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Sample records for parameter studies heterogeneous

  1. A Study on the Basic Criteria for Selecting Heterogeneity Parameters of F18-FDG PET Images

    Science.gov (United States)

    Forgacs, Attila; Pall Jonsson, Hermann; Dahlbom, Magnus; Daver, Freddie; D. DiFranco, Matthew; Opposits, Gabor; K. Krizsan, Aron; Garai, Ildiko; Czernin, Johannes; Varga, Jozsef; Tron, Lajos; Balkay, Laszlo

    2016-01-01

    Textural analysis might give new insights into the quantitative characterization of metabolically active tumors. More than thirty textural parameters have been investigated in former F18-FDG studies already. The purpose of the paper is to declare basic requirements as a selection strategy to identify the most appropriate heterogeneity parameters to measure textural features. Our predefined requirements were: a reliable heterogeneity parameter has to be volume independent, reproducible, and suitable for expressing quantitatively the degree of heterogeneity. Based on this criteria, we compared various suggested measures of homogeneity. A homogeneous cylindrical phantom was measured on three different PET/CT scanners using the commonly used protocol. In addition, a custom-made inhomogeneous tumor insert placed into the NEMA image quality phantom was imaged with a set of acquisition times and several different reconstruction protocols. PET data of 65 patients with proven lung lesions were retrospectively analyzed as well. Four heterogeneity parameters out of 27 were found as the most attractive ones to characterize the textural properties of metabolically active tumors in FDG PET images. These four parameters included Entropy, Contrast, Correlation, and Coefficient of Variation. These parameters were independent of delineated tumor volume (bigger than 25–30 ml), provided reproducible values (relative standard deviation< 10%), and showed high sensitivity to changes in heterogeneity. Phantom measurements are a viable way to test the reliability of heterogeneity parameters that would be of interest to nuclear imaging clinicians. PMID:27736888

  2. A Study on the Basic Criteria for Selecting Heterogeneity Parameters of F18-FDG PET Images.

    Directory of Open Access Journals (Sweden)

    Attila Forgacs

    Full Text Available Textural analysis might give new insights into the quantitative characterization of metabolically active tumors. More than thirty textural parameters have been investigated in former F18-FDG studies already. The purpose of the paper is to declare basic requirements as a selection strategy to identify the most appropriate heterogeneity parameters to measure textural features. Our predefined requirements were: a reliable heterogeneity parameter has to be volume independent, reproducible, and suitable for expressing quantitatively the degree of heterogeneity. Based on this criteria, we compared various suggested measures of homogeneity. A homogeneous cylindrical phantom was measured on three different PET/CT scanners using the commonly used protocol. In addition, a custom-made inhomogeneous tumor insert placed into the NEMA image quality phantom was imaged with a set of acquisition times and several different reconstruction protocols. PET data of 65 patients with proven lung lesions were retrospectively analyzed as well. Four heterogeneity parameters out of 27 were found as the most attractive ones to characterize the textural properties of metabolically active tumors in FDG PET images. These four parameters included Entropy, Contrast, Correlation, and Coefficient of Variation. These parameters were independent of delineated tumor volume (bigger than 25-30 ml, provided reproducible values (relative standard deviation< 10%, and showed high sensitivity to changes in heterogeneity. Phantom measurements are a viable way to test the reliability of heterogeneity parameters that would be of interest to nuclear imaging clinicians.

  3. Residual waters treatment by heterogeneous photocatalysis: a study of experimental parameters applied to the photoelectrocatalysis

    Directory of Open Access Journals (Sweden)

    Henrique de Santana

    2006-02-01

    Full Text Available In this paper, the use of electrochemically-assisted heterogeneous photo-catalysis will be discussed. Several operational parameters will also be discussed, in order to achieve optimum efficiency of this photo-degradation system, such as: the influence of variables as support electrolyte, applied potential, dye initial concentration, pH and choice of a UV source on dye degradation.

  4. The Power of Heterogeneity: Parameter Relationships from Distributions

    Science.gov (United States)

    Röding, Magnus; Bradley, Siobhan J.; Williamson, Nathan H.; Dewi, Melissa R.; Nann, Thomas; Nydén, Magnus

    2016-01-01

    Complex scientific data is becoming the norm, many disciplines are growing immensely data-rich, and higher-dimensional measurements are performed to resolve complex relationships between parameters. Inherently multi-dimensional measurements can directly provide information on both the distributions of individual parameters and the relationships between them, such as in nuclear magnetic resonance and optical spectroscopy. However, when data originates from different measurements and comes in different forms, resolving parameter relationships is a matter of data analysis rather than experiment. We present a method for resolving relationships between parameters that are distributed individually and also correlated. In two case studies, we model the relationships between diameter and luminescence properties of quantum dots and the relationship between molecular weight and diffusion coefficient for polymers. Although it is expected that resolving complicated correlated relationships require inherently multi-dimensional measurements, our method constitutes a useful contribution to the modelling of quantitative relationships between correlated parameters and measurements. We emphasise the general applicability of the method in fields where heterogeneity and complex distributions of parameters are obstacles to scientific insight. PMID:27182701

  5. Determination of kinetic parameters of heterogeneous isotopic exchange reaction

    International Nuclear Information System (INIS)

    Huang, Ting-Chia; Tsai, Fuan-Nan

    1977-01-01

    A mathematical model has been proposed for a heterogeneous isotopic exchange reaction which involves film diffusion, surface chemical reaction and intraparticle diffusion. The exchange equation to predict the exchange fraction as a function of time for the spherical particles immersed in a solution of finite volume has been derived. The relations between the exchange fraction and dimensionless time are plotted with xi(=ak sub(f)/KD sub(e)), xi 1 (=K 1 a 2 /D sub(e)) and final fractional uptake as parameters. From the values of the kinetic parameters xi and xi 1 , the relative importance of each limiting step is discussed. Experimental results of the isotopic exchange reaction of calcium ion in both system CaCO 3 (s)/Ca 2+ (aq) and system calcium type resin Dowex 50W-X8/Ca 2+ (aq) are coincident with the theoretical equation proposed in this study. (auth.)

  6. Determination of heterogeneous medium parameters by single fuel element method

    International Nuclear Information System (INIS)

    Veloso, M.A.F.

    1985-01-01

    The neutron pulse propagation technique was employed to study an heterogeneous system consisting of a single fuel element placed at the symmetry axis of a large cylindrical D 2 O tank. The response of system for the pulse propagation technique is related to the inverse complex relaxation length of the neutron waves also known as the system dispersion law ρ (ω). Experimental values of ρ (ω) were compared with the ones derived from Fermi age - Diffusion theory. The main purpose of the experiment was to obtain the Feinberg-Galanin thermal constant (γ), which is the logaritmic derivative of the neutron flux at the fuel-moderator interface and a such a main input data for heterogeneous reactor theory calculations. The γ thermal constant was determined as the number giving the best agreement between the theoretical and experimental values of ρ (ω). The simultaneous determination of two among four parameters η,ρ,τ and L s is possible through the intersection of dispersion laws of the pure moderator system and the fuel moderator system. The parameters τ and η were termined by this method. It was shown that the thermal constant γ and the product η ρ can be computed from the real and imaginary parts of the fuel-moderator dispersion law. The results for this evaluation scheme showns a not stable behavior of γ as a function of frequency, a result not foreseen by the theoretical model. (Author) [pt

  7. Characterization of unsaturated hydraulic parameters for homogeneous and heterogeneous soils

    Energy Technology Data Exchange (ETDEWEB)

    Wildenschild, Dorthe

    1997-09-01

    Application of numerical models for predicting future spreading of contaminants into ground water aquifers is dependent on appropriate characterization of the soil hydraulic properties controlling flow and transport in the unsaturated zone. This thesis reviews the current knowledge on two aspects of characterization of unsaturated hydraulic parameters; estimation of the basic hydraulic parameters for homogeneous soils and statistical representation of heterogeneity for spatially variable soils. The retention characteristic is traditionally measured using steady-state procedures, but new ideas based on dynamic techniques have been developed that reduce experimental efforts and that produce retention curves which compare to those measured by traditional techniques. The unsaturated hydraulic conductivity is difficult to establish by steady-state procedures, and extensive research efforts have been focused on alternative methods that are based on inverse estimation. The inverse methods have commonly been associated with problems of numerical instability and ill-posedness of the parameter estimates, but recent investigations have shown that the uniqueness of parameter estimates can be improved by including additional, independent information on, for instance, the retention characteristic. Also, uniqueness may be improved by careful selection of experimental conditions are parametric functions. (au) 234 refs.

  8. Evaluation of Hydraulic Parameters Obtained by Different Measurement Methods for Heterogeneous Gravel Soil

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    Chen Zeng

    2012-01-01

    Full Text Available Knowledge of soil hydraulic parameters for the van Genuchten function is important to characterize soil water movement for watershed management. Accurate and rapid prediction of soil water flow in heterogeneous gravel soil has become a hot topic in recent years. However, it is difficult to precisely estimate hydraulic parameters in a heterogeneous soil with rock fragments. In this study, the HYDRUS-2D numerical model was used to evaluate hydraulic parameters for heterogeneous gravel soil that was irregularly embedded with rock fragments in a grape production base. The centrifugal method (CM, tensiometer method (TM and inverse solution method (ISM were compared for various parameters in the van Genuchten function. The soil core method (SCM, disc infiltration method (DIM and inverse solution method (ISM were also investigated for measuring saturated hydraulic conductivity. Simulation with the DIM approach revealed a problem of overestimating soil water infiltration whereas simulation with the SCM approach revealed a problem of underestimating water movement as compared to actual field observation. The ISM approach produced the best simulation result even though this approach slightly overestimated soil moisture by ignoring the impact of rock fragments. This study provides useful information on the overall evaluation of soil hydraulic parameters attained with different measurement methods for simulating soil water movement and distribution in heterogeneous gravel soil.

  9. CHARACTERIZING LANDSCAPE SPATIAL HETEROGENEITY USING SEMIVARIOGRAM PARAMETERS DERIVED FROM NDVI IMAGES

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    Eduarda Martiniano de Oliveira Silveira

    2017-12-01

    Full Text Available Assuming a relationship between landscape heterogeneity and measures of spatial dependence by using remotely sensed data, the aim of this work was to evaluate the potential of semivariogram parameters, derived from satellite images with different spatial resolutions, to characterize landscape spatial heterogeneity of forested and human modified areas. The NDVI (Normalized Difference Vegetation Index was generated in an area of Brazilian amazon tropical forest (1,000 km².We selected samples (1 x 1 km from forested and human modified areas distributed throughout the study area, to generate the semivariogram and extract the sill (σ²-overall spatial variability of the surface property and range (φ-the length scale of the spatial structures of objects parameters. The analysis revealed that image spatial resolution influenced the sill and range parameters. The average sill and range values increase from forested to human modified areas and the greatest between-class variation was found for LANDSAT 8 imagery, indicating that this image spatial resolution is the most appropriate for deriving sill and range parameters with the intention of describing landscape spatial heterogeneity. By combining remote sensing and geostatistical techniques, we have shown that the sill and range parameters of semivariograms derived from NDVI images are a simple indicator of landscape heterogeneity and can be used to provide landscape heterogeneity maps to enable researchers to design appropriate sampling regimes. In the future, more applications combining remote sensing and geostatistical features should be further investigated and developed, such as change detection and image classification using object-based image analysis (OBIA approaches.

  10. Rate tracer studies of heterogeneous catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Happel, J; Kiang, S

    1977-10-01

    An analysis is presented of the extent to which parameters involved in transient tracing of isotopic species in heterogeneous catalysis can be determined by experiments in which tracer concentrations are measured as a function of time. Different treatments for open and closed systems with the over-all reaction at equilibrium or irreversible were developed.

  11. Hydraulic Parameter Generation Technique Using a Discrete Fracture Network with Bedrock Heterogeneity in Korea

    Directory of Open Access Journals (Sweden)

    Jae-Yeol Cheong

    2017-12-01

    Full Text Available In instances of damage to engineered barriers containing nuclear waste material, surrounding bedrock is a natural barrier that retards radionuclide movement by way of adsorption and delay due to groundwater flow through highly tortuous fractured rock pathways. At the Gyeongju nuclear waste disposal site, groundwater mainly flows through granitic and sedimentary rock fractures. Therefore, to understand the nuclide migration path, it is necessary to understand discrete fracture networks based on heterogeneous fracture orientations, densities, and size characteristics. In this study, detailed heterogeneous fracture distribution, including the density and orientation of the fractures, was considered for a region that has undergone long periods of change from various geological activities at and around the Gyeongju site. A site-scale discrete fracture network (DFN model was constructed taking into account: (i regional fracture heterogeneity constrained by a multiple linear regression analysis of fracture intensity on faults and electrical resistivity; and (ii the connectivity of conductive fractures having fracture hydraulic parameters, using transient flow simulation. Geometric and hydraulic heterogeneity of the DFN was upscaled into equivalent porous media for flow and transport simulation for a large-scale model.

  12. NERON-Computing system for PHWR reactor cells and heterogeneous parameter calculations

    International Nuclear Information System (INIS)

    Cristian, I.; Cirstoiu, B.; Slavnicu, S.D.

    1976-04-01

    A system of codes for PHWR type reactors is presented. The system includes the cell code NERO and a code PARETE for monopolar and dipolar heterogeneous calculations. A general theory of dipolar flux is necessary for a more accurate evaluation of void coefficient and diffusion moderator coefficient is given. The determination of monopolar and dipolar heterogeneous parameters is very useful for heterogeneous methods developped especially for HWR reactors during the last years. (author)

  13. Analytic Investigation Into Effect of Population Heterogeneity on Parameter Ratio Estimates

    International Nuclear Information System (INIS)

    Schinkel, Colleen; Carlone, Marco; Warkentin, Brad; Fallone, B. Gino

    2007-01-01

    Purpose: A homogeneous tumor control probability (TCP) model has previously been used to estimate the α/β ratio for prostate cancer from clinical dose-response data. For the ratio to be meaningful, it must be assumed that parameter ratios are not sensitive to the type of tumor control model used. We investigated the validity of this assumption by deriving analytic relationships between the α/β estimates from a homogeneous TCP model, ignoring interpatient heterogeneity, and those of the corresponding heterogeneous (population-averaged) model that incorporated heterogeneity. Methods and Materials: The homogeneous and heterogeneous TCP models can both be written in terms of the geometric parameters D 50 and γ 50 . We show that the functional forms of these models are similar. This similarity was used to develop an expression relating the homogeneous and heterogeneous estimates for the α/β ratio. The expression was verified numerically by generating pseudo-data from a TCP curve with known parameters and then using the homogeneous and heterogeneous TCP models to estimate the α/β ratio for the pseudo-data. Results: When the dominant form of interpatient heterogeneity is that of radiosensitivity, the homogeneous and heterogeneous α/β estimates differ. This indicates that the presence of this heterogeneity affects the value of the α/β ratio derived from analysis of TCP curves. Conclusions: The α/β ratio estimated from clinical dose-response data is model dependent-a heterogeneous TCP model that accounts for heterogeneity in radiosensitivity will produce a greater α/β estimate than that resulting from a homogeneous TCP model

  14. Program for parameter studies of steam generators

    International Nuclear Information System (INIS)

    Mathisen, R.P.

    1982-11-01

    R2-GEN is a computer code for stationary thermal parameter studies of steam generators. The geometry and data are valid for Ringhals-2 generators. Subroutines and relevant calculations are included. The program is based on a heterogeneous flow model and some applications on tubes with varying contamination are presented. (G.B.)

  15. ATLAS parameter study

    International Nuclear Information System (INIS)

    Adler, R.J.

    1994-01-01

    The purpose of this study is to make an independent assessment on the parameters chosen for the ATLAS capacitor bank at LANL. The contractor will perform a study of the basic pulsed power parameters of the ATLAS device with baseline functional parameters of >25 MA implosion current and <2.5 microsecond current risetime. Nominal circuit parameters held fixed will be the 14 nH from the vacuum interface to the load, and the nominal load impedances of 1 milliohm for slow loads and 10 milliohms for fast loads. Single Ended designs, as opposed to bipolar designs, will be studied in detail. The ATLAS pulsed power design problem is about inductance. The reason that a 36 MJ bank is required is that such a bank has enough individual capacitors so that the parallel inductance is acceptably low. Since about half the inductance is in the bank, and the inductance and time constant of the submodules is fixed, the variation of output with a given parameter will generally be a weak one. In general, the dl/dt calculation demonstrates that for the real system inductances, 700 kV is the optimum voltage for the bank to drive X-ray loads. The optimum is broad, and there is little reduction in performance at voltages as low as 450 kV. The direct drive velocity analysis also shows that the optimum velocity is between 480 and 800 kV for a variety of assumptions, and that there is less than a 10% variation in velocity over this range. Voltages in the 120 kV--600 kV range are desirable for driving heavy liners. A compromise optimum operating point might be 480 kV, at which all X-ray operation scenarios are within 10% of their velocity optimum, and heavy liners can be configured to be near optimum if small enough. Based on very preliminary studies the author believes that the choice of a single operating voltage point (say, 480 kV) is unnecessary, and that a bank engineered for dual operation at 480 and 240 kV will be the best solution to the ATLAS problem

  16. Optimization of light source parameters in the photodynamic therapy of heterogeneous prostate

    International Nuclear Information System (INIS)

    Li Jun; Altschuler, Martin D; Hahn, Stephen M; Zhu, Timothy C

    2008-01-01

    results from heterogeneous optical data with those obtained from average homogeneous optical properties. The optimized treatment plans are also compared with the reference clinical plan, defined as the plan with sources of equal strength, distributed regularly in space, which delivers a mean value of prescribed fluence at detector locations within the treatment region. The study suggests that comprehensive optimization of source parameters (i.e. strengths, lengths and locations) is feasible, thus allowing acceptable dose coverage in a heterogeneous prostate PDT within the time constraints of the PDT procedure

  17. Observed and Unobserved Heterogeneity in the Duration Dependency Parameter

    DEFF Research Database (Denmark)

    Rosholm, Michael

    2000-01-01

    We present a duration model, which allows for non-homogenous duration dependence with respect to observed and unobserved variables. The model is examined in a simulation study, and it is estimated on unemployment spells of a sample of Danish workers. Udgivelsesdato: MAR......We present a duration model, which allows for non-homogenous duration dependence with respect to observed and unobserved variables. The model is examined in a simulation study, and it is estimated on unemployment spells of a sample of Danish workers. Udgivelsesdato: MAR...

  18. [Temporal and spatial heterogeneity analysis of optimal value of sensitive parameters in ecological process model: The BIOME-BGC model as an example.

    Science.gov (United States)

    Li, Yi Zhe; Zhang, Ting Long; Liu, Qiu Yu; Li, Ying

    2018-01-01

    The ecological process models are powerful tools for studying terrestrial ecosystem water and carbon cycle at present. However, there are many parameters for these models, and weather the reasonable values of these parameters were taken, have important impact on the models simulation results. In the past, the sensitivity and the optimization of model parameters were analyzed and discussed in many researches. But the temporal and spatial heterogeneity of the optimal parameters is less concerned. In this paper, the BIOME-BGC model was used as an example. In the evergreen broad-leaved forest, deciduous broad-leaved forest and C3 grassland, the sensitive parameters of the model were selected by constructing the sensitivity judgment index with two experimental sites selected under each vegetation type. The objective function was constructed by using the simulated annealing algorithm combined with the flux data to obtain the monthly optimal values of the sensitive parameters at each site. Then we constructed the temporal heterogeneity judgment index, the spatial heterogeneity judgment index and the temporal and spatial heterogeneity judgment index to quantitatively analyze the temporal and spatial heterogeneity of the optimal values of the model sensitive parameters. The results showed that the sensitivity of BIOME-BGC model parameters was different under different vegetation types, but the selected sensitive parameters were mostly consistent. The optimal values of the sensitive parameters of BIOME-BGC model mostly presented time-space heterogeneity to different degrees which varied with vegetation types. The sensitive parameters related to vegetation physiology and ecology had relatively little temporal and spatial heterogeneity while those related to environment and phenology had generally larger temporal and spatial heterogeneity. In addition, the temporal heterogeneity of the optimal values of the model sensitive parameters showed a significant linear correlation

  19. Statistical parameters of random heterogeneity estimated by analysing coda waves based on finite difference method

    Science.gov (United States)

    Emoto, K.; Saito, T.; Shiomi, K.

    2017-12-01

    Short-period (2 s) seismograms. We found that the energy of the coda of long-period seismograms shows a spatially flat distribution. This phenomenon is well known in short-period seismograms and results from the scattering by small-scale heterogeneities. We estimate the statistical parameters that characterize the small-scale random heterogeneity by modelling the spatiotemporal energy distribution of long-period seismograms. We analyse three moderate-size earthquakes that occurred in southwest Japan. We calculate the spatial distribution of the energy density recorded by a dense seismograph network in Japan at the period bands of 8-16 s, 4-8 s and 2-4 s and model them by using 3-D finite difference (FD) simulations. Compared to conventional methods based on statistical theories, we can calculate more realistic synthetics by using the FD simulation. It is not necessary to assume a uniform background velocity, body or surface waves and scattering properties considered in general scattering theories. By taking the ratio of the energy of the coda area to that of the entire area, we can separately estimate the scattering and the intrinsic absorption effects. Our result reveals the spectrum of the random inhomogeneity in a wide wavenumber range including the intensity around the corner wavenumber as P(m) = 8πε2a3/(1 + a2m2)2, where ε = 0.05 and a = 3.1 km, even though past studies analysing higher-frequency records could not detect the corner. Finally, we estimate the intrinsic attenuation by modelling the decay rate of the energy. The method proposed in this study is suitable for quantifying the statistical properties of long-wavelength subsurface random inhomogeneity, which leads the way to characterizing a wider wavenumber range of spectra, including the corner wavenumber.

  20. Pharmacogenomics Bias - Systematic distortion of study results by genetic heterogeneity

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    Zietemann, Vera

    2008-04-01

    Full Text Available Background: Decision analyses of drug treatments in chronic diseases require modeling the progression of disease and treatment response beyond the time horizon of clinical or epidemiological studies. In many such models, progression and drug effect have been applied uniformly to all patients; heterogeneity in progression, including pharmacogenomic effects, has been ignored. Objective: We sought to systematically evaluate the existence, direction and relative magnitude of a pharmacogenomics bias (PGX-Bias resulting from failure to adjust for genetic heterogeneity in both treatment response (HT and heterogeneity in progression of disease (HP in decision-analytic studies based on clinical study data. Methods: We performed a systematic literature search in electronic databases for studies regarding the effect of genetic heterogeneity on the validity of study results. Included studies have been summarized in evidence tables. In the case of lacking evidence from published studies we sought to perform our own simulation considering both HT and HP. We constructed two simple Markov models with three basic health states (early-stage disease, late-stage disease, dead, one adjusting and the other not adjusting for genetic heterogeneity. Adjustment was done by creating different disease states for presence (G+ and absence (G- of a dichotomous genetic factor. We compared the life expectancy gains attributable to treatment resulting from both models and defined pharmacogenomics bias as percent deviation of treatment-related life expectancy gains in the unadjusted model from those in the adjusted model. We calculated the bias as a function of underlying model parameters to create generic results. We then applied our model to lipid-lowering therapy with pravastatin in patients with coronary atherosclerosis, incorporating the influence of two TaqIB polymorphism variants (B1 and B2 on progression and drug efficacy as reported in the DNA substudy of the REGRESS

  1. Ultrasound scatter in heterogeneous 3D microstructures: Parameters affecting multiple scattering

    Science.gov (United States)

    Engle, B. J.; Roberts, R. A.; Grandin, R. J.

    2018-04-01

    This paper reports on a computational study of ultrasound propagation in heterogeneous metal microstructures. Random spatial fluctuations in elastic properties over a range of length scales relative to ultrasound wavelength can give rise to scatter-induced attenuation, backscatter noise, and phase front aberration. It is of interest to quantify the dependence of these phenomena on the microstructure parameters, for the purpose of quantifying deleterious consequences on flaw detectability, and for the purpose of material characterization. Valuable tools for estimation of microstructure parameters (e.g. grain size) through analysis of ultrasound backscatter have been developed based on approximate weak-scattering models. While useful, it is understood that these tools display inherent inaccuracy when multiple scattering phenomena significantly contribute to the measurement. It is the goal of this work to supplement weak scattering model predictions with corrections derived through application of an exact computational scattering model to explicitly prescribed microstructures. The scattering problem is formulated as a volume integral equation (VIE) displaying a convolutional Green-function-derived kernel. The VIE is solved iteratively employing FFT-based con-volution. Realizations of random microstructures are specified on the micron scale using statistical property descriptions (e.g. grain size and orientation distributions), which are then spatially filtered to provide rigorously equivalent scattering media on a length scale relevant to ultrasound propagation. Scattering responses from ensembles of media representations are averaged to obtain mean and variance of quantities such as attenuation and backscatter noise levels, as a function of microstructure descriptors. The computational approach will be summarized, and examples of application will be presented.

  2. A quantitative geologic study of heterogeneity

    International Nuclear Information System (INIS)

    Davis, J.M.; Phillips, F.M.

    1990-01-01

    Spatial variation of hydraulic conductivity has been generally recognized as the dominant medium-dependent control on the transport and dispersion of contaminants in ground water. An empirical study focusing on the relationship between patters of sedimentology and patterns of permeability is being conducted at an outcrop of the Pliocene/Pleistocene Sierra Ladrones formation, central New Mexico. Methods of geostatistics and sedimentary basin analysis are employed to study the problem of aquifer heterogeneity. An air permeameter provides a means of obtaining extensive field measurements of air-flow rates through the sediments. These flow rates are subsequently used to characterize the permeability distribution of the outcrop. Both the geologic information and the air-flow rate data provide the basis for analysis of aquifer heterogeneity. Preliminary geologic mapping indicates that the sediments in the study area are the products of an arid fluvial/interfluvial depositional environment. Probability distribution analysis of the air-flow rate data suggests that the permeability of these sediments is log-normally distributed. The air permeability data are used to estimate variograms and correlation lengths in both the horizontal and vertical directions. At the scale of 10's of centimeters, the horizontal variograms exhibit exponential variogram behaviour . When two distinct lithologies are present, the correlation structure appears to be a nested exponential. Variogram analysis of estimated mean permeability at the scale of meters also shows evidence of a nested correlation structure in the horizontal direction and a periodic correlation structure in the vertical direction. Results of this study suggest that there is a direct connection between observable geologic structure and permeability statistics. (Author) (35 refs., 10 figs., 5 tabs.)

  3. Heterogeneous distributed databases: A case study

    Science.gov (United States)

    Stewart, Tracy R.; Mukkamala, Ravi

    1991-01-01

    Alternatives are reviewed for accessing distributed heterogeneous databases and a recommended solution is proposed. The current study is limited to the Automated Information Systems Center at the Naval Sea Combat Systems Engineering Station at Norfolk, VA. This center maintains two databases located on Digital Equipment Corporation's VAX computers running under the VMS operating system. The first data base, ICMS, resides on a VAX11/780 and has been implemented using VAX DBMS, a CODASYL based system. The second database, CSA, resides on a VAX 6460 and has been implemented using the ORACLE relational database management system (RDBMS). Both databases are used for configuration management within the U.S. Navy. Different customer bases are supported by each database. ICMS tracks U.S. Navy ships and major systems (anti-sub, sonar, etc.). Even though the major systems on ships and submarines have totally different functions, some of the equipment within the major systems are common to both ships and submarines.

  4. Using Mathematical Modeling Methods for Estimating Entrance Flow Heterogeneity Impact on Aviation GTE Parameters and Performances

    Directory of Open Access Journals (Sweden)

    Yu. A. Ezrokhi

    2017-01-01

    Full Text Available The paper considers methodological approaches to the mathematical models (MM of various levels, dedicated to estimate an impact of the entrance flow heterogeneity on the main parameters and performances of the aviation GTE and it units. By an example of calculation of a twin-shaft turbofan engine in cruiser mode, demonstrates engineering mathematical model capabilities to define the impact of the total pressure field distortion on engine trust and air flow parameters, and also gas dynamic stability margin of the both compressors.It is shown that the presented first level mathematical model allows us to estimate sufficiently the impact of entrance total pressure heterogeneity on the engine parameters. Here reliability of calculations is proved to be true by their comparison with the results, obtained owing to well fulfilled 2D & 3D mathematical models of the engine, which have been repeatedly identified by the results of experiments.It is shown that received results including those on decreasing values of stability margin of both compressors can be used for tentative estimates when choosing a desirable stability margin, providing steady operation of compressors and engine in an entire range of its operating modes. Carrying out a definitive testing calculation using the specialized engine MM of a higher level will not only confirm the results obtained, but also reduce their expected error with regard to the real values reached as a result of tests.

  5. Probing water motion in heterogenous systems : a multi-parameter NMR approach

    NARCIS (Netherlands)

    Dusschoten, van D.

    1996-01-01


    In this Thesis a practical approach is presented to study water mobility in heterogeneous systems by a number of novel NMR sequences. The major part of this Thesis describes how the reliability of diffusion measurements can be improved using some of the novel NMR sequences. The

  6. Revealing additional preference heterogeneity with an extended random parameter logit model: the case of extra virgin olive oil

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    Ahmed Yangui

    2014-07-01

    Full Text Available Methods that account for preference heterogeneity have received a significant amount of attention in recent literature. Most of them have focused on preference heterogeneity around the mean of the random parameters, which has been specified as a function of socio-demographic characteristics. This paper aims at analyzing consumers’ preferences towards extra-virgin olive oil in Catalonia using a methodological framework with two novelties over past studies: 1 it accounts for both preference heterogeneity around the mean and the variance; and 2 it considers both socio-demographic characteristics of consumers as well as their attitudinal factors. Estimated coefficients and moments of willingness to pay (WTP distributions are compared with those obtained from alternative Random Parameter Logit (RPL models. Results suggest that the proposed framework increases the goodness-of-fit and provides more useful insights for policy analysis. The most important attributes affecting consumers’ preferences towards extra virgin olive oil are the price and the product’s origin. The consumers perceive the organic olive oil attribute negatively, as they think that it is not worth paying a premium for a product that is healthy in nature.

  7. Airborne-Measured Spatially-Averaged Temperature and Moisture Turbulent Structure Parameters Over a Heterogeneous Surface

    Science.gov (United States)

    Platis, Andreas; Martinez, Daniel; Bange, Jens

    2014-05-01

    Turbulent structure parameters of temperature and humidity can be derived from scintillometer measurements along horizontal paths of several 100 m to several 10 km. These parameters can be very useful to estimate the vertical turbulent heat fluxes at the surface (applying MOST). However, there are many assumptions required by this method which can be checked using in situ data, e.g. 1) Were CT2 and CQ2 correctly derived from the initial CN2 scintillometer data (structure parameter of density fluctuations or refraction index, respectively)? 2) What is the influence of the surround hetereogeneous surface regarding its footprint and the weighted averaging effect of the scintillometer method 3) Does MOST provide the correct turbulent fluxes from scintillometer data. To check these issues, in situ data from low-level flight measurements are well suited, since research aircraft cover horizontal distances in very short time (Taylor's hypothesis of a frozen turbulence structure can be applyed very likely). From airborne-measured time series the spatial series are calculated and then their structure functions that finally provide the structure parameters. The influence of the heterogeneous surface can be controlled by the definition of certain moving-average window sizes. A very useful instrument for this task are UAVs since they can fly very low and maintain altitude very precisely. However, the data base of such unmanned operations is still quite thin. So in this contribution we want to present turbulence data obtained with the Helipod, a turbulence probe hanging below a manned helicopter. The structure parameters of temperature and moisture, CT2 and CQ2, in the lower convective boundary layer were derived from data measured using the Helipod in 2003. The measurements were carried out during the LITFASS03 campaign over a heterogeneous land surface around the boundary-layer field site of the Lindenberg Meteorological Observatory-Richard-Aßmann-Observatory (MOL) of the

  8. A Generalized Estimating Equations Approach to Model Heterogeneity and Time Dependence in Capture-Recapture Studies

    Directory of Open Access Journals (Sweden)

    Akanda Md. Abdus Salam

    2017-03-01

    Full Text Available Individual heterogeneity in capture probabilities and time dependence are fundamentally important for estimating the closed animal population parameters in capture-recapture studies. A generalized estimating equations (GEE approach accounts for linear correlation among capture-recapture occasions, and individual heterogeneity in capture probabilities in a closed population capture-recapture individual heterogeneity and time variation model. The estimated capture probabilities are used to estimate animal population parameters. Two real data sets are used for illustrative purposes. A simulation study is carried out to assess the performance of the GEE estimator. A Quasi-Likelihood Information Criterion (QIC is applied for the selection of the best fitting model. This approach performs well when the estimated population parameters depend on the individual heterogeneity and the nature of linear correlation among capture-recapture occasions.

  9. Process Parameters Optimization of Potential SO42-/ZnO Acid Catalyst for Heterogeneous Transesterification of Vegetable Oil to Biodiesel

    Directory of Open Access Journals (Sweden)

    Istadi Istadi

    2012-12-01

    Full Text Available Among the possible renewable energy resources, diesel fuels derived from triglycerides of vegetable oils and animal fats have shown potential as substitutes for petroleum-based diesel fuels. The biodiesel could be produced from vegetable oils over homogeneous catalyst, heterogeneous catalyst, or enzymatic catalyst. In this study, the synthesized SO42-/ZnO catalyst was explored to be used in the heterogeneous biodiesel production by using the vegetable oils and methanol. The study began with the preparation of SO42-/ZnO catalyst followed by the transesterification reaction between vegetable oil with methanol. The independent variables (reaction time and the weight ratio of catalyst/oil were optimized to obtain the optimum biodiesel (fatty acid methyl ester yield. The results of this study showed that the acid catalyst SO42-/ZnO was potential to be used as catalyst for biodiesel production through heterogeneous transesterification of vegetable oils. Optimum operating condition for this catalytic reaction was the weight ratio of catalyst/oil of 8:1 and reaction time of 2.6 h with respect to 75.5% yield of methyl ester products. The biodiesel product was also characterized to identify the respected fatty acid methyl ester components. Copyright © 2012 by BCREC UNDIP. All rights reserved. (Selected Paper from International Conference on Chemical and Material Engineering (ICCME 2012Received: 23rd October 2012, Revised: 25th November 2012, Accepted: 25th November 2012[How to Cite: I. Istadi, Didi D. Anggoro, Luqman Buchori, Inshani Utami, Roikhatus Solikhah, (2012. Process Parameters Optimization of Potential SO42-/ZnO Acid Catalyst for Heterogeneous Transesterification of Vegetable Oil to Biodiesel. Bulletin of Chemical Reaction Engineering & Catalysis, 7(2: 150-157. (doi:10.9767/bcrec.7.2.4064.150-157][How to Link / DOI: http://dx.doi.org/10.9767/bcrec.7.2.4064.150-157 ] | View in 

  10. Determination of the criticality parameters in heterogeneous Slab by the LTS{sub N} method

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Volnei [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Dept. de Engenharia Nuclear; Derivi, Alexandre Guimaraes [Universidade Regional Integrada (URI), Erechim, RS (Brazil)

    2001-07-01

    The goal of this work consists in the use of the LTS{sub N} method in criticality problems. This method consists basically in the application of the Laplace Transform to a system of ordinary differential equations generated by the SN approach, resulting in a system of symbolic algebraic equations dependent on the complex parameters. After solving the algebraic system by means of the Schurr and diagonalization methods, the angular fluxes are obtained performing the inverse Laplace transform, which is carried out using the Heaviside formula. This methodology is used in determination of K{sub eff}, critical thickness and the atomic density for a heterogeneous planar slab. This procedure leads the solution of eigenvalue problem to the solution of a transcendental equation. Numerical results are reported. (author)

  11. Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Approach for tuning algorithm parameters

    Science.gov (United States)

    Mueller, Jenna L.; Harmany, Zachary T.; Mito, Jeffrey K.; Kennedy, Stephanie A.; Kim, Yongbaek; Dodd, Leslie; Geradts, Joseph; Kirsch, David G.; Willett, Rebecca M.; Brown, J. Quincy; Ramanujam, Nimmi

    2013-02-01

    The combination of fluorescent contrast agents with microscopy is a powerful technique to obtain real time images of tissue histology without the need for fixing, sectioning, and staining. The potential of this technology lies in the identification of robust methods for image segmentation and quantitation, particularly in heterogeneous tissues. Our solution is to apply sparse decomposition (SD) to monochrome images of fluorescently-stained microanatomy to segment and quantify distinct tissue types. The clinical utility of our approach is demonstrated by imaging excised margins in a cohort of mice after surgical resection of a sarcoma. Representative images of excised margins were used to optimize the formulation of SD and tune parameters associated with the algorithm. Our results demonstrate that SD is a robust solution that can advance vital fluorescence microscopy as a clinically significant technology.

  12. Determination of the criticality parameters in heterogeneous Slab by the LTSN method

    International Nuclear Information System (INIS)

    Borges, Volnei

    2001-01-01

    The goal of this work consists in the use of the LTS N method in criticality problems. This method consists basically in the application of the Laplace Transform to a system of ordinary differential equations generated by the SN approach, resulting in a system of symbolic algebraic equations dependent on the complex parameters. After solving the algebraic system by means of the Schurr and diagonalization methods, the angular fluxes are obtained performing the inverse Laplace transform, which is carried out using the Heaviside formula. This methodology is used in determination of K eff , critical thickness and the atomic density for a heterogeneous planar slab. This procedure leads the solution of eigenvalue problem to the solution of a transcendental equation. Numerical results are reported. (author)

  13. Influence of friction stir welding parameters on titanium-aluminum heterogeneous lap joining configuration

    Science.gov (United States)

    Picot, Florent; Gueydan, Antoine; Hug, Éric

    2017-10-01

    Lap joining configuration for Friction Stir Welding process is a methodology mostly dedicated to heterogeneous bonding. This welding technology was applied to join pure titanium with pure aluminum by varying the rotation speed and the movement speed of the tool. Regardless of the process parameters, it was found that the maximum strength of the junction remains almost constant. Microstructural observations by means of Scanning Electron Microscopy and Energy Dispersive Spectrometry analysis enable to describe the interfacial join and reveal asymmetric Cold Lap Defects on the sides of the junction. Chemical analysis shows the presence of one exclusive intermetallic compound through the interface identified as TiAl3. This compound is responsible of the crack spreading of the junction during the mechanical loading. The original version of this article supplied to AIP Publishing contained an accidental inversion of the authors, names. An updated version of this article, with the authors names formatted correctly was published on 20 October 2017.

  14. Determination of criticality parameters in heterogeneous planar slabs by LTSN method

    International Nuclear Information System (INIS)

    Borges, Volnei

    2000-01-01

    The goal of this work consists in the used the LTS N method in criticality problems. This method consists basically in the application of the Laplace Transform in the system of ordinary differential equations generated by the S N approach, resulting in a system of symbolic algebraic equations dependents on the complex parameters. This system is solved and, then the solution is reconstructed by the inverse of the transformed of Laplace using the Schurr and diagonalization methods and the technique of expansion of Heaviside. This methodology is used in determination of K eff , critical thickness and the atomic density for a heterogeneous planar slab. This procedure leads to the solution of eigenvalue problem to the solution of a transcendental equation. Numerical results are reported. (author)

  15. Kinetic study of the hydration of propylene oxide in the presence of heterogeneous catalyst

    Directory of Open Access Journals (Sweden)

    Akyalcin Sema

    2017-01-01

    Full Text Available The kinetics of the hydration of propylene oxide was studied using a pressurized batch reactor for both uncatalyzed and heterogeneously catalyzed reactions. Lewatit MonoPlus M500/HCO3 - was used as heterogeneous catalyst, which showed better performance than Dowex Marathon A/HCO3 -. The effects of the parameters, namely internal and external diffusion resistances, temperature, catalyst loading and mole ratios of reactants, on the reaction rate were studied. The uncatalyzed and heterogeneously catalyzed reactions were proven to follow a series-parallel irreversible homogeneous mechanism. The temperature dependencies of the rate constants appearing in the rate expressions were determined.

  16. Estimation of Transport Parameters Using Forced Gradient Tracer Tests in Heterogeneous Aquifers

    National Research Council Canada - National Science Library

    Illangasekare, Tissa

    2003-01-01

    .... The focus was on both reactive and sorptive parameters. The experimental component of the study was conducted in a three-dimensional, intermediate-scale test tank to obtain accurate data on the behavior of nonreactive and sorptive tracers...

  17. SCS-CN parameter determination using rainfall-runoff data in heterogeneous watersheds - the two-CN system approach

    Science.gov (United States)

    Soulis, K. X.; Valiantzas, J. D.

    2012-03-01

    The Soil Conservation Service Curve Number (SCS-CN) approach is widely used as a simple method for predicting direct runoff volume for a given rainfall event. The CN parameter values corresponding to various soil, land cover, and land management conditions can be selected from tables, but it is preferable to estimate the CN value from measured rainfall-runoff data if available. However, previous researchers indicated that the CN values calculated from measured rainfall-runoff data vary systematically with the rainfall depth. Hence, they suggested the determination of a single asymptotic CN value observed for very high rainfall depths to characterize the watersheds' runoff response. In this paper, the hypothesis that the observed correlation between the calculated CN value and the rainfall depth in a watershed reflects the effect of soils and land cover spatial variability on its hydrologic response is being tested. Based on this hypothesis, the simplified concept of a two-CN heterogeneous system is introduced to model the observed CN-rainfall variation by reducing the CN spatial variability into two classes. The behaviour of the CN-rainfall function produced by the simplified two-CN system is approached theoretically, it is analysed systematically, and it is found to be similar to the variation observed in natural watersheds. Synthetic data tests, natural watersheds examples, and detailed study of two natural experimental watersheds with known spatial heterogeneity characteristics were used to evaluate the method. The results indicate that the determination of CN values from rainfall runoff data using the proposed two-CN system approach provides reasonable accuracy and it over performs the previous methods based on the determination of a single asymptotic CN value. Although the suggested method increases the number of unknown parameters to three (instead of one), a clear physical reasoning for them is presented.

  18. SCS-CN parameter determination using rainfall-runoff data in heterogeneous watersheds – the two-CN system approach

    Directory of Open Access Journals (Sweden)

    J. D. Valiantzas

    2012-03-01

    Full Text Available The Soil Conservation Service Curve Number (SCS-CN approach is widely used as a simple method for predicting direct runoff volume for a given rainfall event. The CN parameter values corresponding to various soil, land cover, and land management conditions can be selected from tables, but it is preferable to estimate the CN value from measured rainfall-runoff data if available. However, previous researchers indicated that the CN values calculated from measured rainfall-runoff data vary systematically with the rainfall depth. Hence, they suggested the determination of a single asymptotic CN value observed for very high rainfall depths to characterize the watersheds' runoff response. In this paper, the hypothesis that the observed correlation between the calculated CN value and the rainfall depth in a watershed reflects the effect of soils and land cover spatial variability on its hydrologic response is being tested. Based on this hypothesis, the simplified concept of a two-CN heterogeneous system is introduced to model the observed CN-rainfall variation by reducing the CN spatial variability into two classes. The behaviour of the CN-rainfall function produced by the simplified two-CN system is approached theoretically, it is analysed systematically, and it is found to be similar to the variation observed in natural watersheds. Synthetic data tests, natural watersheds examples, and detailed study of two natural experimental watersheds with known spatial heterogeneity characteristics were used to evaluate the method. The results indicate that the determination of CN values from rainfall runoff data using the proposed two-CN system approach provides reasonable accuracy and it over performs the previous methods based on the determination of a single asymptotic CN value. Although the suggested method increases the number of unknown parameters to three (instead of one, a clear physical reasoning for them is presented.

  19. Spatial heterogeneity study of vegetation coverage at Heihe River Basin

    Science.gov (United States)

    Wu, Lijuan; Zhong, Bo; Guo, Liyu; Zhao, Xiangwei

    2014-11-01

    Spatial heterogeneity of the animal-landscape system has three major components: heterogeneity of resource distributions in the physical environment, heterogeneity of plant tissue chemistry, heterogeneity of movement modes by the animal. Furthermore, all three different types of heterogeneity interact each other and can either reinforce or offset one another, thereby affecting system stability and dynamics. In previous studies, the study areas are investigated by field sampling, which costs a large amount of manpower. In addition, uncertain in sampling affects the quality of field data, which leads to unsatisfactory results during the entire study. In this study, remote sensing data is used to guide the sampling for research on heterogeneity of vegetation coverage to avoid errors caused by randomness of field sampling. Semi-variance and fractal dimension analysis are used to analyze the spatial heterogeneity of vegetation coverage at Heihe River Basin. The spherical model with nugget is used to fit the semivariogram of vegetation coverage. Based on the experiment above, it is found, (1)there is a strong correlation between vegetation coverage and distance of vegetation populations within the range of 0-28051.3188m at Heihe River Basin, but the correlation loses suddenly when the distance greater than 28051.3188m. (2)The degree of spatial heterogeneity of vegetation coverage at Heihe River Basin is medium. (3)Spatial distribution variability of vegetation occurs mainly on small scales. (4)The degree of spatial autocorrelation is 72.29% between 25% and 75%, which means that spatial correlation of vegetation coverage at Heihe River Basin is medium high.

  20. Contrast-enhanced 3T MR perfusion of musculoskeletal tumours. T1 value heterogeneity assessment and evaluation of the influence of T1 estimation methods on quantitative parameters

    Energy Technology Data Exchange (ETDEWEB)

    Gondim Teixeira, Pedro Augusto; Leplat, Christophe; Verbizier, Jacques de; Blum, Alain [Hopital Central, CHRU-Nancy, Service d' Imagerie Guilloz, Nancy (France); Chen, Bailiang; Beaumont, Marine [Universite de Lorraine, Laboratoire IADI, UMR S 947, Nancy (France); Badr, Sammy; Cotten, Anne [CHRU Lille Centre de Consultations et d' Imagerie de l' Appareil Locomoteur, Department of Radiology and Musculoskeletal Imaging, Lille (France)

    2017-12-15

    To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed. In 20 cases, normal muscle perfusion parameters were calculated using three different methods: signal based and gadolinium concentration based on fixed and variable T1 values. Tumour and normal muscle T1 values were significantly different (p = 0.0008). T1 value heterogeneity was higher in tumours than in normal muscle (variation of 19.8% versus 13%). The T1 estimation method had a considerable influence on the variability of perfusion parameters. Fixed T1 values yielded higher coefficients of variation than variable T1 values (mean 109.6 ± 41.8% and 58.3 ± 14.1% respectively). Area under the curve was the least variable parameter (36%). T1 values in musculoskeletal tumours are significantly different and more heterogeneous than normal muscle. Patient-specific T1 estimation is needed for direct inter-patient comparison of perfusion parameters. (orig.)

  1. Approximations for transport parameters and self-averaging properties for point-like injections in heterogeneous media

    International Nuclear Information System (INIS)

    Eberhard, Jens

    2004-01-01

    We focus on transport parameters in heterogeneous media with a flow modelled by an ensemble of periodic and Gaussian random fields. The parameters are determined by ensemble averages. We study to what extent these averages represent the behaviour in a single realization. We calculate the centre-of-mass velocity and the dispersion coefficient using approximations based on a perturbative expansion for the transport equation, and on the iterative solution of the Langevin equation. Compared with simulations, the perturbation theory reproduces the numerical results only poorly, whereas the iterative solution yields good results. Using these approximations, we investigate the self-averaging properties. The ensemble average of the velocity characterizes the behaviour of a realization for large times in both ensembles. The dispersion coefficient is not self-averaging in the ensemble of periodic fields. For the Gaussian ensemble the asymptotic dispersion coefficient is self-averaging. For finite times, however, the fluctuations are so large that the average does not represent the behaviour in a single realization

  2. SCS-CN parameter determination using rainfall-runoff data in heterogeneous watersheds. The two-CN system approach

    Science.gov (United States)

    Soulis, K. X.; Valiantzas, J. D.

    2011-10-01

    The Soil Conservation Service Curve Number (SCS-CN) approach is widely used as a simple method for predicting direct runoff volume for a given rainfall event. The CN values can be estimated by being selected from tables. However, it is more accurate to estimate the CN value from measured rainfall-runoff data (assumed available) in a watershed. Previous researchers indicated that the CN values calculated from measured rainfall-runoff data vary systematically with the rainfall depth. They suggested the determination of a single asymptotic CN value observed for very high rainfall depths to characterize the watersheds' runoff response. In this paper, the novel hypothesis that the observed correlation between the calculated CN value and the rainfall depth in a watershed reflects the effect of the inevitable presence of soil-cover complex spatial variability along watersheds is being tested. Based on this hypothesis, the simplified concept of a two-CN heterogeneous system is introduced to model the observed CN-rainfall variation by reducing the CN spatial variability into two classes. The behavior of the CN-rainfall function produced by the proposed two-CN system concept is approached theoretically, it is analyzed systematically, and it is found to be similar to the variation observed in natural watersheds. Synthetic data tests, natural watersheds examples, and detailed study of two natural experimental watersheds with known spatial heterogeneity characteristics were used to evaluate the method. The results indicate that the determination of CN values from rainfall runoff data using the proposed two-CN system approach provides reasonable accuracy and it over performs the previous original method based on the determination of a single asymptotic CN value. Although the suggested method increases the number of unknown parameters to three (instead of one), a clear physical reasoning for them is presented.

  3. Laboratory Studies of Atmospheric Heterogeneous Chemistry

    Science.gov (United States)

    Keyser, L. F.; Leu, M-T.

    1993-01-01

    In the laboratory, ice films formed by freezing from the liquid or more frequently by deposition from the vapor phase have been used to simulate stratospheric cloud surfaces for measurements of reaction and uptake rates. To obtain intrinsic surface reaction probabilities that can be used in atmospheric models, the area of the film surface that actually takes part in the reaction must be known. It is important to know not only the total surface area but also the film morphology in order to determine where and how the surface is situated and, thus, what fraction of it is available for reaction. Information on the structure of these ice films has been obtained by using several experimental methods. In the sections that follow, these methods will be discussed, then the results will be used to construct a working model of the ice films, and finally the model will be applied to an experimental study of HC1 uptake by H_2O ice.

  4. The Effect of Mechanical Anisotropy and Heterogeneity of Shear Strength Parameters of Soils on Drained Bearing Capacity of Shallow Foundations

    Directory of Open Access Journals (Sweden)

    R. Jamshidi Chenari

    2017-09-01

    Full Text Available Natural formation of soil deposits causes heterogeneity and anisotropy in their strength and stiffness properties. However, most soils in their natural states exhibit some anisotropy with respect to shear strength and heterogeneity with respect to the depth. In this paper, the standard Mohr- Coulomb constitutive law is generalized to anisotropic version in order to consider the effect of cohesion anisotropy of soil. Random field theory coupled with finite difference method was utilized in Monte Carlo simulations with considering the effect of auto-correlation and cross correlation between strength parameters of soil, in order to calculate the bearing capacity of shallow foundation in a strain controlled scheme. The results showed that the bearing capacity of shallow foundation decreases with increasing in variability of strength parameters and increases with increasing in anisotropy ratio.

  5. Contrast-enhanced 3T MR Perfusion of Musculoskeletal Tumours: T1 Value Heterogeneity Assessment and Evaluation of the Influence of T1 Estimation Methods on Quantitative Parameters.

    Science.gov (United States)

    Gondim Teixeira, Pedro Augusto; Leplat, Christophe; Chen, Bailiang; De Verbizier, Jacques; Beaumont, Marine; Badr, Sammy; Cotten, Anne; Blum, Alain

    2017-12-01

    To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed. In 20 cases, normal muscle perfusion parameters were calculated using three different methods: signal based and gadolinium concentration based on fixed and variable T1 values. Tumour and normal muscle T1 values were significantly different (p = 0.0008). T1 value heterogeneity was higher in tumours than in normal muscle (variation of 19.8% versus 13%). The T1 estimation method had a considerable influence on the variability of perfusion parameters. Fixed T1 values yielded higher coefficients of variation than variable T1 values (mean 109.6 ± 41.8% and 58.3 ± 14.1% respectively). Area under the curve was the least variable parameter (36%). T1 values in musculoskeletal tumours are significantly different and more heterogeneous than normal muscle. Patient-specific T1 estimation is needed for direct inter-patient comparison of perfusion parameters. • T1 value variation in musculoskeletal tumours is considerable. • T1 values in muscle and tumours are significantly different. • Patient-specific T1 estimation is needed for comparison of inter-patient perfusion parameters. • Technical variation is higher in permeability than semiquantitative perfusion parameters.

  6. Magnetic enzyme reactors for isolation and study of heterogeneous glycoproteins

    International Nuclear Information System (INIS)

    Korecka, Lucie; Jezova, Jana; Bilkova, Zuzana; Benes, Milan; Horak, Daniel; Hradcova, Olga; Slovakova, Marcela; Viovy, Jean-Louis

    2005-01-01

    The newly developed magnetic micro- and nanoparticles with defined hydrophobicity and porosity were used for the preparation of magnetic enzyme reactors. Magnetic particles with immobilized proteolytic enzymes trypsin, chymotrypsin and papain and with enzyme neuraminidase were used to study the structure of heterogeneous glycoproteins. Factors such as the type of carrier, immobilization procedure, operational and storage stability, and experimental conditions were optimized

  7. [Study on the heterogeneity of edema in severe preeclampsia].

    Science.gov (United States)

    Shi, Junmei; Yang, Zi; Chen, Lei

    2014-05-06

    The aim of this study was to analysis the clinical edema forms and explore the heterogeneity of edema in severe preeclampsia (PE) . From February 2002 to February 2009, Peking University Third Hospital admitted with severe preeclampsia 228 cases who were enrolled in this study. The form is divided into no edema (A-type), pure interstitial edema (B-type), a simple cavity gap edema (C-type) and mixed interstitial edema that coexist with lacunar edema (D-type). Analysis and comparison of various types of edema in patients with different clinical manifestations of prenatal care models, laboratory parameters, the incidence of gestational age, complications and obstetric and perinatal outcomes, and analyze the relationship between different types of edema and albumins and the peak value of proteinuria. Edema was seen in 86% (197/228) of all of cases. Compared the cases who have regular prenatal care with those who have irregular care, differences were statistically significant in edema type composition ratio (P 0.05); Compared early-onset PE and late-onset PE patients, differences were statistically significant in edema type composition ratio (P 0.05). Comparison between the various types of edema, differences were statistically significant in serum albumin levels and peak value of proteinuria and incidence of serious complications and the gestational week at PE onset and the incidence of treatment preterm labor (P edema(P edema were correlated with serum albumin levels (r = -0.19, P 0.05). The manifestations of edema were diverse in severe preeclampsia. The forms of edema were related to the PE onset of gestational age and serious complication involving in different organs.Strengthen prenatal care and early detection of edema may improve adverse obstetric outcomes.

  8. Program LATTICE for Calculation of Parameters of Targets with Heterogeneous (Lattice) Structure

    CERN Document Server

    Bznuni, S A; Soloviev, A G; Sosnin, A N

    2002-01-01

    Program LATTICE, with which help it is possible to describe lattice structure for the program complex CASCAD, is created in the C++ language. It is shown that for model-based electronuclear system on a basis of molten salt reactor with graphite moderator at transition from homogeneous structure to heterogeneous at preservation of a chemical compound there is a growth of k_{eff} by approximately 6 %.

  9. Comet Halley, parameter study I

    International Nuclear Information System (INIS)

    Huebner, W.F.; Fikani, M.M.

    1982-06-01

    To aid in defining a mission to comet P/Halley, its inner coma is simulated by a computer program that models time-dependent chemical reactions in a radially and isentropically expanding gas, taking into account attenuation of solar ultraviolet radiation in the subsolar direction. Column density predictions are based on intelligently selected combinations of poorly known values for nucleus parameters that include size, visual albedo, and infrared emissivity. Only one chemical composition and a minor modification of it are considered here; the dust-to-gas ratio in this model is zero. Although the somewhat optimistically volatile composition chosen here favors a smaller nucleus, a mean nuclear radius of only 0.5 km is unlikely. No significant increase of molecular column density is predicted by this model as a spacecraft approaches, once it is less than a few 10 4 km from the nucleus. Predictions are made for various heliocentric distances of interest for comet missions and for ground observations

  10. Numerical study of homogeneous–heterogeneous reactions in Sisko fluid flow past a stretching cylinder

    Directory of Open Access Journals (Sweden)

    Rabia Malik

    2018-03-01

    Full Text Available The motivation behind the present study is to focus on the effects of stagnation-point flow and heat transfer to the Sisko fluid past an impermeable stretching cylinder involving convective boundary conditions with homogeneous–heterogeneous reactions. Diffusion coefficients of species A and B are assumed to be of the same size. Also, it is assumed that heat released during chemical reaction is negligible. A system of governing ordinary differential equations is obtained by using suitable transformations which are then solved numerically by means of the shooting method combined with Runge-Kutta method. The obtained numerical results are then presented in graphical and tabular form and are discussed at length. The results obtained reveal that the concentration profile decreases with increasing homogeneous and heterogeneous reactions parameters. Keywords: Homogeneous–heterogeneous reactions, Non-linearly stretching cylinder, Stagnation-point flow, Convective boundary conditions, Sisko fluid

  11. Experimental and theoretical study of heterogeneous iron precipitation in silicon

    OpenAIRE

    Haarahiltunen, Antti; Väinölä, Hele; Anttila, O.; Yli-Koski, Marko

    2007-01-01

    Heterogeneous iron precipitation in silicon was studied experimentally by measuring the gettering efficiency of oxide precipitate density of 1×10exp10cm−3. The wafers were contaminated with varying iron concentrations, and the gettering efficiency was studied using isothermal annealing in the temperature range from 300 to 780°C. It was found that iron precipitation obeys the so called s-curve behavior: if iron precipitation occurs, nearly all iron is gettered. For example, after 30 min anneal...

  12. Estimation of mass transfer parameters in a Taylor-Couette-Poiseuille heterogeneous reactor

    Directory of Open Access Journals (Sweden)

    Resende M. M.

    2004-01-01

    Full Text Available A bench-scale, continuous vortex flow reactor (VFR, with a radius ratio, h, equal to 0.48 and an aspect ratio, G, equal to 11.19 was studied. This reactor may be used in the enzymatic hydrolysis of polypeptides obtained from sweet cheese whey with enzymes immobilized on agarose gel. Operational conditions were 2410 < Re q < 11793 and 30-min residence time for glycerol-water, 14% w/w, 27ºC (Re ax = 1.1 and for water, 38ºC (Re ax = 1.5. Residence time distributions (RTDs were obtained after pulse injections of different tracers (including dyed solid particles. Mass transfer coefficients of a lumped-parameter model of the reactor were estimated from these data. Model fitting to experimental data was accurate. Working conditions were selected so that transport properties of the fluids would be similar to the ones in the actual process at the final stages of whey hydrolysis.

  13. A Parameter Study of Localization

    Directory of Open Access Journals (Sweden)

    Sandor Stephen Mester

    1996-01-01

    Full Text Available Extensive work has been done on the vibration characteristics of perfectly periodic structures. Disorder in the periodic pattern has been found to lead to localization in one-dimensional periodic structures. It is important to understand localization because it causes energy to be concentrated near the disorder and may cause an overestimation of structural damping. A numerical study is conducted to obtain a better understanding of localization. It is found that any mode, even the first, can localize due to the presence of small imperfections.

  14. Studies of spatial decoupling in heterogeneous LMFBR critical assemblies

    International Nuclear Information System (INIS)

    Brumbach, S.B.; Goin, R.W.; Carpenter, S.G.

    1984-01-01

    Recent measurements at the Zero Power Plutonium Reactor have studied the spatial decoupling in large, heterogeneous assemblies. These assemblies exhibited a significantly greater degree of decoupling than previous homogeneous assemblies of similar size. The flux distributions in these heterogeneous assemblies were very sensitive reactivity perturbations, and perturbed flux distributions were achieved relatively slowly. Decoupling was investigated using rod-drop, boron-oscillator and noise-coherence techniques which emphasized different times following the perturbations. Reactivity changes could be measured by analyzing the power history from a single detector using inverse kinetics methods with the assumption of an instantaneous efficiency change for the detector. For assemblies more decoupled than ZPPR-13, the instantaneous efficiency change assumption begins to be invalid

  15. Strategic Voting in Heterogeneous Electorates: An Experimental Study

    Directory of Open Access Journals (Sweden)

    Marcelo Tyszler

    2013-11-01

    Full Text Available We study strategic voting in a setting where voters choose from three options and Condorcet cycles may occur. We introduce in the electorate heterogeneity in preference intensity by allowing voters to differ in the extent to which they value the three options. Three information conditions are tested: uninformed, in which voters know only their own preference ordering and the own benefits from each option; aggregate information, in which in addition they know the aggregate realized distribution of the preference orderings and full information, in which they also know how the relative importance attributed to the options are distributed within the electorate. As a general result, heterogeneity seems to decrease the level of strategic voting in our experiment compared to the homogenous preference case that we study in a companion paper. Both theoretically and empirically (with data collected in a laboratory experiment, the main comparative static results obtained for the homogenous case carry over to the present setting with preference heterogeneity. Moreover, information about the realized aggregate distribution of preferences seems to be the element that best explains observed differences in voting behavior. Additional information about the realized distribution of preference intensity does not yield significant further changes.

  16. The dispersal of contaminants in heterogeneous aquifers: a review of methods of estimating scale dependent parameters

    International Nuclear Information System (INIS)

    Farmer, C.L.

    1986-02-01

    The design and assessment of underground waste disposal options requires modelling the dispersal of contaminants within aquifers. The logical structure of the development and application of disposal models is discussed. In particular we examine the validity and interpretation of the gradient diffusion model. The effective dispersion parameters in such a model seem to depend upon the scale on which they are measured. This phenomenon is analysed and methods for modelling scale dependent parameters are reviewed. Specific recommendations regarding the modelling of contaminant dispersal are provided. (author)

  17. Optimum parameters in a model for tumour control probability, including interpatient heterogeneity: evaluation of the log-normal distribution

    International Nuclear Information System (INIS)

    Keall, P J; Webb, S

    2007-01-01

    The heterogeneity of human tumour radiation response is well known. Researchers have used the normal distribution to describe interpatient tumour radiosensitivity. However, many natural phenomena show a log-normal distribution. Log-normal distributions are common when mean values are low, variances are large and values cannot be negative. These conditions apply to radiosensitivity. The aim of this work was to evaluate the log-normal distribution to predict clinical tumour control probability (TCP) data and to compare the results with the homogeneous (δ-function with single α-value) and normal distributions. The clinically derived TCP data for four tumour types-melanoma, breast, squamous cell carcinoma and nodes-were used to fit the TCP models. Three forms of interpatient tumour radiosensitivity were considered: the log-normal, normal and δ-function. The free parameters in the models were the radiosensitivity mean, standard deviation and clonogenic cell density. The evaluation metric was the deviance of the maximum likelihood estimation of the fit of the TCP calculated using the predicted parameters to the clinical data. We conclude that (1) the log-normal and normal distributions of interpatient tumour radiosensitivity heterogeneity more closely describe clinical TCP data than a single radiosensitivity value and (2) the log-normal distribution has some theoretical and practical advantages over the normal distribution. Further work is needed to test these models on higher quality clinical outcome datasets

  18. Study of heterogeneous nuclear reactor lattice properties in multizone systems

    International Nuclear Information System (INIS)

    Raisic, N.M.

    1964-12-01

    Described analysis of substitution experiments and its comparison with the classic procedures showed that it could be successfully applied for processing the experimental results. This method shows some advantages and some deficiencies compared to classic methods. Precision of the method is considered sufficient for design of nuclear facilities. Routine standards used in design of nuclear facilities demand following precision of nuclear parameters: about 5% during feasibility study and design of heavy water facility with natural uranium; 2 - 3% in the phase of parameters optimisation and preparing the main project; 1% during optimization of operation. Accuracy of core parameters obtained by analysis of substitution experiments show that they could be successfully used in the phase of reactor parameters optimisation. It is possible to increase the precision of critical parameters and thus apply the proposed method for analysis of reactor parameters needed in the phase of operation optimization

  19. Semiconductor Sensors for Studying the Heterogeneous Destruction of Ozone at Low Concentrations

    Science.gov (United States)

    Obvintseva, L. A.; Sharova, T. B.; Avetisov, A. K.; Sukhareva, I. P.

    2018-06-01

    Prospects for the use of semiconductor resistive sensors in studies of the heterogeneous destruction of ozone at low concentrations (5-400 μg/m3) were shown. The influence of various factors (sensor temperature, gas flow rate, ozone concentration) on the results of ozone concentration measurements with sensors of various types was studied. Methods for forming a sensitive layer of In2O3(3% Fe2O3) sensors with specified parameters of calibration curves were proposed. The optimum conditions for the operation of sensors in a flow mode were formulated. The results of the study of heterogeneous destruction of ozone on microfiber polymer and natural disperse (sand, coals) materials obtained by the developed method were presented.

  20. Capturing heterogeneity in gene expression studies by surrogate variable analysis.

    Directory of Open Access Journals (Sweden)

    Jeffrey T Leek

    2007-09-01

    Full Text Available It has unambiguously been shown that genetic, environmental, demographic, and technical factors may have substantial effects on gene expression levels. In addition to the measured variable(s of interest, there will tend to be sources of signal due to factors that are unknown, unmeasured, or too complicated to capture through simple models. We show that failing to incorporate these sources of heterogeneity into an analysis can have widespread and detrimental effects on the study. Not only can this reduce power or induce unwanted dependence across genes, but it can also introduce sources of spurious signal to many genes. This phenomenon is true even for well-designed, randomized studies. We introduce "surrogate variable analysis" (SVA to overcome the problems caused by heterogeneity in expression studies. SVA can be applied in conjunction with standard analysis techniques to accurately capture the relationship between expression and any modeled variables of interest. We apply SVA to disease class, time course, and genetics of gene expression studies. We show that SVA increases the biological accuracy and reproducibility of analyses in genome-wide expression studies.

  1. Synopses/physical significance of complex-valued catalyst parameters in heterogeneous catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Hesse, D

    1979-08-01

    An independent parameter was used to describe the local values of the interdependent thermodynamic variables of the coupled effects of transfer, sorption, and surface reaction at steady state in a packed bed of porous catalyst. A system reduction yielded a generalized concept of the pore effectiveness factor, H, which was unity or a real or imaginary complex number when the coupled diffusion and reaction processes do not affect, inhibit, or enhance conversion, respectively. These concepts are illustrated by ethylene hydrogenation on platinum, a process in which ethylene adsorbs much more strongly than hydrogen, but diffuses more slowly; as the rate is proportional to the product of hydrogen and ethylene surface coverage and the more strongly adsorbed ethylene occupies the majority of the available sites, a decrease in gas-phase ethylene concentration would increase the conversion rate. The reaction rate also increases with decreasing distance from the catalyst particle core.

  2. Qualitative Parameters of Practice during University Studies

    Science.gov (United States)

    Stasiunaitiene, Egle; Norkute, Odeta

    2011-01-01

    In this article, relevance of practice during university studies is highlighted, as well as the main stages of its organisation, qualitative parameters, as well as criteria and indicators that validate them are defined. Discussion on the idea that taking into consideration qualitative parameters of organising practice as a component of studies…

  3. Heterogeneity within compulsive buyers: a Q-sort study.

    Science.gov (United States)

    Thornhill, Kate; Kellett, Stephen; Davies, Jason

    2012-06-01

    This study investigated how compulsive buyers make sense of their excessive shopping behaviour to explore possible sources of heterogeneity between compulsive buyers. Twenty female participants met 'caseness' for compulsive buying (CB) on the CB Scale (CBS), prior to completing a Q-sort specifically related to their experiences of shopping. Participants provided details of occupation, income, and debt levels and completed two psychometric scales: the Hospital Anxiety and Depression Scale (HADS) and Yale Brown Obsessive Compulsive Scale-Shopping Version (YBOCS-SV). Principle component analysis (PCA) identified two groups within the compulsive buyers (labelled positive reinforcement and emotional distress) that explained 44% of the study variance. Ten women defined the positive reinforcement factor and tended to identify with pleasurable aspects of buying. Six women characterized the emotional distress factor and endorsed varied financial, emotional, and interpersonal difficulties associated with their CB. The emotional distress group carried significantly greater current debt levels and had significantly more severe CB. The study illustrates that compulsive buyers can relate to their 'symptoms' in dissimilar ways. The clinical implications of such heterogeneity are discussed, methodological shortcomings identified, and areas for future research indicated. ©2011 The British Psychological Society.

  4. Source parameter inversion for wave energy focusing to a target inclusion embedded in a three-dimensional heterogeneous halfspace

    KAUST Repository

    Karve, Pranav M.

    2016-12-28

    We discuss a methodology for computing the optimal spatio-temporal characteristics of surface wave sources necessary for delivering wave energy to a targeted subsurface formation. The wave stimulation is applied to the target formation to enhance the mobility of particles trapped in its pore space. We formulate the associated wave propagation problem for three-dimensional, heterogeneous, semi-infinite, elastic media. We use hybrid perfectly matched layers at the truncation boundaries of the computational domain to mimic the semi-infiniteness of the physical domain of interest. To recover the source parameters, we define an inverse source problem using the mathematical framework of constrained optimization and resolve it by employing a reduced-space approach. We report the results of our numerical experiments attesting to the methodology\\'s ability to specify the spatio-temporal description of sources that maximize wave energy delivery. Copyright © 2016 John Wiley & Sons, Ltd.

  5. Specification of electron beam quality from ionization distribution in central axis and a study about heterogenity effects in these distributions

    International Nuclear Information System (INIS)

    Fernandes, R.F.

