Santeria and Palo Mayombe: skulls, mercury, and artifacts.

Science.gov (United States)

Gill, James R; Rainwater, Christopher W; Adams, Bradley J

2009-11-01

Santeria and Palo Mayombe are syncretic religions created in the New World based upon African religious beliefs combined with Christianity. The main worship of Palo Mayombe involves religious receptacles that may contain earth, sticks, varied artifacts, and animal and human remains. Due to the use of human and nonhuman remains, discovery of these items often leads to involvement by the police due to a concern of homicide. We review in detail the medical examiner records of two of these ritualistic cases including the autopsy, anthropology, police, and investigators' reports. For the human remains, careful consideration of the context in which the remains were recovered, their state of preservation, and the associated artifacts (e.g., beads and mercury) are important in determining the appropriate level of forensic significance. Anthropological examination with particular attention to taphonomic characteristics also may help determine the origin and forensic significance.

How Palo Verde saved millions of dollars

International Nuclear Information System (INIS)

Anon.

1994-01-01

In autumn 1992, Arizona Public Service adopted new project control procedures for outages at its three-unit Palo Verde PWR site, including: the switch to a PC-based environment; a new scheduling system; and the generation of improved graphics for decision making. Major cost savings were made and three further outages have now benefitted from the new systems. (author)

76 FR 1197 - Arizona Public Service Company, Palo Verde Nuclear Generating Station; Notice of Availability of...

Science.gov (United States)

2011-01-07

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-528, 50-529, 50-530; NRC-2009-0012] Arizona Public Service Company, Palo Verde Nuclear Generating Station; Notice of Availability of the Final Supplement 43... of operation for the Palo Verde Nuclear Generating Station (PVNGS). Possible alternatives to the...

U russkoi molodjozhi jest shans / Urve Palo ; interv. Ilja Gromov

Index Scriptorium Estoniae

Palo, Urve, 1972-

2008-01-01

Rahvastikuminister Urve Palo selgitab Avatud Ühiskonna Instituudi vene keelt kõnelevate noorte seas läbi viidud uuringu tulemusi. Lisa: Küsitlus: Kas vene keelt kõnelevatel noortel on Eestis hea elada

Palo Verde receives new control room simulator

International Nuclear Information System (INIS)

Anon.

1993-01-01

A new control room simulator was delivered to Arizona Public Service Company's Palo Verde nuclear generating station in late August. The system, the second simulator on site, will be used for training beginning in January 1994, said David C. Brown, manager of the simulator upgrade project. Having two simulators will ease the current tight training schedule, and allow expansion of instruction to personnel other than licensed operators

75 FR 13606 - Arizona Public Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

Science.gov (United States)

2010-03-22

... NUCLEAR REGULATORY COMMISSION [Docket Nos. STN 50-528, STN 50-529, and STN 50-530; NRC-2010-0114] Arizona Public Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3; Environmental...-74, issued to Arizona Public Service Company (APS, the licensee), for operation of the Palo Verde...

Major salt beds of the Palo Duro and Dalhart Basins, Texas

International Nuclear Information System (INIS)

1983-12-01

Major salt beds are defined as salt intervals at least 75 feet thick that contain no interbeds greater than 10 feet thick and include no more than 15 percent non-salt interbeds. Maps based on the interpretation of geophysical logs from hundreds of oil and gas exploration wells reveal seven major salt beds in the Palo Duro Basin and one major salt bed in the Dalhart Basin. The most extensive major salt beds are in the central and northern Palo Duro Basin, in the Upper San Andres Formation and the Lower San Andres Formation Units 4 and 5. Of these, the major salt bed within the Lower San Andres Formation Unit 4 is the most widespread and generally the thickest. 7 references, 15 figures, 2 tables

Options for In Situ Capping of Palos Verdes Shelf Contaminated Sediments

National Research Council Canada - National Science Library

Palermo, Michael; Schroeder, Paul; Rivera, Yilda; Ruiz, Carlos; Clarke, Doug; Gailani, Joe; Clausner, James; Hynes, Mary; Fredette, Thomas; Tardy, Barbara

1999-01-01

The U.S. Army Engineer Waterways Experiment Station (WES) has performed an evaluation of in situ capping options for sediment restoration of DDT and PCB contaminated sediments on the Palos Verdes (PV...

Risk-based inservice testing program modifications at Palo Verde nuclear generating station

International Nuclear Information System (INIS)

Knauf, S.; Lindenlaub, B.; Linthicum, R.

1996-01-01

Arizona Public Service Company (APS) is investigating changes to the Palo Verde Inservice Testing (IST) Program that are intended to result in the reduction of the required test frequency for various valves in the American Society of Mechanical Engineers (ASME) Section XI IST program. The analytical techniques employed to select candidate valves and to demonstrate that these frequency reductions are acceptable are risk based. The results of the Palo Verde probabilistic risk assessment (PRA), updated in June 1994, and the risk significant determination performed as part of the implementation efforts for 10 CFR 50.65 (the maintenance rule) were used to select candidate valves for extended test intervals. Additional component level evaluations were conducted by an 'expert panel.' The decision to pursue these changes was facilitated by the ASME Risk-Based Inservice Testing Research Task Force for which Palo Verde is participating as a pilot plant. The NRC's increasing acceptance of cost beneficial licensing actions and risk-based submittals also provided incentive to seek these changes. Arizona Public Service is pursuing the risk-based IST program modification in order to reduce the unnecessary regulatory burden of the IST program through qualitative and quantitative analysis consistent with maintaining a high level of plant safety. The objectives of this project at Palo Verde are as follows: (1) Apply risk-based technologies to IST components to determine their risk significance (i.e., high or low). (2) Apply a combination of deterministic and risk-based methods to determine appropriate testing requirements for IST components including improvement of testing methods and frequency intervals for high-risk significant components. (3) Apply risk-based technologies to high-risk significant components identified by the open-quotes expert panelclose quotes and outside of the IST program to determine whether additional testing requirements are appropriate

Risk-based inservice testing program modifications at Palo Verde nuclear generating station

Energy Technology Data Exchange (ETDEWEB)

Knauf, S.; Lindenlaub, B.; Linthicum, R.

1996-12-01

Arizona Public Service Company (APS) is investigating changes to the Palo Verde Inservice Testing (IST) Program that are intended to result in the reduction of the required test frequency for various valves in the American Society of Mechanical Engineers (ASME) Section XI IST program. The analytical techniques employed to select candidate valves and to demonstrate that these frequency reductions are acceptable are risk based. The results of the Palo Verde probabilistic risk assessment (PRA), updated in June 1994, and the risk significant determination performed as part of the implementation efforts for 10 CFR 50.65 (the maintenance rule) were used to select candidate valves for extended test intervals. Additional component level evaluations were conducted by an `expert panel.` The decision to pursue these changes was facilitated by the ASME Risk-Based Inservice Testing Research Task Force for which Palo Verde is participating as a pilot plant. The NRC`s increasing acceptance of cost beneficial licensing actions and risk-based submittals also provided incentive to seek these changes. Arizona Public Service is pursuing the risk-based IST program modification in order to reduce the unnecessary regulatory burden of the IST program through qualitative and quantitative analysis consistent with maintaining a high level of plant safety. The objectives of this project at Palo Verde are as follows: (1) Apply risk-based technologies to IST components to determine their risk significance (i.e., high or low). (2) Apply a combination of deterministic and risk-based methods to determine appropriate testing requirements for IST components including improvement of testing methods and frequency intervals for high-risk significant components. (3) Apply risk-based technologies to high-risk significant components identified by the {open_quotes}expert panel{close_quotes} and outside of the IST program to determine whether additional testing requirements are appropriate.

Area geological characterization report for the Palo Duro and Dalhart Basins, Texas

International Nuclear Information System (INIS)

1983-07-01

The present state of knowledge of the geology, hydrogeology, and seismology of the Palo Duro and Dalhart basins is summarized as a basis for future siting studies for a high-level nuclear waste repository. Large portions of the Texas Panhandle, and especially the Palo Duro basin, have stable geologic conditions and a favorable evaporite stratigraphy that warrant further study. Five salt-bearing formations containing thick salt units are present within the basin. Salt beds appear to be persistent over wide areas, relatively flat lying and structurally undisturbed. Available hydrogeologic data suggest that favorable conditions for waste isolation are widespread. The level and rate of seismic activity are low throughout the Texas Panhandle. 335 references, 83 figures, 17 tables

Assessment of vibration anomalies of main steam lines at Palo Verde-3

International Nuclear Information System (INIS)

Amr, A.; Landstrom, C.; Maxwell, H.; Miller, J.S.; Lynch, J.J.

1996-01-01

Historically, flow induced vibration in piping systems that transport liquid has presented problems for plant designers. When evaluating a vibration problem, it is always important to determine the forcing frequencies from different phenomena and the natural frequencies of the system as an integral part of establishing the root cause of the problem. Since in most cases of large vibration and noise levels, the natural frequency of the system and the frequency of the flow induced vibration are very close, determining the natural frequency of the system is important. Palo Verde Unit-3 exhibited a vibration problem where identification of the root cause was difficult. A Palo Verde team was created which consisted of engineers from different on-site departments and support from consultants. The process used to determine the root cause for the vibration/noise problem on Main Steam Supply System (MSSS) steam line 2 at Palo Verde Unit 3 is discussed in this paper. Since the root cause was not readily apparent, a finite element model was constructed to determine the natural frequency of the piping system. The finite element model consisted of a portion of the main steam lines, including a sample line which traverses the main steam line

Complejo de restauración del atún rojo en Cabo de Palos : CRARCP

OpenAIRE

Denchev Torlakov, Ivaylo

2016-01-01

El proyecto pretende por una parte poner en valor el producto del atún rojo promocionando los nuevos valores de la cocina (I+D+I) y convertirlo en símbolo de identidad para el municipio de Cabo de Palos y la Región de Murcia. Por otra parte se busca la reactivación y definición de un borde urbano en Cabo de Palos. Para ello se definen los siguientes objetivos: - Analizar el entorno urbano existente, evaluarlo y proponer soluciones que permitan mejorar las condiciones del mismo, impulsando la ...

The PALOS project and its significance for industrial application

Energy Technology Data Exchange (ETDEWEB)

Guzzella, L. [Swiss Federal Institute of Technology Zuerich (ETHZ), Institute for Measurement and Control Laboratory (IMRT), Zuerich (Switzerland); Spring, P. [Swiss Federal Institut of Technology Zuerich (ETHZ), Institut fuer Mess- und Regeltechnik, Zuerich (Switzerland)

2001-07-01

This report compiled by the Swiss Federal Institute of Technology ETH introduces the PALOS (PArt Load Optimised System) concept for a downsized supercharged engine. The authors note that a mid-class passenger car needs an average power at the wheel of only 4.5 kW for typical driving cycles. For acceleration from 0 to 100 km/h within 10 seconds, however, the same vehicle requires a wheel power of approximately 120 kW. Thus, the engine efficiency is low under part load driving conditions. The objectives of the PALOS project are discussed as are methods to increase engine systems efficiency. Close collaboration with industrial partners during the whole project that lead to a high level of know-how transfer from university to industry and vice versa is noted. Four PhD theses on the subject are summarised: Part-load optimised engine systems, engine thermo-management for fuel consumption reduction, optimal operation of CVT-based powertrains and mean value modelling of a pressure wave supercharger (PWS), including exhaust gas recirculation, is looked at.

75 FR 8149 - Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

Science.gov (United States)

2010-02-23

...] Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3... NPF-74, issued to the Arizona Public Service Company (APS, or the licensee), for operation of the Palo Verde Nuclear Generating Station (PVNGS, the facility), Units 1, 2, and 3, respectively, located in...

La metáfora en las fronteras filosóficas

Directory of Open Access Journals (Sweden)

Antonio Correa Iglesias

2005-01-01

Full Text Available La relación que siempre ha existido entre la filosofía y el lenguaje es una zona que nos interesa explorar. La imagen de la metáfora como figura que se contextualiza en este ensayo, tiene como presupuesto el origen occidental del acto especular y la concurrencia que lo metafórico ha tenido en este tan particular período del pensamiento. Lo metafórico, entonces, se convierte en el nudo gordiano que se comienza a develar en tanto esta problematización hace aparición en el texto poético como fuente generatriz de lo que posteriormente será el discurso filosófico occidental, que en su lectura fundacional atisba el caos pero cae con posterioridad en un irreversible proceso de secularización en el cual la metáfora también jugó y juega hasta hoy un muy importante desempeño

Seasonal patterns in metazoan parasite community of the "Fat Sleeper" Dormitator latifrons (Pisces: Eleotridae from Tres Palos Lagoon, Guerrero, Mexico

Directory of Open Access Journals (Sweden)

Juan Violante-González

2008-09-01

Full Text Available Dormitator is among the most important fish genera in the Mexican Pacific coastal lagoon systems. In Tres Palos Lagoon, the Fat Sleeper Dormitator latifrons is one of the most significant species based on catch volume, although it is only consumed locally. Very little information exists on this species’ parasitofauna. Composition and temporal variation in the metazoan parasite community structure of Dormitator latifrons from Tres Palos Lagoon (99º47’ W, 16º48’ N, Guerrero, Mexico, were determined using seasonal samples taken between April 2000 and June 2002. Ten parasite species (55 817 individuals were recovered from 219 examined hosts. These species included eight helminths (Ascocotyle (Phagicola longa, Echinochasmus leopoldinae, Clinostomum complanatum, Pseudoacanthostomum panamense, Saccocoelioides lamothei, Parvitaenia cochlearii, Contracaecum sp. and Neoechinorhynchus golvani and two crustaceans (Argulus sp. and Ergasilus sp.. Five of the helminth species exhibited seasonal variation in their infection dynamics associated with environmental changes during the dry and rainy seasons. The variations in the infection dynamics generated changes in the community structure over time. Rev. Biol. Trop. 56 (3: 1419-1427. Epub 2008 September 30.Entre abril del 2000 y junio del 2002 se efectuó un estudio para determinar la composición y la variación temporal en la estructura de la comunidad de parásitos metazoarios del popoyote Dormitator latifrons en la laguna de Tres Palos, Guerrero, México, a partir de muestras temporales. Se recuperaron diez especies de parásitos (55 817 individuos de 219 hospederos examinados. Estas especies incluyeron ocho helmintos (Ascocotyle (Phagicola longa, Echinochasmus leopoldinae, Clinostomum complanatum, Pseudoacanthostomum panamense, Saccocoelioides lamothei, Parvitaenia cochlearii, Contracaecum sp. y Neoechinorhynchus golvani y dos crustáceos (Argulus sp. y Ergasilus sp.. Cinco de las especies de

Les enjeux écologiques de Palo Verde (Costa Rica

Directory of Open Access Journals (Sweden)

Bertrand LÉVY

1992-09-01

Full Text Available Près de Palo Verde a été créé un parc naturel. Un projet d’irrigation risque de perturber l’écologie de la région. Une carte de son écosystème a été établie par télédétection, pour évaluer l’impact d’un tel projet.

Radioactive waste isolation in salt: peer review of the Office of Nuclear Waste Isolation's reports on preferred repository sites within the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Fenster, D.; Edgar, D.; Gonzales, S.; Domenico, P.; Harrison, W.; Engelder, T.; Tisue, M.

1984-04-01

Documents are being submitted to the Salt Repository Project Office (SRPO) of the US Department of Energy (DOE) by Battelle Memorial Institute's Office of Nuclear Waste Isolation (ONWI) to satisfy milestones of the Salt Repository Project of the Civilian Radioactive Waste Management Program. Some of these documents are being reviewed by multidisciplinary groups of peers to ensure DOE of their adequacy and credibility. Adequacy of documents refers to their ability to meet the standards of the US Nuclear Regulatory Commission, as enunciated in 10 CFR 60, and the requirements of the National Environmental Policy Act and the Nuclear Waste Policy Act of 1982. Credibility of documents refers to the validity of the assumptions, methods, and conclusions, as well as to the completeness of coverage. This report summarizes Argonne's review of ONWI's two-volume draft report entitled Identification of Preferred Sites within the Palo Duro Basin: Vol. 1 - Palo Duro Location A, and Vol. 2 - Palo Duro Location B, dated January 1984. Argonne was requested by DOE to review these documents on January 17 and 24, 1984 (see App. A). The review procedure involved obtaining written comments on the reports from three members of Argonne's core peer review staff and three extramural experts in related research areas. The peer review panel met at Argonne on February 6, 1984, and reviewer comments were integrated into this report by the review session chairman, with the assistance of Argonne's core peer review staff. All of the peer review panelists concurred in the way in which their comments were represented in this report (see App. B). A letter report and a draft of this report were sent to SRPO on February 10, 1984, and April 17, 1984, respectively. 5 references

El deslizamiento de Palo Alto, Turrialba, Costa Rica : apuntes para su estudio

Directory of Open Access Journals (Sweden)

Peraldo Huertas, Giovanni

2015-12-01

álisis de las morfologías del terreno se determinó que, dentro la forma típica en herradura que muestra este deslizamiento, se pueden distinguir 4 unidades: 1. Escarpes internos, 2. Bloques basculados, 3. Coronas laterales del deslizamiento y 4. Áreas de depósito de los materiales deslizados. El deslizamiento posee una serie de escarpes alargados, algunos llegan a medir aproximadamente 10 a 15 metros de altura. Al noroeste de Peralta se observan una serie de bloques, algunos alargados y otros con una forma más ovalada, los cuales se encuentran basculados en dirección NW, así como algunas zonas planas que, mediante comprobación de campo se determinó que corresponden en su mayoría con zonas anegadas. Se observan también colinas redondeadas, algunas alargadas, aisladas y en medio de ellas áreas deprimidas. Las morfologías de depositación presentan pendientes suaves, no mayores a los 10°, y onduladas. Entre los efectos que se generan por el movimiento en bloques en el área del deslizamiento, se encuentran repeticiones en la secuencia litológica y alteraciones en el patrón de drenaje existente. El hecho de que el río Guaitil discurra dentro del área del deslizamiento Palo Alto, hace un llamado de atención, ya que se observó la presencia de fisuras abiertas en su cauce que permiten la filtración de agua, lo que lleva a suponer que el deslizamiento esté en proceso de reactivación. Además, ante la posible reactivación económica que el proyecto Reventazón causará en el área, es importante generar más investigación para efectos de ordenamiento territorial y de gestión del riesgo This paper seeks to characterize Palo Alto landslide, from a geological and geomorphological point of view, in the context of mega-slope instability processes present along the Reventazón River. The Reventazón River corridor, between Turrialba and Siquirres, shows a series of complex mass movement processes, which generate continuous landslide related morphologies, giving

Geotechnical materials considerations for conceptual repository design in the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Versluis, W.S.; Balderman, M.A.

1984-01-01

The Palo Duro Basin is only one of numerous potential repository locations for placement of a nuclear waste repository. Conceptual designs in the Palo Duro Basin involve considerations of the character and properties of the geologic materials found on several sites throughout the Basin. The first consideration presented includes current basin exploration results and interpretations of engineering properties for the basin geologic sequences. The next consideration presented includes identification of the characteristics of rock taken from the geologic sequence of interest through laboratory and field testing. Values for materials properties of representative samples are obtained for input into modeling of the material response to repository placement. Conceptual designs which respond to these geotechnical considerations are discussed. 4 references, 4 figures, 4 tables

Identification of sites within the Palo Duro Basin. Volume 1. Palo Duro Location A

International Nuclear Information System (INIS)

1984-11-01

This three-volume document narrows to two sites for continued investigations for potential nuclear waste repository sites in the Palo Duro Basin of the Texas Panhandle. Volume 1 narrows a site previously identified in Deaf Smith County, Texas; Volume 2 narrows a site previously identified in Swisher County, Texas; and Volume 3 contains responses to comments received regarding the drafts of Volumes 1 and 2 (BMI/ONWI-531). These volumes discuss the methodology and logic used as well as the results that narrowed these sites. Each of the 10 site performance criteria was divided into descriptors related to site performance characteristics. Each descriptor was evaluated by a systematic logic to determine if it could be used as a discriminator. Then more- and less-preferred areas for groups of discriminators were defined and composite maps were prepared and evaluated to identify the sites

Identification of sites within the Palo Duro Basin. Volume 2. Palo Duro Location B

International Nuclear Information System (INIS)

1984-11-01

This three-volume document narrows to two sites for continued investigations for potential nuclear waste repository sites in the Palo Duro Basin of the Texas Panhandle. Volume 1 narrows a site previously identified in Deaf Smith County, Texas; Volume 2 narrows a site previously identified in Swisher County, Texas; and Volume 3 contains responses to comments received regarding the drafts of Volumes 1 and 2 (BMI/ONWI-531). These volumes discuss the methodology and logic used as well as the results that narrowed these sites. Each of the 10 site performance criteria was divided into descriptors related to site performance characteristics. Each descriptor was evaluated by a systematic logic to determine if it could be used as a discriminator. Then more- and less-preferred areas for groups of discriminators were defined and composite maps were prepared and evaluated to identify the sites

Active basement uplift as seen with cosmogenic lenses: the Sierra Pie de Palo case (Western Argentina)

Science.gov (United States)

Siame, L. L.; Sébrier, M.; Costa, C. H.; Ahumada, E. A.; Bellier, O.

2013-12-01

The Andean foreland of western Argentina (28°S-33°S) corresponds to retroarc deformations associated with the ongoing flat subduction of the Nazca plate beneath the South American lithosphere, and associated with high levels of seismic activity and crustal active faulting. To improve earthquake source identification and characterization in the San Juan region, data from seismology, structural geology and quantitative geomorphology can be integrated and combined to provide a seismotectonic model. In this model, the Andean back-arc of western Argentina has to be regarded as an obliquely converging foreland where Plio-Quaternary deformations are partitioned between strike-slip and thrust motions that are localized on the E-verging, thin-skinned Argentine Precordillera, and the W-verging thick-skinned Sierras Pampeanas, respectively. In this domain, the Sierra Pie de Palo is a key structure playing a major role in the partitioning of the Plio-Quaternary deformations. Located in the westernmost Sierras Pampeanas, the Sierra Pie de Palo forms a NNE striking, 80 km-long and 35-40 km-wide, ellipsoid range that reaches elevation as high as 3162 m. This mountain range is an actively growing basement fold associated with a high level of seismic activity (e.g., the November 23, 1977, Caucete, Mw 7.4 earthquake). To evaluate the degree of tectonic activity around the Sierra Pie de Palo, we combined a detailed morphometric analysis of the topography together with in situ-produced cosmogenic 10Be concentrations measured in (1) bedrock outcrops corresponding to the exhumed erosional regional surface, (2) surface boulders abandoned on alluvial fans deformed by active faults, and (3) in fluvial sediments sampled at the outlets of selected watersheds that drains out from the Sierra Pie de Palo. All together, our results allows: (1) assessing quantitative constraints on the rate of tectonic and denudation processes that are responsible for the active growth and erosion of the Sierra

Area environmental characterization report of the Dalhart and Palo Duro basins in the Texas Panhandle. Volume II. Palo Duro basin

International Nuclear Information System (INIS)

1982-09-01

This area report describes the environmental characteristics of the Dalhart and Palo Duro basins of the Texas Panhandle portion of the Permian basin. Both basins are rather sparsely populated, and the overall population is decreasing. The economic base is centered on agribusiness and manufacturing. Most of the potentially conflicting land uses in both basins (i.e., parks, historic sites) occupy small land areas, with the exception of a national grassland in the Dalhart and military air training routes in both basins. Ground transportation in the Dalhart basin is adequate, and it is well developed in the Palo Duro basin. In both basins irrigation constitutes the principal water use, and groundwater is the principal source. However, the dominant aquifer, the Ogallala, is being depleted. Both basins consist primarily of grasslands, rangelands, and agricultural areas. No critical terrestrial or aquatic habitats have been identified in the basins, though several endangered, threatened, or rare terrestrial species occur in or near the basins. Aquatic resources in both basins are limited because of the intermittent availability of water and the high salt content of some water bodies. Playa lakes are common, though usually seasonal or rain dependent. The climate of the area is semiarid, with low humidity, relatively high wind speeds, and high variable precipitation. Restrictive dispersion conditions are infrequent. National ambient secondary air quality standards for particulates are being exceeded in the area, largely because of fugitive dust, although there are some particulate point sources

Macroinvertebrados bentónicos del humedal de Palo Verde, Costa Rica

Directory of Open Access Journals (Sweden)

F.A Trama

2009-11-01

Full Text Available El humedal de Palo Verde es uno de los más importantes de Centro America para aves acuáticas. Durante el período 2002 y 2005, se llevaron a cabo actividades de manejo para controlar la invasión de Typha domingensis. Con el fin de establecer una línea base para monitoreos futuros, en el 2003 se realizó una evaluación de macroinvertebrados acuáticos. Se efectuó un muestreo mensual durante un año, usando el método de sustratos artificiales. Se identificaron 116 táxones pertenecientes a 47 familias y a 18 órdenes. La mayor abundancia se encontró en la clase Conchostraca y la familia Chironomidae que juntas representaron casi la mitad de todos los individuos colectados. En contraste, el 97% de los táxones tuvieron, cada uno, menos del 1% del total de la abundancia. La diversidad de táxones, así como la abundancia de individuos y el número de especies, fueron mayores en la época seca que en la lluviosa. La curva acumulada de especies indicó que se hubiera registrado una mayor cantidad de táxones si los muestreos se hubieran extendido por más tiempo. Con este trabajo damos a conocer la primera lista de macroinvertebrados para el humedal de Palo Verde.Benthic macroinvertebrates of the Palo Verde wetland, Costa Rica. Palo Verde, Costa Rica, is one of the most important wetlands in the region now recovering from some invasive plants, especially Typha domingensis, and monitoring programs were started, including studies on the aquatic macoinvertebrate fauna. We sampled benthic macroinvertebrates monthly for more than a year with artificial substrates, and identified 116 taxa from 57 families and 18 orders, with 90 morfospecies of insects. The highest abundances were in the class Conchostraca (typical in seasonal wetlands and in the family Chironomidae (Diptera, Insecta, which together represent almost half of all individuals collected. In contrast, 97 taxa were less than 1% of total abundance each. Number of individuals and number of

Update-processing steam generator cleaning solvent at Palo Verde

International Nuclear Information System (INIS)

Peters, G.

1996-01-01

Framatome Technologies Inc.(FTI) recently completed the steam generator chemical cleanings at the Palo Verde Nuclear Generating Station Units 1, 2 and 3. Over 500,000 gallons of low-level radioactive solvents were generated during these cleanings and were processed on-site. Chemical cleaning solutions containing high concentrations of organic chelating wastes are difficult to reduce in volume using standard technologies. The process that was ultimately used at Palo Verde involved three distinct processing steps: The evaporation step was conducted using FTI's submerged combustion evaporator (SCE) that has also been successfully used at Arkansas Nuclear One - Unit 1, Three Mile Island - Unit 1, and Oconee on similar waste. The polishing step of the distillate used ultrafiltration (UF) and reverse osmosis (RO) technology that was also used extensively by Ontario Hydro to assist in their processing of chemical cleaning solvent. This technology, equipment, and operations personnel were provided by Zenon Environmental, Inc. The concentrate from the evaporator was absorbed with a special open-quotes peat mossclose quotes based media that allowed it to be shipped and buried at the Environcare of Utah facility. This is the first time that this absorption media or burial site has been used for chemical cleaning solvent

Perekond on kõige tähtsam / Urve Palo

Index Scriptorium Estoniae

Palo, Urve, 1972-

2007-01-01

Ilmunud ka: Hiiu Leht, 21. dets. 2007, lk. 2; Pärnu Postimees, 21. dets. 2007, lk. 15; Severnoje Poberezhje, 21. dets. 2007, lk. 2; Nädalaleht, 21. dets. 2007, lk. 2; Koit, 22. dets. 2007, lk. 6; Meie Maa, 22. dets. 2007, lk. 2; Molodjozh Estonii, 29. dets. 2007, lk. 4; Võrumaa Teataja, 5. jaan. 2008, lk. 3; Järva Teataja, 5. jaan. 2008, lk. 2. Rahvastikuminister Urve Palo jõulu- ja aastalõputervitus

Lo uno y lo diverso

Directory of Open Access Journals (Sweden)

José Rojas Bez

2015-01-01

Full Text Available El arte no solo tiene ese poder para agudizar las miradas Toda creación, apreciación y educación artística está vinculada a una observación y comprensión más incisiva y honda del hombre y del mundo. Al arte y a la educación estética corresponde, pues, un importante papel en esta rica dialéctica entre lo singular y lo universal, en la creación y apreciación de lo uno en lo diverso y de la diversidad en la unidad.

Human factors engineering control-room-design review/audit report: Palo Verde Nuclear Generating Station, Arizona Public Service Company

International Nuclear Information System (INIS)

Savage, J.W.; Lappa, D.A.

1981-01-01

A human factors engineering design review of the Palo Verde control room simulator was performed at the site on September 15 through September 17, 1981. Observed human factors design discrepancies were given priority ratings. This report summarizes the team's observations of the control room design and layout and of the control room operators' interface with the control room environment. A list of the human factors strengths observed in the Palo Verde control room simulator is given

Metáfora, ciencia y cultura: Propuesta de una nueva tipología para el análisis de la metáfora científica

Directory of Open Access Journals (Sweden)

Georgina Cuadrado Esclapez

2004-04-01

Full Text Available Este artículo de carácter interdisciplinar establece una correlación entre los modos cognitivos (Buxó Rey, 1975; 1984 y la metáfora en la ciencia, lo que supone la incorporación de una importante aportación de la antropología cognitiva a la teoría del lenguaje y del conocimiento. Para establecer esta correlación, se parte del supuesto de que el modo de pensar y de estructurar la realidad de una determinada cultura no está separado de su manifestación en el lenguaje y, por tanto, de la construcción de concepciones metafóricas. Esta correlación sólo es posible partiendo de las premisas establecidas por la última generación cognitivista que asume que la metáfora es parte constituyente de nuestro sistema conceptual (Gleitman & Lieberman, 1995; Smith & Osherson, 1995. La tipología que propone espera ofrecer nuevas perspectivas para el análisis de la metáfora en el discurso científico-técnico.

Multispectral image analysis of the Palo Duro Basin, Texas: Final report

International Nuclear Information System (INIS)

Andre, C.G.

1986-09-01

The objectives of this remote sensing study of the Palo Duro Basin are to: (1) detect the surface expression of regional subsurface structure; (2) locate previously unrecognized fractures; (3) interpret the data in terms of the geologic history of the Palo Duro Basin. Linear and circular surface features were mapped from Landsat 4 Thematic Mapper and NOAA-7 Advanced Very High Resolution Radiometer digital images of visible, near-infrared and thermal infrared bands. The density and orientation of features mapped are shown to be related to geological features, such as faults, structural arches, paleoerosion topography and salt dissolution zones. The approximate area covered by the three 185 km /times/ 170 km Thematic Mapper images studied extends southward from the Canadian River Breaks to the Sand Hills and eastward from the western Mountains in Oklahoma. The day and night thermal infrared images from the NOAA-7 satellite encompass an area that includes the northern half of Texas and most of the surrounding states to the east, west and north. 4 refs

Kodanikupäev, kas ainult kalendri jaoks? / Urve Palo

Index Scriptorium Estoniae

Palo, Urve, 1972-

2007-01-01

Ilmunud ka: Põhjarannik, 13. nov. 2007, lk. 4; Severnoje Poberezhje, 13. nov. 2007, lk. 4; Meie Maa, 13. nov. 2007, lk. 2; Valgamaalane, 13. nov. 2007, lk. 2; Nädalaleht, 9. nov. 2007, lk. 8; Lääne Elu, 15. nov. 2007, lk. 2; Koit, 15. nov. 2007, lk. 6; Virumaa Teataja, 22. nov. 2007, lk. 2; Pärnu Postimees, 24. nov. 2007, lk. 19. Rahvastikuminister Urve Palo sõnul on riigi ülesanne kindlustada turvaline Eesti riik - keskkond elamiseks, õppimiseks, töötamiseks, laste kasvatamiseks ning ühiskondlikuks tegevuseks

First status report on regional groundwater flow modeling for the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Andrews, R.W.

1984-12-01

Regional groundwater flow within the principal hydrogeological units of the Palo Duro Basin is evaluated by developing a conceptual model of the flow regime in the shallow aquifers and the deep-basin brine aquifers and testing these models using a three-dimensional, finite-difference flow code. Semiquantitative sensitivity analysis (a limited parametric study) is conducted to define the system response to changes in hydrologic properties or boundary conditions. Adjoint sensitivity analysis is applied to the conceptualized flow regime in the Wolfcamp carbonate aquifer. All steps leading to the final results and conclusions are incorporated in this report. The available data utilized in this study are summarized. The specific conceptual models, defining the areal and vertical averaging of lithologic units, aquifer properties, fluid properties, and hydrologic boundary conditions, are described in detail. The results are delineated by the simulated potentiometric surfaces and tables summarizing areal and vertical boundary fluxes, Darcy velocities at specific points, and groundwater travel paths. Results from the adjoint sensitivity analysis included importance functions and sensitivity coefficients, using heads or the average Darcy velocities as the performance measures. The reported work is the first stage of an ongoing evaluation of two areas within the Palo Duro Basin as potantial repositories for high-level radioactive wastes. The results and conclusions should thus be considered preliminary and subject to modification with the collection of additional data. However, this report does provide a useful basis for describing the sensitivity and, to a lesser extent, the uncertainty of the present conceptualization of groundwater flow within the Palo Duro Basin

Capturing the design bases on Palo Verde

International Nuclear Information System (INIS)

Rogers, A.C.; Prawlocki, F.C.

1989-01-01

Over the past several years, the nuclear power industry has been directing considerable attention to plant configuration control. Utilities have been put in difficult situations due to changes made in plants without full original design basis knowledge. Once a plant is constructed, there is often insufficient information from the reactor designer or the architect/engineer to properly support operations, especially changes to the plant. In many cases utilities do not know the design bases for their units. As a result of these concerns, many utilities have been searching for ways to define the appropriate design bases for their plant. This paper discusses steps taken by Palo Verde to produce a design bases document and how it is being used to support the operation of the three nuclear units

Metáfora y conceptos abstractos

OpenAIRE

Danesi, Marcel

2006-01-01

La gran cantidad de datos recolectados sobre la metáfora sugiere enfáticamente que muchos de los conceptos abstractos, si no la mayoría, son codificables y reconocibles primordialmente como «ideas metaforizadas», es decir como conceptos que se derivan cognitivamente mediante el razonamiento metafórico y un proceso de asociación metafórica que en este artículo se denominará estratificación [layering] (Gibbs, 1994; Goatley, 1997). La literatura más actualizada sobre lo que se ha denominado Teor...

Coriocarcinoma con metástasis pulmonar

Directory of Open Access Journals (Sweden)

Vicia Sánchez Abalos

2014-05-01

Full Text Available Se presenta el caso clínico de una fémina de 44 años de edad, con 32 semanas de embarazo, la cual fuera ingresada en la Unidad de Cuidados Intensivos del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, por presentar insuficiencia respiratoria aguda como consecuencia de una sepsis. La paciente fue tratada con cefalosporina de tercera generación y ventilación mecánica no invasiva, pero se mantuvieron las características gasométricas de hipoxemia y una mala reacción terapéutica, por lo que se requirió instrumentación de las vías respiratorias y soporte hemodinámico, sin lograr regresión del cuadro clínico, lo cual condujo a un paro cardiorrespiratorio y, con ello, a la muerte. La necropsia mostró un coriocarcinoma del endometrio con metástasis pulmonar

Macroinvertebrados bentónicos del humedal de Palo Verde, Costa Rica

Directory of Open Access Journals (Sweden)

F.A Trama

2009-11-01

Full Text Available El humedal de Palo Verde es uno de los más importantes de Centro America para aves acuáticas. Durante el período 2002 y 2005, se llevaron a cabo actividades de manejo para controlar la invasión de Typha domingensis. Con el fin de establecer una línea base para monitoreos futuros, en el 2003 se realizó una evaluación de macroinvertebrados acuáticos. Se efectuó un muestreo mensual durante un año, usando el método de sustratos artificiales. Se identificaron 116 táxones pertenecientes a 47 familias y a 18 órdenes. La mayor abundancia se encontró en la clase Conchostraca y la familia Chironomidae que juntas representaron casi la mitad de todos los individuos colectados. En contraste, el 97% de los táxones tuvieron, cada uno, menos del 1% del total de la abundancia. La diversidad de táxones, así como la abundancia de individuos y el número de especies, fueron mayores en la época seca que en la lluviosa. La curva acumulada de especies indicó que se hubiera registrado una mayor cantidad de táxones si los muestreos se hubieran extendido por más tiempo. Con este trabajo damos a conocer la primera lista de macroinvertebrados para el humedal de Palo Verde.

Palos Verdes Shelf oceanographic study; data report for observations December 2007–April 2008

Science.gov (United States)

Rosenberger, Kurt J.; Noble, Marlene A.; Sherwood, Christopher R.; Martini, Marinna M.; Ferreira, Joanne T.; Montgomery, Ellyn T.

2011-01-01

Beginning in 1997, the Environmental Protection Agency (EPA) defined a contaminated section of the Palos Verdes Shelf region in southern California as a Superfund Site, initiating a continuing investigation of this area. The investigation involved the EPA, the U.S. Geological Survey (USGS), Science Applications International Corporation (SAIC), Los Angeles County Sanitation Districts (LACSD) data, and other allied agencies. In mid-2007, the Palos Verdes Shelf project team identified the need for additional data on the sediment properties and oceanographic conditions at the Palos Verdes Superfund Site and deployed seven bottom platforms, three subsurface moorings, and three surface moorings on the shelf. This additional data was needed to support ongoing modeling and feasibility studies and to improve our ability to model the fate of the effluent-affected deposit over time. It provided more detail on the spatial variability and magnitude of resuspension of the deposit during multiple storms that are expected to transit the region during a winter season. The operation began in early December 2007 and ended in early April 2008. The goal was to measure the sediment response (threshold of resuspension, suspended-sediment concentrations, and suspended-sediment transport rates) to bed stresses associated with waves and currents. Other objectives included determining the structure of the bottom boundary layer (BBL) relating nearbed currents with those measured at 10 m above bottom (mab) and comparing those with the long-term data from the LACSD Acoustic Doppler Current Profiler (ADCP) deployments for nearbed current speed and direction. Low-profile tripods with high-frequency ADCPs co-located with two of the large tripods were selected for this goal. This report describes the data obtained during the field program, the instruments and data-processing procedures used, and the archive that contains the data sets that have passed our quality-assurance procedures.

Auxiliary feedwater system risk-based inspection guide for the Palo Verde Nuclear Power Plant

International Nuclear Information System (INIS)

Bumgardner, J.D.; Moffitt, N.E.; Gore, B.F.; Vo, T.V.; Sloan, J.A.

1993-02-01

In a study sponsored by the US Nuclear Regulatory Commission (NRC), Pacific Northwest Laboratory has developed and applied a methodology for deriving plant-specific risk-based inspection guidance for the auxiliary feedwater (AFW) system at pressurized water reactors that have not undergone probabilistic risk assessment (PRA). This methodology uses existing PRA results and plant operating experience information. Existing PRA-based inspection guidance information recently developed for the NRC for various plants was used to identify generic component failure modes. This information was then combined with plant-specific and industry-wide component information and failure data to identify failure modes and failure mechanisms for the AFW system at the selected plants. Palo Verde was selected as one of a series of plants for study. The product of this effort is a prioritized listing of AFW failures which have occurred at the plant and at other PWRs. This listing is intended for use by NRC inspectors in the preparation of inspection plans addressing AFW risk-important components at the Palo Verde plants

Remote handling and robotic inspections of Palo Verde reactor vessel internals

International Nuclear Information System (INIS)

Ryder, W.

1998-01-01

Remote visual examinations and handling evolutions in high radiation field environments have required the use of radiation tolerant video systems. These systems involve significant expense and potentially require large envelope deployment structures. Recent events at Palo Verde including Upper Guide Structure damage and Reactor Vessel In-Service Inspections have provided opportunities for research, design and utilization of alternative approaches. Most significant of these, utilization of CCD modules with high magnification capabilities, have produced higher quality viewing, reduced maintenance expenditures, and rapid deployment intervals. (orig.) [de

Tube structural integrity evaluation of Palo Verde Unit 1 steam generators for axial upper-bundle cracking

International Nuclear Information System (INIS)

Woodman, B.W.; Begley, J.A.; Brown, S.D.; Sweeney, K.; Radspinner, M.; Melton, M.

1995-01-01

The analysis of the issue of upper bundle axial ODSCC as it apples to steam generator tube structural integrity in Unit 1 at the Palo Verde Nuclear generating Station is presented in this study. Based on past inspection results for Units 2 and 3 at Palo Verde, the detection of secondary side stress corrosion cracks in the upper bundle region of Unit 1 may occur at some future date. The following discussion provides a description and analysis of the probability of axial ODSCC in Unit 1 leading to the exceedance of Regulatory Guide 1.121 structural limits. The probabilities of structural limit exceedance are estimated as function of run time using a conservative approach. The chosen approach models the historical development of cracks, crack growth, detection of cracks and subsequent removal from service and the initiation and growth of new cracks during a given cycle of operation. Past performance of all Palo Verde Units as well as the historical performance of other steam generators was considered in the development of cracking statistics for application to Unit 1. Data in the literature and Unit 2 pulled tube examination results were used to construct probability of detection curves for the detection of axial IGSCC/IGA using an MRPC (multi-frequency rotating panake coil) eddy current probe. Crack growth rates were estimated from Unit 2 eddy current inspection data combined with pulled tube examination results and data in the literature. A Monte-Carlo probabilistic model is developed to provide an overall assessment of the risk of Regulatory Guide exceedance during plant operation

Palo Verde Unit 3 BMI nozzle modification

International Nuclear Information System (INIS)

Waskey, D.

2015-01-01

The 61 BMI (Bottom Mount Instrumentation) nozzles of the unit 3 of the Palo Verde plant have been examined through ASME Code Case N722. The nozzle 3 was the only one with leakage noted. The ultrasound testing results are characteristic of PWSCC (Primary Water Stress Corrosion Cracking). The initiation likely occurred at a weld defect which was exposed to the primary water environment resulting in PWSCC. All other nozzles (60) showed no unacceptable indications. Concerning nozzle 3 one crack in J-groove weld connected large defect to primary water. An environmental model has been used to simulate and optimize the repair. The AREVA crew was on site 18 days after contract award and the job was completed in 12 days, 30 hours ahead of baseline schedule. This series of slides describes the examination of the BMI nozzles, the repair steps, and alternative design concepts

Toetame lasteaedu ja lasteaia õpetajaid / Urve Palo

Index Scriptorium Estoniae

Palo, Urve, 1972-

2007-01-01

Ilmunud ka: Põhjarannik, 7. sept. 2007, lk. 2; Severnoje Poberezhje, 7. sept. 2007, lk. 2; Meie Maa, 7. sept. 2007, lk. 2; Kuulutaja, 7. sept. 2007, lk. 4; Koit, 8. sept. 2007, lk. 5; Võrumaa Teataja, 8. sept. 2007, lk. 2; Vooremaa, 8. sept. 2007, lk. 2; Sakala, 11. sept. 2007, lk. 2; Nädaline, 11. sept. 2007, lk. 2; Pärnu Postimees, 12. sept. 2007, lk. 15; Valgamaalane, 13. sept. 2007, lk. 2; Hiiu Leht, 18. sept. 2007, lk. 2; Sõnumitooja, 19. sept. 2007, lk. 2; Maaleht, 20. sept. 2007, lk. 8; Nädalaleht, 7. sept. 2007, lk. 2. Rahvastikuminister Urve Palo kinnitusel eraldab uus valitsus rohkem kui kunagi varem raha uute lasteaedade ehituseks ja vanade renoveerimiseks, oluliseks sammuks on lasteaiaõpetajate palga tõstmine, tähelepanu all on piirkondlike erinevuste vähendamine palgatasemetes ning lasteaiaõpetajate palga viimine põhikooliõpetajate alampalga tasemele

Winter sound-level characterization of the Deaf Smith County location in the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

1984-03-01

A description of sound levels and sound sources in the Deaf Smith County location in the Palo Duro Basin during a period representative of the winter season is presented. Data were collected during the period February 26 through March 1, 1983. 4 references, 1 figure, 3 tables

Investigation of the suspected presence of solid hydrocarbon in bedded salt samples from the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

1985-10-01

This report contains laboratory test results for two bedded salt samples from the Grabbe No. 1 (PD-2) Well of the Palo Duro Basin, Texas. This study was commissioned to determine whether or not solid hydrocarbons exist in bedded salt samples in the Palo Duro Basin. Laboratory investigations include electron microprobe examinations on polished thin sections and optical examinations and chemical tests on insoluble residues of the salt samples. No direct evidence was found that identifiable solid hydrocarbons are present in either sample of the bedded salt core. The total carbon content of the two salt samples was measured yielding 0.016 and 0.022 weight percent carbon. Detailed microscopic analyses showed that the carbon in the samples was associated with calcite, clays, and the epoxy resin used in sample preparation

LoWMob: Intra-PAN Mobility Support Schemes for 6LoWPAN.

Science.gov (United States)

Bag, Gargi; Raza, Muhammad Taqi; Kim, Ki-Hyung; Yoo, Seung-Wha

2009-01-01

Mobility in 6LoWPAN (IPv6 over Low Power Personal Area Networks) is being utilized in realizing many applications where sensor nodes, while moving, sense and transmit the gathered data to a monitoring server. By employing IEEE802.15.4 as a baseline for the link layer technology, 6LoWPAN implies low data rate and low power consumption with periodic sleep and wakeups for sensor nodes, without requiring them to incorporate complex hardware. Also enabling sensor nodes with IPv6 ensures that the sensor data can be accessed anytime and anywhere from the world. Several existing mobility-related schemes like HMIPv6, MIPv6, HAWAII, and Cellular IP require active participation of mobile nodes in the mobility signaling, thus leading to the mobility-related changes in the protocol stack of mobile nodes. In this paper, we present LoWMob, which is a network-based mobility scheme for mobile 6LoWPAN nodes in which the mobility of 6LoWPAN nodes is handled at the network-side. LoWMob ensures multi-hop communication between gateways and mobile nodes with the help of the static nodes within a 6LoWPAN. In order to reduce the signaling overhead of static nodes for supporting mobile nodes, LoWMob proposes a mobility support packet format at the adaptation layer of 6LoWPAN. Also we present a distributed version of LoWMob, named as DLoWMob (or Distributed LoWMob), which employs Mobility Support Points (MSPs) to distribute the traffic concentration at the gateways and to optimize the multi-hop routing path between source and destination nodes in a 6LoWPAN. Moreover, we have also discussed the security considerations for our proposed mobility schemes. The performance of our proposed schemes is evaluated in terms of mobility signaling costs, end-to-end delay, and packet success ratio.

LoWMob: Intra-PAN Mobility Support Schemes for 6LoWPAN

Directory of Open Access Journals (Sweden)

Seung-Wha Yoo

2009-07-01

Full Text Available Mobility in 6LoWPAN (IPv6 over Low Power Personal Area Networks is being utilized in realizing many applications where sensor nodes, while moving, sense and transmit the gathered data to a monitoring server. By employing IEEE802.15.4 as a baseline for the link layer technology, 6LoWPAN implies low data rate and low power consumption with periodic sleep and wakeups for sensor nodes, without requiring them to incorporate complex hardware. Also enabling sensor nodes with IPv6 ensures that the sensor data can be accessed anytime and anywhere from the world. Several existing mobility-related schemes like HMIPv6, MIPv6, HAWAII, and Cellular IP require active participation of mobile nodes in the mobility signaling, thus leading to the mobility-related changes in the protocol stack of mobile nodes. In this paper, we present LoWMob, which is a network-based mobility scheme for mobile 6LoWPAN nodes in which the mobility of 6LoWPAN nodes is handled at the network-side. LoWMob ensures multi-hop communication between gateways and mobile nodes with the help of the static nodes within a 6LoWPAN. In order to reduce the signaling overhead of static nodes for supporting mobile nodes, LoWMob proposes a mobility support packet format at the adaptation layer of 6LoWPAN. Also we present a distributed version of LoWMob, named as DLoWMob (or Distributed LoWMob, which employs Mobility Support Points (MSPs to distribute the traffic concentration at the gateways and to optimize the multi-hop routing path between source and destination nodes in a 6LoWPAN. Moreover, we have also discussed the security considerations for our proposed mobility schemes. The performance of our proposed schemes is evaluated in terms of mobility signaling costs, end-to-end delay, and packet success ratio.

Agrochemical characterization of vermicomposts produced from residues of Palo Santo (Bursera graveolens) essential oil extraction.

Science.gov (United States)

Carrión-Paladines, Vinicio; Fries, Andreas; Gómez-Muñoz, Beatriz; García-Ruiz, Roberto

2016-12-01

Fruits of Palo Santo (Bursera graveolens) are used for essential oil extraction. The extraction process is very efficient, because up to 3% of the fresh fruits can be transformed into essential oil; however, a considerable amount of waste is concurrently produced (>97% of the fresh biomass). Recent developments in Ecuadorian policies to foster environmentally friendly agroforestry and industrial practices have led to widespread interest in reusing the waste. This study evaluated the application of four vermicomposts (VMs), which are produced from the waste of the Palo Santo fruit distillation in combination with other raw materials (kitchen leftovers, pig manure, goat manure, and King Grass), for agrochemical use and for carbon (C) and nitrogen (N) decomposition in two soils with different textures. The results showed that the vermicompost mixtures (VMM) were valuable for agricultural utilisation, because total N (min. 2.63%) was relatively high and the C/N ratio (max. 13.3), as well as the lignin (max. 3.8%) and polyphenol (max. 1.6%) contents were low. In addition, N availability increased for both soil types after the application of the VMM. In contrast, N became immobile during decomposition if the VM of the pure waste was added. This likely occurred because of the relatively low total N (1.16%) content and high C/N ratio (35.0). However, the comparatively low C decomposition of this VM type makes its application highly recommendable as a strategy to increase the levels of organic matter and C, as well as for soil reclamation. Overall, these results suggest that the residues of the Palo Santo essential oil extraction are a potential source for vermicompost production and sustainable agriculture. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Palo Verde story: a foundation for future multi-station nuclear power plants

International Nuclear Information System (INIS)

Brunt, Jr.E.E.Van; Ferguson, C.

1987-01-01

In 1973, the design and planning for the Palo Verde Nuclear Generating Station Was started featuring three 3800 MWt Combustion Engineering Standard System 80 Nuclear Steam Supply Systems. Arizona Public Service Company (APS) was the Project Manager and Operating Agent and Bechtel Power Corporation the architect/engineer and constructor. The Palo Verde units are located in a desert environment some 50 miles west of Phoenix, Arizona. It is a 'dry site' in that there are no liquid discharges from the site. The cooling tower makeup water sewage is waste effluent from the City of Phoenix treated at an on site reclamation facility. The effluent has had primary and secondary treatment at the Phoenix plant prior to delivery to PVNGS. The units are physically separate from each other but are of identical design. There are no shared safety systems between the units. Unit 1 and Unit 2 are both in commercial operation (January, 1986 and September, 1986 respectively). Unit 3 is scheduled to load fuel late in the first quarter of 1987. This paper presents some of the engineering and management practices used during design, construction, and startup and operational experiences and other unique features of this multi-unit nuclear station. The site arrangement is shown in Figure 1

The Interactive Dimension of Communication: The Pragmatics of the Palo Alto Group

OpenAIRE

Codruţa Porcar; Cristian Hainic

2011-01-01

Our paper proposes to analyze from a semiotic perspective the process of communication as conceived within the Palo Alto Group. We will firstly show that, as a result of the Group's critiques and revisions of the linear or mechanistic theories of communication, new perspectives are brought about for the essential axes of transformation within communication: we do not communicate as from a distinct atom to another, through an isolated channel, but through parts which are equal to the whole, th...

Lo público, lo estatal y la democracia

Directory of Open Access Journals (Sweden)

Osvaldo Iazzetta

2008-09-01

Full Text Available La calidad de lo público no resulta indistinta para juzgar la calidad de una democracia, pues la vitalidad y diversidad de aquel espacio delimita sus posibilidades de despliegue y profundización. Sin embargo, lo público se nutre tanto de la energía proveniente de la asociatividad, participación, deliberación y auto-organización de la sociedad civil, como de la universalidad que el Estado debe asegurar para tornar efectiva la promesa democrática. En esa zona confluyen por consiguiente, energías provenientes de lo público-social como de lo público-estatal. Sin desconocer esa complejidad, en este trabajo nos centraremos en este último aspecto, entendiendo esta elección como una vía de entrada –entre otras posibles– para reflexionar sobre algunas tareas democráticas pendientes.

Response to IPE and IPEEE results at Palo Verde NGS

International Nuclear Information System (INIS)

Lindquist, R.C.

1992-01-01

Insights gained from the internal events probabilistic risk assessment (PRA) and from the pilot plant demonstration of the fire-induced vulnerability evaluation (FIVE) have been used to initiate corrective actions in the form of administrative controls, compensatory measures, and plant modifications to reduce the risks associated with significant core-damage sequences. Palo Verde was a pilot demonstration plant for the FIVE methodology developed by the Electrical Power Research Institute and sponsored by the Nuclear Utility Management and Resources Council. Several findings emerged from the application of FIVE and have been acted upon to reduce the impact of fire in several compartments of the plant

Search for neutrino oscillations at the palo verde nuclear reactors

Science.gov (United States)

Boehm; Busenitz; Cook; Gratta; Henrikson; Kornis; Lawrence; Lee; McKinny; Miller; Novikov; Piepke; Ritchie; Tracy; Vogel; Wang; Wolf

2000-04-24

We report on the initial results from a measurement of the antineutrino flux and spectrum at a distance of about 800 m from the three reactors of the Palo Verde Nuclear Generating Station using a segmented gadolinium-loaded scintillation detector. We find that the antineutrino flux agrees with that predicted in the absence of oscillations excluding at 90% C.L. nu;(e)-nu;(x) oscillations with Deltam(2)>1.12x10(-3) eV(2) for maximal mixing and sin (2)2straight theta>0.21 for large Deltam(2). Our results support the conclusion that the atmospheric neutrino oscillations observed by Super-Kamiokande do not involve nu(e).

DOE Zero Energy Ready Home Case Study: Palo Duro Homes, Albuquerque, New Mexico

Energy Technology Data Exchange (ETDEWEB)

none,

2013-09-01

Palo Duro uses advanced framing techniques like 2x6 24-inch on-center framing, open headers above windows on non-load-bearing walls, 2-stud corners, ladder blocking where walls intersect, and single top and bottom plates. These techniques reduce the amount of lumber in the wall, allowing more room for insulation and reducing costs and installation time. The builder garnered a 2013 Housing Innovation Award in the production builder category.

