inhomogeneous attenuation on thin-section CT: a case report

    International Nuclear Information System (INIS)

    Lee, In Jae; Kim, Sung Hwan; Koo, Soo Hyun; Kim, Hyun Beom; Hwang, Dae Hyun; Lee, Kwan Seop; Lee, Yul; Jang, Kee Taek; Kim, Duck Hwan

    2000-01-01

    The authors present a case of histologically proven bronchus-associated lymphoid tissue (BALT) lymphoma of the lung in a patient with primary Sjogren's syndrome that manifested on thin-section CT scan as a mosaic pattern of inhomogeneous attenuation due to mixed small airway and infiltrative abnormalities

  11. Bronchus-associated lymphoid tissue (BALT) lymphoma of the lung showing mosaic pattern of inhomogeneous attenuation on thin-section CT: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, In Jae; Kim, Sung Hwan; Koo, Soo Hyun; Kim, Hyun Beom; Hwang, Dae Hyun; Lee, Kwan Seop; Lee, Yul; Jang, Kee Taek; Kim, Duck Hwan [Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

    2000-09-01

    The authors present a case of histologically proven bronchus-associated lymphoid tissue (BALT) lymphoma of the lung in a patient with primary Sjogren's syndrome that manifested on thin-section CT scan as a mosaic pattern of inhomogeneous attenuation due to mixed small airway and infiltrative abnormalities.

  12. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

    NARCIS (Netherlands)

    Randall, Joshua C.; Winkler, Thomas W.; Kutalik, Zoltán; Berndt, Sonja I.; Jackson, Anne U.; Monda, Keri L.; Kilpeläinen, Tuomas O.; Esko, Tõnu; Mägi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; Feitosa, Mary F.; Croteau-Chonka, Damien C.; Day, Felix R.; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; Locke, Adam E.; Mathieson, Iain; Scherag, Andre; Vedantam, Sailaja; Wood, Andrew R.; Liang, Liming; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Dermitzakis, Emmanouil T.; Dimas, Antigone S.; Karpe, Fredrik; Min, Josine L.; Nicholson, George; Clegg, Deborah J.; Person, Thomas; Krohn, Jon P.; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amélie; Froguel, Philippe; Hottenga, Jouke-Jan; Prokopenko, Inga; Waite, Lindsay L.; Harris, Tamara B.; Smith, Albert Vernon; Shuldiner, Alan R.; McArdle, Wendy L.; Caulfield, Mark J.; Munroe, Patricia B.; Grönberg, Henrik; Chen, Yii-Der Ida; Li, Guo; Beckmann, Jacques S.; Johnson, Toby; Thorsteinsdottir, Unnur; Teder-Laving, Maris; Khaw, Kay-Tee; Wareham, Nicholas J.; Zhao, Jing Hua; Amin, Najaf; Oostra, Ben A.; Kraja, Aldi T.; Province, Michael A.; Cupples, L. Adrienne; Heard-Costa, Nancy L.; Kaprio, Jaakko; Ripatti, Samuli; Surakka, Ida; Collins, Francis S.; Saramies, Jouko; Tuomilehto, Jaakko; Jula, Antti; Salomaa, Veikko; Erdmann, Jeanette; Hengstenberg, Christian; Loley, Christina; Schunkert, Heribert; Lamina, Claudia; Wichmann, H. Erich; Albrecht, Eva; Gieger, Christian; Hicks, Andrew A.; Johansson, Asa; Pramstaller, Peter P.; Kathiresan, Sekar; Speliotes, Elizabeth K.; Penninx, Brenda; Hartikainen, Anna-Liisa; Jarvelin, Marjo-Riitta; Gyllensten, Ulf; Boomsma, Dorret I.; Campbell, Harry; Wilson, James F.; Chanock, Stephen J.; Farrall, Martin; Goel, Anuj; Medina-Gomez, Carolina; Rivadeneira, Fernando; Estrada, Karol; Uitterlinden, André G.; Hofman, Albert; Zillikens, M. Carola; den Heijer, Martin; Kiemeney, Lambertus A.; Maschio, Andrea; Hall, Per; Tyrer, Jonathan; Teumer, Alexander; Völzke, Henry; Kovacs, Peter; Tönjes, Anke; Mangino, Massimo; Spector, Tim D.; Hayward, Caroline; Rudan, Igor; Hall, Alistair S.; Samani, Nilesh J.; Attwood, Antony Paul; Sambrook, Jennifer G.; Hung, Joseph; Palmer, Lyle J.; Lokki, Marja-Liisa; Sinisalo, Juha; Boucher, Gabrielle; Huikuri, Heikki; Lorentzon, Mattias; Ohlsson, Claes; Eklund, Niina; Eriksson, Johan G.; Barlassina, Cristina; Rivolta, Carlo; Nolte, Ilja M.; Snieder, Harold; van der Klauw, Melanie M.; van Vliet-Ostaptchouk, Jana V.; Gejman, Pablo V.; Shi, Jianxin; Jacobs, Kevin B.; Wang, Zhaoming; Bakker, Stephan J. L.; Mateo Leach, Irene; Navis, Gerjan; van der Harst, Pim; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Yang, Jian; Chasman, Daniel I.; Ridker, Paul M.; Rose, Lynda M.; Lehtimäki, Terho; Raitakari, Olli; Absher, Devin; Iribarren, Carlos; Basart, Hanneke; Hovingh, Kees G.; Hyppönen, Elina; Power, Chris; Anderson, Denise; Beilby, John P.; Hui, Jennie; Jolley, Jennifer; Sager, Hendrik; Bornstein, Stefan R.; Schwarz, Peter E. H.; Kristiansson, Kati; Perola, Markus; Lindström, Jaana; Swift, Amy J.; Uusitupa, Matti; Atalay, Mustafa; Lakka, Timo A.; Rauramaa, Rainer; Bolton, Jennifer L.; Fowkes, Gerry; Fraser, Ross M.; Price, Jackie F.; Fischer, Krista; Krjutå Kov, Kaarel; Metspalu, Andres; Mihailov, Evelin; Langenberg, Claudia; Luan, Jian'an; Ong, Ken K.; Chines, Peter S.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Edkins, Sarah; Franks, Paul W.; Hallmans, Göran; Shungin, Dmitry; Morris, Andrew David; Palmer, Colin N. A.; Erbel, Raimund; Moebus, Susanne; Nöthen, Markus M.; Pechlivanis, Sonali; Hveem, Kristian; Narisu, Narisu; Hamsten, Anders; Humphries, Steve E.; Strawbridge, Rona J.; Tremoli, Elena; Grallert, Harald; Thorand, Barbara; Illig, Thomas; Koenig, Wolfgang; Müller-Nurasyid, Martina; Peters, Annette; Boehm, Bernhard O.; Kleber, Marcus E.; März, Winfried; Winkelmann, Bernhard R.; Kuusisto, Johanna; Laakso, Markku; Arveiler, Dominique; Cesana, Giancarlo; Kuulasmaa, Kari; Virtamo, Jarmo; Yarnell, John W. G.; Kuh, Diana; Wong, Andrew; Lind, Lars; de Faire, Ulf; Gigante, Bruna; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Dedoussis, George; Dimitriou, Maria; Kolovou, Genovefa; Kanoni, Stavroula; Stirrups, Kathleen; Bonnycastle, Lori L.; Njølstad, Inger; Wilsgaard, Tom; Ganna, Andrea; Rehnberg, Emil; Hingorani, Aroon; Kivimaki, Mika; Kumari, Meena; Assimes, Themistocles L.; Barroso, Inês; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Frayling, Timothy; Groop, Leif C.; Haritunians, Talin; Hunter, David; Ingelsson, Erik; Kaplan, Robert; Mohlke, Karen L.; O'Connell, Jeffrey R.; Schlessinger, David; Strachan, David P.; Stefansson, Kari; van Duijn, Cornelia M.; Abecasis, Gonçalo R.; McCarthy, Mark I.; Hirschhorn, Joel N.; Qi, Lu; Loos, Ruth J. F.; Lindgren, Cecilia M.; North, Kari E.; Heid, Iris M.