    1984-01-01

    Some parameters on physical and terapeutic properties of the electron beams generated by ''nevratron XII'' accelerator of the Hospital of Medicine in Ribeirao Preto - USP, Brasil are evaluated. The effects from heterogenities into an irradiated mean, called ''phantom'' or simulator are studied. (M.J.C.) [pt

  6. Field study of macrodispersion in a heterogeneous aquifer. 2

    International Nuclear Information System (INIS)

    Boggs, J.M.; Rehfeldt, K.R.

    1990-01-01

    Observations of the spatial variability of the hydraulic conductivity field at the site of a large-scale natural gradient tracer experiment located at Columbus Air Force Base in Mississippi are presented. Direct measurements of hydraulic conductivity of the heterogeneous alluvial aquifer at the site were made using a variety of methods including aquifer tests, borehole flowmeter logging, double-packer tests, slug tests, and a newly developed laboratory permeameter to test undisturbed soil cores. The borehole flowmeter method was shown to be the most effective method for measuring conductivity variability. Estimates of the log hydraulic conductivity variance (σ 2 lnL ) and the horizontal and vertical correlation sales, (λ h and λ v ) of 4.5, 12 m, and 1.5 m, respectively, were calculated assuming second order stationarity of the conductivity field. Large-scale spatial variations in the mean groundwater velocity indicated by the natural gradient tracer experiment, which were shown to be a direct result of contrasts in the mean hydraulic conductivity along the plume pathway, strongly suggested the presence of a conductivity trend. The measured hydraulic conductivity data were subsequently detrended using least-squares regression to remove three-dimensional polynomials. The third-order polynomial was judged the best representation of the conductivity drift based on its overall compatibility with the groundwater flow field inferred from the tracer plume observations. Significantly lower estimates for σ 2 lnK , λ h , and λ v of 2.8, 5.3 m, and 0.7 m, respectively, were obtained from the third-order log conductivity residuals. The experience with the borehole flowmeter technique shows the feasibility of observing the statistical parameters of the hydraulic conductivity variability required for stochastic models of macrodispersion. (Author) (20 refs., 3 figs., 10 tabs.)

  7. Cloud-Based Parameter-Driven Statistical Services and Resource Allocation in a Heterogeneous Platform on Enterprise Environment

    Directory of Open Access Journals (Sweden)

    Sungju Lee

    2016-09-01

    Full Text Available A fundamental key for enterprise users is a cloud-based parameter-driven statistical service and it has become a substantial impact on companies worldwide. In this paper, we demonstrate the statistical analysis for some certain criteria that are related to data and applied to the cloud server for a comparison of results. In addition, we present a statistical analysis and cloud-based resource allocation method for a heterogeneous platform environment by performing a data and information analysis with consideration of the application workload and the server capacity, and subsequently propose a service prediction model using a polynomial regression model. In particular, our aim is to provide stable service in a given large-scale enterprise cloud computing environment. The virtual machines (VMs for cloud-based services are assigned to each server with a special methodology to satisfy the uniform utilization distribution model. It is also implemented between users and the platform, which is a main idea of our cloud computing system. Based on the experimental results, we confirm that our prediction model can provide sufficient resources for statistical services to large-scale users while satisfying the uniform utilization distribution.

  8. Feasibility study on heterogeneous method in criticality calculations

    International Nuclear Information System (INIS)

    Prati, A.

    1977-01-01

    The criticality of finite heterogeneous assemblies is analysed by the heterogeneous methods employing the Eigen-function analysis. The moderation is treated by the Fermi age theory. The system is analysed in two dimensional rectangular coordinates. The criticality and the fluxes are determined for systems with small and large number of fuel rods. The convergence and the residual error in the modal analysis are discussed. (author)

  9. Sensibility and time heterogeneity of Biome-BGC model parameters%Biome-BGC模型参数的敏感性和时间异质性

    Institute of Scientific and Technical Information of China (English)

    刘秋雨; 张廷龙; 孙睿; 王博闻; 叶欣欣; 李一哲

    2017-01-01

    生态过程模型为研究陆表生态系统水、碳、氮等物质的循环提供了一种有效的手段.模型与数据同化结合可建立模拟与观测之间的桥梁,同时提高模型与观测两种方法揭示地表真实状况的有效性.但模型参数的特性,将直接影响到模型模拟及数据同化的精度.传统观念认为,生态过程模型参数在相同植被类型条件下是固定不变的,但近期研究已开始关注其时空异质性.本文以Biome-BGC模型为例,利用美国哈佛森林Environmental Monitoring Site (EMS)通量观测站的相关数据,对哈佛森林地区水、碳通量进行模拟.首先对模型参数进行敏感性分析;然后应用模拟退火算法,构造目标函数,使待优化的敏感参数在合理阈值范围内不断变动反复迭代,获取逐月的最优参数值;通过引入变异系数,对敏感参数的时间异质性进行分析.结果表明:生态过程模型参数最优值并非常量,而会随时间表现出异质性,而且各参数时间异质性大小差异显著.文中对Biome-BGC模型的敏感参数按时间异质性大小划分了相应的等级.研究结果有助于加深对生态过程模型参数特性的认识,为参数的合理取值及动态优化提供思路与依据,有助于进一步提高模型模拟和数据同化的精度与效率.%Ecological process model provides an effective way for studying water,carbon and nitrogen cycles of terrestrial ecosystem.The combination of the model and data assimilation could build a link between observation and simulation,which improves the effectiveness of model and observation methods to reveal the real state of land surface,but the accuracy of simulation and assimilation is directly affected by model parameters.Parameters are constants in traditional opinion;however,some current studies have focused on the time-space heterogeneity of parameters.In this paper,we used Harvard Forest Environmental Monitoring Site (EMS) data to simulate

  10. Energy flux simulation in heterogeneous cropland - a two year study

    Science.gov (United States)

    Klein, Christian; Thieme, Christoph; Biernath, Christian; Heinlein, Florian; Priesack, Eckart

    2016-04-01

    Recent studies show that uncertainties in regional and global climate and weather simulations are partly due to inadequate descriptions of the energy flux exchanges between the land surface and the atmosphere [Stainforth et al. 2005]. One major shortcoming is the limitation of the grid-cell resolution, which is recommended to be about at least 3x3 km² in most models due to limitations in the model physics. To represent each individual grid cell most models select one dominant soil type and one dominant land use type. This resolution, however, is often too coarse in regions where the spatial heterogeneity of soil and land use types are high, e.g. in Central Europe. The relevance of vegetation (e.g. crops), ground cover, and soil properties to the moisture and energy exchanges between the land surface and the atmosphere is well known [McPherson 2007], but the impact of vegetation growth dynamics on energy fluxes is only partly understood [Gayler et al. 2014]. An elegant method to avoid the shortcoming of grid cell resolution is the so called mosaic approach. This approach is part of the recently developed ecosystem model framework Expert-N [Biernath et al. 2013] . The aim of this study was to analyze the impact of the characteristics of five managed field plots, planted with winter wheat, potato and maize on the near surface soil moistures and on the near surface energy flux exchanges of the soil-plant-atmosphere interface. The simulated energy fluxes were compared with eddy flux tower measurements between the respective fields at the research farm Scheyern, North-West of Munich, Germany. To perform these simulations, we coupled the ecosystem model Expert-N to an analytical footprint model [Mauder & Foken 2011] . The coupled model system has the ability to calculate the mixing ratio of the surface energy fluxes at a given point within one grid cell (in this case at the flux tower between the two fields). The approach accounts for the temporarily and spatially

  11. High Content Analysis of Compositional Heterogeneities to Study GPCR Oligomerization

    DEFF Research Database (Denmark)

    Walsh, Samuel McEwen

    In this thesis I demonstrate how the natural compositional heterogeneities of synthetic and living cell model systems can be used to quantitate the mechanics of G-protein coupled receptor (GPCR) oligomerization with Förster resonance energy transfer (FRET). The thesis is structured around three a...

  12. Field study of macrodispersion in a heterogeneous aquifer. 3

    International Nuclear Information System (INIS)

    Beard, L.M.; Stauffer, T.B.; MacIntyre, W.G.

    1990-01-01

    The Tennessee Valley Authority is conducting a second large-scale groundwater research study. In this experiment, dissolved tracers are being injected into a shallow alluvium aquifer. This study will support groundwater protection by making possible more effective design of waste storage facilities, improving monitoring systems, and designing better mitigation programs. The objectives of this study are to better understand the dominant physical and chemical factors affecting contaminant movement in groundwater. A data set will be provided for evaluating transport models and for assessing the reliability of laboratory measure parameters to predict transport. Tritiated water was used as the conservative, nonreactive tracer to overcome problems experienced with the use of bromide in the first experiment. Four non-conservative tracers (naphthalene, carbon 14-labeled para-xylene, benzene, and ortho-dichlorobenzene) were also injected. This paper describes initial laboratory tests and the design and implementation of the second natural gradient injection experiment. (Author) (13 refs., 5 figs., 4 tabs.)

  13. Electrical resistivity sounding to study water content distribution in heterogeneous soils

    Science.gov (United States)

    Electrical resistivity (ER) sounding is increasingly being used as non-invasive technique to reveal and map soil heterogeneity. The objective of this work was to assess ER sounding applicability to study soil water distribution in spatially heterogeneous soils. The 30x30-m study plot was located at ...

  14. Topographical heterogeneity in transparent PVA hydrogels studied by AFM

    Energy Technology Data Exchange (ETDEWEB)

    Pramanick, Ashit Kumar; Gupta, Siddhi, E-mail: siddhigupta@nmlindia.org; Mishra, Trilochan; Sinha, Arvind

    2012-02-01

    Physically crosslinked poly (vinyl alcohol) (PVA) hydrogels have a wide range of biomedical applications. Transparent and stable PVA hydrogels synthesized by freeze-thawing method are potential candidates to be used as tissue engineering scaffolds provided they exhibit suitable topographical roughness and surface energy. The effect of processing parameters i.e., polymer concentration and number of freeze-thaw cycles on the resulting topography of the freeze-thawed transparent hydrogels has been studied and quantified using non-contact mode of an atomic force microscope (AFM) and image analysis. Simultaneously captured phase contrast images have revealed significant information about morphological changes in the topographical features and crystallinity of the hydrogels. Topographical roughness was found to decrease as a function of number of freeze-thaw cycles.

  15. Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer.

    Science.gov (United States)

    Tixier, Florent; Groves, Ashley M; Goh, Vicky; Hatt, Mathieu; Ingrand, Pierre; Le Rest, Catherine Cheze; Visvikis, Dimitris

    2014-01-01

    Thirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis. Blood flow visualization provided by DCE-CT images was significantly correlated with 18F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-valueheterogeneity of 18F-FDG PET accumulation reflects to some extent tracer distribution and consequently indicates that 18F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization.

  16. Use of a multigrid technique to study effects of limited sampling of heterogeneity on transport prediction

    International Nuclear Information System (INIS)

    Cole, C.R.; Foote, H.P.

    1987-02-01

    Reliable ground water transport prediction requires accurate spatial and temporal characterization of a hydrogeologic system. However, cost constraints and the desire to maintain site integrity by minimizing drilling can restrict the amount of spatial sampling that can be obtained to resolve the flow parameter variability associated with heterogeneities. This study quantifies the errors in subsurface transport predictions resulting from incomplete characterization of hydraulic conductivity heterogeneity. A multigrid technique was used to simulate two-dimensional flow velocity fields with high resolution. To obtain these velocity fields, the finite difference code MGRID, which implements a multigrid solution technique, was applied to compute stream functions on a 256-by-256 grid for a variety of hypothetical systems having detailed distributions of hydraulic conductivity. Spatial variability in hydraulic conductivity distributions was characterized by the components in the spectrum of spatial frequencies. A low-pass spatial filtering technique was applied to the base case hydraulic conductivity distribution to produce a data set with lower spatial frequency content. Arrival time curves were then calculated for filtered hydraulic conductivity distribution and compared to base case results to judge the relative importance of the higher spatial frequency components. Results indicate a progression from multimode to single-mode arrival time curves as the number and extent of distinct flow pathways are reduced by low-pass filtering. This relationship between transport predictions and spatial frequencies was used to judge the consequences of sampling the hydraulic conductivity with reduced spatial resolution. 22 refs., 17 figs

  17. Heterogeneity of acute myeloblastic leukemia without maturation: an ultrastructural study.

    Science.gov (United States)

    Hamamoto, K; Date, M; Taniguchi, H; Nagano, T; Kishimoto, Y; Kimura, T; Fukuhara, S

    1995-01-01

    We demonstrated by ultrastructural examination that the leukemic blasts of 13 patients with acute myeloblastic leukemia (AML) without maturation (M1 in the French-American-British classification) showed heterogeneous features. In 7 patients, the leukemic blasts had a high level of light microscopic myeloperoxidase positivity (> 50%). Ultrastructurally, the cells were myeloblast-promyelocytes with 100% myeloperoxidase positivity, and these 7 patients appeared to have typical AML. In contrast, the remaining 6 patients had leukemic blasts with a low myeloperoxidase positivity (undifferentiated blasts. The former group had a better prognosis than the latter, indicating that ultrastructural analysis of M1 leukemia may help predict the response to therapy.

  18. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor

    International Nuclear Information System (INIS)

    Di Salvo, J.

    2002-01-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  19. Evaluation of optical remote sensing parameters to improve modeling of gross primary productivity in a heterogeneous agricultural area

    Science.gov (United States)

    Schickling, A.; Damm, A.; Schween, J.; Rascher, U.; Crewell, S.; Wahner, A.

    2011-12-01

    Terrestrial photosynthesis greatly determines plant mediated exchange processes in the vegetation atmosphere system and substantially influences patterns in atmospheric carbon dioxide (CO2) concentrations and water vapor. Therefore, an accurate quantification of photosynthetic CO2 uptake, commonly referred to as gross primary productivity (GPP), is a key parameter to distinguish those atmospheric patterns on various spatio-temporal scales. Remote sensing (RS) offers the unique possibility to determine GPP at different spatial scales ranging from the local to the global scale. Attempts to estimate GPP from RS data focus on the light use efficiency (LUE) concept of Monteith which relates GPP to the absorbed photosynthetically active radiation and the efficiency of plant canopies to utilize the absorbed radiation for photosynthesis. To reliably predict GPP on different spatio-temporal scales LUE has to be linked to optical RS parameters which detect changes in photosynthetic efficiency due to environmental conditions. In this study we evaluated two optical RS parameters, namely the sun-induced fluorescence (Fs) and the photochemical reflectance index (PRI), for their potential to serve as a proxy for LUE. The parameters were derived from two ASD FieldSpec spectrometers which were operated in parallel. During several days one instrument was installed on the ground above the vegetation canopy of either a winter wheat or a sugar beet field. The second instrument was operated from a small research aircraft continuously crossing the observation sites at low altitude (sugar beet fields during the day. Results of this spatio-temporal investigation revealed a significant variability of GPP between different winter wheat fields compared to the within-field variability. In addition to the significant between-field variability of sugar beet the results also showed an increase of the within-field variability in the afternoon. Moreover, for the first time it could be shown that

  20. Study of heterogeneous and reconfigurable architectures in the communication domain

    Science.gov (United States)

    Feldkaemper, H. T.; Blume, H.; Noll, T. G.

    2003-05-01

    One of the most challenging design issues for next generations of (mobile) communication systems is fulfilling the computational demands while finding an appropriate trade-off between flexibility and implementation aspects, especially power consumption. Flexibility of modern architectures is desirable, e.g. concerning adaptation to new standards and reduction of time-to-market of a new product. Typical target architectures for future communication systems include embedded FPGAs, dedicated macros as well as programmable digital signal and control oriented processor cores as each of these has its specific advantages. These will be integrated as a System-on-Chip (SoC). For such a heterogeneous architecture a design space exploration and an appropriate partitioning plays a crucial role. On the exemplary vehicle of a Viterbi decoder as frequently used in communication systems we show which costs in terms of ATE complexity arise implementing typical components on different types of architecture blocks. A factor of about seven orders of magnitude spans between a physically optimised implementation and an implementation on a programmable DSP kernel. An implementation on an embedded FPGA kernel is in between these two representing an attractive compromise with high flexibility and low power consumption. Extending this comparison to further components, it is shown quantitatively that the cost ratio between different implementation alternatives is closely related to the operation to be performed. This information is essential for the appropriate partitioning of heterogeneous systems.

  1. Study of heterogeneous and reconfigurable architectures in the communication domain

    Directory of Open Access Journals (Sweden)

    H. T. Feldkaemper

    2003-01-01

    Full Text Available One of the most challenging design issues for next generations of (mobile communication systems is fulfilling the computational demands while finding an appropriate trade-off between flexibility and implementation aspects, especially power consumption. Flexibility of modern architectures is desirable, e.g. concerning adaptation to new standards and reduction of time-to-market of a new product. Typical target architectures for future communication systems include embedded FPGAs, dedicated macros as well as programmable digital signal and control oriented processor cores as each of these has its specific advantages. These will be integrated as a System-on-Chip (SoC. For such a heterogeneous architecture a design space exploration and an appropriate partitioning plays a crucial role. On the exemplary vehicle of a Viterbi decoder as frequently used in communication systems we show which costs in terms of ATE complexity arise implementing typical components on different types of architecture blocks. A factor of about seven orders of magnitude spans between a physically optimised implementation and an implementation on a programmable DSP kernel. An implementation on an embedded FPGA kernel is in between these two representing an attractive compromise with high flexibility and low power consumption. Extending this comparison to further components, it is shown quantitatively that the cost ratio between different implementation alternatives is closely related to the operation to be performed. This information is essential for the appropriate partitioning of heterogeneous systems.

  2. Study of electroweak parameters at LEP

    International Nuclear Information System (INIS)

    Blum, W.

    1991-10-01

    The measurement of the line shape and asymmetry parameters of the Z 0 in its leptonic and hadronic decays are reviewed. Progress is reported about a considerable increase in measurement accuracy. Several tests of the Standard Model confirm it to better than one per cent. New values for the effective mixing parameter are derived from the line shape parameters averaged over the four LEP experiments. The corresponding limits on the top mass are presented. (orig.)

  3. The impact of individual-level heterogeneity on estimated infectious disease burden: a simulation study.

    Science.gov (United States)

    McDonald, Scott A; Devleesschauwer, Brecht; Wallinga, Jacco

    2016-12-08

    Disease burden is not evenly distributed within a population; this uneven distribution can be due to individual heterogeneity in progression rates between disease stages. Composite measures of disease burden that are based on disease progression models, such as the disability-adjusted life year (DALY), are widely used to quantify the current and future burden of infectious diseases. Our goal was to investigate to what extent ignoring the presence of heterogeneity could bias DALY computation. Simulations using individual-based models for hypothetical infectious diseases with short and long natural histories were run assuming either "population-averaged" progression probabilities between disease stages, or progression probabilities that were influenced by an a priori defined individual-level frailty (i.e., heterogeneity in disease risk) distribution, and DALYs were calculated. Under the assumption of heterogeneity in transition rates and increasing frailty with age, the short natural history disease model predicted 14% fewer DALYs compared with the homogenous population assumption. Simulations of a long natural history disease indicated that assuming homogeneity in transition rates when heterogeneity was present could overestimate total DALYs, in the present case by 4% (95% quantile interval: 1-8%). The consequences of ignoring population heterogeneity should be considered when defining transition parameters for natural history models and when interpreting the resulting disease burden estimates.

  4. A method for comparing intra-tumoural radioactivity uptake heterogeneity in preclinical positron emission tomography studies

    International Nuclear Information System (INIS)

    Grafström, Jonas; Ahlzén, Hanna-Stina; Stone-Elander, Sharon

    2015-01-01

    Non-uniformity influences the interpretation of nuclear medicine based images and consequently their use in treatment planning and monitoring. However, no standardised method for evaluating and ranking heterogeneity exists. Here, we have developed a general algorithm that provides a ranking and a visualisation of the heterogeneity in small animal positron emission tomography (PET) images. The code of the algorithm was written using the Matrix Laboratory software (MATLAB). Parameters known to influence the heterogeneity (distances between deviating peaks, gradients and size compensations) were incorporated into the algorithm. All data matrices were mathematically constructed in the same format with the aim of maintaining overview and control. Histograms visualising the spread and frequency of contributions to the heterogeneity were also generated. The construction of the algorithm was tested using mathematically generated matrices and by varying post-processing parameters. It was subsequently applied in comparisons of radiotracer uptake in preclinical images in human head and neck carcinoma and endothelial and ovarian carcinoma xenografts. Using the developed algorithm, entire tissue volumes could be assessed and gradients could be handled in an indirect manner. Similar-sized volumes could be compared without modifying the algorithm. Analyses of the distribution of different tracers gave results that were generally in accordance with single plane preclinical images, indicating that it could appropriately handle comparisons of targeting vs. non-targeting tracers and also for different target levels. Altering the reconstruction algorithm, pixel size, tumour ROI volumes and lower cut-off limits affected the calculated heterogeneity factors in expected directions but did not reverse conclusions about which tumour was more or less heterogeneous. The algorithm constructed is an objective and potentially user-friendly tool for one-to-one comparisons of heterogeneity in

  5. A method for comparing intra-tumoural radioactivity uptake heterogeneity in preclinical positron emission tomography studies

    Energy Technology Data Exchange (ETDEWEB)

    Grafström, Jonas; Ahlzén, Hanna-Stina [Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm (Sweden); Stone-Elander, Sharon [Department of Clinical Neuroscience, Karolinska Institutet, SE-17176 Stockholm (Sweden); PET Radiochemistry, Neuroradiology Department, Karolinska University Hospital, SE-17176 Stockholm (Sweden)

    2015-09-08

    Non-uniformity influences the interpretation of nuclear medicine based images and consequently their use in treatment planning and monitoring. However, no standardised method for evaluating and ranking heterogeneity exists. Here, we have developed a general algorithm that provides a ranking and a visualisation of the heterogeneity in small animal positron emission tomography (PET) images. The code of the algorithm was written using the Matrix Laboratory software (MATLAB). Parameters known to influence the heterogeneity (distances between deviating peaks, gradients and size compensations) were incorporated into the algorithm. All data matrices were mathematically constructed in the same format with the aim of maintaining overview and control. Histograms visualising the spread and frequency of contributions to the heterogeneity were also generated. The construction of the algorithm was tested using mathematically generated matrices and by varying post-processing parameters. It was subsequently applied in comparisons of radiotracer uptake in preclinical images in human head and neck carcinoma and endothelial and ovarian carcinoma xenografts. Using the developed algorithm, entire tissue volumes could be assessed and gradients could be handled in an indirect manner. Similar-sized volumes could be compared without modifying the algorithm. Analyses of the distribution of different tracers gave results that were generally in accordance with single plane preclinical images, indicating that it could appropriately handle comparisons of targeting vs. non-targeting tracers and also for different target levels. Altering the reconstruction algorithm, pixel size, tumour ROI volumes and lower cut-off limits affected the calculated heterogeneity factors in expected directions but did not reverse conclusions about which tumour was more or less heterogeneous. The algorithm constructed is an objective and potentially user-friendly tool for one-to-one comparisons of heterogeneity in

  6. Sources of heterogeneity in studies of the BMI-mortality association.

    Science.gov (United States)

    Peter, Raphael Simon; Nagel, Gabriele

    2017-06-01

    To date, the amount of heterogeneity among studies of the body mass index-mortality association attributable to differences in the age distribution and length of follow-up has not been quantified. Therefore, we wanted to quantify the amount of heterogeneity attributable to age and follow-up in results of studies on the body mass index-mortality relation. We used optima of the body mass index mortality association reported for 30 populations and performed meta-regression to estimate the amount of heterogeneity attributable to sex, ethnicity, mean age at baseline, percentage smokers, and length of follow-up. Ethnicity as single factor accounted for 36% (95% CI, 11-56%) of heterogeneity. Mean age and length of follow-up had an interactive effect and together accounted for 56% (95% CI, 24-74%) of the remaining heterogeneity. Sex did not significantly contribute to the heterogeneity, after controlling for ethnicity, age, and length of follow-up. A considerable amount of heterogeneity in studies of the body mass index-mortality association is attributable to ethnicity, age, and length of follow-up. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  7. Field study of macrodispersion in a heterogeneous aquifer. I

    International Nuclear Information System (INIS)

    Boggs, J.M.; Young, S.C.; Waldrop, W.R.; Gelhar, L.W.; Adams, E.E.; Rehfeldt, K.R.

    1990-01-01

    A large-scale natural gradient tracer experiment has been conducted at a field site located at Columbus Air Force Base in northeastern Mississippi. The alluvial aquifer at the test site is composed of lenticular deposits of sand, gravel, silt and clay, and is quite heterogeneous with respect to its hydraulic properties. Ten cubic meters of a solution containing bromide and three organic tracers (pentafluorobenzoic acid, o-trifluoromethylbenzoic acid, and 2,6-difluorobenzoic acid) were injected into the aquifer at a uniform rate over a period of two days. The tracer plume was subsequently monitored in three dimensions over a 20-month period using a network of 258 multilevel sampling wells. The tracer concentration distribution of the plume at the conclusion of the experiment was highly asymmetric in the longitudinal direction. The peak tracer concentration was located only 7 m from the injection point, while the advancing side of the plume extended downgradient a distance of more than 260 m. The extreme skewness of the plume was caused by large scale spatial variations in the mean groundwater velocity along the plume travel path produced by the approximate two order-of-magnitude increase in the mean hydraulic conductivity between the near-field and far-field regions of the experimental site. The tracer mass balance during the experiment showed a declining trend between sampling events with approximately 50 percent of the injected tracer mass unaccounted for at the end of the experiment. Laboratory column experiments indicated that approximately 20 percent of the tracer mass was adsorbed to the aquifer matrix. The remaining 30 percent of the missing tracer mass was attributed to incomplete sampling coverage of the plume, particularly on the advancing side, and to a sampling bias produced by the multilevel samplers. (Author) (17 refs., 3 tabs., 11 figs.)

  8. Allocation and sequencing in 1-out-of-N heterogeneous cold-standby systems: Multi-objective harmony search with dynamic parameters tuning

    International Nuclear Information System (INIS)

    Valaei, M.R.; Behnamian, J.

    2017-01-01

    A redundancy allocation is a famous problem in reliability sciences. A lot of researcher investigated about this problem, but a few of them focus on heterogeneous 1-out-of-N: G cold-standby redundancy in each subsystem. This paper considers a redundancy allocation problem (RAP) and standby element sequencing problem (SESP) for 1-out-of-N: G heterogeneous cold-standby system, simultaneously. Moreover, here, maximizing reliability of cold-standby allocation and minimizing cost of buying and time-independent elements are considered as two conflict objectives. This problem is NP-Hard and consequently, devizing a metaheuristic to solve this problem, especially for large-sized instances, is highly desirable. In this paper, we propose a multi-objective harmony search. Based on Taguchi experimental design, we, also, present a new parameters tuning method to improve the proposed algorithm. - Graphical abstract: Example of solution encoding. - Highlights: • This paper considers a redundancy allocation and standby element sequencing problem. • To solve this problem, a multi-objective harmony search algorithm is proposed. • Dynamic parameters tuning method is applied to improved the algorithm. • With this method, sensitivity of the algorithm to initial parameters is reduced.

  9. Fuel cycle parameters for strategy studies

    International Nuclear Information System (INIS)

    Archinoff, G.H.

    1979-05-01

    This report summarizes seven fuel cycle parameters (efficiency, specific power, burnup, equilibrium net fissile feed, equilibrium net fissile surplus, first charge fissile content, and whether or not fuel reprocessing is required) to be used in long-term strategy analyses of fuel cycles based on natural UO 2 , low enriched uranium, mixed oxides, plutonium topped thorium, uranium topped thorium, and the fast breeder oxide cycle. (LL)

  10. Heterogeneous studies in pulping of wood: Modelling mass transfer of alkali

    OpenAIRE

    Simão, João P. F.; Egas, Ana P. V.; Carvalho, M. Graça; Baptista, Cristina M. S. G.; Castro, José Almiro A. M.

    2008-01-01

    In this paper a heterogeneous lumped parameter model is proposed to describe the mass transfer of effective alkali during the kraft pulping of wood. This model, based on the spatial mean of the concentration profile of effective alkali along the chip thickness, enables the estimation of the effective diffusion coefficient that characterizes the internal resistance to mass transfer and the contribution of the external resistance to mass transfer which has often been neglected. http://www.sc...

  11. The interplay between dynamic heterogeneities and structure of bulk liquid water: A molecular dynamics simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Demontis, Pierfranco; Suffritti, Giuseppe B. [Dipartimento di Chimica e Farmacia, Università degli studi di Sassari, Sassari (Italy); Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Unità di ricerca di Sassari, Via Vienna, 2, I-07100 Sassari (Italy); Gulín-González, Jorge [Grupo de Matemática y Física Computacionales, Universidad de las Ciencias Informáticas (UCI), Carretera a San Antonio de los Baños, Km 21/2, La Lisa, La Habana (Cuba); Masia, Marco [Dipartimento di Chimica e Farmacia, Università degli studi di Sassari, Sassari (Italy); Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Unità di ricerca di Sassari, Via Vienna, 2, I-07100 Sassari (Italy); Istituto Officina dei Materiali del CNR, UOS SLACS, Via Vienna 2, 07100 Sassari (Italy); Sant, Marco [Dipartimento di Chimica e Farmacia, Università degli studi di Sassari, Sassari (Italy)

    2015-06-28

    In order to study the interplay between dynamical heterogeneities and structural properties of bulk liquid water in the temperature range 130–350 K, thus including the supercooled regime, we use the explicit trend of the distribution functions of some molecular properties, namely, the rotational relaxation constants, the atomic mean-square displacements, the relaxation of the cross correlation functions between the linear and squared displacements of H and O atoms of each molecule, the tetrahedral order parameter q and, finally, the number of nearest neighbors (NNs) and of hydrogen bonds (HBs) per molecule. Two different potentials are considered: TIP4P-Ew and a model developed in this laboratory for the study of nanoconfined water. The results are similar for the dynamical properties, but are markedly different for the structural characteristics. In particular, for temperatures higher than that of the dynamic crossover between “fragile” (at higher temperatures) and “strong” (at lower temperatures) liquid behaviors detected around 207 K, the rotational relaxation of supercooled water appears to be remarkably homogeneous. However, the structural parameters (number of NNs and of HBs, as well as q) do not show homogeneous distributions, and these distributions are different for the two water models. Another dynamic crossover between “fragile” (at lower temperatures) and “strong” (at higher temperatures) liquid behaviors, corresponding to the one found experimentally at T{sup ∗} ∼ 315 ± 5 K, was spotted at T{sup ∗} ∼ 283 K and T{sup ∗} ∼ 276 K for the TIP4P-Ew and the model developed in this laboratory, respectively. It was detected from the trend of Arrhenius plots of dynamic quantities and from the onset of a further heterogeneity in the rotational relaxation. To our best knowledge, it is the first time that this dynamical crossover is detected in computer simulations of bulk water. On the basis of the simulation results, the possible

  12. Seismic wave propagation in heterogeneous multiphasic media: numerical modelling, sensibility and inversion of poro-elastic parameters

    International Nuclear Information System (INIS)

    Dupuy, B.

    2011-11-01

    Seismic wave propagation in multiphasic porous media have various environmental (natural risks, geotechnics, groundwater pollutions...) and resources (aquifers, oil and gas, CO 2 storage...) issues. When seismic waves are crossing a given material, they are distorted and thus contain information on fluid and solid phases. This work focuses on the characteristics of seismic waves propagating in multiphasic media, from the physical complex description to the parameter characterisation by inversion, including 2D numerical modelling of the wave propagation. The first part consists in the description of the physics of multiphasic media (each phase and their interactions), using several up-scaling methods, in order to obtain an equivalent mesoscale medium defined by seven parameters. Thus, in simple porosity saturated media and in complex media (double porosity, patchy saturation, visco-poro-elasticity), I can compute seismic wave propagation without any approximation. Indeed, I use a frequency-space domain for the numerical method, which allows to consider all the frequency dependent terms. The spatial discretization employs a discontinuous finite elements method (discontinuous Galerkin), which allows to take into account complex interfaces.The computation of the seismic attributes (velocities and attenuations) of complex porous media shows strong variations in respect with the frequency. Waveforms, computed without approximation, are strongly different if we take into account the full description of the medium or an homogenisation by averages. The last part of this work deals with the poro-elastic parameters characterisation by inversion. For this, I develop a two-steps method: the first one consists in a classical inversion (tomography, full waveform inversion) of seismograms data to obtain macro-scale parameters (seismic attributes). The second step allows to recover, from the macro-scale parameters, the poro-elastic micro-scale properties. This down-scaling step

  13. Overview of homogeneous versus heterogeneous core configuration trade-off studies

    International Nuclear Information System (INIS)

    Chang, Y.I.

    1982-01-01

    The most significant development in core design trend in the U.S. LMFBR program has been the increased attention given to the heterogeneous core design concept. In recent years, numerous core configuration trade-off studies have been carried out to quantify advantages and disadvantages of the heterogeneous concept relative to the homogeneous concept, and a consensus is emerging among the U.S. core designers. It appears that the technical and economic performance differences between homogeneous and heterogeneous core designs are very small; however, the heterogeneous concept provides a definite safety/licensing advantage. he technical and economic performance comparison between homogeneous and heterogeneous core configurations is difficult to quantify. In fact, in most cases, the perceived advantages and/or disadvantages are dictated by the consistency in the comparison (optimized for one concept versus non-optimized for the other, etc.) rather than by any inherent differences. Some of the technical and economic issues relevant to the homogeneous versus heterogeneous comparison are summarized

  14. Overview of homogeneous versus heterogeneous core configuration trade-off studies

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y I [Applied Physics Division, Argonne National Laboratory, Argonne, IL (United States)

    1982-01-01

    The most significant development in core design trend in the U.S. LMFBR program has been the increased attention given to the heterogeneous core design concept. In recent years, numerous core configuration trade-off studies have been carried out to quantify advantages and disadvantages of the heterogeneous concept relative to the homogeneous concept, and a consensus is emerging among the U.S. core designers. It appears that the technical and economic performance differences between homogeneous and heterogeneous core designs are very small; however, the heterogeneous concept provides a definite safety/licensing advantage. he technical and economic performance comparison between homogeneous and heterogeneous core configurations is difficult to quantify. In fact, in most cases, the perceived advantages and/or disadvantages are dictated by the consistency in the comparison (optimized for one concept versus non-optimized for the other, etc.) rather than by any inherent differences. Some of the technical and economic issues relevant to the homogeneous versus heterogeneous comparison are summarized.

  15. An experimental study of the heterogeneous LMFBR core using FCA assemblies with axial internal blanket

    International Nuclear Information System (INIS)

    Nakano, M.; Iijima, S.; Shirakata, K.; Hirota, J.

    1980-01-01

    To investigate physics properties of the heterogeneous LMFBR core and to examine the reliability of the current data and method for heterogeneous core configuration, an experimental study has been made on FCA VII-3 assemblies which have an internal blanket (IB) at midplane of the cylindrical core. Systematic experiments were carried out on the heterogeneous cores whose IBs were different in composition and thickness. A homogeneous core was also built to compare the results with those obtained on the heterogeneous cores. The sodium-void worth is not sensitive to the composition of IB. The positive void worth in the core of the 40 cm IB is lowered by about 40% compared with that in the homogeneous core. The analysis was made using the JAERI-Fast Set Version II and the diffusion code CITATION. Directional diffusion coefficients were used to take account of the axial streaming. To evaluate transport effects, the S 4 calculation was made. Comparison between the calculated and experimental results reveals the following: ksub(eff) and Pu worth in the core are not well predicted for the heterogeneous core, although they are represented satisfactorily for the homogeneous core. Reaction rates sensitive to the low-energy neutron are underestimated in the IB when they are normalized in the core. Sodium-void worths are fairly well predicted. However, the positive void worth in the heterogeneous core is underestimated, while that in the homogeneous core is overestimated. (author)

  16. Study and analysis of drift chamber parameters

    International Nuclear Information System (INIS)

    Martinez Laso, L.

    1988-01-01

    The present work deals mainly with drift chambers. In the first chapter a summary of drift chamber properties is presented. The information has been collected from the extensive bibliography available in this field. A very simple calculation procedure of drift chamber parameters has been developed and is presented in detail in the second chapter. Some prototypes have been made following two geometries (multidrift chamber and Z-chambers). Several installations have been used for test and calibration of these prototypes. A complete description of these installations is given in the third chapter. Cosmic rays, beta particles from a Ru106 radiactive source and a test beam in the WA (West Area) of SPS at CERN have been used for experimental purposes. The analysis and the results are described for the different setups. The experimental measurements have been used to produce a complete cell parametrization (position as function of drift time) and to obtain spatial resolution values (in the range of 200-250 um). Experimental results are in good agreement with numerical calculations. (Author)

  17. Heterogeneity within autism spectrum disorders: what have we learned from neuroimaging studies?

    Directory of Open Access Journals (Sweden)

    Rhoshel Krystyna Lenroot

    2013-10-01

    Full Text Available Autism spectrum disorders (ASD display significant heterogeneity. Although most neuroimaging studies in ASD have been designed to identify commonalities among affected individuals, rather than differences, some studies have explored variation within ASD. There have been two general types of approaches used for this in the neuroimaging literature to date: comparison of subgroups within ASD, and analyses using dimensional measures to link clinical variation to brain differences. This review focuses on structural and functional magnetic resonance imaging studies that have used these approaches to begin to explore heterogeneity between individuals with ASD. Although this type of data is yet sparse, recognition is growing of the limitations of behaviourally defined categorical diagnoses for understanding neurobiology. Study designs that are more informative regarding the sources of heterogeneity in ASD have the potential to improve our understanding of the neurobiological processes underlying ASD.

  18. Air flow and pollution in a real, heterogeneous urban street canyon: A field and laboratory study

    Science.gov (United States)

    Karra, Styliani; Malki-Epshtein, Liora; Neophytou, Marina K.-A.

    2017-09-01

    In this work we investigate the influence of real world conditions, including heterogeneity and natural variability of background wind, on the air flow and pollutant concentrations in a heterogeneous urban street canyon using both a series of field measurements and controlled laboratory experiments. Field measurements of wind velocities and Carbon Monoxide (CO) concentrations were taken under field conditions in a heterogeneous street in a city centre at several cross-sections along the length of the street (each cross-section being of different aspect ratio). The real field background wind was in fact observed to be highly variable and thus different Intensive Observation Periods (IOPs) represented by a different mean wind velocity and different wind variability were defined. Observed pollution concentrations reveal high sensitivity to local parameters: there is a bias towards the side closer to the traffic lane; higher concentrations are found in the centre of the street as compared to cross-sections closer to the junctions; higher concentrations are found at 1.5 height from the ground than at 2.5 m height, all of which are of concern regarding pedestrian exposure to traffic-related pollution. A physical model of the same street was produced for the purpose of laboratory experiments, making some geometrical simplifications of complex volumes and extrusions. The physical model was tested in an Atmospheric Boundary Layer water channel, using simultaneously Particle Image Velocimetry (PIV) and Planar Laser Induced Fluorescence (PLIF), for flow visualisation as well as for quantitative measurement of concentrations and flow velocities. The wind field conditions were represented by a steady mean approach velocity in the laboratory simulation (essentially representing periods of near-zero wind variability). The laboratory investigations showed a clear sensitivity of the resulting flow field to the local geometry and substantial three-dimensional flow patterns were

  19. Microbial Genetic Memory to Study Heterogeneous Soil Processes

    Science.gov (United States)

    Fulk, E. M.; Silberg, J. J.; Masiello, C. A.

    2017-12-01

    Microbes can be engineered to sense environmental conditions and produce a detectable output. These microbial biosensors have traditionally used visual outputs that are difficult to detect in soil. However, recently developed gas-producing biosensors can be used to noninvasively monitor complex soil processes such as horizontal gene transfer or cell-cell signaling. While these biosensors report on the fraction of a microbial population exposed to a process or chemical signal at the time of measurement, they do not record a "memory" of past exposure. Synthetic biologists have recently developed a suite of genetically encoded memory circuits capable of reporting on historical exposure to the signal rather than just the current state. We will provide an overview of the microbial memory systems that may prove useful to studying microbial decision-making in response to environmental conditions. Simple memory circuits can give a yes/no report of any past exposure to the signal (for example anaerobic conditions, osmotic stress, or high nitrate concentrations). More complicated systems can report on the order of exposure of a population to multiple signals or the experiences of spatially distinct populations, such as those in root vs. bulk soil. We will report on proof-of-concept experiments showing the function of a simple permanent memory system in soil-cultured microbes, and we will highlight additional applications. Finally, we will discuss challenges still to be addressed in applying these memory circuits for biogeochemical studies.

  20. Multi-parameter study of gammas capture

    International Nuclear Information System (INIS)

    Samama, R.; Nifenecker, H.; Carlos, P.; Delaitre, B.

    1966-06-01

    This equipment is intended for analyzing, recording, and reading simultaneous information from several 'gamma' detectors. It allows multiparameter study of γ-γ cascades emitted after thermal neutrons capture. (authors) [fr

  1. Studies on mixed metal oxides solid solutions as heterogeneous catalysts

    Directory of Open Access Journals (Sweden)

    H. R. Arandiyan

    2009-03-01

    Full Text Available In this work, a series of perovskite-type mixed oxide LaMo xV1-xO3+δ powder catalysts (x = 0, 0.1, 0.3, 0.5, 0.7, 0.9, and 1.0, with 0.5 < δ < 1.5, prepared by the sol-gel process and calcined at 750ºC, provide an attractive and effective alternative means of synthesizing materials with better control of morphology. Structures of resins obtained during the gel formation process by FT-IR spectroscopy and XRD analysis showed that all the LaMo xV1-xO3+δ samples are single phase perovskite-type solid solutions. The surface area (BET between 2.5 - 5.0 m²/g (x = 0.1 and 1.0 respectively increases with increasing Mo ratio in the samples. They show high purity, good chemical homogeneity, and lower calcinations temperatures as compared with the solid-state chemistry route. SEM coupled to EDS and thermogravimetric analysis/differential thermal analyses (TGA/DTA have been carried out in order to evaluate the homogeneity of the catalyst. Finally, the experimental studies show that the calcination temperature and Mo content exhibited a significant influence on catalytic activity. Among the LaMo xV1-xO3+δ samples, LaMo0.7V0.3O4.2 showed the best catalytic activity for the topic reaction and the best activity and stability for ethane reforming at 850ºC under 8 bar.

  2. Exacerbation heterogeneity in COPD: subgroup analyses from the FLAME study

    Directory of Open Access Journals (Sweden)

    Vogelmeier CF

    2018-04-01

    Full Text Available Claus F Vogelmeier,1 Kenneth R Chapman,2 Marc Miravitlles,3 Nicolas Roche,4 Jørgen Vestbo,5 Chau Thach,6 Donald Banerji,6 Robert Fogel,6 Francesco Patalano,7 Petter Olsson,8 Konstantinos Kostikas,7 Jadwiga A Wedzicha9 1Member of the German Center for Lung Research (DZL, Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, Marburg, Germany; 2Asthma and Airway Centre, University Health Network and University of Toronto, Toronto, ON, Canada; 3Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 4Service de Pneumologie AP-HP, Cochin Hospital, University Paris Descartes (EA2511, Paris, France; 5Institute of Infection, Immunity and Respiratory Medicine, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK; 6Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 7Novartis Pharma AG, Basel, Switzerland; 8Novartis Sverige AB, Täby, Sweden; 9National Heart and Lung Institute, Imperial College London, London, UK Background: The FLAME study compared once-daily indacaterol/glycopyrronium (IND/GLY 110/50 µg with twice-daily salmeterol/fluticasone (SFC 50/500 µg in symptomatic patients with moderate to very severe COPD and a history of exacerbations in the previous year. Methods: This prespecified and post hoc subgroup analysis evaluated treatment efficacy on 1 moderate/severe exacerbations according to prior exacerbation history and treatment, and 2 types of exacerbations according to health care resource utilization (HCRU during 1-year follow-up. Results: IND/GLY reduced the rate of moderate/severe exacerbations versus SFC in patients with a history of 1 exacerbation (rate ratio [RR]: 0.83, 95% CI: 0.75–0.93, ≥2 exacerbations (RR: 0.85, 95% CI: 0.70–1.03 and ≥2 exacerbations or ≥1 hospitalization in the previous year (RR: 0.86, 95% CI: 0.74

  3. Simulation study on heterogeneous variance adjustment for observations with different measurement error variance

    DEFF Research Database (Denmark)

    Pitkänen, Timo; Mäntysaari, Esa A; Nielsen, Ulrik Sander

    2013-01-01

    of variance correction is developed for the same observations. As automated milking systems are becoming more popular the current evaluation model needs to be enhanced to account for the different measurement error variances of observations from automated milking systems. In this simulation study different...... models and different approaches to account for heterogeneous variance when observations have different measurement error variances were investigated. Based on the results we propose to upgrade the currently applied models and to calibrate the heterogeneous variance adjustment method to yield same genetic......The Nordic Holstein yield evaluation model describes all available milk, protein and fat test-day yields from Denmark, Finland and Sweden. In its current form all variance components are estimated from observations recorded under conventional milking systems. Also the model for heterogeneity...

  4. Periodically-modulated inhibition of living pacemaker neurons--III. The heterogeneity of the postsynaptic spike trains, and how control parameters affect it.

    Science.gov (United States)

    Segundo, J P; Vibert, J F; Stiber, M

    1998-11-01

    Codings involving spike trains at synapses with inhibitory postsynaptic potentials on pacemakers were examined in crayfish stretch receptor organs by modulating presynaptic instantaneous rates periodically (triangles or sines; frequencies, slopes and depths under, respectively, 5.0 Hz, 40.0/s/s and 25.0/s). Timings were described by interspike and cross-intervals ("phases"); patterns (dispersions, sequences) and forms (timing classes) were identified using pooled graphs (instant along the cycle when a spike occurs vs preceding interval) and return maps (plots of successive intervals). A remarkable heterogeneity of postsynaptic intervals and phases characterizes each modulation. All cycles separate into the same portions: each contains a particular form and switches abruptly to the next. Forms differ in irregularity and predictability: they are (see text) "p:q alternations", "intermittent", "phase walk-throughs", "messy erratic" and "messy stammering". Postsynaptic cycles are asymmetric (hysteresis). This contrasts with the presynaptic homogeneity, smoothness and symmetry. All control parameters are, individually and jointly, strongly influential. Presynaptic slopes, say, act through a postsynaptic sensitivity to their magnitude and sign; when increasing, hysteresis augments and forms change or disappear. Appropriate noise attenuates between-train contrasts, providing modulations are under 0.5 Hz. Postsynaptic natural intervals impose critical time bases, separating presynaptic intervals (around, above or below them) with dissimilar consequences. Coding rules are numerous and have restricted domains; generalizations are misleading. Modulation-driven forms are trendy pacemaker-driven forms. However, dissimilarities, slight when patterns are almost pacemaker, increase as inhibition departs from pacemaker and incorporate unpredictable features. Physiological significance-(1) Pacemaker-driven forms, simple and ubiquitous, appear to be elementary building blocks of

  5. A study of heterogeneity of environmental variance for slaughter weight in pigs

    DEFF Research Database (Denmark)

    Ibánez-Escriche, N; Varona, L; Sorensen, D

    2008-01-01

    This work presents an analysis of heterogeneity of environmental variance for slaughter weight (175 days) in pigs. This heterogeneity is associated with systematic and additive genetic effects. The model also postulates the presence of additive genetic effects affecting the mean and environmental...... variance. The study reveals the presence of genetic variation at the level of the mean and the variance, but an absence of correlation, or a small negative correlation, between both types of additive genetic effects. In addition, we show that both, the additive genetic effects on the mean and those...... on environmental variance have an important influence upon the future economic performance of selected individuals...

  6. Study of photodissociation parameters of carboxyhemoglobin

    International Nuclear Information System (INIS)

    Kuz'min, V V; Salmin, V V; Provorov, A S; Salmina, A B

    2008-01-01

    The general properties of photodissociation of carboxyhemoglobin (HbCO) in buffer solutions of whole human blood are studied by the flash photolysis method on a setup with intersecting beams. It is shown that the efficiency of photoinduced dissociation of the HbCO complex virtually linearly depends on the photolytic irradiation intensity for the average power density not exceeding 45 mW cm -2 . The general dissociation of the HbCO complex in native conditions occurs in a narrower range of values of the saturation degree than in model experiments with the hemoglobin solution. The dependence of the pulse photolysis efficiency of HbCO on the photolytic radiation wavelength in the range from 550 to 585 nm has a broad bell shape. The efficiency maximum corresponds to the electronic Q transition (porphyrin π-π* absorption) in HbCO at a wavelength of 570 nm. No dissociation of the complex was observed under given experimental conditions upon irradiation of solutions by photolytic radiation at wavelengths above 585 nm. (laser applications and other topics in quantum electronics)

  7. The study of multiple PET reconstructed parameter

    International Nuclear Information System (INIS)

    Yin, D. Y.; Tian, J.

    2000-01-01

    PET, compared with SPECT, uses some similar techniques in image reconstruction, on the other hand, there are some difference on the techniques. A phantom experiment was conducted and the result was evaluated objectively through quantitative analysis in order to find ideal filter and cutoff frequency (Fc) for clinical application. The PET phantom have 6 solid inserts (cold) in the upper half and 6 hollow ones (hot) in the lower part. The middle insert is 1cm in diameter, the outer five have diameters of 1 to 3cm respectively. The phantom filled with 111 MBq 18 FDG and studied with segmentation acquisition. 25 set of images were reconstructed using HANN, HAMM, PARZEN, BUTTERWORTH, BUTTERWORTH2 filter and 0.1, 0.2, 0.3, 0.4, 0.5 Fe successively.A ROI of 4*4 pixels was drawn over middle 1 cm, outer 1cm, 3 cm cold column area and background area, the ratio between the ROI of cold column and background was calculated to evaluate the image contrast. A ROI of 15*15 pixels was drawn on the background area to get s.d as a judgement of image noise. A profile curve was drawn on the hollow column of middle 1 cm and outer 1 cm and their FWHM were compared with the real diameter to reflect linearity. With the same Fc, the contrast using HANN and HAMM filter was superior to other filter, The effect of the filter on image noise is listed in high to low order as HAMM, HANN, BUTTERWORTH, PARZEN and BUTTERWORTH2. The higher Fc, the higher image noise. The FWHM will increases as the Fc value decreases. With same Fc, the FWHM of different filter from small to big is HAMM, BUTTERWORTH, HANN, PARZEN, BUTTERWORTH2. The outer FWHM is larger than the middle one. For brain image, we suggest HAMM and HANN with Fc 0.3, 0.4 For image demanding lower resolution, we suggest BUTTERWORTH with Fc 0.4, 0.5, 2. For hot image, we can increase Fc to get high resolution. The FWHM value closed to the real value when HANN, HANN with Fc 0.3 and BUTTERWORTH with Fc 0.2. The 5% difference of FWHM between

  8. Nanolithographic Fabrication and Heterogeneous Reaction Studies ofTwo-Dimensional Platinum Model Catalyst Systems

    Energy Technology Data Exchange (ETDEWEB)

    Contreras, Anthony Marshall [Univ. of California, Berkeley, CA (United States)

    2006-05-20

    In order to better understand the fundamental components that govern catalytic activity, two-dimensional model platinum nanocatalyst arrays have been designed and fabricated. These catalysts arrays are meant to model the interplay of the metal and support important to industrial heterogeneous catalytic reactions. Photolithography and sub-lithographic techniques such as electron beam lithography, size reduction lithography and nanoimprint lithography have been employed to create these platinum nanoarrays. Both in-situ and ex-situ surface science techniques and catalytic reaction measurements were used to correlate the structural parameters of the system to catalytic activity.

  9. Small studies are more heterogeneous than large ones: a meta-meta-analysis

    NARCIS (Netherlands)

    Hout, J. in't; Ioannidis, J.P.; Borm, G.F.; Goeman, J.J.

    2015-01-01

    OBJECTIVES: Between-study heterogeneity plays an important role in random-effects models for meta-analysis. Most clinical trials are small, and small trials are often associated with larger effect sizes. We empirically evaluated whether there is also a relationship between trial size and

  10. Characterization of Tumor Heterogeneity by Texture Analysis in 18F-FDG PET images: A Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    Manso, M.; Martino, M.E.; Rodriguez, E.A.; Landaeta, L.C.; Carreras, J.L.; Calvo, F.A.; Desco, M.; Pascau, J.; Muñoz-Barrutia, M.

    2016-07-01

    2-Deoxy-2-[18F]-fluoro-D-glucose (FDG) positron emission tomography (PET) is often used in clinic for cancer diagnosis, staging, therapy planning and monitoring. Alternative features to the classical semi-quantitative variables have been recently proposed to study the heterogeneity of tumors. The method to extract such characteristics is texture analysis, which quantifies variations of uptake distribution within the lesions. Methods: Fifty-three head and neck and twelve rectal cancer patients were included in the analysis. A workflow in an open-source software, 3D slicer, was designed and expert clinicians were trained on its use, sixty six features were calculated including metabolic and texture parameters. Statistical analysis and dimensionality reduction techniques were performed on the data. Results: After observing a high correlation between variables, dimensions were reduced to five and three independent components for head and neck and rectal cancer cohort, respectively. Conclusion: Tumor heterogeneity parameters could be expressing important information about tumor and cancer disease, information that could be used to assess disease staging, patients’ prognosis, therapy plan and survival. (Author)

  11. Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer.

    Science.gov (United States)

    Lubbock, Alexander L R; Stewart, Grant D; O'Mahony, Fiach C; Laird, Alexander; Mullen, Peter; O'Donnell, Marie; Powles, Thomas; Harrison, David J; Overton, Ian M

    2017-06-26

    Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk stratification has sought to overcome the performance ceiling encountered by methods restricted to traditional clinical parameters. However, replication of results has proven challenging, and intratumoural heterogeneity (ITH) may confound attempts at tissue-based stratification. We investigated the influence of confounding ITH on the performance of a novel molecular prognostic model, enabled by pathologist-guided multiregion sampling (n = 183) of geographically separated mccRCC cohorts from the SuMR trial (development, n = 22) and the SCOTRRCC study (validation, n = 22). Tumour protein levels quantified by reverse phase protein array (RPPA) were investigated alongside clinical variables. Regularised wrapper selection identified features for Cox multivariate analysis with overall survival as the primary endpoint. The optimal subset of variables in the final stratification model consisted of N-cadherin, EPCAM, Age, mTOR (NEAT). Risk groups from NEAT had a markedly different prognosis in the validation cohort (log-rank p = 7.62 × 10 -7 ; hazard ratio (HR) 37.9, 95% confidence interval 4.1-353.8) and 2-year survival rates (accuracy = 82%, Matthews correlation coefficient = 0.62). Comparisons with established clinico-pathological scores suggest favourable performance for NEAT (Net reclassification improvement 7.1% vs International Metastatic Database Consortium score, 25.4% vs Memorial Sloan Kettering Cancer Center score). Limitations include the relatively small cohorts and associated wide confidence intervals on predictive performance. Our multiregion sampling approach enabled investigation of NEAT validation when limiting the number of samples analysed per tumour, which significantly degraded performance

  12. A Comparative Study of Distribution System Parameter Estimation Methods

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yannan; Williams, Tess L.; Gourisetti, Sri Nikhil Gup

    2016-07-17

    In this paper, we compare two parameter estimation methods for distribution systems: residual sensitivity analysis and state-vector augmentation with a Kalman filter. These two methods were originally proposed for transmission systems, and are still the most commonly used methods for parameter estimation. Distribution systems have much lower measurement redundancy than transmission systems. Therefore, estimating parameters is much more difficult. To increase the robustness of parameter estimation, the two methods are applied with combined measurement snapshots (measurement sets taken at different points in time), so that the redundancy for computing the parameter values is increased. The advantages and disadvantages of both methods are discussed. The results of this paper show that state-vector augmentation is a better approach for parameter estimation in distribution systems. Simulation studies are done on a modified version of IEEE 13-Node Test Feeder with varying levels of measurement noise and non-zero error in the other system model parameters.

  13. Habitat heterogeneity of hadal trenches: Considerations and implications for future studies

    Science.gov (United States)

    Stewart, Heather A.; Jamieson, Alan J.

    2018-02-01

    The hadal zone largely comprises a series of subduction trenches that do not form part of the continental shelf-slope rise to abyssal plain continuum. Instead they form geographically isolated clusters of deep-sea (6000-11,000 m water depth) environments. There is a growing realization in hadal science that ecological patterns and processes are not driven solely by responses to hydrostatic pressure, with comparable levels of habitat heterogeneity as observed in other marine biozones. Furthermore, this heterogeneity can be expressed at multiple scales from inter-trench levels (degrees of geographical isolation, and biochemical province), to intra-trench levels (variation between trench flanks and axis), topographical features within the trench interior (sedimentary basins, ridges, escarpments, 'deeps', seamounts) to the substrate of the trench floor (seabed-sediment composition, mass movement deposits, bedrock outcrop). Using best available bathymetry data combined with the largest lander-derived imaging dataset that spans the full depth range of three hadal trenches (including adjacent slopes); the Mariana, Kermadec and New Hebrides trenches, the topographic variability, fine-scale habitat heterogeneity and distribution of seabed sediments of these three trenches have been assessed for the first time. As well as serving as the first descriptive study of habitat heterogeneity at hadal depths, this study also provides guidance for future hadal sampling campaigns taking into account geographic isolation, total trench particulate organic matter flux, maximum water depth and area.

  14. Heterogeneous reactors

    International Nuclear Information System (INIS)

    Moura Neto, C. de; Nair, R.P.K.

    1979-08-01

    The microscopic study of a cell is meant for the determination of the infinite multiplication factor of the cell, which is given by the four factor formula: K(infinite) = n(epsilon)pf. The analysis of an homogeneous reactor is similar to that of an heterogeneous reactor, but each factor of the four factor formula can not be calculated by the formulas developed in the case of an homogeneous reactor. A great number of methods was developed for the calculation of heterogeneous reactors and some of them are discussed. (Author) [pt

  15. Study on distributed generation algorithm of variable precision concept lattice based on ontology heterogeneous database

    Science.gov (United States)

    WANG, Qingrong; ZHU, Changfeng

    2017-06-01

    Integration of distributed heterogeneous data sources is the key issues under the big data applications. In this paper the strategy of variable precision is introduced to the concept lattice, and the one-to-one mapping mode of variable precision concept lattice and ontology concept lattice is constructed to produce the local ontology by constructing the variable precision concept lattice for each subsystem, and the distributed generation algorithm of variable precision concept lattice based on ontology heterogeneous database is proposed to draw support from the special relationship between concept lattice and ontology construction. Finally, based on the standard of main concept lattice of the existing heterogeneous database generated, a case study has been carried out in order to testify the feasibility and validity of this algorithm, and the differences between the main concept lattice and the standard concept lattice are compared. Analysis results show that this algorithm above-mentioned can automatically process the construction process of distributed concept lattice under the heterogeneous data sources.

  16. Study of mitochondria D-loop gene to detect the heterogeneity of gemak in Turnicidae family

    Science.gov (United States)

    Setiati, N.; Partaya

    2018-03-01

    As a part of life biodiversity, birds in Turnicidae family should be preserved from the extinction and its type heterogeneity decline. One effort for giving the strategic base of plasma nutfah conservation is through genetic heterogeneity study. The aim of the research is to analyze D-loop gen from DNA mitochondria of gemak bird in Turnicidae family molecularly. From the result of the analysis, it may be known the genetic heterogeneity of gemak bird based on the sequence of D-loop gen. The collection of both types of gemak of Turnicidae family is still easy since we can find them in ricefield area after harvest particularly for Gemakloreng (Turnix sylvatica), it means while gemak tegalan (Turnixsusciator) is getting difficult to find. Based on the above DNA quantification standard, the blood sample of Gemak in this research is mostly grouped into pure blood (ranges from 1,63 – 1,90), and it deserves to be used for PCR analysis. The sequencing analysis has not detected the sequence of nucleotide completely. However, it indicates sequence polymorphism of base as the arranger of D-loop gen. D-loop gen may identify genetic heterogeneity of gemak bird of Turnicidae family, but it is necessary to perform further sequencing analysis with PCR-RFLP technique. This complete nucleotide sequence is obtained and easy to detect after being cut restriction enzyme.

  17. First-principles study on ferrite/TiC heterogeneous nucleation interface

    International Nuclear Information System (INIS)

    Yang, Jian; Zhang, Pengfei; Zhou, Yefei; Guo, Jing; Ren, Xuejun; Yang, Yulin; Yang, Qingxiang

    2013-01-01

    Highlights: ► Interface stability of ferrite (1 0 0)/TiC (1 0 0) was studied. ► The effectiveness of TiC as the heterogeneous nuclei of ferrite was analyzed. ► Ti-termination and C-termination are the two binding modes for ferrite/TiC interface. ► Interfacial energy of the Ti-termination is larger than that of the C-termination. ► On C-termination, ability of TiC promotes ferrite heterogeneous nucleation is strong. -- Abstract: Interface atomic structure, bonding character, cohesive energy and interfacial energy of ferrite (1 0 0)/TiC (1 0 0) were studied using a first-principles density functional plane-wave ultrasoft pseudopotential method. Meanwhile, the effectiveness of TiC as the heterogeneous nuclei of ferrite was analyzed. The results indicated that, TiC bonding is dominated by the C-2p, C-2s and Ti-3d electrons, which exhibits high covalency. With increase of the atomic layers, the interfacial energies of ferrite and TiC are both declined rapidly and stabilized gradually. There are two binding modes for TiC as the heterogeneous nuclei of ferrite, which are Fe atoms above the Ti atoms (Ti-termination) and Fe atoms above the C atoms (C-termination). Interfacial energy of the Ti-termination is larger than that of the C-termination, which means that for Fe atoms above the C atoms, the ability of TiC promotes ferrite heterogeneous nucleation on its surface is larger than that for Fe atoms above the Ti atoms

  18. The reaction between iodine and organic coatings under severe PWR accident conditions. An experimental parameter study

    Energy Technology Data Exchange (ETDEWEB)

    Hellmann, S; Funke, F; Greger, G U; Bleier, A; Morell, W [Siemens AG, Power Generation Group, Erlangen (Germany)

    1996-12-01

    An extensive experimental parameter study was performed on the deposition and on the resuspension kinetics in the reaction system iodine/organically coated surfaces. Both reactions in the gas phase and in the liquid phase were investigated and kinetic rate constants suitable for modelling were derived. Previous experimental studies on the reaction of iodine with organic coated surfaces were mostly limited to temperatures below 100{sup o}C. Thus, this parameter study aims at filling a gap and providing kinetic data on heterogeneous reactions with organic surfaces in the accident-relevant temperature range of 100-160{sup o}C. Two types of laboratory experiments carried out at Siemens/KWU using coatings representative for German power plants (epoxy-tape paint), namely gas phase tests and liquid phase tests. (author) 6 figs., 6 tabs., 5 refs.

  19. An experimental study on effect of process parameters in deep ...

    African Journals Online (AJOL)

    The effects of various deep drawing process parameters were determined by experimental study with the use of Taguchi fractional factorial design and analysis of variance for AA6111 Aluminum alloy. The optimum process parameters were determined based on their influence on the thickness variation at different regions ...

  20. Group heterogeneity increases the risks of large group size: a longitudinal study of productivity in research groups.

    Science.gov (United States)

    Cummings, Jonathon N; Kiesler, Sara; Bosagh Zadeh, Reza; Balakrishnan, Aruna D

    2013-06-01

    Heterogeneous groups are valuable, but differences among members can weaken group identification. Weak group identification may be especially problematic in larger groups, which, in contrast with smaller groups, require more attention to motivating members and coordinating their tasks. We hypothesized that as groups increase in size, productivity would decrease with greater heterogeneity. We studied the longitudinal productivity of 549 research groups varying in disciplinary heterogeneity, institutional heterogeneity, and size. We examined their publication and citation productivity before their projects started and 5 to 9 years later. Larger groups were more productive than smaller groups, but their marginal productivity declined as their heterogeneity increased, either because their members belonged to more disciplines or to more institutions. These results provide evidence that group heterogeneity moderates the effects of group size, and they suggest that desirable diversity in groups may be better leveraged in smaller, more cohesive units.

  1. Study on evaluation method for heterogeneous sedimentary rocks based on forward model

    International Nuclear Information System (INIS)

    Masui, Yasuhiro; Kawada, Koji; Katoh, Arata; Tsuji, Takashi; Suwabe, Mizue

    2004-02-01

    It is very important to estimate the facies distribution of heterogeneous sedimentary rocks for geological disposal of high level radioactive waste. The heterogeneousness of sedimentary rocks is due to variable distribution of grain size and mineral composition. The objective of this study is to establish the evaluation method for heterogeneous sedimentary rocks based on forward model. This study consisted of geological study for Horonobe area and the development of soft wear for sedimentary model. Geological study was composed of following items. 1. The sedimentary system for Koetoi and Wakkanai formations in Horonobe area was compiled based on papers. 2. The cores of HDB-1 were observed mainly from sedimentological view. 3. The facies and compaction property of argillaceous rocks were studied based on physical logs and core analysis data of wells. 4. The structure maps, isochrone maps, isopach maps and restored geological sections were made. The soft wear for sedimentary model to show sedimentary system on a basin scale was developed. This soft wear estimates the facies distribution and hydraulic conductivity of sedimentary rocks on three dimensions scale by numerical simulation. (author)

  2. A Preliminary Study on the Multiple Mapping Structure of Classification Systems for Heterogeneous Databases

    OpenAIRE

    Seok-Hyoung Lee; Hwan-Min Kim; Ho-Seop Choe

    2012-01-01

    While science and technology information service portals and heterogeneous databases produced in Korea and other countries are integrated, methods of connecting the unique classification systems applied to each database have been studied. Results of technologists' research, such as, journal articles, patent specifications, and research reports, are organically related to each other. In this case, if the most basic and meaningful classification systems are not connected, it is difficult to ach...

  3. The cardiac muscle duplex as a method to study myocardial heterogeneity

    Science.gov (United States)

    Solovyova, O.; Katsnelson, L.B.; Konovalov, P.V.; Kursanov, A.G.; Vikulova, N.A.; Kohl, P.; Markhasin, V.S.

    2014-01-01

    This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified. PMID:25106702

  4. Heterogeneous Fenton-like discoloration of methyl orange using Fe3O4/MWCNTs as catalyst: combination mechanism and affecting parameters

    Science.gov (United States)

    Xu, Huan-Yan; Wang, Yuan; Shi, Tian-Nuo; Zhao, Hang; Tan, Qu; Zhao, Bo-Chao; He, Xiu-Lan; Qi, Shu-Yan

    2018-03-01

    Multi-walled carbon nanotubes (MWCNTs) can act not only as a support for Fe3O4 nanoparticles (NPs) but also as a coworker with synergistic effect, accordingly improving the heterogeneous Fenton-like efficiency of Fe3O4 NPs. In this study, Fe3O4 NPs were in situ anchored onto MWCNTs by a moderate co-precipitation method and the as-prepared Fe3O4/MWCNTs nanocomposites were employed as the highly efficient Fenton-like catalysts. The analyses of XRD, FTIR, Raman, FESEM, TEM and HRTEM results indicated the formation of Fe3O4 crystals in Fe3O4/MWCNTs nanocomposites prepared at different conditions and the interaction between Fe3O4 NPs and MWCNTs. Over a wide pH range, the surface of modified MWCNTs possessed negative charges. Based on these results, the possible combination mechanism between Fe3O4 NPs and MWCNTs was discussed and proposed. Moreover, the effects of preparation and catalytic conditions on the Fenton-like catalytic efficiency were investigated in order to gain further insight into the heterogeneous Fenton-like reaction catalyzed by Fe3O4/MWCNTs nanocomposites.

  5. Heterogeneous Teacher Recruitment and Social Studies Didactics: Bringing the Sociology of Education Back In

    Directory of Open Access Journals (Sweden)

    AndreaSzukala

    2012-06-01

    Full Text Available This article contributes to a newer debate in teacher education research regarding the professionalization for the work in multicultural urban classrooms. In a social studies didactics’ perspective teacher-learnermismatch seems to be an important factor influencing the ability to construct meaningful social studies learning environments – and thus represents an important challenge for the education of future teachers in our domain. But what are the social origins of diverse teacher professional identities in the social studies domain? This article refers to a biographicalnarrative study on teacher students from very heterogeneous backgrounds exploring their basic beliefs and attitudes towards becoming a social studies teacher.

  6. Study of excitation energy dependence of nuclear level density parameter

    International Nuclear Information System (INIS)

    Mohanto, G.; Nayak, B.K.; Saxena, A.

    2016-01-01

    In the present study, we have populated CN by fusion reaction and excitation energy of the intermediate nuclei is determined after first chance α-emission to investigate excitation energy dependence of the NLD parameter. Evaporated neutron spectra were measured following alpha evaporation for obtaining NLD parameter for the reaction 11 B + 197 Au, populating CN 208 Po. This CN after evaporating an α-particle populates intermediate nucleus 204 Pb. The 204 Pb has magic number of Z=82. Our aim is to study the excitation energy dependence of NLD parameter for closed shell nuclei

  7. Spatial heterogeneity of metabolism in skeletal muscle in vivo studied by 31P-NMR spectroscopy

    International Nuclear Information System (INIS)

    Challiss, R.A.J.; Blackledge, M.J.; Radda, G.K.