Dissolution of the Upper Seven Rivers and Salado salt in the interior Palo Duro Basin, Texas: Revision: Topical report

International Nuclear Information System (INIS)

DeConto, R.T.; Murphy, P.J.

1987-09-01

The Upper Seven Rivers and Salado Formations contain the uppermost salts within the interior Palo Duro Basin, Stratigraphic and structural evidence based on geophysical well logs indicate that both dissolution and facies change have influenced the thickness of these uppermost salts. The magnitude of vertical salt loss due to dissolution is interminable at this time because original salt thickness is unknown. Gradual thinning of the Upper Seven Rivers Formation is recognized from south to north across the Palo Duro Basin. Anhydrites within the formation pinch out toward the basin margins, indicating that section loss is in part depositionally controlled. Additionally, informal subdivision of the Upper Seven Rivers Formation suggests that salt dissolution has occurred in the uppermost salt. A northeast-trending zone of thin Upper Seven Rivers Formation in portions of Deaf Smith, Randall, Castro, and Parmer Counties is possibly related to Tertiary dissolution. In New Mexico, local thinning of the Upper Seven Rivers Formation may be associated with faulting. Triassic erosion on uplifted fault blocks has affected the Upper Permian section. The Salado salt margin is located within the interior Palo Duro Basin. Geophysical well logs and core evidence indicate that the salt margin has migrated basinward as a result of dissolution. Permian dissolution probably contributed to some salt loss. 106 refs., 31 figs., 2 tabs

El sexo de las metáforas

Directory of Open Access Journals (Sweden)

Pérez Sedeño, Eulalia

2011-02-01

Full Text Available The hypothesis that states metaphors are structurally determinant in our social relations, routines, and experience has been accepted broadly in the last decades. Moreover, metaphors are to be found in many different levels of scientific practices, and have a diverse set of functions in science. Therefore, they impregnate all scientific enterprise. In this work we examine selected gender metaphors used in biology. We show metaphors are effective precisely because its effectiveness depends on shared social conventions, kinship relations and, authority that, by convention, is given to those that use them.

La tesis de que las metáforas estructuran gran parte de nuestras relaciones sociales y nuestra experiencia cotidiana ha sido ampliamente aceptada en las últimas décadas. En la ciencia, además, aparecen en muchos niveles y desempeñan diversas funciones, impregnando todo el quehacer científico. En este trabajo se examinan algunas metáforas de género usadas en biología. Se muestra que las metáforas eficaces lo son porque su efectividad depende de las convenciones sociales compartidas, los parecidos de familia ya vigentes y de la autoridad que, por convención, se otorga a quienes las usan.

75 FR 53985 - Arizona Public Service Company, et al., Palo Verde Nuclear Generating Station, Unit 3; Temporary...

Science.gov (United States)

2010-09-02

... NUCLEAR REGULATORY COMMISSION [Docket No. STN 50-530; NRC-2010-0281] Arizona Public Service Company, et al., Palo Verde Nuclear Generating Station, Unit 3; Temporary Exemption 1.0 Background Arizona Public Service Company (APS, the licensee) is the holder of Facility Operating License No. NPF-74, which...

Agrochemical characterization of vermicomposts produced from residues of Palo Santo (Bursera graveolens) essential oil extraction

DEFF Research Database (Denmark)

Carrión-Paladines, Vinicio; Fries, Andreas; Gomez Muñoz, Beatriz

2016-01-01

Fruits of Palo Santo (Bursera graveolens) are used for essential oil extraction. The extraction process is very efficient, because up to 3% of the fresh fruits can be transformed into essential oil; however, a considerable amount of waste is concurrently produced (>97% of the fresh biomass). Rece...

DE LO INERME A LO VIVO, DE LO VIRTUAL A LO VIRTUOSO: LAS REDES COMUNICACIONALES ENTRE CIENTÍFICOS

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Juan José Plata Cavides

2002-08-01

Full Text Available El tema que quiero abordar es la comunicación entre científicos, algo que es esencial al ethos del investigador, pero que hoy por hoy tiende a suplirse por quimeras técnicas y mediáticas. Quiero poner a consideración de hecho evidente a partir de la experiencia vivida que señala como solamente a partir de la participación en redes comunicacionales vivas es que emerge la posibilidad de generar conocimiento nuevo en cualquier dominio Las reglas del juego de con validación de conocimientos excluyen argumentos tales como la autoridad o el poder o similares, sin dejar de lado las múltiples evidencias sobre las dificultades y errores que emergen en los procesos comunicacionales. En una pregunta ¿Cuál es nuestra capacidad para comunicarnos y comunicar? Tres son los retos que quiero formular: El reto de pasar de la VISIÓN de los objetos a La COMPRENSIÓN de los procesos (contextos de sentido El reto de pasar de la MIRADA a las partes a la INTERACCIÓN entre las partes y las características emergentes del sistema de relaciones. (recursividad, auto-organización El reto de pasar de la CONTEMPLACIÓN de la palabra y la gramática a la PRAXIS de las redes conversacionales vivas. En suma el reto que propongo es el reto de pasar de lo inerte a lo vivo, de lo virtual a lo virtuoso, de la red conversacional muerta a la red conversacional viva, de la robótica y el cyborg a lo distintivamente humano. Pues, el conocimiento se juega como estrategia adaptativa al entorno, se juega localmente, y en su vivencia es más que el simple hecho de almacenar o hacer circular información.

Surface hydrologic characteristics of proposed repository locations in the Palo Duro Basin of the Texas Panhandle

International Nuclear Information System (INIS)

1985-04-01

This report provides a description of the surface hydrology in the two proposed locations of a high-level waste repository within the Palo Duro Basin of the Texas Panhandle. Included for consideration are the topography; the major drainage systems - Palo Duro, Tierra Blanca, and Tule Creeks, and Prairie Dog Town Fork of the Red River; and the most prominent impoundments, the playa lakes. The magnitude and frequency of precipitation throughout the region are discussed, and rainfall depth-duration-area data for the 100-year, 500-year, and probable maximum storms are presented. Soil properties are also described, with specific reference to the infiltration and runoff processes and the contribution of these processes to Ogallala aquifer recharge. A summary discussion of the local streams includes information on historical streamflow, a brief description of flooding, and results of a study of floodplains for the 100-year, 500-year, and probable maximum storms. The report concludes with a characterization of the water quality of these streams and an explanation of the local geologic influences on stream-water chemistry. 25 figures, 20 tables

Metáforas sobre el exilio en "Dios nos quiere contentos" de Griselda Gambarro.

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Ariadna Castellarnau

2010-01-01

Full Text Available El presente artículo analiza la novela Dios no nos quiere contentos, de la escritora argentina Griselda Gambaro, desde la perspectiva de la literatura de exilio. Esto significa trazar una lectura de la obra no tanto desde lo vivencial (como trasunto literario de la propia experiencia de la autora como desterrada durante el período de la última dictadura militar argentina como desde lo universal: analizando la experiencia del exilio como un hecho en abstracto, aplicable a cualquier contexto nacional e histórico, a través de las metáforas sobre las que trabaja Gambaro.

Technical basis for high-level waste repository land control requirements for Palo Duro Basin, Paradox Basin, and Richton Dome

International Nuclear Information System (INIS)

Chen, C.P.; Raines, G.E.

1987-02-01

Three sites, the Palo Duro Basin in Texas, the Paradox Basin in Utah, and the Richton Dome in Mississippi, are being investigated by the US Department of Energy for high-level radioactive-waste disposal in mined, deep geologic repositories in salt. This report delineates the use of regulatory, engineering, and performance assessment information to establish the technical basis for controlled area requirements. Based on the size of the controlled area determined, plus that of the geologic repository operations area, recommendations of possible land control or ownership area requirements for each locale are provided. On a technical basis, the following minimum land control or ownership requirements are recommended, assuming repository operations area of 2240 ac (907 ha), or 3.5 mi 2 (9.1 km 2 ): Palo Duro Basin - 4060 ac (1643 ha), or 6.3 mi 2 (16.4 km 2 ); Paradox Basin - 4060 ac (1643 ha), or 6.3 mi 2 (16.4 km 2 ); and Richton Dome - 5000 ac (2024 ha), or 7.8 mi 2 (20.2 km 2 ). Of the factors used to determine the technically based recommendations, one was found to dominate each locale. For the Palo Duro and Paradox Basins, the dominant factor was the need to limit potential radionuclide release by ground-water flow to the accessible environment. For the Richton Dome, the dominant factor was the need to limit the potential effects of solution mining on dome and repository integrity

Lo irreductible social y lo irreductible psíquico

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Vincent Gaulejac, de

2017-06-01

Full Text Available Con base en la reconstrucción de las polaridades explicativas -lo irreductible social y lo irreductible psíquico-que atraviesan a las ciencias sociales, este texto propone trascender los modelos antagónicos y excluyentes. El objetivo es instaurar en el centro de la reflexión la idea de la dialktica existencial que restituye al sujeto tanto el contexto socio-histórico en el cual está localizado como el deseo y la singularidad que lo constituyen en productor de la afirmación de su individualidad y su historicidad.

Interpretation of seismic reflection data, Central Palo Duro Basin: Technical report

International Nuclear Information System (INIS)

1986-11-01

Seismic reflection data from the Central Palo Duro Basin, Texas, were studied to identify and characterize geologic structure, potential hydrocarbon traps, and anomalies suggesting adverse features such as salt dissolution or diapirism. The data included seismic reflection data, geologic and geophysical data controlled by Stone and Webster Engineering Corporation, and data from the literature. These data comprised approximately 590 line-mi of seismic profiles over approximately 4000 mi 2 , plus well logs from 308 wells. The study addressed the section from shallow reflectors down to basement. Structural contour maps were prepared for the Upper San Andres, Near Top of Glorieta, Wolfcamp, and Precambrian horizons. Isopach maps were prepared for intervals between the Upper and Lower San Andres and between the Upper San Andres and the Wolfcamp. Interpretation indicates southeasterly dips in the northwest part of the mapped area and southwesterly dips in the southwest part. Geologic structures show a generally northwest alignment. Faults at the Precambrian level and geologic structures show a generally northwest alignment. Faulting in the area is largely limited to the Precambrian, but interpretation is uncertain. Evidence of post-Wolfcampian faulting is not recognized. Seismic data delineating the San Andres section indicate a stable section throughout the area. Anomalous reflection events possibly associated with subsurface salt dissolution were seen at the 800- to 1200-ft level in Swisher County. Other anomalies include an overthickened zone northwest of Westway and carbonate buildup in the Wolfcamp and Pennsylvanian in Randall County. Mississippian to Middle Pennsylvanian diastrophism resulting in the Amarillo Uplift and Matador Arch is not manifested structurally in the central Palo Duro Basin. Subsidence or gentle uplift contributed to some structural deformation

Leer lo estético desde lo político

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Verónica Peñafiel

2013-06-01

Full Text Available En el Ecuador, y específicamente en la vida política del país, el teatro ha jugado un papel más importante del que se le ha reconocido. Pensar lo estético relacionado con lo político, puede ser una interesante clave de lectura para el teatro quiteño y, me arriesgo a afirmar, para el teatro a secas. Este análisis no se lo hará desde el teatro político, se pretende, más bien, analizar la dimensión política del mismo y de la relación entre teatro y política. Dicha dimensión política ha tomado diversas caras. Con los matices posibles, ha pasado de las salas a la calle, del costumbrismo a lo grotesco, de las compañías a los grupos. Comprender estos matices con la óptica de lo político puede dar pistas para articular una lógica estética del teatro quiteño

Lo público y lo privado en Educación

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J. Félix ANGULO RASCO

2016-01-01

Full Text Available El presente trabajo pretende delinear qué se entiende por escuela pública o, dicho de otra manera, qué hace pública a una escuela. Para ello, se apoya en tres ejes básicos: el sentido estructural, el sentido político y el sentido pedagógico. El sentido estructural pregunta por la pertenencia de la escuela. La pertenencia privada de un centro escolar lo inhabilita para ser un centro público. Lo privado en este caso estaría por encima de lo público y lo común. Por el contrario, la pertenencia pública no ha de asimilarse a la pertenencia estatal. Lo público ha de hacer referencia a lo común. El sentido político indica que una escuela pública sirve al bien común y, especialmente, a los más necesitados. La escuela pública en ese sentido es un espacio de encuentro de la sociedad y además el único espacio educativo para aquellos sectores que no tendrían otra posibilidad. Por último, el sentido pedagógico es el que, al fin y al cabo, da sentido pleno a la escuela pública, en cuanto que supone colmar el derecho de las generaciones y la ciudadanía a la cultura y al conocimiento.

¿Es posible combinar lo tradicional y lo moderno?

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Hugo Celso Felipe Mansilla

2001-01-01

Full Text Available En contra de las actuales tendencias posmodérnicas, el autor postula una simbiosis entre los elementos positivos de lo premoderno y los correspondientes de la modernidad. Cree posible rescatar las llamadas tradiciones razonable, y combinarlas con lo positivo de la modernidad. Estos factores positivos de la tradicionalidad serían la religión en cuanto fuente de sentido y consuelo, la monarquía y la aristocracia hereditarias como modelos institucionales que nos unen con la historia, y la concepción del arte y la literatura como una estética fundamentada en lo bello. Esfuerzos sincretistas similares constituyen gran parte de la historia universal.

Second status report on regional ground-water flow modeling for the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

1986-07-01

Regional ground-water flow within the principal geohydrologic units of the Palo Duro Basin is evaluated by developing a conceptual model of the flow regime and testing the model using a three-dimensional, finite-difference flow code. Sensitivity analyses (a limited parametric study) are conducted to define the system responses to changes in the conceptual model. Of particular interest are the impacts of salt permeability and potential climatic changes on the system response. The conceptual model is described in terms of its areal and vertical discretization, aquifer properties, fluid properties and hydrologic boundary conditions. The simulated ground-water flow fields are described with potentiometric surfaces, tables summarizing the areal and vertical volumetric flows through the principal units, and Darcy velocities within specified finite-difference blocks. The reported work is the second stage of an ongoing evaluation of the Palo Duro Basin as a potential repository for high-level radioactive wastes. The results and conclusions should thus be considered preliminary and subject to modification with the collection of additional data. However, the report does provide a useful basis for describing the sensitivity of the present conceptualization of ground-water flow to particular parameters and, to a lesser extent, the uncertainties in the present conceptualization. 28 refs., 44 figs., 13 tabs

Lo privado de lo público para jóvenes universitarios en Colombia

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Victoria Eugenia Pinilla Sepúlveda

2008-01-01

un afrontamiento manipulador. Lo público se caracteriza por una tensión constante, entre fuerzas instituidas en los ámbitos familiar, educativo y social, que imponen formas de comportamiento, normas y valores que conforman un orden establecido, y las posibilidades de cambio que se van fraguando y que generan movimiento frente a lo instituido. En medio de esta coexistencia de fuerzas que conviven y se contraponen, aparecen los jóvenes dando prioridad al "sí mismo", a lo subjetivo sobre lo colectivo, en una urgente búsqueda de autodeterminación como un reclamo directo por su reconocimiento en un ámbito de lo público que los relega a la periferia.

75 FR 15745 - Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

Science.gov (United States)

2010-03-30

...] Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3; Exemption 1.0 Background The Arizona Public Service Company (APS, the licensee) is the holder of Facility... Generating Station (PVNGS), Units 1, 2, and 3, respectively. The licenses provide, among other things, that...

Lo real y lo virtual en las redes electrónicas

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Francisco Ficarra

2015-01-01

Full Text Available Se ha considerado que la expansión de las redes electrónicas produciría una igualdad económica entre los seres humanos, sin embargo esto es solo una utopía. El autor comenta lo ocurrido en lo real y lo virtual desde los años 60. La posibilidad de alcanzar un equilibrio entre ofertas de nuevos servicios y necesidades auténticas de la sociedad es una tarea difícil, pero el esfuerzo vale la pena para no caer en una especie de miniserie civilizada.

Palo Verde nuclear generating station EASEplus SIMULATE model

International Nuclear Information System (INIS)

McDonald, W.F.; Reed, M.L.; Fauste, J.L.

1992-01-01

The Palo Verde on-site reactor engineers have an extremely powerful and accurate tool for quickly predicting the effects of reactor power maneuvers on core axial shape index (ASI) and xenon worth. They can analyze postulated future power maneuvers quickly and supply the reactor operators with valuable predictions without having to consult with the off-site nuclear analysis group. The tool developed by the nuclear analysis group was an advanced nodal code with a graphic user interface (GUI) driver for ease of use. The advanced nodal code used was the Studsvik of America SIMULATE-3 Version 2.20-DSI. This SIMULATE version was compiled for use on a personal computer (PC) with a Definicon Systems' 50-MHz coprocessor board. The GUI face used was Expert-EASE Systems' EASE+SIM3 Version 3.0 pre-/postprocessor. The system was installed on Compaq Deskpro 386/20e PCs located in the control room of each of the three units, in the reactor engineering office, in the nuclear analysis office, and in the control room of the training simulator

Preliminary simulation model to determine ground-water flow and ages within the Palo Duro Basin hydrogeologic province

International Nuclear Information System (INIS)

Atwood, H.; Picking, L.

1986-01-01

Ground-water flow through the Palo Duro and Tucumcari Basins is simulated by developing a hydrogeolgic profile and applying a cross-sectional, finite-element, numerical model to the profile. The profile is 350 miles long and 2 miles deep and extends from east-central New Mexico to the Texas-Oklahoma border. It is comprised of hydrogeologic units that are identified from geophysical well logs, sample logs, and core descriptions. A hydrogeologic unit as used in this profile is a physically continuous rock sequence with hydrologic properties that are relatively consistent throughout and distinct from surrounding units. The resulting hydrogeologic profile, with the exception of the Ogallala Formation and the Dockum Group, is discretized into a 6000-element mesh and a 22,000-element mesh. Permeability values assigned to hydrogeologic units were, in part, calculated from drill stem tests conducted throughout the Palo Duro Basin. Ground-water age and travel paths are determined by applying Darcy's equation to selected flow lines. The 170 million-year age determined from ground-water at points within the Wolfcamp Series compares favorably with the geochemical data for this region. An age of 188 million years is determined for the Pennsylvanian granite wash

Geostatistical analysis of potentiometric data in Wolfcamp aquifer of the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Harper, W.V.; Furr, J.M.

1986-04-01

This report details a geostatistical analysis of potentiometric data from the Wolfcamp aquifer in the Palo Duro Basin, Texas. Such an analysis is a part of an overall uncertainty analysis for a high-level waste repository in salt. Both an expected potentiometric surface and the associated standard error surface are produced. The Wolfcamp data are found to be well explained by a linear trend with a superimposed spherical semivariogram. A cross-validation of the analysis confirms this. In addition, the cross-validation provides a point-by-point check to test for possible anomalous data

Summer sound-level characterization of the Deaf Smith County and Swisher County locations in the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

1984-03-01

A description of sound levels and sound sources in the Deaf Smith County and Swisher County locations in the Palo Duro Basin during a period representative of the summer season is presented. Included are data collected during the period August 4 through 8, 1982, for both locations. 3 references, 2 figures, 3 tables

Comunidad de parásitos metazoarios de la charra Cichlasoma trimaculatum en la laguna de Tres Palos, Guerrero, México Metazoan parasite community in the three-spot cichlid Cichlasoma trimaculatum from Tres Palos Lagoon, Guerrero, Mexico

Directory of Open Access Journals (Sweden)

Juan Violante-González

2008-12-01

Full Text Available Entre abril de 2000 y noviembre de 2002 se examinó la composición de la comunidad de parásitos metazoarios de la charra, Cichlasoma trimaculatum a partir de muestras temporales. Fueron recuperadas 12 especies de parásitos (40 969 individuos de 231 hospederos examinados; 10 helmintos: Ascocotyle (Phagicola longa, Austrodiplostomum compactum, Cladocystis trifolium, Clinostomum complanatum, Crassicutis cichlasomae, Posthodiplostomum minimum, Pseudoacanthostomum panamense, Neoechinorhynchus golvani, Southwellina hispida y Contracaecum sp., y 2 crustáceos: Argulus sp. y Ergasilus sp. La comunidad se caracterizó por un número mayor de parásitos generalistas y pocos especialistas de cíclidos, además por ser pobre en especies. De las 5 especies comunes dentro de la comunidad, 4 presentaron variación temporal en su dinámica de infección a lo largo del tiempo, la cual fue asociada con cambios ambientales generados durante las temporadas de secas y lluvias. La variación en la dinámica de infección de las especies comunes fue capaz de generar cambios en la estructura, tanto en el nivel de componente como en el de infracomunidad; sin embargo, no se observó un patrón claro, lo que indica que la comunidad puede ser poco predecible, como se sugiere para otras comunidades de parásitos de peces dulceacuícolas.We analyzed metazoan parasite community composition in the three-spot cichlid Cichlasoma trimaculatum using seasonal samples taken between April 2000 and November 2002 from the Tres Palos Lagoon, Guerrero, Mexico. A total of 231 hosts were examined. Of the 12 parasite species recovered (40,969 individuals, 10 were helminths: Ascocotyle (Phagicola longa, Austrodiplostomum compactum, Cladocystis trifolium, Clinostomum complanatum, Crassicutis cichlasomae, Posthodiplostomum minimum, Pseudoacanthostomum panamense, Neoechinorhynchus golvani, Southwellina hispida, and Contracaecum sp. The remaining 2 were the crustaceans Argulus sp. and

Technical specifications, Palo Verde Nuclear Generating Station, Unit No. 2 (Docket No. 50-529). Appendix A to License No. NPF-51

International Nuclear Information System (INIS)

1986-04-01

Information is presented concerning the technical specifications for the Palo Verde-2 Reactor. Areas of interest discussed in this report include: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls. 19 figs., 62 tabs

Lo privado de lo público para jóvenes universitarios en Colombia

Directory of Open Access Journals (Sweden)

Victoria Eugenia Pinilla Sepúlveda

2008-10-01

Full Text Available La investigación busca comprender los significados que tienen “lo público” y las relaciones adulto-joven para un grupo de jóvenes universitarios en sus acciones cotidianas y a partir de las narrativas de sus experiencias. Es un estudio hermenéutico que analiza las narrativas en el contexto de la dialéctica de la comprensión y la explicación propuesta por Ricoeur. Aborda lo generacional, las relaciones adulto-joven y lo público, desde algunos aportes de la sociología y la teoría política como los de Mannheim, Martin Criado, Corsten, Arendt, Habermas y Fraser. Así mismo despliega la fundamentación teórica de la narrativa como opción que posibilita el acercamiento a los significados de un grupo de jóvenes universitarios. La categoría relaciones adulto-joven muestra, más que encuentros, desencuentros entre ambas generaciones, caracterizados por un control al que los jóvenes reaccionan con una subordinación pasiva, o con un afrontamiento manipulador. Lo público se caracteriza por una tensión constante, entre fuerzas instituidas en los ámbitos familiar, educativo y social, que imponen formas de comportamiento, normas y valores que conforman un orden establecido, y las posibilidades de cambio que se van fraguando y que generan movimiento frente a lo instituido. En medio de esta coexistencia de fuerzas que conviven y se contraponen, aparecen los jóvenes dando prioridad al “sí mismo”, a lo subjetivo sobre lo colectivo, en una urgente búsqueda de autodeterminación como un reclamo directo por su reconocimiento en un ámbito de lo público que los relega a la periferia.

MetHumi - Humidity Device for Mars MetNet Lander

Science.gov (United States)

Genzer, Maria; Polkko, Jouni; Harri, Ari-Matti; Schmidt, Walter; Leinonen, Jussi; Mäkinen, Teemu; Haukka, Harri

2010-05-01

MetNet Mars Mission focused for Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetHumi is the humidity sensor of MetNet Lander designed to work on Martian surface. It is based on Humicap® technology developed by Vaisala, Inc. MetHumi is a capacitive type of sensing device where an active polymer film changes capacitance as function of relative humidity. One MetHumi device package consists of one humidity transducer including three Humicap® sensor heads, an accurate temperature sensor head (Thermocap® by Vaisala, Inc.) and constant reference channels. MetHumi is very small, lightweighed and has low power consumption. It weighs only about 15 g without wires, and consumes 15 mW of power. MetHumi can make meaningful relative humidity measurements in range of 0 - 100%RH down to -70°C ambient temperature, but it survives even -135°C ambient temperature.

Met kerse op met -konstruksies 1 : 'n Verwysingspuntperspektief ...

African Journals Online (AJOL)

Met kerse op met-konstruksies1: 'n Verwysingspuntperspektief. Johanna Messerschmidt, Luna Bergh. Abstract. This article analyses the usage of the Afrikaans preposition met ('with'). The analysis is done within the framework of Cognitive Linguistics and more specifically within the model proposed by Langacker (1993) ...

Lo que uno pretende que sea

OpenAIRE

Da Pieve, Enzo

2017-01-01

Si bien la escritura es, de manera teórica, una manifestación de la actividad lingüística humana que posee ciertos rasgos de intencionalidad y contextualidad de lo verbal, es necesario obstinarse en una búsqueda más profunda de la importancia de la escritura. Es fundamental hacer un análisis minucioso, tanto de lo formal como de lo emocional, lo contextual, lo social, lo artístico. La escritura es un mundo por descubrir. Centro de Investigación en Lectura y Escritura (CILE)

LO íntimo, lo doméstico y lo público: representaciones sociales y estilos de vida en la España ilustrada

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Mónica BOLUFER PERUGA

2009-12-01

Full Text Available RESUMEN: A partir de los textos autobiográficos, correspondencia y otros escritos de diversos personajes vinculados al reformismo ilustrado en la España del siglo xviii, este trabajo estudia los modos en que en sus representaciones de la sociedad y sus imágenes de sí mismos se articulaban los ámbitos de lo íntimo, lo doméstico y lo público, poniendo de relieve las diferencias que este engarce presentaba para hombres y mujeres, tanto en lo social como en lo personal, así como la significativa evolución experimentada a lo largo de los últimos decenios del siglo xvín y en los primeros años del xix.ABSTRACT: Based on autobiographical writings, correspondence and other works of men and women linked to enlightened reformism in eighteenth-century Spain, this paper studies how they played with the notions of intimacy, domesticity and public life when representing models of social organization and building self images. Differences between men and women experiences and languages are underlined, as well as changes during the last decades of the eighteenth century and the beginning of the nineteenth century.

DDE in sediments of the Palos Verdes shelf, California: In situ transformation rates and geochemical fate

Science.gov (United States)

Eganhouse, R.P.; Pontolillo, J.

2008-01-01

From 1947 to 1971 the world's largest manufacturer of DDT discharged process wastes into the sewers of Los Angeles County. Roughly 870-1450 t of DDT were released to the ocean off Palos Verdes, CA, a portion of which (???100 t) resides in sediments on the continental shelf and slope. The most abundant DDT compound in the sediments, p,p???-DDE, is degrading by reductive dechlorination, butthe rate of transformation and factors controlling it are not well understood. In order to estimate in situ transformation rates and predict the long-term fate of p,p???-DDE, box cores were collected in 1992 and 2003 from a single location on the Palos Verdes Shelf and analyzed for 8 DDT compounds and 84 polychlorinated biphenyl (PCB) congeners. The PCBs show no evidence of dechlorination, and inventories did not change between 1992 and 2003. By contrast, the inventory of p,p???-DDE decreased by 43%, whereas that of p,p???-DDMU, the putative reductive dechlorination product increased by 34%. The first-order transformation rate for p,p???-DDE at the study site is 0.051 ?? 0.006 yr-1. A multistep reaction model suggests that inventories of p,p???-DDE and p,p???-DDMU will continue to decline, whereas that of p,p???-DDNU will reach a maximum around 2014.

MetBaro - Pressure Device for Mars MetNet Lander

Science.gov (United States)

Haukka, Harri; Polkko, Jouni; Harri, Ari-Matti; Schmidt, Walter; Leinonen, Jussi; Genzer, Maria; Mäkinen, Teemu

2010-05-01

MetNet Mars Mission focused for Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetBaro is the pressure sensor of MetNet Lander designed to work on Martian surface. It is based on Barocap® technology developed by Vaisala, Inc. MetBaro is a capacitive type of sensing device where capasitor plates are moved by ambient pressure. MetBaro device consists of two pressure transducers including a total of 4 Barocap® sensor heads of high-stability and high-resolution types. The long-term stability of MetBaro is in order of 20…50 µBar and resolution a few µBar. MetBaro is small, lightweighed and has low power consumption. It weighs about 50g without wires and controlling FPGA, and consumes 15 mW of power. A similar device has successfully flown in Phoenix mission, where it performed months of measurements on Martian ground. Another device is also part of the Mars Science Laboratory REMS instrument (to be launched in 2011).

Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in south San Francisco Bay, California: 2014

Science.gov (United States)

Cain, Daniel J.; Thompson, Janet K.; Crauder, Jeff; Parcheso, Francis; Stewart, Robin; Kleckner, Amy E.; Dyke, Jessica; Hornberger, Michelle I.; Luoma, Samuel N.

2015-01-01

Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer (km) south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in South San Francisco Bay, Calif. This report includes the data collected by U.S. Geological Survey (USGS) scientists for the period January 2014 to December 2014. These append to long-term datasets extending back to 1974, and serve as the basis for the City of Palo Alto’s Near-Field Receiving Water Monitoring Program, initiated in 1994. 

Fluid inclusion brine compositions from Palo Duro Basin salt sites

International Nuclear Information System (INIS)

Moody, J.B.

1987-01-01

The fluid inclusion analyses were done on salt samples from Lower San Andres Cycle 4 and 5. The stable isotope composition of the fluid inclusion brines was measured on duplicate samples taken from the same fluid inclusion brine for correlation of geochemical content with the stable isotopic content. The analyzed Palo Duro Basin salt fluid inclusions are predominantly one phase, i.e., the presence of a fluid only. However, many of the larger fluid inclusions do have a small vapor bubble. This liquid/vapor ratio is so high in these vapor-containing fluid inclusions that their behavior in a thermal gradient would be almost identical to that of all liquid inclusions. Closely associated with the fluid inclusions are cryptomelane where some fibers penetrate into halite host crystal. The fluid inclusions have a wide variability in content for those components that were analyzed, even within the same salt type. The fluid inclusion brines are also acidic, ranging from 3 to 6 as measured with pH test papers

MetBaro - Pressure Instrument for Mars MetNet Lander

Science.gov (United States)

Polkko, J.; Haukka, H.; Harri, A.-M.; Schmidt, W.; Leinonen, J.; Mäkinen, T.

2009-04-01

THE METNET MISSION FOCUSED ON THE Martian atmospheric science is based on a new semihard landing vehicle called the MetNet Lander (MNL). The MNL will have a versatile science payload focused on the atmospheric science of Mars. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. MetBaro is the pressure instrument of MetNet Lander designed to work on Martian surface. It is based on Barocap® technology developed by Vaisala, Inc. MetBaro is a capacitic type of sensing device where capasitor plates are moved by ambient pressure. MetBaro device consists of two pressure transducers including a total of 6 Barocap® sensor heads of high-stability and high-resolution types. The long-term stability of MetBaro is in order of 20…50 µBar and resolution a few µBar. MetBaro is small, lightweighed and has low power consumption. It weighs about 50g without wires and controlling FPGA, and consumes 15 mW of power. A similar device has successfully flown in Phoenix mission, where it performed months of measurements on Martian ground. Another device is also part of the Mars Science Laboratory REMS instrument (to be launched in 2011).

Exponential-time constitutive law for Palo Duro Unit 4 Salt from the J. Friemel No. 1 Well

International Nuclear Information System (INIS)

Senseny, P.E.; Pfeifle, T.W.; Mellegard, K.D.

1986-07-01

Values for the nine parameters in the exponential-time constitutive law are presented for Palo Duro Unit 4 salt. The values given for the thermal expansion and two elastic parameters are taken from previous laboratory studies. The six remaining constitutive parameters are evaluated by analyzing data from 12 triaxial compression creep tests. The specimens tested in this study are from the J. Friemel No. 1 well in Deaf County, Texas. 15 refs., 15 figs., 4 tabs

Differences in MetS marker prevalence between black African and ...

African Journals Online (AJOL)

Multiple linear regression analysis, independent of covariates, showed that the albumin:creatinine ratio is explained only by glucose in Africans. Conclusion: African women, as a group, present with few MetS risk factors, and glucose is associated with renal function risk in Africans. Keywords: MetS, metabolic syndrome, ...

Organic geochemistry of deep ground waters from the Palo Duro Basin, Texas: implications for radionuclide complexation, ground-water origin, and petroleum exploration

International Nuclear Information System (INIS)

Means, J.L.; Hubbard, N.J.

1985-05-01

This report describes the organic geochemistry of 11 ground-water samples from the Palo Duro Basin, Texas and discusses the implications of their organic geochemical compositions in terms of radionuclide complexation, ground-water origin, and the petroleum potential of two candidate repository sites in Deaf Smith and Swisher Counties. Short-chain aliphatic acid anions are the principal organic constituents present. Stability constant data and simple chemical equilibria calculations suggest that short-chain aliphatic acids are relatively weak complexing agents. The extent of complexation of a typical actinide by selected inorganic ligands present in these brines is expected to far outweigh actinide complexation by the aliphatic acid anions. Various lines of evidence suggest that some portion of the bromide concentrations in the brines is derived from the same source as the short-chain aliphatic acid anions. When the postulated organic components are subtracted from total bromide concentrations, the origins of the Palo Duro brines, based on chloride versus bromide relationships, appear largely consistent with origins based on isotopic evidence. The short-chain aliphatic acid anion content of the Palo Duro brines is postulated to have been much greater in the geologic past. Aliphatic acid anions are but one of numerous petroleum proximity indicators, which consistently suggest a greater petroleum exploration potential for the area surrounding the Swisher County site than the region encompassing the candidate site in Deaf Smith County. Short-chain aliphatic acid anions appear to provide a useful petroleum exploration tool as long as the complex reactions that may dimish their concentrations in ground water are recognized. 71 refs., 10 figs., 10 tabs

Experience with reactor power cutback system at Palo Verde nuclear generating station

International Nuclear Information System (INIS)

Chari, D.R.; Rec, J.R.; Simoni, L.P.; Eimar, R.L.; Sowers, G.W.

1987-01-01

Palo Verde Nuclear Generating Station (PVNGS) is a three unit site which illustrates System 80 nuclear steam supply system (NSSS) design. The System 80 NSSS is the Combustion Engineering (C-E) standard design rated at 3817 Mwth. PVNGS Units 1 and 2 achieved commercial operation on February 13, 1986 and September 22, 1986, respectively, while Unit 3 has a forecast date for commercial operation in the third quarter of 1987. The System 80 design incorporates a reactor power cutback system (RPCS) feature which reduces plant trips caused by two common initiating events: loss of load/turbine trip (LOL) and loss of one main feedwater pump (LOMFWP). The key design objective of the RPCS is to improve overall plant availability and performance, while minimizing challenges to the plant safety system

77 FR 50185 - LoCorr Fund Management, LLC and LoCorr Investment Trust; Notice of Application

Science.gov (United States)

2012-08-20

... Fund Management, LLC and LoCorr Investment Trust; Notice of Application August 14, 2012. AGENCY.... Applicants: LoCorr Fund Management, LLC (``LFM'' or the ``Adviser'') and LoCorr Investment Trust (the ``Trust... Mary Kay Frech, Branch Chief, at (202) 551-6821 (Division of Investment Management, Office of...

Poe y lo grotesco moderno

Directory of Open Access Journals (Sweden)

David Roas

2014-10-01

Full Text Available Lo grotesco es una categoría estética que combina el humor y lo terrible (en sus muy diversas acepciones. Desde su primera manifestación carnavalesca, en la que la risa tiene un claro matiz festivo, lo grotesco ha ido evolucionando hacia posiciones donde, sin perder su dimensión humorística, se ha potenciado el componente siniestro, macabro, incluso terrorífico. Algunos cuentos de Edgar Allan Poe nos ofrecen una interesante encarnación de esa visión moderna de lo grotesco, con objetivos y formas variadas, que van desde la parodia y la sátira, a la manifestación más absurda y delirante de dicha categoría. Su análisis y comentario servirá también para alejar esos relatos de la órbita de lo fantástico, donde algunos críticos, equivocadamente, los han situado.

Use of probabilistic risk assessment in maintenance activities at Palo Verde

International Nuclear Information System (INIS)

Lindquist, R.C.; Pobst, D.S.

1993-01-01

Probabilistic risk assessment (PRA) is an important tool in addressing various maintenance activities. At the Palo Verde nuclear generating station (PVNGS), the PRA has been used in a variety of ways to support a wide and diverse selection of maintenance-related activities. For on-line or at-power maintenance, the PRA was used to evaluate combinations of maintenance activities possible with the 12-week or floating maintenance schedule. The maintenance schedule was evaluated to identify any higher risk, undesirable combinations of equipment outages, such as the sole steam-driven auxiliary feedwater pump and the same train emergency diesel generator. Table I is a sampling of the results from the maintenance schedule evaluation in terms of increase in conditional core damage frequency (CDF) above the base- line value due to maintenance on some important key safety systems and combinations thereof. The baseline CDF is 7.4 x 10 -7 per 72 h

Lo Strategic Management Accounting

OpenAIRE

G. INVERNIZZI

2005-01-01

Il saggio indaga gli aggregati informativi e gli elementi che compongono lo strategic management accounting. Sono quindi analizzate le funzioni svolte nei diversi stadi del processo di gestione strategica osservando il suo ruolo all’interno del management accounting. Infine sono approfonditi i rapporti fra i livelli della gestione strategica e lo strategic management accounting.

Una nueva ultraestructura de ópalo CT en silcretas. Posible indicador de influencia bacteriana

Directory of Open Access Journals (Sweden)

Bustillo, Mª A.

1995-04-01

Full Text Available Electron microscope observations of opaline silcretes found in the playa of a Miocene shallow lake reveal new opal CT microstructures. These microstructures are made up of fibres, filaments or rods, which are formed, in tum by coalesced microspheres or microhemispheres (0,1-0,2 µ diameter. They are up to 10 µ in length although larger ones could exist. They are straight, bent, wavy or even hairpin shaped. These microstructures comprise part of the opaline mass of the silcretes and are very similar to both neogenic opaline structures which are formed by bacterial intluence and to silicified biofilms. Therefore microbial mediation could exist in the genesis of this opal CT, although a possible inorganic origin by silicification of sepiolite is also considered.Un estudio mediante MEB de silcretas miocenas opalinas formadas por silicificación de playas en un ambiente de «playa-lake» pone de manifiesto la existencia de una nueva microestructura de ópalo CT. Esta microestructura denominada en general fibrosa, se manifiesta por la presencia de multitud de fibras, filamentos o varillas formadas por la alineación de microesferas o microhemisferas que presentan un diámetro entre 0,1 y 0,2 µ. Las fibras, filamentos o varillas tienen formas variables: rectas, curvadas, onduladas y «en horquilla», y presentan longitudes de hasta 10 µ, aunque podrían existir longitudes mayores. La disposición organizada de las microesferas en filamentos o fibras, constituyendo la masa general del ópalo, y su parecido con microestructuras opalinas que han sido formadas por influencia bacteriana, hacen considerar esta hipótesis, aunque no se puede descartar totalmente un origen inorgánico por silicificación de sepiolita.

LO PÚBLICO O LO PRIVADO: UN PRESUPUESTO DE VIRTUD EN ARISTÓTELES

Directory of Open Access Journals (Sweden)

Iván Cadavid

2010-01-01

Full Text Available Uno de los temas coyunturales de toda la teoría política del estagirita es el de lo público versus lo privado, desde el cual puede catalogarse la virtud o el vicio de un gobierno. Pero, entiéndase bien, para Aristóteles no puede existir una política buena o mala, que no devenga de una ética que la determine.De este modo, el tema de la virtud ética del gobernante, que es quienestá llamado a elegir entre lo público y lo privado, determina no solo su virtud sino también el futuro de una comunidad política. Pero aquí surge el problema, pues puede pensarse que si se privilegia al individuo se descuida a la sociedad, y a contrario sensu, si se privilegia la sociedad, se descuida al individuo. ¿Cómo sortear este problema? Ésta y otras cuestiones parecidas son las que se pretenden resolver en este artículo.

Redes sociales, lo público y lo político en construcción

Directory of Open Access Journals (Sweden)

Mauricio Velasco

2013-03-01

Full Text Available Si reconocemos que las transformaciones políticas conducen a las transformaciones en los espacios mediáticos y tecnológicos –y no al contrario, en una deificación tecnológica- las redes sociales serían una manifestación del surgimiento de los nuevos actores del siglo XXI, que tienen una forma diferente de organización -y expresión- política. Son actores que, además, responden a la irrupción de lo cultural en lo político o que plantean la ‘lucha’ cultural como una dimensión política. Lo cultural incluye aquello que se expresa fuertemente en las redes sociales: género, derechos, ambiente e incluso arte, pero también una postura ya no solo nacional, sino global y mundial con respecto a lo político.

El dolor y lo sagrado

Directory of Open Access Journals (Sweden)

Tornos Cubillo, Andrés

2002-04-01

Full Text Available Not available

En este trabajo no se trata del dolor mismo, sino de cómo se ha planteado el problema del dolor en relación con la experiencia de lo sagrado, entre personas y grupos que sufrían. Se recuerdan primero algunos hechos que tienen que ver con esta relación y luego se desarrolla lo que estos hechos sugieren: el dolor es un destino que nos sitúa en la perspectiva de nuestra mortalidad y finitud, y solamente en la elaboración libre de este límite se da la verdadera aceptación del mundo de Dios. En relación con lo sagrado el dolor marca sagradamente y crea un destino. Esto es lo importante.

Composition of fluid inclusions in Permian salt beds, Palo Duro Basin, Texas, U.S.A.

Science.gov (United States)

Roedder, E.; d'Angelo, W. M.; Dorrzapf, A.F.; Aruscavage, P. J.

1987-01-01

Several methods have been developed and used to extract and chemically analyze the two major types of fluid inclusions in bedded salt from the Palo Duro Basin, Texas. Data on the ratio K: Ca: Mg were obtained on a few of the clouds of tiny inclusions in "chevron" salt, representing the brines from which the salt originally crystallized. Much more complete quantitative data (Na, K, Ca, Mg, Sr, Cl, SO4 and Br) were obtained on ??? 120 individual "large" (mostly ???500 ??m on an edge, i.e., ??? ??? 1.6 ?? 10-4 g) inclusions in recrystallized salt. These latter fluids have a wide range of compositions, even in a given piece of core, indicating that fluids of grossly different composition were present in these salt beds during the several (?) stages of recrystallization. The analytical results indicating very large inter-and intra-sample chemical variation verify the conclusion reached earlier, from petrography and microthermometry, that the inclusion fluids in salt and their solutes are generally polygenetic. The diversity in composition stems from the combination of a variety of sources for the fluids (Permian sea, meteoric, and groundwater, as well as later migrating ground-, formation, or meteoric waters of unknown age), and a variety of subsequent geochemical processes of dissolution, precipitation and rock-water interaction. The compositional data are frequently ambiguous but do provide constraints and may eventually yield a coherent history of the events that produced these beds. Such an understanding of the past history of the evaporite sequence of the Palo Duro Basin should help in predicting the future role of the fluids in the salt if a nuclear waste repository is sited there. ?? 1987.

El genoma y sus metáforas. ¿Detectives, héroes o profetas?

Directory of Open Access Journals (Sweden)

Davo M.C.

2003-01-01

Full Text Available La «nueva genética», es decir, el impulso que esta disciplina toma a partir del denominado Proyecto Genoma, aspira a un cambio de paradigma en ciencias de la salud. Este cambio se postula desde una aproximación fenotípica de los problemas de salud hacia una aproximación genotípica, y por tanto excluyendo básicamente la influencia del medioambiente, lo que podría comprometer gravemente los fundamentos para el desarrollo y el ejercicio de la salud pública. Desde que empezó a desarrollarse el Proyecto Genoma, los nuevos descubrimientos genéticos se convirtieron en temas frecuentes de noticias en los medios de comunicación de masas. En este sentido, tanto genetistas como periodistas suelen utilizar metáforas para dar a conocer los conceptos complejos de la investigación genética para los que no existen bases en el lenguaje profano. Cabe señalar que los medios de comunicación no sólo modelan el establecimiento de la agenda social, sino que son también el espacio donde se conforma la cultura de salud de la población. Se presentan los resultados de un estudio preliminar en el que se exploran las metáforas utilizadas en los tres diarios de mayor difusión nacional (ABC, El País y El Mundo en relación con las noticias sobre la «nueva genética» y se plantean las posibles consecuencias para la cultura de salud que puede tener la historia natural o el proceso catacrético de estas metáforas, mediante el cual se traslada el sentido figurativo de un término al sentido literal. En el proceso de revisión se ha desarrollado una taxonomía preliminar de las metáforas encontradas. Un 14,8% de los titulares identificados (51 de 342 contenía metáforas. Las metáforas estratégicas, como «programa», «control», «código», «mapa» o «puzle» son las más utilizadas, seguidas de las teleológicas, con términos como «misterio» o «lenguaje de Dios», y por último las bélicas, como «ataque», «derrota» o «captura». Los

Palinofloras de las formaciones El Morterito y Palo Pintado [Mioceno Superior-Plioceno Inferior], noroeste de Argentina

OpenAIRE

Horn, Maricel Yanina

2014-01-01

En esta Tesis Doctoral se presenta el estudio palinológico de dos unidades litológicas del Mioceno Tardío/Plioceno de Argentina: la Formación El Morterito (Aloformación Playa del Zorro) aflorante en el valle del Cajón, provincia de Catamarca y Formación Palo Pintado en el Valle Calchaquí, provincia de Salta. La sucesión Neógena del valle del Cajón fue primeramente descripta como Formación El Morterito, posteriormente se reconocieron tres Aloformaciones. Considerando las áreas de distribución ...

Lo fantástico europeo y lo fantástico latinoamericano

OpenAIRE

Arcila Buendía, Luz Betty

2016-01-01

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Filosofía y Letras, Departamento de Lingüística, Lenguas Modernas, Lógica y Tª de la Ciencia y Tª de la Literatura y Literatura Comparada. Fecha de lectura: 17-06-2016 En esta tesis reconocimos las diferencias y similitudes entre lo fantástico europeo y lo fantástico latinoamericano mediante la categorización de los rasgos de la narración fantástica a partir de las aportaciones teóricas de Tzvetan Todorov,...

Lo que decimos es

Directory of Open Access Journals (Sweden)

Victoria Elena González M.

2003-10-01

Full Text Available La vigencia dela cosmovisión maya, el poder de la palabra y la recuperación del sentido en la simbología son tres características que identifican al movimiento Zapatista y que lo proyectan mucho más allá de las denuncias sobre la explotación y la pobreza hechas por tantos movimiento sociales y tantas guerrillas a lo largo de la historia.

Espacio y subjetividad. Orden social desde lo privado y lo público

OpenAIRE

Graciela Vélez Bautista

2005-01-01

En este artículo se plantea la relación entre subjetividad, espacio y género como uno de los enfoques que explican la identificación de los hombres con el espacio público y de las mujeres con el espacio privado, desde una perspectiva cultural e histórica, cuya huella en la subjetividad prevalece a pesar de las transformaciones modernas en la concepción de lo femenino y masculino, así como de lo privado y público.

Aproximación a la incidencia de la metáfora en el discurso político -Discurso del poder-

OpenAIRE

LUZ AMPARO FAJARDO URIBE

2012-01-01

La metáfora es un recurso retórico empleado en el discurso político - discurso del poder para lograr la comprensión efectiva de la intención de quien lo emplea. Estas metáforas están relacionadas con los diferentes tipos de ingredientes que se emplean dentro de un discurso político – discurso de poder, a saber: el discurso de la economía, el discurso de la biología, el discurso de la salud, el discurso de la guerra, el discurso religioso. A través de cada uno de estos discursos se busca mostr...

Palo Verde Nuclear Generating Station: an example of the state role in regional nuclear projects

International Nuclear Information System (INIS)

Pasternak, A.

1980-10-01

A nuclear power plant siting policy which confines new construction to existing sites will lead to the formation of large regional power centers, each involving many utilities from several states. The Palo Verde Nuclear Project in Arizona has been examined in terms of the role state regulation plays in large regional nuclear projects. State regulatory processes do not reflect the regional nature of large power centers. Decisions and actions by individual state regulatory commissions create risk and uncertainty for all the utility participants in regional projects. A climate and mechanism to encourage and facilitate interstate cooperation are needed to enhance the viability of the confined siting policy and the regional power center concept

Estudio de viabilidad de una instalación fotovoltaica para una vivienda unifamiliar situada en Cabo de Palos

OpenAIRE

Sánchez Ros, Adrián Antonio

2015-01-01

El presente proyecto tiene por objetivo el análisis técnico y económico de una instalación fotovoltaica en una vivienda unifamiliar ubicada en Cabo de Palos (Cartagena), planteando distintas alternativas de conexión o no a la red: - Instalación fotovoltaica conectada a red, dedicadas a la inyección a la red y venta de la energía eléctrica. - Instalación fotovoltaica aislada, dedicadas al autoconsumo de la electricidad generada. - Instalación fotovoltaica de autoconsumo in...

Decontamination and disposal of Sb-124 at Palo Verde Nuclear Generating Station

International Nuclear Information System (INIS)

Miller, A.D.; Hillmer, T.P.; Kester, J.W.; Hensch, J.R.

1988-01-01

Palo Verde Nuclear Generating Station (PVNGS) is a three unit Combustion Engineering pressurized water reactor site. Each unit consists of an identical, self contained 1270 MWe reactor. This standardized design allows sharing of design improvements and equipment leading to optimum operation of the individual units. One design improvement, identified early into the operation of Unit 1, involved the elemental antimony content of the seals and bearings within the reactor coolant pumps. Normal wear of these components releases small amounts of elemental antimony. This antimony in turn deposits on in-core surfaces and activates to produce the isotopes Sb-122 and Sb-124. These isotopes emit highly energetic gamma rays which contribute significantly to the exposure and radwaste disposal charges at PVNGS. For these reasons, the Antimony Removal Program was undertaken to remove the radioactive and elemental antimony from the nuclear steam supply system at all three units. The work presented here describes the antimony decontamination and disposal

Ruumist animatsioonfilmis / Ülo Pikkov

Index Scriptorium Estoniae

Pikkov, Ülo, 1976-

2006-01-01

Animafilmi visuaalsest keskonnast,selle osast filmi süžee edastamisel. Artiklis viited ka Juri Lotmanile ("Filmisemiootika", Varrak, 2004), Platonile, Ülo Soosterile (Ilja Kabakov "Ülo Soosteri piltidest" Kunst, 1996), Martin Heideggerile ("Kunstiteoste algupära"), Arthur Schopenhauerile. Näited filmidest "Lõvikuningas" (R. Allers, R., Minkoff) ja "Kes lavastas süüdi Roger Rabbiti?" (R. Zemeckis)

Lo registral civil desde lo electoral

OpenAIRE

Arlette Bolaños Barquero

2018-01-01

En este trabajo se aborda la naturaleza jurídica del Registro Civil de Costa Rica y se intenta proveer elementos para comprender la decisión de los constituyentes, en 1949, acerca de su adscripción en definitiva al Tribunal Supremo de Elecciones (también lo llamaremos TSE) y de cómo, con el devenir del tiempo y en la práctica actual, se ha estrechado la relación e interdependencia entre este organismo y el TSE, para la correcta ejecución de las tareas que se deben cumplir en las diferentes di...

Flooding studies of proposed repository locations in the Palo Duro Basin of the Texas Panhandle

International Nuclear Information System (INIS)

1985-04-01

This report contains the results of flooding studies of those stream channels that drain the proposed locations of a high-level nuclear-waste repository in Deaf Smith and Swisher Counties, Texas. Included are computations of the flood hydrographs and water surface profiles of the 100-year, 500-year, and probable maximum floods for Palo Duro Creek, Tule Creek, and Pleasant Draw. The hydrographs were produced according to the method of the Soil Conservation Service for ungaged watersheds, and the computations were made with computer programs developed by the US Army Corps of Engineers. The flood hydrographs were computed with the HEC-1 Flood Hydrograph Package and the water surface elevations with the HEC-2 Water Surface Profiles program. 76 refs., 19 figs., 16 tabs

Area environmental characterization report of the Dalhart and Palo Duro basins in the Texas Panhandle. Volume I. Dalhart Basin

International Nuclear Information System (INIS)

1982-09-01

This area report describes the environmental characteristics of the Dalhart and Palo Duro basins of the Texas Panhandle portion of the Permian basin. Both basins are rather sparsely populated, and the overall population is decreasing. The economic base is centered on agribusiness and manufacturing. Most of the potentially conflicting land uses in both basins (i.e., parks, historic sites) occupy small land areas, with the exception of a national grassland in the Dalhart and military air training routes in both basins. Ground transportation in the Dalhart basin is adequate, and it is well developed in the Palo Duro basin. In both basins irrigation constitutes the principal water use, and groundwater is the principal source. However, the dominant aquifer, the Ogallala, is being depleted. Both basins consist primarily of grasslands, rangelands, and agricultural areas. No critical terrestrial or aquatic habitats have been identified in the basins, though several endangered, threatened, or rare terrestrial species occur in or near the basins. Aquatic resources in both basins are limited because of the intermittent availability of water and the high salt content of some water bodies. Playa lakes are common, though usually seasonal or rain dependent. The climate of the area is semiarid, with low humidity, relatively high wind speeds, and highly variable prcipitation. Restrictive dispersion conditions are infrequent. National ambient secondary air quality standards for particulates are being exceeded in the area, largely because of fugitive dust, although there are some particulate point sources

De lo invisible y lo cotidiano. Familias y discapacidad

Directory of Open Access Journals (Sweden)

Sandra Araya Umaña

2007-01-01

Full Text Available La construcción social de la realidad comporta un pensamiento dicotómico que asocia la discapacidad con el par normal – anormal lo que favorece procesos de exclusión social de las personas con discapacidad y sus familias. A su vez, el concepto de familia se finca en un modelo construido social y culturalmente que privilegia la subordinación de otras formas de organización familiar pues este modelo es el que se considera normal. Tanto el concepto de familia como el de discapacidad contienen una carga ideológica cuya pretensión es la prescripción y con ella lo que se favorece es la proscripción. A partir de la teoría de las representaciones sociales, este artículo aborda las dinámicas que surgen de la vinculación de ambos conceptos con el fin de evidenciar los caminos recorridos y los que aun falta recorrer para el logro de una sociedad inclusiva.