    2013-01-01

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723

  13. Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

    NARCIS (Netherlands)

    Y. Hamdi (Yosr); Soucy, P. (Penny); Adoue, V. (Véronique); K. Michailidou (Kyriaki); S. Canisius (Sander); Lemaçon, A. (Audrey); A. Droit (Arnaud); I.L. Andrulis (Irene); H. Anton-Culver (Hoda); Arndt, V. (Volker); Baynes, C. (Caroline); C. Blomqvist (Carl); N.V. Bogdanova (Natalia); S.E. Bojesen (Stig); M.K. Bolla (Manjeet K.); B. Bonnani (Bernardo); A.-L. Borresen-Dale (Anne-Lise); J.S. Brand (Judith S.); H. Brauch (Hiltrud); Brenner, H. (Hermann); A. Broeks (Annegien); B. Burwinkel (Barbara); J. Chang-Claude (Jenny); Couch, F.J. (Fergus J.); A. Cox (Angela); S.S. Cross (Simon); K. Czene (Kamila); H. Darabi (Hatef); J. Dennis (Joe); P. Devilee (Peter); T. Dörk (Thilo); I. dos Santos Silva (Isabel); M. Eriksson (Mats); P.A. Fasching (Peter); J.D. Figueroa (Jonine); H. Flyger (Henrik); M. García-Closas (Montserrat); Giles, G.G. (Graham G.); M.S. Goldberg (Mark); A. González-Neira (Anna); G. Grenaker Alnæs (Grethe); P. Guénel (Pascal); L. Haeberle (Lothar); C.A. Haiman (Christopher); U. Hamann (Ute); Hallberg, E. (Emily); M.J. Hooning (Maartje); J.L. Hopper (John); A. Jakubowska (Anna); M. Jones (Michael); M. Kabisch (Maria); V. Kataja (Vesa); Lambrechts, D. (Diether); L. Le Marchand (Loic); A. Lindblom (Annika); J. Lubinski (Jan); A. Mannermaa (Arto); M. Maranian (Melanie); S. Margolin (Sara); Marme, F. (Frederik); R.L. Milne (Roger); S.L. Neuhausen (Susan); H. Nevanlinna (Heli); P. Neven (Patrick); C. Olswold (Curtis); J. Peto (Julian); Plaseska-Karanfilska, D. (Dijana); K. Pykäs (Katri); P. Radice (Paolo); A. Rudolph (Anja); E.J. Sawyer (Elinor); M.K. Schmidt (Marjanka); X.-O. Shu (Xiao-Ou); M.C. Southey (Melissa); A.J. Swerdlow (Anthony ); R.A.E.M. Tollenaar (Rob); I.P. Tomlinson (Ian); D. Torres (Diana); T. Truong (Thérèse); C. Vachon (Celine); A.M.W. van den Ouweland (Ans); Q. Wang (Qin); R. Winqvist (Robert); W. Zheng (Wei); J. Benítez (Javier); G. Chenevix-Trench (Georgia); A.M. Dunning (Alison); P.D.P. Pharoah (Paul); Kristensen, V. (Vessela); P. Hall (Per); D.F. Easton (Douglas); T. Pastinen (Tomi); S. Nord (Silje); J. Simard (Jacques)

    2016-01-01

    textabstractThere are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with differential allelic expression are

  14. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    DEFF Research Database (Denmark)

    Randall, Joshua C; Winkler, Thomas W; Kutalik, Zoltán

    2013-01-01

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133...

  15. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    NARCIS (Netherlands)

    Randall, J.C.; Winkler, T.W.; Kutalik, Z.; Berndt, S.I.; Jackson, A.U.; Monda, K.L.; Kilpelainen, T.O.; Esko, T.; Magi, R.; Li, S.; Workalemahu, T.; Feitosa, M.F.; Croteau-Chonka, D.C.; Day, F.R.; Fall, T.; Ferreira, T.; Gustafsson, S.; Locke, A.E.; Mathieson, I.; Scherag, A.; Vedantam, S.; Wood, A.R.; Liang, L.; Steinthorsdottir, V.; Thorleifsson, G.; Dermitzakis, E.T.; Dimas, A.S.; Karpe, F.; Min, J.L.; Nicholson, G.; Clegg, D.J.; Person, T.; Krohn, J.P.; Bauer, S.; Buechler, C.; Eisinger, K.; Bonnefond, A.; Froguel, P.; Hottenga, J.J.; Prokopenko, I.; Waite, L.L.; Harris, T.B.; Smith, A.V.; Shuldiner, A.R.; McArdle, W.L.; Caulfield, M.J.; Munroe, P.B.; Gronberg, H.; Chen, Y.D.; Li, G.; Beckmann, J.S.; Johnson, T.; Thorsteinsdottir, U.; Teder-Laving, M.; Khaw, K.T.; Wareham, N.J.; Zhao, J.H.; Amin, N.; Oostra, B.A.; Kraja, A.T.; Province, M.A.; Cupples, L.A.; Heard-Costa, N.L.; Kaprio, J.; Ripatti, S.; Surakka, I.; Collins, F.S.; Saramies, J.; Tuomilehto, J.; Jula, A.; Salomaa, V.; Erdmann, J.; Hengstenberg, C.; Loley, C.; Schunkert, H.; Lamina, C.; Wichmann, H.E.; Albrecht, E.; Gieger, C.; Hicks, A.A.; Johansson, A; Pramstaller, P.P.; Kathiresan, S.; Speliotes, E.K.; Penninx, B.; Hartikainen, A.L.; Jarvelin, M.R.; Gyllensten, U.; Boomsma, D.I.; Campbell, H.; Wilson, J.F.; Chanock, S.J.; Farrall, M.; Goel, A.; Medina-Gomez, C.; Rivadeneira, F.; Estrada, K.; Uitterlinden, A.G.; Heijer, M. den; Kiemeney, L.A.L.M.; et al.,

    2013-01-01

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723

  16. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

    NARCIS (Netherlands)

    Randall, Joshua C; Winkler, Thomas W; Kutalik, Zoltán; Berndt, Sonja I; Jackson, Anne U; Monda, Keri L; Kilpeläinen, Tuomas O; Esko, Tõnu; Mägi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; Feitosa, Mary F; Croteau-Chonka, Damien C; Day, Felix R; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; Locke, Adam E; Mathieson, Iain; Scherag, Andre; Vedantam, Sailaja; Wood, Andrew R; Liang, Liming; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Dermitzakis, Emmanouil T; Dimas, Antigone S; Karpe, Fredrik; Min, Josine L; Nicholson, George; Clegg, Deborah J; Person, Thomas; Krohn, Jon P; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amélie; Froguel, Philippe; Smith, Albert Vernon; Zhao, Jing Hua; Penninx, Brenda; Nolte, Ilja M; Snieder, Harold; Van der Klauw, Melanie M; Van Vliet-Ostaptchouk, Jana V; Bakker, Stephan J L; Mateo Leach, Irene; Navis, Gerjan; van der Harst, Pim; Kumari, Meena

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723

  17. Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Lindblad Ulf

    2009-06-01

    Full Text Available Abstract Background Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population. Methods In 2001–2004, 1811 men and women (30–75 years were randomly selected from the Vara population, south-western Sweden (81% participation rate. Of these, 1671 subjects with full information on basal morning and evening salivary cortisol and anthropometric measurements were included in this cross-sectional study. Differences between groups were examined by general linear model and by logistic and linear regression analyses. Results Morning and Δ-cortisol (morning – evening cortisol were significantly higher in women than men. In both genders older age was significantly associated with higher levels of all cortisol measures, however, most consistently with evening cortisol. In women only, age-adjusted means of WHR were significantly lower in the highest compared to the lowest quartile of morning cortisol (p = 0.036 and Δ-cortisol (p Conclusion In summary, our findings of generally higher cortisol levels in women than men of all ages are novel and the stronger results seen for Δ-cortisol as opposed to morning cortisol in the association with WHR emphasise the need of studying cortisol variation intra-individually. To our knowledge, the associations in this study have never before been investigated in such a large population sample of both men and women. Our results therefore offer important knowledge on the descriptive characteristics of cortisol in relation to age and gender, and on the impact that associations previously seen between cortisol and abdominal obesity in smaller, selected samples have on a population level.

  18. An evaluation of the effect of parity and age on malaria parasitaemia in pregnancy.

    Science.gov (United States)

    Nnaji, G A; Okafor, C I; Ikechebelu, J I

    2006-11-01

    A higher prevalence of malaria infection (peripheral or placental) has been reported in the primigravidae and secondigravidae when compared with multigravidae. This study set out to determine the effect of parity and age on the prevalence of malaria parasitaemia in pregnancy at the booking antenatal visit at the Nnamdi Azikiwe University Teaching Hospital, Nnewi. Peripheral blood smears were examined in 420 pregnant women at their booking antenatal visit and in 200 control subjects attending the outpatient clinic on the same day for malaria parasites. These subjects (pregnant women and controls) met the inclusion criteria of being HIV sero-negative, not sickle-cell positive, did not have a history of recent blood transfusion and had been resident in Nnewi for 1 year. The result showed that there was a statistically significant difference between the prevalence rate of malaria parasitaemia in the primigravidae (87.9%: 109 of 124) and grand multigravidae (63.6%: 28 of 44); and the rates were found to decrease with increasing parity. The primigravidae had a higher mean parasite density (2,155/micro l) when compared with the multigravidae (1,950/micro l). This study also revealed that pregnant women <20 years had the highest prevalence rate of 86.4% (19 of 22). This study demonstrates the higher prevalence of malaria parasitaemia in pregnant women of lower parity, i.e. primigravidae and secondigravidae. Therefore, targeting malaria control efforts to women in their first and second pregnancy will be an important strategy to reach most infected women and minimise resource expenditure. These women should be motivated to use insecticide treated bed nets (ITBN) and other personal malarial control measures during pregnancy.

  19. Past smoking and current dopamine agonist use show an independent and dose-dependent association with impulse control disorders in Parkinson's disease.

    Science.gov (United States)

    Valença, Guilherme T; Glass, Philip G; Negreiros, Nadja N; Duarte, Meirelayne B; Ventura, Lais M G B; Mueller, Mila; Oliveira-Filho, Jamary

    2013-07-01

    Previous studies have described the association between dopamine replacement therapy in Parkinson's disease and impulse control disorders. A case-control study was performed to establish the prevalence of four of these behaviors in Brazilian patients with Parkinson's disease on stable dopamine replacement therapy and the possible associated risk factors. We investigated 152 patients and 212 healthy controls for pathological gambling, compulsive sexual behavior and compulsive buying and eating. Overall, patients had more impulsive control disorders than controls (18.4% vs. 4.2%, P Impulse control disorders were more common in younger patients (P = 0.008) and in those taking dopamine agonist (P impulse control disorders were history of smoking (odds ratio = 1.059 for each year of smoking, P = 0.010) and current use of pramipexole (odds ratio = 2.551 for each increase in 1 mg, P impulse control disorders in a dose-dependent manner. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population.