    1988-01-01

    Phase modulated rotating-frame imaging, a localization technique for phosphorus nuclear magnetic resonance spectroscopy, has been applied to obtain information on heterogeneity of phosphorus-containing metabolites in skeletal muscle of the rat in vivo. The distal muscles of the rat hindlimb have been studied at rest and during steady-state isometric twitch contraction; the use of a transmitter surface coil and an electrically isolated, orthogonal receiver Helmholtz coil ensure accurate spatial assignment (1 mm resolution). At rest, intracellular pH was higher and PCr/(PCr + P i ) was lower in deeper muscle compared with superficial muscle of the distal hindlimb. Upon steady-state stimulation, the relatively more alkaline pH of deep muscle was maintained, whereas greater changes in PCr/(PCr + P i ) and P i /ATP occurred in the superficial muscle layer. This method allows rapid (75 min for each spectral image) acquisition of quantitative information on metabolic heterogeneity in vivo

  8. Systematic overview finds variation in approaches to investigating and reporting on sources of heterogeneity in systematic reviews of diagnostic studies

    NARCIS (Netherlands)

    Naaktgeboren, Christiana A.; van Enst, Wynanda A.; Ochodo, Eleanor A.; de Groot, Joris A. H.; Hooft, Lotty; Leeflang, Mariska M.; Bossuyt, Patrick M.; Moons, Karel G. M.; Reitsma, Johannes B.

    2014-01-01

    To examine how authors explore and report on sources of heterogeneity in systematic reviews of diagnostic accuracy studies. A cohort of systematic reviews of diagnostic tests was systematically identified. Data were extracted on whether an exploration of the sources of heterogeneity was undertaken,

  9. Validation of an experimental setup to study atmospheric heterogeneous ozonolysis of semi-volatile organic compounds

    Directory of Open Access Journals (Sweden)

    M. Pflieger

    2009-03-01

    Full Text Available There is currently a need for reliable experimental procedures to follow the heterogeneous processing simulating the atmospheric conditions. This work offers an alternative experimental device to study the behaviour of semi-volatile organic compounds (SVOC that presumably exhibit extremely slow reactivity (e.g. pesticides towards the atmospheric oxidants such as ozone and OH. Naphthalene was chosen as a test compound since it was widely studied in the past and hence represents a good reference. Prior to ozone exposure, the gaseous naphthalene was adsorbed via gas-solid equilibrium on silica and XAD-4 particles. Then, the heterogeneous reaction of ozone with adsorbed naphthalene was investigated in specially designed flow tube reactors. After the reaction, the remaining naphthalene (adsorbed on particles surface was extracted, filtered and analyzed by Gas Chromatography-Flame Ionization Detector (GC-FID. Thus, the kinetics results were obtained following the consumption of naphthalene. Using this procedure, the rate constants of heterogeneous ozonolysis of naphthalene (kO3 silica=2.26 (±0.09×10−17 cm3 molec−1 s−1 and kO3 XAD-4=4.29 (±1.06×10−19 cm3 molec−1 s−1 were determined for silica and XAD-4 particles, at 25°C and relative humidity <0.7%. The results show that the nature of the particles significantly affects the kinetics and that heterogeneous ozonolysis of naphthalene is faster than its homogeneous ozonolysis in the gas phase.

  10. Astrophysical parameters of ten poorly studied open star clusters

    International Nuclear Information System (INIS)

    Tadross, Ashraf Latif; El-Bendary, Reda; Osman, Anas; Ismail, Nader; Bakry, Abdel Aziz

    2012-01-01

    We present the fundamental parameters of ten open star clusters, nominated from Kronberger et al. who presented some newly discovered stellar groups on the basis of the Two Micron All Sky Survey photometry and Digitized Sky Survey visual images. Star counts and photometric parameters (radius, membership, distance, color excess, age, luminosity function, mass function, total mass, and dynamical relaxation time) have been determined for these ten clusters for the first time. In order to calibrate our procedures, the main parameters (distance, age, and color excess) have been re-estimated for another five clusters, which are also studied by Kronberger et al. (research papers)

  11. Study of the heterogeneity effects of lung in the evaluation of absorbed dose in radiotherapy

    International Nuclear Information System (INIS)

    Campos, Luciana Tourinho

    2006-02-01

    The main objective of radiotherapy is to deliver the highest possible dose to the tumour, in order to destroy it, reducing as much as possible the doses to healthy tissues adjacent to the target volume. Therefore, it is necessary to do a planning of the treatment. The more complex is the treatment, the more difficult the planning will be, demanding computation sophisticated methods in its execution, in order to consider the heterogeneities present in the human body. Additionally, with the appearing of new radiotherapeutic techniques, that used irradiation fields of small area, for instance, the intensity modulated radiotherapy, the difficulties for the execution of a reliable treatment planning, became still larger. In this work it was studied the influence of the lung heterogeneity in the planning of the curves of percentage depth dose, PDP, obtained with the Eclipse R planning system for different sizes of irradiation fields, using the correction algorithms for heterogeneities available in the planning system: modified Batho, general Batho and equivalent tissue-air ratio. A thorax phantom, manufactured in acrylic, containing a region made of cork to simulate the lung tissue, was used. The PDP curves generated by the planning system were compared to those obtained by Monte Carlo simulation and with the use of thermoluminescent, TL, dosimetry. It was verified that the algorithms used by the Eclipse R system for the correction of heterogeneity effects are not able to generate correct results for PDP curves in the case of small fields, occurring differences of up to 100%, when the 1x1 cm 2 treatment field is considered. These differences can cause a considerable subdosage in the lung tissue, reducing the possibility of the patient cure. (author)

  12. Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease.

    Directory of Open Access Journals (Sweden)

    Naoya Tanabe

    Full Text Available BACKGROUND: Cigarette smoke is the main risk factor for emphysema, which is a key pathology in chronic obstructive pulmonary disease (COPD. Low attenuation areas (LAA in computed tomography (CT images reflect emphysema, and the cumulative size distribution of LAA clusters follows a power law characterized by the exponent D. This property of LAA clusters can be explained by model simulation, where mechanical force breaks alveolar walls causing local heterogeneous lung tissue destruction. However, a longitudinal CT study has not investigated whether continuous smoking causes the spatially heterogeneous progression of emphysema. METHODS: We measured annual changes in ratios of LAA (LAA%, D and numbers of LAA clusters (LAN in CT images acquired at intervals of ≥ 3 years from 22 current and 31 former smokers with COPD to assess emphysema progression. We constructed model simulations using CT images to morphologically interpret changes in current smokers. RESULTS: D was decreased in current and former smokers, whereas LAA% and LAN were increased only in current smokers. The annual changes in LAA%, D, and LAN were greater in current, than in former smokers (1.03 vs. 0.37%, p=0.008; -0.045 vs. -0.01, p=0.004; 13.9 vs. 1.1, p=0.007, respectively. When LAA% increased in model simulations, the coalescence of neighboring LAA clusters decreased D, but the combination of changes in D and LAN in current smokers could not be explained by the homogeneous emphysema progression model despite cluster coalescence. Conversely, a model in which LAAs heterogeneously increased and LAA clusters merged somewhat in relatively advanced emphysematous regions could reflect actual changes. CONCLUSIONS: Susceptibility to parenchymal destruction induced by continuous smoking is not uniform over the lung, but might be higher in local regions of relatively advanced emphysema. These could result in the spatially heterogeneous progression of emphysema in current smokers.

  13. Meta-analysis, complexity, and heterogeneity: a qualitative interview study of researchers’ methodological values and practices

    Directory of Open Access Journals (Sweden)

    Theo Lorenc

    2016-11-01

    Full Text Available Abstract Background Complex or heterogeneous data pose challenges for systematic review and meta-analysis. In recent years, a number of new methods have been developed to meet these challenges. This qualitative interview study aimed to understand researchers’ understanding of complexity and heterogeneity and the factors which may influence the choices researchers make in synthesising complex data. Methods We conducted interviews with a purposive sample of researchers (N = 19 working in systematic review or meta-analysis across a range of disciplines. We analysed data thematically using a framework approach. Results Participants reported using a broader range of methods and data types in complex reviews than in traditional reviews. A range of techniques are used to explore heterogeneity, but there is some debate about their validity, particularly when applied post hoc. Conclusions Technical considerations of how to synthesise complex evidence cannot be isolated from questions of the goals and contexts of research. However, decisions about how to analyse data appear to be made in a largely informal way, drawing on tacit expertise, and their relation to these broader questions remains unclear.

  14. Impacts of heterogeneous reactions to atmospheric peroxides: Observations and budget analysis study

    Science.gov (United States)

    Qin, Mengru; Chen, Zhongming; Shen, Hengqing; Li, Huan; Wu, Huihui; Wang, Yin

    2018-06-01

    Atmospheric peroxides play important roles in atmospheric chemistry, acting as reactive oxidants and reservoirs of HOX and ROX radicals. Field measurements of atmospheric peroxides were conducted over urban Beijing from 2015 to 2016, including dust storm days, haze days and different seasons. We employed a box model based on RACM2 mechanism to conduct concentration simulation and budget analysis of hydrogen peroxide (H2O2) and peroxyacetic acid (PAA). In this study, heterogeneous reaction is found to be a significant sink for atmospheric H2O2 and PAA in urban Beijing. Here, we recommend a suitable uptake coefficient formula considering the water effect for model research of peroxides. It is found that H2O2 and PAA unexpectedly maintained considerable concentrations on haze days, even higher than that on non-haze days. This phenomenon is mainly ascribed to relatively high levels of volatile organic compounds and ozone on haze days. In addition, high levels of water vapor in pollution episode can promote not only the heterogeneous uptake to aerosol phase but also the production of H2O2. Atmospheric PAA formation is suggested to be sensitive to alkenes and NOX in urban Beijing. In particular, with the help of peroxides, sulfate formation rate from heterogeneous uptake could increase by ∼4 times on haze days, indicating the potential effect of peroxides on enhancement of aerosol oxidative property and secondary sulfate formation.

  15. Meta-analysis, complexity, and heterogeneity: a qualitative interview study of researchers' methodological values and practices.

    Science.gov (United States)

    Lorenc, Theo; Felix, Lambert; Petticrew, Mark; Melendez-Torres, G J; Thomas, James; Thomas, Sian; O'Mara-Eves, Alison; Richardson, Michelle

    2016-11-16

    Complex or heterogeneous data pose challenges for systematic review and meta-analysis. In recent years, a number of new methods have been developed to meet these challenges. This qualitative interview study aimed to understand researchers' understanding of complexity and heterogeneity and the factors which may influence the choices researchers make in synthesising complex data. We conducted interviews with a purposive sample of researchers (N = 19) working in systematic review or meta-analysis across a range of disciplines. We analysed data thematically using a framework approach. Participants reported using a broader range of methods and data types in complex reviews than in traditional reviews. A range of techniques are used to explore heterogeneity, but there is some debate about their validity, particularly when applied post hoc. Technical considerations of how to synthesise complex evidence cannot be isolated from questions of the goals and contexts of research. However, decisions about how to analyse data appear to be made in a largely informal way, drawing on tacit expertise, and their relation to these broader questions remains unclear.

  16. Delivery parameters, neonatal parameters and incidence of urinary incontinence six months postpartum: a cohort study.

    Science.gov (United States)

    Wesnes, Stian Langeland; Hannestad, Yngvild; Rortveit, Guri

    2017-10-01

    Contradictory results have been reported regarding most delivery parameters as risk factors for urinary incontinence. We investigated the association between the incidence of urinary incontinence six months postpartum and single obstetric risk factors as well as combinations of risk factors. This study was based on the Norwegian Mother and Child Cohort Study, conducted by the Norwegian Institute of Public Health during 1998-2008. This substudy was based on 7561 primiparous women who were continent before and during pregnancy. Data were obtained from questionnaires answered at weeks 15 and 30 of pregnancy and six months postpartum. Data were linked to the Medical Birth Registry of Norway. Single and combined delivery- and neonatal parameters were analyzed by logistic regression analyses. Birthweight was associated with significantly higher risk of urinary incontinence six months postpartum [3541-4180 g: odds ratio (OR) 1.4, 95% confidence interval (CI) 1.2-1.6; >4180 g: OR 1.6, 95% CI 1.2-2.0]. Fetal presentation, obstetric anal sphincter injuries, episiotomy and epidural analgesia were not significantly associated with increased risk of urinary incontinence. The following combinations of risk factors among women delivering by spontaneous vaginal delivery increased the risk of urinary incontinence six months postpartum; birthweight ≥3540 g and ≥36 cm head circumference; birthweight ≥3540 g and forceps, birthweight ≥3540 g and episiotomy; and ≥36 cm head circumference and episiotomy. Some combinations of delivery parameters and neonatal parameters seem to act together and may increase the risk of incidence of urinary incontinence six months postpartum in a synergetic way. © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.

  17. Spillover effects in epidemiology: parameters, study designs and methodological considerations

    Science.gov (United States)

    Benjamin-Chung, Jade; Arnold, Benjamin F; Berger, David; Luby, Stephen P; Miguel, Edward; Colford Jr, John M; Hubbard, Alan E

    2018-01-01

    Abstract Many public health interventions provide benefits that extend beyond their direct recipients and impact people in close physical or social proximity who did not directly receive the intervention themselves. A classic example of this phenomenon is the herd protection provided by many vaccines. If these ‘spillover effects’ (i.e. ‘herd effects’) are present in the same direction as the effects on the intended recipients, studies that only estimate direct effects on recipients will likely underestimate the full public health benefits of the intervention. Causal inference assumptions for spillover parameters have been articulated in the vaccine literature, but many studies measuring spillovers of other types of public health interventions have not drawn upon that literature. In conjunction with a systematic review we conducted of spillovers of public health interventions delivered in low- and middle-income countries, we classified the most widely used spillover parameters reported in the empirical literature into a standard notation. General classes of spillover parameters include: cluster-level spillovers; spillovers conditional on treatment or outcome density, distance or the number of treated social network links; and vaccine efficacy parameters related to spillovers. We draw on high quality empirical examples to illustrate each of these parameters. We describe study designs to estimate spillovers and assumptions required to make causal inferences about spillovers. We aim to advance and encourage methods for spillover estimation and reporting by standardizing spillover parameter nomenclature and articulating the causal inference assumptions required to estimate spillovers. PMID:29106568

  18. Reactor parameters for European economic, safety and environmental studies

    International Nuclear Information System (INIS)

    Hancox, R.; Cooke, P.I.H.; Spears, W.R.

    1990-01-01

    Parameter sets for five 1200 MW e tokamak reactors were developed for the European Study Group on the Environmental, Safety-related and Economic Potential of Fusion Power, showing today's perception of the range of reactors likely to be available as a result of the Commission's fusion programme. On the basis of the cost of generating electricity, relative to a fission reactor, a reference set was chosen and endorsed by the Group for further studies including that on the environmental impact of fusion power. Key physics and technology parameters for the reference reactor are compared with values used in the ITER design, and with those from American studies. (author)

  19. Study on the Energetic Parameters in a Photothermic Sensor with ...

    African Journals Online (AJOL)

    Study on the Energetic Parameters in a Photothermic Sensor with Black Polymeric Film. ... The evolution of incidental solar illumination on the horizontal plan of sensor and the temperature distribution are studied. Results showed that the ... Keywords: film, solar energy, greenhouse effect, design, radiation, illumination.

  20. A numerical study of non-linear crack tip parameters

    Directory of Open Access Journals (Sweden)

    F.V. Antunes

    2015-07-01

    Full Text Available Crack closure concept has been widely used to explain different issues of fatigue crack propagation. However, different authors have questioned the relevance of crack closure and have proposed alternative concepts. The main objective here is to check the effectiveness of crack closure concept by linking the contact of crack flanks with non-linear crack tip parameters. Accordingly, 3D-FE numerical models with and without contact were developed for a wide range of loading scenarios and the crack tip parameters usually linked to fatigue crack growth, namely range of cyclic plastic strain, crack tip opening displacement, size of reversed plastic zone and total plastic dissipation per cycle, were investigated. It was demonstrated that: i LEFM concepts are applicable to the problem under study; ii the crack closure phenomenon has a great influence on crack tip parameters decreasing their values; iii the Keff concept is able to explain the variations of crack tip parameters produced by the contact of crack flanks; iv the analysis of remote compliance is the best numerical parameter to quantify the crack opening level; v without contact there is no effect of stress ratio on crack tip parameters. Therefore it is proved that the crack closure concept is valid.

  1. Evolution and development of model membranes for physicochemical and functional studies of the membrane lateral heterogeneity.

    Science.gov (United States)

    Morigaki, Kenichi; Tanimoto, Yasushi

    2018-03-14

    One of the main questions in the membrane biology is the functional roles of membrane heterogeneity and molecular localization. Although segregation and local enrichment of protein/lipid components (rafts) have been extensively studied, the presence and functions of such membrane domains still remain elusive. Along with biochemical, cell observation, and simulation studies, model membranes are emerging as an important tool for understanding the biological membrane, providing quantitative information on the physicochemical properties of membrane proteins and lipids. Segregation of fluid lipid bilayer into liquid-ordered (Lo) and liquid-disordered (Ld) phases has been studied as a simplified model of raft in model membranes, including giant unilamellar vesicles (GUVs), giant plasma membrane vesicles (GPMVs), and supported lipid bilayers (SLB). Partition coefficients of membrane proteins between Lo and Ld phases were measured to gauze their affinities to lipid rafts (raftophilicity). One important development in model membrane is patterned SLB based on the microfabrication technology. Patterned Lo/Ld phases have been applied to study the partition and function of membrane-bound molecules. Quantitative information of individual molecular species attained by model membranes is critical for elucidating the molecular functions in the complex web of molecular interactions. The present review gives a short account of the model membranes developed for studying the lateral heterogeneity, especially focusing on patterned model membranes on solid substrates. Copyright © 2018 Elsevier B.V. All rights reserved.

  2. Experimental study of an isochorically heated heterogeneous interface. A progress report

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Juan Carlos [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-08-20

    Outline of the presentation: Studying possible mix / interface motion between heterogeneous low/high Z interfaces driven by 2-fluid or kinetic plasma effects (Heated to few eV, Sharp (sub µm) interface); Isochoric heating to initialize interface done with Al quasimonoenergetic ion beams on Trident; Have measured isochoric heating in individual materials intended for compound targets; Fielded experiments on Trident to measure interface motion (Gold-diamond, tin-aluminium); Measured heated-sample temperature with streaked optical pyrometry (SOP) (UT Austin led (research contract), SOP tests → heating uniformity Vs thickness on Al foils. Results are being analyzed.

  3. Experimental studies of 350 Mw(e) heterogeneous LMFBR cores at ZPPR

    International Nuclear Information System (INIS)

    Collins, P.J.; McFarlane, H.F.; Beck, C.L.; Lineberry, M.J.; Carpenter, S.G.; Ducat, G.A.; Gasidlo, J.M.; Goin, R.W.

    1979-01-01

    The annular heterogeneous concept has been adopted for the Clinch River Breeder Reactor. To provide verification of design and safety analysis, fourteen core configurations were studied at ZPPR. The results and analysis of the early assemblies, ZPPR-7A, 7B, and 7C, have been previously reported and only the more significant conclusions are summarized here. Later assemblies, 7D to 7H, were designed to provide data on variations of control rod and internal blanket arrangements. Assemblies 8A to 8E provided data on the replacement of uranium by thorium in various blanket subassemblies

  4. PRELIMINARY STUDY OF HEMATOLOGICAL PARAMETERS IN HERZEGOVINIAN DONKEY

    Directory of Open Access Journals (Sweden)

    Dunja Rukavina

    2016-02-01

    Full Text Available Herzegovinian donkey is a very important animal resource of Bosnia and Herzegovina. There have been no works attempted at determining the normal values of hematological parameters of Herzegovinian donkey. For this reason, the objective of the present study was to investigate some hematological parameters in Herzegovinian donkey. The research was performed on 30 apparently healthy donkeys (18 female and 12 male of ages from 1 to 20 years. Blood samples (3 ml were obtained by jugular vein puncture (vena jugularis externa in vacuum tubes with EDTA. The mean value of hematocrit was 29.19 %, hemoglobin concentration 10.6 g/dl, mean corpuscular hemoglobin concentration 36.33 g/dl, white blood cells 9.33 x109/L, granulocytes (109/L 5.45 x109/L, granulocytes (% 59.47%, lymphocyte/monocyte (109/L 3.89 x109/L, lymphocyte/monocyte (% 40.53% and platelet cells 148.97 x109/L. Parameters were determined using an automated analyzer IDEXX QBC VET AutoRead. Data were analyzed by SPSS V 15. All hematological parameters (except platelet cells were consistent with the recommended reference ranges for donkeys, and the values found in literature so far. Platelet cells values were much lower than in the literature for the other donkey breeds and the recommended reference ranges for donkeys. The slight differences found between our results and those reported in the previous works confirm the need for further studies to investigate the reference values of hematological parameters of Herzegovinian donkey. This work is a contribution to the study of hematological parameters of Herzegovinian donkey, and we expect these data to be applied to the further studies.

  5. HUMAN CAPITAL HETEROGENEITY AND ORGANIZATIONAL PERFORMANCE ANALYSIS: AN EMPIRICAL STUDY ABOUT INTERNATIONAL HOTEL CHAINS IN TURKEY

    Directory of Open Access Journals (Sweden)

    Ali Halici

    2012-01-01

    Full Text Available Today, workforce diversity is not only a legal requirement for organizations, but it is also a must to survive in a highly competitive business environment. The prime motive for this study is to investigate the relationship between workforce diversity and perception of discrimination. The basic hypothesis of the study is that as the workforce diversity increases, the perception of discrimination decreases. In order to test the hypothesis, a survey is carried out international hotel chains in Istanbul. There are 19 international hotel chains in Turkey. In this study research is designed to understand human capital heterogeneity pattern of international chains of hotel industry and how this contribute organizational culture strategically that help to manage organizational performance much more efficiently with cross sectional data. Globalization of markets, changing demographics in the labor market, new business strategies requiring team work and the shift from a manufacturing to a service economy are the prime reasons for human capital heterogeneity (HCH. HCH improves the organizational capabilities in terms of flexibility, creativity, problem solving and competitive advantage. Especially in the service sector, in order to gain competitive advantage, organizations need a diverse workforce for both understanding the diverse needs of customers and answering to these needs in a prompt and proper way.

  6. The normative study of acoustic parameters in normal Egyptian ...

    African Journals Online (AJOL)

    Yehia A. Abo-Ras

    2013-03-21

    Mar 21, 2013 ... all children were subjected to computerized acoustic analysis using Multidimensional voice program ... cal quality is important for social relations to happen effectively. ... lish comparative parameters with the normal values of the acoustic ... from lower age ranges in the normative studies since the child's.

  7. Developing the Parameters of Scholarship in Postgraduate Coursework Studies

    Science.gov (United States)

    McLay, Allan F.

    2013-01-01

    Scholarship parameters, in relation to postgraduate coursework studies, are developed against the expectations of the Boyer classifications of scholarship (Boyer, 1990) with particular emphasis on the role of minor thesis development. An example is presented in which postgraduate coursework students are required to undertake a three semester minor…

  8. Parameters of importance to determine in geoscientific site studies

    International Nuclear Information System (INIS)

    Andersson, Johan; Almen, K.E.; Ericsson, L.O.; Karlsson, Fred; Stroem, A.; Fredriksson, Anders; Stanfors, R.

    1996-12-01

    This report identifies and describes parameters, that may be determined in a site characterization study, for performing functional and safety analyses of a deep rock repository for radioactive wastes. The report discusses data needs for rock engineering and for description of other environmental aspects. It is intended that the report be used as a basis for formulating the criteria of acceptance in evaluating a candidate site. The report describes how different parameters influence the safety function, and how they are evaluated in practice. The logical order of performing measurements, due to the need of in-data and influence on other measurements is also discussed. 65 refs

  9. Estimates of Between-Study Heterogeneity for 705 Meta-Analyses Reported in Psychological Bulletin From 1990–2013

    Directory of Open Access Journals (Sweden)

    Sara van Erp

    2017-08-01

    Full Text Available We present a data set containing 705 between-study heterogeneity estimates τ2 as reported in 61 articles published in 'Psychological Bulletin' from 1990–2013. The data set also includes information about the number and type of effect sizes, the 'Q'- and 'I'2-statistics, and publication bias. The data set is stored in the Open Science Framework repository (https://osf.io/wyhve/ and can be used for several purposes: (1 to compare a specific heterogeneity estimate to the distribution of between-study heterogeneity estimates in psychology; (2 to construct an informed prior distribution for the between-study heterogeneity in psychology; (3 to obtain realistic population values for Monte Carlo simulations investigating the performance of meta-analytic methods.   Funding statement: This research was supported by the ERC project “Bayes or Bust”.

  10. Image Segmentation Parameter Optimization Considering Within- and Between-Segment Heterogeneity at Multiple Scale Levels: Test Case for Mapping Residential Areas Using Landsat Imagery

    Directory of Open Access Journals (Sweden)

    Brian A. Johnson

    2015-10-01

    Full Text Available Multi-scale/multi-level geographic object-based image analysis (MS-GEOBIA methods are becoming widely-used in remote sensing because single-scale/single-level (SS-GEOBIA methods are often unable to obtain an accurate segmentation and classification of all land use/land cover (LULC types in an image. However, there have been few comparisons between SS-GEOBIA and MS-GEOBIA approaches for the purpose of mapping a specific LULC type, so it is not well understood which is more appropriate for this task. In addition, there are few methods for automating the selection of segmentation parameters for MS-GEOBIA, while manual selection (i.e., trial-and-error approach of parameters can be quite challenging and time-consuming. In this study, we examined SS-GEOBIA and MS-GEOBIA approaches for extracting residential areas in Landsat 8 imagery, and compared naïve and parameter-optimized segmentation approaches to assess whether unsupervised segmentation parameter optimization (USPO could improve the extraction of residential areas. Our main findings were: (i the MS-GEOBIA approaches achieved higher classification accuracies than the SS-GEOBIA approach, and (ii USPO resulted in more accurate MS-GEOBIA classification results while reducing the number of segmentation levels and classification variables considerably.

  11. Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.

    Directory of Open Access Journals (Sweden)

    Štefan Holiga

    Full Text Available To tackle the heterogeneity of Parkinson's disease symptoms, most functional imaging studies tend to select a uniform group of subjects. We hypothesize that more profound considerations are needed to account for intra/inter-subject clinical variability and possibly for differing pathophysiological processes. Twelve patients were investigated using functional magnetic resonance imaging during visually-guided finger tapping. To account for disease heterogeneity, the motor score and individual symptom scores from the Unified Parkinson's Disease Rating Scale (UPDRS-III were utilized in the group-level model using two approaches either as the explanatory variable or as the effect of interest. Employment of the UPDRS-III score and symptom scores was systematically tested on the resulting group response to the levodopa challenge, which further accentuated the diversity of the diseased state of participants. Statistics revealed a bilateral group response to levodopa in the basal ganglia. Interestingly, systematic incorporation of individual motor aspects of the disease in the modelling amended the resulting activity patterns conspicuously, evidencing a manifold amount of explained variability by the particular score. In conclusion, the severity of clinical symptoms expressed in the UPDRS-III scores should be considered in the analysis to attain unbiased statistics, draw reliable conclusions and allow for comparisons between research groups studying Parkinson's disease using functional magnetic resonance imaging.

  12. Application of phasor plot and autofluorescence correction for study of heterogeneous cell population

    Science.gov (United States)

    Szmacinski, Henryk; Toshchakov, Vladimir; Lakowicz, Joseph R.

    2014-01-01

    Abstract. Protein-protein interactions in cells are often studied using fluorescence resonance energy transfer (FRET) phenomenon by fluorescence lifetime imaging microscopy (FLIM). Here, we demonstrate approaches to the quantitative analysis of FRET in cell population in a case complicated by a highly heterogeneous donor expression, multiexponential donor lifetime, large contribution of cell autofluorescence, and significant presence of unquenched donor molecules that do not interact with the acceptor due to low affinity of donor-acceptor binding. We applied a multifrequency phasor plot to visualize FRET FLIM data, developed a method for lifetime background correction, and performed a detailed time-resolved analysis using a biexponential model. These approaches were applied to study the interaction between the Toll Interleukin-1 receptor (TIR) domain of Toll-like receptor 4 (TLR4) and the decoy peptide 4BB. TLR4 was fused to Cerulean fluorescent protein (Cer) and 4BB peptide was labeled with Bodipy TMRX (BTX). Phasor displays for multifrequency FLIM data are presented. The analytical procedure for lifetime background correction is described and the effect of correction on FLIM data is demonstrated. The absolute FRET efficiency was determined based on the phasor plot display and multifrequency FLIM data analysis. The binding affinity between TLR4-Cer (donor) and decoy peptide 4BB-BTX (acceptor) was estimated in a heterogeneous HeLa cell population. PMID:24770662

  13. Study of dosimetric effects due to metallic heterogeneity of tissue expanders in post-mastectomy radiotherapy

    International Nuclear Information System (INIS)

    Trombetta, Debora M.; Silva, Ademir X. da; Rosa, Luiz A.R. da

    2009-01-01

    Breast cancer is the most common cancer among women. In each year approximately 20% of the new cases of cancer in women are breast cancers. Despite the increase in the use of breast-conserving treatment, some women still require mastectomy as their primary surgical management. A large part of these women, whom undergo a mastectomy, realize a breast reconstruction afterwards. The most common options for reconstruction include autogenous tissue techniques and tissue expansion followed by breast implant placement. Many trials have demonstrated a survival benefit associated with post-mastectomy radiotherapy mainly if the treatment starts right after the mastectomy. In such case patients whom were realizing the breast reconstruction using tissue expanders can be irradiated using this. These patients posses a material with high atomic number within the irradiated area, so this metallic port becomes an heterogeneity which can modify the calculated doses distribution for the treatment. The study was due through the quantification of the relative transmission of 6MV and 15MV radiotherapy beam, making use of computer simulations with Monte Carlo method implemented by the MCNPX code. The results show that the presence of this metallic heterogeneity changes the transmission of the beam, causing a reduction up to 13% in the geometric shadowed region. According to dosimetric protocols, which recommend that the reduction in the dose should be bellow of 5%, the difference found in the study could be significant. (author)

  14. Reassessment of HIV-1 acute phase infectivity: accounting for heterogeneity and study design with simulated cohorts.

    Directory of Open Access Journals (Sweden)

    Steve E Bellan

    2015-03-01

    Full Text Available The infectivity of the HIV-1 acute phase has been directly measured only once, from a retrospectively identified cohort of serodiscordant heterosexual couples in Rakai, Uganda. Analyses of this cohort underlie the widespread view that the acute phase is highly infectious, even more so than would be predicted from its elevated viral load, and that transmission occurring shortly after infection may therefore compromise interventions that rely on diagnosis and treatment, such as antiretroviral treatment as prevention (TasP. Here, we re-estimate the duration and relative infectivity of the acute phase, while accounting for several possible sources of bias in published estimates, including the retrospective cohort exclusion criteria and unmeasured heterogeneity in risk.We estimated acute phase infectivity using two approaches. First, we combined viral load trajectories and viral load-infectivity relationships to estimate infectivity trajectories over the course of infection, under the assumption that elevated acute phase infectivity is caused by elevated viral load alone. Second, we estimated the relative hazard of transmission during the acute phase versus the chronic phase (RHacute and the acute phase duration (dacute by fitting a couples transmission model to the Rakai retrospective cohort using approximate Bayesian computation. Our model fit the data well and accounted for characteristics overlooked by previous analyses, including individual heterogeneity in infectiousness and susceptibility and the retrospective cohort's exclusion of couples that were recorded as serodiscordant only once before being censored by loss to follow-up, couple dissolution, or study termination. Finally, we replicated two highly cited analyses of the Rakai data on simulated data to identify biases underlying the discrepancies between previous estimates and our own. From the Rakai data, we estimated RHacute = 5.3 (95% credibility interval [95% CrI]: 0.79-57 and dacute

  15. Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts

    Science.gov (United States)

    Bellan, Steve E.; Dushoff, Jonathan; Galvani, Alison P.; Meyers, Lauren Ancel

    2015-01-01

    Background The infectivity of the HIV-1 acute phase has been directly measured only once, from a retrospectively identified cohort of serodiscordant heterosexual couples in Rakai, Uganda. Analyses of this cohort underlie the widespread view that the acute phase is highly infectious, even more so than would be predicted from its elevated viral load, and that transmission occurring shortly after infection may therefore compromise interventions that rely on diagnosis and treatment, such as antiretroviral treatment as prevention (TasP). Here, we re-estimate the duration and relative infectivity of the acute phase, while accounting for several possible sources of bias in published estimates, including the retrospective cohort exclusion criteria and unmeasured heterogeneity in risk. Methods and Findings We estimated acute phase infectivity using two approaches. First, we combined viral load trajectories and viral load-infectivity relationships to estimate infectivity trajectories over the course of infection, under the assumption that elevated acute phase infectivity is caused by elevated viral load alone. Second, we estimated the relative hazard of transmission during the acute phase versus the chronic phase (RHacute) and the acute phase duration (d acute) by fitting a couples transmission model to the Rakai retrospective cohort using approximate Bayesian computation. Our model fit the data well and accounted for characteristics overlooked by previous analyses, including individual heterogeneity in infectiousness and susceptibility and the retrospective cohort's exclusion of couples that were recorded as serodiscordant only once before being censored by loss to follow-up, couple dissolution, or study termination. Finally, we replicated two highly cited analyses of the Rakai data on simulated data to identify biases underlying the discrepancies between previous estimates and our own. From the Rakai data, we estimated RHacute = 5.3 (95% credibility interval [95% CrI]: 0

  16. Monte Carlo parameter studies and uncertainty analyses with MCNP5

    International Nuclear Information System (INIS)

    Brown, F. B.; Sweezy, J. E.; Hayes, R.

    2004-01-01

    A software tool called mcnp p study has been developed to automate the setup, execution, and collection of results from a series of MCNP5 Monte Carlo calculations. This tool provides a convenient means of performing parameter studies, total uncertainty analyses, parallel job execution on clusters, stochastic geometry modeling, and other types of calculations where a series of MCNP5 jobs must be performed with varying problem input specifications. (authors)

  17. Study of pipe-whip parameters in pipelines

    International Nuclear Information System (INIS)

    Guerreiro, J.N.C.; Loula, A.F.D.; Galeao, A.C.N.R.

    1980-01-01

    The problem of the high energy pipe-whip, assuming an elastic-plastic behavior for the tube material and taking in account the internal pressure, is studied. The constraints are simulated as bilinear springs and viscous dampers. A general research, based on the finite element method was developed to analyse the phenomenon. The influence of the following parameters: gap, damping coefficient, stiffness, constraints positioning and internal pressure of the tube is studied. (Author) [pt

  18. Blocking effect and numerical study of polymer particles dispersion flooding in heterogeneous reservoir

    Science.gov (United States)

    Zhu, Weiyao; Li, Jianhui; Lou, Yu

    2018-02-01

    Polymer flooding has become an effective way to improve the sweep efficiency in many oil fields. Many scholars have carried out a lot of researches on the mechanism of polymer flooding. In this paper, the effect of polymer on seepage is analyzed. The blocking effect of polymer particles was studied experimentally, and the residual resistance coefficient (RRF) were used to represent the blocking effect. We also build a mathematical model for heterogeneous concentration distribution of polymer particles. Furthermore, the effects of polymer particles on reservoir permeability, fluid viscosity and relative permeability are considered, and a two-phase flow model of oil and polymer particles is established. In addition, the model was tested in the heterogeneous stratum model, and three influencing factors, such as particle concentration, injection volume and PPD (short for polymer particle dispersion) injection time, were analyzed. Simulation results show that PPD can effectively improve sweep efficiency and especially improve oil recovery of low permeability layer. Oil recovery increases with the increase of particle concentration, but oil recovery increase rate gradually decreases with that. The greater the injected amount of PPD, the greater oil recovery and the smaller oil recovery increase rate. And there is an optimal timing to inject PPD for specific reservoir.

  19. Exploiting heterogeneous publicly available data sources for drug safety surveillance: computational framework and case studies.

    Science.gov (United States)

    Koutkias, Vassilis G; Lillo-Le Louët, Agnès; Jaulent, Marie-Christine

    2017-02-01

    Driven by the need of pharmacovigilance centres and companies to routinely collect and review all available data about adverse drug reactions (ADRs) and adverse events of interest, we introduce and validate a computational framework exploiting dominant as well as emerging publicly available data sources for drug safety surveillance. Our approach relies on appropriate query formulation for data acquisition and subsequent filtering, transformation and joint visualization of the obtained data. We acquired data from the FDA Adverse Event Reporting System (FAERS), PubMed and Twitter. In order to assess the validity and the robustness of the approach, we elaborated on two important case studies, namely, clozapine-induced cardiomyopathy/myocarditis versus haloperidol-induced cardiomyopathy/myocarditis, and apixaban-induced cerebral hemorrhage. The analysis of the obtained data provided interesting insights (identification of potential patient and health-care professional experiences regarding ADRs in Twitter, information/arguments against an ADR existence across all sources), while illustrating the benefits (complementing data from multiple sources to strengthen/confirm evidence) and the underlying challenges (selecting search terms, data presentation) of exploiting heterogeneous information sources, thereby advocating the need for the proposed framework. This work contributes in establishing a continuous learning system for drug safety surveillance by exploiting heterogeneous publicly available data sources via appropriate support tools.

  20. The study of the price of gold futures based on heterogeneous investors' overconfidence

    Institute of Scientific and Technical Information of China (English)

    Wei Jiang; Pupu Luan; Chunpeng Yang

    2014-01-01

    Purpose-The purpose of this paper is to research and analyze the price of gold futures based on heterogeneous investors' overconfidence.Design/methodology/approach-This paper divides the traders of gold futures market into two kinds:the speculators and arbitrageurs,and then constructs a market equilibrium model of futures pricing to analyze the behaviors of the two kinds of traders with overconfidence.After getting the decision-making function,the market equilibrium futures price is attained on the condition of market clearing.Then,this paper analyzes how the overconfidence impacts on futures price,volatility of the price of gold futures and the effects on individual utility.Findings-Under different market conditions,the overconfidence psychological impacts of heterogeneous investor on the price and volatility of futures are different,sometimes completely opposite.Originality/value-In the past literature,the relationships between overconfidence and the price or volatility are positive;however,the study shows that sometimes it is positive,and sometimes it is negative

  1. Numerical study for Darcy-Forchheimer flow due to a curved stretching surface with Cattaneo-Christov heat flux and homogeneous-heterogeneous reactions

    Directory of Open Access Journals (Sweden)

    Tasawar Hayat

    Full Text Available The current investigation presents Darcy-Forchheimer flow of viscous fluid caused by a curved stretching sheet. Flow for porous space is characterized by Darcy-Forchheimer relation. Concept of homogeneous and heterogeneous reactions is also utilized. Heat transfer for Cattaneo–Christov theory characterizing the feature of thermal relaxation is incorporated. Nonlinear differential systems are derived. Shooting algorithm is employed to construct the solutions for the resulting nonlinear system. The characteristics of various sundry parameters are studied and discussed. Skin friction coefficient and heat transfer rate are numerically described. Keywords: 2D flow, Curved stretching surface, Darcy-Forchheimer porous medium, Cattaneo-Christov heat flux, Homogeneous-heterogeneous reactions

  2. Study of the interaction of protons with heterogeneous targets; Estudo da interacao de protons com alvos heterogeneos

    Energy Technology Data Exchange (ETDEWEB)

    Negrao, Roberta Rocha; Hormaza, Joel Mesa, E-mail: beta_rocha@aluno.ibb.unesp.br [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu-SP (Brazil)

    2016-07-01

    The passage of proton beams through heterogeneous targets was studied in the energy range 230-270 MeV using the software based on Monte Carlo method SRIM 2013. The targets were simulated in line-pair format, composed of water with inserted heterogeneities materials of inflated lung and compact bone in their respective phantoms 25cm. We assessed the distribution functions of the position and the beams output energy in 12 different settings of target-energy. (author)

  3. Study on uncertainty evaluation methodology related to hydrological parameter of regional groundwater flow analysis model

    International Nuclear Information System (INIS)

    Sakai, Ryutaro; Munakata, Masahiro; Ohoka, Masao; Kameya, Hiroshi

    2009-11-01

    In the safety assessment for a geological disposal of radioactive waste, it is important to develop a methodology for long-term estimation of regional groundwater flow from data acquisition to numerical analyses. In the uncertainties associated with estimation of regional groundwater flow, there are the one that concerns parameters and the one that concerns the hydrologeological evolution. The uncertainties of parameters include measurement errors and their heterogeneity. The authors discussed the uncertainties of hydraulic conductivity as a significant parameter for regional groundwater flow analysis. This study suggests that hydraulic conductivities of rock mass are controlled by rock characteristics such as fractures, porosity and test conditions such as hydraulic gradient, water quality, water temperature and that there exists variations more than ten times in hydraulic conductivity by difference due to test conditions such as hydraulic gradient or due to rock type variations such as rock fractures, porosity. In addition this study demonstrated that confining pressure change caused by uplift and subsidence and change of hydraulic gradient under the long-term evolution of hydrogeological environment could possibly produce variations more than ten times of magnitude in hydraulic conductivity. It was also shown that the effect of water quality change on hydraulic conductivity was not negligible and that the replacement of fresh water and saline water caused by sea level change could induce 0.6 times in current hydraulic conductivities in case of Horonobe site. (author)

  4. Magnetism in heterogeneous thin film systems: Resonant X-ray scattering studies

    International Nuclear Information System (INIS)

    Kortright, J.B.; Jiang, J.S.; Bader, S.D.; Hellwig, O.; Marguiles, D.T.; Fullerton, E.E.

    2002-01-01

    Magnetic and chemical heterogeneity are common in a broad range of magnetic thin film systems. Emerging resonant soft x-ray scattering techniques are well suited to resolve such heterogeneity at relevant length scales. Resonant x-ray magneto-optical Kerr effect measurements laterally average over heterogeneity but can provide depth resolution in different ways, as illustrated in measurements resolving reversible and irreversible changes in different layers of exchange-spring heterostructures. Resonant small-angle scattering measures in-plane heterogeneity and can resolve magnetic and chemical scattering sources in different ways, as illustrated in measurements of granular alloy recording media

  5. Parameter studies for a two-component fusion experiment

    International Nuclear Information System (INIS)

    Towner, H.H.

    1975-01-01

    The sensitivity of the energy multiplication of a two-component fusion experiment is examined relative to the following parameters: energy confinement time (tau/sub E/), particle confinement time (tau/sub p/), effective Z of the plasma (Z/sub eff/), injection rate (j/sub I/) and injection energy (E/sub I/). The Energy Research and Development Administration recently approved funding for such a fusion device (the Toroidal Fusion Test Reactor or TFTR) which will be built at the Princeton Plasma Physics Laboratory. Hence, such a parameter study seems both timely and necessary. This work also serves as an independent check on the design values proposed for the TFTR to enable it to achieve energy breakeven (F = 1). Using the nominal TFTR design parameters and a self-consistent ion-electron power balance, the maximum F-value is found to be approximately 1.2 which occurs at an injection energy of approximately 210 KeV. The injector operation, i.e. its current and energy capability are shown to be a very critical factor in the TFTR performance. However, if the injectors meet the design objectives, there appears to be sufficient latitude in the other parameters to offer reasonable assurance that energy breakeven can be achieved. (U.S.)

  6. Studies of Heterogenous Palladium and Related Catalysts for Aerobic Oxidation of Primary Alcohols

    Science.gov (United States)

    Ahmed, Maaz S.

    alcohol solvent and the surface of the catalyst: (listed in order of strength) lone pair-surface (heterocyclic primary alcohols) > pi-surface (aryl primary alcohols) > van der Waals-surface (alkyl primary alcohols). These interactions were previously underappreciated in condensed phase heterogeneously catalyzed aerobic oxidations. Bi and Te serve as synergistic promoters that enhance both the rate and yield of the reactions relative to reactions employing Pd alone or Pd in combination with Bi or with Te as the sole promoter. We report X-ray absorption spectroscopic studies of the heterogenous catalyst. These methods show that the promoters undergo oxidation in preference to Pd, maintaining the Pd surface in the active metallic state and preventing inhibition by surface Pd-oxide formation. The data also suggest formation of a Pd-Te alloy phase that modifies the electronic properties of the Pd catalyst. Collectively, these results provide valuable insights into the synergistic benefits of multiple promoters in heterogeneous catalytic oxidation reactions.

  7. Nuclear Criticality Technology and Safety Project parameter study database

    International Nuclear Information System (INIS)

    Toffer, H.; Erickson, D.G.; Samuel, T.J.; Pearson, J.S.

    1993-03-01

    A computerized, knowledge-screened, comprehensive database of the nuclear criticality safety documentation has been assembled as part of the Nuclear Criticality Technology and Safety (NCTS) Project. The database is focused on nuclear criticality parameter studies. The database has been computerized using dBASE III Plus and can be used on a personal computer or a workstation. More than 1300 documents have been reviewed by nuclear criticality specialists over the last 5 years to produce over 800 database entries. Nuclear criticality specialists will be able to access the database and retrieve information about topical parameter studies, authors, and chronology. The database places the accumulated knowledge in the nuclear criticality area over the last 50 years at the fingertips of a criticality analyst

  8. Geotechnical parameters for three deep ocean study areas

    International Nuclear Information System (INIS)

    Nicholson, D.P.

    1989-01-01

    This chapter summarizes the results of geotechnical measurements made on cores taken at the three deep ocean sites that have been studied in detail as part of the international programme assessing the feasibility of deep ocean disposal of heat-generating radioactive waste. The capabilities of existing sampling methods and the adequacy of the available data for providing the geotechnical parameters needed to evaluate the technical feasibility of deep ocean disposal are discussed. It is concluded that, while it has not been possible to obtain core samples of sufficient quality and depth to provide all the parameters needed for the assessment, no fundamental differences between the sediments at the study areas and those found on land or in shallow water have been identified. (author)

  9. Social support among heterogeneous partners : an experimental test

    NARCIS (Netherlands)

    Vogt, Sonja; Weesie, Jeroen

    2006-01-01

    This paper studies how dyadic social support is affected by heterogeneity of the partners.We distinguish heterogeneity with respect to three parameters: the likelihood of needing support; the benefits from receiving support; and the costs of providing support. Hypotheses are based on a

  10. A microcatalytic flow reactor for the study of heterogeneous catalytic reactions at elevated pressures

    Energy Technology Data Exchange (ETDEWEB)

    Belyi, A S; Fomichev, Yu V; Duplyakin, V K; Alfeev, V S

    1977-07-01

    A microcatalytic flow reactor for the study of heterogeneous catalytic reactions at elevated pressures (i.e., up to 40 atm) and nearly isothermal conditions up to 600/sup 0/C was designed for the conversion of small quantities of petrochemical feeds or feed mixtures at uniform, controllable flow rates of 0.5-5.0 cc/hr, for direct gas-chromatographic analysis of product samples at the reactor outlet, and for continuous monitoring of the degree of conversion in processes that evolve or absorb hydrogen. The device includes a feed injection system with a unique sealing feature that ensures a constant flow of liquid from a feed buret under positive displacement by a counterweight piston at very low rates into a tubular reactor of the perfect mixing type, a highly efficient vaporizer-mixer, and a two-channel sampler leading to the chromatograph. The apparatus has proved reliable, accurate, and convenient in two years of regular use. Diagrams.

  11. First Principles Molecular Dynamics Study of Catalysis for Polyolefins: the Ziegler-Natta Heterogeneous System.

    Directory of Open Access Journals (Sweden)

    Michele Parrinello

    2002-04-01

    Full Text Available Abstract: We review part of our recent ab initio molecular dynamics study on the Ti-based Ziegler-Natta supported heterogeneous catalysis of α-olefins. The results for the insertion of ethylene in the metal-carbon bond are discussed as a fundamental textbook example of polymerization processes. Comparison with the few experimental data available has shown that simulation can reproduce activation barriers and the overall energetics of the reaction with sufficient accuracy. This puts these quantum dynamical simulations in a new perspective as a virtual laboratory where the microscopic picture of the catalysis, which represents an important issue that still escapes experimental probes, can be observed and understood. These results are then discussed in comparison with a V-based catalyst in order to figure out analogies and differences with respect to the industrially more successful Tibased systems.

  12. First principles study of propene polymerization in Ziegler-Natta heterogeneous catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Boero, M.; Parrinello, M.; Hueffer, S.; Weiss, H.

    2000-01-26

    In this work the authors address the problem of isotacticity in a realistic heterogeneous Ziegler-Natta system by means of ab initio molecular dynamics. A previously identified 5-fold catalytic center was selected and examined for its ability to select the appropriate olefin enantioface in the chain growth process. The first steps in the propene polymerization process were studied to determine the energetics of the initial complexation phase for the different stereochemical orientations of the incoming propene. Then the authors analyze the subsequent insertions which represent the crucial issue for the formation of a stereospecific polymer chain, and find that the 5-fold catalytic center possesses a huge degree of stereoselectivity. The role of the agostic interaction was examined which can switch from {alpha} to {beta} and allow, even in the presence of a substrate, process that can lead to chain termination.

  13. Heterogeneity of the jealousy phenomenon in the general population: an Italian study.

    Science.gov (United States)

    Marazziti, Donatella; Sbrana, Alfredo; Rucci, Paola; Cherici, Luca; Mungai, Francesco; Gonnelli, Chiara; Massimetti, Enrico; Raimondi, Francesca; Doria, Maria Rosaria; Spagnolli, Sabrina; Ravani, Laura; Consoli, Giorgio; Catena Dell Osso, Mario

    2010-01-01

    Despite the general agreement that normal jealousy is heterogenous, little is known about this specific topic. In the present study, we explored the possibility of distinguishing between four subtypes of "normal" jealousy (depressive, anxious, obsessive, and paranoid) amongst a cohort of 500 healthy university students by means of a specifically designed questionnaire, "Ouestionario della gelosia" (QUEGE). QUEGE is a self-report instrument of 30 items which explores the presence, frequency, and duration of feelings and behaviors related to jealousy. It was devised to investigate four hypothetical psychopathological profiles: depressive, paranoid, obsessive, and anxious. The factor analysis identified five rather than four clear-cut factors: self-esteem, paranoia, interpersonal Sensitivity, fear of being abandoned, and obsessionality. Women showed statistically significant lower levels of self-esteem and higher levels of obsessionality than men. Younger age (jealousy phenomenon in the general population.

  14. Kinetic Study on the Esterification of Palm Fatty Acid Distillate (PFAD) Using Heterogeneous Catalyst

    Science.gov (United States)

    Rofiqah, U.; Djalal, R. A.; Sutrisno, B.; Hidayat, A.

    2018-05-01

    Esterification with heterogeneous catalysts is believed to have advantages compared to homogeneous catalysts. Palm Fatty Acid Distillate (PFAD) was esterified by ZrO2 -SO4 2-/natural zeolite at temperature variation of 55°C, 60°C, and 65°C to produce biodiesel. Determination of reaction kinetics was done by experiment and modeling. Kinetic study was approached using pseudo-homogeneous model of first order. For experiment, reaction kinetics were 0.0031 s-1, 0.0054 s-1, and 0.00937 s-1 for a temperature of 55 °C, 60 °C and 65 °C, respectively. For modelling, reaction kinetics were 0.0030 s-1, 0.0055 s-1, and 0.0090 s-1 for a temperature of 55°C, 60°C and 65°C, respectively. Rate and conversion of reaction are getting increased by increasing temperature.

  15. Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations.

    Science.gov (United States)

    Dinov, Ivo D; Heavner, Ben; Tang, Ming; Glusman, Gustavo; Chard, Kyle; Darcy, Mike; Madduri, Ravi; Pa, Judy; Spino, Cathie; Kesselman, Carl; Foster, Ian; Deutsch, Eric W; Price, Nathan D; Van Horn, John D; Ames, Joseph; Clark, Kristi; Hood, Leroy; Hampstead, Benjamin M; Dauer, William; Toga, Arthur W

    2016-01-01

    A unique archive of Big Data on Parkinson's Disease is collected, managed and disseminated by the Parkinson's Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationship of Parkinson's disease (PD) risk to trauma, genetics, environment, co-morbidities, or life style. The defining characteristics of Big Data-large size, incongruency, incompleteness, complexity, multiplicity of scales, and heterogeneity of information-generating sources-all pose challenges to the classical techniques for data management, processing, visualization and interpretation. We propose, implement, test and validate complementary model-based and model-free approaches for PD classification and prediction. To explore PD risk using Big Data methodology, we jointly processed complex PPMI imaging, genetics, clinical and demographic data. Collective representation of the multi-source data facilitates the aggregation and harmonization of complex data elements. This enables joint modeling of the complete data, leading to the development of Big Data analytics, predictive synthesis, and statistical validation. Using heterogeneous PPMI data, we developed a comprehensive protocol for end-to-end data characterization, manipulation, processing, cleaning, analysis and validation. Specifically, we (i) introduce methods for rebalancing imbalanced cohorts, (ii) utilize a wide spectrum of classification methods to generate consistent and powerful phenotypic predictions, and (iii) generate reproducible machine-learning based classification that enables the reporting of model parameters and diagnostic forecasting based on new data. We evaluated several complementary model-based predictive approaches

  16. Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations.

    Directory of Open Access Journals (Sweden)

    Ivo D Dinov

    Full Text Available A unique archive of Big Data on Parkinson's Disease is collected, managed and disseminated by the Parkinson's Progression Markers Initiative (PPMI. The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationship of Parkinson's disease (PD risk to trauma, genetics, environment, co-morbidities, or life style. The defining characteristics of Big Data-large size, incongruency, incompleteness, complexity, multiplicity of scales, and heterogeneity of information-generating sources-all pose challenges to the classical techniques for data management, processing, visualization and interpretation. We propose, implement, test and validate complementary model-based and model-free approaches for PD classification and prediction. To explore PD risk using Big Data methodology, we jointly processed complex PPMI imaging, genetics, clinical and demographic data.Collective representation of the multi-source data facilitates the aggregation and harmonization of complex data elements. This enables joint modeling of the complete data, leading to the development of Big Data analytics, predictive synthesis, and statistical validation. Using heterogeneous PPMI data, we developed a comprehensive protocol for end-to-end data characterization, manipulation, processing, cleaning, analysis and validation. Specifically, we (i introduce methods for rebalancing imbalanced cohorts, (ii utilize a wide spectrum of classification methods to generate consistent and powerful phenotypic predictions, and (iii generate reproducible machine-learning based classification that enables the reporting of model parameters and diagnostic forecasting based on new data. We evaluated several complementary model

  17. Study of some physiological parameters among mobile phone users

    International Nuclear Information System (INIS)

    Anwar, S.M.; Gabr, S.A.

    2002-01-01

    Forty male mobile users in additional to twenty males as control group similar in age and socio economically matched were chosen for this study. Blood pressure, complete blood picture, five parameters of semen quality and four sex hormones (LH, FSH, prolactin and testosterone)were measured. Elevated significant differences for blood pressure (P<0.01) for the exposed group and some changes in mean values of haematologic parameters, although all values were within the normal range. Minor semen quality and hormonal levels changes between the two groups, including a higher mean follicle-stimulating hormone level; for mobile users (8.10 vs 6.00 mIU/mL), and a slightly higher mean luteinizing hormone level (11.73 vs 10.16 mLU/mL) were noted in the user group

  18. Seismic analysis of steam generator and parameter sensitivity studies

    International Nuclear Information System (INIS)

    Qian Hao; Xu Dinggen; Yang Ren'an; Liang Xingyun

    2013-01-01

    Background: The steam generator (SG) serves as the primary means for removing the heat generated within the reactor core and is part of the reactor coolant system (RCS) pressure boundary. Purpose: Seismic analysis in required for SG, whose seismic category is Cat. I. Methods: The analysis model of SG is created with moisture separator assembly and tube bundle assembly herein. The seismic analysis is performed with RCS pipe and Reactor Pressure Vessel (RPV). Results: The seismic stress results of SG are obtained. In addition, parameter sensitivities of seismic analysis results are studied, such as the effect of another SG, support, anti-vibration bars (AVBs), and so on. Our results show that seismic results are sensitive to support and AVBs setting. Conclusions: The guidance and comments on these parameters are summarized for equipment design and analysis, which should be focused on in future new type NPP SG's research and design. (authors)

  19. Study on Two-Phase Flow in Heterogeneous Porous Media by Light Transmission Method

    Science.gov (United States)

    Qiao, W.

    2015-12-01

    The non-aqueous phase liquid (NAPL) released to the subsurface can form residual ganglia and globules occupying pores and also accumulate and form pools, in which multiphase system forms. Determining transient fluid saturations in a multiphase system is essential to understand the flow characteristics of systems and to perform effective remediation strategies. As a non-destructive and non-invasive laboratory technique utilized for the measurement of liquid saturation in porous media, light transmission is of the lowest cost and safe. Utilization of Coupled Charge Device camera in light transmission systems provides a nearly instantaneous high-density array of spatial measurements over a very large dynamic range. The migration of NAPL and air spariging technique applied to remove NAPL in aquifer systems are typically two-phase flow problem. Because of the natural aquifer normally being heterogeneous, two 2-D sandboxes (Length55cm×width1.3cm×hight45cm) are set up to study the migration of gas and DNAPL in heterogeneous porous media based on light transmission method and its application in two-phase flow. Model D for water/gas system developed by Niemet and Selker (2001) and Model NW-A for water/NAPL system developed by Zhang et al. (2014) are applied for the calculation of fluid saturation in the two experiments, respectively. The gas injection experiments show that the gas moves upward in the irregular channels, piling up beneath the low permeability lenses and starting lateral movement. Bypassing the lenses, the gas moves upward and forms continuous distribution in the top of the sandbox. The faster of gas injects, the wider of gas migration will be. The DNAPL infiltration experiment shows that TCE mainly moves downward as the influence of gravity, stopping vertical infiltration when reaching the low permeability lenses because of its failure to overcome the capillary pressure. Then, TCE accumulates on the surface and starts transverse movement. Bypassing the

  20. POPULATION SYNTHESIS OF HOT SUBDWARFS: A PARAMETER STUDY

    International Nuclear Information System (INIS)

    Clausen, Drew; Wade, Richard A.; Kopparapu, Ravi Kumar; O'Shaughnessy, Richard

    2012-01-01

    Binaries that contain a hot subdwarf (sdB) star and a main-sequence companion may have interacted in the past. This binary population has historically helped determine our understanding of binary stellar evolution. We have computed a grid of binary population synthesis models using different assumptions about the minimum core mass for helium ignition, the envelope binding energy, the common-envelope ejection efficiency, the amount of mass and angular momentum lost during stable mass transfer, and the criteria for stable mass transfer on the red giant branch and in the Hertzsprung gap. These parameters separately and together can significantly change the entire predicted population of sdBs. Nonetheless, several different parameter sets can reproduce the observed subpopulation of sdB + white dwarf and sdB + M dwarf binaries, which has been used to constrain these parameters in previous studies. The period distribution of sdB + early F dwarf binaries offers a better test of different mass transfer scenarios for stars that fill their Roche lobes on the red giant branch.

  1. Study of Temperature Coefficients for Parameters of Photovoltaic Cells

    Directory of Open Access Journals (Sweden)

    Daniel Tudor Cotfas

    2018-01-01

    Full Text Available The temperature is one of the most important factors which affect the performance of the photovoltaic cells and panels along with the irradiance. The current voltage characteristics, I-V, are measured at different temperatures from 25°C to 87°C and at different illumination levels from 400 to 1000 W/m2, because there are locations where the upper limit of the photovoltaic cells working temperature exceeds 80°C. This study reports the influence of the temperature and the irradiance on the important parameters of four commercial photovoltaic cell types: monocrystalline silicon—mSi, polycrystalline silicon—pSi, amorphous silicon—aSi, and multijunction InGaP/InGaAs/Ge (Emcore. The absolute and normalized temperature coefficients are determined and compared with their values from the related literature. The variation of the absolute temperature coefficient function of the irradiance and its significance to accurately determine the important parameters of the photovoltaic cells are also presented. The analysis is made on different types of photovoltaics cells in order to understand the effects of technology on temperature coefficients. The comparison between the open-circuit voltage and short-circuit current was also performed, calculated using the temperature coefficients, determined, and measured, in various conditions. The measurements are realized using the SolarLab system, and the photovoltaic cell parameters are determined and compared using the LabVIEW software created for SolarLab system.

  2. Numerical Study of Critical Role of Rock Heterogeneity in Hydraulic Fracture Propagation

    Energy Technology Data Exchange (ETDEWEB)

    J. Zhou; H. Huang; M. Deo

    2016-03-01

    Log and seismic data indicate that most shale formations have strong heterogeneity. Conventional analytical and semi-analytical fracture models are not enough to simulate the complex fracture propagation in these highly heterogeneous formation. Without considering the intrinsic heterogeneity, predicted morphology of hydraulic fracture may be biased and misleading in optimizing the completion strategy. In this paper, a fully coupling fluid flow and geomechanics hydraulic fracture simulator based on dual-lattice Discrete Element Method (DEM) is used to predict the hydraulic fracture propagation in heterogeneous reservoir. The heterogeneity of rock is simulated by assigning different material force constant and critical strain to different particles and is adjusted by conditioning to the measured data and observed geological features. Based on proposed model, the effects of heterogeneity at different scale on micromechanical behavior and induced macroscopic fractures are examined. From the numerical results, the microcrack will be more inclined to form at the grain weaker interface. The conventional simulator with homogeneous assumption is not applicable for highly heterogeneous shale formation.

  3. Temporal and spatial heterogeneity analysis of optimal value of sensitive parameters in ecological process model: The BIOME-BGC model as an example%生态过程模型敏感参数最优取值的时空异质性分析——以BIOME-BGC模型为例

    Institute of Scientific and Technical Information of China (English)

    李一哲; 张廷龙; 刘秋雨; 李英

    2018-01-01

    The ecological process models are powerful tools for studying terrestrial ecosystem water and carbon cycle at present.However,there are many parameters for these models,and weather the reasonable values of these parameters were taken,have important impact on the models simulation results.In the past,the sensitivity and the optimization of model parameters were analyzed and discussed in many researches.But the temporal and spatial heterogeneity of the optimal parameters is less concerned.In this paper,the BIOME-BGC model was used as an example.In the evergreen broad-leaved forest,deciduous broad-leaved forest and C3 grassland,the sensitive parameters of the model were selected by constructing the sensitivity judgment index with two experimental sites selected under each vegetation type.The objective function was constructed by using the simulated annealing algorithm combined with the flux data to obtain the monthly optimal values of the sensitive parameters at each site.Then we constructed the temporal heterogeneity judgment index,the spatial heterogeneity judgment index and the temporal and spatial heterogeneity judgment index to quantitatively analyze the temporal and spatial heterogeneity of the optimal values of the model sensitive parameters.The results showed that the sensitivity of BIOME-BGC model parameters was different under different vegetation types,but the selected sensitive parameters were mostly consistent.The optimal values of the sensitive parameters of BIOME-BGC model mostly presented time-space heterogeneity to different degrees which varied with vegetation types.The sensitive parameters related to vegetation physiology and ecology had relatively little temporal and spatial heterogeneity while those related to environment and phenology had generally larger temporal and spatial heterogeneity.In addition,the temporal heterogeneity of the optimal values of the model sensitive parameters showed a significant linear correlation with the spatial

  4. Capturing heterogeneity: The role of a study area's extent for estimating mean throughfall

    Science.gov (United States)

    Zimmermann, Alexander; Voss, Sebastian; Metzger, Johanna Clara; Hildebrandt, Anke; Zimmermann, Beate

    2016-11-01

    The selection of an appropriate spatial extent of a sampling plot is one among several important decisions involved in planning a throughfall sampling scheme. In fact, the choice of the extent may determine whether or not a study can adequately characterize the hydrological fluxes of the studied ecosystem. Previous attempts to optimize throughfall sampling schemes focused on the selection of an appropriate sample size, support, and sampling design, while comparatively little attention has been given to the role of the extent. In this contribution, we investigated the influence of the extent on the representativeness of mean throughfall estimates for three forest ecosystems of varying stand structure. Our study is based on virtual sampling of simulated throughfall fields. We derived these fields from throughfall data sampled in a simply structured forest (young tropical forest) and two heterogeneous forests (old tropical forest, unmanaged mixed European beech forest). We then sampled the simulated throughfall fields with three common extents and various sample sizes for a range of events and for accumulated data. Our findings suggest that the size of the study area should be carefully adapted to the complexity of the system under study and to the required temporal resolution of the throughfall data (i.e. event-based versus accumulated). Generally, event-based sampling in complex structured forests (conditions that favor comparatively long autocorrelations in throughfall) requires the largest extents. For event-based sampling, the choice of an appropriate extent can be as important as using an adequate sample size.

  5. A conceptual sedimentological-geostatistical model of aquifer heterogeneity based on outcrop studies

    International Nuclear Information System (INIS)

    Davis, J.M.

    1994-01-01

    Three outcrop studies were conducted in deposits of different depositional environments. At each site, permeability measurements were obtained with an air-minipermeameter developed as part of this study. In addition, the geological units were mapped with either surveying, photographs, or both. Geostatistical analysis of the permeability data was performed to estimate the characteristics of the probability distribution function and the spatial correlation structure. The information obtained from the geological mapping was then compared with the results of the geostatistical analysis for any relationships that may exist. The main field site was located in the Albuquerque Basin of central New Mexico at an outcrop of the Pliocene-Pleistocene Sierra Ladrones Formation. The second study was conducted on the walls of waste pits in alluvial fan deposits at the Nevada Test Site. The third study was conducted on an outcrop of an eolian deposit (miocene) south of Socorro, New Mexico. The results of the three studies were then used to construct a conceptual model relating depositional environment to geostatistical models of heterogeneity. The model presented is largely qualitative but provides a basis for further hypothesis formulation and testing

  6. A conceptual sedimentological-geostatistical model of aquifer heterogeneity based on outcrop studies

    Energy Technology Data Exchange (ETDEWEB)

    Davis, J.M.

    1994-01-01

    Three outcrop studies were conducted in deposits of different depositional environments. At each site, permeability measurements were obtained with an air-minipermeameter developed as part of this study. In addition, the geological units were mapped with either surveying, photographs, or both. Geostatistical analysis of the permeability data was performed to estimate the characteristics of the probability distribution function and the spatial correlation structure. The information obtained from the geological mapping was then compared with the results of the geostatistical analysis for any relationships that may exist. The main field site was located in the Albuquerque Basin of central New Mexico at an outcrop of the Pliocene-Pleistocene Sierra Ladrones Formation. The second study was conducted on the walls of waste pits in alluvial fan deposits at the Nevada Test Site. The third study was conducted on an outcrop of an eolian deposit (miocene) south of Socorro, New Mexico. The results of the three studies were then used to construct a conceptual model relating depositional environment to geostatistical models of heterogeneity. The model presented is largely qualitative but provides a basis for further hypothesis formulation and testing.

  7. Study on parameter identification and control of ground temperature

    International Nuclear Information System (INIS)

    Kojima, Keiichi; Suzuki, Seiichi; Kawahara, Mutsuto.

    1995-01-01

    A numerical thermal management system for ground structure is presented. The system consists of two parts, i.e. the identification analysis of the thermal conductivity and the thermal control analysis for the ground. The former is carried out by using the nonlinear least squares method and the latter is based on the optimal control theory. The formulations of these methods are presented and they are applied to an laboratory test. A reasonable thermal conductivity of the ground is identified by parameter estimation method and the ground temperature is actually controled as illustrated by numerical and experimental study. (author)

  8. Studying the noise parameters of thin-film silicon resistors

    International Nuclear Information System (INIS)

    Belogurov, S.V.; Gostilo, V.V.; Yurov, A.S.

    1986-01-01

    The results of studies on spectral density and energy noise equivalent of thin-film resistors on the base of amorphous silicon and KIM and KVM commercial high-ohmic resistors are presented. Dependence of the active part of impedance on frequency is shown to be the main source of redundant noise in resistors. Dependence of spectral density of noise voltage of current noises of silicon resistors on applied voltage is described by the formula S T =B V 2 /f 1.6 with the values B=(1.4-1.7)x10 -12 Hz 0.6 . As to noise parameters the silicon resistor is superior to commercial resistors

  9. Study of nuclear level density parameter and its temperature dependence

    International Nuclear Information System (INIS)

    Nasrabadi, M. N.; Behkami, A. N.

    2000-01-01

    The nuclear level density ρ is the basic ingredient required for theoretical studies of nuclear reaction and structure. It describes the statistical nuclear properties and is expressed as a function of various constants of motion such as number of particles, excitation energy and angular momentum. In this work the energy and spin dependence of nuclear level density will be presented and discussed. In addition the level density parameter α will be extracted from this level density information, and its temperature and mass dependence will be obtained

  10. Characterizing parameters of Jatropha curcas cell cultures for microgravity studies

    Science.gov (United States)

    Vendrame, Wagner A.; Pinares, Ania

    2013-06-01

    Jatropha (Jatropha curcas) is a tropical perennial species identified as a potential biofuel crop. The oil is of excellent quality and it has been successfully tested as biodiesel and in jet fuel mixes. However, studies on breeding and genetic improvement of jatropha are limited. Space offers a unique environment for experiments aiming at the assessment of mutations and differential gene expression of crops and in vitro cultures of plants are convenient for studies of genetic variation as affected by microgravity. However, before microgravity studies can be successfully performed, pre-flight experiments are necessary to characterize plant material and validate flight hardware environmental conditions. Such preliminary studies set the ground for subsequent spaceflight experiments. The objectives of this study were to compare the in vitro growth of cultures from three explant sources (cotyledon, leaf, and stem sections) of three jatropha accessions (Brazil, India, and Tanzania) outside and inside the petriGAP, a modified group activation pack (GAP) flight hardware to fit petri dishes. In vitro jatropha cell cultures were established in petri dishes containing a modified MS medium and maintained in a plant growth chamber at 25 ± 2 °C in the dark. Parameters evaluated were surface area of the explant tissue (A), fresh weight (FW), and dry weight (DW) for a period of 12 weeks. Growth was observed for cultures from all accessions at week 12, including subsequent plantlet regeneration. For all accessions differences in A, FW and DW were observed for inside vs. outside the PetriGAPs. Growth parameters were affected by accession (genotype), explant type, and environment. The type of explant influenced the type of cell growth and subsequent plantlet regeneration capacity. However, overall cell growth showed no abnormalities. The present study demonstrated that jatropha in vitro cell cultures are suitable for growth inside PetriGAPs for a period of 12 weeks. The parameters

  11. Heterogeneity of Human Research Ethics Committees and Research Governance Offices across Australia: An observational study.