Pele Erupting on Lo

Science.gov (United States)

2001-01-01

This image of Jupiter's moon, lo, was taken by the Chandra X-Ray Observatory (CXO). Shown here is the most extreme example of the effect of tidal forces as Lo is being pulled by massive Jupiter on one side and by the outer moons Europa, Callisto, and Ganymede on the other. The opposing tidal forces alternately squeeze and stretch its interior, causing the solid surface to rise and fall by about 100 meters. The enormous amount of heat and pressure generated by the resulting friction creates colossal volcanoes and fractures on the surface of this moon.

Keystone Life Orientation (LO) teachers: Implications for educational ...

African Journals Online (AJOL)

Keystone Life Orientation (LO) teachers: Implications for educational, social, and ... characteristics and support networks needed by keystone Life Orientation (LO) ... In this study “keystone” refers to LO teachers who make a positive impact in ...

Gezondheidsrisico's in verband met het werken met Pentachloorfenol : een onderzoek

NARCIS (Netherlands)

Geuskens, R.B.M.; Nossent, S.M.; Koëter, H.B.W.M.; Dreef-van der Meulen, H.C.; Stijkel, A.; Zielhuis, R.l.

1989-01-01

De gezondheidsrisico's i.v.m. het werken met pentachloorfenol (PCP) wordt geevalueerd. Het gebruik van PCP in Nederlandse arbeidssituaties neemt sterk af en is beperkt tot de formulering van emeltenkorrels en de, met name preventieve, houtverduurzaming. De totale risicopopulatie is niet omvangrijk

EL ESPACIO ANEXO ENTRE LO ARTIFICIAL Y LO NATURAL / The annexed space between the natural and the artificial

Directory of Open Access Journals (Sweden)

Juan José Tuset Davó

2011-11-01

Full Text Available RESUMEN En la ciudad contemporánea, lo público está perdiendo relevancia respecto a lo privado. Presenciamos, además, una insistencia en encontrar y recuperar el equilibrio entre ambos. Ante la pregunta de cuál es la forma adecuada que la arquitectura da a los espacios donde lo público encuentra su lugar, vemos que a lo largo de la modernidad, en las utopías socialistas del siglo XIX, en los experimentos de vivienda social europea, oculto en la ciudad suburbana norteamericana, en los revisionismos de los años 70 y en la nueva vivienda colectiva de los años 90, existen unos espacios anexos a la arquitectura que pretenden complementarla y corregir la progresiva sustitución de lo público por lo privado. Actualmente, el activismo pasivo urbano aprovecha cualquier oportunidad en la ciudad para reivindicar el encuentro colectivo. Este planteamiento radica en la firme voluntad de diseñar escenarios urbanos donde lo público encuentre acomodo. Para ello, la constitución del suelo como un plano moldeable acompañado por una cobertura arbórea nos ofrece las condiciones esenciales para que la gente se encuentre bien en un lugar. Entre lo artificial y lo natural, es posible pensar que hay un espacio anexo arquitectónico que se abre a los acontecimientos imprevistos para que tenga lugar otro sentido de lo público. SUMMARY In the contemporary city, what is public is losing importance with respect to what is private. Witness also, an insistence on finding and recovering the balance between them. The appropriate way that architecture makes spaces for what is public can be seen throughout modernity: in the socialist utopias of the nineteenth century; in the European social housing experiments; hidden in the North American suburban town; in the revisionism of the 70’s, and, in the new collective housing of the 90’s, there are spaces annexed to the architecture which are intended to complement and correct the progressive change from public to

Modeling the Energy Performance of LoRaWAN.

Science.gov (United States)

Casals, Lluís; Mir, Bernat; Vidal, Rafael; Gomez, Carles

2017-10-16

LoRaWAN is a flagship Low-Power Wide Area Network (LPWAN) technology that has highly attracted much attention from the community in recent years. Many LoRaWAN end-devices, such as sensors or actuators, are expected not to be powered by the electricity grid; therefore, it is crucial to investigate the energy consumption of LoRaWAN. However, published works have only focused on this topic to a limited extent. In this paper, we present analytical models that allow the characterization of LoRaWAN end-device current consumption, lifetime and energy cost of data delivery. The models, which have been derived based on measurements on a currently prevalent LoRaWAN hardware platform, allow us to quantify the impact of relevant physical and Medium Access Control (MAC) layer LoRaWAN parameters and mechanisms, as well as Bit Error Rate (BER) and collisions, on energy performance. Among others, evaluation results show that an appropriately configured LoRaWAN end-device platform powered by a battery of 2400 mAh can achieve a 1-year lifetime while sending one message every 5 min, and an asymptotic theoretical lifetime of 6 years for infrequent communication.

Modeling the Energy Performance of LoRaWAN

Directory of Open Access Journals (Sweden)

Lluís Casals

2017-10-01

Full Text Available LoRaWAN is a flagship Low-Power Wide Area Network (LPWAN technology that has highly attracted much attention from the community in recent years. Many LoRaWAN end-devices, such as sensors or actuators, are expected not to be powered by the electricity grid; therefore, it is crucial to investigate the energy consumption of LoRaWAN. However, published works have only focused on this topic to a limited extent. In this paper, we present analytical models that allow the characterization of LoRaWAN end-device current consumption, lifetime and energy cost of data delivery. The models, which have been derived based on measurements on a currently prevalent LoRaWAN hardware platform, allow us to quantify the impact of relevant physical and Medium Access Control (MAC layer LoRaWAN parameters and mechanisms, as well as Bit Error Rate (BER and collisions, on energy performance. Among others, evaluation results show that an appropriately configured LoRaWAN end-device platform powered by a battery of 2400 mAh can achieve a 1-year lifetime while sending one message every 5 min, and an asymptotic theoretical lifetime of 6 years for infrequent communication.

A novel feedwater system for the RETRAN model of the Palo Verde nuclear generating station

International Nuclear Information System (INIS)

Secker, P.A.; Webb, J.R.

1988-01-01

This paper presents a feedwater system model which supplies realistic boundary conditions to the RETRAN model of a Palo Verde Nuclear Generating Station reactor plant. The RETRAN thermal hydraulic code is used to analyze nuclear reactor system transients through a generalized thermal hydraulic volume/junction network. The feedwater system model is implemented using the control block modeling option available in the RETRAN code. The output of the control block model is coupled to the thermal hydraulic network by a fill junction. A forward Euler integration scheme is used by RETRAN for control block variables. The feedwater system model is formulated to allow implicit integration within the existing code framework. The potential need for small integration time steps is, therefore, alleviated. The model results are compared with test data

Posconflicto y el retorno a lo comunitario

Directory of Open Access Journals (Sweden)

Gil, María Fernanda

2016-09-01

Full Text Available El presente ejercicio reflexivo y crítico es expresión del proyecto de investigación que se viene adelantando: Enfoque pedagógico del desarrollo humano para la ciudadanía crítica-activa y la no-violencia en las organizaciones comunitarias de zona de ladera, de la ciudad de Santiago de Cali, el cual busca tejer desde un diálogo con los diversos saberes comunitarios, una propuesta pedagógica que acompañe a fundamentar ética y políticamente gobernabilidades que desde el desarrollo humano tenga como preocupación la dignificación de la vida. En este orden de ideas se planteará como el desarrollo humano lleva a pensarse el concepto de necesidad más allá de la carencia, en el momento que invita a realizar un retorno a los procesos de autonomía y subjetividad con la comunidades, mirando como la pedagogía crítica a través de la palabra acto, se constituye en una de las operadoras de tal ejercicio, que pasa por hacerla de la palabra, actos de coherencia con lo que acontece en los ámbitos cotidianos, donde las lógicas son el construir comunidades de abajo hacia arriba y no a la inversa. Por ello dicho ejercicio del desarrollo humano que rescate las autonomías comunitarias con el acompañamiento de lo pedagógico, puestas de cara al momento del proceso de paz y particularmente al posconflicto hace un llamado del retorno a lo comunitario, como aquellos procesos singulares de tejer propuestas venidas de lo cotidiano, de lo local, que generadas desde lógicas del sentir, restituyan comunidades constructoras de sus propios destinos, donde no tengan cabida lógicas racionales que sólo miden el impacto del avance tecnológico científico, donde se olvida el sentido de tener una existencia en libertad y convivencia mutua de lo humano con la naturaleza, lo cual quizás obligue a deconstruir formas de pensar donde la palabra este en coherencia con lo que se dice y de hace.

Modeling the Energy Performance of LoRaWAN

OpenAIRE

Casals, Lluís; Mir, Bernat; Vidal, Rafael; Gomez, Carles

2017-01-01

LoRaWAN is a flagship Low-Power Wide Area Network (LPWAN) technology that has highly attracted much attention from the community in recent years. Many LoRaWAN end-devices, such as sensors or actuators, are expected not to be powered by the electricity grid; therefore, it is crucial to investigate the energy consumption of LoRaWAN. However, published works have only focused on this topic to a limited extent. In this paper, we present analytical models that allow the characterization of LoRaWAN...

Lo Transindividual: de Simondon a Marx

Directory of Open Access Journals (Sweden)

Daniel Alvaro

Full Text Available RESUMEN: El presente artículo trata de lo transindividual, un concepto fundamental en la teoría de la individuación elaborada por Gilbert Simondon (1924-1989, y de su vinculación con ciertas proposiciones de Karl Marx que tratan del individuo y la sociedad. Entre ambos autores existe una relación directa, evidenciada en cada uno de los textos donde Simondon hace mención a Marx y al marxismo en general. Pero también existe una relación indirecta, para nada evidente, que surge menos de lo que Simondon dice acerca de Marx que de lo que ciertos pensadores contemporáneos dicen sobre uno y otro. Aquí intento dar cuenta de ambos tipos de relaciones. Asimismo, me propongo introducir y comentar algunos pasajes de Marx que compiten en radicalidad y audacia con los que escribiera Simondon un siglo más tarde, y en los cuales quiero apoyar mi hipótesis de lectura, a saber, que Marx es un pensador de lo transindividual avant la lettre.

Comprensión lectora: interpretación y traducción de metáforas en inglés académico

Directory of Open Access Journals (Sweden)

Elena Carlsen de Escudero

2011-04-01

Full Text Available Traducir consiste en interpretar un mensaje y reexpresar lo comprendido usando tanto conocimientos lingüísticos como enciclopédicos, considerando los elementos constitutivos existentes en el texto y en su contexto. El objetivo es mostrar cómo influyen la cultura y el conocimiento enciclopédico en la interpretación de metáforas, siguiendo procedimientos de traducción en un enfoque interactivo de lectura. Se analizaron las metáforas en los textos utilizados en las cátedras de lecto-comprensión en inglés en la universidad. También se estudiaron las diferentes condiciones de proyección y la problemática del sentido de las metáforas en las distintas culturas. Se sugiere a las docentes estrategias para guiar a los lectores noveles en su interpretación.

Lo social y lo virtual (Francisco Tirado Serrano y Miquel Domènech i Argemí, Eds.

Directory of Open Access Journals (Sweden)

Tomás Sánchez-Criado

2008-01-01

Full Text Available Lo social y lo virtual” se trata principalmente de un libro conceptual que trabaja a través de ejemplos empíricos (por ejemplo, la teleasistencia y la transformación del espacio del cuidado social, las pulseras electrónicas y los cambios en las tecnologías de vigilancia.

Lipid ratio as a suitable tool to identify individuals with MetS risk: A case- control study.

Science.gov (United States)

Abbasian, Maryam; Delvarianzadeh, Mehri; Ebrahimi, Hossein; Khosravi, Farideh

2017-11-01

This study aimed to compare the serum lipids ratio in staff with and without metabolic syndrome (MetS) who were working in Shahroud University of Medical Sciences. This case-control study was conducted in 2015 on 499 personnel aged 30-60 years old. ATP III criteria were used to diagnose patients with MetS. The data were analyzed by using logistic regression and ROC curve. Mean lipid ratio was higher in individuals having the MetS in both sexes compared with those without. In addition, the mean levels of lipid ratios significantly increased with increasing number of MetS components in both sexes. Also it could be concluded that TG/HDL-C ratio is the best marker for the diagnosis of MetS in men and women. Moreover, the cut-off point for the TG/HDL-C was 2.86 in women and 4.03 in men. It was found that for any unit of increases in the TG/HDL-C, the risk of developing the MetS will increase by 2.12 times. TG/HDL-C ratio is found to be the best clinical marker for the diagnosis of MetS compare with other lipid ratios, therefore it is recommended to be used as a feasible tool to identify individuals with MetS risk. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Variaciones sobre lo raro

Directory of Open Access Journals (Sweden)

Carina Blixen

2010-07-01

Full Text Available “Ser raro es normal” dice una pintada en un muro de la calle Chaná, ubicado entre Pablo de María y Joaquín de Salterain, en el barrio Cordón, en Montevideo. A dos cuadras de allí vivo ; he pasado delante de ese muro una y otra vez mientras rumiaba la necesidad de sentarme a escribir este trabajo. Cuando me decidí a hacerlo me di cuenta de que ahí estaba la clave : el muro me decía lo que yo no podía ver todavía. La noción de lo raro se ha perdido en la disolución de fronteras.Ese alguien a ...

Influence of geological factors on the mechanical properties of rock in the Palo Duro Basin

International Nuclear Information System (INIS)

Cregger, D.M.; Corkum, D.H.; Gokce, A.O.; Peck, J.H.

1985-01-01

Sedimentary formations in the Palo Duro Basin of the Texas Panhandle exhibit a variety of petrofabrics which contribute to different mechanical behavior. Similarly classified rock core specimens, upon closer inspection, are comprised of different textures and slight compositional variations. The resultant rock mass characteristics interpreted from laboratory tests and deep borehole geophysical logs are seen to be a direct result of the depositional environment and geologic history. Depositional environments include chemical precipitation in shallow brine pools, basin filling with terrigenous or eolian supply of clastics, restricted circulation, and transgression of normal marine waters. Geochemical transformations of the deposits, (diagenesis), can or may result in profound changes to the mechanical properties of the rock. Structural deformation of the bedded salts is slight and may be far less important in its effect on mechanical properties than diagenetic changes

Nuevos recipientes rituales metálicos: la problemática de su distribución peninsular

OpenAIRE

Caldentey Rodríguez, Paz; López Cachero, Javier; Menéndez Bueyes, Luis Ramón

2009-01-01

RESUMEN: La aparición y estudio de nuevos recipientes rituales metálicos con soportes de manos de los tipos I y II de Cuadrado en diversos yacimientos, nos ha permitido relacionar la distribución de todos estos objetos documentados a lo largo y ancho de toda la geografía peninsular con la explotación comercial de las diferentes vías de comunicación hacia el interior de la Península Ibérica, principalmente, entre los siglos VII y IV aC.ABSTRACT: The appearance and study of new ritual metallic ...

C-MET overexpression and amplification in gliomas.

Science.gov (United States)

Kwak, Yoonjin; Kim, Seong-Ik; Park, Chul-Kee; Paek, Sun Ha; Lee, Soon-Tae; Park, Sung-Hye

2015-01-01

We investigated c-Met overexpression and MET gene amplification in gliomas to determine their incidence and prognostic significance. c-Met immunohistochemistry and MET gene fluorescence in situ hybridization were carried out on tissue microarrays from 250 patients with gliomas (137 grade IV GBMs and 113 grade II and III diffuse gliomas). Clinicopathological features of these cases were reviewed. c-Met overexpression and MET gene amplification were detected in 13.1% and 5.1% of the GBMs, respectively. All the MET-amplified cases showed c-Met overexpression, but MET amplification was not always concordant with c-Met overexpression. None of grade II and III gliomas demonstrated c-Met overexpression or MET gene amplification. Mean survival of the GBM patients with MET amplification was not significantly different from patients without MET amplification (P=0.155). However, GBM patients with c-Met overexpression survived longer than patients without c-Met overexpression (P=0.035). Although MET amplification was not related to poor GBM prognosis, it is partially associated with the aggressiveness of gliomas, as MET amplification was found only in grade IV, not in grade II and III gliomas. We suggest that MET inhibitor therapy may be beneficial in about 5% GBMs, which was the incidence of MET gene amplification found in the patients included in this study.

Lo spazio e la definizione del mondo sociale

Directory of Open Access Journals (Sweden)

Veronica Polese

2015-07-01

Full Text Available In questi ultimi venti anni abbiamo vissuto in Italia una sempre maggiore attenzione alla violenza maschile verso le donne. Attenzione mediatica, attenzione politica, attenzione delle persone e delle comunità. La pratica di ascolto e relazione con donne in difficoltà a causa di violenza iniziata nella seconda metà degli anni ottanta è divenuta un discorso sociale sulla violenza maschile verso le donne, affermando nuovi paradigmi interpretativi e permettendo l’emersione di un problema strutturale della società, della cultura, del simbolico che ci iscrive nel mondo. Quella pratica ha determinato la possibilità di modificare un contesto che non aveva parole né rappresentazioni della violenza verso le donne, se non per la loro vittimizzazione salvifica di alcuni valori fondanti la società quale la famiglia. Il processo iniziato allora e nato nella fase finale del dibattito intorno alla nuova legge sulla violenza sessuale provava a dare una nuova risposta che aprisse lo spazio alla parola e ad un percorso di libertà femminile. Questa pratica ha accompagnato la nascita dei centri antiviolenza in Italia, con un processo creativo caratterizzato dal riconoscimento di autorità femminile nel percorso di cambiamento del reale in materia di violenza maschile verso le donne.

Samen in Zee met Zelfregulatie: Een Design-Based Aanpak met Vmbo Leraren

NARCIS (Netherlands)

Jossberger, Helen; Brand-Gruwel, Saskia; Boshuizen, Els; Van de Wiel, Margje

2010-01-01

Jossberger, H., Brand-Gruwel, S., Boshuizen, H. P. A., & Van der Wiel, M. (2010, June). Samen in Zee met Zelfregulatie: Een Design-Based Aanpak met Vmbo Leraren. Poster presented at the 37th Onderwijs Research Dagen (ORD), Enschede, Nederland.

La metáfora de lo uno-múltiple: una (re-conceptuación dialógica de la identidad personal (una crítica al reduccionismo ?posmodernista?

Directory of Open Access Journals (Sweden)

Marcos Engelken Jorge

2005-05-01

Full Text Available En este trabajo pretendo corregir algunos de los ?excesos? y simplificaciones de las teorías posmodernistas sobre la identidad. Trato de restituir al sujeto una ontología que no lo reduzca a meras determinaciones sociales, recuperar su carácter corpóreo-orgánico (embodiment para su comprensión/construcción y, de este modo, retomar la cuestión de la unidad del sujeto (y de la unidad de/en su identidad frente a la manida exaltación de su fragmentación (pluralidad de su identidad; en oposición a lo cual sostengo la idea de una ?pluralidad de/en su identidad?.

Seafloor mapping of the southeast Iberian margin (from Cabo de Palos to Cabo de Gata)

Science.gov (United States)

Lastras, Galderic; Leon, César; Elvira, Elena; Pascual, Laura; Muñoz, Araceli; de Cárdenas, Enrique; Acosta, Juan; Canals, Miquel

2014-05-01

We present the multibeam bathymetry and derived maps of the southeast Iberian margin from Cabo de Palos to Cabo de Gata, 37º35'N to 35º45'N and 2º10'W to 0º20'E, from the coastline down to the Algero-Balearic abyssal plain at depths exceeding 2600 m. The edition of of the maps is carried out within the Complementary Action VALORPLAT ("Scientific valorisation of multibeam bathymetry data from the Spanish continental shelf and slope"), funded by the Spanish Ministry of Economy and Competitivity. The multibeam bathymetry data of the slope and abyssal plain were obtained during different surveys in 2004, 2006 and 2007 on board R/V Vizconde de Eza with a Simrad EM300 multibeam echo-sounder as part of the CAPESME Project, a collaboration between the Spanish Institute of Oceanography (IEO) and General Secretariat of Fisheries (SGP), primarily aiming at creating maps of the fishing grounds of the Mediterranean continental margins of Spain. Multibeam bathymetry data from the continental shelf were obtained within the ESPACE project, also in a cooperative frame between IEO and SGP. The map series is constituted by a general map at 1:400,000 scale and 14 detailed maps at 1:75,000 scale, which include inset maps on slope gradients and seafloor nature (rock or sediment type), the later obtained with rock dredges and Shipeck sediment dredges. Both the detailed maps and the general map are available in paper print, and the whole collection is also distributed in an edited USB. The geological features displayed in the different maps include the continental shelf, with abundant geomorphic features indicative of past sea-level changes, the continental slope carved by the Palos, Tiñoso, Cartagena Este, Cartagena Oeste, Águilas, Almanzora, Alias, Garrucha and Gata submarine canyons, the Mazarrón, Palomares and Al-Mansour escarpments, the Abubácer, Maimonides and Yusuf ridges, the Águilas and Al-Mansour seamounts, and the Algero-Balearic abyssal plain where prominent

IoT devices and applications based on LoRa/LoRaWAN

CSIR Research Space (South Africa)

Khutsoane, Oratile C

2017-10-01

Full Text Available such as smart water management systems. However, they require high energy-efficient sensor nodes that are able to communicate across long distance. This motivates the development of many Low-Power Wide Area Networks (LPWAN) technologies, such as LoRa, to fulfill...

Metódica: Articulación sistema teórico, fenómeno y procesos en el objeto de estudio. Una perspectiva desde el fenómeno pobreza

Directory of Open Access Journals (Sweden)

Yajaira Jiménez Zabala

2011-10-01

Full Text Available En este artículo discutimos la visión metódica que toma como apoyo el pivote entre lo cualitativo, lo cuantitativo y el orden de complejidad, en un enfoque plurimetódico, a través del cual se construyó la visión de la pobreza como objeto de estudio. Tal selección, está justificada en tanto se entiende la pobreza como un fenómeno social complejo, por las diversas aristas que le identifican. La combinación de los enfoques metodológicos permitió la aprehensión de los diferentes aspectos del fenómeno y de sus interrelaciones en las representaciones de los actores sociales vinculados con el estudio. Lo cualitativo, se entiende como la simbiosis de prácticas interpretativas, que no privilegia una metodología sobre otra. Lo cuantitativo estuvo referido al uso de indicadores derivados de los soportes referenciales del problema; el orden de complejidad, atendió a la manifestación de lo simple en tanto nodo tensional complejo, que requiere una mirada diferente para su comprensión e interpretación.

Mitigating Inter-Network Interference in LoRa Networks

OpenAIRE

Voigt, Thiemo; Bor, Martin; Roedig, Utz; Alonso, Juan

2017-01-01

Long Range (LoRa) is a popular technology used to construct Low-Power Wide-Area Network (LPWAN) networks. Given the popularity of LoRa it is likely that multiple independent LoRa networks are deployed in close proximity. In this situation, neighbouring networks interfere and methods have to be found to combat this interference. In this paper we investigate the use of directional antennae and the use of multiple base stations as methods of dealing with inter-network interference. Directional a...

Pumping test and fluid sampling report - Sawyer No. 1 well, Palo Duro Basin, Texas: unanalyzed data

International Nuclear Information System (INIS)

1984-05-01

This report describes pumping test and fluid sampling activities performed at the Sawyer No. 1 well, Donley County, Texas. Sawyer No. 1 well is located along the eastern margin of the Palo Duro Basin in an area of active dissolution within the Permian salt section. These data were collected by Stone and Webster Engineering Corporation working in conjunction with the Texas Bureau of Economic Geology as part of a nationwide program to identify potential locations for a nuclear waste repository. These data support studies to determine the hydrologic characteristics of deep water-bearing formations. Formation fluid studies samples were analyzed in order to evaluate fluid migration and age relationships in the Permian Basin. These data were collected from June until October, 1981. Zone isolation for pump testing was accomplished in November, 1981. These data are preliminary. They have been neither analyzed nor evaluated

Metódica: Articulación sistema teórico, fenómeno y procesos en el objeto de estudio. Una perspectiva desde el fenómeno pobreza

OpenAIRE

Yajaira Jiménez Zabala

2011-01-01

En este artículo discutimos la visión metódica que toma como apoyo el pivote entre lo cualitativo, lo cuantitativo y el orden de complejidad, en un enfoque plurimetódico, a través del cual se construyó la visión de la pobreza como objeto de estudio. Tal selección, está justificada en tanto se entiende la pobreza como un fenómeno social complejo, por las diversas aristas que le identifican. La combinación de los enfoques metodológicos permitió la aprehensión de los diferentes aspectos del fenó...

de lo jurídico

Directory of Open Access Journals (Sweden)

José Julián Suárez Rodríguez

2007-01-01

Full Text Available El pensamiento jurídico moderno ha intentado abordar el estudio de lo jurídico con una mirada exclusivamente teórica, es decir, ha intentado hacer una descripción del fenómeno jurídico y elaborar un sistema lo más adecuado posible para explicar dicho fenómeno, a la manera como las ciencias naturales escogen un sector de la realidad para describirla, elaborando un modelo que la explique de la mejor manera posible. Esta forma de abordar lo jurídico tiene como origen la influencia de la moderna filosofía racionalista, el auge que las ciencias físicas toman a partir de los Principia mathemáthica de Newton, y el querer asimilar toda ciencia a las ciencias de la naturaleza que daban, según los modernos, mejores y más efectivos resultados. la consecuencia de este fenómeno fue la negación de lo complejo de la realidad; la distinción entre razón teórica y razón práctica pierde todo su sentido, y el derecho pierde su carácter de ciencia práctica y prudencial. Por ello se hace necesario recuperar el nivel prudencia de la ciencia jurídica para que responda de manera más adecuada a la naturaleza de su objeto: si la realidad jurídica es una realidad práctica, que busca la resolución de casos concretos, debe buscarse un método que se adecue a esta naturaleza del objeto, y no seguir queriendo adaptar el método de las ciencias teóricas al objeto jurídico.

Sereniteit met een dip

NARCIS (Netherlands)

dr Ed de Jonge

2015-01-01

Boekbespreking van Serendipiteit. De ongezochte vondst. Het boek opent met een verzameling van citaten die direct of indirect met het onderwerp samenhangen. Daarna volgt een kort voorwoord van Hans Clevers, de toenmalige president van de KNAW, die een lans breekt voor serendipiteit in de biologie.

SOBRE LO OBJETIVO, LO SUBJETIVO Y LO CAPRICHOSO EN ARQUITECTURA / On the objective, the subjective and the capricious in Architecture

Directory of Open Access Journals (Sweden)

Francisco Javier Montero Fernández

2010-11-01

Full Text Available RESUMEN: Un número nuevo de una revista debe pensar una editorial, al igual que un proyecto necesita nacer de un argumento y un primer croquis para, inicialmente, ofrecer una imagen finalista. Después guardaremos la editorial en un cajón y desarrollaremos el número de la revista. Dentro de unos meses, sacaremos ese croquis y podremos reconocer su eficacia; sufrirá algún retoque pero esperamos que aún sea válido.Un viaje comienza con un empeño, un destino o una finalidad. Esta revista se ofrece en cada número con un carácter poliédrico acotando faceta a faceta, la definición de Arquitectura. Siempre que hablamos de ella intentamos conocerla, delimitarla y hay quien piensa que en su anatomía puede encerrarse el secreto de algo que es inaprensible. Paso a paso nos acercamos a su conocimiento lentamente, gracias a un esfuerzo parecido al del trabajo de Sísifo. Lo más acertado sería pensar que nuestro acercamiento es parecido al recorrido de una cinta de Moebius y aunque consigamos agotar el recorrido, siempre seremos conscientes de la breve e inasible distancia existente en el mismo punto de cada lado de la cinta. Este viaje que muchos quieren entender como absurdo, es el viaje de lo subjetivo, de aquello que nos permite acercarnos a las ideas para conocerlas poco a poco, lentamente, frente al eficaz conocimiento lógico, analítico, anatómico que, como el niño que desmonta los objetos, algunos investigadores intentan aplicar, desmontando los edificios, pensando que dentro están las ideas. No obstante todos se ven obligados a reconocer que ese trabajo sí que es absurdo porque nos lleva a la nada, quizás solo a la destrucción del pensamiento a favor del conocimiento ineficaz de la realidad.El otro conocimiento que proponemos consiste en una actitud alternativa, aquella que reivindica lo subjetivo frente a lo objetivo, para establecer como mecanismo de conocimiento una acotación del mundo que nos rodea, de los temas que nos

Estudio de la arquitectura y el nivel de desarrollo de la red LoRaWAN y de los dispositivos LoRa.

OpenAIRE

Ordóñez Monfort, Ignacio

2017-01-01

Es realitza un estudi sobre les diverses definicions del IoT que es concreta en una sèrie de requisits essencials del IoT i les característiques de les xarxes de connexió sobre les que sustentar-lo. Es realitza posteriorment un estudi en profunditat de les característiques de LoRA/LoRaWAN, que poden limitar o afavorir el seu ús com xarxa d'implementació del IoT, valorant de manera individualitzada cadascuna d'elles. Finalment, es realitza una analisi sobre el nivell de desenvolupament, madur...

LO INEFABLE: LENGUAJE Y REVELACIÓN

Directory of Open Access Journals (Sweden)

Emmanuel Taub

2012-07-01

Full Text Available Partiendo de la voz de Paul Valéry, Walter Benjamin y Gershom Scholem, estetrabajo intenta retomar la problemática de la redención y el lenguaje en la filosofía judíamoderna. Desde esta perspectiva se intenta pensar el problema de la redención como unproblema teológico-político que desde el lugar del lenguaje permite pensar lo divino frente alhombre, así como también aquello que hace al lugar de lo inefable: espacio de eternidad entreDios y el hombre.

Volcanic Activity on lo at the Time of the Ulysses Encounter.

Science.gov (United States)

Spencer, J R; Howell, R R; Clark, B E; Klassen, D R; O'connor, D

1992-09-11

The population of heavy ions in lo's torus is ultimately derived from lo volcanism. Groundbased infrared observations of lo between October 1991 and March 1992, contemporaneous with the 8 February 1992 Ulysses observations of the lo torus, show that volcanic thermal emission was at the low end of the normal range at all lo longitudes during this period. In particular, the dominant hot spot Loki was quiescent. Resolved images show that there were at least four hot spots on lo's Jupiter-facing hemisphere, including Loki and a long-lived spot on the leading hemisphere (Kanehekili), of comparable 3.5-micrometer brightness but higher temperature.

Lo Sport e le sue storie: l'esperienza aquilana, quando lo sport supera l'emergenza

Directory of Open Access Journals (Sweden)

Marco Pasini

2013-04-01

Full Text Available Tale progetto di ricerca, della durata di 12 mesi (da luglio 2010 a luglio 2011 e commissionato dal Ministero del Lavoro e delle Politiche Sociali , intende ricostruire il tessuto sociale di 400 giovani delle scuole secondarie di I e II livello de L’Aquila e provincia attraverso lo sport. Tessuto sociale leso e sfaldato in seguito all’evento sismico che il 6 aprile 2009 colpì il capoluogo abruzzese, in cui oltre all’improvvisa e immediata perdita di tutti i beni materiali sono venuti meno anche i canali di socializzazione primari e secondari. Una quotidianità da ricostruire anche e soprattutto attraverso il concetto di attività sportiva volta, in questo caso più che mai, alla realizzazione di cittadinanza, partecipazione, formazione umana, integrazione e coesione sociale. Con particolare attenzione agli sport di squadra che permettono uno sviluppo affettivo, cognitivo, relazionale e una maggiore comprensione/costruzione della propria personalità. Dunque lo sport come strumento principe per l’inclusione sociale, in quanto gioco che esalta l’armonia e le dinamiche di cooperazione. Lo sport, in generale, va considerato un fatto sociale; è un fenomeno sociale, un sistema culturale - che agisce tra comunicazione, economia e politica - e si presenta come una costruzione sociale. Costruzione generata da significati e rappresentazioni collettive.

El construccionismo y la cognición social: metáforas de la mente El construccionismo y la cognición social: metáforas de la mente

Directory of Open Access Journals (Sweden)

Eduardo Crespo Suárez

2003-01-01

Full Text Available Theories in the social and human sciences are always based on a model or metaphor of the human being. The main metaphors that have configurated the conception of the mind are the representational (the homunculus metaphor and the computational (the computer metaphor. Contructionism can be understood as a set of ideas articulated around the conception of the mind as a relationship and the conception of knowledge as a social construction. The metaphor of social construction implies that reality, as we know and live it, is not inevitable nor alien to responsibility. The questioning of the inevitability is basically made, from a constructionist point of view, in epistemological terms. Knowledge as an individual possesion is questioned. Inevitability, as it is approached by constructionists, is a palitical-type problem, related with the production of descriptions of the reality that oppear to us as obvious facts and then unquestionable. Social constructionism tries to function as a generative theory able to undermine the engagement with the predominant systems of theoretical production and to generate new options of action.Las teorías en las ciencias humanas y sociales, se constituyen siempre sobre un modelo o metáfora del ser humano. Las principales metáforas que han configurado la concepción de lo mente son las representacionistas (la metáfora del homúnculo y las computacionoles (la metáfora del ordenador. El construccionismo puede entenderse como un conjunto de ideas, articuladas en torno a la concepción de la mente como relación y el conocimiento como construcción sociaL La metáfora de la construcción social supone que la realidad, tal como la conocemos y la vivimos, no es ni inevitable ni ajena a la responsabilidad. El cuestionamiento de la inevitabilidad se hace, desde el construccionismo, en términos fundamentalmente epistemológicos. Se cuestiona la noción de conocimiento como propiedad individual. La inevitabilidad, tal como la

Metsämaisema ulkoilijoiden kokemana

OpenAIRE

Vuohijoki, Jaana

2010-01-01

Työn aiheena oli tutkia, miten ulkoilijat kokevat metsämaiseman Tampereella. Tavoitteena oli selvittää ulkoilijoiden maisema-arvostuksia sekä suhtautumista metsänhoidon toimenpiteisiin. Tutkimus toteutettiin maastohaastatteluina Tampereella kolmella eri asuinalueella: Hallilassa, Leinolassa ja Tesomajärvellä. Otoskooksi muodostui kymmenen haastattelua aluetta kohti, mutta yhdeltä vastaajalta ei ehditty kysyä kaikkia kysymyksiä. Vastaajat olivat yleisesti ottaen tyytyväisiä alueiden metsän...

El romanticismo como mito fundacional de lo joven

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Jairo Hernando Gómez Esteban

2009-01-01

Full Text Available El propósito principal de este ensayo es el de contribuir a la configuración y delimitación del corpus conceptual sobre juventud desde una perspectiva histórica, asumiendo el romanticismo como mito fundacional de lo joven, es decir, como el movimiento estético-político que ha logrado incrustarse y prevalecer no sólo en los imaginarios y rituales sino en las prácticas políticas y culturales de los jóvenes y las jóvenes de los dos últimos siglos. La hipótesis que me propongo demostrar es que las fuentes de las diversas formas de expresión ético-estéticas y políticas de la subjetividad contemporánea encarnadas en lo joven, no sólo se encuentran en el romanticismo, sino que siguen manifestándose con toda su fuerza y plenitud.

Mars MetNet Mission Status

Science.gov (United States)

Harri, A.-M.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.; Palin, M.; Nikkanen, T.

2015-10-01

New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semihard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

Lo profano en lo sagrado: Identidad religiosa y literaria en el Rāmāyaṇa

OpenAIRE

Figueroa Castro, Óscar

2014-01-01

Suele concebirse lo sagrado y lo profano como ámbitos distintos, incluso antagónicos. En la antigua cultura sánscrita muchos casos sugieren una interacción más complejo entre realidades sagradas y profanas. Aquí se explora el Rāmāyaṇa, una de las dos grandes épicas hinduistas. En especial, el artículo revisa la construcción, dentro del Rāmāyaṇa, de una identidad religioso-literaria frente al pasado védico y los valores de la ortodoxia brahmánica. Con este fin se analiza la tematización que el...

Chemistry technician performance evaluation program Palo Verde Nuclear Generating Station

International Nuclear Information System (INIS)

Shawver, J.M.

1992-01-01

The Arizona Nuclear Power Project (ANPP), a three-reactor site located 50 miles west of Phoenix, Arizona, has developed and implemented a program for evaluating individual chemistry technician analytical performance on a routine basis. About 45 chemistry technicians are employed at the site, 15 at each operating unit. The technicians routinely perform trace level analyses for impurities of concern to PWRs. Each month a set of blind samples is provided by an outside vendor. The blind samples contain 16 parameters which are matrixed to approximate the PWR's primary and secondary cycles. Nine technicians receive the samples, three from each operating unit, and perform the required analyses. Acceptance criteria for successful performance on the blind parameters is based on the values found in the Institute of Nuclear Power Operations (INPO) Document 83-016, Revision 2, August 1989, Chemistry Quality Control Program. The goal of the program is to have each technician demonstrate acceptable performance on each of 16 analytical parameters. On completion of each monthly set, a summary report of all of the analytical results for the sample set is prepared. From the summary report, analytical bias can be detected, technician performance is documented, and overall laboratory performance can be evaluated. The program has been very successful at satisfying the INPO requirement that the analytical performance of each individual technician should be checked on at least a six-month frequency for all important parameters measured. This paper describes the program as implemented at the Palo Verde Nuclear Generating Station and provides a summary report and trend and bias graphs for illustrative purposes

Word je met Donkey Konga een betere muzikant? : Muziek leren spelen met de spelcomputer

NARCIS (Netherlands)

Tom Langhorst

2010-01-01

Kan de spelcomputer behulpzaam zijn bij de ontwikkeling van het muzikale gevoel? Met die vraag in het achterhoofd bekijkt Tom Langhorst hier kritisch het Nintendo-spel Donkey Konga, waarin de speler mee kan drummen met bekende popsongs.

Mars MetNet Mission Status

Science.gov (United States)

Harri, Ari-Matti; Aleksashkin, Sergei; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Haukka, Harri

2015-04-01

New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Scientific Payload The payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: 1. MetBaro Pressure device 2. MetHumi Humidity device 3. MetTemp Temperature sensors Optical devices: 1. PanCam Panoramic 2. MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer 3. DS Dust sensor The descent processes dynamic properties are monitored by a special 3-axis accelerometer combined with a 3-axis gyrometer. The data will be sent via auxiliary beacon antenna throughout the

IP communication optimization for 6LoWPAN-Based Wireless Sensor Networks

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Li MA

2014-07-01

Full Text Available The emergence of 6LoWPAN makes it possible that Wireless Sensor Networks access to the Internet. However, the cost of IP communication between 6LoWPAN wireless sensor node and external internet node is still relatively high. This paper proposed a new addressing configuration and compression scheme in 6LoWPAN network called IPHC-NAT, which largely reduced the proportion of the IP header in 6LoWPAN packet, designed and constructed a bidirectional data transmission gateway to connect 6LoWPAN wireless sensor node with IPv6 client. The experimental results show the feasibility of the design of IPHC-NAT and the data transmission efficiency has significantly been improved compared to the original 6LoWPAN network.

Currents, temperature, conductivity, attenuation, and sigma-theta data from moorings deployed off the coast of Palos Verdes, CA from platforms VICKERS and ROBERT GORDON SPROUL from May 21, 1992 and March 30, 1993 (NODC Accession 0067573)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The sediments on the shelf off Palos Verdes CA are contaminated with large amounts of DDT. Moorings were deployed on the shelf in the winter of 1993 in part to...

Ad infinitum: implicaciones de lo sublime en la contemporaneidad

Directory of Open Access Journals (Sweden)

Miguel Ángel Gaete Cáceres

2014-12-01

Full Text Available El presente texto es un estudio que ofrece una revisión crítica al concepto de lo sublime basándose en la teorización clásica de esta idea, es decir, la adjudicada a Longino, Edmund Burke e Immanuel Kant. A partir de aquí, se intentará descubrir la presencia de lo sublime como un factor relevante en la configuración cultural del mundo contemporáneo, pasando por su presencia innegable en el arte de las vanguardias o en la concepción de la Naturaleza y el entorno. Finalmente, el objetivo central de este escrito es demostrar como lo sublime ofrece también una alternativa para comprender el problema de "lo infinito" y "lo ilimitado" en el marco de las tecnologías, la eclosión de las grandes ciudades y su filtración en el sustrato retórico del capitalismo, ofreciendo así una vía diferente en el estudio de este tema clásico de la estética.

Un viaje desde lo imaginario a lo real. Una aproximación al perfil del turista literario en España

Directory of Open Access Journals (Sweden)

Rubén J. Pérez Redondo

2017-05-01

Full Text Available Los viajes han sido frecuentemente objeto de inspiración para escritores y cronistas que han ido dejando la huella de su experiencia viajera en el desarrollo de sus textos. En ellos se suele alternar lo real con lo imaginario y es esa una de las principales fortalezas que puede tener un trabajo literario para alcanzar el éxito. La constante intromisión de lo real en lo ficticio y viceversa permite la construcción de incesantes imaginarios sociales en determinados lugares y momentos. Las creaciones literarias transportan al lector a una realidad que sólo existe o se configura en su cabeza. Con el auge y desarrollo del turismo literario, que es una rama del turismo cultural, se va a permitir, de múltiples maneras, que el lector complemente en el mundo real lo que experimentó en sus lecturas, por ejemplo visitando los lugares donde discurre la trama de una novela. En este artículo se va a analizar, por un lado, el turismo literario como factor de creación de nuevos imaginarios sociales y, por otra parte, se va a construir un perfil del turista literario en España que nos permita identificar cuáles son sus características comunes. Para conseguir este fin hemos revisado bibliografía específica sobre el tema tratado, se ha recurrido a organismos culturales que nos han aportado datos sobre el visitante y su experiencia viajera y hemos incorporado una encuesta como técnica para obtener información.      

LoRa Performance under Variable Interference and Heavy-Multipath Conditions

Directory of Open Access Journals (Sweden)

Kamil Staniec

2018-01-01

Full Text Available LoRa (or LoRaWAN is by far the best known representative of narrowband communication systems designed for the Internet of Things. As a system dedicated specifically for long-range operations, it possesses a considerable processing gain for the energetic link budget improvement and a remarkable immunity to multipath and interference. The paper describes outcomes of measurement campaigns during which the LoRa performance was tested against these two factors, that is, a heavy-multipath propagation and a controlled, variable interference generated, respectively, in a reverberation chamber and an anechoic chamber. Results allow quantitative appraisal of the system behavior under these harsh conditions with respect to LoRa’s three major configurable parameters: the spreading factor, bandwidth, and code rate. They also allow dividing LoRa configurational space into three distinct sensitivity regions: in the white region it is immune to both interference and multipath propagation, in the light-grey region it is only immune to the multipath phenomenon but sensitive to interference, and in the dark grey region LoRa is vulnerable to both phenomena.

Metástasis cutánea de carcinoma mamario: cáncer de mama en coraza. Revisión de la literatura y presentación de un caso

Directory of Open Access Journals (Sweden)

Lidia Torres Aja

2012-09-01

Full Text Available En la evolución clínica de los tumores malignos, entre el 1 y el 10,4 % de estos se presentan metástasis cutáneas, por lo que se considera su presencia sinónimo de enfermedad rápidamente progresiva con bajos índices de supervivencia. En los varones, el tumor que más suele producirlas es el de pulmón y en las mujeres, el de mama. Es poco frecuente que la metástasis en la piel sea la primera manifestación del tumor, y es el carcinoma de mama el que con mayor frecuencia da lugar a esta eventualidad. En el caso que se presenta fue la metástasis en la piel la primera manifestación del tumor primario de mama subyacente.

El análisis reticular de las metáforas sobre tecnociencia en inmigrantes : una propuesta teóricometodológica

OpenAIRE

Luna Hernández, Jesús René

2008-01-01

La inmigración es uno de los temas sociales más discutidos recientemente, tanto a favor como en contra. Sin embargo, en muchas ocasiones se deja de lado lo que los propios inmigrantes tienen que decir sobre la situación que viven. Uno de los aspectos menos estudiados es la relación interactiva/discursiva que los inmigrantes tienen con respecto a las nuevas tecnologías de información y comunicación (TICs). Presento una propuesta de estudio de las metáforas sobre tecnociencia que usan inmigrant...

PRECISION POINTING OF IBEX-Lo OBSERVATIONS

International Nuclear Information System (INIS)

Hłond, M.; Bzowski, M.; Möbius, E.; Kucharek, H.; Heirtzler, D.; Schwadron, N. A.; Neill, M. E. O'; Clark, G.; Crew, G. B.; Fuselier, S.; McComas, D. J.

2012-01-01

Post-launch boresight of the IBEX-Lo instrument on board the Interstellar Boundary Explorer (IBEX) is determined based on IBEX-Lo Star Sensor observations. Accurate information on the boresight of the neutral gas camera is essential for precise determination of interstellar gas flow parameters. Utilizing spin-phase information from the spacecraft attitude control system (ACS), positions of stars observed by the Star Sensor during two years of IBEX measurements were analyzed and compared with positions obtained from a star catalog. No statistically significant differences were observed beyond those expected from the pre-launch uncertainty in the Star Sensor mounting. Based on the star observations and their positions in the spacecraft reference system, pointing of the IBEX satellite spin axis was determined and compared with the pointing obtained from the ACS. Again, no statistically significant deviations were observed. We conclude that no systematic correction for boresight geometry is needed in the analysis of IBEX-Lo observations to determine neutral interstellar gas flow properties. A stack-up of uncertainties in attitude knowledge shows that the instantaneous IBEX-Lo pointing is determined to within ∼0. 0 1 in both spin angle and elevation using either the Star Sensor or the ACS. Further, the Star Sensor can be used to independently determine the spacecraft spin axis. Thus, Star Sensor data can be used reliably to correct the spin phase when the Star Tracker (used by the ACS) is disabled by bright objects in its field of view. The Star Sensor can also determine the spin axis during most orbits and thus provides redundancy for the Star Tracker.

Site surveillance and maintenance program for Palos Park: Report for 1987

International Nuclear Information System (INIS)

Golchert, N.W.

1988-04-01

The results of the environmental monitoring program conducted at Site A/Plot M in the Palos Park Forest Preserve area for CY 1987 are presented. The monitoring program is the ongoing remedial action that resulted from the original radiological characterization of the site. This study had determined that hydrogen-3 (as tritiated water) migrated from the burial ground and was present in two nearby hand-pumped picnic wells. The current program consists of sample collection and analysis of air, surface and subsurface water, and bottom sediment. The results of the analyses are used to (1) determine the migration pathway of water from the burial ground (Plot M) to hand-pumped picnic wells, (2) establish if buried radionuclides other than hydrogen-3 have migrated, and (3) generally characterize the radiological environment of the area. The program was designed to study the migration of non-radiological hazardous waste constituents that may have been buried with the radioactive waste. This was done by analyzing borehole water samples for selected heavy metals and organic compounds and analyzing quarterly water samples from the Red Gate Woods picnic well for inorganic constituents. Hydrogen-3 in the Red Gate Woods picnic well continued to show the same pattern of elevated levels in the winter and low concentrations in the summer, but the magnitude of the current winter peak was significantly less than in earlier years. 16 refs., 6 figs., 15 tabs

Radioactive waste isolation in salt: peer review of the Office of Nuclear Waste Isolation's report on the Organic Geochemistry of Deep Groundwaters from the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Fenster, D.F.; Brookins, D.G.; Harrison, W.; Seitz, M.G.; Lerman, A.; Stamoudis, V.C.

1984-08-01

This report summarizes Argonne's review of the Office of Nuclear Waste Isolation's (ONWI's) final report entitled The Organic Geochemistry of Deep Ground Waters from the Palo Duro Basin, Texas, dated September 1983. Recommendations are made for improving the ONWI report. The main recommendation is to make the text consistent with the title and with the objective of the project as stated in the introduction. Three alternatives are suggested to accomplish this

Lo sagrado en las sociedades secularizadas

Directory of Open Access Journals (Sweden)

González Noriega, Santiago

1993-10-01

Full Text Available Not available.

La potencia tutelar burocrática asume la custodia de una masa amorfa. Frente a ella ha de afirmarse una sociedad civil a partir de núcleos de ciudadanos activos. El motor de esta ciudadanía es la formación de un núcleo básico de creencias -«lo sagrados-e- que desempeña un papel comparable, en cuanto a capacidad de movilización, al de las viejas religiones. Lo sagrado «laico» o «filosófico» apunta a aquello que el hombre puede considerar perdurable y conferir sentido a su existencia.

La ley del reloj. Orígenes de la metáfora de la máquina en la arquitectura

Directory of Open Access Journals (Sweden)

Eduardo Prieto

2015-07-01

Full Text Available Los edificios no son máquinas. No lo son, desde luego, si se sigue la definición que da de ellas el Essai sur la composition des machines, el excelente manual publicado en 1808 por dos ingenieros españoles, Betancourt y Lanz, y que fue el primero de su género (Betancourt, 1808:5. Allí las máquinas se presentan como objetos que sirven para dirigir y regular una fuerza o, dicho con mayor sencillez, para producir un movimiento. A nadie se le oculta, sin embargo, que en la arquitectura no hay movimiento, y si lo hay es en un mero sentido figurado, como cuando se tratan los edificios como canales que distribuyen flujos o se incide en su capacidad para transformarse, o como cuando, simplemente, se pone el énfasis en los artefactos movibles que forman parte de ellos. En realidad, la distancia entre las máquinas y los edificios es tan grande que solo puede salvarse con metáforas impropias, pues ni la arquitectura se mueve ni las máquinas se habitan. Sin embargo, las máquinas no han dejado de tratarse como objetos análogos a los edificios y han mesmerizado a los arquitectos, que han creído ver en ellas no solo metáforas, sino modelos rigurosos de organización, cuando no objetos sublimes dignos de imitarse. ¿Qué explica su presencia recurrente en la teoría de la arquitectura de los últimos tres siglos?

GERENCIAR Y GESTIONAR LO CULTURAL TAREA INAPLAZABLE

OpenAIRE

Martha Isabel Tovar

2013-01-01

Este artículo aborda lo concerniente a la formación de Gerentes y Gestores Culturales como actores principales de la gestión cultural. Para ello examinará los entornos o escenarios donde lo cultural se manifiesta como reflejo de los contextos sociales en los cuales se trabaja la cultura. El artículo termina mostrando cómo los elementos de la gerencia social son una alternativa en la formación de gerentes y gestores sociales.

GERENCIAR Y GESTIONAR LO CULTURAL TAREA INAPLAZABLE

Directory of Open Access Journals (Sweden)

Martha Isabel Tovar

2013-07-01

Full Text Available Este artículo aborda lo concerniente a la formación de Gerentes y Gestores Culturales como actores principales de la gestión cultural. Para ello examinará los entornos o escenarios donde lo cultural se manifiesta como reflejo de los contextos sociales en los cuales se trabaja la cultura. El artículo termina mostrando cómo los elementos de la gerencia social son una alternativa en la formación de gerentes y gestores sociales.

De lo invisible y lo cotidiano. Familias y discapacidad

Directory of Open Access Journals (Sweden)

Araya Umaña, Sandra

2007-12-01

Full Text Available Resumen: La construcción social de la realidad comporta un pensamiento dicotómico que asocia la discapacidad con el par normal – anormal lo que favorece procesos de exclusión social de las personas con discapacidad y sus familias. A su vez, el concepto de familia se finca en un modelo construido social y culturalmente que privilegia la subordinación de otras formas de organización familiar pues este modelo es el que se considera normal.Tanto el concepto de familia como el de discapacidad contienen una carga ideológica cuya pretensión es la prescripción y con ella lo que se favorece es la proscripción. A partir de la teoría de las representaciones sociales, este artículo aborda las dinámicas que surgen de la vinculación de ambos conceptos con el fin de evidenciar los caminos recorridos y los que aun falta recorrer para el logro de una sociedad inclusiva.Abstract: The social construction of reality involves a dichotomizing thinking that associates the discapacity with the normal pair - abnormal which favors processes of social exclusion for people with discapacity, as well as their families.Also, the concept of family is based on a model constructed socially and culturally that favors the subordination of other forms of family organizations, as that model is the one considered normal.Family and discapacity concepts, holds an ideological burden whose pretension is the prescription, which will encourage the proscription.Based on the theory of socials representations, this article deals with the dynamics that emerge from the linkage of the two concepts in order to demonstrate the roads and paths that lack even go to the achievement of an inclusive society.

Phase I Trial of Anti-MET Monoclonal Antibody in MET-Overexpressed Refractory Cancer.

Science.gov (United States)

Lee, Jeeyun; Kim, Seung Tae; Park, Sungju; Lee, Sujin; Park, Se Hoon; Park, Joon Oh; Lim, Ho Yeong; Ahn, Hongmo; Bok, Haesook; Kim, Kyoung-Mee; Ahn, Myung Ju; Kang, Won Ki; Park, Young Suk

2018-06-01

Samsung Advance Institute of Technology-301 (SAIT301) is a human immunoglobulin G2 antibody that can specifically target mesenchymal epithelial transition factor (c-MET). This novel antibody has higher priority over hepatocyte growth factors when binding to the Sema domain of c-MET and accelerates the internalization and degradation of c-MET, proving its powerful antitumor activities in intra- as well as extracellular areas. SAIT301 was administered intravenously once every 3 weeks in c-MET overexpressed solid tumor patients, focusing on metastatic colorectal cancer (CRC) according to common clinical phase I criteria. Dose escalation was performed according to a modified Fibonacci design, following the conventional 3+3 design. The purpose of this phase I study was to assess the safety profile, to establish the recommended dose for clinical phase II studies and to assess potential anticancer activity of the compound. Sixteen patients with a median age of 56 (range, 39-69) years were enrolled in the study. The most common adverse events were decreased appetite (50.0%), hypophosphatemia, fatigue and dizziness (25.0%, respectively), and diarrhea, blood alkaline phosphatase increased and dyspnea (18.8%, respectively). For tumor response, no patients achieved complete response. One (9.1%) CRC patient had a partial response in the 1.23 mg/kg group, 4 (36.4%) patients achieved stable disease (2 in the 0.41 mg/kg group, 2 in the 1.23 mg/kg group, 0 in the 3.69 mg/kg group, and 1 in the 8.61 mg/kg group). Because of the increase in dose-limiting toxicities (DLTs) at 8.61 mg/kg, the 3.69 mg/kg dose was considered the maximum tolerated dose and selected for further assessment in phase II. We successfully completed a phase I trial with MET antibody in a MET-overexpressed patient population focusing on CRC, and found that the DLTs were alkaline phosphatase elevation or hypophosphatemia. The recommended dose of SAIT301 for phase II is the dose of 3.69 mg/kg. Copyright © 2018

Ambient noise tomography of Lo'ihi

Science.gov (United States)

McClement, K.; Thurber, C. H.; Teel, A.; Caplan-Auerbach, J.