    Science.gov (United States)

    Orozco, Ana C; Muñoz, Angélica M; Velásquez, Claudia M; Uscátegui, Rosa M; Parra, María V; Patiño, Fredy A; Manjarrés, Luz M; Parra, Beatriz E; Estrada, Alejandro; Agudelo, Gloria M

    2014-01-01

    Introduction : Obesity results from interaction between genetic and environmental risk factors. To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population. A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms ( UCP3- rs1800849, FTO -rs17817449, and CAPN10 -rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet. A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10 ) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals. In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.

  1. Women show a closer association between educational level and hypertension or diabetes mellitus than males: a secondary analysis from the Austrian HIS

    Directory of Open Access Journals (Sweden)

    Kautzky-Willer Alexandra

    2012-05-01

    Full Text Available Abstract Background Lifestyle diseases and cardiovascular complications are dramatically increasing, but little is known about the impact of educational level and health behaviour in men and women in different populations. Therefore, we aimed to investigate the association between educational level (EL and self-reported chronic diseases and health behaviour in both sexes. Methods Data were derived from the Austrian Health Interview Surveys 2006/2007, which includes 13 558 persons (50.9% females. The associations between EL and the risk of obesity, hypertension, diabetes, myocardial infarction, stroke and anxiety disorders or depression, nutrition, exercise, and smoking were evaluated. University education served as the reference category (EL4, the lowest educational level was required schooling only (EL0. Results Only among women did the risk for diabetes mellitus and hypertension increase with decreasing educational level with the highest rates for EL0 OR [95% CI] adjusted for age, income, family status and lifestyle: 3.7 [1.7-8.0], and 2.5 [1.8-3.5], respectively. Only among the men, however, did the risk for stroke increase with decreasing educational level adjusted OR for EL0: 8.5 [1.7-42.7]. For anthropometric measures and lifestyle factors in both sexes the risk increased with decreasing EL. Conclusion EL affects lifestyle, overweight and obesity in both sexes. The apparent sex-specific differences in the association between the prevalence of some chronic disease with EL call for further investigation.

  2. TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study

    International Nuclear Information System (INIS)

    Bacman, David; Merkel, Susanne; Croner, Roland; Papadopoulos, Thomas; Brueckl, Wolfgang; Dimmler, Arno

    2007-01-01

    Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophages (TAM) on histological grade of differentiation in colon carcinoma. Disruption of transforming growth factor beta (TGF-beta) signalling in tumour cells is related to more aggressive clinical behaviour. Expression data of components of this pathway in tumour-associated stroma is limited. Tissue micro arrays of 310 colon carcinomas from curatively resected patients in UICC stage II and III were established. In a first step we quantified amount of CD68 positive TAMs and expression of components of TGF-beta signalling (TGF-beta1, TGF-beta receptors type 1 and 2, Smad 3 and 4) in tumour and associated stroma. Further we analyzed correlation to histological and clinical parameters (histological grade of differentiation (low-grade (i.e. grade 1 and 2) vs. high-grade (i.e. grade 3 and 4)), lymph node metastasis, distant metastasis, 5 year cancer related survival) using Chi-square or Fisher's exact test, when appropriate, to compare frequencies, Kaplan-Meier method to calculate 5-year rates of distant metastases and cancer-related survival and log rank test to compare the rates of distant metastases and survival. To identify independent prognostic factors Cox regression analysis including lymph node status and grading was performed. High-grade tumours and those with lymph node metastases showed higher rates of TAMs and lower expression of TGF-beta1. Loss of nuclear Smad4 expression in tumor was associated with presence of lymph node metastasis, but no influence on prognosis could be demonstrated. Decrease of both TGF-beta receptors in tumour-associated stroma was associated with increased lymph node metastasis and shorter survival. Stromal TGF-beta receptor 2

  3. TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study

    Directory of Open Access Journals (Sweden)

    Papadopoulos Thomas

    2007-08-01

    Full Text Available Abstract Background Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophages (TAM on histological grade of differentiation in colon carcinoma. Disruption of transforming growth factor beta (TGF-beta signalling in tumour cells is related to more aggressive clinical behaviour. Expression data of components of this pathway in tumour-associated stroma is limited. Methods Tissue micro arrays of 310 colon carcinomas from curatively resected patients in UICC stage II and III were established. In a first step we quantified amount of CD68 positive TAMs and expression of components of TGF-beta signalling (TGF-beta1, TGF-beta receptors type 1 and 2, Smad 3 and 4 in tumour and associated stroma. Further we analyzed correlation to histological and clinical parameters (histological grade of differentiation (low-grade (i.e. grade 1 and 2 vs. high-grade (i.e. grade 3 and 4, lymph node metastasis, distant metastasis, 5 year cancer related survival using Chi-square or Fisher's exact test, when appropriate, to compare frequencies, Kaplan-Meier method to calculate 5-year rates of distant metastases and cancer-related survival and log rank test to compare the rates of distant metastases and survival. To identify independent prognostic factors Cox regression analysis including lymph node status and grading was performed. Results High-grade tumours and those with lymph node metastases showed higher rates of TAMs and lower expression of TGF-beta1. Loss of nuclear Smad4 expression in tumor was associated with presence of lymph node metastasis, but no influence on prognosis could be demonstrated. Decrease of both TGF-beta receptors in tumour-associated stroma was associated with increased lymph node metastasis and

  4. LHC phenomenology and higher order electroweak corrections in supersymmetric models with and without R-parity

    Energy Technology Data Exchange (ETDEWEB)

    Liebler, Stefan Rainer

    2011-09-15

    leptons in case of the R-parity violating models at one-loop level. The discussion shows the similarities and differences to existing calculations in another renormalization scheme, namely the DR scheme. Moreover we consider two-body decays of the form {sub {chi}}{sup {proportional_to}}{sup 0}{sub j}{yields}{sub {chi}}{sup {proportional_to}}{sup {+-}}{sub l}W{sup -+} involving a heavy gauge boson in the final state at one-loop level. Corrections are found to be large in case of small or vanishing tree-level decay widths and also for the R-parity violating decay of the lightest neutralino {sub {chi}}{sup {proportional_to}}{sup 0}{sub 1} {yields} l{sup {+-}}W{sup -+}. An interesting feature of the models based on bilinear R-parity violation is the correlation between the branching ratios of the lightest neutralino decays and the neutrino mixing angles. We discuss these relations at tree-level and for two-body decays {sub {chi}}{sup {proportional_to}}{sup 0}{sub 1}{yields}l{sup {+-}}W{sup -+} also at one-loop level, since only the full one-loop corrections result in the tree-level expected behavior.

  5. LHC phenomenology and higher order electroweak corrections in supersymmetric models with and without R-parity

    International Nuclear Information System (INIS)

    Liebler, Stefan Rainer

    2011-09-01

    case of the R-parity violating models at one-loop level. The discussion shows the similarities and differences to existing calculations in another renormalization scheme, namely the DR scheme. Moreover we consider two-body decays of the form χ ∝0 j → χ ∝± l W -+ involving a heavy gauge boson in the final state at one-loop level. Corrections are found to be large in case of small or vanishing tree-level decay widths and also for the R-parity violating decay of the lightest neutralino χ ∝0 1 → l ± W -+ . An interesting feature of the models based on bilinear R-parity violation is the correlation between the branching ratios of the lightest neutralino decays and the neutrino mixing angles. We discuss these relations at tree-level and for two-body decays χ ∝0 1 →l ± W -+ also at one-loop level, since only the full one-loop corrections result in the tree-level expected behavior.

  6. Analysis of Static and Dynamic E-Reference Content at a Multi-Campus University Shows, that Updated Content is Associated with Greater Annual Usage

    Directory of Open Access Journals (Sweden)

    Laura Costello

    2016-03-01

    Full Text Available Objective – To discover whether there is a difference in use over time between dynamically updated and changing subscription e-reference titles and collections, and static purchased e-reference titles and collections. Design – Case study. Setting – A multi-campus Canadian university with 9,200 students enrolled in both graduate and undergraduate programs. Subjects – E-reference book packages and individual e-reference titles. Methods – The author compared data from individual e-reference books and packages. First, individual subscription e-reference books that periodically added updated content were compared to individually purchased e-reference books that remained static after purchase. The author then compared two e-reference book packages that provided new and updated content to two static e-reference book packages. The author compared data from patron usage to new content added over time using regression analysis. Main Results – As the library acquired e-reference titles, dynamic title subscriptions added to the collection were associated with 2,246 to 4,635 views per subscription while static title additions were associated with 8 to 123 views per purchase. The author also found that there was a strong linear relationship between views and dynamic titles added to the collection (R2=0.79 and a very weak linear relationship (R2=0.18 with views when static titles are added to the collection. Regression analysis of dynamic e-reference collections revealed that the number of titles added to each collection was strongly associated with views of the material (R2=0.99, while static e-reference collections were less strongly linked (R2=0.43. Conclusion – Dynamic e-reference titles and collections experienced increases in usage each year while static titles and collections experienced decreases in usage. This indicates that collections and titles that offer new content to users each year will continue to see growth in usage while static

  7. Professional Parity Between Co-Teachers in Secondary Science and Math As Influenced By Administrative Support

    Science.gov (United States)

    Nordh, Camilla S.

