Full Text Available Parapsoriasis is a dermatological term for a group of chronic erythematosquamous skin disorders, which share their clinical features and possibility of progression to cutaneous T-cell lymphoma. Classification and terminology of parapasoriasis in the literature is not uniform. The term parapsoriasis in its narrower sense includes two conditions, small plaque parapsoriasis and large plaque parapsoriasis. The etiopathogenesis of this disease is not explained sufficiently. Recently, the concept of clonal dermatitis has been proposed, which defines parapsoriasis as a benign lymphoproliferative disorder with proliferation of CD4+ T-cells. Parapsoriasis is considered as a transitional step between chronic dermatitis with polyclonal lymphocyte infiltrate and cutaneous T-cell lymphoma. In small patch parapsoriasis, tendency of progression to cutaneous T-cell lymphoma is low but can occur in at least 10% of patients with large patch parapsoriasis within a decade.Establishing the correct diagnosis requires thorough correlation of clinical features and histopathological skin examination. Immunophenotype of lymphocytes and determination of their clonality with molecular biological methods can help in distinguishing parapsoriasis from cutaneous T-cell lymphoma. For therapy of parapsoriasis, topical corticosteroids and phototherapy are usually sufficient. The key factor in an approach to parapsoriasis is regular follow-up of patients to assess the risk of progression to cutaneous T-cell lymphoma. In the article, current aspects on parapsoriasis and recommendations for management of patients are presented.
Nag, Falguni; Ghosh, Arghyaprasun; Biswas, Projna; Chatterjee, Gobinda; Biswas, Saugato
Large plaque parapsoriasis (LPP) is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity.
Full Text Available Large plaque parapsoriasis (LPP is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity.
Selective UV-Phototherapy with lambda 300-320 nm (SUP) as well as oral photochemotherapy with 8-methoxy-psoralen plus UVA-radiation (PUVA intern) are very effective in clearing the lesions of the generalized psoriasis and those of the chronic forms of parapsoriasis. Being treated with 4 suberythemal doses per week psoriasis patients are free or nearly free of symptoms after averagely 6.3 weeks of SUP-therapy or after 5.3 weeks of PUVA orally. The PUVA-therapy is mainly indicated in pustular, inverse and erythrodermic psoriasis as well as in parapsoriasis en plaques and variegata. In all other forms of psoriasis and in pityriasis lichenoides-chronica, we prefer the SUP-therapy because of less acute or chronic side effects, and because of its better practicability. X-rays are indicated in psoriais of nails, grenz-rays in superficial psoriatic lesions of the face, the armpits, the genitals and the anal region. (orig.) [de
Prosthetic replacement Head, 3–19 Joints, 3–14g(5) Valve , 3–24a Protozoal infestations, 2–35n Psoriasis, 2–36q, 2–38w Parapsoriasis, 3–38u Psoriatic...832), or knee (836); or instability of any major joint such as shoulder (718.1), elbow (718.3), or hip (718.5). d. Fractures . (1) Malunion or non...union of any fracture (733.8), except ulnar styloid process. (2) Orthopedic hardware (733.99), including plates, pins, rods, wires, or screws used for
Full Text Available We retrospectively analyzed the clinicopathological correlation and prognostic value of cell surface antigens expressed by peripheral blood mononuclear cells in patients with mycosis fungoides (MF. 121 consecutive MF patients were included in this study. All patients had peripheral blood flow cytometry as part of their first visit. TNMB and histopathological staging of the cases were retrospectively performed in accordance with International Society for Cutaneous Lymphomas/European Organization of Research and Treatment of Cancer (ISCL/EORTC criteria at the time of flow cytometry sampling. To determine prognostic value of cell surface antigens, cases were divided into two groups as stable and progressive disease. 17 flow cytometric analyses of 17 parapsoriasis (PP and 11 analyses of 11 benign erythrodermic patients were included as control groups. Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3+, CD4+, CD8+, TCRαβ+, TCRγδ+, CD7+, CD4+CD7+, CD4+CD7−, and CD71+, B cells (HLA-DR+, CD19+, and HLA-DR+CD19+, NKT cells (CD3+CD16+CD56+, and NK cells (CD3−CD16+CD56+. The mean value of all cell surface antigens was not statistically significant between parapsoriasis and MF groups. Along with an increase in cases of MF stage statistically significant difference was found between the mean values of cell surface antigens. Flow cytometric analysis of peripheral blood cell surface antigens in patients with mycosis fungoides may contribute to predicting disease stage and progression.