    Science.gov (United States)

    De Smit, Elisabeth; Kearns, Lisa S; Clarke, Linda; Dick, Jonathan; Hill, Catherine L; Hewitt, Alex W

    2016-01-01

    Conducting ethically grounded research is a fundamental facet of all investigations. Nevertheless, the administrative burdens of current ethics review are substantial, and calls have been made for a reduction in research waste. To describe the heterogeneity in administration and documentation required by Human Research Ethics Committees (HRECs) and Research Governance Offices (RGOs) across Australia. In establishing a nationwide study to investigate the molecular aetiology of Giant Cell Arteritis (GCA), for which archived pathological specimens from around Australia are being recruited, we identified variation across separate HREC and RGO requirements. Submission paperwork and correspondence from each collaborating site and its representative office for research were reviewed. This data was interrogated to evaluate differences in current guidelines. Twenty-five pathology departments across seven Australian States collaborated in this study. All states, except Victoria, employed a single ethics review model. There was discrepancy amongst HRECs as to which application process applied to our study: seven requested completion of a "National Ethics Application Form" and three a "Low Negligible Risk" form. Noticeable differences in guidelines included whether electronic submission was sufficient. There was variability in the total number of documents submitted (range five to 22) and panel review turnaround time (range nine to 136 days). We demonstrate the challenges and illustrate the heavy workload involved in receiving widespread ethics and governance approval across Australia. We highlight the need to simplify, homogenise, and nationalise human ethics for non-clinical trial studies. Reducing unnecessary administration will enable investigators to achieve research aims more efficiently.

  12. Parameter uncertainty in simulations of extreme precipitation and attribution studies.

    Science.gov (United States)

    Timmermans, B.; Collins, W. D.; O'Brien, T. A.; Risser, M. D.

    2017-12-01

    The attribution of extreme weather events, such as heavy rainfall, to anthropogenic influence involves the analysis of their probability in simulations of climate. The climate models used however, such as the Community Atmosphere Model (CAM), employ approximate physics that gives rise to "parameter uncertainty"—uncertainty about the most accurate or optimal values of numerical parameters within the model. In particular, approximate parameterisations for convective processes are well known to be influential in the simulation of precipitation extremes. Towards examining the impact of this source of uncertainty on attribution studies, we investigate the importance of components—through their associated tuning parameters—of parameterisations relating to deep and shallow convection, and cloud and aerosol microphysics in CAM. We hypothesise that as numerical resolution is increased the change in proportion of variance induced by perturbed parameters associated with the respective components is consistent with the decreasing applicability of the underlying hydrostatic assumptions. For example, that the relative influence of deep convection should diminish as resolution approaches that where convection can be resolved numerically ( 10 km). We quantify the relationship between the relative proportion of variance induced and numerical resolution by conducting computer experiments that examine precipitation extremes over the contiguous U.S. In order to mitigate the enormous computational burden of running ensembles of long climate simulations, we use variable-resolution CAM and employ both extreme value theory and surrogate modelling techniques ("emulators"). We discuss the implications of the relationship between parameterised convective processes and resolution both in the context of attribution studies and progression towards models that fully resolve convection.

  13. Study of some parameters of the fibrinogen - fibrin transformation reaction

    International Nuclear Information System (INIS)

    Hollard, D.; Suscillon, M.; Marcille, G.; Rambaud, F.; Baloyan, M.

    1966-01-01

    The authors studied the action of some parameters on the reaction of transformation fibrinogen-fibrin. The five parameters studied are: the concentration of substratum: a certain quantity of enzyme determines an optimum quantity of fibrinogen; the concentration of enzyme: a certain quantity of substratum defines an optimum quantity of enzyme, beyond which the excess of enzyme is unable to act, the substratum being saturated by the enzyme; the concentration of Ca ions: between 0,07 and 0,10 mg of Ca by mg of fibrinogen, the reaction appears with a great speed. Between 0,02 and 0,40 mg of Ca by mg of fibrinogen the fibrin stabilisation is possible, the FSF can act only inside the definite bounds; the ph of the solution: the reaction of the transformation appears with its maximum intensity on physiological ph, the polymerisation is not possible on acid ph; the temperature has an effect which could not really be verified owing to the fact that the technical realisation is difficult. (author) [fr

  14. A Preliminary Study on the Multiple Mapping Structure of Classification Systems for Heterogeneous Databases

    Directory of Open Access Journals (Sweden)

    Seok-Hyoung Lee

    2012-06-01

    Full Text Available While science and technology information service portals and heterogeneous databases produced in Korea and other countries are integrated, methods of connecting the unique classification systems applied to each database have been studied. Results of technologists' research, such as, journal articles, patent specifications, and research reports, are organically related to each other. In this case, if the most basic and meaningful classification systems are not connected, it is difficult to achieve interoperability of the information and thus not easy to implement meaningful science technology information services through information convergence. This study aims to address the aforementioned issue by analyzing mapping systems between classification systems in order to design a structure to connect a variety of classification systems used in the academic information database of the Korea Institute of Science and Technology Information, which provides science and technology information portal service. This study also aims to design a mapping system for the classification systems to be applied to actual science and technology information services and information management systems.

  15. Heterogeneity in small aliquots of Apolllo 15 olivine-normative basalt: Implications for breccia clast studies

    Science.gov (United States)

    Lindstrom, Marilyn M.; Shervais, John W.; Vetter, Scott K.

    1993-01-01

    Most of the recent advances in lunar petrology are the direct result of breccia pull-apart studies, which have identified a wide array of new highland and mare basalt rock types that occur only as clasts within the breccias. These rocks show that the lunar crust is far more complex than suspected previously, and that processes such as magma mixing and wall-rock assimilation were important in its petrogenesis. These studies are based on the implicit assumption that the breccia clasts, which range in size from a few mm to several cm across, are representative of the parent rock from which they were derived. In many cases, the aliquot allocated for analysis may be only a few grain diameters across. While this problem is most acute for coarse-grained highland rocks, it can also cause considerable uncertainty in the analysis of mare basalt clasts. Similar problems arise with small aliquots of individual hand samples. Our study of sample heterogeneity in 9 samples of Apollo 15 olivine normative basalt (ONB) which exhibit a range in average grain size from coarse to fine are reported. Seven of these samples have not been analyzed previously, one has been analyzed by INAA only, and one has been analyzed by XRF+INAA. Our goal is to assess the effects of small aliquot size on the bulk chemistry of large mare basalt samples, and to extend this assessment to analyses of small breccia clasts.

  16. Thermodynamics of Macromolecular Association in Heterogeneous Crowding Environments: Theoretical and Simulation Studies with a Simplified Model.

    Science.gov (United States)

    Ando, Tadashi; Yu, Isseki; Feig, Michael; Sugita, Yuji

    2016-11-23

    The cytoplasm of a cell is crowded with many different kinds of macromolecules. The macromolecular crowding affects the thermodynamics and kinetics of biological reactions in a living cell, such as protein folding, association, and diffusion. Theoretical and simulation studies using simplified models focus on the essential features of the crowding effects and provide a basis for analyzing experimental data. In most of the previous studies on the crowding effects, a uniform crowder size is assumed, which is in contrast to the inhomogeneous size distribution of macromolecules in a living cell. Here, we evaluate the free energy changes upon macromolecular association in a cell-like inhomogeneous crowding system via a theory of hard-sphere fluids and free energy calculations using Brownian dynamics trajectories. The inhomogeneous crowding model based on 41 different types of macromolecules represented by spheres with different radii mimics the physiological concentrations of macromolecules in the cytoplasm of Mycoplasma genitalium. The free energy changes of macromolecular association evaluated by the theory and simulations were in good agreement with each other. The crowder size distribution affects both specific and nonspecific molecular associations, suggesting that not only the volume fraction but also the size distribution of macromolecules are important factors for evaluating in vivo crowding effects. This study relates in vitro experiments on macromolecular crowding to in vivo crowding effects by using the theory of hard-sphere fluids with crowder-size heterogeneity.

  17. Rock Physics and Petrographic Parameters Relationship Within Siliciclastic Rocks: Quartz Sandstone Outcrop Study Case

    Science.gov (United States)

    Syafriyono, S.; Caesario, D.; Swastika, A.; Adlan, Q.; Syafri, I.; Abdurrokhim, A.; Mardiana, U.; Mohamad, F.; Alfadli, M. K.; Sari, V. M.

    2018-03-01

    Rock physical parameters value (Vp and Vs) is one of fundamental aspects in reservoir characterization as a tool to detect rock heterogenity. Its response is depend on several reservoir conditions such as lithology, pressure and reservoir fluids. The value of Vp and Vs is controlled by grain contact and contact stiffness, a function of clay mineral content and porosity also affected by mineral composition. The study about Vp and Vs response within sandstone and its relationship with petrographic parameters has become important to define anisotrophy of reservoir characteristics distribution and could give a better understanding about local diagenesis that influence clastic reservoir properties. Petrographic analysis and Vp-Vs calculation was carried out to 12 core sample which is obtained by hand-drilling of the outcrop in Sukabumi area, West Java as a part of Bayah Formation. Data processing and interpretation of sedimentary vertical succession showing that this outcrop comprises of 3 major sandstone layers indicating fluvial depositional environment. As stated before, there are 4 petrographic parameters (sorting, roundness, clay mineral content, and grain contact) which are responsible to the differences of shear wave and compressional wave value in this outcrop. Lithology with poor-sorted and well- roundness has Vp value lower than well-sorted and poor-roundness (sub-angular) grain. For the sample with high clay content, Vp value is ranging from 1681 to 2000 m/s and could be getting high until 2190 to 2714 m/s in low clay content sample even though the presence of clay minerals cannot be defined neither as matrix nor cement. The whole sample have suture grain contact indicating telogenesis regime whereas facies has no relationship with Vp and Vs value because of the different type of facies show similar petrographic parameters after diagenesis.

  18. Study of the heterogeneities effect in the dose distributions of Leksell Gamma Knife (R), through Monte Carlo simulation

    International Nuclear Information System (INIS)

    Rojas C, E.L.; Al-Dweri, F.M.O.; Lallena R, A.M.

    2005-01-01

    In this work they are studied, by means of Monte Carlo simulation, the effects that take place in the dose profiles that are obtained with the Leksell Gamma Knife (R), when they are kept in account heterogeneities. The considered heterogeneities simulate the skull and the spaces of air that are in the head, like they can be the nasal breasts or the auditory conduits. The calculations were made using the Monte Carlo Penelope simulation code (v. 2003). The geometry of each one of the 201 sources that this instrument is composed, as well as of the corresponding channels of collimation of the Gamma Knife (R), it was described by means of a simplified model of geometry that has been recently studied. The obtained results when they are kept in mind the heterogeneities they present non worthless differences regarding those obtained when those are not considered. These differences are maximum in the proximities of the interfaces among different materials. (Author)

  19. Study on Parameters Modeling of Wind Turbines Using SCADA Data

    Directory of Open Access Journals (Sweden)

    Yonglong YAN

    2014-08-01

    Full Text Available Taking the advantage of the current massive monitoring data from Supervisory Control and Data Acquisition (SCADA system of wind farm, it is of important significance for anomaly detection, early warning and fault diagnosis to build the data model of state parameters of wind turbines (WTs. The operational conditions and the relationships between the state parameters of wind turbines are complex. It is difficult to establish the model of state parameter accurately, and the modeling method of state parameters of wind turbines considering parameter selection is proposed. Firstly, by analyzing the characteristic of SCADA data, a reasonable range of data and monitoring parameters are chosen. Secondly, neural network algorithm is adapted, and the selection method of input parameters in the model is presented. Generator bearing temperature and cooling air temperature are regarded as target parameters, and the two models are built and input parameters of the models are selected, respectively. Finally, the parameter selection method in this paper and the method using genetic algorithm-partial least square (GA-PLS are analyzed comparatively, and the results show that the proposed methods are correct and effective. Furthermore, the modeling of two parameters illustrate that the method in this paper can applied to other state parameters of wind turbines.

  20. Studying A Portrait of the Artist as a Young Man through Heterogeneous Philosophy of Georges Bataille

    Directory of Open Access Journals (Sweden)

    Shataw Naseri

    2014-09-01

    Full Text Available Georges Bataille believes that most of his contemporary discourses were spiritual and/or intellectual ones. They were, for him, vegetation-like discourses looking upward and underlining the role of head and thinking in their paradigms. He, instead, introduced the notion of "base materialism" which highlights the role of the lower parts of the body; it is here that Bataille raises the notion of "Acéphale" who has beheaded himself with a dagger in his right hand, and thus has beheaded the ruling head of his own body as well as the heads of his surrounding social discourses. For George Bataille, humans are linguistic being entrapped forever in a language system. However, he believes that this system is full of fissures and that through transgressive moments one can experience these voids within language. Through transgression one can look directly in the abyss of language, though he/she cannot see the extremity of these voids and thus Bataille believes that one cannot reach any signified, and therefore, any Bataillean "Impossible." As one can witness, linguistic human being is entrapped within narratives of language system defining him in terms of cause and effect and their related items namely linear time and space. Georges Bataille believes that any heterogeneous element which crosses the defined taboos of the body of self and society at some transgressive moments is regarded as a "foreign body" and an "alterity." This foreign body, as he regards, at the instants of transgression experiences "sovereignty" which means that he is at the epic of being a "sovereign being," of course momentarily, because he at those moments has stepped upon any ruling borders and is bound with no taboo and thus is the "sovereign" of instants. The present study endeavors to analyze Stephen Dedalus in A Portrait of the Artist as a Young Man and his Bataillean experiences in terms of narrative and language. A Portrait will be concentrated in the light of the

  1. Studies on some biochemical parameters in viral hepatitis patients

    International Nuclear Information System (INIS)

    El-Sherbiny, E.M.

    2002-01-01

    The present investigation deals with studying liver amino transferases (ALT. AST). Cholesterol and triglycerides. As well as testosterone and protection hormones in blood of Egyptian men infected with hepatitis C virus.hepatitis B virus and mixed B and C viruses. These biochemical parameters were evaluated to be used in diagnosis and prognosis of viral hepatitis. Which considered the most important health problem in Egypt and developing countries. Biochemical analysis were performed using spectrophotometric and radioimmunoassay techniques. All data will be subjected to statistical analysis in order to detect the most suitable biochemical analysis that can be used as specific tests for early diagnosis of viral hepatitis and to detect the parameters that show abnormalities among the different groups of infected patients. The data revealed that AST and ALT levels were increased in all patient groups. Concerning the level of triglycerides, it was increased only in the group of mixed viral hepatitis B and C, while cholesterol showed non-significant changes in all viral hepatitis groups. The sex hormone testosterone was decreased in all infected patients while the prolactin level was increased only in case of patients infected with mixed B and C viruses. However, these abnormal values in such sex hormones play a serious role in male sterility

  2. ESR study into mechanism of heterogeneous-catalytic oxidation on oxides

    Energy Technology Data Exchange (ETDEWEB)

    Topchieva, K V; Loginov, A Yu; Kostikov, S V [Moskovskij Gosudarstvennyj Univ. (USSR)

    1977-12-11

    The role of radical particles in heterogeneous-catalytic oxidation of H/sub 2/; CO; SO/sub 2/; NH/sub 3/; C/sub 3/H/sub 6/ on the rare earth oxides (yttrium, lanthanum, magnesium and scandium oxides) and alkaline earth metal oxides was studied by the ESR method. The conclusion was made about the great reactivity of the peroxide structures O/sub 2//sup -/ in the oxidation catalysis in comparison to other formulas of chemisorption oxigen on oxides. The kinetic investigations are chemisorption oxigen on oxides. The kinetic investigations are carried out on the change of the concentration of paramagnetic particles O/sub 2/ during the catalysis. On the basis of the received data the conclusion is made about the reaction process of catalytic oxidation on rare and alkaline-earth oxides according to radical-chain mechanism with the formation of radical particles O/sub 2//sup -/, CO/sub 3//sup -/, SO/sub 4//sup -/, CO/sub 2//sup -/ as interediate products.

  3. A spectral study of the elementary step of proton transfer in heterogeneous acid catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Kazanskii, V B

    1977-09-01

    A spectral study of the elementary step of proton transfer in heterogeneous acid catalysis involved a determination of the potential curves of the OH bond in surface hydroxyl groups (e.g., those on silica, NaHY zeolite, or glass) of differing acidity from IR stretching frequency data in the overtone region; a calculation of the activation energies for proton transfer during acid catalysis from the changes in the curve forms after adsorption of various molecules (e.g., water, ammonia, benzene, toluene, xylenes, acetone, and cyclohexane); and a comparison of the IR predictions with quantum-chemical calculations of the potential curves. The results appear to furnish a new criterion for the coordinate of reactions involving Broensted sites: if the activation energy measured during actual catalysis is close to that calculated from the IR stretching data, the reaction proceeds by the stepwise mechanism of acid catalysis; but if these values differ greatly, the reaction involves a concerted mechanism (i.e., activation of the adsorbed molecule without involvement of OH groups). Tables, graphs, and 15 references.

  4. Numerical study on the stick-slip motion of contact line moving on heterogeneous surfaces

    Science.gov (United States)

    Liu, Ming; Chen, Xiao-Peng

    2017-08-01

    We present a numerical study of a moving contact line (CL) crossing the intersecting region of hydrophilic and hydrophobic patterns on a solid wall using lattice Boltzmann methods (LBMs). To capture the interface between the two phases properly, we applied a phase field model coupled with the LBM. The evolutions of the CL velocity, dynamic contact angle, and apparent contact angle are analyzed for the so-called "stick" and "slip" processes. In the two processes, the evolution of the quantities follows different rules shortly after the initial quick transition, which is probably caused by finite interfacial thickness or non-equilibrium effects. For the stick process, the CL is almost fixed and energy is extracted from the main flow to rebuild the meniscus' profile. The evolution of the meniscus is mainly governed by mass conservation. The CL is depinned after the apparent contact angle surpasses the dynamic one, which implies that the interfacial segment in the vicinity of contact line is bended. For the slip process, the quantities evolve with features of relaxation. In the microscopic scale, the velocity of the CL depends on the balance between unbalanced Young's capillary force and viscous drag. To predict the apparent contact angle evolution, a model following the dynamics of an overdamped spring-mass system is proposed. Our results also show that the capillary flows in a channel with heterogeneous wall can be described generally with the Poiseuille flow superimposed by the above transient one.

  5. A heterogeneous fleet vehicle routing model for solving the LPG distribution problem: A case study

    International Nuclear Information System (INIS)

    Onut, S; Kamber, M R; Altay, G

    2014-01-01

    Vehicle Routing Problem (VRP) is an important management problem in the field of distribution and logistics. In VRPs, routes from a distribution point to geographically distributed points are designed with minimum cost and considering customer demands. All points should be visited only once and by one vehicle in one route. Total demand in one route should not exceed the capacity of the vehicle that assigned to that route. VRPs are varied due to real life constraints related to vehicle types, number of depots, transportation conditions and time periods, etc. Heterogeneous fleet vehicle routing problem is a kind of VRP that vehicles have different capacity and costs. There are two types of vehicles in our problem. In this study, it is used the real world data and obtained from a company that operates in LPG sector in Turkey. An optimization model is established for planning daily routes and assigned vehicles. The model is solved by GAMS and optimal solution is found in a reasonable time

  6. A heterogeneous fleet vehicle routing model for solving the LPG distribution problem: A case study

    Science.gov (United States)

    Onut, S.; Kamber, M. R.; Altay, G.

    2014-03-01

    Vehicle Routing Problem (VRP) is an important management problem in the field of distribution and logistics. In VRPs, routes from a distribution point to geographically distributed points are designed with minimum cost and considering customer demands. All points should be visited only once and by one vehicle in one route. Total demand in one route should not exceed the capacity of the vehicle that assigned to that route. VRPs are varied due to real life constraints related to vehicle types, number of depots, transportation conditions and time periods, etc. Heterogeneous fleet vehicle routing problem is a kind of VRP that vehicles have different capacity and costs. There are two types of vehicles in our problem. In this study, it is used the real world data and obtained from a company that operates in LPG sector in Turkey. An optimization model is established for planning daily routes and assigned vehicles. The model is solved by GAMS and optimal solution is found in a reasonable time.

  7. Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families

    Directory of Open Access Journals (Sweden)

    Schuster Antje

    2005-01-01

    Full Text Available Abstract Background Asthma is a complex genetic disease with more than 20 genome-wide scans conducted so far. Regions on almost every chromosome have been linked to asthma and several genes have been associated. However, most of these associations are weak and are still awaiting replication. Methods In this study, we conducted a second-stage genome-wide scan with 408 microsatellite markers on 201 asthma-affected sib pair families and defined clinical subgroups to identify phenotype-genotype relations. Results The lowest P value for asthma in the total sample was 0.003 on chromosome 11, while several of the clinical subsets reached lower significance levels than in the overall sample. Suggestive evidence for linkage (p = 0.0007 was found for total IgE on chromosomes 1, 7 and again on chromosome 11, as well as for HDM asthma on chromosome 12. Weaker linkage signals could be found on chromosomes 4 and 5 for early onset and HDM, and, newly described, on chromosome 2 for severe asthma and on chromosome 9 for hay fever. Conclusions This phenotypic dissection underlines the importance of detailed clinical characterisations and the extreme genetic heterogeneity of asthma.

  8. Microwave frequency tuning in heterogeneous spin torque oscillator with perpendicular polarizer: A macrospin study

    Science.gov (United States)

    Bhoomeeswaran, H.; Vivek, T.; Sabareesan, P.

    2018-04-01

    In this article, we have theoretically devised a Spin Torque Nano Oscillator (STNO) with perpendicular polarizer using macro spin model. The devised spin valve structure is heterogeneous (i.e.) it is made of two different ferromagnetic materials [Co and its alloy CoFeB]. The dynamics of magnetization provoked by spin transfer torque is studied numerically by solving the famous Landau-Lifshitz-Gilbert-Slonczewski [LLGS] equation. The results are obtained for the perpendicular polarizer and for that particular out of plane orientation we vary the free layer angle from 10° to 90°. The obtained results are highly appealing, because frequency range is available in all the tilt angles of free layer and it is exceptionally tunable in all free layer tilt angles with zero applied field. Moreover, the utmost operating frequency of about 83.3 GHz and its corresponding power of 4.488 µW/mA2/GHz is acquired for the free layer tilt angle θ = 90° with the solid applied current density of 10 × 1010 A/m2. Also, our device emits high quality factor of about 396, which is remarkably desirable for making devices. These pioneering results provides a significant development for future spintronic based devices.

  9. A heterogeneous CPU+GPU Poisson solver for space charge calculations in beam dynamics studies

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Dawei; Rienen, Ursula van [University of Rostock, Institute of General Electrical Engineering (Germany)

    2016-07-01

    In beam dynamics studies in accelerator physics, space charge plays a central role in the low energy regime of an accelerator. Numerical space charge calculations are required, both, in the design phase and in the operation of the machines as well. Due to its efficiency, mostly the Particle-In-Cell (PIC) method is chosen for the space charge calculation. Then, the solution of Poisson's equation for the charge distribution in the rest frame is the most prominent part within the solution process. The Poisson solver directly affects the accuracy of the self-field applied on the charged particles when the equation of motion is solved in the laboratory frame. As the Poisson solver consumes the major part of the computing time in most simulations it has to be as fast as possible since it has to be carried out once per time step. In this work, we demonstrate a novel heterogeneous CPU+GPU routine for the Poisson solver. The novel solver also benefits from our new research results on the utilization of a discrete cosine transform within the classical Hockney and Eastwood's convolution routine.

  10. Reliability of MODIS Evapotranspiration Products for Heterogeneous Dry Forest: A Study Case of Caatinga

    Directory of Open Access Journals (Sweden)

    Rodrigo de Queiroga Miranda

    2017-01-01

    Full Text Available Evapotranspiration (ET is normally considered as the sum of all water that evaporates from the soil and transpires from plants. However, accurately estimating ET from complex landscapes can be difficult because of its high spatial heterogeneity and diversity of driver factors, which make extrapolation of data from a point to a larger area quite inaccurate. In this paper, we hypothesize that MODIS products can be of use to estimate ET in areas of Caatinga vegetation, the hydrology of which has not been adequately studied. The experiment was conducted in a preserved level area of Caatinga in which meteorological and water flux measures were taken throughout 2012 by eddy covariance. Evapotranspiration estimates from eddy covariance were compared with remotely sensed evapotranspiration estimates from MOD16A2 and SAFER products. Correlations were performed at monthly, 8-day, and daily scales; and produced r2 values of monthly scale = 0.92, 8-day scale = 0.88, and daily scale = 0.85 for the SAFER algorithm. Monthly MOD16A2 data produced a value of r2=0.82, and they may be useful because they are free, downloadable, and easy to use by researchers and governments.

  11. Study of Operating Parameters for Accelerated Anode Degradation in SOFCs

    DEFF Research Database (Denmark)

    Ploner, Alexandra; Hagen, Anke; Hauch, Anne

    2017-01-01

    Solid oxide fuel cell (SOFC) applications require lifetimes of several years on the system level. A big challenge is to demonstrate such exceptionally long lifetimes in ongoing R&D projects. Accelerated or compressed testing are alternative methods to obtain this. Activities in this area have been...... carried out without arriving at a generally accepted methodology. This is mainly due to the complexity of degradation mechanisms on the single SOFC components as function of operating parameters. In this study, we present a detailed analysis of approx. 180 durability tests regarding degradation of single...... SOFC components as function of operating conditions. Electrochemical impedance data were collected on the fresh and long-term tested SOFCs and used to de-convolute the individual losses of single SOFC cell components – electrolyte, cathode and anode. The main findings include a time-dependent effect...

  12. Does Cigarette Smoking Affect Seminal Fluid Parameters? A Comparative Study

    Directory of Open Access Journals (Sweden)

    Zakarya Bani Meri

    2013-01-01

    Full Text Available Objective: To study the effect of cigarette smoking on seminal fluid parameters, namely; volume, sperm concentration, and motility, as well as morphology, leukocyte infiltration, among males complaining of infertility.Methods: Between August 2010 and July 2011, seminal fluid analysis was done for 1438 males who are partners of couples who visited the infertility clinic at Prince Rashid Ben Al Hassan Hospital (PRH for infertility. The men who fit the inclusion criteria (n=960 were classified into two groups: group a (non-smokers; n=564 and group B (smokers; n=396, which represents 41.25% of the study group. Seminal fluid was collected using masturbation after 3-5 days of abstinence then analyzed for volume, sperm count, sperm concentration, motility and morphology. In order to analyze whether the number of cigarettes smoked per day has an effect on the spermatogram; the smoking men were divided into two subgroups: the heavy smokers (n=266 and non-heavy smokers (n=130.Results: A total of 960 adult males were enrolled. Their age ranged between 21 and 76 years, 564 were non-smokers with mean age of 36. 45±6.27 (Mean±SD. Three-hundred-and-ninety-six were smokers with a mean age of 34.35±4.25 (Mean±SD. There was a significant effect of smoking on the motility of sperms and the ratios of abnormality (p<0.005. Concentration appeared not to be affected by smoking. Furthermore, the group of heavy smokers were found to have lower sperm concentrations and a higher percentage of abnormal sperms compared to the non-heavy smokers.Conclusion: Cigarette smoking has a deleterious effect on some of the seminal fluid parameters (motility, morphology and leukocyte count which in turn may result in male subfertility.

  13. Heterogeneity of Human Research Ethics Committees and Research Governance Offices across Australia: An observational study

    Directory of Open Access Journals (Sweden)

    Elisabeth De Smit

    2016-02-01

    Full Text Available Background Conducting ethically grounded research is a fundamental facet of all investigations. Nevertheless, the administrative burdens of current ethics review are substantial, and calls have been made for a reduction in research waste. Aims To describe the heterogeneity in administration and documentation required by Human Research Ethics Committees (HRECs and Research Governance Offices (RGOs across Australia. Methods In establishing a nationwide study to investigate the molecular aetiology of Giant Cell Arteritis (GCA, for which archived pathological specimens from around Australia are being recruited, we identified variation across separate HREC and RGO requirements. Submission paperwork and correspondence from each collaborating site and its representative office for research were reviewed. This data was interrogated to evaluate differences in current guidelines. Results Twenty-five pathology departments across seven Australian States collaborated in this study. All states, except Victoria, employed a single ethics review model. There was discrepancy amongst HRECs as to which application process applied to our study: seven requested completion of a “National Ethics Application Form” and three a “Low Negligible Risk” form. Noticeable differences in guidelines included whether electronic submission was sufficient. There was variability in the total number of documents submitted (range five to 22 and panel review turnaround time (range nine to 136 days. Conclusion We demonstrate the challenges and illustrate the heavy workload involved in receiving widespread ethics and governance approval across Australia. We highlight the need to simplify, homogenise, and nationalise human ethics for non-clinical trial studies. Reducing unnecessary administration will enable investigators to achieve research aims more efficiently

  14. Damping parameter study of a perforated plate with bias flow

    Science.gov (United States)

    Mazdeh, Alireza

    role of LES for research studies concerned with damping properties of liners is limited to validation of other empirical or theoretical approaches. This research has shown that LES can go beyond that and can be used for performing parametric studies to characterize the sensitivity of acoustic properties of multi--perforated liners to the changes in the geometry and flow conditions and be used as a tool to design acoustic liners. The conducted research provides an insightful understanding about the contribution of different flow and geometry parameters such as perforated plate thickness, aperture radius, porosity factors and bias flow velocity. While the study agrees with previous observations obtained by analytical or experimental methods, it also quantifies the impact from these parameters on the acoustic impedance of perforated plate, a key parameter to determine the acoustic performance of any system. The conducted study has also explored the limitations and capabilities of commercial tool when are applied for performing simulation studies on damping properties of liners. The overall agreement between LES results and previous studies proves that commercial tools can be effectively used for these applications under certain conditions.

  15. Computational studies of global nuclear energy development under the assumption of the world's heterogeneous development

    International Nuclear Information System (INIS)

    Egorov, A.F.; Korobejnikov, V.V.; Poplavskaya, E.V.; Fesenko, G.A.

    2013-01-01

    Authors study the mathematical model of Global nuclear energy development until the end of this century. For comparative scenarios analysis of transition to sustainable nuclear energy systems, the models of heterogeneous world with an allowance for specific national development are under investigation [ru

  16. Estimates of between-study heterogeneity for 705 meta-analyses reported in Psychological Bulletin from 1990-2013

    NARCIS (Netherlands)

    van Erp, S.J.; Verhagen, Josine; Grasman, Raoul P P P; Wagenmakers, Eric-Jan

    2017-01-01

    We present a data set containing 705 between-study heterogeneity estimates τ2 as reported in 61 articles published in Psychological Bulletin from 1990-2013. The data set also includes information about the number and type of effect sizes, the Q- and I2-statistics, and publication bias. The data set

  17. Estimates of Between-Study Heterogeneity for 705 Meta-Analyses Reported in Psychological Bulletin From 1990–2013

    NARCIS (Netherlands)

    van Erp, S.; Verhagen, J.; Grasman, R.P.P.P.; Wagenmakers, E.-J.

    2017-01-01

    We present a data set containing 705 between-study heterogeneity estimates τ2 as reported in 61 articles published in Psychological Bulletin from 1990–2013. The data set also includes information about the number and type of effect sizes, the Q- and I2-statistics, and publication bias. The data set

  18. Intra-voxel heterogeneity influences the dose prescription for dose-painting with radiotherapy: a modelling study

    NARCIS (Netherlands)

    Petit, S.F.; Dekker, A.L.A.J.; Seigneuric, R.; Murrer, L.H.P.; Riel, van N.A.W.; Nordsmark, M.; Overgaard, J.; Lambin, Ph.; Wouters, B.G.

    2009-01-01

    The purpose of this study was to increase the potential of dose redistribution by incorporating estimates of oxygen heterogeneity within imaging voxels for optimal dose determination. Cellular oxygen tension (pO2) distributions were estimated for imaging-size-based voxels by solving oxygen

  19. BIOTIC (FORAMINIFERA AND THECAMOEBIANS AND ABIOTIC PARAMETERS AS PROXIES FOR IDENTIFICATION OF THE ENVIRONMENTAL HETEROGENEITY IN CAETÉ RIVER ESTUARY, AMAZON COAST, BRAZIL

    Directory of Open Access Journals (Sweden)

    Lazaro Luiz Mattos Laut1

    2016-01-01

    Full Text Available Foraminifera and thecamoebians assemblages were analyzed at Caeté River Estuary in order to identify saline gradients and intensity of human impacts. In the study area, 29 species of foraminifera typically from intertidal environments and 11 species of thecamoebians were identified. The microfaunal assemblages were characterized by low diversity, averaging 1.9 at the mouth and 0.5 near Bragança City. These values are common in transitional coastal environments along de Brazilian Coast. Statistical analysis, based on the relative abundance of species, did not reveal the presence of an estuarine gradient, which was corroborated by the physical and chemical parameters measured in the field. An increasing of sedimentary fine fraction and organic matter occurs in the intermediate region of the estuary, indicating attenuation of the stream influence. The calcareous foraminifera species were associated with high salinity, temperature and pH values. The agglutinated species were associated with muddy sediment, total organic matter and lower salinity. Four environmental compartments were identified based on biotic and abiotic analysis, but they do not represent the classic estuarine gradient, instead, they represent the differences in the freshwater supply and mangrove distance.

  20. Ultrasonography as a prognostic and objective parameter in Achilles tendinopathy: A prospective observational study

    International Nuclear Information System (INIS)

    Bakkegaard, Mads; Johannsen, Finn E.; Højgaard, Betina; Langberg, Henning

    2015-01-01

    Objectives: To study prospectively whether structural changes determined by ultrasound scanning (US) can be used as prognostic markers for outcome in patients with symptomatic Achilles tendinopathy (AT) and to investigate whether there exists an association between US findings and pain measured by visual analog scale (VAS) and a general assessment score (GA). Methods: 92 consecutive patients with AT symptoms were recruited from two outpatient clinics in rheumatology. The patients underwent a conservative treatment protocol consisting of reduced activities, controlled rehabilitation including eccentric exercises of the calf muscles and if needed supplemented with corticosteroid injections. The patients were examined clinically and by US (tendon thickness, hyper- and hypoechogenicity, calcification, bursitis, calcaneusspure, tenosynovitis, gray scale and color Doppler focusing on increased flow intra- or peritendinous). The clinical and US examination were performed at entry, 1, 2, 3 and at 6 month. Results: 42 women and 50 men were included (mean age of 47 years). They had symptoms for more than 13 months and a symptomatic Achilles tendon mean thickness of 7.4 ± 2.3 mm. Heterogeneity at the initial examination was found to be a prognostic marker for the clinical outcome. Tendon thickness, hypoechogenicity and increased flow at any time point were significantly correlated to pain at function, palpatory pain and morning pain at the same time points. A reduction in tendon thickness was statistically associated with a decrease in palpatory pain. Conclusion: Heterogeneity is a prognostic marker in AT. Tendon thickness, hypoechogenicity and increased Doppler activity can be used as objective outcome parameters for the treatment effect of AT

  1. Ultrasonography as a prognostic and objective parameter in Achilles tendinopathy: A prospective observational study

    Energy Technology Data Exchange (ETDEWEB)

    Bakkegaard, Mads, E-mail: mbakkegaard@hotmail.com [Department of Rheumatology, Holbæk Hospital, Smedelundsgade 60, 4300 Holbæk (Denmark); Johannsen, Finn E., E-mail: f.e.johannsen@dadlnet.dk [Private Department of Rheumatology, Furesø-reumatologerne, Farum and ISMC, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, 2. Tværvej, Indgang 8, 1. sal, 2400 København NV (Denmark); Højgaard, Betina, E-mail: beho@kora.dk [Danish Institute for Local and Regional Government Research, Købmagergade 22, 1150 København K (Denmark); Langberg, Henning, E-mail: henninglangberg@gmail.com [Institute of Social Medicine, Department of Public Health and Centre for Healthy Ageing, Faculty of Heath Sciences, University of Copenhagen, Øster Farimagsgade 5, bygn. 24, postboks 2099, 1014 København (Denmark)

    2015-03-15

    Objectives: To study prospectively whether structural changes determined by ultrasound scanning (US) can be used as prognostic markers for outcome in patients with symptomatic Achilles tendinopathy (AT) and to investigate whether there exists an association between US findings and pain measured by visual analog scale (VAS) and a general assessment score (GA). Methods: 92 consecutive patients with AT symptoms were recruited from two outpatient clinics in rheumatology. The patients underwent a conservative treatment protocol consisting of reduced activities, controlled rehabilitation including eccentric exercises of the calf muscles and if needed supplemented with corticosteroid injections. The patients were examined clinically and by US (tendon thickness, hyper- and hypoechogenicity, calcification, bursitis, calcaneusspure, tenosynovitis, gray scale and color Doppler focusing on increased flow intra- or peritendinous). The clinical and US examination were performed at entry, 1, 2, 3 and at 6 month. Results: 42 women and 50 men were included (mean age of 47 years). They had symptoms for more than 13 months and a symptomatic Achilles tendon mean thickness of 7.4 ± 2.3 mm. Heterogeneity at the initial examination was found to be a prognostic marker for the clinical outcome. Tendon thickness, hypoechogenicity and increased flow at any time point were significantly correlated to pain at function, palpatory pain and morning pain at the same time points. A reduction in tendon thickness was statistically associated with a decrease in palpatory pain. Conclusion: Heterogeneity is a prognostic marker in AT. Tendon thickness, hypoechogenicity and increased Doppler activity can be used as objective outcome parameters for the treatment effect of AT.

  2. Heterogeneity of uridine incorporation along the rabbit nephron. I. Autoradiographic study

    International Nuclear Information System (INIS)

    Vandewalle, A.; Farman, N.; Cluzeaud, F.; Bonvalet, J.P.

    1984-01-01

    An autoradiographic study of uridine labeling in tubular segments microdissected from the rabbit kidney is presented. Kidney pyramids were incubated for 60 min with low (66 nM) and high (66μM) [ 3 H]-uridine concentration. At the two concentrations studied the labeling was almost exclusively nuclear in all segments studied. At the low concentration, labeling predominated in the macula densa (MD = 63.88 +/- 6.15 silver grains/100 μm 2 , n = 11), cortical ascending limb (CAL = 19.65 +/- 1.65, n = 15), and initial distal tubule (DCT/sub a/ = 24.31 +/- 2.70, n = 6). It was minimal in the proximal tubule (PCT 2 = 9.14 +/- 1.61, n = 16) and in the cortical (CCT = 5.23 +/- 0.75, n = 18) and medullary (MCT = 5.52 +/- 1.10, n = 12) collecting ducts. At a high concentration, the profile of labeling was roughly similar except for a relative increase in labeling much more pronounced in collecting ducts (CCT = +373, MCT = +323%) than in the other structures (MD = -14, CAL = +66, DCT/sub a/ = +49, PCT = +9%). Pulse-chase experiments do not show evidence for differences in turnover or degradation rates of RNA between segments, at least in the PCT and the connecting part of the CCT. Analysis of the results at low and high concentration suggests that the observed heterogeneity in uridine labeling depends on both variable endogenous nucleoside pools and different rates of uridine incorporation into RNA from one segment to another

  3. Heterogeneity of uridine incorporation along the rabbit nephron. I. Autoradiographic study

    Energy Technology Data Exchange (ETDEWEB)

    Vandewalle, A.; Farman, N.; Cluzeaud, F.; Bonvalet, J.P.

    1984-04-01

    An autoradiographic study of uridine labeling in tubular segments microdissected from the rabbit kidney is presented. Kidney pyramids were incubated for 60 min with low (66 nM) and high (66..mu..M) (/sup 3/H)-uridine concentration. At the two concentrations studied the labeling was almost exclusively nuclear in all segments studied. At the low concentration, labeling predominated in the macula densa (MD = 63.88 +/- 6.15 silver grains/100 ..mu..m/sup 2/, n = 11), cortical ascending limb (CAL = 19.65 +/- 1.65, n = 15), and initial distal tubule (DCT/sub a/ = 24.31 +/- 2.70, n = 6). It was minimal in the proximal tubule (PCT/sub 2/ = 9.14 +/- 1.61, n = 16) and in the cortical (CCT = 5.23 +/- 0.75, n = 18) and medullary (MCT = 5.52 +/- 1.10, n = 12) collecting ducts. At a high concentration, the profile of labeling was roughly similar except for a relative increase in labeling much more pronounced in collecting ducts (CCT = +373, MCT = +323%) than in the other structures (MD = -14, CAL = +66, DCT/sub a/ = +49, PCT = +9%). Pulse-chase experiments do not show evidence for differences in turnover or degradation rates of RNA between segments, at least in the PCT and the connecting part of the CCT. Analysis of the results at low and high concentration suggests that the observed heterogeneity in uridine labeling depends on both variable endogenous nucleoside pools and different rates of uridine incorporation into RNA from one segment to another.

  4. THE STUDY OF THE MAIN PARAMETERS QUALITY OF BUFFALO MILK

    Directory of Open Access Journals (Sweden)

    AURELIA PECE

    2010-02-01

    Full Text Available Researches were conducted on a biologic material, a buffalo livestock, in different lactating stages and their physico-chemical parameters were determined: fat, protein, lactose, unfat dry substance, density, pH, temperature. Regarding the variation of these components, researches conducted emphasized differences determined by those conditions specific to reference seasons. Individual analysis on the buffalo livestock in the study, emphasized significant differences: fat 8.59-9.36%, protein 5.16-5.31% respective of lactation. Microbiologic determinations mainly envisioned: the number of somatic cells (NSC, number of total germs (NTG Positive Coagulanzo Stafilococii, Listeria, Salmonella, determinations which lay at the basis of the assessment of buffalo milk quality. The positive Coagulanzo stafilococus was absent, excepting sample number 15 (2 germs/ml and sample number 22 (4 germs/ml; Salmonella was absent. Regarding the total number of germs: values between 1.0-1.8 germs/ml were obtained. The detection of this microbiologic parameter in the composition of buffalo milk provides information regarding the hygienic conditions of their production and handling. Correlations between the number of somatic cells, milk production and composition are employed in dairy buffalo farms, in order to assess losses caused by mastitis and the implementing of certain measures for the control of these diseases. On the other hand, correlations between the number of somatic cells and milk composition prove useful in establishing milk processing behaviour, as the practice of setting milk-raw matter prices according to the number of somatic cells in the milk is becoming increasingly more frequent in developed countries.

  5. Hydrogen chloride heterogeneous chemistry on frozen water particles in subsonic aircraft plume. Laboratory studies and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Persiantseva, N.V.; Popovitcheva, O.B.; Rakhimova, T.V. [Moscow State Univ. (Russian Federation)

    1997-12-31

    Heterogeneous chemistry of HCl, as a main reservoir of chlorine content gases, has been considered after plume cooling and ice particle formation. The HCl, HNO{sub 3}, N{sub 2}O{sub 5} uptake efficiencies by frozen water were obtained in a Knudsen-cell flow reactor at the subsonic cruise conditions. The formation of ice particles in the plume of subsonic aircraft is simulated to describe the kinetics of gaseous HCl loss due to heterogeneous processes. It is shown that the HCl uptake by frozen water particles may play an important role in the gaseous HCl depletion in the aircraft plume. (author) 14 refs.

  6. Hydrogen chloride heterogeneous chemistry on frozen water particles in subsonic aircraft plume. Laboratory studies and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Persiantseva, N V; Popovitcheva, O B; Rakhimova, T V [Moscow State Univ. (Russian Federation)

    1998-12-31

    Heterogeneous chemistry of HCl, as a main reservoir of chlorine content gases, has been considered after plume cooling and ice particle formation. The HCl, HNO{sub 3}, N{sub 2}O{sub 5} uptake efficiencies by frozen water were obtained in a Knudsen-cell flow reactor at the subsonic cruise conditions. The formation of ice particles in the plume of subsonic aircraft is simulated to describe the kinetics of gaseous HCl loss due to heterogeneous processes. It is shown that the HCl uptake by frozen water particles may play an important role in the gaseous HCl depletion in the aircraft plume. (author) 14 refs.

  7. Workload Balancing on Heterogeneous Systems: A Case Study of Sparse Grid Interpolation

    KAUST Repository

    Muraraşu, Alin

    2012-01-01

    Multi-core parallelism and accelerators are becoming common features of today’s computer systems, as they allow for computational power without sacrificing energy efficiency. Due to heterogeneity, tuning for each type of compute unit and adequate load balancing is essential. This paper proposes static and dynamic solutions for load balancing in the context of an application for visualizing high-dimensional simulation data. The application relies on the sparse grid technique for data compression. Its performance critical part is the interpolation routine used for decompression. Results show that our load balancing scheme allows for an efficient acceleration of interpolation on heterogeneous systems containing multi-core CPUs and GPUs.

  8. Lateral heterogeneity and vertical stratification of cratonic lithospheric keels: a case study of the Siberian craton

    DEFF Research Database (Denmark)

    Artemieva, Irina; Cherepanova, Yulia; Herceg, Matija

    2014-01-01

    by regional xenolith P-T arrays,lithosphere density heterogeneity as constrained by free-board and satellite gravity data, and the non-thermalpart of upper mantle seismic velocity heterogeneity based on joint analysis of thermal and seismic tomography data.Density structure of the cratonic lithosphere...... and strongly depleted lithospheric mantle of the Archean nuclei, particularly below the Anabar shield.Since we cannot identify the depth distribution of density anomalies, we complement the approach by seismicdata. An analysis of temperature-corrected seismic velocity structure indicates strong vertical...

  9. studies on the correlation of some aggregate parameters in the ...

    African Journals Online (AJOL)

    BARTH EKWUEME

    simulations for problem solving and forecasting environmental conditions .... METHODS. Parameters: The water quality parameters examined were, Turbidity, Total Dissolved Solids (TDS),. Chemical Oxygen Demand (COD), 5-day Biochemical. Oxygen Demand ..... Vogel's Textbook of Quantitative. Chemical Analysis 6th ed ...

  10. Systematic parameter study of dynamo bifurcations in geodynamo simulations

    Science.gov (United States)

    Petitdemange, Ludovic

    2018-04-01

    We investigate the nature of the dynamo bifurcation in a configuration applicable to the Earth's liquid outer core, i.e. in a rotating spherical shell with thermally driven motions with no-slip boundaries. Unlike in previous studies on dynamo bifurcations, the control parameters have been varied significantly in order to deduce general tendencies. Numerical studies on the stability domain of dipolar magnetic fields found a dichotomy between non-reversing dipole-dominated dynamos and the reversing non-dipole-dominated multipolar solutions. We show that, by considering weak initial fields, the above transition disappears and is replaced by a region of bistability for which dipolar and multipolar dynamos coexist. Such a result was also observed in models with free-slip boundaries in which the geostrophic zonal flow can develop and participate to the dynamo mechanism for non-dipolar fields. We show that a similar process develops in no-slip models when viscous effects are reduced sufficiently. The following three regimes are distinguished: (i) Close to the onset of convection (Rac) with only the most critical convective mode (wave number) being present, dynamos set in supercritically in the Ekman number regime explored here and are dipole-dominated. Larger critical magnetic Reynolds numbers indicate that they are particularly inefficient. (ii) in the range 3 10) , the relative importance of zonal flows increases with Ra in non-magnetic models. The field topology depends on the magnitude of the initial magnetic field. The dipolar branch has a subcritical behavior whereas the multipolar branch has a supercritical behavior. By approaching more realistic parameters, the extension of this bistable regime increases. A hysteretic behavior questions the common interpretation for geomagnetic reversals. Far above the dynamo threshold (by increasing the magnetic Prandtl number), Lorentz forces contribute to the first order force balance, as predicted for planetary dynamos. When

  11. A case study of Markdale High School's implementation of heterogeneously-grouped classes in English, mathematics, science, and social studies

    Science.gov (United States)

    Pierre-Louis, Fred

    The purpose of this study was to describe Markdale High School's change from separate college preparatory and general level classes to heterogeneously-grouped classes in English, mathematics, science, and social studies, with particular emphasis on the principal's leadership style, change process, and teacher concerns (Hall & Hord, 2006) experienced during this effort. The researcher used Hall and Hord's (2006) Concern-Based Adoption Model (CBAM) as a conceptual framework. Specifically, the researcher applied three elements of the CBAM model: (a) the Twelve Principles of Change, (b) the Change Facilitator Styles, and (c) the Stages of Concerns. Hall and Hord's framework served as a lens through which the researcher analyzed all data. The researcher used a mixed-method (qualitative and quantitative) approach to answer the four research questions. The participants completed three instruments: (a) the Stages of Concern Questionnaire (SoCQ), (b) the Principles of Change Survey, and (c) the Facilitator Style Survey. All three instruments were self-report, paper-pencil surveys. The sample included 72 faculty members who experienced the change over the past three years. Findings from the three data sources and the school principal's comments during debriefing are indicated for each research question and reported by unit of analysis. Respective to the research questions, the researcher concluded that: (1) Markdale High School accomplished the change by implementing both structural and instructional changes supporting to the change to heterogeneous grouping; (2) even though teachers had divergent opinions on the school principal's facilitation style, the principal thought of himself as an incrementalist and a practitioner of differentiated facilitation styles; (3) while half of the faculty felt that they received formal training on heterogeneous grouping, (4) half felt that they did not have a choice in the decision-making process as it occurred with college preparatory and

  12. Study of Parameters that Determine Railway Line Capacity

    Directory of Open Access Journals (Sweden)

    Josip Kukec

    2005-07-01

    Full Text Available In this work the study focuses on:- determining the elements required to determine the locationfor the installation of the main signals,- calculated block lengths, and- calculations of optimal head ways, that have not been studiedin detail although they deserve special attention due totheir impact.Generally speaking, the signals are installed in compliancewith the local circumstances, i. e. according to the technicaland technological characteristics and conditions determinedby the traffic places of work they protect.The distribution and length of the blocks depend on: therailway line and its exploitation characteristics, structure andtype of trains that run on the railway line, traffic organisationand signalisation system, as well as technical and exploitationcharacte1istics of the traction vehicles and the rolling stock.What has to be considered is that the minimum section lengthcannot be shorter than the length of the braking distance, i. e.the length of the longest train which runs on the respective railwayline.The study of these parameters is supplemented by the calculationof the reduction in throughput capacity depending on thelack of uniformity in the operation of trains, which, in order tomaintain the design quality of the transportation se1vice, and inthe activities of establishing and implementing the business policyshouldn't be left out nor bypassed.

  13. Evaluation of intratumoral HER-2 heterogeneity by fluorescence in situ hybridization in invasive breast cancer: a single institution study.

    Science.gov (United States)

    Lee, Sarah; Jung, Woohee; Hong, Soon-Won; Koo, Ja Seung

    2011-08-01

    This study aimed to determine the incidence and characteristics of HER-2 gene heterogeneity in invasive breast cancer in a single institution. Included were 971 cases of primary invasive breast cancer diagnosed between 2008 and 2010. Fluorescence in situ hybridization (FISH) image files were retrospectively reviewed and HER-2 gene heterogeneity was defined as more than 5% but less than 50% of analyzed invasive tumor cells with a HER-2/Chr17 ratio higher than 2.2, according to the College of American Pathologists guidelines. HER-2 gene heterogeneity was identified in 24 (2.5%) cases. The mean proportion of invasive tumor cells with a HER-2/chromosome 17 ratio higher than 2.2 was 11.6% (range: 5%-25%). Of 24 cases, HER-2 gene status was not amplified in 8, showed borderline amplification in 2, and amplification in 14. All HER-2 amplification cases were low-grade. In conclusion, HER-2 gene heterogeneity of invasive breast cancer is identified in routine FISH examination. This may affect the results of HER-2 gene amplification status in FISH studies.

  14. Effect of Tissue Heterogeneity on the Transmembrane Potential of Type-1 Spiral Ganglion Neurons: A Simulation Study.

    Science.gov (United States)

    Sriperumbudur, Kiran Kumar; Pau, Hans Wilhelm; van Rienen, Ursula

    2018-03-01

    Electric stimulation of the auditory nerve by cochlear implants has been a successful clinical intervention to treat the sensory neural deafness. In this pathological condition of the cochlea, type-1 spiral ganglion neurons in Rosenthal's canal play a vital role in the action potential initiation. Various morphological studies of the human temporal bones suggest that the spiral ganglion neurons are surrounded by heterogeneous structures formed by a variety of cells and tissues. However, the existing simulation models have not considered the tissue heterogeneity in the Rosenthal's canal while studying the electric field interaction with spiral ganglion neurons. Unlike the existing models, we have implemented the tissue heterogeneity in the Rosenthal's canal using a computationally inexpensive image based method in a two-dimensional finite element model. Our simulation results suggest that the spatial heterogeneity of surrounding tissues influences the electric field distribution in the Rosenthal's canal, and thereby alters the transmembrane potential of the spiral ganglion neurons. In addition to the academic interest, these results are especially useful to understand how the latest tissue regeneration methods such as gene therapy and drug-induced resprouting of peripheral axons, which probably modify the density of the tissues in the Rosenthal's canal, affect the cochlear implant functionality.

  15. Physical heterogeneity and aquatic community function in river networks: A case study from the Kanawha River Basin, USA

    Science.gov (United States)

    Thoms, M. C.; Delong, M. D.; Flotemersch, J. E.; Collins, S. E.

    2017-08-01

    The geomorphological character of a river network provides the template upon which evolution acts to create unique biological communities. Deciphering commonly observed patterns and processes within riverine landscapes resulting from the interplay between physical and biological components is a central tenet for the interdisciplinary field of river science. Relationships between the physical heterogeneity and food web character of functional process zones (FPZs) - large tracts of river with a similar geomorphic character -in the Kanawha River (West Virginia, USA) are examined in this study. Food web character was measured as food chain length (FCL), which reflects ecological community structure and ecosystem function. Our results show that the same basal resources were present throughout the Kanawha River but that their assimilation into the aquatic food web by primary consumers differed between FPZs. Differences in the trophic position of higher consumers (fish) were also recorded between FPZs. Overall, the morphological heterogeneity and heterogeneity of the river bed sediment of FPZs were significantly correlated with FCL. Specifically, FCL increases with greater FPZ physical heterogeneity. The result of this study does not support the current paradigm that ecosystem size is the primary determinant of food web character in river ecosystems.

  16. Intermediate-Scale Experimental Study to Improve Fundamental Understanding of Attenuation Capacity for Leaking CO2 in Heterogeneous Shallow Aquifers

    Science.gov (United States)

    Plampin, Michael R.; Porter, Mark L.; Pawar, Rajesh J.; Illangasekare, Tissa H.

    2017-12-01

    To assess the risks of Geologic Carbon Sequestration (GCS), it is crucial to understand the fundamental physicochemical processes that may occur if and when stored CO2 leaks upward from a deep storage reservoir into the shallow subsurface. Intermediate-scale experiments allow for improved understanding of the multiphase evolution processes that control CO2 migration behavior in the subsurface, because the boundary conditions, initial conditions, and porous media parameters can be better controlled and monitored in the laboratory than in field settings. For this study, a large experimental test bed was designed to mimic a cross section of a shallow aquifer with layered geologic heterogeneity. As water with aqueous CO2 was injected into the system to mimic a CO2-charged water leakage scenario, the spatiotemporal evolution of the multiphase CO2 plume was monitored. Similar experiments were performed with two different sand combinations to assess the relative effects of different types of geologic facies transitions on the CO2 evolution processes. Significant CO2 attenuation was observed in both scenarios, but by fundamentally different mechanisms. When the porous media layers had very different permeabilities, attenuation was caused by local accumulation (structural trapping) and slow redissolution of gas phase CO2. When the permeability difference between the layers was relatively small, on the other hand, gas phase continually evolved over widespread areas near the leading edge of the aqueous plume, which also attenuated CO2 migration. This improved process understanding will aid in the development of models that could be used for effective risk assessment and monitoring programs for GCS projects.

  17. Indoor air purification using heterogeneous photocatalytic oxidation. Part I: Experimental study

    NARCIS (Netherlands)

    Yu, Q.; Brouwers, H.J.H.

    2009-01-01

    Heterogeneous photocatalytic oxidation (PCO) has shown to be a promising air purifying technology in outdoor conditions using TiO2 as photocatalyst activated with UV light. Also to indoor air quality more and more attention is paid because of the very important role it plays on human health, and it

  18. Study to optimize a disposal tunnel layout taking into account heterogeneous characteristics of the geological environment

    International Nuclear Information System (INIS)

    Suyama, Yasuhiro; Toida, Masaru; Yanagizawa, Koichi

    2007-01-01

    The geological environment has spatially heterogeneous characteristics with varied host rock types, fractures and so on. In this case the generic disposal tunnel layout, which has been designed by JNC, is not the most suitable for HLW disposal in Japan. The existence of spatially heterogeneous characteristics means that in the repository region there exist sub-regions that are more favorable from the perspective of long-term safety and ones that are less favorable. In order that the spatially heterogeneous environment itself may be utilized most effectively as an NBS, an alternative design of disposal tunnel layout is required. Focusing on the geological environment with spatially heterogeneous characteristics, the authors have developed an alternative design of disposal tunnel layout. The alternative design adopts an optimization approach using a 'variable disposal tunnel layout'. The optimization approach minimizes the number of locations where major water conducting fractures are intersected, and maximizes the number of emplacement locations for waste packages. This paper will outline the variable disposal tunnel layout and its applicability. (author)

  19. Preliminary study of tumor heterogeneity in imaging predicts two year survival in pancreatic cancer patients.

    Directory of Open Access Journals (Sweden)

    Jayasree Chakraborty

    Full Text Available Pancreatic ductal adenocarcinoma (PDAC is one of the most lethal cancers in the United States with a five-year survival rate of 7.2% for all stages. Although surgical resection is the only curative treatment, currently we are unable to differentiate between resectable patients with occult metastatic disease from those with potentially curable disease. Identification of patients with poor prognosis via early classification would help in initial management including the use of neoadjuvant chemotherapy or radiation, or in the choice of postoperative adjuvant therapy. PDAC ranges in appearance from homogeneously isoattenuating masses to heterogeneously hypovascular tumors on CT images; hence, we hypothesize that heterogeneity reflects underlying differences at the histologic or genetic level and will therefore correlate with patient outcome. We quantify heterogeneity of PDAC with texture analysis to predict 2-year survival. Using fuzzy minimum-redundancy maximum-relevance feature selection and a naive Bayes classifier, the proposed features achieve an area under receiver operating characteristic curve (AUC of 0.90 and accuracy (Ac of 82.86% with the leave-one-image-out technique and an AUC of 0.80 and Ac of 75.0% with three-fold cross-validation. We conclude that texture analysis can be used to quantify heterogeneity in CT images to accurately predict 2-year survival in patients with pancreatic cancer. From these data, we infer differences in the biological evolution of pancreatic cancer subtypes measurable in imaging and identify opportunities for optimized patient selection for therapy.

  20. Heterogeneity of accelerated photooxidation in commodity polymers stabilized by HAS: ESRI, IR, and MH study

    Czech Academy of Sciences Publication Activity Database

    Pilař, Jan; Michálková, Danuše; Šlouf, Miroslav; Vacková, Taťana; Dybal, Jiří

    2014-01-01

    Roč. 103, May (2014), s. 11-25 ISSN 0141-3910 R&D Projects: GA ČR GA202/09/2078 Institutional support: RVO:61389013 Keywords : hindered amine stabilizers * heterogeneity of photooxidation * electron spin resonance imaging Subject RIV: BO - Biophysics Impact factor: 3.163, year: 2014

  1. A model-based approach to studying changes in compositional heterogeneity

    NARCIS (Netherlands)

    Baeten, L.; Warton, D.; Calster, van H.; Frenne, De P.; Verstraeten, G.; Bonte, D.; Bernhardt-Romermann, M.; Cornelis, R.; Decocq, G.; Eriksson, O.; Hommel, P.W.F.M.

    2014-01-01

    1. Non-random species loss and gain in local communities change the compositional heterogeneity between communities over time, which is traditionally quantified with dissimilarity-based approaches. Yet, dissimilarities summarize the multivariate species data into a univariate index and obscure the

  2. Preliminary study of tumor heterogeneity in imaging predicts two year survival in pancreatic cancer patients.

    Science.gov (United States)

    Chakraborty, Jayasree; Langdon-Embry, Liana; Cunanan, Kristen M; Escalon, Joanna G; Allen, Peter J; Lowery, Maeve A; O'Reilly, Eileen M; Gönen, Mithat; Do, Richard G; Simpson, Amber L

    2017-01-01

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in the United States with a five-year survival rate of 7.2% for all stages. Although surgical resection is the only curative treatment, currently we are unable to differentiate between resectable patients with occult metastatic disease from those with potentially curable disease. Identification of patients with poor prognosis via early classification would help in initial management including the use of neoadjuvant chemotherapy or radiation, or in the choice of postoperative adjuvant therapy. PDAC ranges in appearance from homogeneously isoattenuating masses to heterogeneously hypovascular tumors on CT images; hence, we hypothesize that heterogeneity reflects underlying differences at the histologic or genetic level and will therefore correlate with patient outcome. We quantify heterogeneity of PDAC with texture analysis to predict 2-year survival. Using fuzzy minimum-redundancy maximum-relevance feature selection and a naive Bayes classifier, the proposed features achieve an area under receiver operating characteristic curve (AUC) of 0.90 and accuracy (Ac) of 82.86% with the leave-one-image-out technique and an AUC of 0.80 and Ac of 75.0% with three-fold cross-validation. We conclude that texture analysis can be used to quantify heterogeneity in CT images to accurately predict 2-year survival in patients with pancreatic cancer. From these data, we infer differences in the biological evolution of pancreatic cancer subtypes measurable in imaging and identify opportunities for optimized patient selection for therapy.

  3. Indoor air purificaton using heterogeneous photocatalytic oxidation, Part 2: Kinetic study

    NARCIS (Netherlands)

    Yu, Q.; Ballari, M.; Brouwers, H.J.H.

    2010-01-01

    In part I to this article [1], the application of the heterogeneous photocatalytic oxidation (PCO) theory for the indoor air quality improvement was presented. With a modified TiO2 that can be activated by visible light as the photocatalyst coated on a special wall paper, and one typical indoor air

  4. Identifying functional zones of denitrification in heterogeneous aquifer systems by numerical simulations - a case study

    Science.gov (United States)

    Jang, E.; Kalbacher, T.; He, W.; Shao, H.; Schueth, C.; Kolditz, O.

    2014-12-01

    Nitrate contamination in shallow groundwater is still one of the common problems in many countries. Because of its high solubility and anionic nature, nitrate can easily leach through soil and persist in groundwater for decades. High nitrate concentration has been suggested as a major cause of accelerated eutrophication, methemoglobinemia and gastric cancer. There are several factors influencing the fate of nitrate in groundwater system, which is e.g. distribution of N- sources to soil and groundwater, distribution and amount of reactive substances maintaining denitrification, rate of nitrate degradation and its kinetics, and geological characteristics of the aquifer. Nitrate transport and redox transformation processes are closely linked to complex and spatially distributed physical and chemical interaction, therefore it is difficult to predict and quantify in the field and laboratory experiment. Models can play a key role in elucidation of nitrate reduction pathway in groundwater system and in the design and evaluation of field tests to investigate in situ remediation technologies as well. The goal of the current study is to predict groundwater vulnerability to nitrate, to identify functional zones of denitrification in heterogeneous aquifer systems and to describe the uncertainty of the predictions due to scale effects. For this aim, we developed a kinetic model using multi-component mass transport code OpenGeoSys coupling with IPhreeqc module of the geochemical solver PHREEQC. The developed model included sequential aerobic and nitrate-based respiration, multi-Monod kinetics, multi-species biogeochemical reactions, and geological characteristics of the groundwater aquifer. Moreover water-rock interaction such as secondary mineral precipitation was also included in this model. In this presentation, we focused on the general modelling approach and present the simulation results of nitrate transport simulation in a hypothetical aquifer systems based on data from

  5. Spatial processes decouple management from objectives in a heterogeneous landscape: predator control as a case study.

    Science.gov (United States)

    Mahoney, Peter J; Young, Julie K; Hersey, Kent R; Larsen, Randy T; McMillan, Brock R; Stoner, David C

    2018-04-01

    Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model. With our model, we were able to evaluate spatial congruence between management action (i.e., coyote removal) and objective (i.e., parturient deer site selection) at two distinct scales: the level of the management unit and the individual coyote removal. In the case of the former, our results indicated substantial spatial heterogeneity in expected congruence between removal risk and parturient deer site selection across large areas, and is a reflection of logistical constraints acting on the management strategy and differences in space use between the two species. At the level of the individual removal, we demonstrated that the potential management benefits of a removed coyote were highly variable across all individuals removed and in many cases, spatially distinct from parturient deer resource selection. Our methods and results provide a means of evaluating where we might anticipate an impact of predator control, while emphasizing the need to weight individual removals based on spatial proximity to management objectives in any assessment of large-scale predator control. Although we highlight the importance of spatial context in assessments of predator control strategy, we believe our methods are readily generalizable in any management or large

  6. Simulation Study on the Controllable Dielectrophoresis Parameters of Graphene

    Science.gov (United States)

    Ji, Jian-Long; Liu, Ya-Li; Ge, Yang; Xie, Sheng-Dong; Zhang, Xi; Sang, Sheng-Bo; Jian, Ao-Qun; Duan, Qian-Qian; Zhang, Qiang; Zhang, Wen-Dong

    2017-03-01

    The method of using dielectrophoresis (DEP) to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and discuss the simulation of the graphene assembly process based on the finite element method. The simulated results illustrate that the accelerated motion of graphene is in agreement with the distribution of the electric field squared gradient. We also conduct research on the controllable parameters of the DEP assembly such as the alternating current (AC) frequency, the shape of micro-electrodes, and the ratio of the gap between electrodes to the characteristic/geometric length of graphene (λ). The simulations based on the Clausius-Mossotti factor reveal that both graphene velocity and direction are influenced by the AC frequency. When graphene is close to the electrodes, the shape of micro-electrodes will exert great influence on the velocity of graphene. Also, λ has a great influence on the velocity of graphene. Generally, the velocity of graphene would be greater when λ is in the range of 0.4-0.6. The study is of a theoretical guiding significance in improving the precision and efficiency of the graphene DEP assembly. Supported by the Basic Research Project of Shanxi Province under Grant No 2015021092, the National Natural Science Foundation of China under Grant Nos 61471255, 61474079, 61501316, 51505324 and 51622507, and the National High-Technology Research and Development Program of China under Grant No 2015AA042601.

  7. Future Circular Collider Study FCC-he Baseline Parameters

    CERN Document Server

    Bruning, Oliver; Klein, Max; Pellegrini, Dario; Schulte, Daniel; Zimmermann, Frank

    2017-01-01

    Initial considerations are presented on the FCC-he, the electron-hadron collider con guration within the Future Circular Collider study. This note considers arguments for the choice of the electron beam energy based on physics, ep scattering kinematics and cost. The default con guration for the electron accelerator, as for the LHeC, is chosen to be a multi-turn energy recovery linac external to the proton beam tunnel. The main accelerator parameters of the FCC-he are discussed, assuming the concurrent operation of ep with the 100TeV cms energy pp collider. These are compared with the LHeC design concept, for increased performance as for a Higgs facility using the HL-LHC, and also the high energy HE-LHC ep collider configuration. Initial estimates are also provided for the luminosity performance of electron-ion colliders for the 60 GeV electron ERL when combined with the LHC, the HE-LHC and the FCC ion beams.

  8. Parameter studies of sediments in the Storegga Slide region

    Science.gov (United States)

    Yang, S. L.; Kvalstad, T.; Solheim, A.; Forsberg, C. F.

    2006-09-01

    Based on classification tests, oedometer tests, fall-cone tests and triaxial tests, physical and mechanical properties of sediments in the Storegga Slide region were analysed to assess parameter interrelationships. The data show good relationships between a number of physical and mechanical parameters. Goodness of fit between compression index and various physical parameters can be improved by multiple regression analysis. The interclay void ratio and liquidity index correlate well with the undrained shear strength of clay. Sediments with higher water content, liquid limit, activity, interclay void ratio, plasticity index and liquidity index showed higher compression index and/or lower undrained shear strength. Some relationships between parameters were tested by using data from two other sites south of the Storegga Slide. A better understanding of properties of sediments in regions such as that of the Storegga Slide can be obtained through this approach.

  9. Unobserved heterogeneity in the power law nonhomogeneous Poisson process

    International Nuclear Information System (INIS)

    Asfaw, Zeytu Gashaw; Lindqvist, Bo Henry

    2015-01-01

    A study of possible consequences of heterogeneity in the failure intensity of repairable systems is presented. The basic model studied is the nonhomogeneous Poisson process with power law intensity function. When several similar systems are under observation, the assumption that the corresponding processes are independent and identically distributed is often questionable. In practice there may be an unobserved heterogeneity among the systems. The heterogeneity is modeled by introduction of unobserved gamma distributed frailties. The relevant likelihood function is derived, and maximum likelihood estimation is illustrated. In a simulation study we then compare results when using a power law model without taking into account heterogeneity, with the corresponding results obtained when the heterogeneity is accounted for. A motivating data example is also given. - Highlights: • Consequences of overlooking heterogeneity in similar repairable systems are studied. • Likelihood functions are established for power law NHPP w/ and w/o heterogeneity. • ML estimators for parameters of power law NHPP with heterogeneity are derived. • A simulation study shows the effects of heterogeneity and its ignorance in models

  10. Cost optimization of ADS design: Comparative study of externally driven heterogeneous and homogeneous two-zone subcritical reactor systems

    International Nuclear Information System (INIS)

    Gulik, Volodymyr; Tkaczyk, Alan H.