2012-12-01

Lo'ihi seamount, the youngest volcano in the Hawaiian-Emperor chain, lies approximately 30 km south of Hawai'i Island with its summit still approximately 1 km below sea level. Lo'ihi offers a unique opportunity to study the early formation of a hotspot volcano and can provide insight into the deep internal structure of the other volcanoes that make up the Hawaiian Islands. This study uses Ambient Noise Tomography (ANT) to create a 3D tomographic image of Lo'ihi's S-wave velocity structure from ocean bottom seismometer (OBS) data. ANT has been used in many subaerial studies but has seen very few applications to OBS data. This study uses continuous data recorded in 2010 to 2011 from 12 short-period OBS instruments deployed on and around Lo'ihi. With the farthest distance between stations being just over 30 km, the stations provide a fairly dense coverage mainly for the northern half of the volcano. Following the approach of Masterlark et al. [2010], we computed vertical-vertical and vertical-radial cross-correlations using 97 days of continuous data from the 12 stations to produce the ambient noise Green's functions. From these, dispersion curves were produced over a frequency range from .04 Hz to 0.65 Hz . After a quality control analysis, checkerboard tests were used to determine a suitable cell size for the 2D group velocity inversions. The final step is the inversion of the group velocity dispersion curves to create a 3D Vs model. The 3D Vs image produced through this method does not provide clear evidence of a shallow magma chamber; however, when compared to a previous P-wave velocity (Vp) model [Caplan-Auerbach, 2001], a high Vp/Vs ratio is evident especially at depths from 1 km to 5 km, indicating the presence of highly fractured rock.

Microbewerking met behulp van lasers

NARCIS (Netherlands)

Ezendam, M.M.M.

1994-01-01

Het bewerken van materialen met behulp van lasers staat momenteel enorm in de belangstelling, en terecht. De ontwikkeling van bestaande en nieuwe typen lasers staat alles behalve stil. Ontwikkelingen bevinden zich met name in het gebied van hogere vermogens, betere bundelkwaliteit en hogere

La dinámica de lo femenino y lo masculino en la psicología analítica junguiana

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Fabio Andrés Ramírez Gómez

2014-01-01

Full Text Available El presente artículo pretende mostrar, a la luz de la psicología de orientación junguiana, cómo se concibe lo femenino y lo masculino en el psiquismo humano, para lo cual se abordan los elementos conceptuales más significativos de dicha teoría, en donde se hace una minuciosa diferenciación entre los diferentes niveles psíquicos. A partir de allí se distinguen las características, el dinamismo y la influencia, tanto colectiva e individual que tiene la simbología femenino/masculino y la importancia que de allí se desprende para un abordaje terapéutico. Con la riqueza de los elementos que aporta esta perspectiva, este artículo pretende servir como un referente conceptual para sustentar, a mediano plazo, un modelo de intervención en el ámbito grupal, familiar y de pareja.

MMPM - Mars MetNet Precursor Mission

Science.gov (United States)

Harri, A.-M.; Schmidt, W.; Pichkhadze, K.; Linkin, V.; Vazquez, L.; Uspensky, M.; Polkko, J.; Genzer, M.; Lipatov, A.; Guerrero, H.; Alexashkin, S.; Haukka, H.; Savijarvi, H.; Kauhanen, J.

2008-09-01

We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. Prototyping of the payload instrumentation with final dimensions was carried out in 2003-2006.This huge development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development. To understand the behavior and dynamics of the Martian atmosphere, a wealth of simultaneous in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes. This will be performed by the Mars MetNet Mission. In addition to the science aspects the

MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor.

Science.gov (United States)

Togashi, Yosuke; Mizuuchi, Hiroshi; Tomida, Shuta; Terashima, Masato; Hayashi, Hidetoshi; Nishio, Kazuto; Mitsudomi, Tetsuya

2015-12-01

MET splice site mutations resulting in an exon 14 deletion have been reported to be present in about 3% of all lung adenocarcinomas. Patients with lung adenocarcinoma and a MET splice site mutation who have responded to MET inhibitors have been reported. The CRISPR/Cas9 system is a recently developed genome-engineering tool that can easily and rapidly cause small insertions or deletions. We created an in vitro model for MET exon 14 deletion using the CRISPR/Cas9 system and the HEK293 cell line. The phenotype, which included MET inhibitor sensitivity, was then investigated in vitro. Additionally, MET splice site mutations were analyzed in several cancers included in The Cancer Genome Atlas (TCGA) dataset. An HEK293 cell line with a MET exon 14 deletion was easily and rapidly created; this cell line had a higher MET protein expression level, enhanced MET phosphorylation, and prolonged MET activation. In addition, a direct comparison of phenotypes using this system demonstrated enhanced cellular growth, colony formation, and MET inhibitor sensitivity. In the TCGA dataset, lung adenocarcinomas had the highest incidence of MET exon 14 deletions, while other cancers rarely carried such mutations. Approximately 10% of the lung adenocarcinoma samples without any of driver gene alterations carried the MET exon 14 deletion. These findings suggested that this system may be useful for experiments requiring the creation of specific mutations, and the present experimental findings encourage the development of MET-targeted therapy against lung cancer carrying the MET exon 14 deletion. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

La metáfora geométrica en la música: una transferencia de experiencias de pensamiento entre dos disciplinas

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Myriam Arroyave

2012-09-01

Full Text Available Este texto elabora, por medio de una metáfora geométrica, una transferencia de experiencias de pensamiento entre geometría y música. La metáfora permite la construcción del espacio gráfico y la elaboración conceptual de la música occidental. Con el sistema de líneas y puntos de la notación diastemática, algunos principios de la construcción geométrica —orden, proporción, periodicidad— devienen el motor del razonamiento musical. El problema fundamental que plantea el desarrollo de esta escritura es la construcción racional del tiempo musical. La metáfora geométrica abre un campo de transiciones conceptuales en música, el cual materializa el pasaje del registro auditivo al registro visual. La competencia entre ojo y oído genera conflictos de temporalidad y de espacialidad. Lo geométrico se convierte en un género particular de articulación del espacio y del tiempo en música. La praxis de un pensamiento que se despliega en el dominio de las formas espacio-temporales se manifiesta en el sistema escrito de la música tradicional occidental.

Using blockchain to build trusted LoRaWAN sharing server

Directory of Open Access Journals (Sweden)

Jun Lin

2017-09-01

Full Text Available Purpose – With the rapid growth of the Internet of Things (IoT market and requirement, low power wide area (LPWA technologies have become popular. In various LPWA technologies, Narrow Band IoT (NB-IoT and long range (LoRa are two main leading competitive technologies. Compared with NB-IoT networks, which are mainly built and managed by mobile network operators, LoRa wide area networks (LoRaWAN are mainly operated by private companies or organizations, which suggests two issues: trust of the private network operators and lack of network coverage. This study aims to propose a conceptual architecture design of a blockchain built-in solution for LoRaWAN network servers to solve these two issues for LoRaWAN IoT solution. Design/methodology/approach – The study proposed modeling, model analysis and architecture design. Findings – The proposed solution uses the blockchain technology to build an open, trusted, decentralized and tamper-proof system, which provides the indisputable mechanism to verify that the data of a transaction has existed at a specific time in the network. Originality/value – To the best of our knowledge, this is the first work that integrates blockchain technology and LoRaWAN IoT technology.

Evolution of Starspots on LO Pegasi

Science.gov (United States)

Harmon, Robert; Bloodgood, Felise; Martin, Alec; Pellegrin, Kyle

2018-01-01

LO Pegasi is a young solar analog, a K main-sequence star that rotates with a period of 10.1538 hr. The rapid rotation yields a strong stellar dynamo associated with large starspots on the surface, which are regions where the magnetic field inhibits the convective transport of energy from below, so that the spots are cooler and thus darker than the surrounding photosphere. The star thus exhibits rotational modulation of its light curve as the starspots are carried into and out of view of Earth. CCD images of LO Peg were acquired at Perkins Observatory in Delaware, OH through standard B, V, R, and I photometric filters from 2017 June 1 to July 20. After subtracting dark frames and flat fielding the images, differential aperture photometry was performed to yield light curves through each of the four filters. The resulting light curves that were then analyzed via the Light-curve Inversion program created by one of us (Harmon) to produce surface maps. Our observations indicated that LO Pegasi’s light curve changed in both amplitude and shape between 2017 June and July, while its maximum brightness did not change. We present maps corresponding to these two distinct light curves, along with maps for data acquired from 2006-2016.

Fusión vs. cultura organizacional. Lo real y lo virtual

Directory of Open Access Journals (Sweden)

William Castillo

2004-01-01

Full Text Available Las organizaciones en las ultimas decadas han presenciado el cambio de concepcion sobre lo que se desean alcanzar dentro del mundo de los negocios, donde se promueven movimientos radicales, estos traen consigo oportunidades y riesgo por enfrentar. Una de las premisas basicas sobre este topico es el desenvolvimiento de las organizaciones en un mercado globalizado, enfrentadas en conflictos internos y externos, generando ademas una variacion en la estrcutura organizacional, cultura empresarial y en la toma de decisiones sobre las estrategias para adaptarse al cambio.

Pumping test and fluid sampling report, Mansfield No. 1 well, Palo Duro Basin: Report of the Geologic Project Manager, Permian Basin

Energy Technology Data Exchange (ETDEWEB)

1983-07-01

This report describes pumping test and fluid sampling activities performed at the Mansfield No. 1 well in Oldham County about 10 miles north of Vega, Texas. The well site was selected by TBEG and is located along the northern margin of the Palo Duro Basin in an area of active dissolution with the Permian salt sections. The objectives of the pumping test and fluid sampling program were to collect data to determine the hydrologic characteristics (formation pressure and permeability) of deep water bearing formations, and to obtain formation fluid samples for analyses (gas and fluid chemistry) in order to evaluate fluid migration and age relationships in the Permian Basin. 4 refs., 8 figs., 2 tabs.

Pumping test and fluid sampling report, Mansfield No. 1 well, Palo Duro Basin: Report of the Geologic Project Manager, Permian Basin

International Nuclear Information System (INIS)

1983-07-01

This report describes pumping test and fluid sampling activities performed at the Mansfield No. 1 well in Oldham County about 10 miles north of Vega, Texas. The well site was selected by TBEG and is located along the northern margin of the Palo Duro Basin in an area of active dissolution with the Permian salt sections. The objectives of the pumping test and fluid sampling program were to collect data to determine the hydrologic characteristics (formation pressure and permeability) of deep water bearing formations, and to obtain formation fluid samples for analyses (gas and fluid chemistry) in order to evaluate fluid migration and age relationships in the Permian Basin. 4 refs., 8 figs., 2 tabs

Lo sport come filosofia educativa e sociale: una prospettiva decostruzionista

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Emanuele Isidori

2013-04-01

Full Text Available Lo scopo del presente articolo è quello di procedere, utilizzando un approccio filosofico decostruzionista, ad una disamina dello sport come oggetto filosofico, mostrandone le contraddizioni interne, i paradossi e le aporie che lo caratterizzano in quanto concetto educativo-culturale e fenomeno sociale. L’analisi si svilupperà riflettendo su tre temi tipici del dibattito decostruzionista: quello del phármakon, dell’identità e dell’ospitalità, tema quest’ultimo tipico anche del pensiero debole che presenta forti interconnessioni con il pensiero decostruzionista e postmoderno. Lo studio, che utilizzerà il tipico approccio teoretico-prassico della filosofia dell’educazione, evidenzierà sia i meccanismi concettuali che talvolta impediscono allo sport di essere pensato come pratica realmente educativa ed in grado di generare l’inclusione sociale, sia quelli che invece ne permettono la teorizzazione e l’implementazione in questa prospettiva. Lo studio si concluderà mostrando come per concepire realmente lo sport nella prospettiva di un autentico strumento educativo e di miglioramento della vita sociale sia necessaria una vera e propria rivoluzione etica e culturale della nostra società. Lo sport, infatti, in quanto sottosistema della società, rappresenta lo specchio dei valori di quest’ultima e non solo ne incarna i difetti, le contraddizioni ma anche le sue buone prassi. Questa rivoluzione deve necessariamente passare attraverso l’educazione; soltanto così, infatti, sarà possibile costruire quella società nuova, fondata sulla paidéia sportiva, che De Coubertin sognava per l’umanità futura.

Currents, wind speed, wind direction, temperature, attenuation, conductivity, and sigma-theta data from moorings deployed off the coast of Palos Verdes, CA from platforms ROBERT GORDON SPROUL, SEAWATCH, and YELLOWFIN from February 15, 2004 to July 8, 2004 (NODC Accession 0067574)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Palos Verdes shelf near Los Angeles is contaminated with DDT and PCBs discharged through the White Point ocean outfalls, mostly prior to 1971. The U. S....

Currents, temperature, conductivity, attenuation, sigma-theta, and wave statistics data from moorings deployed off the coast of Palos Verdes, CA from platforms ROBERT GORDON SPROUL, YELLOWFIN, and SEA WATCH from December 3, 2007 to April 29, 2008 (NODC Accession 0067575)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Palos Verdes shelf near Los Angeles is contaminated with DDT and PCBs discharged through the White Point ocean outfalls, mostly prior to 1971. The U. S....

Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.

Science.gov (United States)

Dodds, Chris M; Henson, Richard N; Suckling, John; Miskowiak, Kamilla W; Ooi, Cinly; Tait, Roger; Soltesz, Fruzsina; Lawrence, Phil; Bentley, Graham; Maltby, Kay; Skeggs, Andrew; Miller, Sam R; McHugh, Simon; Bullmore, Edward T; Nathan, Pradeep J

2013-01-01

It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results suggest that the BDNF Val66Met polymorphism does not, as previously claimed, exert an observable effect on neural systems underlying encoding of new information into episodic memory but may exert a subtle effect on the efficiency with which such information can be retrieved.

Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.

Directory of Open Access Journals (Sweden)

Chris M Dodds

Full Text Available It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results suggest that the BDNF Val66Met polymorphism does not, as previously claimed, exert an observable effect on neural systems underlying encoding of new information into episodic memory but may exert a subtle effect on the efficiency with which such information can be retrieved.

Superposición de Subjetividades: La ciudad y lo virtual

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Evelyn Alonso Rohner

2017-04-01

Full Text Available Las nuevas cartografías urbanas, que identifican –a veces en tiempo real– la localización de nuevas actividades y recorridos, y que parecen pertenecer en sus atractivas representaciones al más puro estado de lo gaseoso, manifiestan cambios de emplazamiento efectivos respecto a lo previsible. Esta mutabilidad continua de los flujos y las localizaciones, deriva en inevitables readaptaciones de la ciudad real. No solo por las nuevas “lecturas” que de la misma hacemos, y de los nuevos mapas que construimos, sino por la necesaria adaptación de sus estructuras, que pasarán a ser determinadas, no por lo fuerte –trazados e infraestructuras– sino precisamente por lo débil e invisible de la información virtual. No es algo nuevo; los libros de viaje y los planos también modificaron la construcción, primero mental y luego física, de la ciudad. Pero la nueva cartografía constituida por la superposición de subjetividades de millones de ciudadanos, muestran ya la transformación de la ciudad real, y lo hacen a velocidades inimaginables antes, transformando lo estático en dinámico, y forzando a su consideración activa en cualquier futura decisión que afecte al planeamiento y el proyecto urbano.

Lo orgánico y lo funcional en psiquiatría

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Roberto Anselmo Ramos Valverde

2014-08-01

Full Text Available El desarrollo acelerado de las neurociencias en las últimas dos décadas permitió rescatar al cerebro de las sombras cartesianas donde se encontraba condenado, demostrándose que todo fenómeno psíquico, normal o morboso, tiene como sustento material a este órgano gestor de las funciones psíquicas. De esta manera quedó esclarecido que los trastornos mentales desencadenados por acontecimientos psicosociales estresantes actúan sobre el cerebro, provocando cambios neuroquímicos a nivel molecular responsables de la sintomatología que los tipifica, conjugándose etiopatogénicamente los factores biológicos, psicológicos y sociales gestores de estos desórdenes mentales. (1 Se distinguen en psiquiatría dos tipos de perfiles clínicos que los clásicos semiólogos clasificaron en síndromes orgánicos y funcionales; los primeros causados por alteraciones estructurales a nivel histopatológico en el cerebro o sus envolturas, nombradas afecciones orgánicas propiamente dichas, y síntomáticas cuando afectan el metabolismo cerebral a distancia; los segundos sustentan los cambios a nivel molecular, afectando la constitución química del cerebro por factores psicosociales, hereditarios y congénitos. (1 Los avances neurobiológicos esclarecen la multicausalidad de los trastornos mentales y el papel organogénico del cerebro, sustentado en su capacidad intrínseca de reflejar la realidad objetiva, que al perderse origina el espectro psicopatológico que hoy conocemos. (2 Algunos autores contemporáneos a partir del resurgimiento del protagonismo cerebral en la cristalización de los trastornos mentales, plantean que las fronteras entre lo orgánico y lo funcional se quebraron y que la enfermedad mental es orgánica en toda su extensión dada la obligada participación etiológica del cerebro. Soy del criterio que la actual omnipresencia cerebral en la generación de los procesos psicológicos, es sin duda, una virtud trascendente de la ciencia

Gezondheidsrisico's in verband met het werken met Polychloorbifenylen : een onderzoek

NARCIS (Netherlands)

Geuskens, R.B.M.; Nossent, S.M.; Koëter, H.B.W.M.; Dreef-van der Meulen, H.C.; Stijkel, A.; Zielhuis, R.L.

1989-01-01

Met behulp van gegevens verkregen uit een werkplekinventarisatie naar gegevens over produktie/gebruik, risicopopulatie en (mogelijke) blootstelling aan polychloorbifenylen (PCB's), en een literatuurstudie naar mogelijke schadelijke eigenschappen van PCB's op het reproductiesysteem en/of nageslacht

The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma.

Directory of Open Access Journals (Sweden)

Steven N Steinway

Full Text Available c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF, plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC patients with activated HGF/c-Met signaling have a significantly worse prognosis. Targeted therapies using c-Met tyrosine kinase inhibitors are currently in clinical trials for HCC, although receptor tyrosine kinase inhibition in other cancers has demonstrated early success. Unfortunately, therapeutic effect is frequently not durable due to acquired resistance.We utilized the human MHCC97-H c-Met positive (c-Met+ HCC cell line to explore the compensatory survival mechanisms that are acquired after c-Met inhibition. MHCC97-H cells with stable c-Met knockdown (MHCC97-H c-Met KD cells were generated using a c-Met shRNA vector with puromycin selection and stably transfected scrambled shRNA as a control. Gene expression profiling was conducted, and protein expression was analyzed to characterize MHCC97-H cells after blockade of the c-Met oncogene. A high-throughput siRNA screen was performed to find putative compensatory survival proteins, which could drive HCC growth in the absence of c-Met. Findings from this screen were validated through subsequent analyses.We have previously demonstrated that treatment of MHCC97-H cells with a c-Met inhibitor, PHA665752, results in stasis of tumor growth in vivo. MHCC97-H c-Met KD cells demonstrate slower growth kinetics, similar to c-Met inhibitor treated tumors. Using gene expression profiling and siRNA screening against 873 kinases and phosphatases, we identified ErbB3 and TGF-α as compensatory survival factors that are upregulated after c-Met inhibition. Suppressing these factors in c-Met KD MHCC97-H cells suppresses tumor growth in vitro. In addition, we found that the PI3K/Akt signaling pathway serves as a negative feedback signal responsible for the ErbB3 upregulation after c-Met inhibition. Furthermore, in vitro studies demonstrate that

La reinvención de lo público en la videocultura urbana

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Néstor García Canclini

2002-01-01

Full Text Available ¿Se puede reconstruir lo público en una megalópolis donde lo privado invade todo, donde las reglas se reemplazan por el caos o por la simulación del control de quienes nos informan y vigilan? A partir de drásticos cambios producidos en la familia tradicional, la ciudad y el Estado-nación, se intenta replantear la definición de lo público en el nuevo tipo de experiencias urbanas establecidas por las megaciudades y los medios masivos de comunicación. Los medios electrónicos lo buscan construyendo imaginarios que articulan lo global y lo local así como en la visualidad publicitaria urbana, a través de la espectacularización de mercancías y servicios, incluidos aquellos a los que sólo acceden minorías. Esto lleva a evaluar en qué medida los medios cumplen una función pragmática o más bien una función simbólica y ritual.

MET Expression in Primary and Metastatic Clear Cell Renal Cell Carcinoma: Implications of Correlative Biomarker Assessment to MET Pathway Inhibitors

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Brian Shuch

2015-01-01

Full Text Available Aims. Inhibitors of the MET pathway hold promise in the treatment for metastatic kidney cancer. Assessment of predictive biomarkers may be necessary for appropriate patient selection. Understanding MET expression in metastases and the correlation to the primary site is important, as distant tissue is not always available. Methods and Results. MET immunofluorescence was performed using automated quantitative analysis and a tissue microarray containing matched nephrectomy and distant metastatic sites from 34 patients with clear cell renal cell carcinoma. Correlations between MET expressions in matched primary and metastatic sites and the extent of heterogeneity were calculated. The mean expression of MET was not significantly different between primary tumors when compared to metastases (P=0.1. MET expression weakly correlated between primary and matched metastatic sites (R=0.5 and a number of cases exhibited very high levels of discordance between these tumors. Heterogeneity within nephrectomy specimens compared to the paired metastatic tissues was not significantly different (P=0.39. Conclusions. We found that MET expression is not significantly different in primary tumors than metastatic sites and only weakly correlates between matched sites. Moderate concordance of MET expression and significant expression heterogeneity may be a barrier to the development of predictive biomarkers using MET targeting agents.

COMT (Val158Met and BDNF (Val66Met Genes Polymorphism in Schizophrenia: A Case-Control Report

Directory of Open Access Journals (Sweden)

ramin saravani

2017-10-01

Full Text Available Objective: The effects of human brain-derived neurotropic factor (BDNF Val66Met (G>A and the human Catechol-O-methylTransferase (COMT Val158Met (G>A polymorphisms on Schizophrenia (SCZ risk were evaluated.Methods: This case control study included 92 SCZ patients and 92 healthy controls (HCs. Genotyping of both variants were conducted using Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR.Results: The findings showed that BDNF Val66Met (G>A variant increased the risk of SCZ (OR=2.008 95%CI=1.008-4.00, P=0.047, GA vs. GG, OR=3.876 95%CI=1.001-14.925, P=0.049. AA vs. GG, OR=2.272. 95%CI=1.204-4.347, P=0.011, GA+AA vs. GG, OR=2.22 95%CI=1.29-3.82. P=0.005, A vs. G. COMT Val158Met (G>A polymorphism was not associated with the risk/protective of SCZ.Conclusion: The results proposed that BDNF Val66Met (G>A polymorphism may increase the risk of SCZ development and did not support an association between COMT Val158Met (G>A variant and risk/protective of SCZ. Further studies and different ethnicities are recommended to confirm the findings.

Lo-Dash essentials

CERN Document Server

Boduch, Adam

2015-01-01

If you are a curious JavaScript developer interested simultaneously in tweaking the efficiency of your code, as well as improving the conciseness of it, and maintaining the readability of it, then this is the book for you. Ideally, the book is intended for readers already working on JavaScript projects and using frameworks such as jQuery and Backbone. Even if you're already using Lo-Dash, this book will show you how to use it efficiently. While extensive JavaScript experience isn't a requirement, you should have at least some prior programming experience in order to best understand the concept

Mars MetNet Precursor Mission Status

Science.gov (United States)

Harri, A.-M.; Aleksashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.

2013-09-01

We are developing a new kind of planetary exploration mission for Mars in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

Route-Over Forwarding Techniques in a 6LoWPAN

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Andreas Weigel

2014-12-01

Full Text Available 6LoWPAN plays a major role within the protocol stack for the future Internet of Things. Its fragmentation mechanism enables transport of IPv6 datagrams with the required minimum MTU of 1280 bytes over 802.15.4-based networks. With the goal of a fully standardized WSN protocol stack currently necessitating a route-over approach, i.e., routing at the IP-layer, there are two main choices for any 6LoWPAN implementation with regard to datagram fragmentation: Hop-by-hop assembly or a cross-layered direct mode, which forwards individual 6LoWPAN fragments before the whole datagram has arrived. In addition to these two straightforward approaches, we propose enhancements based on adaptive rate-restriction for the direct forwarding and a retry control for both modes to reduce the number of losses of larger datagrams. An evaluation of these modes in a simulation environment and a hardware testbed indicate that the proposed enhancements can considerably improve PRR and latency within 6LoWPAN networks.

Historia reciente del trabajo y los trabajadores. Apuntes sobre lo tradicional y lo nuevo, lo que cambia y permanece en el mundo del trabajo

Directory of Open Access Journals (Sweden)

Roxana Albanesi

2015-07-01

Full Text Available Referirse al trabajo es hacer mención a un concepto complejo y multifacético. A su vez, los trabajadores constituyen un grupo social heterogéneo cuya ubicación en la estructura social es diversa. En este artículo se buscar reflexionar acerca de las características actuales del trabajo. Se presenta una breve reseña histórica que remite a las diferentes formas que asume la relación capital-trabajo en el tiempo para detenerse, con mayor profundidad, en las transformaciones ocurridas desde la crisis del capitalismo industrial hasta nuestros días. La reflexión acerca de lo que cambió y lo que permanece como tendencias en el mundo del trabajo depende de la periodización con que se aborde la cuestión. La evolución general del capitalismo muestra que la informalidad, la precariedad, la inestabilidad son condiciones clásicas del trabajo cuando se encuentra sujeto a mercados autorregulados. Las diferencias quedan claramente identificadas cuando se toma como referencia el período del Estado de Bienestar. Desde esta perspectiva temporal, la desigualdad de los ingresos entre diferentes ramas y al interior de un mismo grupo no constituye una novedad, pero sí lo son la degradación de las condiciones de trabajo y la desprotección social. En la historia reciente, esta situación es percibida por los trabajadores como un incremento de la vulnerabilidad y de los riesgos. El desempleo como realidad o como amenaza permanente, las condiciones flexibles del trabajo, el debilitamiento de la creencia en soluciones colectivas, la resignación social, la organización de estrategias individuales e individualistas, son rasgos distintivos de la historia reciente de los trabajadores.

Ülo Isberg : Tahtsin midagi Eesti heaks teha / Riho Laurisaar

Index Scriptorium Estoniae

Laurisaar, Riho

2005-01-01

14. juunil sõitis koos Estpla-11 kergejalaväerühmaga Iraaki koalitsioonivägede (Multinational Corps-Iraq) teavitusosakonna teenistusse reservohvitser Ülo Isberg. Sõjaväeametniku elu- ja teenistuskäigust. Lisa: Ülo Isberg

Background radiation in two locations in Deaf Smith and Swisher Counties within the Palo Duro Basin

International Nuclear Information System (INIS)

1984-10-01

Data on external background radiation doses resulting from cosmic, terrestrial, and fallout sources and on concentrations of radioactivity in environmental media are presented and discussed. Doses to individuals located at the approximate centers of two locations in Texas, one in Deaf Smith County and the other in Swisher County, are given, as are the population doses to people residing within 50 miles of each of the approximate centers. No adjustments have been made for the effects of buildings on radiation doses - that is, the shielding from external radiation afforded by the buildings and radiation from building materials are not accounted for. Concentrations of radioactivity in air, water, and milk in the region are also given. Because of the lack of specific information on background radiation at the locations, the external-dose rates to people and the radioactivity levels in environmental media for the region have been taken from the literature. A background radiation survey will be conducted in the Palo Duro Basin to obtain additional data. 26 references, 3 figures, 15 tables

El Argot turístico y La teoría cognitiva de la metáfora y la metonimia

Directory of Open Access Journals (Sweden)

Rafael Rocamora Abellán

2000-01-01

Full Text Available El presente artículo es un modesto intento de ofrecer algunos ejemplos que demuestran la validez y la vigencia de la Teoría Cognitiva de la Metáfora y la Metonimia (TCMM por medio de ejemplos extraídos del lenguaje técnico usado por los profesionales del sector turístico Tal y como otros investigadores han señalado, la investigación en Lingüística Cognitiva y, especialmente, sobre la metáfora y la metonimia puede ser aplicada a varias disciplinas (ver Cameron y Low 1999. Nos referiremos aquí a los trabajos de algunos especialistas (Barcelona, 1997,2000 a, 2000 b, 2000 c; Kovecses y Radden, 1998 y Turner y Fauconnier, 2000 quienes han abierto nuevas líneas de investigación en la TCMM. La teoría resultante de tal investigación es extremadamente útil para la enseñanza del Inglés con Fines Específicos, particularmente en lo que se refiere a la semántica de cualquier campo. Como en cualquier otro tipo de jerga, el Inglés del Turismo es bastante difícil debido a la variedad y a la cantidad de vocabulario que hay que manejar, ya que incluye elementos de disciplinas tan diversas como geografía, arte, marketing, hoteles, agencias de viaje, etc. Al mismo tiempo, este tipo de argot ofrece un buen número de casos que se pueden comprender en profundidad por medio de la TCMM. Unos cuantos de estos casos serán analizados como paso previo a una línea investigadora que se centrará en la importancia de la aplicación de la TCMM al estudio del marketing, en especial en lo referido a la industria del Turismo.

Maurizio Lo Vetere (1965 - 2015)

CERN Multimedia

2015-01-01

The high-energy physics community mourns the sudden loss of Maurizio Lo Vetere, CMS and TOTEM member, who was the victim of a bike accident.   On 8 August, 2015, during a mountain bike ride in the upland of his hometown of Genoa, Italy, 50-year-old Maurizio Lo Vetere fell down a scarp. By the time first-aiders arrived on the scene, it was too late. Maurizio was an Associate Professor of the University of Genoa and team leader of the Genoa group in CMS. He began his career in high-energy physics at CERN, working first as an undergraduate, and subsequently as a PhD student on experiment PS202 (JETSET) at LEAR. During his PhD years, he also contributed to experiment PS210, which produced and observed antihydrogen atoms for the first time. In the following years, he moved to experiment E835 at Fermilab, which was dedicated to the study of charmonium spectroscopy. In 1996, he joined the BaBar collaboration at SLAC, where, for a decade, he made significant contributions, in particular to the con...

Testing and sampling of deep brine aquifers in the Palo Duro Basin, West Texas

International Nuclear Information System (INIS)

Deyling, M.A.

1984-01-01

The US Department of Energy is investigating the Palo Duro Basin of West Texas along with locations in Nevada, Washington, Utah, Mississippi and Louisiana as potential sites for storage of high-level nuclear waste. Ten wells have been drilled to depths between 3000 and 8300 feet. Testing and sampling of deep test zones requires advance planning and analysis of what must be obtained from the well. Various alternatives are available depending on data needs. In this particular instance, both hydrologic and geochemical data were required. The methods chosen were field proven methods used in the oil field industry for many years. Short term testing has included conventional oil-field-type drill stem tests and drill stem equipment with surface pressure readout. Long term testing has consisted of a series of production and recovery tests. Fluid sampling was performed in two stages. The first was at the well head under an imposed pressure of several hundred psi. The second fluid samples were collected downhole at the production zone under pressures close to ambient pressure. The geochemical data and hydrologic data can be used as independent checks on each other in many cases. Test results from the well along with examination of recovered core provided maximum data for each well. 5 references, 8 figures

Targeting MET Amplification as a New Oncogenic Driver

International Nuclear Information System (INIS)

Kawakami, Hisato; Okamoto, Isamu; Okamoto, Wataru; Tanizaki, Junko; Nakagawa, Kazuhiko; Nishio, Kazuto

2014-01-01

Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy

Targeting MET Amplification as a New Oncogenic Driver

Energy Technology Data Exchange (ETDEWEB)

Kawakami, Hisato [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Okamoto, Isamu, E-mail: okamotoi@kokyu.med.kyushu-u.ac.jp [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Center for Clinical and Translational Research, Kyushu University Hospital, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582 (Japan); Okamoto, Wataru [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Division of Transrlational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577 (Japan); Tanizaki, Junko [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, HIM223, 450 Brookline Avenue, Boston, MA 02215 (United States); Nakagawa, Kazuhiko [Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan); Nishio, Kazuto [Department of Genome Biology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511 (Japan)

2014-07-22

Certain genetically defined cancers are dependent on a single overactive oncogene for their proliferation and survival, a phenomenon known as “oncogene addiction”. A new generation of drugs that selectively target such “driver oncogenes” manifests a clinical efficacy greater than that of conventional chemotherapy in appropriate genetically defined patients. MET is a proto-oncogene that encodes a receptor tyrosine kinase, and aberrant activation of MET signaling occurs in a subset of advanced cancers as result of various genetic alterations including gene amplification, polysomy, and gene mutation. Our preclinical studies have shown that inhibition of MET signaling either with the small-molecule MET inhibitor crizotinib or by RNA interference targeted to MET mRNA resulted in marked antitumor effects in cancer cell lines with MET amplification both in vitro and in vivo. Furthermore, patients with non-small cell lung cancer or gastric cancer positive for MET amplification have shown a pronounced clinical response to crizotinib. Accumulating preclinical and clinical evidence thus suggests that MET amplification is an “oncogenic driver” and therefore a valid target for treatment. However, the prevalence of MET amplification has not been fully determined, possibly in part because of the difficulty in evaluating gene amplification. In this review, we provide a rationale for targeting this genetic alteration in cancer therapy.

Mars MetNet Mission Payload Overview

Science.gov (United States)

Harri, A.-M.; Haukka, H.; Alexashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.

2012-09-01

A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide crucial scientific data about the Martian atmospheric phenomena.

Development of HiLo Microscope and its use in In-Vivo Applications

Science.gov (United States)

Patel, Shreyas J.

The functionality of achieving optical sectioning in biomedical research is invaluable as it allows for visualization of a biological sample at different depths while being free of background scattering. Most current microscopy techniques that offer optical sectioning, unfortunately, require complex instrumentation and thus are generally costly. HiLo microscopy, on the other hand, offers the same functionality and advantage at a relatively low cost. Hence, the work described in this thesis involves the design, build, and application of a HiLo microscope. More specifically, a standalone HiLo microscope was built in addition to implementing HiLo microscopy on a standard fluorescence microscope. In HiLo microscopy, optical sectioning is achieved by acquiring two different types of images per focal plane. One image is acquired under uniform illumination and the other is acquired under speckle illumination. These images are processed using an algorithm that extracts in-focus information and removes features and glare that occur as a result of background fluorescence. To show the benefits of the HiLo microscopy, several imaging experiments on various samples were performed under a HiLo microscope and compared against a traditional fluorescence microscope and a confocal microscope, which is considered the gold standard in optical imaging. In-vitro and ex-vivo imaging was performed on a set of pollen grains, and optically cleared mouse brain and heart slices. Each of these experiments showed great reduction in background scattering at different depths under HiLo microscopy. More importantly, HiLo imaging of optically cleared heart slice demonstrated emergence of different vasculature at different depths. Reduction of out-of-focus light increased the spatial resolution and allowed better visualization of capillary vessels. Furthermore, HiLo imaging was tested in an in-vivo model of a rodent dorsal window chamber model. When imaging the same sample under confocal microscope

El anudamiento de lo sexual y lo cultural en la obra de Freud

Directory of Open Access Journals (Sweden)

Gómez Sánchez, Carlos

2007-02-01

Full Text Available The study of the culture in Freud was not a mere complement, but it contributed from its beginning to forge the psychoanalytic hypotheses and concepts. It is essential, nevertheless, to indicate the characters and limits of the “applied psychoanalysis” (1. After reconsidering the Freudian concept of sexuality –driven, non instinctive– and the controversy with authors like Bloch, the purpose of this article is to show why –for Freud– it is the repressed sexuality that structures the psychic apparatus (2. Through Mourning and Melancholia and The Ego and the Id this article analyzes the knotting established by Freud between the sexuality and the culture, between the wish and the rule (3, with the final intention of finding in the tension between archaism and progress (4 one of the cultural problems boarded in Freud’s final works, the conception of history, and to point out the main lines of influence of the psychoanalysis in the philosophical thought of the twentieth century.El estudio de la cultura no fue en Freud un mero complemento, sino que contribuyó desde un principio a fraguar las hipótesis y conceptos psicoanalíticos. Es preciso, sin embargo, señalar los caracteres y límites del “psicoanálisis aplicado” (1. Tras reconsiderar el concepto freudiano de sexualidad –pulsional, no instintiva– y la polémica con autores como Bloch, se trata de poner de manifiesto por qué, para Freud, es la sexualidad lo que se reprime y estructura el psiquismo (2. A través de Duelo y melancolía y El yo y el ello se analiza el anudamiento establecido por Freud entre lo sexual y lo cultural, entre el deseo y la norma (3, para plantear, finalmente, en la tensión entre arcaísmo y progreso (4, uno de los problemas culturales abordados en las obras finales de Freud, el de la concepción de la historia, y apuntar las principales líneas de influencia del psicoanálisis en el pensamiento filosófico del siglo XX.

Maniobras estratégicas: combinando lo razonable y lo efectivo en el discurso argumentativo

Directory of Open Access Journals (Sweden)

Frans H. van Eemeren

2013-02-01

Full Text Available Después de explicar su concepción de la argumentación como tema para teorizar, Frans H. van Eemeren presenta un esbozo del programa de investigación del acercamiento pragma-dialéctico a la argumentación, introduciendo los principales componentes de la teoría de la argumentación que resultan del desarrollo de este programa. Posteriormente se centra en el problema fundamental que confrontan los teóricos de la argumentación al buscar distinguir entre los movimientos argumentativos razonables y los falaces. Al respecto, presenta el tratamiento pragma-dialéctico de las falacias como una alternativa constructiva a las severas críticas dirigidas al tratamiento estándar lógico. En la perspectiva pragma-dialéctica, las falacias se consideran violaciones de las reglas para conducir una discusión crítica orientada a resolver una diferencia de opinión de fondo, lo que está en juego en el discurso argumentativo. Van Eemeren introduce la noción de maniobra estratégica para explicar el poder persuasivo de las falacias, a pesar de tratarse de argumentaciones que van en contra de lo razonable. La noción de maniobra estratégica captura el predicamento inherente a todo movimiento argumentativo de reconciliar, a la vez, la búsqueda de resultados efectivos con la necesidad de respetar parámetros razonables. Las falacias son descarrilamientos de las maniobras estratégicas que violan una o más reglas de la discusión crítica. A través de la distinción entre un argumento de autoridad razonable y el argumentum ad verecundiam (que corresponde con una falacia van Eemeren concluye su ensayo explicando, con este ejemplo, por qué los descarrilamientos de las maniobras estratégicas pueden, en la práctica, pasar tan fácilmente inadvertidos, lo que ayuda a que las falacias no sean detectadas.

Ervaringen met beeldverwerking.

NARCIS (Netherlands)

Meuleman, J.

1989-01-01

Verslag van een werkbezoek aan het Franse instituut Cemagref, met nadruk op beeldverwerking. Toepassingen van beeldverwerking zijn onder andere: een plukrobot voor appels; het detecteren van oppervlaktebeschadigingen bij appels; het detecteren van breuk in eieren; remote sensing

Library Service Marketing Based on SoLoMo%基于SoLoMo的图书馆服务营销

Institute of Scientific and Technical Information of China (English)

时婉璐

2012-01-01

SoLoMo is the integration of social, local and mobile. It is viewed as the future trend of the development of the internet, and offers new directions for the library service marketing. In the face of the change of users' information behaviors and the social information environment, libraries should catch and formulate timely strategies, use the concept of SoLoMo effectively, build the social media marketing map actively, establish the local word-of-mouth network, and benefit from the mobile, in order to meet the revolution and challenge presented by the new information environment.%由Social（社交）、Local（本地化）和Mobile（移动）整合而来的SoLoMo被一致认为是互联网未来的发展趋势，为图书馆未来的服务营销提供了新方向。面对用户信息行为、社会信息环境的变化，图书馆应该捕捉和制订适时的策略，有效利用SoLoMo概念，积极创建社会化媒体营销地图，建立本地化口碑网络，使图书馆在移动中得到实惠，迎接新信息环境带来的变革与挑战。

Bajo vientre: Representaciones de la sexualidad en la cultura y el arte contemporáneo. El arte impuro: Entre lo público y lo privado

OpenAIRE

Cuéllar, Carlos A.

1998-01-01

Cuéllar, CA. (1998). Bajo vientre: Representaciones de la sexualidad en la cultura y el arte contemporáneo. El arte impuro: Entre lo público y lo privado. Banda aparte. (11):89-89. http://hdl.handle.net/10251/43155. 89 89 11

El Silencio de la Sirena: lo Sublime en Alejandra Pizarnik

Directory of Open Access Journals (Sweden)

Julieta Lerman

2012-12-01

Full Text Available Algunas poéticas de las décadas del cincuenta y del sesenta parecerían constituirse en torno a un vacío, un silencio que a veces inspira la palabra poética y otras veces la aborta. Esa ambigüedad, característica de la poética de Alejandra Pizarnik, podemos entenderla como una “reedición” de la estética de lo sublime. Lo sublime es un concepto estético-filosófico que plantearon filósofos como Inmanuel Kant y Edmund Burke para pensar el arte romántico y, en el siglo XX, otros autores como Jean-François Lyotard, lo retomaron para analizar el arte de vanguardia. Así, lo sublime nos permite repensar la poética de Pizarnik en sus coincidencias y oposiciones a otras de la tradición moderna (como la de Charles Baudelaire o de las vanguardias latinoamericanas (como Oliverio Girondo y Vicente Huidobro.

Alkaline transition of pseudoazurin Met16X mutant proteins: protein stability influenced by the substitution of Met16 in the second sphere coordination.

Science.gov (United States)

Abdelhamid, Rehab F; Obara, Yuji; Kohzuma, Takamitsu

2008-01-01

Several blue copper proteins are known to change the active site structure at alkaline pH (alkaline transition). Spectroscopic studies of Met16Phe, Met16Tyr, Met16Trp, and Met16Val pseudoazurin variants were performed to investigate the second sphere role through alkaline transition. The visible electronic absorption and resonance Raman spectra of Met16Phe, Met16Tyr, and Met16Trp variants showed the increasing of axial component at pH approximately 11 like wild-type PAz. The visible electronic absorption and far-UV CD spectra of Met16Val demonstrated that the destabilization of the protein structure was triggered at pH>11. Resonance Raman (RR) spectra of PAz showed that the intensity-weighted averaged Cu-S(Cys) stretching frequency was shifted to higher frequency region at pH approximately 11. The higher frequency shift of Cu-S(Cys) bond is implied the stronger Cu-S(Cys) bond at alkaline transition pH approximately 11. The visible electronic absorption and far-UV CD spectra of Met16X PAz revealed that the Met16Val variant is denatured at pH>11, but Met16Phe, Met16Tyr, and Met16Trp mutant proteins are not denatured even at pH>11. These observations suggest that Met16 is important to maintain the protein structure through the possible weak interaction between methionine -SCH3 part and coordinated histidine imidazole moiety. The introduction of pi-pi interaction in the second coordination sphere may be contributed to the enhancement of protein structure stability.

Optically sectioned in vivo imaging with speckle illumination HiLo microscopy

Science.gov (United States)

Lim, Daryl; Ford, Tim N.; Chu, Kengyeh K.; Mertz, Jerome

2011-01-01

We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with standard uniform illumination. The fusion can be numerically adjusted, using a single parameter, to produce optically sectioned images of varying thicknesses with the same raw data. Direct comparison between our HiLo microscope and a commercial confocal laser scanning microscope is made on the basis of sectioning strength and imaging performance. Specifically, we show that HiLo and confocal 3-D imaging of a GFP-labeled mouse brain hippocampus are comparable in quality. Moreover, HiLo microscopy is capable of faster, near video rate imaging over larger fields of view than attainable with standard confocal microscopes. The goal of this paper is to advertise the simplicity, robustness, and versatility of HiLo microscopy, which we highlight with in vivo imaging of common model organisms including planaria, C. elegans, and zebrafish.

Impact of foliage on LoRa 433MHz propagation in tropical environment

Science.gov (United States)

Ahmad, Khairol Amali; Salleh, Mohd Sharil; Segaran, Jivitraa Devi; Hashim, Fakroul Ridzuan

2018-02-01

LoRa is being considered as one of the promising system for Low-Power-Wide-Area-Network (LPWAN) to support the growth of Internet of Things (IoT) applications. Designed to operate in the industrial, scientific and medical (ISM) bands, LoRa had been tested and evaluated mainly in Europe and US in the 868 MHz and 915 MHz modulation bands. Using chirp spread spectrum technology, LoRa is expected to be robust against degredation. This paper provides some early results in the performance of LoRa signal propagation of 433 MHz modulation in tropical foliage environments.

Autorijden met ADHD

NARCIS (Netherlands)

Fuermaier, Anselm B.M.; Tucha, Lara; de Vries, Stefanie M.; Koerts, Janneke; de Waard, Dick; Brookhuis, Karel; Tucha, Oliver

Volwassenen met attention deficit hyperactivity disorder (ADHD) hebben uiteenlopende cognitieve beperkingen, die een aanzienlijke invloed kunnen hebben op verschillende aspecten van het dagelijks leven. Een van deze aspecten is het besturen van een auto. Autorijden is een belangrijke activiteit in

Research progress in c-Met and hepatocellular carcinoma

Directory of Open Access Journals (Sweden)

WANG Changqing

2015-06-01

Full Text Available c-Met plays a pivotal role in the development and progression of hepatocellular carcinoma (HCC, which can lead to proliferation, survival, cytoskeleton reorganization, separation and diffusion, and angiogenesis of tumor cells. Moreover, c-Met is an important prognostic factor for HCC. In HCC, c-Met acts as an activator of a series of signaling pathways, including PI3K/AKT/mTOR, ERK/MAPK, and Rac-Pak. In recent years, it has been reported that small-molecule kinase inhibitors can abolish phosphorylation at the intracellular carboxyl terminal of c-Met, and then inhibit the recruitment of signal convertors and downstream signaling pathways, which finally achieve anti-tumor activities. Based on the carcinogenic activity of c-Met in HCC, this paper points out that selective inhibitors of c-Met hold promise for targeted therapies for HCC.

A metáfora teatral como representação social para Erving Goffman: um ensaio teórico

Directory of Open Access Journals (Sweden)

Danilo Henrique Martins

2014-11-01

Full Text Available Erving Goffman (1922-1982 desenvolve o estudo da representação baseando-se na metáfora da ação teatral como ponto norteador estrutural de sua exposição. Preocupando-se em ir além das representações teatrais apresentadas no cotidiano, Erving Goffman buscou realizar uma análise das situações dentro das interações, os chamados encontros sociais. Pensar como Goffman desenvolveu seu método torna-se imprescindível para aplicá-lo em futuras pesquisas. O presente ensaio apresentou uma reflexão do pensamento teórico-metodológico de Erving Goffman acerca da metáfora teatral da vida social como palco de atuação tendo como ponto de partida as principais referências bibliográficas que este autor utilizou para sustentar seus argumentos, pois tais autores influenciaram com riqueza o pensamento goffmaniano. O ensaio demonstrou que Goffman não se prendeu a teoria defendida pelos autores de sua referência, mas procurou reinterpretar tais ideias e transformá-las para aplicar em sua própria teoria

Modelos democráticos con pretensiones emancipatorias: una invitación a transitar de lo racional a lo razonable

Directory of Open Access Journals (Sweden)

Mariluz Nova Laverde

2016-07-01

Full Text Available Los grandes debates suscitados por Teoría de la justicia de John Rawls determinaron lo que los analistas han denominado el giro político de su pensamiento, el cual se materializa en el Liberalismo político. Allí, Rawls consolida un modelo de democracia consensual, controvirtiendo y apartándose del liberalismo doctrinario. La hipótesis a desarrollar en este documento es que un análisis del paso de la concepción de un agente liberal individualista de Teoría de la justicia a la concepción política de persona de Liberalismo político favorece una lectura crítica de la posterior eclosión de teorías de la democracia como instrumento de emancipación, toda vez que pone de presente el carácter enajenante de la idea de racionalidad que ha conducido a la autodestrucción del proyecto de la Ilustración como ideario emancipatorio. Lo anterior, además, conduce a la reflexión respecto de lo que constituye un régimen justo, cuestión que cobra la mayor importancia en la coyuntura de búsquedas de salidas negociadas al conflicto armado en Colombia.

“LO FAMILIAR EN LAS CREENCIAS Y LAS CREENCIAS EN LO FAMILIAR”: FAMILIA, TRANSMISIÓN Y RELIGIÓN EN LA ARGENTINA ACTUAL.

Directory of Open Access Journals (Sweden)

Verónica Giménez-Béliveau

2012-10-01

Full Text Available En tanto dispositivo central de la reproducción social, la familia es una palanca fundamental de la transmisión de la religión. Es que el grupo doméstico, actúa tanto en el plano de lo “físico” como de lo “espiritual”: la reproducción social en las sociedades occidentales modernas reconoce como uno de sus lugares privilegiados a la familia nuclear, y esto se refiere tanto a la reproducción de sus miembros (nacimientos como a la reproducción de valores, estándares de vida, posiciones sociales y también adscripciones, prácticas y creencias religiosas. La propuesta de este trabajo es trazar algunas líneas de análisis en torno al eje familia-religión en la Argentina actual centrándonos en la transmisión familiar de las religiones. Reflexionaremos sobre la incidencia de lo familiar en la conformación de identidades religiosas y, a su vez, cómo lo religioso contribuye diferencialmente a la cohesión de las unidades domésticas. Para ello, analizaremos las tramas de la transmisión y apropiación familiar de creencias, prácticas y ritosreligiosos en la estructura social argentina.

LO CIERTO Y LO INCIERTO DEL JUEGO Y LA LÚDICA EN LA ESCUELA

Directory of Open Access Journals (Sweden)

Jenny Johana Castro Ballén

2014-03-01

Full Text Available El presente escrito contiene la reflexión sobre el papel que cumplen el juego y la lúdica en la escuela apartir de lo que maestras y maestros piensan sobre estos dos conceptos y, en general, desde la preocupaciónporque cada vez más la escuela, como institución social, pareciera querer alejar al individuo deconstruirse como ser humano y social debido a su carácter prescriptivo hasta para el goce, el disfrutede placeres sencillos, el ocio, el tiempo libre, entre otros. Las ideas y cuestionamientos sobre las prácticas,usos y desusos del juego y la lúdica que aquí se exponen tienen como propósito invitar al lectora dialogar, actuar y transformar las prácticas educativas caracterizadas por actividades condicionadasque corroboran el deseo de control y disciplinamiento de la institución escolar, pues continúa predominandola perspectiva utilitaria del juego y la lúdica en la escuela. Desde allí se construye una críticacontundente que, se espera, anime la búsqueda y fortalecimiento de experiencias alternativas para eltiempo y el espacio escolar, subvirtiendo el orden establecido y reivindicando el placer y la diversiónen lo cotidiano.

Optically Sectioned Imaging of Microvasculature of In-Vivo and Ex-Vivo Thick Tissue Models with Speckle-illumination HiLo Microscopy and HiLo Image Processing Implementation in MATLAB Architecture

Science.gov (United States)

Suen, Ricky Wai

The work described in this thesis covers the conversion of HiLo image processing into MATLAB architecture and the use of speckle-illumination HiLo microscopy for use of ex-vivo and in-vivo imaging of thick tissue models. HiLo microscopy is a wide-field fluorescence imaging technique and has been demonstrated to produce optically sectioned images comparable to confocal in thin samples. The imaging technique was developed by Jerome Mertz and the Boston University Biomicroscopy Lab and has been implemented in our lab as a stand-alone optical setup and a modification to a conventional fluorescence microscope. Speckle-illumination HiLo microscopy combines two images taken under speckle-illumination and standard uniform-illumination to generate an optically sectioned image that reject out-of-focus fluorescence. The evaluated speckle contrast in the images is used as a weighting function where elements that move out-of-focus have a speckle contrast that decays to zero. The experiments shown here demonstrate the capability of our HiLo microscopes to produce optically-sectioned images of the microvasculature of ex-vivo and in-vivo thick tissue models. The HiLo microscope were used to image the microvasculature of ex-vivo mouse heart sections prepared for optical histology and the microvasculature of in-vivo rodent dorsal window chamber models. Studies in label-free surface profiling with HiLo microscopy is also presented.

Lo práctico y lo formal. Arquetipos masculino/femenino de poder

OpenAIRE

García de León Álvarez, María Antonia

2008-01-01

La autora efectúa una síntesis de sus numerosas investigaciones sobre las élites femeninas españolas en los más diversos campos (académico, científico, político, periodístico, etc.) y su relación con el poder. Reconduce sus observaciones a dos arquetipos, al modo de dicotomías «levistrausianas»: lo práctico y formal, siendo el primero ejemplificado en la universal figura literaria quijotesca que la autora denomina «sanchas». Sobre dicha dualidad, la autora realiza un esfuerzo de interpretació...

El acuerdo de París: entre lo posible y lo necesario

OpenAIRE

Heras Hernández, Francisco

2017-01-01

El 12 de Diciembre de 2015 en el seno de Naciones Unidas 195 países adoptaron el denominado Acuerdo de París, comprometiéndose a limitar las emisiones de gases de efecto invernadero(GEI), que son el motor del cambio climático. Una vez pasadas las primeras reacciones de satisfaccióno de decepción, el desarrollo del Acuerdo suscita una serie de interrogantes: ¿Qué retos plantea a las partes firmantes? ¿Qué repercusiones tendrá en el corto y en el medio plazo? Y lo más importante: ¿Será un i...

MET amplification, expression, and exon 14 mutations in colorectal adenocarcinoma.

