WorldWideScience

Sample records for par champs tangentiels

  1. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

  2. Automatic device for compensating the earths, magnetic field around a {beta} spectrometer; Ensemble automatique de compensation du champ terrestre autour d'un spectrometre

    Energy Technology Data Exchange (ETDEWEB)

    Ristori, Ch [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1967-02-15

    This paper shows how the earth magnetic field inside a double focusing, {pi}{radical}2, iron free, beta ray spectrometer (radius 50 cm ) has been compensated. Three orthogonal magnetic fields are generated by three square coils sets. Each stabilized power supply is regulated through its own magnetometer (of the fluxgate type) and the earth field inside the spectrometer is compensated to 10{sup -4} Oe whatever the earth field or power supply oscillation could be. (author) [French] Cette etude a pour but de compenser le champ magnetique terrestre autour d'un spectrometre beta {pi}{radical}2 a double focalisation, a bobines sans fer et de rayon moyen des trajectoires de 50 cm. Le champ magnetique terrestre est compense par superposition de trois champs orthogonaux, chacun cree par un ensemble de cadres carres. Chacune de ces composantes est mesuree par un magnetometre. Cet ensemble permet de travailler en regulation de courant ou en regulation de champ. En regulation de courant, l'operation est manuelle. En regulation de champ, pour chaque groupe de cadres, l'alimentation stabilisee est asservie par son magnetometre et malgre les variations du champ terrestre ou de la tension secteur, la compensation du champ terrestre se fait toujours correctement au niveau du spectrometre, a 10{sup -4} Oe pres. (auteur)

  3. Differential measurement of the earth's magnetic field by nuclear magnetic resonance; Mesure differentielle du champ magnetique terrestre par resonance magnetique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Robach, F [Commissariat a l' Energie Atomique, 38 - Grenoble (France). Centre d' Etudes Nucleaires

    1967-07-01

    MNR transducers using proton dynamic polarisation allows to convert into a phase measurement any variation of the earth magnetic field. There exist several versions of the instrument corresponding to various models of MNR transducers, which the author analyses in detail, devoting an important place to influence of their alignment with respect to the earth's magnetic field. The sensibility obtained is of one hundredth of a gamma over a bandwidth of (0-0,1 Hz). - This instrument is designed for measuring field gradients in airborne magnetic surveying, for detecting nearly magnetic anomalies, and for distinguishing between nearly and distant magnetic phenomena. (author) [French] L'emploi de capteurs, bases sur la resonance magnetique nucleaire des protons en presence de polarisation dynamique, permet de traduire une difference de champ magnetique terrestre en une mesure de phase. L'appareil existe sous plusieurs versions avec des capteurs de modeles differents dont l'auteur fait une analyse detaillee en accordant une part importante a l'influence de l'orientation des capteurs par rapport au champ magnetique terrestre. La sensibilite est de 1/100 {gamma} pour une bande passante de (0 - 0,1 Hz). Cet appareil s'applique a la mesure du gradient en prospection magnetique aeroportee, a la detection d'anomalies magnetiques proches, a la differentiation d'effets magnetiques proches et lointains. (auteur)

  4. Nouvelles approches en theorie du champ moyen dynamique: le cas du pouvoir thermoelectrique et celui de l'effet orbital d'un champ magnetique

    Science.gov (United States)

    Arsenault, Louis-Francois

    Les applications reliees a la generation d'energie motivent la recherche de materiaux ayant un fort pouvoir thermoelectrique (S). De plus, S nous renseigne sur certaines proprietes fondamentales des materiaux, comme, par exemple, la transition entre l'etat coherent et incoherent des quasi-particules lorsque la temperature augmente. Empiriquement, la presence de fortes interactions electron-electron peut mener a un pouvoir thermoelectrique geant. Nous avons donc etudie le modele le plus simple qui tient compte de ces fortes interactions, le modele de Hubbard. La theorie du champ moyen dynamique (DMFT) est tout indiquee dans ce cas. Nous nous sommes concentres sur un systeme tridimensionnel (3d) cubique a face centree (fcc), et ce, pour plusieurs raisons. A) Ce type de cristal est tres commun dans la nature. B) La DMFT donne de tres bons resultats en 3d et donc ce choix sert aussi de preuve de principe de la methode. C) Finalement, a cause de la frustration electronique intrinseque au fcc, celui-ci ne presente pas de symetrie particule-trou, ce qui est tres favorable a l'apparition d'une grande valeur de S. Ce travail demontre que lorsque le materiau est un isolant a demi-remplissage a cause des fortes interactions (isolant de Mott), il est possible d'obtenir de grands pouvoirs thermoelectriques en le dopant legerement. C'est un resultat pratique important. Du point de vue methodologique, nous avons montre comment la limite de frequence infinie de S et l'approche dite de Kelvin, qui considere la limite de frequence nulle avant la limite thermodynamique pour S, donnent des estimations fiables de la vraie limite continue (DC) dans les domaines de temperature appropriee. Ces deux approches facilitent grandement les calculs en court-circuit ant la necessite de recourir a de problematiques prolongements analytiques. Nous avons trouve que la methode de calcul a frequence infinie fonctionne bien lorsque les echelles d'energie sont relativement faibles. En d'autres termes

  5. Notes on the measurement of stress by resistance gauges in the presence of a magnetic field; Note sur les mesures de contraintes par jauges a fil resistant en presence de champ magnetique

    Energy Technology Data Exchange (ETDEWEB)

    Armand, G; Lapujoulade, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    The technique of stress measurement by resistance gauges is well known. Although it is not yet perfect it possesses many advantages and shows great possibilities. In the presence of a magnetic field the measurement is perturbed by certain phenomena, and we have undertaken to calculate their order of magnitude with a view to establishing the error involved in the measurement. Our problem was to measure the stresses on the various parts of the magnet in the synchrotron Saturne. It is known that the induction passes from a value of about nil to 15000 gauss in 0.8 second, and returns to zero in the same time interval; this cycle recurs every 3.2 seconds. In order to isolate the effects the problem of measurements in a static field will be examined first, after which the results obtained will be extended to the case of dynamic fields. (author) [French] La technique de mesure de contraintes par jauges a fil resistant est bien connue. Elle presente de nombreux avantages, beaucoup de possibilites, bien que n'etant pas encore parfaite. En presence de champ magnetique, la mesure est perturbee par un certain nombre de phenomenes dont nous avons ete conduits a chiffrer l'ordre de grandeur afin de connaitre l'erreur commise lors de la mesure. Precisons qu'il s'agissait pour nous de mesurer les contraintes sur les differents organes de l'aimant du synchrotron Saturne. L'on sait que la valeur de l'induction au droit de l'entrefer passe d'une valeur sensiblement nulle a 15000 gauss en 0,8 secondes, pour revenir ensuite a zero pendant un temps egal au precedent; le cycle ci-dessus se reproduit toutes les 3,2 secondes. Afin de separer les effets, nous examinerons d'abord le probleme des mesures en champ statique puis nous etendrons les resultats obtenus au cas des champs dynamiques. (auteur)

  6. Improvement of the heat exchanges by application of an electric field in the boiling freon 12; Amelioration des echanges thermiques par application d'un champ electrique dans le freon 12 bouillant

    Energy Technology Data Exchange (ETDEWEB)

    Bonjour, Emmanuel; Verdier, Jacques; Weil, Louis [Commissariat a l' energie atomique et aux energies alternatives - CEA, Centre d' Etudes Nucleaires de Grenoble (France)

    1960-07-01

    lt was already known that the heat exchanges by simple convection are considerably improved by the application of an electric field, but no study about the effect of this field when there is ebullition has been issued until now. The authors indicate the result of their experimental investigations which present a very great interest for the increase of the efficiency of the refrigeration cycles. Reprint of a paper published in Revue generale du froid, Sep 1960 [French] On savait deja qu'il etait possible d'ameliorer sensiblement les echanges thermiques dus a la simple convection par l'application d'un champ electrique, mais jusqu'a present, il n'existait pas de resultats concernant l'effet de ce champ en presence d'ebullition. Les auteurs indiquent les resultats de leur investigation experimentale qui presente un tres grand interet pour l'accroissement de l'efficacite du cycle de refrigeration. Reproduction d'un article publie dans Revue generale du froid, Sep 1960.

  7. Motion of a particle in a radial space-charge field and in an axial magnetic field; Le mouvement d'une particule dans un champ de charge d'espace radial et un champ magnetique axial

    Energy Technology Data Exchange (ETDEWEB)

    Canobbio, E [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Services de Physique Appliquee, Service d' Ionique Generale, Section d' Etudes des Interactions Ondes Plasmas; Finzi, U [Institut de Physique Theorique de Milan (Italy)

    1966-07-01

    The motion of a charged particle in an axial uniform steady magnetic field, under the action of a radial space charge is calculated. A cylindrical symmetric charge distribution similar to the one which is observed in HF plasma accelerators is assumed. The particle motion is discussed with the method of effective potentials. A radial acceleration of ions is shown to be possible if the space charge density is sufficiently high. The displacement of the turning points of the trajectories due to the electrostatic field is calculated in the low plasma density approximation. Finally a HF circularly polarized electric field is introduced, the shift in cyclotron resonance is calculated and a low frequency resonance is found to be possible. (authors) [French] On etudie le mouvement d'une particule dans un champ magnetique axial uniforme et constant en presence d'un champ de charge d'espace radial. On considere une distribution de charge a symetrie cylindrique, semblable a celle qu'on observe dans les accelerateurs de plasma a H.F. On se sert des potentiels effectifs pour discuter les caracteristiques du mouvement. Une acceleration radiale des ions est possible lorsque la densite de charge est assez elevee. On calcule aussi les deplacements des points de rebroussement des trajectoires produits par un champ electrostatique faible. On introduit enfin un champ electrique HF polarise circulairement et on calcule le deplacement de la resonance de cyclotron du au champ de charge d'espace. En meme temps on voit apparaitre dans l'energie cinetique de la particule une resonance a basse frequence. (auteurs)

  8. Application du groupe de renormalisation aux conducteurs organiques quasi-unidimensionnels soumis a un champ magnetique

    Science.gov (United States)

    Hubert, Laurent

    Des conducteurs organiques fortement anisotropes presentent, sous l'effet d'un champ magnetique, une etonnante variete de proprietes physiques tel que: l'effet Shubnikov-de Haas, l'effet de Haas-van-Alphen, l'existence de cascades d'ondes de densite de spin apparentees a l'effet Hall quantique, reentrance vers la phase metallique pouvant provenir d'un 'breakdown' magnetique, et tout recemment la possibilite d'un confinement charge induit par le champ magnetique. A cela s'ajoute les nombreuses caracteristiques deja apparues en variant la pression hydrostatique ou la substitution chimique: separation spin-charge, localisation de la charge, transition spin-Peierls, antiferromagnetisme itinerant ou non, supraconductivite, et l'existence d'une frontiere commune entre les phases supraconductrice et antiferromagnetique. En vue de completer la description theorique du diagramme de phase generalise des conducteurs organiques, nous adaptons et elargissons la methode du groupe de renormalisation quantique (GRQ) au cas ou le champ magnetique est non nul. On sait deja que cette methode permet de resoudre le dilemme tout particulier des composes Q-1D, soit leur capacite de produire des transitions de phase malgre leur forte anisotropie et consequemment de leur faible dimensionalite. Cette methode est deja utilisee pour decrire le diagramme de phase temperature versus pression des sels de Bechgaard, de leurs analogues souffres et mixtes. Le GRQ permet aussi de comprendre comment des systemes anisotropes comme les conducteurs organiques peuvent se comporter comme des liquides de Luttinger a haute temperature et comme des liquides de Fermi ou condenses a basse temperature. Nous montrons que l'introduction d'un champ magnetique dans un regime de saut coherent interchai ne a deux particules n'apporte que de simples corrections aux lois d'echelles dans le canal zero son, alors qu'il introduit un mecanisme de brisure de paire dans le canal Cooper. Dans le regime de saut coherent a une

  9. High speed pulsed magnetic fields measurements, using the Faraday effect; Mesures de champs magnetiques pulses rapides a l'aide de l'effet Faraday

    Energy Technology Data Exchange (ETDEWEB)

    Dillet, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-12-01

    For these measures, the information used is the light polarization plane rotation induced by the magnetic field in a glass probe. This rotation is detected using a polarizer-analyzer couple. The detector is a photomultiplier used with high-current and pulsed light. In a distributed magnet (gap: 6 x 3 x 3 cm) magnetic fields to measure are 300 gauss, lasting 0.1 {mu}s, with rise times {<=} 35 ns, repetition rate: 1/s. An oscilloscope is used to view the magnetic field from the P.M. plate signal. The value of the field is computed from a previous static calibration. Magnetic fields from 50 to 2000 gauss (with the probe now used) can be measured to about 20 gauss {+-} 5 per cent, with a frequency range of 30 MHz. (author) [French] Pour faire de telles mesures, on utilise comme information la rotation du plan de polarisation de la lumiere provoquee par le champ magnetique dans une sonde en verre. On detecte cette rotation au moyen d'un polariseur et d'un analyseur, qui sont regles a 45 deg. pour conserver un phenomene lineaire. Le detecteur est un photomultiplicateur travaillant en fort courant en lumiere pulsee. Dans un aimant distribue d'entrefer 6 x 3 x 3 cm, on obtient des champs magnetiques a mesurer de 300 gauss, durant 0.1 {mu}s, avec des temps de montee {<=} 35 ns; au taux de 1 fois par seconde. L'observation du champ se fait sur oscilloscope a partir du signal de plaque du P.M. La valeur absolue du champ est obtenue au moyen d'un etalonnage statique prealable. On peut ainsi mesurer a 20 gauss et {+-} 5 pour cent pres environ des champs magnetiques de 50 a 2000 gauss (avec la sonde actuelle) et avec une bande passante de 30 MHz. (auteur)

  10. Influence of extranuclear fields on angular correlations; Influence des champs extranucleaires sur les correlations angulaires

    Energy Technology Data Exchange (ETDEWEB)

    Abragam, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    A general formalism is given for the description of the perturbation of angular correlations by extranuclear fields. An application is made to the case of static interactions in solids and time dependent interactions in liquids. (author) [French] On donne un formalisme general pour la description de la perturbation des correlations angulaires par des champs extranucleaires. Ce formalisme est applique aux cas des interactions statiques dans les solides et des interactions dependantes du temps dans les liquides. (auteur)

  11. Vecteurs Singuliers des Theories des Champs Conformes Minimales

    Science.gov (United States)

    Benoit, Louis

    En 1984 Belavin, Polyakov et Zamolodchikov revolutionnent la theorie des champs en explicitant une nouvelle gamme de theories, les theories quantiques des champs bidimensionnelles invariantes sous les transformations conformes. L'algebre des transformations conformes de l'espace-temps presente une caracteristique remarquable: en deux dimensions elle possede un nombre infini de generateurs. Cette propriete impose de telles conditions aux fonctions de correlations qu'il est possible de les evaluer sans aucune approximation. Les champs des theories conformes appartiennent a des representations de plus haut poids de l'algebre de Virasoro, une extension centrale de l'algebre conforme du plan. Ces representations sont etiquetees par h, le poids conforme de leur vecteur de plus haut poids, et par la charge centrale c, le facteur de l'extension centrale, commune a toutes les representations d'une meme theorie. Les theories conformes minimales sont constituees d'un nombre fini de representations. Parmi celles-ci se trouvent des theories unitaires dont les representation forment la serie discrete de l'algebre de Virasoro; leur poids h a la forme h_{p,q}(m)=[ (p(m+1) -qm)^2-1] (4m(m+1)), ou p,q et m sont des entiers positifs et p+q= 2. Ces representations possedent un sous-espace invariant engendre par deux sous-representations avec h_1=h_{p,q} + pq et h_2=h_{p,q} + (m-p)(m+1-q) dont chacun des vecteurs de plus haut poids portent le nom de vecteur singulier et sont notes respectivement |Psi _{p,q}> et |Psi_{m-p,m+1-q}>. . Les theories super-conformes sont une version super-symetrique des theories conformes. Leurs champs appartiennent a des representation de plus haut poids de l'algebre de Neveu-Schwarz, une des deux extensions super -symetriques de l'algebre de Virasoro. Les theories super -conformes minimales possedent la meme structure que les theories conformes minimales. Les representations sont elements de la serie h_{p,q}= [ (p(m+2)-qm)^2-4] /(8m(m+2)) ou p,q et m sont

  12. Perturbation analysis of cyclotron resonance in the electromagnetic field of a TE{sub 011} mode; Analyse par perturbation de la resonance cyclotronique dans le champ electromagnetique en mode TE{sub 011} mode

    Energy Technology Data Exchange (ETDEWEB)

    Dreicer, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    The motion of an electron orbiting under the combined action of a static magnetic field and the AC azimuthal electric field of a cylindrical TE{sub 011} mode is analyzed with help of a perturbation technique. The first and second order perturbation results indicate that at cyclotron resonance the electron's center of gyration oscillates slowly at right angles to the magnetic field between two turning points. We find that superimposed upon this nearly static Exb drift the electron cyclically undergoes the process of cyclotron absorption and induced emission. Our results indicate that it is possible to insure maser action (i.e. induced emission rather than absorption) without special preparation of the electron's velocity provided that the electron is introduced into the field in certain special regions of space pervaded by the TE mode. This is a case where over-population of the upper state is accomplished through 'pumping' in real space. The relation between an electron cyclotron resonance maser based upon this principle and one based upon the principle of velocity space pumping, due to Twiss, is examined. This treatment provides physical interpretations and verifies the numerical results found earlier by Le Gardeur. (author) [French] Le mouvement d'un electron soumis a l'action combinee d'un champ magnetique statique et d'un champ electrique haute frequence azimutal engendre dans une cavite cylindrique en mode TE{sub 011} est analyse a partir d'une methode de perturbation. Les resultats des perturbations au premier et deuxieme ordre indiquent qu'a la resonance cyclotronique, le centre de giration de l'electron oscille lentement dans le plan perpendiculaire au champ magnetique entre deux points de rebroussement. En plus de la derivee quasi-statique ExB, l'electron passe par des etats d'absorption et emission cyclotronique. Les resultats du calcul confirment la possibilite d'avoir une action maser (c'est-a-dire: emission au lieu d'absorption) sans que la vitesse des

  13. First champ mission results for gravity, magnetic and atmospheric studies

    CERN Document Server

    Lühr, Hermann; Schwintzer, Peter

    2003-01-01

    In the summer of 2000 the German geo-research satellite CHAMP was launched into orbit. Its innovative payload arrangement and the low intial orbit allow CHAMP to simultaneously collect and almost continuously analyse precise data relating to gravity and magnetic fields at low altitude. In addition to this CHAMP also measures the neutral atmosphere and ionosphere using GPS techniques. Eighteen months after the launch, CHAMP research groups from all over the world met at the Geo-Forschungs-Zentrum in Potsdam for an initial exchange of experiences and results. The main outcome of this user meeting is summarized in this volume. Apart from technical information about the mission, the book offers a comprehensive insight into the present status of CHAMP data exploitation for Earth system research and practical applications in geodesy, geophysics and meteorology.

  14. An Evaluation of CHAMPS: A Classroom Management Program

    Science.gov (United States)

    Minnear, Holly J.

    2015-01-01

    This dissertation was designed to examine the impact of Conversation, Help, Activity, Movement, Participation, Success (CHAMPS), a classroom management program in elementary schools in a district in North Carolina. The participants included principals and teachers who attended a 2-day training course and implemented the CHAMPS program at their…

  15. Cross-Cultural Adaptation of the CHAMPS Questionnaire in French Canadians with COPD

    Science.gov (United States)

    Mak, Susanne; Soicher, Judith E.; Mayo, Nancy E.; Wood-Dauphinee, Sharon; Bourbeau, Jean

    2016-01-01

    Physical activity is difficult to measure in individuals with COPD. The Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire demonstrated strong clinometric properties when used with the elderly and with those affected by chronic disease. Study objectives were to translate, culturally adapt the CHAMPS into French, and reexamine its test-retest reliability and construct validity in French and English Canadians with COPD. This paper presents the cross-cultural adaptation of the CHAMPS; results of its clinometric testing will be described in another article. The CHAMPS examines the degree of physical activity performed in a typical week through two summary scales, caloric expenditure and activity frequency. The CHAMPS was only in English; thus, a cross-cultural adaptation was needed to translate the CHAMPS into French for use in French Canadians with COPD. Cross-cultural adaptation consisted of forward and back translation, with expert review at each stage of translation: minor inconsistencies were uncovered and rectified. Five French participants with COPD completed the finalized Canadian French CHAMPS and participated in cognitive debriefing; no problematic items were identified. A structured and stepwise, cross-cultural adaptation process produced the Canadian French CHAMPS, with items of equivalent meaning to the English version, for use in French Canadians with COPD. PMID:27445570

  16. Cross-Cultural Adaptation of the CHAMPS Questionnaire in French Canadians with COPD

    Directory of Open Access Journals (Sweden)

    Susanne Mak

    2016-01-01

    Full Text Available Physical activity is difficult to measure in individuals with COPD. The Community Healthy Activities Model Program for Seniors (CHAMPS questionnaire demonstrated strong clinometric properties when used with the elderly and with those affected by chronic disease. Study objectives were to translate, culturally adapt the CHAMPS into French, and reexamine its test-retest reliability and construct validity in French and English Canadians with COPD. This paper presents the cross-cultural adaptation of the CHAMPS; results of its clinometric testing will be described in another article. The CHAMPS examines the degree of physical activity performed in a typical week through two summary scales, caloric expenditure and activity frequency. The CHAMPS was only in English; thus, a cross-cultural adaptation was needed to translate the CHAMPS into French for use in French Canadians with COPD. Cross-cultural adaptation consisted of forward and back translation, with expert review at each stage of translation: minor inconsistencies were uncovered and rectified. Five French participants with COPD completed the finalized Canadian French CHAMPS and participated in cognitive debriefing; no problematic items were identified. A structured and stepwise, cross-cultural adaptation process produced the Canadian French CHAMPS, with items of equivalent meaning to the English version, for use in French Canadians with COPD.

  17. Documentation for delivery of Star Tracker to CHAMP

    DEFF Research Database (Denmark)

    Madsen, Peter Buch; Betto, Maurizio; Jørgensen, John Leif

    1999-01-01

    The documentation EIDP (End Item Data Package) describes all the tests which have been performed on the flight hardware of the Star Tracker for the German satellite CHAMP.......The documentation EIDP (End Item Data Package) describes all the tests which have been performed on the flight hardware of the Star Tracker for the German satellite CHAMP....

  18. The Weiss molecular field and the local molecular field; Le champ moleculaire de Weiss et le champ moleculaire local

    Energy Technology Data Exchange (ETDEWEB)

    Neel, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Faculte des Sciences de Grenoble, 38 (France)

    1959-07-01

    Initially, the present report outlines the work done by P. Weiss in the molecular field and spontaneous magnetization theory. It then stresses the success of the theory in the interpretation of the magnetic and energetic properties of ferro-magnetic bodies, and indicates recent progress: 'the energetic molecular field, and the corrective molecular field of the equation of state'. In the second part, the author reviews the difficulties encountered by the theory, and shows how they were overcome by the introduction of the notion of the 'local molecular field', thus supplying the key to the properties of anti-ferro and ferri-magnetic bodies. The present level of progress in the interpretation of the magnetic properties of pyrrhotite, which played a major part in the molecular field discoveries, is also discussed in paragraph 4 and appendices. (author) [French] Dans une premiere partie, l'auteur retrace l'historique des travaux de P. Weiss sur la theorie du champ moleculaire et l'aimantation spontanee; il en souligne les succes dans l'interpretation des proprietes magnetiques et energetiques des corps ferro-magnetiques et les perfectionnements ultimes: champ moleculaire energetique et champ moleculaire correctif de l'equation d'etat. Dans une deuxieme partie, apres avoir examine les difficultes auxquelles se heurtait la theorie, l'auteur montre qu'elles ont ete resolues en introduisant la notion de champ moleculaire local et en donnant ainsi la cle des proprietes des corps antiferro-et ferri-magnetiques. II etudie egalement (paragraphe 4 et Appendice) l'etat actuel de l'interpretation des proprietes magnetiques de la pyrrhotine qui a joue un grand role dans l'histoire du champ moleculaire. (auteur)

  19. Cohabitation sociale et ordre public aux Champs-Élysées :Gestion et appropriation du carré des jeux (1700-1830

    Directory of Open Access Journals (Sweden)

    Véronique Laporte

    2011-08-01

    Full Text Available Au 18e siècle et au début du 19e siècle, les Champs-Élysées sont ouverts à tous et attirent une clientèle diversifiée. Des joueurs issus d’horizons très différents s’y retrouvent pour pratiquer différentes activités, telles que la longue paume, les boules ou les barres. Afin que les promeneurs ne soient pas importunés par les jeux, ces derniers sont confinés dans une vaste clairière servant également lors des revues militaires et des fêtes publiques. Les autorités ont une volonté réelle d’offrir aux visiteurs des espaces de jeux, mais elles craignent aussi les débordements susceptibles d’être créés par les amusements. En effet, qu’importe si les joueurs sont nobles ou écoliers, la même crainte transparaît. Il s’agit de la peur des attroupements. C’est pourquoi les autorités tentent de diminuer l’affluence aux Champs-Élysées en contrôlant le nombre et la nature des jeux pratiqués dans cet espace public.At the end of the 18th century and the beginning of the 19th century, the Champs-Élysées were open to people of all extractions and attracted indeed a diversified public. Players of different social origins gathered for various collective games such as the longue paume, bowls, or "les barres". In order not to disturb the strollers, the games were confined in a clearing also used for military reviews and public celebrations. Authorities had a will to offer playing spaces to visitors, but were at the same time concerned by the possibility of public overflowings. Whether they be aristocrats or schoolboys, the same apprehension comes out: the fear of gatherings. This is the why the authorities attempted to reduce the crowds on the Champs-Élysées by controlling the number and the nature of the games practiced in that public place.

  20. The effect of an homogeneous magnetic field on the line profiles of hydrogen; Effet d'un champ magnetique uniforme sur les profils des raies de l'hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, H; Herman, L [Universite de Paris Sorbonne, Lab. de Recherche Physique, 75 - Paris (France); Drawin, H W [Association Euratom-CEA, Centre d' Etudes Nucleaires de Fontenay-aux-Roses, 92 (France)

    1966-07-01

    numeriques partiels concernant les raies Ly{alpha}, Ly{beta} et H{alpha}. Pour de tres faibles champs magnetiques, les profils que nous avons obtenus se confondent avec les profils de STARK purs, precedemment calcules par GRIEM, KOLB et SHEN (1960). Au fur et a mesure que le champ magnetique augmente, d'importants ecarts apparaissent. Les parametres caracteristiques essentiels de ces ecarts sont, d'une part, l'orientation de la direction d'observation par rapport a celle du champ magnetique, et d'autre part le rapport entre le deplacement ZEEMAN du au champ magnetique seul et le deplacement STARK du au champ electrique intermoleculaire moyen. L'etude experimentale a ete faite au moyen d'un tube a decharge entoure d'une bobine d'induction. La comparaison entre les profils theoriques et les resultats de mesure montre que la concordance est tres satisfaisante. Les resultats concernant les nombres quantiques principaux plus eleves sont en cours d'exploitation et feront partie d'une prochaine communication. (auteur)

  1. Modification de la surface du cuivre par implantation ionique par source plasma (IISP): applications à l’érosion cathodique dans les systèmes à arcs

    OpenAIRE

    Roy, F

    2006-01-01

    L’érosion cathodique est un phénomène bien connu qui limite la durée de vie de l’électrode négative dans les systèmes à arcs. Dans le présent mémoire, nous avons tenté de voir si la formation de précipités nanométriques d’oxyde de cuivre pouvait réduire l’érosion cathodique nécessaire au maintien de l’arc en mode thermo-champ (T-F). Les dits précipités ont été produits par implantation ionique par source plasma (IISP). Avec l’aide de techniques de caractérisation telle que la microscopie à fo...

  2. Modélisation multi-échelles en viscoplasticité endommageable de composites thermoplastiques renforcés par des fibres discontinues

    OpenAIRE

    ACHOUR, Nadia; CHATZIGEORGIOU, George; BONNAY, Kevin; MERAGHNI, Fodil

    2017-01-01

    Un nouveau modèle multi-échelles en régime viscoplastique endommageable est développé pour un composite à matrice polypropylène renforcé par des fibres de verre courtes. Basé sur l’approche en champs moyens de Mori Tanaka, il intègre une matrice viscoplastique modélisée par un modèle phénoménologique nommé par ses auteurs DSGZ et des fibres de verres modélisées par un comportement élastique linéaire. Le modèle multi-échelles permet d’intégrer la microstructure du composite préalablement carac...

  3. Effect of a radial space-charge field on the movement of particles in a magneto-static field and under the influence of a circularly polarized wave; L'effet d'un champ de charge d'espace radial sur le mouvement des particules dans un champ magnetique statique et sous l'action d'une onde polarisee circulairement

    Energy Technology Data Exchange (ETDEWEB)

    Buffa, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-06-15

    The effect of a circularly polarized wave on a cylindrical plasma in a axial magnetostatic field and a radial space-charge field proportional to r is studied. Single particle motion is considered. The electrostatic field produces a shift in the cyclotron resonance frequency and,in case of high charge density, a radial movement of the off-resonance particles. In these conditions a radio-frequency-particle resonance is also possible called 'drift-resonance'. The drift resonance can be produced, with whistler mode, and may be employed in ion acceleration. Afterwards parametrical resonances produced by space-charge field oscillations and collisional limits of theory are studied. Cases in which ion acceleration is possible are considered on the basis of a quantitative analysis of results. (author) [French] On etudie l'effet d'une onde polarisee circulairement sur un plasma cylindrique place dans un champ magnetique axial constant, en supposant etre en presence d'un, champ de charge d'espace radial proportionnel a r. L'etude est faite du point de vue de la particule individuelle. Le champ electrostatique deplace la frequence de resonance cyclotron et, dans le cas de forte densite, donne lieu a un mouvement radial des particules qui ne sont pas en resonance. Dans ces champs, il peut aussi se produire une resonance qu'on a appele 'de derive', entre un R.F. et la particule. Cette resonance peut se produire avec le mode siffleur et peut etre utilisee pour l'acceleration des ions. On considere ensuite les resonances parametriques, qui se manifestent lorsque le champ de charge d'espace oscille, et les limites a la theorie posees par les collisions. Une discussion quantitative des resultats fait ressortir les cas dans lesquels on peut accelerer les ions. (auteur)

  4. VizieR Online Data Catalog: ChaMP X-ray point source catalog (Kim+, 2007)

    Science.gov (United States)

    Kim, M.; Kim, D.-W.; Wilkes, B. J.; Green, P. J.; Kim, E.; Anderson, C. S.; Barkhouse, W. A.; Evans, N. R.; Ivezic, Z.; Karovska, M.; Kashyap, V. L.; Lee, M. G.; Maksym, P.; Mossman, A. E.; Silverman, J. D.; Tananbaum, H. D.

    2009-01-01

    We present the Chandra Multiwavelength Project (ChaMP) X-ray point source catalog with ~6800 X-ray sources detected in 149 Chandra observations covering ~10deg2. The full ChaMP catalog sample is 7 times larger than the initial published ChaMP catalog. The exposure time of the fields in our sample ranges from 0.9 to 124ks, corresponding to a deepest X-ray flux limit of f0.5-8.0=9x10-16ergs/cm2/s. The ChaMP X-ray data have been uniformly reduced and analyzed with ChaMP-specific pipelines and then carefully validated by visual inspection. The ChaMP catalog includes X-ray photometric data in eight different energy bands as well as X-ray spectral hardness ratios and colors. To best utilize the ChaMP catalog, we also present the source reliability, detection probability, and positional uncertainty. (10 data files).

  5. The effect of an alternating electric field on a totally ionised plasma; Action d'un champ electrique alternatif sur un plasma totalement ionise

    Energy Technology Data Exchange (ETDEWEB)

    Baglin, H; Brin, A; Ozias, Y; Salmon, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Delcroix, J L [Ecole Normale Superieure, 75 - Paris (France)

    1960-07-01

    The equation giving the distribution function of the electrons in a steady-state, for a fully ionized plasma in an a.c. field, are provided from the Fokker-Planck equation. The electric conductivity is complex and depends on the frequency. (author) [French] L'equation qui donne la fonction de distribution des electrons dans un etat stationnaire pour un plasma totalement ionise dans un champ electrique alternatif est fournie par l'equation de Fokker-Planck. La conductibilite electrique est complexe et depend de la frequence. (auteur)

  6. Reconstruction de la surface de Fermi dans l'etat normal d'un supraconducteur a haute Tc: Une etude du transport electrique en champ magnetique intense

    Science.gov (United States)

    Le Boeuf, David

    Des mesures de resistance longitudinale et de resistance de Hall en champ magnetique intense transverse (perpendiculaire aux plans CuO2) ont ete effectuees au sein de monocristaux de YBa2Cu3Oy (YBCO) demacles, ordonnes et de grande purete, afin d'etudier l'etat fondamental des supraconducteurs a haute Tc dans le regime sous-dope. Cette etude a ete realisee en fonction du dopage et de l'orientation du courant d'excitation J par rapport a l'axe orthorhombique b de la structure cristalline. Les mesures en champ magnetique intense revelent par suppression de la supraconductivite des oscillations magnetiques des resistances longitudinale et de Hall dans YBa2Cu 3O6.51 et YBa2Cu4O8. La conformite du comportement de ces oscillations quantiques au formalisme de Lifshitz-Kosevich, apporte la preuve de l'existence d'une surface de Fermi fermee a caractere quasi-2D, abritant des quasiparticules coherentes respectant la statistique de Fermi-Dirac, dans la phase pseudogap d'YBCO. La faible frequence des oscillations quantiques, combinee avec l'etude de la partie monotone de la resistance de Hall en fonction de la temperature indique que la surface de Fermi d'YBCO sous-dope comprend une petite poche de Fermi occupee par des porteurs de charge negative. Cette particularite de la surface de Fermi dans le regime sous-dope incompatible avec les calculs de structure de bande est en fort contraste avec la structure electronique presente dans le regime surdope. Cette observation implique ainsi l'existence d'un point critique quantique dans le diagramme de phase d'YBCO, au voisinage duquel la surface de Fermi doit subir une reconstruction induite par l'etablissement d'une brisure de la symetrie de translation du reseau cristallin sous-jacent. Enfin, l'etude en fonction du dopage de la resistance de Hall et de la resistance longitudinale en champ magnetique intense suggere qu'un ordre du type onde de densite (DW) est responsable de la reconstruction de la surface de Fermi. L'analogie de

  7. Scattering of electromagnetic waves by an non-uniform cylindrical plasma; Diffusion coherente d'une onde electromagnetique par un cylindre de plasma inhomogene

    Energy Technology Data Exchange (ETDEWEB)

    Faugeras, P E [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Groupe de recherches sur la fusion controlee

    1967-07-01

    The problem of the scattering of plane electromagnetic waves from a non-uniform, cylindrically symmetrical plasma is solved analytically, by a self-consistent field method, for a wave with the electric field parallel to the cylinder axis. Numerical results for the diffracted field are plotted for interesting ranges of the parameters involved: diameter, density on the axis, radial profile of the density, and collision frequencies. The case where the incident field is cylindric (waves surfaces parallel to the cylinder axis) is examined - this permits to connect theoretical calculations and experimental diffraction patterns, and also to explain the diffraction effects observed in a classical microwave interferometry experiment. These results, and the possibility of measuring exactly the diffracted field (showed by experiments with dielectric and metallic rods) lead to a new plasma diagnostic method, based on the diffraction, which has no theoretical limitations and it usable when the classical free-space wave methods are not (plasma diameter lower than 10 wave lengths). The feasibility of this method is tested with a plasma at atmospheric pressure and a 2 mm incident wavelength. The plasma is obtained by the laminar flow of a plasma torch, with a working gas (He or Ar) seeded by potassium (density continuously variable between 10{sup 11} and 10{sup 15} e/cm{sup 3}. Some diffraction patterns by this plasma and for various incident waves, are also given and explained with theoretical calculations. (author) [French] On etudie la diffusion coherente d'une onde electromagnetique par un cylindre de plasma inhomogene par une methode de champ self-consistant, et pour une onde de vecteur electrique parallele a l'axe du cylindre. On a calcule le champ diffracte en faisant varier le diametre du cylindre, la densite sur l'axe, le profil de densite et les frequences de collisions, et on donne ici les principaux resultats. On examine ensuite le cas d'une onde incidente cylindrique

  8. L’eau, l’écrit et la société. Étude statistique sur les champs sémantiques dans les bases de données [CBMA

    Directory of Open Access Journals (Sweden)

    Nicolas Perreaux

    2011-08-01

    Full Text Available Intitulé « L’eau, l’écrit et la société. Étude statistique sur les champs sémantiques dans les bases de données [CBMA] » , notre mémoire de master partait d’un constat relativement simple : les chartes, ces documents conservés plutôt en grande abondance, contiennent un nombre extrêmement important de termes relatifs à la description et donc, par extension, à la perception du monde par les médiévaux. Or, il est clair que ces formules, plus ou moins stéréotypées, n’ont presque jamais été consid...

  9. Internal consistency of the CHAMPS physical activity questionnaire for Spanish speaking older adults.

    Science.gov (United States)

    Rosario, Martín G; Vázquez, Jenniffer M; Cruz, Wanda I; Ortiz, Alexis

    2008-09-01

    The Community Healthy Activities Model Program for Seniors (CHAMPS) is a physical activity monitoring questionnaire for people between 65 to 90 years old. This questionnaire has been previously translated to Spanish to be used in the Latin American population. To adapt the Spanish version of the CHAMPS questionnaire to Puerto Rico and assess its internal consistency. An external review committee adapted the existent Spanish version of the CHAMPS to be used in the Puerto Rican population. Three older adults participated in a second phase with the purpose of training the research team. After the second phase, 35 older adults participated in a third content adaptation phase. During the third phase, the preliminary Spanish version for Puerto Rico of the CHAMPS was given to the 35 participants to assess for clarity, vocabulary and understandability. Interviews to each participant in the third phase were carried out to obtain feedback and create a final Spanish version of the CHAMPS for Puerto Rico. After analyses of this phase, the external review committee prepared a final Spanish version of the CHAMPS for Puerto Rico. The final version was administered to 15 older adults (76 +/- 6.5 years) to assess the internal consistency by using Cronbach's Alpha analysis. The questionnaire showed a strong internal consistency of 0.76. The total time to answer the questionnaire was 17.4 minutes. The Spanish version of the CHAMPS questionnaire for Puerto Rico suggested being an easy to administer and consistent measurement tool to assess physical activity in older adults.

  10. Propagation and diffusion of a plasma column in a magnetic field; Propagation et diffusion d'une colonne de plasma dans un champ magnetique

    Energy Technology Data Exchange (ETDEWEB)

    Bottiglioni, F; Coutant, J; Gadda, E; Prevot, F [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1966-12-01

    A plasma column is created in a magnetic field by longitudinal diffusion from a low-pressure pulsed discharge in hydrogen. Depending on the discharge conditions, two regimes are obtained in which the gas pumping speed has a different effect upon the plasma density in the column. Calculations are presented which can explain this effect by a difference in the transverse diffusion coefficient. (authors) [French] On forme une colonne de plasma dans un champ magnetique par diffusion longitudinale a partir d'une decharge puisee dans l'hydrogene a basse pression. Selon les conditions de la decharge on observe deux regimes differents pour lesquels le pompage du gaz neutre a un effet different sur la densite resultante du plasma dans la colonne. On presente des calculs qui peuvent expliquer cet effet par une difference dans la diffusion transversale du plasma. (auteurs)

  11. L'analyse par activation de neutrons de réacteur

    Science.gov (United States)

    Meyer, G.

    2003-02-01

    Quand les neutrons traversent la matière, certains sont transmis sans interaction, les autres interagissent avec le milieu traversé par diffusion et par absorption. Ce phénomène d'absorption est utilisé pour se protéger des neutrons, mais aussi pour les détecter; il peut également être utilisé pour identifier les noyaux “absorbants" et ainsi analyser le milieu traversé. En effet par différentes réactions nucléaires (n,γ), (n,p), (n,α), (n,fission), on obtient des noyaux résiduels qui sont souvent radioactifs; on dit que l'échantillon est “activé". Si l'on connaît le rendement d'activation et donc le pourcentage de noyaux ainsi “transmutés", les mesures de radioactivité induite vont permettre de déterminer la composition de l'échantillon irradié. Cette méthode dite d'analyse par activation neutronique est pratiquée depuis la découverte du neutron. Elle a permis grâce à sa sélectivité et à sa sensibilité d'avoir accès au domaine des traces et des ultra-traces dans des champs d'application très divers comme la métallurgie, l'archéologie, la biologie, la géochimie etc...

  12. Contribution to the study of the action of electromagnetic fields on the angular correlations of nuclear radiation (1960); Contribution a l'etude de l'action des champs electromagnetiques sur les correlations angulaires des rayonnements nucleaires (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-01-15

    This work deals with the study of interaction of E.M. fields with nuclear moments of nuclei emitting gamma rays. We describe first experiments on delayed angular correlation showing the role played by statistic quadrupole interaction. We have measured the magnetic moment of the second excited state of {sup 19}F using an external magnetic field. In the case of {sup 19}O, experiments of angular distributions and angular correlations of gamma -rays taking into account the possibility of perturbations, allow us to determine the spin and parities of the three first levels. (author) [French] Le present travail concerne l'etude de l'interaction des champs electromagnetiques et des moments nucleaires de noyaux emettant des rayonnements gamma. Nous decrivons des experiences de correlation angulaire differee dont l'interpretation met en coincidence le role joue par les interactions quadrupolaires statiques. Nous avons mesure le moment magnetique de {sup 19}F dans un etat excite en utilisant un champ magnetique exterieur a la source radioactive. Enfin, dans le cas de {sup 19}O, nous montrons l'utilite d'un examen des possibilites de perturbations dans l'interpretation des resultats fournis par des correlations ou des distributions angulaires. (auteur)

  13. Antoine Béchamp: pere de la biologie. Oui ou non?

    Science.gov (United States)

    Manchester, K L

    2001-06-01

    There is an alternative medicine lobby that, in conjunction with antivivisectionists, believes Louis Pasteur to have been a fraud [R. Bottomley's You Don't Have to Feel Unwell! (Newleaf, 1994) is a recent example]. They frame their accusations around a rivalry between Pasteur and a contemporary, Antoine Béchamp, from whom they suggest Pasteur stole his ideas and then distorted them for his own purposes. This article explores some aspects of the controversies between Béchamp and Pasteur.

  14. Study of FeC1{sub 2} by neutron diffraction; Etude de Fe C1{sub 2} par diffraction de neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Herpin, A; Meriel, P [Commissariat a l' Energie Atomique, Saclay (France)

    1959-07-01

    Magnetic measurements have shown that anhydrous ferrous chloride behaves as a metamagnetic at temperatures below 24 deg. K, in other words as an antiferromagnetic sensitive to the action of an external field of moderate strength. The aim of the neutron diffraction study is to determine precisely the arrangement of the magnetic moments, and to follow its evolution as a function of the applied field. (author) [French] Des mesures magnetiques ont montre que le chlorure ferreux anhydre se comporte comme un metamagnetique a une temperature inferieure a 24 deg. K, c'est a dire comme un antiferromagnetique sensible a l'action d'un champ exterieur modere. L'etude par diffraction de neutrons a pour buts de preciser la disposition des moments magnetiques et de suivre son evolution en fonction du champ applique. (auteur)

  15. Étude par spectroscopie Raman de résonance de composés modèles de la polyaniline

    Science.gov (United States)

    Boyer, M. I.; Quillard, S.; Louarn, G.; Lefrant, S.; Rebourt, E.; Monkman, A.

    1998-06-01

    In this paper, a vibrational study (Resonance Raman Scattering and valence- force-field calculations) of some model compounds of polyaniline is presented. Indeed, this model compound approach allows one to obtain some informations about the vibrational properties and consequently about the electronic configurations of the corresponding polymeric forms. By using valence-force- field calculations, three sets of force constants have been obtained, related to the reduced and oxidized units of the base forms of polyaniline and to the emeraldine salt form. Dans ce travail, nous présentons une étude vibrationnelle (diffusion Raman de résonance et calcul de champ de force de valence) de quelques composés modèles de la polyaniline. Cette approche par les composés modèles permet, en effet, d'obtenir des informations sur les propriétés vibrationnelles et à fortiori sur les configurations électroniques des formes polymères correspondantes. Ainsi, par un calcul de champ de force de valence, trois jeux de constantes ont été déterminés relatifs aux unités réduites et oxydées des différentes formes bases des polyanilines et à la forme éméraldine sel.

  16. Stabilisation en pression et en température du champ magnétique dans le piège à ions de précision d’ISOLTRAP au CERN

    CERN Document Server

    MARIE-JEANNE, M; BAN, G

    2005-01-01

    L’expérience ISOLTRAP, à ISOLDE au CERN, utilise la mesure de la fréquence cyclotron dans un piège de Penning pour en déduire avec une haute précision la masse des ions radioactifs produits par l’installation ISOLDE. Pour cette mesure de masse, une bonne homogénéité du champ magnétique au cours du temps est requise dans le piège. Or l’étude de l’erreur systématique a montré l’existence d’une dérive du champ magnétique en fonction du temps, à laquelle se superposent des fluctuations dépendant de la température. La courbe de dérive linéaire en fonction du temps ayant été évaluée, on souhaite mettre en place un système de régulation permettant d’atténuer les fluctuations du champ magnétique liées aux variations de la température. Ce dispositif constituera une amélioration technique pouvant conduire à la réduction de l’erreur systématique sur la mesure de masse. Ce rapport détaille l’installation d’un système de régulation de la pression de l’hélium ser...

  17. CHaMP metrics - Columbia Habitat Monitoring Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The goal of CHaMP is to generate and implement a standard set of fish habitat monitoring (status and trend) methods in up to 26 watersheds across the Columbia River...

  18. Study of FeC1{sub 2} by neutron diffraction; Etude de Fe C1{sub 2} par diffraction de neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Herpin, A.; Meriel, P. [Commissariat a l' Energie Atomique, Saclay (France)

    1959-07-01

    Magnetic measurements have shown that anhydrous ferrous chloride behaves as a metamagnetic at temperatures below 24 deg. K, in other words as an antiferromagnetic sensitive to the action of an external field of moderate strength. The aim of the neutron diffraction study is to determine precisely the arrangement of the magnetic moments, and to follow its evolution as a function of the applied field. (author) [French] Des mesures magnetiques ont montre que le chlorure ferreux anhydre se comporte comme un metamagnetique a une temperature inferieure a 24 deg. K, c'est a dire comme un antiferromagnetique sensible a l'action d'un champ exterieur modere. L'etude par diffraction de neutrons a pour buts de preciser la disposition des moments magnetiques et de suivre son evolution en fonction du champ applique. (auteur)

  19. Voies de recherche en matière de récupération assistée du pétrole par tensio-actifs Research Lines in Enhanced Oil Recovery by Surfactants

    OpenAIRE

    Baviere M.; Defives D.; Labrid J.; Minssieux L.

    2006-01-01

    Quelle que soit la conjoncture économique, le procédé de récupération assistée du pétrole par injection d'agents tensio-actifs nécessite une mise en oeuvre très élaborée pour tirer le meilleur parti des produits et donc pour franchir le seuil de rentabilité. Il apparaît par ailleurs que son champ d'application doit être étendu aux conditions de réservoir couramment rencontrées, notamment les fortes salinités, par l'utilisation de structures chimiques adaptées. Pour réduire les pertes de tensi...

  20. Analysis on motion of Earth's center of mass observed with CHAMP mission

    Institute of Scientific and Technical Information of China (English)

    GUO JinYun; HAN YanBen; Zhang wei

    2008-01-01

    Geocenter motion (GCM) is one important topic for constructing and maintaining the terrestrial reference frame and its applications. GCM is studied from CHAMP with the multi-step approach in this paper. Geometric orbits of CHAMP in 2001-2006 are precisely determined with the kinematic method only from the satel-lite-borne GPS zero-difference data. Then a GCM time series is estimated from the precise kinematic orbits based on the theory of satellite dynamics to fit the CHAMP's real geometric orbits. We compare the series with the geocenter series used in ITRF2005. Then the GCM series are analyzed with Fourier transform and wavelet transformation. The mean motions within 6 years in TX, TY and TZ direc-tions are respectively 0.8 mm, 2.2 mm, and 7.9 mm. The trends of GCM in the three directions are 0.495 mm/a,-0.004 mm/a, and 1.309 mm/a, respectively. The long-term movement (2001-2006) indicates that the crustal figure is changing. The seasonal variations are the main component which may be excitated by the mass redistribution of Earth's fluid layer, e.g. ocean, atmosphere and continental water. The inter-annual variations are also found in the GCM series measured with CHAMP.

  1. A first analysis of the mean motion of CHAMP

    Directory of Open Access Journals (Sweden)

    F. Deleflie

    2003-01-01

    Full Text Available The present study consists in studying the mean orbital motion of the CHAMP satellite, through a single long arc on a period of time of 200 days in 2001. We actually investigate the sensibility of its mean motion to its accelerometric data, as measures of the surface forces, over that period. In order to accurately determine the mean motion of CHAMP, we use “observed" mean orbital elements computed, by filtering, from 1-day GPS orbits. On the other hand, we use a semi-analytical model to compute the arc. It consists in numerically integrating the effects of the mean potentials (due to the Earth and the Moon and Sun, and the effects of mean surfaces forces acting on the satellite. These later are, in case of CHAMP, provided by an averaging of the Gauss system of equations. Results of the fit of the long arc give a relative sensibility of about 10-3, although our gravitational mean model is not well suited to describe very low altitude orbits. This technique, which is purely dynamical, enables us to control the decreasing of the trajectory altitude, as a possibility to validate accelerometric data on a long term basis.Key words. Mean orbital motion, accelerometric data

  2. The development and implementation of theory-driven programs capable of addressing poverty-impacted children's health, mental health, and prevention needs: CHAMP and CHAMP+, evidence-informed, family-based interventions to address HIV risk and care.

    Science.gov (United States)

    McKernan McKay, Mary; Alicea, Stacey; Elwyn, Laura; McClain, Zachary R B; Parker, Gary; Small, Latoya A; Mellins, Claude Ann

    2014-01-01

    This article describes a program of prevention and intervention research conducted by the CHAMP (Collaborative HIV prevention and Adolescent Mental health Project; McKay & Paikoff, 2007 ) investigative team. CHAMP refers to a set of theory-driven, evidence-informed, collaboratively designed, family-based approaches meant to address the prevention, health, and mental health needs of poverty-impacted African American and Latino urban youth who are either at risk for HIV exposure or perinatally infected and at high risk for reinfection and possible transmission. CHAMP approaches are informed by theoretical frameworks that incorporate an understanding of the critical influences of multilevel contextual factors on youth risk taking and engagement in protective health behaviors. Highly influential theories include the triadic theory of influence, social action theory, and ecological developmental perspectives. CHAMP program delivery strategies were developed via a highly collaborative process drawing upon community-based participatory research methods in order to enhance cultural and contextual sensitivity of program content and format. The development and preliminary outcomes associated with a family-based intervention for a new population, perinatally HIV-infected youth and their adult caregivers, referred to as CHAMP+, is described to illustrate the integration of theory, existing evidence, and intensive input from consumers and healthcare providers.

  3. Cohabitation sociale et ordre public aux Champs-Élysées :Gestion et appropriation du carré des jeux (1700-1830)

    OpenAIRE

    Véronique Laporte

    2011-01-01

    Au 18e siècle et au début du 19e siècle, les Champs-Élysées sont ouverts à tous et attirent une clientèle diversifiée. Des joueurs issus d’horizons très différents s’y retrouvent pour pratiquer différentes activités, telles que la longue paume, les boules ou les barres. Afin que les promeneurs ne soient pas importunés par les jeux, ces derniers sont confinés dans une vaste clairière servant également lors des revues militaires et des fêtes publiques. Les autorités ont une volonté réelle d’off...

  4. CHAMP+ : A powerful array receiver for APEX

    NARCIS (Netherlands)

    Kasemann, C.; Güsten, R.; Heyminck, S.; Klein, B.; Klein, T.; Philipp, S.D.; Korn, A.; Schneider, G.; Henseler, A.; Baryshev, A.; Klapwijk, T.M.

    2006-01-01

    CHAMP+, a dual-color 2 × 7 element heterodyne array for operation in the 450 ?m and 350 ?m atmospheric windows is under development. The instrument, which is currently undergoing final evaluation in the laboratories, will be deployed for commissioning at the APEX telescope in August this year. With

  5. Features of highly structured equatorial plasma irregularities deduced from CHAMP observations

    Science.gov (United States)

    Xiong, C.; Lühr, H.; Ma, S. Y.; Stolle, C.; Fejer, B. G.