    2014-01-01

    Highlights: • The optimization of two-zone homogeneous subcritical systems has been performed. • A Serpent model for two-zone heterogeneous subcritical systems has been developed. • The optimization of two-zone heterogeneous subcritical systems has been carried out. • Economically optimal core composition of two-zone subcritical system was found. • The neutron spectra of the heterogeneous subcritical systems have been obtained. - Abstract: Subcritical systems driven by external neutron sources, commonly known as Accelerator-Driven System (ADS), are one type of advanced nuclear reactor exhibiting attractive characteristics, distinguished from the traditional critical systems by their intrinsic safety features. In addition, an ADS can be used for the transmutation of the nuclear waste, accumulated during the operation of existing reactors. The optimization of a subcritical nuclear reactor in terms of materials (fuel content, coolant, etc.), geometrical, and economical parameters is a crucial step in the process of their design and construction. This article describes the optimization modeling performed for homogeneous and heterogeneous two-zone subcritical systems in terms of geometry of the fuel zones. Economical assessment was also carried out for the costs of the fuel in the core of the system. Optimization modeling was performed with the Serpent-1.1.18 Monte Carlo code. The model of a two-zone subcritical system with a fast inner and a thermal gas-cooled graphite-moderated outer zone was developed, simulated, and analyzed. The optimal value for the pitch of fuel elements in the thermal outer zone was investigated from the viewpoint of the cost of subcritical system. As the main goal of ADS development is nuclear waste transmutation, neutron spectra for both fast and thermal zones were obtained for different system configurations. The results of optimization modeling of homogeneous and heterogeneous two-zone subcritical systems show that an optimal

  11. Numerical calculations on heterogeneity of groundwater flow

    International Nuclear Information System (INIS)

    Follin, S.

    1992-01-01

    The upscaling of model parameters is a key issue in many research fields concerned with parameter heterogeneity. The upscaling process allows for fewer model blocks and relaxes the numerical problems caused by high contrasts in the hydraulic conductivity. The trade-offs are dependent on the object but the general drawback is an increasing uncertainty about the representativeness. The present study deals with numerical calculations of heterogeneity of groundwater flow and solute transport in hypothetical blocks of fractured hard rock in a '3m scale' and addresses both conceptual and practical problems in numerical simulation. Evidence that the hydraulic conductivity (K) of the rock mass between major fracture zones is highly heterogeneous in a 3m scale is provided by a large number of field investigations. The present uses the documented heterogeneity and investigates flow and transport in a two-dimensional stochastic continuum characterized by a variance in Y = In(K) of σ y 2 = 16, corresponding to about 12 log 10 cycles in K. The study considers anisotropy, channelling, non-Fickian and Fickian transport, and conditional simulation. The major conclusions are: * heterogeneity gives rise to anisotropy in the upscaling process, * the choice of support scale is crucial for the modelling of solute transport. As a consequence of the obtained results, a two-dimensional stochastic discontinuum model is presented, which provides a tool for linking stochastic continuum models to discrete fracture network models. (au) (14 figs., 136 refs.)

  12. Comparative study of heterogeneous and homogeneous LMFBR cores in some accident conditions

    International Nuclear Information System (INIS)

    Renard, A.; Evrard, G.

    1978-01-01

    An heterogeneous design and a homogeneous one of a LMFBR core with the same power and similar dimensions are compared from the safety point-of-view. The comparison is performed for several accident conditions, such as Loss-of-Flow and Transient Overpower, with the same failure criteria and model assumptions for both cores. Qualitative trends are deduced from the behaviour of the core designs in the investigated transient conditions. (author)

  13. A Preliminary Design Study of Ultra-Long-Life SFR Cores having Heterogeneous Fuel Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Jung, GeonHee; You, WuSeung; Hong, Ser Gi [Kyung Hee University, Yongin (Korea, Republic of)

    2016-10-15

    The PWR and CANDU reactors have provided electricity for several decades in our country but they have produced lots of spent fuels and so the safe and efficient disposal of these spent fuels is one of the main issues in nuclear industry. This type ultra-long-life cores are quite efficient in terms of the amount of spent fuel generation per electricity production and they can be used as an interim storage for PWR or CANDU spent fuel over several tens of years if they use the PWR or CANDU spent fuel as the initial fuel. Typically, the previous works have considered radially homogeneous fuel assemblies in which only blanket or driver fuel rods are employed and they considered axially or radially heterogeneous core configurations with the radially homogeneous fuel assemblies. These core configurations result in the propagation of the power distribution which can lead to the significant temperature changes for each fuel assembly over the time. In this work, the radially heterogeneous fuel assemblies are employed in new ultra-long-life SFR (Sodium-cooled Fast Reactor) cores to minimize the propagation of power distribution by allowing the power propagation in the fuel assemblies. In this work, new small ultra-long life SFR cores were designed with heterogeneous fuel assemblies having both blanket and driver fuel rods to minimize the propagation of power distribution over the core by allowing power propagation from driver rods to blanket rods in fuel assemblies. In particular, high fidelity depletion calculation coupled with heterogeneous Monte Carlo neutron transport calculation was performed to assess the neutronic feasibility of the ultralong life cores. The results of the analysis showed that the candidate core has the cycle length of 77 EFPYs, a small burnup reactivity swing of 1590 pcm and acceptably small SVRs both at BOC and EOC.

  14. Application of personal computers to study the kinetics of heterogeneous isotopic exchange

    International Nuclear Information System (INIS)

    Koernyei, Jozsef; Lakatos, Mihaly

    1985-01-01

    The kinetics of some heterogeneous isotopic exchange reactions of alkaline metal ions between solid (crystalline zirconium phosphate) and liquid phases were investigated. Ion diffusion in solid phase was considered as rate controlling step. The Laplace transformation solution of Fick's II law was used with a Sinclair ZX Spectrum personal computer. In some cases the exchange reaction should be regarded as a superposition of diffusion and a first order process. (author)

  15. Study of the transport parameters of cloud lightning plasmas

    International Nuclear Information System (INIS)

    Chang, Z. S.; Yuan, P.; Zhao, N.

    2010-01-01

    Three spectra of cloud lightning have been acquired in Tibet (China) using a slitless grating spectrograph. The electrical conductivity, the electron thermal conductivity, and the electron thermal diffusivity of the cloud lightning, for the first time, are calculated by applying the transport theory of air plasma. In addition, we investigate the change behaviors of parameters (the temperature, the electron density, the electrical conductivity, the electron thermal conductivity, and the electron thermal diffusivity) in one of the cloud lightning channels. The result shows that these parameters decrease slightly along developing direction of the cloud lightning channel. Moreover, they represent similar sudden change behavior in tortuous positions and the branch of the cloud lightning channel.

  16. Title: Studies on drug switchability showed heterogeneity in methodological approaches: a scoping review.

    Science.gov (United States)

    Belleudi, Valeria; Trotta, Francesco; Vecchi, Simona; Amato, Laura; Addis, Antonio; Davoli, Marina

    2018-05-16

    Several drugs share the same therapeutic indication, including those undergoing patent expiration. Concerns on the interchangeability are frequent in clinical practice, challenging the evaluation of switchability through observational research. To conduct a scoping review of observational studies on drug switchability to identify methodological strategies adopted to deal with bias and confounding. We searched PubMed, EMBASE, and Web of Science (updated 1/31/2017) to identify studies evaluating switchability in terms of effectiveness/safety outcomes or compliance. Three reviewers independently screened studies extracting all characteristics. Strategies to address confounding, particularly, previous drug use and switching reasons were considered. All findings were summarized in descriptive analyses. Thirty-two studies, published in the last 10 years, met the inclusion criteria. Epilepsy, cardiovascular and rheumatology were the most frequently represented clinical areas. 75% of the studies reported data on effectiveness/safety outcomes. The most frequent study design was cohort (65.6%) followed by case-control (21.9%) and self-controlled (12.5%). Case-control and case-crossover studies showed homogeneous methodological strategies to deal with bias and confounding. Among cohort studies, the confounding associated with previous drug use was addressed introducing variables in multivariate model (47.3%) or selecting only adherent patients (14.3%). Around 30% of cohort studies did not report reasons for switching. In the remaining 70%, clinical parameters or previous occurrence of outcomes were measured to identify switching connected with lack of effectiveness or adverse events. This study represents a starting point for researchers and administrators who are approaching the investigation and assessment of issues related to interchangeability of drugs. Copyright © 2018. Published by Elsevier Inc.

  17. Single-cell MALDI-MS as an analytical tool for studying intrapopulation metabolic heterogeneity of unicellular organisms.

    Science.gov (United States)

    Amantonico, Andrea; Urban, Pawel L; Fagerer, Stephan R; Balabin, Roman M; Zenobi, Renato

    2010-09-01

    Heterogeneity is a characteristic feature of all populations of living organisms. Here we make an attempt to validate a single-cell mass spectrometric method for detection of changes in metabolite levels occurring in populations of unicellular organisms. Selected metabolites involved in central metabolism (ADP, ATP, GTP, and UDP-Glucose) could readily be detected in single cells of Closterium acerosum by means of negative-mode matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS). The analytical capabilities of this approach were characterized using standard compounds. The method was then used to study populations of individual cells with different levels of the chosen metabolites. With principal component analysis and support vector machine algorithms, it was possible to achieve a clear separation of individual C. acerosum cells in different metabolic states. This study demonstrates the suitability of mass spectrometric analysis of metabolites in single cells to measure cell-population heterogeneity.

  18. The use of laboratory experiments for the study of conservative solute transport in heterogeneous porous media

    Science.gov (United States)

    Silliman, S. E.; Zheng, L.; Conwell, P.

    Laboratory experiments on heterogeneous porous media (otherwise known as intermediate scale experiments, or ISEs) have been increasingly relied upon by hydrogeologists for the study of saturated and unsaturated groundwater systems. Among the many ongoing applications of ISEs is the study of fluid flow and the transport of conservative solutes in correlated permeability fields. Recent advances in ISE design have provided the capability of creating correlated permeability fields in the laboratory. This capability is important in the application of ISEs for the assessment of recent stochastic theories. In addition, pressure-transducer technology and visualization methods have provided the potential for ISEs to be used in characterizing the spatial distributions of both hydraulic head and local water velocity within correlated permeability fields. Finally, various methods are available for characterizing temporal variations in the spatial distribution (and, thereby, the spatial moments) of solute concentrations within ISEs. It is concluded, therefore, that recent developments in experimental techniques have provided an opportunity to use ISEs as important tools in the continuing study of fluid flow and the transport of conservative solutes in heterogeneous, saturated porous media. Résumé Les hydrogéologues se sont progressivement appuyés sur des expériences de laboratoire sur des milieux poreux hétérogènes (connus aussi par l'expression "Expériences àéchelle intermédiaire", ISE) pour étudier les zones saturées et non saturées des aquifères. Parmi les nombreuses applications en cours des ISE, il faut noter l'étude de l'écoulement de fluide et le transport de solutés conservatifs dans des champs aux perméabilités corrélées. Les récents progrès du protocole des ISE ont donné la possibilité de créer des champs de perméabilités corrélées au laboratoire. Cette possibilité est importante dans l'application des ISE pour l'évaluation des th

  19. The study of biodiesel production using CaO as a heterogeneous catalytic reaction

    Directory of Open Access Journals (Sweden)

    Kamila Colombo

    2017-06-01

    Full Text Available With the aim of developing a process of biodiesel production that is environmentally benign much interest has been focused on the use of solid base catalysts, such as calcium oxide, for the transesterification of vegetable oils with methanol. In the study reported herein a recycling reactor was used in bench scale, with the capacity to produce 3 L of biodiesel. The reactor was designed especially for this research study. A full 23 factorial plan was used to evaluate the process parameters related to this study, in particular, the catalyst concentration, the alcohol to oil molar ratio and the reaction time. Using this equipment for the transesterification reaction resulted in the recovery of the excess alcohol. The reaction products were characterized using gas chromatography and liquid analysis to determine the ester and calcium concentrations, respectively. The main conclusions drawn were that the best conversion percentage (100% of biodiesel was reached when the methanol:oil molar ratio was 6:1, the reaction time was 75 min and the catalyst mass was 3% in relation to the oil mass used in this process. The CaO concentration determined exceeded the limit of concentration defined by legislation and thus a secondary operation was carried out to purify the reaction products obtained. The results of this study showed a high performance, and the proposed experiment could be used as a new and innovative way to produce biodiesel in the future.

  20. Parameter motivated mutual correlation analysis: Application to the study of currency exchange rates based on intermittency parameter and Hurst exponent

    Science.gov (United States)

    Cristescu, Constantin P.; Stan, Cristina; Scarlat, Eugen I.; Minea, Teofil; Cristescu, Cristina M.

    2012-04-01

    We present a novel method for the parameter oriented analysis of mutual correlation between independent time series or between equivalent structures such as ordered data sets. The proposed method is based on the sliding window technique, defines a new type of correlation measure and can be applied to time series from all domains of science and technology, experimental or simulated. A specific parameter that can characterize the time series is computed for each window and a cross correlation analysis is carried out on the set of values obtained for the time series under investigation. We apply this method to the study of some currency daily exchange rates from the point of view of the Hurst exponent and the intermittency parameter. Interesting correlation relationships are revealed and a tentative crisis prediction is presented.

  1. Using PKiKP coda to study heterogeneity in the top layer of the inner core's western hemisphere

    Science.gov (United States)

    Wu, Wenbo; Irving, Jessica C. E.

    2017-05-01

    Significant lateral and depth variations of the inner core's properties, such as the large-scale hemispherical pattern, have been confirmed by a variety of seismological observations. However it is still unclear which dynamic processes in the core are responsible for these variations. Small-scale volumetric heterogeneity has been detected in the top layer of the inner core by PKiKP coda observations. Studies of these small-scale heterogeneities can provide critical information, such as the degree of alignment of iron crystals, the presence of possible partial melt and the grain size of iron crystals, all of which can be used to constrain the dynamic processes of the inner core. However, most previous observations sampled the inner core beneath the Pacific Ocean and Asia, often in the inner core's 'eastern hemisphere'. We use seismic stations in the North America, including the Earthscope Transportable Array, to look at PKiKP and its coda waves. We find 21 events with clear signals. In agreement with previous studies, inner core scattering (ICS), resulting in clear PKiKP coda, is found at epicentral distances of 60°-95°. However, the ICS we observe in these 21 western hemisphere events is weaker than previously reported for the eastern hemisphere. Comparing our observations with numerical simulations, we conclude that this relatively weak ICS indicates small-scale heterogeneity in at least the top layer of the inner core beneath Central America. Combining our clear observations with previous studies suggests either a hemispherical difference, or a regional variation, of small-scale heterogeneity in the inner core.

  2. Composition heterogeneity analysis for DUPIC fuel(I) - Statistical analysis

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hang Bok [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-08-01

    The fuel composition heterogeneity effect on reactor performance parameters was assessed by refueling simulations for three DUPIC fuel options of fuel composition heterogeneity control: the fissile content adjustment, the reactivity control by slightly enriched and depleted uranium, and the reactivity control by natural uranium. For each DUPIC fuel option, the simulations were performed using 30 heterogeneous fuel types which were determined by the agglomerative hierarchical clustering method. The heterogeneity effect was considered during the refueling simulation by randomly selecting fuel types for the refueling operation. The refueling simulations of the heterogeneous core have shown that the key performance parameters such as the maximum channel power (MCP), maximum bundle power (MBP), and channel power peaking factor (CPPF) are close to those of the core that has single fuel type. For the three DUPIC fuel options, the uncertainties of MCP, MBP, and CPPF due to the fuel composition heterogeneity are less than 0.6, 1.5 and 0.8%, respectively, including the uncertainty of the group-average fuel property. This study has shown that the three DUPIC fuel options reduces the composition heterogeneity effectively and the zone power control system has a sufficient margin to adjust the perturbations cased by the fuel composition heterogeneity. 15 refs., 28 figs.,10 tabs. (Author)

  3. Permanently split capacitor motor-study of the design parameters

    Science.gov (United States)

    Sarac, Vasilija; Stefanov, Goce

    2017-09-01

    Paper analyzes the influence of various design parameters on torque of permanently split capacitor motor. Motor analytical model is derived and it is used for calculating the performance characteristics of basic motor model. The acquired analytical model is applied in optimization software that uses genetic algorithms (GA) as an optimization method. Optimized motor model with increased torque is derived by varying three motor parameters in GA program: winding turns ratio, average air gap flux density and motor stack length. Increase of torque has been achieved for nominal operation but also at motor starting. Accuracy of the derived models is verified by Simulink. The acquired values of several motor parameters from transient characteristics of Simulink models are compared with the corresponding values obtained from analytical models of both motors, basic and optimized. Numerical analysis, based on finite element method (FEM), is also performed for both motor models. As a result of the FEM analysis, magnetic flux density in motor cross-section is calculated and adequate conclusions are derived in relation to core saturation and air gap flux density in both motor models.

  4. Study of gas-liquid flow in model porous media for heterogeneous catalysis

    Science.gov (United States)

    Francois, Marie; Bodiguel, Hugues; Guillot, Pierre; Laboratory of the Future Team

    2015-11-01

    Heterogeneous catalysis of chemical reactions involving a gas and a liquid phase is usually achieved in fixed bed reactors. Four hydrodynamic regimes have been observed. They depend on the total flow rate and the ratio between liquid and gas flow rate. Flow properties in these regimes influence transfer rates. Rather few attempts to access local characterization have been proposed yet, though these seem to be necessary to better describe the physical mechanisms involved. In this work, we propose to mimic slices of reactor by using two-dimensional porous media. We have developed a two-dimensional system that is transparent to allow the direct observation of the flow and the phase distribution. While varying the total flow rate and the gas/liquid flow rate ratio, we observe two hydrodynamic regimes: at low flow rate, the gaseous phase is continuous (trickle flow), while it is discontinuous at higher flow rate (pulsed flow). Thanks to some image analysis techniques, we are able to quantify the local apparent liquid saturation in the system. Its fluctuations in time are characteristic of the transition between the two regimes: at low liquid flow rates, they are negligible since the liquid/gas interface is fixed, whereas at higher flow rates we observe an alternation between liquid and gas. This transition between trickle to pulsed flow is in relative good agreement with the existing state of art. However, we report in the pulsed regime important flow heterogeneities at the scale of a few pores. These heterogeneities are likely to have a strong influence on mass transfers. We acknowledge the support of Solvay.

  5. A performance study on the synchronisation of heterogeneous Grid databases using CONStanza

    CERN Document Server

    Pucciani, G; Domenici, Andrea; Stockinger, Heinz

    2010-01-01

    In Grid environments, several heterogeneous database management systems are used in various administrative domains. However, data exchange and synchronisation need to be available across different sites and different database systems. In this article we present our data consistency service CONStanza and give details on how we achieve relaxed update synchronisation between different database implementations. The integration in existing Grid environments is one of the major goals of the system. Performance tests have been executed following a factorial approach. Detailed experimental results and a statistical analysis are presented to evaluate the system components and drive future developments. (C) 2010 Elsevier B.V. All rights reserved.

  6. Numerical study for melting heat transfer and homogeneous-heterogeneous reactions in flow involving carbon nanotubes

    Science.gov (United States)

    Hayat, Tasawar; Muhammad, Khursheed; Alsaedi, Ahmed; Asghar, Saleem

    2018-03-01

    Present work concentrates on melting heat transfer in three-dimensional flow of nanofluid over an impermeable stretchable surface. Analysis is made in presence of porous medium and homogeneous-heterogeneous reactions. Single and multi-wall CNTs (carbon nanotubes) are considered. Water is chosen as basefluid. Adequate transformations yield the non-linear ordinary differential systems. Solution of emerging problems is obtained using shooting method. Impacts of influential variables on velocity and temperature are discussed graphically. Skin friction coefficient and Nusselt number are numerically discussed. The results for MWCNTs and SWCNTs are compared and examined.

  7. Impacts of Bus-stops on the Speed of Motorized Vehicles under Heterogeneous Traffic Conditions: A Case-Study of Delhi, India

    Directory of Open Access Journals (Sweden)

    Prateek Bansal

    2014-06-01

    Full Text Available The presence of friction generators1 such as bus-stops, intersections, petrol pumps and pedestrian crossings, etc. significantly influences the speed of traffic stream. Among all the friction generators, understanding the impact of bus-stops is particularly important from planning and modeling perspective in the Indian context. Therefore, this study presents a methodology to quantify the impact of bus-stops on the speed of other motorized vehicles (the total motorized vehicle fleet minus the buses under heterogeneous traffic conditions. The methodology was validated on the typical urban arterials in Delhi, India. Two types of data, location of bus-stops and speed profiles of motorized vehicles, were collected by GPS and V-box respectively. These two data sets were mapped and merged using ArcGIS. To understand the nature of traffic stream near bus-stops, ‘influence regions’ of bus-stops were extracted. Later, characteristic parameters such as lengths of the influence regions and average speeds in the influence regions were computed. Finally, 95% confidence intervals of these characteristic parameters were obtained and regression analysis was performed to quantify the impact of bus-stops on the speed of motorized vehicles. The results of study suggest that the influence region of bus-stops on the corridors investigated varies from 140–170 meters and average speed of motorized vehicles in the influence region is reduced by 26–38% of the free flow speed. These findings can better inform planners about the speeds used in traffic flow and travel demand modeling under heterogeneous conditions by helping them in accounting for the speed-reducing impacts of bus-stops. Moreover, transit planners may also consider the magnitudes and characteristics of the influence regions of bus-stops while determining their locations along the corridor to minimize their adverse impacts on the speed of other motorized vehicles.

  8. The Effect of Wettability Heterogeneity on Relative Permeability of Two-Phase Flow in Porous Media: A Lattice Boltzmann Study

    Science.gov (United States)

    Zhao, Jianlin; Kang, Qinjun; Yao, Jun; Viswanathan, Hari; Pawar, Rajesh; Zhang, Lei; Sun, Hai

    2018-02-01

    Relative permeability is a critical parameter characterizing multiphase flow in porous media and it is strongly dependent on the wettability. In many situations, the porous media are nonuniformly wet. To investigate the effect of wettability heterogeneity on relative permeability of two-phase flow in porous media, a multi-relaxation-time color-gradient lattice Boltzmann model is adopted to simulate oil/water two-phase flow in porous media with different oil-wet solid fractions. For the water phase, when the water saturation is high, the relative permeability of water increases with the increase of oil-wet solid fraction under a constant water saturation. However, as the water saturation decreases to an intermediate value (about 0.4-0.7), the relative permeability of water in fractionally wet porous media could be lower than that in purely water-wet porous media, meaning additional flow resistance exists in the fractionally wet porous media. For the oil phase, similar phenomenon is observed. This phenomenon is mainly caused by the wettability-related microscale fluid distribution. According to both our simulation results and theoretical analysis, it is found that the relative permeability of two-phase flow in porous media is strongly related to three parameters: the fluid saturation, the specific interfacial length of fluid, and the fluid tortuosity in the flow direction. The relationship between the relative permeability and these parameters under different capillary numbers is explored in this paper.

  9. Study on the formation of heterogeneous structures in leached layers during the corrosion process of glass

    Directory of Open Access Journals (Sweden)

    Willemien Anaf

    2010-11-01

    Full Text Available Le verre, corrodé dans des conditions naturelles, montre souvent des hétérogénéités dans la couche lixiviée, comme une structure lamellaire ou des inclusions de MnO2 ou Ca3(PO42. La formation de ces hétérogénéités n’est pas encore bien comprise. Des structures de ce type ont été produites artificiellement en laboratoire en immergeant des échantillons de verre dans des solutions riches en métaux. Les résultats expérimentaux ont été comparés avec des théories décrivant la corrosion du verre.Glass that corrodes under natural conditions often shows heterogeneities in the leached layer, such as a lamellar structure or inclusions of MnO2 or Ca3(PO42. The formation of these heterogeneities is still not well understood. By means of experiments under laboratory conditions, our aim was to artificially generate specific structures. Therefore, glass samples were immersed in metal-rich solutions. The experimental results were compared with theories describing glass corrosion from a molecular point of view.

  10. Study Heterogeneity and Estimation of Prevalence of Primary Aldosteronism: A Systematic Review and Meta-Regression Analysis.

    Science.gov (United States)

    Käyser, Sabine C; Dekkers, Tanja; Groenewoud, Hans J; van der Wilt, Gert Jan; Carel Bakx, J; van der Wel, Mark C; Hermus, Ad R; Lenders, Jacques W; Deinum, Jaap

    2016-07-01

    For health care planning and allocation of resources, realistic estimation of the prevalence of primary aldosteronism is necessary. Reported prevalences of primary aldosteronism are highly variable, possibly due to study heterogeneity. Our objective was to identify and explain heterogeneity in studies that aimed to establish the prevalence of primary aldosteronism in hypertensive patients. PubMed, EMBASE, Web of Science, Cochrane Library, and reference lists from January 1, 1990, to January 31, 2015, were used as data sources. Description of an adult hypertensive patient population with confirmed diagnosis of primary aldosteronism was included in this study. Dual extraction and quality assessment were the forms of data extraction. Thirty-nine studies provided data on 42 510 patients (nine studies, 5896 patients from primary care). Prevalence estimates varied from 3.2% to 12.7% in primary care and from 1% to 29.8% in referral centers. Heterogeneity was too high to establish point estimates (I(2) = 57.6% in primary care; 97.1% in referral centers). Meta-regression analysis showed higher prevalences in studies 1) published after 2000, 2) from Australia, 3) aimed at assessing prevalence of secondary hypertension, 4) that were retrospective, 5) that selected consecutive patients, and 6) not using a screening test. All studies had minor or major flaws. This study demonstrates that it is pointless to claim low or high prevalence of primary aldosteronism based on published reports. Because of the significant impact of a diagnosis of primary aldosteronism on health care resources and the necessary facilities, our findings urge for a prevalence study whose design takes into account the factors identified in the meta-regression analysis.

  11. Correction factors for photon spectrometry in nuclear parameters study

    International Nuclear Information System (INIS)

    Patrao, Karla Cristina de Souza

    2004-10-01

    The goal of this work was the determination, using metrologic severity, the factors of correction for coincidences XX, Xγ and γγ and the factors of transference of efficiency for use in gamma spectrometry. On this way, it was carried through by determination of nuclear parameters of a nuclide used in medicine diagnostic ( 201 Tl) and the standardization of two environmental samples, of regular and irregular geometry, proceeding from the residual (ashes and slag) from the nuclear industry. The results shows that this adopted methodology is valid, and it allows its application for many different nuclides, including complex decay schema nuclides, using only photons spectrometry techniques on semiconductor detectors. (author)

  12. Comparative study of radiation shielding parameters for bismuth borate glasses

    International Nuclear Information System (INIS)

    Kaundal, Rajinder Singh

    2016-01-01

    Melt and quench technique was used for the preparation of glassy samples of the composition x Bi 2 O 3- (1-x) B 2 O 3 where x= .05 to .040. XCOM computer program is used for the evaluation of gamma-ray shielding parameters of the prepared glass samples. Further the values of mass attenuation coefficients, effective atomic number and half value layer for the glassy samples have been calculated in the energy range from 1KeV to 100GeV. Rigidity of the glass samples have been analyzed by molar volume of the prepared glass samples. (author)

  13. Comparative study of radiation shielding parameters for bismuth borate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Kaundal, Rajinder Singh, E-mail: rajinder_apd@yahoo.com [Department of Physics, School of Physical Sciences, Lovely Professional University, Phagwara, Punjab (India)

    2016-07-15

    Melt and quench technique was used for the preparation of glassy samples of the composition x Bi{sub 2}O{sub 3-}(1-x) B{sub 2}O{sub 3} where x= .05 to .040. XCOM computer program is used for the evaluation of gamma-ray shielding parameters of the prepared glass samples. Further the values of mass attenuation coefficients, effective atomic number and half value layer for the glassy samples have been calculated in the energy range from 1KeV to 100GeV. Rigidity of the glass samples have been analyzed by molar volume of the prepared glass samples. (author)

  14. Comparative Study of Radiation Shielding Parameters for Bismuth Borate Glasses

    OpenAIRE

    Kaundal, Rajinder Singh

    2016-01-01

    Melt and quench technique was used for the preparation of glassy samples of the composition x Bi2O3-(1-x) B2O3 where x= .05 to .040. XCOM computer program is used for the evaluation of gamma-ray shielding parameters of the prepared glass samples. Further the values of mass attenuation coefficients, effective atomic number and half value layer for the glassy samples have been calculated in the energy range from 1KeV to 100GeV. Rigidity of the glass samples have been analyzed by molar volume of...

  15. Micromechanical modelling of heterogeneous materials in transient conditions: contributions for the study of the ageing of structural components under service

    International Nuclear Information System (INIS)

    Masson, R.

    2010-01-01

    The modelling of the mechanical behaviour of structural materials is increasingly based on microstructural parameters. Within this framework, homogenisation methods have the advantage of providing deductive methods which, starting from the properties and space distribution of each constituent, deduce the effective properties of the heterogeneous material. Nevertheless, many applications make still difficult the use of homogenisation methods. It is in particular the case of structural materials presenting elastic-viscoplastic behaviours and subjected to both non-monotone and ageing loadings. To progress on the treatment by homogenisation of these useful situations constitutes precisely the main idea of the various contributions presented in this work.For linear elasticity, new expressions for the computation of the Eshelby tensor are first of all established in order to improve the efficiency of homogenisation methods usually used. Always for linear behaviours but now viscoelastic, various approximations associated with the use of the theorem of correspondence are studied and compared. The equivalence of one of these approximations (the so-called 'collocation method') with an internal variables formulation of the effective behaviour is shown. This internal variables formulation leads to exact results in some situations and strongly simplifies the treatment of ageing linear viscoelastic behaviours. In the case of elastic-viscoplastic behaviours, is added to the previous difficulty (viscoelastic coupling) that of the treatment of nonlinear behaviour. Comparisons made between various families of estimates make it possible to determine the effects of the various approximations needed to deal with these nonlinearities. An improvement is also proposed and implemented in a particular case while the extension of this internal variable formulation to nonlinear behaviours is discussed. Finally, full-field computations of microstructures are also tackled by considering the

  16. Heterogeneous Gossip

    Science.gov (United States)

    Frey, Davide; Guerraoui, Rachid; Kermarrec, Anne-Marie; Koldehofe, Boris; Mogensen, Martin; Monod, Maxime; Quéma, Vivien

    Gossip-based information dissemination protocols are considered easy to deploy, scalable and resilient to network dynamics. Load-balancing is inherent in these protocols as the dissemination work is evenly spread among all nodes. Yet, large-scale distributed systems are usually heterogeneous with respect to network capabilities such as bandwidth. In practice, a blind load-balancing strategy might significantly hamper the performance of the gossip dissemination.

  17. THE EVOLUTION OF HETERGENEOUS 'CLUMPY JETS': A PARAMETER STUDY

    International Nuclear Information System (INIS)

    Yirak, Kristopher; Schroeder, Ed; Frank, Adam; Cunningham, Andrew J.

    2012-01-01

    We investigate the role discrete clumps embedded in an astrophysical jet play on the jet's morphology and line emission characteristics. By varying clumps' size, density, position, and velocity, we cover a range of parameter space motivated by observations of objects such as the Herbig-Haro object HH 34. We here extend the results presented in Yirak et al., including how analysis of individual observations may lead to spurious sinusoidal variation whose parameters vary widely over time, owing chiefly to interactions between clumps. The goodness of fits, while poor in all simulations, are best when clump-clump collisions are minimal. Our results indicate that a large velocity dispersion leads to a clump-clump collision-dominated flow which disrupts the jet beam. Finally, we present synthetic emission images of Hα and [S II] and note an excess of [S II] emission along the jet length as compared to observations. This suggests that observed beams undergo earlier processing, if they are present at all.

  18. SU-E-J-263: Repeatability of SUV and Texture Parameters in Serial PET Studies

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; Humm, J; Nehmeh, S; Schoder, H [Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

    2015-06-15

    Purpose: Standardized uptake values (SUV) are standard quantitative PET measures of FDG tumor uptake used,and are used as a tool to monitor response to therapy. Textural analysis is emerging as a new tool for assessing intratumoral heterogeneity which may allow better tissue characterization and improved prediction of response and survival rate.Understanding what variations may be expected in these parameters is key in order to make decisions based on how the change throughout the course of treatment. The aim of this study was to assess repeatability in SUV measures and texture parameters,and establish criteria that differentiate changes associated with treatment rather than statistical variability. Methods: Eighty patients,167 random lesions total,were scanned in a GE Discovery STE PET/CT Scanner. One field-of-view was chosen centered on the largest lesion observed in a clinical whole-body FDG PET.Immediately following,a gated 9 min scan was acquired in list mode,without changing the patient’s position between any scans. Data was replayed into 3 time bins,3 min each,in order to insure equivalent noise characteristics in each replicate.Data was reconstructed into 128×128×47 square matrices.One VOI was drawn over each lesion for each patient and used to segment all 3 replicates. The mean.max and peak SUV were calculated for each VOI and replicate. First-order textural features were also calculated (skewness and kurtosis). Repeatability was calculated as the average standard deviation over the mean for the 3 repeated measurements for each lesion. Results: The average percent error in the SUV max,peak and mean were 3.4%(0– 12.9%),1.9% (0–7.5%),2.8% (0–12.2%),respectively.For skewness and kurtosis they were 10.9% and 17.8%. Conclusion: We have shown that there is a large variation in %error in SUV measures across patients. SUVpeak is the least variable and kurtosis and skewness parameters are less reliable thatn SUVs.Higher order textures are be.

  19. SU-E-J-263: Repeatability of SUV and Texture Parameters in Serial PET Studies

    International Nuclear Information System (INIS)

    Schwartz, J; Humm, J; Nehmeh, S; Schoder, H

    2015-01-01

    Purpose: Standardized uptake values (SUV) are standard quantitative PET measures of FDG tumor uptake used,and are used as a tool to monitor response to therapy. Textural analysis is emerging as a new tool for assessing intratumoral heterogeneity which may allow better tissue characterization and improved prediction of response and survival rate.Understanding what variations may be expected in these parameters is key in order to make decisions based on how the change throughout the course of treatment. The aim of this study was to assess repeatability in SUV measures and texture parameters,and establish criteria that differentiate changes associated with treatment rather than statistical variability. Methods: Eighty patients,167 random lesions total,were scanned in a GE Discovery STE PET/CT Scanner. One field-of-view was chosen centered on the largest lesion observed in a clinical whole-body FDG PET.Immediately following,a gated 9 min scan was acquired in list mode,without changing the patient’s position between any scans. Data was replayed into 3 time bins,3 min each,in order to insure equivalent noise characteristics in each replicate.Data was reconstructed into 128×128×47 square matrices.One VOI was drawn over each lesion for each patient and used to segment all 3 replicates. The mean.max and peak SUV were calculated for each VOI and replicate. First-order textural features were also calculated (skewness and kurtosis). Repeatability was calculated as the average standard deviation over the mean for the 3 repeated measurements for each lesion. Results: The average percent error in the SUV max,peak and mean were 3.4%(0– 12.9%),1.9% (0–7.5%),2.8% (0–12.2%),respectively.For skewness and kurtosis they were 10.9% and 17.8%. Conclusion: We have shown that there is a large variation in %error in SUV measures across patients. SUVpeak is the least variable and kurtosis and skewness parameters are less reliable thatn SUVs.Higher order textures are be

  20. Study of the correlation of IVIM parameter maps with FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Delso, Gaspar, E-mail: gaspar.delso@usz.ch [GE Healthcare, Waukesha, WI (United States); Lee, Sangwoo [GE Healthcare, Waukesha, WI (United States); Porto, Miguel; Hüllner, Martin; Veit-Haibach, Patrick [Department of Medical Imaging, University Hospital, Zurich (Switzerland)

    2014-01-11

    Intravoxel incoherent motion (IVIM) is a magnetic resonance technique to quantify the influence of microscopic perfusion-related motion and differentiate it from pure molecular diffusion. IVIM has the potential to provide valuable clinical information about microcirculation in the capillary network of healthy tissues as well as malignant tumors. Our goal was to study the correlation of IVIM parameter maps with concurrent FDG-PET data, in view of their potential use in clinical PET/MR protocols. Methods: Data were acquired from ten oncology patients using a tri-modality setup and fitted with a bi-exponential model. The fitting was first solved in the least squares sense and then again using iteratively reweighted least squares. The resulting parameter maps were compared with PET FDG data by an experienced radiologist. Results: Among the pathologies encountered in our patient population were lesions of the liver, spleen, kidney, abdominal wall, prostate and cervix. The qualitative comparison with PET confirmed that IVIM maps provide complementary information about functional inhomogeneity within the tumor. Visual inspection by experienced radiologists showed improved reading of tumor heterogeneity in six of our ten patients when considering FDG uptake together with perfusion fraction maps. The use of a large set of b values was instrumental for data validation and outlier rejection. Robust fitting was shown to increase the accuracy of the fit in 70% of the voxels, leading to average changes of IVIM parametric maps: perfusion fraction f∈[3.9×10{sup –3}, 4.7×10{sup −2}], diffusion coefficient D ∈[−1.2×10{sup −4}, −3.0×10{sup −6}] and pseudo-diffusion coefficient D{sup *}∈[−1.6×10{sup −1}, −9.2×10{sup −3}]. Conclusions: The results suggest that IVIM imaging could be successfully integrated in clinical PET/MR protocols. Clinical validation shows the complementarity of obtained parameter maps with concurrent FDG PET data. Ongoing work is

  1. Importance of scatter compensation algorithm in heterogeneous tissue for the radiation dose calculation of small lung nodules. A clinical study

    International Nuclear Information System (INIS)

    Baba, Yuji; Murakami, Ryuji; Mizukami, Naohisa; Morishita, Shoji; Yamashita, Yasuyuki; Araki, Fujio; Moribe, Nobuyuki; Hirata, Yukinori

    2004-01-01

    The purpose of this study was to compare radiation doses of small lung nodules calculated with beam scattering compensation and those without compensation in heterogeneous tissues. Computed tomography (CT) data of 34 small (1-2 cm: 12 nodules, 2-3 cm 11 nodules, 3-4 cm 11 nodules) lung nodules were used in the radiation dose measurements. Radiation planning for lung nodule was performed with a commercially available unit using two different radiation dose calculation methods: the superposition method (with scatter compensation in heterogeneous tissues), and the Clarkson method (without scatter compensation in heterogeneous tissues). The energy of the linac photon used in this study was 10 MV and 4 MV. Monitor unit (MU) to deliver 10 Gy at the center of the radiation field (center of the nodule) calculated with the two methods were compared. In 1-2 cm nodules, MU calculated by Clarkson method (MUc) was 90.0±1.1% (4 MV photon) and 80.5±2.7% (10 MV photon) compared to MU calculated by superposion method (MUs), in 2-3 cm nodules, MUc was 92.9±1.1% (4 MV photon) and 86.6±2.8% (10 MV photon) compared to MUs, and in 3-4 cm nodules, MUc was 90.5±2.0% (4 MV photon) and 90.1±1.7% (10 MV photon) compared to MUs. In 1-2 cm nodules, MU calculated without lung compensation (MUn) was 120.6±8.3% (4 MV photon) and 95.1±4.1% (10 MV photon) compared to MU calculated by superposion method (MUs), in 2-3 cm nodules, MUc was 120.3±11.5% (4 MV photon) and 100.5±4.6% (10 MV photon) compared to MUs, and in 3-4 cm nodules, MUc was 105.3±9.0% (4 MV photon) and 103.4±4.9% (10 MV photon) compared to MUs. The MU calculated without lung compensation was not significantly different from the MU calculated by superposition method in 2-3 cm nodules. We found that the conventional dose calculation algorithm without scatter compensation in heterogeneous tissues substantially overestimated the radiation dose of small nodules in the lung field. In the calculation of dose distribution of small

  2. Epidemic Spreading with Heterogeneous Awareness on Human Networks

    Directory of Open Access Journals (Sweden)

    Yanling Lu

    2017-01-01

    Full Text Available The spontaneous awareness behavioral responses of individuals have a significant impact on epidemic spreading. In this paper, a modified Susceptible-Alert-Infected-Susceptible (SAIS epidemic model with heterogeneous awareness is presented to study epidemic spreading in human networks and the impact of heterogeneous awareness on epidemic dynamics. In this model, when susceptible individuals receive awareness information about the presence of epidemic from their infected neighbor nodes, they will become alert individuals with heterogeneous awareness rate. Theoretical analysis and numerical simulations show that heterogeneous awareness can enhance the epidemic threshold with certain conditions and reduce the scale of virus outbreaks compared with no awareness. What is more, for the same awareness parameter, it also shows that heterogeneous awareness can slow effectively the spreading size and does not delay the arrival time of epidemic spreading peak compared with homogeneous awareness.

  3. (58 Indices, Metaphors and Montages. The Heterogeneous Work in Current Latin American Literary Studies

    Directory of Open Access Journals (Sweden)

    Francisco Gelman Constantin

    2017-09-01

    Full Text Available As contemporary literary scholars challenge the ruling exclusionary criteria for the homogenization of their objects, while at the same time the biopolitical turn on literary theory criticizes representational understandings of the bond between language and the body, this paper suggests to address said relationship with recourse to the Lacanian notion of the ‘montage of heterogeneous’, which was brought forth toward a redefinition of the psychoanalytical concept of drive. Drawing from the notion of ‘heterogeneous literatures’, I advocate a theoretical genealogy from Bataille to Lacan (while Nancy, Foucault and Butler are also summoned to the discussion in order to come to terms with the rethinking of the objects for literary scholarship demanded by works such as Emilio García Wehbi’s performance piece 58 indicios sobre el cuerpo, along with his and Nora Lezano’s poetical- photographical essay Communitas.

  4. Macroscopic heterogeneity of liver fat: an MR-based study in type-2 diabetic patients

    International Nuclear Information System (INIS)

    Capitan, Violaine; Lefevre, Pierre-Henri; Favelier, Sylvain; Loffroy, Romaric; Krause, Denis; Petit, Jean-Michel; Aho, Serge; Hillon, Patrick; Cercueil, Jean-Pierre; Guiu, Boris

    2012-01-01

    To assess the heterogeneity of liver fat deposition with MR of the liver in type-2 diabetic (T2D) patients. We enrolled 121 consecutive T2D patients. The reference standard was 3.0-T 1 H-MR spectroscopy. Hepatic steatosis was defined as liver fat content (LFC) ≥5.56 %. A triple-echo gradient-echo sequence corrected for T1 recovery and T2* decay was used to calculate LFC in left and right livers and hepatic segments. Analyses were performed using a linear mixed model. Fifty-nine (48.8 %) patients had liver steatosis, whereas 62 (51.2 %) did not. Steatosis was greater in the right than in the left liver (P < 0.0001) [mean difference: 1.32 % (range: 0.01-8.75 %)]. In seven patients (5.8 %), LFC was <5.56 % in one side of the liver, whereas it was ≥5.56 % in the other. Steatosis of the left and right liver was heterogeneous at the segmental level in both non-steatotic (P < 0.001 and P < 0.0001 respectively) and steatotic (P < 0.0001 and P = 0.0002 respectively) patients [mean maximum difference: 3.98 % (range: 0.74-19.32 %)]. In 23 patients (19 %), LFC was <5.56 % in one segment, whereas it was ≥5.56 % in at least one other. Overall, the mean segmental/lobar variability of steatosis is low. However, segmental variability can sometimes lead to a misdiagnosis. (orig.)

  5. Heterogeneous reactions of carbonyl sulfide on mineral oxides: mechanism and kinetics study

    Directory of Open Access Journals (Sweden)

    Y. Liu

    2010-11-01

    Full Text Available The heterogeneous reactions of carbonyl sulfide (OCS on the typical mineral oxides in the mineral dust particles were investigated using a Knudsen cell flow reactor and a diffuse reflectance UV-vis spectroscopy. The reaction pathway for OCS on mineral dust was identified based on the gaseous products and surface species. The hydrolysis of OCS and succeeding oxidation of intermediate products readily took place on α-Al2O3, MgO, and CaO. Reversible and irreversible adsorption of OCS were observed on α-Fe2O3 and ZnO, respectively, whereas no apparent uptake of OCS by SiO2 and TiO2 was observed. The reactivity of OCS on these oxides depends on both the basicity of oxides and the decomposition reactivity of oxides for H2S. Based on the individual uptake coefficients and chemical composition of authentic mineral dust, the uptake coefficient (γBET of mineral dust was estimated to be in the range of 3.84×10−7–2.86×10−8. The global flux of OCS due to heterogeneous reactions and adsorption on mineral dust was estimated at 0.13–0.29 Tg yr−1, which is comparable to the annual flux of OCS for its reaction with ·OH.

  6. Macroscopic heterogeneity of liver fat: an MR-based study in type-2 diabetic patients

    Energy Technology Data Exchange (ETDEWEB)

    Capitan, Violaine; Lefevre, Pierre-Henri; Favelier, Sylvain; Loffroy, Romaric; Krause, Denis [CHU (University Hospital), Department of Radiology, 14 rue Paul Gaffarel, BP 77908, Dijon (France); CHU (University Hospital), BP 77908, Dijon (France); Petit, Jean-Michel [CHU (University Hospital), Department of Endocrinology, Diabetology, and Metabolic Diseases, BP 77908, Dijon (France); CHU (University Hospital), BP 77908, Dijon (France); Aho, Serge [CHU (University Hospital), Department of Biostatistics and Medical Informatics, Dijon (France); CHU (University Hospital), BP 77908, Dijon (France); Hillon, Patrick [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Hepatology, BP 77908, Dijon (France); CHU (University Hospital), BP 77908, Dijon (France); Cercueil, Jean-Pierre; Guiu, Boris [CHU (University Hospital), Department of Radiology, 14 rue Paul Gaffarel, BP 77908, Dijon (France); University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), BP 77908, Dijon (France)

    2012-10-15

    To assess the heterogeneity of liver fat deposition with MR of the liver in type-2 diabetic (T2D) patients. We enrolled 121 consecutive T2D patients. The reference standard was 3.0-T {sup 1}H-MR spectroscopy. Hepatic steatosis was defined as liver fat content (LFC) {>=}5.56 %. A triple-echo gradient-echo sequence corrected for T1 recovery and T2* decay was used to calculate LFC in left and right livers and hepatic segments. Analyses were performed using a linear mixed model. Fifty-nine (48.8 %) patients had liver steatosis, whereas 62 (51.2 %) did not. Steatosis was greater in the right than in the left liver (P < 0.0001) [mean difference: 1.32 % (range: 0.01-8.75 %)]. In seven patients (5.8 %), LFC was <5.56 % in one side of the liver, whereas it was {>=}5.56 % in the other. Steatosis of the left and right liver was heterogeneous at the segmental level in both non-steatotic (P < 0.001 and P < 0.0001 respectively) and steatotic (P < 0.0001 and P = 0.0002 respectively) patients [mean maximum difference: 3.98 % (range: 0.74-19.32 %)]. In 23 patients (19 %), LFC was <5.56 % in one segment, whereas it was {>=}5.56 % in at least one other. Overall, the mean segmental/lobar variability of steatosis is low. However, segmental variability can sometimes lead to a misdiagnosis. (orig.)

  7. Waves spontaneously generated by heterogeneity in oscillatory media

    Science.gov (United States)

    Cui, Xiaohua; Huang, Xiaodong; Hu, Gang

    2016-05-01

    Wave propagation is an important characteristic for pattern formation and pattern dynamics. To date, various waves in homogeneous media have been investigated extensively and have been understood to a great extent. However, the wave behaviors in heterogeneous media have been studied and understood much less. In this work, we investigate waves that are spontaneously generated in one-dimensional heterogeneous oscillatory media governed by complex Ginzburg-Landau equations; the heterogeneity is modeled by multiple interacting homogeneous media with different system control parameters. Rich behaviors can be observed by varying the control parameters of the systems, whereas the behavior is incomparably simple in the homogeneous cases. These diverse behaviors can be fully understood and physically explained well based on three aspects: dispersion relation curves, driving-response relations, and wave competition rules in homogeneous systems. Possible applications of heterogeneity-generated waves are anticipated.

  8. A study on cell heterogeneity effects in the Monju core. Evaluation using the continuous energy Monte Carlo code MVP

    International Nuclear Information System (INIS)

    Morohashi, Yuko; Ishibashi, Junichi; Nishi, Hiroshi

    2002-03-01

    The criticality analysis of the MONJU initial critical core was conducted based on conventional methods developed by the JUPITER program. Effective cross sections were created, considering self-shielding effects, from the JAERI Fast Set (JFS-3-J3.2); group constants in 70 energy groups, which were processed from the Japanese Evaluated Nuclear Data Library (JENDL-3.2). These were used in the standard calculation method: a 3-Dimensional Hexagonal-Z whole core calculation by diffusion theory. This standard calculation, however, involves several approximations. The continuous neutron energy spectrum is divided into 70 discrete energy groups and continuous spatial coordinates are represented by assembly-wise spatial meshes. Original transport equations are solved by diffusion theory (isotropic scattering) approximation and fine structures in fuel assemblies, such as fuel pins or wrapper tubes, are processed into cell-wise homogeneous mixture. To improve the accuracy of the results, these approximations are compensated for by applying corresponding correction factors. Cell heterogeneity effects, among them, were evaluated to be 0.3-0.4% Δk/kk' by diffusion calculations based on the group constants, obtained by heterogeneous cell model calculations. This method, however, has the drawback that it assumes that there is no interdependency of the related approximations; energy grouping, diffusion approximation, etc. A study on cell heterogeneity effects has been conducted using the continuous energy Monte Carlo method to validate the adequacy of this non-interdependency assumption. As a result, cell heterogeneity effects slightly larger than those from conventional methods have been obtained: 0.54% Δk/kk' for the initial critical core, and 0.50% Δk/kk' for the initial full power core. Dependency on plutonium enrichment and fuel temperature has also been identified, which implies the dependency of the cell heterogeneity effects on the specific core conditions. Grouping

  9. Dynamic Parameter Identification of Subject-Specific Body Segment Parameters Using Robotics Formalism: Case Study Head Complex.

    Science.gov (United States)

    Díaz-Rodríguez, Miguel; Valera, Angel; Page, Alvaro; Besa, Antonio; Mata, Vicente

    2016-05-01

    Accurate knowledge of body segment inertia parameters (BSIP) improves the assessment of dynamic analysis based on biomechanical models, which is of paramount importance in fields such as sport activities or impact crash test. Early approaches for BSIP identification rely on the experiments conducted on cadavers or through imaging techniques conducted on living subjects. Recent approaches for BSIP identification rely on inverse dynamic modeling. However, most of the approaches are focused on the entire body, and verification of BSIP for dynamic analysis for distal segment or chain of segments, which has proven to be of significant importance in impact test studies, is rarely established. Previous studies have suggested that BSIP should be obtained by using subject-specific identification techniques. To this end, our paper develops a novel approach for estimating subject-specific BSIP based on static and dynamics identification models (SIM, DIM). We test the validity of SIM and DIM by comparing the results using parameters obtained from a regression model proposed by De Leva (1996, "Adjustments to Zatsiorsky-Seluyanov's Segment Inertia Parameters," J. Biomech., 29(9), pp. 1223-1230). Both SIM and DIM are developed considering robotics formalism. First, the static model allows the mass and center of gravity (COG) to be estimated. Second, the results from the static model are included in the dynamics equation allowing us to estimate the moment of inertia (MOI). As a case study, we applied the approach to evaluate the dynamics modeling of the head complex. Findings provide some insight into the validity not only of the proposed method but also of the application proposed by De Leva (1996, "Adjustments to Zatsiorsky-Seluyanov's Segment Inertia Parameters," J. Biomech., 29(9), pp. 1223-1230) for dynamic modeling of body segments.

  10. Study of heterogeneous nuclear reactor lattice properties in multizone systems; Ispitivanje karakteristika resetke heterogenih nuklearnih reaktora u visezonim sistemima

    Energy Technology Data Exchange (ETDEWEB)

    Raisic, N M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Yugoslavia)

    1964-07-01

    Described analysis of substitution experiments and its comparison with the classic procedures showed that it could be successfully applied for processing the experimental results. This method shows some advantages and some deficiencies compared to classic methods. Precision of the method is considered sufficient for design of nuclear facilities. Routine standards used in design of nuclear facilities demand following precision of nuclear parameters: about 5% during feasibility study and design of heavy water facility with natural uranium; 2 - 3% in the phase of parameters optimisation and preparing the main project; 1% during optimization of operation. Accuracy of core parameters obtained by analysis of substitution experiments show that they could be successfully used in the phase of reactor parameters optimisation. It is possible to increase the precision of critical parameters and thus apply the proposed method for analysis of reactor parameters needed in the phase of operation optimization.

  11. Experimental constraints on transport from dimensionless parameter scaling studies

    International Nuclear Information System (INIS)

    Petty, C.C.; Luce, T.C.; Baker, D.R.

    1998-02-01

    The scalings of heat transport with safety factor (q), normalized collisionality (v), plasma beta (β), and relative gyroradius (ρ*) have been measured on the DIII-D tokamak. The measured ρ* β and v scalings of heat transport indicate that E x B transport from drive wave turbulence is a plausible basis for anomalous transport. For high confinement (H) mode plasmas where the safety factor was varied at fixed magnetic shear, the effective (or one-fluid) thermal diffusivity was found to scale like χ eff ∝ q 2.3±0.64 , with the ion and electron fluids having the same q scaling to within the experimental errors except near the plasma edge. The scaling of the thermal confinement time with safety factor was in good agreement with this local transport dependence, τ th ∝ q -2.42±0.31 ; however, when the magnetic shear was allowed to vary to keep q 0 fixed during the (edge) safety factor scan, a weaker global dependence was observed, τ th ∝ q 95 -1.43±0.23 . This weaker dependence was mainly due to the change in the local value of q between the two types of scans. The combined ρ*, β, v and q scalings of heat transport for H-mode plasmas on DIII-D reproduce the empirical confinement scaling using physical (dimensionless) parameters with the exception of weaker power degradation

  12. Experimental constraints on transport from dimensionless parameter scaling studies

    International Nuclear Information System (INIS)

    Petty, C.C.; Luce, T.C.; Baker, D.R.; Ballet, B.; Carlstrom, T.N.; Cordey, J.G.; DeBoo, J.C.; Gohil, P.; Groebner, R.J.; Rice, B.W.; Thomas, D.M.; Wade, M.R.; Waltz, R.E.

    1998-01-01

    The scalings of heat transport with safety factor (q), normalized collisionality (ν), plasma beta (β), and relative gyroradius (ρ * ) have been measured on the DIII-D tokamak [Fusion Technol. 8, 441 (1985)]. The measured ρ * , β and ν scalings of heat transport indicate that ExB transport from drift wave turbulence is a plausible basis for anomalous transport. For high confinement (H) mode plasmas where the safety factor was varied at fixed magnetic shear, the effective (or one-fluid) thermal diffusivity was found to scale like χ eff ∝q 2.3±0.64 , with the ion and electron fluids having the same q scaling to within the experimental errors except near the plasma edge. The scaling of the thermal confinement time with safety factor was in good agreement with this local transport dependence, τ th ∝q -2.42±0.31 ; however, when the magnetic shear was allowed to vary to keep q 0 fixed during the (edge) safety factor scan, a weaker global dependence was observed, τ th ∝q 95 -1.43±0.23 . This weaker dependence was mainly due to the change in the local value of q between the two types of scans. The combined ρ * , β , ν and q scalings of heat transport for H-mode plasmas on DIII-D reproduce the empirical confinement scaling using physical (dimensional) parameters with the exception of weaker power degradation. copyright 1998 American Institute of Physics

  13. Support vector regression for porosity prediction in a heterogeneous reservoir: A comparative study

    Science.gov (United States)

    Al-Anazi, A. F.; Gates, I. D.

    2010-12-01

    In wells with limited log and core data, porosity, a fundamental and essential property to characterize reservoirs, is challenging to estimate by conventional statistical methods from offset well log and core data in heterogeneous formations. Beyond simple regression, neural networks have been used to develop more accurate porosity correlations. Unfortunately, neural network-based correlations have limited generalization ability and global correlations for a field are usually less accurate compared to local correlations for a sub-region of the reservoir. In this paper, support vector machines are explored as an intelligent technique to correlate porosity to well log data. Recently, support vector regression (SVR), based on the statistical learning theory, have been proposed as a new intelligence technique for both prediction and classification tasks. The underlying formulation of support vector machines embodies the structural risk minimization (SRM) principle which has been shown to be superior to the traditional empirical risk minimization (ERM) principle employed by conventional neural networks and classical statistical methods. This new formulation uses margin-based loss functions to control model complexity independently of the dimensionality of the input space, and kernel functions to project the estimation problem to a higher dimensional space, which enables the solution of more complex nonlinear problem optimization methods to exist for a globally optimal solution. SRM minimizes an upper bound on the expected risk using a margin-based loss function ( ɛ-insensitivity loss function for regression) in contrast to ERM which minimizes the error on the training data. Unlike classical learning methods, SRM, indexed by margin-based loss function, can also control model complexity independent of dimensionality. The SRM inductive principle is designed for statistical estimation with finite data where the ERM inductive principle provides the optimal solution (the

  14. Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case-control study.

    Science.gov (United States)

    Sawabe, Michi; Ito, Hidemi; Takahara, Taishi; Oze, Isao; Kawakita, Daisuke; Yatabe, Yasushi; Hasegawa, Yasuhisa; Murakami, Shingo; Matsuo, Keitaro

    2018-01-01

    Major salivary gland cancers (M-SGCs) are rare, and have distinct heterogeneous histopathological subtypes. To the authors' knowledge, no consistent evidence of an association between cigarette smoking and the risk of M-SGCs has appeared to date. Furthermore, evidence of potential heterogeneity in the impact of smoking on histopathological subtypes is scarce, despite the fact that the histopathological subtypes of M-SGC exhibit different genetic features. The authors conducted a case-control study to investigate the association between smoking and M-SGC by histopathological subtype. Cases were 81 patients with M-SGCs and the controls were 810 age-matched and sex-matched first-visit outpatients without cancer treated at Aichi Cancer Center Hospital from 1988 to 2005. Odds ratios (OR) and 95% confidence intervals (95% CI) were assessed by conditional logistic regression analysis with adjustment for potential confounders. Smoking was found to be associated with a significantly increased risk of M-SGC overall, with an OR of 3.45 (95% CI, 1.58-7.51; P =.001) for heavy smokers compared with never-smokers. A significant dose-response relationship was observed (P for trend, .001). When stratified by histological subtype, no obvious impact of smoking was observed among patients with mucoepidermoid carcinoma (MEC). In contrast, smoking demonstrated a significantly increased risk of M-SGCs other than MEC, with an OR of 5.15 (95% CI, 2.06-12.87; Psmoking on risk between MEC and M-SGCs other than MEC (P for heterogeneity, .052). The results of the current study demonstrate a significant positive association between cigarette smoking and the risk of M-SGC overall. However, the impact of smoking appeared to be limited to M-SGCs other than MEC. Cancer 2018;124:118-24. © 2017 American Cancer Society. © 2017 American Cancer Society.

  15. Strategies to reduce mass and photons transfer limitations in heterogeneous photocatalytic processes: Hexavalent chromium reduction studies.

    Science.gov (United States)

    Marinho, Belisa A; Cristóvão, Raquel O; Djellabi, Ridha; Caseiro, Ana; Miranda, Sandra M; Loureiro, José M; Boaventura, Rui A R; Dias, Madalena M; Lopes, José Carlos B; Vilar, Vítor J P

    2018-07-01

    The current work presents different approaches to overcome mass and photon transfer limitations in heterogeneous photocatalytic processes applied to the reduction of hexavalent chromium to its trivalent form in the presence of a sacrificial agent. Two reactor designs were tested, a monolithic tubular photoreactor (MTP) and a micro-meso-structured photoreactor (NETmix), both presenting a high catalyst surface area per reaction liquid volume. In order to reduce photon transfer limitations, the tubular photoreactor was packed with transparent cellulose acetate monolithic structures (CAM) coated with the catalyst by a dip-coating method. For the NETmix reactor, a thin film of photocatalyst was uniformly deposited on the front glass slab (GS) or on the network of channels and chambers imprinted in the back stainless steel slab (SSS) using a spray system. The reaction rate for the NETmix photoreactor was evaluated for two illumination sources, solar light or UVA-LEDs, using the NETmix with the front glass slab or/and back stainless steel slab coated with TiO 2 -P25. The reusability of the photocatalytic films on the NETmix walls was also evaluated for three consecutive cycles using fresh Cr(VI) solutions. The catalyst reactivity in combination with the NETmix-SSS photoreactor is almost 70 times superior to one obtained with the MTP. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Studies of axial-leakage simulations for homogeneous and heterogeneous EBR-II core configurations

    International Nuclear Information System (INIS)

    Grimm, K.N.; Meneghetti, D.

    1985-08-01

    When calculations of flux are done in less than three dimensions, leakage-absorption cross sections are normally used to model leakages (flows) in the dimensions for which the flux is not calculated. Since the neutron flux is axially dependent, the leakages, and hence the leakage-absorption cross sections, are also axially dependent. Therefore, to obtain axial flux profiles (or reaction rates) for individual subassemblies, an XY-geometry calculation delineating each subassembly has to be done at several axial heights with space- and energy-dependent leakage-absorption cross sections that are appropriate for each height. This report discusses homogeneous and heterogeneous XY-geometry calculations at various axial locations and using several differing assumptions for the calculation of the leakage-absorption cross section. The positive (outward) leakage-absorption cross sections are modeled as actual leakage absorptions, but the negative (inward) leakage-absorption cross sections are modeled as either negative leakage absorptions (+-B 2 method) or positive downscatter cross sections [the Σ/sub s/(1 → g) method]. 3 refs., 52 figs., 10 tabs

  17. Applying the reciprocal dose principle to heterogeneous phantoms: practical experience from Monte Carlo studies

    International Nuclear Information System (INIS)

    Cristy, M.; Williams, L.R.

    1983-01-01

    The reciprocity theorem states that for any pair of regions in a uniform isotropic or uniform scatterless model, the specific fraction (PHI) is independent of which region is designated source and which is designated target. Although the conditions of these models are not met by phantoms heterogeneous in tissue composition and density, calculations with a Monte Carlo radiation transport code show that in many cases the reciprocal PHIs from photon radiation are approximately equal. This 'reciprocity principle' is valid within a factor of 2(Snyder) or about 20% (Mayneord and Clarke), except when one of the organs in the pair considered is the skeleton, where the reciprocal PHIs may differ by as much as a factor of 4. The principle holds within at least 10% when both organs are of near-unit-density. When one of the organs is near the tissue-vacuum boundary (skin, breasts, or testes), reciprocal PHIs may differ by as much as 10% or so at energies where scattering is marked. When one of the organs is the lungs or the whole body, a comparable error may occur at some energies. (author)

  18. Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies

    Energy Technology Data Exchange (ETDEWEB)

    Velden, Floris H.P. van; Cheebsumon, Patsuree; Yaqub, Maqsood; Hoekstra, Otto S.; Lammertsma, Adriaan A.; Boellaard, Ronald [VU University Medical Center, Department of Nuclear Medicine and PET Research, PO Box 7057, Amsterdam (Netherlands); Smit, Egbert F. [VU University Medical Center, Department of Pulmonary Diseases, Amsterdam (Netherlands)

    2011-09-15

    Standardized uptake values (SUV) are commonly used for quantification of whole-body [{sup 18}F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies. Changes in SUV following therapy, however, only provide a proper measure of response in case of homogeneous FDG uptake in the tumour. The purpose of this study was therefore to implement and characterize a method that enables quantification of heterogeneity in tumour FDG uptake. Cumulative SUV-volume histograms (CSH), describing % of total tumour volume above % threshold of maximum SUV (SUV{sub max}), were calculated. The area under a CSH curve (AUC) is a quantitative index of tumour uptake heterogeneity, with lower AUC corresponding to higher degrees of heterogeneity. Simulations of homogeneous and heterogeneous responses were performed to assess the value of AUC-CSH for measuring uptake and/or response heterogeneity. In addition, partial volume correction and image denoising was applied prior to calculating AUC-CSH. Finally, the method was applied to a number of human FDG scans. Partial volume correction and noise reduction improved CSH curves. Both simulations and clinical examples showed that AUC-CSH values corresponded with level of tumour heterogeneity and/or heterogeneity in response. In contrast, this correspondence was not seen with SUV{sub max} alone. The results indicate that the main advantage of AUC-CSH above other measures, such as 1/COV (coefficient of variation), is the possibility to measure or normalize AUC-CSH in different ways. AUC-CSH might be used as a quantitative index of heterogeneity in tracer uptake. In response monitoring studies it can be used to address heterogeneity in response. (orig.)

  19. Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies

    International Nuclear Information System (INIS)

    Velden, Floris H.P. van; Cheebsumon, Patsuree; Yaqub, Maqsood; Hoekstra, Otto S.; Lammertsma, Adriaan A.; Boellaard, Ronald; Smit, Egbert F.

    2011-01-01

    Standardized uptake values (SUV) are commonly used for quantification of whole-body [ 18 F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies. Changes in SUV following therapy, however, only provide a proper measure of response in case of homogeneous FDG uptake in the tumour. The purpose of this study was therefore to implement and characterize a method that enables quantification of heterogeneity in tumour FDG uptake. Cumulative SUV-volume histograms (CSH), describing % of total tumour volume above % threshold of maximum SUV (SUV max ), were calculated. The area under a CSH curve (AUC) is a quantitative index of tumour uptake heterogeneity, with lower AUC corresponding to higher degrees of heterogeneity. Simulations of homogeneous and heterogeneous responses were performed to assess the value of AUC-CSH for measuring uptake and/or response heterogeneity. In addition, partial volume correction and image denoising was applied prior to calculating AUC-CSH. Finally, the method was applied to a number of human FDG scans. Partial volume correction and noise reduction improved CSH curves. Both simulations and clinical examples showed that AUC-CSH values corresponded with level of tumour heterogeneity and/or heterogeneity in response. In contrast, this correspondence was not seen with SUV max alone. The results indicate that the main advantage of AUC-CSH above other measures, such as 1/COV (coefficient of variation), is the possibility to measure or normalize AUC-CSH in different ways. AUC-CSH might be used as a quantitative index of heterogeneity in tracer uptake. In response monitoring studies it can be used to address heterogeneity in response. (orig.)

  20. Parameters for determining inoculated pack/challenge study protocols.

    Science.gov (United States)

    2010-01-01

    The National Advisory Committee on Microbiological Criteria for Foods developed guidelines for conducting challenge studies on pathogen inhibition and inactivation studies in a variety of foods. The document is intended for use by the food industry, including food processors, food service operators, and food retailers; federal, state, and local food safety regulators; public health officials; food testing laboratories; and process authorities. The document is focused on and limited to bacterial inactivation and growth inhibition and does not make specific recommendations with respect to public health. The Committee concluded that challenge studies should be designed considering the most current advances in methodologies, current thinking on pathogens of concern, and an understanding of the product preparation, variability, and storage conditions. Studies should be completed and evaluated under the guidance of an expert microbiologist in a qualified laboratory and should include appropriate statistical design and data analyses. This document provides guidelines for choice of microorganisms for studies, inoculum preparation, inoculum level, methods of inoculation, incubation temperatures and times, sampling considerations, and interpreting test results. Examples of appropriately designed growth inhibition and inactivation studies are provided.

  1. A Comparative Study of the Effect of Homogeneous and Heterogeneous Collaborative Interaction on the Development of EFL Learners’ Writing Skill

    Directory of Open Access Journals (Sweden)

    Parviz Maftoon

    2009-05-01

    Full Text Available This study investigates the effect of homogeneous and heterogeneous peer interaction on the development of Iranian EFL learners’ writing skill. Sixty female students of TEFL participated in the study. The participants were divided into two groups based on their English proficiency test scores. The homogeneous group consisted of 14 participants paired with partners with similar English proficiency test scores, while the heterogeneous group consisted of 16 participants who were paired with partners who had higher test scores. The pairs had interaction and peer collaboration before carrying out three types of writing tasks. The Repeated Measures ANOVA was used to compare the student writers’ pretest writing scores with their three post-test scores. The results showed that both groups, very similarly, had significantly higher post-test scores in all three writing tasks. The findings are explained based on the sociocultural theory and Vygotsky’s notion of the zone of proximal development (ZPD. The study offers several important pedagogical implications and suggestions for further research.

  2. Implications of Heterogeneity in Multiple Myeloma

    Directory of Open Access Journals (Sweden)

    Sanjay de Mel

    2014-01-01

    Full Text Available Multiple myeloma is the second most common hematologic malignancy in the world. Despite improvement in outcome, the disease is still incurable for most patients. However, not all myeloma are the same. With the same treatment, some patients can have very long survival whereas others can have very short survival. This suggests that there is underlying heterogeneity in myeloma. Studies over the years have revealed multiple layers of heterogeneity. First, clinical parameters such as age and tumor burden could significantly affect outcome. At the genetic level, there are also significant heterogeneity ranging for chromosome numbers, genetic translocations, and genetic mutations. At the clonal level, there appears to be significant clonal heterogeneity with multiple clones coexisting in the same patient. At the cell differentiation level, there appears to be a hierarchy of clonally related cells that have different clonogenic potential and sensitivity to therapies. These levels of complexities present challenges in terms of treatment and prognostication as well as monitoring of treatment. However, if we can clearly delineate and dissect this heterogeneity, we may also be presented with unique opportunities for precision and personalized treatment of myeloma. Some proof of concepts of such approaches has been demonstrated.