Science.gov (United States)

Zhang, Meng; Li, Guichao; Sun, Xiangjie; Ni, Shujuan; Tan, Cong; Xu, Midie; Huang, Dan; Ren, Fei; Li, Dawei; Wei, Ping; Du, Xiang

2018-04-08

MET amplification, expression, and splice mutations at exon 14 result in dysregulation of the MET signaling pathway. The aim of this study was to identify the relationship between MET amplification, protein or mRNA expression, and mutations in colorectal cancer (CRC). MET immunohistochemistry (IHC) was used for MET protein expression analysis and fluorescence in situ hybridization (FISH) was used for MET amplification detection. Both analyses were performed in tissue microarrays (TMA) containing 294 of colorectal adenocarcinoma tissue samples and 131 samples of adjacent normal epithelial tissue. MET mRNA expression was examined by real-time quantitative polymerase chain reaction (qRT-PCR) in 72 fresh colorectal adenocarcinoma tissue samples and adjacent normal colon tissue. PCR sequencing was performed to screen for MET exon 14 splice mutations in 59 fresh CRC tissue samples. Our results showed that MET protein expression was higher in colorectal tumor tissue than in adjacent normal intestinal epithelium. Positive MET protein expression was associated with significantly poorer overall survival (OS) and disease-free survival (DFS). Multivariate analysis revealed that positive MET protein expression was an independent risk factor for DFS, but not for OS. MET mRNA expression was upregulated in tumor tissues compared with the adjacent normal tissues. The incidence of MET amplification was 4.4%. None of the patients was positive for MET mutation. Collectively, MET was overexpressed in colorectal adenocarcinoma, and its positive protein expression predicted a poorer outcome in CRC patients. Furthermore, according to our results, MET amplification and 14 exon mutation are extremely rare events in colorectal adenocarcinoma. Copyright © 2018. Published by Elsevier Inc.

Jeugd met beperkingen

NARCIS (Netherlands)

Sjoerd Kooiker

2006-01-01

Voor kinderen en jongeren met een lichamelijke of verstandelijke beperking is 'gewoon meedoen' in de samenleving geen vanzelfsprekendheid.  Zij ervaren vaak meer obstakels bij het naar school gaan, het vinden van een baan en in hun vrijetijdsbesteding dan andere kinderen en jongeren. Ook

SPSS met syntax

NARCIS (Netherlands)

Grotenhuis, H.F. te; Visscher, C.A.M.

2007-01-01

Dit boekje wijkt af van de gebruikelijke statistiekboeken omdat het sec gaat over het bekende statistische computerprogramma SPSS, en dan alleen nog de oorspronkelijke variant waarin wordt gewerkt met syntax (intypen commando's -zoals bij DOS) i.p.v. de later ontwikkelde 'Windows-schil' (aanklikken

Amount and nature of occluded water in bedded salt, Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Fisher, R.S.

1987-01-01

The quantity and types of fluids within bedded salt cores from the Permian San Andres Formation, Palo Duro, Texas, were evaluated at the Texas Bureau of Economic Geology. Bedded halite from the San Andres Formation and other salt-bearing units were selected to represent the variety of salt types present, and were then analyzed. The mean water content of ''pure'' samples (more than 90% halite) is 0.4 weight percent, with none observed greater than 1.0 weight percent. Samples that contain more than 10 weight percent clay or mudstone display a trend of increasing water content with increasing clastic material. Chaotic mudstone-halite samples have as much as 5 weight percent water; halite-cemented mudstone interlayers, common throughout the bedded salts, may have water content values as high as 10 to 15 weight percent based on extrapolation of existing data that range from 0 to about 6%. No significant difference exists between the mean water content values of ''pure salt'' from the upper San Andres, lower San Andres Cycle 5, and lower San Andres Cycle 4 salt units. The fraction of total water present as mobile intergranular water is highly variable and not readily predicted from observed properties of the salt sample. The amount of water that would be affected by a high-level nuclear waste repository can be estimated if the volume of halite, the volume of clastic interlayers, and the amount and type of impurity in halite are known. Appendix contains seven vugraphs

PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

International Nuclear Information System (INIS)

Crosswell, Hal E; Dasgupta, Anindya; Alvarado, Carlos S; Watt, Tanya; Christensen, James G; De, Pradip; Durden, Donald L; Findley, Harry W

2009-01-01

c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), and both c-Met and its ligand are expressed in a variety of tissues. C-Met/HGF/SF signaling is essential for normal embryogenesis, organogenesis, and tissue regeneration. Abnormal c-Met/HGF/SF signaling has been demonstrated in different tumors and linked to aggressive and metastatic tumor phenotypes. In vitro and in vivo studies have demonstrated inhibition of c-Met/HGF/SF signaling by the small-molecule inhibitor PHA665752. This study investigated c-Met and HGF expression in two neuroblastoma (NBL) cell lines and tumor tissue from patients with NBL, as well as the effects of PHA665752 on growth and motility of NBL cell lines. The effect of the tumor suppressor protein PTEN on migration and proliferation of tumor cells treated with PHA665752 was also evaluated. Expression of c-Met and HGF in NBL cell lines SH-EP and SH-SY5Y and primary tumor tissue was assessed by immunohistochemistry and quantitative RT-PCR. The effect of PHA665752 on c-Met/HGF signaling involved in NBL cell proliferation and migration was evaluated in c-Met-positive cells and c-Met-transfected cells. The transwell chemotaxis assay and the MTT assay were used to measure migration and proliferation/cell-survival of tumor cells, respectively. The PPAR-γ agonist rosiglitazone was used to assess the effect of PTEN on PHA665752-induced inhibition of NBL cell proliferation/cell-survival and migration High c-Met expression was detected in SH-EP cells and primary tumors from patients with advanced-stage disease. C-Met/HGF signaling induced both migration and proliferation of SH-EP cells. Migration and proliferation/cell-survival were inhibited by PHA665752 in a dose-dependent manner. We also found that induced overexpression of PTEN following treatment with rosiglitazone significantly enhanced the inhibitory effect of PHA665752 on NBL-cell migration and proliferation. c-Met is highly expressed in most tumors from

Dissection of combinatorial control by the Met4 transcriptional complex.

Science.gov (United States)

Lee, Traci A; Jorgensen, Paul; Bognar, Andrew L; Peyraud, Caroline; Thomas, Dominique; Tyers, Mike

2010-02-01

Met4 is the transcriptional activator of the sulfur metabolic network in Saccharomyces cerevisiae. Lacking DNA-binding ability, Met4 must interact with proteins called Met4 cofactors to target promoters for transcription. Two types of DNA-binding cofactors (Cbf1 and Met31/Met32) recruit Met4 to promoters and one cofactor (Met28) stabilizes the DNA-bound Met4 complexes. To dissect this combinatorial system, we systematically deleted each category of cofactor(s) and analyzed Met4-activated transcription on a genome-wide scale. We defined a core regulon for Met4, consisting of 45 target genes. Deletion of both Met31 and Met32 eliminated activation of the core regulon, whereas loss of Met28 or Cbf1 interfered with only a subset of targets that map to distinct sectors of the sulfur metabolic network. These transcriptional dependencies roughly correlated with the presence of Cbf1 promoter motifs. Quantitative analysis of in vivo promoter binding properties indicated varying levels of cooperativity and interdependency exists between members of this combinatorial system. Cbf1 was the only cofactor to remain fully bound to target promoters under all conditions, whereas other factors exhibited different degrees of regulated binding in a promoter-specific fashion. Taken together, Met4 cofactors use a variety of mechanisms to allow differential transcription of target genes in response to various cues.

Metáforas para profesor y estudiante de pedagogía en un grupo de estudiantes de pedagogía chilenos

Directory of Open Access Journals (Sweden)

Paola Alarcón

2014-05-01

Full Text Available En este artículo se presentan los resultados de una investigación de tipo cualitativo, cuyo objetivo general es identificar los conceptos metafóricos los estudiantes de pedagogía acerca de cómo ellos creen que el profesor es representado por la sociedad, y como representan ellos a sí mismos. El marco de referencia lo constituyen la cognición docente y la metáfora conceptual. Para la elicitación de metáforas se aplicó un cuestionario a un grupo de 70 estudiantes de Pedagogía de la Universidad de Concepción, Chile. Se realizó un análisis de contenido que abarcó las siguientes etapas: etiquetado, clasificación, categorización y juicio de externos. Para las metáforas sobre cómo es representado el profesor por la sociedad, a través del análisis, se identificaron las siguientes categorías: Metáforas centradas en el profesor, Metáforas centradas en el estudiante, Metáforas centradas en la valoración social. Para las metáforas sobre cómo es representado el estudiante de pedagogía se identificaron las siguientes categorías: Metáforas centradas en el proceso de formación profesional, Metáforas centradas en el proceso de enseñanza aprendizaje, Metáforas centradas en la valoración social. Finalmente, se comentan los alcances y proyecciones del estudio, y se discute la pertinencia de algunas categorías en el contexto de la formación de profesores. This article provides the results of a qualitative study, whose main objective is to identify the metaphorical concepts through which teacher candidates believe how teachers are represented by society, and how they represent themselves. The referential framework of this study is given by teacher cognition and conceptual metaphor. A questionnaire was applied to elicit metaphors from 70 teacher candidates at the University of Concepción, Chile. Content analysis was used, following these stages: coding, classification, categorization and scholar review. For the metaphors on how

Innoveren met serious games : Wat is serious gaming?

NARCIS (Netherlands)

Werkhoven, P.J.

2008-01-01

Het begrip serious gaming is inmiddels gekaapt door vele aanbieders van wat vroeger simulatie en virtual reality technologie genoemd werd. Met die technologie kunnen we mensen laten rondlopen in virtuele gebouwen en landschappen, al dan niet met grote projectieschermen of met brillen op. Maar dat is

Depositional history of organic contaminants on the Palos Verdes Shelf, California

Science.gov (United States)

Eganhouse, R.P.; Pontolillo, J.

2000-01-01

During more than 60 years, sedimentation on the Palos Verdes Shelf has been dominated by time-varying inputs of municipal wastewater from the Los Angeles County Sanitation Districts (LACSD) and debris from the Portuguese Bend Landslide (PBL). The present study examines the depositional history of wastewater-derived organic contaminants at a site approximately 6-8 km downcurrent from the outfall system. Sediments at this location are impacted by contributions from both sources, but the relative influence of the sources has changed over time. Two classes of hydrophobic organic contaminants (chlorinated hydrocarbons, long-chain alkylbenzenes) were determined in sediment cores collected in 1981 and 1992. Using molecular stratigraphy, we determined average sedimentation rates (cm/year) and mass accumulation rates (g cm-2 year-1) for the following periods: 1955-1965, 1965-1971, 1971-1981 and 1981-1992. The results show that sedimentation and mass accumulation rates increased from 1955 to 1971 and decreased from 1971 to 1981. These trends are consistent with historical information on the emission of suspended solids from the outfall system, indicating that the discharge of wastes dominated sedimentation at the site during this period. In the 1980s and early 1990s, however, mass accumulation rates increased in spite of continually decreasing emissions of wastewater solids. Several lines of evidence indicate that this increase was due to mobilization of debris from the PBL during and after unusually strong winter storms in the 1980s. As a result, heavily contaminated sediments deposited during the years of greatest waste emissions (i.e. 1950-1970) have been buried to greater sub-bottom depths, thereby reducing their availability for mobilization to the overlying water column. These results highlight the dynamic nature of sedimentation in contaminated coastal ecosystems and its importance to the long-term fate and effects of toxic substances.

What is effective is fair Lo eficaz es justo

Directory of Open Access Journals (Sweden)

Le Mouël Jacques

1997-06-01

Full Text Available In this text, which comes from Chapter 3 of his book, Jacques Le Mouel completes the philosophical reflection about the entrepreneurial myth of effectiveness founded in the sophism: "What is effective is true. What is true is faie. Therefore, what is effective is fair". The fact that management is elevated to the category of paradigm for the economic model of Western society and the collapse of the economies of the East has led to neglect that, now, we ourselves are the modelo His analysis of the supposed neutrality of science and of the differences between ethics and morality, in the framework of the firm and its relations with society, lead him to conclude that it is not true that what is effective is fair, and that the firm cannot serve as a model for contemporary society, since the end does not justify the means.En este texto, que corresponde al capitulo 3 de su libro, Jaques Le Mouël completa la reflexión filosófica sobre el mito empresarial de la eficacia funadado en el sofisma: "Lo eficaz es verdadero. Lo verdadero es justo. Luego, lo eficaz es justo". El hecho de elevar la administración a la categoría de paradigma del modelo económico de la sociedad occidental y el hundimiento de las economías del Este han llevado a ignorar que, ahora, el modelo somos nosotros mismos. Su análisis de la pretendida neutralidad de la ciencia y las diferencias entre ética y moral, en el marco de la empresa y en sus relaciones con la sociedad, lo lleva a concluir que no es cierto que lo eficaz sea justo y que la empresa no puede servir de modelo a la sociedad contemporánea, pues el fin no justifica los medios.

La metáfora como factor de textualidad en Ensayo sobre la lucidez, de José Saramago.

Directory of Open Access Journals (Sweden)

Olívia Maria Figueiredo

2006-06-01

Full Text Available La metáfora como factor de textualidad es una reflexión sobre el modo como el sistema de la lengua se operacionaliza en el discurso. En este caso concreto, como es que en la obra literaria Ensayo sobre la lucidez las expresiones idiomáticas (expresiones compósitas son transformadas de nuevo en expresiones metafóricas (expresiones componenciales. La incidencia del análisis se focaliza en la apreciación de cómo la expresión idiomática recupera su energía creadora y el primer impulso que la pone en circulación. Teniendo por fundamento las teorías de la anáfora (ampliada y de la reconceptualización, se muestra que tal reconversión se va haciendo a lo largo de la obra en un proceso de ampliación del enfoque cognitivo de que el recurso a las implicaturas es un trazo necesario para la comprensión de las explicaturas. Es preciso que el lector seleccione el contexto oportuno para entender pertinentemente el sentido comunicado. Y el sentido comunicado no es más que el cuestionamiento de la relación del hombre con el mundo por medio de la amplitud de escenarios metafóricos que sólo la lengua permite instaurar.

LoRa Scalability: A Simulation Model Based on Interference Measurements.

Science.gov (United States)

Haxhibeqiri, Jetmir; Van den Abeele, Floris; Moerman, Ingrid; Hoebeke, Jeroen

2017-05-23

LoRa is a long-range, low power, low bit rate and single-hop wireless communication technology. It is intended to be used in Internet of Things (IoT) applications involving battery-powered devices with low throughput requirements. A LoRaWAN network consists of multiple end nodes that communicate with one or more gateways. These gateways act like a transparent bridge towards a common network server. The amount of end devices and their throughput requirements will have an impact on the performance of the LoRaWAN network. This study investigates the scalability in terms of the number of end devices per gateway of single-gateway LoRaWAN deployments. First, we determine the intra-technology interference behavior with two physical end nodes, by checking the impact of an interfering node on a transmitting node. Measurements show that even under concurrent transmission, one of the packets can be received under certain conditions. Based on these measurements, we create a simulation model for assessing the scalability of a single gateway LoRaWAN network. We show that when the number of nodes increases up to 1000 per gateway, the losses will be up to 32%. In such a case, pure Aloha will have around 90% losses. However, when the duty cycle of the application layer becomes lower than the allowed radio duty cycle of 1%, losses will be even lower. We also show network scalability simulation results for some IoT use cases based on real data.

Cine y censura en Chile: Entre lo local y lo transnacional, 1910-1945

OpenAIRE

Purcell, Fernando

2011-01-01

Este trabajo considera el fenómeno de la censura cinematográfica en Chile durante la primera mitad del siglo XX. El argumento central, elaborado a partir de documentación recogida en Chile y los Estados Unidos, es que lejos de ser un fenómeno estrictamente local, la censura cinematográfica chilena se debatió y aplicó a la luz del diálogo y participación de numerosos y variados actores internacionales. Esto fue posible gracias al predominio hegemónico global del cine hollywoodense, lo que faci...

Nature of the interfacial region between cementitious mixtures and rocks from the Palo Duro Basin and other seal components

International Nuclear Information System (INIS)

Wakeley, L.D.; Roy, D.M.

1986-03-01

Using the interface zone as an indicator of compatibility, preliminary tests were run using cement-based formulations designed to be used for shaft sealing in conjunction with evaporite and clastic rocks of the Palo Duro Basin, one of several potential sites for a high-level radioactive waste repository. Emphasis focused on two formulations, both designed to be slightly expansive. Mixture 83-05 was tested in combination with anhydrite and siltstone. A comparable mixture (83-03) containing salt was used with the halite. Cement, rocks, and their respective interfaces were examined using x-ray diffraction, optical microscopy, and scanning electron microscopy. Bond strengths between rock and cement as well as between selected steels and grout were determined as a function of curing conditions and pretest surface treatment. Permeabilities of cement/rock and cement/steel composites were also determined. Bond strength and permeability were found to vary with curing conditions as well as surface treatment

The HGF Receptor c-Met Is Overexpressed in Esophageal Adenocarcinoma

Directory of Open Access Journals (Sweden)

Luis J. Herrera

2005-01-01

Full Text Available The hepatocyte growth factor (HGF receptor, Met, has established oncogenic properties; however, its expression and function in esophageal adenocarcinoma (EA remain poorly understood. We aimed to determine the expression and potential alterations in Met expression in EA. Met expression was investigated in surgical specimens of EA, Barrett's esophagus (BE, and normal esophagus (NE using immunohistochemistry (IHC and quantitative reverse transcriptase polymerase chain reaction. Met expression, phosphorylation, and the effect of COX-2 inhibition on expression were examined in EA cell lines. IHC demonstrated intense Met immunoreactivity in all (100% EA and dysplastic BE specimens. In contrast, minimal immunostaining was observed in BE without dysplasia or NE specimens. Met mRNA and protein levels were increased in three EA cell lines, and Met protein was phosphorylated in the absence of serum. Sequence analysis found the kinase domain of c-met to be wild type in all three EA cell lines. HGF mRNA expression was identified in two EA cell lines. In COX-2-overexpressing cells, COX-2 inhibition decreased Met expression. Met is consistently overexpressed in EA surgical specimens and in three EA cell lines. Met dysregulation occurs early in Barrett's dysplasia to adenocarcinoma sequence. Future study of Met inhibition as a potential biologic therapy for EA is warranted.

Nisine geholpen met hordentechnologie

NARCIS (Netherlands)

Jong, de L.S.

2001-01-01

Een combinatie van nisine met carvacrol, thymol of carvon leidde tot een synergistische reductie van het aantal levensvatbare cellen van Listeria monocytogenes en Bacillus cereus. Verslag van een promotieonderzoek

A Dual Key-Based Activation Scheme for Secure LoRaWAN

Directory of Open Access Journals (Sweden)

Jaehyu Kim

2017-01-01

Full Text Available With the advent of the Internet of Things (IoT era, we are experiencing rapid technological progress. Billions of devices are connected to each other, and our homes, cities, hospitals, and schools are getting smarter and smarter. However, to realize the IoT, several challenging issues such as connecting resource-constrained devices to the Internet must be resolved. Recently introduced Low Power Wide Area Network (LPWAN technologies have been devised to resolve this issue. Among many LPWAN candidates, the Long Range (LoRa is one of the most promising technologies. The Long Range Wide Area Network (LoRaWAN is a communication protocol for LoRa that provides basic security mechanisms. However, some security loopholes exist in LoRaWAN’s key update and session key generation. In this paper, we propose a dual key-based activation scheme for LoRaWAN. It resolves the problem of key updates not being fully supported. In addition, our scheme facilitates each layer in generating its own session key directly, which ensures the independence of all layers. Real-world experimental results compared with the original scheme show that the proposed scheme is totally feasible in terms of delay and battery consumption.

A comparison of metabolic syndrome (MetS) risk factors in Filipino women and Filipino American women: a pilot study.

Science.gov (United States)

Ancheta, Irma B; Battie, Cynthia A; Tuason, Teresa; Ancheta, Christine V

2012-01-01

Cardiovascular disease (CVD) is a significant cause of morbidity and mortality in women of Filipino ethnicity. The objective of our work was to determine if metabolic syndrome (MetS), a modifiable CVD risk factor, differs in women as a function of country of residency and to determine if, CVD prevention strategies need to differ for these groups of Filipino women. Data were collected in community-based health screenings for this cross-sectional study. PARTICIPANTS were recruited at places of worship in southeast United States (n=60) and Central Visayas, Philippines (n=56). Prevalence of MetS and its component factors as defined by the International Diabetes Federation criteria. The prevalence of MetS in Filipino women (FW) and Filipino American women (FAW) groups was similar (52% vs 55%, P=.08) although the prevalence of elevated waist circumference was greater for FAW (78% vs 59%, P=.03). Conversely, the percentage of FW women with risk-associated high-density lipoprotein (HDL) levels was higher than the FAW group (84% vs 42%, PFilipino women regardless of the country of residency although the FAW tended to have higher rates of central obesity while the FW tended to have higher rates of risk-associated HDL levels. Further research should examine the cause of these differences in order to develop better cardiovascular screening and intervention strategies.

Analyzing speckle contrast for HiLo microscopy optimization

Science.gov (United States)

Mazzaferri, J.; Kunik, D.; Belisle, J. M.; Singh, K.; Lefrançois, S.; Costantino, S.

2011-07-01

HiLo microscopy is a recently developed technique that provides both optical sectioning and fast imaging with a simple implementation and at a very low cost. The methodology combines widefield and speckled illumination images to obtain one optically sectioned image. Hence, the characteristics of such speckle illumination ultimately determine the quality of HiLo images and the overall performance of the method. In this work, we study how speckle contrast influence local variations of fluorescence intensity and brightness profiles of thick samples. We present this article as a guide to adjust the parameters of the system for optimizing the capabilities of this novel technology.

Lo que dijo Casimiro Eiger de Ramírez

Directory of Open Access Journals (Sweden)

Casimiro Eiger

1995-01-01

Full Text Available La evolución de los artistas colombianos -si en este caso puede hablarse de evolución y no, más bien, de una transformación artificial- procede generalmente por saltos, por bruscas metamorfosis, por inconcebibles cambios. Los artistas nacionales no tienen, por lo general, la paciencia de esperar que unos procesos interiores de que tienen una vaga conciencia maduren en ellos, lleguen a su punto, se completen y estallen luego en una corona de indudables hazañas. Ellos quieren cosechar las frutas antes de la sazón , y -con tal de presentar algún aspecto insospechado- fuerzan las tendencias incipientes de su propio ser, las obligan a aparecer más definidas de lo que son y se contentan con una fisonomía provisional de lo que, después de unos años de estudio y de tranquila decantación, podría surgir como algo realmente nuevo, persuasivo y poderoso.

El Silencio de la Sirena: lo Sublime en Alejandra Pizarnik

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Julieta Lerman

2012-03-01

Full Text Available http://dx.doi.org/10.5007/1984-784X.2012v12n17p85 Algunas poéticas de las décadas del cincuenta y del sesenta parecerían constituirse en torno a un vacío, un silencio que a veces inspira la palabra poética y otras veces la aborta. Esa ambigüedad, característica de la poética de Alejandra Pizarnik, podemos entenderla como una “reedición” de la estética de lo sublime. Lo sublime es un concepto estético-filosófico que plantearon filósofos como Inmanuel Kant y Edmund Burke para pensar el arte romántico y, en el siglo XX, otros autores como Jean-François Lyotard, lo retomaron para analizar el arte de vanguardia. Así, lo sublime nos permite repensar la poética de Pizarnik en sus coincidencias y oposiciones a otras de la tradición moderna (como la de Charles Baudelaire o de las vanguardias latinoamericanas (como Oliverio Girondo y Vicente Huidobro.

Performance Evaluation of Low Cost LoRa Modules in IoT Applications

Science.gov (United States)

Daud, Shuhaizar; Shi Yang, Teoh; Asmi Romli, Muhamad; Awang Ahmad, Zahari; Mahrom, Norfadila; Raof, Rafikha Aliana A.

2018-03-01

LoRa is a low power long range wireless communication platform that is designed as an efficient communication platform for small, low powered devices. This makes it very suitable for battery powered devices and IoT implementation. This paper evaluates some low cost LoRa modules available on the market and their suitability, energy efficiency and performance during operation. Two low cost LoRa transceiver from Semtech Industries, the SX1272 and SX1278 were tested for their power consumption and maximum transmission range. This study have evaluated the two LoRa solutions and found that the SX1278 have a better transmission range and uses lower energy compared to the SX1272 thus making it more suitable for embedded implementation as a data gateway.

Met1-linked Ubiquitination in Immune Signalling

DEFF Research Database (Denmark)

Fiil, Berthe Katrine; Gyrd-Hansen, Mads

2014-01-01

Methionine 1-linked ubiquitin chains (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. Molecular machinery that assembles, senses and, more recently, disassembles Met1-Ub has been identified, and technical advances have enabled...... identification of physiological substrates for Met1-Ub in response to activation of innate immune receptors. These discoveries have significantly advanced our understanding of how non-degradative ubiquitin modifications control pro-inflammatory responses mediated by nuclear factor κB and mitogen...

LoRa Scalability: A Simulation Model Based on Interference Measurements

Directory of Open Access Journals (Sweden)

Jetmir Haxhibeqiri

2017-05-01

Full Text Available LoRa is a long-range, low power, low bit rate and single-hop wireless communication technology. It is intended to be used in Internet of Things (IoT applications involving battery-powered devices with low throughput requirements. A LoRaWAN network consists of multiple end nodes that communicate with one or more gateways. These gateways act like a transparent bridge towards a common network server. The amount of end devices and their throughput requirements will have an impact on the performance of the LoRaWAN network. This study investigates the scalability in terms of the number of end devices per gateway of single-gateway LoRaWAN deployments. First, we determine the intra-technology interference behavior with two physical end nodes, by checking the impact of an interfering node on a transmitting node. Measurements show that even under concurrent transmission, one of the packets can be received under certain conditions. Based on these measurements, we create a simulation model for assessing the scalability of a single gateway LoRaWAN network. We show that when the number of nodes increases up to 1000 per gateway, the losses will be up to 32%. In such a case, pure Aloha will have around 90% losses. However, when the duty cycle of the application layer becomes lower than the allowed radio duty cycle of 1%, losses will be even lower. We also show network scalability simulation results for some IoT use cases based on real data.

G-LoSA for Prediction of Protein-Ligand Binding Sites and Structures.

Science.gov (United States)

Lee, Hui Sun; Im, Wonpil

2017-01-01

Recent advances in high-throughput structure determination and computational protein structure prediction have significantly enriched the universe of protein structure. However, there is still a large gap between the number of available protein structures and that of proteins with annotated function in high accuracy. Computational structure-based protein function prediction has emerged to reduce this knowledge gap. The identification of a ligand binding site and its structure is critical to the determination of a protein's molecular function. We present a computational methodology for predicting small molecule ligand binding site and ligand structure using G-LoSA, our protein local structure alignment and similarity measurement tool. All the computational procedures described here can be easily implemented using G-LoSA Toolkit, a package of standalone software programs and preprocessed PDB structure libraries. G-LoSA and G-LoSA Toolkit are freely available to academic users at http://compbio.lehigh.edu/GLoSA . We also illustrate a case study to show the potential of our template-based approach harnessing G-LoSA for protein function prediction.

Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks

DEFF Research Database (Denmark)

Dodds, Chris M; Henson, Richard N; Suckling, John

2013-01-01

It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activatio...

Hydrogen storage capacity of titanium met-cars

International Nuclear Information System (INIS)

Akman, N; Durgun, E; Yildirim, T; Ciraci, S

2006-01-01

The adsorption of hydrogen molecules on the titanium metallocarbohedryne (met-car) cluster has been investigated by using the first-principles plane wave method. We have found that, while a single Ti atom at the corner can bind up to three hydrogen molecules, a single Ti atom on the surface of the cluster can bind only one hydrogen molecule. Accordingly, a Ti 8 C 12 met-car can bind up to 16 H 2 molecules and hence can be considered as a high-capacity hydrogen storage medium. Strong interaction between two met-car clusters leading to the dimer formation can affect H 2 storage capacity slightly. Increasing the storage capacity by directly inserting H 2 into the met-car or by functionalizing it with an Na atom have been explored. It is found that the insertion of neither an H 2 molecule nor an Na atom could further promote the H 2 storage capacity of a Ti 8 C 12 cluster. We have also tested the stability of the H 2 -adsorbed Ti 8 C 12 met-car with ab initio molecular dynamics calculations which have been carried out at room temperature

Tamoxifen-loaded lecithin organogel (LO) for topical application: Development, optimization and characterization.

Science.gov (United States)

Bhatia, Amit; Singh, Bhupinder; Raza, Kaisar; Wadhwa, Sheetu; Katare, Om Prakash

2013-02-28

Lecithin organogels (LOs) are semi-solid systems with immobilized organic liquid phase in 3-D network of self-assembled gelators. This paper attempts to study the various attributes of LOs, starting from selection of materials, optimization of influential components to LO specific characterization. After screening of various components (type of gelators, organic and aqueous phase) and construction of phase diagrams, a D-optimal mixture design was employed for the systematic optimization of the LO composition. The response surface plots were constructed for various response variables, viz. viscosity, gel strength, spreadability and consistency index. The optimized LO composition was searched employing overlay plots. Subsequent validation of the optimization study employing check-point formulations, located using grid search, indicated high degree of prognostic ability of the experimental design. The optimized formulation was characterized for morphology, drug content, rheology, spreadability, pH, phase transition temperatures, and physical and chemical stability. The outcomes of the study were interesting showing high dependence of LO attributes on the type and amount of phospholipid, Poloxamer™, auxillary gelators and organic solvent. The optimized LO was found to be quite stable, easily applicable and biocompatible. The findings of the study can be utilized for the development of LO systems of other drugs for the safer and effective topical delivery. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Is neurofeedback effectief bij kinderen met ADHD?

NARCIS (Netherlands)

de Hen, M.H.; Geurts, H.M.

2008-01-01

Kan neurofeedback verantwoord ingezet worden bij de behandeling van kinderen met ADHD? Omdeze vraag te beantwoorden worden zeven recente onderzoeken naar de effectiviteit van neurofeedback bij kinderen met ADHD geanalyseerd. Ondanks dat de resultaten in eerste instantie lijken te suggereren dat

Proef met duurzaam watergebruik in de bollenstreek

NARCIS (Netherlands)

Fliegenthart, F.; Dik, P.E.; Groenendijk, P.

2009-01-01

In 2007 begon in de Wieringermeer een praktijkproef met alternatieve waterbeheersystemen voor de bollenteelt. Met drie verschillende teeltsystemen wordt onderzoek verricht naar zo optimaal mogelijk gebruik van zoet water door recirculatie en hergebruik. Ook loopt onderzoek naar de emissie van

Sediment transport on the Palos Verdes shelf, California

Science.gov (United States)

Ferre, B.; Sherwood, C.R.; Wiberg, P.L.

2010-01-01

Sediment transport and the potential for erosion or deposition have been investigated on the Palos Verdes (PV) and San Pedro shelves in southern California to help assess the fate of an effluent-affected deposit contaminated with DDT and PCBs. Bottom boundary layer measurements at two 60-m sites in spring 2004 were used to set model parameters and evaluate a one-dimensional (vertical) model of local, steady-state resuspension, and suspended-sediment transport. The model demonstrated skill (Brier scores up to 0.75) reproducing the magnitudes of bottom shear stress, current speeds, and suspended-sediment concentrations measured during an April transport event, but the model tended to underpredict observed rotation in the bottom-boundary layer, possibly because the model did not account for the effects of temperature-salinity stratification. The model was run with wave input estimated from a nearby buoy and current input from four to six years of measurements at thirteen sites on the 35- and 65-m isobaths on the PV and San Pedro shelves. Sediment characteristics and erodibility were based on gentle wet-sieve analysis and erosion-chamber measurements. Modeled flow and sediment transport were mostly alongshelf toward the northwest on the PV shelf with a significant offshore component. The 95th percentile of bottom shear stresses ranged from 0.09 to 0.16 Pa at the 65-m sites, and the lowest values were in the middle of the PV shelf, near the Whites Point sewage outfalls where the effluent-affected layer is thickest. Long-term mean transport rates varied from 0.9 to 4.8 metric tons m-1 yr-1 along the 65-m isobaths on the PV shelf, and were much higher at the 35-m sites. Gradients in modeled alongshore transport rates suggest that, in the absence of a supply of sediment from the outfalls or PV coast, erosion at rates of ???0.2 mm yr-1 might occur in the region southeast of the outfalls. These rates are small compared to some estimates of background natural sedimentation

A survey on LPWA technology: LoRa and NB-IoT

Directory of Open Access Journals (Sweden)

Rashmi Sharan Sinha

2017-03-01

Full Text Available By 2020, more than twenty five billion devices would be connected through wireless communications. In accordance with the rapid growth of the internet of things (IoT market, low power wide area (LPWA technologies have become popular. In various LPWA technologies, narrowband (NB-IoT and long range (LoRa are two leading technologies. In this paper, we provide a comprehensive survey on NB-IoT and LoRa as efficient solutions connecting the devices. It is shown that unlicensed LoRa has advantages in terms of battery lifetime, capacity, and cost. Meanwhile, licensed NB-IoT offers benefits in terms of QoS, latency, reliability, and range.

Razón y Fortuna (José M.ª González, La diosa Fortuna. Metamorfosis de una metáfora política

Directory of Open Access Journals (Sweden)

Ruano de la Fuente, Yolanda

2007-12-01

Full Text Available Establishing a dialogue with last José M. González’s book, La diosa Fortuna. Metamorfosis de una metáfora política, awarded with the National Prize of Essay 2007, the present article is focused on analysing relations kept by Reason to what historically uses to appear as its perfect antagonist: Fortune as a synonym of what happens by chance and without control by man’s actions.

En diálogo con el último libro de José M. González, La diosa Fortuna. Metamorfosis de una metáfora política, galardonado con el último Premio Nacional de Ensayo 2007, en este trabajo se analizan las relaciones mantenidas por la Razón con quien históricamente suele aparecer como su perfecto antagonista: La Fortuna, sinónimo de lo azaroso e incontrolable por parte del hombre.

An Improved 6LoWPAN Hierarchical Routing Protocol

Directory of Open Access Journals (Sweden)

Xue Li

2015-10-01

Full Text Available IETF 6LoWPAN working group is engaged in the IPv6 protocol stack research work based on IEEE802.15.4 standard. In this working group, the routing protocol is one of the important research contents. In the 6LoWPAN, HiLow is a well-known layered routing protocol. This paper puts forward an improved hierarchical routing protocol GHiLow by improving HiLow parent node selection and path restoration strategy. GHiLow improves the parent node selection by increasing the choice of parameters. Simutaneously, it also improves path recovery by analysing different situations to recovery path. Therefore, GHiLow contributes to the ehancement of network performance and the decrease of network energy consumption.

Mars MetNet Mission Pressure and Humidity Devices

Science.gov (United States)

Haukka, H.; Harri, A.-M.; Schmidt, W.; Genzer, M.; Polkko, J.; Kemppinen, O.; Leinonen, J.

2012-09-01

A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). MetBaro and MetHumi are part of the scientific payload of the MNL. Main scientific goal of both devices is to measure the meteorological phenomena (pressure and humidity) of the Martian atmosphere and complement the previous Mars mission atmospheric measurements (Viking and Phoenix) for better understanding of the Martian atmospheric conditions.

Aptamers Binding to c-Met Inhibiting Tumor Cell Migration.

Directory of Open Access Journals (Sweden)

Birgit Piater

Full Text Available The human receptor tyrosine kinase c-Met plays an important role in the control of critical cellular processes. Since c-Met is frequently over expressed or deregulated in human malignancies, blocking its activation is of special interest for therapy. In normal conditions, the c-Met receptor is activated by its bivalent ligand hepatocyte growth factor (HGF. Also bivalent antibodies can activate the receptor by cross linking, limiting therapeutic applications. We report the generation of the RNA aptamer CLN64 containing 2'-fluoro pyrimidine modifications by systematic evolution of ligands by exponential enrichment (SELEX. CLN64 and a previously described single-stranded DNA (ssDNA aptamer CLN3 exhibited high specificities and affinities to recombinant and cellular expressed c-Met. Both aptamers effectively inhibited HGF-dependent c-Met activation, signaling and cell migration. We showed that these aptamers did not induce c-Met activation, revealing an advantage over bivalent therapeutic molecules. Both aptamers were shown to bind overlapping epitopes but only CLN3 competed with HGF binding to cMet. In addition to their therapeutic and diagnostic potential, CLN3 and CLN64 aptamers exhibit valuable tools to further understand the structural and functional basis for c-Met activation or inhibition by synthetic ligands and their interplay with HGF binding.

Scalability analysis of large-scale LoRaWAN networks in ns-3

OpenAIRE

Abeele, Floris Van den; Haxhibeqiri, Jetmir; Moerman, Ingrid; Hoebeke, Jeroen

2017-01-01

As LoRaWAN networks are actively being deployed in the field, it is important to comprehend the limitations of this Low Power Wide Area Network technology. Previous work has raised questions in terms of the scalability and capacity of LoRaWAN networks as the number of end devices grows to hundreds or thousands per gateway. Some works have modeled LoRaWAN networks as pure ALOHA networks, which fails to capture important characteristics such as the capture effect and the effects of interference...

75 FR 61478 - D'Lo Gas Storage, LLC; Notice of Petition

Science.gov (United States)

2010-10-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP10-504-000] D'Lo Gas Storage, LLC; Notice of Petition September 24, 2010. Take notice that on September 21, 2010, D'Lo Gas.... CP10-504-000, a petition for an Exemption of Temporary Acts and Operations and Request for Expedited...

A first-in-human phase I study of SAR125844, a selective MET tyrosine kinase inhibitor, in patients with advanced solid tumours with MET amplification.

Science.gov (United States)

Angevin, Eric; Spitaleri, Gianluca; Rodon, Jordi; Dotti, Katia; Isambert, Nicolas; Salvagni, Stefania; Moreno, Victor; Assadourian, Sylvie; Gomez, Corinne; Harnois, Marzia; Hollebecque, Antoine; Azaro, Analia; Hervieu, Alice; Rihawi, Karim; De Marinis, Filippo

2017-12-01

Dysregulated MET signalling is implicated in oncogenesis. The safety and preliminary efficacy of a highly selective MET kinase inhibitor (SAR125844) was investigated in patients with advanced solid tumours and MET dysregulation. This was a phase I dose-escalation (3 + 3 design [50-740 mg/m 2 ]) and dose-expansion study. In the dose escalation, patients had high total MET (t-MET) expression by immunohistochemistry (IHC) or MET amplification by fluorescence in situ hybridisation. In the dose expansion, patients had MET amplification (including a subset of patients with non-small cell lung cancer [NSCLC]) or phosphorylated-MET (p-MET) expression (IHC). Objectives were determination of maximum tolerated dose (MTD) of once-weekly intravenous SAR125844 based on dose-limiting toxicities; safety and pharmacokinetic profile; preliminary efficacy of SAR125844 MTD in the expansion cohort. In total, 72 patients were enrolled: dose escalation, N = 33; dose expansion, N = 39; 570 mg/m 2 was established as the MTD. Most frequent treatment-emergent adverse events (AEs) were asthenia/fatigue (58.3%), nausea (31.9%), and abdominal pain, constipation, and dyspnea (27.8% for each); 58.3% of patients reported grade 3 AEs (19.4% were treatment related). Of the 29 evaluable patients with MET amplification treated at 570 mg/m 2 , five achieved a partial response, including four of 22 with NSCLC; 17 patients had stable disease. No response was observed in patients with high p-MET solid tumours. There was no correlation between tumour response and t-MET status or MET gene copy number. The MTD of once-weekly SAR125844 was 570 mg/m 2 ; SAR125844 was well tolerated, with significant antitumour activity in patients with MET-amplified NSCLC. NCT01391533. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

¿Lo aprecias o lo odias? Tus gestos al hablar pueden delatarte

Directory of Open Access Journals (Sweden)

Miriam Sicre Márquez

2017-06-01

Full Text Available Los diestros tienden a valorar positivamente la derecha y los zurdos la izquierda. En un estudio reciente se analizaron los gestos que acompañaban los discursos de los candidatos a presidente de EE.UU. John Kerry y George Bush (ambos diestros en las elecciones de 2004, y de John McCain y Barack Obama (ambos zurdos en las de 2008. Los candidatos diestros usaron más la mano derecha cuando hablaban de cosas positivas y la mano izquierda para cosas negativas, en tanto que los zurdos hicieron lo contrario. Esto revela un vínculo hasta ahora desconocido entre la lateralidad manual, los gestos expresivos y la emoción.

Effective implementation of novel MET pharmacodynamic assays in translational studies.

Science.gov (United States)

Srivastava, Apurva K; Navas, Tony; Herrick, William G; Hollingshead, Melinda G; Bottaro, Donald P; Doroshow, James H; Parchment, Ralph E

2017-01-01

MET tyrosine kinase (TK) dysregulation is significantly implicated in many types of cancer. Despite over 20 years of drug development to target MET in cancers, a pure anti-MET therapeutic has not yet received market approval. The failure of two recently concluded phase III trials point to a major weakness in biomarker strategies to identify patients who will benefit most from MET therapies. The capability to interrogate oncogenic mutations in MET via circulating tumor DNA (ctDNA) provides an important advancement in identification and stratification of patients for MET therapy. However, a wide range in type and frequency of these mutations suggest there is a need to carefully link these mutations to MET dysregulation, at least in proof-of-concept studies. In this review, we elaborate how we can utilize recently developed and validated pharmacodynamic biomarkers of MET not only to show target engagement, but more importantly to quantitatively measure MET dysregulation in tumor tissues. The MET assay endpoints provide evidence of both canonical and non-canonical MET signaling, can be used as "effect markers" to define biologically effective doses (BEDs) for molecularly targeted drugs, confirm mechanism-of-action in testing combination of drugs, and establish whether a diagnostic test is reporting MET dysregulation. We have established standard operating procedures for tumor biopsy collections to control pre-analytical variables that have produced valid results in proof-of-concept studies. The reagents and procedures are made available to the research community for potential implementation on multiple platforms such as ELISA, quantitative immunofluorescence assay (qIFA), and immuno-MRM assays.

Disposal alternatives and recommendations for waste salt management for repository excavation in the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

1987-01-01

This report documents an evaluation of five alternatives for the disposal of waste salt that would be generated by the construction of a repository for radioactive waste in underground salt deposits at either of two sites in the Palo Duro Basin, Texas. The alternatives include commercial disposal, offsite deep-well injection, disposal in abandoned mines, ocean disposal, and land surface disposal on or off the site. For each alternative a reference case was rated - positive, neutral, or negative - in terms of environmental and dependability factors developed specifically for Texas sites. The factors constituting the environmental checklist relate to water quality impact, water- and land-use conflicts, ecological compatibility, conformity with air quality standards, and aesthetic impact. Factors on the dependability check-list relate to public acceptance, the adequacy of site characterization, permit and licensing requirements, technological requirements, and operational availability. A comparison of the ratings yielded the following viable alternatives, in order of preference: (1) land surface disposal, specifically disposal on tailings piles associated with abandoned potash mines; (2) disposal in abandoned mines, specifically potash mines; and (3) commercial disposal. Approaches to the further study of these three salt management techniques are recommended

When Historiography Met Epistemology

Directory of Open Access Journals (Sweden)

Jean-François Stoffel

2017-06-01

Full Text Available Review of Bordoni, Stefano. When historiography met epistemology: Sophisticated histories and philosophies of science in French-speaking countries in the second half of the nineteenth century. Reviewed by Jean-François Stoffel.

Intrusion Detection and light weight Firewall for the 6LoWPAN networks

OpenAIRE

Shreenivas, Dharmini

2014-01-01

IPv6 over Low power WPAN (6loWPAN) is an adaption layer introduced between the link layer and the network layer in the TCP/IP protocol stack to t the IPv6 datagrams over the IEEE 802.15.4 link layer. 6loWPAN networks comprise of internet enabled resource-constrained smart objects which are interconnected with each other through the Internet Protocol (IPv6). In Internet of Things (IoT), smart devices of the 6loWPAN networks are connected to the unsecured public Internet. RPL (Routing Protocol ...

Evaluación oxidativa de las mezclas de aceites de leguminosas del Desierto de Sonora con aceites de maíz y soja durante su almacenamiento

Directory of Open Access Journals (Sweden)

Vázquez-Moreno, L.

2001-12-01

por lo que se consideró de interés evaluar el proceso de oxidación durante el almacenamiento por 122 días de mezclas en los aceites de: Mezquite Prosopis juliflora, Gatuña Mimosa grahamii, Palo fierro Olneya tesota, Vinorama Acacia constricta, Palo de brea Cercidium praecox y Palo verde Parkinsonia aculeata con aceites de soja y maíz en proporciones 1:1, 2:1 y 3:1. Los parámetros evaluados fueron: Indice de Peróxidos (I.P, de yodo (I.I, de Acidez (I.A, así como el valor de p-Anisidina (p-A. Las mezclas de los aceites silvestres con el de maíz mostraron valores iniciales de I.P. en un rango de 2 a 4 meq/Kg y a los 122 días el valor fue de 4 a 7 meq/Kg mientras que las mezclas con el aceite de soja los valores iniciales fueron de 3 a 6 meq/Kg y al final fueron de 8 a 15 meq/Kg. Los valores de I.I. e I.A. no presentaron diferencias entre las mezclas de los aceites silvestres con el de maíz. Los aceites silvestres mezclados con el de soja incrementaron el I.I. en las tres proporciones estudiadas, y en el I.A. presentaron un ligero incremento en la proporción 1:1. En el valor de p-Anisidina de las mezclas de aceites silvestres con maíz se obtuvo un pequeño aumento el cual fue menor en las mezclas 3:1, a diferencia de las mezclas con aceite de soja el incremento fue mayor y solo en las mezclas con aceite de gatuña y palo fierro los valores menores se observaron en las mezclas 3:1. Los aceites de gatuña y palo fierro mezclados con aceite de maíz presentaron los menores incrementos en los índices de oxidación evaluados. Los aceites de palo fierro y gatuña mezclados con aceite de maíz no presentaron cambios en la concentración de ácidos palmítico y araquidico du rante el almacenamiento. La concentración del ácido oleico en los aceites de mezquite (3:1, gatuña (1:1, 2:1 y 3:1, vinorama (3:1, así como los ácidos linoleico y erucico en gatuña en sus tres mezclas no presentaron cambios ni alteración durante el almacenamiento, por lo que se

Todo lo que se nos brinda...: presentismo y simultaneidad. Fenomenología de lo contemporáneo (collage y saturación

Directory of Open Access Journals (Sweden)

César Moreno Márquez

2012-01-01

Full Text Available Aunque no cabe duda de que el objeto ha sido máximamente relevante como modo de presencia, hay otra modalidad de presencia, no menos decisiva, aunque mucho más desatendida, como es la de simultaneidad de las perspectivas de un objeto (lo que nos conduciría al cubismo y la contemporaneidad de lo heterogéneo (collage. La atención a lo que supusieron, en tal sentido, algunas prácticas de las vanguardias en el primer tercio del siglo XX, puede resultar muy esclarecedora de cara a la investigación de ciertas experiencias que aunque periféricas o monstruosas son imprescindibles no sólo para una ampliación de las posibilidades del pensar fenomenológico, sino también para la profundización de la problemática filosófica de la hipercomunicación, que caracteriza a nuestro entorno civilizatorio. Although there is no doubt that the object has been very relevant as a way of presence, there is another form of presence, no less decisive, though much more disregarded, as is the one of simultaneity of perspectives of an object (which would lead us to cubism and contemporaneity of the heterogeneous (collage. To pay attention to wich they supposed, in such sense, some avant-garde practices in the first third of the twentieth century can be very enlightening in order to research experiences that although peripherals or monstruous, they are essential not only for expanding the possibilities of phenomenological thinking, but also to the deepening of the philosophical problem of hipercomunication, that characterizes our civilizational environment.

Liquid oxygen (LO2) propellant conditioning concept testing

Science.gov (United States)

Perry, Gretchen L. E.; Orth, Michael S.; Mehta, Gopal K.

1993-01-01

Testing of a simplified LO2 propellant conditioning concept for future expendable launch vehicles is discussed. Four different concepts are being investigated: no-bleed, low-bleed, use of a recirculation line, and He bubbling. A full-scale test article, which is a facsimile of a propellant feed duct with an attached section to simulate heat input from an LO2 turbopump, is to be tested at the Cold Flow Facility of the Marshall Space Flight Center West Test Area. Work to date includes: design and fabrication of the test article, design of the test facility and initial fabrication, development of a test matrix and test procedures, initial predictions of test output, and heat leak calibration and heat exchanger tests on the test articles.

Modelización del comportamiento elástico de los polvos metálicos

Directory of Open Access Journals (Sweden)

Riera, M. D.

1998-05-01

Full Text Available In this work the elastic behaviour of metal powders compacted to different densities is studied. The authors apply a model based on the experimental observation that the elastic volumetric strain and the hydrostatic component of the applied stress are exponentially related. While a complete analysis should include both the volumetric and deviatory components of the elastic strain, we only present here the first one.

En este trabajo se estudia el comportamiento a deformación elástica de polvos metálicos compactados hasta distintas densidades, mediante ensayos de compresión uniaxial en carga y descarga aplicados sobre los compactos. Se aplica un modelo fenomenológico que relaciona exponencialmente la deformación volumétrica elástica y la componente hidrostática de la tensión. Aunque un análisis completo debería incluir la deformación elástica desviadora, aquí sólo se presenta la componente volumétrica.

La experiencia cultural de lo sagrado a través de la geometría de los albores de la humanidad hasta la aritmosofía de Pitágoras

Directory of Open Access Journals (Sweden)

Óscar Castro García

2015-03-01

Full Text Available La Geometría llamada «Sagrada» es una metáfora de la Ordenación del Universo, la huella digital de la Creación. Este es un estudio interdisciplinar donde se ofrece información sobre diversas materias que van desde teoría de la estética, historia del arte, hasta la mecánica cuántica, pasando por la simbólica, la antropología de las religiones, la microbiología y la cosmología. El interés de este estudio es la visión heurística y transdisciplinar que se proyecta sobre un conocimiento perenne y holístico del sentido de la geometría como una semiótica de lo sagrado en la vida. Comenzamos nuestro camino en los albores de la humanidad, en la que la geometría estaba vinculada con la posibilidad de comunicación. Sobre todo de forma que su semiótica no fuese únicamente fuente de gestión social y económica. Sobre todo hay una fuerte motivación de comunicación con lo tremendo, lo magnífico, lo inefable y lo sagrado (Mircea Eliade, o «lo santo» (Rudolf Otto. Veremos cómo dicha vinculación semiótico-simbólica adquiere cada vez mayor complejidad, aunque su grado de abstracción ya es sutil desde el neolítico. Lo complejo viene en la aplicación de la matemática geométrica a la arquitectura (desde los megalitos hasta los templos y pirámides, pasando por los zigurats y sus operaciones mágicas, teúrgicas y místicas. Nos concentraremos en ver algunas características de las construcciones hasta llegar a Pitágoras de Samos en cuya escuela de geometría se vive una edad de oro, en el sentido pleromático del conocimiento sapiencial de las matemáticas: la armonía del número y del ritmo.

Saving energy with paint. Coating with ceramic globules; Energie besparen met verf. Coating met keramische bolletjes

Energy Technology Data Exchange (ETDEWEB)

Willemse, R. [Coateq Coatings, Haarlem (Netherlands)

2011-07-01

The special paint coating of ThermoShield saves energy. The coating consists for 50% of hollow, vacuum ceramic globules. The waterborne damp-open coating with capillary function resists rain water and removes redundant water in case of draught and it reflects sunlight. [Dutch] Met de speciale verfcoating ThermoShield kan energie worden bespaard. De coating bestaat voor 50% uit holle, vacuum getrokken keramische bolletjes. De watergedragen damp-open coating met capillaire werking stoot bij regen water af en voert bij droogte overtollig vocht af en reflecteert zonlicht.

Tecnologías informáticas: herramientas, metáforas y espacios culturales de investigación

Directory of Open Access Journals (Sweden)

Rocío Rueda Ortiz

2003-04-01

Full Text Available Uno de los cuestionamientos actuales a la investigación cualitativa tiene que ver con su potencial para describir adecuadamente la complejidad del mundo social contemporáneo. Dos aspectos son por lo menos llamados a redefinirse: los objetos de estudio, y los modos y medios de recolección y presentación de información. En primer lugar, se aborda la tensión entre la tecnología como herramienta y como lenguaje, evidenciando las limitaciones y, al mismo tiempo, las posibilidades que ésta ofrece a los estudios cualitativos, en particular, en el uso del hipertexto. En segundo lugar, se analiza el ciberespacio como una realidad emergente, como escenario social objeto de investigación y como una nueva metáfora para comprender el tránsito hacia teorías sociales de conocimiento mucho más complejas.

Groen proceswater: zuivering brouwerijprocesafvalwater met microalgen : Resultaten onderzoek 2013

NARCIS (Netherlands)

Dijk, van W.; Diem, van A.; Doornbusch, P.; Grobben-Gaastra, S.A.; Kleinhout, G.; Kroon, A.; Weide, van der R.Y.

2014-01-01

Afgelopen jaar is de pilot met het kweken van algen met afvalwater van de brouwerijlocatie Zoeterwoude geslaagd. Dit is gedaan in een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR-Acrres. Dit is de eerste inline pilot in de wereld waarbij met LED verlichting op 1000 L

Widefield fluorescence sectioning with HiLo microscopy.

Science.gov (United States)

Mertz, Jerome; Lim, Daryl; Chu, Kengyeh K; Bozinovic, Nenad; Ford, Timothy

2009-01-01

HiLo microscopy is a widefield fluorescence imaging technique that provides depth discrimination by combining two images, one with non-uniform illumination and one with uniform illumination. We discuss the theory of this technique and a variety of practical implementations in brain-tissue imaging and fluorescence endomicroscopy.

Noliktavu vadības sistēmas (WMS) ieviešana un ieviešanas rezultātu analīze loģistikas uzņēmumā AS ,,Dominante Loģistikas Sistēma

OpenAIRE

Morozovs, Gļebs

2010-01-01

Darbā „Noliktavu vadības sistēmas (WMS) ieviešana un ieviešanas rezultātu analīze loģistikas uzņēmumā AS „Dominante Loģistikas Sistēma„ tiek pētīta noliktavu vadības sistēmas ievešanas ietekme uz loģistikas uzņēmumu. Darbā izpētīts loģistikas saturs un funkcionālās sfēra, aplūkoti noliktavu un transporta loģistika pamatprincipi un mijiedarbība, analizētas loģistikas attīstības tendences un loma Latvijas tautsaimniecība. Izpētīti noliktavu un transporta loģistikas instrumenti, raksturota infor...