    2012-08-01

    In this study five years of CHAMP (Challenging Mini-satellite Payload) fluxgate magnetometer (FGM) data is used to investigate the characteristics of Equatorial Plasma Bubbles (EPBs). We filtered the FGM data by using band-passes with four different cut-off periods to get the EPBs with different maximum spatial scale sizes in the meridional plane ranging from 76-608 km. Associated with the EPB observations at about 400 km, the typical altitude of CHAMP during the year 2000-2005, we also investigate the post-sunset equatorial vertical plasma drift data from ROCSAT-1 (Republic of China Satellite 1). Since the height of the F-layer is highly correlated with the vertical plasma drift and solar flux, we sorted the ROCSAT-1 data into different groups by F10.7. From the integrated vertical drift we have estimated the post-sunset uplift of the ionosphere. By comparing the properties of EPB occurrence for different scale sizes with the global distribution of plasma vertical uplift, we have found that EPBs reaching higher altitudes are more structured than those which are sampled by CHAMP near the top side of the depleted fluxtube. Such a result is in accord with 3-D model simulations (Aveiro and Hysell, 2010). Small-scale EPB structures are observed by CHAMP when the irregularities reach apex heights of 800 km and more. Such events are encountered primarily in the Brazilian sector during the months around November, when the post-sunset vertical plasma drift is high.

  6. Contribution to the study of the action of electromagnetic fields on the angular correlations of nuclear radiation (1960); Contribution a l'etude de l'action des champs electromagnetiques sur les correlations angulaires des rayonnements nucleaires (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-01-15

    This work deals with the study of interaction of E.M. fields with nuclear moments of nuclei emitting gamma rays. We describe first experiments on delayed angular correlation showing the role played by statistic quadrupole interaction. We have measured the magnetic moment of the second excited state of {sup 19}F using an external magnetic field. In the case of {sup 19}O, experiments of angular distributions and angular correlations of gamma -rays taking into account the possibility of perturbations, allow us to determine the spin and parities of the three first levels. (author) [French] Le present travail concerne l'etude de l'interaction des champs electromagnetiques et des moments nucleaires de noyaux emettant des rayonnements gamma. Nous decrivons des experiences de correlation angulaire differee dont l'interpretation met en coincidence le role joue par les interactions quadrupolaires statiques. Nous avons mesure le moment magnetique de {sup 19}F dans un etat excite en utilisant un champ magnetique exterieur a la source radioactive. Enfin, dans le cas de {sup 19}O, nous montrons l'utilite d'un examen des possibilites de perturbations dans l'interpretation des resultats fournis par des correlations ou des distributions angulaires. (auteur)

  7. Use of a Monte-Carlo method for studying the statistical distribution of electric fields around an ion in a one-component plasma; Etude, par une methode de Monte-Carlo de la repartition statistique des champs electriques au niveau d'un ion, dans un plasma a une composante

    Energy Technology Data Exchange (ETDEWEB)

    Rossignol-Guzzi, D [Commissariat a l' Energie Atomique, 94 - Limeil-Brevannes (France). Centre d' Etudes Nucleaires

    1968-11-01

    A Monte-Carlo simulation has been made of the equilibrium configurations taken by a plasma of equally charged punctual ions, immersed in a uniform neutralizing background of electrons. The statistical repartition of the electric field acting on one ion, needed to obtain Stark effect, was specially obtained. Comparison for dense plasmas, was made with the former works of Holtzmark, Mayer, Broyles. (author) [French] On simule sur ordinateur, suivant une methode de Monte-Carlo, les configurations prises a l'equilibre thermodynamique par un plasma d'ions ponctuels et de meme charge, places dans un milieu d'electrons uniformement distribues. On etudie, en particulier, la repartition statistique des champs electriques au niveau d'un ion, utilisee dans les calculs d'effets Stark. On compare, dans le cadre des plasmas denses, les resultats obtenus aux travaux precedents de Holtzmark, Mayer, Broyles. (auteur)

  8. Modélisation du champ magnétique d'un propulseur M.H.D. annulaire

    OpenAIRE

    Kom , C.; Brunet , Y.

    1995-01-01

    Pour des raisons de discrétion, les champs de fuite doivent être minimisés en propulsion M.H.D. où les champs magnétiques doivent être intenses. Le calcul du champ magnétique d'un propulseur M.H.D. naval annulaire, constitué de secteurs inducteurs supraconducteurs est représenté. Dans la zone active, hors des têtes de bobines, une formulation analytique peut être utilisée. Une méthode analytique utilisant le développemment en série de Fourier du courant est adoptée pour les industeurs cylindr...

  9. Project CHAMP, 1986-1987. OEA Evaluation Report.

    Science.gov (United States)

    Cabrera, Eulalia; And Others

    In its fourth year, Project CHAMP (Chinese Achievement and Mastery Program) provided instruction in English as a second language (ESL), native language arts, mathematics, science, and social studies to 728 limited-English-speaking Chinese immigrant students in grades nine through twelve at three schools. Content-area classes were taught in English…

  10. Project CHAMP, 1985-1986. OEA Evaluation Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn. Office of Educational Assessment.

    The Chinese Achievement and Mastery program, Project CHAMP, was a bilingual (Chinese/English) project offered at three high schools in Manhattan. The major goals were to enable Chinese students of limited English proficiency (LEP) to learn English and to master content in mathematics, science, global history, computer mathematics, and native…

  11. CHAMP + : A powerful array receiver for APEX

    NARCIS (Netherlands)

    Kasemann, C.; Güsten, R.; Heyminck, S.; Klein, B.; Klein, T.; Philipp, S. D.; Korn, A.; Schneider, G.; Henseler, A.; Baryshev, A.; Klapwijk, T. M.

    2006-01-01

    CHAMP +, a dual-color 2 × 7 element heterodyne array for operation in the 450 μm and 350 μm atmospheric windows is under development. The instrument, which is currently undergoing final evaluation in the laboratories, will be deployed for commissioning at the APEX telescope in August this year. With

  12. Magnetic perturbations seen by CHAMP and evaluated using the TIE-GCM

    Directory of Open Access Journals (Sweden)

    D. T. Mozzoni

    2007-07-01

    Full Text Available The Thermosphere-Ionosphere Electrodynamics General Circulation Model (TIE-GCM is a self-consistent, global, atmospheric model that can be used to estimate magnetic perturbations at satellite altitude. These computed perturbations can then be compared with the magnetic vector data provided by low-earth orbiting satellites. In this initial study, the quietest day of each month from 2001–2005 was selected for comparison. CHAMP magnetic vector residuals were computed for these intervals using the CHAOS model to remove core and crustal geomagnetic contributions. Under various input parameters, the TIE-GCM predictions were compared with the CHAMP residuals on an orbit by orbit basis. Initial results demonstrate a reasonable agreement between the TIE-GCM estimates and the CHAMP residuals in non-polar, dayside regions (±50° magnetic latitude where both are able to resolve the Equatorial Electro-Jet (EEJ and solar quiet (Sq current systems. Although no clear component or temporal correlation was discerned, evidence showing the decrease in residual comparisons presents the possibility of using the TIE-GCM to pre-process geomagnetic data for main field modeling purposes.

  13. Features of highly structured equatorial plasma irregularities deduced from CHAMP observations

    Directory of Open Access Journals (Sweden)

    C. Xiong

    2012-08-01

    Full Text Available In this study five years of CHAMP (Challenging Mini-satellite Payload fluxgate magnetometer (FGM data is used to investigate the characteristics of Equatorial Plasma Bubbles (EPBs. We filtered the FGM data by using band-passes with four different cut-off periods to get the EPBs with different maximum spatial scale sizes in the meridional plane ranging from 76–608 km. Associated with the EPB observations at about 400 km, the typical altitude of CHAMP during the year 2000–2005, we also investigate the post-sunset equatorial vertical plasma drift data from ROCSAT-1 (Republic of China Satellite 1. Since the height of the F-layer is highly correlated with the vertical plasma drift and solar flux, we sorted the ROCSAT-1 data into different groups by F10.7. From the integrated vertical drift we have estimated the post-sunset uplift of the ionosphere. By comparing the properties of EPB occurrence for different scale sizes with the global distribution of plasma vertical uplift, we have found that EPBs reaching higher altitudes are more structured than those which are sampled by CHAMP near the top side of the depleted fluxtube. Such a result is in accord with 3-D model simulations (Aveiro and Hysell, 2010. Small-scale EPB structures are observed by CHAMP when the irregularities reach apex heights of 800 km and more. Such events are encountered primarily in the Brazilian sector during the months around November, when the post-sunset vertical plasma drift is high.

  14. caracterisation agro-ecologique du terroir de la nema en zone

    African Journals Online (AJOL)

    AISA

    utilisation des terres constituées par les champs. Les observations ont consisté en des relevés de végétation. Soumis à l'analyse factorielle, ces relevés font apparaître trois groupes de champs : les champs de l'amont, les champs de versants ...

  15. Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation

    Science.gov (United States)

    Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

    2002-01-01

    The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

  16. Applied Technologies and Prospects of Conformance Control Treatments in China Technologies et perspectives pour l’amélioration du profil de balayage dans les champs pétroliers matures produits par injection d’eau en Chine

    Directory of Open Access Journals (Sweden)

    Liu Yuzhang

    2010-02-01

    Full Text Available China is the largest user of chemical-based conformance control treatments and a series of technologies have been successfully developed and deployed in recent years. This paper first shows the milestones of development and application of conformance control technologies in China. Then integrated conformance control technologies are reviewed followed by the lessons we have learned, and then a few major specific conformance control technologies are addressed, including tracer injection and channels explanation, potentiometric testing to identify areal sweep efficiency, Pressure Index (PI decisionmaking technology to select well candidate, complementary decision-making technology to select well candidate and design application parameters, and major chemicals for in-depth fluid diversion technologies. In addition, this paper also describes the principles and applications of some promising technologies of combined chemical-based conformance treatment with other EOR/IOR process, including the combination technology of surfactant and water shutoff, profile control and mini-scale surfactant flooding, acid treatment and profile control treatment. Finally, this paper summarizes the problems and challenges faced by mature water flooded oilfields in China. Based on recent well tests, tracer testing and interpretation, and previous water control treatment experience, it appears that channels or high permeability streaks are common in mature water flooded oilfields. Some research directions and promising technologies are suggested. La Chine est le plus grand utilisateur de méthodes chimiques pour l’amélioration du profil de balayage de l’eau pour l’exploitation des champs pétroliers matures. Toute une série de technologies y ont d’ailleurs été créées et déployées avec succès ces dernières années. Cet article commence par présenter les étapes du développement et de la mise en place de ces technologies de contrôle de profil en Chine

  17. ChAMP: updated methylation analysis pipeline for Illumina BeadChips.

    Science.gov (United States)

    Tian, Yuan; Morris, Tiffany J; Webster, Amy P; Yang, Zhen; Beck, Stephan; Feber, Andrew; Teschendorff, Andrew E

    2017-12-15

    The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell-type heterogeneity, network analysis and a series of interactive graphical user interfaces. ChAMP is a BioC package available from https://bioconductor.org/packages/release/bioc/html/ChAMP.html. a.teschendorff@ucl.ac.uk or s.beck@ucl.ac.uk or a.feber@ucl.ac.uk. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

  18. Thermospheric zonal mean winds and tides revealed by CHAMP

    NARCIS (Netherlands)

    Lieberman, R.S.; Akmaev, R.A.; Fuller-Rowell, T.J.; Doornbos, E.

    2013-01-01

    We present direct, global observations of longitudinally averaged CHAMP zonal winds gathered between 2003 and 2007. A diurnal variation dominates the global zonal wind. Westward flows are observed from the early morning through afternoon hours, while eastward flows peak in the evening. A semidiurnal

  19. Low latitude electron temperature observed by the CHAMP satellite

    DEFF Research Database (Denmark)

    Stolle, Claudia; Truhlik, V.; Richards, P.

    2012-01-01

    Te morning overshoot (MO). Both, data and model revealed an anti-correlation between the equatorial MO amplitude and solar EUV flux at these altitudes. The CHAMP observations also reveal a post sunset electron temperature anomaly in analogy to the equatorial ionisation anomaly at altitudes below 400...

  20. Champ de production littéraire: impérialisme sociologique ou esthétisation de la socologie?

    Directory of Open Access Journals (Sweden)

    Birešev Ana

    2007-01-01

    Full Text Available (francuski Dans la première partie de ce texte l’auteure traite des conséquences théoriques et méthodologiques de l’utilisation du concept de champ de Pierre Bourdieu dans l’exploration du domaine de la production littéraire. Ces conséquences sont examinées à travers les oppositions caractéristiques de la sociologie traditionnelle de l’art et de la littérature, entre la sociologie et l’herméneutique, l’analyse externe et l’analyse interne, le contexte et le texte, le contenu et la forme, le social et l’esthétique. La deuxième partie est consacrée à l’analyse des idées principales de la sociologie de la production culturelle de Bourdieu. La théorie du champ littéraire que Bourdieu propose permet de comprendre la spécificité des propriétés et des lois du champ de la production littéraire. On examine ici dans quelle mesure ce sociologue a modifié sa méthode d’analyse pour construire réellement le champ des producteurs d’oeuvres culturelles, le champ des oeuvres, ainsi que le système des relations qui s’établissent entre ces deux ensembles de relations.

  1. Stability of a Magnetically Confined 20-KeV Steady-State Plasma; Stabilite d'un Plasma Stationnaire de 20 KeV Confine par un Champ Magnetique; Ustojchivost' 20 KehV-statsionarnoj plazmy, uderzhivaemoj magnitnym polem; Estabilidad en Regimen Estacionario de un Plasma de 20 KeV Confinado Magneticamente

    Energy Technology Data Exchange (ETDEWEB)

    Futch, Jr., A. H.; Damm, C. C.; Foote, J. H.; Freis, R.; Gordon, F. J.; Hunt, A. L.; Killeen, J.; Moses, K. G.; Post, R. F.; Steinhaus, J. F. [Lawrence Radiation Laboratory, Livermore, CA (United States)

    1966-04-15

    oscillations at the ion gyrofrequency and with pulsed emission of electrons through the mirror region accompanied by increases in the plasma potential suggests the presence of an electrostatic resonance instability. Differences in gyrofrequency activity among simple mirror, dodecapole and octopole cases are described but specific mode identification is not yet possible. (author) [French] Les auteurs ont etudie la stabilite d'un plasma d'hydrogene stationnaire de 20 keV dans l'appareil a injection d'atomes neutres 'Alice ' de Livermore, dans differents champs magnetiques de confinement. Dans un champ simple a miroirs, l'observation d'oscillations a basse frequence et d'une limite de la densite des ions pieges fait l'objet d'une interpretation en fonction de l'instabilite de derive a basse frequence. Les auteurs ont effectue un traitement theorique de cette instabilite qui porte sur les effets de la dimension finie des orbites des ions, les effets d'un champ electrique d'ordre zero et les effets de la difference entre la densite des ions et celle des electrons. Le champ electrique et le champ magnetique peuvent etre des fonctions arbitraires de la coordonnee spatiale r. Comme il n'est pas possible en general de resoudre analytiquement les equations differentielles ainsi calculees, les auteurs ont resolu numeriquement les equations fondamentales par la methode des differences finies. Ces resultats, qui concordent avec les solutions analytiques obtenues dans le cas limite d'un champ electrique qui n'est pas d'ordre zero, permettent d'expliquer les variations de la densite et de la frequence de la derive observees experimentalement en presence d'un champ electrique fini d'ordre zero. Comme ce traitement theorique part de l'hypothese que le champ magnetique est une fonction arbitraire de r, il est possible d'obtenir des resultats pour des champs ayant un gradient d'abord negatif qui devient ensuite positif lorsque r augmente. Les auteurs comparent les resultats de ces calculs aux

  2. Simultaneous ground-satellite observations of daytime traveling ionospheric disturbances over Japan using the GPS-TEC network and the CHAMP satellite

    Science.gov (United States)

    Moral, A. C.; Shiokawa, K.; Otsuka, Y.; Liu, H.; Nishioka, M.; Tsugawa, T.

    2017-12-01

    We report results of simultaneous ground-satellite measurements of daytime travelling ionospheric disturbances (TIDs) over Japan by using the GEONET GPS receiver network and the CHAMP satellite. For the two years of 2002 and 2008, we examined GPS measurements of TEC (Total Electron Content) and neutral and electron densities measured by CHAMP satellite. Total of fifteen TID events with clear southward moving structures in the GPS-TEC measurements are found by simultaneous ground-satellite measurements. On 2002, simultaneous events are only observed in January (1 event) and February (4 events). On 2008, ten events are observed around winter months (January (3 events), February (5), March (1), and October (1)). Neutral and electron densities measured by CHAMP show quasi-periodic fluctuations throughout the passages for all events. The CHAMP satellite crossed at least one clear TID phase front for all the events. We fitted a sinusoidal function to both ground and satellite data to obtain the frequencies and phase of the observed variations. We calculated the corresponding phase relationships between TEC variations and neutral and electron densities measured by CHAMP to categorize the events. In the presentations we report correspondence of these TID structures seen in the simultaneous ground-satellite observations by GPS-TEC and CHAMP, and discuss their phase relationship to identify the source of the daytime TIDs and specify how much of the observed variations are showing clear frequencies/or not in the nature at middle latitudes.

  3. Performances d'une nouvelle approche dans l'estimation au champ

    African Journals Online (AJOL)

    ACSS

    Elle possède cependant des limitations, dues à l'organisation temporaire d'une .... Performances d'une nouvelle approche dans l'estimation au champ utilisant le principe de la ... différents types de résidus (soja, luzerne, haricot et maïs) et ...

  4. THE MEDDLING OF THE LANGUAGE FUNCTIONS WHIT THE LEXICAL FIELDS OF THE COCA-COLA BRAND SLOGANS

    Directory of Open Access Journals (Sweden)

    Mărioara VLIONCU

    2013-10-01

    Full Text Available Le but de cet etude a été celui de presenter quelques aspects qui visent la liaison qui peut se faire entre les fonctions de la langue telles comme ells sont théorisées par le linguiste Roman Kakobson et les champs lexicaux des slogans de la marquee « Coca-Cola » qui peut être circonscrite à une structure théorique qui appartient à l’acte communicationnel. Les champs lexicaux d’un objet notionnel, respectivement le boisson gazéifié « Coca-Cola », et une structure théorique spécifique à un acte communicationnel base sur le langage. Pour chaque des fonctions du language, telles comme elles ont été théorisées par le linguiste Roman Jakobson, ont été trouvées des correspondances des champs lexicaux, appartenant aux slogans de la marque « Coca-Cola » . Ces champs lexicaux ont été considérablement étendus par des exemples prépondérente de la sphère verbale.

  5. Le point de vue, Cahiers de praxématique n° 41, coordonné par Alain Rabatel, Montpellier, 2003

    Directory of Open Access Journals (Sweden)

    2005-07-01

    Full Text Available Ce numéro des Cahiers de praxématique est consacré au point de vue. Cette notion utilisée d’abord par la critique littéraire (Pouillon en 1946 est ensuite passée au champ de la linguistique du discours (Ducrot en 1984. Pour la narratologie, le PDV (point de vue « traite de la prise en charge des informations narratives ». Selon l’approche de Gérard Genette, qui lui a substitué le terme de focalisation, si c’est bien le narrateur qui raconte, les événements sont représentés soit à partir de...

  6. Analysis on motion of Earth’s center of mass observed with CHAMP mission

    Institute of Scientific and Technical Information of China (English)

    HWANG; CheinWay

    2008-01-01

    Geocenter motion (GCM) is one important topic for constructing and maintaining the terrestrial reference frame and its applications. GCM is studied from CHAMP with the multi-step approach in this paper. Geometric orbits of CHAMP in 2001-2006 are precisely determined with the kinematic method only from the satel-lite-borne GPS zero-difference data. Then a GCM time series is estimated from the precise kinematic orbits based on the theory of satellite dynamics to fit the CHAMP’s real geometric orbits. We compare the series with the geocenter series used in ITRF2005. Then the GCM series are analyzed with Fourier transform and wavelet transformation. The mean motions within 6 years in TX, TY and TZ direc-tions are respectively 0.8 mm, 2.2 mm, and 7.9 mm. The trends of GCM in the three directions are 0.495 mm/a, -0.004 mm/a, and 1.309 mm/a, respectively. The long-term movement (2001-2006) indicates that the crustal figure is changing. The seasonal variations are the main component which may be excitated by the mass redistribution of Earth’s fluid layer, e.g. ocean, atmosphere and continental water. The inter-annual variations are also found in the GCM series measured with CHAMP.

  7. The structure of low-latitude Pc3 pulsations observed by CHAMP and on the ground

    Directory of Open Access Journals (Sweden)

    D. C. Ndiitwani

    2009-03-01

    Full Text Available The structure of low-latitude continuous pulsations termed Pc3, which are naturally occurring MHD waves in the Earth's magnetosphere, were studied by comparing ground and satellite magnetic field measurements. Data from two induction magnetometers, located at Hermanus and Sutherland in South Africa were used in conjunction with Challenging Minisatellite Payload (CHAMP satellite observations to study a Pc3 event observed on 15 February 2003, at a time when CHAMP was passing over the ground stations. We observed a number of discrete frequency oscillations for the fast mode wave, one of which drives a field line resonance (FLR at characteristic latitude as detected by both ground and satellite measurements. Consequently, our observations confirmed the compressional wave as being the driver of the field line resonance. The toroidal mode frequency observed on CHAMP experienced a Doppler frequency shift due to the rapid motion across the resonance region. Polarization hodograms in the resonance region clearly showed the expected 90° rotation of the field line resonant magnetic field components.

  8. The structure of low-latitude Pc3 pulsations observed by CHAMP and on the ground

    Directory of Open Access Journals (Sweden)

    D. C. Ndiitwani

    2009-03-01

    Full Text Available The structure of low-latitude continuous pulsations termed Pc3, which are naturally occurring MHD waves in the Earth's magnetosphere, were studied by comparing ground and satellite magnetic field measurements. Data from two induction magnetometers, located at Hermanus and Sutherland in South Africa were used in conjunction with Challenging Minisatellite Payload (CHAMP satellite observations to study a Pc3 event observed on 15 February 2003, at a time when CHAMP was passing over the ground stations. We observed a number of discrete frequency oscillations for the fast mode wave, one of which drives a field line resonance (FLR at characteristic latitude as detected by both ground and satellite measurements. Consequently, our observations confirmed the compressional wave as being the driver of the field line resonance. The toroidal mode frequency observed on CHAMP experienced a Doppler frequency shift due to the rapid motion across the resonance region. Polarization hodograms in the resonance region clearly showed the expected 90° rotation of the field line resonant magnetic field components.

  9. Présentation Presentation

    Directory of Open Access Journals (Sweden)

    Laurence Husson

    2012-10-01

    Full Text Available La santé, le traitement de la maladie et du malheur sont un champ de recherche relativement neuf pour les sciences sociales. Ce champ se divise schématiquement en deux parties : les représentations et pratiques populaires, d’une part, et le système de santé moderne, d’autre part, étudiées majoritairement par des historiens et par des anthropologues. Par ailleurs, face à ses deux imposants voisins, La Chine et l’Inde, détenteurs de médecines savantes millénaires, l’Asie du Sud-Est, pourtant si...

  10. Indicators to assess the environmental performances of an innovative subway station : example of Noisy-Champs

    Science.gov (United States)

    Schertzer, D. J. M.; Charbonnier, L.; Versini, P. A.; Tchiguirinskaia, I.

    2017-12-01

    Noisy-Champs is a train station located in Noisy-le-Grand and Champs-sur-Marne, in the Paris urban area (France). Integrated into the Grand Paris Express project (huge development project to modernise the transport network around Paris), this station is going to be radically transformed and become a major hub. Designed by the architectural office Duthilleul, the new Noisy-Champs station aspires to be an example of an innovative and sustainable infrastructure. Its architectural precepts are indeed meant to improve its environmental performances, especially those related to storm water management, water consumption and users' thermal and hygrometric comfort. In order to assess and monitor these performances, objectives and associated indicators have been developed. They aim to be adapted for a specific infrastructure such as a public transport station. Analyses of pre-existing comfort simulations, blueprints and regulatory documents have led to identify the main issues for the Noisy-Champs station, focusing on its resilience to extreme events like droughts, heatwaves and heaxvy rainfalls. Both objectives and indicators have been proposed by studying the space-time variabilities of physical fluxes (heat, pollutants, radiation, wind and water) and passenger flows, and their interactions. Each indicator is linked to an environmental performance and has been determined after consultation of the different stakeholders involved in the rebuilding of the station. It results a monitoring program to assess the environmental performances of the station composed by both the indicators grid and their related objectives, and a measurement program detailing the nature and location of sensors, and the frequency of measurements.

  11. Protection des ions organiques contre les dommages induits a l'ADN par les electrons de basse energie

    Science.gov (United States)

    Dumont, Ariane

    'ADN de differentes epaisseurs, possedant entre 0 et 32 ions organiques/ nucleotide, ont ete irradies avec des electrons de 10eV. Les dommages induits par les electrons, sous forme de cassures, ont ete detectes par electrophorese. Nous avons demontre que le rendement de cassure simple brin diminuait de facon dramatique en fonction du nombre d'ions organiques/ nucleotide. Aussi peu que 2 ions organiques/ nucleotide sont suffisant pour decroitre le rendement de SSB de 70%. Cet effet radioprotecteur est en partie explique par l'augmentation de l'epaisseur des films, mais surtout par la modification du champ electrique a proximite de l'ADN, due a l'ajout de molecules chargees positivement. La modification du champ electrique pres de l'ADN altere les parametres de resonance comme le temps de vie de l'anion transitoire et la limite de dissociation, qui influent directement sur la section efficace d'attachement dissociatif. L'effet protecteur peut egalement etre explique par la restauration des bases anioniques deshydrogenees induites par l'attachement dissociatif de l'electron sur une base (G(-H)-). Ce sont les molecules Tris qui, en transferant un atome d'hydrogene ou un proton, restaurent les bases deshydrogenees et inhibent par le fait meme la formation de cassures simple brin. Ces resultats indiquent que les histones peuvent egalement participer a la reparation de dommages precoces induits a l'ADN avant qu'elles ne menent a des dommages encore plus nocifs et difficiles a reparer, comme les cassures simples brins. Mots cles : Electrons de basse energie, dommage a l'ADN, ions organiques, attachement dissociatif de l'electron.

  12. Inter-Diffusion of Plasma and Magnetic Fields in Pinch and Hardcore Discharges; Interdiffusion d'un Plasma et de Champs Magnetiques dans la Striction Rectiligne et la Striction Tubulaire; Vzaimnaya diffuziya plazmy i magnitnogo polya v pinch-razryadakh i razryadakh v tverdoj serdtsevine; Interdifusion Plasma-Campo Magnetico en Descargas de Estriccion y de Nucleo Rigido

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, P.; Lees, D. J.; Bickerton, R. J.; Hardcastle, R. A.; Wetherell, A. T.; White, B. M. [United Kingdom Atomic Energy Authority, Culham Laboratory, Abingdon, Berks. (United Kingdom)

    1966-04-15

    The inter-diffusion of plasma and magnetic field is studied in pinch and hardcore discharges in a large bore, linear discharge tube (TIBER). The variation with magnetic field configuration, initial pressure, peak current, pre-heat conditions and rise time is found. The rapid ('anomalous') field diffusion found in the pinch case is due to a hydromagnetic rather than an electrostatic instability. (author) [French] Les auteurs etudient l'interdiffusion d'un plasma et de champs magnetiques dans la striction rectiligne et la striction tubulaire, au moyen d'une chambre a decharge droite de grand diametre (TIBER). Ils en determinent les variations selon la configuration du champ magnetique, la pression initiale, le courant maximum, les conditions de preechauffage et le temps de montee. La diffusion du champ rapide (anormale) constatee dans le cas de la striction rectiligne s'explique par une instabilite hydromagnetique et non par une instabilite electrostatique. (author) [Spanish] Se estudia la interdifusion plasma-campo magnetico en descargas de estriccion y de nucleo rigido utilizando una camara lineal de descarga de gran diametro interno (TIBER). Se determina la variacion segun la configuracion del campo magnetico, la presion inicial, la intensidad maxima de corriente, las condiciones de precalentamiento y el tiempo de crecimiento. La rapida difusion de los campos ('difusion anomala') observada en el caso de la estriccion se debe mas a una inestabilidad hidromagnetica que a una electrostatica. (author) [Russian] Vzaimnaja diffuzija plazmy i magnitnogo polja issleduetsja v pinch-razrjadah i razrjadah v tverdoj serdcevine v linejnoj razrjadnoj trubke bol'shogo diametra (Tiber). Opredeljajutsja izmenenie konfiguracii magnitnogo polja, nachal'noe davlenie, pikovyj tok, uslovija predvaritel'nogo nagreva i vremja pod'ema. Pokazyvaetsja, chto bystraja (''anomal'naja'') diffuzija polja, ustanovlennaja pri pinche, imeet mesto skoree iz-za gidromagnitnoj, chem iz

  13. An Exospheric Temperature Model Based On CHAMP Observations and TIEGCM Simulations

    Science.gov (United States)

    Ruan, Haibing; Lei, Jiuhou; Dou, Xiankang; Liu, Siqing; Aa, Ercha

    2018-02-01

    In this work, thermospheric densities from the accelerometer measurement on board the CHAMP satellite during 2002-2009 and the simulations from the National Center for Atmospheric Research Thermosphere Ionosphere Electrodynamics General Circulation Model (NCAR-TIEGCM) are employed to develop an empirical exospheric temperature model (ETM). The two-dimensional basis functions of the ETM are first provided from the principal component analysis of the TIEGCM simulations. Based on the exospheric temperatures derived from CHAMP thermospheric densities, a global distribution of the exospheric temperatures is reconstructed. A parameterization is conducted for each basis function amplitude as a function of solar-geophysical and seasonal conditions. Thus, the ETM can be utilized to model the thermospheric temperature and mass density under a specified condition. Our results showed that the averaged standard deviation of the ETM is generally less than 10% than approximately 30% in the MSIS model. Besides, the ETM reproduces the global thermospheric evolutions including the equatorial thermosphere anomaly.

  14. La genèse du concept de champ quantique

    Science.gov (United States)

    Darrigol, O.

    This is a historical study of the roots of a concept which has proved to be essential in modern particle physics : the concept of quantum field. The first steps were accomplished by two young theoreticians : Pascual Jordan quantized the free electromagnetic field in 1925 by means of the formal rules of the just discovered matrix mechanics, and Paul Dirac quantized the whole system charges + field in 1927. Using Dirac's equation for electrons (1928) and Jordan's idea of quantized matter waves (second quantization), Werner Heisenberg and Wolfgang Pauli provided in 1929-1930 an extension of Dirac's radiation theory and the proof of its relativistic invariance. Meanwhile Enrico Fermi discovered independently a more elegant and pedagogical formulation. To appreciate the degree of historical necessity of the quantization of fields, and the value of contemporaneous critics to this approach, it was necessary to investigate some of the history of the old radiation theory. We present the various arguments however provisional or naïve or wrong they could be in retrospect. So we hope to contribute to a more vivid picture of notions which, once deprived of their historical setting, might seem abstruse to the modern user. Nous présentons une étude historique des origines d'un concept devenu essentiel dans la physique moderne des particules : le concept de champ quantique. Deux jeunes théoriciens franchirent les premières étapes : Pascual Jordan quantifia le champ électromagnétique en 1925 grâce aux règles formelles de la mécanique des matrices naissante, et Paul Dirac quantifia le système complet charges + champ en 1927. Au moyen de l'équation de l'électron de Dirac (1928) et de l'idée de Jordan d'ondes de matière quantifiées (deuxième quantification), Werner Heisenberg et Wolfgang Pauli donnèrent en 1929-1930 une extension de la théorie du rayonnement de Dirac et la preuve de son invariance relativiste. Pendant ce temps Enrico Fermi découvrit ind

  15. The beam-kicker system of the synchrotron Saturne. Magnetic field and particle orbit computations. Experimental results (1963); Le percuteur de faisceau de Saturne. Calcul du champ magnetique et des trajectoires. Verifications experimentales (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Gouttefangeas, M; Katz, A; Rastoix, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    In this report is briefly described the beam-kicker system of the synchrotron Saturne. An analysis of its operation based on the sampling method is given, as well as two methods for computing toe magnetic field produced by a set of endless conductors in the neighbourhood of a conducting shield where eddy currents are circulating. The first method leads to the resolution of a bi-dimensional Laplace equation with first kind boundary conditions (Dirichlet problem); the second one translates to electromagnetism the electrical images method currently used in electrostatics and yields the magnetic field as the sum of a triple series expansion in the general case of a set of conductors located in a parallelepipedal box. Finally are given the results obtained in computing on IBM 7090 the perturbation of the particle motion due to the beam-kicker. These results are compared with the experimental data. (authors) [French] Ce rapport decrit brievement le dispositif percuteur de faisceau mis en place sur le synchrotron Saturne. On y trouvera une analyse de se fonctionnement a partir de la theorie des echantillonnages. On indique egalment deux methodes de calcul du champ magnetique produit par un system de conducteurs indefinis en presence d'un blindage conducteur parcouru par des courants de Foucault: la premiere se ramene a la resolution d'une equation de Laplace a deux dimensions avec des conditions aux limites de premiere espece (probleme de Dirichlet), la seconde transpose en electromagnetisme la methode des images electriques classique en electrostatique et permet d'exprimer le champ magnetique sous la forme de la somme d'une serie triple dans le cas general d'un systeme de conducteurs contenus dans un blindage parallelepipedique. Pour terminer, on mentionne les resultats du calcul numerique de la perturbation de la trajectoire des particules sous l'effet du percuteur et on compare ces resultats aux resultats experimentaux. (auteurs)

  16. Notes on the creation of high magnetic fields. Cooling of the coils; Considerations sur la creation de champs magnetiques eleves. Refroidissement des bobines

    Energy Technology Data Exchange (ETDEWEB)

    Armand, G [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    When the temperature of a conductor is lowered, its resistance decreases appreciably. This fact can be made particular use of in the production of high magnetic fields, to reduce the total energy consumed for a given coil. In this paper the problem of the evacuation of heat is examined, and the various fluids which can be used are compared from the viewpoint of the maximum fields attainable from them for a given coil. These fluids are: - water (nucleate boiling); - liquid nitrogen; - liquid hydrogen; - helium at a temperature of 20 deg. K; - helium at a temperature of 10 deg. K. First of all a method for calculating the quantities of heat evacuated by a fluid is established, using general equations for fluid flow with heat exchange. (author) [French] Lorsque l'on abaisse la temperature d'un conducteur, sa resistivite diminue d'une facon sensible. Ce fait peut etre mis a profit notamment en vue de la production de champs magnetiques eleves, de facon a reduire l'energie totale consommee pour une bobine donnee. Dans ce qui suit, le probleme de l'evacuation des pertes Joules est examinee et les differents fluides utilisables sont compares du point de vue des champs maximum qu'ils permettent d'atteindre pour une bobine donnee. Ces fluides sont: - l'eau (nucleate boiling); - l'azote liquide; - l'hydrogene liquide; - l'helium a une temperature de 20 deg. K; - l'helium a une temperature de 10 deg. K. Au prealable une methode de calcul des quantites de chaleur evacuee par un fluide est etablie, a partir des equations globales de dynamique des fluides avec echange de chaleur. (auteur)

  17. Tectonic Interpretation of CHAMP Geopotential Data over the Northern Adriatic Sea.

    Science.gov (United States)

    Taylor, P. T.; Kim, H. R.; Mayer-Gürr, T.

    2006-05-01

    Recent aeromagnetic anomaly compilations (Chiappini et al., 2000 and Tontini et al., 2004) show a large positive (>700 nT) northwest-southeast trending magnetic anomaly off the Dalmatian coast. Unfortunately these aeromagnetic data cover only a part of this anomaly. We wanted to investigate if this large magnetic anomaly could be detected at satellite altitude and what is the extent and source of this feature. Therefore, magnetic and gravity anomaly maps were made from the CHAMP geopotential data, measured at the current low altitude of 345-350 km over the northern Adriatic Sea. We made the magnetic anomaly map over this relatively small region using 36 descending and 85 ascending orbits screened to be at the lowest altitude and the most magnetically quietest data. We removed the main field component (i.e., IGRF-10 up to degree and order 13) and then demeaned individual tracks and subtracted a second order polynomial to remove regional and/or un-modeled external field features. The resulting map from these well-correlated anomalies revealed a positive magnetic anomaly (>2 nT). Reduction-to-the pole brought these CHAMP anomaly features into coincidence with the aeromagnetic data. Previously Cantini et al. (1999) compared the surface magnetic data with MAGSAT by continuing upward the former and downwards the latter to 100 km and found a good correlation for wavelengths of 300-500 km. We also investigated the CHAMP gravity data. They were reduced using the kinematic short-arc integration method (Ilk et al., 2005 and Mayer Gürr et al., 2005). However, no corresponding short-wavelength gravity anomaly was observed in our study area. This tectonically complex region is under horizontal stress and the source of the large magnetic anomaly can be modelled by an associated ophiolite melange.

  18. Studies of Geomagnetic Pulsations Using Magnetometer Data from the CHAMP Low-Earth-Orbit Satellite and Ground-Based Stations: a Review

    Directory of Open Access Journals (Sweden)

    P R Sutcliffe

    2011-06-01

    Full Text Available We review research on geomagnetic pulsations carried out using magnetic field measurements from the CHAMP low-Earth-orbit (LEO satellite and ground-based stations in South Africa and Hungary. The high quality magnetic field measurements from CHAMP made it possible to extract and clearly resolve Pi2 and Pc3 pulsations in LEO satellite data. Our analyses for nighttime Pi2 pulsations are indicative of a cavity mode resonance. However, observations of daytime Pi2 pulsation events identified in ground station data show no convincing evidence of their occurrence in CHAMP data. We also studied low-latitude Pc3 pulsations and found that different types of field line resonant structure occur, namely discrete frequencies driven by a narrow band source and L-dependent frequencies driven by a broad band source.

  19. Study of betatron oscillations in a constant field and alternating gradient accelerator; Etude des oscillations betatron dans l'accelerateur a champ fixe et a gradient alterne

    Energy Technology Data Exchange (ETDEWEB)

    Lauzanne, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    The conditions for the stability of a constant energy particle beam circulating in the magnetic field of the F.F.A.G. accelerator are studied. By a mathematical study it is possible to derive the equations for the equilibrium orbit and for the low amplitude oscillations, and the expressions for the amplitude stability limits of the beam. For this, approximation methods are used, in particular the linearization of the differential equations of the movement, and the method of gradual approximation. Numerical investigations carried out with the help of the IBM 7090 computer make it possible to judge the precision of the results given by the theory. A systematic variation of the parameters makes it possible to understand more clearly the mechanism of the amplitude variations of the trajectories. Finally, for the radial sector model, the possibility of introducing zones free from the magnetic field is considered. The case of short straight sections, respecting the field periodicity, and of that of long straight sections creating super-periods are considered. For the two cases are given solutions which should lead to a practical machine. (author) [French] On etudie les conditions de stabilite d'un faisceau de particules circulant a energie constante dans le champ magnetique de l'accelerateur F.F.A.G. Une etude mathematique permet d'etablir les equations de l'orbite d'equilibre et des oscillations de faible amplitude, les expressions des limites de stabilite en amplitude du faisceau. On emploie a cet effet des methodes d'approximation, essentiellement la linearisation des equations differentielles du mouvement et la methode de l'approximation douce. Des investigations numeriques effectuees a l'aide de la calculatrice IBM 7090 permettent d'apprecier l'exactitude des resultats fournis par la theorie. Une variation systematique des parametres permet de mieux comprendre le mecanisme des variations d'amplitude des trajectoires. On etudie enfin, pour le modele a secteur radial

  20. ULF wave activity during the 2003 Halloween superstorm: multipoint observations from CHAMP, Cluster and Geotail missions

    Directory of Open Access Journals (Sweden)

    G. Balasis

    2012-12-01

    Full Text Available We examine data from a topside ionosphere and two magnetospheric missions (CHAMP, Cluster and Geotail for signatures of ultra low frequency (ULF waves during the exceptional 2003 Halloween geospace magnetic storm, when Dst reached ~−380 nT. We use a suite of wavelet-based algorithms, which are a subset of a tool that is being developed for the analysis of multi-instrument multi-satellite and ground-based observations to identify ULF waves and investigate their properties. Starting from the region of topside ionosphere, we first present three clear and strong signatures of Pc3 ULF wave activity (frequency 15–100 mHz in CHAMP tracks. We then expand these three time intervals for purposes of comparison between CHAMP, Cluster and Geotail Pc3 observations but also to be able to search for Pc4–5 wave signatures (frequency 1–10 mHz into Cluster and Geotail measurements in order to have a more complete picture of the ULF wave occurrence during the storm. Due to the fast motion through field lines in a low Earth orbit (LEO we are able to reliably detect Pc3 (but not Pc4–5 waves from CHAMP. This is the first time, to our knowledge, that ULF wave observations from a topside ionosphere mission are compared to ULF wave observations from magnetospheric missions. Our study provides evidence for the occurrence of a number of prominent ULF wave events in the Pc3 and Pc4–5 bands during the storm and offers a platform to study the wave evolution from high altitudes to LEO. The ULF wave analysis methods presented here can be applied to observations from the upcoming Swarm multi-satellite mission of ESA, which is anticipated to enable joint studies with the Cluster mission.

  1. Juridicisation du champ journalistique et luttes pour la visibilité des journalistes pigistes

    Directory of Open Access Journals (Sweden)

    Faïza Naït-Bouda

    2014-04-01

    Full Text Available Véritable exception française d’un point de vue tant socioculturel que juridico-légal, les journalistes pigistes relèvent du régime salarial commun aux journalistes titularisés. En dépit de leur statut salarial et de subordonné prévu par la loi Cressard (1974, ils restent le plus souvent décrits comme freelance (ou indépendant et massifiés en cohorte de « précaires » condamnés au silence et à l’invisibilité ; représentation que le patronat de presse n’a pas manqué d’instrumentaliser sur le terrain juridique pour finir par lui donner un « effet de réalité ». Or, depuis peu, l’on assiste à un usage circulaire du droit dans la régulation des relations entre ces journalistes et leurs employeurs, chacune des parties recourant au droit sur un registre à la fois offensif et défensif. En effet, les journalistes pigistes tendent à user des mêmes « armes » qui ont conduit à leur stigmatisation et à ainsi convertir la contrainte en valeur mobilisatrice. Cet article entend déterminer la place du droit dans les stratégies de mise en visibilité et de reconnaissance que les journalistes pigistes déploient peu à peu. La procéduralisation du droit progressivement opérée par ces journalistes est questionnée à l’aune du processus de juridicisation des rapports sociaux, lequel traduit l’aspiration croissante des individus et des groupes à la reconnaissance sociale. Nous postulons que cet appel au droit participe d’un travail d’accession à l’« ordre du visible » engagé depuis peu par les journalistes pigistes de manière à gagner en visibilité et en reconnaissance au sein du champ journalistique et, plus largement, au sein de l’espace social. Couplé à la rhétorique de la précarité, catégorie largement plébiscitée par des discours publics empathiques pour caractériser une frange massifiée de la population, le recours au droit concèderait aux journalistes pigistes une entr

  2. Relation of zonal plasma drift and wind in the equatorial F region as derived from CHAMP observations

    Directory of Open Access Journals (Sweden)

    J. Park

    2013-06-01

    Full Text Available In this paper we estimate zonal plasma drift in the equatorial ionospheric F region without counting on ion drift meters. From June 2001 to June 2004 zonal plasma drift velocity is estimated from electron, neutral, and magnetic field observations of Challenging Mini-satellite Payload (CHAMP in the 09:00–20:00 LT sector. The estimated velocities are validated against ion drift measurements by the Republic of China Satellite-1/Ionospheric Plasma and Electrodynamics Instrument (ROCSAT-1/IPEI during the same period. The correlation between the CHAMP (altitude ~ 400 km estimates and ROCSAT-1 (altitude ~ 600 km observations is reasonably high (R ≈ 0.8. The slope of the linear regression is close to unity. However, the maximum westward drift and the westward-to-eastward reversal occur earlier for CHAMP estimates than for ROCSAT-1 measurements. In the equatorial F region both zonal wind and plasma drift have the same direction. Both generate vertical currents but with opposite signs. The wind effect (F region wind dynamo is generally larger in magnitude than the plasma drift effect (Pedersen current generated by vertical E field, thus determining the direction of the F region vertical current.

  3. Choroidal thickness and myopia in relation to physical activity - the CHAMPS Eye Study

    DEFF Research Database (Denmark)

    Lundberg, Kristian; Vestergaard, Anders Højslet; Jacobsen, Nina

    2018-01-01

    PURPOSE: To describe the relationship between choroidal thickness (CT) and myopia in relation to physical activity (PA) in a population-based child cohort. METHODS: In a prospective study of 307 children from the CHAMPS Study Denmark, we used objective data from GT3X accelerometer worn at four...

  4. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  5. EVALUATION DE L’IMPACT ENVIRONNEMENTAL : GeneSys-Colza : un modèle des effets à moyen et à long terme des systèmes de culture sur les flux de gènes entre champs de colza et repousses dans un espace agricole

    Directory of Open Access Journals (Sweden)

    Colbach Nathalie

    2000-07-01

    Full Text Available On a beaucoup parlé, lors de l’examen des demandes d’autorisation de mise en culture de variétés transgéniques de colza, des risques d’hybridation interspécifique du colza avec les crucifères sauvages, et d’introgression de transgènes dans les espèces adventices [1, 2]. Les flux de gènes intraspécifiques ont moins attiré l’attention du grand public; ils sont pourtant bien plus probables. Les transgènes peuvent être disséminés dans le temps, par l’intermédiaire de repousses de colza apparaissant dans les cultures suivant les variétés transgéniques, à cause de la perte d’une partie des graines produites par les cultures de colza avant ou pendant la récolte [3, 4], et dans l’espace, par l’intermédiaire de semences et de pollen disséminés par le vent ou d’autres vecteurs tels que les oiseaux ou les insectes [5-8]. Les semences dispersées peuvent produire directement des repousses de colza dans des champs voisins, tandis que le pollen peut transmettre le transgène en fécondant des plantes de colza présentes dans ces autres champs. Ce flux de gènes peut être à l’origine de différents problèmes tels que l’apparition de repousses de colza résistantes aux herbicides, difficiles à éliminer lorsqu’il s’agit d’un transgène de résistance à un herbicide, ou la pollution de récoltes de colza classique par le transgène, quelle que soit sa nature, et l’impossibilité d’écouler ces récoltes dans une filière « non-OGM ». Il est donc apparu nécessaire et urgent de mieux évaluer ce risque et d’identifier les moyens de le maîtriser. Les premiers éléments de réponse ont été donnés par les plates-formes « plantes transgéniques » des instituts techniques [9, 10]; cependant, ces plates-formes sont limitées dans le temps et l’espace et il n’est pas possible d’y rendre compte de la variabilité régionale des systèmes de culture et de leurs effets sur le devenir des

  6. Mediterranean studies of cardiovascular disease and hyperglycemia: analytical modeling of population socio-economic transitions (MedCHAMPS)--rationale and methods.

    Science.gov (United States)

    Maziak, Wasim; Critchley, Julia; Zaman, Shahaduz; Unwin, Nigel; Capewell, Simon; Bennett, Kathleen; Unal, Belgin; Husseini, Abdullatif; Romdhane, Habiba Ben; Phillimore, Peter

    2013-08-01

    In response to the escalating epidemic of cardiovascular disease (CVD) in the Mediterranean Region (MR), an international collaboration aiming at understanding the burden of CVD and evaluating cost-effective strategies to combat it was recently established. This paper describes the rationale and methods of the project MedCHAMPS to disseminate this successful experience. The framework of MedCHAMPS is exceptional in combining multiple disciplines (e.g. epidemiology, anthropology, economics), countries [Turkey, Syria, occupied Palestinian territory (oPt), Tunisia, UK, Ireland], research methods (situational and policy analysis, quantitative and qualitative studies, statistical modeling), and involving local stakeholders at all levels to assess trends of CVD/diabetes in the society and attributes of the local health care systems to provide optimal policy recommendations to reduce the burden of CVD/diabetes. MedCHAMPS provides policy makers in the MR and beyond needed guidance about the burden of CVD, and best cost-effective ways to combat it. Our approach of building developed-developing countries collaboration also provides a roadmap for other researchers seeking to build research base into CVD epidemiology and prevention in developing countries.

  7. Exemple d'imagerie de puits par diagraphie acoustique et sismique haute résolution An Example of Acoustics and Very High Resolution Seismic in a Highly Deviated Well

    OpenAIRE

    Mari J. L.; Gavin P.; Coppens F.

    2006-01-01

    La diagraphie acoustique est classiquement utilisée pour fournir la lenteur des formations. Les enregistrements en champ total obtenus dans des puits fortement déviés ou horizontaux peuvent être traités pour fournir des sections de microsismique de puits qui ont une investigation latérale d'une dizaine de mètres par rapport au drain. Cet article présente les résultats d'expérimentations réalisées dans une carrière calcaire située en Bourgogne (France). Un puits fortement dévié (10 degrés) a é...

  8. Study of the injection of plasma into a magnetic field of double curvature geometry; Etude de l'injection de plasma dans un champ magnetique a double courbure

    Energy Technology Data Exchange (ETDEWEB)

    Lasry, J [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-06-15

    An hydrogen plasma puff is injected along the lines of a magnetic field with a double curvature geometry. The plasma is produced by a coaxial gun with an annular preionization system. It is shown theoretically that the electric drift of the plasma can be cancelled if a depolarizing current flows along the field lines towards a region of good transverse conductivity. The experiment shows that in these conditions the curvature drift of the ions of the plasma may be used as a very efficient process to purify the fast component of the plasma puff. The depolarizing electron currents are measured and the mutual cancellation of the electric fields developing into the oppositely curved region is demonstrated to be possible. The current densities agree with the values deduced of the curvature drift of the ions. (author) [French] Un plasma d'hydrogene est injecte le long des lignes de force d'un champ magnetique a double courbure. Le plasma est produit par un canon coaxial a preionisation annulaire. Il est montre theoriquement que la derive electrique du plasma peut etre annulee si un courant de depolarisation circule le long des lignes de force vers une region de conductivite transversale elevee. L'experience montre que dans ces conditions, la derive de courbure des ions peut etre utilisee comme un moyen efficace de purification de la composante rapide du plasma. Les courants electroniques de depolarisation sont mesures et l'annulation mutuelle des champs electriques se developpant dans les regions de courbures opposees est demontree. Les densites de courant sont en accord avec les valeurs deduites de la derive de courbure des ions. (auteur)

  9. La pollution des sols des champs d’épandage d’eaux usées, contrainte et/ou ressource pour le développement durable en plaine de Bessancourt-Herblay-Pierrelaye

    Directory of Open Access Journals (Sweden)

    Vincent Mandinaud

    2005-11-01

    Full Text Available Historiquement affectés à l’assainissement des eaux usées brutes et à l’amendement des sols, les champs d’épandage de la ville de Paris, puis du SIAAP, sont au début de l’année 1997 en passe d’être publiquement reconnus pollués par des Eléments Traces Métalliques (ETM . Différentes opérations participent de ce double processus de reconsidération des risques associés à l’épandage et de requalification des entités territoriales concernées. La présentation dynamique des prises et des contraintes développées, en plaine de Bessancourt-Herblay-Pierrelaye singulièrement, permet de montrer comment la pollution des sols peut (réactiver localement une réflexion collective sur un développement territorial durable.

  10. The Design, Construction and Test of stray light suppression baffles for the CHAMP satellite

    DEFF Research Database (Denmark)

    Jørgensen, John Leif

    1997-01-01

    The Advanced Stellar Compass, to be delivered from IAU to the CHAMP project, requires some kind of stray-light suppressing shade to be mounted in front of the lens, in order to minimize the thermal impact and to maximize the performance envelope when subjected to non-stellar external light sources...

  11. Modélisation du champ magnétique d'un propulseur M.H.D. annulaire

    Science.gov (United States)

    Kom, C. H.; Brunet, Y.