  3. Overview of medium heterogeneity and transport processes

    International Nuclear Information System (INIS)

    Tsang, Y.; Tsang, C.F.

    1993-11-01

    Medium heterogeneity can have significant impact on the behavior of solute transport. Tracer breakthrough curves from transport in a heterogeneous medium are distinctly different from that in a homogeneous porous medium. Usually the shape of the breakthrough curves are highly non-symmetrical with a fast rise at early times and very long tail at late times, and often, they consist of multiple peaks. Moreover, unlike transport in a homogeneous medium where the same transport parameters describe the entire medium, transport through heterogeneous media gives rise to breakthrough curves which have strong spatial dependence. These inherent characteristics of transport in heterogeneous medium present special challenge to the performance assessment of a potential high level nuclear waste repository with respect to the possible release of radio nuclides to the accessible environment. Since an inherently desirable site characteristic for a waste repository is that flow and transport should be slow, then transport measurements in site characterization efforts will necessarily be spatially small and temporally short compare to the scales which are of relevance to performance assessment predictions. In this paper we discuss the role of medium heterogeneity in site characterization and performance assessment. Our discussion will be based on a specific example of a 3D heterogeneous stochastic model of a site generally similar to, the Aespoe Island, the site of the Hard Rock Laboratory in Southern Sweden. For our study, alternative 3D stochastic fields of hydraulic conductivities conditioned on ''point'' measurements shall be generated. Results of stochastic flow and transport simulations would be used to address the issues of (1) the relationship of tracer breakthrough with the structure of heterogeneity, and (2) the inference from small scale testing results to large scale and long term predictions

  4. Kinetics study of heterogeneous reactions of ozone with erucic acid using an ATR-IR flow reactor.

    Science.gov (United States)

    Leng, Chunbo; Hiltner, Joseph; Pham, Hai; Kelley, Judas; Mach, Mindy; Zhang, Yunhong; Liu, Yong

    2014-03-07

    The ozone initiated heterogeneous oxidation of erucic acid (EA) thin film was investigated using a flow system combined with attenuated total reflection infrared spectroscopy (ATR-IR) over wide ranges of ozone concentrations (0.25-60 ppm), thin film thickness (0.1-1.0 μm), temperatures (263-298 K), and relative humidities (0-80% RH) for the first time. Pseudo-first-order rate constants, kapp, and overall reactive uptake coefficients, γ, were obtained through changes in the absorbance of C[double bond, length as m-dash]O stretching bands at 1695 cm(-1), which is assigned to the carbonyl group in carboxylic acid. Results showed that the reaction followed the Langmuir-Hinshelwood mechanism and kapp was largely dominated by surface reaction over bulk phase reaction. In addition, both the kapp and the γ values showed very strong temperature dependences (∼two orders of magnitude) over the temperature range; in contrast, they only slightly increased with increasing RH values from 0-80%. According to the kapp values as a function of temperature, the activation energy for the heterogeneous reaction was estimated to be 80.6 kJ mol(-1). Our results have suggested that heterogeneous reactions between ozone and unsaturated solid surfaces likely have a substantially greater temperature dependence than liquid ones. Moreover, the hygroscopic properties of EA thin films before and after exposure to ozone were also studied by measurement of water uptake. Based on the hygroscopicity data, the insignificant RH effect on reaction kinetics was probably due to the relatively weak water uptake by the unreacted and reacted EA thin films.

  5. Pinning of the Contact Line during Evaporation on Heterogeneous Surfaces: Slowdown or Temporary Immobilization? Insights from a Nanoscale Study.

    Science.gov (United States)

    Zhang, Jianguo; Müller-Plathe, Florian; Leroy, Frédéric

    2015-07-14

    The question of the effect of surface heterogeneities on the evaporation of liquid droplets from solid surfaces is addressed through nonequilibrium molecular dynamics simulations. The mechanism behind contact line pinning which is still unclear is discussed in detail on the nanoscale. Model systems with the Lennard-Jones interaction potential were employed to study the evaporation of nanometer-sized cylindrical droplets from a flat surface. The heterogeneity of the surface was modeled through alternating stripes of equal width but two chemical types. The first type leads to a contact angle of 67°, and the other leads to a contact angle of 115°. The stripe width was varied between 2 and 20 liquid-particle diameters. On the surface with the narrowest stripes, evaporation occurred at constant contact angle as if the surface was homogeneous, with a value of the contact angle as predicted by the regular Cassie-Baxter equation. When the width was increased, the contact angle oscillated during evaporation between two boundaries whose values depend on the stripe width. The evaporation behavior was thus found to be a direct signature of the typical size of the surface heterogeneity domains. The contact angle both at equilibrium and during evaporation could be predicted from a local Cassie-Baxter equation in which the surface composition within a distance of seven fluid-particle diameters around the contact line was considered, confirming the local nature of the interactions that drive the wetting behavior of droplets. More importantly, we propose a nanoscale explanation of pinning during evaporation. Pinning should be interpreted as a drastic slowdown of the contact line dynamics rather than a complete immobilization of it during a transition between two contact angle boundaries.

  6. Kinetic Study of Application of ZnO as a Photocatalyst in Heterogeneous Medium

    Directory of Open Access Journals (Sweden)

    J. J. Vora

    2009-01-01

    Full Text Available The photocatalytic degradation of 2,4-dinitrophenol over ZnO was carried out in the presence of light. Control experiments were carried out. The photocatalytic degradation of 2,4-dinitrophenol was observed spectro-photmerically. The various parameters like concentrations of substrate, pH, amounts and band gaps of semiconductor, impact of light intensity, sensitizers and radical quenchers affected the kinetics of the degradation process. A probable mechanism for this process has been proposed.

  7. Application of Voxel Phantoms to Study the Influence of Heterogeneous Distribution of Actinides in Lungs on In Vivo Counting Calibration Factors Using Animal Experimentations

    Energy Technology Data Exchange (ETDEWEB)

    Lamart, S.; Pierrat, N.; De Carlan, L.; Franck, D. [IRSN/DRPH/SDI/LEDI, BP 17, F-92 262 Fontenay-aux-Roses (France); Dudoignon, N. [IRSN/DRPH/SRBE/LRPAT, BP 17, F-92 262 Fontenay-aux-Roses (France); Rateau, S.; Van der Meeren, A.; Rouit, E. [CEA/DSV/DRR/SRCA/LRT BP no 12, F-91680 Bruyeres-le-Chatel (France); Bottlaender, M. [CEA/SHFJ, 4, place du General Leclerc F-91400 Orsay (France)

    2006-07-01

    Calibration of lung counting system dedicated to retention assessment of actinides in the lungs remains critical due to large uncertainties in calibration factors. Among them, the detector positioning, the chest wall thickness and composition (muscle/fat) assessment, and the distribution of the contamination are the main parameters influencing the detector response. In order to reduce these uncertainties, a numerical approach based on the application of voxel phantoms (numerical phantoms based on tomographic images, CT or MRI) associated to a Monte-Carlo code (namely M.C.N.P.) was developed. It led to the development of a dedicated tool, called O.E.D.I.P.E., that allows to easily handle realistic voxel phantoms for the simulation of in vivo measurement (or dose calculation, application that will not be presented in this paper). The goal of this paper is to present our study of the influence of the lung distribution on calibration factors using both animal experimentations and our numerical method. Indeed, physical anthropomorphic phantoms used for calibration always consider a uniform distribution of the source in the lungs, which is not true in many contamination conditions. The purpose of the study is to compare the response of the measurement detectors using a real distribution of actinide particles in the lungs, obtained from animal experimentations, with the homogeneous one considered as the reference. This comparison was performed using O.E.D.I.P.E. that can almost simulate any source distribution. A non human primate was contaminated heterogeneously by intra-tracheal administration of actinide oxide. After euthanasia, gamma spectrometry measurements were performed on the pulmonary lobes to obtain the distribution of the contamination in the lungs. This realistic distribution was used to simulate an heterogeneous contamination in the numerical phantom of the non human primate, which was compared with a simulation of an homogeneous contamination presenting the

  8. Application of Voxel Phantoms to Study the Influence of Heterogeneous Distribution of Actinides in Lungs on In Vivo Counting Calibration Factors Using Animal Experimentations

    International Nuclear Information System (INIS)

    Lamart, S.; Pierrat, N.; De Carlan, L.; Franck, D.; Dudoignon, N.; Rateau, S.; Van der Meeren, A.; Rouit, E.; Bottlaender, M.

    2006-01-01

    Calibration of lung counting system dedicated to retention assessment of actinides in the lungs remains critical due to large uncertainties in calibration factors. Among them, the detector positioning, the chest wall thickness and composition (muscle/fat) assessment, and the distribution of the contamination are the main parameters influencing the detector response. In order to reduce these uncertainties, a numerical approach based on the application of voxel phantoms (numerical phantoms based on tomographic images, CT or MRI) associated to a Monte-Carlo code (namely M.C.N.P.) was developed. It led to the development of a dedicated tool, called O.E.D.I.P.E., that allows to easily handle realistic voxel phantoms for the simulation of in vivo measurement (or dose calculation, application that will not be presented in this paper). The goal of this paper is to present our study of the influence of the lung distribution on calibration factors using both animal experimentations and our numerical method. Indeed, physical anthropomorphic phantoms used for calibration always consider a uniform distribution of the source in the lungs, which is not true in many contamination conditions. The purpose of the study is to compare the response of the measurement detectors using a real distribution of actinide particles in the lungs, obtained from animal experimentations, with the homogeneous one considered as the reference. This comparison was performed using O.E.D.I.P.E. that can almost simulate any source distribution. A non human primate was contaminated heterogeneously by intra-tracheal administration of actinide oxide. After euthanasia, gamma spectrometry measurements were performed on the pulmonary lobes to obtain the distribution of the contamination in the lungs. This realistic distribution was used to simulate an heterogeneous contamination in the numerical phantom of the non human primate, which was compared with a simulation of an homogeneous contamination presenting the

  9. studies on growth, organs weight and haematological parameters of ...

    African Journals Online (AJOL)

    user

    2012-06-01

    Jun 1, 2012 ... Maize which is the most available basal energy feedstuff is in constant demand for human and animal nutrition and for industrial processing (Esonu, 2000). The study was conducted to evaluate the effect of feeding graded level of cassava root meal flour on haematological and growth performance of broiler.

  10. Soil water balance scenario studies using predicted soil hydraulic parameters

    NARCIS (Netherlands)

    Nemes, A.; Wösten, J.H.M.; Bouma, J.; Várallyay, G.

    2006-01-01

    Pedotransfer functions (PTFs) have become a topic drawing increasing interest within the field of soil and environmental research because they can provide important soil physical data at relatively low cost. Few studies, however, explore which contributions PTFs can make to land-use planning, in

  11. Comparison study of selected geophysical and geotechnical parameters

    DEFF Research Database (Denmark)

    Nissen, Randi Warncke; Poulsen, Søren Erbs

    Successful foundation of constructions relies on accurate characterization of the geotechnical properties of the subsurface. By implementing data from geophysical surveys, the placement of geotechnical drillings can be significantly improved, potentially reducing the number of required drillings....... This case study is mainly to compare geophysical investigations (MEP/IP) with existing PACES data and information from geotechnical drillings....

  12. Vesicle Encapsulation Studies Reveal that Single Molecule Ribozyme Heterogeneities Are Intrinsic

    Science.gov (United States)

    Okumus, Burak; Wilson, Timothy J.; Lilley, David M. J.; Ha, Taekjip

    2004-01-01

    Single-molecule measurements have revealed that what were assumed to be identical molecules can differ significantly in their static and dynamic properties. One of the most striking examples is the hairpin ribozyme, which was shown to exhibit two to three orders of magnitude variation in folding kinetics between molecules. Although averaged behavior of single molecules matched the bulk solution data, it was not possible to exclude rigorously the possibility that the variations around the mean values arose from different ways of interacting with the surface environment. To test this, we minimized the molecules' interaction with the surface by encapsulating DNA or RNA molecules inside 100- to 200-nm diameter unilamellar vesicles, following the procedures described by Haran and coworkers. Vesicles were immobilized on a supported lipid bilayer via biotin-streptavidin linkages. We observed no direct binding of DNA or RNA on the supported bilayer even at concentrations exceeding 100 nM, indicating that these molecules do not bind stably on the membrane. Since the vesicle diameter is smaller than the resolution of optical microscopy, the lateral mobility of the molecules is severely constrained, allowing long observation periods. We used fluorescence correlation spectroscopy, nuclease digestion, and external buffer exchange to show that the molecules were indeed encapsulated within the vesicles. When contained within vesicles, the natural form of the hairpin ribozyme exhibited 50-fold variation in both folding and unfolding rates in 0.5 mM Mg2+, which is identical to what was observed from the molecules tethered directly on the surface. This strongly indicates that the observed heterogeneity in dynamic properties does not arise as an artifact of surface attachment, but is intrinsic to the nature of the molecules. PMID:15454471

  13. IDENTIFIABILITY VERSUS HETEROGENEITY IN GROUNDWATER MODELING SYSTEMS

    Directory of Open Access Journals (Sweden)

    A M BENALI

    2003-06-01

    Full Text Available Review of history matching of reservoirs parameters in groundwater flow raises the problem of identifiability of aquifer systems. Lack of identifiability means that there exists parameters to which the heads are insensitive. From the guidelines of the study of the homogeneous case, we inspect the identifiability of the distributed transmissivity field of heterogeneous groundwater aquifers. These are derived from multiple realizations of a random function Y = log T  whose probability distribution function is normal. We follow the identifiability of the autocorrelated block transmissivities through the measure of the sensitivity of the local derivatives DTh = (∂hi  ∕ ∂Tj computed for each sample of a population N (0; σY, αY. Results obtained from an analysis of Monte Carlo type suggest that the more a system is heterogeneous, the less it is identifiable.

  14. Parameter study on dynamic behavior of ITER tokamak scaled model

    International Nuclear Information System (INIS)

    Nakahira, Masataka; Takeda, Nobukazu

    2004-12-01

    This report summarizes that the study on dynamic behavior of ITER tokamak scaled model according to the parametric analysis of base plate thickness, in order to find a reasonable solution to give the sufficient rigidity without affecting the dynamic behavior. For this purpose, modal analyses were performed changing the base plate thickness from the present design of 55 mm to 100 mm, 150 mm and 190 mm. Using these results, the modification plan of the plate thickness was studied. It was found that the thickness of 150 mm gives well fitting of 1st natural frequency about 90% of ideal rigid case. Thus, the modification study was performed to find out the adequate plate thickness. Considering the material availability, transportation and weldability, it was found that the 300mm thickness would be a limitation. The analysis result of 300mm thickness case showed 97% fitting of 1st natural frequency to the ideal rigid case. It was however found that the bolt length was too long and it gave additional twisting mode. As a result, it was concluded that the base plate thickness of 150mm or 190mm gives sufficient rigidity for the dynamic behavior of the scaled model. (author)

  15. Ambient pressure sensitivity of microbubbles investigated through a parameter study

    DEFF Research Database (Denmark)

    Andersen, Klaus Scheldrup; Jensen, Jørgen Arendt

    2009-01-01

    Measurements on microbubbles clearly indicate a relation between the ambient pressure and the acoustic behavior of the bubble. The purpose of this study was to optimize the sensitivity of ambient pressure measurements, using the subharmonic component, through microbubble response simulations....... The behavior of two microbubbles corresponding to two different contrast agents was investigated as a function of driving pulse and ambient overpressure, pov. Simulations of Levovist using a rectangular driving pulse show an almost linear reduction in the subharmonic component as pov is increased. For a 20...... found, although the reduction is not completely linear as a function of the ambient pressure....

  16. Identification of material parameters for plasticity models: A comparative study on the finite element model updating and the virtual fields method

    Science.gov (United States)

    Martins, J. M. P.; Thuillier, S.; Andrade-Campos, A.

    2018-05-01

    The identification of material parameters, for a given constitutive model, can be seen as the first step before any practical application. In the last years, the field of material parameters identification received an important boost with the development of full-field measurement techniques, such as Digital Image Correlation. These techniques enable the use of heterogeneous displacement/strain fields, which contain more information than the classical homogeneous tests. Consequently, different techniques have been developed to extract material parameters from full-field measurements. In this study, two of these techniques are addressed, the Finite Element Model Updating (FEMU) and the Virtual Fields Method (VFM). The main idea behind FEMU is to update the parameters of a constitutive model implemented in a finite element model until both numerical and experimental results match, whereas VFM makes use of the Principle of Virtual Work and does not require any finite element simulation. Though both techniques proved their feasibility in linear and non-linear constitutive models, it is rather difficult to rank their robustness in plasticity. The purpose of this work is to perform a comparative study in the case of elasto-plastic models. Details concerning the implementation of each strategy are presented. Moreover, a dedicated code for VFM within a large strain framework is developed. The reconstruction of the stress field is performed through a user subroutine. A heterogeneous tensile test is considered to compare FEMU and VFM strategies.

  17. Heterogeneous gas core reactor

    International Nuclear Information System (INIS)

    Han, K.I.

    1977-01-01

    Preliminary investigations of a heterogeneous gas core reactor (HGCR) concept suggest that this potential power reactor offers distinct advantages over other existing or conceptual reactor power plants. One of the most favorable features of the HGCR is the flexibility of the power producing system which allows it to be efficiently designed to conform to a desired optimum condition without major conceptual changes. The arrangement of bundles of moderator/coolant channels in a fissionable gas or mixture of gases makes a truly heterogeneous nuclear reactor core. It is this full heterogeneity for a gas-fueled reactor core which accounts for the novelty of the heterogeneous gas core reactor concept and leads to noted significant advantages over previous gas core systems with respect to neutron and fuel economy, power density, and heat transfer characteristics. The purpose of this work is to provide an insight into the design, operating characteristics, and safety of a heterogeneous gas core reactor system. The studies consist mainly of neutronic, energetic and kinetic analyses of the power producing and conversion systems as a preliminary assessment of the heterogeneous gas core reactor concept and basic design. The results of the conducted research indicate a high potential for the heterogeneous gas core reactor system as an electrical power generating unit (either large or small), with an overall efficiency as high as 40 to 45%. The HGCR system is found to be stable and safe, under the conditions imposed upon the analyses conducted in this work, due to the inherent safety of ann expanding gaseous fuel and the intrinsic feedback effects of the gas and water coolant

  18. Experimental Studies of the Transport Parameters of Warm Dense Matter

    Energy Technology Data Exchange (ETDEWEB)

    Chouffani, Khalid [Idaho State Univ., Pocatello, ID (United States)

    2014-12-01

    There is a need to establish fundamental properties of matter and energy under extreme physical conditions. Although high energy density physics (HEDP) research spans a wide range of plasma conditions, there is one unifying regime that is of particular importance and complexity: that of warm dense matter, the transitional state between solid state condensed matter and energetic plasmas. Most laboratory experimental conditions, including inertial confinement implosion, fall into this regime. Because all aspects of laboratory-created high-energy-density plasmas transition through the warm dense matter regime, understanding the fundamental properties to determine how matter and energy interact in this regime is an important aspect of major research efforts in HEDP. Improved understanding of warm dense matter would have significant and wide-ranging impact on HEDP science, from helping to explain wire initiation studies on the Sandia Z machine to increasing the predictive power of inertial confinement fusion modeling. The central goal or objective of our proposed research is to experimentally determine the electrical resistivity, temperature, density, and average ionization state of a variety of materials in the warm dense matter regime, without the use of theoretical calculations. Since the lack of an accurate energy of state (EOS) model is primarily due to the lack of experimental data, we propose an experimental study of the transport coefficients of warm dense matter.

  19. Study of Human Biochemical Parameters During and After Ramadan.

    Science.gov (United States)

    Kiyani, Mubin Mustafa; Memon, Aamir Raoof; Amjad, Mian Imran; Ameer, Muhammad Rifaqat; Sadiq, Muhammad; Mahmood, Tariq

    2017-02-01

    Ramadan fasting is obligatory for Muslims each year. They abstain from drinking, eating and intimate relationship between dawn and dusk during this month. Dietary restriction during Ramadan has various biochemical and physiological effects. It is shown to decrease the body weight, glucose and lipid profile. This study aims to analyze the changes in body weight, glucose and lipid profile during Ramadan in physiotherapy students in Pakistan. The study was conducted during June-July 2013 (Hijri year 1434). There were 80 students (50 males and 30 females) recruited in the experiment. They all were healthy adults between the age group of 18-24 (mean age 20.5) years. All subjects underwent a general physical examination and interview, and non-healthy subjects were excluded. On statistical analysis, quantitative data were expressed in terms of mean ± SD and a p value of ≤0.05 was believed statically significant. Paired t test was used to compare the variables. There was a little reduction in body weight (62.7 ± 8.8 vs. 62.3 ± 9.0; p value = 0.009) but a significant decline in glucose level (72.6 ± 12.5 vs. 57.9 ± 10.7; p value = 0.000), low-density lipoprotein level (2.9 ± 0.3 vs. 2.5 ± 0.3; p value = 0.000), total cholesterol (4.6 ± 0.4 vs. 4.2 ± 0.5; p value = 0.000) and triglycerides (1.4 ± 0.5 vs. 1.2 ± 0.5; p value = 0.000) was observed. Moreover, there was some reduction in high-density lipoprotein cholesterol level (1.2 ± 0.3 vs. 1.1 ± 0.3; p value = 0.045). This study shows that Ramadan fasting, a religious obligation for purification of body and soul, resulted in reduced body weight and a positive effect on glucose level and lipid profile.

  20. A Parameter Study of Large Fast Reactor Nuclear Explosion Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Wiesel, J R

    1969-02-15

    An IBM-code EEM (Explosive Excursion Model) has been developed for calculating the energy releases associated with the explosive disassembly of a large fast reactor following a superprompt critical condition. The assumed failure chain of events and the possible core collapse following a fuel meltdown give the input data and initial conditions, the most important of which is the reactivity insertion rate at the moment of the explosive core disassembly. The dependence of the energy releases on the reactivity insertion rate, the Doppler reactivity feedback, the power form factor and the core size have been studied. The model enables a quick estimation of conservative values of the destructive mechanical energy releases following a nuclear explosion and gives suggestions as to how to reduce or even avoid such excursions.

  1. A Parameter Study of Large Fast Reactor Nuclear Explosion Accidents

    International Nuclear Information System (INIS)

    Wiesel, J.R.

    1969-02-01

    An IBM-code EEM (Explosive Excursion Model) has been developed for calculating the energy releases associated with the explosive disassembly of a large fast reactor following a superprompt critical condition. The assumed failure chain of events and the possible core collapse following a fuel meltdown give the input data and initial conditions, the most important of which is the reactivity insertion rate at the moment of the explosive core disassembly. The dependence of the energy releases on the reactivity insertion rate, the Doppler reactivity feedback, the power form factor and the core size have been studied. The model enables a quick estimation of conservative values of the destructive mechanical energy releases following a nuclear explosion and gives suggestions as to how to reduce or even avoid such excursions

  2. Study on orthorhombic parameters for 3D elastic full waveform inversion

    KAUST Repository

    Oh, Juwon

    2015-08-21

    For a better understanding of the influence of the parameterizations on the multi-parameter full waveform inversion (FWI) for 3D elastic orthorhombic media, we analyze the virtual sources for each cij parameter. Because the virtual sources for cij parameters can be regarded as bases of the virtual sources for other parameterizations, the insights developed here explains many of the scattering phenomena of the different parameters. The resulting radiation patterns provide insights on which parameter set is the best in the multi-parameter FWI for 3D elastic orthorhombic media. In this study, we analyze the virtual source for each cij parameter as a linear combination of several moment tensors. After that, we analyze the strain fields deformed by incident waves as momenta of the virtual source and their influences on sensitivity kernels of each cij parameter.

  3. Study on orthorhombic parameters for 3D elastic full waveform inversion

    KAUST Repository

    Oh, Juwon; Alkhalifah, Tariq Ali

    2015-01-01

    For a better understanding of the influence of the parameterizations on the multi-parameter full waveform inversion (FWI) for 3D elastic orthorhombic media, we analyze the virtual sources for each cij parameter. Because the virtual sources for cij parameters can be regarded as bases of the virtual sources for other parameterizations, the insights developed here explains many of the scattering phenomena of the different parameters. The resulting radiation patterns provide insights on which parameter set is the best in the multi-parameter FWI for 3D elastic orthorhombic media. In this study, we analyze the virtual source for each cij parameter as a linear combination of several moment tensors. After that, we analyze the strain fields deformed by incident waves as momenta of the virtual source and their influences on sensitivity kernels of each cij parameter.

  4. Analysis of Combined Data from Heterogeneous Study Designs: A Methodological Proposal from the Patient Navigation Research program

    Science.gov (United States)

    Roetzheim, Richard G.; Freund, Karen M.; Corle, Don K.; Murray, David M.; Snyder, Frederick R.; Kronman, Andrea C.; Jean-Pierre, Pascal; Raich, Peter C.; Holden, Alan E. C.; Darnell, Julie S.; Warren-Mears, Victoria; Patierno, Steven; Design, PNRP; Committee, Analysis

    2013-01-01

    Background The Patient Navigation Research Program (PNRP) is a cooperative effort of nine research projects, each employing its own unique study design. To evaluate projects such as PNRP, it is desirable to perform a pooled analysis to increase power relative to the individual projects. There is no agreed upon prospective methodology, however, for analyzing combined data arising from different study designs. Expert opinions were thus solicited from members of the PNRP Design and Analysis Committee Purpose To review possible methodologies for analyzing combined data arising from heterogeneous study designs. Methods The Design and Analysis Committee critically reviewed the pros and cons of five potential methods for analyzing combined PNRP project data. Conclusions were based on simple consensus. The five approaches reviewed included: 1) Analyzing and reporting each project separately, 2) Combining data from all projects and performing an individual-level analysis, 3) Pooling data from projects having similar study designs, 4) Analyzing pooled data using a prospective meta analytic technique, 5) Analyzing pooled data utilizing a novel simulated group randomized design. Results Methodologies varied in their ability to incorporate data from all PNRP projects, to appropriately account for differing study designs, and in their impact from differing project sample sizes. Limitations The conclusions reached were based on expert opinion and not derived from actual analyses performed. Conclusions The ability to analyze pooled data arising from differing study designs may provide pertinent information to inform programmatic, budgetary, and policy perspectives. Multi-site community-based research may not lend itself well to the more stringent explanatory and pragmatic standards of a randomized controlled trial design. Given our growing interest in community-based population research, the challenges inherent in the analysis of heterogeneous study design are likely to become

  5. Analysis of combined data from heterogeneous study designs: an applied example from the patient navigation research program.

    Science.gov (United States)

    Roetzheim, Richard G; Freund, Karen M; Corle, Don K; Murray, David M; Snyder, Frederick R; Kronman, Andrea C; Jean-Pierre, Pascal; Raich, Peter C; Holden, Alan Ec; Darnell, Julie S; Warren-Mears, Victoria; Patierno, Steven

    2012-04-01

    The Patient Navigation Research Program (PNRP) is a cooperative effort of nine research projects, with similar clinical criteria but with different study designs. To evaluate projects such as PNRP, it is desirable to perform a pooled analysis to increase power relative to the individual projects. There is no agreed-upon prospective methodology, however, for analyzing combined data arising from different study designs. Expert opinions were thus solicited from the members of the PNRP Design and Analysis Committee. To review possible methodologies for analyzing combined data arising from heterogeneous study designs. The Design and Analysis Committee critically reviewed the pros and cons of five potential methods for analyzing combined PNRP project data. The conclusions were based on simple consensus. The five approaches reviewed included the following: (1) analyzing and reporting each project separately, (2) combining data from all projects and performing an individual-level analysis, (3) pooling data from projects having similar study designs, (4) analyzing pooled data using a prospective meta-analytic technique, and (5) analyzing pooled data utilizing a novel simulated group-randomized design. Methodologies varied in their ability to incorporate data from all PNRP projects, to appropriately account for differing study designs, and to accommodate differing project sample sizes. The conclusions reached were based on expert opinion and not derived from actual analyses performed. The ability to analyze pooled data arising from differing study designs may provide pertinent information to inform programmatic, budgetary, and policy perspectives. Multisite community-based research may not lend itself well to the more stringent explanatory and pragmatic standards of a randomized controlled trial design. Given our growing interest in community-based population research, the challenges inherent in the analysis of heterogeneous study design are likely to become more salient

  6. Study of relevant parameters of GEM-based detectors

    CERN Document Server

    Croci, Gabriele; Sauli, Fabio; Ragazzi, S

    2007-01-01

    The Gas Electron Multiplier consist of a thin Kapton insulating (50 $\\mu$m) foil copper-clad on both sides and perforated by a high density, regular matrix of holes (around 100 per square millimeter). Typically the distance between holes (pitch) is 140 $\\mu$m and diameters of about 70 $\\mu$m. The mesh is realised by conventional photolitographic methods as used for the fabrication of multi-layer board. Upon application of a potential difference between the GEM electrodes, a high dipole field develops in the holes focusing the field lines between the drift electrode and the readout element. Electron drift along the channel and the charge is amplified by a factor that depends on the field density and the length of the channel. Owing to their excellent position resolution and rate capability GEM-based detector are very suitable to be used in different applications: from the high energy physics to the medical field. The GEM temporal and rate gain stability was studied and it was discovered that the gain variation...

  7. Parameter study toward economical magnetic fusion power reactors

    International Nuclear Information System (INIS)

    Yoshida, Tomoaki; Okano, Kunihiko; Nanahara, Toshiya; Hatayama, Akiyoshi; Yamaji, Kenji; Takuma, Tadashi.

    1996-01-01

    Although the R and D of nuclear fusion reactors has made a steady progress as seen in ITER project, it has become of little doubt that fusion power reactors require hugeness and enormous amount of construction cost as well as surmounting the physics and engineering difficulties. Therefore, it is one of the essential issues to investigate the prospect of realizing fusion power reactors. In this report we investigated the effects of physics and engineering improvements on the economics of ITER-like steady state tokamak fusion reactors using our tokamak system and costing analysis code. With the results of this study, we considered what is the most significant factor for realizing economical competitive fusion reactors. The results show that with the conventional TF coil maximum field (12T), physics progress in β-value (or Troyon coefficient) has the most considerable effect on the reduction of fusion plant COE (Cost of Electricity) while the achievement of H factor = 2-3 and neutron wall load =∼5MW/m 2 is necessary. The results also show that with the improvement of TF coil maximum field, reactors with a high aspect ratio are economically advantageous because of low plasma current driving power while the improvement of current density in the conductors and yield strength of support structures is indispensable. (author)

  8. A Spatial Data Infrastructure Integrating Multisource Heterogeneous Geospatial Data and Time Series: A Study Case in Agriculture

    Directory of Open Access Journals (Sweden)

    Gloria Bordogna

    2016-05-01

    Full Text Available Currently, the best practice to support land planning calls for the development of Spatial Data Infrastructures (SDI capable of integrating both geospatial datasets and time series information from multiple sources, e.g., multitemporal satellite data and Volunteered Geographic Information (VGI. This paper describes an original OGC standard interoperable SDI architecture and a geospatial data and metadata workflow for creating and managing multisource heterogeneous geospatial datasets and time series, and discusses it in the framework of the Space4Agri project study case developed to support the agricultural sector in Lombardy region, Northern Italy. The main novel contributions go beyond the application domain for which the SDI has been developed and are the following: the ingestion within an a-centric SDI, potentially distributed in several nodes on the Internet to support scalability, of products derived by processing remote sensing images, authoritative data, georeferenced in-situ measurements and voluntary information (VGI created by farmers and agronomists using an original Smart App; the workflow automation for publishing sets and time series of heterogeneous multisource geospatial data and relative web services; and, finally, the project geoportal, that can ease the analysis of the geospatial datasets and time series by providing complex intelligent spatio-temporal query and answering facilities.

  9. High resolution field study of sediment dynamics on a strongly heterogeneous bed

    Science.gov (United States)

    Bailly Du Bois, P.; Blanpain, O.; Lafite, R.; Cugier, P.; Lunven, M.

    2010-12-01

    Extensive field measurements have been carried out at several stations in a macrotidal inner continental shelf in the English Channel (around 25 m depth) during spring tide period. The strong tidal current measured (up to 1.6 m.s-1) allowed sediment dynamics on a bed characterised by a mixture of size with coarse grains to be dominant. Data acquired in such hydro-sedimentary conditions are scarce. A new instrument, the DYnamic Sediment Profile Imagery (DySPI) system, was specifically conceived and implemented in-situ to observe and measure, with a high temporal resolution, the dynamics of a strongly heterogeneous mixture of particles in a grain-size scale. The data collected covered: 1) grain size range (side scan sonar, video observations, Shipeck grab samples, DySPI images) and vertical sorting (stratigraphic sampling by divers) of sediment cover, 2) hydrodynamic features (acoustic Doppler velocimeter, acoustic Doppler profiler), 3) suspended load nature and dynamics (optical backscatter, chlorophyll fluorometer, particle size analyser, Niskin bottles, scanning electron microscopy), 4) sand and gravel bedload transport estimates (DySPI image processing), 5) transfer dynamics of fine grains within a coarse matrix and their depth of penetration (radionuclides measurements in stratigraphic samples). The four stations present different grain size vertical sorting from a quasi-permanent armouring to a homogenous distribution. The sediment cover condition is directly linked to hydrodynamic capacity and sediment availability. Fine grain ratio within deep sediment layers (up to 10 cm) is higher when the bed armouring is durable. However, fine sediments are not permanently depth trapped: deep layers are composed of few years-old radionuclide tracers fixed on fine grains and a vertical mixing coefficient has been evaluated for each sediment cover. Fine grain dynamics within a coarse matrix is inversely proportional to the robustness of the armour layer. For current

  10. Multiple Kernel Learning for Heterogeneous Anomaly Detection: Algorithm and Aviation Safety Case Study

    Science.gov (United States)

    Das, Santanu; Srivastava, Ashok N.; Matthews, Bryan L.; Oza, Nikunj C.

    2010-01-01

    The world-wide aviation system is one of the most complex dynamical systems ever developed and is generating data at an extremely rapid rate. Most modern commercial aircraft record several hundred flight parameters including information from the guidance, navigation, and control systems, the avionics and propulsion systems, and the pilot inputs into the aircraft. These parameters may be continuous measurements or binary or categorical measurements recorded in one second intervals for the duration of the flight. Currently, most approaches to aviation safety are reactive, meaning that they are designed to react to an aviation safety incident or accident. In this paper, we discuss a novel approach based on the theory of multiple kernel learning to detect potential safety anomalies in very large data bases of discrete and continuous data from world-wide operations of commercial fleets. We pose a general anomaly detection problem which includes both discrete and continuous data streams, where we assume that the discrete streams have a causal influence on the continuous streams. We also assume that atypical sequence of events in the discrete streams can lead to off-nominal system performance. We discuss the application domain, novel algorithms, and also discuss results on real-world data sets. Our algorithm uncovers operationally significant events in high dimensional data streams in the aviation industry which are not detectable using state of the art methods

  11. Study of hydraulic parameters in leach mining using radioactive tracer

    International Nuclear Information System (INIS)

    Ahmad, M.; Tariq, J.A.; Iqbal, N.; Rafiq, M.

    2002-01-01

    Six radioactive tracer (/sup 131/I) experiments were carried out at in-situ leach mining site to study transit time of injected fluid from the injection wells to the production well along the dip, against the dip, along the diagonals and the strike. It was found that the dip of the host sandstone does not affect the movement of fluid as the same velocity was found along the dip (0.23 m/h) and against the dip (0.22 m/h). Along the diagonals, the breakthrough times for 13.75 m and 16.25 m were 54 hours and 155 hours respectively yielding velocities of 0.26 m/h and 0.1 m/h. The higher velocity is not only due to shorter distance but also due to higher porosity / injection rate. Along the strike, the breakthrough time was 29 hours (very short) for 9.25 m distance and 147 hours for 16.25 m distance. The unexpectedly high velocity along the strike for shorter distance was also due to higher injection rate in the well as the other well was accepting only small fraction of the total injection. At higher injection/production rate or higher hydraulic gradient, the breakthrough time is shorter and also the dispersion of fluid is less, consequently the leach area would be relatively small. Fluctuations of activity in some cases show the presence of fractures/cracks at certain places in the strata. The estimated porosity and hydraulic conductivity of the aquifer are 28% and 1.23 x 10-5 m/s respectively. (author)

  12. Effect of tissue heterogeneity on quantification in positron emission tomography

    International Nuclear Information System (INIS)

    Blomqvist, G.; Lammertsma, A.A.; Mazoyer, B.; Wienhard, K.

    1995-01-01

    As a result of the limited spatial resolution of positron emission tomographic scanners, the measurements of physiological parameters are compromised by tissue heterogeneity. The effect of tissue heterogeneity on a number of parameters was studied by simulation and an analytical method. Five common tracer models were assessed. The input and tissue response functions were assumed to be free from noise and systematic errors. The kinetic model was assumed to be perfect. Two components with different kinetics were mixed in different proportions and contrast with respect to the model parameters. Different experimental protocols were investigated. Of three methods investigated for the measurement of cerebral blood flow (CBF) (steady state, dynamic, integral), the second one was least sensitive to errors caused by tissue heterogeneity and the main effect was an underestimation of the distribution volume. With the steady state method, errors in oxygen extraction fraction caused by tissue heterogeneity were always found to be less than the corresponding errors in CBF. For myocardial blood flow the steady state method was found to perform better than the bolus method. The net accumulation of substrate (i.e. rCMR glc in the case of glucose analogs) was found to be comparatively insensitive to tissue heterogeneity. Individual rate constans such as k 2 and k 3 for efflux and metabolism of the substrate in the pool of unmetabolized substrate in the tissue, respectively, were found to be more sensitive. In studies of radioligand binding, using only tracer doses, the effect of tissue heterogeneity on the parameter k on .B max could be considerable. In studies of radioligand binding using a protocol with two experiments, one with high and one with low specific activity, B max was found to be insensitive while K d was very sensitive to tissue heterogeneity. (orig.)

  13. Effect of tissue heterogeneity on quantification in positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Blomqvist, G [Dept. of Clinical Neuroscience, Experimental Alcohol and Drug Addiction Research Section, Karolinska Hospital, Stockholm (Sweden); Lammertsma, A A [PET Methodology Group, Cyclotron Unit, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom); Mazoyer, B [Service Hospitalier Frederic Joliot CEA/Dept. de Biologie, Hopital d` Orsay and Antenne d` Informatique Medicale, Hopital Robert Debre, Paris (France); Wienhard, K [Max-Planck-Inst. fuer Neurologische Forschung, Koeln (Germany)

    1995-07-01

    As a result of the limited spatial resolution of positron emission tomographic scanners, the measurements of physiological parameters are compromised by tissue heterogeneity. The effect of tissue heterogeneity on a number of parameters was studied by simulation and an analytical method. Five common tracer models were assessed. The input and tissue response functions were assumed to be free from noise and systematic errors. The kinetic model was assumed to be perfect. Two components with different kinetics were mixed in different proportions and contrast with respect to the model parameters. Different experimental protocols were investigated. Of three methods investigated for the measurement of cerebral blood flow (CBF) (steady state, dynamic, integral), the second one was least sensitive to errors caused by tissue heterogeneity and the main effect was an underestimation of the distribution volume. With the steady state method, errors in oxygen extraction fraction caused by tissue heterogeneity were always found to be less than the corresponding errors in CBF. For myocardial blood flow the steady state method was found to perform better than the bolus method. The net accumulation of substrate (i.e. rCMR{sub glc} in the case of glucose analogs) was found to be comparatively insensitive to tissue heterogeneity. Individual rate constans such as k{sub 2} and k{sub 3} for efflux and metabolism of the substrate in the pool of unmetabolized substrate in the tissue, respectively, were found to be more sensitive. In studies of radioligand binding, using only tracer doses, the effect of tissue heterogeneity on the parameter k{sub on}.B{sub max} could be considerable. In studies of radioligand binding using a protocol with two experiments, one with high and one with low specific activity, B{sub max} was found to be insensitive while K{sub d} was very sensitive to tissue heterogeneity. (orig.)

  14. Finite size and geometrical non-linear effects during crack pinning by heterogeneities: An analytical and experimental study

    Science.gov (United States)

    Vasoya, Manish; Unni, Aparna Beena; Leblond, Jean-Baptiste; Lazarus, Veronique; Ponson, Laurent

    2016-04-01

    Crack pinning by heterogeneities is a central toughening mechanism in the failure of brittle materials. So far, most analytical explorations of the crack front deformation arising from spatial variations of fracture properties have been restricted to weak toughness contrasts using first order approximation and to defects of small dimensions with respect to the sample size. In this work, we investigate the non-linear effects arising from larger toughness contrasts by extending the approximation to the second order, while taking into account the finite sample thickness. Our calculations predict the evolution of a planar crack lying on the mid-plane of a plate as a function of material parameters and loading conditions, especially in the case of a single infinitely elongated obstacle. Peeling experiments are presented which validate the approach and evidence that the second order term broadens its range of validity in terms of toughness contrast values. The work highlights the non-linear response of the crack front to strong defects and the central role played by the thickness of the specimen on the pinning process.

  15. Parameter study on infilled steel frames with discretely connected precast concrete panels

    NARCIS (Netherlands)

    Teeuwen, P.A.; Kleinman, C.S.; Snijder, H.H.; Hofmeyer, H.; Chan, S.L.

    2009-01-01

    This paper presents a parameter study on infilled steel frames with discretely connected precast concrete infill panels having window openings. In this study, finite element simulations were carried out to study the infilled frame performance by varying several parameters. A recently developed

  16. Isotopes in heterogeneous catalysis

    CERN Document Server

    Hargreaves, Justin SJ

    2006-01-01

    The purpose of this book is to review the current, state-of-the-art application of isotopic methods to the field of heterogeneous catalysis. Isotopic studies are arguably the ultimate technique in in situ methods for heterogeneous catalysis. In this review volume, chapters have been contributed by experts in the field and the coverage includes both the application of specific isotopes - Deuterium, Tritium, Carbon-14, Sulfur-35 and Oxygen-18 - as well as isotopic techniques - determination of surface mobility, steady state transient isotope kinetic analysis, and positron emission profiling.

  17. Heterogeneous Active Matter

    Science.gov (United States)

    Kolb, Thomas; Klotsa, Daphne

    Active systems are composed of self-propelled (active) particles that locally convert energy into motion and exhibit emergent collective behaviors, such as fish schooling and bird flocking. Most works so far have focused on monodisperse, one-component active systems. However, real systems are heterogeneous, and consist of several active components. We perform molecular dynamics simulations of multi-component active matter systems and report on their emergent behavior. We discuss the phase diagram of dynamic states as well as parameters where we see mixing versus segregation.

  18. Numerical analysis for Darcy-Forchheimer flow in presence of homogeneous-heterogeneous reactions

    Directory of Open Access Journals (Sweden)

    Muhammad Ijaz Khan

    Full Text Available A mathematical study is presented to investigate the influences of homogeneous and heterogeneous reactions in local similar flow caused by stretching sheet with a non-linear velocity and variable thickness. Porous medium effects are characterized by using Darcy-Forchheimer porous-media. A simple isothermal model of homogeneous-heterogeneous reactions is used. The multiphysical boundary value problem is dictated by ten thermophysical parameters: ratio of mass diffusion coefficients, Prandtl number, local inertia coefficient parameter, inverse Darcy number, shape parameter, surface thickness parameter, Hartman number, Homogeneous heat reaction, strength of homogeneous-heterogeneous reactions and Schmidt number. Resulting systems are computed by Runge-Kutta-Fehlberg method. Different shapes of velocity are noticed for n > 1 and n < 1. Keywords: Homogeneous-heterogeneous reactions, Non Darcy porous medium, Variable sheet thickness, Homogeneous heat reaction with stoichiometric coefficient, Runge-Kutta-Fehlberg method

  19. Large epidemic thresholds emerge in heterogeneous networks of heterogeneous nodes

    Science.gov (United States)

    Yang, Hui; Tang, Ming; Gross, Thilo

    2015-08-01

    One of the famous results of network science states that networks with heterogeneous connectivity are more susceptible to epidemic spreading than their more homogeneous counterparts. In particular, in networks of identical nodes it has been shown that network heterogeneity, i.e. a broad degree distribution, can lower the epidemic threshold at which epidemics can invade the system. Network heterogeneity can thus allow diseases with lower transmission probabilities to persist and spread. However, it has been pointed out that networks in which the properties of nodes are intrinsically heterogeneous can be very resilient to disease spreading. Heterogeneity in structure can enhance or diminish the resilience of networks with heterogeneous nodes, depending on the correlations between the topological and intrinsic properties. Here, we consider a plausible scenario where people have intrinsic differences in susceptibility and adapt their social network structure to the presence of the disease. We show that the resilience of networks with heterogeneous connectivity can surpass those of networks with homogeneous connectivity. For epidemiology, this implies that network heterogeneity should not be studied in isolation, it is instead the heterogeneity of infection risk that determines the likelihood of outbreaks.

  20. Large epidemic thresholds emerge in heterogeneous networks of heterogeneous nodes.

    Science.gov (United States)

    Yang, Hui; Tang, Ming; Gross, Thilo

    2015-08-21

    One of the famous results of network science states that networks with heterogeneous connectivity are more susceptible to epidemic spreading than their more homogeneous counterparts. In particular, in networks of identical nodes it has been shown that network heterogeneity, i.e. a broad degree distribution, can lower the epidemic threshold at which epidemics can invade the system. Network heterogeneity can thus allow diseases with lower transmission probabilities to persist and spread. However, it has been pointed out that networks in which the properties of nodes are intrinsically heterogeneous can be very resilient to disease spreading. Heterogeneity in structure can enhance or diminish the resilience of networks with heterogeneous nodes, depending on the correlations between the topological and intrinsic properties. Here, we consider a plausible scenario where people have intrinsic differences in susceptibility and adapt their social network structure to the presence of the disease. We show that the resilience of networks with heterogeneous connectivity can surpass those of networks with homogeneous connectivity. For epidemiology, this implies that network heterogeneity should not be studied in isolation, it is instead the heterogeneity of infection risk that determines the likelihood of outbreaks.

  1. Heterogeneity of Dutch rainfall

    NARCIS (Netherlands)

    Witter, J.V.

    1984-01-01

    Rainfall data for the Netherlands have been used in this study to investigate aspects of heterogeneity of rainfall, in particular local differences in rainfall levels, time trends in rainfall, and local differences in rainfall trend. The possible effect of urbanization and industrialization on the

  2. Why does heterogeneity matter?

    Science.gov (United States)

    K.B. Pierce

    2007-01-01

    This is a review of the book "Ecosystem function in heterogeneous landscapes" published in 2005. The authors are G. Lovett, C. Jones, M.G. Turner, and K.C. Weathers. It was published by Springer, New York. The book is a synthesis of the 10th Gary conference held at the Institute of Ecosystem Studies in Millbrook, New York, in 2003.

  3. Normalization of Phenotypic Data from a Clinical Data Warehouse: Case Study of Heterogeneous Blood Type Data with Surprising Results.

    Science.gov (United States)

    Cimino, James J

    2015-01-01

    Clinical data warehouses often contain analogous data from disparate sources, resulting in heterogeneous formats and semantics. We have developed an approach that attempts to represent such phenotypic data in its most atomic form to facilitate aggregation. We illustrate this approach with human blood antigen typing (ABO-Rh) data drawn from the National Institutes of Health's Biomedical Translational Research Information System (BTRIS). In applying the method to actual patient data, we discovered a 2% incidence of changed blood types. We believe our approach can be applied to any institution's data to obtain comparable patient phenotypes. The actual discrepant blood type data will form the basis for a future study of the reasons for blood typing variation.

  4. Heterogeneous burnable poisons. Sinterability study in oxidizing atmosphere of alumina-gadolinia and alumina-boron carbide compounds

    International Nuclear Information System (INIS)

    Agueda, H.C.; Leiva, S.F.; Russo, D.O.

    1990-01-01

    Solid burnable poisons are used in reactors cooled by pressure light water (PLWR) with the purpose of controlling initial reactivity in the first reactor's core. The burnable poisons may be uniformly mixed with the fuel -known as 'homogeneous' poisons-; or constituting separate elements -known as heterogeneous poisons-. The purpose of this work is to present the results of two sinterability studies, performed on Al 2 O 3 -Gd 2 O 3 and Al 2 O 3 -B 4 C, where alumina acts as inert matrix, storing the absorbing elements as Gd 2 O 3 or B 4 C. The elements were sintered at an air atmosphere and additives permitting the obtention of a greater density alumina were tested at lower temperatures than the characteristic for this material, in order to determine its compatibility with the materials dealt with herein. (Author) [es

  5. Predictive Big Data Analytics: A Study of Parkinson’s Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

    Science.gov (United States)

    Dinov, Ivo D.; Heavner, Ben; Tang, Ming; Glusman, Gustavo; Chard, Kyle; Darcy, Mike; Madduri, Ravi; Pa, Judy; Spino, Cathie; Kesselman, Carl; Foster, Ian; Deutsch, Eric W.; Price, Nathan D.; Van Horn, John D.; Ames, Joseph; Clark, Kristi; Hood, Leroy; Hampstead, Benjamin M.; Dauer, William; Toga, Arthur W.

    2016-01-01

    Background A unique archive of Big Data on Parkinson’s Disease is collected, managed and disseminated by the Parkinson’s Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationship of Parkinson’s disease (PD) risk to trauma, genetics, environment, co-morbidities, or life style. The defining characteristics of Big Data–large size, incongruency, incompleteness, complexity, multiplicity of scales, and heterogeneity of information-generating sources–all pose challenges to the classical techniques for data management, processing, visualization and interpretation. We propose, implement, test and validate complementary model-based and model-free approaches for PD classification and prediction. To explore PD risk using Big Data methodology, we jointly processed complex PPMI imaging, genetics, clinical and demographic data. Methods and Findings Collective representation of the multi-source data facilitates the aggregation and harmonization of complex data elements. This enables joint modeling of the complete data, leading to the development of Big Data analytics, predictive synthesis, and statistical validation. Using heterogeneous PPMI data, we developed a comprehensive protocol for end-to-end data characterization, manipulation, processing, cleaning, analysis and validation. Specifically, we (i) introduce methods for rebalancing imbalanced cohorts, (ii) utilize a wide spectrum of classification methods to generate consistent and powerful phenotypic predictions, and (iii) generate reproducible machine-learning based classification that enables the reporting of model parameters and diagnostic forecasting based on new data. We evaluated several

  6. CSF biomarkers associated with disease heterogeneity in early Parkinson’s disease: the Parkinson’s Progression Markers Initiative study

    Science.gov (United States)

    Kang, Ju-Hee; Mollenhauer, Brit; Coffey, Christopher S.; Toledo, Jon B.; Weintraub, Daniel; Galasko, Douglas R.; Irwin, David J.; Van Deerlin, Vivianna; Chen-Plotkin, Alice S.; Caspell-Garcia, Chelsea; Waligórska, Teresa; Taylor, Peggy; Shah, Nirali; Pan, Sarah; Zero, Pawel; Frasier, Mark; Marek, Kenneth; Kieburtz, Karl; Jennings, Danna; Tanner, Caroline M.; Simuni, Tanya; Singleton, Andrew; Toga, Arthur W.; Chowdhury, Sohini; Trojanowski, John Q.; Shaw, Leslie M.

    2016-01-01

    The development of biomarkers to predict the progression of Parkinson’s disease (PD) from its earliest stage through its heterogeneous course is critical for research and therapeutic development. The Parkinson’s Progression Markers Initiative (PPMI) study is an ongoing international multicenter, prospective study to validate biomarkers in drug-naïve PD patients and matched healthy controls (HC). We quantified cerebrospinal fluid (CSF) alpha-synuclein (α-syn), amyloid-beta1–42 (Aβ1–42), total tau (t-tau), and tau phosphorylated at Thr181 (p-tau) in 660 PPMI subjects at baseline, and correlated these data with measures of the clinical features of these subjects. We found that CSF α-syn, t-tau and p-tau levels, but not Aβ1–42, were significantly lower in PD compared with HC, while the diagnostic value of the individual CSF biomarkers for PD diagnosis was limited due to large overlap. The level of α-syn, but not other biomarkers, was significantly lower in PD patients with non-tremor-dominant phenotype compared with tremor-dominant phenotype. In addition, in PD patients the lowest Aβ1–42, or highest t-tau/Aβ1–42 and t-tau/α-syn quintile in PD patients were associated with more severe non-motor dysfunction compared with the highest or lowest quintiles, respectively. In a multivariate regression model, lower α-syn was significantly associated with worse cognitive test performance. APOE ε4 genotype was associated with lower levels of Aβ1–42, but neither with PD diagnosis nor cognition. Our data suggest that the measurement of CSF biomarkers in early-stage PD patients may relate to disease heterogeneity seen in PD. Longitudinal observations in PPMI subjects are needed to define their prognostic performance. PMID:27021906

  7. Heterogeneity in the Fault Damage Zone: a Field Study on the Borrego Fault, B.C., Mexico

    Science.gov (United States)

    Ostermeijer, G.; Mitchell, T. M.; Dorsey, M. T.; Browning, J.; Rockwell, T. K.; Aben, F. M.; Fletcher, J. M.; Brantut, N.

    2017-12-01

    The nature and distribution of damage around faults, and its impacts on fault zone properties has been a hot topic of research over the past decade. Understanding the mechanisms that control the formation of off fault damage can shed light on the processes during the seismic cycle, and the nature of fault zone development. Recent published work has identified three broad zones of damage around most faults based on the type, intensity, and extent of fracturing; Tip, Wall, and Linking damage. Although these zones are able to adequately characterise the general distribution of damage, little has been done to identify the nature of damage heterogeneity within those zones, often simplifying the distribution to fit log-normal linear decay trends. Here, we attempt to characterise the distribution of fractures that make up the wall damage around seismogenic faults. To do so, we investigate an extensive two dimensional fracture network exposed on a river cut platform along the Borrego Fault, BC, Mexico, 5m wide, and extending 20m from the fault core into the damage zone. High resolution fracture mapping of the outcrop, covering scales ranging three orders of magnitude (cm to m), has allowed for detailed observations of the 2D damage distribution within the fault damage zone. Damage profiles were obtained along several 1D transects perpendicular to the fault and micro-damage was examined from thin-sections at various locations around the outcrop for comparison. Analysis of the resulting fracture network indicates heterogeneities in damage intensity at decimetre scales resulting from a patchy distribution of high and low intensity corridors and clusters. Such patchiness may contribute to inconsistencies in damage zone widths defined along 1D transects and the observed variability of fracture densities around decay trends. How this distribution develops with fault maturity and the scaling of heterogeneities above and below the observed range will likely play a key role in

  8. in Heterogeneous Media

    Directory of Open Access Journals (Sweden)

    Saeed Balouchi

    2013-01-01

    Full Text Available Fractured reservoirs contain about 85 and 90 percent of oil and gas resources respectively in Iran. A comprehensive study and investigation of fractures as the main factor affecting fluid flow or perhaps barrier seems necessary for reservoir development studies. High degrees of heterogeneity and sparseness of data have incapacitated conventional deterministic methods in fracture network modeling. Recently, simulated annealing (SA has been applied to generate stochastic realizations of spatially correlated fracture networks by assuming that the elastic energy of fractures follows Boltzmann distribution. Although SA honors local variability, the objective function of geometrical fracture modeling is defined for homogeneous conditions. In this study, after the introduction of SA and the derivation of the energy function, a novel technique is presented to adjust the model with highly heterogeneous data for a fractured field from the southwest of Iran. To this end, the regular object-based model is combined with a grid-based technique to cover the heterogeneity of reservoir properties. The original SA algorithm is also modified by being constrained in different directions and weighting the energy function to make it appropriate for heterogeneous conditions. The simulation results of the presented approach are in good agreement with the observed field data.

  9. Reproducibility of preclinical animal research improves with heterogeneity of study samples

    Science.gov (United States)

    Vogt, Lucile; Sena, Emily S.; Würbel, Hanno

    2018-01-01

    Single-laboratory studies conducted under highly standardized conditions are the gold standard in preclinical animal research. Using simulations based on 440 preclinical studies across 13 different interventions in animal models of stroke, myocardial infarction, and breast cancer, we compared the accuracy of effect size estimates between single-laboratory and multi-laboratory study designs. Single-laboratory studies generally failed to predict effect size accurately, and larger sample sizes rendered effect size estimates even less accurate. By contrast, multi-laboratory designs including as few as 2 to 4 laboratories increased coverage probability by up to 42 percentage points without a need for larger sample sizes. These findings demonstrate that within-study standardization is a major cause of poor reproducibility. More representative study samples are required to improve the external validity and reproducibility of preclinical animal research and to prevent wasting animals and resources for inconclusive research. PMID:29470495

  10. Theoretical Studies in Heterogenous Catalysis: Towards a Rational Design of Novel Catalysts for Hydrodesulfurization and Hydrogen Production

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez,J.A.; Liu, P.

    2008-10-01

    Traditionally, knowledge in heterogeneous catalysis has come through empirical research. Nowadays, there is a clear interest to change this since millions of dollars in products are generated every year in the chemical and petrochemical industries through catalytic processes. To obtain a fundamental knowledge of the factors that determine the activity of heterogeneous catalysts is a challenge for modern science since many of these systems are very complex in nature. In principle, when a molecule adsorbs on the surface of a heterogeneous catalyst, it can interact with a large number of bonding sites. It is known that the chemical properties of these bonding sites depend strongly on the chemical environment around them. Thus, there can be big variations in chemical reactivity when going from one region to another in the surface of a heterogeneous catalyst. A main objective is to understand how the structural and electronic properties of a surface affect the energetics for adsorption processes and the paths for dissociation and chemical reactions. In recent years, advances in instrumentation and experimental procedures have allowed a large series of detailed works on the surface chemistry of heterogeneous catalysts. In many cases, these experimental studies have shown interesting and unique phenomena. Theory is needed to unravel the basic interactions behind these phenomena and to provide a general framework for the interpretation of experimental results. Ideally, theoretical calculations based on density-functional theory have evolved to the point that one should be able to predict patterns in the activity of catalytic surfaces. As in the case of experimental techniques, no single theoretical approach is able to address the large diversity of phenomena occurring on a catalyst. Catalytic surfaces are usually modeled using either a finite cluster or a two-dimensionally periodic slab. Many articles have been published comparing the results of these two approaches. An

  11. The effect of intra-trappean heterogeneities on seismic data: A case study from the Deccan Traps

    Science.gov (United States)

    Pandey, Dhananjai; Singh, Satish; Sinha, Martin; MacGregor, Lucy

    2007-09-01

    Hydrocarbon exploration interests have renewed the need for developing new sub basalt imaging techniques. One of the most important problems encountered today is seismic imaging below basalt. In recent years, this problem appears to have been overcome partly by using long offset seismic data. However near offset data are yet to be fully utilised due to the complex waveform caused by the surface as well as internal heterogeneity of the basalts. The near normal incidence data, which influence the sub-basalt imaging, are highly useful to understand the internal structure within a basalt layer. The use of converted waves for such targets has been proposed as an alternative in a rather homogeneous basalt layer. With a few synthetic modelling exercises here we highlight the practical difficulties in dealing with more realistic and heterogeneous basalt flow. Full waveform seismograms are computed to understand the effects of intra-trappean sediments on the seismic data. A case study from the Deccan Traps of India is presented in this paper. First, we discuss the effects of intercalated sediments on the overall seismic image. Later, the sonic log data from the field are used to compute the full wave-field response using the reflectivity method and compared with the field data. The feasibility of using mode converted waves (P to S and vice-versa at the top and bottom basalt interfaces) for sub-basalt imaging in Kutch region is discussed through a series of velocity-depth profiles. By comparing with the field data we demonstrate that the effects of multiple thin layering within the basalt can strongly deteriorate the image we seek to interpret and exploit.

  12. Spatial heterogeneity of the relation between resting-state connectivity and blood flow: an important consideration for pharmacological studies.

    Science.gov (United States)

    Khalili-Mahani, Najmeh; van Osch, Matthias J; de Rooij, Mark; Beckmann, Christian F; van Buchem, Mark A; Dahan, Albert; van Gerven, Johannes M; Rombouts, Serge A R B

    2014-03-01

    Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations--mostly in the blood oxygen level dependent (BOLD) signal--across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting-state-network consistency (RSNC)--representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)--in a crossover placebo-controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug-by-time, time, drug and physiological rates) and each of these metrics. The drug-by-time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post-hoc voxel-wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Copyright © 2012 Wiley Periodicals, Inc.

  13. Studies of Heterogeneous and Diffusion-Influenced Nucleation for Improved Processing of Nanostructural Materials

    National Research Council Canada - National Science Library

    Kellon, Kenneth F; Buhro, William E

    2005-01-01

    .... The purpose of this grant was to identify a suitable glass for studies of the nucleation processes leading to nanostructure formation and to investigate the possibility of using TiB2 for enhanced...

  14. Heterogeneity in development of adolescent anxiety disorder symptoms in an 8-year longitudinal community study

    NARCIS (Netherlands)

    Nelemans, S.A.; Hale, W.W.; Branje, S.J.T.; Raaijmakers, Q.A.W.; Frijns, T.; van Lier, P.A.C.; Meeus, W.H.J.

    2014-01-01

    In this study, we prospectively examined developmental trajectories of five anxiety disorder symptom dimensions (generalized anxiety disorder, panic disorder, school anxiety, separation anxiety disorder, and social anxiety disorder) from early to late adolescence in a community sample of 239

  15. Cyriax's deep friction massage application parameters: Evidence from a cross-sectional study with physiotherapists.

    Science.gov (United States)

    Chaves, Paula; Simões, Daniela; Paço, Maria; Pinho, Francisco; Duarte, José Alberto; Ribeiro, Fernando

    2017-12-01

    Deep friction massage is one of several physiotherapy interventions suggested for the management of tendinopathy. To determine the prevalence of deep friction massage use in clinical practice, to characterize the application parameters used by physiotherapists, and to identify empirical model-based patterns of deep friction massage application in degenerative tendinopathy. observational, analytical, cross-sectional and national web-based survey. 478 physiotherapists were selected through snow-ball sampling method. The participants completed an online questionnaire about personal and professional characteristics as well as specific questions regarding the use of deep friction massage. Characterization of deep friction massage parameters used by physiotherapists were presented as counts and proportions. Latent class analysis was used to identify the empirical model-based patterns. Crude and adjusted odds ratios and 95% confidence intervals were computed. The use of deep friction massage was reported by 88.1% of the participants; tendinopathy was the clinical condition where it was most frequently used (84.9%) and, from these, 55.9% reported its use in degenerative tendinopathy. The "duration of application" parameters in chronic phase and "frequency of application" in acute and chronic phases are those that diverge most from those recommended by the author of deep friction massage. We found a high prevalence of deep friction massage use, namely in degenerative tendinopathy. Our results have shown that the application parameters are heterogeneous and diverse. This is reflected by the identification of two application patterns, although none is in complete agreement with Cyriax's description. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies

    Science.gov (United States)

    2014-01-01

    Expression quantitative trait loci (eQTL) mapping is a tool that can systematically identify genetic variation affecting gene expression. eQTL mapping studies have shown that certain genomic locations, referred to as regulatory hotspots, may affect the expression levels of many genes. Recently, studies have shown that various confounding factors may induce spurious regulatory hotspots. Here, we introduce a novel statistical method that effectively eliminates spurious hotspots while retaining genuine hotspots. Applied to simulated and real datasets, we validate that our method achieves greater sensitivity while retaining low false discovery rates compared to previous methods. PMID:24708878

  17. Comparative study for different statistical models to optimize cutting parameters of CNC end milling machines

    International Nuclear Information System (INIS)

    El-Berry, A.; El-Berry, A.; Al-Bossly, A.

    2010-01-01

    In machining operation, the quality of surface finish is an important requirement for many work pieces. Thus, that is very important to optimize cutting parameters for controlling the required manufacturing quality. Surface roughness parameter (Ra) in mechanical parts depends on turning parameters during the turning process. In the development of predictive models, cutting parameters of feed, cutting speed, depth of cut, are considered as model variables. For this purpose, this study focuses on comparing various machining experiments which using CNC vertical machining center, work pieces was aluminum 6061. Multiple regression models are used to predict the surface roughness at different experiments.

  18. A Study of Hydraulic Properties in a Single Fracture with In-plane Heterogeneity: An Evaluation Using Optical Measurements of a Transparent Replica

    Energy Technology Data Exchange (ETDEWEB)

    Sawada, Atsushi; Ssto, Hisashi [Japan Atomic Energy Agency, Ibaraki (Japan)

    2010-02-15

    Experimental examinations for evaluating fractures were conducted by using transparent replicas of a single fracture in order to obtain the fracture data to contribute to the methodology on how to improve the definition of representative parameter values used for a parallel plate fracture model. Quantitative aperture distribution and quantitative tracer concentration data at each point in time were obtained by measuring the attenuation of transmitted light through the fracture in high spatial resolution. The representative aperture values evaluated from the multiple different measurement methods, such as arithmetic mean of aperture distribution measured by the optical method, transport aperture evaluated from the tracer test, and average aperture evaluated from the fracture void volume measurement converged to a unique value that indicates the accuracy of this experimental study. The aperture data was employed for verifying the numerical simulation under the assumption of Local Cubic Law and showed that the calculated flow rate through the fracture is 10% . 100% larger than hydraulic test results. The quantitative tracer concentration data is also very valuable for validating existing numerical code for advection dispersion transport in-plane heterogeneous fractures

  19. A Study of Hydraulic Properties in a Single Fracture with In-plane Heterogeneity: An Evaluation Using Optical Measurements of a Transparent Replica

    International Nuclear Information System (INIS)

    Sawada, Atsushi; Ssto, Hisashi

    2010-01-01

    Experimental examinations for evaluating fractures were conducted by using transparent replicas of a single fracture in order to obtain the fracture data to contribute to the methodology on how to improve the definition of representative parameter values used for a parallel plate fracture model. Quantitative aperture distribution and quantitative tracer concentration data at each point in time were obtained by measuring the attenuation of transmitted light through the fracture in high spatial resolution. The representative aperture values evaluated from the multiple different measurement methods, such as arithmetic mean of aperture distribution measured by the optical method, transport aperture evaluated from the tracer test, and average aperture evaluated from the fracture void volume measurement converged to a unique value that indicates the accuracy of this experimental study. The aperture data was employed for verifying the numerical simulation under the assumption of Local Cubic Law and showed that the calculated flow rate through the fracture is 10% . 100% larger than hydraulic test results. The quantitative tracer concentration data is also very valuable for validating existing numerical code for advection dispersion transport in-plane heterogeneous fractures

  20. A Catalytically Active Membrane Reactor for Fast, Highly Exothermic, Heterogeneous Gas Reactions. A Pilot Plant Study

    NARCIS (Netherlands)

    Veldsink, Jan W.; Versteeg, Geert F.; Swaaij, Wim P.M. van

    1995-01-01

    Membrane reactors have been frequently studied because of their ability to combine chemical activity and separation properties into one device. Due to their thermal stability and mechanical strength, ceramic membranes are preferred over polymeric ones, but small transmembrane fluxes obstruct a

  1. Genetic Heterogeneity between the Three Components of the Autism Spectrum: A Twin Study

    Science.gov (United States)

    Ronald, Angelica; Happe, Francesca; Bolton, Patrick; Butcher, Lee M.; Price, Thomas S.; Wheelwright, Sally; Baron-Cohen, Simon; Plomin, Robert

    2006-01-01

    Objective: This study investigated the etiology of autistic-like traits in the general population and the etiological overlap between the three aspects of the triad of impairments (social impairments, communication impairments, restricted repetitive behaviors and interests) that together define autism spectrum disorders. Method: Parents of 3,400…

  2. A catalytically membrane reactor for fast, highly exothermic, heterogeneous gas reactions : a pilot plant study

    NARCIS (Netherlands)

    Veldsink, J.W.; Veldsink, J.W.; Versteeg, Geert; van Swaaij, Willibrordus Petrus Maria

    1995-01-01

    Membrane reactors have been frequently studied because of their ability to combine chemical activity and separation properties into one device. Due to their thermal stability and mechanical strength, ceramic membranes are preferred over polymeric ones, but small transmembrane fluxes obstruct a

  3. A study on the boiler efficiency influenced by the boiler operation parameter in fossil power plant

    International Nuclear Information System (INIS)

    Kwon, Y. S.; Suh, J. S.

    2002-01-01

    The main reason to analyze the boiler operation parameter in fossil power plant is to increase boiler high efficiency and energy saving movement in the government. This study intends to have trend and analyze the boiler efficiency influenced by the boiler parameter in sub-critical and super-critical type boiler

  4. A study on the microstructural parameters of 550 keV electron irradiated Lexan polymer films

    International Nuclear Information System (INIS)

    Hareesh, K.; Pramod, R.; Petwal, V. C.; Dwivedi, Jishnu; Sangappa; Sanjeev, Ganesh

    2012-01-01

    Lexan polymer films irradiated with 550 keV Electron Beam (EB) were characterized using Wide Angle Xray Scattering (WAXS) data to study the microstructural parameters. The crystal imperfection parameters like crystal size , lattice strain (g in %) and enthalpy (α) have been determined by Line Profile Analysis (LPA) using Fourier method of Warren.