Otra vez hablando de lo que habla

Directory of Open Access Journals (Sweden)

García Calvo, Agustín

2011-02-01

Full Text Available Reconociendo la contradicción que se da entre la lengua DE que se habla y la lengua EN que se habla, se trata de hacer sentir al lector la inmensa complejidad de la máquina de la lengua, que nos pasa casi enteramente desapercibida. Para entender esto es preciso darse cuenta de que el artilugio de la lengua se encuentra en un nivel sub-conciente, común, que no pertenece a nadie. Hablamos así de bien gracias a que no nos damos cuenta de lo que hacemos cuando hablamos. Esto se ilustra negativamente con varios fenómenos lingüísticos bien conocidos: la pronunciación pedante de ciertas palabras, las alternancias “se me cayó” / ”me se cayó” y otras, etc., además de hacer ver lo inútil de empeñarse en pronunciar a conciencia los fonemas estraños de la lengua que uno aprende.

Fast optically sectioned fluorescence HiLo endomicroscopy

Science.gov (United States)

Ford, Tim N.; Lim, Daryl; Mertz, Jerome

2012-02-01

We describe a nonscanning, fiber bundle endomicroscope that performs optically sectioned fluorescence imaging with fast frame rates and real-time processing. Our sectioning technique is based on HiLo imaging, wherein two widefield images are acquired under uniform and structured illumination and numerically processed to reject out-of-focus background. This work is an improvement upon an earlier demonstration of widefield optical sectioning through a flexible fiber bundle. The improved device features lateral and axial resolutions of 2.6 and 17 μm, respectively, a net frame rate of 9.5 Hz obtained by real-time image processing with a graphics processing unit (GPU) and significantly reduced motion artifacts obtained by the use of a double-shutter camera. We demonstrate the performance of our system with optically sectioned images and videos of a fluorescently labeled chorioallantoic membrane (CAM) in the developing G. gallus embryo. HiLo endomicroscopy is a candidate technique for low-cost, high-speed clinical optical biopsies.

Efficacy of c-Met inhibitor for advanced prostate cancer

International Nuclear Information System (INIS)

Tu, William H; Zhu, Chunfang; Clark, Curtis; Christensen, James G; Sun, Zijie

2010-01-01

Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuation of androgen receptor (AR) signalling. This suggested that current androgen ablation therapy for prostate cancer activates c-Met expression and may contribute to development of more aggressive, castration resistant prostate cancer (CRPC). Therefore, we directly assessed the efficacy of c-Met inhibition during androgen ablation on the growth and progression of prostate cancer. We tested two c-Met small molecule inhibitors, PHA-665752 and PF-2341066, for anti-proliferative activity by MTS assay and cell proliferation assay on human prostate cancer cell lines with different levels of androgen sensitivity. We also used renal subcapsular and castrated orthotopic xenograft mouse models to assess the effect of the inhibitors on prostate tumor formation and progression. We demonstrated a dose-dependent inhibitory effect of PHA-665752 and PF-2341066 on the proliferation of human prostate cancer cells and the phosphorylation of c-Met. The effect on cell proliferation was stronger in androgen insensitive cells. The c-Met inhibitor, PF-2341066, significantly reduced growth of prostate tumor cells in the renal subcapsular mouse model and the castrated orthotopic mouse model. The effect on cell proliferation was greater following castration. The c-Met inhibitors demonstrated anti-proliferative efficacy when combined with androgen ablation therapy for advanced prostate cancer

Visualidades y materialidades de lo digital: caminos desde la antropología

Directory of Open Access Journals (Sweden)

Elisenda Ardèvol

2014-01-01

Full Text Available En este artículo presentamos una reflexión sobre cómo estudiamos lo digital desde una perspectiva antropológica y exploramos cómo se han planteado cuestiones como la diversidad cultural, las desigualdades sociales y las posibilidades de cambio y transformación social vinculadas con las tecnologías digitales. Proponemos que es necesario abrir un debate sobre las conceptualizaciones de lo digital y cuáles son las categorías que utilizamos para describir los procesos de cambio y continuidad en lo cotidiano, así como el papel de las tecnologías en ellos. este planteamiento nos lleva a cuestionarnos cómo los etnógrafos y etnógrafas hemos explorado las complejas relaciones entre las prácticas locales, los tránsitos globales y las tecnologías digitales; para ello, abordamos algunos caminos que ha tomado el abordaje de los aspectos materiales y visuales de lo digital en la creación cultural y en los medios de comunicación y nos preguntamos sobre la manera en que incorporamos lo digital en nuestra propia práctica etnográfica y producción de conocimiento antropológico.

LoRa scalability : a simulation model based on interference measurements

OpenAIRE

Haxhibeqiri, Jetmir; Van den Abeele, Floris; Moerman, Ingrid; Hoebeke, Jeroen

2017-01-01

LoRa is a long-range, low power, low bit rate and single-hop wireless communication technology. It is intended to be used in Internet of Things (IoT) applications involving battery-powered devices with low throughput requirements. A LoRaWAN network consists of multiple end nodes that communicate with one or more gateways. These gateways act like a transparent bridge towards a common network server. The amount of end devices and their throughput requirements will have an impact on the performa...

A protective effect of the BDNF Met/Met genotype in obesity in healthy Caucasian subjects but not in patients with coronary heart disease.

Science.gov (United States)

Sustar, A; Nikolac Perkovic, M; Nedic Erjavec, G; Svob Strac, D; Pivac, N

2016-08-01

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor with an important role in the regulation of body weight, body mass index (BMI) and obesity. Increased BMI that leads to obesity is a substantial risk factor for coronary heart disease (CHD). The functional BDNF Val66Met polymorphism (rs6265) has been associated with CHD, obesity and BMI. The aim of the study was to determine the association between BDNF rs6265 polymorphism and CHD and/or BMI in patients with CHD and healthy control subjects. The study included 704 Caucasian subjects: 206 subjects with CHD and 498 healthy control subjects. The BDNF rs6265 genotype frequency was similar in male and female subjects, and there were no differences in the frequency of the BDNF rs6265 genotypes in 206 patients with CHD and in 498 healthy subjects. When study participants were subdivided according to the BMI categories into normal weight, overweight and obese subjects, significantly different BDNF rs6265 genotype frequency was found within healthy subjects, but not within patients with CHD. Healthy subjects, but not patients with CHD, subdivided into carriers of the Met/Met, Met/Val and Val/Val genotype, had different BMI scores. The BDNF rs6265 genotype frequency was similar in male and female subjects, and there were no differences in the frequency of the BDNF rs6265 genotypes in 206 patients with CHD and in 498 healthy subjects. When study participants were subdivided according to the BMI categories into normal weight, overweight and obese subjects, significantly different BDNF rs6265 genotype frequency was found within healthy subjects, but not within patients with CHD. Healthy subjects, but not patients with CHD, subdivided into carriers of the Met/Met, Met/Val and Val/Val genotype, had different BMI scores. BDNF rs6265 polymorphism was not associated with a diagnosis of CHD or with BMI categories among patients with CHD. In contrast, healthy Caucasians, carriers of the BDNF Met/Met genotype, had more

El sentido de lo femenino: sobre la admiración y la diferencia sexual

Directory of Open Access Journals (Sweden)

Catherine Malabou

2009-01-01

Full Text Available En este artículo se exponen una serie de cuestiones que plantean el marco y la extensión de lo que se entiende por lo femenino, así como su papel en lo que respecta a la diferencia sexual y al género, desvinculándolo de las mujeres. A través de un recorrido por el pensamiento de distintos autores que han trabajado el concepto de lo femenino, tales como Levinas, Derrida, Heidegger e Irigaray, se analiza el concepto de admiración cartesiano como advenimiento del otro. Lo femenino reconoce además el cuerpo de la mujer y su múltiple sexualidad encarnada por sus múltiples labios, según la imagen de Irigaray, en su paso hacia una identidad metabólica y en tránsito.

Mars MetNet Mission - Martian Atmospheric Observational Post Network

Science.gov (United States)

Hari, Ari-Matti; Haukka, Harri; Aleksashkin, Sergey; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Siikonen, Timo; Palin, Matti

2017-04-01

A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Strawman Scientific Payload The strawman payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: - MetBaro Pressure device - MetHumi Humidity device - MetTemp Temperature sensors Optical devices: - PanCam Panoramic - MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer - DS Dust sensor Composition and Structure Devices: Tri-axial magnetometer MOURA Tri-axial System Accelerometer The descent processes dynamic properties are monitored by a special 3-axis

La intimidad y la experiencia en lo público

Directory of Open Access Journals (Sweden)

María Teresa Luna

2007-05-01

Full Text Available Esta investigación, de corte fenomenológico, se posiciona en los postulados de la fenomenología del mundo social desarrollada por Alfred Schütz; en este sentido se discute la categoría intimidad como experiencia subjetiva en la que se vivencia la configuración del yo y el tú, y en la que se producen y decantan significaciones esenciales para la relación con uno mismo o con una misma, y con los otros u otras, lo cual parece producir esquemas de actuación en lo público, entendido como el espacio físico y simbólico compartido con otros mediatos u otras mediatas. La información fue construida mediante entrevistas conversacionales en las que cuatro profesionales (tres mujeres y un hombre, vinculados a Organizaciones No Gubernamentales de la ciudad de Medellín con un fuerte trabajo en lo público, construyeron narrativas autobiográficas. La unidad de lectura de la información fue el relato –entendido como una historia con un principio, un desarrollo y un final–y el criterio de selección de relatos significativos fue el acontecimiento biográfico, entendido como un evento que produce un quiebre en la propia biografía, sea porque rompe algo o inaugura algo. Los acontecimientos seleccionados fueron aquellos que aportaban información pertinente para comprender la progresiva configuración de la experiencia íntima y su encadenamiento con una cierta forma de experienciar la actuación en lo público. Los resultados muestran que la intimidad es experiencia de posicionamiento en asuntos morales que están en la base de la actuación en lo público, así como también que en las relaciones íntimas –básicamente con los contemporáneos inmediatos como los amigos, las amigas y las parejas– se construyen experiencias como la confianza, el cuidado y el respeto, que son determinantes en la manera de transitar por la esfera pública.

La intimidad y la experiencia en lo público

Directory of Open Access Journals (Sweden)

María Teresa Luna C.

2007-01-01

Full Text Available Esta investigación, de corte fenomenológico, se posiciona en los postulados de la fenomenología del mundo social desarrollada por Alfred Schütz; en este sentido se discute la categoría intimidad como experiencia subjetiva en la que se vivencia la configuración del yo y el tú, y en la que se producen y decantan significaciones esenciales para la relación con uno mismo o con una misma, y con los otros u otras, lo cual parece producir esquemas de actuación en lo público, entendido como el espacio físico y simbólico compartido con otros mediatos u otras mediatas. La información fue construida mediante entrevistas conversacionales en las que cuatro profesionales (tres mujeres y un hombre, vinculados a Organizaciones No Gubernamentales de la ciudad de Medellín con un fuerte trabajo en lo público, construyeron narrativas autobiográficas. La unidad de lectura de la información fue el relato –entendido como una historia con un principio, un desarrollo y un final–y el criterio de selección de relatos significativos fue el acontecimiento biográfico, entendido como un evento que produce un quiebre en la propia biografía, sea porque rompe algo o inaugura algo. Los acontecimientos seleccionados fueron aquellos que aportaban información pertinente para comprender la progresiva configuración de la experiencia íntima y su encadenamiento con una cierta forma de experienciar la actuación en lo público. Los resultados muestran que la intimidad es experiencia de posicionamiento en asuntos morales que están en la base de la actuación en lo público, así como también que en las relaciones íntimas –básicamente con los contemporáneos inmediatos como los amigos, las amigas y las parejas– se construyen experiencias como la confianza, el cuidado y el respeto, que son determinantes en la manera de transitar por la esfera pública.

LoRad M IV with stereologic stereotactic system for breast screening and follow-up examinations

International Nuclear Information System (INIS)

1999-01-01

The LoRad M IV mammography unit was assessed clinically by radiological staff at the West Suffolk Hospital Breast Screening Unit, Bury St Edmonds for screening and assessment, and at the South East Scotland Breast Screening Centre for screening only. A full technical assessment was made in September 1998 by Physics staff from KCARE at Bury St Edmonds. The unit was physically assessed as an assessment mammography unit. The physical checks indicated that the unit met the requirements of MDA/95/40 with the following notable exceptions: The x-ray tube current is less than 100 ma at 28 kV. The available range of mAs is less than the recommended levels. The 'preparation' delay is over 1 second. Exposures can be made with the cassette out of position. The magnification factor is less than 1.8 x. The lead equivalent should be marked on the protective screen. Some of these points of non compliance will have no relevance for some applications. It is necessary that prospective purchasers should be aware of them even though they are not reflected in adverse comment by the assessors

Enhancing LoRaWAN Security through a Lightweight and Authenticated Key Management Approach.

Science.gov (United States)

Sanchez-Iborra, Ramon; Sánchez-Gómez, Jesús; Pérez, Salvador; Fernández, Pedro J; Santa, José; Hernández-Ramos, José L; Skarmeta, Antonio F

2018-06-05

Luckily, new communication technologies and protocols are nowadays designed considering security issues. A clear example of this can be found in the Internet of Things (IoT) field, a quite recent area where communication technologies such as ZigBee or IPv6 over Low power Wireless Personal Area Networks (6LoWPAN) already include security features to guarantee authentication, confidentiality and integrity. More recent technologies are Low-Power Wide-Area Networks (LP-WAN), which also consider security, but present initial approaches that can be further improved. An example of this can be found in Long Range (LoRa) and its layer-two supporter LoRa Wide Area Network (LoRaWAN), which include a security scheme based on pre-shared cryptographic material lacking flexibility when a key update is necessary. Because of this, in this work, we evaluate the security vulnerabilities of LoRaWAN in the area of key management and propose different alternative schemes. Concretely, the application of an approach based on the recently specified Ephemeral Diffie⁻Hellman Over COSE (EDHOC) is found as a convenient solution, given its flexibility in the update of session keys, its low computational cost and the limited message exchanges needed. A comparative conceptual analysis considering the overhead of different security schemes for LoRaWAN is carried out in order to evaluate their benefits in the challenging area of LP-WAN.

LoRa IoT -radion soveltuvuus käytettyjen työkoneiden tiedonsiirtoon

OpenAIRE

Hasu, Lassi

2017-01-01

Opinnäytetyön tarkoituksena oli tutkia LoRa-radiotekniikan soveltuvuutta lastinkäsittelylaitteiden tuottaman datan tiedonsiirtoon. LoRa on teollisen internetin sovelluksia varten kehitetty pitkän kantaman radiotekniikka. Tavoitteena oli löytää käyttötapauksia, joihin LoRa-tekniikka soveltuu etsittäessä kustannustehokasta radiotekniikkaa erityisesti käytettyihin lastinkäsittelylaitteisiin. Työn toimeksiantaja oli Cargotec Finland Oy:n Kalmar-liiketoimintayksikkö. Työn tutkimusmenetelmänä käyte...

Studeren met Hans Rosenberg

NARCIS (Netherlands)

Rutten, R.J.

2001-01-01

Hoe was het om in de jaren zestig te studeren? Laat ik een terugblik ophangen aan een studiemakker, Hans Rosenberg. We vormden samen de sterrekundejaar- gang 1961. Hans studeerde af in 1966 met hoofdvak wiskunde, promoveerde op radiostralingsprocessen in de zonnecorona in 1973, verliet de

Higher Levels of c-Met Expression and Phosphorylation Identify Cell Lines With Increased Sensitivity to AMG-458, a Novel Selective c-Met Inhibitor With Radiosensitizing Effects

International Nuclear Information System (INIS)

Li Bo; Torossian, Artour; Sun, Yunguang; Du, Ruihong; Dicker, Adam P.; Lu Bo

2012-01-01

Purpose: c-Met is overexpressed in some non-small cell lung cancer (NSCLC) cell lines and tissues. Cell lines with higher levels of c-Met expression and phosphorylation depend on this receptor for survival. We studied the effects of AMG-458 on 2 NSCLC cell lines. Methods and Materials: 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium assays assessed the sensitivities of the cells to AMG-458. Clonogenic survival assays illustrated the radiosensitizing effects of AMG-458. Western blot for cleaved caspase 3 measured apoptosis. Immunoblotting for c-Met, phospho-Met (p-Met), Akt/p-Akt, and Erk/p-Erk was performed to observe downstream signaling. Results: AMG-458 enhanced radiosensitivity in H441 but not in A549. H441 showed constitutive phosphorylation of c-Met. A549 expressed low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment was found to synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. Conclusions: AMG-458 was more effective in cells that expressed higher levels of c-Met/p-Met, suggesting that higher levels of c-Met and p-Met in NSCLC tissue may classify a subset of tumors that are more sensitive to molecular therapies against this receptor.

Klimaatverandering en de stadsboom (interview met Jitze Kopinga)

NARCIS (Netherlands)

Bennink, P.; Kopinga, J.

2010-01-01

Bomen in de stad staan vaak op warme plaatsen met een gebrekkige waterhuishouding. Volgens het KNMI zal Nederland in de toekomst steeds vaker met hitte en droogte te maken hebben. Wat betekent dat voor onze stadsbomen?

MetNet Network Mission for Martian Atmospheric Investigations

Science.gov (United States)

Harri, A.-M.; Alexashkin, S.; Arrugeo, I.; Schmidt, W.; Vazquez, L.; Genzer, M.; Haukka, H.

2014-07-01

A new kind of planetary exploration mission for Mars called MetNet is being developed for martian atmospheric investigations. The eventual scope of the MetNet Mission is to deploy tens of small landers on the martian surface.

Requirements to be met by the operation manual

International Nuclear Information System (INIS)

1981-03-01

The rule applies to the contents and the lay-out of the operating manual for stationary nuclear power plants. The draft contains: 1. General requirement to be met by the contents of the operating manual. The operating manual to be arranged in 4 parts (part 1: internal rules and regulations; part 2: operation overall plant; part 3: incidents; part 4: operation systems). Safety specifications to be included in the manual, the exemption being the system of technical documentation. 2. General requirements to be met by the lay-out of the operating manual. Comprehensibility; legibility; structure and subdivisions; arrangement of the instructions and design of the manuals cover. 3. Requirements to be met by part 1. Defining the various internal rules and regulations (personnel management); rules and regulations concerning inspections and shift work; maintenance and repair; radiation protection; guard duty and admission; alarm; fire protection; first aid. 4. Requirements to be met by part 2. Provisions and operational limitations; limit values important from the point of view of safety; normal operation; anomalous operation; in-service inspections. 6. Requirements to be met by part 3. 7. Annex: Rules, regulations and stipulations mentioned in the rule draft. (orig.)

Constitutive parameters for salt and nonsalt rocks from the Detten, G. Friemel, and Zeeck wells in the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Senseny, P.E.; Pfeifle, T.W.; Mellegard, K.D.

1985-01-01

Results are presented from laboratory tests performed on salt and nonsalt rocks from the Palo Duro Basin in Texas. The Unit 5 salt from the Lower San Andres is assumed to be the repository horizon and is more completely characterized than other strata. For the Unit 5 salt, values are given for the parameters in the exponential-time constitutive law that models the time-independent elastic deformation and the time-dependent inelastic deformation. Both linear and nonlinear failure envelopes for this salt at 20 0 C are also determined. Data reported for twenty other salt and nonsalt horizons include tangent moduli and principal strain ratios, as well as linear failure envelopes at 20 0 C. The matrix of tests performed is adequate for conceptual repository design and performance analysis. However, final repository design and performance analysis requires more extensive characterization of the constitutive behavior of the stratigraphy, especially the repository-horizon salt

La familia: Desde lo tradicional a lo discutible

Directory of Open Access Journals (Sweden)

María Elena Benítez Pérez

2017-12-01

Full Text Available Una de las pocas generalizaciones ampliamente aceptadas en las ciencias sociales es que la familia es una institución que se encuentra en todas las sociedades humanas. Esta sintetiza la congruencia entre los cambios económicos, políticos, sociales, culturales y demográficos que tienen lugar en los países. Su desarrollo no es anárquico, sino que responde a las transformaciones experimentadas por la sociedad a la que representa. Por tanto, aunque sigue siendo la institución van surgiendo nuevas modalidades de relaciones entre padres e hijos, entre hombres y mujeres, entre jóvenes y viejos que conducen, sin duda, a otros modelos familiares. El presente artículo tiene como objetivo debatir acerca del concepto de familia tradicional –pareja heterosexual, con hijos y con roles bien definidos–, frente a otras estructuras familiares contemporáneas que alteran los parámetros con los que se entendía la vida familiar. Para ello, se propone transitar por algunas definiciones que permiten reflexionar en torno a los principales cambios observados en la sociedad y su reflejo en la perspectiva analítica de la familia como institución, en particular, lo referido al matrimonio y la cohabitación, la procreación y la filiación intergeneracional.

Dimensionering van de Uniqfill chemischer wasser met lamellen

NARCIS (Netherlands)

Starmans, D.A.J.

2006-01-01

In dit rapport wordt een eerste aanzet gegeven tot de modellering van een kruisstroom chemische wasser met lamellen. Met behulp van bestaande metingen is de stofoverdrachtscoëfficiënt afgeschat, waarna scenario's voor nieuwe wassers doorgerekend konden worden.

LO APEIRON: VOZ DE GRECIA CLÁSICA EN LA CIENCIA CONTEMPORÁNEA

Directory of Open Access Journals (Sweden)

ROMÁN CASTAÑEDA-SEPULVEDA

2012-07-01

Full Text Available Se analiza el paralelo entre lo apeiron, designado por Anaximandro como arche cósmico y las concepciones sobre el universo derivadas de los desarrollos científicos, particularmente del siglo XX. Este análisis sugiere la vigencia del pensamiento de Anaximandro, quien lo promulgó hace 26 siglos.

MET overexpression, gene amplification and relevant clinicopathological features in gastric adenocarcinoma.

Science.gov (United States)

Zhang, Jing; Guo, Lei; Liu, Xiuyun; Li, Wenbin; Ying, Jianming

2017-02-07

This study was conducted to investigate the expression of MET in Chinese gastric adenocarcinoma cohort, the correlation between MET overexpression and clinical pathological features, HER2 expression and MET gene amplification. A total of 816 gastric adenocarcinoma patients were included and MET and HER2 immunohistochemical (IHC) staining were performed. IHC and dual-color silver in situ hybridization analysis were performed in the tissue microarrays, constructed from the 240 patients who were randomly selected. MET overexpression (IHC 3+) was observed in 6.0% (49/816) of the cohort. MET overexpression rate was higher in patients with poor prognostic factors, such as clinical stages III/IV (p =0.012) and pathologic stages T3/T4 (p =0.027). The HER2 overexpression (IHC 3+) rate was 8.8% (72/816) and MET overexpression rate was higher in HER2 positive patients (9.7%, 7/72). A high concordance rate (94.6%) between MET overexpression and gene amplification was demonstrated. Therefore, MET overexpression could serve as a prognostic biomarker and a potential therapeutic target for gastric cancer.

Enhancing LoRaWAN Security through a Lightweight and Authenticated Key Management Approach

Directory of Open Access Journals (Sweden)

Ramon Sanchez-Iborra

2018-06-01

Full Text Available Luckily, new communication technologies and protocols are nowadays designed considering security issues. A clear example of this can be found in the Internet of Things (IoT field, a quite recent area where communication technologies such as ZigBee or IPv6 over Low power Wireless Personal Area Networks (6LoWPAN already include security features to guarantee authentication, confidentiality and integrity. More recent technologies are Low-Power Wide-Area Networks (LP-WAN, which also consider security, but present initial approaches that can be further improved. An example of this can be found in Long Range (LoRa and its layer-two supporter LoRa Wide Area Network (LoRaWAN, which include a security scheme based on pre-shared cryptographic material lacking flexibility when a key update is necessary. Because of this, in this work, we evaluate the security vulnerabilities of LoRaWAN in the area of key management and propose different alternative schemes. Concretely, the application of an approach based on the recently specified Ephemeral Diffie–Hellman Over COSE (EDHOC is found as a convenient solution, given its flexibility in the update of session keys, its low computational cost and the limited message exchanges needed. A comparative conceptual analysis considering the overhead of different security schemes for LoRaWAN is carried out in order to evaluate their benefits in the challenging area of LP-WAN.

Mindfulness voor volwassenen met een licht verstandelijke beperking

NARCIS (Netherlands)

Punt, M.; Helmond, P.E.; Meirmans, M.; Otten, R.; Speckens, A.E.M.

2016-01-01

Mensen met een licht verstandelijke beperking (LVB) hebben veelal te maken met een opeenstapeling van verschillende biologische, psychologische en sociale factoren, waardoor zij vijf tot zes keer meer kans hebben op het ontwikkelen van psychopathologie dan normaal begaafden (Allen, 2008; Buckles,

Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice.

Science.gov (United States)

Li, Wen-Jing; Yu, Hui; Yang, Jian-Min; Gao, Jing; Jiang, Hong; Feng, Min; Zhao, Yu-Xia; Chen, Zhe-Yu

2010-08-06

Brain-derived neurotrophic factor (BDNF) has been reported to play important roles in the modulation of anxiety, mood stabilizers, and pathophysiology of affective disorders. Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. The humanized BDNF(Met/Met) knock-in transgenic mice exhibited increased anxiety-related behaviors that were unresponsive to serotonin reuptake inhibitors, fluoxetine. Music is known to be able to elicit emotional changes, including anxiolytic effects. In this study, we found that music treatment could significantly decrease anxiety state in BDNF(Met/Met) mice, but not in BDNF(+/)(-), mice compared with white noise exposure in open field and elevated plus maze test. Moreover, in contrast to white noise exposure, BDNF expression levels in the prefrontal cortex (PFC), amygdala and hippocampus were significantly increased in music-exposed adult BDNF(Met/Met) mice. However, music treatment could not upregulate BDNF levels in the PFC, amygdala, and hippocampus in BDNF(+/)(-) mice, which suggests the essential role of BDNF in the anxiolytic effect of music. Together, our results imply that music may provide an effective therapeutic intervention for anxiety disorders in humans with this genetic BDNF(Met) variant. Copyright 2010 Elsevier B.V. All rights reserved.

LoFASM: A Low Frequency All Sky Monitor for Radio Transients and Student Training

Science.gov (United States)

2015-09-02

SECURITY CLASSIFICATION OF: The Low-Frequency All- Sky Monitor (LoFASM) is an innovative new radio astronomy observatory. Designed and built by...Feb-2015 Approved for Public Release; Distribution Unlimited Final Report: LoFASM: A Low Frequency All Sky Monitor for Radio Transients and Student...reviewed journals: Number of Papers published in non peer-reviewed journals: Final Report: LoFASM: A Low Frequency All Sky Monitor for Radio Transients and

Preproghrelin Leu72Met polymorphism in obese Korean children.

Science.gov (United States)

Jo, Dae-Sun; Kim, Se-Lim; Kim, Sun-Young; Hwang, Pyoung Han; Lee, Kee-Hyoung; Lee, Dae-Yeol

2005-11-01

Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

Effect of MET on formation and vigor of wheat roots

International Nuclear Information System (INIS)

Wang Bingkui; Jin Ziyu; Zhao Miaozhen; Zhao Yanshen

1993-01-01

Effect of MET on the formation and vigor of roots of wheat seedlings were studied. The results showed that 50 ∼ 200 ppm MET inhibited vertical elongation of roots, increased root, shoot ratio and enhanced the formation and vigor of roots. But MET had no effect on the dry weight of roots. The activity of peroxidase was decreased and the proportion of assimilates in roots was increased by MET treatment compared with the control

Lo siniestro del enigma.

Directory of Open Access Journals (Sweden)

Victoria Eugenia Diaz.

1999-11-01

Full Text Available En "El nacimiento de la filosofía griega", Giorgio Colli nos muestra una faceta tenebrosa del enigma. El dios Apolo, de naturaleza ilimitada, insondable, caprichosa, plantea al hombre enigmas que lo enfrentan con el sufrimiento y con la muerte. Allí, Edipo se confronta con enigmas enviados por el dios en los que se pone en juego su propia existencia. Tiempo después, en el transcurrir del siglo XX, reaparece una nueva forma de este dios arbitrario y arrogante: el desaparecedor de personas, ese inmoderado que impone moderación, borra con su acto un cuerpo, una imagen, un nombre, y formula un nuevo enigma siniestro que enfrenta otra vez al hombre con el dolor y con la muerte.

Interband optical absorption in the Wannier-Stark ladder under the electron-LO-phonon resonance condition

International Nuclear Information System (INIS)

Govorov, A.O.

1993-08-01

Interband optical absorption in the Wannier-Stark ladder in the presence of the electron-LO-phonon resonance is investigated theoretically. The electron-LO-phonon resonance occurs when the energy spacing between adjacent Stark-ladder levels coincides with the LO-phonon energy. We propose a model describing the polaron effect in a superlattice. Calculations show that the absorption line shape is strongly modified due to the polaron effect under the electron-LO-phonon resonance condition. We consider optical phenomena in a normal magnetic field that leads to enhancement of polaron effects. (author). 17 refs, 5 figs

Keystone Life Orientation (LO) teachers: implications for educational ...

African Journals Online (AJOL)

have integrity, be trustworthy, resolve conflict and make good use of internal and ... “disadvantages of social context and how these affect learning and ... understanding of keystone LO teachers (Merriam, 1998), what is more it is descriptive, ex ...

Deelname aan de samenleving van mensen met een beperking: participatiemonitor 2007.

NARCIS (Netherlands)

Hoogen, P. van den; Cardol, M.; Speet, M.; Spreeuwenberg, P.; Rijken, M.

2008-01-01

Hoe doen mensen met een beperking mee in de maatschappij? Mensen met een lichamelijke beperking wonen en werken meestal net als iedereen, en ook zij zijn niet altijd tevreden met hun werk. Mensen met een verstandelijke beperking wonen en werken vaak in een speciale omgeving. Het overheidsbeleid

{sup 89}Zr-Onartuzumab PET imaging of c-MET receptor dynamics

Energy Technology Data Exchange (ETDEWEB)

Pool, Martin; Kol, Arjan; Giesen, Danique; Vries, Elisabeth G.E. de [University of Groningen, Department of Medical Oncology, University Medical Center Groningen, Groningen (Netherlands); Terwisscha van Scheltinga, Anton G.T. [University of Groningen, Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen (Netherlands); Lub-de Hooge, Marjolijn N. [University of Groningen, Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen (Netherlands); University of Groningen, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen (Netherlands)

2017-08-15

c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug efficacy or emergence of resistance. Noninvasive visualization of c-MET dynamics could therefore potentially guide c-MET-directed therapies. We investigated the feasibility of {sup 89}Zr-labelled one-armed c-MET antibody onartuzumab PET for detecting relevant changes in c-MET levels induced by c-MET-mediated epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib resistance or heat shock protein-90 (HSP90) inhibitor NVP-AUY-922 treatment in human non-small-cell lung cancer (NSCLC) xenografts. In vitro membrane c-MET levels were determined by flow cytometry. HCC827ErlRes, an erlotinib-resistant clone with c-MET upregulation, was generated from the exon-19 EGFR-mutant human NSCLC cell line HCC827. Mice bearing HCC827 and HCC827ErlRes tumours in opposite flanks underwent {sup 89}Zr-onartuzumab PET scans. The HCC827-xenografted mice underwent {sup 89}Zr-onartuzumab PET scans before treatment and while receiving biweekly intraperitoneal injections of 100 mg/kg NVP-AUY-922 or vehicle. Ex vivo, tumour c-MET immunohistochemistry was correlated with the imaging results. In vitro, membrane c-MET was upregulated in HCC827ErlRes tumours by 213 ± 44% in relation to the level in HCC827 tumours, while c-MET was downregulated by 69 ± 9% in HCC827 tumours following treatment with NVP-AUY-922. In vivo, {sup 89}Zr-onartuzumab uptake was 26% higher (P < 0.05) in erlotinib-resistant HCC827ErlRes than in HCC827 xenografts, while HCC827 tumour uptake was 33% lower (P < 0.001) following NVP-AUY-922 treatment. The results show that {sup 89}Zr-onartuzumab PET effectively discriminates relevant changes in c-MET levels and could potentially be used clinically to monitor c-MET status. (orig.)

Juegos de Palo en Lara. Elementos para la historia social de un arte marcial venezolano

Directory of Open Access Journals (Sweden)

Röhrig Assunção, Matthias

1999-04-01

Full Text Available This article situates Venezuelan stick fighting among the wider field of European and Afro-American martial arts. The author analyses the different forms used since the early 19th century by men in the rural areas of the state of Lara, where it is still practised today. Whereas the Juego de Garrote serves recreational and sportive purposes, the Juego de Batalla is part of a broader devotion to Saint Anthony. The criminal records show how the use of the fighting stick in the period 1880-1930 allowed the construction of a male identity (the «guapo» through the frequent fights between men.

Este trabajo intenta situar a los juegos de palo venezolanos dentro de una perspectiva más amplia de las artes marciales europeas y afro-americanas. Analiza las diferentes modalidades practicadas desde el siglo XIX por los hombres del campo en Lara, Estado donde se conservó su práctica hasta hoy en día. Mientras el Juego de Garrote servía y sirve para fines recreativos y deportivos, el Juego de Batalla era y es parte de la devoción a San Antonio. Los procesos criminales muestran cómo el uso del garrote permitió la construcción de una identidad masculina («el guapo» a través de las frecuentes riñas entre hombres en el período 1880-1930.

EDUCACIÓN SEXUAL MÁS ALLÁ DE LO BIOLÓGICO

Directory of Open Access Journals (Sweden)

María José Rivera Otero

2016-10-01

Full Text Available Tradicionalmente la educación sexual ha tenido un enfoque reduccionista, orientado hacia lo informativo-preventivo y bajo unaperspectiva conceptual biologizante, y se ha dejado de lado los aspectos sociales, culturales, valóricos y de sexo-género. Para superaresta visión, se propuso como objetivo identificar y caracterizar los modelos estudiantiles después de una intervención didáctica enfocada en la reflexión, el análisis y la toma de decisiones en casos de aprendizaje que abordaban el contenido de infecciones detransmisión sexual (its. A partir de los resultados se encontraron tres modelos: biológico, afectivo y social, lo que demuestra la necesidad de abordar la educación sexual de manera integral y considerar la noción de género como eje fundamental para discutir en torno a los conocimientos, actitudes y prácticas relativas a lo que significa ser hombre o ser mujer en la sociedad actual.

The CEA−/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells

Science.gov (United States)

Zhang, Bo; Mu, Lei; Huang, Kaiyu; Zhao, Hui; Ma, Chensen; Li, Xiaolan; Tao, Deding; Gong, Jianping; Qin, Jichao

2016-01-01

Serum carcinoembryonic antigen (CEA) is the most commonly used tumor marker in a variety of cancers including colorectal cancer (CRC) for tumor diagnosis and monitoring. Recent studies have shown that colonic crypt cells expressing little or no CEA may enrich for stem cells. Numerous studies have clearly shown that there exist CRC patients with normal serum CEA levels during tumor progression or even tumor relapse, although CEA itself is considered to promote metastasis and block cell differentiation. These seemingly contradictory observations prompted us to investigate, herein, the biological properties as well as tumorigenic and metastatic capacity of CRC cells that express high (CEA+) versus low CEA (CEA−/lo) levels of CEA. Our findings show that the abundance of CEA−/lo cells correlate with poor differentiation and poor prognosis, and moreover, CEA−/lo cells form more spheres in vitro, generate more tumors and exhibit a higher potential in developing liver and lung metastases than corresponding CEA+ cells. Applying RNAi-mediated approach, we found that IGF1R mediated tumorigenic and capacity of CEA−/lo cells but did not mediate those of CEA+ cells. Notably, our data demonstrated that CEA molecule was capable of protecting CEA−/lo cells from anoikis, implying that CEA+ cells, although themselves possessing less tumorigenic and metastatic capacity, may promote metastasis of CEA−/lo cells via secreting CEA molecule. Our observations suggest that, besides targeting CEA molecule, CEA−/lo cells may represent a critical source of tumor progression and metastasis, and should therefore be the target of future therapies. PMID:27813496

Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

Science.gov (United States)

Yuen, Hiu-Fung; Chan, Ka-Kui; Platt-Higgins, Angela; Dakir, El-Habib; Matchett, Kyle B.; Haggag, Yusuf Ahmed; Jithesh, Puthen V.; Habib, Tanwir; Faheem, Ahmed; Dean, Fennell A.; Morgan, Richard; Rudland, Philip S.; El-Tanani, Mohamed

2016-01-01

It has been shown previously that cancer cells with an activated oncogenic pathway, including Met activation, require Ran for growth and survival. Here, we show that knockdown of Ran leads to a reduction of Met receptor expression in several breast and lung cancer cell lines. This, in turn suppressed HGF expression and the Met-mediated activation of the Akt pathway, as well as cell adhesion, migration, and invasion. In a cell line model where Met amplification has previously been shown to contribute to gefitinib resistance, Ran knockdown sensitized cells to gefitinib-mediated inhibition of Akt and ERK1/2 phosphorylation and consequently reduced cell proliferation. We further demonstrate that Met reduction-mediated by knockdown of Ran, occurs at the post-transcriptional level, probably via a matrix metalloproteinase. Moreover, the level of immunoreactive Ran and Met are positively associated in human breast cancer specimens, suggesting that a high level of Ran may be a pre-requisite for Met overexpression. Interestingly, a high level of immunoreactive Ran dictates the prognostic significance of Met, indicating that the co-overexpression of Met and Ran may be associated with cancer progression and could be used in combination as a prognostic indicator. PMID:27716616

Met .naturalis in zee: Nederlands koraalrifonderzoek in de Indo-Pacific

NARCIS (Netherlands)

Hoeksema, B.W.

2003-01-01

In een serie arikelen onder de naam 'Met Naturalis in zee', zal Onderwatersport in samenwerking met het Leidse museum Naturalis met enige regelmaat aandacht besteden aan Nederlands biologisch koraalrifonderzoek in de Indische en de Stille Oceaan. Bert Hoeksema schreef de introductie van de serie.

Lo sano y lo enfermo. El consumo de vinos y los problemas sociales del alcoholismo en el Montevideo del novecientos

Directory of Open Access Journals (Sweden)

Daniela Bouret

2013-04-01

Full Text Available En Uruguay existe un creciente consumo de drogas cuyas consecuencias negativas son visibles en los siniestros laborales, de tránsito y en el recrudecimiento de la violencia doméstica y delictiva. Este tema es considerado asunto de Estado y se entiende el alcohol como la primera droga de inicio (incluye la ingesta de vino. Nos interesa analizar el vínculo entre medicina y moral que, desde el Novecientos, ha pautado la relación del consumo de alcohol entre lo «saludable» o lo «excesivo». En esa atmósfera de creciente higienismo se desarrolló, sin embargo, una industria vitivinícola con éxito. En este artículo buscamos desnaturalizar los discursos médicos como construcción histórica y sus consecuencias en el cuerpo de los alcohólicos en espacios de reclusión (hospitales y cárceles y en la sociedad del Montevideo en el Novecientos.

Effects of the BDNF Val66Met Polymorphism and Met Allele Load on Declarative Memory Related Neural Networks

OpenAIRE

Dodds, Chris M.; Henson, Richard N.; Suckling, John; Miskowiak, Kamilla W.; Ooi, Cinly; Tait, Roger; Soltesz, Fruzsina; Lawrence, Phil; Bentley, Graham; Maltby, Kay; Skeggs, Andrew; Miller, Sam R.; McHugh, Simon; Bullmore, Edward T.; Nathan, Pradeep J.

2013-01-01

It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including...

Deelname aan de samenleving van mensen met een beperking: participatiemonitor 2007.

OpenAIRE

Hoogen, P. van den; Cardol, M.; Speet, M.; Spreeuwenberg, P.; Rijken, M.

2008-01-01

Hoe doen mensen met een beperking mee in de maatschappij? Mensen met een lichamelijke beperking wonen en werken meestal net als iedereen, en ook zij zijn niet altijd tevreden met hun werk. Mensen met een verstandelijke beperking wonen en werken vaak in een speciale omgeving. Het overheidsbeleid is erop gericht dat iedereen – dus ook mensen met een beperking – zoveel mogelijk ‘gewoon mee kan doen’ in de maatschappij. Bijvoorbeeld werken bij een gewone werkgever, schoolgaan op een gewone school...

Radiation Chemical Studies of Gly-Met-Gly in Aqueous Solution

NARCIS (Netherlands)

Barata-Vallejo, Sebastian; Ferreri, Carla; Zhang, Tao; Permentier, Hjalmar; Bischoff, Rainer; Bobrowski, Krzysztof; Chatgilialoglu, Chryssostomos

2016-01-01

Important biological consequences are related to the reaction of HO(•) radicals with methionine (Met). Several fundamental aspects remain to be defined when Met is an amino acid residue incorporated in the interior of peptides and proteins. The present study focuses on Gly-Met-Gly, the simplest

Lack of neural compensatory mechanisms of BDNF val66met met carriers and APOE E4 carriers in healthy aging, mild cognitive impairment, and Alzheimer's disease.

Science.gov (United States)

Gomar, Jesus J; Conejero-Goldberg, Concepcion; Huey, Edward D; Davies, Peter; Goldberg, Terry E

2016-03-01

Compromises in compensatory neurobiologic mechanisms due to aging and/or genetic factors (i.e., APOE gene) may influence brain-derived neurotrophic factor (BDNF) val66met polymorphism effects on temporal lobe morphometry and memory performance. We studied 2 cohorts from Alzheimer's Disease Neuroimaging Initiative: 175 healthy subjects and 222 with prodromal and established Alzheimer's disease. Yearly structural magnetic resonance imaging and cognitive performance assessments were carried out over 3 years of follow-up. Both cohorts had similar BDNF Val/Val and Met allele carriers' (including both Val/Met and Met/Met individuals) distribution. In healthy subjects, a significant trend for thinner posterior cingulate and precuneus cortices was detected in Met carriers compared to Val homozygotes in APOE E4 carriers, with large and medium effect sizes, respectively. The mild cognitive impairment/Alzheimer's disease cohort showed a longitudinal decline in entorhinal thickness in BDNF Met carriers compared to Val/Val in APOE E4 carriers, with effect sizes ranging from medium to large. In addition, an effect of BDNF genotype was found in APOE E4 carriers for episodic memory (logical memory and ADAS-Cog) and semantic fluency measures, with Met carriers performing worse in all cases. These findings suggest a lack of compensatory mechanisms in BDNF Met carriers and APOE E4 carriers in healthy and pathological aging. Copyright © 2016 Elsevier Inc. All rights reserved.

Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach

Directory of Open Access Journals (Sweden)

Motohide Hori

2016-06-01

Full Text Available Lavender oil (LO is a commonly used essential oil in aromatherapy as non-traditional medicine. With an aim to demonstrate LO effects on the body, we have recently established an animal model investigating the influence of orally administered LO in rat tissues, genome-wide. In this brief, we investigate the effect of LO ingestion in the blood of rat. Rats were administered LO at usual therapeutic dose (5 mg/kg in humans, and following collection of the venous blood from the heart and extraction of total RNA, the differentially expressed genes were screened using a 4 × 44-K whole-genome rat chip (Agilent microarray platform; Agilent Technologies, Palo Alto, CA, USA in conjunction with a two-color dye-swap approach. A total of 834 differentially expressed genes in the blood were identified: 362 up-regulated and 472 down-regulated. These genes were functionally categorized using bioinformatics tools. The gene expression inventory of rat blood transcriptome under LO, a first report, has been deposited into the Gene Expression Omnibus (GEO: GSE67499. The data will be a valuable resource in examining the effects of natural products, and which could also serve as a human model for further functional analysis and investigation.

Corporeidad y significado: naturaleza dual de lo físico

OpenAIRE

Arranz Rodrigo, Marceliano

2015-01-01

La información es una dimensión de lo real que, a pesar de no tener natu-raleza física, solo existe apoyada en una base física. Y su presencia en los objetos, eventos y procesos que constituyen nuestro entorno vital humano, es lo que permite que el mundo sea inteligible. Sin información no serían posibles las definiciones, ni el pensamiento, ni el lenguaje, ni la ciencia. La importancia de la información está creciendo de manera expo-nencial en nuestros días. Aclarar su estatuto ...

El urbanismo contra lo urbano. La ciudad y la vida urbana en Henri Lefebvre

Directory of Open Access Journals (Sweden)

Manuel Delgado Ruiz

2018-01-01

Full Text Available Henri Lefebvre coloca en el eje de su teoría sobre la vida urbana la oposición entre el espacio vivido por quienes lo usan o sueñan y el espacio abstracto que creen organizar los tecnócratas de la ciudad, que raramente reconocen hasta qué punto su “creatividad” está sometida a intereses privados o institucionales. Tras ese espacio hipotético sobre el que urbanistas y arquitectos trabajan no hay otra cosa que mera ideología, es decir, fantasma que recubre y disfraza las relaciones sociales reales de producción. Frente -o de espaldas- a ese orden espacial meramente teórico de los “especialistas”, lo que las ciudades conocen es la actividad constante o inminente de lo urbano, entendido como apoteosis y exacerbación de lo social, dinamismo siempre activado de acontecimientos y quehaceres sobre el que los “expertos” aplican planes y proyectos, pero del que no saben en realidad nada, acaso por lo cual pugnan por anularlo.

Dephasing of LO-phonon-plasmon hybrid modes in n-type GaAs

Science.gov (United States)

Vallée, F.; Ganikhanov, F.; Bogani, F.

1997-11-01

The relaxation dynamics of coherent phononlike LO-phonon-plasmon hybrid modes is investigated in n-doped GaAs using an infrared time-resolved coherent anti-Stokes Raman scattering technique. Measurements performed for different crystal temperatures in the range 10-300 K as a function of the electron density injected by doping show a large reduction of the hybrid mode dephasing time compared to the bare LO-phonon one for densities larger than 1016 cm-3. The results are interpreted in terms of coherent decay of the LO-phonon-plasmon mixed mode in the weak-coupling regime and yield information on the plasmon and electron relaxation. The estimated average electron momentum relaxation times are smaller than those deduced from Hall mobility measurements, as expected from our theoretical model.

Performance Evaluation of LoRa Considering Scenario Conditions.

Science.gov (United States)

Sanchez-Iborra, Ramon; Sanchez-Gomez, Jesus; Ballesta-Viñas, Juan; Cano, Maria-Dolores; Skarmeta, Antonio F

2018-03-03

New verticals within the Internet of Things (IoT) paradigm such as smart cities, smart farming, or goods monitoring, among many others, are demanding strong requirements to the Radio Access Network (RAN) in terms of coverage, end-node's power consumption, and scalability. The technologies employed so far to provide IoT scenarios with connectivity, e.g., wireless sensor network and cellular technologies, are not able to simultaneously cope with these three requirements. Thus, a novel solution known as Low Power - Wide Area Network (LP-WAN) has emerged as a promising alternative to provide with low-cost and low-power-consumption connectivity to end-nodes spread in a wide area. Concretely, the Long-Range Wide Area Network (LoRaWAN) technology is one of the LP-WAN platforms that is receiving greater attention from both the industry and the academia. For that reason, in this work, a comprehensive performance evaluation of LoRaWAN under different environmental conditions is presented. The results are obtained from three real scenarios, namely, urban, suburban, and rural, considering both dynamic and static conditions, hence a discussion about the most proper LoRaWAN physical-layer configuration for each scenario is provided. Besides, a theoretical coverage study is also conducted by the use of a radio planning tool considering topographic maps and a precise propagation model. From the attained results, it can be concluded that it is necessary to evaluate the propagation conditions of the deployment scenario prior to the system implantation in order to reach a compromise between the robustness of the network and the transmission data-rate.

A Feasibility Assessment of 6LoWPAN for Secure Communications in the U.S. Army

Science.gov (United States)

2016-06-01

bandwidth. 14. SUBJECT TERMS LoWPAN, 6LoWPAN, 802.15.4, energy , security, feasibility, wireless , networks, range, duration, wireless security...47 Figure 16. Total Energy Expended per Message for Various Data Rates and Transmission Powers...maximize transmission speeds and data throughput pay little concern to energy . This thesis presents a model that assesses 6LoWPAN in both a potential

Ülo Sooster, muna ja Hrushtshov / Ants Juske

Index Scriptorium Estoniae

Juske, Ants, 1956-2016

2006-01-01

Ülo Soosteri ja teiste Moskva avangardistide lootusest pääseda laiema publiku ette ja Hrushtshovi külaskäigul fiaskoga lõppenud näitusest Moskva Maneezhis 1962. aastal. Illustratsiooniks Ü. Soosteri "Valge muna". Õli, pasta, 1968-1970. Tartu Kunstimuuseum

Mars MetNet Mission - Martian Atmospheric Observational Post Network

Science.gov (United States)

Harri, A.-M.; Haukka, H.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Siikonen, T.; Palin, M.

2017-09-01

A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

El acertijo de la metáfora visual

OpenAIRE

De la Rosa Alzate, Adriana; Universidad Autónoma de Occidente

2016-01-01

En este artículo se presentan los resultados de la investigación sobre el proceso de interpretación de la metáfora visual, en niños entre tres y cuatro años de edad. El propósito de la investigación fue dar cuenta del proceso de interpretación de la metáfora visual y del razonamiento involucrado. La metáfora visual se entiende como un fenómeno en el que los objetos representados presentan transformaciones que traen como consecuencia la emergencia de nuevas categorías e incluso la ambigüedad, ...

Resultaten boomkorsurvey 2013: BTS met onderzoeksvaartuigen Isis en Tridens (interview met Ingeborg de Boois)

NARCIS (Netherlands)

Boois, de I.J.

2013-01-01

Van begin augustus tot half september heeft IMARES de boomkorsurvey (BTS) uitgevoerd met de onderzoeksschepen Isis en Tridens. Op 29 maart 2014 wordt een bijeenkomst georganiseerd voor geinteresseerden, waar de resultaten van zowel de BTS als de bedrijfssurvey gepresenteerd worden. De BTS wordt

"Cy Twombly: Intérprete de dos mundos" [Un artista entre Estados Unidos y Europa, entre lo clásico y lo contemporáneo

OpenAIRE

Gras Cruz, Irene

2017-01-01

Esta tesis “Cy Twombly: Intérprete de dos mundos” [Un artista entre Estados Unidos y Europa, entre lo clásico y lo contemporáneo] pretende dar a conocer al artista norteamericano Cy Twombly (1928-2011) en nuestro país y destacar la importancia que tiene dentro del panorama artístico como figura clave en un momento de efervescencia —artística y creativa— americana en el que a diferencia de sus coetáneos prefirió emigrar a Europa, concretamente a Italia. Mientras todos se trasladaban a la nueva...

Caracterización fisicoquímica de los aceites crudos de algunas semillas de leguminosas del desierto sonorense

Directory of Open Access Journals (Sweden)

Ortega-Nieblas, M.

1995-02-01

Full Text Available The Sonoran desert has a great variety of nutritional native plants, mainly from the leguminous family. Although in ancient times their products were used as food by native Americans, there is little information about their potential as a food source. For this reason, oils from the following seeds were studied: Acacia famesiana (huizache, Mimosa grahamii (gatuña, Cercidium microphyilium (palo verde 1, Cercidium sonorae (brea, Parkinsonia aculeata (palo verde 2, Olneya Tesota (palo fierro and Prosopis juliflora (mezquite.
Oils were extracted from the seeds with hexane, and contents ranged from 8.5 to 23.5 %. The physicochemical studies showed mostly unsaturated oils, as demonstrated by the iodine index, (101-147 units. Indexes of acidity, peroxides and free fatty acids were low and within the accepted values. Fatty acids were separated and quantified by gas chromatography. Linoleic and oleic acids were found to predominate. All extracted crude oils were of good quality, comparable to those from soybean, com, sunflower and carthamus.

El desierto de Sonora cuenta con una gran variedad de plantas silvestres principalmente de la familia leguminosae de las cuales se tiene poca información acerca de su potencial como fuente nutricional. Por lo que se estudiaron los aceites de las semillas: Acacia famesiana (huizache, Mimosa grahamii (gatuña, Cercidium microphyilium (palo verde 1, Cercidium sonorae (brea, Parkinsonia aculeata (palo verde 2, Olneya Tesota (palo fierro y Prosopis juliflora (mezquite.
Los aceites de cada semilla se extrajeron con hexano, obteniéndose de 8.5 a 23.5 %. Estos mostraron un alto grado de insaturación reflejado en los índices de lodo, de 101 a 147. Los índices de acidez, peróxidos y ácidos grasos libres fueron bajos y dentro de los valores aceptables. Al cuantificar los ácidos grasos por

Core Follow Calculation for Palo Verde Unit 1 in Cycles 1 through 4 using DeCART2D/MASTER4.0 Code System

International Nuclear Information System (INIS)

Jeong, Hee Jeong; Choi, Yonghee; Kim, Sungmin; Lee, Kyunghoon

2017-01-01

To verify and validate the DeCART2D/MASTER4.0 design system, core follow calculations of Palo Verde Unit 1(PV-1) in cycles 1 through 4 are performed. The calculation results are compared with the measured data and will be used in the generation of bias and uncertainty factors in the DeCART2D/MASTER4.0 design system. The DeCART2D/MASTER codes system has been developed in KAERI for the PWR (Pressurized water reactors) core design including SMRs (Small Modular Reactors). Core follow calculations of Pale Verde Unit 1 in Cycles 1 through 4 have been performed. Reactivities, assembly powers and startup parameters such as EPC, RW, ITC and IBW are compared with the measured data. This work will be used in the generation of bias and uncertainty factors in DeCART2D/MASTER4.0 design system.

La metáfora

DEFF Research Database (Denmark)

Agustin, Oscar Garcia

2007-01-01

2002 y principios de 2003, anteriores a la proclamación de las Juntas de Buen Gobierno. Nuestro objetivo es comprobar cómo las metáforas crean nuevas significaciones, que intentan deshacer una lógica comúnmente asumida, y promover otros modos de comprender la acción y la realidad político-social. Este...

The LoTrach system: its role in the prevention of ventilator-associated pneumonia.

Science.gov (United States)

Fletcher, Andrew J W; Ruffell, Alison J; Young, Peter J

2008-01-01

To discuss the development of the LoTrach system in light of current evidence around the prevention of ventilator-associated pneumonia (VAP) and its practical application in the intensive care setting. VAP causes substantial morbidity and mortality in ventilated patients in the Intensive Care Unit (ICU), increases length of stay in ICU and is extremely costly. Strategies are needed to reduce the risk of VAP. We examine the need for an endotracheal tube (ETT) specifically designed for the critically-ill patient, the development of the LoTrach system from conception to production, and the role of the various components of the system in preventing VAP. Early issues in implementing this revolutionary equipment into ICU are explored and three case studies highlight advantages of this system. The LoTrach system has been designed to facilitate the provision of a number of evidence-based interventions that have been shown to reduce VAP. Pulmonary aspiration is ubiquitous with conventional cuffs but prevented by the cuff of the LoTrach system when held at a constant and safe pressure against the tracheal wall with a cuff pressure controller. Other aspects incorporated in the ETT are aimed at clearing the secretions from the subglottic space, preventing tube occlusion and accidental extubation, and avoiding damage to the airway. In this way the LoTrach system employs a multifactorial approach to the prevention of VAP and the cost savings from LoTrach rather than a standard ETT will be considerable because of an average 3 day reduction in ICU length of stay related to this. It thus has the potential to be a very useful tool in the ICU setting in the prevention of VAP.