    1995-01-01

    Stray fields have to be as small as possible to reduce the magnetic signature of the vessel in M.H.D. propulsion where the magnetic field has to be very high. The calculation of the magnetic field of an angular M.H.D. thruster is presented. The field is produced by a distribution of superconducting magnets in the shape of sectors. An analytical formulation of the field can be used in the active zone, outside the coil ends. An analytical method using a Fourier development of the current sheets is employed for an inductor in cylindrical sectors, and a direct method is used for a massive inductor. Numerical and analytical results are compared. Pour des raisons de discrétion, les champs de fuite doivent être minimisés en propulsion M.H.D. où les champs magnétiques doivent être intenses. Le calcul du champ magnétique d'un propulseur M.H.D. naval annulaire, constitué de secteurs inducteurs supraconducteurs est représenté. Dans la zone active, hors des têtes de bobines, une formulation analytique peut être utilisée. Une méthode analytique utilisant le développemment en série de Fourier du courant est adoptée pour les industeurs cylindriques, et une méthode directe pour les inducteurs massifs. Les résultats numériques sont comparés à ceux obtenus avec un logiciel d'éléments finis 2D.

  12. Development and Optical Testing of the Camera, Hand Lens, and Microscope Probe with Scannable Laser Spectroscopy (CHAMP-SLS)

    Science.gov (United States)

    Mungas, Greg S.; Gursel, Yekta; Sepulveda, Cesar A.; Anderson, Mark; La Baw, Clayton; Johnson, Kenneth R.; Deans, Matthew; Beegle, Luther; Boynton, John

    2008-01-01

    Conducting high resolution field microscopy with coupled laser spectroscopy that can be used to selectively analyze the surface chemistry of individual pixels in a scene is an enabling capability for next generation robotic and manned spaceflight missions, civil, and military applications. In the laboratory, we use a range of imaging and surface preparation tools that provide us with in-focus images, context imaging for identifying features that we want to investigate at high magnification, and surface-optical coupling that allows us to apply optical spectroscopic analysis techniques for analyzing surface chemistry particularly at high magnifications. The camera, hand lens, and microscope probe with scannable laser spectroscopy (CHAMP-SLS) is an imaging/spectroscopy instrument capable of imaging continuously from infinity down to high resolution microscopy (resolution of approx. 1 micron/pixel in a final camera format), the closer CHAMP-SLS is placed to a feature, the higher the resultant magnification. At hand lens to microscopic magnifications, the imaged scene can be selectively interrogated with point spectroscopic techniques such as Raman spectroscopy, microscopic Laser Induced Breakdown Spectroscopy (micro-LIBS), laser ablation mass-spectrometry, Fluorescence spectroscopy, and/or Reflectance spectroscopy. This paper summarizes the optical design, development, and testing of the CHAMP-SLS optics.

  13. Investigation of the Crust of the Pannonian Basin, Hungary Using Low-Altitude CHAMP Horizontal Gradient Magnetic Anomalies

    Science.gov (United States)

    Taylor, Patrick T.; Kis, Karoly I.; Puszta, Sandor; Wittmann, Geza; Kim, Hyung Rae; Toronyi, B.

    2011-01-01

    The Pannonian Basin is a deep intra-continental basin that formed as part of the Alpine orogeny. It is some 600 by 500 km in area and centered on Hungary. This area was chosen since it has one of the thinnest continental crusts in Europe and is the region of complex tectonic structures. In order to study the nature of the crustal basement we used the long-wavelength magnetic anomalies acquired by the CHAMP satellite. The SWARM constellation, scheduled to be launched next year, will have two lower altitude satellites flying abreast, with a separation of between ca. 150 to 200 km. to record the horizontal magnetic gradient. Since the CHAMP satellite has been in orbit for eight years and has obtained an extensive range of data, both vertically and horizontally there is a large enough data base to compute the horizontal magnetic gradients over the Pannonian Basin region using these many CHAMP orbits. We recomputed a satellite magnetic anomaly map, using the spherical-cap method of Haines (1985), the technique of Alsdorf et al. (1994) and from spherical harmonic coefficients of MF6 (Maus et aI., 2008) employing the latest and lowest altitude CHAMP data. We then computed the horizontal magnetic anomaly gradients (Kis and Puszta, 2006) in order to determine how these component data will improve our interpretation and to preview what the SW ARM mission will reveal with reference to the horizontal gradient anomalies. The gradient amplitude of an 1000 km northeast-southwest profile through our horizontal component anomaly map varied from 0 to 0.025 nT/km with twin positive anomalies (0.025 and 0.023 nT/km) separated by a sharp anomaly negative at o nT/km. Horizontal gradient indicate major magnetization boundaries in the crust (Dole and Jordan, 1978 and Cordell and Grauch, 1985). Our gradient anomaly was modeled with a twodimensional body and the anomaly, of some 200 km, correlates with a 200 km area of crustal thinning in the southwestern Pannonian Basin.

  14. 1986-IJBCS-Article-Hilaire Yaokokore

    African Journals Online (AJOL)

    hp

    Les oiseaux des champs de riz de la zone humide de Grand-Bassam ont été inventoriés de janvier. 2011 à février 2013 en vue de déterminer la composition et la dynamique des populations de l'avifaune de ces agroécosystèmes rizicoles. Les inventaires ornithologiques effectués dans les champs de riz par stade.

  15. AIMANTS PS CIRCUITS AUXILIAIRES DES PFW : UTILISATION DES PICK-UPS ET BOUCLES DE TOURS SELON LES TYPES DE CORRECTION

    CERN Document Server

    Ottaviani, J

    2005-01-01

    Les PFW sont des nappes polaires installées sur les pôles des aimants du PS. Elles sont au nombre de 4 par unité d’aimant et constituées d’un circuit principal (dans lequel circule le courant désiré selon le cycle magnétique utilisé) et de circuits auxiliaires. Les circuits auxiliaires sont des enroulements de correction (“pick-ups” brasés sur les enroulements principaux et boucles de tours). Pendant la variation du champ magnétique de l’aimant PS, on utilise des tensions induites dans ces circuits auxiliaires pour corriger les erreurs de champ dues aux pertes par courants de Foucault dans la chambre à vide. Les corrections à amener pour uniformiser le champ magnétique tout au long de la machine PS sont fonction des différents types de chambres à vide. A ce jour, nous utilisons 18 types de correction différents.

  16. Comparison of precision orbit derived density estimates for CHAMP and GRACE satellites

    Science.gov (United States)

    Fattig, Eric Dale

    Current atmospheric density models cannot adequately represent the density variations observed by satellites in Low Earth Orbit (LEO). Using an optimal orbit determination process, precision orbit ephemerides (POE) are used as measurement data to generate corrections to density values obtained from existing atmospheric models. Densities obtained using these corrections are then compared to density data derived from the onboard accelerometers of satellites, specifically the CHAMP and GRACE satellites. This comparison takes two forms, cross correlation analysis and root mean square analysis. The densities obtained from the POE method are nearly always superior to the empirical models, both in matching the trends observed by the accelerometer (cross correlation), and the magnitudes of the accelerometer derived density (root mean square). In addition, this method consistently produces better results than those achieved by the High Accuracy Satellite Drag Model (HASDM). For satellites orbiting Earth that pass through Earth's upper atmosphere, drag is the primary source of uncertainty in orbit determination and prediction. Variations in density, which are often not modeled or are inaccurately modeled, cause difficulty in properly calculating the drag acting on a satellite. These density variations are the result of many factors; however, the Sun is the main driver in upper atmospheric density changes. The Sun influences the densities in Earth's atmosphere through solar heating of the atmosphere, as well as through geomagnetic heating resulting from the solar wind. Data are examined for fourteen hour time spans between November 2004 and July 2009 for both the CHAMP and GRACE satellites. This data spans all available levels of solar and geomagnetic activity, which does not include data in the elevated and high solar activity bins due to the nature of the solar cycle. Density solutions are generated from corrections to five different baseline atmospheric models, as well as

  17. The design of coils for the production of high homogeneous fields; Calcul des bobinages pour la production de champs magnetiques tres homogenes

    Energy Technology Data Exchange (ETDEWEB)

    Desportes, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    The discovery of type II superconductors has considerably increased the possibilities of air-core coils, in particular with regard to the production of high homogeneous fields. The design of such magnets,calls for elaborate calculations which, in practise, can only be carried out on computers. The present report describes a complete set of programs for the calculation, in the case of cylindrical systems, of the magnetic field components at any point, the lines of flux, the forces, the self and mutual inductances, as well as the design of compensated coils for the production of high homogeneous fields. These programs have been employed for the calculation of two magnets which are described in detail. (author) [French] L'interet des bobines sans fer s'est considerablement accru depuis l'apparition recente des supraconducteurs de la deuxieme espece, en particulier pour la realisation d'aimants a champ tres homogene. Le calcul de tels bobinages fait appel a des methodes complexes dont l'execution pratique necessite l'emploi de machines a calculer. Le present rapport decrit un ensemble de programmes permettant de calculer, dans le cas de systemes de revolution de structure quelconque, le champ dans tout l'espace, les lignes de force du champ, les efforts electromagnetiques, les selfs et mutuelles, et de determiner des enroulements de compensation destines a uniformiser le champ. Ces programmes ont servi au calcul de deux aimants particuliers dont les caracteristiques detaillees sont fournies a titre d'application. (auteur)

  18. 103 L'exploitation des algues rouges Gelidium dans la région d'El ...

    African Journals Online (AJOL)

    PR BOKO

    L'algue rouge Gelidium forme le long de la côte atlantique marocaine des champs .... limité aux sites d'accès relativement facile par voie terrestre, c'est à dire l'axe situé .... de collecte en attendant le tonnage justifiant le transport par camion.

  19. [Antoine Béchamp and Victor Cornil Memento for Romanian pharmacy, chemistry and medicine].

    Science.gov (United States)

    Buiuc, D; Pânzaru, Carmen

    2008-01-01

    Today we commemorate a century from the death of two Romanian loving scientists: Antoine Béchamp (1816- March 31 1908), pharmacist, chemist and physician, professor at the Universities of Strasbourg, Montpellier and Lille, and Victor Cornil (1837- April 14 1908), physician, histopathologist and bacteriologist, professor of the University of Medicine in Paris, co-author with Victor Babeş on the first ever Bacteriological Treaty.

  20. Resistivity measurements using a direct current induction method (1963); Mesure de resistivite par la methode d'induction en courant continu (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Delaplace, J; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    toujours possible d'obtenir. Au contraire, la methode d'induction en courant continu que nous utilisons ne necessite aucun contact et s'applique tres bien aux echantillons de section importante. L'echantillon est place dans un champ magnetique uniforme; au moment ou l'on supprime le champ, des courants de Foucault, qui tendent a s'opposer a la disparition du champ, apparaissent dans l'echantillon. La loi de decroissance du flux magnetique dans l'echantillon permet de determiner la resistivite du materiau. Cette methode a ete appliquee a des echantillons de diametre compris entre 1 et 30 mm dans le cas de metaux bons conducteurs. Elle donne une valeur locale de la resistivite et permet d'en deceler toute variation le long d'un echantillon. Les mesures peuvent etre effectuees a toute temperature comprise entre quelques degres Kelvin et 500 deg. C. Nous avons utilise la methode d'induction pour suivre la purification du beryllium par fusion de zone: il est en effet possible d'evaluer la purete d'un materiau par des mesures de resistivite. Nous avons determine la valeur de la resistivite le long de chaque barreau de fusion de zone et localise ainsi la partie la plus pure. Des mesures a haute temperature ont ete faites sur le carbure d'uranium et sur des alliages fer-aluminium. Cette methode constitue un moyen d'investigation interessant de la resistivite des materiaux massifs. Sa precision et sa rapidite sont adaptees aussi bien aux etudes fondamentales qu'au controle de fabrication. (auteurs)

  1. Developpement d'un modele analytique pour l'analyse en elasticite lineaire de champs de deformation et contrainte au sein d'un polycristal. comparaison avec la methode des elements finis =

    Science.gov (United States)

    Bretin, Remy

    L'endommagement par fatigue des materiaux est un probleme courant dans de nombreux domaines, dont celui de l'aeronautique. Afin de prevenir la rupture par fatigue des materiaux il est necessaire de determiner leur duree de vie en fatigue. Malheureusement, dues aux nombreuses heterogeneites presentes, la duree de vie en fatigue peut fortement varier entre deux pieces identiques faites dans le meme materiau ayant subi les memes traitements. Il est donc necessaire de considerer ces heterogeneites dans nos modeles afin d'avoir une meilleure estimation de la duree de vie des materiaux. Comme premiere etape vers une meilleure consideration des heterogeneites dans nos modeles, une etude en elasticite lineaire de l'influence des orientations cristallographiques sur les champs de deformations et de contraintes dans un polycristal a ete realisee a l'aide de la methode des elements finis. Des correlations ont pu etre etablies a partir des resultats obtenus, et un modele analytique en elasticite lineaire prenant en compte les distributions d'orientations cristallographiques et les effets de voisinage a pu etre developpe. Ce modele repose sur les bases des modeles d'homogeneisation classique, comme le schema auto-coherent, et reprend aussi les principes de voisinage des automates cellulaires. En prenant pour reference les resultats des analyses elements finis, le modele analytique ici developpe a montre avoir une precision deux fois plus grande que le modele auto-coherent, quel que soit le materiau etudie.

  2. Characterization of CHAMP magnetic data anomalies: magnetic contamination and measurement timing

    International Nuclear Information System (INIS)

    Yin, Fan; Cai, Hongtao; Lühr, Hermann; Rauberg, Jan; Michaelis, Ingo

    2013-01-01

    The CHAMP (CHAllenging Minisatellite Payload) mission ended after more than ten years in space on 19 September 2010. For achieving a high measurement accuracy of the magnetometers on CHAMP, detailed analyses of spacecraft magnetic characteristics in orbit are required. A decade of continuous magnetometer and housekeeping data are a good basis for evaluating some of the effects of variable spacecraft magnetic fields on the ambient field determination. It was found that some perturbations of FGM (FluxGate vector Magnetometer) or OVM (OVerhauser scalar Magnetometer) measurements are caused by stray fields induced by the power system, the ASC (advanced stellar compass) instrument or magneto-torquer currents. The magnetic effect of solar currents on FGM measurements varies with the local time of the orbit and amounts to 0.2 nT. In cases when one head of the ASC instrument was blinded by the sun, sometimes transient drops in instrument current strength occur, which were accompanied by magnetic disturbance signals (∼0.3 nT) in FGM measurements. The magnetic residual contamination of OVM data by the torquer currents was of order 0.1 nT but still detectable. An improved torquer correction matrix is derived which eliminates this effect. In-flight scalar calibration parameters revealed some of the effects of timing anomalies. Time lags between FGM and OVM readings are misinterpreted by the scalar calibration as variations of the angles between some of the sensor axes. The resulting amplitudes of the anomalies presented here lie in the range of some 0.1 nT, but they are systematic in nature. (paper)

  3. Features of highly structured equatorial plasma irregularities deduced from CHAMP observations

    DEFF Research Database (Denmark)

    Xiong, C.; Luhr, H.; Ma, S. Y.

    2012-01-01

    In this study five years of CHAMP (Challenging Mini-satellite Payload) fluxgate magnetometer (FGM) data is used to investigate the characteristics of Equatorial Plasma Bubbles (EPBs). We filtered the FGM data by using bandpasses with four different cut-off periods to get the EPBs with different......). Since the height of the F-layer is highly correlated with the vertical plasma drift and solar flux, we sorted the ROCSAT-1 data into different groups by F10.7. From the integrated vertical drift we have estimated the post-sunset uplift of the ionosphere. By comparing the properties of EPB occurrence...

  4. Orbit error characteristic and distribution of TLE using CHAMP orbit data

    Science.gov (United States)

    Xu, Xiao-li; Xiong, Yong-qing

    2018-02-01

    Space object orbital covariance data is required for collision risk assessments, but publicly accessible two line element (TLE) data does not provide orbital error information. This paper compared historical TLE data and GPS precision ephemerides of CHAMP to assess TLE orbit accuracy from 2002 to 2008, inclusive. TLE error spatial variations with longitude and latitude were calculated to analyze error characteristics and distribution. The results indicate that TLE orbit data are systematically biased from the limited SGP4 model. The biases can reach the level of kilometers, and the sign and magnitude are correlate significantly with longitude.

  5. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.

    Science.gov (United States)

    Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

    2015-12-22

    The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves an active partition system composed of a nonspecific DNA-binding ATPase, ParA, and its stimulator protein ParB. The ParA/ParB system drives directed and persistent movement of DNA cargo both in vivo and in vitro. Filament-based models akin to actin/microtubule-driven motility were proposed for plasmid segregation mediated by ParA. Recent experiments challenge this view and suggest that ParA/ParB system motility is driven by a diffusion ratchet mechanism in which ParB-coated plasmid both creates and follows a ParA gradient on the nucleoid surface. However, the detailed mechanism of ParA/ParB-mediated directed and persistent movement remains unknown. Here, we develop a theoretical model describing ParA/ParB-mediated motility. We show that the ParA/ParB system can work as a Brownian ratchet, which effectively couples the ATPase-dependent cycling of ParA-nucleoid affinity to the motion of the ParB-bound cargo. Paradoxically, this resulting processive motion relies on quenching diffusive plasmid motion through a large number of transient ParA/ParB-mediated tethers to the nucleoid surface. Our work thus sheds light on an emergent phenomenon in which nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious solution shaped by evolution to cope with the lack of processive motor proteins in bacteria.

  6. Plasma Equilibrium in a Torus with High-Frequency Fields and Plasma Heating Resulting from the Development of a Powerful Beam of ''Escaping Electrons''; Plasma Torique: Stabilisation au Moyen de Champs de Haute Frequence et Chauffage par Formation d'un Flux Intense d'Electrons 'Emballes'; Ehksperimental'noe issledovanie ravnovesiya plazmy v tore pri nalichii vysokochastotnykh polej i nagreva plazmy za schet razvitiya moshchnogo puchka ''ubegayushchikh ehlektronov''; Equilibrio del Plasma en un Toro, en Presencia de Campos de Alta Frecuencia, y Calentamiento del Plasma por el Desarrollo de un Haz Potente de 'Electrones Desbocados '

    Energy Technology Data Exchange (ETDEWEB)

    Demirkhanov, R. A.; Kirov, A. G.; Stotland, M. A.; Malykh, N. I.; Horasanov, G. L.; Vishnevskij, N. K.; Gutkin, T. I.; Jampol' skij, I. R. [Fiziko-Tehnicheskij Institut Gosudarstvennogo Komiteta po Ispol' zovaniju Atomnoj Ehnergii SSSR, Sukhumi, SSSR (Russian Federation)

    1966-04-15

    electron temperature of the order of a few eV. When a rotating quadrupole high-frequency field is applied, the plasma is forced away from the walls and is localized in the centre with an increase in temperature. Attention was also paid to heating by a strong electric field in the absence of a rotating high-frequency quadrupole field. In this case, when the electric field is E{sub z} = 100 to 200 V cm{sup -}{sub 1}, a current Jp=3 to 5 kA is developed in the plasma; on being strongly damped, this current becomes essentially ohmic in character. At the same time the voltage in the bypass is very strongly damped in comparison with the inactive condition, which indicates effective absorption of the loop energy by the plasma. The energy absorbed by the plasma during the first half-cycle of the current, that is during about 1{mu}s, represents about 20 J, and the conductivity of the plasma is anomalously low. When heating is performed by a strong electric field, an intensive burst of X-radiation with an energy of the order of 100 keV is observed, together with the emission of.micro-wave noises at frequencies close to that of the plasma. (author) [French] Le memoire decrit les experiences qui ont ete effectuees dans l'installation RT-0. Cette installation est constituee par un tore ayant un grand diametre de 100 cm et un petit diametre de 10 cm. Le long de la chambre, il se forme un champ magnetique torique d'environ 6 kOe. L'ignition du plasma se fait sous une pression superieure ou egale a 5 x 10{sup -4} Torr au moyen d'un champ electrique longitudinal tournant (8,3 MHz). Au voisinage de la paroi de la chambre se trouve un champ quadripolaire de haute frequence (540 kHz), qui tourne autour du plus petit diametre, avec H{phi} = 200 Oe. Lorsque le banc de condensateurs a faible induction envoie une decharge dans les spires disposees le long du tore, il peut se creer a l'interieur de la chambre un champ electrique turbulent du type decroissant, ayant une intensite maximum E{sub z

  7. Physical activity and myopia in Danish children-The CHAMPS Eye Study

    DEFF Research Database (Denmark)

    Lundberg, Kristian; Suhr Thykjær, Anne; Søgaard Hansen, Rasmus

    2018-01-01

    PURPOSE: To determine associations between physical activity (PA) and myopia in Danish school children and investigate the prevalence of myopia. METHODS: This is a prospective study with longitudinal data on PA in a Danish child cohort. Physical activity (PA) was measured objectively by repeated....... The ophthalmologic examination was conducted at the mean age of 15.4 ± 0.7 years and included cycloplegic autorefraction and biometry. RESULTS: A total of 307 children participated in the Childhood Health, Activity, and Motor Performance School (CHAMPS) Eye Study. The cycloplegic spherical equivalent (SE) was 0...... PA and myopia, in this first of its kind study based on objective and repeated PA data....

  8. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  9. Schéma équivalent petit signal d\\'un transistor à effet de champ à ...

    African Journals Online (AJOL)

    Dans cet article, les auteurs présentent un schéma équivalent petit signal d\\'un transistor à effet de champ à base de nano tube de carbone (CNTFETs). Les éléments du schéma équivalent sont obtenus à partir de la mesure des paramètres « scattering » S du CNTFETs pour un point de polarisation dans une gamme de ...

  10. Émission spontanée amplifiée (ÉSA) dans une structure à double cavité verticale (Bi-VCSEL)

    Science.gov (United States)

    Boucher, Y.; Gayraud, L.

    2004-11-01

    Nous présentons une étude théorique de l'Émission Spontanée Amplifiée dans une structure verticale à double cavité, décrite en termes de couplage d'ondes. Chaque cavité y est représentée par un saut de phase, tandis que les puits quantiques sont assimilés à des singularités de Dirac de la permittivité. Les sources sont prises en compte dans le cadre du formalisme des matrices de transfert étendues (3 × 3), qui inclut la saturation des zones actives sous l'effet du champ interne. Dans le plan spectral, celui-ci apparaît, au même titre que le champ émis, filtré par la fonction de transfert bimode de la structure.

  11. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Science.gov (United States)

    Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

    2015-01-01

    Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  12. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  13. Systematic study of the use of electrical fields for improving heat exchange in boiling liquids; Etude systematique de l'utilisation de champs electriques pour l'amelioration des echanges thermiques dans des liquides bouillants

    Energy Technology Data Exchange (ETDEWEB)

    Bochirol, L; Bonjour, E; Lagnier, R; Verdier, J; Weil, L [Commissariat a l' Energie Atomique, Grenoble (France).Centre d' Etudes Nucleaires

    1961-07-01

    We have studied, at the boiling point, for liquids with various electrical properties (hexane, benzene, trichloroethylene, demineralized water, acetone, methyl-ethyl-ketone, etc...) the effect of the application of electric fields on the exchange coefficients and on the maximum dissipative powers before calefaction. We have given the mechanism of the significant improvements obtained (multiplication by a factor of 2 to 10): - in the natural convection zone by showing the role played by the dielectric properties of the liquids under study; - in the zone of nuclear boiling by analysis of the forces acting on the boiling nuclei. Finally we give some experimental results concerning measurements made under pressure until local boiling occurred: they show the possibility of some interesting applications of the method. (author) [French] On a etudie, a l'ebullition, sur des liquides de caracteristiques electriques diverses (hexane, benzene, trichlorethylene, eau demineralisee, acetone, methylethylcetone, etc...) les effets de l'application de champs electriques sur les coefficients d'echanges et les puissances maximales dissipables avant calefaction. On a precise le mecanisme des ameliorations importantes obtenues (multiplication par un facteur 2 a 10): - dans la zone de convection naturelle en mettant en evidence le role des caracteristiques dielectriques des liquides etudies; - dans la zone d'ebullition nucleaire par analyse des forces mises en jeu sur les noyaux d'ebullition. On donne enfin des resultats experimentaux sur des mesures effectuees sous pression jusqu'a l'ebullition locale: ils illustrent des possibilites d'applications interessantes du procede. (auteur)

  14. De la philosophie des concours littéraires au Burkina Faso | Sanou ...

    African Journals Online (AJOL)

    Au Burkina Faso, c'est l'Etat, à travers l'administration culturelle, qui s'est substitué aux initiatives privées, individuelles et/ou collectives par sa participation à la mise en place du champ littéraire. Sa politique s'est essentiellement concentrée sur les concours littéraires dont la philosophie est guidée par l'encouragement des ...

  15. 1254-IJBCS-Article-Moussa Gibigaye

    African Journals Online (AJOL)

    hp

    Une étude par enquête de type micro-économique et de type agronomique auprès des paysans et par observations sur les champs a été conduite dans la Commune de Malanville pour comprendre les facteurs qui influencent l'adoption de la culture attelée. Les résultats montrent que la culture attelée est l'un des facteurs ...

  16. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation

    Science.gov (United States)

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta

    2016-01-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces. To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  17. Nathalie BOULOUCH, Lumière, la couleur inventée. les autochromes, collection privée de la famille Lumière, préf. de M. Trarieux-Lumière, trad. anglaise par P. Hargreaves, Lyon, A. Scheibli, 1995, non pag., 48 ill. coul., bibl.

    OpenAIRE

    Aubenas, Sylvie

    2002-01-01

    Le propos de cet ouvrage est de faire connaître l'usage privé que firent les frères Lumière, industriels lyonnais et par ailleurs inventeurs du cinéma, de leur création favorite: l'autochrome. C'est un album de famille charmant qui déroule sous nos yeux la douce vie d'avant 1914: scènes champêtres, baignades dans une mer encore déserte, bébés joufflus et jeux d'enfants, jeunes femmes en dentelles et ombrelles. Le tout présenté de façon particulièrement soignée: exceptionnelle qualité de...

  18. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  19. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  20. 2500-IJBCS-Article-Dr Neya Bouma James

    African Journals Online (AJOL)

    hp

    DANIDA) et l'Organisation Africaine de la Propriété Intellectuelle (OAPI) pour leurs soutiens financiers. RESUME. Un champ ensemencé avec des ...... interne et externe par l'adoption de mesures comme l'utilisation de semences saines, le.

  1. Comparaison de deux techniques d'identification des souches de levures de vinification basées sur le polymorphisme de l'ADN génomique: réaction de polymérisation en chaine (PCR et analyse des caryotypes (électrophorèse en champ pulsé

    Directory of Open Access Journals (Sweden)

    Isabelle Masneuf-Pomarède

    1994-06-01

    Full Text Available Une nouvelle technique de la biologie moléculaire, la réaction de polymérisation en chaine (PCR permet l'identification des souches de levures de vinification. Mise en oeuvre directement sur levures entières, elle permet d'obtenir des profils variables selon les souches, par l'amplification de séquences d'ADN génomique. Utilisée sur lies, la PCR constitue un outil rapide et sensible pour le contrôle d'implantation des levains en vinification. Cependant le pouvoir discriminant de la PCR est inférieur à celui de l'électrophorèse en champ pulsé pour la caractérisation des souches de levures indigènes. Elle doit être considérée comme une technique complémentaire d'identification des souches de S. cerevisiae.

  2. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  3. In-flight Quality and Accuracy of Attitude Measurements from the CHAMP Advanced Stellar Compass

    DEFF Research Database (Denmark)

    Jørgensen, Peter Siegbjørn; Jørgensen, John Leif; Denver, Troelz

    2005-01-01

    The German geo-observations satellite CHAMP carries highly accurate vector instruments. The orientation of these relative to the inertial reference frame is obtained using star trackers. These advanced stellar compasses (ASC) are fully autonomous units, which provide, in real time, the absolute...... attitude with accuracy in the arc second range. In order to investigate the in-flight accuracy of the ASC, the terminology to characterize noise and biases is introduced. Relative instrument accuracy (RIA) and absolute instrument accuracy (AIA) can in principle be determined in-flight. However problems...

  4. A study of the fluorescence of the rare gases excited by nuclear particles. Use of the principle for the detection of nuclear radiation by scintillation; Etude de la fluorescence des gaz rares excites par des particules nucleaires. Utilisation pour la detection des rayonnements nucleaires par scintillation

    Energy Technology Data Exchange (ETDEWEB)

    Koch, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-12-15

    composantes, l'une tres breve due a la desexcitation directe du gaz rare, l'autre relativement plus lente, due au transfert d'energie sur les impuretes. La mesure des durees de vie des etats excites a confirme l'hypothese precedente, la partie breve de l'impulsion est extremement courte: inferieure a 2,25.10{sup -9} s dans le cas du xenon, la partie plus lente a une duree qui depend etroitement de la concentration d'azote, l'azote etant l'impurete dont le role est preponderant dans tous les cas. L'etude des gaz rares soumis a un champ electrique a permis de montrer que la quantite de lumiere produite par une particule {alpha} peut etre multipliee (par 60 dans un champ de 600 V/cm par exemple) ce qui correspond a un rendement de luminescence superieur a celui de INa TI. Dans la deuxieme partie on a etudie les caracteristiques des gaz rares comme scintillateurs, la plus importante est l'absence de saturation de la fluorescence lorsque la densite d'excitation transmise au gaz devient tres grande. Ceci joint au temps de scintillation tres court a permis d'etudier un certain nombre d'applications a la physique nucleaire (mesure d'energie des particules lourdes, etude cinetique des reacteurs nucleaires, spectroscopie des neutrons...). (auteur)

  5. Parálisis cerebral :

    OpenAIRE

    Cabrero Izquierdo, María del Carmen

    2012-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  6. Power dissipated - or generated - by the various excited modes in a plasma; Puissance dissipee - ou generee - par les differents modes excites dans un plasma

    Energy Technology Data Exchange (ETDEWEB)

    Rolland, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The energy exchange between a plasma and a source of excitation J(r)sin(w{sub 0}t) is investigated. In order to include the case of growing waves associated with connective instabilities, this problem is treated in the context of the wave-packet theory, by writing the field as a double integral in two complex planes. the paths of the integration are defined after a separation into two classes of the root k(w) of the dispersion equation. We find that - at even in the absence of collisions - there is still a power exchange exchange, due to the spatial dispersion. Thus a connexion can be established with the kinematic theories of growing waves [1][2] and the modes generating power can be found. Moreover, the power dissipated by spatial dispersion is found to be critical with that due to Landau's effect for long waves. This confirms the kinematic character of the latter and bridges a gap between macroscopic and microscopic theories. (author) [French] On etudie les echanges d'energie entre un plasma et une source d'excitation J(r)sin(w{sub 0}t). Pour inclure le cas des ondes croissantes associees aux instabilites convectives, on traite ce probleme dans le cadre de la theorie du paquet d'ondes en definissant le champ par une integrale double dans deux plans complexes; les parcours d'integration sont precises apres avoir separe en deux classes les racines k(w) de l'equation de dispersion. On trouve que meme en l'absence de collisions, la puissance echangee n'est pas nulle, a cause de la dispersion spatiale. Ceci permet d'etablir une connexion avec les theories cinematiques des ondes croissantes [1][2], tout en precisant quels sont les modes generateurs d'energie. Par ailleurs, la puissance dissipee par dispersion spatiale se revele identique a la dissipation par effet Landau pour les grandes ondes, ce qui confirme le caractere cinematique de ce dernier et fait la jonction entre les theories microscopique et macroscopique. (auteur)

  7. Magnetic properties of CHAMP and their effects on in-orbit calibration

    Directory of Open Access Journals (Sweden)

    H. Lühr

    2013-03-01

    Full Text Available CHAMP has so far been the most successful magnetic field mission. For achieving that, special effort had to be invested in building a magnetically clean spacecraft. The magnetic moment of the spacecraft is about 1 Am2. In this article we introduce a new method that allows the determination of the magnetic moment during the mission from the average current strength of the magneto-torquers. In order to achieve precise field vector data, the readings of the fluxgate magnetometer are routinely calibrated against the absolute Overhauser measurements. A reanalysis of all the magnetic field data is performed which takes also into account small disturbances from the power system. Uncertainties of the final magnetic field data are estimated to be of the order of 0.1 nT.

  8. Estudio de las observaciones de tropopausa sobre el cono sur de Sudamérica mediante GPS a bordo de los satélites SAC-C y CHAMP Tropopause observation study over southern South America using GPS data from SAC-C and CHAMP satellites

    Directory of Open Access Journals (Sweden)

    S. Gabriela Lakkis

    2006-12-01

    Full Text Available En este trabajo se analiza la validez de la técnica de radio ocultación satelital (GPS llevada a cabo por los satélites SAC-C y CHAMP en tres estaciones chilenas y cuatro argentinas, como referencia del Cono Sur, durante el período 2001-2003. La validez de la técnica se discute por medio de la comparación de los parámetros atmosféricos obtenidos a partir de los satélites con los valores de radiosondeo. Una vez validada la ocultación para las latitudes estudiadas, en función de los datos satelitales se calcula temperatura, presión y altura de la tropopausa, así como valores de presión de vapor de agua y su comportamiento. De los resultados obtenidos del trabajo surge que las ocultaciones arrojan valores que se ajustan muy bien a los tradicionales radiosondeos, especialmente en la zona atmosférica comprendida entre superficie y los 10 kilómetros. De los registros satelitales se estimó que la tropopausa extratropical entre las longitudes 80° S y 60° S presenta valores de temperatura que fluctúan entre los 204 y los 222 K para el Hemisferio Sur hasta el trópico de Capricornio, con una altura mínima de 9 kilómetros y una máxima de 15.3 kilómetros. Para los valores de presión de vapor de agua se observó un comportamiento fuertemente decreciente a medida que se asciende desde la troposfera, hasta llegar a la estabilización en la estratosfera una vez atravesada la tropopausa, donde la variable presenta un cambio en la tasa de variación.Validation of radio occultation technique by Global Positioning System (GPS, carried out on board the SAC-C and CHAMP satellites, is analyzed over three stations of Chile and four for Argentine, as a reference for South America during 2001-2003. The discussion is based on the statistical comparison of the data of GPS with data from nearby radiosonde measurements. Though the occultation concept for obtaining profiles of atmospheric parameters, data derived from GPS, were used to calculate

  9. 1985-IJBCS-Article-Abdou Laouali

    African Journals Online (AJOL)

    hp

    exploitées sans tenir compte de leur abondance ni de leur taux de régénération, ce qui les menace de .... champs, à l'abri des regards. Les auteurs de cette pratique sont généralement des sculpteurs qui ... 8(3): 1065-1074, 2014. 1069 le bois mort sans être inquiétés par la loi. Ces paysans justifient leurs actes par le fait ...

  10. Construction of an apparatus for nuclear orientation measurements at low temperatures. Application to neodymium-cobalt alloy; Realisation d'un appareil pour des mesures d'orientation nucleaire a basse temperature. Application a l'alliage neodyme-cobalt

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, E [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-10-01

    We describe experiments along which has been studied the anisotropy of {gamma} radiations emitted by oriented nuclei. We have used the great hyperfine fields acting on nuclei in ferromagnetic metals so as to produce alignment at low temperature. By irradiation we obtained a few cobalt 60 nuclei in our samples which were then cooled down to 0,01 K. The anisotropic rate of the 1,33 MeV {gamma} radiation was measured in function of the sample temperature, using as thermometer the anisotropy of {gamma} radiation emitted by cobalt 60 nuclei in a cobalt single crystal. Cobalt 60 was lined up in a cobalt nickel alloy (40% Ni). The hyperfine field at the cobalt was measured compared to the effective field in metallic cobalt: Heff(Co Ni)/Heff(Co metal) = 0.71 {+-} 0.12. These results are in good agreement with specific heat measurements made previously. Cobalt 60 has been polarised in a neodymium-cobalt alloy (NdCo{sub 5}). The field at the cobalt in NdCo{sub 5} has been measured compared to the field in metallic cobalt and taking the non-saturation into account we found 165000 oersteds < Heff(NdCo{sub 5}) < 220000 oersteds. (author) [French] Nous decrivons des experiences au cours desquelles nous avons etudie l'anisotropie de rayonnements {gamma} emis par des noyaux orientes. Nous avons utilise les grands champs hyperfins agissant sur las noyaux dans les metaux ferromagnetiques pour produire l'alignement a basse temperature. Par irradiation nous avons obtenu quelques noyaux de cobalt 60 dans nos echantillons qui furent ensuite refroidis a 0,01 K. Le degre d'anisotropie du rayonnement {gamma} de 1,33 MeV fut mesure en fonction de la temperature de l'echantillon en utilisant l'anisotropie du rayonnement {gamma} de noyaux de cobalt 60 dans un monocristal de cobalt metallique utilise comme thermometre. Le cobalt 60 a ete aligne dans un alliage de cobalt-nickel (40% Ni). Le champ hyperfin au niveau du cobalt a ete mesure par rapport au champ effectif dans le cobalt metallique

  11. Study of beam-plasma interactions in the presence of a magnetic field; Etude d'interactions faisceau-plasma en la presence d'un champ magnetique

    Energy Technology Data Exchange (ETDEWEB)

    Etievant, C [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1963-12-15

    The instabilities developing in a 'beam-plasma' system and in a 'double-beam' system in the presence of a magnetic field are discussed theoretically starting from the conductivity tensor expression for a multi-beam system. Oblique propagation is taken into account and this leads to the introduction of certain instability mechanisms which would not appear in the case of a propagation which is purely parallel or perpendicular to the magnetic field. Two experiments are described: a) Study of the collision of two counterstreaming electron beams: An instability has been observed experimentally which leads to the generation of a stationary cyclotron wave having a frequency of {omega}{sub ce}/2. A description is given of the measurement of the interaction frequency, of the wavelength and of the build-up time of the wave. b) Study of a 'beam-plasma' system: A description is given of the measurement of the spectra of excited waves and of the perturbation of the beam velocity distribution at the plasma-exit. This perturbation is very pronounced when 'plasma-plasma' interaction appears in the system. A study into cyclotron oscillations produced in the plasma by excitation due to the passage of the beam is also described in this report. (author) [French] Les instabilites se developpant dans un systeme 'faisceau-plasma' et dans un systeme 'faisceau-faisceau' en la presence d'un champ magnetique sont discutees theoriquement a partir de l'expression du tenseur de conductivite d'un systeme multi-faisceaux. La propagation oblique est prise en consideration, ce qui introduit certains mecanismes d'instabilite qui n'apparaitraient pas pour une propagation purement parallele ou perpendiculaire au champ magnetique. Deux experiences sont decrites: a) Etude de la collision de deux faisceaux d'electrons: Une instabilite conduisant a la generation d'une onde cyclotronique stationnaire a la frequence {omega}{sub ce}/2 a ete observee experimentalement. Les mesures de la frequence d

  12. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

    Science.gov (United States)

    Cunningham, Margaret R; McIntosh, Kathryn A; Pediani, John D; Robben, Joris; Cooke, Alexandra E; Nilsson, Mary; Gould, Gwyn W; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

    2012-05-11

    Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to be sustained. Unlike other PAR subtypes, the mechanisms regulating receptor trafficking of PAR(4) remain unknown. Here, we report novel features of the intracellular trafficking of PAR(4) to the plasma membrane. PAR(4) was poorly expressed at the plasma membrane and largely retained in the endoplasmic reticulum (ER) in a complex with the COPI protein subunit β-COP1. Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR → A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4). Interestingly, co-expression with PAR(2) facilitated plasma membrane delivery of PAR(4), an effect produced through disruption of β-COP1 binding and facilitation of interaction with the chaperone protein 14-3-3ζ. Intermolecular FRET studies confirmed heterodimerization between PAR(2) and PAR(4). PAR(2) also enhanced glycosylation of PAR(4) and activation of PAR(4) signaling. Our results identify a novel regulatory role for PAR(2) in the anterograde traffic of PAR(4). PAR(2) was shown to both facilitate and abrogate protein interactions with PAR(4), impacting upon receptor localization and cell signal transduction. This work is likely to impact markedly upon the understanding of the receptor pharmacology of PAR(4) in normal physiology and disease.

  13. Efficacité d'un exutoire de dévalaison pour smolts de saumon atlantique (Salmo salar L. et comportement des poissons au niveau de l'aménagement hydroélectrique de Bedous sur le gave d'Aspe étudiés par la technique de marquage-recapture et par radiotélémétrie

    Directory of Open Access Journals (Sweden)

    CHANSEAU M.

    1999-04-01

    Full Text Available Deux expérimentations ont été conduites en 1995 et 1998 au niveau de la prise d'eau de l'aménagement hydroélectrique de Bedous sur le Gave d'Aspe afin de tester l'efficacité d'un exutoire de dévalaison pour smolts de saumon atlantique (Salmo salar L.. Le dispositif de dévalaison est situé en rive droite à proximité immédiate du plan des grilles. Le débit moyen alimentant l'exutoire a varié au cours de l'étude de 0,4 m3/s à 1,2 m3/s ce qui correspond à 1,6 % à 4,3 % du débit turbiné. Lefficacité du dispositif a été évaluée grâce à la technique de marquage-recapture. Le comportement des smolts dans le canal d'amenée a été suivi par radiotélémétrie. L'efficacité de l'exutoire (moyenne : 17 % s'est révélée très faible en 1995 â cause de conditions hydrauliques défavorables. Un mur déflecteur a été mis en place en 1997 afin de modifier l'écoulement dans le canal et améliorer le guidage des poissons vers l'entrée du dispositif de dévalaison. L'efficacité de l'exutoire est passée à 55 %. Le comportement des poissons à l'amont immédiat des grilles de prise d'eau est très dépendant des conditions hydrodynamiques dans le canal d'amenée. L'efficacité de l'exutoire semble croître avec la longueur des poissons, la proportion des classes de taille inférieures à 19 cm étant plus faible sur les poissons piégés que sur les poissons lâchés. Cette sélection est très certainement liée à l'espacement relativement important des barreaux des grilles de la prise d'eau (30 mm qui malgré le courant tangentiel au plan de grilles demeurent plus perméables aux individus les plus petits. L'éclairage de l'entrée de l'exutoire ne paraît pas avoir d'influence sur les déplacements des poissons radiomarqués dans le canal d'amenée, le facteur hydraulique étant prépondérant. Il modifie cependant les rythmes de passage des poissons par l'exutoire.

  14. Les «États point-champ» phéniciens et l’empire carthaginois dans l’espace méditerranéen (IXe-IIe siècles avant J.-C.

    Directory of Open Access Journals (Sweden)

    Philippe Moyen

    2006-03-01

    Full Text Available De la prospérité des cités-États phéniciennes à la disparition de l’empire carthaginois, la Méditerranée, entre le IXe et le IIe siècle, constitue un champ d’analyse privilégié pour étudier, dans la longue durée, l’évolution des «États point-champ» et mettre en évidence la diversité des modalités de territorialisation dans la production des aires géopolitiques supports de la trame évènementielle de l’Histoire.

  15. 2805-IJBCS-Article-Eliasse Dieme

    African Journals Online (AJOL)

    hp

    Contamination des céréales par l'aflatoxine en Afrique : revue des méthodes de lutte existantes ..... pratiques de gestion agricole qui augmentent les rendements des cultures ... technologie de contrôle au champ de l'aflatoxine est utilisée au ...

  16. Effects Of HIV stigma reduction interventions in diasporic communities: insights from the CHAMP study.

    Science.gov (United States)

    Li, Alan Tai-Wai; Fung, Kenneth Po-Lun; Maticka-Tyndale, Eleanor; Wong, Josephine Pui-Hing

    2018-06-01

    Racialized diasporic communities in Canada experience disproportionate burden of HIV infection. Their increased vulnerabilities are associated with interlocking challenges, including barriers in accessing resources, migration and settlement stress, and systemic exclusion. Further, people living with HIV (PLHIV) in these diasporic communities face stigma and discrimination in both mainstream Canadian society as well as their own ethno-racial communities. HIV stigma negatively impacts all aspects of HIV care, from testing to disclosure to treatment and ongoing care. In response to these challenges, a Toronto based community organization developed and implemented the CHAMP project to engage people living with HIV/AIDS (PLHIV) and leaders from different service sectors from the African/Caribbean, Asian and Latino communities to explore challenges and strategies to reduce HIV stigma and build community resilience. The study engaged 66 PLHIV and ethno-racial leaders from faith, media and social justice sectors in two stigma-reduction training programs: Acceptance Commitment Therapy Training (ACT) and Social Justice Capacity Building (SJCB). Data collection included pre-and post- intervention surveys, focus groups and monthly activity logs. Participants were followed for a year and data on changes in the participants' attitudes and behaviors as well as their actual engagement in HIV prevention, PLHIV support and stigma reduction activities were collected. CHAMP results showed that the interventions were effective in reducing HIV stigma and increasing participants' readiness to take action towards positive social change. Participants' activity logs over a period of 9 months after completing the training showed they had engaged in 1090 championship activities to advocate for HIV related health equity and social justice issues affecting racialized and newcomer PLHIV and communities.

  17. Average thermospheric wind patterns over the polar regions, as observed by CHAMP

    Directory of Open Access Journals (Sweden)

    H. Lühr

    2007-06-01

    Full Text Available Measurements of the CHAMP accelerometer are utilized to investigate the average thermospheric wind distribution in the polar regions at altitudes around 400 km. This study puts special emphasis on the seasonal differences in the wind patterns. For this purpose 131 days centered on the June solstice of 2003 are considered. Within that period CHAMP's orbit is precessing once through all local times. The cross-track wind estimates of all 2030 passes are used to construct mean wind vectors for 918 equal-area cells. These bin averages are presented in corrected geomagnetic coordinates. Both hemispheres are considered simultaneously providing summer and winter responses for the same prevailing geophysical conditions. The period under study is characterized by high magnetic activity (Kp=4− but moderate solar flux level (F10.7=124. Our analysis reveals clear wind features in the summer (Northern Hemisphere. Over the polar cap there is a fast day-to-night flow with mean speeds surpassing 600 m/s in the dawn sector. At auroral latitudes we find strong westward zonal winds on the dawn side. On the dusk side, however, an anti-cyclonic vortex is forming. The dawn/dusk asymmetry is attributed to the combined action of Coriolis and centrifugal forces. Along the auroral oval the sunward streaming plasma causes a stagnation of the day-to-night wind. This effect is particularly clear on the dusk side. On the dawn side it is evident only from midnight to 06:00 MLT. The winter (Southern Hemisphere reveals similar wind features, but they are less well ordered. The mean day-to-night wind over the polar cap is weaker by about 35%. Otherwise, the seasonal differences are mainly confined to the dayside (06:00–18:00 MLT. In addition, the larger offset between geographic and geomagnetic pole in the south also causes hemispheric differences of the thermospheric wind distribution.

  18. Average thermospheric wind patterns over the polar regions, as observed by CHAMP

    Directory of Open Access Journals (Sweden)

    H. Lühr

    2007-06-01

    Full Text Available Measurements of the CHAMP accelerometer are utilized to investigate the average thermospheric wind distribution in the polar regions at altitudes around 400 km. This study puts special emphasis on the seasonal differences in the wind patterns. For this purpose 131 days centered on the June solstice of 2003 are considered. Within that period CHAMP's orbit is precessing once through all local times. The cross-track wind estimates of all 2030 passes are used to construct mean wind vectors for 918 equal-area cells. These bin averages are presented in corrected geomagnetic coordinates. Both hemispheres are considered simultaneously providing summer and winter responses for the same prevailing geophysical conditions. The period under study is characterized by high magnetic activity (Kp=4− but moderate solar flux level (F10.7=124. Our analysis reveals clear wind features in the summer (Northern Hemisphere. Over the polar cap there is a fast day-to-night flow with mean speeds surpassing 600 m/s in the dawn sector. At auroral latitudes we find strong westward zonal winds on the dawn side. On the dusk side, however, an anti-cyclonic vortex is forming. The dawn/dusk asymmetry is attributed to the combined action of Coriolis and centrifugal forces. Along the auroral oval the sunward streaming plasma causes a stagnation of the day-to-night wind. This effect is particularly clear on the dusk side. On the dawn side it is evident only from midnight to 06:00 MLT. The winter (Southern Hemisphere reveals similar wind features, but they are less well ordered. The mean day-to-night wind over the polar cap is weaker by about 35%. Otherwise, the seasonal differences are mainly confined to the dayside (06:00–18:00 MLT. In addition, the larger offset between geographic and geomagnetic pole in the south also causes hemispheric differences of the thermospheric wind distribution.

  19. General problems arising from the analogical resolution of the kinetic equations of nuclear reactors (1961); Problemes generaux poses par la resolution analogique des equations cinetiques des reacteurs nucleaires (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Caillet, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The author reviews precisely the analogical techniques used for the resolution of the kinetic equations of nuclear reactors. Prior to this, he recalls the reasons which oblige physicians and engineers, even today, to use electronic machines in this domain. The author then considers the technological problems posed by the range of values which the various nuclear parameters adopt. In each case, he shows that a compromise is possible allowing an optimum precision. He compares the results to those obtained by arithmetic calculation and uses the examples chosen in a critical analysis of the present possibilities of the two methods of calculation. (author) [French] L'auteur cherche a faire un point aussi exact que possible des techniques analogiques utilisees pour resoudre les equations cinetiques des reacteurs nucleaires. Il rappelle auparavant les raisons pour lesquelles physiciens et ingenieurs sont obliges, encore aujourd'hui, de faire appel aux machines electroniques dans ce domaine. Puis il etudie les problemes technologiques que souleve le champ des valeurs prises par les differents parametres nucleaires. Dans chacun des cas, il montre l'existence d'un compromis qui permet d'atteindre une precision optimum. Il compare les resultats obtenus a ceux provenant de calculateurs arithmetiques et profite des exemples choisis pour faire une analyse critique des possibilites actuelles offertes par les deux modes de calcul. (auteur)

  20. Superconducting transition and low-field magnetoresistance of a niobium single crystal at 4.2 deg. K; Transition supraconductrice et magnetoresistance en champ faible d'un echantillon monocristallin de niobium a 4.2 deg. K

    Energy Technology Data Exchange (ETDEWEB)

    Perriot, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Service de physique du solide et de resonnance magnetique

    1967-01-01

    We report the study of the electrical resistance of a niobium single crystal, at 4.2 deg. K, from the beginning of the superconductive transition to 80 kilo oersteds. Critical fieldsH{sub c2} and H{sub c3} have been determined. Influences on superconductive transition of current density, field-current angle, crystal orientation and magnetoresistance have been studied. Variation laws of low-field transverse and longitudinal magneto-resistances have been determined. (author) [French] La variation de la resistance electrique d'un monocristal cylindrique de niobium a ete etudiee, a 4,2 deg. K, depuis le debut de la transition supraconductrice jusqu'a 80 kilooersteds. Les champs critiques H{sub c2} et H{sub c3} ont ete determines. On a etudie l'influence de la densite de courant, de l'angle champ-courant, de l'anisotropie cristalline et de la magnetoresistance sur la transition supraconductrice. Les lois de variation des magnetoresistances transversale et longitudinale ont ete determinees dans le domaine des champs faibles. (auteur)

  1. Interpretation of CHAMP Magnetic Anomaly Data over the Pannonian Basin Region Using Lower Altitude Horizontal Gradient Data

    Science.gov (United States)

    Taylor, P. T.; Kis, K. I.; Wittmann, G.

    2013-01-01

    The ESA SWARM mission will have three earth orbiting magnetometer bearing satellites one in a high orbit and two side-by-side in lower orbits. These latter satellites will record a horizontal magnetic gradient. In order to determine how we can use these gradient measurements for interpretation of large geologic units we used ten years of CHAMP data to compute a horizontal gradient map over a section of southeastern Europe with our goal to interpret these data over the Pannonian Basin of Hungary.

  2. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-12-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  3. On the capability of Swarm for surface mass variation monitoring: Quantitative assessment based on orbit information from CHAMP, GRACE and GOCE

    Science.gov (United States)

    Baur, Oliver; Weigelt, Matthias; Zehentner, Norbert; Mayer-Gürr, Torsten; Jäggi, Adrian

    2014-05-01

    In the last decade, temporal variations of the gravity field from GRACE observations have become one of the most ubiquitous and valuable sources of information for geophysical and environmental studies. In the context of global climate change, mass balance of the Arctic and Antarctic ice sheets gained particular attention. Because GRACE has outlived its predicted lifetime by several years already, it is very likely that a gap between GRACE and its successor GRACE follow-on (supposed to be launched in 2017, at the earliest) occurs. The Swarm mission - launched on November 22, 2013 - is the most promising candidate to bridge this potential gap, i.e., to directly acquire large-scale mass variation information on the Earth's surface in case of a gap between the present GRACE and the upcoming GRACE follow-on projects. Although the magnetometry mission Swarm has not been designed for gravity field purposes, its three satellites have the characteristics for such an endeavor: (i) low, near-circular and near-polar orbits, (ii) precise positioning with high-quality GNSS receivers, (iii) on-board accelerometers to measure the influence of non-gravitational forces. Hence, from an orbit analysis point of view the Swarm satellites are comparable to the CHAMP, GRACE and GOCE spacecraft. Indeed and as data analysis from CHAMP has been shown, the detection of annual signals and trends from orbit analysis is possible for long-wavelength features of the gravity field, although the accuracy associated with the inter-satellite GRACE measurements cannot be reached. We assess the capability of the (non-dedicated) mission Swarm for mass variation detection in a real-case environment (opposed to simulation studies). For this purpose, we "approximate" the Swarm scenario by the GRACE+CHAMP and GRACE+GOCE constellations. In a first step, kinematic orbits of the individual satellites are derived from GNSS observations. From these orbits, we compute monthly combined GRACE+CHAMP and GRACE

  4. Case report

    African Journals Online (AJOL)

    abp

    12 sept. 2013 ... La biologie a montré une anémie à 7,2 g/dl et un bilan d'hémostase correcte. Un tamponnement vaginal a été réalisé par la mise d'un champ tétra dans le vagin après administration de morphine et la patiente a été transfusée par 4 culots globulaires. Le taux d'hémoglobine après transfusion a demeuré ...