  5. Heterogeneity, histological features and DNA ploidy in oral carcinoma by image-based analysis.

    Science.gov (United States)

    Diwakar, N; Sperandio, M; Sherriff, M; Brown, A; Odell, E W

    2005-04-01

    Oral squamous carcinomas appear heterogeneous on DNA ploidy analysis. However, this may be partly a result of sample dilution or the detection limit of techniques. The aim of this study was to determine whether oral squamous carcinomas are heterogeneous for ploidy status using image-based ploidy analysis and to determine whether ploidy status correlates with histological parameters. Multiple samples from 42 oral squamous carcinomas were analysed for DNA ploidy using an image-based system and scored for histological parameters. 22 were uniformly aneuploid, 1 uniformly tetraploid and 3 uniformly diploid. 16 appeared heterogeneous but only 8 appeared to be genuinely heterogeneous when minor ploidy histogram peaks were taken into account. Ploidy was closely related to nuclear pleomorphism but not differentiation. Sample variation, detection limits and diagnostic criteria account for much of the ploidy heterogeneity observed. Confident diagnosis of diploid status in an oral squamous cell carcinoma requires a minimum of 5 samples.

  6. Heterogeneous Network Evolution Studies for a Dense Urban High Rise Scenario

    DEFF Research Database (Denmark)

    Sanchez, Maria Laura Luque; Maternia, Michal; Vejlgaard, Benny

    2014-01-01

    This paper studies the capability of Long-Term Evolution-Advanced (LTE-A) together with WiFi 802.11ac to accommodate the traffic growths of 80x, 500x and 1000x in a high rise building scenario. It provides a guideline on the configuration of the spectrum and the best deployment options for the ev......This paper studies the capability of Long-Term Evolution-Advanced (LTE-A) together with WiFi 802.11ac to accommodate the traffic growths of 80x, 500x and 1000x in a high rise building scenario. It provides a guideline on the configuration of the spectrum and the best deployment options...

  7. Major Successes of Theory-and-Experiment-Combined Studies in Surface Chemistry and Heterogeneous Catalysis.

    Energy Technology Data Exchange (ETDEWEB)

    Somorjai, Gabor A.; Li, Yimin

    2009-11-21

    Experimental discoveries followed by theoretical interpretations that pave the way of further advances by experimentalists is a developing pattern in modern surface chemistry and catalysis. The revolution of modern surface science started with the development of surface-sensitive techniques such as LEED, XPS, AES, ISS and SIMS, in which the close collaboration between experimentalists and theorists led to the quantitative determination of surface structure and composition. The experimental discovery of the chemical activity of surface defects and the trends in the reactivity of transitional metals followed by the explanations from the theoretical studies led to the molecular level understanding of active sites in catalysis. The molecular level knowledge, in turn, provided a guide for experiments to search for new generation of catalysts. These and many other examples of successes in experiment-and-theory-combined studies demonstrate the importance of the collaboration between experimentalists and theorists in the development of modern surface science.

  8. Study of heterogeneous multiplying and non-multiplying media by the neutron pulsed source technique

    International Nuclear Information System (INIS)

    Deniz, V.

    1969-01-01

    The pulsed neutron technique consists essentially in sending in the medium to be studied a short neutron pulse and in determining the asymptotic decay constant of the generated population. The variation of the decay constant as a function of the size of the medium allows the medium characteristics to be defined. This technique has been largely developed these last years and has been applied as well to moderator as to multiplying media, in most cases homogeneous ones. We considered of interest of apply this technique to lattices, to see if useful informations could be collected for lattice calculations. We present here a general theoretical study of the problem, and results and interpretation of a series of experiments made on graphite lattices. There is a good agreement for non-multiplying media. In the case of multiplying media, it is shown that the age value used until now in graphite lattices calculations is over-estimated by about 10 per cent [fr

  9. Family Studies of Sensorimotor and Neurocognitive Heterogeneity in Autism Spectrum Disorders (ASD)

    Science.gov (United States)

    2013-09-01

    Wechsler Intelligence Scale for Children (WISC). 5 b. The protocol now indicates that for eligible participants, we will use information from the...The Differential Ability Scale-Second Edition (DAS) will now be used with children who have difficulty completing the Wechsler tests (WPPSI or WASI...consultants on this award, Drs. Daniel Corcos and David Vaillancourt, each of whom has worked directly with the study team over the past two years to develop

  10. Risk of Unsuccessful Noninvasive Ventilation for Acute Respiratory Failure in Heterogeneous Neuromuscular Diseases: A Retrospective Study

    OpenAIRE

    Kataoka, Hiroshi; Nanaura, Hitoki; Kinugawa, Kaoru; Uchihara, Yuto; Ohara, Hiroya; Eura, Nobuyuki; Syobatake, Ryogo; Sawa, Nobuhiro; Takao, Kiriyama; Sugie, Kazuma; Ueno, Satoshi

    2017-01-01

    If invasive ventilation can be avoided by performing noninvasive mechanical ventilation (NIV) in patients with acute respiratory failure (ARF), the disease can be effectively managed. It is important to clarify the characteristics of patients with neuromuscular diseases in whom initial NIV is likely to be unsuccessful. We studied 27 patients in stable neuromuscular condition who initially received NIV to manage fatal ARF to identify differences in factors immediately before the onset of ARF a...

  11. Interdisciplinary study of reservoir compartments and heterogeneity. Quarterly technical progress report, July 1995--September 1995

    Energy Technology Data Exchange (ETDEWEB)

    Kirk, C.W. Van; Thompson, R.S.

    1995-10-27

    This United States Department of Energy (DOE) research project was established to document the integrated team approach for solving reservoir engineering problems. A field study integrating the disciplines of geology, geophysics, and petroleum engineering will be the mechanism for documenting the integrated approach. This is an area of keen interest to the oil and gas industry. The goal will be to provide tools and approaches that can be used to detect reservoir compartments, reach a better reserve estimate, and improve profits early in the life of a field.

  12. A study on the role of diboride in the heterogeneous nucleation of aluminium

    International Nuclear Information System (INIS)

    Suarez, O. M.

    2004-01-01

    The intangible role of titanium and aluminium diboride in the nucleation of aluminium was re-examined. Two different techniques, complemented with scanning electron microscopy, allowed determining the stability of the diboride in the presence of titanium tri aluminides and liquid aluminium phases. Through rapid scintillated quenching the high temperature diboride were retained and studied. Then, in a diffusion couple, the reactivity of such diboride was tested in contact with pure titanium tri aluminide. It is proposed that a ternary diboride acts as the main catalytic particle in the crystallization of aluminium alloys with refined grains. (Author) 27 refs

  13. Different places, different stories: A study of the spatial heterogeneity of county-level fertility in China

    Directory of Open Access Journals (Sweden)

    Donghui Wang

    2017-08-01

    Full Text Available Background: China has been characterized by persistently low fertility rates since the 1990s. Existing literature has examined the relationship between fertility levels and social, economic, and policy-related determinants. However, the possible spatial variation in these relationships has not been investigated. Objective: The purpose of this study is to examine the potential spatially varying relationships between county-level fertility rates and policy and socioeconomic factors in China. Methods: Using geocoded 2010 county-level census data, this study adopts the geographically weighted regression (GWR method to identify place-specific relationships between county-level total fertility rate (TFR and socioeconomic and policy-related factors. Conclusions: We find that relationships between TFR and widely used social, economic, and policy-related factors (rural Hukou, ethnic minority, female education, net migration rate, poor living standard, sex ratio at birth, fertility policy compliance ratio vary spatially in terms of direction, strength, and magnitude. This spatial variation is largely due to differences in local characteristics. The differences between and the complexities of localities cannot be told by a single story of either government intervention or socioeconomic development. Contribution: This study extends existing fertility research on China by explicitly recognizing the spatial heterogeneity in the impact of policy and socioeconomic factors on the local fertility rate. This study sets the stage for future research that will contextually analyze varying fertility rates at the subnational level in China and other countries.

  14. Kinetics of heterogeneous systems; La cinetique des milieux heterogenes

    Energy Technology Data Exchange (ETDEWEB)

    Deniz, V [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    In this report, a general transport theory treatment is presented for the kinetics study as applied to finite heterogeneous systems. The theory is applicable to experiments near the critical point as well as to pulsed neutron experiments on multiplying or non-multiplying lattices. The general method is also applied to exponential experiments on infinite non-diverging lattices. The particularity of the present study is the explicit introduction of heterogeneity in the formulation and the search for the dependence of the parameters on the buckling of the finite medium. As a result of this, the finite medium parameters are in the first place expressed in terms of the corresponding infinite medium ones through the buckling and the anisotropic migration areas, and in the second place all the parameters are expressed as integrals only over an unit cell instead of over the whole pile. A preliminary less detailed study is first made in order to distinguish clearly between what are called 'dynamic parameters' and 'static parameters', and to define the meanings given in this report to these two terms. In the appendices are given approximate one-group treatments for the study of the dynamic fine structure, the time constant in infinite lattices, and the anisotropic diffusion coefficients in non-multiplying lattices. (author) [French] On presente dans ce rapport une methode generale, utilisant la theorie du transport pour l'etude de la cinetique des milieux finis heterogenes. La theorie est applicable aussi bien aux experiences pres de la criticite qu'aux experiences par sources pulsees de neutrons sur des reseaux multiplicateurs ou non-multiplicateurs. La methode generale est aussi appliquee aux experiences exponentielles sur des reseaux infinis non-divergents. La particularite de l'etude est l'introduction explicite de l'heterogeneite dans la formulation et la recherche de la dependance des parametres par rapport au laplacien du reseau fini. Il en resulte d'une part que les

  15. A study of the evaporation of heterogeneous water droplets under active heating

    Science.gov (United States)

    Piskunov, Maxim; Legros, Jean Claude; Strizhak, Pavel

    2016-11-01

    Using high-speed video registration tools with a sample rate of 102-104 frames per second (fps), we studied the patterns in the evaporation of water droplets containing 1 and 2 mm individual metallic inclusions in a high-temperature gas environment. The materials of choice for the inclusions were steels (AISI 1080 carbon steel and AISI type 316L stainless steel) and pure nickel. We established the lifetimes τh of the liquid droplets under study with a controlled increase in the gas environment temperature up to 900 K. We also considered the physical aspects behind the τh distribution in the experiments conducted and specified the conditions for more effective cooling of metallic inclusions. Following the experimental research findings, a method was devised for effective reactor vessel cooling to avoid a meltdown at a nuclear power plant. The optimization of heat and mass transfer modes was performed within the framework of the strategic plan for the development of National Research Tomsk Polytechnic University as one of the world-leading universities.

  16. A case study of heterogeneous fleet vehicle routing problem: Touristic distribution application in Alanya

    Directory of Open Access Journals (Sweden)

    Kenan Karagül

    2014-07-01

    Full Text Available In this study, Fleet Size and Mix Vehicle Routing Problem is considered in order to optimize the distribution of the tourists who have traveled between the airport and the hotels in the shortest distance by using the minimum cost. The initial solution space for the related methods are formed as a combination of Savings algorithm, Sweep algorithm and random permutation alignment. Then, two well-known solution methods named as Standard Genetic Algorithms and random search algorithms are used for changing the initial solutions. Computational power of the machine and heuristic algorithms are used instead of human experience and human intuition in order to solve the distribution problem of tourists coming to hotels in Alanya region from Antalya airport. For this case study, daily data of tourist distributions performed by an agency operating in Alanya region are considered. These distributions are then modeled as Vehicle Routing Problem to calculate the solutions for various applications. From the comparisons with the decision of a human expert, it is seen that the proposed methods produce better solutions with respect to human experience and insight. Random search method produces a solution more favorable in terms of time. As a conclusion, it is seen that, owing to the distribution plans offered by the obtained solutions, the agencies may reduce the costs by achieving savings up to 35%.

  17. Thermovoltage in scanning tunnelling microscopy. Study of heterogeneous metal surfaces on atomic scale; Thermospannung in der Rastertunnelmikroskopie. Untersuchung heterogener Metalloberflaechen auf atomarer Skala

    Energy Technology Data Exchange (ETDEWEB)

    Weyers, B.

    2005-07-01

    In this thesis the thermovoltage has been studied via a tunnel barrier under different aspects. Au(111) has been chosen as substrate. The mean free path of the electrons on the Au(111) surface was determined by a comparison of the standing waves on stage edges with the theoretical prediction. The measurements were performed at different temperatures. Detailed studies were performed on Au(111), Cu(111), and Cu(110) in order to examine the question whether the cause for strong signal on the stage edges lies in the surface state itself or in the band gap. The mani theme of this thesis is the study of a binary metal system, in this case silver on Au(111).

  18. Interdisciplinary study of reservoir compartments and heterogeneity. Final report, October 1, 1993--December 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Van Kirk, C.

    1998-01-01

    A case study approach using Terry Sandstone production from the Hambert-Aristocrat Field, Weld County, Colorado was used to document the process of integration. One specific project goal is to demonstrate how a multidisciplinary approach can be used to detect reservoir compartmentalization and improve reserve estimates. The final project goal is to derive a general strategy for integration for independent operators. Teamwork is the norm for the petroleum industry where teams of geologists, geophysicists, and petroleum engineers work together to improve profits through a better understanding of reservoir size, compartmentalization, and orientation as well as reservoir flow characteristics. In this manner, integration of data narrows the uncertainty in reserve estimates and enhances reservoir management decisions. The process of integration has proven to be iterative. Integration has helped identify reservoir compartmentalization and reduce the uncertainty in the reserve estimates. This research report documents specific examples of integration and the economic benefits of integration.

  19. Study on electric parameters of wild and cultivated cotton forms being in normal state and irradiated

    International Nuclear Information System (INIS)

    Nazirov, N.N.; Kamalov, N.; Norbaev, N.

    1978-01-01

    The radiation effect on electric conductivity of tissues in case of alternating current, electrical capacity and cell impedance has been studied. Gamma irradiation of seedlings results in definite changes of electric factors of cells (electric conductivity, electric capacity, impedance). It is shown that especially strong changes have been revealed during gamma irradiation of radiosensitive wild form of cotton plants. The deviation of cell electric factors from the standard depends on the violation of evolutionally composed ion heterogeneity and cell colloid system state, which results in changes in their structure and metabolism in them

  20. Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study: Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography

    Directory of Open Access Journals (Sweden)

    Hua-Guang Zheng

    2015-01-01

    Conclusions: mRT is heterogeneous in presynaptic nigrostriatal dopaminergic degeneration, which can be determined by DAT-PET brain imaging. Clinical and electrophysiological features may provide clues to distinguish PD from SWEDDs.

  1. Information Mining from Heterogeneous Data Sources: A Case Study on Drought Predictions

    Directory of Open Access Journals (Sweden)

    Getachew B. Demisse

    2017-07-01

    Full Text Available The objective of this study was to develop information mining methodology for drought modeling and predictions using historical records of climate, satellite, environmental, and oceanic data. The classification and regression tree (CART approach was used for extracting drought episodes at different time-lag prediction intervals. Using the CART approach, a number of successful model trees were constructed, which can easily be interpreted and used by decision makers in their drought management decisions. The regression rules produced by CART were found to have correlation coefficients from 0.71–0.95 in rules-alone modeling. The accuracies of the models were found to be higher in the instance and rules model (0.77–0.96 compared to the rules-alone model. From the experimental analysis, it was concluded that different combinations of the nearest neighbor and committee models significantly increase the performances of CART drought models. For more robust results from the developed methodology, it is recommended that future research focus on selecting relevant attributes for slow-onset drought episode identification and prediction.

  2. Risk of Unsuccessful Noninvasive Ventilation for Acute Respiratory Failure in Heterogeneous Neuromuscular Diseases: A Retrospective Study.

    Science.gov (United States)

    Kataoka, Hiroshi; Nanaura, Hitoki; Kinugawa, Kaoru; Uchihara, Yuto; Ohara, Hiroya; Eura, Nobuyuki; Syobatake, Ryogo; Sawa, Nobuhiro; Takao, Kiriyama; Sugie, Kazuma; Ueno, Satoshi

    2017-02-20

    If invasive ventilation can be avoided by performing noninvasive mechanical ventilation (NIV) in patients with acute respiratory failure (ARF), the disease can be effectively managed. It is important to clarify the characteristics of patients with neuromuscular diseases in whom initial NIV is likely to be unsuccessful. We studied 27 patients in stable neuromuscular condition who initially received NIV to manage fatal ARF to identify differences in factors immediately before the onset of ARF among patients who receive continuous NIV support, patients who are switched from NIV to invasive ventilation, and patients in whom NIV is discontinued. Endpoints were evaluated 24 and 72 hours after the initiation of NIV. After 24 hours, all but 1 patient with amyotrophic lateral sclerosis (ALS) received continuous NIV support. 72 hours later, 5 patients were switched from NIV to invasive ventilation, and 5 patients continued to receive NIV support. 72 hours after the initiation of NIV, the proportion of patients with a diagnosis of ALS differed significantly among the three groups (P=0.039). NIV may be attempted to manage acute fatal respiratory failure associated with neuromuscular diseases, but clinicians should carefully manage the clinical course in patients with ALS.

  3. Risk of unsuccessful noninvasive ventilation for acute respiratory failure in heterogeneous neuromuscular diseases: a retrospective study

    Directory of Open Access Journals (Sweden)

    Hiroshi Kataoka

    2017-03-01

    Full Text Available If invasive ventilation can be avoided by performing noninvasive mechanical ventilation (NIV in patients with acute respiratory failure (ARF, the disease can be effectively managed. It is important to clarify the characteristics of patients with neuromuscular diseases in whom initial NIV is likely to be unsuccessful. We studied 27 patients in stable neuromuscular condition who initially received NIV to manage fatal ARF to identify differences in factors immediately before the onset of ARF among patients who receive continuous NIV support, patients who are switched from NIV to invasive ventilation, and patients in whom NIV is discontinued. Endpoints were evaluated 24 and 72 hours after the initiation of NIV. After 24 hours, all but 1 patient with amyotrophic lateral sclerosis (ALS received continuous NIV support. 72 hours later, 5 patients were switched from NIV to invasive ventilation, and 5 patients continued to receive NIV support. 72 hours after the initiation of NIV, the proportion of patients with a diagnosis of ALS differed significantly among the three groups (P=0.039. NIV may be attempted to manage acute fatal respiratory failure associated with neuromuscular diseases, but clinicians should carefully manage the clinical course in patients with ALS.

  4. Language growth in children with heterogeneous language disorders: a population study.

    Science.gov (United States)

    Norbury, Courtenay Frazier; Vamvakas, George; Gooch, Debbie; Baird, Gillian; Charman, Tony; Simonoff, Emily; Pickles, Andrew

    2017-10-01

    Language development has been characterised by significant individual stability from school entry. However, the extent to which trajectories of language growth vary in children with language disorder as a function of co-occurring developmental challenges is a question of theoretical import, with implications for service provision. SCALES employed a population-based survey design with sample weighting procedures to estimate growth in core language skills over the first three years of school. A stratified sample (n = 529) received comprehensive assessment of language, nonverbal IQ, and social, emotional and behavioural difficulties at 5-6 years of age and 95% of the sample (n = 499) were assessed again at ages 7-8. Language growth was measured using both raw and standard scores in children with typical development, children with language disorder of unknown origin, and children with language disorders associated with a known clinical condition and/or intellectual disability. Overall, language was stable at the individual level (estimated ICC = 0.95) over the first three years of school. Linear mixed effects models highlighted steady growth in language raw scores across all three groups, including those with multiple developmental challenges. There was little evidence, however, that children with language disorders were narrowing the gap with peers (z-scores). Adjusted models indicated that while nonverbal ability, socioeconomic status and social, emotional and behavioural deficits predicted initial language score (intercept), none predicted language growth (slope). These findings corroborate previous studies suggesting stable language trajectories after ages 5-6 years, but add considerably to previous work by demonstrating similar developmental patterns in children with additional nonverbal cognitive deficits, social, emotional, and behavioural challenges, social disadvantage or clinical diagnoses. © 2017 The Authors. Journal of Child Psychology and

  5. Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity

    Directory of Open Access Journals (Sweden)

    He N. Xu

    2014-03-01

    Full Text Available NAD+/NADH redox state has been implicated in many diseases such as cancer and diabetes as well as in the regulation of embryonic development and aging. To fluorimetrically assess the mitochondrial redox state, Dr. Chance and co-workers measured the fluorescence of NADH and oxidized flavoproteins (Fp including flavin–adenine–dinucleotide (FAD and demonstrated their ratio (i.e. the redox ratio is a sensitive indicator of the mitochondrial redox states. The Chance redox scanner was built to simultaneously measure NADH and Fp in tissue at submillimeter scale in 3D using the freeze-trap protocol. This paper summarizes our recent research experience, development and new applications of the redox scanning technique in collaboration with Dr. Chance beginning in 2005. Dr. Chance initiated or actively involved in many of the projects during the last several years of his life. We advanced the redox scanning technique by measuring the nominal concentrations (in reference to the frozen solution standards of the endogenous fluorescent analytes, i.e., [NADH] and [Fp] to quantify the redox ratios in various biological tissues. The advancement has enabled us to identify an array of the redox indices as quantitative imaging biomarkers (including [NADH], [Fp], [Fp]/([NADH]+[Fp], [NADH]/[Fp], and their standard deviations for studying some important biological questions on cancer and normal tissue metabolism. We found that the redox indices were associated or changed with (1 tumorigenesis (cancer versus non-cancer of human breast tissue biopsies; (2 tumor metastatic potential; (3 tumor glucose uptake; (4 tumor p53 status; (5 PI3K pathway activation in pre-malignant tissue; (6 therapeutic effects on tumors; (7 embryonic stem cell differentiation; (8 the heart under fasting. Together, our work demonstrated that the tissue redox indices obtained from the redox scanning technique may provide useful information about tissue metabolism and physiology status in normal

  6. Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study.

    Science.gov (United States)

    Andersen, Vibeke; Ernst, Anja; Sventoraityte, Jurgita; Kupcinskas, Limas; Jacobsen, Bent A; Krarup, Henrik B; Vogel, Ulla; Jonaitis, Laimas; Denapiene, Goda; Kiudelis, Gediminas; Balschun, Tobias; Franke, Andre

    2011-10-13

    Differences in the genetic architecture of inflammatory bowel disease between different European countries and ethnicities have previously been reported. In the present study, we wanted to assess the role of 11 newly identified UC risk variants, derived from a recent European UC genome wide association study (GWAS) (Franke et al., 2010), for 1) association with UC in the Nordic countries, 2) for population heterogeneity between the Nordic countries and the rest of Europe, and, 3) eventually, to drive some of the previous findings towards overall genome-wide significance. Eleven SNPs were replicated in a Danish sample consisting of 560 UC patients and 796 controls and nine missing SNPs of the German GWAS study were successfully genotyped in the Baltic sample comprising 441 UC cases and 1156 controls. The independent replication data was then jointly analysed with the original data and systematic comparisons of the findings between ethnicities were made. Pearson's χ2, Breslow-Day (BD) and Cochran-Mantel-Haenszel (CMH) tests were used for association analyses and heterogeneity testing. The rs5771069 (IL17REL) SNP was not associated with UC in the Danish panel. The rs5771069 (IL17REL) SNP was significantly associated with UC in the combined Baltic, Danish and Norwegian UC study sample driven by the Norwegian panel (OR = 0.89, 95% CI: 0.79-0.98, P = 0.02). No association was found between rs7809799 (SMURF1/KPNA7) and UC (OR = 1.20, 95% CI: 0.95-1.52, P = 0.10) or between UC and all other remaining SNPs. We had 94% chance of detecting an association for rs7809799 (SMURF1/KPNA7) in the combined replication sample, whereas the power were 55% or lower for the remaining SNPs.Statistically significant PBD was found for OR heterogeneity between the combined Baltic, Danish, and Norwegian panel versus the combined German, British, Belgian, and Greek panel (rs7520292 (P = 0.001), rs12518307 (P = 0.007), and rs2395609 (TCP11) (P = 0.01), respectively).No SNP reached genome

  7. Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study

    Directory of Open Access Journals (Sweden)

    Jonaitis Laimas

    2011-10-01

    Full Text Available Abstract Background Differences in the genetic architecture of inflammatory bowel disease between different European countries and ethnicities have previously been reported. In the present study, we wanted to assess the role of 11 newly identified UC risk variants, derived from a recent European UC genome wide association study (GWAS (Franke et al., 2010, for 1 association with UC in the Nordic countries, 2 for population heterogeneity between the Nordic countries and the rest of Europe, and, 3 eventually, to drive some of the previous findings towards overall genome-wide significance. Methods Eleven SNPs were replicated in a Danish sample consisting of 560 UC patients and 796 controls and nine missing SNPs of the German GWAS study were successfully genotyped in the Baltic sample comprising 441 UC cases and 1156 controls. The independent replication data was then jointly analysed with the original data and systematic comparisons of the findings between ethnicities were made. Pearson's χ2, Breslow-Day (BD and Cochran-Mantel-Haenszel (CMH tests were used for association analyses and heterogeneity testing. Results The rs5771069 (IL17REL SNP was not associated with UC in the Danish panel. The rs5771069 (IL17REL SNP was significantly associated with UC in the combined Baltic, Danish and Norwegian UC study sample driven by the Norwegian panel (OR = 0.89, 95% CI: 0.79-0.98, P = 0.02. No association was found between rs7809799 (SMURF1/KPNA7 and UC (OR = 1.20, 95% CI: 0.95-1.52, P = 0.10 or between UC and all other remaining SNPs. We had 94% chance of detecting an association for rs7809799 (SMURF1/KPNA7 in the combined replication sample, whereas the power were 55% or lower for the remaining SNPs. Statistically significant PBD was found for OR heterogeneity between the combined Baltic, Danish, and Norwegian panel versus the combined German, British, Belgian, and Greek panel (rs7520292 (P = 0.001, rs12518307 (P = 0.007, and rs2395609 (TCP11 (P = 0

  8. Study of the decay asymmetry parameter and CP violation parameter in the Λc+→Λπ decay

    Science.gov (United States)

    FOCUS Collaboration; Link, J. M.; Yager, P. M.; Anjos, J. C.; Bediaga, I.; Castromonte, C.; Machado, A. A.; Magnin, J.; Massafferri, A.; de Miranda, J. M.; Pepe, I. M.; Polycarpo, E.; Dos Reis, A. C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sánchez-Hernández, A.; Uribe, C.; Vázquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J. P.; O'Reilly, B.; Segoni, I.; Stenson, K.; Butler, J. N.; Cheung, H. W. K.; Chiodini, G.; Gaines, I.; Garbincius, P. H.; Garren, L. A.; Gottschalk, E.; Kasper, P. H.; Kreymer, A. E.; Kutschke, R.; Wang, M.; Benussi, L.; Bertani, M.; Bianco, S.; Fabbri, F. L.; Pacetti, S.; Zallo, A.; Reyes, M.; Cawlfield, C.; Kim, D. Y.; Rahimi, A.; Wiss, J.; Gardner, R.; Kryemadhi, A.; Chung, Y. S.; Kang, J. S.; Ko, B. R.; Kwak, J. W.; Lee, K. B.; Cho, K.; Park, H.; Alimonti, G.; Barberis, S.; Boschini, M.; Cerutti, A.; D'Angelo, P.; Dicorato, M.; Dini, P.; Edera, L.; Erba, S.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport, T. F.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Lopes Pegna, D.; Merlo, M. M.; Pantea, D.; Ratti, S. P.; Riccardi, C.; Vitulo, P.; Göbel, C.; Olatora, J.; Hernandez, H.; Lopez, A. M.; Mendez, H.; Paris, A.; Quinones, J.; Ramirez, J. E.; Zhang, Y.; Wilson, J. R.; Handler, T.; Mitchell, R.; Engh, D.; Hosack, M.; Johns, W. E.; Luiggi, E.; Moore, J. E.; Nehring, M.; Sheldon, P. D.; Vaandering, E. W.; Webster, M.; Sheaff, M.

    2006-03-01

    Using data from the FOCUS (E831) experiment at Fermilab, we present a new measurement of the weak decay-asymmetry parameter αΛ_c in Λc+→Λπ decay. Comparing particle with antiparticle decays, we obtain the first measurement of the CP violation parameter A≡αΛ_c+ααΛ_c-α. We obtain αΛ_c=-0.78±0.16±0.19 and A=-0.07±0.19±0.24 where errors are statistical and systematic.

  9. Feasibility Study of Neutron Multiplicity Assay for a Heterogeneous Sludge Sample containing Na, Pu and other Impurities

    International Nuclear Information System (INIS)

    Nakamura, H.; Nakamichi, H.; Mukai, Y.; Yoshimoto, K.; Beddingfield, D.H.

    2010-01-01

    To reduce radioactivity of liquid waste generated at PCDF, a neutralization precipitation processes of radioactive nuclides by sodium hydroxide is used. We call the precipitate a 'sludge' after calcination. Pu mass in the sludge is normally determined by sampling and DA within the required uncertainty on DIQ. Annual yield of the mass is small but it accumulates and reaches to a few kilograms, so it is declared as retained waste and verified at PIV. A HM-5-based verification is applied for sludge verification. The sludge contains many chemical components. For example, Pu (-10wt%), U, Am, SUS components, halogens, NaNO 3 (main component), residual NaOH, and moisture. They are mixed together as an impure heterogeneous sludge sample. As a result, there is a large uncertainty in the sampling and DA that is currently used at PCDF. In order to improve the material accounting, we performed a feasibility study using neutron multiplicity assay for impure sludge samples. We have measured selected sludge samples using a multiplicity counter which is called FCAS (Fast Carton Assay System) which was designed by JAEA and Canberra. The PCDF sludge materials fall into the category of 'difficult to measure' because of the high levels of impurities, high alpha values and somewhat small Pu mass. For the sludge measurements, it was confirmed that good consistency between Pu mass in a pure sludge standard (PuO 2 -Na 2 U 2 O 7 , alpha=7) and the DA could be obtained. For unknown samples, using 14-hour measurements, we could obtain quite low statistical uncertainty on Doubles (-1%) and Triples (-10%) count rate although the alpha value was extremely high (15-25) and FCAS efficiency was relatively low (40%) for typical multiplicity counters. Despite the detector efficiency challenges and the material challenges (high alpha, low Pu mass, heterogeneous matrix), we have been able to obtain assay results that greatly exceed the accountancy requirements for retained waste materials. We have

  10. Modeling the X-ray Process, and X-ray Flaw Size Parameter for POD Studies

    Science.gov (United States)

    Koshti, Ajay M.

    2014-01-01

    Nondestructive evaluation (NDE) method reliability can be determined by a statistical flaw detection study called probability of detection (POD) study. In many instances, the NDE flaw detectability is given as a flaw size such as crack length. The flaw is either a crack or behaving like a crack in terms of affecting the structural integrity of the material. An alternate approach is to use a more complex flaw size parameter. The X-ray flaw size parameter, given here, takes into account many setup and geometric factors. The flaw size parameter relates to X-ray image contrast and is intended to have a monotonic correlation with the POD. Some factors such as set-up parameters, including X-ray energy, exposure, detector sensitivity, and material type that are not accounted for in the flaw size parameter may be accounted for in the technique calibration and controlled to meet certain quality requirements. The proposed flaw size parameter and the computer application described here give an alternate approach to conduct the POD studies. Results of the POD study can be applied to reliably detect small flaws through better assessment of effect of interaction between various geometric parameters on the flaw detectability. Moreover, a contrast simulation algorithm for a simple part-source-detector geometry using calibration data is also provided for the POD estimation.

  11. APPLICATION OPENFOAM TO STUDY THE EFFECT OF GEOMETRICAL PARAMETERS ON THE AERODYNAMIC CHARACTERISTICS OF BLUFF BODIES

    Directory of Open Access Journals (Sweden)

    V. V. Efimov

    2014-01-01

    Full Text Available Justification of possibility of application of an OpenFOAM package for obtaining aerodynamic characteristics of bluff bodies and studying of their dependence on geometrical parameters.

  12. Synchronization in networks with heterogeneous coupling delays

    Science.gov (United States)

    Otto, Andreas; Radons, Günter; Bachrathy, Dániel; Orosz, Gábor

    2018-01-01

    Synchronization in networks of identical oscillators with heterogeneous coupling delays is studied. A decomposition of the network dynamics is obtained by block diagonalizing a newly introduced adjacency lag operator which contains the topology of the network as well as the corresponding coupling delays. This generalizes the master stability function approach, which was developed for homogenous delays. As a result the network dynamics can be analyzed by delay differential equations with distributed delay, where different delay distributions emerge for different network modes. Frequency domain methods are used for the stability analysis of synchronized equilibria and synchronized periodic orbits. As an example, the synchronization behavior in a system of delay-coupled Hodgkin-Huxley neurons is investigated. It is shown that the parameter regions where synchronized periodic spiking is unstable expand when increasing the delay heterogeneity.

  13. Study of intramolecular isotope heterogeneity of organic oxy acids in order to detect sophisticated wines and juice drinks

    Directory of Open Access Journals (Sweden)

    Kuzmina Helen

    2014-01-01

    Full Text Available According to International Code of Oenological Practices it is allowed to use acide L(+tartrique for wine acidification, while use of synthetic dihydroxysuccinic acid is forbidden. Today it is impossible to differentiate natural dihydroxysuccinic acid from synthetic one by standard techniques. Even by using very sensitive method of isotope mass spectrometry certain difficulties emerge because total isotope characteristics of carbon of dihydroxysuccinic acid of different nature have the same values. However, isotope characteristics of carbon of intramolecular structural groups of dihydroxysuccinic acid made of different raw materials differ significantly. This allows specifying the nature of dihydroxysuccinic acid that is used for making of wines and juice drinks. In Russia, scientific and research institute of beer brewing and wine-making industry carried out a work for studying isotope characteristics of intramolecular isotope heterogeneity of dihydroxysuccinic acid from different origins in order to identify wines and juice drinks. Isotope characteristics of organic oxy acids from different origins were studied including them obtained by synthetic way and numeric range of value δ13 C,‰ were specified. The obtained results allow performing identification tests of wines and juice drinks to find out the products that contain not specified additives as that allowed for its use in production process.

  14. Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study: Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography.

    Science.gov (United States)

    Zheng, Hua-Guang; Zhang, Rong; Li, Xin; Li, Fang-Fei; Wang, Ya-Chen; Wang, Xue-Mei; Lu, Ling-Long; Feng, Tao

    2015-07-05

    The relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD) remains controversial. In this study, we aimed to assess the function of presynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography (DAT-PET) and to evaluate the utility of clinical features or electrophysiological studies in differential diagnosis. Thirty-three consecutive patients with mRT were enrolled prospectively. The Unified Parkinson's Disease Rating Scale and electromyography were tested before DAT-PET. Striatal asymmetry index (SAI) was calculated, and a normal DAT-PET was defined as a SAI of hygiene score, walking in motor experiences of daily living (Part II) and motor examination (Part III) were significant different between two groups (P postural tremor tend to be higher in the SWEDDs group (P = 0.08 and P = 0.05, respectively). mRT is heterogeneous in presynaptic nigrostriatal dopaminergic degeneration, which can be determined by DAT-PET brain imaging. Clinical and electrophysiological features may provide clues to distinguish PD from SWEDDs.

  15. Salivary caries parameters: Comparative study among Yemeni khat chewers and nonchewers

    OpenAIRE

    Khaled Rashad Al-Alimi; Abdul Aziz Abdul Razak; Roslan Saub

    2014-01-01

    Background/purpose: Millions of people in Yemen and East African countries chew khat for more than 5 hours daily for its amphetamine-like effects. Previous studies have associated khat chewing with salivary glands enlargement, inflammation, and xerostomia. However, no information is available on the possible effects of this habit on salivary parameters. This comparative study aims to evaluate salivary parameters, such as salivary flow rate, pH, and viscosity among Yemeni khat chewers and nonc...

  16. Knudsen cell and smog chamber study of the heterogeneous uptake of sulfur dioxide on Chinese mineral dust.

    Science.gov (United States)

    Zhou, Li; Wang, Weigang; Gai, Yanbo; Ge, Maofa

    2014-12-01

    The heterogeneous uptake processes of sulfur dioxide on two types of Chinese mineral dust (Inner Mongolia desert dust and Xinjiang sierozem) were investigated using both Knudsen cell and smog chamber system. The temperature dependence of the uptake coefficients was studied over a range from 253 to 313 K using the Knudsen cell reactor, the initial uptake coefficients decreased with the increasing of temperature for these two mineral dust samples, whereas the steady state uptake coefficients of the Xinjiang sierozem increased with the temperature increasing, and these temperature dependence functions were obtained for the first time. In the smog chamber experiments at room temperature, the steady state uptake coefficients of SO2 decreased evidently with the increasing of sulfur dioxide initial concentration from 1.72 × 10¹² to 6.15 × 10¹² mol/cm³. Humid air had effect on the steady state uptake coefficients of SO₂onto Inner Mongolia desert dust. Consequences about the understanding of the uptake processes onto mineral dust samples and the environmental implication were also discussed. Copyright © 2014. Published by Elsevier B.V.

  17. Numerical study of compositional compressible degenerate two-phase flow in saturated–unsaturated heterogeneous porous media

    KAUST Repository

    Saad, Ali S.; Saad, Bilal Mohammed; Saad, Mazen

    2016-01-01

    We study the convergence of a combined finite volume-nonconforming finite element scheme on general meshes for a partially miscible two-phase flow model in anisotropic porous media. This model includes capillary effects and exchange between the phases. The diffusion term, which can be anisotropic and heterogeneous, is discretized by piecewise linear nonconforming triangular finite elements. The other terms are discretized by means of a cell-centered finite volume scheme on a dual mesh. The relative permeability of each phase is decentered according to the sign of the velocity at the dual interface. The convergence of the scheme is proved thanks to an estimate on the two pressures which allows to show estimates on the discrete time and compactness results in the case of degenerate relative permeabilities. A key point in the scheme is to use particular averaging formula for the dissolution function arising in the diffusion term. We show also a simulation of hydrogen production in nuclear waste management. Numerical results are obtained by in-house numerical code. © 2015 Elsevier Ltd.

  18. Numerical study of compositional compressible degenerate two-phase flow in saturated–unsaturated heterogeneous porous media

    KAUST Repository

    Saad, Ali S.

    2016-01-02

    We study the convergence of a combined finite volume-nonconforming finite element scheme on general meshes for a partially miscible two-phase flow model in anisotropic porous media. This model includes capillary effects and exchange between the phases. The diffusion term, which can be anisotropic and heterogeneous, is discretized by piecewise linear nonconforming triangular finite elements. The other terms are discretized by means of a cell-centered finite volume scheme on a dual mesh. The relative permeability of each phase is decentered according to the sign of the velocity at the dual interface. The convergence of the scheme is proved thanks to an estimate on the two pressures which allows to show estimates on the discrete time and compactness results in the case of degenerate relative permeabilities. A key point in the scheme is to use particular averaging formula for the dissolution function arising in the diffusion term. We show also a simulation of hydrogen production in nuclear waste management. Numerical results are obtained by in-house numerical code. © 2015 Elsevier Ltd.

  19. A monopoly pricing model for diffusion maximization based on heterogeneous nodes and negative network externalities (Case study: A novel product

    Directory of Open Access Journals (Sweden)

    Aghdas Badiee

    2018-10-01

    Full Text Available Social networks can provide sellers across the world with invaluable information about the structure of possible influences among different members of a network, whether positive or negative, and can be used to maximize diffusion in the network. Here, a novel mathematical monopoly product pricing model is introduced for maximization of market share in noncompetitive environment. In the proposed model, a customer’s decision to buy a product is not only based on the price, quality and need time for the product but also on the positive and negative influences of his/her neighbors. Therefore, customers are considered heterogeneous and a referral bonus is granted to every customer whose neighbors also buy the product. Here, the degree of influence is directly related to the intensity of the customers’ relationships. Finally, using the proposed model for a real case study, the optimal policy for product sales that is the ratio of product sale price in comparison with its cost and also the optimal amounts of referral bonus per customer is achieved.

  20. Oyster Creek cycle 10 nodal model parameter optimization study using PSMS

    International Nuclear Information System (INIS)

    Dougher, J.D.

    1987-01-01

    The power shape monitoring system (PSMS) is an on-line core monitoring system that uses a three-dimensional nodal code (NODE-B) to perform nodal power calculations and compute thermal margins. The PSMS contains a parameter optimization function that improves the ability of NODE-B to accurately monitor core power distributions. This functions iterates on the model normalization parameters (albedos and mixing factors) to obtain the best agreement between predicted and measured traversing in-core probe (TIP) reading on a statepoint-by-statepoint basis. Following several statepoint optimization runs, an average set of optimized normalization parameters can be determined and can be implemented into the current or subsequent cycle core model for on-line core monitoring. A statistical analysis of 19 high-power steady-state state-points throughout Oyster Creek cycle 10 operation has shown a consistently poor virgin model performance. The normalization parameters used in the cycle 10 NODE-B model were based on a cycle 8 study, which evaluated only Exxon fuel types. The introduction of General Electric (GE) fuel into cycle 10 (172 assemblies) was a significant fuel/core design change that could have altered the optimum set of normalization parameters. Based on the need to evaluate a potential change in the model normalization parameters for cycle 11 and in an attempt to account for the poor cycle 10 model performance, a parameter optimization study was performed

  1. Percolation in Heterogeneous Media

    International Nuclear Information System (INIS)

    Vocka, Radim

    1999-01-01

    This work is a theoretical reflection on the problematic of the modeling of heterogeneous media, that is on the way of their simple representation conserving their characteristic features. Two particular problems are addressed in this thesis. Firstly, we study the transport in porous media, that is in a heterogeneous media which structure is quenched. A pore space is represented in a simple way - a pore is symbolized as a tube of a given length and a given diameter. The fact that the correlations in the distribution of pore sizes are taken into account by a construction of a hierarchical network makes possible the modeling of porous media with a porosity distributed over several length scales. The transport in the hierarchical network shows qualitatively different phenomena from those observed in simpler models. A comparison of numerical results with experimental data shows that the hierarchical network gives a good qualitative representation of the structure of real porous media. Secondly, we study a problem of the transport in a heterogeneous media which structure is evolving during the time. The models where the evolution of the structure is not influenced by the transport are studied in detail. These models present a phase transition of the same nature as that observed on the percolation networks. We propose a new theoretical description of this transition, and we express critical exponents describing the evolution of the conductivity as a function of fundamental exponents of percolation theory. (author) [fr

  2. [Study of the plantar arch: correlations between podometrical and radiological parameters. results of a prospective study of 79 cases].

    Science.gov (United States)

    Maes, R; Dojcinovic, S; Andrianne, Y; Burny, F

    2006-01-01

    The authors present a prospective study on the potential correlations between eight footprint parameters and three radiological parameters in the study of the plantar arch. Seventy nine patients were evaluated in 2001. The eight footprint parameters were as fellows : the arch angle, the Chippaux-Smirak's index, the Quamra's contact index 2,3 and 4, the Schwartz's footprint angle, the Staheli's arch index and the arch length index. The three radiological parameters were as fellows : the Djian-Annonier's angle, the Méary's angle and the calcaneal inclination. This prospective study confirms the best correlation, found in others studies, obtained between the Djian-Annonier's angle and the Chippaux-Smirak. The use of the Méary's angle and the calcaneal inclination is not justified because they have bad correlations with footprint parameters.

  3. Study of the decay asymmetry parameter and CP violation parameter in the Lambda(c)+ ---> Lambda pi+ decay

    Energy Technology Data Exchange (ETDEWEB)

    Link, J.M.; Yager, P.M.; /UC, Davis; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferri, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; /Rio de Janeiro, CBPF; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; /CINVESTAV, IPN; Agostino, L.; Cinquini, L.; Cumalat,; /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN,

    2005-09-01

    Using data from the FOCUS (E831) experiment at Fermilab, we present a new measurement of the weak decay-asymmetry parameter a{sub {Lambda}{sub c}} in {Lambda}{sub c}{sup +} {yields} {Lambda}{pi}{sup +} decay. Comparing particle with antiparticle decays, we obtain the first measurement of the CP violation parameter {Alpha} {triple_bond} a{sub {Lambda}{sub c}} + a{sub {ovr {Lambda}{sub c}}}/a{sub {Lambda}{sub c}} - a{sub {ovr {Lambda}{sub c}}}. We obtain a{sub {Lambda}{sub c}} = -0.78 {+-} 0.16 {+-} 0.13 and {Alpha} = -0.07 {+-} 0.19 {+-} 0.12 where errors are statistical and systematic.

  4. Optimal Control of Heterogeneous Systems with Endogenous Domain of Heterogeneity

    International Nuclear Information System (INIS)

    Belyakov, Anton O.; Tsachev, Tsvetomir; Veliov, Vladimir M.

    2011-01-01

    The paper deals with optimal control of heterogeneous systems, that is, families of controlled ODEs parameterized by a parameter running over a domain called domain of heterogeneity. The main novelty in the paper is that the domain of heterogeneity is endogenous: it may depend on the control and on the state of the system. This extension is crucial for several economic applications and turns out to rise interesting mathematical problems. A necessary optimality condition is derived, where one of the adjoint variables satisfies a differential inclusion (instead of equation) and the maximization of the Hamiltonian takes the form of “min-max”. As a consequence, a Pontryagin-type maximum principle is obtained under certain regularity conditions for the optimal control. A formula for the derivative of the objective function with respect to the control from L ∞ is presented together with a sufficient condition for its existence. A stylized economic example is investigated analytically and numerically.

  5. Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIV

    Energy Technology Data Exchange (ETDEWEB)

    Endres, Christopher J; Pomper, Martin G [Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231 (United States); Hammoud, Dima A, E-mail: endres@jhmi.edu [Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD (United States)

    2011-04-21

    When applicable, it is generally preferred to evaluate positron emission tomography (PET) studies using a reference tissue-based approach as that avoids the need for invasive arterial blood sampling. However, most reference tissue methods have been shown to have a bias that is dependent on the level of tracer binding, and the variability of parameter estimates may be substantially affected by noise level. In a study of serotonin transporter (SERT) binding in HIV dementia, it was determined that applying parameter coupling to the simplified reference tissue model (SRTM) reduced the variability of parameter estimates and yielded the strongest between-group significant differences in SERT binding. The use of parameter coupling makes the application of SRTM more consistent with conventional blood input models and reduces the total number of fitted parameters, thus should yield more robust parameter estimates. Here, we provide a detailed evaluation of the application of parameter constraint and parameter coupling to [{sup 11}C]DASB PET studies. Five quantitative methods, including three methods that constrain the reference tissue clearance (k{sup r}{sub 2}) to a common value across regions were applied to the clinical and simulated data to compare measurement of the tracer binding potential (BP{sub ND}). Compared with standard SRTM, either coupling of k{sup r}{sub 2} across regions or constraining k{sup r}{sub 2} to a first-pass estimate improved the sensitivity of SRTM to measuring a significant difference in BP{sub ND} between patients and controls. Parameter coupling was particularly effective in reducing the variance of parameter estimates, which was less than 50% of the variance obtained with standard SRTM. A linear approach was also improved when constraining k{sup r}{sub 2} to a first-pass estimate, although the SRTM-based methods yielded stronger significant differences when applied to the clinical study. This work shows that parameter coupling reduces the

  6. Scaling the heterogeneously heated convective boundary layer

    Science.gov (United States)

    Van Heerwaarden, C.; Mellado, J.; De Lozar, A.

    2013-12-01

    We have studied the heterogeneously heated convective boundary layer (CBL) by means of large-eddy simulations (LES) and direct numerical simulations (DNS). What makes our study different from previous studies on this subject are our very long simulations in which the system travels through multiple states and that from there we have derived scaling laws. In our setup, a stratified atmosphere is heated from below by square patches with a high surface buoyancy flux, surrounded by regions with no or little flux. By letting a boundary layer grow in time we let the system evolve from the so-called meso-scale to the micro-scale regime. In the former the heterogeneity is large and strong circulations can develop, while in the latter the heterogeneity is small and does no longer influence the boundary layer structure. Within each simulation we can now observe the formation of a peak in kinetic energy, which represents the 'optimal' heterogeneity size in the meso-scale, and the subsequent decay of the peak and the development towards the transition to the micro-scale. We have created a non-dimensional parameter space that describes all properties of this system. By studying the previously described evolution for different combinations of parameters, we have derived three important conclusions. First, there exists a horizontal length scale of the heterogeneity (L) that is a function of the boundary layer height (h) and the Richardson (Ri) number of the inversion at the top of the boundary layer. This relationship has the form L = h Ri^(3/8). Second, this horizontal length scale L allows for expressing the time evolution, and thus the state of the system, as a ratio of this length scale and the distance between two patches Xp. This ratio thus describes to which extent the circulation fills up the space that exists between two patch centers. The timings of the transition from the meso- to the micro-scale collapse under this scaling for all simulations sharing the same flux

  7. Desert plains classification based on Geomorphometrical parameters (Case study: Aghda, Yazd)

    Science.gov (United States)

    Tazeh, mahdi; Kalantari, Saeideh

    2013-04-01

    This research focuses on plains. There are several tremendous methods and classification which presented for plain classification. One of The natural resource based classification which is mostly using in Iran, classified plains into three types, Erosional Pediment, Denudation Pediment Aggradational Piedmont. The qualitative and quantitative factors to differentiate them from each other are also used appropriately. In this study effective Geomorphometrical parameters in differentiate landforms were applied for plain. Geomorphometrical parameters are calculable and can be extracted using mathematical equations and the corresponding relations on digital elevation model. Geomorphometrical parameters used in this study included Percent of Slope, Plan Curvature, Profile Curvature, Minimum Curvature, the Maximum Curvature, Cross sectional Curvature, Longitudinal Curvature and Gaussian Curvature. The results indicated that the most important affecting Geomorphometrical parameters for plain and desert classifications includes: Percent of Slope, Minimum Curvature, Profile Curvature, and Longitudinal Curvature. Key Words: Plain, Geomorphometry, Classification, Biophysical, Yazd Khezarabad.

  8. A systematic study of distribution characters of infiltration parameters in an experimental basin by nuclear methods

    International Nuclear Information System (INIS)

    Gu Weizu; Lu Jieju; Lu Mingjiang; Chen Tingyang

    1988-01-01

    A case study of spatial variability of Philip's infiltration parameters was carried out in a small experimental catchment with an area of 0.8 ha by nuclear monitoring methods. Relationships between sorptivity S, parameter A and the average initial soil water content within 0.5 m depth of soil profiles over the catchment have been plotted. A watershed infiltration parameter distribution curve is set up and fitted approximately by f/F=1-(1-S/S M ) n . The parameters of composite infiltration response related to whole catchment are suggested. The author has studied it on an experimental basin by combined method of nuclear technology and micro-geomorphic analysis. The results are satisfactory. (author). 6 refs, 11 figs, 2 tabs

  9. A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions.

    Directory of Open Access Journals (Sweden)

    Darina Čejková

    Full Text Available Pathogenic uncultivable treponemes comprise human and animal pathogens including agents of syphilis, yaws, bejel, pinta, and venereal spirochetosis in rabbits and hares. A set of 10 treponemal genome sequences including those of 4 Treponema pallidum ssp. pallidum (TPA strains (Nichols, DAL-1, Mexico A, SS14, 4 T. p. ssp. pertenue (TPE strains (CDC-2, Gauthier, Samoa D, Fribourg-Blanc, 1 T. p. ssp. endemicum (TEN strain (Bosnia A and one strain (Cuniculi A of Treponema paraluisleporidarum ecovar Cuniculus (TPLC were examined with respect to the presence of nucleotide intrastrain heterogeneous sites.The number of identified intrastrain heterogeneous sites in individual genomes ranged between 0 and 7. Altogether, 23 intrastrain heterogeneous sites (in 17 genes were found in 5 out of 10 investigated treponemal genomes including TPA strains Nichols (n = 5, DAL-1 (n = 4, and SS14 (n = 7, TPE strain Samoa D (n = 1, and TEN strain Bosnia A (n = 5. Although only one heterogeneous site was identified among 4 tested TPE strains, 16 such sites were identified among 4 TPA strains. Heterogeneous sites were mostly strain-specific and were identified in four tpr genes (tprC, GI, I, K, in genes involved in bacterial motility and chemotaxis (fliI, cheC-fliY, in genes involved in cell structure (murC, translation (prfA, general and DNA metabolism (putative SAM dependent methyltransferase, topA, and in seven hypothetical genes.Heterogeneous sites likely represent both the selection of adaptive changes during infection of the host as well as an ongoing diversifying evolutionary process.

  10. A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions.

    Science.gov (United States)

    Čejková, Darina; Strouhal, Michal; Norris, Steven J; Weinstock, George M; Šmajs, David

    2015-01-01

    Pathogenic uncultivable treponemes comprise human and animal pathogens including agents of syphilis, yaws, bejel, pinta, and venereal spirochetosis in rabbits and hares. A set of 10 treponemal genome sequences including those of 4 Treponema pallidum ssp. pallidum (TPA) strains (Nichols, DAL-1, Mexico A, SS14), 4 T. p. ssp. pertenue (TPE) strains (CDC-2, Gauthier, Samoa D, Fribourg-Blanc), 1 T. p. ssp. endemicum (TEN) strain (Bosnia A) and one strain (Cuniculi A) of Treponema paraluisleporidarum ecovar Cuniculus (TPLC) were examined with respect to the presence of nucleotide intrastrain heterogeneous sites. The number of identified intrastrain heterogeneous sites in individual genomes ranged between 0 and 7. Altogether, 23 intrastrain heterogeneous sites (in 17 genes) were found in 5 out of 10 investigated treponemal genomes including TPA strains Nichols (n = 5), DAL-1 (n = 4), and SS14 (n = 7), TPE strain Samoa D (n = 1), and TEN strain Bosnia A (n = 5). Although only one heterogeneous site was identified among 4 tested TPE strains, 16 such sites were identified among 4 TPA strains. Heterogeneous sites were mostly strain-specific and were identified in four tpr genes (tprC, GI, I, K), in genes involved in bacterial motility and chemotaxis (fliI, cheC-fliY), in genes involved in cell structure (murC), translation (prfA), general and DNA metabolism (putative SAM dependent methyltransferase, topA), and in seven hypothetical genes. Heterogeneous sites likely represent both the selection of adaptive changes during infection of the host as well as an ongoing diversifying evolutionary process.

  11. Thermal Hydraulic design parameters study for severe accidents using neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Roh, Chang Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Chang, Keun Sun [Sunmoon University, Asan (Korea, Republic of)

    1997-12-31

    To provide the information on severe accident progression is very important for advanced or new type of nuclear power plant (NPP) design. A parametric study, therefore, was performed to investigate the effect of thermal hydraulic design parameters on severe accident progression of pressurized water reactors (PWRs). Nine parameters, which are considered important in NPP design or severe accident progression, were selected among the various thermal hydraulic design parameters. The backpropagation neural network (BPN) was used to determine parameters, which might more strongly affect the severe accident progression, among nine parameters. For training, different input patterns were generated by the latin hypercube sampling (LHS) technique and then different target patterns that contain core uncovery time and vessel failure time were obtained for Young Gwang Nuclear (YGN) Units 3 and 4 using modular accident analysis program (MAAP) 3.0B code. Three different severe accident scenarios, such as two loss of coolant accidents (LOCAs) and station blackout (SBO), were considered in this analysis. Results indicated that design parameters related to refueling water storage tank (RWST), accumulator and steam generator (S/G) have more dominant effects on the progression of severe accidents investigated, compared to the other six parameters. 9 refs., 5 tabs. (Author)

  12. Thermal Hydraulic design parameters study for severe accidents using neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Roh, Chang Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Chang, Keun Sun [Sunmoon University, Asan (Korea, Republic of)

    1998-12-31

    To provide the information on severe accident progression is very important for advanced or new type of nuclear power plant (NPP) design. A parametric study, therefore, was performed to investigate the effect of thermal hydraulic design parameters on severe accident progression of pressurized water reactors (PWRs). Nine parameters, which are considered important in NPP design or severe accident progression, were selected among the various thermal hydraulic design parameters. The backpropagation neural network (BPN) was used to determine parameters, which might more strongly affect the severe accident progression, among nine parameters. For training, different input patterns were generated by the latin hypercube sampling (LHS) technique and then different target patterns that contain core uncovery time and vessel failure time were obtained for Young Gwang Nuclear (YGN) Units 3 and 4 using modular accident analysis program (MAAP) 3.0B code. Three different severe accident scenarios, such as two loss of coolant accidents (LOCAs) and station blackout (SBO), were considered in this analysis. Results indicated that design parameters related to refueling water storage tank (RWST), accumulator and steam generator (S/G) have more dominant effects on the progression of severe accidents investigated, compared to the other six parameters. 9 refs., 5 tabs. (Author)

  13. Comparative study of methods to estimate hydraulic parameters in the hydraulically undisturbed Opalinus Clay (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, C.; Matray, J.-M. [Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, (France); Yu, C.; Gonçalvès, J. [Aix Marseille Université UMR 6635 CEREGE Technopôle Environnement Arbois-Méditerranée Aix-en-Provence, Cedex 4 (France); and others

    2017-04-15

    The deep borehole (DB) experiment gave the opportunity to acquire hydraulic parameters in a hydraulically undisturbed zone of the Opalinus Clay at the Mont Terri rock laboratory (Switzerland). Three methods were used to estimate hydraulic conductivity and specific storage values of the Opalinus Clay formation and its bounding formations through the 248 m deep borehole BDB-1: application of a Poiseuille-type law involving petrophysical measurements, spectral analysis of pressure time series and in situ hydraulic tests. The hydraulic conductivity range in the Opalinus Clay given by the first method is 2 × 10{sup -14}-6 × 10{sup -13} m s{sup -1} for a cementation factor ranging between 2 and 3. These results show low vertical variability whereas in situ hydraulic tests suggest higher values up to 7 × 10{sup -12} m s{sup -1}. Core analysis provides economical estimates of the homogeneous matrix hydraulic properties but do not account for heterogeneities at larger scale such as potential tectonic conductive features. Specific storage values obtained by spectral analysis are consistent and in the order of 10{sup -6} m{sup -1}, while formulations using phase shift and gain between pore pressure signals were found to be inappropriate to evaluate hydraulic conductivity in the Opalinus Clay. The values obtained are globally in good agreement with the ones obtained previously at the rock laboratory. (authors)

  14. A study of the infrared spectrum of psi Persei .1. A parameter study of the disc model

    NARCIS (Netherlands)

    Marlborough, JM; Waters, LBFM

    We report a parameter study of emission lines arising from a disc surrounding a Be star, using parameters appropriate to the Be star psi Per. We concentrate on the Hn line and on some IR recombination lines (Br alpha, Br gamma, Pf gamma, and HI 17-6). The model we use is a simple cone-like disc

  15. Conceptual analysis of single-feed heterogeneous distillation columns

    Directory of Open Access Journals (Sweden)

    Carlos Arturo Martinez Riascos

    2015-05-01

    Full Text Available Separation in heterogeneous distillation columns is attained by interaction of two liquid and one vapor phases, interaction of three phases involves complexities due to the determination of vapor-liquid-liquid equilibrium and hence, in the design of separation units. Nevertheless, the liquid-liquid equilibrium allows developing separations that may be unfeasible by vapor-liquid equilibrium. In this way, heterogeneous azeotropic distillation is a useful operation for the separation of azeotropic and close-boiling mixtures. In this work, a new methodology for evaluating the feasibility of this process is developed. This methodology is an extension of that proposed by Castillo et al. (1998 for homogeneous systems. Operation leaves for heterogeneous systems are calculated using the concept of pinch point curves in order to establish the process feasibility. Heterogeneous columns with external decanter are considered as the only heterogeneous stage (OHED: only heterogeneous external decanter. The initialization process for the column calculation requires the selection of the distillate composition using thermodynamic criteria in order to guarantee homogeneous phases within the column. A system with industrial and academic relevance was considered as case study: water-acetic acid-amyl acetate. Results show that the developed shortcut method allows evaluating process feasibility and estimating design parameters, without the use of trial and error procedures implemented, with the aid of simulation tools.

  16. The effect of uphill and downhill walking on gait parameters: A self-paced treadmill study.

    Science.gov (United States)

    Kimel-Naor, Shani; Gottlieb, Amihai; Plotnik, Meir

    2017-07-26

    It has been shown that gait parameters vary systematically with the slope of the surface when walking uphill (UH) or downhill (DH) (Andriacchi et al., 1977; Crowe et al., 1996; Kawamura et al., 1991; Kirtley et al., 1985; McIntosh et al., 2006; Sun et al., 1996). However, gait trials performed on inclined surfaces have been subject to certain technical limitations including using fixed speed treadmills (TMs) or, alternatively, sampling only a few gait cycles on inclined ramps. Further, prior work has not analyzed upper body kinematics. This study aims to investigate effects of slope on gait parameters using a self-paced TM (SPTM) which facilitates more natural walking, including measuring upper body kinematics and gait coordination parameters. Gait of 11 young healthy participants was sampled during walking in steady state speed. Measurements were made at slopes of +10°, 0° and -10°. Force plates and a motion capture system were used to reconstruct twenty spatiotemporal gait parameters. For validation, previously described parameters were compared with the literature, and novel parameters measuring upper body kinematics and bilateral gait coordination were also analyzed. Results showed that most lower and upper body gait parameters were affected by walking slope angle. Specifically, UH walking had a higher impact on gait kinematics than DH walking. However, gait coordination parameters were not affected by walking slope, suggesting that gait asymmetry, left-right coordination and gait variability are robust characteristics of walking. The findings of the study are discussed in reference to a potential combined effect of slope and gait speed. Follow-up studies are needed to explore the relative effects of each of these factors. Copyright © 2017. Published by Elsevier Ltd.

  17. IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.

    Science.gov (United States)

    Tyagi, Anil K; Randolph, Theodore W; Dong, Aichun; Maloney, Kevin M; Hitscherich, Carl; Carpenter, John F

    2009-01-01

    This study investigated factors associated with vial filling with a positive displacement piston pump leading to formation of protein particles in a formulation of an IgG. We hypothesized that nanoparticles shed from the pump's solution-contact surfaces nucleated protein aggregation and particle formation. Vials of IgG formulation filled at a clinical manufacturing site contained a few visible particles and about 100,000 particles (1.5-3 microm) per mL. In laboratory studies with the same model (National Instruments FUS-10) of pump, pumping of 20 mg/mL IgG formulation resulted in about 300,000 particles (1.5-3 microm) per mL. Pumping of protein-free formulation resulted in 13,000 particles (1.5-15 microm) per mL. More than 99% of the particles were 0.25-0.95 microm in size. Mixing of protein-free pumped solution with an equal volume of 40 mg/mL IgG resulted in 300,000 particles (1.5-15 microm) per mL. Also, mixing IgG formulation with 30,000/mL stainless steel nanoparticles resulted in formation of 30,000 protein microparticles (1.5-15 microm) per mL. Infrared spectroscopy showed that secondary structure of IgG in microparticles formed by pumping or mixing with steel nanoparticles was minimally perturbed. Our results document that nanoparticles of foreign materials shed by pumps can serve as heterogeneous nuclei for formation of protein microparticles. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association

  18. Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study: Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography

    Institute of Scientific and Technical Information of China (English)

    Hua-Guang Zheng; Rong Zhang; Xin Li; Fang-Fei Li; Ya-Chen Wang; Xue-Mei Wang; Ling-Long Lu

    2015-01-01

    Background:The relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD) remains controversial.In this study,we aimed to assess the function ofpresynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography (DAT-PET) and to evaluate the utility of clinical features or electrophysiological studies in differential diagnosis.Methods:Thirty-three consecutive patients with mRT were enrolled prospectively.The Unified Parkinson's Disease Rating Scale and electromyography were tested before DAT-PET.Striatal asymmetry index (SAI) was calculated,and a normal DAT-PET was defined as a SAI of <15%.Scans without evidence of dopaminergic deficits (SWEDDs) were diagnosed in patients with a subsequent normal DAT-PET and structural magnetic resonance imaging.Results:Twenty-eight mRT patients with a significant reduction in uptake of DAT binding in the striatum were diagnosed with PD,while the remained 5 with a normal DAT-PET scan were SWEDDs.As for UPRDS,the dressing and hygiene score,walking in motor experiences of daily living (Part Ⅱ) and motor examination (Part Ⅲ) were significant different between two groups (P < 0.05 andP< 0.01,respectively).Bilateral tremor was more frequent in the SWEDDs group (P < 0.05).The frequency of resting tremor and the amplitude of postural tremor tend to be higher in the SWEDDs group (P =0.08 and P =0.05,respectively).Conclusions:mRT is heterogeneous in presynaptic nigrostriatal dopaminergic degeneration,which can be determined by DAT-PET brain imaging.Clinical and electrophysiological features may provide clues to distinguish PD from SWEDDs.

  19. Heterogeneous Photochemistry of Agrochemicals at the Leaf Surface: A Case Study of Plant Activator Acibenzolar-S-methyl.

    Science.gov (United States)

    Sleiman, M; de Sainte Claire, P; Richard, C

    2017-09-06

    The photoreactivity of plant activator benzo(1,2,3)thiadiazole-7-carbothioic acid S-methyl ester (BTH), commonly named acibenzolar-S-methyl, was studied on the surfaces of glass, paraffinic wax films, and apple leaves. Experiments were carried out in a solar simulator using pure and formulated BTH (BION). Surface photoproducts were identified using liquid chromatography coupled with electrospray ionization and high-resolution Orbitrap mass spectrometry, while volatile photoproducts were characterized using an online thermal desorption system coupled to a gas chromatography-mass spectrometry (GC-MS) system. Pure BTH degraded quickly on wax surfaces with a half-life of 5.0 ± 0.5 h, whereas photolysis of formulated BTH was 7 times slower (t 1/2 = 36 ± 14 h). On the other hand, formulated BTH was found to photolyze quickly on detached apple leaves with a half-life of 2.8 h ± 0.4 h. This drastic difference in photoreactivity was attributed to the nature and spreading of the BTH deposit, as influenced by the surfactant and surface characteristics. Abiotic stress of irradiated apple leaf was also shown to produce OH radicals which might contribute to the enhanced photodegradability. Eight surface photoproducts were identified, whereas GC-MS analyses revealed the formation of gaseous dimethyl disulfide and methanethiol. The yield of dimethyl disulfide ranged between 1.5% and 12%, and a significant fraction of dimethyl disulfide produced was found to be absorbed by the leaf. This is the first study to report on the formation of volatile chemicals and OH radicals during agrochemical photolysis on plant surfaces. The developed experimental approach can provide valuable insights into the heterogeneous photoreactivity of sprayed agrochemicals and could help improve dissipation models.

  20. Imaging metabolic heterogeneity in cancer.

    Science.gov (United States)

    Sengupta, Debanti; Pratx, Guillem

    2016-01-06

    As our knowledge of cancer metabolism has increased, it has become apparent that cancer metabolic processes are extremely heterogeneous. The reasons behind this heterogeneity include genetic diversity, the existence of multiple and redundant metabolic pathways, altered microenvironmental conditions, and so on. As a result, methods in the clinic and beyond have been developed in order to image and study tumor metabolism in the in vivo and in vitro regimes. Both regimes provide unique advantages and challenges, and may be used to provide a picture of tumor metabolic heterogeneity that is spatially and temporally comprehensive. Taken together, these methods may hold the key to appropriate cancer diagnoses and treatments in the future.

  1. CORRELATION STUDY AMONG WATER QUALITY PARAMETERS OF GROUNDWATER OF VALSAD DISTRICT OF SOUTH GUJARAT(INDIA

    Directory of Open Access Journals (Sweden)

    R. T. Vashi

    2015-09-01

    Full Text Available Groundwater samples were collected from five talukas of Valsad district for one year (from August 2008 to July 2009 and were analyzed for their physicochemical characteristics.  The present investigation is focused on  determination of parameters like pH, Colour, Electrical Conductivity (EC, Total Hardness (TH, Calcium (Ca, Magnesium (Mg, Total Alkalinity (TA, Total Dissolved Solids (TDS, Silica, Chloride, Sulphate, Fluoride, Sodium, Chemical Oxygen Demand (COD and metals like Copper (Cu and Manganese (Mn.  Correlation coefficients were determined to identify the highly correlated parameters and interrelated water quality parameters. Correlation matrix of Valsad district suggests that EC of groundwater is found to be significantly correlated with eight out of seventeen water quality parameters studied.  It may be suggested that the quality of Valsad district can be checked very effectively by controlling EC of water.

  2. Determination of a PWR key neutron parameters uncertainties and conformity studies applications

    International Nuclear Information System (INIS)

    Bernard, D.

    2002-01-01

    The aim of this thesis was to evaluate uncertainties of key neutron parameters of slab reactors. Uncertainties sources have many origins, technologic origin for parameters of fabrication and physical origin for nuclear data. First, each contribution of uncertainties is calculated and finally, a factor of uncertainties is associated to key slab parameter like reactivity, isotherm reactivity coefficient, control rod efficiency, power form factor before irradiation and lifetime. This factors of uncertainties were computed by Generalized Perturbations Theory in case of step 0 and by directs calculations in case of irradiation problems. One of neutronic conformity applications was about fabrication and nuclear data targets precision adjustments. Statistic (uncertainties) and deterministic (deviations) approaches were studied. Then neutronics key slab parameters uncertainties were reduced and so nuclear performances were optimised. (author)

  3. The mechanical heterogeneity of the hard callus influences local tissue strains during bone healing: a finite element study based on sheep experiments.