Metáforas metalinguísticas de Euclides da Cunha

Directory of Open Access Journals (Sweden)

Carlos Antônio Magalhães Guedelha

2016-03-01

Full Text Available Este artigo apresenta uma leitura das metáforas metalinguísticas do escritor Euclides da Cunha, ou seja, as metáforas que ele utilizou para se referir aos seus dois principais livros, Os Sertões (sobre a guerra de Canudos e Um paraíso perdido (sobre a Amazônia. O conceito de metalinguagem estabelecido por Jakobson foi fundamental para a pesquisa, que teve como suporte teórico básico o postulado da metáfora conceptual, proposta por Lakoff e Johnson. As metáforas analisados neste artigo (VINGAR-SE É ESCREVER e UM LIVRO É UM FILHO foram colhidas de ensaios do escritor e de cartas que ele escreveu a amigos e familiares, “escriturando” a sua escrita por meio da metalinguagem. A análise das metáforas assume, com base em Lakoff e Johnson, que a metáfora não é uma questão apenas de linguagem. Ela é também – e fundamentalmente – uma questão de pensamento e ação.

Globalización y tecnología o el (otro) fin de la nostalgia: realismo y arqueología como metáforas en la última ficción latinoamericana

OpenAIRE

Montoya Juárez, Jesús

2014-01-01

El presente artículo reflexiona acerca del modo en que la tecnología de producción y reproducción de imágenes aparece y contribuye a generar estéticas textovisuales en las narraciones literarias latinoamericanas en tiempos de globalización. Para ello explora como dialogan en los textos las metáforas del realismo y la arqueología, válidas para articular los modos en que la narrativa reciente opera con la tecnología y los medios en el siglo xxi. Lo que los textos literarios que leemos tienen de...

Patrimonio cultural: lo intangible se hace tangible

Directory of Open Access Journals (Sweden)

William Heredia Orjuela

2004-11-01

Full Text Available Se presentan tres reflexiones a manera de ensayo, elaboradas por estudiantes de vii semestre de la Facultad de Administración de Empresas Turísticas y Hoteleras. El tema central que engloba los escritos es el de la responsabilidad frente al patrimonio cultural, su valoración y su relación con el turismo. En el ensayo La protección del patrimonio cultural como reflejo del ser humano, la estudiante cecilia hinosTrosa hace un llamado de atención frente al problema del tráfico ilícito de bienes que conlleva la pérdida de testimonios de la cultura humana. El escrito de la estudiante mariel cecilia hernández destaca las bondades de recuperar las tradiciones y de cómo éstas se pueden difundir a través del turismo. Por último, el estudiante William heredia hace una reflexión sobre la tangibilidad de lo intangible, en el ensayo Patrimonio Cultural: lo tangible se hace intangible, donde destaca la declaratoria del Carnaval de Barranquilla como patrimonio oral e intangible de la humanidad.

El momento de lo vivo: informe del Coloquio de Cerisy

OpenAIRE

Baron , Christine

2016-01-01

International audience; El coloquio El momento de lo vivo, codirigido por Fréderic Worms y Arnaud François, que tuvo lugar en Cerisy del 16 al 23 de agosto de 2012, reunió a filósofos y a científicos; biólogos, médicos, físicos, especialistas en literatura, un historiador, un especialista en ecología y un artista dedicado al trabajo «en vivo» y al que se podría vincular con el bio-arte se concertaron para reflexionar no sobre el concepto de la vida sino sobre lo que ―bajo diversos aspectos― t...

The Influence of Migration on Population Ageing in the Cres-Lošinj Archipelago

Directory of Open Access Journals (Sweden)

Sonja Podgorelec

1999-12-01

Full Text Available Demographic research in regard to the islands of Cres and Lošinj belongs in the domain of small population studies. Throughout history, and especially after World War II, the islands experienced very strong emigration and later immigration processes. After fifty or more years of continual emigration, immigration began on the island of Lošinj in the 1960s, and on Cres in the 1970s. This reversal from strong depopulation to a significant increase in the size of the population, if the islands are examined as a whole, reveals certain demographic particularities in comparison with other Croatian islands. The long-term reduction of the birth rate and prolonged emigration from settlements in the interior of Cres and from all the islands of the Lošinj archipelago has been the cause of many elderly, single-person and abandoned households. All the analytical indicators pertaining to the age structure are above the threshold which marks the beginning of population ageing. The average age on all the islands has for over thirty years been well above 30, whereas in the Lošinj archipelago it has been above the reproductive age – i.e. about 50. The age coefficient varies between 14.02 for Lošinj and 49.22 for Ilovik. The island of Lošinj itself has the youngest population, and hence the lowest indicators of ageing. The burden on the working-age contingent on each island has changed at a different rate and in a different direction during the last three inter-census periods. The co-efficient of dependency of the young is increasing on all the islands, while the co-efficient of dependency of the elderly age groups is falling on Lošinj, Ilovik, Unije and Cres. The reduction of the birth rate and the negative migration balance caused by high emigration of mainly young, unmarried males has caused a seks ratio imbalance in favour of females. The general co-efficient of females, according to the 1991 census was between 105.7 on Lošinj and 145.5 on Unije. The

Fibers and cylinders of cryptomelane-hollandite in Permian bedded salt, Palo Duro Basin, Texas

International Nuclear Information System (INIS)

Belkin, H.E.; Libelo, E.L.

1987-01-01

Fibers and thin-walled, hollow cylinders of cryptomelane-hollandite have been found in both the chevron and the clear salt from various drill cores in Permian bedded salt from the Palo Duro Basin, Texas. The authors have found fibers or cylinders from only the lower San Andres Formation units 4 and 5, the upper San Andres Formation, and the Salado-Transill salt. The fibers are inorganic, light to dark reddish brown, pleochroic, highly birefringent, filamentary single crystals, < 1 to ∼ 5 μm in diameter, with length-to-diameter ratios of at least 20:1. The fibers can be straight and/or curved, can bifurcate, can form loops, waves or spirals, and can be isolated or in parallel groups. Detailed petrographic analyses show no evidence for recrystallization or deformation of the enclosing salt after fiber formation. Although the authors observations do not provide a definitive explanation for fiber origin, they suggest that the fibers grew in situ by a solid-state diffusional process at low temperatures. The cylinders are pleochroic, highly birefringent, light to dark reddish brown, hollow, thin-walled, open-ended right cylinders, having a 1- to 2-μm wall thickness and variable lengths and diameters. There also appear to be single crystals of cryptomelane-hollandite, but these are found almost entirely in fluid inclusions in the chevron and clear salt. Their presence in the primary halite suggests that they were formed contemporaneously with the chevron structure and were accidentally trapped in the fluid inclusions. The observation of cylinders partially or completely enclosed by salt stratigraphically above large fluid inclusions suggests that natural downward fluid-inclusion migration has occurred, in response to the geothermal gradient

Surface dependent behaviour of CdS LO-phonon mode

International Nuclear Information System (INIS)

Molina-Contreras, J R; Medina-Gutierrez, C; Frausto-Reyes, C; Trejo-Vazquez, R; Villalobos-Pina, F J; Romo-Luevano, G; Calixto, S

2007-01-01

In this paper, we develop a sensitive optical method to monitor the surface roughness in the investigation of surfaces. By applying this method to measure the RMS surface roughness of various surfaces, we found RMS values which are comparable to those obtained by atomic force microscopy measurements. In addition, we present a simple empirical model to calculate the RMS surface roughness which shows very good agreement with the surface roughness measurements taken by the method reported in this paper. Finally, the application of our method to the study of the LO-phonon mode of CdS suggests that its intensity is dominated by the surface roughness. This roughness dependent behaviour of the CdS LO-phonon mode is experimentally confirmed by using an excitation wavelength near its E 0 transition

G‐LoSA: An efficient computational tool for local structure‐centric biological studies and drug design

Science.gov (United States)

2016-01-01

Abstract Molecular recognition by protein mostly occurs in a local region on the protein surface. Thus, an efficient computational method for accurate characterization of protein local structural conservation is necessary to better understand biology and drug design. We present a novel local structure alignment tool, G‐LoSA. G‐LoSA aligns protein local structures in a sequence order independent way and provides a GA‐score, a chemical feature‐based and size‐independent structure similarity score. Our benchmark validation shows the robust performance of G‐LoSA to the local structures of diverse sizes and characteristics, demonstrating its universal applicability to local structure‐centric comparative biology studies. In particular, G‐LoSA is highly effective in detecting conserved local regions on the entire surface of a given protein. In addition, the applications of G‐LoSA to identifying template ligands and predicting ligand and protein binding sites illustrate its strong potential for computer‐aided drug design. We hope that G‐LoSA can be a useful computational method for exploring interesting biological problems through large‐scale comparison of protein local structures and facilitating drug discovery research and development. G‐LoSA is freely available to academic users at http://im.compbio.ku.edu/GLoSA/. PMID:26813336

G-LoSA: An efficient computational tool for local structure-centric biological studies and drug design.

Science.gov (United States)

Lee, Hui Sun; Im, Wonpil

2016-04-01

Molecular recognition by protein mostly occurs in a local region on the protein surface. Thus, an efficient computational method for accurate characterization of protein local structural conservation is necessary to better understand biology and drug design. We present a novel local structure alignment tool, G-LoSA. G-LoSA aligns protein local structures in a sequence order independent way and provides a GA-score, a chemical feature-based and size-independent structure similarity score. Our benchmark validation shows the robust performance of G-LoSA to the local structures of diverse sizes and characteristics, demonstrating its universal applicability to local structure-centric comparative biology studies. In particular, G-LoSA is highly effective in detecting conserved local regions on the entire surface of a given protein. In addition, the applications of G-LoSA to identifying template ligands and predicting ligand and protein binding sites illustrate its strong potential for computer-aided drug design. We hope that G-LoSA can be a useful computational method for exploring interesting biological problems through large-scale comparison of protein local structures and facilitating drug discovery research and development. G-LoSA is freely available to academic users at http://im.compbio.ku.edu/GLoSA/. © 2016 The Protein Society.

Polarization dependent behavior of CdS around the first and second LO-phonon modes

International Nuclear Information System (INIS)

Frausto-Reyes, C.; Molina-Contreras, J.R.; Lopez-Alvarez, Y.F.; Medel-Ruiz, C.I.; Perez Ladron de Guevara, H.; Ortiz-Morales, M.

2010-01-01

The present work report studies on resonant Raman experimental line shape for CdS around the first and second LO-phonon modes. The application of our method to the study of LO-phonon modes of CdS suggests that the scattered intensity is dominated by the surface and dependent on polarization. Results showed that the Raman spectra for CdS, roughly fall into three groups: a broad line-wing with apparent maxima around 194 cm -1 in the range of 140 and 240 cm -1 which can be ascribed to overtone scattering from acoustic phonons; a band near the 1LO phonon mode which can be attributed to a combination of one-phonon scattering and peak acoustic phonon and finally, a band near the 2LO phonon mode which can be attributed to a combination of two-phonon scattering and peak acoustic phonon.

Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530)

International Nuclear Information System (INIS)

1984-10-01

Supplement No. 6 to the Safety Evaluation Report for the application filed by Arizona Public Service Company, et al., for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizona, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of (1) additional information submitted by the applicant since Supplement No. 5 was issued and (2) matters that the staff had under review when Supplement No. 5 was issued

Performance Evaluation of LoRa Considering Scenario Conditions

Directory of Open Access Journals (Sweden)

Ramon Sanchez-Iborra

2018-03-01

Full Text Available New verticals within the Internet of Things (IoT paradigm such as smart cities, smart farming, or goods monitoring, among many others, are demanding strong requirements to the Radio Access Network (RAN in terms of coverage, end-node’s power consumption, and scalability. The technologies employed so far to provide IoT scenarios with connectivity, e.g., wireless sensor network and cellular technologies, are not able to simultaneously cope with these three requirements. Thus, a novel solution known as Low Power - Wide Area Network (LP-WAN has emerged as a promising alternative to provide with low-cost and low-power-consumption connectivity to end-nodes spread in a wide area. Concretely, the Long-Range Wide Area Network (LoRaWAN technology is one of the LP-WAN platforms that is receiving greater attention from both the industry and the academia. For that reason, in this work, a comprehensive performance evaluation of LoRaWAN under different environmental conditions is presented. The results are obtained from three real scenarios, namely, urban, suburban, and rural, considering both dynamic and static conditions, hence a discussion about the most proper LoRaWAN physical-layer configuration for each scenario is provided. Besides, a theoretical coverage study is also conducted by the use of a radio planning tool considering topographic maps and a precise propagation model. From the attained results, it can be concluded that it is necessary to evaluate the propagation conditions of the deployment scenario prior to the system implantation in order to reach a compromise between the robustness of the network and the transmission data-rate.

Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin

International Nuclear Information System (INIS)

Yu Yan; Sun Ping; Sun Lichun; Liu Guoyi; Chen Guohua; Shang Lihua; Wu Hongbo; Hu Jing; Li Yue; Mao Yinling; Sui Guangjie; Sun Xiwen

2006-01-01

To investigate the biological effect of mdm2 in human colorectal adenocarcinoma LoVo cells, three mdm2siRNA constructions were recombinated and transient transfected into human colorectal adenocarcinoma LoVo cells with low differentiation character in vitro. The results showed that mdm2siRNA3 reduced mRNA level of mdm2 and protein level of mdm2, leading to proliferation inhibition on LoVo cells, and reduced tumor growth in nude mice. It was found that depletion of MDM2 in this pattern promoted apoptosis of LoVo cells and Cisplatin (DDP) treated in the mdm2siRNA3 transfected cell population would result in a substantial decrease by MTT colorimetry. Decreasing the MDM2 protein level in LoVo cells by RNAi could significantly inhibit tumor growth both in vitro and in vivo, which indicated that mdm2 gene played a definite role in the development and aggressiveness of human colon carcinoma. It also could be a therapeutic target in colorectal carcinoma. The synergistic activation of RNAi and cell toxicity agents indicated that the combination of chemotherapy and gene therapy will be a promising approach in the future

MetReS, an Efficient Database for Genomic Applications.

Science.gov (United States)

Vilaplana, Jordi; Alves, Rui; Solsona, Francesc; Mateo, Jordi; Teixidó, Ivan; Pifarré, Marc

2018-02-01

MetReS (Metabolic Reconstruction Server) is a genomic database that is shared between two software applications that address important biological problems. Biblio-MetReS is a data-mining tool that enables the reconstruction of molecular networks based on automated text-mining analysis of published scientific literature. Homol-MetReS allows functional (re)annotation of proteomes, to properly identify both the individual proteins involved in the processes of interest and their function. The main goal of this work was to identify the areas where the performance of the MetReS database performance could be improved and to test whether this improvement would scale to larger datasets and more complex types of analysis. The study was started with a relational database, MySQL, which is the current database server used by the applications. We also tested the performance of an alternative data-handling framework, Apache Hadoop. Hadoop is currently used for large-scale data processing. We found that this data handling framework is likely to greatly improve the efficiency of the MetReS applications as the dataset and the processing needs increase by several orders of magnitude, as expected to happen in the near future.

Role of Met Axis in Head and Neck Cancer

Energy Technology Data Exchange (ETDEWEB)

Xu, Yiru, E-mail: xuyiru@umich.edu; Fisher, Gary J., E-mail: xuyiru@umich.edu [Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 (United States)

2013-11-26

Head and neck cancer is the sixth most common type of cancer worldwide. Despite advances in aggressive multidisciplinary treatments, the 5-year survival rate for this dreadful disease is only 50%, mostly due to high rate of recurrence and early involvement of regional lymph nodes and subsequent metastasis. Understanding the molecular mechanisms responsible for invasion and metastasis is one of the most pressing goals in the field of head and neck cancer. Met, also known as hepatocyte growth factor receptor (HGFR), is a member of the receptor protein tyrosine kinase (RPTK) family. There is compelling evidence that Met axis is dysregulated and plays important roles in tumorigenesis, progression, metastasis, angiogenesis, and drug resistance in head and neck cancer. We describe in this review current understanding of Met axis in head and neck cancer biology and development of therapeutic inhibitors targeting Met axis.

Simmel y lo "cultura femenina" (Las múltiples lecturas de unos viejos textos

Directory of Open Access Journals (Sweden)

RAQUEL OSBORNE

1987-01-01

Full Text Available Se tratan algunos ensayos de Georg Simmel referentes a la "cuestion femenina". Ensayos que aparecieron originariamente en Philosophische Kultur (Leipzig: Werner Klinkhardt, 1911. Una traducción española de algunos de estos ensayos aparece entre 1923-1925 en la Revista de Occidente, editada por José Ortega y Gasset; pero tan solo recientemente han sido traducidos al inglés por Guy Oakes. Un concepto central en Simmel es la equiparación de lo "objetivo" con lo "masculino" y lo "subjetivo" con lo "femenino." Se repasan las distintas reacciones provocadas por las ideas de Simmel en diversas épocas y en las diversas comunidades del lenguaje - como las ediciones mencionadas-, incluyendo las de Karen Horney, José Ortega y Gasset, Rosa Chacel, y Julian Marías. A pesar de la publicación temprana en el mundo de habla hispana, existía una carencia de verdadero interés por la emancipación de la mujer entre esos conocedores de las ideas de Simmel, excepto Rosa Chacel.

11C-MET PET/MRI for detection of recurrent glioma.

Science.gov (United States)

Deuschl, C; Kirchner, J; Poeppel, T D; Schaarschmidt, B; Kebir, S; El Hindy, N; Hense, J; Quick, H H; Glas, M; Herrmann, K; Umutlu, L; Moenninghoff, C; Radbruch, A; Forsting, M; Schlamann, M

2018-04-01

Radiological assessment of brain tumors is widely based on the Radiology Assessment of Neuro-Oncology (RANO) criteria that consider non-specific T1 and T2 weighted images. Limitation of the RANO criteria is that they do not include metabolic imaging techniques that have been reported to be helpful to differentiate treatment related changes from true tumor progression. In the current study, we assessed if the combined use of MRI and PET with hybrid 11 C-MET PET/MRI can improve diagnostic accuracy and diagnostic confidence of the readers to differentiate treatment related changes from true progression in recurrent glioma. Fifty consecutive patients with histopathologically proven glioma were prospectively enrolled for a hybrid 11 C-MET PET/MRI to differentiate recurrent glioma from treatment induced changes. Sole MRI data were analyzed based on RANO. Sole PET data and in a third evaluation hybrid 11 C-MET-PET/MRI data were assessed for metabolic respectively metabolic and morphologic glioma recurrence. Diagnostic performance and diagnostic confidence of the reader were calculated for the different modalities, and the McNemar test and Mann-Whitney U Test were applied for statistical analysis. Hybrid 11 C-MET PET/MRI was successfully performed in all 50 patients. Glioma recurrence was diagnosed in 35 of the 50 patients (70%). Sensitivity and specificity were calculated for MRI (86.11% and 71.43%), for 11 C-MET PET (96.77% and 73.68%), and for hybrid 11 C-MET-PET/MRI (97.14% and 93.33%). For diagnostic accuracy hybrid 11 C-MET-PET/MRI (96%) showed significantly higher values than MRI alone (82%), whereas no significant difference was found for 11C-MET PET (88%). Furthermore, by rating on a five-point Likert scale significantly higher scores were found for diagnostic confidence when comparing 11 C-MET PET/MRI (4.26 ± 0,777) to either PET alone (3.44 ± 0.705) or MRI alone (3.56 ± 0.733). This feasibility study showed that hybrid PET/MRI might strengthen

Medio ambiente, calidad de vida y consumismo. Esclavos de lo superfluo

Directory of Open Access Journals (Sweden)

Víctor M. Mora Padrón

2001-06-01

Full Text Available Nuestras vidas se encuentran programadas totalmente por costumbres, estilos de vida, intereses económicos y modas. Es evidente que siempre han existido intereses, hábitos y modas, pero nunca como ahora éstos habían sido manipulados a gran escala. Potenciando unos y otros el consumo masivo. Ante tamaño alud de productos que nos aturden, lo esencial se ha perdido entre lo secundario. Por este motivo las necesidades reales de la sociedad, hoy, son cada vez más difíciles de definir.

LO-phonon and plasmon coupling in neutron-transmutation-doped GaAs

International Nuclear Information System (INIS)

Kuriyama, K.; Sakai, K.; Okada, M.

1996-01-01

Coupling between the longitudinal-optic (LO) phonon mode and the longitudinal plasma mode in neutron-transmutation-doped (NTD) semi-insulating GaAs was studied using Raman-scattering spectroscopy and a Fourier-transform infrared spectrometer. When the electron concentration due to the activation of NTD impurities (Ge Ga and Se As ) approaches ∼8x10 16 cm -3 , the LO-phonon endash plasmon coupling is observed. This behavior is consistent with the free-electron absorption due to the activation of NTD impurities in samples annealed above 600 degree C. copyright 1996 The American Physical Society

Improving high resolution retinal image quality using speckle illumination HiLo imaging.

Science.gov (United States)

Zhou, Xiaolin; Bedggood, Phillip; Metha, Andrew

2014-08-01

Retinal image quality from flood illumination adaptive optics (AO) ophthalmoscopes is adversely affected by out-of-focus light scatter due to the lack of confocality. This effect is more pronounced in small eyes, such as that of rodents, because the requisite high optical power confers a large dioptric thickness to the retina. A recently-developed structured illumination microscopy (SIM) technique called HiLo imaging has been shown to reduce the effect of out-of-focus light scatter in flood illumination microscopes and produce pseudo-confocal images with significantly improved image quality. In this work, we adopted the HiLo technique to a flood AO ophthalmoscope and performed AO imaging in both (physical) model and live rat eyes. The improvement in image quality from HiLo imaging is shown both qualitatively and quantitatively by using spatial spectral analysis.

Invloed krachtvoerniveau op vleesproduktiekenmerken van Piemontese met zwartbont kruislingstieren

NARCIS (Netherlands)

Hanekamp, W.J.A.

1989-01-01

Met 3 ronden van elk 36 Piemontese X zwartbonte kruislingstieren is het effect van extra krachtvoer vergeleken met de normaal gangbare gift naast onbeperkt snijmaoskuil. De stieren waren gehuisvest in een natuurlijk geventileerde stal (space-boarding)en op een volledige roostervloer.

Los punzones metálicos en los contextos funerarios argáricos: los casos de Fuente Álamo (Cuevas de Almazora, Almería) y la Cuesta del Negro (Purullena, Granada)

OpenAIRE

Sandra Pérez Ibáñez

2011-01-01

La Cultura de El Argar marca el comienzo de la Edad del Bronce en el Sudeste peninsular caracterizada por enterramientos en las áreas de habitación, bajo el suelo de las casas habitualmente. Siempre inhumaciones en posición flexionada, contienen por lo general solo un individuo que puede acompañarse en ocasiones de ajuar. Es dentro del análisis de éste último donde, en el presente artículo, se realiza una aproximación a la variedad de los punzones metálicos a partir del análisis morfométrico ...

Pastoors naar de PFA: nieuwe impuls voor samenwerking met de wetenschap (interview met Martin Pastoors)

NARCIS (Netherlands)

Pastoors, M.A.

2014-01-01

De Pelagic Freezer-trawler Association (PFA) heeft visserijonderzoeler Martin Pastoors aangenomen als 'Chief Science Officer'. De afgelopen tien jaar is de PFA zich steeds meer bezig gaan houden met wetenschappelijk onderzoek. Bijvoorbeeld door het ontwikkelen van nieuwe manieren om data te

Met Ed gets reprieve: banks lend tax money

International Nuclear Information System (INIS)

Utroska, D.

1981-01-01

A consortium of banks agreed to loan Metropolitan Edison $23 million to pay its April 15 state taxes and temporarily relieve a cash-flow problem that is leading to default after the Pennsylvania Public Utility Commission expedited a rate request. The continued solvency of Met Ed is a matter of speculation because the present credit formula is based on liquid assets which the PUC did not address. While the action taken by the bankers gives Met Ed a reprieve, it does not provide a long-term solution. The Revolving Credit Agreement will expire on October 1. Met Ed is still faced with the problem of relicensing Three Mile Island-1 unit and the cost of underwriting the cleanup of the No. 2 unit

Negociar lo que vas a negociar: el proceso de negociación

OpenAIRE

Soleto Muñoz, Helena

2010-01-01

Uno de los momentos clave del proceso de negociación es el de programación, pues, dado que las partes suelen tener distintas formas de contemplar la negociación, es positivo que se dediquen a "negociar lo que se va a negociar", aclarando en lo posible la forma de las reuniones, la extensión de la negociación y las reglas básicas en la negociación.

Recent advances in the discovery of small molecule c-Met Kinase inhibitors.

Science.gov (United States)

Parikh, Palak K; Ghate, Manjunath D

2018-01-01

c-Met is a prototype member of a subfamily of heterodimeric receptor tyrosine kinases (RTKs) and is the receptor for hepatocyte growth factor (HGF). Binding of HGF to its receptor c-Met, initiates a wide range of cellular signalling, including those involved in proliferation, motility, migration and invasion. Importantly, dysregulated HGF/c-Met signalling is a driving factor for numerous malignancies and promotes tumour growth, invasion, dissemination and/or angiogenesis. Dysregulated HGF/c-Met signalling has also been associated with poor clinical outcomes and resistance acquisition to some approved targeted therapies. Thus, c-Met kinase has emerged as a promising target for cancer drug development. Different therapeutic approaches targeting the HGF/c-Met signalling pathway are under development for targeted cancer therapy, among which small molecule inhibitors of c-Met kinase constitute the largest effort within the pharmaceutical industry. The review is an effort to summarize recent advancements in medicinal chemistry development of small molecule c-Met kinase inhibitors as potential anti-cancer agents which would certainly help future researchers to bring further developments in the discovery of small molecule c-Met kinase inhibitors. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors.

Science.gov (United States)

Xu, Jimin; Ai, Jing; Liu, Sheng; Peng, Xia; Yu, Linqian; Geng, Meiyu; Nan, Fajun

2014-06-14

A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3'-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells.

Aproximaciones a una estética de lo americano

Directory of Open Access Journals (Sweden)

María del Milagro Casalla

2010-01-01

Full Text Available El legado filosófico que nos ha dejado Rodolfo Kusch tiene cada vez más presencia y valor en este largo itinerario de descubrirnos como americanos. La pasión de este pensador por la América profunda es una fuente de ins- piración para quienes creemos que vivir en América no es simplemente un episodio geográfico sino un horizonte desde y a partir del cual construimos nuestra identidad. En este trabajo se pretende recrear sus consideracio - nes estéticas recogidas en su ensayo “Anotaciones para una estética de lo americano”, escrito en el año 1955. Aunque se trata de uno de los primeros escritos de Rodolfo Kusch, en el mismo se encuentran presentes numerosos conceptos que luego serán tematizados extensamente a lo largo de toda su obra. Considero que el abordaje a sus consideraciones estéticas no ha sido tan frecuentado como sí otros aspectos de su pensamiento (ser-estar, geocultura, símbolo y religión, etc.. Por ello, creo que este trabajo puede constituir una orientación preeliminar para futuras interpretaciones y, a la vez, ser un humilde homenaje a su filosofía, que, a lo largo de los años, sigue estimulando a antiguas y nuevas generaciones de pensadores dedicados a la filosofía latinoamericana.

Alessandro Volta, l'uomo e lo scienziato

OpenAIRE

Bevilacqua, F.; Falomo, L.; Montalbetti, Claudia

1999-01-01

Per il secondo centenario dell'invenzione della pila elettrica da parte di Alessandro Volta continuano a nascere interessanti iniziative. L'ultima in ordine di tempo, ma non certo per importanza, è stata la progettazione e la realizzazione del sito Alessandro Volta, l'uomo e lo scienziato, che ha visto collaborare attivamente il Laboratorio di Tecnologie Educative Multimediali (Università di Pavia - Dipartimento di Fisica "A. Volta") e il CILEA

La falta de Laclau: lo imaginario

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Julio Aibar

2014-06-01

Full Text Available En la obra de Laclau hay una clara deficiencia: la del registro de lo Imaginario. La no inclusión de ese registro en el andamiaje conceptual que sostiene a la teoría de la hegemonía, hace que la misma sea endeble en sus principales desarrollos. En este artículo doy cuenta, a la luz de la obra de Lacan, del silencio teórico de Laclau, para después explorar las consecuencias de dicho silencio para el análisis político.

Del viaje o de lo órfico en la literatura

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Carlos Guevara A.

1997-04-01

Full Text Available Una de las características del mito es el reconocimiento de una carencia en el tiempo presente. El mito de Orfeo con su descenso al Hades, puede simbolizar, y de hecho simboliza, la inclinación humana que por el sendero de la iniciación logra el descubrimiento del ser interior, del sí mismo junguiano, en donde reside la verdad de cada hombre. En la literatura universal (antigua y contemporánea el viaje del protagonista representa ese descenso al Hades por parte de los individuos que, queriendo trascender lo material, se hallan frente a la luz interior que suplirá las carencias de la vida prosaica en la que discurre lo mundano.

Del viaje o de lo órfico en la literatura

Directory of Open Access Journals (Sweden)

Carlos Guevara A.

1997-01-01

Full Text Available Una de las características del mito es el reconocimiento de una carencia en el tiempo presente. El mito de Orfeo con su descenso al Hades, puede simbolizar, y de hecho simboliza, la inclinación humana que por el sendero de la iniciación logra el descubrimiento del ser interior, del sí mismo junguiano, en donde reside la verdad de cada hombre. En la literatura universal (antigua y contemporánea el viaje del protagonista representa ese descenso al Hades por parte de los individuos que, queriendo trascender lo material, se hallan frente a la luz interior que suplirá las carencias de la vida prosaica en la que discurre lo mundano.

LO2/LH2 propulsion for outer planet orbiter spacecraft

Science.gov (United States)

Garrison, P. W.; Sigurdson, K. B.

1983-01-01

Galileo class orbiter missions (750-1500 kg) to the outer planets require a large postinjection delta-V for improved propulsion performance. The present investigation shows that a pump-fed low thrust LO2/LH2 propulsion system can provide a significantly larger net on-orbit mass for a given delta-V than a state-of-the-art earth storable, N2O4/monomethylhydrazine pressure-fed propulsion system. A description is given of a conceptual design for a LO2/LH2 pump-fed propulsion system developed for a Galileo class mission to the outer planets. Attention is given to spacecraft configuration, details regarding the propulsion system, the thermal control of the cryogenic propellants, and aspects of mission performance.

Metáfora y estructura conceptual

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Emilia Castaño

2012-01-01

Full Text Available La lingüística cognitiva siempre ha argumentado que la metáfora no pertenece exclusivamente al lenguaje, sino que es una competencia que se basa en la habilidad humana de concebir un dominio de experiencia en términos de otro. Entendida así, la metáfora no puede ser otra cosa que un fenómeno conceptual. No obstante, pocos adeptos de la lingüística cognitiva han concentrados sus esfuerzos en catalogar manifestaciones metafóricas en ámbitos no lingüísticos. En este trabajo, sugerimos que es factible encontrar pruebas de que la metáfora es un proceso conceptual y, como tal, se manifiesta en esferas que no son estrictamente lingüísticas. Para ello, aportamos un seguido de evidencias muy diversas, como por ejemplo su papel en el razonamiento lógico-matemático de los niños en la fase preoperacional del desarrollo cognitivo, la programación de interfaces para aplicaciones informáticas y los resultados de tres estudios empíricos realizados recientemente en el campo  de la psicología cognitiva que analizan los efectos whorfianos en la conceptualización del tiempo y los efectos del espacio en la memoria emocional.

En los bordes de lo jurídico: campesinos y justicia en Santiago del Estero

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Pablo Barbetta

2010-12-01

Full Text Available El objetivo de este trabajo se centrará en la forma en que el conflicto por la tenencia legal de la tierra llevado a cabo por las comunidades campesinas se expresa en el ámbito judicial. Priorizamos dicho ámbito por sobre otros ya que, en la tradición democrática, en él se determina lo que es justo y lo injusto, esto es, se establece la medida misma según la cual cada parte sólo toma lo que le corresponde (Rancière, 1996. En este contexto, me interesan particularmente dos cuestiones. La primera, abordar la forma en que los distintos sujetos intervinientes representan los acontecimientos de un modo judiciable. La segunda cuestión remite a analizar cómo los jueces se trasladan de estos lenguajes de la imaginación a otro, que supone la toma de una decisión. Es decir, se trata de analizar y comprender el papel de los jueces en lo relativo a la resolución de los conflictos entre campesinos y empresarios.

Le tourisme religieux à La Havane et l’accusation de mercantilisme

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Kali Argyriadis

2007-07-01

researches conducted in Havana, this article also addresses the classical distinction between sacred and profane. Distinctions between cultural, artistic, religious, political, emotional and economical dimensions will also be discussed. We will see that those dimensions are always manifest and connected together in touristic shows as well as in religious ceremonies.El turismo cultural, que se nutre abundantemente del tema afrocubano, se ha desarrollado considerablemente en Cuba en esta última decada. Paralelamente, un número creciente de visitantes extranjeros viajan a la isla con el propósito de adentrarse al mundo de las llamadas religiones de origen africano (santería y palo-monte. En el dificil contexto económico actual, la religión se ha convertido hoy en día en uno de los medios lucrativos más seguros para mejorar la situación material de muchos cubanos, lo que genera toda una serie de críticas en varios niveles de la sociedad. Este artículo pretende reflexionar sobre este fenómeno, tratando de analizar la crítica del mercantilismo como una categoría de acusación ambigua inherente a los intercambios entre religiosos, así como a las relaciones sociales en general. A partir de datos etnográficos habaneros, se cuestionará también la distinción clásica entre lo profano y lo sagrado, así como entre lo cultural, lo artístico, lo religioso, lo político, lo afectivo y lo económico, puesto que todas estas dimensiones estan intrinsecamente ligadas tanto en un espectáculo turístico como en una ceremonia religiosa.

Activated HGF-c-Met Axis in Head and Neck Cancer

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Levi Arnold

2017-12-01

Full Text Available Head and neck squamous cell carcinoma (HNSCC is a highly morbid disease. Recent developments including Food and Drug Administration (FDA approved molecular targeted agent’s pembrolizumab and cetuximab show promise but did not improve the five-year survival which is currently less than 40%. The hepatocyte growth factor receptor; also known as mesenchymal–epithelial transition factor (c-Met and its ligand hepatocyte growth factor (HGF are overexpressed in head and neck squamous cell carcinoma (HNSCC; and regulates tumor progression and response to therapy. The c-Met pathway has been shown to regulate many cellular processes such as cell proliferation, invasion, and angiogenesis. The c-Met pathway is involved in cross-talk, activation, and perpetuation of other signaling pathways, curbing the cogency of a blockade molecule on a single pathway. The receptor and its ligand act on several downstream effectors including phospholipase C gamma (PLCγ, cellular Src kinase (c-Src, phosphotidylinsitol-3-OH kinase (PI3K alpha serine/threonine-protein kinase (Akt, mitogen activate protein kinase (MAPK, and wingless-related integration site (Wnt pathways. They are also known to cross-talk with other receptors; namely epidermal growth factor receptor (EGFR and vascular endothelial growth factor receptor (VEGFR and specifically contribute to treatment resistance. Clinical trials targeting the c-Met axis in HNSCC have been undertaken because of significant preclinical work demonstrating a relationship between HGF/c-Met signaling and cancer cell survival. Here we focus on HGF/c-Met impact on cellular signaling in HNSCC to potentiate tumor growth and disrupt therapeutic efficacy. Herein we summarize the current understanding of HGF/c-Met signaling and its effects on HNSCC. The intertwining of c-Met signaling with other signaling pathways provides opportunities for more robust and specific therapies, leading to better clinical outcomes.

La posteridad sociológica de Auguste Comte: Lo normal y lo patológico en Durkheim

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MICHEL BOURDEAU

2008-01-01

Full Text Available Este artículo completa un texto que, bajo el título «Ciencia, religión y sociedad en Auguste Comte», fue publicado en el año 2003 en las páginas de esta revista. Después de un breve repaso de los conceptos sociológicos fundamentales del Cours de philosophie positive, se muestra como el pensamiento de Durkheim se constituyó a través de una discusión crítica con el positivismo. Concretamente, se examinan dos momentos fundamentales de dicha confrontación. En primer lugar, se analiza como la distinción que Durkheim establece en La división du travail social (1893 entre solidaridad mecánica y solidaridad orgánica tenía como objetivo fundamental demostrar que Comte se había equivocado al extraer ciertas consecuencias sobre el progreso de la división del trabajo. En segundo lugar, se muestra como en Les Règles de la méthode sociologique (1895, Durkheim atribuye a Comte la distinción entre lo normal y lo patológico y reinterpreta dicha distinción a partir del concepto de «media» de Quételet. En este contexto, concluimos señalando que Durkheim debe a Comte la idea de que la sociología permite construir una ciencia de la moral.

Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy.

Science.gov (United States)

Lauterbach, Marcel A; Ronzitti, Emiliano; Sternberg, Jenna R; Wyart, Claire; Emiliani, Valentina

2015-01-01

Imaging intracellular calcium concentration via reporters that change their fluorescence properties upon binding of calcium, referred to as calcium imaging, has revolutionized our way to probe neuronal activity non-invasively. To reach neurons densely located deep in the tissue, optical sectioning at high rate of acquisition is necessary but difficult to achieve in a cost effective manner. Here we implement an accessible solution relying on HiLo microscopy to provide robust optical sectioning with a high frame rate in vivo. We show that large calcium signals can be recorded from dense neuronal populations at high acquisition rates. We quantify the optical sectioning capabilities and demonstrate the benefits of HiLo microscopy compared to wide-field microscopy for calcium imaging and 3D reconstruction. We apply HiLo microscopy to functional calcium imaging at 100 frames per second deep in biological tissues. This approach enables us to discriminate neuronal activity of motor neurons from different depths in the spinal cord of zebrafish embryos. We observe distinct time courses of calcium signals in somata and axons. We show that our method enables to remove large fluctuations of the background fluorescence. All together our setup can be implemented to provide efficient optical sectioning in vivo at low cost on a wide range of existing microscopes.

Anti-c-MET Nanobody - a new potential drug in multiple myeloma treatment.

Science.gov (United States)

Slørdahl, Tobias Schmidt; Denayer, Tinneke; Moen, Siv Helen; Standal, Therese; Børset, Magne; Ververken, Cedric; Rø, Torstein Baade

2013-11-01

c-MET is the tyrosine kinase receptor of the hepatocyte growth factor (HGF). HGF-c-MET signaling is involved in many human malignancies, including multiple myeloma (MM). Recently, multiple agents have been developed directed to interfere at different levels in HGF-c-MET signaling pathway. Nanobodies are therapeutic proteins based on the smallest functional fragments of heavy-chain-only antibodies. In this study, we wanted to determine the anticancer effect of a novel anti-c-MET Nanobody in MM. We examined the effects of an anti-c-MET Nanobody on thymidine incorporation, migration, adhesion of MM cells, and osteoblastogenesis in vitro. Furthermore, we investigated the effects of the Nanobody on HGF-dependent c-MET signaling by Western blotting. We show that the anti-c-MET Nanobody effectively inhibited thymidine incorporation of ANBL-6 MM cells via inhibition of an HGF autocrine growth loop and thymidine incorporation in INA-6 MM cells induced by exogenous HGF. HGF-induced migration and adhesion of INA-6 were completely and specifically blocked by the Nanobody. Furthermore, the Nanobody abolished the inhibiting effect of HGF on bone morphogenetic protein-2-induced alkaline phosphatase activity and the mineralization of human mesenchymal stem cells. Finally, we show that the Nanobody reduced phosphorylation of tyrosine residues in c-MET, MAPK, and Akt. We also compared the Nanobody with anti-c-MET monoclonal antibodies and revealed the similar or better effect. The anti-c-MET Nanobody inhibited MM cell migration, thymidine incorporation, and adhesion, and blocked the HGF-mediated inhibition of osteoblastogenesis. The anti-c-MET Nanobody might represent a novel therapeutic agent in the treatment of MM and other cancers driven by HGF-c-MET signaling. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Lo Gnomone Clementino Astronomia Meridiana in Basilica

Science.gov (United States)

Sigismondi, Costantino

2014-05-01

Costruito per chiara volontà del papa 70 anni dopo il caso Galileo, lo Gnomone Clementino è un grande telescopio solare che non fa uso di lenti a 92 anni dall’invenzione del cannocchiale. Queste due caratteristiche basterebbero da sole a giustificare l’interesse verso questo strumento. L’astronomia meridiana è alla base dell’astrometria e dell’astrofisica moderna. Lo Gnomone Clementino sta oggi all’astronomia, come il veliero “Amerigo Vespucci” sta alla Marina Italiana. E’ possibile svolgere ogni genere di osservazione e studio su questo strumento, e dal 2002 vi tengo lezioni teorico-pratiche del corso di Storia dell’Astronomia e La Terra nel Sistema Solare della Sapienza, Università di Roma, Facoltà di Lettere e Filosofia. Questo testo aggiunge alcuni tasselli alla ricerca storica sulla meridiana, appoggiandosi, com’è naturale, sulle spalle di giganti che mi hanno preceduto in questi studi. In particolare la misura dell’azimut della meridiana, ed il suo inquadramento tra gli strumenti simili ed alcuni studi di astrometria sui dati del 1701-1703 di Bianchini, che sono apparsi fin’ora soltanto su riviste specializzate ed in Inglese vengono qui proposti in Italiano e semplificati, per valorizzare sempre più questa straordinaria opera d’arte e di scienza.

Raul Meel ja Ülo Sooster ajakirjas Zimmerli Journal

Index Scriptorium Estoniae

2007-01-01

Ajakirjas Zimmerli Journal, Fall, 2006, lk. 88-103 Jeremy Canwelli artikkel "System, Terminus and Time : The Mystical Art of Raul Meel" ja lk. 118-125 Leonid Lammi mälestused "Ülo Sooster : an Artist, a Friend and his Time"

Las miradas poéticas de Narciso y Medusa: la transformacion de lo real

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Sergio Blanco

2015-04-01

Full Text Available Al ser director tanto académico como artístico de este proyecto europeo Crossing Stages, esta doble condición me lleva a tomar la palabra desde estos dos lugares, es decir, desde lo académico y desde lo artístico. Desde dos lugares entonces casi antagónicos. La toma de la palabra académica responde en cierta forma a ciertas máximas de claridad y precisión, suele tender a ser un discurso mesurado, ordenado y equilibrado, que en cierta forma busca un conocimiento erudito por medio de procedimientos científicos lo más objetivos y sólidos posibles. Mientras que la toma de la palabra artística es todo lo contrario, es una palabra oscura, confusa, hiperbólica, amanerada, completamente desmesurada y caótica, y basada en experiencias y caprichos inminentemente subjetivos. Se me plantea entonces desde qué lugar hablar:  

Araucanía (Chile) y su territorio: un contraste entre lo etéreo y lo material

OpenAIRE

Rodríguez Domínguez, Cristian Pablo; Saavedra Teigue, Andrea Alejandra

2010-01-01

La Araucanía, ubicada al sur de Chile, es uno de los territorios que posee mayor diversidad cultural como fruto del proceso de colonización que otorgó un sello distintivo a esta zona a fines del siglo XIX, lo que se puede apreciar en diferentes manifestaciones, muchas de las cuales encuentran su máxima expresión a través de la arquitectura, la que materializa una compleja realidad cargada de ritos, emocionalidad y tradiciones tanto europeas, chilenas o mapuche que conviven fundiéndose en un p...

Relato policial y el crimen que lo habita

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Francisco de Undurraga

2011-05-01

Full Text Available La aparición de publicidad y de novelas en serie en las portadas de periódicos franceses, apartir de 1836, marca la relación entre el género policial y los nuevos modos de visibilidad de la información en las sociedades industrializadas. Algunos ejemplos, tomados de un periódico de la época, la "Gazette des Tribunaux", permiten demostrar que la prensa estuvo desde sus comienzos vinculada a la literatura, si acaso no es una derivación de ella. E.A. Poe, creador del relato policial, conduce la retórica del morbo trabajada por Dante, Swift, Lautréamont y Baudelaire, de una apelación al lector, al orden del argumento y del procedimiento que lo estructura. En el relato policial conviven el discurso de lo que se cuenta, característico de la literatura, y el de la ciencia, pero solo en apariencia éste viene a suplantar a aquél, configurando de este modo su retórica.

Mogelijkheden om vroeg tijdig bladrandproblemen te signaleren met MIPS bij Hortensia

NARCIS (Netherlands)

Noort, van F.R.; Jalink, H.

2010-01-01

Met geavanceerde camera technieken zijn beelden vast te leggen van fotosynthese activiteit en het is ook mogelijk gebleken om bladgedeelten met stress vast te leggen, zonder dat deze stress met het blote oog al te zien is. Dit opent perspectieven om monitorringonderzoek te doen naar het ontstaan van

Design and Implementation of Image Research for the Columbia Mets

Science.gov (United States)

1992-01-01

the other hand, developed an unusual camaraderie through identifying with their underdog Mets." (7) Teams are finding good public relations programs do...supports the club. Question 24 was designed to measure brand loyalty by respondents to Mets sponsors versus non-Mets sponsors. Finally, question 27...be done to attract crowds. Especially with a brand new stadium. The Carolinas, in my opinion, are big minor league baseball states. Let’s get people

Alternative Fuels Data Center: Workplace Charging Success: MetLife

Science.gov (United States)

future." Several others noted that their decision to purchase or lease a PEV was based on MetLife's : MetLife " By making PEV charging stations more readily available to employees, we can encourage more promote alternative transportation. By making PEV charging stations more readily available to employees

Aerial radiological survey of the Palo Verde Nuclear Generating Station and surrounding area, Wintersburg, Arizona. Date of survey: November 1982

International Nuclear Information System (INIS)

Semmler, R.A.

1984-01-01

An aerial survey of terrestrial gamma radiation was performed during the period 4 November through 15 November 1982 over a 16-kilometer by 16-kilometer (10-mile by 10-mile) area approximately centered on the Palo Verde Nuclear Generating Station near Wintersburg, Arizona. Gamma radiation spectral data were collected while flying a helicopter over a regular pattern of parallel lines spaced 150 meters (500 feet) apart at an altitude of 90 meters (300 feet). All radiation measurements taken at the nominal flight altitude were corrected for altitude variations, cosmic radiation, and helicopter background to generate exposure rates from terrestrial sources extrapolated to 1 meter above ground level. The data are presented as isoradiation contour maps. The average terrestrial radiation levels fall between 8 and 14 microrentgens per hour (μR/h). All gamma radiation detected within the survey area was associated with naturally occurring radionuclides. Direct ground-based measurements at 1 meter height were also taken at four scattered sites within the survey area. These values agree with the contour intervals determined from the aerial measurements and differ from the mean value of adjacent contours by no more than 10%. 6 references, 5 figures, 2 tables

Vingerpussid Juku ja Juhani palgaga / Ülo Ennuste

Index Scriptorium Estoniae

Ennuste, Ülo, 1932-

2004-01-01

Majandusprofessor Ülo Ennuste võrdleb 5000 ja 50 000 kroonise palga 5-10%-list tõusu ja järeldab, et ebavõrdsete majanduste puhul ei saa iga lõppeva aasta kohta teha mõistlike majanduslikku edukuse võrdlusi kasvutempode ja valemite alusel. Autor rõhutab, et tõepärane tulevikuarvutus peab olema tõenäosuslik

Cetuximab-Induced MET Activation Acts as a Novel Resistance Mechanism in Colon Cancer Cells

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Na Song

2014-04-01

Full Text Available Aberrant MET expression and hepatocyte growth factor (HGF signaling are implicated in promoting resistance to targeted agents; however, the induced MET activation by epidermal growth factor receptor (EGFR inhibitors mediating resistance to targeted therapy remains elusive. In this study, we identified that cetuximab-induced MET activation contributed to cetuximab resistance in Caco-2 colon cancer cells. MET inhibition or knockdown sensitized Caco-2 cells to cetuximab-mediated growth inhibition. Additionally, SRC activation promoted cetuximab resistance by interacting with MET. Pretreatment with SRC inhibitors abolished cetuximab-mediated MET activation and rendered Caco-2 cells sensitive to cetuximab. Notably, cetuximab induced MET/SRC/EGFR complex formation. MET inhibitor or SRC inhibitor suppressed phosphorylation of MET and SRC in the complex, and MET inhibitor singly led to disruption of complex formation. These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer.

MetWAMer: eukaryotic translation initiation site prediction

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Brendel Volker

2008-09-01

Full Text Available Abstract Background Translation initiation site (TIS identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences from transcript data. We have developed the MetWAMer package for TIS prediction in eukaryotic open reading frames of non-viral origin. MetWAMer can be used as a stand-alone, third-party tool for post-processing gene structure annotations generated by external computational programs and/or pipelines, or directly integrated into gene structure prediction software implementations. Results MetWAMer currently implements five distinct methods for TIS prediction, the most accurate of which is a routine that combines weighted, signal-based translation initiation site scores and the contrast in coding potential of sequences flanking TISs using a perceptron. Also, our program implements clustering capabilities through use of the k-medoids algorithm, thereby enabling cluster-specific TIS parameter utilization. In practice, our static weight array matrix-based indexing method for parameter set lookup can be used with good results in data sets exhibiting moderate levels of 5'-complete coverage. Conclusion We demonstrate that improvements in statistically-based models for TIS prediction can be achieved by taking the class of each potential start-methionine into account pending certain testing conditions, and that our perceptron-based model is suitable for the TIS identification task. MetWAMer represents a well-documented, extensible, and freely available software system that can be readily re-trained for differing target applications and/or extended with existing and novel TIS prediction methods, to support further research efforts in this area.

Sedimentation survey of Lago Loíza, Trujillo Alto, Puerto Rico, July 2009

Science.gov (United States)

Soler-López, Luis R.; Licha-Soler, N.A.

2014-01-01

Lago Loíza is a reservoir formed at the confluence of Río Gurabo and Río Grande de Loíza in the municipality of Trujillo Alto in central Puerto Rico, about 10 kilometers (km) north of the town of Caguas, about 9 km northwest of Gurabo, and about 3 km south of Trujillo Alto (fig. 1). The Carraizo Dam is owned and operated by the Puerto Rico Aqueduct and Sewer Authority (PRASA), and was constructed in 1953 as a water-supply reservoir for the San Juan Metropolitan area. The dam is a concrete gravity structure that is located in a shallow valley and has a gently sloping left abutment and steep right abutment. Non-overflow sections flank the spillway section. Waterways include an intake structure for the pumping station and power plant, sluiceways, a trash sluice, and a spillway. The reservoir was built to provide a storage capacity of 26.8 million cubic meters (Mm3) of water at the maximum pool elevation of 41.14 meters (m) above mean sea level (msl) for the Sergio Cuevas Filtration Plant that serves the San Juan metropolitan area. The reservoir has a drainage area of 538 square kilometers (km2) and receives an annual mean rainfall that ranges from 1,600 to 5,000 millimeters per year (mm/yr). The principal streams that drain into Lago Loíza are the Río Grande de Loíza, Río Gurabo, and Río Cañas. Two other rivers, the Río Bairoa and Río Cagüitas, discharge into the Río Grande de Loíza just before it enters the reservoir. The combined mean annual runoff of the Río Grande de Loíza and the Río Gurabo for the 1960–2009 period of record is 323 Mm3. Flow from these streams constitutes about 89 percent of the total mean annual inflow of 364 Mm3 to the reservoir (U.S. Geological Survey, 2009). Detailed information about Lago Loíza reservoir structures, historical sediment accumulation, and a dredge conducted in 1999 are available in Soler-López and Gómez-Gómez (2005). During July 8–15, 2009, the U.S. Geological Survey (USGS) Caribbean Water Science

Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Dockets Nos. STN 50-528, STN 50-529, and STN 50-530)

International Nuclear Information System (INIS)

1987-03-01

Supplement No. 11 to the Safety Evaluation Report for the application filed by Arizona Public Service Company et al. for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizone, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of (1) additional information submitted by the applicant since Supplement No. 10 was issued and (2) other matters requiring staff review since Supplenent No. 10 was issued, specifically those issues that required resolution before Unit 3 low-power licensing

c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.

Science.gov (United States)

Granito, Alessandro; Guidetti, Elena; Gramantieri, Laura

2015-01-01

c-MET is the membrane receptor for hepatocyte growth factor (HGF), also known as scatter factor or tumor cytotoxic factor, a mitogenic growth factor for hepatocytes. HGF is mainly produced by cells of mesenchymal origin and it mainly acts on neighboring epidermal and endothelial cells, regulating epithelial growth and morphogenesis. HGF/MET signaling has been identified among the drivers of tumorigenesis in human cancers. As such, c-MET is a recognized druggable target, and against it, targeted agents are currently under clinical investigation. c-MET overexpression is a common event in a wide range of human malignancies, including gastric, lung, breast, ovary, colon, kidney, thyroid, and liver carcinomas. Despite c-MET overexpression being reported by a large majority of studies, no evidence for a c-MET oncogenic addiction exists in hepatocellular carcinoma (HCC). In particular, c-MET amplification is a rare event, accounting for 4%-5% of cases while no mutation has been identified in c-MET oncogene in HCC. Thus, the selection of patient subgroups more likely to benefit from c-MET inhibition is challenging. Notwithstanding, c-MET overexpression was reported to be associated with increased metastatic potential and poor prognosis in patients with HCC, providing a rationale for its therapeutic inhibition. Here we summarize the role of activated HGF/MET signaling in HCC, its prognostic relevance, and the implications for therapeutic approaches in HCC.