    2011-12-01

    School improvement plans, budget constraints, and compliance mandates targeting academic progress for all students indicate a need for maximal professional efficacy at every level in the educational system, including parity between co-teachers in the co-teaching service delivery model. However, research shows that the special education co-teacher frequently assumes an assistive role while the general education co-teacher adopts a leading role in the classroom. When the participants in a co-teaching partnership fail to equitably share the professional responsibilities for which both teachers are qualified to perform, overall efficacy is compromised in that the special education teacher is not exercising his or her qualified expertise. Administrative support can be a primary influencing factor in increasing parity between the co-teachers. A qualitative study using a phenomenological design was conducted to explore the influences of co-teacher attitudes and administrative support on professional parity in co-taught secondary science and math classrooms. Content analysis was used to interpret data from interviews with five special education and 15 general education co-teachers at eight secondary schools in a suburban school district in a mid-Atlantic state. Five themes emerged from the data: content mastery by the special education co-teacher, joint planning time for co-teachers, continuity within co-teaching dyads, compatible personalities between co-teachers, and clear administrative expectations about co-teaching. Results indicate that administrative support to consider the content mastery of the special education co-teacher is the most influential factor to parity, followed by the co-teaching partners having joint planning time and that both can be implemented through scheduling and assignment considerations rather than training initiatives. The results provide an examination of each theme as it pertains to the issue of professional efficacy in co-teaching and

  8. A naturally derived gastric cancer cell line shows latency I Epstein-Barr virus infection closely resembling EBV-associated gastric cancer

    International Nuclear Information System (INIS)

    Oh, Sang Taek; Seo, Jung Seon; Moon, Uk Yeol; Kang, Kyeong Hee; Shin, Dong-Jik; Yoon, Sungjoo Kim; Kim, Woo Ho; Park, Jae-Gahb; Lee, Suk Kyeong

    2004-01-01

    In a process seeking out a good model cell line for Epstein-Barr virus (EBV)-associated gastric cancer, we found that one previously established gastric adenocarcinoma cell line is infected with type 1 EBV. This SNU-719 cell line from a Korean patient expressed cytokeratin without CD19 or CD21 expression. In SNU-719, EBNA1 and LMP2A were expressed, while LMP1 and EBNA2 were not. None of the tested lytic EBV proteins were detected in this cell line unless stimulated with phorbol ester. EBV infection was also shown in the original carcinoma tissue of SNU-719 cell line. Our results support the possibility of a CD21-independent EBV infection of gastric epithelial cells in vivo. As the latent EBV gene expression pattern of SNU-719 closely resembles that of the EBV-associated gastric cancer, this naturally derived cell line may serve as a valuable model system to clarify the precise role of EBV in gastric carcinogenesis

  9. Flomoxef showed excellent in vitro activity against clinically important gram-positive and gram-negative pathogens causing community- and hospital-associated infections.

    Science.gov (United States)

    Yang, Qiwen; Zhang, Hui; Cheng, Jingwei; Xu, Zhipeng; Hou, Xin; Xu, Yingchun

    2015-04-01

    The objective of this study was to better understand the in vitro activity of flomoxef against clinical pathogens. A total of 545 clinical isolates, including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus, Streptococcus pneumoniae, and Streptococcus pyogenes, were isolated consecutively from clinical specimens from Peking Union Medical College Hospital in 2013. MICs were determined using broth microdilution method. esbl and ampC genes were detected by polymerase chain reaction and sequencing. Flomoxef showed excellent activity against E. coli, K. pneumoniae, and P. mirabilis isolates, with susceptibility rate of 88.8%, 88.3%, and 97.7%, separately. Moreover, flomoxef exhibited great activity against extended-spectrum beta-lactamase (ESBL) producers, with MIC50/MIC90 of 0.125/(0.5-1) μg/mL. Flomoxef showed MIC50/MIC90 of 0.5/0.5 μg/mL against MSSA, 0.125/0.25 μg/mL against S. pyogenes, and 2/16 μg/mL against S. pneumoniae. In conclusion, flomoxef is one of the cephamycins showing excellent activity against ESBL-producing or ESBL-nonproducing E. coli, K. pneumoniae, and P. mirabilis and was also potent against MSSA, S. pyogenes, and S. pneumoniae. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Towards grid parity in insular energy systems: The case of photovoltaics (PV) in Cyprus

    International Nuclear Information System (INIS)

    Fokaides, Paris A.; Kylili, Angeliki

    2014-01-01

    Grid parity is defined as the threshold at which a grid-connected renewable energy sources (RES) system supplies electricity to the end user at the same price as grid-supplied electricity. Predictions from the 2006 time-frame expected retail grid parity for solar in the 2016 to 2020 era, but due to rapid downward pricing changes, more recent calculations have forced dramatic reductions in time scale, and the suggestion that solar has already reached grid parity in a wide variety of locations. This study presents aspects of achieving grid parity in insular energy systems, based on a case study applied in Cyprus. The analysis presents the variation of the manufacturing cost, the selling price of the produced energy, and the performance of the solar panels to examine the conditions of accomplishing grid parity event. It is also concluded that grid parity may be easier achieved in insular energy systems due to the higher cost of primary energy. - Highlights: • This study presents aspects of achieving grid parity in insular energy systems, based on a case study applied in Cyprus. • The impact of the manufacturing cost and the feed in tariff on accomplishing grid parity event is analysed. • A sensitivity analysis is conducted to define the parameters that strongly affect the goal of grid parity. • It is concluded that grid parity may be easier achieved in insular energy systems due to the higher cost of primary energy

  11. Separation of the 1+/1− parity doublet in 20Ne

    Directory of Open Access Journals (Sweden)

    J. Beller

    2015-02-01

    Full Text Available The (J,T=(1,1 parity doublet in 20Ne at 11.26 MeV is a good candidate to study parity violation in nuclei. However, its energy splitting is known with insufficient accuracy for quantitative estimates of parity violating effects. To improve on this unsatisfactory situation, nuclear resonance fluorescence experiments using linearly and circularly polarized γ-ray beams were used to determine the energy difference of the parity doublet ΔE=E(1−−E(1+=−3.2(±0.7stat(−1.2+0.6sys keV and the ratio of their integrated cross sections Is,0(+/Is,0(−=29(±3stat(−7+14sys. Shell-model calculations predict a parity-violating matrix element having a value in the range 0.46–0.83 eV for the parity doublet. The small energy difference of the parity doublet makes 20Ne an excellent candidate to study parity violation in nuclear excitations. Keywords: Parity doublet, Parity violation

  12. A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease

    DEFF Research Database (Denmark)

    Holmes, Michael V; Frikke-Schmidt, Ruth; Melis, Daniela

    2014-01-01

    events in 130,004 individuals of European descent were identified. The odds ratio (OR) for CHD risk from APOE genotype (ε4 carriers versus non-carriers) was 1.06 (95% confidence interval (CI): 1.01, 1.12) and for smoking (present vs. past/never smokers) was OR 2.05 (95%CI: 1.95, 2.14). When...... the association between APOE genotype and CHD was stratified by smoking status, compared to non-ε4 carriers, ε4 carriers had an OR of 1.11 (95%CI: 1.02, 1.21) in 28,789 present smokers and an OR of 1.04 (95%CI 0.98, 1.10) in 101,215 previous/never smokers, with no evidence of effect modification (P...

  13. A Retrospective Cohort Analysis Shows that Coadministration of Minocycline with Colistin in Critically Ill Patients Is Associated with Reduced Frequency of Acute Renal Failure.

    Science.gov (United States)

    Lodise, Thomas P; Fan, Weihong; Griffith, David C; Dudley, Michael N; Sulham, Katherine A

    2018-01-01

    Nonclinical studies have suggested that oxidative damage, caspase-mediated apoptosis, and inducible nitric oxide synthase levels may be involved in the pathogenesis of colistin (CST)-associated acute renal failure. MIN inhibits caspase 1, caspase 3, and inducible nitric oxide synthase, leading to the hypothesis that coadministration of CST with MIN (CST-MIN) may reduce the incidence of acute renal failure as well as produce additive or synergistic antimicrobial effects. A multicenter retrospective cohort study was conducted using the Premier Research database to examine the impact of CST-MIN on acute renal failure. Inclusion criteria were as follows: age of ≥18 years, intensive care unit admission at CST initiation, primary International Classification of Diseases 9 (ICD-9) diagnosis of pneumonia or sepsis, nondialysis at hospital admission, and discharge between January 2010 and December 2015. ICD-9 code 584.XX or ICD-10 code N17 was used to define acute renal failure. Baseline comparisons, 1:8 propensity score matching, and confirmatory logistic regression analyses were conducted. In total, 4,817 patients received CST and met inclusion criteria; 93 received CST-MIN. Unadjusted frequency of acute renal failure was significantly lower in patients receiving CST-MIN than CST (11.8% versus 23.7%, P = 0.007). Similar results were seen in propensity score matching (12.0% versus 22.3%, P = 0.031) and logistic regression analyses (odds ratio of 0.403, P = 0.006). Mortalities and 30-day readmission rates were similar between groups. The acute renal failure rate was not impacted by prevalence of baseline renal disease. CST-MIN in critically ill patients may reduce CST-associated acute renal failure. Further evaluation of this combination in prospective clinical studies is warranted. Copyright © 2017 Lodise et al.