  5. Aspects of higher spin Hamiltonian dynamics: Conformal geometry, duality and charges

    OpenAIRE

    Leonard, Amaury

    2017-01-01

    Nous avons investigué les propriétés des champs de jauge de spin élevé libres à travers une étude de divers aspects de leur dynamique hamiltonienne. Pour des champs se propageant sur un espace-temps plat, les contraintes issues de l'analyse hamiltonienne de ces théories de jauge ont été identifiées et résolues par l'introduction de prépotentiels, dont l'invariance de jauge comprend, de façon intrigante, à la fois des difféomorphismes linéarisés généralisés et des transformations d'échelle de ...

  6. Combining human and machine processes (CHAMP)

    Science.gov (United States)

    Sudit, Moises; Sudit, David; Hirsch, Michael

    2015-05-01

    Machine Reasoning and Intelligence is usually done in a vacuum, without consultation of the ultimate decision-maker. The late consideration of the human cognitive process causes some major problems in the use of automated systems to provide reliable and actionable information that users can trust and depend to make the best Course-of-Action (COA). On the other hand, if automated systems are created exclusively based on human cognition, then there is a danger of developing systems that don't push the barrier of technology and are mainly done for the comfort level of selected subject matter experts (SMEs). Our approach to combining human and machine processes (CHAMP) is based on the notion of developing optimal strategies for where, when, how, and which human intelligence should be injected within a machine reasoning and intelligence process. This combination is based on the criteria of improving the quality of the output of the automated process while maintaining the required computational efficiency for a COA to be actuated in timely fashion. This research addresses the following problem areas: • Providing consistency within a mission: Injection of human reasoning and intelligence within the reliability and temporal needs of a mission to attain situational awareness, impact assessment, and COA development. • Supporting the incorporation of data that is uncertain, incomplete, imprecise and contradictory (UIIC): Development of mathematical models to suggest the insertion of a cognitive process within a machine reasoning and intelligent system so as to minimize UIIC concerns. • Developing systems that include humans in the loop whose performance can be analyzed and understood to provide feedback to the sensors.

  7. Long-term analysis of ionospheric polar patches based on CHAMP TEC data

    DEFF Research Database (Denmark)

    Noja, M.; Stolle, Claudia; Park, J.

    2013-01-01

    Total electron content (TEC) from LEO satellites offers great possibility to sound the upper ionosphere and plasmasphere. This paper describes a method to derive absolute TEC observations aboard CHAMP considering multipath effects and receiver differential code bias. The long-term data set of 9...... years GPS observations is used to investigate the climatological behavior of high-latitude plasma patches in both hemispheres. The occurrence of polar patches has a clear correlation with the solar cycle, which is less pronounced in the Southern Hemisphere (SH). Summed over all years, we observed...... a higher number of patches in the SH. The maximum occurrence rate of patches has been found at the dayside polar cusp during 12:00-18:00 MLT (magnetic local time) supporting the mechanisms for patch creation by local particle precipitation and by intrusion of subauroral plasma into the polar cap through...

  8. Reduction of fields between co-axial cylinders by means of interposed screens; L'abaissement des champs entre cylindres coaxiaux au moyen d'ecrans intercales

    Energy Technology Data Exchange (ETDEWEB)

    Bernard, J; Bruck, H; Prevot, F

    1950-05-01

    The dielectric rigidity of the space between two coaxial cylinders at a given potential can be increased by interposing coaxial cylindrical screens (the method of C. M. Turner, Thesis, Univ. of Wisconsin, 1943). The combination of screens reducing the maximum value of a simple field between two cylinders is calculated as a function of number of screens, their radius, and their potential, and, for a given number of screens, the optimum radii and potentials for maximum field reduction are determined. [French] La rigidite dielectrique de l'espace compris entre deux cylindres coaxiaux, portes a des potentiels donnes, peut etre augmentee en intercalant des ecrans cylindriques coaxiaux (methode de C.M. Turner). En fonction de leur nombre, de leur rayon et de leur potentiel, on calcule de combien ces ecrans permettent de reduire la valeur du champ regnant primitivement entre les deux cylindres, et, pour un nombre d'ecrans donne, on determine les valeurs optima de leur rayon et potentiel, correspondant a la reduction maximum des champs. (auteur)

  9. De l’interdisciplinaire comme paradigme de recherche.

    Directory of Open Access Journals (Sweden)

    Eduardo Camacho-Hübner

    2007-12-01

    Full Text Available © Peter Fischli, David Weiss, “Outlaws” (from Quiet Afternoon/Équilibres , 1984, Photograph. Courtesy Galerie Eva Presenhuber, Zurich ( Image commentée par Véronique Mauron, Historienne de l’art. Chercher à développer un champ de recherche spécifique par le biais du rapprochement entre deux disciplines territoriales, la géomatique 1 et la morphologie urbaine, semble à première vue tout à fait indiqué pour élaborer un terrain interdisciplinaire. Tel est le contexte de ...

  10. Utilisation d'un microfiltre tangentiel en oenologie

    Directory of Open Access Journals (Sweden)

    Michel Serrano

    1984-06-01

    Full Text Available A pilot tangential filter made by the Societe I D E and 4 different membranes were tested in a cooperative winery in the Gironde during the 1983 crush. The apparatus can produce, from a must or wine high in suspended solids, a liquid brillantly clear, sterile, and heat (protein stable. However, certain membranes profoundly modified the macromolecular stucture of wines (polysaccharides and polyphenols and the organoleptic character of red wines.

  11. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  12. Effets Seebeck et Nernst dans les cuprates: Etude de la reconstruction de la surface de Fermi sous champ magnetique intense

    Science.gov (United States)

    Laliberte, Francis

    2010-06-01

    Ce memoire presente des mesures de transport thermoelectrique, les effets Seebeck et Nernst, dans une serie d'echantillons de supraconducteurs a haute temperature critique. Des resultats obtenus recemment au Laboratoire National des Champs Magnetiques Intenses a Grenoble sur La1.7Eu0.2Sr0.1 CuO4, La1.675Eu0.2Sr0.125CuO 4, La1.64Eu0.2Sr0.16CuO4, La1.74Eu0.1Sr0.16CuO4 et La 1.4Nd0.4Sr0.2CuO4 sont analyses. Une attention particuliere est accordee aux equations de la theorie semi-classique du transport et leur validite est verifiee. La procedure experimentale et les materiaux utilises pour concevoir les montages de mesures sont expliques en detail. Enfin, un chapitre est dedie a l'explication et l'interpretation des resultats de transport thermoelectrique sur YBa2Cu3O6+delta publies au cours de l'hiver 2010 dans les revues Nature et Physical Review Letters. Les donnees d'effet Seebeck dans les echantillons de La 1.8-x,Eu0.2SrxCuO 4, ou un changement de signe est observe, permettent de conclure a la presence d'une poche d'electrons dans la surface de Fermi qui domine le transport a basse temperature dans la region sous-dopee du diagramme de phase. Cette conclusion est similaire a celle obtenue par des mesures d'effet Hall dans YBa 2Cu3O6+delta et elle cadre bien dans un scenario de reconstruction de la surface de Fermi. Les donnees d'effet Nernst recueillies indiquent que la contribution des fluctuations supraconductrices est limitee a un modeste intervalle de temperature au-dessus de la temperature critique.

  13. CM5, a pre-Swarm comprehensive geomagnetic field model derived from over 12 yr of CHAMP, Ørsted, SAC-C and observatory data

    DEFF Research Database (Denmark)

    Sabaka, Terence J.; Olsen, Nils; Tyler, Robert H.

    2015-01-01

    A comprehensive magnetic field model named CM5 has been derived from CHAMP, Orsted and SAC-C satellite and observatory hourly-means data from 2000 August to 2013 January using the Swarm Level-2 Comprehensive Inversion (CI) algorithm. Swarm is a recently launched constellation of three satellites ...

  14. Globalização e poder de estado: circulação internacional de elites e hierarquias do campo jurídico brasileiro

    Directory of Open Access Journals (Sweden)

    Fabiano Engelmann

    2012-01-01

    Full Text Available Prenant comme point de départ la problématique de la mondialisation des travaux d'experts concernant l'État, on examine les conditions d'internationalisation du champ juridique brésilien visant surtout le rapport entre le capital international mobilisé par les juristes et la hiérarchisation dans ce champ. Cette analyse part surtout de la comparaison des trajectoires universitaires, professionnelles et politiques de trois segments représentatifs de l'élite juridique: enseignants dans les cours de doctorat en droit, avocats associés aux plus importants cabinets juridiques et ministres du Supérieur Tribunal de Justice et du Supérieur Tribunal Fédéral. Les divers liens avec l'espace international peuvent être rapportés aux différentes positions dans le champ juridique brésilien et à leur relation avec l'espace politique et économique.

  15. Superconducting transition and low-field magnetoresistance of a niobium single crystal at 4.2 deg. K; Transition supraconductrice et magnetoresistance en champ faible d'un echantillon monocristallin de niobium a 4.2 deg. K

    Energy Technology Data Exchange (ETDEWEB)

    Perriot, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Service de physique du solide et de resonnance magnetique

    1967-01-01

    We report the study of the electrical resistance of a niobium single crystal, at 4.2 deg. K, from the beginning of the superconductive transition to 80 kilo oersteds. Critical fieldsH{sub c2} and H{sub c3} have been determined. Influences on superconductive transition of current density, field-current angle, crystal orientation and magnetoresistance have been studied. Variation laws of low-field transverse and longitudinal magneto-resistances have been determined. (author) [French] La variation de la resistance electrique d'un monocristal cylindrique de niobium a ete etudiee, a 4,2 deg. K, depuis le debut de la transition supraconductrice jusqu'a 80 kilooersteds. Les champs critiques H{sub c2} et H{sub c3} ont ete determines. On a etudie l'influence de la densite de courant, de l'angle champ-courant, de l'anisotropie cristalline et de la magnetoresistance sur la transition supraconductrice. Les lois de variation des magnetoresistances transversale et longitudinale ont ete determinees dans le domaine des champs faibles. (auteur)

  16. Characteristics of the plasma injected into D.E.C.A. 2; Caracteristiques du plasma injecte dans D.E.C.A. 2

    Energy Technology Data Exchange (ETDEWEB)

    Lecoustey, P; Luc, H; Tachon, J; Veron, D [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1963-07-01

    Deuterium plasma is injected from an electrode-less plasma gun along the lines of force of a static magnetic field. This field is constant over length of 1 m; it increases thereafter in a 10 to 1 ratio over a 4 meter length up to the chamber where the measurements are carried out. Density measurements are performed using Faraday cups and an 8.6 mm microwave interferometer. For instance in a 1600 G magnetic field a 0.5 x 10{sup 13} deutons/cm{sup 3} density arises for a plasma with velocity 3 x 10{sup 7} cm/s. The transverse energy is first determined from the diamagnetic signal amplitude of magnetic loops. The main results are obtained from the study of plasma transmitted through a magnetic barrier by means of measurements made with a Faraday cup, magnetic loops and thermocouples. The results given by these different methods are in good agreement and allow to define for the whole of the plasma flow a mean < {theta} > value for the ions pitch angle. In a 1600 G, < {theta} > equal 32 degrees; i.e. mean transverse energy of 360 eV for a plasma with a 030 eV longitudinal energy (a velocity equal to 3 x 10{sup 7} cm/s). The high value of the transverse energy might be attributed to a pre-compression in the field gradient. Preliminary measurements seem to indicate the possibility of trapping the plasma between two magnetic barriers. (authors) [French] Un plasma de deuterium est injecte par un canon a induction parallelement aux lignes de force d'un champ magnetique statique, constant sur une longueur de 1 m et ensuite croissant dans un rapport 10 a 1 sur une longueur de 4 m, jusque dans la chambre ou sont effectuees les mesures. La densite est determinee par des mesures d'interferometrie hertzienne et au moyen de cylindres de Faraday. Par exemple dans un champ de 1600 G on trouve une densite de 0,5 x 10{sup 13} deutons/cm{sup 3} pour un plasma anime d'une vitesse de 3 x 10{sup 7} cm/s. Une premiere determination de l'energie transversale est faite a partir des signaux

  17. Equatorial Kelvin Waves Observed with GPS Occultation Measurements : CHAMP and SAC-C (2.Space-Borne GPS Meteorology and Related Techniques)

    OpenAIRE

    Ho-Fang, TSAI; Toshitaka, TSUDA; George A., HAJJ; Jens, WICKERT; Yuichi, AOYAMA; Radio Science Center for Space and Atmosphere (RASC), Kyoto University :National Space Program Office(NSPO); Radio Science Center for Space and Atmosphere (RASC), Kyoto University; Jet Propulsion Laboratory (JPL), California Institute of Technology; GeoForschungsZentrum Potsdam (GFZ), Department 1:Geodesy and Remote Sensing; RASC, Kyoto University

    2004-01-01

    Structure and propagation of equatorial Kelvin waves during May 2001 and December 2002 are observed from the temperature profiles in the upper troposphere and the lower stratosphere using CHAMP and SAC-C GPS radio occultation data. Kelvin waves derived from temperature fluctuations characterize eastward phase propagation in time-longitude section and eastward phase tilts with height in altitude-longitude section between 10 and 30 km. The phase progression spans the range indicating the contin...

  18. The Relationship of High-Latitude Thermospheric Wind With Ionospheric Horizontal Current, as Observed by CHAMP Satellite

    Science.gov (United States)

    Huang, Tao; Lühr, Hermann; Wang, Hui; Xiong, Chao

    2017-12-01

    The relationship between high-latitude ionospheric currents (Hall current and field-aligned current) and thermospheric wind is investigated. The 2-D patterns of horizontal wind and equivalent current in the Northern Hemisphere derived from the CHAMP satellite are considered for the first time simultaneously. The equivalent currents show strong dependences on both interplanetary magnetic field (IMF) By and Bz components. However, IMF By orientation is more important in controlling the wind velocity patterns. The duskside wind vortex as well as the antisunward wind in the morning polar cap is more evident for positive By. To better understand their spatial relation in different sectors, a systematic superposed epoch analysis is applied. Our results show that in the dusk sector, the vectors of the zonal wind and equivalent current are anticorrelated, and both of them form a vortical flow pattern for different activity levels. The currents and zonal wind are intensified with the increase of merging electric field. However, on the dawnside, where the relation is less clear, antisunward zonal winds dominate. Plasma drift seems to play a less important role for the wind than neutral forces in this sector. In the noon sector, the best anticorrelation between equivalent current and wind is observed for a positive IMF By component and it is less obvious for negative By. A clear seasonal effect with current intensities increasing from winter to summer is observed in the noon sector. Different from the currents, the zonal wind intensity shows little dependence on seasons. Our results indicate that the plasma drift and the neutral forces are of comparable influence on the zonal wind at CHAMP altitude in the noon sector.

  19. Nuclear magnetic resonance at 310 MHz in a superconducting solenoid; Resonance magnetique nucleaire a 310 MHz dans un solenoide supra-conducteur

    Energy Technology Data Exchange (ETDEWEB)

    Dunand, J J [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1970-07-01

    The realisation of an NMR spectrometer with a superconducting magnet is presented in the first section. The methods to attain the best possible homogeneity of the magnetic field and to minimize the error in the spectrometer are described. The second section is devoted to the study of elastomers and nitr-oxides free radicals. A shift of the transition temperature with the magnetic field appears for the elastomers. The increasing paramagnetic shift has allowed a complete study by NMR of piperidinic and pyrrolidinic nitroxide free radicals. (author) [French] Dans la premiere partie est exposee la realisation d'un spectrometre de RMN utilisant un solenoide supraconducteur. Des solutions sont donnees pour obtenir la meilleure homogeneite possible du champ magnetique et pour minimiser les sources d'erreur apportees par le spectrometre. La deuxieme partie est consacree a l'etude d'elastomeres et de radicaux libres nitroxydes. Une variation de la temperature de transition avec le champ magnetique est mise en evidence pour les elastomeres. L'accroissement du deplacement paramagnetique a permis une etude complete par RMN des radicaux libres nitroxydes piperidiniques et pyrrolidiniques. (auteur)

  20. Mécanismes d'écoulement des charges à la surface des polymères granulaires

    Directory of Open Access Journals (Sweden)

    M. Kachi

    2014-09-01

    Full Text Available Les forces électriques s’exerçant sur des polymères granulaires chargés sont mises à profit dans plusieurs processus électrostatiques. La dynamique de charges de surface de ces matériaux est très importante pour ce type de processus. Le but de ce papier est d’analyser l’écoulement des charges à la surface de couches compactes de polymères granulaires, en interprétant les mesures sans contact réalisées par trois sondes de potentiel, de champ et de charge, ayant chacune une taille différente. Des mesures du profile de potentiel à différents instants sont également réalisées afin d’expliquer les différences entre les vitesses de déclin de potentiel, de champ et de charge mesurées par les trois sondes. Les résultats mettent en évidence un écoulement transversal et longitudinal de la charge surfacique.

  1. Bibenligne

    Directory of Open Access Journals (Sweden)

    Véronique Ginouvès

    2012-07-01

    Full Text Available http://www.bibenligne.org La rubrique Bibenligne propose une sélection de sites web qui concerne le champ couvert par la remmm et présente un intérêt scientifique ou documentaire. Cette rubrique est alimentée par les concepteurs et rédacteurs du site Bibenligne, sélection raisonnée de catalogues de bibliothèques et de centres documentaires en sciences humaines et sociales. African Women Bibliographic Database http://www.bibenligne.org/index379.html African Women Bibliographic Database donne a...

  2. La forme de l’espace, des trous noirs à l’Univers chiffonné

    CERN Multimedia

    CERN. Geneva

    2006-01-01

    Trous noirs, forme de l’Univers, structure de l’espace-temps… Décrire la forme de notre espace a toujours mis en jeu de nombreux modèles géométriques, chacun impliquant une théorie physique sous-jacente. L'un des grands défis de la physique fondamentale du XXIe siècle est de visualiser la distorsion de l’espace-temps, engendrée par les champs gravitationnels et quantiques. La conférence sera illustrée par de spectaculaires animations issues de simulations d'ordinateur.

  3. Motor performance as predictor of physical activity in children - The CHAMPS Study-DK

    DEFF Research Database (Denmark)

    Larsen, Lisbeth Runge; Kristensen, Peter Lund; Junge, Tina

    , health-related fitness and performance-related fitness were significantly associated to time spent at moderate to vigorous physical activity level at three years follow up. The clinical relevance of the results indicated cardiorespiratory fitness and shuttle run to be important skills to perceive......Background Physical activity is associated to several health benefits in children and has a tendency to track from childhood to adulthood. An adequate motor performance has been shown positively related to physical activity level in cross sectional studies and may be the foundation of a healthy...... lifestyle, but there is a lack of longitudinal studies. The objective of this study was to explore the longitudinal relationship between motor performance and physical activity in a three-year follow up study. Methods Longitudinal analyses were performed using data from the CHAMPS-Study DK, including 673...

  4. Modélisation par éléments finis 3D du champ magnétostatique dans les enroulements des réactances cuirassées de grande puissance. Comparaison avec le calcul en 2D

    Science.gov (United States)

    Ngnegueu, Triomphant; Terme, Claude; Mailhot, Michel

    1993-03-01

    In this paper, the finite element method is applied for the computation of the magnetostatic field in the windings of a shell-form reactor. The modeling is carried out in 3D, using FLUX3D, a software developed at the Laboratoire d'Electrotechnique de Grenoble. The results are compared to those obtained in 2D. These calculation results are also compared to some test results. Dans cet article, nous décrivons une application de la méthode des éléments finis pour la modélisation du champ magnétostatique dans les enroulements d'une réactance cuirassée de grande puissance. La modélisation est conduite en 3D, en utilisant le logiciel FLUX3D. Les résultats du calcul sont comparés avec ceux obtenus en 2D. Quelques comparaisons sont aussi effectuées avec des résultats de mesure.

  5. 644-IJBCS-Article-Dr Thiery B C Alavo

    African Journals Online (AJOL)

    DR GATSING

    Ce criquet était abondant dans le champ et se nourrit des feuilles de H. suaveolens. Les jeunes plants étaient complètement détruits par ce ravageur qui consomme entièrement toutes les premières feuilles et le bourgeon terminal. Anomis (Cosmophila) flava (Lepidoptera: Noctuidae). Les chenilles de cette espèce se.

  6. 2183-IJBCS-Article-Bouet Alphonse

    African Journals Online (AJOL)

    hp

    Short Communication http://indexmedicus.afro.who.int. Impact de la surveillance humaine sur les dégâts d'oiseaux en riziculture pluviale. Alphonse BOUET 1* ..... dès le lever du soleil pour rejoindre leurs refuges après le coucher du soleil. Il faut par ailleurs une ressource humaine suffisante pour mieux quadriller le champ.

  7. La médecine du tri: histoire, éthique, anthropologie

    NARCIS (Netherlands)

    Lachenal, G.; Lefève, C.; Nguyen, V.K.

    2014-01-01

    Qui soigner d’abord quand les ressources manquent ? Qui faire attendre ? Quels principes éthiques et quels critères médicaux utiliser pour classer les patients par ordre de priorité ? Opération fondamentale mise au point sur les champs de bataille, le « triage » est devenu, dans l’humanitaire et les

  8. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  9. Properties of traveling atmospheric disturbances (TADs) inferred from CHAMP accelerometer observations

    Science.gov (United States)

    Bruinsma, Sean L.; Forbes, Jeffrey M.

    2009-02-01

    Densities derived from accelerometer measurements on the CHAMP satellite near 400 km are used to statistically establish characteristics of large-scale (>1000 km) traveling atmospheric disturbances (TADs). Only TADs that at least propagate from the auroral zone to the equator are analyzed here, and a total of 21 identifiable events are found over the years 2001 2007. The average speed of all TADs, regardless of local time, is 646 ± 122 ms-1. The average speeds on the dayside and nightside are 595 ± 127 ms-1 and 685 ± 106 ms-1, respectively, i.e., the speed appears to be 10% higher on average on the nightside. On six occasions TADs were only detected on the night side; however, TADs on the dayside often appear more distinctly in the data. Moreover, contrary to some theoretical expectations, dayside TADs do not dissipate more readily than night side TADs, although much less are detected between 8 20 solar local time. No clear dependence of TAD amplitude or phase speed with respect to Kp, or rate of increase of Kp, is found.

  10. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  11. Colonna, Fanny, Récits de la province égyptienne. Une ethnographie sud/sud, Sinbad, Actes Sud, 2004, 486 p.

    Directory of Open Access Journals (Sweden)

    Emma Aubin-Boltanski

    2006-03-01

    Full Text Available Cet ouvrage s’inscrit dans un champ frontalier, à la fois littérature de déambulation et sociologie. Il est constitué par une longue série d’entretiens illustrés par des photographies en noir et blanc et s’achève par un « point de vue sociologique » d’une dizaine de pages. L’enquête s’est déroulée entre 1996 et 1997 dans la province égyptienne avec l’objectif de comprendre comment on y vit, comment on y pense et ainsi combler un vide dans la recherche qui s’intéresse peu aux marges. Dans le d...

  12. Grégory DERVILLE (2017), Le pouvoir des médias

    OpenAIRE

    Ben Youssef, Imen

    2018-01-01

    Dans son ouvrage, Grégory Derville s’intéresse au pouvoir des médias ainsi qu’aux rapports entre le champ politique et les médias. Les sociétés occidentales ont connu au cours des dernières décennies la montée en puissance des médias. Celle-ci se manifeste par l’engouement des ménages pour l’acquisition de nouveaux appareils de communication, par la forte consommation des programmes télévisés ainsi que par la hausse de fréquentation des sites Web et des réseaux numériques. Ces bouleversements...

  13. Étude des matrices sol-gel en film mince par détection de molécule unique en champ large : diffusion moléculaire et agrégation photo-induite

    Science.gov (United States)

    Nutarelli, D.; Débarre, A.; Jaffiol, R.; Julien, C.; Richard, A.; Tchénio, P.; Chaput, F.; Boilot, J. P.

    2004-11-01

    La fluorescence de molécules de colorant dans des matrices sol-gel en film mince a été étudiée par détection de molécule unique. Outre les phénomènes de photo-blanchiment et de clignotement, un processus de photo-agrégation a été observé. Ce phénomène, dont la dynamique dépend de la présence d'oxygène, de l'intensité du laser d'excitation et de la température, montre l'existence de deux classes de molécules dans l'échantillon. Des molécules immobiles et d'autres qui diffusent. L'analyse de la dynamique d'agrégation permettra de dégager certaines caractéristiques du mécanisme de photo-agrégation et d'appréhender le rôle joué par la matrice sol-gel dans ce processus.

  14. Contribution to the analysis of light elements using x fluorescence excited by radio-elements; Contribution a l'analyse des elements legers par fluorescence x excitee au moyen de radioelements

    Energy Technology Data Exchange (ETDEWEB)

    Robert, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    In order to study the possibilities of using radioactive sources for the X-fluorescence analysis of light elements, the principle is given, after a brief description of X-fluorescence, of the excitation of this phenomenon by X, {beta} and {alpha} emission from radio-elements. The operation and use of the proportional gas counter for X-ray detection is described. A device has been studied for analysing the elements of the 2. and 3. periods of the Mendeleev table. It makes it possible to excite the fluorescence with a radioactive source emitting X-rays or a particles; the X-ray fluorescence penetrates into a window-less proportional counter, this being made possible by the use of an auxiliary electric field in the neighbourhood of the sample. The gas detection pressure leading to the maximum detection yield is given. The spectra are given for the K{sub {alpha}} lines of 3. period elements excited by {sup 55}Fe, {sup 3}H/Zr and {sup 210}Po sources; for the 2. period the K{sub {alpha}} spectra of carbon and of fluorine excited by the {alpha} particles of {sup 210}Po. (author) [French] Afin d'etudier les possibilites d'emploi de sources radioactives a l'analyse par fluorescence X des elements legers, on presente apres rappel de notions generales sur la fluorescence X, le principe de l'excitation de ce phenomene par emission X, {beta}, {alpha} de radioelements. Le fonctionnement et l'utilisation du compteur proportionnel a gaz a la detection du rayonnement X est developpe. Un dispositif permettant l'analyse des elements des 2eme et 3eme periodes de la classification de Mendeleev est etudie. Il permet l'excitation de la fluorescence par source radioactive emettrice de rayons X ou de particules {alpha}; le rayonnement X de fluorescence penetre dans un compteur proportionnel depourvu de fenetre, ceci est rendu possible en creant un champ electrique auxiliaire au voisinage de l'echantillon. On definit une pression du gaz de detection pour un rendement de detection maximal

  15. Experimental study of superconductivity induced by proximity effects; Etude experimentale de la supraconductivite induite par effets de proximite

    Energy Technology Data Exchange (ETDEWEB)

    Martinet, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-11-15

    We present a study of the proximity effects between a superconductor (InBi or PbBi alloys) and a 'normal' metal (Zn or Sn respectively, above their critical temperature) using essentially the tunneling techniques. On the N side, some specific properties of such an induced superconductivity are described: linear variation of the pair potential near the critical temperature of the binary layer, T{sub CNS}; reduced energy scale at T{sub CNS}; evidence of a thermodynamic critical field (called breakdown field) presented by N above its critical temperature. On the S side, we study crossing from a gapless to a quasi gapless regime. This gives a proof of a finite coherence length at T{sub CNS}. Experimental details (in particular about the preparation and measurement of tunneling junctions) are given in annexe. Possible applications are suggested. (author) [French] Nous presentons une etude experimentale des effets de proximite entre un supraconducteur (alliages d'InBi ou de PbBi) et un metal 'normal' (Zn ou Sn respectivement, pris au-dessus de leur temperature critique), en utilisant principalement des mesures d'effet tunnel. Du cote N, on met en evidence des proprietes specifiques de cette supraconductivite induite: comportement lineaire du potentiel de paires pres de la temperature critique du bilame, T{sub CNS}; echelle d'energie reduite a T{sub CNS}; apparition d'un champ critique thermodynamique (appele champ de basculement) dans N au-dessus de sa temperature critique. Du cote S, nous etudions le passage continu d'une situation 'sans bande interdite' a basse temperature et en champ fort, a une situation 'pratiquement sans bande interdite' pres de T{sub CNS} en champ nul. Ceci fournit une preuve de la non divergence de la longueur de coherence a T{sub CNS}. Les techniques experimentales (et en particulier la preparation et la mesure de jonctions tunnel) sont decrites en detail dans une annexe. On envisage des applications pratiques possibles. (auteur)

  16. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Science.gov (United States)

    Pillet, Flavien; Passot, Fanny Marie; Pasta, Franck; Anton Leberre, Véronique; Bouet, Jean-Yves

    2017-01-01

    Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  17. La pelade par plaques

    Science.gov (United States)

    Spano, Frank; Donovan, Jeff C.

    2015-01-01

    Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre l’épidémiologie, la pathogenèse, l’histologie et l’approche clinique au diagnostic de la pelade par plaques. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant la pathogenèse, le diagnostic et le pronostic de la pelade par plaques. Message principal La pelade par plaques est une forme de perte pileuse auto-immune dont la prévalence durant une vie est d’environ 2 %. Des antécédents personnels ou familiaux de troubles auto-immuns concomitants, comme le vitiligo ou une maladie de la thyroïde, peuvent être observés dans un petit sous-groupe de patients. Le diagnostic peut souvent être posé de manière clinique en se fondant sur la perte de cheveux non cicatricielle et circulaire caractéristique, accompagnée de cheveux en « point d’exclamation » en périphérie chez ceux dont le problème en est aux premiers stades. Le diagnostic des cas plus complexes ou des présentations inhabituelles peut être facilité par une biopsie et un examen histologique. Le pronostic varie largement et de mauvais résultats sont associés à une apparition à un âge précoce, une perte importante, la variante ophiasis, des changements aux ongles, des antécédents familiaux ou des troubles auto-immuns concomitants. Conclusion La pelade par plaques est une forme auto-immune de perte de cheveux périodiquement observée en soins primaires. Les médecins de famille sont bien placés pour identifier la pelade par plaques, déterminer la gravité de la maladie et poser le diagnostic différentiel approprié. De plus, ils sont en mesure de renseigner leurs patients à propos de l’évolution clinique de la maladie ainsi que du pronostic général selon le sous-type de patients.

  18. Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

    Science.gov (United States)

    Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

    2009-09-01

    To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.

  19. Kerr effect in the isotropic phase of a side-chain polymeric liquid crystal

    Science.gov (United States)

    Reys, V.; Dormoy, Y.; Collin, D.; Keller, P.; Martinoty, P.

    1992-02-01

    The birefringence induced by a pulsed electrical field was used to study the pretransitional effects associated with the isotropic phase of a side-chain polysiloxane. The results obtained show that these effects are characterised by a conventional value of the static exponent and an abnormal value of the dynamic exponent, which shows that the dynamic theory of low molecular weight liquid crystals does not apply. The results also reveal competition between the dipolar moments induced by the electrical field and the permanent moments of the mesogenic molecules. La biréfringence induite par un champ électrique impulsionnel a été utilisée pour étudier les effets prétransitionnels associés à la phase isotrope d'un polysiloxane à chaînes latérales. Les résultats obtenus montrent que ces effets sont caractérisés par une valeur classique de l'exposant statique et une valeur anormale de l'exposant dynamique. Ce dernier résultat montre que la théorie dynamique des cristaux liquides de bas poids moléculaire n'est pas applicable au cas présent. Les expériences mettent également en évidence une compétition entre les moments dipolaires induits par le champ électrique et les moments permanents des molécules mésogènes.

  20. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly......, hence identifying the N terminus of ParB as a requirement for ParB-mediated centromere pairing. These observations suggest that centromere pairing is an important intermediate step in plasmid partitioning mediated by the common type I loci....

  1. CM5, a Pre-Swarm Comprehensive Geomagnetic Field Model Derived from Over 12 Yr of CHAMP, Orsted, SAC-C and Observatory Data

    Science.gov (United States)

    Sabaka, Terence J.; Olsen, Nils; Tyler, Robert H.; Kuvshinov, Alexey

    2014-01-01

    A comprehensive magnetic field model named CM5 has been derived from CHAMP, Ørsted and SAC-C satellite and observatory hourly-means data from 2000 August to 2013 January using the Swarm Level-2 Comprehensive Inversion (CI) algorithm. Swarm is a recently launched constellation of three satellites to map the Earth's magnetic field. The CI technique includes several interesting features such as the bias mitigation scheme known as Selective Infinite Variance Weighting (SIVW), a new treatment for attitude error in satellite vector measurements, and the inclusion of 3-D conductivity for ionospheric induction. SIVW has allowed for a much improved lithospheric field recovery over CM4 by exploiting CHAMP along-track difference data yielding resolution levels up to spherical harmonic degree 107, and has allowed for the successful extraction of the oceanic M2 tidal magnetic field from quiet, nightside data. The 3-D induction now captures anomalous Solar-quiet features in coastal observatory daily records. CM5 provides a satisfactory, continuous description of the major magnetic fields in the near-Earth region over this time span, and its lithospheric, ionospheric and oceanic M2 tidal constituents may be used as validation tools for future Swarm Level-2 products coming from the CI algorithm and other dedicated product algorithms.

  2. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  3. CFD analysis of PAR performance as function of inlet design

    International Nuclear Information System (INIS)

    Park, Kweonha; Khor, Chong Lee

    2016-01-01

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  4. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  5. Contribution to the analysis of light elements using x fluorescence excited by radio-elements; Contribution a l'analyse des elements legers par fluorescence x excitee au moyen de radioelements

    Energy Technology Data Exchange (ETDEWEB)

    Robert, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    In order to study the possibilities of using radioactive sources for the X-fluorescence analysis of light elements, the principle is given, after a brief description of X-fluorescence, of the excitation of this phenomenon by X, {beta} and {alpha} emission from radio-elements. The operation and use of the proportional gas counter for X-ray detection is described. A device has been studied for analysing the elements of the 2. and 3. periods of the Mendeleev table. It makes it possible to excite the fluorescence with a radioactive source emitting X-rays or a particles; the X-ray fluorescence penetrates into a window-less proportional counter, this being made possible by the use of an auxiliary electric field in the neighbourhood of the sample. The gas detection pressure leading to the maximum detection yield is given. The spectra are given for the K{sub {alpha}} lines of 3. period elements excited by {sup 55}Fe, {sup 3}H/Zr and {sup 210}Po sources; for the 2. period the K{sub {alpha}} spectra of carbon and of fluorine excited by the {alpha} particles of {sup 210}Po. (author) [French] Afin d'etudier les possibilites d'emploi de sources radioactives a l'analyse par fluorescence X des elements legers, on presente apres rappel de notions generales sur la fluorescence X, le principe de l'excitation de ce phenomene par emission X, {beta}, {alpha} de radioelements. Le fonctionnement et l'utilisation du compteur proportionnel a gaz a la detection du rayonnement X est developpe. Un dispositif permettant l'analyse des elements des 2eme et 3eme periodes de la classification de Mendeleev est etudie. Il permet l'excitation de la fluorescence par source radioactive emettrice de rayons X ou de particules {alpha}; le rayonnement X de fluorescence penetre dans un compteur proportionnel depourvu de fenetre, ceci est rendu possible en creant un champ electrique auxiliaire au voisinage de l'echantillon. On definit une pression du gaz de detection

  6. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  7. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  8. Process intensification in artificial gravity

    OpenAIRE

    Munteanu, Mugurel-Catalin

    2008-01-01

    L'amélioration des propriétés hydrodynamiques des réacteurs chimiques est toujours un grand défi pour les ingénieurs en génie des procèdes. La réalisation d'expériences sur des réacteurs chimiques situés dans un champ magnétique inhomogène peut donner des informations importantes concernant les mécanismes des réactions chimiques ou les propriétés hydrodynamiques du système. Un champ magnétique inhomogène sera généré par un aimant solénoïdal à supraconductivité NbTi et appliqué à un réacteur c...

  9. HIV in (and out of) the clinic: Biomedicine, traditional medicine and ...

    African Journals Online (AJOL)

    ... de la Clinique biome´dicale (et autres pratiques 'alternatives' de gue´rison) comme etant comprises en tant que champs ide´ologiques et experts en contestation. Le but de cet article est de renforcer notre connaissance de la relation entre la gue´rison traditionnelle et la gue´rison par la foi en rapport avec la biome´dicine ...

  10. De la forêt aux champs en Côte d'Ivoire | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    3 févr. 2011 ... Une étude de 1996, dirigée par Pascal Houénou de l'Université de Abobo ... Le danger, comme l'ont constaté les chercheurs, c'est que les .... des inondations provoquées par les crues de l'Indus en 2010 sur le Pakistan.

  11. Champs et discours d’un genre

    Directory of Open Access Journals (Sweden)

    Jan Blanc

    2006-09-01

    Full Text Available Cet article se propose d’élaborer – et de tenter, au moins partiellement, de résoudre – une question à laquelle je me suis souvent confronté, dans mes recherches consacrées aux traités de peinture néerlandais du xviie siècle, et qui est longtemps restée pour moi une véritable énigme : pourquoi l’Introduction à la haute école de l’art de peinture (Inleyding tot de hooge schoole der schilderkonst, écrite par le peintre et théoricien Samuel Van Hoogstraten et publiée en 1678, a fait l’objet d’u...

  12. Concerning the dynamic instability of actin homolog ParM

    International Nuclear Information System (INIS)

    Popp, David; Yamamoto, Akihiro; Iwasa, Mitsusada; Narita, Akihiro; Maeda, Kayo; Maeda, Yuichiro

    2007-01-01

    Using in vitro TIRF- and electron-microscopy, we reinvestigated the dynamics of native ParM, a prokaryotic DNA segregation protein and actin homolog. In contrast to a previous study, which used a cysteine ParM mutant, we find that the polymerization process of wild type ATP-ParM filaments consists of a polymerization phase and a subsequent steady state phase, which is dynamically unstable, like that of microtubules. We find that the apparent bidirectional polymerization of ParM, is not due to the intrinsic nature of this filament, but results from ParM forming randomly oriented bundles in the presence of crowding agents. Our results imply, that in the bacterium, ParM filaments spontaneously form bipolar bundles. Due to their intrinsic dynamic instability, ParM bundles can efficiently 'search' the cytoplasmic lumen for DNA, bind it equally well at the bipolar ends and segregate it approximately symmetrically, by the insertion of ParM subunits at either end

  13. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...

  14. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  15. Contribution to the microwave characterisation of superconductive materials by means of sapphire resonators; Contribution a la caracterisation hyperfrequence de materiaux supraconducteurs par des resonateurs-saphirs

    Energy Technology Data Exchange (ETDEWEB)

    Hanus, Xavier

    1993-12-06

    The objective of this research thesis is to find a compact resonant structure which would allow the residual surface impedance of superconductive samples to be simply, quickly and economically characterised. The author first explains why he decided to use a sapphire single-crystal as inner dielectric, given some performance reached by resonant structures equipped with such inner dielectrics, and given constraints adopted from the start. He explains the origin of microwave losses which appear in this type of resonant structure, i.e. respectively the surface impedance as far as metallic losses are concerned, and the sapphire dielectric loss angle for as far as dielectric losses are concerned. The experimental installation and the principle of microwave measurements are described. The performance of different possible solutions of resonant structures from starting criteria is presented. The solution of the cavity-sapphire with a TE{sub 011} resonant mode is derived [French] Le but de cette etude est de trouver une structure resonnante compacte permettant de caracteriser simplement, rapidement et economiquement l'impedance de surface residuelle d'echantillons supraconducteurs. Les contraintes de mise en oeuvre et les performances atteintes par des resonateurs avec saphirs synthetiques justifient le choix d'un tel dielectrique a faible angle de perte. L'evaluation des performances experimentales appuyee par des modelesanalytiques permet de rejeter differentes solutions. Ainsi les resonateurs fermes avec saphirs minces sont rejetes en raison des mauvais contacts metalliques. Les resonateurs ouverts avec saphirs minces et epais sont egalement rejetes, meme pour les modes de resonance en principe confines, en raison des pertes par rayonnement. La seule solution est donc d'utiliser une cavite-saphir TE{sub 011} qui offre une configuration de champs naturellement confines. Des mesures sur une premiere cavite en niobium massif ont permis de selectionner un saphir obtenu par

  16. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  17. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  18. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...

  19. Levitation of water and organic substances in high static magnetic fields

    Science.gov (United States)

    Beaugnon, E.; Tournier, R.

    1991-08-01

    The levitation of various diamagnetic liquid and solid substances such as water, ethanol, acetone, bismuth, antimony, graphite, wood and plastic has been achieved at room temperature in a strong inhomogeneous static magnetic field. These experiments were performed in the hybrid magnet at the Service National des Champs Intenses (CNRS, Grenoble). These findings show that high field superconducting magnets could be used to provide a contactless, low gravity environment for the elaboration of a wide range of materials. En utilisant les forts champs magnétiques produits par la bobine hybride du Service National des Champs Intenses (CNRS, Grenoble), nous avons obtenu àtempérature ambiante la lévitation de substances diamagnétiques solides ou liquides telles que l'eau, l'alcool, l'acétone, le bismuth, l'antimoine, le graphite, le bois et le plastique. Ces résultats montrent que les bobines supraconductrices peuvent être utilisées pour l'élaboration de nombreux matériaux en gravité réduite, sans contact avec un contenant.

  20. Bibenligne

    Directory of Open Access Journals (Sweden)

    Véronique Ginouvès

    2012-07-01

    Full Text Available La rubrique Bibenligne propose une sélection de sites web qui concerne le champ couvert par la remmm et présente un intérêt scientifique ou documentaire. Cette rubrique est alimentée par les concepteurs et rédacteurs du site Bibenligne, sélection raisonnée de catalogues de bibliothèques et de centres documentaires en sciences humaines et sociales. http://www.bibenligne.org Avalon project - Documents in Law, History and Diplomacy http://www.bibenligne.org/index5662.html Le projet « Avalon » ...

  1. Mizrahi Jean-David, Genèse de l’État mandataire. Service des renseignements et bandes armées en Syrie et au Liban dans les années 1920, Paris, Publications de la Sorbonne, 2003, 462 p. , 12 cartes, 15 tableaux et 11 photographies.

    Directory of Open Access Journals (Sweden)

    Nadine Méouchy

    2004-12-01

    Full Text Available C’est un ouvrage important à plus d’un titre que nous livre ici Jean-David Mizrahi dont le travail minutieux enrichit notre savoir sur la période mandataire aux plans documentaire, historique et méthodologique. En premier lieu, ce travail témoigne du chemin parcouru depuis bientôt vingt ans par l’historiographie française sur le Mandat français en Syrie et au Liban, dont on sait qu’elle fut longtemps indigente dans un champ dominé par nos collègues anglo-saxons. Le précieux apport documentai...

  2. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  3. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease a...

  4. Substorm-related thermospheric density and wind disturbances derived from CHAMP observations

    Directory of Open Access Journals (Sweden)

    P. Ritter

    2010-06-01

    Full Text Available The input of energy and momentum from the magnetosphere is most efficiently coupled into the high latitude ionosphere-thermosphere. The phenomenon we are focusing on here is the magnetospheric substorm. This paper presents substorm related observations of the thermosphere derived from the CHAMP satellite. With its sensitive accelerometer the satellite can measure the air density and zonal winds. Based on a large number of substorm events the average high and low latitude thermospheric response to substorm onsets was deduced. During magnetic substorms the thermospheric density is enhanced first at high latitudes. Then the disturbance travels at an average speed of 650 m/s to lower latitudes, and 3–4 h later the bulge reaches the equator on the night side. Under the influence of the Coriolis force the travelling atmospheric disturbance (TAD is deflected westward. In accordance with present-day atmospheric models the disturbance zonal wind velocities during substorms are close to zero near the equator before midnight and attain moderate westward velocities after midnight. In general, the wind system is only weakly perturbed (Δvy<20 m/s by substorms.

  5. Comprehensive study of ULF upstream waves observed in the topside ionosphere by CHAMP and on the ground

    Directory of Open Access Journals (Sweden)

    B. Heilig

    2007-03-01

    Full Text Available Based on magnetic field measurements from the satellite CHAMP, a detailed picture could be obtained of the upstream wave (UW distribution in the topside ionosphere. The low, near-polar orbit of CHAMP, covering all local times, allows the global distribution of this type of pulsation to be revealed. The observations from space are compared to recordings of the ground-based MM100 meridional array covering the latitude range 66° to 42° in magnetic coordinates. UWs show up very clearly in the compressional component of the satellite magnetic field data, whereas on the ground, their signature is found in the H component, but it is mixed with oscillations from field line resonant pulsations. Here we first introduce a procedure for an automated detection of UW signatures, both in ground and space data. Then a statistical analysis is presented of UW pulsations recorded during a 132-day period, centred on the autumn 2001 equinox. Observations in the top-side ionosphere reveal a clear latitudinal distribution of the amplitudes. Largest signals are observed at the equator. Minima show up at about 40° latitude. The coherence between ground and satellite wave signatures is high over wide latitude and longitude ranges. We make suggestions about the entry mechanism of UWs from the foreshock region into the magnetosphere. The clear UW signature in satellite recordings between −60° and 60° latitude allows for detailed investigations of the dependence on solar wind conditions. We test the control of solar wind speed, interplanetary magnetic field strength and cone angle on UWs. For the first time, it is possible to derive details of the Doppler-shift effect by modifying the UW frequency from direct observations. The results reconcile foreshock wave generation predictions with near-Earth observations.

  6. CHAMP: Cognitive behaviour therapy for health anxiety in medical patients, a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Murphy David

    2011-06-01

    Full Text Available Abstract Background Abnormal health anxiety, also called hypochondriasis, has been successfully treated by cognitive behaviour therapy (CBT in patients recruited from primary care, but only one pilot trial has been carried out among those attending secondary medical clinics where health anxiety is likely to be more common and have a greater impact on services. The CHAMP study extends this work to examine both the clinical and cost effectiveness of CBT in this population. Method/Design The study is a randomized controlled trial with two parallel arms and equal randomization of 466 eligible patients (assuming a 20% drop-out to an active treatment group of 5-10 sessions of cognitive behaviour therapy and to a control group. The aim at baseline, after completion of all assessments but before randomization, was to give a standard simple explanation of the nature of health anxiety for all participants. Subsequently the control group was to receive whatever care might usually be available in the clinics, which is normally a combination of clinical assessment, appropriate tests and reassurance. Those allocated to the active treatment group were planned to receive between 5 and 10 sessions of an adapted form of cognitive behaviour therapy based on the Salkovskis/Warwick model, in which a set of treatment strategies are chosen aimed at helping patients understand the factors that drive and maintain health anxiety. The therapy was planned to be given by graduate research workers, nurses or other health professionals trained for this intervention whom would also have their competence assessed independently during the course of treatment. The primary outcome is reduction in health anxiety symptoms after one year and the main secondary outcome is the cost of care after two years. Discussion This represents the first trial of adapted cognitive behaviour therapy in health anxiety that is large enough to test not only the clinical benefits of treatment but also

  7. Contrôle des circuits auxiliaires des P.F.W. (arret machine 2004/2006)

    CERN Document Server

    Ottaviani, J

    2005-01-01

    Les PFW sont des nappes polaires installées sur les pôles des aimants du PS. Elles sont au nombre de 4 par unité d’aimant et constituées d’un circuit principal (dans lequel circule le courant désiré selon le cycle magnétique utilisé) et de circuits auxiliaires. Les circuits auxiliaires sont des enroulements de correction (boucles de tour et “pick-up” brasés sur les enroulements principaux). Pendant la variation du champ magnétique de l’aimant PS, on utilise des tensions induites dans ces circuits auxiliaires pour corriger les erreurs de champ dues aux pertes par courants de Foucault dans la chambre à vide. Chaque année, pendant l’arrêt machine, on vérifie si les caractéristiques des circuits auxiliaires correspondent aux normes (mesures des résistances des boucles de tours, résistances entre “pick-up” et isolation des circuits) afin de faire un suivi. Les 404 PFW sont ainsi vérifiées. Dans cette note, on ne relèvera que les PFW ayant des défauts (valeurs hors tolérances, ...

  8. Contrôle des Circuits Auxiliaires des P.F.W. (arrêt machine 2003/2004)

    CERN Document Server

    Ottaviani, J

    2004-01-01

    Les PFW sont des nappes polaires installées sur les pôles des aimants du PS. Elles sont au nombre de 4 par unité d'aimant et constituées d'un circuit principal (dans lequel circule le courant désiré selon le cycle magnétique utilisé) et des circuits auxiliaires. Les circuits auxiliaires sont des enroulements de correction (boucles de tour et "pick-up" brasés sur les enroulements principaux). Pendant la variation du champ magnétique del'aimant PS, on utilise des tensions induites dans ces circuits auxiliaires pour corriger les erreurs de champ dues aux pertes par courants de Foucault dans la chambre à vide. Chaque année, pendant l'arrêt machine, on vérifie si les caractéristiques des circuits auxiliaires correspondent aux normes (mesures de résistances des boucles de tours, résistances entre "pick-up" et isolation des circuits) afin de faire un suivi. Les 404 PFW sont ainsi vérifiées. Dans cette note, on ne relèvera que les PFW ayant des défauts (valeurs hors tolérances, boucles ouvertes ...

  9. Study of superconductors of the second type in the lead-thallium system; Etude des supraconducteurs de la deuxieme espece du systeme plomb-thallium

    Energy Technology Data Exchange (ETDEWEB)

    Bon Mardion, G [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-07-01

    The author has shown by magnetization measurements on lead-thallium alloys having from 5 to 70 atom per cent of thallium, that superconductors of the second type definitively exist. The results obtained, in particular on the upper critical field H{sub C2} are in good agreement with the models of Ginzburg, Landau, Abrikosov, Gorkov and Goodman. Finally resistivity measurements have confirmed the occurrence of a fourth upper critical field, the existence of which has been theoretically predicted by St James and de Gennes. (author) [French] L'auteur par des mesures d'aimantation sur les alliages plomb-thallium, de composition variant de 5 pour cent a 70 pour cent At. de thallium, a montre qu'il fallait admettre definitivement l'existence des supraconducteurs de la deuxieme espece. Les resultats obtenus, en particulier sur le champ critique superieur H{sub c2} sont en bon accord avec les modeles de Ginzburg, Landau, Abrikosov, Gorkov et Goodman. Enfin des mesures de resistivite ont confirme l'existence d'un quatrieme champ critique superieur H{sub c3}, existence prevue theoriquement par St James et de Gennes. (auteur)

  10. Nuclear magnetic resonance at 310 MHz in a superconducting solenoid; Resonance magnetique nucleaire a 310 MHz dans un solenoide supra-conducteur

    Energy Technology Data Exchange (ETDEWEB)

    Dunand, J.J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1970-07-01

    The realisation of an NMR spectrometer with a superconducting magnet is presented in the first section. The methods to attain the best possible homogeneity of the magnetic field and to minimize the error in the spectrometer are described. The second section is devoted to the study of elastomers and nitr-oxides free radicals. A shift of the transition temperature with the magnetic field appears for the elastomers. The increasing paramagnetic shift has allowed a complete study by NMR of piperidinic and pyrrolidinic nitroxide free radicals. (author) [French] Dans la premiere partie est exposee la realisation d'un spectrometre de RMN utilisant un solenoide supraconducteur. Des solutions sont donnees pour obtenir la meilleure homogeneite possible du champ magnetique et pour minimiser les sources d'erreur apportees par le spectrometre. La deuxieme partie est consacree a l'etude d'elastomeres et de radicaux libres nitroxydes. Une variation de la temperature de transition avec le champ magnetique est mise en evidence pour les elastomeres. L'accroissement du deplacement paramagnetique a permis une etude complete par RMN des radicaux libres nitroxydes piperidiniques et pyrrolidiniques. (auteur)

  11. Optimization on Extraction Engineering of the Anti - inflammatory Bioactive Materials from Ainsliaea Fragrans Champ

    Directory of Open Access Journals (Sweden)

    Yang Jie

    2016-01-01

    Full Text Available Ainsliaea fragrans Champ.(A.fragrans is a traditional Chinese herbal, phenolic compounds was the major anti - inflammatory bioactive constituents. To improve the bioavailability and enhanced the curative effect of A.fragrans, the anti - inflammatory effect of phenolic acids and the “non-active” group of control vectors constitute a new biomedical material, which is of great significance to the treatment of diseases inflammation. Hence, in this thesis, regarding the total phenolic acid transfer rate as the indicator, L9(34 orthogonal design was used to optimize the extraction process of total Phenolic acid from A.fragrans by reflux extraction method on solvent dosage, extraction times and extraction time.The optimal extraction technology was as follows: 15 times of water volume, reflux extraction 3 times, extraction time 60 min. The result of pharmacological activity indicated anti-inflammatory effect: 95% ethanol extraction > water extraction > 30% ethanol extraction > 60% ethanol extraction.