On the basis of the existing information concerning the character of the Thule accident, the investigations that followed it, and the opinions of key persons involved, the expert group concludes, that the symptoms and the illnesses described among the Thule workers do not originate from exposure to radiation. The expert group however recommends implementation of certain supplementary investigations. The purpose of further examination is to establish a sound and differentiated basis for evaluation of the health complaints presented by the Thule workers after 1986. The expert group considered its foremost task to be the evaluation of the single factors in the entire sequence of events, and an indication of the less extensive and less expensive investigation areas, which could lead to further elucidation. These areas of concern are : the composition of the bomb, the construction specifications of the aircraft involved and composition of its aircraft fuel, the radioactive and non-radioactive exposure of the population, morbidity and mortality (checking of the epidemiological register), the increased rate of parapsoriasis and other dermatological problems, and psychologic factors and psychosomatic stress. These investigations are recommended to be carried out by research sociologists, physicians and psychologists with experience in this field, assisted by a consultant group of international standing, for instance from Norway and USA. (EG) 65 refs
Full Text Available BACKGROUND Papulosquamous lesions form the largest group of skin diseases. Since, they are all characterized by scaling papules or plaques, clinical confusion may result in their diagnosis, hence definitive histopathological analysis is important for their differentiation. MATERIALS AND METHODS The study includes skin biopsies from 108 clinically diagnosed /suspected non-infectious, erythematous, papulosquamous skin diseases which were received in the Department of Pathology, Andhra Medical College, Visakhapatnam for a period of two years from January 2016 to December 2017. The specimens obtained were subjected to formalin fixation and was subjected to routine processing and sections were stained with haematoxylin and eosin (H&E. The lesions were classified as Lichen Planus, Psoriasis, along with rare conditions like Pityriasis Rosea, Parapsoriasis, Pityriasis Rubra Pilaris, Prurigo Nodularis and Lichen Simplex chronicus and clinicopathological correlation was done. RESULTS A total of 108 cases were studied. Lichen planus (51 cases- 47.22% was the most common lesions followed by Psoriasis (34 cases - 31.48% and with majority of cases in the age group of 21 to 30 years (25 cases– 23.15%. Females were more commonly affected with a male to female ratio of 0.89:1. Out of 108 cases, clinicopathological correlation was seen in 68 cases (62.96%. CONCLUSION The importance of specific histopathological diagnosis lies in distinguishing these lesions into different entities as the treatment and prognosis varies widely and is disease-specific.
Gopal Ambadasrao Pandit
Full Text Available Context: Psoriasis affects about 1.5% to 3% of world′s population. Other papulosquamous dermatoses are Pityriasis rosea, Lichen planus, Seborrheic dermatitis, Pityriasis rubra pilaris and Parapsoriasis. Drug eruptions, tinea corporis, and secondary syphilis may also have papulosquamous morphology. Because all papulosquamous disorders are characterized by scaling papules, clinical confusion may result during their diagnosis. Separation of each of these becomes important because the treatment and prognosis for each tends to be disease-specific. Aim: To study the pattern of clinical and histopathological features of psoriasis of the skin with clinicopathological correlation. Material and methods: The present study of 42 cases of psoriasis of the skin was carried out in the Department of Pathology of a tertiary care centre from December 2009 to October 2011. In this study, the patients which were clinically diagnosed as psoriasis of skin, before starting the treatment and attending the outdoor skin department were selected. Histopathological findings were interpreted in light of clinical details. Results: Out of 42 cases of psoriasis 24 (57.14% were males, 18 (42.86% were females with male to female ratio of 1.33:1. Mean age was 34.45 years. Maximum number of cases 22 (52.38% were encountered in 3rd and 4th decade of life. Histopathological findings: parakeratosis, acanthosis, suprapapillary thinning, Munro microabscesses and hypogranulosis were noted in most of the cases. Conclusion: Histopathology serves as a diagnostic tool and rules out other lesions which mimic psoriasis. The most accurate diagnosis is the one that most closely correlates with clinical outcome and helps to direct the most appropriate clinical intervention.