  14. Immune indexes of larks from desert and temperate regions show weak associations with life history but stronger links to environmental variation in microbial abundance.

    Science.gov (United States)

    Horrocks, Nicholas P C; Hegemann, Arne; Matson, Kevin D; Hine, Kathryn; Jaquier, Sophie; Shobrak, Mohammed; Williams, Joseph B; Tinbergen, Joost M; Tieleman, B Irene

    2012-01-01

    Immune defense may vary as a result of trade-offs with other life-history traits or in parallel with variation in antigen levels in the environment. We studied lark species (Alaudidae) in the Arabian Desert and temperate Netherlands to test opposing predictions from these two hypotheses. Based on their slower pace of life, the trade-off hypothesis predicts relatively stronger immune defenses in desert larks compared with temperate larks. However, as predicted by the antigen exposure hypothesis, reduced microbial abundances in deserts should result in desert-living larks having relatively weaker immune defenses. We quantified host-independent and host-dependent microbial abundances of culturable microbes in ambient air and from the surfaces of birds. We measured components of immunity by quantifying concentrations of the acute-phase protein haptoglobin, natural antibody-mediated agglutination titers, complement-mediated lysis titers, and the microbicidal ability of whole blood. Desert-living larks were exposed to significantly lower concentrations of airborne microbes than temperate larks, and densities of some bird-associated microbes were also lower in desert species. Haptoglobin concentrations and lysis titers were also significantly lower in desert-living larks, but other immune indexes did not differ. Thus, contrary to the trade-off hypothesis, we found little evidence that a slow pace of life predicted increased immunological investment. In contrast, and in support of the antigen exposure hypothesis, associations between microbial exposure and some immune indexes were apparent. Measures of antigen exposure, including assessment of host-independent and host-dependent microbial assemblages, can provide novel insights into the mechanisms underlying immunological variation.

  15. Fungi on white-nose infected bats (Myotis spp. in Eastern Canada show no decline in diversity associated with Pseudogymnoascus destructans (Ascomycota: Pseudeurotiaceae

    Directory of Open Access Journals (Sweden)

    Karen J. Vanderwolf

    2016-01-01

    Full Text Available The introduction of the fungal pathogen Pseudogymnoascus destructans (Pd to North America has stimulated research on the poorly known mycology of caves. It is possible that the introduction of Pd reduces the diversity of fungi associated with bats hibernating in caves. To test this hypothesis we examined the fungal assemblages associated with hibernating bats (Myotis spp. pre- and post- white-nose syndrome (WNS infection in eastern Canada using culture-dependent methods. We found the mean number of fungal taxa isolated from bats/hibernaculum was not significantly different between pre-infection (29.6 ± 6.1SD and post-infection with WNS (32.4 ± 4.3. Although the number of fungal taxa per bat was significantly higher on Myotis lucifugus vs. M. septentrionalis, evidence suggests that this is a reflection of environmental features of individual hibernacula, rather than any biological difference between bat species. The composition and number of the most common and widespread fungal taxa on hibernating Myotis spp. did not change with the introduction of Pd to hibernacula. We found no evidence to suggest that Pd interacts with other fungi on the external surface of bats in hibernacula, even among fungal species of the same genus. However, our data do suggest that environmental characteristics of individual caves can have a significant influence on the fungal assemblages cultured from hibernating bats at specific hibernacula. Following the mortality of thousands of WNS-infected Myotis spp. in one hibernacula, we found that those fungal taxa growing on dead bats were cultured with increased frequency from live bats. This suggests that fungal assemblages on live bats may be sensitive to sporadic introductions of new fungal substrates to hibernacula.

  16. Spatially coupled low-density parity-check error correction for holographic data storage

    Science.gov (United States)

    Ishii, Norihiko; Katano, Yutaro; Muroi, Tetsuhiko; Kinoshita, Nobuhiro

    2017-09-01

    The spatially coupled low-density parity-check (SC-LDPC) was considered for holographic data storage. The superiority of SC-LDPC was studied by simulation. The simulations show that the performance of SC-LDPC depends on the lifting number, and when the lifting number is over 100, SC-LDPC shows better error correctability compared with irregular LDPC. SC-LDPC is applied to the 5:9 modulation code, which is one of the differential codes. The error-free point is near 2.8 dB and over 10-1 can be corrected in simulation. From these simulation results, this error correction code can be applied to actual holographic data storage test equipment. Results showed that 8 × 10-2 can be corrected, furthermore it works effectively and shows good error correctability.

  17. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    Science.gov (United States)

    Jackson, Anne U.; Monda, Keri L.; Kilpeläinen, Tuomas O.; Esko, Tõnu; Mägi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; Feitosa, Mary F.; Croteau-Chonka, Damien C.; Day, Felix R.; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; Locke, Adam E.; Mathieson, Iain; Scherag, Andre; Vedantam, Sailaja; Wood, Andrew R.; Liang, Liming; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Dermitzakis, Emmanouil T.; Dimas, Antigone S.; Karpe, Fredrik; Min, Josine L.; Nicholson, George; Clegg, Deborah J.; Person, Thomas; Krohn, Jon P.; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amélie; Froguel, Philippe; Hottenga, Jouke-Jan; Prokopenko, Inga; Waite, Lindsay L.; Harris, Tamara B.; Smith, Albert Vernon; Shuldiner, Alan R.; McArdle, Wendy L.; Caulfield, Mark J.; Munroe, Patricia B.; Grönberg, Henrik; Chen, Yii-Der Ida; Li, Guo; Beckmann, Jacques S.; Johnson, Toby; Thorsteinsdottir, Unnur; Teder-Laving, Maris; Khaw, Kay-Tee; Wareham, Nicholas J.; Zhao, Jing Hua; Amin, Najaf; Oostra, Ben A.; Kraja, Aldi T.; Province, Michael A.; Cupples, L. Adrienne; Heard-Costa, Nancy L.; Kaprio, Jaakko; Ripatti, Samuli; Surakka, Ida; Collins, Francis S.; Saramies, Jouko; Tuomilehto, Jaakko; Jula, Antti; Salomaa, Veikko; Erdmann, Jeanette; Hengstenberg, Christian; Loley, Christina; Schunkert, Heribert; Lamina, Claudia; Wichmann, H. Erich; Albrecht, Eva; Gieger, Christian; Hicks, Andrew A.; Johansson, Åsa; Pramstaller, Peter P.; Kathiresan, Sekar; Speliotes, Elizabeth K.; Penninx, Brenda; Hartikainen, Anna-Liisa; Jarvelin, Marjo-Riitta; Gyllensten, Ulf; Boomsma, Dorret I.; Campbell, Harry; Wilson, James F.; Chanock, Stephen J.; Farrall, Martin; Goel, Anuj; Medina-Gomez, Carolina; Rivadeneira, Fernando; Estrada, Karol; Uitterlinden, André G.; Hofman, Albert; Zillikens, M. Carola; den Heijer, Martin; Kiemeney, Lambertus A.; Maschio, Andrea; Hall, Per; Tyrer, Jonathan; Teumer, Alexander; Völzke, Henry; Kovacs, Peter; Tönjes, Anke; Mangino, Massimo; Spector, Tim D.; Hayward, Caroline; Rudan, Igor; Hall, Alistair S.; Samani, Nilesh J.; Attwood, Antony Paul; Sambrook, Jennifer G.; Hung, Joseph; Palmer, Lyle J.; Lokki, Marja-Liisa; Sinisalo, Juha; Boucher, Gabrielle; Huikuri, Heikki; Lorentzon, Mattias; Ohlsson, Claes; Eklund, Niina; Eriksson, Johan G.; Barlassina, Cristina; Rivolta, Carlo; Nolte, Ilja M.; Snieder, Harold; Van der Klauw, Melanie M.; Van Vliet-Ostaptchouk, Jana V.; Gejman, Pablo V.; Shi, Jianxin; Jacobs, Kevin B.; Wang, Zhaoming; Bakker, Stephan J. L.; Mateo Leach, Irene; Navis, Gerjan; van der Harst, Pim; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Yang, Jian; Chasman, Daniel I.; Ridker, Paul M.; Rose, Lynda M.; Lehtimäki, Terho; Raitakari, Olli; Absher, Devin; Iribarren, Carlos; Basart, Hanneke; Hovingh, Kees G.; Hyppönen, Elina; Power, Chris; Anderson, Denise; Beilby, John P.; Hui, Jennie; Jolley, Jennifer; Sager, Hendrik; Bornstein, Stefan R.; Schwarz, Peter E. H.; Kristiansson, Kati; Perola, Markus; Lindström, Jaana; Swift, Amy J.; Uusitupa, Matti; Atalay, Mustafa; Lakka, Timo A.; Rauramaa, Rainer; Bolton, Jennifer L.; Fowkes, Gerry; Fraser, Ross M.; Price, Jackie F.; Fischer, Krista; KrjutÅ¡kov, Kaarel; Metspalu, Andres; Mihailov, Evelin; Langenberg, Claudia; Luan, Jian'an; Ong, Ken K.; Chines, Peter S.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Edkins, Sarah; Franks, Paul W.; Hallmans, Göran; Shungin, Dmitry; Morris, Andrew David; Palmer, Colin N. A.; Erbel, Raimund; Moebus, Susanne; Nöthen, Markus M.; Pechlivanis, Sonali; Hveem, Kristian; Narisu, Narisu; Hamsten, Anders; Humphries, Steve E.; Strawbridge, Rona J.; Tremoli, Elena; Grallert, Harald; Thorand, Barbara; Illig, Thomas; Koenig, Wolfgang; Müller-Nurasyid, Martina; Peters, Annette; Boehm, Bernhard O.; Kleber, Marcus E.; März, Winfried; Winkelmann, Bernhard R.; Kuusisto, Johanna; Laakso, Markku; Arveiler, Dominique; Cesana, Giancarlo; Kuulasmaa, Kari; Virtamo, Jarmo; Yarnell, John W. G.; Kuh, Diana; Wong, Andrew; Lind, Lars; de Faire, Ulf; Gigante, Bruna; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Dedoussis, George; Dimitriou, Maria; Kolovou, Genovefa; Kanoni, Stavroula; Stirrups, Kathleen; Bonnycastle, Lori L.; Njølstad, Inger; Wilsgaard, Tom; Ganna, Andrea; Rehnberg, Emil; Hingorani, Aroon; Kivimaki, Mika; Kumari, Meena; Assimes, Themistocles L.; Barroso, Inês; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Frayling, Timothy; Groop, Leif C.; Haritunians, Talin; Hunter, David; Ingelsson, Erik; Kaplan, Robert; Mohlke, Karen L.; O'Connell, Jeffrey R.; Schlessinger, David; Strachan, David P.; Stefansson, Kari; van Duijn, Cornelia M.; Abecasis, Gonçalo R.; McCarthy, Mark I.; Hirschhorn, Joel N.; Qi, Lu; Loos, Ruth J. F.; Lindgren, Cecilia M.; North, Kari E.; Heid, Iris M.