  12. Motion of Plasmoid in a Curvilinear Magnetic Field; Mouvement d'un Plasmoide dans un Champ Magnetique Curviligne; Dvizhenie plazmennogo sgustka v krivolinejnom magnitnom pole; Movimiento de un Plasmoide en un Campo Magnetico Curvilineo

    Energy Technology Data Exchange (ETDEWEB)

    Vojcenja, V. S.; Gorbanjuk, A. G.; Onishhenko, I. N.; Safronov, B. G.; Hizhnjak, N. A.; Shkoda, V. V. [Fiziko-Tehnicheskij Institut, AN USSR, Khar' kov, USSR (Ukraine)

    1966-04-15

    'empechent pas la derive des ions lourds vers; les parois de la chambre. Meme dans les plasmas denses ou 4{pi}n{sub 0}Mc{sup 2}/H{sup 2}{sub 0} >> 1, la derive des ions lourds est soumise aux memes lois que dans l'approximation a une seule particule. Une analyse plus precise de la structure des champs montre qu'en plus du champ de polarisation perpendiculaire au plan du tore, il existe un champ electrique radial dirige vers la paroi interne de la chambre torique. La grandeur du champ de polarisation est determinee essentiellement par des 'courants de raccourcissement ' et, par consequent, la mesure des champs de polarisation confirme indirectement l'hypothese de l'existence de ces champs. Des experiences anterieures oni montre que l'ordre de grandeur des champs de polarisation mesures est en bon accord avec celui des valeurs prevues. Dans le present memoire les auteurs etudient les resultats de la recherche experimentale sur le passage et la decontamination de plasmoiedes rapides a densite elevee (n{sub 0} > 10{sup 13} cm{sup -3}, 4{pi}n{sub 0}Mc{sup 2}/H{sup 2}{sub 0} Asymptotically-Equal-To 5 x 10{sup 3} >> 1). Pour obtenir les plasmoiedes, les auteurs ont utilise une source coaxiale avec admission de gaz puise (1 cm3 d'hydrogene a la pression atmospherique). La batterie source, d'une capacite de 17 {mu}F, etait chargee a 18 kV. Apres le passage a travers la section rectiligne du champ magnetique (L = 150 cm) le plasma est entre dans le champ magnetique torique (rayon de courbure, 75 cm, angle de deflection, environ 90 Degree-Sign ). L'intensite du champ magnetique puise a atteint 10 kOe et est restee pratiquement inchangee pendant le passage du plasma (T = 10 ms). Pour l'utilisation des plasmoiedes on a eu recours a un spectrographe de masse de Thompson, a un analyseur de masse de transit, a des sondes electriques et de haute frequence, a des calorimetres et a un plasmoscope. A l'entree dans le solenoiede torique la vitesse des fronts de plasma de densite n{sub 1} Tilde

  13. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  14. Schéma directeur des Systèmes d'information 2012-2016

    OpenAIRE

    Institut National de Recherche Agronomique UAR 0776 Administration du siège

    2012-01-01

    Le schéma directeur des systèmes d’information de l’inra est le premier Schéma directeur dont l’institut se dote dans le champ des systèmes D’information. Il couvre la période 2012‐2016 du contrat d’objectifs Et s’inscrit dans les perspectives scientifiques dressées par le document D’orientation 2010‐2020

  15. REACTION OF LOCAL ACCESSIONS OF CASSAVA TO DISEASES ...

    African Journals Online (AJOL)

    ACSS

    2015-02-19

    Feb 19, 2015 ... En utilisant la technique d'hybridation de l'ADN et l'essai d'immuno-absorption enzymatique (ELISA), un nombre important de ces accessions ont été vus capable de résister au virus de la mosaïque du manioc. La pourriture des racines causées par les polypores a été observée dans quelques champs des ...

  16. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  17. Réduction du nombre de puits par l'utilisation de forages horizontaux Reducing the Number of Wells by Using Horizontal Drilling

    Directory of Open Access Journals (Sweden)

    Giger F.

    2006-11-01

    Full Text Available L'un des intérêts du forage horizontal est le gain de productivité sur chaque puits. L'objet de cet article est de proposer des éléments d'analyse, comme la productivité surfacique, destinés à aider l'instance responsable du développement d'un champ confrontée au choix économique entre un schéma classique par puits verticaux et un autre schéma intégrant des puits d'un autre type, et notamment des drains horizontaux. Des méthodes de résolution approchées d'emploi simple sont proposées pour évaluer le nombre de puits verticaux que peut remplacer un drain ho-rizontal. One of the advantages of horizontal drilling is the increase in productivity of each well. The aim of this article is to propose bases for making an analysis, such as areal productivity, so as to help the decision-maker responsible for the development of a field when confronted with an economic choice between a conventional system using vertical wells and an alternative system including other types of wells, and in particular horizontal wells. Simple and approximate solutions are proposed for evaluating the number of vertical wells that can be replaced by a horizontal wells.

  18. Etudes optiques de nouveaux materiaux laser: Des orthosilicates dopes a l'ytterbium: Le yttrium (lutetium,scandium) pentoxide de silicium

    Science.gov (United States)

    Denoyer, Aurelie

    La decouverte et l'elaboration de nouveaux materiaux laser solides suscitent beaucoup d'interet parmi la communaute scientifique. En particulier les lasers dans la gamme de frequence du micron debouchent sur beaucoup d'applications, en telecommunication, en medecine, dans le domaine militaire, pour la, decoupe des metaux (lasers de puissance), en optique non lineaire (doublage de frequence, bistabilite optique). Le plus couramment utilise actuellement est le Nd:YAG dans cette famille de laser, mais des remplacants plus performants sont toujours recherches. Les lasers a base d'Yb3+ possedent beaucoup d'avantages compares aux lasers Nd3+ du fait de leur structure electronique simple et de leur deterioration moins rapide. Parmi les matrices cristallines pouvant accueillir l'ytterbium, les orthosilicates Yb:Y 2SiO5, Yb:Lu2SiO5 et Yb:Sc2SiO 5 se positionnent tres bien, du fait de leur bonne conductivite thermique et du fort eclatement de leur champ cristallin necessaire a l'elaboration de lasers quasi-3 niveaux. De plus l'etude fine et systematique des proprietes microscopiques de nouveaux materiaux s'avere toujours tres interessante du point de vue de la recherche fondamentale, c'est ainsi que de nouveaux modeles sont concus (par exemple pour le champ cristallin) ou que de nouvelles proprietes inhabituelles sont decouvertes, menant a de nouvelles applications. Ainsi d'autres materiaux dopes a l'ytterbium sont connus pour leurs proprietes de couplage electron-phonon, de couplage magnetique, d'emission cooperative ou encore de bistabilite optique, mais ces proprietes n'ont encore jamais ete mises en evidence dans Yb:Y 2SiO5, Yb:Lu2SiO5 et Yb:Sc2SiO 5. Ainsi, cette these a pour but l'etude des proprietes optiques et des interactions microscopiques dans Yb:Y2SiO 5, Yb:Lu2SiO5 et Yb:Sc2SiO5. Nous utilisons principalement les techniques d'absorption IR et de spectroscopie Raman pour determiner les excitations du champ cristallin et les modes de vibration dans le materiau

  19. Serum suPAR in patients with FSGS: trash or treasure?

    Science.gov (United States)

    Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

    2013-07-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

  20. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  1. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  2. Efficacité du renforcement des poutres en béton armé par des matériaux composites Efficiency of strengthening concrete beams using FRP

    Directory of Open Access Journals (Sweden)

    Chemrouk M

    2012-09-01

    Full Text Available Pour réduire le coût et assurer un comportement relativement plus ductile pour des éléments en béton armés renforcés, l’addition des fibres de verre pourrait être considérée comme solution de rechange, puisqu’elles sont relativement plus déformables et meilleur marché que la fibre de carbone. Dans ce sens, le travail actuel vise à évaluer l’efficacité du renfort externe sur les poutres renforcées par le tissu de FRP (verre-carbone. Un total de sept poutres en béton armé a été renforcé en flexion et en cisaillement, et testé sous un chargement quatre points cyclique statique. Les champs des contraintes et de déformation ont été contrôlés par un système de caméra numérique “Gom-Aramis”. Les résultats ont été analysés en termes de résistance, rigidité, ductilité et mode de rupture. To reduce the cost and to ensure a behavior relatively more ductile for concrete strengthening elements, the addition of glass fibers could be regarded as solution of replacement, since they are relatively more deformable and cheaper than carbon fiber. In this sense, current work aims at evaluating the effectiveness of the external reinforcement on the beams strengthened by fabric of FRP (glass – carbon. Seven concrete beams reinforced were strengthening in bending and shearing, and were testing under four point cyclic static. The fields of the stresses and deformation were controlled by a numerical system of camera “Gom-Aramis”. The results were analyzing in term of resistance, rigidity, ductility and mode of failure

  3. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  4. Développer des compétences interactionnelles en collaborant à distance

    Directory of Open Access Journals (Sweden)

    Charlotte Dejean-Thircuir

    2010-01-01

    Full Text Available Cet article vise à montrer de quelles façons des étudiants d’un Master2 professionnel de didactique des langues engagés dans la réalisation d’une tâche collaborative à distance sont amenés à mettre en œuvre et à développer des compétences interactionnelles et des compétences instrumentales en construisant des schèmes d’utilisation de l’outil de communication qu’est le chat, dans ce contexte particulier. Cette étude s’inscrit dans le champ de la communication pédagogique médiatisée par ordinateur; l’analyse des interactions verbales entre étudiants s’appuie sur des outils issus du champ de la pragmatique linguistique interactionniste.

  5. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  6. Start of enrolment for the Champs-Fréchets crèche (EVE)

    CERN Multimedia

    HR Department

    2008-01-01

    As announced in Bulletin 43/2007, CERN signed an agreement with the commune of Meyrin on 17 October 2007 under which 20 places will be reserved for the children of CERN personnel in the Champs-Fréchets day care centre (EVE), which will open on Monday, 25 August, and CERN will contribute to the funding. This agreement allows members of the CERN personnel (employees and associates) access to the crèche, for children aged between 4 months and 4 years, irrespective of where they are living. Applications for the school year starting autumn 2008 will be accepted from Monday 17 March until Monday 30 June 2008. Members of the personnel must complete the enrolment formalities with the Meyrin infant education service themselves: Mairie de Meyrin Service de la Petite Enfance 2 rue des Boudines Case postale 367 - 1217 Meyrin 1 - Tel. + 41 (0)22 782 21 21 mailto:meyrin@meyrin.ch http://www.meyrin.ch/petiteenfance Application forms (in PDF) can be downloaded from the website of the com...

  7. « Culture populaire », « culture de masse » : une définition ou un préalable ?

    OpenAIRE

    Ory, Pascal

    2017-01-01

    Parmi les notions en usage dans le champ historien, celles de « culture populaire » et de « culture de masse » se caractérisent par une définition des plus incertaines – incertitude encore aggravée par la tendance de certains à les confondre l’une avec l’autre. Je voudrais ici restreindre cette incertitude en proposant, en effet, une telle définition. Mais comme – je l’annonce d’emblée – je rapprocherai l’une de l’autre plus que je ne les distinguerai, j’espère ne pas ajouter à la confusion… ...

  8. Abattoirs et industrialisation de la production de la viande

    Directory of Open Access Journals (Sweden)

    Anne-Elène Delavigne

    2010-03-01

    Full Text Available Une nouvelle ethnographie des abattoirsSaluons l'initiative de la collection « Natures sociales », dirigée par François Sigaut et Raphaël Larrère (édition MSH / Quae qui permet une nouvelle publication sur la thématique des abattoirs, vingt et un ans après l'ouvrage de Noélie Vialles, Le Sang et la Chair. Cet ouvrage qui a fait autorité en sciences sociales sur le sujet était d'ailleurs également publié par la Maison des Sciences de l'Homme. Depuis cette publication en 1987, le champ est tou...

  9. Innovation

    OpenAIRE

    2012-01-01

    Présenté par FutuRIS, plate-forme prospective sur la recherche, l’innovation et la société animée par l’Association Nationale de la Recherche et de la Technologie, ce volume livre un panorama du système français de recherche et d’innovation dans son environnement européen. Sont abordés dans une première partie les champs décisionnels concernés, les politiques nationales menées en matière de R&D, les relations entre enseignement supérieur et recherche et l’Espace européen de la recherche à l’h...

  10. Vers une sociologie économique des singularités littéraires

    Directory of Open Access Journals (Sweden)

    Anthony Glinoer

    2010-01-01

    Full Text Available Passé relativement inaperçu en sociologie de l’art et en sociologie de la littérature mais amplement discuté par des sociologues et des économistes, voici un livre qui pourrait grandement contribuer à un renouvellement de la pensée sociologique sur le littéraire, voire à un salutaire changement de perspective.  La sociologie de la littérature ― et tout particulièrement les travaux inspirés par la théorie du champ littéraire de Pierre Bourdieu ― s’est en effet largement consacrée à la question...

  11. Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

    Science.gov (United States)

    Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

    2018-02-14

    Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  12. Preparation of high critical temperature YBa{sub 2}Cu{sub 3}O{sub 7} superconducting coatings by thermal spray; Elaboration par projection a chaud de revetements supraconducteurs a haute temperature critique de type YBa{sub 2}Cu{sub 3}O{sub 7}

    Energy Technology Data Exchange (ETDEWEB)

    Lacombe, Jacques

    1991-09-20

    The objective of this research thesis is the elaboration of YBa{sub 2}Cu{sub 3}O{sub 7} superconducting coatings by thermal spray. These coatings must have a high adherence, a high cohesion, and the best possible electrical characteristics. The author first briefly presents physical-chemical characteristics of this ceramic, and proposes a bibliographical synthesis on thick coatings prepared by thermal spray. In the next parts, he studies and describes conditions of elaboration of poly-granular coatings of YBa{sub 2}Cu{sub 3}O{sub 7}, and their structural and electric characteristics [French] Des revetements epais de YBa{sub 2}Cu{sub 3}O{sub 7} ont ete elabores par projection a chaud sur des substrats d'acier inoxydable revetus d'une sous-couche de Ni-Cr-Al-Y. Les principales etapes du processus de fabrication sont les suivantes: - preparation de la poudre par voie humide selon un procede mis au point au C.E.R.E.M., - realisation des revetements epais par projection a chaud de cette poudre selon trois differentes techniques: projection plasma atmospherique, projection plasma sous pression reduite, projection flamme oxyacetylenique. - traitement thermique en deux etapes des revetements pour recristalliser la phase YBa{sub 2}Cu{sub 3}O{sub 7} et la reoxygener (traitement thermique dans un four sous oxygene). Les depots elabores selon cette voie sont adherents et homogenes a la fois en composition et en morphologie. La phase supraconductrice YBa{sub 2}Cu{sub 3}O{sub 7} determinee par diffraction de rayons X est bien cristallisee; elle se presente sous forme de plaquettes d'environ 10 μm de long et 1 μm d'epaisseur sans orientation preferentielle. Les revetements realises par projection plasma atmospherique presentent les meilleures caracteristiques electriques: Tc(R=0) = 90.5K; ΔTc = 1K; ρ (300 K) = 0.7 - 0.8 mΩ.cm; Jc(77 K,0 T) = 1000 A/cm{sup 2}. Les proprietes d'ecrantage magnetique ont ete comparees a celles de materiaux utilises pour le blindage magnetique

  13. Theoretical study and construction of a multichannel {beta} spectrometer with uniform magnetic field; Etude et realisation d'un spectrometre {beta} multivoies a champ magnetique uniforme

    Energy Technology Data Exchange (ETDEWEB)

    Schussler, F [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-09-01

    After a brief survey of the interest of a multichannel beta spectrometer for studying decay schemes of short lived nuclides (30 seconds minimum, the theoretically well known characteristics of uniform magnetic field analyser (image of a large source, transmission and resolution) are briefly remembered. In the second part, the apparatus built as a result of these calculations is described. This apparatus allows the determination of beta spectra by simultaneous determination of the beta spectra in coincidence with four gamma rays predetermined in the gamma spectrum of the studied nuclide. Finally, in the last part, the experimental characteristics of the spectrometer (calibration in energy and transmission) and the first measurement of beta spectra ({sup 155}Sm) and of coincidences ({sup 24}Na), are given. (author) [French] Apres avoir brievement souligne l'interet pratique que presente un spectrometre multivoies pour l'etude des schemas de desintegration des corps radioactifs de courtes periodes (30 secondes au maximum), l'auteur effectue un rappel des caracteristiques theoriques bien connues d'un analyseur magnetique a champ uniforme (image d'une source etendue) calcul de la transmission et du pouvoir de resolution. Une deuxieme partie est consacree a la description de l'appareil realise d'apres ces calculs. Cet appareil permet le releve des spectres beta par detection, simultanee de dix groupes d'electrons d'energies differentes; il permet egalement le releve simultane des spectres beta en coincidence avec quatre rayonnements gammas preselectionnes a l'avance dans le spectre gamma du corps etudie. Dans une derniere partie enfin, sont donnees les caracteristiques experimentales du spectrometre (etalonnage en energie et en transmission) ainsi que les premiers resultats des etudes de spectre beta ({sup 155}Sm) et de coincidence ({sup 24}Na). (auteur)

  14. Observation of magnetic diffusion in the Earth's outer core from Magsat, Orsted, and CHAMP data

    DEFF Research Database (Denmark)

    Chulliat, A.; Olsen, Nils

    2010-01-01

    The frozen flux assumption consists in neglecting magnetic diffusion in the core. It has been widely used to compute core flows from geomagnetic observations. Here we investigate the validity of this assumption over the time interval 1980-2005, using high-precision magnetic data from the Magsat......, Orsted, and CHAMP satellites. A detectable change of magnetic fluxes through patches delimited by curves of zero radial magnetic field at the core-mantle boundary is associated with a failure of the frozen flux assumption. For each epoch (1980 and 2005), we calculate spatially regularized models...... of the core field which we use to investigate the change of reversed magnetic flux at the core surface. The largest and most robust change of reversed flux is observed for two patches: one located under St. Helena Island (near 20 degrees S, 15 degrees E); the other, much larger, is located under the South...

  15. Le changement comme tradition dans la recherche et la formation a la recherche en biotechnologie et en peripherie Etude de cas en sciences de la sante, sciences naturelles et genie

    Science.gov (United States)

    Bourque, Claude Julie

    Le champ de la recherche scientifique et de la formation a la recherche est traverse depuis quelques dizaines d'annees par plusieurs courants et discours associes au changement, mais peu de travaux empiriques permettent de comprendre ce qui change concretement. C'est la contribution originale de cette these au champ de l'education, plus specifiquement a l'etude sociologique de l'enseignement superieur ou sont concentrees les activites liees a la triade thematique du programme doctoral dans lequel elle a ete produite : recherche, formation et pratique. L'enquete-terrain a ete realisee en 2009 et 2010 aupres de 808 repondants affilies a 60 etablissements au Quebec et a produit un vaste materiau de nature mixte (donnees quantitatives et qualitatives). Un portrait de la nebuleuse biotechnologique qui touche les secteurs des sciences de la sante, des sciences naturelles et du genie a ete realise. Ce domaine concerne des dizaines de disciplines et se revele de nature transdisciplinaire, mais les pratiques n'y sont pas davantage marquees par le changement que celles d'autres domaines connexes. Les dynamiques sociales ont fait l'objet d'analyses comparatives dans quatre contextes: le choix des programmes, des objets et des methodes, le financement, la diffusion et la planification de la carriere. Les resultats indiquent que les echanges entre les agents traditionnellement situes au coeur des activites de recherche dominent ces dynamiques dans tous les contextes etudies. L'etude des representations au fondement des pratiques a revele l'existence de trois ecoles de pensee qui coexistent dans le champ scientifique: academique, pragmatique et economiste. Ces ecoles permettent de categoriser les agents en fonction des zones de fractures qui marquent leurs oppositions tout en identifiant ce qu'ils ont en commun. Les representations et les pratiques liees a la formation temoignent d'un habitus plutot homogene, alors que les contradictions semblent plus souvent ancrees dans des

  16. Metrolab a saisi l'opportunite de l'imagerie medicale

    CERN Multimedia

    Peclet, J C

    2003-01-01

    "Le Prix Nobel de medecine a ete decerne lundi a Paul Lauterbur et Peter Mansfield, dont les recherches ont abouti au developpement de l'imagerie par resonance magnetique nucleaire (IRM).... Ces appareils ne fonctionnent correctement que si leur champ magnetique est absolument homogene. Et c'est ici qu'intervient une petite societe genevoise, Metrolab, leader mondial dans la fabrication de magnetometres RMN, qui mesurent tres exactement cette homogeneite" (1/2 page).

  17. 2087-IJBCS-Article-Fanou André

    African Journals Online (AJOL)

    admin

    cayenne lisse au champ à Loto-Dénou, Allada en conditions d'infestation naturelle et dans la serre à l'Institut. International d'Agriculture Tropicale station du Bénin où les cochenilles ont été multipliées sur les fruits de potiron pour être lâchées à raison de 20 insectes par plant avant la pulvérisation des produits. Après.

  18. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

    Directory of Open Access Journals (Sweden)

    Gamariel Rwibasira Rudinga

    2018-02-01

    Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  20. Dynamique de nanobulles et nanoplasmas generes autour de nanoparticules plasmoniques irradiees par des impulsions ultracourtes

    Science.gov (United States)

    Dagallier, Adrien

    L'emergence des lasers a impulsion ultrabreves et des nanotechnologies a revolutionne notre perception et notre maniere d'interagir avec l'infiniment petit. Les gigantesques intensites generees par ces impulsions plus courtes que les temps de relaxation ou de diffusion du milieu irradie induisent de nombreux phenomenes non-lineaires, du doublement de frequence a l'ablation, dans des volumes de dimension caracteristique de l'ordre de la longueur d'onde du laser. En biologie et en medecine, ces phenomenes sont utilises a des fins d'imagerie multiphotonique ou pour detruire des tissus vivants. L'introduction de nanoparticules plasmoniques, qui concentrent le champ electromagnetique incident dans des regions de dimensions nanometriques, jusqu'a une fraction de la longueur d'onde, amplifie les phenomenes non-lineaires tout en offrant un controle beaucoup plus precis de la deposition d'energie, ouvrant la voie a la detection de molecules individuelles en solution et a la nanochirurgie. La nanochirurgie repose principalement sur la formation d'une bulle de vapeur a proximite d'une membrane cellulaire. Cette bulle de vapeur perce la membrane de maniere irreversible,entrainant la cellule a sa mort, ou la perturbe temporairement, ce qui permet d'envisager de faire penetrer dans la cellule des medicaments ou des brins d'ADN pour de la therapie genique. C'est principalement la taille de la bulle qui va decider de l'issue de l'irradiation laser. Il est donc necessaire de controler finement les parametres du laser et la geometrie de la nanoparticule afin d'atteindre l'objectif fixe. Le moyen le plus direct a l'heure actuelle de valider un ensemble de conditions experimentales est de realiser l'experience en laboratoire,ce qui est long et couteux. Les modeles de dynamique de bulle existants ne prennent pas en compte les parametres de l'irradiation et ajustent souvent leurs conditions initiales a partir de leurs mesures experimentales, ce qui limite la portee du modele au cas pour

  1. Application de l'A.D.L, pour la mesure du champ de vitesses instationnaires de llecoulement a Ilechappement d'un moteur a combustion interne

    Science.gov (United States)

    Boutrif, M. S.; Thelliez, M.

    1993-01-01

    We present experimental results of instantaneous velocity measurement, which were obtained by application of the laser Doppler anemometry (L.D.A.) at the exhaust pipe of a reciprocating engine under real working conditions. First of all, we show that the instantaneous velocity is monodimensional along a straight exhaust pipe, and that the boundary layer develops within a 2mm thickness. We also show that the cylinder discharges in two phases : the blow down period and the final part of exhaust stroke. We also make obvious, that the flow escapes very quickly : its velocity varies between - 100m/s and 200m/s within a period shorter than 1ms ; thereby, we do record the acoustic resonance phenomenon, when the engine speed is greater than 3 000rpm. Finally, we show that in the exhaust pipe the apparent fluctuation - i.e. the cyclic dispersion and the actual turbulence - may reach 15%. Nous présentons des résultats expérimentaux du champ de vitesses instationnaires, obtenus par adaptation et application de la vélocimétrie laser interférentielle communément appelée à effet Doppler (L.D.A.), à l'échappement d'un moteur altematif à combustion inteme en fonctionnement nominal. Tout d'abord, nous montrons que dans un tube d'échappement long et droit, la vitesse instantanée est bien monodimensionnelle et que l'écoulement occupe la quasitotalité de la section droite géométrique du tube (une couche limite d'épaisseur inférieure à 2mm se développe très près de la paroi du tube). Nous pouvons également décrire la vidange du cylindre du moteur étudié en deux phases principales : bouffée d'échappement et refoulement des gaz brûlés par le piston. Nous mettons de même en évidence l'état très pulsé de l'écoulement, puisqu'en un intervalle de temps inférieur à 1ms, la vitesse de l'écoulement varie de - 100m/s à 200m/s ; nous enregistrons ainsi l'apparition du phénomène de résonance acoustique à des vitesses de rotation supérieures à 3 500

  2. Vote par sondage uniforme incorruptible

    OpenAIRE

    Blanchard , Nicolas

    2016-01-01

    International audience; Introduit en 2012 par David Chaum, le vote par sondage uniforme (random-sample voting) est un protocole de vote basé sur un choix d'une sous-population représentative , permettant de limiter les coûts tout en ayant de nombreux avantages, principalement lorsqu'il est couplé a d'autres techniques comme ThreeBallot. Nous analysons un problème de corruptibilité potentielle où les votants peuvent vendre leur vote au plus offrant et proposons une variation du protocole reméd...

  3. Nanofabrication de boites quantiques laterales pour l'optimisation de qubits de spin

    Science.gov (United States)

    Camirand Lemyre, Julien

    On présente dans ce travail un nouveau type de qubit de spin dont les performances reposent sur les propriétés d'un seul électron dans une double boîte quantique. Le fort moment dipolaire de la double boite combiné à une large variation du champ magnétique entre les deux boîtes permettrait de réaliser des opérations logiques plus rapidement que dans une seule boîte quantique. Pour maximiser les variations du champ magnétique, on utilisera un micro-aimant placé le plus près possible d'une des deux boîtes. À cette fin, une hétérostructure de GaAs/A1GaAs sur laquelle sont déposées des grilles d'aluminium a été utilisée pour former une double boite quantique latérale. L'occupation par un seul électron de la double boîte est confirmée par des mesures de transport électrique à basse température ainsi que par l'observation du blocage de spin. De plus, un procédé d'oxydation des grilles par plasma d'oxygène a été développé. Une étude des propriétés de l'oxyde formé par cette méthode montre qu'il est possible de placer un micro-aimant directement sur la surface de l'hétérostructure sans affecter l'isolation électrique entre les grilles. Cette nouvelle approche permet de produire des champs magnétiques encore plus intenses que dans les expériences antérieures, pour lesquelles le micro-aimant est placé beaucoup plus loin de la surface. L'ensemble du procédé de fabrication, de la photolithographie à l'électrolithographie, a été développé au cours de ce travail dans les salles blanches du département de génie électrique et dans les salles propres du département de physique de l'Université de Sherbrooke. Ce travail est une étape importante dans la réalisation de qubits de spin plus performants dans les boîtes quantiques latérales. Mots-clés: Information quantique, Spin, Rotations ultra-rapides, Boîtes quantiques latérales, Micro-aimants, Oxydation plasma, Nanofabrication.

  4. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  5. The role of pars flaccida in human middle ear sound transmission.

    Science.gov (United States)

    Aritomo, H; Goode, R L; Gonzalez, J

    1988-04-01

    The role of the pars flaccida in middle ear sound transmission was studied with the use of twelve otoscopically normal, fresh, human temporal bones. Peak-to-peak umbo displacement in response to a constant sound pressure level at the tympanic membrane was measured with a noncontacting video measuring system capable of repeatable measurements down to 0.2 micron. Measurements were made before and after pars flaccida modifications at 18 frequencies between 100 and 4000 Hz. Four pars flaccida modifications were studied: (1) acoustic insulation of the pars flaccida to the ear canal with a silicone rubber baffle, (2) stiffening the pars flaccida with cyanoacrylate cement, (3) decreasing the tension of the pars flaccida with a nonperforating incision, and (4) perforation of the pars flaccida. All of the modifications (except the perforation) had a minimal effect on umbo displacement; this seems to imply that the pars flaccida has a minor acoustic role in human beings.

  6. Improving Physical Fitness and Cognitive Functions in Middle School Students: Study Protocol for the Chinese Childhood Health, Activity and Motor Performance Study (Chinese CHAMPS).

    Science.gov (United States)

    Zhou, Zhixiong; Dong, Shanshan; Yin, Jun; Fu, Quan; Ren, Hong; Yin, Zenong

    2018-05-14

    Background : Sedentary lifestyles and their associated harmful consequences are public health concerns that impact more than half of the world's youth population in both developed and developing countries. Methods : The Chinese Childhood Health; Activity and Motor Performance Study (Chinese CHAMPS) was a cluster randomized controlled trial to modify school physical activity policies and the physical education (PE) curriculum; using teacher training and parent engagement to increase opportunities and support students' physical activity and healthy eating. Using a 2 × 2 factorial design, the study tested the incremental effects of increasing the amount and intensity of physical activity, alongside adding support for healthy eating, on health-related and cognitive function outcomes in Chinese middle school students. Results : The intervention was implemented by PE teachers in 12 middle schools in three Chinese cities, with a targeted enrollment of 650 students from August 2015⁻June 2016. The assessment of the outcomes involved a test battery of physical fitness and cognitive functioning at both baseline and at the end of the intervention. Process information on implementation was also collected. Discussion : The Chinese CHAMPS is a multi-level intervention that is designed to test the influences of policy and environmental modifications on the physical activity and eating behaviors of middle school students. It also addresses some key weaknesses in school-based physical activity interventions.

  7. La méthanisation agricole - Champ d'activité nouveau pour l'agriculteur

    OpenAIRE

    Claire Etrillard

    2013-01-01

    Traiter la pollution liée aux déchets et aux effluents en produisant de l'énergie renouvelable. Telle est la promesse de la méthanisation agricole actuellement promue par les pouvoirs publics. Le cadre juridique de la méthanisation à la ferme a de ce fait beaucoup évolué ces derniers temps en France. Désormais, les activités de méthanisation exercées par un exploitant agricole sont réputées agricoles, et à ce titre strictement réglementées. Quant aux produits issus de cette méthanisation, l...

  8. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    , plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  9. A crise financeira, a guerra cultural e as transformações do espaço econômico Brasileiro em 2009

    Directory of Open Access Journals (Sweden)

    Roberto Grün

    2010-01-01

    Full Text Available La crise financière qui a éclaté en 2008-2009 a déclenché ou mis à nu une série de transformations intérieures dans le monde des finances et des relations de ce monde avec l'ensemble de la société brésilienne, surtout dans les rapports entre les élites financières et le champ politique. Dans cet article, on cherche à saisir ces nouveautés et par leur biais, aider à expliquer certains points moins évidents de la notion de "champ" de la sociologie de Bourdieu, tout en approfondissant l'idée de "guerre culturelle" et en montrer la pertinence pour mieux comprendre la scène sociale brésilienne des dernières décennies

  10. PAR-1 contributes to the innate immune response during viral infection

    Science.gov (United States)

    Antoniak, Silvio; Owens, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, JoAnn; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

    2013-01-01

    Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1–/– mice expressed reduced levels of IFN-β and CXCL10 during the early phase of infection compared with Par1+/+ mice that resulted in higher viral loads and cardiac injury at day 8 after infection. Inhibition of either tissue factor or thrombin in WT mice also significantly increased CVB3 levels in the heart and cardiac injury compared with controls. BM transplantation experiments demonstrated that PAR-1 in nonhematopoietic cells protected mice from CVB3 infection. Transgenic mice overexpressing PAR-1 in cardiomyocytes had reduced CVB3-induced myocarditis. We found that cooperative signaling between PAR-1 and TLR3 in mouse cardiac fibroblasts enhanced activation of p38 and induction of IFN-β and CXCL10 expression. Par1–/– mice also had decreased CXCL10 expression and increased viral levels in the lung after influenza A infection compared with Par1+/+ mice. Our results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection. PMID:23391721

  11. Contrôle des circuits auxiliaires des P.F.W. (arret machine 2004/2006, après rénovation de 25 aimants)

    CERN Document Server

    Ottaviani, J

    2006-01-01

    Les PFW sont des nappes polaires installées sur les pôles des aimants du PS. Elles sont au nombre de 4 par unité d'aimant et constituées d'un circuit principal (dans lequel circule le courant désiré selon le cycle magnétique utilisé) et de circuits auxiliaires. Les circuits auxiliaires sont des enroulements de correction (boucles de tour et ?pick-up? brasés sur les enroulements principaux). Pendant la variation du champ magnétique de l'aimant PS, on utilise des tensions induites dans ces circuits auxiliaires pour corriger les erreurs de champ dues aux pertes par courants de Foucault dans la chambre à vide. Chaque année, pendant l'arrêt machine, on vérifie si les caractéristiques des circuits auxiliaires correspondent aux normes (mesures des résistances des boucles de tours, résistances entre ?pick-up? et isolation des circuits) afin de faire un suivi. Des mesures ont été faites au début du grand arrêt en décembre 2004 afin de définir quels aimants seraient à rénover (l'état des PFW e...

  12. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...

  13. Mesure et retroaction sur un qubit multi-niveaux en electrodynamique quantique en circuit non lineair

    Science.gov (United States)

    Boissonneault, Maxime

    L'electrodynamique quantique en circuit est une architecture prometteuse pour le calcul quantique ainsi que pour etudier l'optique quantique. Dans cette architecture, on couple un ou plusieurs qubits supraconducteurs jouant le role d'atomes a un ou plusieurs resonateurs jouant le role de cavites optiques. Dans cette these, j'etudie l'interaction entre un seul qubit supraconducteur et un seul resonateur, en permettant cependant au qubit d'avoir plus de deux niveaux et au resonateur d'avoir une non-linearite Kerr. Je m'interesse particulierement a la lecture de l'etat du qubit et a son amelioration, a la retroaction du processus de mesure sur le qubit de meme qu'a l'etude des proprietes quantiques du resonateur a l'aide du qubit. J'utilise pour ce faire un modele analytique reduit que je developpe a partir de la description complete du systeme en utilisant principalement des transfprmations unitaires et une elimination adiabatique. J'utilise aussi une librairie de calcul numerique maison permettant de simuler efficacement l'evolution du systeme complet. Je compare les predictions du modele analytique reduit et les resultats de simulations numeriques a des resultats experimentaux obtenus par l'equipe de quantronique du CEASaclay. Ces resultats sont ceux d'une spectroscopie d'un qubit supraconducteur couple a un resonateur non lineaire excite. Dans un regime de faible puissance de spectroscopie le modele reduit predit correctement la position et la largeur de la raie. La position de la raie subit les decalages de Lamb et de Stark, et sa largeur est dominee par un dephasage induit par le processus de mesure. Je montre que, pour les parametres typiques de l'electrodynamique quantique en circuit, un accord quantitatif requiert un modele en reponse non lineaire du champ intra-resonateur, tel que celui developpe. Dans un regime de forte puissance de spectroscopie, des bandes laterales apparaissent et sont causees par les fluctuations quantiques du champ electromagnetique

  14. Physical activity in childhood and the association with myopia in adolescence – The CHAMPS Eye Study

    DEFF Research Database (Denmark)

    Lundberg, Lars Kristian; Vestergaard, Anders Højslet; Jacobsen, Nina

    Purpose: Myopia is the most frequent eye disease globally and is usually caused by increasing axial growth of the eye during childhood and adolescence. Lifestyle changes such as reduced physical activity (PA) are thought to be the driving force behind the rapid increase of myopia worldwide....... The purpose of this study was to investigate the effect of PA on the development of myopia in a Danish cohort of schoolchildren. The hypothesis was that decreased PA during childhood is associated with increased axial length and myopia. Methods: A prospective study of 198 children from the CHAMPS-study DK...... cohort (Childhood Health, Activity, and Motor Performance School Study Denmark). PA was assessed with GT3X accelerometer (ActiGraph, Florida, USA) worn for 7 full consecutive days at the period August to October 2010: mean intensity was estimated as counts/min (CPM); and cut off-points for sedentary (SED...

  15. Contribution des hôpitaux de jour en psychiatrie dans le champ contemporain de la santé mentale au Québec

    Directory of Open Access Journals (Sweden)

    Marie-Laurence Poirel

    2013-10-01

    Full Text Available Actuellement au Québec, les hôpitaux de jour en psychiatrie sont des milieux de jour offrant un programme thérapeutique intensif de courte durée, principalement dans un contexte d'activités de groupe. Alors que les hôpitaux de jour sont des acteurs qui font partie intégrante du système de soins en santé mentale depuis plusieurs décennies, la question de leur rôle et de leur contribution spécifique dans le champ des approches et des pratiques de traitement et pour les personnes qu'ils rejoignent est rarement posée. Cet article s'articule autour de l'hypothèse selon laquelle les repères et les cadres actuellement dominants dans le champ de la psychiatrie et de la santé mentale permettent mal de dégager et de prendre en compte certains des paramètres dont il faut tenir compte pour parvenir à préciser et à situer le rôle et la contribution des hôpitaux de jour, dans le système de soin comme pour les personnes auxquelles ces milieux de pratique s'adressent. À partir des résultats préliminaires d'une étude exploratoire poursuivie dans quatre hôpitaux de jour où différents acteurs ont été rencontrés lors d'entrevues (personnes utilisatrices, intervenants, gestionnaires, cet article propose de dégager quelques pistes d'analyse et de réflexion.

  16. Dynamic Filament Formation by a Divergent Bacterial Actin-Like ParM Protein.

    Directory of Open Access Journals (Sweden)

    Anthony J Brzoska

    Full Text Available Actin-like proteins (Alps are a diverse family of proteins whose genes are abundant in the chromosomes and mobile genetic elements of many bacteria. The low-copy-number staphylococcal multiresistance plasmid pSK41 encodes ParM, an Alp involved in efficient plasmid partitioning. pSK41 ParM has previously been shown to form filaments in vitro that are structurally dissimilar to those formed by other bacterial Alps. The mechanistic implications of these differences are not known. In order to gain insights into the properties and behavior of the pSK41 ParM Alp in vivo, we reconstituted the parMRC system in the ectopic rod-shaped host, E. coli, which is larger and more genetically amenable than the native host, Staphylococcus aureus. Fluorescence microscopy showed a functional fusion protein, ParM-YFP, formed straight filaments in vivo when expressed in isolation. Strikingly, however, in the presence of ParR and parC, ParM-YFP adopted a dramatically different structure, instead forming axial curved filaments. Time-lapse imaging and selective photobleaching experiments revealed that, in the presence of all components of the parMRC system, ParM-YFP filaments were dynamic in nature. Finally, molecular dissection of the parMRC operon revealed that all components of the system are essential for the generation of dynamic filaments.

  17. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA......-conjugated version (NOTA-AE105) for development of the first (18)F-labeled uPAR positron-emission-tomography PET ligand using the Al(18)F radiolabeling method. In this study, the potential of (18)F-AlF-NOTA-AE105 to specifically target uPAR-positive prostate tumors was investigated....

  18. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  19. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  20. Pain, frailty and comorbidity on older men: the CHAMP study.

    Science.gov (United States)

    Blyth, Fiona M; Rochat, Stephane; Cumming, Robert G; Creasey, Helen; Handelsman, David J; Le Couteur, David G; Naganathan, Vasi; Sambrook, Philip N; Seibel, Markus J; Waite, Louise M

    2008-11-15

    Intrusive pain is likely to have a serious impact on older people with limited ability to respond to additional stressors. Frailty is conceptualised as a functional and biological pattern of decline accumulating across multiple physiological systems, resulting in a decreased capacity to respond to additional stressors. We explored the relationship between intrusive pain, frailty and comorbid burden in 1705 community-dwelling men aged 70 or more who participated in the baseline phase of the CHAMP study, a large epidemiological study of healthy ageing based in Sydney, Australia. 9.4% of men in the study were frail (according to the commonly-used Cardiovascular Health Study frailty criteria).Using a combination of self-report and clinical measures, we found an association between frailty and intrusive pain that remained after accounting for demographic characteristics, number of comorbidities, self-reported depressed mood and arthritis (adjusted odds ratio 1.7 (95% confidence interval (CI) 1.1-2.7), p=0.0149). The finding that adjusting for depressed mood, but not a history of arthritis, attenuated the relationship between frailty and intrusive pain points to a key role for central mechanisms. Additionally, men with the highest overall health burden (frail plus high comorbid burden) were most likely to report intrusive pain (adjusted odds ratio 3.0 (95% CI 1.6-5.5), p=0.0004). These findings provide support for the concept that intrusive pain is an important challenge for older men with limited capacity to respond to additional physical stressors. To our knowledge, this is the first study to explore specifically the relationship between pain and frailty.

  1. Soluble urokinase plasminogen activator receptor (suPAR) in acute care

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck

    2016-01-01

    for age, sex, Charlson score and C reactive protein. Area under the curve for receiver operating characteristics curve analysis of suPAR for 30-day mortality was 0.84 (95% CI 0.81 to 0.86). Furthermore, in the entire cohort, women had slightly higher suPAR compared with men, and suPAR was associated...

  2. Impedance de surface dans les supraconducteurs quasi-bidimensionnels

    Science.gov (United States)

    Achkir, Driss Brice

    Ce travail a caractere experimental et theorique vise l'etude de l'etat supraconducteur de trois familles de composes: les supraconducteurs conventionnels, les organiques et les cuprates YBCO. Pour ce faire, nous avons utilise une technique hyperfrequence, a savoir la mesure d'impedance de surface en fonction de la temperature et du champ magnetique. Dans les supraconducteurs conventionnels, nous avons mesure pour la premiere fois le pic de "coherence" dans la partie reelle de la conductivite. Bien que predit par la theorie BCS, ce pic n'avait pas ete clairement observe en raison de difficultes techniques liees a ce type d'experience. D'autre part, la theorie d'Eliashberg appliquee a la partie reelle de la conductivite du niobium nous a revele l'importance des mesures hyperfrequences pour mieux extraire la partie basse frequence de la densite spectrale alphasp2F(omega). Cette possibilite est attrayante puisque c'est precisement la region de frequences de alphasp2F(omega) ou les donnees d'effet tunnel sont imprecises. Les resultats obtenus sur la longueur de penetration dans les organiques et les cuprates ont permis de montrer que le gap presente des lignes de zeros au niveau de Fermi ou qu'il est, a tout le moins, fortement anisotrope. En effet, la dependance en temperature de la longueur de penetration dans les cristaux purs est lineaire a basse temperature et elle devient quadratique dans les cristaux dopes. Pour le cas des supraconducteurs organiques quasi-bidimensionnels (Et)sb2X, nous avons aussi observe un maximum sur la partie reelle de la conductivite qui n'a rien a voir avec un pic de coherence. Pour ces composes, nous avons effectue une des toutes premieres etudes des fluctuations supraconductrices en temperature et en champ magnetique. Nous montrons que la paraconductivite sigmasp' due aux fluctuations presente un comportement de type Aslamazov-Larkin de nature tridimensionnelle. Ces mesures sont appuyees par les resultats theoriques d'un modele Ginzburg

  3. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    DEFF Research Database (Denmark)

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.

    2008-01-01

    identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...... diagnostic utility. This review will focus on the mechanism of uPAR cleavage and the functional consequences, as well as the clinical applicability of cleaved uPAR forms Udgivelsesdato: 2008...

  4. Case study of inclined sporadic E layers in the Earth's ionosphere observed by CHAMP/GPS radio occultations: Coupling between the tilted plasma layers and internal waves

    Science.gov (United States)

    Gubenko, Vladimir N.; Pavelyev, A. G.; Kirillovich, I. A.; Liou, Y.-A.

    2018-04-01

    We have used the radio occultation (RO) satellite data CHAMP/GPS (Challenging Minisatellite Payload/Global Positioning System) for studying the ionosphere of the Earth. A method for deriving the parameters of ionospheric structures is based upon an analysis of the RO signal variations in the phase path and intensity. This method allows one to estimate the spatial displacement of a plasma layer with respect to the ray perigee, and to determine the layer inclination and height correction values. In this paper, we focus on the case study of inclined sporadic E (Es) layers in the high-latitude ionosphere based on available CHAMP RO data. Assuming that the internal gravity waves (IGWs) with the phase-fronts parallel to the ionization layer surfaces are responsible for the tilt angles of sporadic plasma layers, we have developed a new technique for determining the parameters of IGWs linked with the inclined Es structures. A small-scale internal wave may be modulating initially horizontal Es layer in height and causing a direction of the plasma density gradient to be rotated and aligned with that of the wave propagation vector k. The results of determination of the intrinsic wave frequency and period, vertical and horizontal wavelengths, intrinsic vertical and horizontal phase speeds, and other characteristics of IGWs under study are presented and discussed.

  5. Voies de recherche en matière de récupération assistée du pétrole par tensio-actifs Research Lines in Enhanced Oil Recovery by Surfactants

    Directory of Open Access Journals (Sweden)

    Baviere M.

    2006-11-01

    Full Text Available Quelle que soit la conjoncture économique, le procédé de récupération assistée du pétrole par injection d'agents tensio-actifs nécessite une mise en oeuvre très élaborée pour tirer le meilleur parti des produits et donc pour franchir le seuil de rentabilité. Il apparaît par ailleurs que son champ d'application doit être étendu aux conditions de réservoir couramment rencontrées, notamment les fortes salinités, par l'utilisation de structures chimiques adaptées. Pour réduire les pertes de tensio-actifs par adsorption sur la roche, et par suite, préserver l'efficacité du fluide micellaire, deux techniques sont étudiées à l'Institut Français du Pétrole. L'une d'entre elles consiste à réduire l'adsorption en augmentant le pH de la formation à l'aide d'agents alcalins. Dans l'autre méthode, les molécules adsorbées sont remises en solution par un agent désorbant ajouté à l'eau de chasse. L'extension du procédé aux gisements salés est illustrée avec une famille de tensio-actifs qui ont un comportement prometteur dans ces conditions, les sulfonates d'oléfines alpha. Il apparaît que l'efficacité interfaciale de ces produits ne doit pas être seule prise en compte, mais également la solubilité, la stabilité chimique, le comportement rhéologique et l'adsorption sur les surfaces minérales. No matter what the economic situation may be, the process of enhanced oil recovery (EOR by surfactant flooding requires very sophisticated implementation to take maximum advantage of the chemicals and hence to cross the threshold of economic feasibility. It seems, moreover, that the scope of application of this process must be enlarged to meet the reservoir conditions commonly encountered, particularly high salinity, by the use of suitable chemical structures. To reduce surfactant losses by adsorption on the rock and then to preserve the efficiency of the micellar fluid, two techniques are being investigated at the Institut

  6. A research about characteristics of longitudinal variations of ES layers irregularities based on CHAMP occultation measurements

    Science.gov (United States)

    Liao, Sunmin

    2018-04-01

    Based on the data of CHAMP occultation measurements, this paper makes a preliminary analysis of the longitudinal variations of ES irregular structure by using Fourier decomposition and reconstruction technique. It is found that the longitudinal variations of the ES irregular structure show the features of multiple wave-numbers, which is dominated by the wave number 1 to the wave number 5 components, and decrease from the amplitudes of the wave number 6 components. The features of wave number structures are very different in different DIP latitude and different seasons. The number of crests in summer and autumn is mostly 3 or 4 crest structures, while the number of crests in spring achieves 5 at DIP 15°N with small fluctuates, the crests number of winter is the least. In the multiple wave-numbers structure, the wave number 4 component shows a significant dependence on the season, mainly in the summer and autumn, particularly obvious from July to October.

  7. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  8. 2408-IJBCS-Article-Dr Amon Anoh Denis Esdras

    African Journals Online (AJOL)

    hp

    D.E. A. AMON et al. / Int. J. Biol. Chem. Sci. 9(4): 1822-1834, 2015. 1824 végétation est caractérisée par des ilots forestiers, des forêts classées et des formations anthropiques (champs, plantations). Matériel. Le matériel végétal a été composé de la flore ligneuse des agroécosystèmes et des espèces de Loranthaceae.

  9. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

    Directory of Open Access Journals (Sweden)

    Henrique FUKUSHIMA

    Full Text Available Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2 suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF of patients with moderate chronic periodontitis (MP. The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19 at baseline, and from MP patients (n = 19 and severe chronic periodontitis (SP (n = 19 patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR. PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05 PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  10. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  11. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Wanjura, D.F.; Hatfield, J.L.

    1986-01-01

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  12. Épidémiologie de l'intoxication par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Introduction: L'intoxication par envenimation est l'ensemble des manifestations locales et générales induites par la pénétration dans l'organisme d'une substance toxique produite par un animal venimeux. Le but de notre travail était d'étudier les signes cliniques des intoxications par envenimation chez les enfants de 0 à 15 ...

  13. PARs for combustible gas control in advanced light water reactors

    International Nuclear Information System (INIS)

    Hosler, J.; Sliter, G.

    1997-01-01

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  14. Brulure par Plaque de Bistouri Electrique: a Propos de Quatre Cas

    Science.gov (United States)

    Khales, A.; Achbouk, A.; Belmir, R.; Cherkab, L.; Ennouhi, M.A.; Ababou, K.; Ihrai, H.

    2010-01-01

    Summary La brûlure par plaque de bistouri électrique est un accident rare mais grave par la profondeur de la lésion et par sa localisation, surtout quand qu’elle survient dans un contexte chirurgical dont le vécu reste difficile de la part du malade et du chirurgien. Cette brûlure bien que imprévisible reste grave par la profondeur et la localisation de la brûlure et par sa survenue dans un contexte opératoire, chez des patients malades. La prise en charge de la brûlure doit se faire en milieu spécialisé. La prévention reste le seul moyen d’éviter ce type d’accident. PMID:21991216

  15. Inversion of Magnetic Measurements of the CHAMP Satellite Over the Pannonian Basin

    Science.gov (United States)

    Kis, K. I.; Taylor, P. T.; Wittmann, G.; Toronyi, B.; Puszta, S.

    2011-01-01

    The Pannonian Basin is a deep intra-continental basin that formed as part of the Alpine orogeny. In order to study the nature of the crustal basement we used the long-wavelength magnetic anomalies acquired by the CHAMP satellite. The anomalies were distributed in a spherical shell, some 107,927 data recorded between January 1 and December 31 of 2008. They covered the Pannonian Basin and its vicinity. These anomaly data were interpolated into a spherical grid of 0.5 x 0.5, at the elevation of 324 km by the Gaussian weight function. The vertical gradient of these total magnetic anomalies was also computed and mapped to the surface of a sphere at 324 km elevation. The former spherical anomaly data at 425 km altitude were downward continued to 324 km. To interpret these data at the elevation of 324 km we used an inversion method. A polygonal prism forward model was used for the inversion. The minimum problem was solved numerically by the Simplex and Simulated annealing methods; a L2 norm in the case of Gaussian distribution parameters and a L1 norm was used in the case of Laplace distribution parameters. We INTERPRET THAT the magnetic anomaly WAS produced by several sources and the effect of the sable magnetization of the exsolution of hemo-ilmenite minerals in the upper crustal metamorphic rocks.

  16. Les ouvrages pétroliers en mer Offshore Petroleum Structures

    Directory of Open Access Journals (Sweden)

    Susbielles G.