    Science.gov (United States)

    Vetter, A; Liu, Y; Witt, F; Manjubala, I; Sander, O; Epari, D R; Fratzl, P; Duda, G N; Weinkamer, R

    2011-02-03

    During secondary fracture healing, various tissue types including new bone are formed. The local mechanical strains play an important role in tissue proliferation and differentiation. To further our mechanobiological understanding of fracture healing, a precise assessment of local strains is mandatory. Until now, static analyses using Finite Elements (FE) have assumed homogenous material properties. With the recent quantification of both the spatial tissue patterns (Vetter et al., 2010) and the development of elastic modulus of newly formed bone during healing (Manjubala et al., 2009), it is now possible to incorporate this heterogeneity. Therefore, the aim of this study is to investigate the effect of this heterogeneity on the strain patterns at six successive healing stages. The input data of the present work stemmed from a comprehensive cross-sectional study of sheep with a tibial osteotomy (Epari et al., 2006). In our FE model, each element containing bone was described by a bulk elastic modulus, which depended on both the local area fraction and the local elastic modulus of the bone material. The obtained strains were compared with the results of hypothetical FE models assuming homogeneous material properties. The differences in the spatial distributions of the strains between the heterogeneous and homogeneous FE models were interpreted using a current mechanobiological theory (Isakson et al., 2006). This interpretation showed that considering the heterogeneity of the hard callus is most important at the intermediate stages of healing, when cartilage transforms to bone via endochondral ossification. Copyright © 2010 Elsevier Ltd. All rights reserved.

  4. Study of an optimization approach for a disposal tunnel layout, taking into account the geological environment with spatially heterogeneous characteristics

    International Nuclear Information System (INIS)

    Suyama, Yasuhiro; Toida, Masaru; Yanagizawa, Koichi

    2009-01-01

    The geological environment has spatially heterogeneous characteristics with varied host rock types, fractures and so on. In this case the generic disposal tunnel layout, which has been designed by JNC, is not the most suitable for HLW disposal in Japan. The existence of spatially heterogeneous characteristics means that in the repository region there exist sub-regions that are more favourable from the perspective of long-term safety and ones that are less favourable. In order that the spatially heterogeneous environment itself may be utilized most effectively as a natural barrier system, an alternative design of disposal tunnel layout is required. Focusing on the geological environment with spatially heterogeneous characteristics, the authors have developed an alternative design of disposal tunnel layout. The alternative design adopts an optimization approach using a variable disposal tunnel layout. The optimization approach minimizes the number of locations where major water-conducting fractures are intersected, and maximizes the number of emplacement locations for waste packages. This paper will outline the variable disposal tunnel layout and its applicability.

  5. Disentangling the effects of root foraging and inherent growth rate on plant biomass accumulation in heterogeneous environments : a modelling study

    NARCIS (Netherlands)

    Fransen, B.; Kroon, de H.; Kovel, de C.G.F.; Bosch, van den F.

    1999-01-01

    Empirical evidence indicates that fast-growing species generally display a higher degree of selective root placement in heterogeneous environments than slow-growing species. Such root foraging is accomplished by root morphological responses, but since some morphological responses are simply the

  6. A Mindfulness-Based Compassionate Living Training in a Heterogeneous Sample of Psychiatric Outpatients : a Feasibility Study

    NARCIS (Netherlands)

    Bartels-Velthuis, Agna A.; Schroevers, Maya J.; van der Ploeg, Karen; Koster, Frits; Fleer, Joke; van den Brink, Erik

    We developed a novel compassion-focused training (mindfulness-based compassionate living; MBCL) and examined its effects in a heterogeneous psychiatric outpatient population with regard to feasibility and changes in levels of depression, anxiety, mindfulness and compassion. The training consisted of

  7. Normal Values for Heart Electrophysiology Parameters of Healthy Swine Determined on Electrophysiology Study.

    Science.gov (United States)

    Noszczyk-Nowak, Agnieszka; Cepiel, Alicja; Janiszewski, Adrian; Pasławski, Robert; Gajek, Jacek; Pasławska, Urszula; Nicpoń, Józef

    2016-01-01

    Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine. The study included 36 healthy domestic swine (24-40 kg body weight). EPS was performed under a general anesthesia with midazolam, propofol and isoflurane. The reference values for intracardiac electrical activity and conduction parameters were calculated as arithmetic means ± 2 standard deviations. The reference values were determined for AH, HV and PA intervals, interatrial conduction time at its own and imposed rhythm, sinus node recovery time (SNRT), corrected sinus node recovery time (CSNRT), anterograde and retrograde Wenckebach points, atrial, atrioventricular node and ventricular refractory periods. No significant correlations were found between body weight and heart rate of the examined pigs and their electrophysiological parameters. The hereby presented reference values can be helpful in comparing the results of various studies, as well as in more accurately estimating the values of electrophysiological parameters that can be expected in a given experiment.

  8. Mathematical modelling of simultaneous solvent evaporation and chemical curing in thermoset coatings: A parameter study

    DEFF Research Database (Denmark)

    Kiil, Søren

    2011-01-01

    A mathematical model, describing the curing behaviour of a two-component, solvent-based, thermoset coating, is used to conduct a parameter study. The model includes curing reactions, solvent intra-film diffusion and evaporation, film gelation, vitrification, and crosslinking. A case study with a ...

  9. The Legion Support for Advanced Parameter-Space Studies on a Grid

    National Research Council Canada - National Science Library

    Natrajan, Anand; Humphrey, Marty A; Grimshaw, Andrew S

    2006-01-01

    .... Legion provides tools and services that support advanced parameter-space studies, i.e., studies that make complex demands such as transparent access to distributed files, fault-tolerance and security. We demonstrate these benefits with a protein-folding experiment in which a molecular simulation package was run over a grid managed by Legion.

  10. A System for Extracting Study Design Parameters from Nutritional Genomics Abstracts

    Directory of Open Access Journals (Sweden)

    Kelly Cassidy

    2013-06-01

    Full Text Available The extraction of study design parameters from biomedical journal articles is an important problem in natural language processing (NLP. Such parameters define the characteristics of a study, such as the duration, the number of subjects, and their profile. Here we present a system for extracting study design parameters from sentences in article abstracts. This system will be used as a component of a larger system for creating nutrigenomics networks from articles in the nutritional genomics domain. The algorithms presented consist of manually designed rules expressed either as regular expressions or in terms of sentence parse structure. A number of filters and NLP tools are also utilized within a pipelined algorithmic framework. Using this novel approach, our system performs extraction at a finer level of granularity than comparable systems, while generating results that surpass the current state of the art.

  11. Exploratory Study for Continuous-time Parameter Estimation of Ankle Dynamics

    Science.gov (United States)

    Kukreja, Sunil L.; Boyle, Richard D.

    2014-01-01

    Recently, a parallel pathway model to describe ankle dynamics was proposed. This model provides a relationship between ankle angle and net ankle torque as the sum of a linear and nonlinear contribution. A technique to identify parameters of this model in discrete-time has been developed. However, these parameters are a nonlinear combination of the continuous-time physiology, making insight into the underlying physiology impossible. The stable and accurate estimation of continuous-time parameters is critical for accurate disease modeling, clinical diagnosis, robotic control strategies, development of optimal exercise protocols for longterm space exploration, sports medicine, etc. This paper explores the development of a system identification technique to estimate the continuous-time parameters of ankle dynamics. The effectiveness of this approach is assessed via simulation of a continuous-time model of ankle dynamics with typical parameters found in clinical studies. The results show that although this technique improves estimates, it does not provide robust estimates of continuous-time parameters of ankle dynamics. Due to this we conclude that alternative modeling strategies and more advanced estimation techniques be considered for future work.

  12. Study on Material Parameters Identification of Brain Tissue Considering Uncertainty of Friction Coefficient

    Science.gov (United States)

    Guan, Fengjiao; Zhang, Guanjun; Liu, Jie; Wang, Shujing; Luo, Xu; Zhu, Feng

    2017-10-01

    Accurate material parameters are critical to construct the high biofidelity finite element (FE) models. However, it is hard to obtain the brain tissue parameters accurately because of the effects of irregular geometry and uncertain boundary conditions. Considering the complexity of material test and the uncertainty of friction coefficient, a computational inverse method for viscoelastic material parameters identification of brain tissue is presented based on the interval analysis method. Firstly, the intervals are used to quantify the friction coefficient in the boundary condition. And then the inverse problem of material parameters identification under uncertain friction coefficient is transformed into two types of deterministic inverse problem. Finally the intelligent optimization algorithm is used to solve the two types of deterministic inverse problems quickly and accurately, and the range of material parameters can be easily acquired with no need of a variety of samples. The efficiency and convergence of this method are demonstrated by the material parameters identification of thalamus. The proposed method provides a potential effective tool for building high biofidelity human finite element model in the study of traffic accident injury.

  13. Intratumoural evolutionary landscape of high-risk prostate cancer: The PROGENY study of genomic and immune parameters

    DEFF Research Database (Denmark)

    Linch, M.; Goh, G.; Hiley, C.

    2017-01-01

    Background: Intratumoural heterogeneity (ITH) is well recognised in prostate cancer (PC), but its role in high-risk disease is uncertain. A prospective, single-arm, translational study using targeted multiregion prostate biopsies was carried out to study genomic and T-cell ITH in clinically high-...

  14. Study on Identification of Material Model Parameters from Compact Tension Test on Concrete Specimens

    Science.gov (United States)

    Hokes, Filip; Kral, Petr; Husek, Martin; Kala, Jiri

    2017-10-01

    Identification of a concrete material model parameters using optimization is based on a calculation of a difference between experimentally measured and numerically obtained data. Measure of the difference can be formulated via root mean squared error that is often used for determination of accuracy of a mathematical model in the field of meteorology or demography. The quality of the identified parameters is, however, determined not only by right choice of an objective function but also by the source experimental data. One of the possible way is to use load-displacement curves from three-point bending tests that were performed on concrete specimens. This option shows the significance of modulus of elasticity, tensile strength and specific fracture energy. Another possible option is to use experimental data from compact tension test. It is clear that the response in the second type of test is also dependent on the above mentioned material parameters. The question is whether the parameters identified within three-point bending test and within compact tension test will reach the same values. The presented article brings the numerical study of inverse identification of material model parameters from experimental data measured during compact tension tests. The article also presents utilization of the modified sensitivity analysis that calculates the sensitivity of the material model parameters for different parts of loading curve. The main goal of the article is to describe the process of inverse identification of parameters for plasticity-based material model of concrete and prepare data for future comparison with identified values of the material model parameters from different type of fracture tests.

  15. Thermal-Hydraulic Sensitivity Study of Intermediate Loop Parameters for Nuclear Hydrogen Production System

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jong Hwa; Lee, Heung Nae; Park, Jea Ho [KONES Corp., Seoul (Korea, Republic of); Lee, Won Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Sang Il; Yoo, Yeon Jae [Hyundai Engineering Co., Seoul (Korea, Republic of)

    2016-10-15

    The heat generated from the VHTR is transferred to the intermediate loop through Intermediate Heat Exchanger (IHX). It is further passed on to the Sulfur-Iodine (SI) hydrogen production system (HPS) through Process Heat Exchanger (PHX). The IL provides the safety distance between the VHTR and HPS. Since the IL performance affects the overall nuclear HPS efficiency, it is required to optimize its design and operation parameters. In this study, the thermal-hydraulic sensitivity of IL parameters with various coolant options has been examined by using MARS-GCR code, which was already applied for the case of steam generator. Sensitivity study of the IL and PHX parameters has been carried out based on their thermal-hydraulic performance. Several parameters for design and operation, such as the pipe diameter, safety distance and surface area, are considered for different coolant options, He, CO{sub 2} and He-CO{sub 2} (2:8). It was found that the circulator work is the major factor affecting on the overall nuclear hydrogen production system efficiency. Circulator work increases with the safety distance, and decreases with the operation pressure and loop pipe diameter. Sensitivity results obtained from this study will contribute to the optimization of the IL design and operation parameters and the optimal coolant selection.

  16. Comparative Study of Plasma Parameters in Olive Ridley (Lepidochelys Olivacea and Hawksbill (Eretmochelys Imbricata During Nesting

    Directory of Open Access Journals (Sweden)

    A.Y.A. Alkindi

    2002-06-01

    Full Text Available The aim of this study is to investigate the role of plasma level parameters during nesting activity and provide data potentially useful to future studies on the dynamics of reproductive and stress hormones in the most endangered sea turtle species in the world. Plasma parameters in the sea turtles, olive ridley (Lipodochelys oliveacea and hawksbill (Eretmochelys imbricata from Masirah Island, Oman, were analyzed relative to nesting stress. To date, no study has been conducted on plasma parameter levels in sea turtles during nesting. Field observations were conducted under ideal temperature conditions. At the time of sampling, there was no significant difference for cloacal, sand, air or water temperature for the two species. Electrolytes (Cl¯, Ca++, K+, Na+ and Mg++, cholesterol, urea, uric acid and osmolarity were measured during nesting. Both species were observed to spend between 1.5 and 2.00 hours on the nesting grounds. Some had successful oviposition and completed all nesting phases, while others with incomplete nesting phases failed to oviposit their  eggs. Under both conditions, the turtles of both species had an exhaustive and stressful nesting exercise. Plasma parameter values, both intra-specifically and inter-specifically, were not significantly different for oviposited and non-oviposited turtles. This may indicate that both species have the same physiological adjustment relative to plasma parameters whether or not the turtles oviposited their eggs.

  17. Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Ernst, Anja; Sventoraityte, Jurgita

    2011-01-01

    the combined Baltic, Danish, and Norwegian panel versus the combined German, British, Belgian, and Greek panel (rs7520292 (P = 0.001), rs12518307 (P = 0.007), and rs2395609 (TCP11) (P = 0.01), respectively). No SNP reached genome-wide significance in the combined analyses of all the panels. Conclusions......Background: Differences in the genetic architecture of inflammatory bowel disease between different European countries and ethnicities have previously been reported. In the present study, we wanted to assess the role of 11 newly identified UC risk variants, derived from a recent European UC genome...... wide association study (GWAS) (Franke et al., 2010), for 1) association with UC in the Nordic countries, 2) for population heterogeneity between the Nordic countries and the rest of Europe, and, 3) eventually, to drive some of the previous findings towards overall genome-wide significance. Methods...

  18. Studies of Some Parameters Affecting The Efficiency and Accuracy of The Neutron Activation Analysis Technique

    International Nuclear Information System (INIS)

    Abdel-Haleem, A.S.; Zaghloul, R.A.; Sroor, A.; Abdel Sabour, M.F.

    2000-01-01

    The present studies deal with the optimum physical conditions which seriously affect the neutron activation analysis technique efficiency. An experimental work for the efficiency calibration of hyper pure germanium detectors especially for environmental studies is presented. This work showed that the tested parameters, under consideration, distance, mass and measured time, reveal a significant effect on the obtained data. These results, intern, affect the accuracy of the measurements. Further work on the test of other parameters is planned in our laboratory using special treatments and applying special computer programs

  19. Statistical study of chorus wave distributions in the inner magnetosphere using Ae and solar wind parameters

    Science.gov (United States)

    Aryan, Homayon; Yearby, Keith; Balikhin, Michael; Agapitov, Oleksiy; Krasnoselskikh, Vladimir; Boynton, Richard

    2014-08-01

    Energetic electrons within the Earth's radiation belts represent a serious hazard to geostationary satellites. The interactions of electrons with chorus waves play an important role in both the acceleration and loss of radiation belt electrons. The common approach is to present model wave distributions in the inner magnetosphere under different values of geomagnetic activity as expressed by the geomagnetic indices. However, it has been shown that only around 50% of geomagnetic storms increase flux of relativistic electrons at geostationary orbit while 20% causes a decrease and the remaining 30% has relatively no effect. This emphasizes the importance of including solar wind parameters such as bulk velocity (V), density (n), flow pressure (P), and the vertical interplanetary magnetic field component (Bz) that are known to be predominately effective in the control of high energy fluxes at the geostationary orbit. Therefore, in the present study the set of parameters of the wave distributions is expanded to include the solar wind parameters in addition to the geomagnetic activity. The present study examines almost 4 years (1 January 2004 to 29 September 2007) of Spatio-Temporal Analysis of Field Fluctuation data from Double Star TC1 combined with geomagnetic indices and solar wind parameters from OMNI database in order to present a comprehensive model of wave magnetic field intensities for the chorus waves as a function of magnetic local time, L shell (L), magnetic latitude (λm), geomagnetic activity, and solar wind parameters. Generally, the results indicate that the intensity of chorus emission is not only dependent upon geomagnetic activity but also dependent on solar wind parameters with velocity and southward interplanetary magnetic field Bs (Bz < 0), evidently the most influential solar wind parameters. The largest peak chorus intensities in the order of 50 pT are observed during active conditions, high solar wind velocities, low solar wind densities, high

  20. The effect of soil heterogeneity on ATES performance

    Science.gov (United States)

    Sommer, W.; Rijnaarts, H.; Grotenhuis, T.; van Gaans, P.

    2012-04-01

    Due to an increasing demand for sustainable energy, application of Aquifer Thermal Energy Storage (ATES) is growing rapidly. Large-scale application of ATES is limited by the space that is available in the subsurface. Especially in urban areas, suboptimal performance is expected due to thermal interference between individual wells of a single system, or interference with other ATES systems or groundwater abstractions. To avoid thermal interference there are guidelines on well spacing. However, these guidelines, and also design calculations, are based on the assumption of a homogeneous subsurface, while studies report a standard deviation in logpermeability of 1 to 2 for unconsolidated aquifers (Gelhar, 1993). Such heterogeneity may create preferential pathways, reducing ATES performance due to increased advective heat loss or interference between ATES wells. The role of hydraulic heterogeneity of the subsurface related to ATES performance has received little attention in literature. Previous research shows that even small amounts of heterogeneity can result in considerable uncertainty in the distribution of thermal energy in the subsurface and an increased radius of influence (Ferguson, 2007). This is supported by subsurface temperature measurements around ATES wells, which suggest heterogeneity gives rise to preferential pathways and short-circuiting between ATES wells (Bridger and Allen, 2010). Using 3-dimensional stochastic heat transport modeling, we quantified the influence of heterogeneity on the performance of a doublet well energy storage system. The following key parameters are varied to study their influence on thermal recovery and thermal balance: 1) regional flow velocity, 2) distance between wells and 3) characteristics of the heterogeneity. Results show that heterogeneity at the scale of a doublet ATES system introduces an uncertainty up to 18% in expected thermal recovery. The uncertainty increases with decreasing distance between ATES wells. The

  1. Predictive Big Data Analytics: A Study of Parkinson?s Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

    OpenAIRE

    Dinov, Ivo D.; Heavner, Ben; Tang, Ming; Glusman, Gustavo; Chard, Kyle; Darcy, Mike; Madduri, Ravi; Pa, Judy; Spino, Cathie; Kesselman, Carl; Foster, Ian; Deutsch, Eric W.; Price, Nathan D.; Van Horn, John D.; Ames, Joseph

    2016-01-01

    Background A unique archive of Big Data on Parkinson?s Disease is collected, managed and disseminated by the Parkinson?s Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationsh...

  2. Neutronic of heterogenous gas cooled reactors

    International Nuclear Information System (INIS)

    Maturana, Roberto Hernan

    2008-01-01

    At present, one of the main technical features of the advanced gas cooled reactor under development is its fuel element concept, which implies a neutronic homogeneous design, thus requiring higher enrichment compared with present commercial nuclear power plants.In this work a neutronic heterogeneous gas cooled reactor design is analyzed by studying the neutronic design of the Advanced Gas cooled Reactor (AGR), a low enrichment, gas cooled and graphite moderated nuclear power plant.A search of merit figures (some neutronic parameter, characteristic dimension, or a mixture of both) which are important and have been optimized during the reactor design stage is been done, to aim to comprise how a gas heterogeneous reactor is been design, given that semi-infinity arrangement criteria of rods in LWRs and clusters in HWRs can t be applied for a solid moderator and a gas refrigerator.The WIMS code for neutronic cell calculations is been utilized to model the AGR fuel cell and to calculate neutronic parameters such as the multiplication factor and the pick factor, as function of the fuel burnup.Also calculation is been done for various nucleus characteristic dimensions values (fuel pin radius, fuel channel pitch) and neutronic parameters (such as fuel enrichment), around the design established parameters values.A fuel cycle cost analysis is carried out according to the reactor in study, and the enrichment effect over it is been studied.Finally, a thermal stability analysis is been done, in subcritical condition and at power level, to study this reactor characteristic reactivity coefficients.Present results shows (considering the approximation used) a first set of neutronic design figures of merit consistent with the AGR design. [es

  3. Viscous fingering with permeability heterogeneity

    International Nuclear Information System (INIS)

    Tan, C.; Homsy, G.M.

    1992-01-01

    Viscous fingering in miscible displacements in the presence of permeability heterogeneities is studied using two-dimensional simulations. The heterogeneities are modeled as stationary random functions of space with finite correlation scale. Both the variance and scale of the heterogeneities are varied over modest ranges. It is found that the fingered zone grows linearly in time in a fashion analogous to that found in homogeneous media by Tan and Homsy [Phys. Fluids 31, 1330 (1988)], indicating a close coupling between viscous fingering on the one hand and flow through preferentially more permeable paths on the other. The growth rate of the mixing zone increases monotonically with the variance of the heterogeneity, as expected, but shows a maximum as the correlation scale is varied. The latter is explained as a ''resonance'' between the natural scale of fingers in homogeneous media and the correlation scale

  4. Dynamics of epidemics outbreaks in heterogeneous populations

    Science.gov (United States)

    Brockmann, Dirk; Morales-Gallardo, Alejandro; Geisel, Theo

    2007-03-01

    The dynamics of epidemic outbreaks have been investigated in recent years within two alternative theoretical paradigms. The key parameter of mean field type of models such as the SIR model is the basic reproduction number R0, the average number of secondary infections caused by one infected individual. Recently, scale free network models have received much attention as they account for the high variability in the number of social contacts involved. These models predict an infinite basic reproduction number in some cases. We investigate the impact of heterogeneities of contact rates in a generic model for epidemic outbreaks. We present a system in which both the time periods of being infectious and the time periods between transmissions are Poissonian processes. The heterogeneities are introduced by means of strongly variable contact rates. In contrast to scale free network models we observe a finite basic reproduction number and, counterintuitively a smaller overall epidemic outbreak as compared to the homogeneous system. Our study thus reveals that heterogeneities in contact rates do not necessarily facilitate the spread to infectious disease but may well attenuate it.

  5. In vivo study on influence of the heterogeneity of tissues in the dose distribution in high energy X ray therapy

    International Nuclear Information System (INIS)

    Aldred, M.A.

    1987-01-01

    Several authors investigated the effect of the heterogeneity of tissue in the dose distribution in a radiation-therapy. Practically all of them carried out ''in vitro'' measurements using a solid body immersed in a water phantom, in order to simulate the inhomogeneity, such as bone, air cavity, etc. In the present work, ''in vivo'' measurements were performed utilizing thermoluminescent dosimeters, whose appropriateness and convenience are well known. Eight patients at Instituto de Radioterapia Oswaldo Cruz were selected, that were under irradiation treatments in their pelvic region. The ratio between body entry radiation dose and the corresponding exit dose, when compared to the same ratio for a homogeneous phantom, gives the influence of the heterogeneity of the tissue the radiation crosses. The results found in those eight patients have shown that ''in vivo'' measurements present a ratio about 8% smaller that in homogeneous phantom case. (author) [pt

  6. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor; Contribution a l'etude des incertitudes des parametres neutroniques d'un coeur compact et heterogene: le reacteur d'irradiation Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Di Salvo, J

    2002-07-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  7. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor; Contribution a l'etude des incertitudes des parametres neutroniques d'un coeur compact et heterogene: le reacteur d'irradiation Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Di Salvo, J

    2002-07-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  8. Mathematical modelling of a self-polishing antifouling paint exposed to seawater: A parameter study

    DEFF Research Database (Denmark)

    Kiil, Søren; Pedersen, M. S.; Dam-Johansen, Kim

    2002-01-01

    , and to suggest ways of controlling biocide release rates. A case study with an antifouling paint based on the well-known tributyltin self-polishing copolymer system showed that the rate of paint polishing was influenced, to various degrees, by the following parameters: seawater pH and concentration of Na...

  9. Effect of anapanasati meditation technique through electrophotonic imaging parameters: A pilot study.

    Science.gov (United States)

    Deo, Guru; Itagi R, Kumar; Thaiyar M, Srinivasan; Kuldeep, Kushwah K

    2015-01-01

    Mindfulness along with breathing is a well-established meditation technique. Breathing is an exquisite tool for exploring subtle awareness of mind and life itself. This study aimed at measuring changes in the different parameters of electrophotonic imaging (EPI) in anapanasati meditators. To carry out this study, 51 subjects comprising 32 males and 19 females of age 18 years and above (mean age 45.64 ± 14.43) were recruited voluntarily with informed consent attending Karnataka Dhyana Mahachakra-1 at Pyramid Valley International, Bengaluru, India. The design was a single group pre- post and data collected by EPI device before and after 5 days of intensive meditation. Results show significant changes in EPI parameter integral area with filter (physiological) in both right and left side, which reflects the availability of high functional energy reserve in meditators. The researchers observed similar trends without filter (psycho-physiological) indicating high reserves of energy at psycho-physiological level also. Activation coefficient, another parameter of EPI, reduced showing more relaxed state than earlier, possibly due to parasympathetic dominance. Integral entropy decreased in the case of psycho-physiological parameters left-side without filter, which indicates less disorder after meditation, but these changes were not significant. The study showed a reversed change in integral entropy in the right side without filter; however, the values on both sides with filter increased, which indicates disorder. The study suggests that EPI can be used in the recording functional physiological and psychophysiological status of meditators at a subtle level.

  10. Studying The Effect of Various Parameters on The Characteristics of The Dielectric and Metallic Photonic Crystals

    International Nuclear Information System (INIS)

    Ismail, M.; Badawy, Z.M.; Abdel-Rahman, E.

    2015-01-01

    Transmittance characteristics of two types of photonic crystals have been analysed using the transfer matrix method. The first one is the dielectric photonic crystal (DPC), and the second is the metallic photonic crystal (MPC). The effect of the most parameters on the transmission spectra of the dielectric and metallic photonic crystals has been studied

  11. Sensitivity studies on parameters affecting gas release from an underground rock cavern

    International Nuclear Information System (INIS)

    Schlueter, E.; Pruess, K.

    1990-01-01

    A series of numerical simulation experiments is performed to quantify the effects of the release and migration of non-condensible gas in water-saturated fractured rock formations. The relative importance of multiphase parameters such as relative permeability, capillary pressure, intrinsic permeability, and porosity on system behavior is studied. 10 refs., 28 figs., 5 tabs

  12. Study on the ownership balance and the efficiency of mixed ownership enterprises from the perspective of heterogeneous shareholders.

    Science.gov (United States)

    Yin, Zhujia; Liu, Lijuan; Wang, Haidong; Wen, Fengming

    2018-01-01

    Based on the database data of Chinese industrial enterprises from 2000 to 2007 and the LP method, this paper measures the total factor productivity of enterprises and investigates the effect of different mixed ownership forms on enterprises' efficiency and the effect of heterogeneous ownership balance on the mixed ownership enterprises' efficiency. The state-owned enterprise and mixed ownership enterprise are identified by the enterprise's paid-up capital. The results show that, on the whole, for the mixed ownership enterprise, the higher the diversification degree of the shareholders is, the higher the efficiency becomes, and in different types of industries, the mixed forms of shareholders have different effects on the efficiency of enterprises. The heterogeneous ownership balance and the enterprise efficiency show nonlinear U-type relationships. Both the higher and lower heterogeneous ownership balance degrees will promote the enterprise's efficiency. However, when the ownership balance degree is in the range of [0.2 0.5], the increase in ownership balance will lead to the decline of enterprise efficiency. Therefore, when introducing non-state-owned capital, state-owned enterprises should take full account of their own characteristics by rationally controlling the shareholding ratio of non-state-owned capital and play the positive role of a mixed ownership structure in corporate governance with appropriate ownership balances.

  13. Study of dose calculation and beam parameters optimization with genetic algorithm in IMRT

    International Nuclear Information System (INIS)

    Chen Chaomin; Tang Mutao; Zhou Linghong; Lv Qingwen; Wang Zhuoyu; Chen Guangjie

    2006-01-01

    Objective: To study the construction of dose calculation model and the method of automatic beam parameters selection in IMRT. Methods: The three-dimension convolution dose calculation model of photon was constructed with the methods of Fast Fourier Transform. The objective function based on dose constrain was used to evaluate the fitness of individuals. The beam weights were optimized with genetic algorithm. Results: After 100 iterative analyses, the treatment planning system produced highly conformal and homogeneous dose distributions. Conclusion: the throe-dimension convolution dose calculation model of photon gave more accurate results than the conventional models; genetic algorithm is valid and efficient in IMRT beam parameters optimization. (authors)

  14. Study of EBSD Experiment Parameters Influence on Computation of Polycrystalline Pole Figures and Orientation Distribution Function

    Directory of Open Access Journals (Sweden)

    Antonova Anastasia O.

    2016-01-01

    Full Text Available Mathematical model for a polycrystalline specimen and EBSD experiment is proposed. As the measurement parameters, the scanning step and the threshold disorientation angle are considered. To study the impact of the measurement parameters Pole Figures and Orientation Distribution Function of model specimen and corresponding ones, calculated from model EBSD measurements, are compared. The real EBSD experiment was also performed. The results of the model experiment are correlated with such detected in the real EBSD data. The most significant results are formulated in the given work.

  15. Calculation of fundamental parameters for the dynamical study of TRIGA-3-Salazar reactor (Mixed reactor core)

    International Nuclear Information System (INIS)

    Viais J, J.

    1994-01-01

    Kinetic parameters for dynamic study of two different configurations, 8 and 9, both with standard fuel, 20% enrichment and Flip (Fuel Life Improvement Program with 70% enrichment) fuel, for TRIGA Mark-III reactor from Mexico Nuclear Center, are obtained. A calculation method using both WIMS-D4 and DTF-IV and DAC1 was established, to decide which of those two configurations has the best safety and operational conditions. Validation of this methodology is done by calculate those parameters for a reactor core with new standard fuel. Configuration 9 is recommended to be use. (Author)

  16. Study of geometrical and operational parameters controlling the low frequency microjet atmospheric pressure plasma characteristics

    International Nuclear Information System (INIS)

    Kim, Dan Bee; Rhee, J. K.; Moon, S. Y.; Choe, W.

    2006-01-01

    Controllability of small size atmospheric pressure plasma generated at low frequency in a pin to dielectric plane electrode configuration was studied. It was shown that the plasma characteristics could be controlled by geometrical and operational parameters of the experiment. Under most circumstances, continuous glow discharges were observed, but both the corona and/or the dielectric barrier discharge characteristics were observed depending on the position of the pin electrode. The plasma size and the rotational temperature were also varied by the parameters. The rotational temperature was between 300 and 490 K, being low enough to treat thermally sensitive materials

  17. Heterogeneity of the HIV epidemic in agrarian, trading, and fishing communities in Rakai, Uganda: an observational epidemiological study.

    Science.gov (United States)

    Chang, Larry W; Grabowski, Mary K; Ssekubugu, Robert; Nalugoda, Fred; Kigozi, Godfrey; Nantume, Betty; Lessler, Justin; Moore, Sean M; Quinn, Thomas C; Reynolds, Steven J; Gray, Ronald H; Serwadda, David; Wawer, Maria J

    2016-08-01

    Understanding the extent to which HIV burden differs across communities and the drivers of local disparities is crucial for an effective and targeted HIV response. We assessed community-level variations in HIV prevalence, risk factors, and treatment and prevention service uptake in Rakai, Uganda. The Rakai Community Cohort Study (RCCS) is an open, population-based cohort of people aged 15-49 years in 40 communities. Participants are HIV tested and interviewed to obtain sociodemographic, behavioural, and health information. RCCS data from Aug 10, 2011, to May 30, 2013, were used to classify communities as agrarian (n=27), trading (n=9), or lakeside fishing sites (n=4). We mapped HIV prevalence with Bayesian methods, and characterised variability across and within community classifications. We also assessed differences in HIV risk factors and uptake of antiretroviral therapy and male circumcision between community types. 17 119 individuals were included, 9215 (54%) of whom were female. 9931 participants resided in agrarian, 3318 in trading, and 3870 in fishing communities. Median HIV prevalence was higher in fishing communities (42%, range 38-43) than in trading (17%, 11-21) and agrarian communities (14%, 9-26). Antiretroviral therapy use was significantly lower in both men and women in fishing communities than in trading (age-adjusted prevalence risk ratio in men 0·64, 95% CI 0·44-0·97; women 0·53, 0·42-0·66) and agrarian communities (men 0·55, 0·42-0·72; women 0·65, 0·54-0·79), as was circumcision coverage among men (vs trading 0·48, 0·42-0·55; vs agrarian 0·64, 0·56-0·72). Self-reported risk behaviours were significantly higher in men than in women and in fishing communities than in other community types. Substantial heterogeneity in HIV prevalence, risk factors, and service uptake in Rakai, Uganda, emphasises the need for local surveillance and the design of targeted HIV responses. High HIV burden, risk behaviours, and low use of combination

  18. Modelling foraging movements of diving predators: a theoretical study exploring the effect of heterogeneous landscapes on foraging efficiency

    Directory of Open Access Journals (Sweden)

    Marianna Chimienti

    2014-09-01

    represents a useful starting point to understand the energetic reasons for a range of potential predator responses to spatial heterogeneity and environmental uncertainties in terms of search behaviour and predator–prey interactions. We highlight future directions that integrated empirical and modelling studies should take to improve our ability to predict how diving predators will be impacted by the deployment of manmade structures in the marine environment.

  19. Multi-parameter geometrical scaledown study for energy optimization of MTJ and related spintronics nanodevices

    Science.gov (United States)

    Farhat, I. A. H.; Alpha, C.; Gale, E.; Atia, D. Y.; Stein, A.; Isakovic, A. F.

    The scaledown of magnetic tunnel junctions (MTJ) and related nanoscale spintronics devices poses unique challenges for energy optimization of their performance. We demonstrate the dependence of the switching current on the scaledown variable, while considering the influence of geometric parameters of MTJ, such as the free layer thickness, tfree, lateral size of the MTJ, w, and the anisotropy parameter of the MTJ. At the same time, we point out which values of the saturation magnetization, Ms, and anisotropy field, Hk, can lead to lowering the switching current and overall decrease of the energy needed to operate an MTJ. It is demonstrated that scaledown via decreasing the lateral size of the MTJ, while allowing some other parameters to be unconstrained, can improve energy performance by a measurable factor, shown to be the function of both geometric and physical parameters above. Given the complex interdependencies among both families of parameters, we developed a particle swarm optimization (PSO) algorithm that can simultaneously lower energy of operation and the switching current density. Results we obtained in scaledown study and via PSO optimization are compared to experimental results. Support by Mubadala-SRC 2012-VJ-2335 is acknowledged, as are staff at Cornell-CNF and BNL-CFN.

  20. A magnetic resonance imaging study on the articulatory and acoustic speech parameters of Malay vowels.

    Science.gov (United States)

    Zourmand, Alireza; Mirhassani, Seyed Mostafa; Ting, Hua-Nong; Bux, Shaik Ismail; Ng, Kwan Hoong; Bilgen, Mehmet; Jalaludin, Mohd Amin

    2014-07-25

    The phonetic properties of six Malay vowels are investigated using magnetic resonance imaging (MRI) to visualize the vocal tract in order to obtain dynamic articulatory parameters during speech production. To resolve image blurring due to the tongue movement during the scanning process, a method based on active contour extraction is used to track tongue contours. The proposed method efficiently tracks tongue contours despite the partial blurring of MRI images. Consequently, the articulatory parameters that are effectively measured as tongue movement is observed, and the specific shape of the tongue and its position for all six uttered Malay vowels are determined.Speech rehabilitation procedure demands some kind of visual perceivable prototype of speech articulation. To investigate the validity of the measured articulatory parameters based on acoustic theory of speech production, an acoustic analysis based on the uttered vowels by subjects has been performed. As the acoustic speech and articulatory parameters of uttered speech were examined, a correlation between formant frequencies and articulatory parameters was observed. The experiments reported a positive correlation between the constriction location of the tongue body and the first formant frequency, as well as a negative correlation between the constriction location of the tongue tip and the second formant frequency. The results demonstrate that the proposed method is an effective tool for the dynamic study of speech production.

  1. Impact parameter sensitive study of inner-shell atomic processes in the experimental storage ring

    Science.gov (United States)

    Gumberidze, A.; Kozhuharov, C.; Zhang, R. T.; Trotsenko, S.; Kozhedub, Y. S.; DuBois, R. D.; Beyer, H. F.; Blumenhagen, K.-H.; Brandau, C.; Bräuning-Demian, A.; Chen, W.; Forstner, O.; Gao, B.; Gassner, T.; Grisenti, R. E.; Hagmann, S.; Hillenbrand, P.-M.; Indelicato, P.; Kumar, A.; Lestinsky, M.; Litvinov, Yu. A.; Petridis, N.; Schury, D.; Spillmann, U.; Trageser, C.; Trassinelli, M.; Tu, X.; Stöhlker, Th.

    2017-10-01

    In this work, we present a pilot experiment in the experimental storage ring (ESR) at GSI devoted to impact parameter sensitive studies of inner shell atomic processes for low-energy (heavy-) ion-atom collisions. The experiment was performed with bare and He-like xenon ions (Xe54+, Xe52+) colliding with neutral xenon gas atoms, resulting in a symmetric collision system. This choice of the projectile charge states was made in order to compare the effect of a filled K-shell with the empty one. The projectile and target X-rays have been measured at different observation angles for all impact parameters as well as for the impact parameter range of ∼35-70 fm.

  2. The Influence Study of Ultrasonic honing parameters to workpiece surface temperature

    Directory of Open Access Journals (Sweden)

    Zhang Xiaoqiang

    2016-01-01

    Full Text Available Ultrasonic vibration honing(UVH, a machine technology, has a lot of advantages. Lower grinding temperature is a significant character and is beneficial for both processing and workpiece surface. But the high temperature caused by big honing pressure becomes the main factor to produce workpiece heat damage in grinding zone. In various honing parameter combinations, the showing effect is different. Based on the thermodynamics classical theory, established the heat transfer equation for grinding zone, simplified the model and obtained the two-dimenssion temperature field expression for workpiece, then simulated the temperature changing trend in a variety of conditions. It is shown that themain temp is in a range of 700K to 1200K. In addition, the variation is huge for every parameter. The study provides a theoretical basis for deeply seeking reasonable machining parameter and obtaining better workpiece quality.

  3. An experimental study of symmetric and asymmetric peak-fitting parameters for alpha-particle spectrometry

    International Nuclear Information System (INIS)

    Martin Sanchez, A.; Vera Tome, F.; Caceres Marzal, D.; Bland, C.J.

    1994-01-01

    A pulse-height spectrum of alpha-particle emissions at discrete energies can be fitted by the peak-shape functions generated by combining asymmetric truncated exponential functions with a symmetric Gaussian distribution. These functions have been applied successfully by several workers. A correlation was previously found between the variance of the symmetric Gaussian portion of the fitting function, and the parameter characterising the principal exponential tailing function. The results of a more detailed experimental study are reported, which involve varying the angle and the distance between the source and the detector. This analysis shows that the parameters of the symmetric and asymmetric parts of the fitted functions seem to depend on either the detector or the source. These parameters are influenced by the energy loss suffered by the alpha-particles as well as by the efficiency of charge collection in the solid-state detector. (orig.)

  4. Sensitivity study of steam explosion characteristics to uncertain input parameters using TEXAS-V code

    International Nuclear Information System (INIS)

    Grishchenko, Dmitry; Basso, Simone; Kudinov, Pavel; Bechta, Sevostian

    2014-01-01

    Release of core melt from failed reactor vessel into a pool of water is adopted in several existing designs of light water reactors (LWRs) as an element of severe accident mitigation strategy. Corium melt is expected to fragment, solidify and form a debris bed coolable by natural circulation. However, steam explosion can occur upon melt release threatening containment integrity and potentially leading to large early release of radioactive products to the environment. There are many factors and parameters that could be considered for prediction of the fuel-coolant interaction (FCI) energetics, but it is not clear which of them are the most influential and should be addressed in risk analysis. The goal of this work is to assess importance of different uncertain input parameters used in FCI code TEXAS-V for prediction of the steam explosion energetics. Both aleatory uncertainty in characteristics of melt release scenarios and water pool conditions, and epistemic uncertainty in modeling are considered. Ranges of the uncertain parameters are selected based on the available information about prototypic severe accident conditions in a reference design of a Nordic BWR. Sensitivity analysis with Morris method is implemented using coupled TEXAS-V and DAKOTA codes. In total 12 input parameters were studied and 2 melt release scenarios were considered. Each scenario is based on 60,000 of TEXAS-V runs. Sensitivity study identified the most influential input parameters, and those which have no statistically significant effect on the explosion energetics. Details of approach to robust usage of TEXAS-V input, statistical enveloping of TEXAS-V output and interpretation of the results are discussed in the paper. We also provide probability density function (PDF) of steam explosion impulse estimated using TEXAS-V for reference Nordic BWR. It can be used for assessment of the uncertainty ranges of steam explosion loads for given ranges of input parameters. (author)

  5. EX VIVO STUDY OF QUANTITATIVE ULTRASOUND PARAMETERS IN FATTY RABBIT LIVERS

    Science.gov (United States)

    Ghoshal, Goutam; Lavarello, Roberto J.; Kemmerer, Jeremy P.; Miller, Rita J.; Oelze, Michael L.

    2012-01-01

    Nonalcoholic fatty liver disease (NAFLD) affects more than 30% of Americans, and with increasing problems of obesity in the United States, NAFLD is poised to become an even more serious medical concern. At present, accurate classification of steatosis (fatty liver) represents a significant challenge. In this study, the use of high-frequency (8 to 25 MHz) quantitative ultrasound (QUS) imaging to quantify fatty liver was explored. QUS is an imaging technique that can be used to quantify properties of tissue giving rise to scattered ultrasound. The changes in the ultrasound properties of livers in rabbits undergoing atherogenic diets of varying durations were investigated using QUS. Rabbits were placed on a special fatty diet for 0, 3, or 6 weeks. The fattiness of the livers was quantified by estimating the total lipid content of the livers. Ultrasonic properties, such as speed of sound, attenuation, and backscatter coefficients, were estimated in ex vivo rabbit liver samples from animals that had been on the diet for varying periods. Two QUS parameters were estimated based on the backscatter coefficient: effective scatterer diameter (ESD) and effective acoustic concentration (EAC), using a spherical Gaussian scattering model. Two parameters were estimated based on the backscattered envelope statistics (the k parameter and the μ parameter) according to the homodyned K distribution. The speed of sound decreased from 1574 to 1565 m/s and the attenuation coefficient increased from 0.71 to 1.27 dB/cm/MHz, respectively, with increasing fat content in the liver. The ESD decreased from 31 to 17 μm and the EAC increased from 38 to 63 dB/cm3 with increasing fat content in the liver. A significant increase in the μ parameter from 0.18 to 0.93 scatterers/mm3 was observed with increasing fat content in the liver samples. The results of this study indicate that QUS parameters are sensitive to fat content in the liver. PMID:23062376

  6. Noise disturbance in open-plan study environments : a field study on noise sources, student tasks and room acoustic parameters

    NARCIS (Netherlands)

    Braat-Eggen, P.E.; van Heijst, A.W.M.; Hornikx, M.C.J.; Kohlrausch, A.G.

    2017-01-01

    The aim of this study is to gain more insight in the assessment of noise in open-plan study environments and to reveal correlations between noise disturbance experienced by students and the noise sources they perceive, the tasks they perform and the acoustic parameters of the open-plan study

  7. Sleep Parameters in Short Daily versus Conventional Dialysis: An Actigraphic Study

    Directory of Open Access Journals (Sweden)

    Ludimila D’Avila e Silva Allemand

    2017-01-01

    Full Text Available Previous studies have observed worse sleep quality in patients undergoing conventional dialysis as compared to daily dialysis. Our aim was to compare the sleep parameters of patients undergoing daily or conventional dialysis using an objective measure (actigraphy. This cross-sectional study was performed in three dialysis centers, including a convenience sample (nonprobability sampling of 73 patients (36 patients on daily hemodialysis and 37 patients on conventional hemodialysis. The following parameters were evaluated: nocturnal total sleep time (NTST, expressed in minutes; wake time after sleep onset (WASO, expressed in minutes; number of nighttime awakenings; daytime total sleep time (DTST, expressed in minutes; number of daytime naps; and nighttime percentage of sleep (% sleep. The Mini-Mental State Examination and the Beck Depression Inventory were also administered. The mean age was 53.4  ±  17.0 years. After adjustment of confounding factors using multiple linear regression analysis, no difference in actigraphy parameters was detected between the groups: NTST (p=0.468, WASO (p=0.88, % sleep (p=0.754, awakenings (p=0.648, naps (p=0.414, and DTST (p=0.805. Different from previous studies employing qualitative analysis, the present assessment did not observe an influence of hemodialysis modality on objective sleep parameters in chronic renal patients.

  8. Experimental design for estimating parameters of rate-limited mass transfer: Analysis of stream tracer studies

    Science.gov (United States)

    Wagner, Brian J.; Harvey, Judson W.

    1997-01-01

    Tracer experiments are valuable tools for analyzing the transport characteristics of streams and their interactions with shallow groundwater. The focus of this work is the design of tracer studies in high-gradient stream systems subject to advection, dispersion, groundwater inflow, and exchange between the active channel and zones in surface or subsurface water where flow is stagnant or slow moving. We present a methodology for (1) evaluating and comparing alternative stream tracer experiment designs and (2) identifying those combinations of stream transport properties that pose limitations to parameter estimation and therefore a challenge to tracer test design. The methodology uses the concept of global parameter uncertainty analysis, which couples solute transport simulation with parameter uncertainty analysis in a Monte Carlo framework. Two general conclusions resulted from this work. First, the solute injection and sampling strategy has an important effect on the reliability of transport parameter estimates. We found that constant injection with sampling through concentration rise, plateau, and fall provided considerably more reliable parameter estimates than a pulse injection across the spectrum of transport scenarios likely encountered in high-gradient streams. Second, for a given tracer test design, the uncertainties in mass transfer and storage-zone parameter estimates are strongly dependent on the experimental Damkohler number, DaI, which is a dimensionless combination of the rates of exchange between the stream and storage zones, the stream-water velocity, and the stream reach length of the experiment. Parameter uncertainties are lowest at DaI values on the order of 1.0. When DaI values are much less than 1.0 (owing to high velocity, long exchange timescale, and/or short reach length), parameter uncertainties are high because only a small amount of tracer interacts with storage zones in the reach. For the opposite conditions (DaI ≫ 1.0), solute

  9. A study of optimal parameter setting for aMC@NLO + Pythia8 matched setup

    CERN Document Server

    The ATLAS collaboration

    2015-01-01

    This note presents a study to arrive at the optimum tune of Pythia8 generator's parton shower and multiple parton interaction parameters for aMC@NLO + Pythia8 matched setup. Published distributions from ATLAS Run 1 data at 7 TeV for three different processes, inclusive jet, Z~boson and $t\\bar{t}$ production were studied. Additionally, the effect of using two different parton recoil modes in shower, global and local recoil are also investigated.

  10. PARAMETER REPEATABILITY FOR ECONOMY. A CASE STUDY OF A SIMPLE LINEAR ELECTRICAL DEVICE

    Directory of Open Access Journals (Sweden)

    Antoni Drapella

    2017-06-01

    Full Text Available This paper is the first installment of a projected three-part study devoted to both input and output parameter randomness that electrical circuit designers deal with in their work. Parts of the study will differ in the complexity of schemes considered. This paper aims at presenting the methodology while leaving aside the analysis of complex circuits. Therefore, only voltage dividers have been taken into consideration. Four probability distributions of resistor values have been tried: uniform, Gaussian, Laplace and triangular.

  11. A geometric parameter study of piezoelectric coverage on a rectangular cantilever energy harvester

    International Nuclear Information System (INIS)

    Patel, R; McWilliam, S; Popov, A A

    2011-01-01

    This paper proposes a versatile model for optimizing the performance of a rectangular cantilever beam piezoelectric energy harvester used to convert ambient vibrations into electrical energy. The developed model accounts for geometric changes to the natural frequencies, mode shapes and damping in the structure. This is achieved through the combination of finite element modelling and a distributed parameter electromechanical model, including load resistor and charging capacitor models. The model has the potential for use in investigating the influence of numerous geometric changes on harvester performance, and incorporates a model for accounting for changes in damping as the geometry changes. The model is used to investigate the effects of substrate and piezoelectric layer length, and piezoelectric layer thickness on the performance of a microscale device. Findings from a parameter study indicate the existence of an optimum sample length due to increased mechanical damping for longer beams and improved power output using thicker piezoelectric layers. In practice, harvester design is normally based around a fixed operating frequency for a particular application, and improved performance is often achieved by operating at or near resonance. To achieve unbiased comparisons between different harvester designs, parameter studies are performed by changing multiple parameters simultaneously with the natural frequency held fixed. Performance enhancements were observed using shorter piezoelectric layers as compared to the conventional design, in which the piezoelectric layer and substrate are of equal length

  12. A new approach to study interaction parameters in cyanobiphenyl liquid crystal binary systems

    International Nuclear Information System (INIS)

    Javadian, Soheila; Dalir, Nima; Gilani, Ali Ghanadzadeh; Kakemam, Jamal; Yousefi, Ali

    2015-01-01

    Highlights: • The phase transition of 7CB and 5CB liquid crystals studied using the DSC. • This work includes the determination of the eutectic in the 7CB/5CB mixture. • The excess functions and interaction parameters calculated in the 7CB/5CB mixtures. • The P ∗ randomicity parameter used to describe the phase transitions of C–N and N–I. • A small amount of P ∗ showed a non-random identity of the C–N phase transition. - Abstract: The phase transition of heptylcyanobiphenyl 7CB and pentylcyanobiphenyl 5CB liquid crystals was investigated using the differential scanning calorimetry DSC technique. Then, the phase transition of different compositions of 7CB/5CB binary mixture was studied to determine the eutectic point. The phase diagram of mentioned binary system in 7CB mole fraction of 0.45 at T = 273.45 K is in good agreement with that of predicted from Schroder–van Laar equation. The thermodynamic excess functions and interaction parameters were calculated to describe the phase transition physically using the non-random mixing for the first time. The P ∗ randomicity parameter was used to describe the phase transitions of C–N and N–I in which a small amount of P ∗ shows a non-random identity of C–N phase transition. Contrarily, the P ∗ is greater in N–I phase transition showing a random mixing process

  13. Thermodynamic study of fluid in terms of equation of state containing physical parameters

    International Nuclear Information System (INIS)

    Khasare, S. B.

    2015-01-01

    We introduce a simple condition for one mole fluid by considering the thermodynamics of molecules pointing towards the effective potential for the cluster. Efforts are made to estimate new physical parameter f in liquid state using the equation of state containing only two physical parameters such as the hard sphere diameter and binding energy. The temperature dependence of the structural properties and the thermodynamic behavior of the clusters are studied. Computations based on f predict the variation of numbers of particles at the contact point of the molecular cavity (radial distribution function). From the thermodynamic profile of the fluid, the model results are discussed in terms of the cavity due to the closed surface along with suitable energy. The present calculation is based upon the sample thermodynamic data for n-hexanol, such as the ultrasonic wave, density, volume expansion coefficient, and ratio of specific heat in the liquid state, and it is consistent with the thermodynamic relations containing physical parameters such as size and energy. Since the data is restricted to n-hexanol, we avoid giving the physical meaning of f, which is the key parameter studied in the present work. (paper)

  14. Study of Material Densification of In718 in the Higher Throughput Parameter Regime

    Science.gov (United States)

    Cordner, Samuel

    2016-01-01

    Selective Laser Melting (SLM) is a powder bed fusion additive manufacturing process used increasingly in the aerospace industry to reduce the cost, weight, and fabrication time for complex propulsion components. Previous optimization studies for SLM using the Concept Laser M1 and M2 machines at NASA Marshall Space Flight Center have centered on machine default parameters. The objective of this project is to characterize how heat treatment affects density and porosity from a microscopic point of view. This is performs using higher throughput parameters (a previously unexplored region of the manufacturing operating envelope for this application) on material consolidation. Density blocks were analyzed to explore the relationship between build parameters (laser power, scan speed, and hatch spacing) and material consolidation (assessed in terms of density and porosity). The study also considers the impact of post-processing, specifically hot isostatic pressing and heat treatment, as well as deposition pattern on material consolidation in the higher energy parameter regime. Metallurgical evaluation of specimens will also be presented. This work will contribute to creating a knowledge base (understanding material behavior in all ranges of the AM equipment operating envelope) that is critical to transitioning AM from the custom low rate production sphere it currently occupies to the world of mass high rate production, where parts are fabricated at a rapid rate with confidence that they will meet or exceed all stringent functional requirements for spaceflight hardware. These studies will also provide important data on the sensitivity of material consolidation to process parameters that will inform the design and development of future flight articles using SLM.

  15. Noise disturbance in open-plan study environments: a field study on noise sources, student tasks and room acoustic parameters.

    Science.gov (United States)

    Braat-Eggen, P Ella; van Heijst, Anne; Hornikx, Maarten; Kohlrausch, Armin

    2017-09-01

    The aim of this study is to gain more insight in the assessment of noise in open-plan study environments and to reveal correlations between noise disturbance experienced by students and the noise sources they perceive, the tasks they perform and the acoustic parameters of the open-plan study environment they work in. Data were collected in five open-plan study environments at universities in the Netherlands. A questionnaire was used to investigate student tasks, perceived sound sources and their perceived disturbance, and sound measurements were performed to determine the room acoustic parameters. This study shows that 38% of the surveyed students are disturbed by background noise in an open-plan study environment. Students are mostly disturbed by speech when performing complex cognitive tasks like studying for an exam, reading and writing. Significant but weak correlations were found between the room acoustic parameters and noise disturbance of students. Practitioner Summary: A field study was conducted to gain more insight in the assessment of noise in open-plan study environments at universities in the Netherlands. More than one third of the students was disturbed by noise. An interaction effect was found for task type, source type and room acoustic parameters.

  16. Imaging of fast chlorophyll fluorescence induction curve (OJIP) parameters, applied in a screening study with wild barley (Hordeum spontaneum) genotypes under heat stress.

    Science.gov (United States)

    Jedmowski, Christoph; Brüggemann, Wolfgang

    2015-10-01

    We quantified the influence of heat stress (HS) on PSII by imaging of parameters of the fast chlorophyll fluorescence (CF) induction (OJIP) kinetic of 20 genotypes of wild barley (Hordeum spontaneum) covering a broad geographical spectrum. We developed a standardised screening procedure, allowing a repetitive fluorescence measurement of leaf segments. The impact of HS was quantified by calculating a Heat Resistance Index (HRI), derived from the decrease of the Performance Index (PI) caused by HS treatment and following recovery. For the genotype showing the lowest HRI, reduced maximum quantum yield (φP0) and increased relative variable fluorescence of the O-J phase (K-Peak) were detected after HS, whereas the basal fluorescence (F0) remained stable. An additional feature was a lowered fraction of active (QA-reducing) reaction centres (RCs). The disturbances disappeared after one day of recovery. Spatial heterogeneities of fluorescence parameters were detected, as the negative effect of HS was stronger in the leaf areas close to the leaf tip. The results of this study prove that chlorophyll fluorescence imaging (CFI) is suitable for the detection of HS symptoms and that imaging of JIP-Test parameters should be considered in future screening and phenotyping studies aiming for the characterisation of plant genotypes. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. A granular t abu search algorithm for a real case study of a vehicle routing problem with a heterogeneous fleet and time windows

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Jose; Escobar, John Willmer; Linfati, Rodrigo

    2017-07-01

    We consider a real case study of a vehicle routing problem with a heterogeneous fleet and time windows (HFVRPTW) for a franchise company bottling Coca-Cola products in Colombia. This study aims to determine the routes to be performed to fulfill the demand of the customers by using a heterogeneous fleet and considering soft time windows. The objective is to minimize the distance traveled by the performed routes. Design/methodology/approach: We propose a two-phase heuristic algorithm. In the proposed approach, after an initial phase (first phase), a granular tabu search is applied during the improvement phase (second phase). Two additional procedures are considered to help that the algorithm could escape from local optimum, given that during a given number of iterations there has been no improvement. Findings: Computational experiments on real instances show that the proposed algorithm is able to obtain high-quality solutions within a short computing time compared to the results found by the software that the company currently uses to plan the daily routes. Originality/value: We propose a novel metaheuristic algorithm for solving a real routing problem by considering heterogeneous fleet and time windows. The efficiency of the proposed approach has been tested on real instances, and the computational experiments shown its applicability and performance for solving NP-Hard Problems related with routing problems with similar characteristics. The proposed algorithm was able to improve some of the current solutions applied by the company by reducing the route length and the number of vehicles.

  18. A granular t abu search algorithm for a real case study of a vehicle routing problem with a heterogeneous fleet and time windows

    International Nuclear Information System (INIS)

    Bernal, Jose; Escobar, John Willmer; Linfati, Rodrigo

    2017-01-01

    We consider a real case study of a vehicle routing problem with a heterogeneous fleet and time windows (HFVRPTW) for a franchise company bottling Coca-Cola products in Colombia. This study aims to determine the routes to be performed to fulfill the demand of the customers by using a heterogeneous fleet and considering soft time windows. The objective is to minimize the distance traveled by the performed routes. Design/methodology/approach: We propose a two-phase heuristic algorithm. In the proposed approach, after an initial phase (first phase), a granular tabu search is applied during the improvement phase (second phase). Two additional procedures are considered to help that the algorithm could escape from local optimum, given that during a given number of iterations there has been no improvement. Findings: Computational experiments on real instances show that the proposed algorithm is able to obtain high-quality solutions within a short computing time compared to the results found by the software that the company currently uses to plan the daily routes. Originality/value: We propose a novel metaheuristic algorithm for solving a real routing problem by considering heterogeneous fleet and time windows. The efficiency of the proposed approach has been tested on real instances, and the computational experiments shown its applicability and performance for solving NP-Hard Problems related with routing problems with similar characteristics. The proposed algorithm was able to improve some of the current solutions applied by the company by reducing the route length and the number of vehicles.

  19. A Study on Stability of Limit Cycle Walking Model with Feet: Parameter Study

    Directory of Open Access Journals (Sweden)

    Yonggwon Jeon

    2013-01-01

    Full Text Available In this paper, two kinds of feet, namely, curved and flat feet, are added to limit cycle walking model to investigate its stability properties. Although both models are already proposed and are investigated, most previous works are focused on efficiency and gait behaviors. Only the stability properties of the simplest walking model conceived Garcia et al. are well defined. Therefore, there is still a need for a precise research on the effect of feet, especially in the view of local stability, bifurcation route to chaos, global stability, falling boundary and energy balance line. Therefore, this article revisits the stability analysis of limit cycle walking model with various foot shape. To analyze the effects of feet, we re-derive the equation of motion of modified models by adding one more parameter of foot shape than the simplest walking model. Also, the falling boundary and energy balance line of modified models are derived to get proper initial conditions for stable walking and to explain global stability. Simulation results show us that the curved feet can enlarge both stable walking range and area of basin of attraction while the case of flat feet depends on foot shape parameter.

  20. Reproducibility of tumor uptake heterogeneity characterization through textural feature analysis in 18F-FDG PET.

    Science.gov (United States)

    Tixier, Florent; Hatt, Mathieu; Le Rest, Catherine Cheze; Le Pogam, Adrien; Corcos, Laurent; Visvikis, Dimitris

    2012-05-01

    (18)F-FDG PET measurement of standardized uptake value (SUV) is increasingly used for monitoring therapy response and predicting outcome. Alternative parameters computed through textural analysis were recently proposed to quantify the heterogeneity of tracer uptake by tumors as a significant predictor of response. The primary objective of this study was to evaluate the reproducibility of these heterogeneity measurements. Double baseline (18)F-FDG PET scans were acquired within 4 d of each other for 16 patients before any treatment was considered. A Bland-Altman analysis was performed on 8 parameters based on histogram measurements and 17 parameters based on textural heterogeneity features after discretization with values between 8 and 128. The reproducibility of maximum and mean SUV was similar to that in previously reported studies, with a mean percentage difference of 4.7% ± 19.5% and 5.5% ± 21.2%, respectively. By comparison, better reproducibility was measured for some textural features describing local heterogeneity of tracer uptake, such as entropy and homogeneity, with a mean percentage difference of -2% ± 5.4% and 1.8% ± 11.5%, respectively. Several regional heterogeneity parameters such as variability in the intensity and size of regions of homogeneous activity distribution had reproducibility similar to that of SUV measurements, with 95% confidence intervals of -22.5% to 3.1% and -1.1% to 23.5%, respectively. These parameters were largely insensitive to the discretization range. Several parameters derived from textural analysis describing heterogeneity of tracer uptake by tumors on local and regional scales had reproducibility similar to or better than that of simple SUV measurements. These reproducibility results suggest that these (18)F-FDG PET-derived parameters, which have already been shown to have predictive and prognostic value in certain cancer models, may be used to monitor therapy response and predict patient outcome.

  1. Dynamic contact angle cycling homogenizes heterogeneous surfaces.

    Science.gov (United States)

    Belibel, R; Barbaud, C; Mora, L

    2016-12-01

    In order to reduce restenosis, the necessity to develop the appropriate coating material of metallic stent is a challenge for biomedicine and scientific research over the past decade. Therefore, biodegradable copolymers of poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) were prepared in order to develop a new coating exhibiting different custom groups in its side chain and being able to carry a drug. This material will be in direct contact with cells and blood. It consists of carboxylic acid and hexylic groups used for hydrophilic and hydrophobic character, respectively. The study of this material wettability and dynamic surface properties is of importance due to the influence of the chemistry and the potential motility of these chemical groups on cell adhesion and polymer kinetic hydrolysis. Cassie theory was used for the theoretical correction of contact angles of these chemical heterogeneous surfaces coatings. Dynamic Surface Analysis was used as practical homogenizer of chemical heterogeneous surfaces by cycling during many cycles in water. In this work, we confirmed that, unlike receding contact angle, advancing contact angle is influenced by the difference of only 10% of acidic groups (%A) in side-chain of polymers. It linearly decreases with increasing acidity percentage. Hysteresis (H) is also a sensitive parameter which is discussed in this paper. Finally, we conclude that cycling provides real information, thus avoiding theoretical Cassie correction. H(10)is the most sensible parameter to %A. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. ¹⁸F-FDG PET metabolic parameters and MRI perfusion and diffusion parameters in hepatocellular carcinoma: a preliminary study.

    Directory of Open Access Journals (Sweden)

    Sung Jun Ahn

    Full Text Available OBJECTIVES: Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC, using multimodality imaging such as ¹⁸F-FDG positron emission tomography (PET, dynamic contrast enhanced (DCE-MRI, and diffusion weighted imaging(DWI. MATERIALS AND METHODS: Twenty-one patients with advanced HCC underwent ¹⁸F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV(max from ¹⁸F-FDG-PET, variables of the volume transfer constant (K(trans from DCE-MRI and apparent diffusion coefficient (ADC from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV(max and variables of K(trans and ADC was evaluated by Mann-Whitney test. RESULTS: SUV(max showed significant negative correlation with K(trans(max (ρ = -0.622, p = 0.002. However, variables of ADC showed no relationship with variables of K(trans or SUV(max (p>0.05. Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K(trans (p>0.05. CONCLUSION: In this study, SUV was shown to be correlated with K(trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.

  3. Polyunsaturated fatty acids and calcaneal ultrasound parameters among Inuit women from Nuuk (Greenland): a longitudinal study.

    Science.gov (United States)

    Paunescu, Alexandra-Cristina; Ayotte, Pierre; Dewailly, Eric; Dodin, Sylvie; Pedersen, Henning S; Mulvad, Gert; Côté, Suzanne

    2013-01-01

    The traditional diet of Inuit people comprises large amounts of fish and marine mammals that are rich in omega-3 polyunsaturated fatty acids (PUFAs). Results from in vitro studies, laboratory animal experiments and population studies suggest that omega-3 PUFA intake and a high omega-3/omega-6 ratio exert a positive effect on bone health. This longitudinal study was conducted to examine the relationship between omega-3 and omega-6 PUFA status and quantitative ultrasound (QUS) parameters in Greenlandic Inuit women. The study included 118 Inuit women from Nuuk (Greenland), aged 49-64 years, whose QUS parameters measured at baseline (year 2000), along with PUFA status and covariates, and follow-up QUS measurements 2 years later (year 2002). QUS parameters [speed of sound (SOS); broadband ultrasound attenuation (BUA)] were measured at the right calcaneus with a water-bath Lunar Achilles instrument. Omega-3 and omega-6 PUFA contents of erythrocyte membrane phospholipids were measured after transmethylation by gas chromatography coupled with a flame ionization detector. Relationships between QUS parameters and different PUFAs were studied in multiple linear regression models. Increasing values of EPA, DHA and the omega-3/omega-6 PUFA ratio were associated with increased BUA values measured at follow-up (year 2002). These associations were still present in models adjusted for several confounders and covariates. We found little evidence of associations between PUFAs and SOS values. The omega-3 PUFA intake from marine food consumption seems to have a positive effect on bone intrinsic quality and strength, as revealed by higher BUA values in this group of Greenlandic Inuit women.

  4. Study of Material Consolidation at Higher Throughput Parameters in Selective Laser Melting of Inconel 718

    Science.gov (United States)

    Prater, Tracie

    2016-01-01

    Selective Laser Melting (SLM) is a powder bed fusion additive manufacturing process used increasingly in the aerospace industry to reduce the cost, weight, and fabrication time for complex propulsion components. SLM stands poised to revolutionize propulsion manufacturing, but there are a number of technical questions that must be addressed in order to achieve rapid, efficient fabrication and ensure adequate performance of parts manufactured using this process in safety-critical flight applications. Previous optimization studies for SLM using the Concept Laser M1 and M2 machines at NASA Marshall Space Flight Center have centered on machine default parameters. The objective of this work is to characterize the impact of higher throughput parameters (a previously unexplored region of the manufacturing operating envelope for this application) on material consolidation. In phase I of this work, density blocks were analyzed to explore the relationship between build parameters (laser power, scan speed, hatch spacing, and layer thickness) and material consolidation (assessed in terms of as-built density and porosity). Phase II additionally considers the impact of post-processing, specifically hot isostatic pressing and heat treatment, as well as deposition pattern on material consolidation in the same higher energy parameter regime considered in the phase I work. Density and microstructure represent the "first-gate" metrics for determining the adequacy of the SLM process in this parameter range and, as a critical initial indicator of material quality, will factor into a follow-on DOE that assesses the impact of these parameters on mechanical properties. This work will contribute to creating a knowledge base (understanding material behavior in all ranges of the AM equipment operating envelope) that is critical to transitioning AM from the custom low rate production sphere it currently occupies to the world of mass high rate production, where parts are fabricated at a rapid

  5. Experimental study on characteristics of interfacial parameter distribution for upward bubbly flow in inclined tube

    International Nuclear Information System (INIS)

    Xing Dianchuan; Yan Changqi; Sun Licheng; Liu Jingyu

    2013-01-01

    Experimental study on characteristics of interfacial parameter distribution for air-water bubbly flow in an inclined circular tube was performed by using the double sensor probe method. Parameters including radial distributions of local void fraction, bubble passing frequency, interfacial area concentration and bubble equivalent diameter were measured using the probe. The inner diameter of test section is 50 mm, and the liquid superficial velocity is 0.144 m/s, with the gas superficial velocity ranging from 0 to 0.054 m/is. The results show that bubbles obviously move toward the upper wall and congregate. The local interfacial area concentration, bubble passing frequency and void fraction have similar radial distribution profiles. Different from the vertical condition, for a cross-sectional area of the test section, the peak value near the upper side increases, while decreases or even disappears near the underside. The local parameter increases as the radial positions change from lower to upper location, and the increased slope becomes larger as the inclination angles increase. The equivalent bubble diameter doesn't vary with radial position, superficial gas velocity and inclination angle, and bubble aggregation and breaking up nearly doesn't occur. The mechanism of effects of inclination on local parameter distribution for bubbly flow is explained by analyzing the transverse force governing the bubble motion. (authors)

  6. Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study.

    Science.gov (United States)

    Campo, R; Binda, M M; Van Kerkhoven, G; Frederickx, V; Serneels, A; Roziers, P; Lopes, A S; Gordts, S; Puttemans, P; Gordts, S

    2010-01-01

    Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Over a four-month period, all patients at the Leuven Institute of Fertility and Embryology (LIFE) were -randomly allocated to have their embryos cultured in either the standard sequential culture medium ISM1 (control) or in a new universal medium (GM501) (study group). Primary outcome parameters were clinical pregnancy and live birth rate. The secondary outcome parameter was the correlation of embryo fragmentation rate with pregnancy outcome. We did not observe any differences between the ISM1 control group and GM501 study group with regard to fertilization, pregnancy, implantation rates, ongoing pregnancy, and babies born. The number of embryos with a minimal fragmentation rate (less than 30%) was significantly higher in the GM501 study group. Although a significant higher embryo fragmentation rate was seen in In vitro culture of embryos in GM501, pregnancy outcome results were comparable to those of embryos cultured in ISM1. According to our results the value of embryo morphological criteria as a parameter for pregnancy outcome should be examined and discussed again.

  7. Effect of heterogeneities on evaluating earthquake triggering of volcanic eruptions

    Directory of Open Access Journals (Sweden)

    J. Takekawa

    2013-02-01

    Full Text Available Recent researches have indicated coupling between volcanic eruptions and earthquakes. Some of them calculated static stress transfer in subsurface indu