    2013-01-01

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10−8), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits. PMID:23754948

  18. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.

    Directory of Open Access Journals (Sweden)

    Joshua C Randall

    2013-06-01

    Full Text Available Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals and took forward 348 SNPs into follow-up (additional 137,052 individuals in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%, including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9 and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG, all of which were genome-wide significant in women (P<5×10(-8, but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits.

  19. Gene Expressing and sRNA Sequencing Show That Gene Differentiation Associates with a Yellow Acer palmatum Mutant Leaf in Different Light Conditions.

    Science.gov (United States)

    Li, Shu-Shun; Li, Qian-Zhong; Rong, Li-Ping; Tang, Ling; Zhang, Bo

    2015-01-01

    Acer palmatum Thunb., like other maples, is a widely ornamental-use small woody tree for leaf shapes and colors. Interestingly, we found a yellow-leaves mutant "Jingling Huangfeng" turned to green when grown in shade or low-density light condition. In order to study the potential mechanism, we performed high-throughput sequencing and obtained 1,082 DEGs in leaves grown in different light conditions that result in A. palmatum significant morphological and physiological changes. A total of 989 DEGs were annotated and clustered, of which many DEGs were found associating with the photosynthesis activity and pigment synthesis. The expression of CHS and FDR gene was higher while the expression of FLS gene was lower in full-sunlight condition; this may cause more colorful substance like chalcone and anthocyanin that were produced in full-light condition, thus turning the foliage to yellow. Moreover, this is the first available miRNA collection which contains 67 miRNAs of A. palmatum, including 46 conserved miRNAs and 21 novel miRNAs. To get better understanding of which pathways these miRNAs involved, 102 Unigenes were found to be potential targets of them. These results will provide valuable genetic resources for further study on the molecular mechanisms of Acer palmatum leaf coloration.

  20. Coupled Imaging with [18F]FBB and [18F]FDG in AD Subjects Show a Selective Association Between Amyloid Burden and Cortical Dysfunction in the Brain.

    Science.gov (United States)

    Chiaravalloti, Agostino; Castellano, Anna Elisa; Ricci, Maria; Barbagallo, Gaetano; Sannino, Pasqualina; Ursini, Francesco; Karalis, Georgios; Schillaci, Orazio

    2018-02-05

    The present study was aimed to investigate the relationships between dysfunction of cortical glucose metabolism as detectable by means of 2-deoxy-2-[ 18 F]fluoro -D-glucose ([ 18 F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) and amyloid burden as detectable by means of 4-{(E)-2-[4-(2-{2-[2-[ 18 F]fluoroethoxy]ethoxy}ethoxy)phenyl]vinyl}-N-methylaniline (florbetaben; [ 18 F]FBB) in a group of patients affected by Alzheimer's disease (AD). We examined 38 patients newly diagnosed with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a PET/CT scan using both [ 18 F]FDG and [ 18 F]FBB with an average interval of 1 month. We used statistical parametric mapping (SPM8) implemented in Matlab R2012b and WFU pickatlas for the definition of a region of interest (ROI) mask including the whole cortex. These data were then normalized on the counts of the cerebellum and then used for a regression analysis on [ 18 F]FDG scans in SPM. Furthermore, 58 control subjects were used as control group for [ 18 F]FDG PET/CT scans. SPM analysis in AD patients showed a significant negative correlation between [ 18 F] FBB and [ 18 F] FDG uptake in temporal and parietal lobes bilaterally. Of note, these areas in AD patients displayed a marked glucose hypometabolism compared to control group. Combined imaging with [ 18 F]FBB and [ 18 FFDG shows that amyloid burden in the brain is related to cortical dysfunction of temporal and parietal lobes in AD.

  1. Domestic sheep show average Coxiella burnetii seropositivity generations after a sheep-associated human Q fever outbreak and lack detectable shedding by placental, vaginal, and fecal routes

    Science.gov (United States)

    Oliveira, Ryan D.; Mousel, Michelle R.; Pabilonia, Kristy L.; Highland, Margaret A.; Taylor, J. Bret; Knowles, Donald P.

    2017-01-01

    Coxiella burnetii is a globally distributed zoonotic bacterial pathogen that causes abortions in ruminant livestock. In humans, an influenza-like illness results with the potential for hospitalization, chronic infection, abortion, and fatal endocarditis. Ruminant livestock, particularly small ruminants, are hypothesized to be the primary transmission source to humans. A recent Netherlands outbreak from 2007–2010 traced to dairy goats resulted in over 4,100 human cases with estimated costs of more than 300 million euros. Smaller human Q fever outbreaks of small ruminant origin have occurred in the United States, and characterizing shedding is important to understand the risk of future outbreaks. In this study, we assessed bacterial shedding and seroprevalence in 100 sheep from an Idaho location associated with a 1984 human Q fever outbreak. We observed 5% seropositivity, which was not significantly different from the national average of 2.7% for the U.S. (P>0.05). Furthermore, C. burnetii was not detected by quantitative PCR from placentas, vaginal swabs, or fecal samples. Specifically, a three-target quantitative PCR of placenta identified 0.0% shedding (exact 95% confidence interval: 0.0%-2.9%). While presence of seropositive individuals demonstrates some historical C. burnetii exposure, the placental sample confidence interval suggests 2016 shedding events were rare or absent. The location maintained the flock with little or no depopulation in 1984 and without C. burnetii vaccination during or since 1984. It is not clear how a zero-shedding rate was achieved in these sheep beyond natural immunity, and more work is required to discover and assess possible factors that may contribute towards achieving zero-shedding status. We provide the first U.S. sheep placental C. burnetii shedding update in over 60 years and demonstrate potential for C. burnetii shedding to reach undetectable levels after an outbreak event even in the absence of targeted interventions, such

  2. Domestic sheep show average Coxiella burnetii seropositivity generations after a sheep-associated human Q fever outbreak and lack detectable shedding by placental, vaginal, and fecal routes.

    Directory of Open Access Journals (Sweden)

    Ryan D Oliveira

    Full Text Available Coxiella burnetii is a globally distributed zoonotic bacterial pathogen that causes abortions in ruminant livestock. In humans, an influenza-like illness results with the potential for hospitalization, chronic infection, abortion, and fatal endocarditis. Ruminant livestock, particularly small ruminants, are hypothesized to be the primary transmission source to humans. A recent Netherlands outbreak from 2007-2010 traced to dairy goats resulted in over 4,100 human cases with estimated costs of more than 300 million euros. Smaller human Q fever outbreaks of small ruminant origin have occurred in the United States, and characterizing shedding is important to understand the risk of future outbreaks. In this study, we assessed bacterial shedding and seroprevalence in 100 sheep from an Idaho location associated with a 1984 human Q fever outbreak. We observed 5% seropositivity, which was not significantly different from the national average of 2.7% for the U.S. (P>0.05. Furthermore, C. burnetii was not detected by quantitative PCR from placentas, vaginal swabs, or fecal samples. Specifically, a three-target quantitative PCR of placenta identified 0.0% shedding (exact 95% confidence interval: 0.0%-2.9%. While presence of seropositive individuals demonstrates some historical C. burnetii exposure, the placental sample confidence interval suggests 2016 shedding events were rare or absent. The location maintained the flock with little or no depopulation in 1984 and without C. burnetii vaccination during or since 1984. It is not clear how a zero-shedding rate was achieved in these sheep beyond natural immunity, and more work is required to discover and assess possible factors that may contribute towards achieving zero-shedding status. We provide the first U.S. sheep placental C. burnetii shedding update in over 60 years and demonstrate potential for C. burnetii shedding to reach undetectable levels after an outbreak event even in the absence of targeted

  3. Characteristics of unnatural parity meson exchange term, and nonevasive component

    International Nuclear Information System (INIS)

    Bando, Masako

    1974-01-01

    The characteristics of scattering amplitude, which were found from the amplitude analysis of π (K)N scattering, are as follows. The Regge pole model of natural parity mesons is good for s dependence. The behavior of the imaginary part of the amplitude is stipulated by Δn(s channel net helicity flip). The phase is in agreement with Regge phase for Δn=1, but deviates for Δn=0. EXD is almost good except tensor meson exchange part. Relations such as Isub(t)=1 in case of /f sub(Δn=1)/>>/f sub(Δn=0)/, and Isub(t)=0 in case of /f sub(Δn=0)/>>/f sub(Δn=1)/ exist between the magnitudes of t channel exchanged quantum number and residue. The consistent theory for two body scattering amplitude has not yet been obtained. As examples, the processes Psub(s)B → VB (or Δ) and γN → Psub(s)B (or Δ) were analyzed, The s dependence and the t dependence of the cross section were investigated. The resonance amplitude for γN → Psub(s)B (or Δ) has been studied with resonance parameters. The position of dip and the coupling strength were found. These data resulted from the separation of natural parity meson exchange and unnatural parity meson exchange. The matching with the model amplitude in photo - π production process was examined. Construction of the model amplitude and the remaining problems are introduced and discussed. (Kato, T.)