Full Text Available Background and Design: Photodynamic therapy (FDT is a photochemotherapy modality which is used frequently and effectively in the treatment of actinic keratosis, Bowen disease and basal cell carcinomas. This study was performed to determine cure rates, cosmetic outcome and recurrence rates after aminolevulinic acid (ALA-based photodynamic therapy for skin lesions showing complete response to treatment procedure. Material and Method: Sixty-eight patients (27 females and 41 males with 78 lesions were included in the study. Among them, 25 were actinic keratosis (AK, 8 were actinic cheilitis (AC, 30 were basal cell carcinomas (BCC, 3 were Bowen disease, 10 were intraepidermal epithelioma (IEE, one lesion was parapsoriasis and one lesion was verruca plantaris. Six to 8 hours after topical administration of ALA (20%, the lesions were exposed to light from a broad-band light source. Skin biopsy specimens were obtained from 74 lesions for histopathological control. Results: At the end of the second month of treatment, fifty-six (72% of seventy-eight lesions showed complete clinical response, whereas fourty-seven of 74 lesions (63.5% exhibited complete histopathological clearance. A total of 9 recurrences (16% was observed during a median follow-up of 36 months. Recurrence rates were 3 (14% in AK, 1 (17% in AC, 1 (8% in superficial BCC, 3 (75% nodular BCC and 1 (12.5% in IEE. Cosmetic outcome was excellent and good in 42 lesions (89%, fair in 3 lesions (6% and poor in 2 lesions (5%. Conclusion: Topical photodynamic therapy is a noninvasive, effective and cosmetic modality of treatment in the selected skin lesions, as an alternative to the conventional procedures.
Emadi, S. N.; Emadi, S. E.
, parapsoriasis, itching etc) that begun shortly after exposure to SM as mentioned in the first group of long term effects of SM . On the other hand toxicity, mutagenicity and carcinogenicity potentiality of SM as an alkylating agent causes dysfunction in the immune cell systems such as NK cell, cytokines and other growth factors during and after exposure to SM may stimulate CD45, CD45RO, CLA and other T-cell to abnormal activity directly. Finally, chemical weapons are very harmful to life hence blocking of production, prevention of use and immediate treatment and long term follow up of victims are the most important measures to be taken by all scientists
Prevalence study of dermatoses referred to the phototherapy unit at the Dermatology Service of the Clinics Hospital of Porto Alegre, RS, Brazil Estudo de prevalência das dermatoses encaminhadas ao setor de fototerapia do ambulatório de dermatologia do Hospital de Clínicas de Porto Alegre, RS, Brasil
Full Text Available BACKGROUND: Phototherapy consists of exposure to ultraviolet radiation for therapeutic reasons. Radiation is already used in dermatological practice, and many studies have already proved the beneficial effect of UV light treatment for chronic inflammatory or lymphoproliferative skin diseases. The Dermatology Service of the Clinics Hospital of Porto Alegre (Hospital de Clínicas de Porto Alegre has been using phototherapy for a long time, and no official data have been described so far. OBJECTIVES: To study the prevalence of dermatoses referred to the phototherapy unit at the Clinics Hospital of Porto Alegre and describe the total number of patients who have already been referred to this sector and their phototype. METHODS: This is a descriptive cross-sectional study. Data were collected through a review of the phototherapy patients' records (secondary data, which are available on a database of the Dermatology Service of the Clinics Hospital of Porto Alegre, from August 1997 to July 2011. RESULTS: A total of 653 records were analyzed. Phototype 3 was the most prevalent (n=313. Distribution of the prevalence of dermatoses referred to the phototherapy unit was as follows: vitiligo (279, psoriasis (255, cutaneous T-cell lymphoma/mycosis fungoides (29, graftversus-host disease (15, scleroderma (11, atopic dermatitis (10, alopecia areata (6, parapsoriasis (5, eczema (4, granuloma annulare (4, and others (35. As vitiligo and psoriasis were the two most prevalent dermatoses, they were analyzed separately, with no statistical difference in prevalence between them (P=0,177. CONCLUSIONS: Our findings are in accordance with the literature, showing that although phototherapy is still mostly indicated to treat psoriasis, it has been used to treat other dermatoses, since the results are promising. FUNDAMENTOS: Fototerapia é exposição à radiação ultravioleta para uso terapêutico. O uso dessas radiações já é utilizado na prática dermatológica, e