    2006-11-01

    Full Text Available Dans la conjoncture actuelle, la situation de l'offshore pétrolier semble plus prometteuse que par un passé récent car, au moins, soixante pays ont des ressources existantes ou possibles. Depuis 1975, la technique pétrolière a continué à progresser mais, surtout dans le domaine du développement des champs. Pour les plates-formes de production en acier, celles des champs de Cognac, Hondo, Ninian et Maureen se distinguent des autres, soit par leur architecture, soit par leurs dimensions. Les plates-formes en béton sont installées, pour la plupart, en mer du Nord, celle du champ de Ninian dépassant toutes les autres en dimensions. Une exception, le Brésil, avec trois plates-formes en eau peu profonde. Pour les champs marginaux, ou pour préciser les caractéristiques d'un gisement découvert, la mise en production se fait à partir de têtes de puits sous-marines, d'un manifold et de liaisons à un ouvrage flottant (plate-forme semi-submersible, tanker. Peu de modifications ont été apportées aux plates-formes semi-submersibles. Seule la plate-forme Sedco 709 est différente des autres car elle est positionnée dynamiquement. Les plus importantes opérations de levage en mer sont assurées par des grues de très forte capacité. La conception des postes de chargement reste le domaine de quelques sociétés. Quant à la pose de pipelines et de conduites, elle a évolué par l'apparition d'ouvrages tels que les barges Castoro VI de Saipem et Apache de Santa Fe et le navire Flexservice 1. Il reste aux ingénieurs à créer des systèmes de développements en mer profonde (au-delà de 500 m de profondeur d'eau. Within the present economic context, the offshore petroleum situation seems more promising than in the recent past because at least sixty countries have existing or possible resources. Since 1975 petroleum technology has continued ta advance, especially in the area of field development. For steel production platforms, the ones on

  17. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  18. suPAR

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

    2015-01-01

    Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most...... promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...

  19. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  20. Brésil : La contamination par le mercure en Amazonie | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... En tentant de déceler la source de la contamination de l'Amazone par le ... par Jean-Rémy Davy Guimaraes de l'Université fédérale de Rio de Janeiro ... ces mattes est circonscrite par la conservation et la restauration en rive.

  1. Interpretation of the Total Magnetic Field Anomalies Measured by the CHAMP Satellite Over a Part of Europe and the Pannonian Basin

    Science.gov (United States)

    Kis, K. I.; Taylor, Patrick T.; Wittmann, G.; Toronyi, B.; Puszta, S.

    2012-01-01

    In this study we interpret the magnetic anomalies at satellite altitude over a part of Europe and the Pannonian Basin. These anomalies are derived from the total magnetic measurements from the CHAMP satellite. The anomalies reduced to an elevation of 324 km. An inversion method is used to interpret the total magnetic anomalies over the Pannonian Basin. A three dimensional triangular model is used in the inversion. Two parameter distributions: Laplacian and Gaussian are investigated. The regularized inversion is numerically calculated with the Simplex and Simulated Annealing methods and the anomalous source is located in the upper crust. A probable source of the magnetization is due to the exsolution of the hematite-ilmenite minerals.

  2. Model of a plasma without collisions in a cylindrical geometry by the study of the motions of the particles (1960); Modele d'un plasma sans collisions dans une geometrie cylindrique par l'etude des mouvements de particules (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Rebut, P H [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    1960-07-01

    The Boltzmann equation for a group of particles in the absence of collisions may be written df/dt = 0, where f is the distribution function in the phase space. This equation means that f is an individual motion constant. This leads to a study, of the paths and to a research of the first integrals of the differential system related to them. This study leads also to a confinement condition on the velocities of a particle. The following step is related to the theoretical study of some distribution functions and of the resulting consequences. A differential system is obtained, giving density and magnetic and electric fields. This system has been in a number of cases solved by a digital computer. This solution allows an experimental comparison to be made. The first integrals obtained are still valid when magnetic 'screw-type' fields are concerned, which results in the obtention of a type of helicoidal deformation and of a stability criteria with respect to these deformations. (author) [French] L'equation de Boltzmann pour un groupe de particules en l'absence de collision peut s'ecrire df/dt = 0, ou f est la fonction de distribution dans l'espace des phases. Cette equation signifie que f est une constante du mouvement individuel. On est donc amene a etudier les trajectoires et a rechercher des integrales premieres du systeme differentiel qui leur est lie; cette etude conduit aussi a une condition de confinement portant sur les vitesses d'une particule. L'etape suivante se rapporte a l'etude theorique de certaines fonctions de distribution et des consequences qui en decoulent. On arrive a un systeme differentiel donnant densite, champs magnetiques et electriques, systeme qui a ete resolu dans un certain nombre de cas par une machine a calculer digitale. Cette resolution permet une confrontation experimentale. Les integrales premieres obtenues restent encore valables lors de champs magnetiques en 'vis'; il en resulte l'obtention d'un type de deformation helicoidale et d

  3. Electron microscope study of vacancy clusters produced by quenching in magnesium; Etude par microscopie electronique des amas de lacunes crees par trempe dans le magnesium

    Energy Technology Data Exchange (ETDEWEB)

    Levy, V; Espinasse, J; Mairy, C; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Vacancy clustering in quenched magnesium has been studied by transmission electron microscopy. The nature of the vacancy loops observed, seems to depend essentially on the impurity content of the metal; this effect can be attributed to a variation of the stacking fault energy of magnesium due to impurities. (authors) [French] On a etudie par microscopie electronique en transmission les defauts crees par trempe dans le magnesium. Un effet considerable des impuretes du metal sur la nature des boucles obtenues par condensation de lacunes a ete mis en evidence; cet effet semble s'expliquer de facon satisfaisante par un abaissement de l'energie de faute d'empilement du magnesium du aux impuretes. (auteur)

  4. Lagrange formalism for a system of several fluids interacting electromagnetically; Formalisme lagrangien pour un systeme de plusieurs fluides en interaction electromagnetique

    Energy Technology Data Exchange (ETDEWEB)

    Vuillemin, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    After giving the Lagrange expression for a conducting fluid in an external electromagnetic field, the author shows that a Lagrange expression exists for describing the evolution of a system of interacting fluids obtained by adding the Lagrange expression of each fluid.to that of the electromagnetic field. By variation are obtained the fluid movement equation coupled to the Maxwell equations. It is shown that the study of small movements around a stationary state can be deduced from the Lagrange equation expanded to the second power order of the perturbation. It is then possible to deduce the normal mode equations and the study the stability by examining the modes which are marginally stable. (author) [French] Apres avoir rappele l'expression, du Lagrangien pour un fluide conducteur dans un champ electromagnetique exterieur, on montre qu'il existe un Lagrangien pour decrire l'evolution d'un systeme de fluides en.interaction que l'on obtient par la superposition du Lagrangien de chaque fluide et du Lagrangien du champ electromagnetique. On obtient par variation, les equations du mouvement des fluides, couplees aux equations de Maxwell. On montre que l'etude des petits mouvements autour d'un etat stationnaire se deduit du Lagrangien developpe au second1 ordre en puissance de la perturbation. On peut alors retrouver les equations des modes normaux et etudier la stabilite en recherchant les modes marginalement stables. (auteur)

  5. ParABS Systems of the Four Replicons of Burkholderia cenocepacia: New Chromosome Centromeres Confer Partition Specificity†

    Science.gov (United States)

    Dubarry, Nelly; Pasta, Franck; Lane, David

    2006-01-01

    Most bacterial chromosomes carry an analogue of the parABS systems that govern plasmid partition, but their role in chromosome partition is ambiguous. parABS systems might be particularly important for orderly segregation of multipartite genomes, where their role may thus be easier to evaluate. We have characterized parABS systems in Burkholderia cenocepacia, whose genome comprises three chromosomes and one low-copy-number plasmid. A single parAB locus and a set of ParB-binding (parS) centromere sites are located near the origin of each replicon. ParA and ParB of the longest chromosome are phylogenetically similar to analogues in other multichromosome and monochromosome bacteria but are distinct from those of smaller chromosomes. The latter form subgroups that correspond to the taxa of their hosts, indicating evolution from plasmids. The parS sites on the smaller chromosomes and the plasmid are similar to the “universal” parS of the main chromosome but with a sequence specific to their replicon. In an Escherichia coli plasmid stabilization test, each parAB exhibits partition activity only with the parS of its own replicon. Hence, parABS function is based on the independent partition of individual chromosomes rather than on a single communal system or network of interacting systems. Stabilization by the smaller chromosome and plasmid systems was enhanced by mutation of parS sites and a promoter internal to their parAB operons, suggesting autoregulatory mechanisms. The small chromosome ParBs were found to silence transcription, a property relevant to autoregulation. PMID:16452432

  6. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  7. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.

    Science.gov (United States)

    Fukushima, Henrique; Alves, Vanessa Tubero Euzebio; Carvalho, Verônica Franco de; Ambrósio, Lucas Macedo Batitucci; Eichler, Rosangela Aparecida Dos Santos; Carvalho, Maria Helena Catelli de; Saraiva, Luciana; Holzhausen, Marinella

    2017-01-26

    Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF) of patients with moderate chronic periodontitis (MP). The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19) at baseline, and from MP patients (n = 19) and severe chronic periodontitis (SP) (n = 19) patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA) in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR). PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  8. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  9. Do extra compulsory physical education lessons mean more physically active children - findings from the childhood health, activity, and motor performance school study Denmark (The CHAMPS-study DK)

    DEFF Research Database (Denmark)

    Møller, Niels; Tarp, Jakob; Kamelarczyk, Eva

    2014-01-01

    modifications by status of overweight/obesity and poor cardio-respiratory fitness are examined.MethodsParticipants were from the first part of the CHAMPS-study DK, which included approximately 1200 children attending the 0th ¿ 6th grade. At the sports schools, the mandatory physical education (PE) program...... schools and normal schools, respectively. However, children, especially boys, attending sports schools were more active during school time than children attending normal schools (girls: ß=51, p=0.065; boys: ß=113, p

  10. Confinement of a non cylindrical z discharge by a cusp geometry; Confinement d'une decharge lineaire non-cylindrique par une geometrie magnetique cuspidee

    Energy Technology Data Exchange (ETDEWEB)

    Watteau, J H [Commissariat a l' Energie Atomique, Limeil-Brevannes (France). Centre d' Etudes

    1968-03-01

    The plasma of a non-cylindrical z discharge is accumulated in the centre of a cusp geometry and then captured and confined by the rising cusp magnetic field. The cusp geometry is produced by two identical coaxial coils the currents of which are equal but in opposite directions. Stability and confinement properties of this zero minimum B geometry are recalled; in particular it is shown (the coils cross section being supposed punctual) that the magnetic well depth of the configuration without plasma is maximum for an optimum coils distance. Two modes of confinement are observed experimentally : - a collisional mode for which the plasma confinement is limited to 10 {mu}sec (temperature 5 eV, density 7 x 10{sup 16} cm{sup -3}) as a result of the gradual interpenetration of the plasma and of the magnetic field. - a collisionless mode (temperature 40 eV) where the radial leak thickness is of the order of the ion cyclotron radius. Plasma accumulation occurs even without confinement and is due to the non-cylindrical shape of the discharge chamber. The two-dimensional snow-plough model gives good account of the discharge dynamics. A comparison is made with plasma focus experiments: in particular experimental conditions (deuterium, pressure 1 torr,energy 3 kJ, current 100 kA) a 10{sup 7} neutron yield is detected which appears to be connected with the unstable behavior of the discharge. (authors) [French] Le plasma d'une decharge lineaire non-cylindrique s'accumule au centre d'une geometrie magnetique cuspidee ou il est capture et confine par l'induction croissante de la geometrie. On rappelle les proprietes de stabilite et de confinement de la geometrie cuspidee, geometrie a champ minimum nul produite par deux spires identiques, coaxiales et parcourues par des courants egaux et opposes; on montre en particulier que pour des spires de section ponctuelle la profondeur du puits magnetique de la geometrie sans plasma est maximum pour une distance optimum des spires. Deux

  11. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-11-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  12. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  13. Improved Satellite-based Photosysnthetically Active Radiation (PAR) for Air Quality Studies

    Science.gov (United States)

    Pour Biazar, A.; McNider, R. T.; Cohan, D. S.; White, A.; Zhang, R.; Dornblaser, B.; Doty, K.; Wu, Y.; Estes, M. J.

    2015-12-01

    One of the challenges in understanding the air quality over forested regions has been the uncertainties in estimating the biogenic hydrocarbon emissions. Biogenic volatile organic compounds, BVOCs, play a critical role in atmospheric chemistry, particularly in ozone and particulate matter (PM) formation. In southeastern United States, BVOCs (mostly as isoprene) are the dominant summertime source of reactive hydrocarbon. Despite significant efforts in improving BVOC estimates, the errors in emission inventories remain a concern. Since BVOC emissions are particularly sensitive to the available photosynthetically active radiation (PAR), model errors in PAR result in large errors in emission estimates. Thus, utilization of satellite observations to estimate PAR can help in reducing emission uncertainties. Satellite-based PAR estimates rely on the technique used to derive insolation from satellite visible brightness measurements. In this study we evaluate several insolation products against surface pyranometer observations and offer a bias correction to generate a more accurate PAR product. The improved PAR product is then used in biogenic emission estimates. The improved biogenic emission estimates are compared to the emission inventories over Texas and used in air quality simulation over the period of August-September 2013 (NASA's Discover-AQ field campaign). A series of sensitivity simulations will be performed and evaluated against Discover-AQ observations to test the impact of satellite-derived PAR on air quality simulations.

  14. Energie des particules émises après explosion coulombienne de l ...

    African Journals Online (AJOL)

    ةﺪﯾﺪﺷ ﺔﯿﻧﺎﺛﻮﺘﻤﻓ تارﺰﯿﻟ . Résumé. L'étude des clusters métalliques de Sodium (Na), contenant 5.103 atomes par agrégat, soumis à des champs laser femtosecondes intenses a conduit à une forte énergie d'excitation qui peut être l'origine des électrons de fortes énergies, des ions énergétiques de hautes charges ou des ...

  15. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  16. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

    2012-01-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  17. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G; Lewis, Mark; Juette, Arne; Cahir, John G; Toms, Andoni P [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  18. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  19. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  20. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Forman, Julie L

    2018-01-01

    -lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...

  2. Magnetic study of a few antiferromagnets in very-strong pulsed fields (450 kOE); Etude magnetique de quelques antiferromagnetiques dans des champs pulses tres intenses (450 k OE)

    Energy Technology Data Exchange (ETDEWEB)

    Krebs, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-01-01

    In this thesis we describe a pulsed field device with which we obtain magnetization curves up to 450 kOE at all temperatures between 1. 6 and 300. We have studied the 'spin-flopping'(and therefore the anisotropy) in MnF{sub 2} versus temperature, below the Neel point. We have also studied the antiferromagnets MnSO{sub 4}. and MnSO{sub 4}.H{sub 2}O which have revealed saturation fields respectively of 250 kOE and 320 kOE. (author) [French] Ce memoire est consacre a la fabrication et a la mise au point d'un appareillage utilisant la decharge d'une batterie de condensateurs, afin de faire des mesures d'aimantation en champs pulses jusqu'a 450 kOE a toute temperature entre 1,6 K et 300 K. Nous avons etudie le deplacement de la transition de 'spin-flopping' dans MnF{sub 2} en fonction de la temperature et nous en avons deduit la variation de la constante d'anisotropie en fonction de T au-dessous du point de Neel. Nous avons egalement fait l'etude magnetique des antiferromagnetiques MnSO{sub 4} et MnSO{sub 4}.H{sub 2}O et nous avons mis en evidence la saturation de ces deux substances pour des champs respectifs de 250 kOE et 320 kOE. (auteur)

  3. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  4. Efficacy and safety of the pars plana clip in the Ahmed valve device inserted via the pars plana in patients with refractory glaucoma

    Directory of Open Access Journals (Sweden)

    Manuel Diaz-Llopis

    2010-05-01

    Full Text Available Manuel Diaz-Llopis1,2,3, David Salom1,3, Salvador García-Delpech1,2,3, Patricia Udaondo1,3, Jose Maria Millan3,5, J Fernando Arevalo61Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain; 2Department of Ophthalmology of the Valencia University, Valencia, Spain; 3Biomedical Network Research Centre on Rare Diseases (CIBERER, Valencia, Spain; 4Catholic University San Vicente Martir, Valencia, Spain; 5Department of Genetics, La Fe University Hospital of Valencia, Valencia, Spain; 6Clinica Oftalmologica Centro Caracas, Retina and VItreous Service, Caracas, DC, VenezuelaPurpose: To evaluate the efficacy and safety of the pars plana clip (PPC in the Ahmed valve tube inserted via the pars plana in patients with secondary refractory glaucomas.Methods: Prospective and interventional case series that included 10 patients with secondary refractory glaucoma. The pars plana vitrectomy and the implant of the modified tube were performed during the same surgery. Control of intraocular pressure (IOP and the development of intra- and postoperative complications were evaluated during the follow-up.Results: Follow-up time was twelve months in all the patients. Control of IOP was achieved in 90% of patients, and 70% needed no antiglaucoma treatment. The complications that occurred were transient hypotony in three cases, choroidal detachment in two cases, and one case of intraocular hemorrhage. No case of tube extrusion or tube kink was observed.Conclusions: Our data suggests that implantation of the Ahmed tube modified with the PPC via the pars plana is safe and effective in patients with secondary refractory glaucomas. Keywords: pars plana clip, Ahmed valve, refractory glaucoma, pars plana vitrectomy

  5. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  6. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  8. Interfon

    CERN Multimedia

    Interfon

    2010-01-01

    En collaboration avec TMT Energies Nouvelles Nous vous invitons Le jeudi 6 mai à 18h00 au Business center (Technoparc de St-Genis-Pouilly)   à une présentation d’un nouveau système de Chauffage par Ionisation   Ce nouveau système de chauffage peut chauffer une maison ou un appartement de 100 m2 pour moins de 400 euros par an et offre les avantages suivants : Il est parmi les plus petits du marché et peut aussi bien équiper des installations individuelles que des petites collectivités Ne fonctionne que sur des émetteurs de chaleurs à eau (radiateurs ou planchers chauffants) Ne dégage aucune émanation ni champ magnétique. Aucun risque d’incident, pas de pollution par rejet de fumées ou de matières nocives. Est conçu de telle sorte que le risque de panne est totalement nul , avec un...

  9. Solidarité

    CERN Multimedia

    Jean-Pierre Lagnaux, Secrétaire général

    2011-01-01

    Éducation et Libération   Vente de printemps au bénéfice des populations sinistrées du Togo et du Bénin Mercredi 13 et jeudi 14 avril Bâtiment principal   A l’automne 2010, le sud du Togo et du Bénin a été submergé par des pluies exceptionnellement fortes. Éducation et Libération soutient dans le sud de ces deux pays, des programmes de formation scolaire et professionnelle qui ont subi les effets dévastateurs de ces pluies. Ces programmes comportent aussi un volet agricole par la mise en valeur de 13 hectares plantés en maïs, manioc et ananas bio au Bénin et par l’élevage de lapins dans les deux pays et de poules pondeuses au Togo. Écoles, ateliers, champs ont subi des dégâts mais aussi les habitations des familles, les chemins et les routes. Votre ...

  10. Solidarity

    CERN Multimedia

    Jean-Pierre Lagnaux, Secrétaire général

    2011-01-01

    Éducation et libération Vente au bénéfice des populations du Togo et du Bénin Lundi 14 et mardi 15 novembre Bâtiment principal Il y a un an, le sud du Togo et du Bénin a été submergé par des pluies exceptionnellement fortes. Éducation et Libération soutient dans le sud de ces deux pays, des programmes de formation scolaire et professionnelle qui ont subi les effets dévastateurs de ces pluies. Ces programmes comportent aussi un volet agricole par la mise en valeur de 13 hectares plantés en maïs, manioc et ananas bio au Bénin et par l’élevage de lapins dans les deux pays et de poules pondeuses au Togo. Écoles, ateliers, champs ont subi des dégâts mais aussi les habitations des familles, les chemins et les routes. Votre appui sera précieux pour que nos amis puissent retrouve...

  11. Solidarité

    CERN Multimedia

    Staff Association

    2010-01-01

    Vente de Noël au bénéfice des populations sinistrées du Togo et du Bénin    Appel d’Éducation et Libération Mardi 23 et Mercredi 24 novembre Depuis septembre, le sud du Togo et du Bénin est submergé par des pluies exceptionnellement fortes. Éducation et Libération soutient dans le sud de ces deux pays, des programmes de formation scolaire et professionnelle qui subissent les effets dévastateurs de ces pluies. Ces programmes comportent aussi un volet agricole par la mise en valeur de 13 hectares plantés en maïs, manioc et ananas bio au Bénin et par l’élevage de lapins dans les deux pays et de poules pondeuses au Togo. Écoles, ateliers, champs ont subi des dégâts mais aussi les habitations des familles, les chemins et les routes. Votre appui sera précieux...

  12. [Ambroise Paré, his death and his historians].

    Science.gov (United States)

    Dumaître, P

    2001-01-01

    Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.

  13. Bacterial mitosis: Partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, G.; Gerdes, Kenn

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells......A-GFP oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...

  14. Modélisation du procédé de soudage hybride Arc / Laser par une approche level set application aux toles d'aciers de fortes épaisseurs A level-set approach for the modelling of hybrid arc/laser welding process application for high thickness steel sheets joining

    Directory of Open Access Journals (Sweden)

    Desmaison Olivier

    2013-11-01

    Full Text Available Le procédé de soudage hybride Arc/Laser est une solution aux assemblages difficiles de tôles de fortes épaisseurs. Ce procédé innovant associe deux sources de chaleur : un arc électrique produit par une torche MIG et une source laser placée en amont. Ce couplage améliore le rendement du procédé, la qualité du cordon et les déformations finales. La modélisation de ce procédé par une approche Level Set permet une prédiction du développement du cordon et du champ de température associé. La simulation du soudage multi-passes d'une nuance d'acier 18MnNiMo5 est présentée ici et les résultats sont comparés aux observations expérimentales. The hybrid arc/laser welding process has been developed in order to overcome the difficulties encountered for joining high thickness steel sheets. This innovative process gathers two heat sources: an arc source developed by a MIG torch and a pre-located laser source. This coupling improves the efficiency of the process, the weld bead quality and the final deformations. The Level-Set approach for the modelling of this process enables the prediction of the weld bead development and the temperature field evolution. The simulation of the multi-passes welding of a 18MnNiMo5 steel grade is detailed and the results are compared to the experimental observations.

  15. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  16. Performance Analysis of Compositional and Modified Black-Oil Models For a Gas Lift Process Analyse des performances de modèles black-oil pour le procédé d’extraction par injection de gaz

    Directory of Open Access Journals (Sweden)

    Mahmudi M.

    2013-03-01

    Full Text Available Artificial gas lift is frequently used to boost production rate of mature oil fields. An integrated mathematical model was developed in order to track the spatial and temporal changes in various components of the continuous gas lift process. The computational demand for solving the comprehensive gas lift model highly depends on the thermodynamic treatment of the hydrocarbon fluids involved. A full compositional treatment using an equation of state provides the most accurate results but at a high computational cost. The results of this article showed that the computational cost can be halved without sacrificing accuracy by using reduced parameter stability and flash calculation procedures. It was also demonstrated that a Modified Black-Oil treatment of the fluids can provide reasonable accuracy at a much-reduced computational cost. The Modified Black-Oil treatment provides a valuable tool when the model has to be solved many hundreds of times to find the optimal combination of the gas lift parameters. Les procédés artificiels d’extraction par injection de gaz sont utilisés pour améliorer le taux de récupération des champs pétroliers matures. Un modèle mathématique intégré a été développé pour détecter de faibles changements temporels et spatiaux dans plusieurs composants des procédés continus d’extraction par injection de gaz. La solution numérique utilisée pour résoudre le modèle du procédé d’extraction dépend fortement du comportement thermodynamique des hydrocarbures impliqués. Un traitement complet de la composition utilisant une équation d’état offre les résultats les plus précis, mais à un coût de calcul très élevé. Les résultats de nos travaux de recherche montrent que l’implication des paramètres de stabilité et des procédures de calcul flash, peut diviser par deux le coût du calcul tout en gardant la précision attendue. Ces travaux montrent que la précision admissible peut être

  17. First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Science.gov (United States)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369

  18. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis

    International Nuclear Information System (INIS)

    Gianoulakis, C.; Seidah, N.G.; Routhier, R.; Chretien, M.

    1980-01-01

    Rats pars intermedia cells were incubated for 3 h with the following amino-acids: a) 35 S-methionine and 3 H-phenylalamine; b) 3 H-valine; and c) 3 H-valine and 3 H-lysine. Radioactive gamma-lipotropin, beta-lipotropin and beta-endorphin were purified on carboxy- methyl-cellulose and characterized by polyacrylamide disc gel electrophoresis af pH 4.5, molecular weight estimation and microsequencing. Rat gamma-lipotropin was shown to differ slightly from ovine gamma-lipotropin in its NH 2 -terminal amino acid sequence, in containing no methionine and having phenylalanine at position 6, valine at positions 13 and 27, and lysine at position 20. The same variations were observed in the sequence of rat beta-lipotropin, while rat beta-endorphin was shown to be identical to the ovine beta-endorphin. Following a 3-h pulse of rat pars distalis, the cells were extracted with care to avoid beta-lipotropin degradation by proteolytic enzymes. A peptide was purified and identified to be rat beta-endorphin, thus demonstrating that beta-endorphin is biosynthesized in pars distalis and is not an extraction artifact. (author)

  19. Fonction et signe de l'arbre dans l'espace urbain de Lomé

    OpenAIRE

    Tchamie, T.T.K.; Badameli, M.K.

    1998-01-01

    Le monde végétal est inscrit naturellement dans la conscience des population africaines. Il n'est donc pas étonnant que l'arbre soit omniprésent dans les champs et les agglomérations. Cette présence de l'arbre s'explique par son importance dans la vie des hommes : rôle alimentaire aussi bien pour les hommes que pour les animaux, rôle réligieux, rôle écologique, rôle énergétique...

  20. Femmes, genre et violence

    OpenAIRE

    Castan-Vicente, Florys; Benevent, Laurie

    2016-01-01

    Le présent article s’attache à comparer deux ouvrages sur la violence et les femmes, parus à quinze ans d’intervalle : De la violence et des femmes (1997) et Penser la violence des femmes (2012). Il s’agira de dégager de cette comparaison des conclusions sur l’évolution, entre ces deux dates, de ce champ d’étude, très neuf lors de la parution du premier ouvrage, et ayant connu un développement important par la suite.

  1. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  2. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    on Par3. Functionally, this mechanism impacts on tight junction downregulation. Furthermore, SIK contributes to the loss of epithelial polarity and examination of advanced and invasive human cancers of diverse origin displayed high levels of SIK expression and a corresponding low expression of Par3...

  3. Efficacité d'un exutoire de dévalaison et d'une barrière acoustique pour les smolts de saumon atlantique (Salmo salar L. à l'aménagement hydroélectrique de St. Cricq sur le gave d'Ossau.

    Directory of Open Access Journals (Sweden)

    TRAVADE F.

    1999-04-01

    Full Text Available Une expérimentation a été conduite en 1996 au niveau de l'aménagement hydroélectrique de St. Cricq (gave d'Ossau dans le but de tester deux dispositifs de dévalaison destinés à éviter le passage dans les turbines des smolts de saumon atlantique (Salmo sala L.. Le premier, localisé au barrage, consiste en une barrière acoustique répulsive destinée à détourner les smolts vers un clapet de décharge. Le champ sonore, généré par 16 émetteurs immergés, est dans la gamme de fréquence 100-600 Hz avec un niveau sonore maximal de 120-130 dB. Le deuxième dispositif, localisé à l'usine, consiste en un exutoire de surface situé en rive, à proximité immédiate de la grille de prise d'eau. L'efficacité des deux dispositifs a été évaluée par marquage-recapture et le comportement des smolts a été suivi par radiotélémétrie. Les passages de smolts par le clapet du barrage varient de 20 % à 60 % ; cette efficacité résulte essentiellement du débit élevé transitant par le clapet. Les tests effectués avec et sans barrière acoustique n'ont mis en évidence aucun effet significatif du champ sonore. L'efficacité de l'exutoire du bassin de mise en charge est d'environ 80 %. La faible largeur de la prise d'eau (11 m, le faible espacement des barreaux de la grille de prise d'eau (2,5 cm, les conditions hydrauliques devant la grille qui guident rapidement les poissons vers l'entrée de l'exutoire, et la configuration de l'entrée de l'exutoire qui crée un écoulement à faible gradient de vitesse peuvent expliquer l'efficacité élevée de ce dispositif.

  4. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma...... and prognostic imaging method. In this review, we will focus on the recent development of uPAR PET and the relevance within prostate cancer imaging. Novel antibody and small-molecule radiotracers-targeting uPAR, including a series of uPAR-targeting PET ligands, based on the high affinity peptide ligand AE105......, have been synthesized and tested in vitro and in vivo in preclinical murine xenograft models and, recently, in a first-ever clinical uPAR PET study in cancer patients, including patients with PC. In this phase I study, a high and specific uptake of the tracer 64Cu-DOTA-AE105 was found in both primary...

  5. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway

    International Nuclear Information System (INIS)

    Li, Taiyuan; Liu, Dongning; Lei, Xiong; Jiang, Qunguang

    2017-01-01

    Partitioning defective 3-like protein (Par3L) is a recently identified cell polarity protein that plays an important role in mammary stem cell maintenance. Previously, we showed that high expression of Par3L is associated with poor survival in malignant colorectal cancer (CRC), but the underlying mechanism remained unknown. To this end, we established a Par3L knockout colorectal cancer cell line using the CRISPR/Cas system. Interestingly, reduced proliferation, enhanced cell death and caspase-3 activation were observed in Par3L knockout (KO) cells as compared with wildtype (WT) cells. Consistent with previous studies, we showed that Par3L interacts with a tumor suppressor protein liver kinase B1 (Lkb1). Moreover, Par3L depletion resulted in abnormal activation of Lkb1/AMPK signaling cascade. Knockdown of Lkb1 in these cells could significantly reduce AMPK activity and partially rescue cell death caused by Par3L knockdown. Furthermore, we showed that Par3L KO cells were more sensitive to chemotherapies and irradiation. Together, these results suggest that Par3L is essential for colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway, and is a putative therapeutic target for CRC. - Highlights: • Par3L knockout using the CRISPR/Cas system induces apoptosis in colorectal cancer cells. • Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. • Par3L knockout cells are more sensitive to treatment of different chemotherapy drugs and irradiation.

  6. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  7. Brief communication: Population variation in human maxillary premolar accessory ridges (MxPAR).

    Science.gov (United States)

    Burnett, Scott E; Hawkey, Diane E; Turner, Christy G

    2010-02-01

    The purpose of this brief communication is to report the results of an analysis of maxillary premolar accessory ridges (MxPAR), a common but understudied accessory ridge that may occur both mesial and distal to the central ridge of the buccal cusp of upper premolars. We developed a new five-grade scoring plaque to better categorize MxPAR variation. Subsequently, we conducted a population analysis of MxPAR frequency in 749 dental casts of South African Indian, American Chinese, Alaskan Eskimo, Tohono O'odham (Papago), Akimel O'odham (Pima), Solomon Islander, South African Bantu, and both American and South African Whites. Northeast Asian and Asian-derived populations exhibited the highest MxPAR frequencies while Indo-European samples (South African Indians, American and South African Whites) exhibited relatively low frequencies. The Solomon Islanders and South African Bantu samples exhibited intermediate frequencies. Our analysis indicates that statistically significant differences in MxPAR frequency exist between major geographic populations. As a result, the MxPAR plaque has now been added to the Arizona State University Dental Anthropology System, an important contribution as maxillary premolar traits are underrepresented in analyses of dental morphology. 2009 Wiley-Liss, Inc.

  8. Intoxication par la paraphényléne-diamine

    African Journals Online (AJOL)

    raoul

    9 mars 2011 ... remède contre la douleur par Averbukh [8], ou contre la constipation par Schemesh [9], mais l´utilisation à des fins autolytique reste toujours prédominante. Le tableau clinique de l´intoxication à ... une anurie ayant nécessité le recours à l´hémodialyse. Ce taux de survenue d´IRA anurique est relativement ...

  9. Study of the properties of an electron linac beam by means of the electromagnetic fields associated with the beam; Etude des proprietes du faisceau d'electrons d'un accelerateur lineaire au moyen des champs electromagnetiques associes a ce faisceau

    Energy Technology Data Exchange (ETDEWEB)

    Bergere, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    For measuring the diverse characteristic parameters of a Linac electron beam, the one method causing the least perturbation to the electron beam itself, consists in the detection of signals induced in certain types of detectors by the electromagnets fields associated with the beam. Some particular detectors are then described, for measuring the following characteristic parameters of a Linac electron beam; a) electron beam peak current, a) longitudinal dimension and density of an elementary electron bunch, c) phase position of the electrons on the travelling sine wave of the accelerating field, d) transverse position of the beam. These particular electrodes are then used to provide experimental data In order to check the theoretical computations giving the longitudinal and transversal motions Of the electrons during their acceleration. (author) [French] Parmi les methodes de mesure des diverses caracteristiques du faisceau d'electrons d'un accelerateur lineaire, celles qui perturbent le moins le faisceau sont les methodes dans lesquelles l'energie du signal de mesure provient de la perturbation par l'electrode de mesure des champs electromagnetiques associes au faisceau. On decrit les electrodes de ce type qui ont ete mises au point pour mesurer les caracteristiques suivantes du faisceau d'electrons: a) courant crete, b) extension en phase d'un paquet elementaire d'electrons, c) phase d'accrochage des electrons, d) position transversale moyenne des electrons. On decrit ensuite comment les signaux provenant de ces diverses electrodes peuvent etre utilises pour verifier experimentalement les previsions theoriques des mouvements longitudinaux et transversaux des electrons en cours d'acceleration. (auteur)

  10. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  11. par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

    Directory of Open Access Journals (Sweden)

    Casart Yveth

    2008-03-01

    Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.

  12. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

    2005-01-01

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  13. Prognostic value of suPAR and hs-CRP on cardiovascular disease

    DEFF Research Database (Denmark)

    Diederichsen, Marie Zöga; Diederichsen, Søren Zöga; Mickley, Hans

    2018-01-01

    Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP...... have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events...

  14. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.

    Science.gov (United States)

    Hau, Andrew M; Leivo, Mariah Z; Gilder, Andrew S; Hu, Jing-Jing; Gonias, Steven L; Hansel, Donna E

    2017-01-01

    Mammalian target of rapamycin complex 2 (mTORC2) has been identified as a major regulator of bladder cancer cell migration and invasion. Upstream pathways that mediate mTORC2 activation remain poorly defined. Urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored membrane protein and known activator of cell-signaling. We identified increased uPAR expression in 94% of invasive human bladder cancers and in 54-71% of non-invasive bladder cancers, depending on grade. Normal urothelium was uPAR-immunonegative. Analysis of publicly available datasets identified uPAR gene amplification or mRNA upregulation in a subset of bladder cancer patients with reduced overall survival. Using biochemical approaches, we showed that uPAR activates mTORC2 in bladder cancer cells. Highly invasive bladder cancer cell lines, including T24, J82 and UM-UC-3 cells, showed increased uPAR mRNA expression and protein levels compared with the less aggressive cell lines, UROtsa and RT4. uPAR gene-silencing significantly reduced phosphorylation of Serine-473 in Akt, an mTORC2 target. uPAR gene-silencing also reduced bladder cancer cell migration and Matrigel invasion. S473 phosphorylation was observed by immunohistochemistry in human bladder cancers only when the tumors expressed high levels of uPAR. S473 phosphorylation was not controlled by uPAR in bladder cancer cell lines that are PTEN-negative; however, this result probably did not reflect altered mTORC2 regulation. Instead, PTEN deficiency de-repressed alternative kinases that phosphorylate S473. Our results suggest that uPAR and mTORC2 are components of a single cell-signaling pathway. Targeting uPAR or mTORC2 may be beneficial in patients with bladder cancer. Copyright © 2016. Published by Elsevier Inc.

  15. Traduire la bêtise. Entretien avec Hans-Horst Henschen

    Directory of Open Access Journals (Sweden)

    Hans-Horst Henschen

    2012-03-01

    Full Text Available Quand il entreprend de traduire l’ensemble du corpus Bouvard et Pécuchet, Hans-Horst Henschen est déjà un traducteur reconnu. Ses traductions et/ou éditions de Barthes, Lévi-Strauss, Lyotard, Althusser, Michel Serres ou Jean Starobinski font de lui en Allemagne un relais important de la pensée française. Et à ces traductions d’auteurs ou de courants critiques, s’ajoutent celles qui s’y rattachent par raccroc ; celles qui semblent au contraire quitter les champs de l’anthropologie, de la psych...

  16. Procédés linguistiques et stratégies discursives des médias en Algérie. Cas de l’émission algérienne« Hwalenas » de la chaîneDzair TV Etude Sociolinguistique

    OpenAIRE

    ABBACI, Sarra Fatima

    2015-01-01

    L’Algérie connait un plurilinguisme de fait qui ne cesse de marquer les usages quotidiens de tous les Algériens. Le plurilinguisme en question se traduit par la coexistence de l’arabe standard, l’arabe dialectal, Tamazight et le français. Cette réalité n’est pas en conformité avec les principes de la constitution algérienne qui disqualifie les langues maternelles etpasse sous silence le plurilinguisme existant. Or, l’éclatement du champ médiatique en Algérie, dans les années 90...

  17. Introduction \\`a la Physique Quantique

    OpenAIRE

    Piron, Constantin

    2002-01-01

    En nous laissant guider par la notion de champ qui en fait domine toute la physique nous d\\'efinissons la nature physique d'un syst\\`eme, ses propri\\'et\\'es et ses \\'etats possibles. Nous proposons alors un cadre tr\\`es g\\'en\\'erale permettant la description de tels syst\\`emes et la construction de mod\\`eles consistants. Nous en donnons des exemples et pour illustrer les concepts de notre th\\'eorie nous d\\'ecrivons diff\\'erents types d'\\'evolutions. Pour terminer nous discutons en d\\'etails u...

  18. David J. Stuart-Fox, Pura Besakih. Temple, Religion and Society in Bali

    OpenAIRE

    Guillot, Claude

    2005-01-01

    Bali constitue une exception dans le monde insulindien auquel il appartient. Alors que les autres îles ont très majoritairement adopté l'islam et quelques-unes le christianisme, Bali a préservé son héritage « hindouiste » au point de passer, en grande partie à tort, pour un conservatoire de la civilisation javanaise antérieure à l'islamisation. Ce particularisme se traduit dans le paysage par une profusion de temples et templions qui rythment l'horizon des villes, des villages et des champs e...

  19. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  20. La Dialectique autonomie / contrôle dans le management par projet

    Directory of Open Access Journals (Sweden)

    Nathalie Lapayre

    2009-10-01

    Full Text Available Beaucoup a été écrit au cours des dernières années sur les nouvelles formes d’organisation du travail (NFOT, et sur ce à quoi pourrait ressembler une organisation post bureaucratique ; une grande partie de ces écrits tendraient à laisser croire que nos organisations se sont débarrassées de leurs vieux habits du taylorisme et de la bureaucratie, et sont devenues aujourd’hui un lieu de bien-être pour les salariés, un lieu d’épanouissement, d’apprentissage, voire d’émancipation. Les diverses enquêtes réalisées concernant l’évolution des conditions de travail, de l’autonomie, de la participation, montrent une image beaucoup plus contrastée et ambigüe. Poursuivant cette réflexion, nous avons voulu nous intéresser à une NFOT qui nous apparaît comme particulièrement productive d’autonomie et de liberté pour les acteurs : l’organisation par projets. Nous nous sommes penchés sur l’étude des modes de contrôle, dans ces formes modernes d’organisation du travail, qui visent tantôt à contrôler les acteurs, afin de respecter les contraintes du projet, tantôt à leur laisser un maximum de champ libre en vue de libérer les énergies créatrices. Cet article livre les questionnements qui émergent de la revue de la littérature sur le sujet et qui conduisent à se demander si les processus de contrôle mis en place dans ces organisations ne seraient pas à rapprocher des systèmes de surveillance, voire de Gouvernementalité qu’avait développés, en son temps, M. Foucault.This paper adresses the issue of the new forms of work organization and questions the issue of the post-bureaucratic organization, particularly the idea that workplaces have gone beyond taylorism and bureaucracy and have become a place where workers learn and develop themselves. The reality appears more nuanced. The author looks into the specific form of work organization, which is work by project, its modes of control of actos in

  1. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.......Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  2. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  3. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  4. Complexation de l'aluminium par des hétéropolyanions lacunaires ...

    African Journals Online (AJOL)

    L'objectif visé par cette étude est la dépollution des eaux à partir de la complexation d'un métal toxique, l'aluminium en solution, par des hétéropolyanions lacunaires (HPA) de type Dawson. Les complexes formés sont récupérés par membrane liquide émulsionnée (MEL).Les résultats de la complex1ation de l'aluminium ...

  5. Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb.

    Science.gov (United States)

    Schenk, Heiko; Müller-Deile, Janina; Schmitt, Roland; Bräsen, Jan Hinrich; Haller, Hermann; Schiffer, Mario

    2017-12-01

    Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant. © 2017 Wiley Periodicals, Inc.

  6. Thrombin induces rapid PAR1-mediated non-classical FGF1 release

    International Nuclear Information System (INIS)

    Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

    2006-01-01

    Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis

  7. Systemes Fermioniques a Basse Dimension D'espace: Supraconductivite, Effet Hall Quantique et Statistique Fractionnaire

    Science.gov (United States)

    Sakhi, Said

    Cette these est constituee de trois sujets de recherche distincts. Les deux premiers articles traitent du phenomene de supraconductivite dans un modele bidimensionnel, dans le troisieme article on etudie l'action effective d'un systeme electronique soumis a l'effet d'un champ magnetique (systeme de Hall) et le dernier article examine la quantification d'un systeme de particules identiques en deux dimensions d'espace et la possibilite des anyons. Le modele qu'on analyse dans les deux premiers articles est un systeme fermionique dont les particules chargees et de masse nulle interagissent entre elles avcc un couplage attractif et fort. L'analyse de l'action effective decrivant la physique a basse energie nous permet d'examiner la structure de l'espace de phase. A temperature nulle, le parametre d'ordre du systeme prend une valeur moyenne non nulle. Consequemment, la symetrie continue U(1) du modele est spontanement brisee et il en resulte l'apparition d'un mode de Goldstone. En presence d'un champ electromagnetique externe, ce mode disparait et le champ de jauge acquiert une masse donc l'effet Meissner caracteristique d'un supraconducteur. Bien que le modele ne soit pas renormalisable dans le sens perturbatif, on montre qu'il l'est dans le cadre du developpement en 1/N ou N est le nombre d'especes fermioniques. En outre, on montre que l'inclusion des effets thermiques change radicalement le mecanisme de supraconductivite. En effet, on montre que la brisure spontanee de la symetrie U(1) n'est plus possible a temperature finie a cause de tres severes divergences infrarouges. Par contre, la dynamique des tourbillons (vortex) existant dans le plan devient essentielle. On montre que le phenomene de supraconductivite resulte du confinement de ces objets topologiques et que la temperature critique s'identifie a celle de Kosterlitz -Thouless. Ce mecanisme de supraconductivite presente l'avantage d'aboutir a un rapport gap a la temperature critique plus eleve que celui du

  8. Examining relational empowerment for elementary school students in a yPAR program.

    Science.gov (United States)

    Langhout, Regina Day; Collins, Charles; Ellison, Erin Rose

    2014-06-01

    This paper joins relational empowerment, youth empowerment, and Bridging Multiple Worlds frameworks to examine forms of relational empowerment for children in two intermediary institutions-school and a youth participatory action research after-school program (yPAR ASP). Participants were twelve children, most of whom were Latina/o and from im/migrant families, enrolled in a yPAR ASP for 2 years. A mixed-method approach was utilized; we analyzed children's interviews, self-defined goals, and their social networks to examine their experiences of relational empowerment. We conclude that children experienced each of the five relational empowerment factors-collaborative competence, bridging social divisions, facilitating others' empowerment, mobilizing networks, and passing on a legacy-in the yPAR ASP setting, and some factors in school. These experiences, however, were more pronounced in the yPAR ASP setting. Additionally, social network analyses revealed that a small but meaningful percentage of actors bridged worlds, especially home and family, but by year 2, also school and the yPAR ASP. Finally, most helpers for school-based goals came from school, but a sizable number came from family, friends, and home worlds, and by year 2, also came from the yPAR ASP. Implications range from theoretical to methodological development, including the use of social network analysis as a tool to descriptively examine relational power in context.

  9. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W

    2011-01-01

    The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections...... are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after...... the first positive blood culture for S. aureus, suPAR levels were higher in 19 fatalities (median 12.3; range 5.7-64.6 ng/mL) than in 40 survivors (median 8.4; range 3.7-17.6 ng/mL, p = 0.002). This difference persisted for 10 days. The presence of deep infection focus was not associated with elevated su...

  10. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  11. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    International Nuclear Information System (INIS)

    Homma, Taihei; Shimizu, Miho; Kuroda, Reiko

    2011-01-01

    Research highlights: → The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. → L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. → Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  12. Results obtained from the 'Bille en tete A' Experiment. Part 1. Collisions in homogeneous magnetic field. Part 2. Collisions in magnetic mirror bottle; Resultats experimentaux sur bille en tete 'A'. Partie I: Collisions en champ magnetique homogene. Partie II: Collisions en bouteille magnetique a miroir

    Energy Technology Data Exchange (ETDEWEB)

    Evrard, P; Jacquinot, J; Leloup, C; Poffe, J -P; Waelbroeck, F

    1966-07-01

    . (authors) [French] Partie I: Collisions en champ magnetique homogene. Nous etudions, dans un champ magnetique longitudinal et uniforme, la collision de bouffees de plasma dont les caracteristiques de vitesse et de densite couvrent un large domaine. Apres avoir verifie que les bouffees se rencontrent de plein fouet, nous montrons que les collisions de bouffees denses (n{sub i} >= 4.10{sup 14} cm{sup -3}) et relativement lentes (V{sub 0} <= 10{sup 7} cm.s{sup -1}) sont efficaces et qu'on retrouve pratiquement toute l'energie cinetique initiale des bouffees en energie thermique ionique du plasma arrete. Les bouffees plus rapides et moins denses interagissent peu: conversion incomplete d'energie cinetique en energie thermique. La limite entre collisions efficaces et inefficaces correspond a celle qu'on attend en utilisant le modele des particules temoins. Ce sont donc les collisions entre particules qui assurent le freinage des bouffees. L'emploi des sondes electriques et l'etude de l'evolution du plasma forme par collision montrent que ce dernier ne manifeste pas de mouvements radiaux importants. Partie II: Collisions en bouteille magnetique a miroir. Dans la bouteille magnetique de Bille-en-Tete A (B{sub c}entre = 2000 G, R = 2), la collision de 2 bouffees peu denses a permis de pieger un litre de plasma dont la densite n{sub i} vaut 2.10{sup 13} cm{sup -3} et la temperature ionique Ti = 106 K. Le diamagnetisme de ce plasma persiste pendant 50 a 150 {mu}s et on ne decele pas d'instabilites en flutes. L'evolution de T{sub i} a ete mesuree par effet Doppler sur la raie 4686 Angstrom de He'+ (melange a 5 pour cent au D{sup +} injecte) et l'evolution relative de n{sub i} par l'intensite du fond continu spectral T{sub i} decroit rapidement, atteint 5.10'5 et 10'5 K, respectivement 15 et 120 {mu}s apres le maximum du signal diamagnetique de la collision. n{sub i} croit lentement de 25 pour cent pendant les 100 premieres {mu}s apres la collision. La presence de plasma froid

  13. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  14. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  15. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  16. Contribution to the Study of Nuclear Magnetic Resonance in Ferromagnets; Contribution a l'etude de la resonance nucleaire dans les corps ferromagnetiques

    Energy Technology Data Exchange (ETDEWEB)

    Robert, C. [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

    1962-07-01

    Properties of nuclear magnetic resonance in the field acting on the nucleus in a ferromagnet were studied. Nuclei were {sup 57}Fe in iron and yttrium iron garnet. Static properties of resonance (frequency, line-width, dipolar structure) were investigated and compared with magnetic behavior and magnetic structure of the materials. Relaxation in garnet points out importance of long range fluctuations induced by impurities in a ferromagnetic lattice. (author) [French] Nous avons etudie les proprietes de la resonance nucleaire dans le champ existant a remplacement d'un noyau dans un corps ferromagnetique (champ local). Les noyaux etaient ceux de {sup 57}Fe dans le fer et dans le grenat d'yttrium et de fer. Les proprietes statiques de la resonance (frequence de resonance, largeur de la raie, structures dues a l'interaction dipolaire) ont ete etudiees et reliees aux caracteristiques magnetiques et a la structure de ces corps. La relaxation dans le grenat a mis en evidence les fluctuations a longue distance induites par des impuretes dans un reseau ferromagnetique. (auteur)

  17. Contribution to the Study of Nuclear Magnetic Resonance in Ferromagnets; Contribution a l'etude de la resonance nucleaire dans les corps ferromagnetiques

    Energy Technology Data Exchange (ETDEWEB)

    Robert, C [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

    1962-07-01

    Properties of nuclear magnetic resonance in the field acting on the nucleus in a ferromagnet were studied. Nuclei were {sup 57}Fe in iron and yttrium iron garnet. Static properties of resonance (frequency, line-width, dipolar structure) were investigated and compared with magnetic behavior and magnetic structure of the materials. Relaxation in garnet points out importance of long range fluctuations induced by impurities in a ferromagnetic lattice. (author) [French] Nous avons etudie les proprietes de la resonance nucleaire dans le champ existant a remplacement d'un noyau dans un corps ferromagnetique (champ local). Les noyaux etaient ceux de {sup 57}Fe dans le fer et dans le grenat d'yttrium et de fer. Les proprietes statiques de la resonance (frequence de resonance, largeur de la raie, structures dues a l'interaction dipolaire) ont ete etudiees et reliees aux caracteristiques magnetiques et a la structure de ces corps. La relaxation dans le grenat a mis en evidence les fluctuations a longue distance induites par des impuretes dans un reseau ferromagnetique. (auteur)

  18. Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

    Directory of Open Access Journals (Sweden)

    F. de la Torre Silva

    2008-01-01

    Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.

  19. Contamination potentielle des aliments par des ...

    African Journals Online (AJOL)

    SARA Computers

    la notion de la pollution et de l'exposition aux PCBs, lorsque 77% n'ont pas conscience de cette situation de risque ... 2018). Quoique la contamination par les. PCBs soit de faible niveau, elle est ...... Université Paris-Est, Paris, France ; 183.

  20. Prediction under Uncertainty on a Mature Field Prévision de production sous incertitude pour un champ mature

    Directory of Open Access Journals (Sweden)

    Feraille M.

    2012-04-01

    champ mature considéré est le modèle de réservoir PUNQS qui a été utilisé auparavant dans plusieurs études comparatives de quantification d’incertitudes et de calage d’historique. Une méthodologie basée sur trois étapes est proposée et appliquée au cas PUNQS. Tout d’abord, une sélection et une analyse de sensibilité ont été réalisées afin de déterminer les paramètres d’entrée incertains les plus influents. Puis, dans une seconde étape, une méthode d’inversion probabiliste a été utilisée afin de réduire l’incertitude sur les paramètres en estimant leur incertitude a posteriori. Enfin, des prédictions probabilistes au-delà des données d’historique sont calculées en propageant les incertitudes a posteriori des paramètres. Au cours de la première étape, deux techniques d’analyse de sensibilité sont proposées et comparées. L’une, qualitative, basée sur la méthode Morris et une autre, plus quantitative, basée sur les indices de Sobol. Au cours de la deuxième étape, une procédure de calage probabiliste est utilisée afin de réduire l’incertitude. La méthode proposée repose sur une modélisation par surface de réponse non paramétrique de type processus gaussien et sur une stratégie de planification adaptative. Dans la dernière étape, des surfaces de réponse paramétriques sont utilisées afin de modéliser les prévisions de production de réservoir et obtenir leur répartition probabiliste en propageant l’incertitude a posteriori des paramètres d’entrée.

  1. Accouchement par césarienne et mortalité maternelle du postpartum

    OpenAIRE

    Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

    2006-01-01

    Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

  2. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  3. Electromagnetic properties of a modular MHD thruster

    Science.gov (United States)

    Kom, C. H.; Brunet, Y.