  4. Robust wireless power transfer using a nonlinear parity-time-symmetric circuit.

    Science.gov (United States)

    Assawaworrarit, Sid; Yu, Xiaofang; Fan, Shanhui

    2017-06-14

    Considerable progress in wireless power transfer has been made in the realm of non-radiative transfer, which employs magnetic-field coupling in the near field. A combination of circuit resonance and impedance transformation is often used to help to achieve efficient transfer of power over a predetermined distance of about the size of the resonators. The development of non-radiative wireless power transfer has paved the way towards real-world applications such as wireless powering of implantable medical devices and wireless charging of stationary electric vehicles. However, it remains a fundamental challenge to create a wireless power transfer system in which the transfer efficiency is robust against the variation of operating conditions. Here we propose theoretically and demonstrate experimentally that a parity-time-symmetric circuit incorporating a nonlinear gain saturation element provides robust wireless power transfer. Our results show that the transfer efficiency remains near unity over a distance variation of approximately one metre, without the need for any tuning. This is in contrast with conventional methods where high transfer efficiency can only be maintained by constantly tuning the frequency or the internal coupling parameters as the transfer distance or the relative orientation of the source and receiver units is varied. The use of a nonlinear parity-time-symmetric circuit should enable robust wireless power transfer to moving devices or vehicles.

  5. New birthweight charts according to parity and type of delivery for the Spanish population.

    Science.gov (United States)

    Terán, José Manuel; Varea, Carlos; Bernis, Cristina; Bogin, Barry; González-González, Antonio

    Birthweight by gestational age charts enable fetal growth to be evaluated in a specific population. Given that maternal profile and obstetric practice have undergone a remarkable change over the past few decades in Spain, this paper presents new Spanish reference percentile charts stratified by gender, parity and type of delivery. They have been prepared with data from the 2010-2014 period of the Spanish Birth Statistics Bulletin. Reference charts have been prepared using the LMS method, corresponding to 1,428,769 single, live births born to Spanish mothers. Percentile values and mean birth weight are compared among newborns according to gender, parity and type of delivery. Newborns to primiparous mothers show significantly lower birthweight than those born to multiparous mothers (pparity and type of delivery-specific birthweight references. These new charts enable a better evaluation of the impact of the demographic, reproductive and obstetric trends currently in Spain on fetal growth. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. Poincare gauge theory of gravity: Friedman cosmology with even and odd parity modes: Analytic part

    International Nuclear Information System (INIS)

    Baekler, Peter; Hehl, Friedrich W.; Nester, James M.

    2011-01-01

    We propose a cosmological model in the framework of the Poincare gauge theory of gravity (PG). The gravitational Lagrangian is quadratic in both curvature and torsion. In our specific model, the Lagrangian contains (i) the curvature scalar R and the curvature pseudoscalar X linearly and quadratically (including an RX term) and (ii) pieces quadratic in the torsion vector V and the torsion axial vector A (including a VA term). We show generally that in quadratic PG models we have nearly the same number of parity conserving terms ('world') and of parity violating terms ('shadow world'). This offers new perspectives in cosmology for the coupling of gravity to matter and antimatter. Our specific model generalizes the fairly realistic ''torsion cosmologies'' of Shie-Nester-Yo (2008) and Chen et al. (2009). With a Friedman type ansatz for an orthonormal coframe and a Lorentz connection, we derive the two field equations of PG in an explicit form and discuss their general structure in detail. In particular, the second field equation can be reduced to first order ordinary differential equations for the curvature pieces R(t) and X(t). Including these along with certain relations obtained from the first field equation and curvature definitions, we present a first order system of equations suitable for numerical evaluation. This is deferred to the second, numerical part of this paper.

  7. Error Correction using Quantum Quasi-Cyclic Low-Density Parity-Check(LDPC) Codes

    Science.gov (United States)

    Jing, Lin; Brun, Todd; Quantum Research Team

    Quasi-cyclic LDPC codes can approach the Shannon capacity and have efficient decoders. Manabu Hagiwara et al., 2007 presented a method to calculate parity check matrices with high girth. Two distinct, orthogonal matrices Hc and Hd are used. Using submatrices obtained from Hc and Hd by deleting rows, we can alter the code rate. The submatrix of Hc is used to correct Pauli X errors, and the submatrix of Hd to correct Pauli Z errors. We simulated this system for depolarizing noise on USC's High Performance Computing Cluster, and obtained the block error rate (BER) as a function of the error weight and code rate. From the rates of uncorrectable errors under different error weights we can extrapolate the BER to any small error probability. Our results show that this code family can perform reasonably well even at high code rates, thus considerably reducing the overhead compared to concatenated and surface codes. This makes these codes promising as storage blocks in fault-tolerant quantum computation. Error Correction using Quantum Quasi-Cyclic Low-Density Parity-Check(LDPC) Codes.

  8. Robust wireless power transfer using a nonlinear parity-time-symmetric circuit

    Science.gov (United States)

    Assawaworrarit, Sid; Yu, Xiaofang; Fan, Shanhui

    2017-06-01

    Considerable progress in wireless power transfer has been made in the realm of non-radiative transfer, which employs magnetic-field coupling in the near field. A combination of circuit resonance and impedance transformation is often used to help to achieve efficient transfer of power over a predetermined distance of about the size of the resonators. The development of non-radiative wireless power transfer has paved the way towards real-world applications such as wireless powering of implantable medical devices and wireless charging of stationary electric vehicles. However, it remains a fundamental challenge to create a wireless power transfer system in which the transfer efficiency is robust against the variation of operating conditions. Here we propose theoretically and demonstrate experimentally that a parity-time-symmetric circuit incorporating a nonlinear gain saturation element provides robust wireless power transfer. Our results show that the transfer efficiency remains near unity over a distance variation of approximately one metre, without the need for any tuning. This is in contrast with conventional methods where high transfer efficiency can only be maintained by constantly tuning the frequency or the internal coupling parameters as the transfer distance or the relative orientation of the source and receiver units is varied. The use of a nonlinear parity-time-symmetric circuit should enable robust wireless power transfer to moving devices or vehicles.

  9. Correlation between parity and concentration of immunoglobulins A, G and M in human colostrum

    Directory of Open Access Journals (Sweden)

    Gabriel André João Striker

    2003-06-01

    Full Text Available Objective: To study the relationship between parity andimmunoglobulin concentrations in human colostrum. Methods:82 puerperas aged 21-41 years were selected, with gestationalage ≥ 37 weeks, up to the fourth parity, good nutritional status andno gestational or puerperal diseases. The inclusion criteria for thenewborn were: weight > 2,500 g, Apgar score > 7 in the firstminute and exclusive maternal breastfeeding until discharge fromthe nursery. The mothers were divided into 2 groups: A -primiparous, B - multiparous. Colostrum was collected manuallyfrom 48 to 72 hours after delivery and the immunoglobulins weremeasured by ELISA technique. Results: No differences wereobserved regarding timing to collect colostrum; the earliercolostrum was collected, the higher the concentration of immunoglobulinA; primiparous women showed higher concentrations of IgA andIgM in their colostrum than multiparous women; there were nodifferences regarding IgG concentrations in the two groups.Conclusion: Primiparous women presented higher concentrationsof IgA and IgM in their colostrum than multiparous women.

  10. Male chimpanzees' grooming rates vary by female age, parity, and fertility status.

    Science.gov (United States)

    Proctor, Darby P; Lambeth, Susan P; Schapiro, Steven J; Brosnan, Sarah F

    2011-10-01

    Copulation preferences in our closest living relative, the chimpanzee, suggest that males prefer older females who have had previous offspring. However, this finding is counter to some behavioral models, which predict that chimpanzee males, as promiscuous breeders with minimal costs to mating, should show little or no preference when choosing mating partners (e.g. should mate indiscriminately). To determine if the preferences indicated by copulations appear in other contexts as well as how they interact, we examined how male chimpanzees' grooming patterns varied amongst females. We found that males' preferences were based on interactions among females' fertility status, age, and parity. First, grooming increased with increasing female parity. We further found an effect of the estrous cycle on grooming; when females were at the lowest point of their cycle, males preferentially groomed parous females at peak reproductive age, but during maximal tumescence, males preferred the oldest multiparous females. Nulliparous females received relatively little grooming regardless of age or fertility. Thus, male chimpanzees apparently chose grooming partners based on both female's experience and fertility, possibly indicating a two-pronged social investment strategy. Male selectivity seems to have evolved to effectively distribute costly social resources in a pattern which may increase their overall reproductive success. © 2011 Wiley-Liss, Inc.

  11. Genotypic and phenotypic analysis of familial male breast cancer shows under representation of the HER2 and basal subtypes in BRCA-associated carcinomas

    International Nuclear Information System (INIS)

    Deb, Siddhartha; Jene, Nicholas; Fox, Stephen B

    2012-01-01

    Male breast cancer (MBC) is an uncommon and relatively uncharacterised disease accounting for <1% of all breast cancers. A significant proportion occurs in families with a history of breast cancer and in particular those carrying BRCA2 mutations. Here we describe clinicopathological features and genomic BRCA1 and BRCA2 mutation status in a large cohort of familial MBCs. Cases (n=60) included 3 BRCA1 and 25 BRCA2 mutation carries, and 32 non-BRCA1/2 (BRCAX) carriers with strong family histories of breast cancer. The cohort was examined with respect to mutation status, clinicopathological parameters including TNM staging, grade, histological subtype and intrinsic phenotype. Compared to the general population, MBC incidence was higher in all subgroups. In contrast to female breast cancer (FBC) there was greater representation of BRCA2 tumours (41.7% vs 8.3%, p=0.0008) and underrepresentation of BRCA1 tumours (5.0% vs 14.4%, p=0.0001). There was no correlation between mutation status and age of onset, disease specific survival (DSS) or other clincopathological factors. Comparison with sporadic MBC studies showed similar clinicopathological features. Prognostic variables affecting DSS included primary tumour size (p=0.003, HR:4.26 95%CI 1.63-11.11), age (p=0.002, HR:4.09 95%CI 1.65-10.12), lymphovascular (p=0.019, HR:3.25 95%CI 1.21-8.74) and perineural invasion (p=0.027, HR:2.82 95%CI 1.13-7.06). Unlike familial FBC, the histological subtypes seen in familial MBC were more similar to those seen in sporadic MBC with 46 (76.7%) pure invasive ductal carcinoma of no special type (IDC-NST), 2 (3.3%) invasive lobular carcinomas and 4 (6.7%) invasive papillary carcinoma. A further 8 (13.3%) IDC-NST had foci of micropapillary differentiation, with a strong trend for co-occurrence in BRCA2 carriers (p=0.058). Most tumours were of the luminal phenotype (89.7%), with infrequent HER2 (8.6%) and basal (1.7%) phenotype tumours seen. MBC in BRCA1/2 carriers and BRCAX families is

  12. Di-(2-ethylhexyl phthalate metabolites in urine show age-related changes and associations with adiposity and parameters of insulin sensitivity in childhood.

    Directory of Open Access Journals (Sweden)

    Arianna Smerieri

    Full Text Available Phthalates might be implicated with obesity and insulin sensitivity. We evaluated the levels of primary and secondary metabolites of Di-(2-ethylhexyl phthalate (DEHP in urine in obese and normal-weight subjects both before and during puberty, and investigated their relationships with auxological parameters and indexes of insulin sensitivity.DEHP metabolites (MEHP, 6-OH-MEHP, 5-oxo-MEHP, 5-OH-MEHP, and 5-CX-MEHP, were measured in urine by RP-HPLC-ESI-MS. Traditional statistical analysis and a data mining analysis using the Auto-CM analysis were able to offer an insight into the complex biological connections between the studied variables.The data showed changes in DEHP metabolites in urine related with obesity, puberty, and presence of insulin resistance. Changes in urine metabolites were related with age, height and weight, waist circumference and waist to height ratio, thus to fat distribution. In addition, clear relationships in both obese and normal-weight subjects were detected among MEHP, its products of oxidation and measurements of insulin sensitivity.It remains to be elucidated whether exposure to phthalates per se is actually the risk factor or if the ability of the body to metabolize phthalates is actually the key point. Further studies that span from conception to elderly subjects besides further understanding of DEHP metabolism are warranted to clarify these aspects.

  13. Meta-analysis of diffusion tensor imaging (DTI) studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression

    LENUS (Irish Health Repository)

    Murphy, Melissa L

    2011-09-27

    Abstract Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

  14. Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression.

    LENUS (Irish Health Repository)

    Murphy, Melissa L

    2011-09-01

    Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

  15. Effects of the R-parity violation in the minimal supersymmetric standard model on dilepton pair production at the CERN LHC

    CERN Document Server

    Jun, Y; Lang-Hui, W; Ren Zhao You; Jun, Yin; Wen-Gan, Ma; Lang-Hui, Wan; Ren-You, Zhang

    2002-01-01

    We investigate in detail the effects of the R-parity lepton number violation in the minimal supersymmetric standard model (MSSM) on the parent process $pp \\to e^+ e^- + X$ at the CERN Large Hadron Collider (LHC). The numerical comparisons between the contributions of the R-parity violating effects to the parent process via the Drell-Yan subprocess and the gluon-gluon fusion are made. We find that the R-violating effects on $e^+ e^-$ pair production at the LHC could be significant. The results show that the cross section of the $ e^+ e^-$ pair productions via gluon-gluon collision at the LHC can be of the order of $10^2$ fb, and this subprocess maybe competitive with the production mechanism via the Drell-Yan subprocess. We give also quantitatively the analysis of the effects from both the mass of sneutrino and coupling strength of the R-parity violating interactions.

  16. Parity Differences in Heat Expression of Dairy Cows Synchronized with GnRH, CIDR and PGF2α during Dry Season in Zambia

    Directory of Open Access Journals (Sweden)

    E. S. Mwaanga*, K. Choongo, H. Simukoko and C. Chama1

    2012-01-01

    Full Text Available A study was conducted to investigate parity differences in heat expression of dairy cows heat-synchronized during the dry season when feed scarcity is common. Cyclic cows (n=65 aged 2 to 10 years with parity range of 0 to 7 were selected from small-holder dairy farms around Lusaka. Cows were divided into 3 groups of nulliparous, primiparous and pluriparous. Heat-was synchronized using gonadotrophin releasing hormone (GnRH and controlled intra-vaginal drug releasing device (CIDR. Heat detection was observed after CIDR withdraw. The study showed a significantly (P<0.05 lower number of primiparous cows (68% coming into heat compared to nulliparous (81.8% and pluriparous cows (83.3%. It was concluded that parity influences estrus expression rate in dairy cows following synchronization with GnRH, CIDR and PGF2α during the dry season in the sub-tropics.

  17. Parity of Θ+(1540) from QCD sum rules

    International Nuclear Information System (INIS)

    Lee, Su Houng; Kim, Hungchong; Kwon, Youngshin

    2005-01-01

    The QCD sum rule for the pentaquark Θ + , first analyzed by Sugiyama, Doi and Oka, is reanalyzed with a phenomenological side that explicitly includes the contribution from the two-particle reducible kaon-nucleon intermediate state. The magnitude for the overlap of the Θ + interpolating current with the kaon-nucleon state is obtained by using soft-kaon theorem and a separate sum rule for the ground state nucleon with the pentaquark nucleon interpolating current. It is found that the K-N intermediate state constitutes only 10% of the sum rule so that the original claim that the parity of Θ + is negative remains valid

  18. Parity Doubling and the S Parameter below the Conformal Window

    International Nuclear Information System (INIS)

    Appelquist, T.; Fleming, G. T.; Lin, M. F.; Neil, E. T.; Babich, R.; Brower, R. C.; Cohen, S. D.; Rebbi, C.; Schaich, D.; Cheng, M.; Vranas, P. M.; Clark, M. A.; Kiskis, J.; Osborn, J. C.

    2011-01-01

    We describe a lattice simulation of the masses and decay constants of the lowest-lying vector and axial resonances, and the electroweak S parameter, in an SU(3) gauge theory with N f =2 and 6 fermions in the fundamental representation. The spectrum becomes more parity doubled and the S parameter per electroweak doublet decreases when N f is increased from 2 to 6, motivating study of these trends as N f is increased further, toward the critical value for transition from confinement to infrared conformality.

  19. PENENTUAN NILAI TUKAR: PENGUJIAN PURCHASING POWER PARITY DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Yani Kusumastuti

    2016-11-01

    PPP to data drawn from the period 1969.1 through 2001.4. The tests are also run for sub-periods. Symmetry and proportionality restrictions find little support for the unit root tests though the Johansen test suggests that foreign exchange rate and inflation rate are linked in a long run sense. Error correction models are then estimated on the basis of the assumption that the United States inflation rate is exogenous. The error correction models result also rejects the PPP. Keywords: purchasing power parity, exchage rate

  20. Determining the Exchange Rate: Purchasing Power Parity – PPP

    Directory of Open Access Journals (Sweden)

    Bangun WIDOYOKO

    2018-05-01

    Full Text Available This study aimed to examine the effect of inflation on the issue of exchange rate determination of the forward exchange rate on the exchange rate of RMB (Renminbi to Rupiah. Inflation has been chosen as an independent variable because of its close relation to PPP (purchasing power parity theory. Analyses in this research have used logistic analysis with time series data. The data that has been used include exchange rate data with the period 2007-2017 with a sample size of 132 data. The results of this study have shown that inflation is effective in determining the exchange rate.