    1999-04-01

    The magnetic field of an annular MHD thruster made of independent superconducting modules has been studied with analytical and numerical methods. This configuration allows to obtain large magnetized volumes and high induction levels with rapidly decreasing stray fields. When some inductors are out of order, the thruster remains still operational, but the stray fields increase in the vicinity of the failure. For given structural materials and superconductors, it is possible to determine the size of the conductor in order to reduce the electromagnetic forces and the peak field supported by the conductors. For an active field of 10 T in a 6 m ray annular active channel of a thruster with 24 modules, the peak field is exactly 15.6 T in the Nb3Sn conductors and the structure has to sustain 10^8 N/m forces. The necessity to place some magnetic or superconducting shield is discussed, particularly when the thruster is in a degraded regime. Nous présentons une étude analytique et numérique du champ magnétique d'un propulseur MHD naval annulaire, constitué de secteurs inducteurs supraconducteurs. Cette configuration nécessite des champs magnétiques élevés dans des volumes importants, et permet une décroissance rapide des champs de fuite. Lorsque quelques inducteurs sont en panne, le propulseur reste toujours opérationnel, mais les champs de fuite sont importants aux environs des modules hors service. Étant donné un matériau supraconducteur, il est possible de déterminer la forme des inducteurs dans le but de réduire à la fois les forces électromagnétiques et le surchamp supporté par le bobinage. Pour un propulseur annulaire constitué de 24 modules inducteurs, et un champ actif de 10 T au centre de la partie active du canal (r = 6 m) on obtient avec du Nb3Sn un champ maximun sur le conducteur de 15,5 T et la structure supporte une force de 10^8 N/m. De plus, la nécessité de placer des écrans magnétique ou supraconducteur en régime dégradé (mise

  4. Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

    Directory of Open Access Journals (Sweden)

    Hui-Lin Mao

    2017-11-01

    Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

  5. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  6. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS......: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group...... and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels. RESULTS: Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher su...

  7. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter

    2015-01-01

    The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative...... or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated...

  8. uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

    Science.gov (United States)

    Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

    2017-09-15

    In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.

  9. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

    Directory of Open Access Journals (Sweden)

    Line Hammer Dohn

    Full Text Available The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated by Immunohistochemistry as well as a significant association between uPAR positivity and increasing tumour stage and tumour grade. This demonstrates the robustness of our previous and current findings. In addition the association between uPAR positive myofibroblasts and poor survival was reproduced. The highest hazard ratios for survival were seen for uPAR positive myofibroblasts both at the invasive front and in tumour core. Evaluating uPAR expression by the actual score showed a significant association between uPAR positive myofibroblasts in tumour core and an increased risk of cancer specific mortality. Our investigations have generated new and valuable biological information about the cell types being involved in tumour invasion and progression through the plasminogen activation system.

  10. Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

    Science.gov (United States)

    Stanton, M. Mark; Nelson, Lisa K.; Benediktsson, Hallgrimur; Hollenberg, Morley D.; Buret, Andre G.; Ceri, Howard

    2013-01-01

    Background. Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. Methods. Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation. Results. Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice. Conclusions. PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor. PMID:24459330

  11. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  12. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

    Science.gov (United States)

    Pichaud, Franck

    2018-01-01

    The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  13. Study of a micro-sublimation apparatus with removal of the vapours by pumping; application to the analysis of fluorinated products (1963); Etude d'un appareillage de microsublimation avec entrainement des vapeurs par pompage et application a l'analyse des produits fluores (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Delvalle, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    Micro-sublimation analysis presents definite advantages both from the qualitative and quantitative points of view. An automatic micro-sublimation analysis apparatus has been developed for the analysis of fluorinated products (ClF{sub 3}, HF, UF{sub 6}, etc.) but this is only one particular application of a method which has a far wider field of possible applications. We give first the most favorable conditions for the operation of such an apparatus. These conditions are the use of a detector which is linear and independent of the nature of the gas, the flow of the sublimed vapours in the conditions of molecular flow, and finally a reproducible and linear re-heating of the separating trap. The apparatus thus built has the advantage of yielding any analysis without prior calibration. It also makes possible the easy identification of an unknown product by the determination of its vapour pressure curve and its molecular weight. The analysis of fluorinated products with this apparatus has shown that the experimental results agree well with what is expected. (author) [French] L'analyse par microsublimation presente un interet certain tant au point de vue qualitatif que quantitatif. Nous avons mis au point un appareillage automatique d'analyse par microsublimation pour l'analyse des produits fluores (CIF{sub 3}, HF, UF{sub 6}, etc.) mais il ne s'agit que de l'application a un cas particulier d'une methode ayant un champ d'applications bien plus vaste. Nous exposons tout d'abord les conditions les plus favorables au bon fonctionnement d'un tel appareil. Ces conditions sont l'emploi d'un detecteur lineaire et independant de la nature du gaz, l'ecoulement des vapeurs sublimees en regime moleculaire et enfin un rechauffage reproductible et lineaire du piege separateur. L'appareil ainsi realise presente l'avantage d'effectuer une analyse quelconque sans etalonnage prealable. Il permet en outre d'identifier aisement un corps inconnu par la determination de sa courbe de tension

  14. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  15. The pars intermedia: an anatomic basis for a coordinated vascular response to female genital arousal.

    Science.gov (United States)

    Shih, Cheryl; Cold, Christopher J; Yang, Claire C

    2013-06-01

    The pars intermedia is an area of the vulva that has been inconsistently described in the literature. We conducted anatomic studies to better describe the tissues and vascular structures of the pars intermedia and proposed a functional rationale of the pars intermedia in the female sexual response. Nine cadaveric vulvectomy specimens were used. Each was serially sectioned and stained with hematoxylin and eosin and Masson's trichrome. Histologic ultrastructural description of the pars intermedia. The pars intermedia contains veins traveling longitudinally in the angle of the clitoris, supported by collagen-rich stromal tissues. These veins drain the different vascular compartments of the vulva, including the clitoris, the bulbs, and labia minora; also, the interconnecting veins link the different vascular compartments. The pars intermedia is not composed of erectile tissue, distinguishing it from the erectile tissues of the corpora cavernosa of the clitoris as well as the corpus spongiosum of the clitoral (vestibular) bulbs. The venous communications of the pars intermedia, linking the erectile tissues with the other vascular compartments of the vulva, appear to provide the anatomic basis for a coordinated vascular response during female sexual arousal. © 2012 International Society for Sexual Medicine.

  16. PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

    Science.gov (United States)

    Zigler, Maya; Kamiya, Takafumi; Brantley, Emily C; Villares, Gabriel J; Bar-Eli, Menashe

    2011-11-01

    Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during melanoma progression. PAR-1 and its activating factors, which are expressed on tumor cells and the surrounding stroma, induce not only coagulation but also cell signaling, which promotes the metastatic phenotype. Several adhesion molecules, cytokines, growth factors, and proteases have recently been identified as downstream targets of PAR-1 and have been shown to modulate interactions between tumor cells and the microenvironment in the process of melanoma growth and metastasis. Inhibiting such interactions by targeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients. ©2011 AACR.

  17. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  18. Par Pond vegetation status summer 1995 - July survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-07-01

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond

  19. Tidal signatures of the thermospheric mass density and zonal wind at midlatitude: CHAMP and GRACE observations

    Directory of Open Access Journals (Sweden)

    C. Xiong

    2015-02-01

    Full Text Available By using the accelerometer measurements from CHAMP and GRACE satellites, the tidal signatures of the thermospheric mass density and zonal wind at midlatitudes have been analyzed in this study. The results show that the mass density and zonal wind at southern midlatitudes are dominated by a longitudinal wave-1 pattern. The most prominent tidal components in mass density and zonal wind are the diurnal tides D0 and DW2 and the semidiurnal tides SW1 and SW3. This is consistent with the tidal signatures in the F region electron density at midlatitudes as reported by Xiong and Lühr (2014. These same tidal components are observed both in the thermospheric and ionospheric quantities, supporting a mechanism that the non-migrating tides in the upper atmosphere are excited in situ by ion–neutral interactions at midlatitudes, consistent with the modeling results of Jones Jr. et al. (2013. We regard the thermospheric dynamics as the main driver for the electron density tidal structures. An example is the in-phase variation of D0 between electron density and mass density in both hemispheres. Further research including coupled atmospheric models is probably needed for explaining the similarities and differences between thermospheric and ionospheric tidal signals at midlatitudes.

  20. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    International Nuclear Information System (INIS)

    Kinney, Kathryn A.

    2009-01-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

  1. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  2. Comparaison du Pangola (Digitaria decumbens) et du Stargrass (Cynodon nlemfluensis) exploités par des ovins

    OpenAIRE

    Boval, Maryline

    1989-01-01

    A la Martinique l'utilisation comparée de Digitaria decumbens (Dd) et de Cynodon nlemfuensis (Cn) par des brebis allaitantes a été étudiée pendant une période d'observation de 6 mois. Le cheptel est à un taux élevé de 1 600 kg de poids vif par hectare et par an, obtenu par une fertilisation de 450 kg/ha/an en azote.

  3. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  4. Application of passive auto catalytic recombiner (PAR) for BWR plants in Japan

    International Nuclear Information System (INIS)

    Kobayashi, K.; Murano, K.; Yamanari, S.; Yamamoto, Y.

    2001-01-01

    The passive auto-catalytic recombiner (PAR), which can recombine flammable gases such as hydrogen and oxygen with each other to avoid an explosion in case of a loss-of-coolant accident (LOCA), installed in the primary containment vessel does not require a power supply or dynamic equipment, while the existing flammability gas control system (FCS) of most BWRs as an outer loop of the primary containment vessel needs them to make flammable gases circulate through blowers and heaters in the system. PAR offers a number of advantages over existing FCS, such as high reliability, low cost due to much smaller amount of materials needed, good maintainability, good operability in case of a LOCA, and smaller space for installation. An experimental study has been carried out for the purpose of solving the problems of applying PAR to Japanese BWR plants instead of existing FCS, in which we grasped the basic characteristics of PAR. (author)

  5. Relationship between the nuclear resonance of cobalt metal and its ferromagnetic properties; Relations entre la resonance nucleaire du cobalt metallique et ses proprietes ferromagnetiques

    Energy Technology Data Exchange (ETDEWEB)

    Aubrun, J.N. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-05-15

    resulte du couplage intense existant entre les noyaux et les electrons porteurs du magnetisme. Ces derniers excitent les noyaux et, dans les parois de Bloch, les soumettent a un champ radio-frequence bien plus intense que le champ RF applique. Les parametres de la resonance se determinent alors a partir du mouvement des parois, et dependent donc des constantes ferromagnetiques. La theorie permet de prevoir quantitativement certains effets particuliers, notamment par action d'un champ magnetique continu ou de la temperature. L'etude expeimentale a porte sur des poudres de cobalt et est en bon accord avec la theorie. Toutefois il faut tenir compte de l'effet de peau et reviser la theorie en consequence. Ceci permet d'expliquer certaines divergences observees, ainsi que l'influence de la taille des grains et celle du champ magnetique sur la forme de raie. Des renseignements originaux ont ete obtenus sur certaines proprietes purement ferromagnetiques du cobalt, en etudiant l'effet d'un champ magnetique et cette methode a pu etre appliquee a d'autres corps ferromagnetiques. En raison du caractere particulier de cette resonance nucleaire, qui se produit en l'absence de champ directeur et possede une importante largeur de raie, des spectrographes de type nouveau ont ete realises qui ont rendu possible des mesures precises de la forme de raie. La faible intensite des signaux obtenus dans certains cas a conduit a la mise au point d'une methode originale d'extraction dont la theorie et les applications pratiques sont donnees ici. L'ensemble de ces experiences fait apparaitre la resonance nucleaire comme un puissant moyen d'etude du ferromagnetique permettant de deceler des phenomenes microscopiques difficilement accessibles par les methodes classiques. (auteur)

  6. Relationship between the nuclear resonance of cobalt metal and its ferromagnetic properties; Relations entre la resonance nucleaire du cobalt metallique et ses proprietes ferromagnetiques

    Energy Technology Data Exchange (ETDEWEB)

    Aubrun, J N [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-05-15

    couplage intense existant entre les noyaux et les electrons porteurs du magnetisme. Ces derniers excitent les noyaux et, dans les parois de Bloch, les soumettent a un champ radio-frequence bien plus intense que le champ RF applique. Les parametres de la resonance se determinent alors a partir du mouvement des parois, et dependent donc des constantes ferromagnetiques. La theorie permet de prevoir quantitativement certains effets particuliers, notamment par action d'un champ magnetique continu ou de la temperature. L'etude expeimentale a porte sur des poudres de cobalt et est en bon accord avec la theorie. Toutefois il faut tenir compte de l'effet de peau et reviser la theorie en consequence. Ceci permet d'expliquer certaines divergences observees, ainsi que l'influence de la taille des grains et celle du champ magnetique sur la forme de raie. Des renseignements originaux ont ete obtenus sur certaines proprietes purement ferromagnetiques du cobalt, en etudiant l'effet d'un champ magnetique et cette methode a pu etre appliquee a d'autres corps ferromagnetiques. En raison du caractere particulier de cette resonance nucleaire, qui se produit en l'absence de champ directeur et possede une importante largeur de raie, des spectrographes de type nouveau ont ete realises qui ont rendu possible des mesures precises de la forme de raie. La faible intensite des signaux obtenus dans certains cas a conduit a la mise au point d'une methode originale d'extraction dont la theorie et les applications pratiques sont donnees ici. L'ensemble de ces experiences fait apparaitre la resonance nucleaire comme un puissant moyen d'etude du ferromagnetique permettant de deceler des phenomenes microscopiques difficilement accessibles par les methodes classiques. (auteur)

  7. Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

    Science.gov (United States)

    Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

    2013-01-01

    To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.

  8. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  9. [Roles of protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, in modulation of exocrine gland functions].

    Science.gov (United States)

    Nishikawa, Hiroyuki

    2006-07-01

    Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably binds to the extracellular loop 2 of the receptor itself. PAR-2 is widely distributed in the mammalian body and plays various roles in biological events in the cardiovascular, respiratory, alimentary, and central neurons systems. PAR-2-activating peptides administered systemically to mice and rats trigger prompt salivation in vivo. In an in vitro study, PAR-2 agonists including the endogenous PAR-2 activator trypsin induce secretion of amylase and mucin from isolated rat parotid glands and sublingual glands, respectively. PAR-2-activating peptides administered systemically also modulate pancreatic exocrine secretion in vivo as well as in vitro. In the gastric mucosa, PAR-2 stimulation enhances secretion of mucus and pepsinogen and suppresses acid secretion. Tear secretion can also be caused by PAR-2-related peptides in PAR-2-dependent and -independent manners. PAR-2 thus plays a general or key role in the regulation of exocrine secretion. This review focuses on the physiologic and/or pathophysiologic roles of PAR-2 in glandular exocrine secretion. The possibility of PAR-2 as a target for drug development is also discussed.

  10. Study of the properties of an electron linac beam by means of the electromagnetic fields associated with the beam; Etude des proprietes du faisceau d'electrons d'un accelerateur lineaire au moyen des champs electromagnetiques associes a ce faisceau

    Energy Technology Data Exchange (ETDEWEB)

    Bergere, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    For measuring the diverse characteristic parameters of a Linac electron beam, the one method causing the least perturbation to the electron beam itself, consists in the detection of signals induced in certain types of detectors by the electromagnets fields associated with the beam. Some particular detectors are then described, for measuring the following characteristic parameters of a Linac electron beam; a) electron beam peak current, a) longitudinal dimension and density of an elementary electron bunch, c) phase position of the electrons on the travelling sine wave of the accelerating field, d) transverse position of the beam. These particular electrodes are then used to provide experimental data In order to check the theoretical computations giving the longitudinal and transversal motions Of the electrons during their acceleration. (author) [French] Parmi les methodes de mesure des diverses caracteristiques du faisceau d'electrons d'un accelerateur lineaire, celles qui perturbent le moins le faisceau sont les methodes dans lesquelles l'energie du signal de mesure provient de la perturbation par l'electrode de mesure des champs electromagnetiques associes au faisceau. On decrit les electrodes de ce type qui ont ete mises au point pour mesurer les caracteristiques suivantes du faisceau d'electrons: a) courant crete, b) extension en phase d'un paquet elementaire d'electrons, c) phase d'accrochage des electrons, d) position transversale moyenne des electrons. On decrit ensuite comment les signaux provenant de ces diverses electrodes peuvent etre utilises pour verifier experimentalement les previsions theoriques des mouvements longitudinaux et transversaux des electrons en cours d'acceleration. (auteur)

  11. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1 in breast cancer invasion: signaling partners, hierarchy and physiological significance.

    Directory of Open Access Journals (Sweden)

    Irit Cohen

    Full Text Available BACKGROUND: While protease-activated-receptor 1 (PAR(1 plays a central role in tumor progression, little is known about the cell signaling involved. METHODOLOGY/PRINCIPAL FINDINGS: We show here the impact of PAR(1 cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis model in vivo, with biochemical analyses in vitro. Large and highly vascularized tumors were generated by cells over-expressing wt hPar1, Y397Z hPar1, with persistent signaling, or Y381A hPar1 mutant constructs. In contrast, cells over-expressing the truncated form of hPar1, which lacks the cytoplasmic tail, developed small or no tumors, similar to cells expressing empty vector or control untreated cells. Antibody array membranes revealed essential hPar1 partners including Etk/Bmx and Shc. PAR(1 activation induces Etk/Bmx and Shc binding to the receptor C-tail to form a complex. Y/A mutations in the PAR(1 C-tail did not prevent Shc-PAR(1 association, but enhanced the number of liver metastases compared with the already increased metastases obtained with wt hPar1. We found that Etk/Bmx first binds via the PH domain to a region of seven residues, located between C378-S384 in PAR(1 C-tail, enabling subsequent Shc association. Importantly, expression of the hPar1-7A mutant form (substituted A, residues 378-384, which is incapable of binding Etk/Bmx, resulted in inhibition of invasion through Matrigel-coated membranes. Similarly, knocking down Etk/Bmx inhibited PAR(1-induced MDA-MB-435 cell migration. In addition, intact spheroid morphogenesis of MCF10A cells is markedly disrupted by the ectopic expression of wt hPar1. In contrast, the forced expression of the hPar1-7A mutant results in normal ball-shaped spheroids. Thus, by preventing binding of Etk/Bmx to PAR(1 -C-tail, hPar1 oncogenic properties are abrogated. CONCLUSIONS/SIGNIFICANCE: This is the first demonstration that a cytoplasmic portion of the PAR(1 C-tail functions as a scaffold

  12. Study of the synthesized plasma resulting from forced neutralization of a mercury ions beam; Etude du plasma de synthese resultant de la neutralisation forcee d'un faisceau d'ions Hg{sup +}

    Energy Technology Data Exchange (ETDEWEB)

    Spiess, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    , en l'absence de champ electromagnetique externe. La presence d'un champ electrique longitudinal, cree par une grille polarisee et plongee dans le faisceau, modifie les conditions de stabilite du plasma de synthese. (auteur)

  13. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  14. L’Angélus dans la boîte à lettres*

    OpenAIRE

    Jr, William A. Christian; Mittermaier, Amira

    2015-01-01

    En France, la popularité des cartes postales inspirées de L’Angélus de Jean-François Millet coïncide avec les débats publics qui ont accompagné la promulgation de la loi Combes de 1905. À partir des centaines de cartes accessibles sur le site internet de vente aux enchères Delcampe, les auteurs étudient les messages portés par les cartes, recensent le sexe des correspondants (majoritairement des femmes), et comparent les nombreuses images qui rejouent le couple en prière dans un champ. Aux di...

  15. Inertial currents in the Indian Ocean derived from satellite tracked surface drifters

    Digital Repository Service at National Institute of Oceanography (India)

    Saji, P.K.; Shenoi, S.S.C.; Almeida, A.M.; Rao, L.V.G.

    tropical. Largue´s a`15me`tres de profondeur, ces flotteurs pre´sentent une vitesse de de´rive infe´rieure a` 0,1 % de celle du vent. Le spectre de rotation des composantes de la vitesse superficielle souligne l’importance des courants d’inertie. Ceux...-ci sont circulaires (coefficient de rotation \\0.5), tre`s intermittents et ils contribuent environ a` 46 % de l’e´nergie cine´tique totale du champ de courants superficiels. Les e´ve´nements de l’activite´ inertielle, qu’ils soient provoque´s par le...

  16. Poirier Nicolas, Un espace rural à la loupe. Paysage, peuplement et territoires en Berry de la préhistoire à nos jours

    Directory of Open Access Journals (Sweden)

    Frédérique Bertoncello

    2011-01-01

    Full Text Available Cet ouvrage est la publication de la thèse de Doctorat soutenue par Nicolas Poirier à l’Université de Tours en décembre 2007. L’originalité de l’étude tient à l’échelle d’analyse adoptée pour retracer la dynamique d’un espace rural aux confins du Berry et du Nivernais, qui associe micro-échelle spatiale (une cinquantaine de km² correspondant aux territoires des communes de Sancergues, Charentonnay et Saint-Martin-des-Champs, à l’est du département du Cher et longue durée chronologique (du se...

  17. Odométrie visuelle en milieu naturel pour les robots mobiles

    OpenAIRE

    Duperal, B.

    2013-01-01

    / Dans le cadre de ce stage, l'objectif est d'étudier les performances de la vision artificielle, pour permettre à un robot mobile de se localiser, en utilisant soit une caméra, soit un système de stéréovision, dans un environnement naturel (arbres, cultures, champs agricoles, bâtiments,...), suite à des pertes de signal GPS. La localisation de robots par vision artificielle nécessite de réaliser des opérations d'appariement de points invariants (détection d'amers, zones particulières sur ...

  18. Diasporas et TIC: la territorialité en question. L'exemple de la communauté des Albanais du Kosovo en Suisse

    OpenAIRE

    NOIRJEAN, Sophie; VODOZ, Luc

    2009-01-01

    Cette recherche s'inscrit dans le cadre des travaux du Working Group 2 «Humans as e-Actors» de l'Action COST 298 (programme européen de recherche dont le thème est « Participation in the Broadband Society »), et plus particulièrement dans la thématique portant sur les diasporas. L'usage des technologies de l'information et de la communication (TIC) par les diasporas constitue un champ d'investigation intéressant dans la mesure où les besoins et les pratiques de communication de ces communauté...

  19. Conflits et conflictualités

    Directory of Open Access Journals (Sweden)

    2010-12-01

    Full Text Available Conflits de proximitéLe premier panel du séminaire s’est articulé autour du conflit de proximité. Ouvert par une introduction consacrée aux liens entre voisinage et violence, il a apporté deux illustrations à travers deux études de cas : à l’échelle d’une institution culturelle franco-allemande d’abord, puis au sein d’une communauté sociale particulière.La communication de Ulrich Bielefeld, intitulée « Proximité et violence », envisage le voisinage comme champ d’émergence du conflit, au sens ...

  20. La communication de recrutement dans le milieu hospitalier

    OpenAIRE

    Medina, Pablo

    2011-01-01

    Le développement de la communication institutionnelle et du marketing au sein des institutions hospitalières est très influencé par les changements qui ont lieu dans le milieu sanitaire. La communication de recrutement est l’une des activités les plus stratégiques dans ce cadre, non seulement parce qu’elle répond à des objectifs organisationnels très précis, mais aussi parce qu’elle contribue au développement du champ de la communication institutionnelle dans les hôpitaux. Mais, pour y réussi...

  1. Ecrire et s'écrire en prison

    OpenAIRE

    Lionel Rebout

    2010-01-01

    Dans cette contribution, j’entendrai l’écriture de soi au sens de la subjectivité, c’est-à-dire un rapport à soi nécessairement recomposé et remis en cause dans le champ carcéral, cadre décontenançant par la force des choses et source d’une souffrance originale dans la vie d’un homme. Et j’entendrai l’écriture de soi dans ses rapports à l’écriture en tant que technique, pratique de l’intime pour approcher, saisir, questionner l’autre écriture, celle de soi. Ainsi j’interrogerai la prison lors...

  2. Production and study of high intensity discharges; Production et etude de decharges a forte intensite

    Energy Technology Data Exchange (ETDEWEB)

    Breton, C; Charbon, J; Hubert, P; Vendryes, G; Yvon, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1957-07-01

    High intensity discharges have been induced in a pyrex toroid filled with argon or deuterium at low pressure. An attempt was made to stabilise the ring of plasma by the joint action of a metal screen and a longitudinal magnetic field. Penetrating X-ray have been observed under certain conditions. (author) [French] Des decharges a forte intensite ont ete induites dans une tore en pyrex rempli d'argon ou de deuterium sous basse pression. On a cherche a stabiliser l'anneau de plasma par l'action conjuguee d'un champ magnetique longitudinal. Un rayon X penetrant a ete observe dans certaines conditions. (auteur)

  3. La couleur des menuiseries : méthodes et résultats pratiques The colour of door and window casings: practical methods and results

    Directory of Open Access Journals (Sweden)

    Michel Bourlier

    2008-04-01

    Full Text Available Les exigences les plus strictes doivent présider à toute décision de remise en état, aussi modeste soit-elle, de ce patrimoine mondial qui motive les échanges de ce jour. Domaine royal, demeure seigneuriale comme simple maison de ville ou des champs : seule la rigueur doit accompagner les exigences d’aujourd’hui pour répondre à celles de la culture de demain. La justification du choix de l’un de ces coloris déterminants pour la juste appréciation d’une architecture, l’inclination, guidée par ...

  4. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Franck Pichaud

    2018-03-01

    Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  5. La diversité vue par un journal communautaire maghrébin à Montréal

    Directory of Open Access Journals (Sweden)

    Rachad Antonius

    2009-01-01

    Full Text Available Cet article se situe dans le champ d’étude des médias “communautaires” ou ethniques. Il analyse la couverture, par le journal communautaire maghrébin Atlas.Mtl, de la question de la diversité au Québec. L’analyse montre qu’Atlas.Mtl s’inscrit dans une logique de négociation des rapports de force entre les citoyens d’origine maghrébine et le groupe majoritaire, dans le cadre d’un système hégémonique dont il ne conteste pas les fondements. Son approche est non conflictuelle, et le journal adopte un ton généralement conciliant qui ne rejette pas globalement les avantages d’un système libéral et laïque, contrastant ainsi avec d’autres journaux plus radicaux dans leurs revendications. On y trouve une ouverture à la diversité d’opinions. En dehors des périodes de tension sociale où le discours sur l’immigration et sur la diversité s’est durci, le contenu du journal revient à un ton moins revendicateur. Son apport se situe davantage au niveau de l’information qu’à celui de la revendication, avec une préoccupation claire pour la modification des situations d’inégalité. Il s’en dégage une orientation générale qui propose une identité arabo-musulmane laïque, modérée et libérale, spécifiquement maghrébine, assumant son appartenance à une société québécoise laïque, et faisant partie de la diaspora internationale maghrébine. Nous situerons cette orientation dans les débats entre le courant des études post-coloniales et les courants qui insistent sur les orientations économiques et intégrationnistes des médias ethniques minoritaires, et nous proposerons des interprétations du positionnement du journal qui font référence au grand débat entre islamisme et nationalisme laïque dans les pays arabes.

  6. Is the cooling of coils of pulsed accelerators profitable?; Le refroidissement des bobines des accelerateurs pulses est-il avantageux?

    Energy Technology Data Exchange (ETDEWEB)

    Neyret, G.; Parain, J.; Schnuriger, J. C.

    1960-05-15

    In this report, the authors recall how metal resistivity decreases at low temperatures, and give some indications about the power and price of cryogenic installations. They report the study of the cooling of coils in accelerators displaying an alternate gradient with a 15 GeV energy, with or without a magnetic circuit in iron. They establish that cooling does not result in a decrease in the cost price for an hour of operation. They also state that it is not even sure that this cooling would result in a dimension reduction while increasing the maximum achievable induction [French] On rappelle comment la resistivite des metaux diminue aux basses temperatures, et on donne des indications sur la puissance et le prix des installations cryogeniques. On etudie le refroidissement des bobines d'accelerateurs a gradient alterne d'une energie de 15 GeV, avec ou sans circuit magnetique en fer; on trouve que le refroidissement ne permet pas de diminuer le prix de revient de l'heure de fonctionnement; il n'est meme pas sur qu'il puisse permettre de reduire les dimensions en elevant l'induction maximum realisable. L'idee de refroidir les bobines sans fer jusqu'a la temperature de l'air liquide est ancienne: Jean Perrin des 1907, puis Charly Fabry en 1910 l'avaient deja proposee. Recemment, cette idee est revenue a l'actualite: en 1958, R.F. Post a suggere de l'appliquer a la production de champs intenses en vue du confinement des plasmas thermonucleaires; en 1959, N.C. Christofilos a publie un projet d'accelerateur refroidi a 80 deg. K. Nous voulons examiner l'interet de refroidir les bobines d'un accelerateur, d'une part pour augmenter l'induction maximum (dans le cas de machines sans fer) et d'autre part pour diminuer l'importance de l'alimentation electrique. Cet examen est precede de generalites sur le refroidissement des bobines, generalites qui s'appliquent d'ailleurs a tous les champs magnetiques. Les trois metaux etudies sont ceux retenus comme les meilleurs par Post: le

  7. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  8. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  9. Measures and modelling of PAR (photosynthetically-active radiation) for the Northeast of Brazil; Medidas e modelagem da radiacao PAR (photosynthetically-active radiation) para o nordeste do Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Tiba, Chigueru; Leal, Sergio da S.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear], e-mail: tiba@rce.neoline.com.br

    2004-07-01

    Photosynthetically active solar radiation, known by its acronym in the English language as PAR, is the principal driving force of innumerable biological and physical processes related to biomass production, such as, the evolution of vegetal covering, agricultural productivity, and countless environment aspects, among others. Unfortunately in Brazil and particularly in the Northeast of Brazil, the PAR radiation measures are not a routine part of meteorological station measures, and therefore are still rarer than solar irradiation measures. In this context, a station was installed in Recife, Pernambuco in 2003, to carry out simultaneous measures of daily solar irradiation and PAR irradiation, which permits the modelling and valuation of the relationship between these two parameters and thus makes the estimation of PAR radiation possible, where there used to be only information on solar irradiation. Three others stations are being installed, one on Fernando de Noronha-PE, another in Pesqueira-PE, and the other in Xingo-SE, which complete a group of 4 between Latitudes 8 deg and 10 deg South and Longitudes 34 deg to 38 deg West, each having differentiated Equatorial Climates: island maritime, continental maritime, sylvan (Agreste) and semi-arid. (author)

  10. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  11. RESOLUTION DU PROBLEME DE PREDICTION LINEAIRE PAR LA METHODE ULV. APPLICATION AU SIGNAL FID

    Directory of Open Access Journals (Sweden)

    M KHELIF

    2003-06-01

    Full Text Available Dans le cadre de la spectroscopie RMN, notre objectif est de déterminer le spectre d'absorption du signal de précession libre FID par la méthode de prédiction linéaire (PL. Ceci revient à résoudre le problème de prédiction linéaire en exploitant la méthode de corrélation par l'utilisation de la décomposition en valeurs singulières SVD pour l'inversion de la matrice de corrélation. Or, cette technique est la source d'un certain nombre de problèmes lorsque le signal est noyé dans du bruit. Aussi sera-t-elle coûteuse en temps lorsque les dimensions de la matrice de corrélation sont importantes. Afin de résoudre ce problème, nous exploitons les propriétés d'une nouvelle technique dérivée de la SVD, la décomposition ULV pour minimiser le coût du traitement et assurer une inversion correcte de la matrice de corrélation. Dans ce but, nous déterminons le spectre d'absorption par la technique ULV et nous le comparons avec le spectre déterminé par la SVD et  la FFT. Nous comparons par la suite la qualité des spectres obtenus par rapport au spectre d'absorption idéal  déterminé par FFT.

  12. Micro-striction 1 and 2 (1961); Microstriction 1 and 2 (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Alddieres, M; Aymar, R; Jourdan, P; Samain, A [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France)

    1961-07-01

    A certain quantity of gas is enclosed between two co-axial glass tubes (diameters 67 and 87 mm). In this annular space thus formed exists a permanent magnetic configuration, whose lines of force are perpendicular to the surface of the tubes (0-500 gauss). An electric field is then produced by induction such that its lines of force are circles whose axis coincides with that of the tubes (200 V/cm). The electric field lasts for 0.5 {mu}s. This field ionises the gas and causes an electric current to flow perpendicularly to the magnetic field. The corresponding Laplacian force accelerates the plasma along the axis of the tubes. In a first series of measurements, the discharge characteristics in the absence of a permanent field were studied. It is, in particular, convenient to group together all the irreversible phenomena which occur by assuming the existence of an electrical discharge resistance. The plasma movement in the permanent magnetic field induces in this latter a back-e.m.f. By taking into account the discharge resistance, the electric current and the forces tending to accelerate the plasma can be evaluated. The efficiency of the acceleration process has been measured. It passes through a maximum for a certain value of the permanent magnetic field. The experimental results have been compared with the simple model described above. (authors) [French] Une certaines quantite de gaz est enfermee entre deux tubes en verre de meme axe (diametres 6V et 87 mm). L'espace annulaire ainsi defini est le siege d'une configuration magnetique permanente, dont les lignes de force sont perpendiculaires a la surface des tubes (0-500 gauss). On fait apparaitre par induction un champ electrique dont les lignes de force sont des cercles dont l'axe coincide avec l'axe des tubes (200 V/cm). Ce champ electrique persiste pendant 0,5 {mu}s. Ce champ electrique ionise le gaz et fait circuler un courant electrique perpendiculaire au champ magnetique. La force de Laplace correspondante

  13. Compte rendu de Gouanvic (Jean-Marc, Pratique sociale de la traduction. Le roman réaliste américain dans le champ littéraire français (1920-1960

    Directory of Open Access Journals (Sweden)

    Séverine Olivier

    2008-04-01

    Full Text Available Pratique sociale de la traduction fait suite à l’ouvrage Sociologie de la traduction (1999, dans lequel Jean-Marc Gouanvic analysait l’introduction de la science-fiction américaine dans la France des années 1950 et l’émergence concomitante d’un champ autonome de la science-fiction française. Dans son nouvel opus, Gouanvic se penche sur le genre romanesque réaliste — genre qu’il considère comme dominant en Occident — et plus particulièrement sur la traduction de romans réalistes américains da...

  14. CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

    Energy Technology Data Exchange (ETDEWEB)

    Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

    2016-12-15

    Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions

  15. Displacements and intensities of the components of hydrogenic lines of the helium atom in the presence of exterior uniform electrical and magnetic fields; Deplacements et intensites des composantes des raies hydrogenoides de l'atome d'helium en presence de champs exterieurs electrique et magnetique uniformes

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, C; Herman, L; Nguyen, H [Laboratoire de Recherches Physiques, 75 - Paris (France); Drawin, H W [Commissariat a l' Energie Atomique, Association Euratom-CEA, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-07-01

    The Waller-Foster method for hydrogenic lines of neutral helium is extended in order to take into account an external magnetic field (vector K) having an arbitrary angle with an external constant electric field (vector F). The diagonal correction has been evaluated numerically taking into account recent experimental data. A Fortran IV program written for the CDC 3600 computer allows to calculate the displacements and the intensities for any hydrogenic transition. Special attention is given to the {l_brace}2-4{r_brace} transitions in neutral helium. (authors) [French] La methode de perturbation de Waller et Foster est generalisee afin de tenir compte d'un champ magnetique exterieur (vecteurK) faisant un angle quelconque avec un champ electrique exterieur (vecteurF). La correction diagonale des matrices de perturbation est evaluee numeriquement a l'aide des donnees atomiques les plus recentes. Un programme ecrit pour l'ordinateur CDC 3600 permet le calcul des deplacements et des intensites pour des transitions hydrogenoides quelconques. Les transitions [2-4]d'helium neutre ont ete etudiees plus particulierement. (auteurs)

  16. A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.

    Science.gov (United States)

    Dickinson, Daniel J; Schwager, Francoise; Pintard, Lionel; Gotta, Monica; Goldstein, Bob

    2017-08-21

    Regulated protein-protein interactions are critical for cell signaling, differentiation, and development. For the study of dynamic regulation of protein interactions in vivo, there is a need for techniques that can yield time-resolved information and probe multiple protein binding partners simultaneously, using small amounts of starting material. Here we describe a single-cell protein interaction assay. Single-cell lysates are generated at defined time points and analyzed using single-molecule pull-down, yielding information about dynamic protein complex regulation in vivo. We established the utility of this approach by studying PAR polarity proteins, which mediate polarization of many animal cell types. We uncovered striking regulation of PAR complex composition and stoichiometry during Caenorhabditis elegans zygote polarization, which takes place in less than 20 min. PAR complex dynamics are linked to the cell cycle by Polo-like kinase 1 and govern the movement of PAR proteins to establish polarity. Our results demonstrate an approach to study dynamic biochemical events in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  18. Numerical analysis of the influence of PAR unit elevation within a vessel on its performance

    International Nuclear Information System (INIS)

    Kotouč, Miroslav

    2011-01-01

    On the basis of successful validation of the MELCOR code on several experiments from the international OECD/NEA programme THAI, a numerical parametric study has been conducted at NRI Řež evaluating the influence of PAR's vertical position within a vessel on its performance. Simulations were carried out for an Areva PAR unit which was considered to be placed at 5 different elevations in the THAI test vessel, the sixth simulation comprised a model of blower, simulating thus forced convection. The initial conditions were those of the THAI HR-12 test, which was characterized by steam-saturated atmosphere at elevated pressure and temperature. The results show that the overall hydrogen mass recombined monotonically decreases with PAR elevation. This behavior is due to hot, light and hydrogen-lean plume, coming out from the PAR outlet, which, due to buoyancy forces, eventually fills the upper part of the vessel and prevents thus the PAR unit from efficient operation (if the latter is placed near the top). It was also demonstrated that the effect of forced convection is favorable since it breaks the gas stratification and increases thus hydrogen concentration at the PAR inlet. (author)

  19. Increased Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR Levels in Plasma of Suicide Attempters.

    Directory of Open Access Journals (Sweden)

    Filip Ventorp

    Full Text Available The soluble form of the urokinase receptor, suPAR, has been suggested as a novel biomarker of low-grade inflammation. Activation of the immune system has been proposed to contribute to the development of depression and suicidal behavior. In order to identify depressed and suicidal individuals who could benefit from an anti-inflammatory treatment, a reliable biomarker of low-grade inflammation is vital. This study evaluates plasma suPAR levels as a biomarker of low-grade inflammation in patients with major depressive disorder and in patients who recently attempted suicide. The plasma suPAR and an established biomarker, C reactive protein (CRP of suicide attempters (n = 54, depressed patients (n = 19 and healthy controls (n = 19 was analyzed with enzyme-linked immunosorbent assays. The biomarker attributes of sensitivity and sensibility were evaluated using ROC curve analysis. Both the depressed patients and suicide attempters had increased plasma suPAR. The levels of suPAR discriminated better between controls and suicide attempters than did CRP. In the future, plasma suPAR might be a superior prognosticator regarding outcome of treatment applying conventional antidepressants in conjunction with anti-inflammatory drugs.

  20. Theoretical and experimental study of a non-linear disintegration process for a langmuir wave; Etude theorique et experimental d'un processus non lineaire de desintegration d'une onde de langmuir

    Energy Technology Data Exchange (ETDEWEB)

    Perulli, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    Using the Vlasov equation we calculate and discuss non-linear coupling equations between three electronic plasma waves (Langmuir waves) which propagate in a cylindrical plasma column confined by a strong magnetic field. We study, in the experimental device EOS, along the magnetic field, the disintegration of a Langmuir wave excited in the plasma column by means of an antenna. Space structure measurements for various waves show that the resonance conditions (selection rules) are satisfied. The measured disintegration threshold is in agreement with the theoretical value within 30 per cent and shows that this non linear mechanism appears when the oscillating density to the mean density ratio is about 10{sup -3} to 10{sup -2}. The variation of the spatial growth rate as a function of the amplitude of the disintegrated wave shows that the resulting waves are correlated in groups of three along the magnetic field even though the disintegrating spectrum appears in a wide frequency band. (author) [French] A partir de l'equation de Vlasov nous calculons et discutons les equations de couplage non lineaire entre trois ondes plasma electroniques (ou ondes de Langmuir) qui se propagent dans une colonne de plasma cylindrique confinee par un champ magnetique de forte intensite. Nous etudions, dans le dispositif experimental EOS, le long du champ magnetique, la desintegration d'une onde de Langmuir excitee dans la colonne de plasma a l'aide d'une antenne. La mesure de la structure spatiale des differentes ondes montre que l'ensemble des conditions de resonance (ou regles de selection) sont satisfaites. Le seuil de desintegration mesure est en accord avec la valeur theorique a 30 pour cent pres et montre que ce mecanisme non lineaire apparait lorsque le rapport de la densite oscillante a la densite moyenne est de l'ordre de 10{sup -3} a 10{sup -2}. La variation du taux de croissance spatiale en fonction de l'amplitude de l'onde qui se desintegre montre que les ondes restent trois

  1. Theoretical and experimental study of a non-linear disintegration process for a langmuir wave; Etude theorique et experimental d'un processus non lineaire de desintegration d'une onde de langmuir

    Energy Technology Data Exchange (ETDEWEB)

    Perulli, M. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    Using the Vlasov equation we calculate and discuss non-linear coupling equations between three electronic plasma waves (Langmuir waves) which propagate in a cylindrical plasma column confined by a strong magnetic field. We study, in the experimental device EOS, along the magnetic field, the disintegration of a Langmuir wave excited in the plasma column by means of an antenna. Space structure measurements for various waves show that the resonance conditions (selection rules) are satisfied. The measured disintegration threshold is in agreement with the theoretical value within 30 per cent and shows that this non linear mechanism appears when the oscillating density to the mean density ratio is about 10{sup -3} to 10{sup -2}. The variation of the spatial growth rate as a function of the amplitude of the disintegrated wave shows that the resulting waves are correlated in groups of three along the magnetic field even though the disintegrating spectrum appears in a wide frequency band. (author) [French] A partir de l'equation de Vlasov nous calculons et discutons les equations de couplage non lineaire entre trois ondes plasma electroniques (ou ondes de Langmuir) qui se propagent dans une colonne de plasma cylindrique confinee par un champ magnetique de forte intensite. Nous etudions, dans le dispositif experimental EOS, le long du champ magnetique, la desintegration d'une onde de Langmuir excitee dans la colonne de plasma a l'aide d'une antenne. La mesure de la structure spatiale des differentes ondes montre que l'ensemble des conditions de resonance (ou regles de selection) sont satisfaites. Le seuil de desintegration mesure est en accord avec la valeur theorique a 30 pour cent pres et montre que ce mecanisme non lineaire apparait lorsque le rapport de la densite oscillante a la densite moyenne est de l'ordre de 10{sup -3} a 10{sup -2}. La variation du taux de croissance spatiale en fonction de l'amplitude de l'onde qui se

  2. Pars plana vitrectomy for disturbing primary vitreous floaters: clinical outcome and patient satisfaction

    NARCIS (Netherlands)

    Nie, K.F. de; Crama, N.; Tilanus, M.A.D.; Klevering, B.J.; Boon, C.J.F.

    2013-01-01

    BACKGROUND: Primary vitreous floaters can be highly bothersome in some patients. In the case of persistently bothersome floaters, pars plana vitrectomy may be the most effective treatment. The aim of this study is to evaluate the incidence of complications, and patient satisfaction, after pars plana

  3. Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

    Directory of Open Access Journals (Sweden)

    Kara R Barber

    2017-02-01

    Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.

  4. Localization of amylin-like immunoreactivity in melanocyte-stimulating hormone-containing cells of the pars intermedia but not those of the pars distalis in the axolotl (Ambystoma mexicanum) pituitary.

    Science.gov (United States)

    Suzuki, Hirohumi; Yamamoto, Toshiharu

    2016-04-01

    Immunohistochemical techniques were employed to investigate the distribution of amylin-like immunoreactivity in the axolotl (Ambystoma mexicanum) pituitary. Amylin-immunoreactive cells were observed in the pars intermedia, and these cells were found to be immunoreactive for α-melanocyte-stimulating hormone (αMSH) as well. In contrast, αMSH-immunoreactive cells in the pars distalis were immuno-negaitive for amylin. These light microscopic findings were confirmed by immunoelectron microscopy. Amylin-immunoreactive signals were located on the haloes of presumable secretory granules in association with αMSH-immunoreactive signals in the amylin-positive cells. However, in the pars distalis, the αMSH-positive cells did not contain amylin-immunoreactive secretory granules. Western blot analysis of axolotl pituitary extracts revealed the labeling of a protein band at approximately 10.5-kDa by the anti-rat amylin serum, which was not labeled by the anti-αMSH antibody. These findings indicate that amylin secreted from MSH-producing cells in the pars intermedia may modulate MSH secretion in an autocrine fashion and may participate in MSH functions such as fatty homeostasis together with MSH. Copyright © 2016 Elsevier GmbH. All rights reserved.

  5. evaluation de la fertilite femelle des arabusta par le niveau de ...

    African Journals Online (AJOL)

    Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...

  6. Layered superconductors in a parallel field: on the mixed state at equilibrium

    Science.gov (United States)

    Carton, J. P.

    1991-01-01

    The model describes a set of superconducting planes weakly coupled by Josephson tunnelling. When a magnetic field is applied parallel to the layers and the temperature is low enough so that the interplane coherence length is smaller than the corresponding spacing a, vortex cores fit in between two adjacent planes. In this case the mixed state is studied for high and low fields. The results are consistent with an isosceles triangle picture for the unit cell of the vortex lattice. H_{c1allel} is found to be frac{\\varphi0}{4πλ_Jλ}lnfrac{λ}{a} where λ and λ_J are the two penetration lengths. Le modèle décrit un ensemble de plans supraconducteurs faiblement couplés par effet Josephson. Quand un champ magnétique est appliqué parallèlement aux couches et que la températures est assez basse pour que la longueur de cohérence entre plans soit inférieure à leur distance a, les coeurs de vortex s'ajustent entre deux plans consécutifs. L'état mixte est étudié dans ce cas pour des champs forts et des champs faibles. Les résultats sont compatibles avec un triangle isocèle comme cellule de base du réseau de vortex. On trouve H_{c1allel}=frac{\\varphi0}{4πλ_Jλ}lnλ/a ou λ et λ_J sont les deux longueurs de pénétration.

  7. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  8. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

    2011-11-18

    The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  9. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    Dunn, Andrew J.; Campbell, Robert S.D.; Mayor, Peter E.; Rees, Dai

    2008-01-01

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  10. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Andrew J.; Campbell, Robert S.D. [Royal Liverpool and Broadgreen University Teaching Hospitals, Department of Medical Imaging, Liverpool (United Kingdom); Mayor, Peter E. [Leighton Hospital, Department of Medical Imaging, Crewe, Cheshire (United Kingdom); Rees, Dai [Robert Jones and Agnes-Hunt Orthopaedic Hospital, Department of Orthopaedic Surgery, Oswestry, Shropshire (United Kingdom)

    2008-05-15

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  11. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  12. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  13. Hep par-1: a novel immunohistochemical marker for differentiating hepatocellular carcinoma from metastatic carcinoma

    International Nuclear Information System (INIS)

    Hanif, R.

    2014-01-01

    To evaluate the diagnostic utility of Hep par-1 in differentiating hepatocellular carcinoma from metastatic carcinoma taking histopathology as a gold standard. Study Design: Comparative cross-sectional study. Place and Duration of Study: Pathology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from April 2007 to February 2008. Methodology: Hep par-1 immunohistochemical stain was performed on 60 cases of liver carcinoma, 30 cases each of metastatic and hepatocellular carcinoma. Information regarding patient age, gender, sign and symptoms, radiographic findings, histological grade of tumour, and expression of Hep par-1 on hepatocellular and metastatic carcinoma were recorded on proforma sheet. Sensitivity, specificity, positive and negative predictive values, and accuracy of Hep par-1 were calculated using the formulas. Results: Hep par-1 expression was noted in 25 out of 30 cases of hepatocellular carcinoma (83%). Out of 30 cases of metastatic carcinoma, only one case expressed staining in < 5% tumour cells and remaining 29 cases showed no reactivity. The age of the patients with hepatocellular carcinoma ranged from 40 to 76 years with a median age of 60.5 years and 40 - 75 years for metastatic carcinomas with a median age of 57.5 years. Conclusion: Hep par-1 is a reliable immunohistochemical marker for cases of hepatocellular carcinoma (HCC). It can be used along with other markers in morphologically difficult cases when differential diagnosis lies between poorly differentiated HCC and metastatic carcinoma of liver. (author)

  14. Paraplégie compliquant une plaie abdominale antérieure par arme blanche

    Science.gov (United States)

    Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2015-01-01

    Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808

  15. In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

    Science.gov (United States)

    Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto; Yanagihara, Itaru

    2015-04-01

    Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L-GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  16. Etude par imagerie radar des pollutions pétrolières

    Directory of Open Access Journals (Sweden)

    G. Rees

    2004-06-01

    Full Text Available En Russie, chaque année, les déversements de pétrole représentent un cinquième de la production totale. Les plus importants se produisent dans le domaine périglaciaire où le milieu naturel est d’une extrême fragilité. Les pipelines sont soumis à de rudes conditions notamment à la corrosion et aux processus cryogéniques. Le risque de rupture augmente en conséquence. La surveillance des déversements d’hydrocarbures, contrainte par l’immensité et la fréquente inaccessibilité du réseau de pipelines, peut être réalisée par le recours à la télédétection. L’objectif de ce travail est de fournir, à travers l’exemple de la catastrophe d’Usinsk (Rép. de Komi survenue en 1994, des outils d’analyse des images radar. Outre leur capacité à s’affranchir du couvert nuageux, les capteurs radar apportent des informations complémentaires à celles fournies par des capteurs optiques. L’exploitation thématique de ces images est rendue difficile par un certain nombre de facteurs perturbateurs tels que les caractéristiques propres du capteur, la direction de visée, la topographie et le phénomène de chatoiement (speckle. Le travail présenté montre le rôle prépondérant joué par ces corrections qui permettent de disposer de données quantitatives comparables d’une date à une autre. La méthode mise au point ici pour le suivi temporel de l’épanchement de pétrole d’Usinsk à partir de trois images radar, est discutée notamment dans ses limites et son aspect opérationnel possible.

  17. Field-aligned currents observed by CHAMP during the intense 2003 geomagnetic storm events

    Directory of Open Access Journals (Sweden)

    H. Wang

    2006-03-01

    Full Text Available This study concentrates on the characteristics of field-aligned currents (FACs in both hemispheres during the extreme storms in October and November 2003. High-resolution CHAMP magnetic data reflect the dynamics of FACs during these geomagnetic storms, which are different from normal periods. The peak intensity and most equatorward location of FACs in response to the storm phases are examined separately for both hemispheres, as well as for the dayside and nightside. The corresponding large-scale FAC peak densities are, on average, enhanced by about a factor of 5 compared to the quiet-time FACs' strengths. And the FAC densities on the dayside are, on average, 2.5 times larger in the Southern (summer than in the Northern (winter Hemisphere, while the observed intensities on the nightside are comparable between the two hemispheres. Solar wind dynamic pressure is correlated with the FACs strength on the dayside. However, the latitudinal variations of the FACs are compared with the variations in Dst and the interplanetary magnetic field component Bz, in order to determine how these parameters control the large-scale FACs' configuration in the polar region. We have determined that (1 the equatorward shift of FACs on the dayside is directly controlled by the southward IMF Bz and there is a saturation of the latitudinal displacement for large value of negative Bz. In the winter hemisphere this saturation occurs at higher latitudes than in the summer hemisphere. (2 The equatorward expansion of the nightside FACs is delayed with respect to the solar wind input. The poleward recovery of FACs on the nightside is slower than on the dayside. The latitudinal variations on the nightside are better described by the variations of the Dst index. (3 The latitudinal width of the FAC region on the nightside spreads over a wide range of about 25° in latitude.

  18. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

    DEFF Research Database (Denmark)

    Langkilde, Anne A; Hansen, Tine Willum; Ladelund, Steen

    2011-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... with respiratory, gastrointestinal and other cancer types, respectively.CONCLUSIONS: Elevated suPAR levels were associated with increased risk of incident respiratory cancer and other types of cancer, but not gastrointestinal cancers, independently of established risk factors, CRP and leukocyte numbers. Impact.......RESULTS: suPAR levels ranged from 0.6-22 ng/ml, and median suPAR level was 4.01 ng/ml. 1 ng/ml increase in baseline suPAR was associated with adjusted hazard ratios (HR) of 1.61 (95% CI: 1.23-2.11, P

  19. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    Science.gov (United States)

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  20. Spondylolysis outcomes in adolescents after direct screw repair of the pars interarticularis.

    Science.gov (United States)

    Snyder, Laura A; Shufflebarger, Harry; O'Brien, Michael F; Thind, Harjot; Theodore, Nicholas; Kakarla, Udaya K

    2014-09-01

    Isthmic spondylolysis can significantly decrease functional abilities, especially in adolescent athletes. Although treatment can range from observation to surgery, direct screw placement through the fractured pars, or Buck's procedure, may be a more minimally invasive procedure than the more common pedicle screw-hook construct. Review of surgical databases identified 16 consecutive patients treated with Buck's procedure from 2004 to 2010. Twelve patients were treated at Miami Children's Hospital and 4 at Barrow Neurological Institute. Demographics and clinical and radiographic outcomes were recorded and analyzed retrospectively. The 16 patients had a median age of 16 years, and 14 were 20 years or younger at the time of treatment. Symptoms included axial back pain in 100% of patients with concomitant radiculopathy in 38%. Pars defects were bilateral in 81% and unilateral in 19% for a total of 29 pars defects treated using Buck's procedure. Autograft or allograft augmented with recombinant human bone morphogenetic protein as well as postoperative bracing was used in all cases. Postoperatively, symptoms resolved completely or partially in 15 patients (94%). Of 29 pars defects, healing was observed in 26 (89.6%) prior to 1 revision surgery, and an overall fusion rate of 97% was observed at last radiological follow-up. There were no implant failures. All 8 athletes in this group had returned to play at last follow-up. Direct screw repair of the pars interarticularis defect as described in this series may provide a more minimally invasive treatment of adolescent patients with satisfactory clinical and radiological outcomes, including return to play of adolescent athletes.

  1. Compression robuste du signal par la transformée avec les B ...

    African Journals Online (AJOL)

    Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...

  2. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

    Directory of Open Access Journals (Sweden)

    Mariana Rodrigues Faleiro

    2013-06-01

    Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

  4. In vitro and in vivo inhibition of proangiogenic retinal phenotype by an antisense oligonucleotide downregulating uPAR expression.

    Science.gov (United States)

    Lulli, Matteo; Cammalleri, Maurizio; Granucci, Irene; Witort, Ewa; Bono, Silvia; Di Gesualdo, Federico; Lupia, Antonella; Loffredo, Rosa; Casini, Giovanni; Dal Monte, Massimo; Capaccioli, Sergio

    2017-08-26

    Neoangiogenesis is the main pathogenic event involved in a variety of retinal diseases. It has been recently demonstrated that inhibiting the urokinase-type plasminogen activator receptor (uPAR) results in reduced angiogenesis in a mouse model of oxygen-induced retinopathy (OIR), establishing uPAR as a therapeutic target in proliferative retinopathies. Here, we evaluated in cultured human retinal endothelial cells (HRECs) and in OIR mice the potential of a specific antisense oligodeoxyribonucleotide (ASO) in blocking the synthesis of uPAR and in providing antiangiogenic effects. uPAR expression in HRECs was inhibited by lipofection with the phosphorotioated 5'-CGGCGGGTGACCCATGTG-3' ASO-uPAR, complementary to the initial translation site of uPAR mRNA. Inhibition of uPAR expression via ASO-uPAR was evaluated in HRECs by analyzing VEGF-induced tube formation and migration. In addition, the well-established and reproducible murine OIR model was used to induce retinal neovascularization in vivo. OIR mice were injected intraperitoneally with ASO-uPAR and retinopathy was evaluated considering the extent of the avascular area in the central retina and neovascular tuft formation. The ASO-uPAR specifically decreased uPAR mRNA and protein levels in HRECs and mitigated VEGF-induced tube formation and cell migration. Noteworthy, in OIR mice ASO-uPAR administration reduced both the avascular area and the formation of neovascular tufts. In conclusion, although the extrapolation of these experimental findings to the clinic is not straightforward, ASO-uPAR may be considered a potential therapeutic tool for treatment of proliferative retinal diseases. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Silva, Jose Alberto Alves da

    2009-01-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  6. Avis 6 sur la formation à et par la recherche

    OpenAIRE

    Centre de Coopération Internationale en Recherche Agronomique pour le Développement

    2015-01-01

    La formation à et par la recherche s’appuie sur la démarche scientifique, les savoirs, les connaissances à transmettre, tout autant que l’acquisition de compétences en gestion de projet, de capacités au travail en équipe, d’une ouverture d’esprit qui favorisera la créativité. Elle doit permettre de prendre conscience de la responsabilité endossée par la communauté scientifique vis-à-vis de la société et de l’environnement, mais aussi préparer l’avenir professionnel de celle ou de celui qu...

  7. Désadification biologique des vins par les levures de fleur

    Directory of Open Access Journals (Sweden)

    C. LLAGUNO

    1971-03-01

    Le processus de désacidification bactérienne du vin par la fermentation malolactique est bien connu. Le vin acquiert ainsi une plus grande souplesse au goût et une stabilité biologique indispensable à sa conservation en bouteilles. Cependant, les levures Schizosaccharomyces pombe peuvent aussi fermenter l'acide malique (RIBÉREAU-GAYON et PEYNAUD, 1962. TARANTOLA et GANDINI, 1967 ont décrit des essais semi-industriels de désacidification biologique d'un moût blanc piémontais ; provoquée aussi bien par l'ensemencement de bactéries malolactiques  que de Schizosaccharomyces pombe.

  8. Recherche sur le paranormal et croyances irrationnelles: quel est le lien?

    Directory of Open Access Journals (Sweden)

    Marie-Catherine Mousseau

    2005-06-01

    Full Text Available A la fin du 19ième siècle, les phénomènes paranormaux étaient couramment étudiés et débattus par les scientifiques les plus renommés (l'astronome Camille Flammarion, les physiciens William Crook et Oliver Lodge, les prix Nobel Charles Richet, Pierre et Marie Curie, .... Les débats étaient intenses et de haut niveau. Leurs travaux étaient généralement publiés dans des journaux prestigieux. Ce champ d'étude était appelé 'métapsychique'. Aujourd'hui, les questions qu'ils avaient soulevées sont complètement ignorées par la communauté scientifique. Ses représentants prétendent que le débat est clos et le considèrent démodé et ridicule. C'est devenu une sorte de 'tabou', 'un des plus puissants interdits des temps modernes'.

  9. "Parīzes šiks" mūsdienu restorānu interjera dizainā

    OpenAIRE

    Kalnarāja, Agnese

    2015-01-01

    Diplomdarbā “Parīzes šiks mūsdienu restorānu interjera dizainā” sastāv no piecām nodaļām. Pirmajā nodaļā tiek aprakstīta Parīzes arhitektūras un interjera dizaina vēsture, tā ietekme uz “Parīzes šika” veidošanos, kā arī pētīta restorānu vēsture. Otrajā nodaļā tiek pētīti elementi, kas raksturo “Parīzes šika” interjeru. Trešajā nodaļā tiek analizēti un aprakstīti psiholoģiskie faktori, kas ietekmē restorānu dizainu – apgaismojums, krāsu lietojums un atmosfēras nozīme interjerā. Empīriskajā...

  10. Funding Research Through the Online Partnership to Accelerate Research (OnPAR

    Directory of Open Access Journals (Sweden)

    Martin A. Dueñas, MPA

    2016-10-01

    Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.

  11. Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

    International Nuclear Information System (INIS)

    Blanc-Brude, Olivier P.; Archer, Fabienne; Leoni, Patricia; Derian, Claudia; Bolsover, Steven; Laurent, Geoffrey J.; Chambers, Rachel C.

    2005-01-01

    Fibroblast proliferation and procollagen production are central features of tissue repair and fibrosis. In addition to its role in blood clotting, the coagulation cascade proteinase thrombin can contribute to tissue repair by stimulating fibroblasts via proteolytic activation of proteinase-activated receptor-1 (PAR 1 ). During hemostasis, the coagulation cascade proteinase factor X is converted into factor Xa. We have previously shown that factor Xa upregulates fibroblast proliferation via production of autocrine PDGF. In this study, we further examined the effects of factor Xa on fibroblast function and aimed to identify its signaling receptor. We showed that factor Xa stimulates procollagen promoter activity and protein production by human and mouse fibroblasts. This effect was independent of PDGF and thrombin production, but dependent on factor Xa proteolytic activity. We also showed that PAR 1 -deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR 1 -specific agonists and inhibitors were used to demonstrate that PAR 1 mediates factor Xa signaling in human fibroblasts. This is the first report that factor Xa stimulates extracellular matrix production. In contrast with endothelial cells and vascular smooth muscle cells, fibroblasts appear to be the only cell type in which the effects of factor Xa are mediated mainly via PAR 1 and not PAR 2 . These findings are critical for our understanding of tissue repair and fibrotic mechanisms, and for the design of novel approaches to inhibit the profibrotic effects of the coagulation cascade without compromising blood hemostasis

  12. Anti-Fatigue and Antioxidant Activity of the Polysaccharides Isolated from Millettiae speciosae Champ. Leguminosae

    Directory of Open Access Journals (Sweden)

    Xiao-Ning Zhao

    2015-10-01

    Full Text Available Millettiae speciosae Champ. Leguminosae (MSC, is a well-known Chinese herb traditionally used as food material and medicine for enhancing physical strength. Our preliminary study found that the aqueous extract of this herb (MSE had an anti-fatigue effect. In this paper, we further separated MSE into total polysaccharides (MSP and supernatant (MSS by alcohol precipitation, and explored which fraction was active for its anti-fatigue effect. Mice were orally administered with MSP or MSS at the doses of 200, 400, and 800 mg/kg for 20 days and the anti-fatigue effect was assessed by exhaustive swimming exercise (ESE. The biochemical parameters related to fatigue after ESE and the in vitro antioxidant activity of active fraction were determined. Our results showed that MSP, instead of MSS, significantly extended the swimming time to exhaustion (p < 0.05, indicating that MSP is responsible for the anti-fatigue effect of MSE. In addition, MSP treatment increased the levels of glucose (Glu and muscle glycogen, whereas it decreased the accumulations of blood urea nitrogen (BUN and lactic acid (Lac. Moreover, ESE increased the levels of creatine phosphokinase (CK, lactic dehydrogenase (LDH, and malondialdehyde (MDA but reduced superoxide dismutase (SOD and glutathione (GSH in plasma. In contrast, MSP inhibited all the above changes relating to fatigue. Furthermore, an in vitro antioxidant test revealed that MSP dose-dependently scavenged ·OH and DPPH free radicals. Taken together, these findings strongly suggested that MSP was able to alleviate physical fatigue by increasing energy resources and decreasing accumulation of detrimental metabolites. The antioxidant activity may crucially contribute to the observed anti-fatigue effect of MSP.

  13. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  14. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  15. The specific features of gold ore provinces of the south of Siberia in a magnetic field at ground height and heights of flight of satellite Champ.

    Science.gov (United States)

    Litvinova, Tamara; Petrova, Alevtina

    2010-05-01

    The specific features of gold ore provinces of the south of Siberia in a magnetic field at ground height and heights of flight of satellite Champ. T.Litvinova -All-Russian Geological Research Institute (VSEGEI) A. Petrova - St. Petersburg, SPbF IZMIRAN, Russian Academy of Sciences, St. Petersburg For allocation of specific features known gold ore objects (Olimpiadninskoje, Suchoi Log, etc.) is executed the morphological analysis of the magnetic field received on materials of aeromagnetic data and satellite measurements at heights of 100 and 400 km. On the ground data on a map of magnetic anomalies of Russia of scale 1:2 500000 of 50 km on the extended structures crossing known gold ore deposits and promising ore units have been constructed geomagnetic and densitys sections up to depth. On geomagnetic and densitys sections to known large gold ore to deposits are dated deep synvertical the permeable zones described by a synlenticular -layered structure. Extended horizons of not magnetic formations are located on depths about 10, 12, 15-18, 30 and 40 km. On deep densitys sections reference sites ¬ the Suchoi Log, Olimpiadninskoje and Vodorazdelnoje ¬ is characterized by zones of inversion of density. Areas of the loosened breeds are dated to synvertical to deep zones of hydrothermal and fluid study of breeds inside which the loosened lenses in intervals of depths from 2 up to 5 km are formed, 8-13 km, 18-20 and 25-30 km of 35-40 km within the limits of the bottom bark. The analysis of a magnetic field has shown, that gold mineralization in researched region is dated for zones of long-living regional explosive infringements, to permeable terrigenous to thicknesses of depressions, to adjournment depression structures in units of crossing of tectonofluid zones of diagonal orientation. Terrigenous adjournment depression structures are shown on a geomagnetic section as the powerful deflections filled with low-magnetic thicknesses. These deflections are dated to

  16. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.

    Science.gov (United States)

    Tripathi, Trivendra; Abdi, Mahshid; Alizadeh, Hassan

    2014-05-29

    Acanthamoeba plasminogen activator (aPA) is a serine protease elaborated by Acanthamoeba trophozoites that facilitates the invasion of trophozoites to the host and contributes to the pathogenesis of Acanthamoeba keratitis (AK). The aim of this study was to explore if aPA stimulates proinflammatory cytokine in human corneal epithelial (HCE) cells via the protease-activated receptors (PARs) pathway. Acanthamoeba castellanii trophozoites were grown in peptone-yeast extract glucose for 7 days, and the supernatants were collected and centrifuged. The aPA was purified using the fast protein liquid chromatography system, and aPA activity was determined by zymography assays. Human corneal epithelial cells were incubated with or without aPA (100 μg/mL), PAR1 agonists (thrombin, 10 μM; TRAP-6, 10 μM), and PAR2 agonists (SLIGRL-NH2, 100 μM; AC 55541, 10 μM) for 24 and 48 hours. Inhibition of PAR1 and PAR2 involved preincubating the HCE cells for 1 hour with the antagonist of PAR1 (SCH 79797, 60 μM) and PAR2 (FSLLRY-NH2, 100 μM) with or without aPA. Human corneal epithelial cells also were preincubated with PAR1 and PAR2 antagonists and then incubated with or without PAR1 agonists (thrombin and TRAP-6) and PAR2 agonists (SLIGRL-NH2 and AC 55541). Expression of PAR1 and PAR2 was examined by quantitative RT-PCR (qRT-PCR), flow cytometry, and immunocytochemistry. Interleukin-8 expression was quantified by qRT-PCR and ELISA. Human corneal epithelial cells constitutively expressed PAR1 and PAR2 mRNA. Acanthamoeba plasminogen activator and PAR2 agonists significantly upregulated PAR2 mRNA expression (1- and 2-fold, respectively) (P aPA, and PAR2 agonists induced PAR2 mRNA expression in HCE cells (P aPA, significantly upregulated PAR1 mRNA expression, which was significantly inhibited by PAR1 antagonist in HCE cells. Acanthamoeba plasminogen activator and PAR2 agonists stimulated IL-8 mRNA expression and protein production, which is significantly diminished by PAR2 antagonist

  17. Caractérisation de composites supraconducteurs aléatoires - phases au bismuth/argent : contribution à l'étude des jonctions faibles dans ces matériaux

    OpenAIRE

    Antunes , Laurent

    1998-01-01

    Les oxydes supraconducteurs à température critique élevée, à base de bismuth et comportant 2 ou 3 plans cuivre, sont synthétisés suivant diverses méthodes. Nous réalisons ensuite l'élaboration par frittage de matériaux composites aléatoires, constitués d'une dispersion de grains supraconducteurs de phase au bismuth 2212 dans une matrice d'argent. Nous étudions la résistivité électrique et l' aimantation en effet d'écran des matériaux en fonction de la température, du champ magnétique et de la...

  18. Le bovarysme, histoire et interprétation d’une pathologie littéraire à l’âge moderne

    Directory of Open Access Journals (Sweden)

    Delphine Jayot

    2009-02-01

    Full Text Available Originellement hybride, la notion de bovarysme, inventée à la fin du XIXe siècle par Jules de Gaultier, a été conçue à partir d’un personnage littéraire pour décrire un phénomène de psychologie normale ou pathologique. Creuset d’interrogations pour deux champs de savoir distincts, la littérature et la psychopathologie, elle va connaître un double destin en devenant, au XXe siècle, une notion clé de la critique littéraire comme de la psychiatrie. Au croisement de diverses disciplines, cette no...

  19. Production and study of high intensity discharges; Production et etude de decharges a forte intensite

    Energy Technology Data Exchange (ETDEWEB)

    Breton, C.; Charbon, J.; Hubert, P.; Vendryes, G.; Yvon, P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1957-07-01

    High intensity discharges have been induced in a pyrex toroid filled with argon or deuterium at low pressure. An attempt was made to stabilise the ring of plasma by the joint action of a metal screen and a longitudinal magnetic field. Penetrating X-ray have been observed under certain conditions. (author) [French] Des decharges a forte intensite ont ete induites dans une tore en pyrex rempli d'argon ou de deuterium sous basse pression. On a cherche a stabiliser l'anneau de plasma par l'action conjuguee d'un champ magnetique longitudinal. Un rayon X penetrant a ete observe dans certaines conditions. (auteur)

  20. Grafmeyer Yves, Authier Jean-Yves, Sociologie urbaine

    Directory of Open Access Journals (Sweden)

    Anaïs Van Sull

    2011-02-01

    Full Text Available Yves Grafmeyer et Jean-Yves Authier ont consacré la plupart de leurs travaux de recherche aux questions de l’espace urbain et de la socialisation qui y prend place. L’ouvrage qu’ils proposent, enrichi et actualisé par rapport à la première édition, aborde les différents objets, méthodes et problématiques qui peuvent être insérés dans le champ de la sociologie urbaine. S’ils reconnaissent une large part d’arbitraire dans les concepts et courants retenus, on ne peut que se réjouir des nouvelles...

  1. Lixiviation du potassium sous culture de pomme de terre irriguée en sol sableux : impact des engrais azotés

    OpenAIRE

    Chaouechi, Ameni

    2014-01-01

    Au Québec, la pomme de terre est cultivée sur des sols sableux favorisant les pertes par lixiviation de l’azote et du potassium. Selon le principe de réactions d’échanges cationiques, on a supposé que les doses et les sources d'azote puissent avoir un impact sur la lixiviation du potassium. Ainsi, une expérience a été menée, pendant trois années, dans un champ de pomme. Le dispositif expérimental est un bloc complet aléatoire de quatre répétitions constitué de 10 traitements qui sont un facto...

  2. Cécile ESTIVAL, Corps, imagerie médicale et relation soignant-soigné. Étude anthropologique au centre de cancérologie

    OpenAIRE

    Werner, Jean-François

    2011-01-01

    Cet ouvrage est directement issu d’une recherche doctorale, menée sous la direction de Sylvie Fainzang qui en a rédigé la préface. Comme l’indique le titre, il aborde l’imagerie médicale de manière oblique, en tant que médiation dans le rapport au corps (du patient à son propre corps, des soignants avec le corps du patient) et dans la relation soignant-soigné, soit deux champs de recherche amplement labourés par les anthropologues de la santé. Ce qui n’est pas le cas de l’imagerie médicale qu...

  3. Les assemblées représentatives (XVIe-XVIIIe siècle

    Directory of Open Access Journals (Sweden)

    Stéphane Durand

    2011-12-01

    Full Text Available Il y a bientôt vingt ans, en 1994, se tenait à Montpellier un colloque sur Les assemblées d’États dans la France méridionale à l’époque moderne, dont les actes furent publiés l’année suivante par Anne Blanchard, Henri Michel et Elie Pélaquier, avec une préface de Jean Bérenger. Le Centre d’Histoire Moderne de l’Université de Montpellier III d’alors s’engageait dans un champ de recherche en cours de renouvellement. En effet, quelques années auparavant, et longtemps après les travaux d’Armand R...

  4. Les enseignantes et enseignants sont-ils égaux face aux contraintes organisationnelles au sein des établissements du second degré ?

    OpenAIRE

    Cau-Bareille, Dominique

    2016-01-01

    Cet article présente une partie des résultats d’une recherche-action menée en France dans le champ de l’enseignement du second degré à la demande de deux syndicats. Celle-ci visait à comprendre les rapports de genre au sein des établissements et à éclairer les problèmes de harcèlement au travail évoqués plutôt par des femmes. Nous aborderons ici cette problématique sous l’angle des formes d’engagements dans l’activité professionnelle, en croisant le modèle ergonomique de l’activité de travail...

  5. La Maison du Roi sous Louis XIV, une troupe d’élite. Étude tactique

    OpenAIRE

    Chauviré, Frédéric

    2009-01-01

    La Maison du roi constitue le corps le plus prestigieux de l’armée royale. Mais c’est aussi une troupe d’élite, redoutée sur tous les champs de bataille. Sa supériorité tactique trouve son origine dans la singularité de sa doctrine de combat. Beaucoup plus manœuvrière que les régiments ordinaires, elle s’en distingue également par sa conduite de la charge : choix de l’arme blanche, adoption d’une allure élevée et recherche du choc. Les qualités de cette troupe expliquent que Louis XIV ait vou...

  6. Analyse de L'université et les TIC – Chronique d'une innovation annoncée

    Directory of Open Access Journals (Sweden)

    Jean Uebersfeld

    2013-04-01

    Full Text Available Date de réception et d'acceptation : octobre 2010. 1. Champ couvert par l'ouvrage L'ouvrage, comme l'indique son sous-titre, se présente comme une chronique de l'introduction des TIC (technologies de l'information et de la communication dans l'enseignement universitaire. On remarquera d'emblée que, même si le titre est très général, il faut entendre qu'il s'agit d'analyser des expériences s'organisant dans le cadre précis du Ruca (réseau universitaire des centres d'autoformation et des proj...

  7. Transverse Injection Experiment; Injection Transversale; Poslednie dostizheniya v oblasti inzhektirovaniya plazmy poperek magnitnogo polya; Inyeccion Transversal

    Energy Technology Data Exchange (ETDEWEB)

    Hammel, J. E.; Baker, D. A. [Los Alamos Scientific Laboratory, Los Alamos, NM (United States)

    1966-04-15

    magnetique a fait l'objet de diverses etudes. Au cours des premieres experiences d'injection d'un plasma rapide (50-70 cm/{mu}s) et dense (10{sup 14} ion/cm{sup 3}) transversalement a un champ magnetique, les auteurs ont observe un champ electrique d'autopolarisation et le plasma traversait le champ magnetique avec une derive du type E x B. Le champ magnetique n'etait que faiblement perturbe par le faisceau (| {Delta}B/B | <0.1), tandis que la vitesse de la derive, a travers des champs magnetiques pouvant atteindre 5 kG, etait approximativement egale a celle du plasma injecte. Le plasma derivant dans des regions a champ magnetique eleve, son epaisseur dans la direction de V x B diminue. Simultanement, des mesures de la densite des electrons par des methodes interferometriques avec le laser He-Ne montrent que le champ transversal pouvant atteindre 7 kG ne provoque pas d'etalement notable du plasma dans la direction de B. Il est interessant d'observer le comportement du plasma lorsqu'il traverse une region oh les lignes de champ magnetique changent de sens de part et d'autre d'une ligne d'intensite nulle. Lorsque le plasma traverse la separatrice entre les deux directions, il faut que le champ electrique change de sens pour que la derive du plasma puisse se prolonger. Le plasma s'arrete au voisinage de la separatrice et on mesure des courants importants le long des lignes de champ magnetique reliant la partie frontale du plasma aux parties suivantes. Des isolateurs, placesde maniere a interrompre le courant, permettent au plasma de passer dans la region de champ inverse. En utilisant l'inductance liee au courant de depolarisation lorsque les lignes de champ magnetique sont fixees a une certaine distance de la lisiere du plasma, il a ete possible de Separer les composantes lente et rapide du plasma. Les auteurs ont observe, par des methodes interferometriques, la coupure de la composante lente du plasma, a l'aide d'un laser He-Ne. Des mesures du champ electrique en plusieurs

  8. Parijs is een meervoud. Adriaan van Dis en de heruitvinding van de Hollander in Parijs

    NARCIS (Netherlands)

    Koffeman, M.N.; Koffeman, Maaike; Montoya, Alicia C.; Smeets, Marc

    2017-01-01

    Parijs, tot halverwege de 20ste eeuw het onbetwiste centrum van de Europese cultuur, heeft van oudsher een grote aantrekkingskracht uitgeoefend op Nederlandse kunstenaars en schrijvers. Velen van hen verbleven er kortere of langere tijd, op zoek naar internationale erkenning. De vrijere seksuele moraal

  9. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  10. Storm time dynamics of auroral electrojets: CHAMP observation and the Space Weather Modeling Framework comparison

    Directory of Open Access Journals (Sweden)

    H. Wang

    2008-03-01

    Full Text Available We investigate variations of the location and intensity of auroral currents during two magnetic storm periods based on magnetic field measurements from CHAMP separately for both hemispheres, as well as for the dayside and nightside. The corresponding auroral electrojet current densities are on average enhanced by about a factor of 7 compared to the quiet time current strengths. The nightside westward current densities are on average 1.8 (2.2 times larger than the dayside eastward current densities in the Northern (Southern Hemisphere. Both eastward and westward currents are present during the storm periods with the most intense electrojets appearing during the main phase of the storm, before the ring current maximizes in strength. The eastward and westward electrojet centers can expand to 55° MLat during intense storms, as is observed on 31 March 2001 with Dst=−387 nT. The equatorward shift of auroral currents on the dayside is closely controlled by the southward IMF, while the latitudinal variations on the nightside are better described by the variations of the Dst index. However, the equatorward and poleward motion of the nightside auroral currents occur earlier than the Dst variations. The Space Weather Modeling Framework (SWMF can capture the general dynamics of the storm time current variations. Both the model and the actual data show that the currents tend to saturate when the merging electric field is larger than 10 mV/m. However, the exact prediction of the temporal development of the currents is still not satisfactory.

  11. suPAR associates to glucose metabolic aberration during glucose stimulation in HIV-infected patients on HAART

    DEFF Research Database (Denmark)

    Andersen, Ove; Eugen-Olsen, Jesper; Kofoed, Kristian

    2008-01-01

    extend these findings by investigating the association of suPAR to glucose metabolic insufficiency during an oral glucose challenge (OGTT). METHODS: In 16 HIV-infected patients with lipodystrophy and 15 HIV-infected patients without lipodystrophy, glucose tolerance, insulin sensitivity (ISI......PAR correlated inversely with ISI(composite) and positively with 2h plasma glucose, fasting insulin secretion, fasting intact proinsulin and FFA level during the OGTT (all P...-RNA, duration of HIV infection), and dyslipidemia (plasma total cholesterol, triglyceride and free fatty acid level during the OGTT) were included, suPAR remained a significant marker of glucose tolerance and insulin sensitivity. Plasma suPAR exhibited a small CV (11%) during the 3h OGTT. CONCLUSIONS: su...

  12. Eficacia de los antivirales en la parálisis de Bell

    OpenAIRE

    Vázquez, María Cristina; Sánchez, Nury; Calvo, Judith; Perna, Abayubá

    2008-01-01

    Introducción: la parálisis de Bell es una afección frecuente que presenta en 15% de los casos una recuperación incompleta. En los últimos años se ha acumulado evidencia del posible rol del virus herpes simple tipo 1 en su etiología. Objetivos: comparar la eficacia de valaciclovir y prednisona versus prednisona placebo en la parálisis de Bell. Material y método: se realizó un ensayo prospectivo, randomizado y placebo controlado. De los 41 pacientes incluidos, 21 fueron tratados con valaciclovi...

  13. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...... of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI......) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  14. Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis.

    Science.gov (United States)

    Mannari, C; Santi, S; Migliori, M; Filippi, C; Origlia, N; Sansò, M; Boldrini, E; Giovannini, L

    2008-01-01

    Sucralfate is a drug used in the treatment of gastric and duodenal ulcer; it is cytoprotective and able to increase the bioavailability of several growth factors, modulating the wound healing process. In this study we tested the possible therapeutic effect of Sucralfate in the treatment of ulcerative lesions occurring in uterine cervix; to investigate such effect we used an experimental rat model of cervicitis in which the uPAR and EGFR expression were evaluated. Cervicitis was induced in wild and ovariectomized Wistar female rats by an acetic acid-soaked tampon. The animals were divided into two main groups (4 and 7 days) and Sucralfate was administered topically until the day they were sacrificed. In order to distinguish physiological and drug-induced healing, quantitative and qualitative uPAR and EGFR expression were evaluated by using Western blot and Immunohistochemistry techniques. Western blot analysis demonstrated an increased expression of both receptors after 4 days from wounding in wild and ovariectomized animals. In particular in ovariectomized animals the expression of uPAR and EGFR increased after 4 days while it reduced following the administration of Sucralfate. In wild rats the same was observed for uPAR expression, while EGFR was different; in fact, its expression increased significantly at day 4 in the animals treated with the drug and only at day 7 in those untreated. Immunohistochemistry highlighted a noteworthy epithelial colocalization of EGFR and uPAR after 4 days in the animals treated with Sucralfate. We conclude that Sucralfate can promote the healing of ulcerative cervicitis and moreover, it reduces the normal healing time because of its modulatory property on uPAR and EGFR expression.

  15. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran

    Directory of Open Access Journals (Sweden)

    Roghayeh Nouri

    Full Text Available Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75% of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates.

  16. Contribution de la tomographie par coherence optique au diagnostic ...

    African Journals Online (AJOL)

    Contribution de la tomographie par coherence optique au diagnostic de la neuropathie optique toxique. C.O.A. Abouki, S Alamou, C.R.A. Assavedo, L Odoulami-Yehouessi, I Sounouvou, S Hounnou-Tchabi ...

  17. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  18. Monoradiculopathy and secondary segmental instability caused by postoperative pars interarticularis fracture: a case report.

    Science.gov (United States)

    Kaner, Tuncay; Tutkan, Ibrahim

    2009-04-01

    Instability can develop after lumbar spinal surgery. What is also known as secondary segmental instability is one of the important causes of failed back syndrome. In this paper, we described a 45-year-old female patient who was diagnosed with secondary segmental instability caused by left L3 pars interarticularis fracture after a high lumbar disc surgery and was subsequently treated with re-operation. We evaluated the clinical course, diagnosis, and treatment methods for secondary segmental instability caused by postoperative pars interarticularis fracture. Furthermore, we emphasized the importance of preserving the pars interarticularis during upper lumbar disc surgeries in order to avoid a potential stress fracture.

  19. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Wilde, E.W.; Tilly, L.J.

    1985-02-01

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  20. De l'injure en pays maure ou « qui ne loue pas critique »

    Directory of Open Access Journals (Sweden)

    Catherine Taine-Cheikh

    2009-05-01

    Full Text Available Catherine Taine-Cheikh, qui s'intéresse au phénomène de l'injure dans la société arabophone de Mauritanie, commence par étudier les différents termes du dialecte hassâniyya qui relèvent de ce champ sémantique. Elle s'attache ensuite à montrer l'importance et la complexité de l'« effet injure », dans cette société fortement imprégnée par les valeurs de l'honneur où non seulement la critique mais aussi la louange peuvent apparaître comme des manifestations de l'injure. Passant en revue diverses situations empruntées à la vie quotidienne ou puisées dans des matériaux littéraires (écrits et surtout oraux, l'auteur relève diverses stratégies adoptées, soit par les injurieurs, soit par les injuriaires, pour tenter de maîtriser les effets des mots (ou gestes « déplacés ». Bien que le problème du contrôle de soi semble presque toujours primordial, la gestion de l'injure laisse apparaître une différenciation importante en fonction du sexe et du statut relatif des acteurs sociaux concernés.

  1. Par Pond refill water quality sampling

    International Nuclear Information System (INIS)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  2. A Mechanical Modelling of the Primary Migration Modélisation mécanique de l'expulsion

    Directory of Open Access Journals (Sweden)

    Schneider F.

    2006-12-01

    microfracturation induite par la génération des hydrocarbures dans les roches mères, nous proposons une méthode analytique pour déterminer l'évolution de la pression de l'huile. Cette méthode est basée sur une modélisation mécanique des interactions kérogène-huile-roche à l'échelle microscopique. Il est montré que la pression de l'huile tend vers une valeur asymptotique quand la réaction de transformation du kérogène en huile s'achève. Les variations des contraintes macroscopiques pendant la formation de l'huile ont des effets faibles. Cependant, ils doivent être considérés pour décrire correctement l'évolution de la pression de l'huile au stade précoce de la génération. L'augmentation de l'enfouissement provoque une augmentation de la pression de l'huile ainsi qu'une augmentation des contraintes macroscopiques. Cela conditionne l'évolution du champ de contraintes microscopiques. La possibilité de microfracturation dépend de la position du champ de contraintes microscopiques par rapport au critère de rupture. Si la durée de la transformation du kérogène en huile est suffisamment courte, de sorte que l'on puisse négliger la variation du champ de contraintes macroscopiques induite par la variation de l'enfouissement, alors, on montre que pour des valeurs usuelles des paramètres mécaniques, la microfracturation est possible. Néanmoins, de façon plus générale, le fait de négliger les variations du champ de contraintes macroscopiques conduit à une surestimation des possibilités de microfracturation induite par l'augmentation de la pression de l'huile. À l'échelle macroscopique (de la roche mère, l'équation qui décrit l'évolution de la pression de l'huile est écrite dans le cadre de la théorie poroélastique de Biot. L'évolution de la pression est donnée par la somme d'un terme de diffusion qui provient de la migration de l'huile dans la roche, et de deux termes respectivement associés à l'expansion volumique de la transformation du

  3. ParShield: A computer program for calculating attenuation parameters of the gamma rays and the fast neutrons

    International Nuclear Information System (INIS)

    Elmahroug, Y.; Tellili, B.; Souga, C.; Manai, K.

    2015-01-01

    Highlights: • Description of the theoretical method used by the ParShield program. • Description of the ParShield program. • Test and validation the ParShield program. - Abstract: This study aims to present a new computer program called ParShield which determines the neutron and gamma-ray shielding parameters. This program can calculate the total mass attenuation coefficients (μ t ), the effective atomic numbers (Z eff ) and the effective electron densities (N eff ) for gamma rays and it can also calculate the effective removal cross-sections (Σ R ) for fast neutrons for mixtures and compounds. The results obtained for the gamma rays by using ParShield were compared with the results calculated by the WinXcom program and the measured results. The obtained values of (Σ R ) were tested by comparing them with the measured results,the manually calculated results and with the results obtained by using MERCSFN program and an excellent agreement was found between them. The ParShield program can be used as a fast and effective tool to choose and compare the shielding materials, especially for the determination of (Z eff ) and (N eff ), there is no other programs in the literature which can calculate

  4. SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

    2018-01-01

    complications with a HR of 2.7 (95% CI 1.5 to 5.1, P=0.002), per doubling in suPAR. After adjusting for the European System for Cardiac Operative Risk Evaluation or Society of Thoracic Surgeons risk score, suPAR remained associated with postoperative mortality with a HR 3.2 (95% CI 1.2 to 8.6, P=0.025) and 2...

  5. Écoulement polyphasique dans un milieu poreux stratifié. Résultats expérimentaux et interprétation par la méthode de prise de moyenne à grande échelle Multiphase Flow in Stratified Porous Media Experimental Results and Interpretation by the Large-Scale Averaging Method

    Directory of Open Access Journals (Sweden)

    Bertin H.

    2006-11-01

    Full Text Available Nous abordons l'étude des écoulements polyphasiques en milieu poreux hétérogène d'un point de vue théorique (méthodologie de la prise de moyenne à grande échelle et expérimental. Dans une première partie nous présentons la méthodologie permettant d'obtenir les équations à grande échelle. Le point de départ de l'étude est les équations locales, analogues aux équations de Darcy généralisées obtenues par prise de moyenne des équations de Stokes à l'échelle du pore. La prise de moyenne à grande échelle de ces équations permet d'écrire un système d'équations où les coefficients de transport équivalents sont calculés à partir des données locales, par la résolution d'un problème de fermeture explicité dans le cas quasi-statique (effets capillaires dominants. La seconde partie de notre travail concerne l'étude expérimentale d'un écoulement eau-huile dans un milieu poreux stratifié constitué de deux régions de caractéristiques physiques différentes. Les champs de saturation bidimensionnels sont mesurés tout au long de l'imbibition par absorption d'un rayonnement gamma. Les résultats expérimentaux, évolution de la fraction volumique moyenne par section en fonction du temps, sont comparés aux résultats d'une simulation numérique des équations de transport où les coefficients utilisés ont été déterminés par la méthode de prise de moyenne à grande échelle. Two-phase flow in heterogeneous porous media is studied from a theoretical point of view (the large-scale averaging method and experimentally. In the first part, we present the methodology leading to the large-scale equations. The starting point of the study is the local equation, analogous to the generalized Darcy's law obtained by averaging the Stokes equation at the pore level. The large-scale averaging of these equations leads to a system where the equivalent transport coefficients are computed from the local data by solving a closure

  6. Results of Preliminary Tests of PAR Bunch Cleaning

    CERN Document Server

    Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S

    2005-01-01

    A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10

  7. Analysis of clinical features and visual outcomes of pars planitis.

    Science.gov (United States)

    Berker, Nilufer; Sen, Emine; Elgin, Ufuk; Atilgan, Cemile Ucgul; Dursun, Erdem; Yilmazbas, Pelin

    2018-04-01

    To evaluate the demographic characteristics, clinical features, treatment and outcomes of patients with pars planitis in a tertiary referral center in Turkey. Medical records of patients with pars planitis were retrospectively reviewed. The data including demographic and ocular features and treatment outcomes were recorded. The distribution of clinical findings and complications were evaluated according to age and gender groups. The changes in final BCVA compared to the initial BCVA were noted. Statistical analysis was performed using SPSS software (Version 18.0, SPSS Inc., Chicago, USA). Twenty-seven patients (54 eyes) were included in this study. 16 patients were male (59.3%), and 11 were female (40.7%). Mean age at diagnosis was 12.84 ± 8.26 (range 4-36) years. Mean follow-up period was 61.3 ± 52.15 (range 9-172) months. Mean BCVA was 0.58 ± 0.36 (range 0.03-1.00) (0.40 ± 0.45 logMAR) at presentation, and 0.81 ± 0.28 (range 0.10-1.00) (0.14 ± 0.27 logMAR) at final visit (P = 0.001). Vitreous inflammation (100%), vitreous haze (92.6%), snowballs (74.1%), snowbanks (66.7%), anterior chamber cells (66.7%) and peripheral retinal vascular sheathing (48.1%) were the most common presentations. Ocular complications included vitreous condensation (51.9%), cystoid macular edema (22.2%), cataract (18.5%), inferior peripheral retinal detachment (11.1%), glaucoma (5.6%) and vitreous hemorrhage (3.7%). Treatments included topical, periocular, intravitreal and systemic corticosteroids, immunosuppressives, peripheral laser photocoagulation and pars plana vitrectomy when needed. Pars planitis is an idiopathic chronic intermediate uveitis mostly affecting children and adolescents. In spite of its chronic nature with high potential of causing ocular complications, adequate treatment and close follow-up lead to favorable visual outcomes.

  8. Irreducible tensor operators and crystalline potentials; Operateurs tensoriels irreductibles et potentiels cristallins

    Energy Technology Data Exchange (ETDEWEB)

    Boutron, F; Saint-James, D [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    It is often accepted that the effects of its neighbourhood on the quantum state of an ion A may be obtained by the model of the crystalline effective field approximation. Within this assumption Stevens has developed a method which provides equivalent operators that facilitate the calculation of the matrix elements of the crystalline field in a given multiplicity. This method has been extended here. We demonstrate that in the expansion of the crystalline field in powers of the electrons coordinates of the ion A - for electrons of the same sub-shell of A - only even terms can contribute. Equivalent operators and matrix elements, in a given multiplicity, are given for these development terms - up to order 6 - and for potential invariant by the operations of one of the thirty-two point-groups. (author) [French] On admet souvent que l'effet de son entourage sur l'etat quantique d'un ion A peut etre obtenu a partir du concept de champ cristallin effectif. Dans le cadre de cette hypothese STEVENS a etabli une methode d'equivalence operatorielle qui facilite l'obtention des elements de matrice de ce champ cristallin dans une multiplicite donnee. Nous generalisons cette methode. Nous demontrons que, dans le developpement du champ cristallin en puissances successives des coordonnees des electrons d'une meme sous-couche de A, seuls les termes pairs doivent etre retenus. Nous donnons ensuite les equivalents operatoriels et les elements de matrice des termes de ce developpement (jusqu'a l'ordre 6), dans une multiplicite donnee, pour des potentiels invariants par les operations de l'un des trente-deux groupes ponctuels. (auteur)

  9. Could soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator-associated pneumonia?

    Science.gov (United States)

    Sunnetcioglu, Aysel; Sunnetcioglu, Mahmut; Adıyaman, Fırat; Binici, Irfan; Soyoral, Lokman

    2017-11-01

    Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that is increasingly used for evaluation of systemic inflammation. This study was performed to investigate whether suPAR may possess a diagnostic value in patients with ventilator-associated pneumonia (VAP). This clinical study was performed in the anesthesia intensive care units (ICUs) of our university. In addition to descriptive data, WBC, serum levels of C-reactive protein (CRP) and suPAR prior to and after development of VAP were noted and compared in 31 patients (22 men, 9 women) diagnosed with VAP (Study Group) and 19 patients without VAP (Control Group) in ICU (14 men, 5 women). The suPAR (P = 0.023), CRP (P = 0.037), WBCs (P = 0.024) in patients with VAP were significantly higher than patients without VAP. There was no remarkable difference in terms of WBCs (P = 0.052) and suPAR levels (P = 0.616) between groups on the first day of connection to mechanical ventilator. The suPAR and CRP levels in patients with VAP were significantly higher than prior to development of VAP (P = 0.001 for both). Area under curve value after diagnosis of pneumonia was found 0.248 (P = 0.002). To conclude, our results suggest that suPAR can be a useful diagnostic biomarker in patients with VAP. However, clinical trials on larger series are warranted to explore the clinical significance more accurately. © 2016 John Wiley & Sons Ltd.

  10. Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S; Lotlikar, A

    radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...

  11. Repérer des sites similaires à une recherche par Google

    OpenAIRE

    Ginouvès, Véronique

    2006-01-01

    Repérer des sites similaires à une recherche par Google Afficher graphiquement les liens d’un site avec d’autres sites similaires TouchGraph GoogleBrowser crée des agrégations de sites à partir de l’interrogation de Google. Vous visualisez ainsi des nébuleuses de sites à l’intérieur desquelles vous pouvez naviguer facilement, en sautant d'un groupe à l'autre afin de voir les nuages autour de sujets ou de communautés de sujets. Cet outil a été développé par Alex Shapiro, à partir de la version...

  12. Le dysfonctionnement socio-spatial des grands ensembles en Algérie: technique de l’analyse wayfinding par méthode “movement traces” et l’analyse morphologique (syntaxe spatiale par logiciel “depthmap”

    Directory of Open Access Journals (Sweden)

    Amara Hima

    2018-03-01

    Full Text Available Résumé La technique de l’analyse syntaxique de la visibilité (Visibility Graph Analysis – VGA et de l’accessibilité (All Line Analysis – ALA par logiciel “DepthMap©(UCL, Londres” et l’analyse du dysfonctionnement wayfinding par méthode “movement traces”, sont utilisées dans ce papier afin de développer un modèle d’analyse et d’investigation de l’impact des changements spatiaux sur le dysfonctionnement socio-spatial du wayfinding, ainsi sur la reproduction urbaine, notamment les transformations des façades et l’appropriation des espaces extérieurs dans les grands ensembles en Algérie. Nous donnons ici le cas d’étude de la cité 1000 logt-Biskra et la cité 500 logt-M’sila. Afin de vérifier cette hypothèse, un modèle d’analyse hybride a été développé par croisement des résultats d’analyses des deux techniques. Par conséquent, le schéma de l’interférence montre que la majorité des piétons préfèrent parcourir les axes courts et droits — caractérisés par une forte propriété syntaxique de visibilité et d’accessibilité (l’intégration, la connectivité et l’intelligibilité — en directions des équipements adjacents et aux milieux des deux cités. Ces itinéraires ont un impact sur les transformations des façades et l’appropriation des espaces extérieurs. Le modèle développé promet de futures recherches sur le plan de la quantification, la modélisation et la simulation du processus de la reproduction urbaine, notamment par les automates cellulaires.

  13. Effet de l'éloignement des champs sur la productivité du travail dans la culture du manioc en Afrique sub-Saharienne

    Directory of Open Access Journals (Sweden)

    Tshiunza, M.

    1997-01-01

    Full Text Available Effet de l'éloignement des champs sur la productivité du travail dans la culture du manioc en Afrique sub-Saharienne. Three soil tillage practices - summer ploughing, autumn ploughing and chisel - have been evaluated through their effect on soil physical characteristics and on water content during three months after wheat seeding. A comparison was made with no-tillage. This experiment has been conducted on a shallow calcareous clay soil during the season 1995-96. Primary field preparation allows a porous layer up to 20 cm depth which reduces bulk density and penetration resistance. All the profiles generated by the tillage implements were uniformed by the rain effect. The water content and distribution in the profile was significantly affected by the tillage implements. No-tillage allows the best distribution of water in the profile which is the most suitable to seed germination and plant stand. The increasing porosity due to the autumn tillage action reduced the amount of water stored in the soil in comparison with the no-tillage case.

  14. Infection par le VIH chez les patientes atteintes de cancer du sein en ...

    African Journals Online (AJOL)

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...

  15. A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets.

    Science.gov (United States)

    Sánchez Centellas, Daniel; Gudlur, Sushanth; Vicente-Carrillo, Alejandro; Ramström, Sofia; Lindahl, Tomas L

    2017-06-01

    Thrombin activates platelets via proteolytic cleavage of protease-activated receptors (PARs) 1 and 4. The two PARs have distinct but complementary roles. The mechanisms responsible for PAR1 activation by thrombin have been extensively studied. However, much less is known regarding thrombin activation of PAR4, especially the potential involvement of regions of PAR4 other than the N-terminal, which is bound to the catalytic site of thrombin. We have studied PAR4 in S. cerevisiae strain MMY12, an expression system in which the GPCR receptors are connected to a Lac Z reporter gene resulting in increased β-galactosidase activity. This approach was used to assess PAR4 mutants to evaluate the contribution of different aspartic residues in facilitating PAR4 activation. Furthermore, peptides mimicking parts of the PAR4 N-terminal and the second extracellular loop (ECLII) were tested for their ability to inhibit platelet activation by thrombin. Binding of these peptides to γ-thrombin was studied by monitoring the decrease in tryptophan fluorescence intensity of thrombin. We conclude that not only the N-terminal but also the electronegative aspartic residues D224, D230 and D235 (located in ECLII) are be important for PAR4 binding to thrombin. We further suggest that they play a role for the tethered ligand binding to the receptor, as mutations also affected activation in response to a PAR4-activating peptide mimicking the new N-terminal formed after cleavage. This agrees with previous results on PAR1 and thrombin binding. We suggest that the ECLII of PAR4 could be a potential target for antithrombotic drug development. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. The use of probe characteristics in plasma in the presence of a magnetic field (1960); Utilisation des caracteristiques de sondes dans des plasmas en presence de champ magnetique (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Brunet, A; Geller, R; Leroy, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    In this article we recall the principal methods of interpretation of probe characteristics in plasma in the presence of magnetic fields. Our purpose is to resume and to present the methods in such a form as to be immediately applicable in a particular case. This article is therefore principally useful to experimenters. Finally we expose our practical view points by comparing of experimental methods. (author) [French] Dans cet article, nous rappelons les principales methodes d'interpretation des caracteristiques de sonde dans des plasmas en presence de champs magnetiques. Notre but est de resumer et de presenter sous forme inmediatement applicable ces methodes. Cet article est donc destine aux experimentateurs. Enfin, nous developpons nos etudes pratiques sur la question en etablissant des comparaisons experimentales entre les methodes. (auteur)

  17. Fast Plasma from a Coaxial Gun; Plasma Rapide Produit par un Canon Coaxial; Bystraya plazma iz koaksial'nogo inzhektora; Produccion de Plasma Rapido Mediante un Inyector Coaxial

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, J.; Henins, I. [Los Alamos Scientific Laboratory, Los Alamos, NM (United States)

    1966-04-15

    volume around the jet. Fast plasma is emitted in a narrow conical distribution with an open centre. The high voltage which accelerates the fast deuterohs also accelerates wall material ions if the fast plasma bombards a glass wall and evaporates it. (author) [French] Le canon coaxial utilise dans cette experience est une source de deux plasmas differents produits par des mecanismes separes. Un plasma de deuterium abondant et lent ( Tilde-Operator 10{sup 7} cm/s) est produit directement par l'interaction du type j xli ou j est le courant de plasma radial et if le champ magnetique produit par le courant d'alimentation le long de l'electrode centrale. La perturbation de courant se deplace, a travers le gaz injecte, vers l'ouverture du canon, a une vitesse d'environ 2,5 * 10{sup 7} cm/s et emmagasine de l'energie a l'arriere sous forme de champ magnetique et d'energie cinetique de plasma. Par son energie emmagasinee, le canon fonctionne comme un generateur electrique de basse impedence et de grande puissance de maniere a lancer dans le vide au-dela de l'ouverture du canon un jet de courant qui est la source de plasma rapide ( Tilde-Operator 5 x 10{sup 17} deuterons, Tilde-Operator 10{sup 8} cm/s). Le jet de courant ainsi que le plasma qu'il produit font l'objet des experiences decrites dans ce memoire. Le mecanisme de l'acceleration est complique et n'est pas parfaitement connu, mais beaucoup d'enseignements ont ete tires d'un grand nombre d'experiences dans lesquelles ont ete utilises les diagnostics suivants: boucles de captage diamagnetique externes, boucles Rogowsky sous vide, sondes electriques, electrode de captage capacitive externe, analyse de la deflection magnetique et electrostatique de particules, spectroscopic, photographie de la lumiere emise par les cibles, mesure de temps de vol avec ou sans champ de guidage, neutrons emis par le volume,du plasma par suite de la reaction d-d, etc. Il en resulte que le mecanisme d'acceleration consiste en un processus magneto

  18. Preliminary Analysis For Wolsong Par Effects Using ISACC Calculations

    International Nuclear Information System (INIS)

    Song, Yong Mann; Kim, Dong Ha

    2012-01-01

    In the paper, hydrogen control effects using PARs only are analyzed for severe SBO station blackout (SBO) sequences beyond the design basis accidents in WS-1 which are of CANDU6 type reactor. As a computational tool, the latest version of ISAAC4.3 (Integrated Severe Accident Analysis Code for CANDU), which is a fully integrated and lumped severe accident computer code, is used to simulate hydrogen generation and transport inside the reactor building (R/B) before its failure. For the performance of hydrogen removal, the depletion rate equation of K-PAR developed in Korea is applied. In a CANDU reactor, three areas are identified as sources of hydrogen under severe accidents: fuel-coolant interactions in intact channels, suspended fuel or debris interactions in-calandria tank and debris interactions in-calandria vault. The first two origins provide source for the late ('late' terminology is used because it takes more than one day before calandria tank failure) potential hydrogen combustion before calandria tank failure and all the three origins would provide source for the very late potential hydrogen combustion occurring at or after calaria tank failure. If the hydrogen mitigation system fails, the AICC (adiabatic isochoric complete combustion) burning of highly flammable hydrogen may cause Wolsong R/B failure. So hydrogen induced failure possibility is evaluated, using preliminary ISAAC calculations, under several SBO conditions with and without PAR for both late and very late accident periods

  19. fortification des farines tropicales par l'introduction de proteines ...

    African Journals Online (AJOL)

    2Université d'Abomey Calavy, Faculté des Sciences et Techniques, Bénin ... valeur recommandée par le Codex Alimentarius pour ce type de complément alimentaire destiné aux enfants. ..... neurotransmission, coagulation sanguine et.

  20. Storm time dynamics of auroral electrojets: CHAMP observation and the Space Weather Modeling Framework comparison

    Directory of Open Access Journals (Sweden)

    H. Wang

    2008-03-01

    Full Text Available We investigate variations of the location and intensity of auroral currents during two magnetic storm periods based on magnetic field measurements from CHAMP separately for both hemispheres, as well as for the dayside and nightside. The corresponding auroral electrojet current densities are on average enhanced by about a factor of 7 compared to the quiet time current strengths. The nightside westward current densities are on average 1.8 (2.2 times larger than the dayside eastward current densities in the Northern (Southern Hemisphere. Both eastward and westward currents are present during the storm periods with the most intense electrojets appearing during the main phase of the storm, before the ring current maximizes in strength. The eastward and westward electrojet centers can expand to 55° MLat during intense storms, as is observed on 31 March 2001 with Dst=−387 nT. The equatorward shift of auroral currents on the dayside is closely controlled by the southward IMF, while the latitudinal variations on the nightside are better described by the variations of the Dst index. However, the equatorward and poleward motion of the nightside auroral currents occur earlier than the Dst variations. The Space Weather Modeling Framework (SWMF can capture the general dynamics of the storm time current variations. Both the model and the actual data show that the currents tend to saturate when the merging electric field is larger than 10 mV/m. However, the exact prediction of the temporal development of the currents is still not satisfactory.