Lo global y lo local en la tecnología del deporte

Directory of Open Access Journals (Sweden)

KLAUS HEINEMANN

2009-09-01

Full Text Available En el presente artículo se analizan los efectos de la globalización y el influjo de las culturas locales sobre el desarrollo y el uso de las tecnologías del deporte –como por ejemplo, de barcos de vela, bicicletas, esquíes, etc.– y sobre la expansión de los mercados de comercialización de artículos deportivos. Se señala que sólo cuando exista una profunda diferenciación de una tecnología del deporte concreta podrá hacerse visible la diversidad de los efectos globales y locales. Contra la tesis de una estandarización mundial de bienes y servicios uniformes y, por tanto, de una nivelación de la práctica deportiva, se encuentra el hecho de que con el desarrollo tecnológico se incrementan enormemente los “grados de libertad”, que abren un espacio casi inagotable a la individualización y a la capacidad de adaptación a las culturas locales.

Prognostic impact of tumor MET expression among patients with stage IV gastric cancer

DEFF Research Database (Denmark)

Erichsen, Rune; Kelsh, Michael A; Oliner, Kelly S

2016-01-01

PURPOSE: We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse. METHODS: The study included archived cancer specimens from 103...... stage IV gastric cancer patients (2003-2010). We analyzed MET-protein expression by immunohistochemistry (MET-positive if ≥25% of tumor cells showed MET expression). We calculated overall survival using the Kaplan-Meier method and hazard ratios comparing mortality among MET-positive and MET.......6 months), corresponding to an adjusted hazard ratio of 2.2 (95% confidence interval, 1.3-3.7). CONCLUSIONS: Tumor MET expression is prevalent and has substantial prognostic impact in stage IV gastric cancer patients....

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin

DEFF Research Database (Denmark)

Keusekotten, K.; Elliott, P.R.; Kulathu, Y.

2013-01-01

The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor κB (NF-κB) signaling. Deubiquitinases (DUBs) are key regulators of Ub signaling, but a dedicated DUB for Met1 linkages has...... not been identified. Here, we reveal a previously unannotated human DUB, OTULIN (also known as FAM105B), which is exquisitely specific for Met1 linkages. Crystal structures of the OTULIN catalytic domain in complex with diubiquitin reveal Met1-specific Ub-binding sites and a mechanism of substrate...

Report of the panel on evaluation of ground-water flow in fractures at the Palo Duro Basin, Texas: Unanalyzed data: Technical report

International Nuclear Information System (INIS)

1988-01-01

A peer review group of hydrologists assessed the importance and availability of data on fracture-controlled ground-water flow at the Palo Duro Basin sites in the Permian Basin in Texas. After hearing presentations by US Department of Energy staff and consultants, and reviewing existing literature, they formed a conceptual model of basin flow that is downward across the salt facies and downdip in permeable formation in the lower hydrostratigraphic unit. Flow volumes and rates are very low. The panel examined several possible fracture-flow scenarios and concluded that flow within the salt section is probably porous-media-dominated with some fracture-flow influence in brittle zones. Fracture flow in the salt itself is rejected as a possibility based on current evidence. However, the panel recommended that fracture flow in the system should be included as a low-probability variable in any hydrogeologic modeling. They also concluded that many more data on lineament features and subsurface structures are needed to accurately characterize the system and to refine the modeling effort. 9 refs., 2 figs

De Doop met de Heilige Geest

Directory of Open Access Journals (Sweden)

S. C.W. Duvenage.

1965-03-01

Full Text Available Ds. Molenaar begin sy boek, waarvan hy self die publikasienie beleef het nie, deur te wys op 'n groot tekort, ’n manko,nie alleen in die Gereformeerde vroomheid of lewe nie maarook in die Gereformeerde teologie. Hy beskou dit as hoogsmerkwaardig dat die Gereformeerde teologie in die verledeso goed as niks raakgesien het van die groot betekenis vandie sogenaamde doop met die Heilige Gees nie. Daarby meenhy dat die Gereformeerde predikante verleë sit met die Pinkterfees.Talle probleme meen hy vir die Gereformeerde teoloograak te sien, veral ten aansien van die moontlikhede van dieGees teenoor die so tasbare „onmoontIikhede” in ons lewe. Dieprobleme is syns insiens nie onoplosbaar nie, as mens maardie moontlikhede van die Gees nie beperk tot die verlede nie.

c-MET Overexpression in Colorectal Cancer: A Poor Prognostic Factor for Survival.

Science.gov (United States)

Lee, Su Jin; Lee, Jeeyun; Park, Se Hoon; Park, Joon Oh; Lim, Ho Yeong; Kang, Won Ki; Park, Young Suk; Kim, Seung Tae

2018-03-02

Increased mesenchymal-epithelial transition factor gene (c-MET) expression in several human malignancies is related to increased tumor progression and is a new potential drug target for several types of cancers. In the present study, we investigated the incidence of c-MET overexpression and its prognostic significance in patients with colorectal cancer (CRC). We retrospectively reviewed the data from 255 stage IV CRC patients who had results from a c-MET immunohistochemical test at Samsung Medical Center. We explored the relationships between c-MET overexpression and clinicopathological features and survival. Primary tumor sites were 67 right-sided colon, 98 left-sided colon, and 90 rectum. Forty-two patients (16.7%) had poorly differentiated or mucinous carcinoma. Among the 255 patients, 39 (15.3%) exhibited c-MET overexpression. There was no significant difference in the prevalence of c-MET overexpression according to primary site, histologic differentiation, molecular markers, or metastatic sites. In a comparison of the tumor response to first-line chemotherapy according to the level of c-MET expression, we found no significant difference in either partial response or disease control rate. In the survival analysis, patients with c-MET overexpression had significantly shorter overall survival (39 vs. 27 months; P = .018) and progression-free survival (PFS) during bevacizumab treatment (10 vs. 7 months; P = .024). c-MET overexpression, which was detected in 39 CRC patients (15.3%) irrespective of primary sites or molecular markers, indicated a poor survival prognosis and predicted shorter PFS during bevacizumab treatment in patients with CRC. Further studies are warranted to elucidate the value of c-MET-targeted therapy in CRC patients. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Role of cMET in the Development and Progression of Colorectal Cancer

Directory of Open Access Journals (Sweden)

Ilaria Bossi

2013-09-01

Full Text Available Mesenchymal-epithelial transition (MET is a member of a distinct subfamily of heterodimeric receptor tyrosine kinase receptors that specifically binds the hepatocyte growth factor (HGF. Binding to HGF leads to receptor dimerization/multimerization and phosphorylation, resulting in its catalytic activation. MET activation drives the malignant progression of several tumor types, including colorectal cancer (CRC, by promoting signaling cascades that mainly result in alterations of cell motility, survival, and proliferation. MET is aberrantly activated in many human cancers through various mechanisms, including point mutations, gene amplification, transcriptional up-regulation, or ligand autocrine loops. MET promotes cell scattering, invasion, and protection from apoptosis, thereby acting as an adjuvant pro-metastatic gene for many tumor types. In CRC, MET expression confers more aggressiveness and worse clinical prognosis. With all of this rationale, inhibitors that target the HGF/MET axis with different types of response have been developed. HGF and MET are new promising targets to understand the pathogenesis of CRC and for the development of new, targeted therapies.

Fosfaatwerking ogranische meststoffen vergelijkbaar met kunstmest

NARCIS (Netherlands)

Ehlert, P.A.I.; Pasterkamp, H.P.

2000-01-01

Gegevens in bijgaande tabel: Indicatieve fosfaatgehalten en de relatieve verdeling over mineraalfosfaat en organisch gebonden fosfaat in meststoffen met per mestsoort gegevens over het totaal fosfaatgehalte, het percentage mineraal fosfaat en het percentage organisch fosfaat

User-Defined Meteorological (MET) Profiles from Climatological and Extreme Condition Data

Science.gov (United States)

2018-04-01

ARL-TN-0876 ● MAR 2018 US Army Research Laboratory User-Defined Meteorological (MET) Profiles from Climatological and Extreme...needed. Do not return it to the originator. ARL-TN-0876 ● MAR 2018 US Army Research Laboratory User-Defined Meteorological (MET...User-Defined Meteorological (MET) Profiles from Climatological and Extreme Condition Data 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

Forwarding techniques for IP fragmented packets in a real 6LoWPAN network.

Science.gov (United States)

Ludovici, Alessandro; Calveras, Anna; Casademont, Jordi

2011-01-01

Wireless Sensor Networks (WSNs) are attracting more and more interest since they offer a low-cost solution to the problem of providing a means to deploy large sensor networks in a number of application domains. We believe that a crucial aspect to facilitate WSN diffusion is to make them interoperable with external IP networks. This can be achieved by using the 6LoWPAN protocol stack. 6LoWPAN enables the transmission of IPv6 packets over WSNs based on the IEEE 802.15.4 standard. IPv6 packet size is considerably larger than that of IEEE 802.15.4 data frame. To overcome this problem, 6LoWPAN introduces an adaptation layer between the network and data link layers, allowing IPv6 packets to be adapted to the lower layer constraints. This adaptation layer provides fragmentation and header compression of IP packets. Furthermore, it also can be involved in routing decisions. Depending on which layer is responsible for routing decisions, 6LoWPAN divides routing in two categories: mesh under if the layer concerned is the adaptation layer and route over if it is the network layer. In this paper we analyze different routing solutions (route over, mesh under and enhanced route over) focusing on how they forward fragments. We evaluate their performance in terms of latency and energy consumption when transmitting IP fragmented packets. All the tests have been performed in a real 6LoWPAN implementation. After consideration of the main problems in forwarding of mesh frames in WSN, we propose and analyze a new alternative scheme based on mesh under, which we call controlled mesh under.

Forwarding Techniques for IP Fragmented Packets in a Real 6LoWPAN Network

Directory of Open Access Journals (Sweden)

Jordi Casademont

2011-01-01

Full Text Available Wireless Sensor Networks (WSNs are attracting more and more interest since they offer a low-cost solution to the problem of providing a means to deploy large sensor networks in a number of application domains. We believe that a crucial aspect to facilitate WSN diffusion is to make them interoperable with external IP networks. This can be achieved by using the 6LoWPAN protocol stack. 6LoWPAN enables the transmission of IPv6 packets over WSNs based on the IEEE 802.15.4 standard. IPv6 packet size is considerably larger than that of IEEE 802.15.4 data frame. To overcome this problem, 6LoWPAN introduces an adaptation layer between the network and data link layers, allowing IPv6 packets to be adapted to the lower layer constraints. This adaptation layer provides fragmentation and header compression of IP packets. Furthermore, it also can be involved in routing decisions. Depending on which layer is responsible for routing decisions, 6LoWPAN divides routing in two categories: mesh under if the layer concerned is the adaptation layer and route over if it is the network layer. In this paper we analyze different routing solutions (route over, mesh under and enhanced route over focusing on how they forward fragments. We evaluate their performance in terms of latency and energy consumption when transmitting IP fragmented packets. All the tests have been performed in a real 6LoWPAN implementation. After consideration of the main problems in forwarding of mesh frames in WSN, we propose and analyze a new alternative scheme based on mesh under, which we call controlled mesh under.

Rocket experiment METS - Microwave Energy Transmission in Space

Science.gov (United States)

Kaya, N.; Matsumoto, H.; Akiba, R.

A Microwave Energy Transmission in Space (METS) rocket experiment is being planned by the Solar Power Satellite Working Group at the Institute of Space and Astronautical Science in Japan for the forthcoming International Space Year, 1992. The METS experiment is an advanced version of the previous MINIX rocket experiment (Matsumoto et al., 1990). This paper describes a conceptual design of the METS rocket experiment. It aims at verifying a newly developed microwave energy transmission system for space use and to study nonlinear effects of the microwave energy beam in the space plasma environment. A high power microwave of 936 W will be transmitted by the new phased-array antenna from a mother rocket to a separated target (daughter rocket) through the ionospheric plasma. The active phased-array system has a capability of focusing the microwave energy around any spatial point by controlling the digital phase shifters individually.

Rocket experiment METS Microwave Energy Transmission in Space

Science.gov (United States)

Kaya, N.; Matsumoto, H.; Akiba, R.

A METS (Microwave Energy Transmission in Space) rocket experiment is being planned by the SPS (Solar Power Satellite) Working Group at the Institute of Space and Astronautical Science (ISAS) in Japan for the forthcoming International Space Year (ISY), 1992. The METS experiment is an advanced version of our MINIX rocket experiment. This paper describes the conceptual design for the METS rocket experiment. Aims are to verify the feasibility of a newly developed microwave energy transmission system designed for use in space and to study nonlinear effects of the microwave energy beam on space plasma. A high power microwave (936 W) will be transmitted by a new phase-array antenna from a mother rocket to a separate target (daughter rocket) through the Earth's ionospheric plasma. The active phased-array system has the capability of being able to focus the microwave energy at any spatial point by individually controlling the digital phase shifters.

"LinkedIn" loma Latvijas studentu sociālo mediju lietošanas paradumos

OpenAIRE

Mickēvičs, Rihards

2013-01-01

Bakalaura darbā „"LinkedIn" loma Latvijas studentu sociālo mediju lietošanas paradumos” aplūkots mērķa grupas kopējās interneta un sociālo mediju patēriņa tendences, komunikācijas rīku lietojums, vietnes „LinkedIn” loma Latvijas studentu sociālo mediju lietošanas aspektā un sava personīgā sociālā zīmola apzināšanās. Darbs balstīts uz četrām galvenajām daļām – teorētisko, metodoloģisko, empīrisko un rezultātu. Pamatojoties uz pieejamo teorētisko bāzi saistībā ar attiecīgo tēmu, tika veikta fok...

{sup 11}C-MET PET/MRI for detection of recurrent glioma

Energy Technology Data Exchange (ETDEWEB)

Deuschl, C. [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); Kirchner, J.; Schaarschmidt, B. [University Duesseldorf, Department of Diagnostic and Interventional Radiology, Medical Faculty, Duesseldorf (Germany); Poeppel, T.D.; Herrmann, K. [University Hospital Essen, Clinic for Nuclear Medicine, Essen (Germany); Kebir, S.; Glas, M. [University Hospital Essen, Division of Clinical Neurooncology, Department of Neurology, Essen (Germany); El Hindy, N. [University Hospital Essen, Department of Neurosurgery, Essen (Germany); Hense, J. [University Hospital Essen, Department of Medical Oncology, West German Cancer Center, Essen (Germany); Quick, H.H. [University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); University Hospital Essen, High Field and Hybrid MR Imaging, Essen (Germany); Umutlu, L.; Moenninghoff, C.; Radbruch, A.; Forsting, M. [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Schlamann, M. [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University Hospital Cologne, Department of Diagnostic and Interventional Radiology, Cologne (Germany)

2018-04-15

Radiological assessment of brain tumors is widely based on the Radiology Assessment of Neuro-Oncology (RANO) criteria that consider non-specific T1 and T2 weighted images. Limitation of the RANO criteria is that they do not include metabolic imaging techniques that have been reported to be helpful to differentiate treatment related changes from true tumor progression. In the current study, we assessed if the combined use of MRI and PET with hybrid {sup 11}C-MET PET/MRI can improve diagnostic accuracy and diagnostic confidence of the readers to differentiate treatment related changes from true progression in recurrent glioma. Fifty consecutive patients with histopathologically proven glioma were prospectively enrolled for a hybrid {sup 11}C-MET PET/MRI to differentiate recurrent glioma from treatment induced changes. Sole MRI data were analyzed based on RANO. Sole PET data and in a third evaluation hybrid {sup 11}C-MET-PET/MRI data were assessed for metabolic respectively metabolic and morphologic glioma recurrence. Diagnostic performance and diagnostic confidence of the reader were calculated for the different modalities, and the McNemar test and Mann-Whitney U Test were applied for statistical analysis. Hybrid {sup 11}C-MET PET/MRI was successfully performed in all 50 patients. Glioma recurrence was diagnosed in 35 of the 50 patients (70%). Sensitivity and specificity were calculated for MRI (86.11% and 71.43%), for {sup 11}C-MET PET (96.77% and 73.68%), and for hybrid {sup 11}C-MET-PET/MRI (97.14% and 93.33%). For diagnostic accuracy hybrid {sup 11}C-MET-PET/MRI (96%) showed significantly higher values than MRI alone (82%), whereas no significant difference was found for 11C-MET PET (88%). Furthermore, by rating on a five-point Likert scale significantly higher scores were found for diagnostic confidence when comparing {sup 11}C-MET PET/MRI (4.26 ± 0,777) to either PET alone (3.44 ± 0.705) or MRI alone (3.56 ± 0.733). This feasibility study showed that hybrid

Lo que la literatura puede aportar a la psicología social

OpenAIRE

Ovejero, Anastasio

2013-01-01

Existen básicamente dos tipos de psicología. Una psicología intuitiva y una psicología académica y profesional. Aunque las dos van por caminos diferentes, no tienen por qué contradecirse. Por el contrario, pueden apoyarse mutuamente. A mi entender, lo mejor de la psicología intuitiva, que se encuentra en la literatura y particularmente en la novela, puede serles de gran ayuda a los psicólogos académicos y profesionales. Pues bien, lo que en este trabajo se pretende es mostrar argumentos a fav...

'Epistemology models ontology'− In gesprek met John Polkinghorne

African Journals Online (AJOL)

Test

7 Jun 2011 ... maar met die aard daarvan. Polkinghorne wil met sy boek One World (1996) presies sê wat die titel suggereer. Hiervoor kry hy die oplossing by sy mentor en latere kollega, Paul Dirac. Vir meer as 30 jaar het Dirac dieselfde leerstoel in Fisika aan Cambridge beklee as Isaac Newton (Polkinghorne 2005:34).

La construcción social de lo rural

Directory of Open Access Journals (Sweden)

María Teresa Matijasevic Arcila

2013-04-01

Full Text Available La investigación social apela frecuentemente a la noción rural, bien sea para delimitar el territorio objeto de estudio o para aludir a una forma de vida. El análisis de las distintas perspectivas que confluyen en la construcción de esta noción es el propósito de este artículo. Se acude para ello a las formulaciones realizadas por distintos autores respecto a las principales tendencias contemporáneas sobre la ruralidad: lo rural como signo de atraso, el continuum rural-urbano, la desruralización, la fusión urbano-rural, el reencuentro con la vida rural y la nueva ruralidad. Se presentan, asimismo, los indicadores oficiales utilizados en América Latina para medir la ruralidad o para referirse a ella en términos técnicos, sociales o políticos, así como algunas reflexiones sobre las relaciones entre estas mediciones y las perspectivas conceptuales analizadas. Finalmente, se plantea una serie de consideraciones, a manera de retos actuales, frente a la necesidad de construir reconceptualizaciones y metodologías más potentes e incluyentes sobre lo rural.

La trampa del antropomorfismo. Hacia una interfaz (más compleja de lo social

Directory of Open Access Journals (Sweden)

Iñaki Martínez de Albeniz

2010-11-01

Full Text Available La enseñanza de la sociología supone, hoy día, una cura de humildad. Por más que acudamos a sofisticados modelos teóricos (la sociedad líquida, la teoría de sistemas, la fluidez social, la teoría del actor-red, que cuestionan las bases fundacionales de la sociología clásica, la práctica docente evidencia que entre los estudiantes sigue imperando una imagen simple o esquemática de lo social. La sorpresa es mayor si asumimos que se trata de una generación que se ha socializado en el uso de herramientas digitales que facilitan, en principio, la elaboración de mapas más acordes con la complejidad que lo social reviste. El antropomorfismo, la idea de que la sociedad es ante todo un agrupamiento más o menos estable de individuos, es el límite infranqueable que sigue imponiéndose a la hora de entender lo social. Para minar esta visión hegemónica es preciso acudir a disciplinas como el arte (digital, las nuevas tecnología y, en general, las innovaciones estéticas, no tanto para destruir esa representación antropomórfica de lo social sino para desfigurándola prefigurar otras más acordes con una complejidad que ya no sólo intuimos y cuyo aliento sentimos muy cerca.

The applications of 11C-MET PET in brain tumor

International Nuclear Information System (INIS)

Hua Fengchun

2002-01-01

11 C-methionine (MET), an amino acid, is the most widely used radio pharmaceutics which can reflect transport metabolism of amino acid in vivo, and synthesis of protein in tumor. 11 C-MET PET can be used for evaluation of brain tumor: detection of tumor, differential diagnosis between recurrence and radiation necrosis and early evaluation of response to treatment. Especially, for the definition of tumor margin and detection of low-grade tumors, PET with 11 C-MET is better than PET with 18 F-FDG or other modalities such as CT and MRI

Estructuras Metálicas

Directory of Open Access Journals (Sweden)

Hidalgo Fernández-Cano, Amalio

1960-01-01

Full Text Available Se compone de dos naves adosadas de 20,80 m de luz y una longitud de 252 m. Existe un adosado de dos plantas donde se recogen las oficinas y los servicios del taller. Las naves están servidas por puentes-grúa de 25 t y por grúas de pescante, lo que da lugar a la presencia de vigas de rodadura a dos niveles distintos. La cubierta apoya sobre arcos triarticulados atirantados; los semiarcos se prolongan a partir de la clave en piezas inclinadas que sirven para constituir lucernarios alternados. Al igual que en los talleres mecánicos y de fundición, todos los elementos de cubierta fueron prefabricados.

Milde voedselverwerkingstechnologie II : milde conservering met hoge druk : nieuwe ontwikkelingen

NARCIS (Netherlands)

Matser, A.M.; Ven, van der C.; Berg, van den R.

2004-01-01

Met behulp van hogedruktechnologie kunnen producten langer houdbaar worden gemaakt. Deze bekende techniek kent de laatste tijd nieuwe ontwikkelingen en toepassingen . Naast pasteuriseren door een hogedrukbehandeling bij kamertemperatuur is het nu ook mogelijk om te steriliseren met hoge druk. Ook

Bio-composiet : Thermoplastische kunsstof met natuurvezels

NARCIS (Netherlands)

Beurden, van K.M.M. (Karin); Goselink, E.A. (Erik)

2013-01-01

Een biocomposiet wordt samengesteld uit een vezel en een hars. In dit document worden twee verwerkingsvormen van biocomposieten behandeld: - Vezel/poeder versterkt kunststof (granulaat); - Kunststof plaatmateriaal versterkt met een weefsel (laminaat), ook wel Sizopreg® genoemd. Door een

Technisch lego met een Duplo-interface

NARCIS (Netherlands)

Pimentel, A.; Schipper, D.

2008-01-01

Daedalus is een ontwerpflow op systeemniveau waarmee techneuten snel kunnen experimenteren met verschillende multiprocessorarchitecturen tijdens de vroege stadia van het ontwerptraject. Het is het resultaat van tien jaar onderzoek en ontwikkeling binnen de Progress-projecten Artemis en Artemisia.

MET and Small-Cell Lung Cancer

Directory of Open Access Journals (Sweden)

Francesco Gelsomino

2014-10-01

Full Text Available Small-cell lung cancer (SCLC is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.

Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis.

Science.gov (United States)

Bozkaya, Giray; Korhan, Peyda; Cokaklı, Murat; Erdal, Esra; Sağol, Ozgül; Karademir, Sedat; Korch, Christopher; Atabey, Neşe

2012-09-11

Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has been correlated with aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC). MUC1 is a transmembrane mucin, whose over-expression is reported in most cancers. Many of the oncogenic effects of MUC1 are believed to occur through the interaction of MUC1 with signaling molecules. To clarify the role of MUC1 in HGF/c-Met signaling, we determined whether MUC1 and c-Met interact cooperatively and what their role(s) is in hepatocarcinogenesis. MUC1 and c-Met over-expression levels were determined in highly motile and invasive, mesenchymal-like HCC cell lines, and in serial sections of cirrhotic and HCC tissues, and these levels were compared to those in normal liver tissues. Co-expression of both c-Met and MUC1 was found to be associated with the differentiation status of HCC. We further demonstrated an interaction between c-Met and MUC1 in HCC cells. HGF-induced c-Met phosphorylation decreased this interaction, and down-regulated MUC1 expression. Inhibition of c-Met activation restored HGF-mediated MUC1 down-regulation, and decreased the migratory and invasive abilities of HCC cells via inhibition of β-catenin activation and c-Myc expression. In contrast, siRNA silencing of MUC1 increased HGF-induced c-Met activation and HGF-induced cell motility and invasion. These findings indicate that the crosstalk between MUC1 and c-Met in HCC could provide an advantage for invasion to HCC cells through the β-catenin/c-Myc pathway. Thus, MUC1 and c-Met could serve as potential therapeutic targets in HCC.

c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma

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Granito A

2015-04-01

Full Text Available Alessandro Granito,1 Elena Guidetti,1 Laura Gramantieri2,3 1Dipartimento di Scienze Mediche e Chirurgiche Università di Bologna, Bologna, Italy; 2Dipartimento dell'Apparato Digerente, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Centro di Ricerca Biomedica Applicata (CRBA, Azienda Ospedaliero-Universitaria Policlinico S Orsola-Malpighi e Università di Bologna, Bologna, Italy Abstract: c-MET is the membrane receptor for hepatocyte growth factor (HGF, also known as scatter factor or tumor cytotoxic factor, a mitogenic growth factor for hepatocytes. HGF is mainly produced by cells of mesenchymal origin and it mainly acts on neighboring epidermal and endothelial cells, regulating epithelial growth and morphogenesis. HGF/MET signaling has been identified among the drivers of tumorigenesis in human cancers. As such, c-MET is a recognized druggable target, and against it, targeted agents are currently under clinical investigation. c-MET overexpression is a common event in a wide range of human malignancies, including gastric, lung, breast, ovary, colon, kidney, thyroid, and liver carcinomas. Despite c-MET overexpression being reported by a large majority of studies, no evidence for a c-MET oncogenic addiction exists in hepatocellular carcinoma (HCC. In particular, c-MET amplification is a rare event, accounting for 4%–5% of cases while no mutation has been identified in c-MET oncogene in HCC. Thus, the selection of patient subgroups more likely to benefit from c-MET inhibition is challenging. Notwithstanding, c-MET overexpression was reported to be associated with increased metastatic potential and poor prognosis in patients with HCC, providing a rationale for its therapeutic inhibition. Here we summarize the role of activated HGF/MET signaling in HCC, its prognostic relevance, and the implications for therapeutic approaches in HCC. Keywords: hepatocellular carcinoma, c-MET, clinical trials

Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis

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Bozkaya Giray

2012-09-01

Full Text Available Abstract Background Hepatocyte growth factor (HGF induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has been correlated with aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC. MUC1 is a transmembrane mucin, whose over-expression is reported in most cancers. Many of the oncogenic effects of MUC1 are believed to occur through the interaction of MUC1 with signaling molecules. To clarify the role of MUC1 in HGF/c-Met signaling, we determined whether MUC1 and c-Met interact cooperatively and what their role(s is in hepatocarcinogenesis. Results MUC1 and c-Met over-expression levels were determined in highly motile and invasive, mesenchymal-like HCC cell lines, and in serial sections of cirrhotic and HCC tissues, and these levels were compared to those in normal liver tissues. Co-expression of both c-Met and MUC1 was found to be associated with the differentiation status of HCC. We further demonstrated an interaction between c-Met and MUC1 in HCC cells. HGF-induced c-Met phosphorylation decreased this interaction, and down-regulated MUC1 expression. Inhibition of c-Met activation restored HGF-mediated MUC1 down-regulation, and decreased the migratory and invasive abilities of HCC cells via inhibition of β-catenin activation and c-Myc expression. In contrast, siRNA silencing of MUC1 increased HGF-induced c-Met activation and HGF-induced cell motility and invasion. Conclusions These findings indicate that the crosstalk between MUC1 and c-Met in HCC could provide an advantage for invasion to HCC cells through the β-catenin/c-Myc pathway. Thus, MUC1 and c-Met could serve as potential therapeutic targets in HCC.

Extraboard performance : TriMet case study.

Science.gov (United States)

2012-02-01

This paper examines extraboard operations and management at TriMet, the transit provider for the Portland Oregon metropolitan area. The : extraboard consists of a pool of operators who fill open work resulting from absences and other causes. The pape...

Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus.

Science.gov (United States)

Kim, Sun-Young; Jo, Dae-Sun; Hwang, Pyoung Han; Park, Ji Hyun; Park, Sung Kwang; Yi, Ho Keun; Lee, Dae-Yeol

2006-03-01

Ghrelin is a novel gut-brain peptide, which exerts somatotropic, orexigenic, and adipogenic effects. Genetic variants of ghrelin have been associated with both obesity and insulin metabolism. In this study, we determined a role of preproghrelin Leu72Met polymorphism on type 2 diabetes mellitus and its relationship to variables studied. Genotypes were assessed by polymerase chain reaction. Frequencies of the Leu72Met polymorphism were found to be 35.4% in the type 2 diabetic patients and 32.5% in the normal controls. The Leu72Met polymorphism was not associated with hypertension, macroangiopathy, retinopathy, serum cholesterol, triglyceride, blood urea nitrogen, HbA(1c), lipoprotein (a), fasting insulin, or 24-hour urinary protein levels in the type 2 diabetic group. However, the Leu72Met polymorphism was clearly associated with serum creatinine levels in the diabetic group, as the Met72 carriers exhibited lower serum creatinine levels than the Met72 noncarriers. Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus. However, the Leu72Met polymorphism is associated with serum creatinine levels. These data suggest that Met72 carrier status may be a predictable marker for diabetic nephropathy or renal impairment in type 2 diabetes mellitus.

El interrogante de lo vivo y sus respuestas ahistóricas: desarrollo histórico del concepto de lo vivo y algunas implicaciones didácticas.

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Mónica Correa (Página 153-163

2009-07-01

Full Text Available El  presente trabajo muestra  el desarrollo histórico y epistemológico del concepto de lo vivo, en términos de las diferentes corrientes de pensamiento que han guiado su estudio, como son: El animismo, el mecanicismo, el vitalismo, el organicismo, el pensamiento sistémico y el neomecanicismo. Además, relacionando lo  anterior con  la formación docente y buscando una reflexión acerca de la importancia de vincular la historia y la epistemología en la enseñanza de las ciencias, se hace una revisión de algunas  implicaciones  didácticas del abordaje ahistórico de de este concepto en la escuela.

Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530). Supplement No. 7

International Nuclear Information System (INIS)

1984-12-01

Supplement No. 7 to the Safety Evaluation Report for the application filed by Arizona Public Service Company et al. for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizona, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of: (1) additional information submitted by the applicant since Supplement No. 6 was issued; and (2) matters that the staff had under review when Supplement No. 6 was issued

c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target.

Science.gov (United States)

Ozawa, Yohei; Nakamura, Yasuhiro; Fujishima, Fumiyoshi; Felizola, Saulo J A; Takeda, Kenichiro; Okamoto, Hiroshi; Ito, Ken; Ishida, Hirotaka; Konno, Takuro; Kamei, Takashi; Miyata, Go; Ohuchi, Noriaki; Sasano, Hironobu

2015-06-03

c-Met is widely known as a poor prognostic factor in various human malignancies. Previous studies have suggested the involvement of c-Met and/or its ligand, hepatocyte growth factor (HGF), in esophageal squamous cell carcinoma (ESCC), but the correlation between c-Met status and clinical outcome remains unclear. Furthermore, the identification of a novel molecular therapeutic target might potentially help improve the clinical outcome of ESCC patients. The expression of c-Met and HGF was immunohistochemically assessed in 104 surgically obtained tissue specimens. The correlation between c-Met/HGF expression and patients' clinicopathological features, including survival, was evaluated. We also investigated changes in cell functions and protein expression of c-Met and its downstream signaling pathway components under treatments with HGF and/or c-Met inhibitor in ESCC cell lines. Elevated expression of c-Met was significantly correlated with tumor depth and pathological stage. Patients with high c-Met expression had significantly worse survival. In addition, multivariate analysis identified the high expression of c-Met as an independent prognostic factor. Treatment with c-Met inhibitor under HGF stimulation significantly inhibited the invasive capacity of an ESCC cell line with elevated c-Met mRNA expression. Moreover, c-Met and its downstream signaling inactivation was also detected after treatment with c-Met inhibitor. The results of our study identified c-Met expression as an independent prognostic factor in ESCC patients and demonstrated that c-Met could be a potential molecular therapeutic target for the treatment of ESCC with elevated c-Met expression.

A brief report on mets system

Digital Repository Service at National Institute of Oceanography (India)

Fernandes, W.A.

Mets system is basically a gas monitoring system, used for the detection of underwater gas. The system consists of a sensor, datalogger and energy module. The sensor works on the diffusion techniques. The system can be deployed to a water depth...

Lo relativo y lo universal en la defensa de las humanidades para la democracia

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Liliana Galindo

2015-09-01

Full Text Available Cuando se pone en duda la importancia del estudio de las humanidades aparecen varios argumentos en su defensa. En este ensayo se analiza uno de ellos: la democracia las necesita. A partir del modelo educativo para la democracia que Martha Nussbaum propone en Sin fines de lucro: por qué la democracia necesita de las humanidades se explora la noción de educación liberal, la necesidad de la democracia y la idea de humanidad que aparecen en este argumento, con el fin de preguntarnos sobre la importancia que se le da al estudio especializado de las humanidades en la educación superior, lo que se entiende por ellas, su autonomía frente a su función para la democracia, y la manera en que educan la forma en que vemos a los otros y nos relacionamos con ellos. 

Podemos como un acontecimiento o no: lo que vemos desde Manchester

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Ian Parker

2015-04-01

Full Text Available En este artículo se analiza a Podemos desde la noción de “acontecimiento” teorizada por Alain Badiou y sobre la base de dos cuestiones que se relacionan con Podemos como fenómeno anti-político. En primer lugar, en lo relativo a la relación entre discurso académico y acontecimientos políticos, llegando a la conclusión de que tanto Badiou como el grupo de la Complutense que rodea a Iglesias intervinieron con éxito sobre el mundo real, desde la Universidad, desde un marco académico. La segunda cuestión tiene que ver con el modo en que nos relacionamos con acontecimientos que aun no han ocurrido. Parker concluye que el futuro de Podemos está íntimamente ligado a lo que pueda ocurrir en Grecia tras la victoria de Syriza. En este artículo se describe el impacto positivo que ha tenido Podemos para el “Left Unity” en Manchester y se aboga por un compromiso con ambas formaciones más allá de lo puramente académico. Podemos y Syriza son posibles acontecimientos cuyo carácter está aún por determinar, y cuyas implicaciones traspasan incluso las fronteras de Europa.

The potential roles of hepatocyte growth factor (HGF-MET pathway inhibitors in cancer treatment

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Parikh RA

2014-06-01

Full Text Available Rahul A Parikh,1 Peng Wang,2 Jan H Beumer,3 Edward Chu,1 Leonard J Appleman11Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; 2Division of Medical Oncology, University of Kentucky College of Medicine, Markey Cancer Center, Lexington, KY, USA; 3University of Pittsburgh School of Pharmacy, Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USAAbstract: MET is located on chromosome 7q31 and is a proto-oncogene that encodes for hepatocyte growth factor (HGF receptor, a member of the receptor tyrosine kinase (RTK family. HGF, also known as scatter factor (SF, is the only known ligand for MET. MET is a master regulator of cell growth and division (mitogenesis, mobility (motogenesis, and differentiation (morphogenesis; it plays an important role in normal development and tissue regeneration. The HGF-MET axis is frequently dysregulated in cancer by MET gene amplification, translocation, and mutation, or by MET or HGF protein overexpression. MET dysregulation is associated with an increased propensity for metastatic disease and poor overall prognosis across multiple tumor types. Targeting the dysregulated HGF-MET pathway is an area of active research; a number of monoclonal antibodies to HGF and MET, as well as small molecule inhibitors of MET, are under development. This review summarizes the key biological features of the HGF-MET axis, its dysregulation in cancer, and the therapeutic agents targeting the HGF-MET axis, which are in development.Keywords: MET inhibitor, HGF inhibitor, cancer

75 FR 1007 - MetLife, Inc. and MetLife Capital Trust V; Notice of Application

Science.gov (United States)

2010-01-07

... the definition of investment company by section 3(b) of the Act or by the rules or regulations under... Act for an exclusion from the definition of an investment company. To the extent MetLife or another... definition of a ``parent company'' in rule 3a-5(b)(2)(i) solely because it is an ``insurance company'' or...

Brain-derived neurotrophic factor Val66Met genotype modulates amygdala habituation.

Science.gov (United States)

Perez-Rodriguez, M Mercedes; New, Antonia S; Goldstein, Kim E; Rosell, Daniel; Yuan, Qiaoping; Zhou, Zhifeng; Hodgkinson, Colin; Goldman, David; Siever, Larry J; Hazlett, Erin A

2017-05-30

A deficit in amygdala habituation to repeated emotional stimuli may be an endophenotype of disorders characterized by emotion dysregulation, such as borderline personality disorder (BPD). Amygdala reactivity to emotional stimuli is genetically modulated by brain-derived neurotrophic factor (BDNF) variants. Whether amygdala habituation itself is also modulated by BDNF genotypes remains unknown. We used imaging-genetics to examine the effect of BDNF Val66Met genotypes on amygdala habituation to repeated emotional stimuli. We used functional magnetic resonance imaging (fMRI) in 57 subjects (19 BPD patients, 18 patients with schizotypal personality disorder [SPD] and 20 healthy controls [HC]) during a task involving viewing of unpleasant, neutral, and pleasant pictures, each presented twice to measure habituation. Amygdala responses across genotypes (Val66Met SNP Met allele-carriers vs. Non-Met carriers) and diagnoses (HC, BPD, SPD) were examined with ANOVA. The BDNF 66Met allele was significantly associated with a deficit in amygdala habituation, particularly for emotional pictures. The association of the 66Met allele with a deficit in habituation to unpleasant emotional pictures remained significant in the subsample of BPD patients. Using imaging-genetics, we found preliminary evidence that deficient amygdala habituation may be modulated by BDNF genotype. Copyright © 2017. Published by Elsevier B.V.

Catechol-O-Methyltransferase (COMT) Gene (Val158Met) and Brain-Derived Neurotropic Factor (BDNF) (Val66Met) Genes Polymorphism in Schizophrenia: A Case-Control Study.

Science.gov (United States)

Saravani, Ramin; Galavi, Hamid Reza; Lotfian Sargazi, Marzieh

2017-10-01

Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ). In the present study, we aimed at examining the effects of COMT Val158Met (G>A) and BDNF Val66Met (G>A) polymorphisms on SCZ risk in a sample of Iranian population. Method: This case- control study included 92 SCZ patients and 92 healthy controls (HCs). Genotyping of both variants (COMT Val158Met (G>A) and BDNF Val66Met (G>A)) were conducted using Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR). Results: The findings revealed that the COMT Val158Met (G>A) polymorphism was not associated with the risk/protective of SCZ in all models (OR=0.630, 95%CI=0.299-1.326, P=0.224, GA vs. GG, OR=1.416, 95%CI=0.719-2.793, P=0.314, AA vs. GG, OR=1.00, 95%CI=0.56-1.79, P=1.00 GA+AA vs. GG, OR=1.667, 95%CI=0.885-3.125, P=0.11, AA vs. GG+GA, OR=1.247, 95%CI=0.825-1.885, P=0.343, A vs. G,). However, BDNF Val66Met (G>A) variant increased the risk of SCZ (OR = 2.008 95%CI = 1.008-4.00, P = 0.047, GA vs. GG, OR = 3.876 95%CI = 1.001-14.925, P = 0.049. AA vs. GG, OR = 2.272. 95%CI = 1.204-4.347, P = 0.011, GA+AA vs. GG, OR = 2.22 95%CI = 1.29-3.82. P = 0.005, A vs. G). Conclusion: The results did not support an association between COMT Val158Met (G>A) variant and risk/protective of SCZ. Moreover, it was found that BDNF Val66Met (G>A) polymorphism may increase the risk of SCZ development. Further studies and different ethnicities are recommended to confirm the findings.

BabeLO--An Extensible Converter of Programming Exercises Formats

Science.gov (United States)

Queiros, R.; Leal, J. P.

2013-01-01

In the last two decades, there was a proliferation of programming exercise formats that hinders interoperability in automatic assessment. In the lack of a widely accepted standard, a pragmatic solution is to convert content among the existing formats. BabeLO is a programming exercise converter providing services to a network of heterogeneous…

A Study of LoRa: Long Range & Low Power Networks for the Internet of Things.

Science.gov (United States)

Augustin, Aloÿs; Yi, Jiazi; Clausen, Thomas; Townsley, William Mark

2016-09-09

LoRa is a long-range, low-power, low-bitrate, wireless telecommunications system, promoted as an infrastructure solution for the Internet of Things: end-devices use LoRa across a single wireless hop to communicate to gateway(s), connected to the Internet and which act as transparent bridges and relay messages between these end-devices and a central network server. This paper provides an overview of LoRa and an in-depth analysis of its functional components. The physical and data link layer performance is evaluated by field tests and simulations. Based on the analysis and evaluations, some possible solutions for performance enhancements are proposed.

A Study of LoRa: Long Range & Low Power Networks for the Internet of Things

Directory of Open Access Journals (Sweden)

Aloÿs Augustin

2016-09-01

Full Text Available LoRa is a long-range, low-power, low-bitrate, wireless telecommunications system, promoted as an infrastructure solution for the Internet of Things: end-devices use LoRa across a single wireless hop to communicate to gateway(s, connected to the Internet and which act as transparent bridges and relay messages between these end-devices and a central network server. This paper provides an overview of LoRa and an in-depth analysis of its functional components. The physical and data link layer performance is evaluated by field tests and simulations. Based on the analysis and evaluations, some possible solutions for performance enhancements are proposed.

c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

International Nuclear Information System (INIS)

Ozawa, Yohei; Nakamura, Yasuhiro; Fujishima, Fumiyoshi; Felizola, Saulo JA; Takeda, Kenichiro; Okamoto, Hiroshi; Ito, Ken; Ishida, Hirotaka; Konno, Takuro; Kamei, Takashi; Miyata, Go; Ohuchi, Noriaki; Sasano, Hironobu

2015-01-01

c-Met is widely known as a poor prognostic factor in various human malignancies. Previous studies have suggested the involvement of c-Met and/or its ligand, hepatocyte growth factor (HGF), in esophageal squamous cell carcinoma (ESCC), but the correlation between c-Met status and clinical outcome remains unclear. Furthermore, the identification of a novel molecular therapeutic target might potentially help improve the clinical outcome of ESCC patients. The expression of c-Met and HGF was immunohistochemically assessed in 104 surgically obtained tissue specimens. The correlation between c-Met/HGF expression and patients’ clinicopathological features, including survival, was evaluated. We also investigated changes in cell functions and protein expression of c-Met and its downstream signaling pathway components under treatments with HGF and/or c-Met inhibitor in ESCC cell lines. Elevated expression of c-Met was significantly correlated with tumor depth and pathological stage. Patients with high c-Met expression had significantly worse survival. In addition, multivariate analysis identified the high expression of c-Met as an independent prognostic factor. Treatment with c-Met inhibitor under HGF stimulation significantly inhibited the invasive capacity of an ESCC cell line with elevated c-Met mRNA expression. Moreover, c-Met and its downstream signaling inactivation was also detected after treatment with c-Met inhibitor. The results of our study identified c-Met expression as an independent prognostic factor in ESCC patients and demonstrated that c-Met could be a potential molecular therapeutic target for the treatment of ESCC with elevated c-Met expression. The online version of this article (doi:10.1186/s12885-015-1450-3) contains supplementary material, which is available to authorized users

El tratamiento de la metáfora en la traducción de Historias de Tata Mundo (The Treatment of the Metaphor in the Translation of Historias de Tata Mundo

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Jacqueline Araya Ríos

2016-09-01

Full Text Available Fabián Dobles plantea mediante hechos característicos y regionalismos una imagen del campesino nacional de mediados de siglo xx en su obra Historias de Tata Mundo. Joan Henry lo traduce al inglés en 1998 y lo titula The Stories of Tata Mundo, transportando al campesino costarricense a la escena de habla inglesa. Se analizan las decisiones de la traductora sobre el tratamiento de las metáforas, teniendo en cuenta el lenguaje figurado como una herramienta empleada por el autor para caracterizar la vida rural del campesinado costarricense. Using traditional activities and regionalisms, Fabián Dobles reconstructed the image of the Costa Rican country folk of the mid-twentieth century in his literary work Historias de Tata Mundo. Joan Henry translated it in 1998, with the title The Stories of Tata Mundo, transporting the local peasant to the English-speaking scenario. The translator’s decisions are analyzed here regarding the translation of metaphors, taking into account figurative speech as a tool used by the author to characterize and depict the rural life of Costa Rican country folk.

Activating mutation in MET oncogene in familial colorectal cancer

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Schildkraut Joellen M

2011-10-01

Full Text Available Abstract Background In developed countries, the lifetime risk of developing colorectal cancer (CRC is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherited colon cancer syndromes account for approximately 5%, leaving greater than 20% without clear genetic definition. Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility. Methods MET exons were amplified by PCR from germline DNA of 148 affected sibling pairs with colorectal cancer. Amplicons with altered sequence were detected with high-resolution melt-curve analysis using a LightScanner (Idaho Technologies. Samples demonstrating alternative melt curves were sequenced. A TaqMan assay for the specific c.2975C >T change was used to confirm this mutation in a cohort of 299 colorectal cancer cases and to look for allelic amplification in tumors. Results Here we report a germline non-synonymous change in the MET proto-oncogene at amino acid position T992I (also reported as MET p.T1010I in 5.2% of a cohort of sibling pairs affected with CRC. This genetic variant was then confirmed in a second cohort of individuals diagnosed with CRC and having a first degree relative with CRC at prevalence of 4.1%. This mutation has been reported in cancer cells of multiple origins, including 2.5% of colon cancers, and in Conclusions Although the MET p.T992I genetic mutation is commonly found in somatic colorectal cancer tissues, this is the first report also implicating this MET genetic mutation as a germline inherited risk factor for familial colorectal cancer. Future studies on the cancer risks associated with this mutation and the prevalence in different at-risk populations will

Lo que se debe a las cimentaciones

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Oroviogoicoechea, Alberto

1975-05-01

Full Text Available This article describes: the problems that arise when the foundations has to act on soils with low consistency or when very narrow tolerances have to be met; the origin of the above mentioned problems; the requirements that are not really necessary, with suitable examples; the absolute and relative admissible magnitudes of differential settlements in concrete structures, walls, partitions and metal structures; the tolerances for mechanical installations; recommendations for projects and a table that sums up the proposed tolerances for relative foundations.En el artículo se describen: los problemas que surgen cuando la cimentación ha de actuar sobre terrenos poco consistentes o cuando se quieren cumplir tolerancias muy estrechas; de dónde provienen dichos problemas; las exigencias que no son realmente necesarias, con ejemplos apropiados; las magnitudes absolutas y relativas admisibles de asientos diferenciales, en estructuras de hormigón, muros, tabiques y estructuras metálicas; las tolerancias para instalaciones mecánicas; recomendaciones para proyecto, y una tabla que recoge las tolerancias propuestas para asientos relativos.

Varroabestrijding met bijenbroed als mijtenval (2)

NARCIS (Netherlands)

Calis, J.; Beetsma, J.; Boot, W.J.; Eijnde, van den J.; Ruijter, de A.

1994-01-01

Bij deze bestrijdingsmethode worden belegde darreraten uit een moergoede veger overgehangen naar het moerloze en later broedloze hoofdvolk. Hier worden de mijten die zich op de bijen bevinden gevangen. Nadat de laatste darreraat uit een hoofdvolk is verwijderd, wordt het bijenvolk met Perizine

Groen proceswater: zuivering brouwerijprocesafvalwater met microalgen

NARCIS (Netherlands)

Dijk, van W.; Weide, van der R.Y.; Kroon, A.

2016-01-01

In 2012 is het project Groen Proceswater gestart. Hierin worden de mogelijkheden van zuivering van brouwerijprocesafvalwater met behulp van microalgen onderzocht. Dit is gedaan in een samenwerkingsverband van Heineken Nederland BV, Algae Food & Fuel en WUR-ACRRES. De resultaten behaald in 2012

Risicoanalyse voor buisleidingen met brandbare vloeistoffen

NARCIS (Netherlands)

van Vliet AAC; Laheij GMH; Wolting AG; CEV

2006-01-01

De minimale veiligheidsafstanden tussen buisleidingen met brandbare vloeistoffen en bebouwingen kunnen gelijk blijven of iets verkleind worden. Dit is de conclusie na een herberekening van de afstanden uit een circulaire uit 1991. In Nederland ligt zo'n 1850 kilometer aan ondergrondse buisleiding

Características tecnológicas de la madera de palo morado (Peltogyne mexicana Martínez de tierra colorada, Guerrero, México

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J. Navarro-Martínez

2005-01-01

Full Text Available El presente trabajo contribuye al conocimiento de las características y propiedades tecnológicas de la madera de Palo morado (Peltogyne mexicana Martínez, mediante la caracterización anatómica, porcentaje de elementos y determinación de las propiedades físicas y tres mecánicas. Se colectaron dos árboles en Tierra Colorada Guerrero. El material se obtuvo de trozas a 1.30 m de altura. Para el estudio macroscópico se usaron muestras de 7 x 15 x 1 cm y para el microscópico se elaboraron preparaciones fijas de cortes y de material disociado. La madera presenta un color violeta intenso, porosidad difusa, parénquima en bandas y aliforme confluente con cristales, los elementos de vaso son cortos de diámetro medio, con inclusiones, rayos uniseriados, biseriados, triseriados y raramente multiseriados; las fibras son de tipo libriforme de longitud media, diámetro fino y pared gruesa, presenta densidad básica, contracciones y dureza alta.

MÁQUINAS CON ALMA. LO TÉCNICO Y LO HUMANO EN SIMONDON Y EN LA CULTURA DEL ANIME.

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Alba Gonzalez Torrents

2013-06-01

Full Text Available En el imaginario del anime contemporáneo de ciencia ficción encontramos algunos ejemplos claros de una reinterpretación de la relación entre ser humano y tecnología  en términos no-clásicos. La filosofía de la individuación de Gilbert Simondon, con su crítica radical al individualismo y al sustancialismo, y en especial su filosofía de la técnica, centrada en la denuncia del olvido cultural de los aspectos humanos de la técnica, ofrecen una clave filosófica idónea para la exploración de ese imaginario. Mediante la aplicación de los conceptos desarrollados por Simondon en sus análisis del modo de existencia de los objetos técnico a los animes Akira, Evangelion, Ghost in The Shell y Serial Experiments Lain, muestro que existe en ellos una visión coherente e innovadora de la relación entre humanidad y técnica, que coincide en muchos aspectos con las críticas y propuestas elaboradas por el mismo Simondon. Los más importantes de estos aspectos se relacionan con la idea de la extensión tecnológica de lo humano y con los grados de integración o separación existentes entre el dominio de lo técnico y el de la espiritualidad y la religión.

Records of continental slope sediment flow morphodynamic responses to gradient and active faulting from integrated AUV and ROV data, offshore Palos Verdes, southern California Borderland

Science.gov (United States)

Maier, Katherine L.; Brothers, Daniel; Paull, Charles K.; McGann, Mary; Caress, David W.; Conrad, James E.

2016-01-01

Variations in seabed gradient are widely acknowledged to influence deep-water deposition, but are often difficult to measure in sufficient detail from both modern and ancient examples. On the continental slope offshore Los Angeles, California, autonomous underwater vehicle, remotely operated vehicle, and shipboard methods were used to collect a dense grid of high-resolution multibeam bathymetry, chirp sub-bottom profiles, and targeted sediment core samples that demonstrate the influence of seafloor gradient on sediment accumulation, depositional environment, grain size of deposits, and seafloor morphology. In this setting, restraining and releasing bends along the active right-lateral Palos Verdes Fault create and maintain variations in seafloor gradient. Holocene down-slope flows appear to have been generated by slope failure, primarily on the uppermost slope (~ 100–200 m water depth). Turbidity currents created a low relief (water depositional systems. These results help to bridge gaps in scale between existing deep-sea and experimental datasets and may provide constraints for future numerical modeling studies.

Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells

International Nuclear Information System (INIS)

Dietz, Marina S; Haße, Daniel; Ferraris, Davide M; Göhler, Antonia; Niemann, Hartmut H; Heilemann, Mike

2013-01-01

The human receptor tyrosine kinase MET and its ligand hepatocyte growth factor/scatter factor are essential during embryonic development and play an important role during cancer metastasis and tissue regeneration. In addition, it was found that MET is also relevant for infectious diseases and is the target of different bacteria, amongst them Listeria monocytogenes that induces bacterial uptake through the surface protein internalin B. Binding of ligand to the MET receptor is proposed to lead to receptor dimerization. However, it is also discussed whether preformed MET dimers exist on the cell membrane. To address these issues we used single-molecule fluorescence microscopy techniques. Our photobleaching experiments show that MET exists in dimers on the membrane of cells in the absence of ligand and that the proportion of MET dimers increases significantly upon ligand binding. Our results indicate that partially preformed MET dimers may play a role in ligand binding or MET signaling. The addition of the bacterial ligand internalin B leads to an increase of MET dimers which is in agreement with the model of ligand-induced dimerization of receptor tyrosine kinases.

El Desequilibrio de lo Político en Hegel

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Juan Ignacio Arias Krause

2016-07-01

Full Text Available El problema político de la sociedad civil se fundamenta en su doble forma de manifestarse: por un lado, en ella se revela el carácter externo u objetivo del Estado y, por otro, produce una escisión al interior del mismo Estado. Tal problema que aparece como contradictorio (el ser exterior e interior a la vez es presentado en el pensamiento político de Hegel, en vistas a superar las dicotomías que en la teoría política moderna aparecían como insalvables. Esta superación Hegel la realiza mediante una interiorización de aquellos elementos que anteriormente habían sido marginados de la política, como son lo natural y el dominio privado, los que emergerían en la sociedad civil. En este artículo se exponen estos elementos en vistas a mostrar cómo es en este movimiento de interiorización y exteriorización de ellos donde se posibilita el acontecer de lo político.

MetAssimulo:Simulation of Realistic NMR Metabolic Profiles

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De Iorio Maria

2010-10-01

Full Text Available Abstract Background Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics, the study of small molecules involved in metabolic reactions, is a rapidly expanding 'omics' field. A major technique for capturing metabolite data is 1H-NMR spectroscopy and this yields highly complex profiles that require sophisticated statistical analysis methods. However, experimental data is difficult to control and expensive to obtain. Thus data simulation is a productive route to aid algorithm development. Results MetAssimulo is a MATLAB-based package that has been developed to simulate 1H-NMR spectra of complex mixtures such as metabolic profiles. Drawing data from a metabolite standard spectral database in conjunction with concentration information input by the user or constructed automatically from the Human Metabolome Database, MetAssimulo is able to create realistic metabolic profiles containing large numbers of metabolites with a range of user-defined properties. Current features include the simulation of two groups ('case' and 'control' specified by means and standard deviations of concentrations for each metabolite. The software enables addition of spectral noise with a realistic autocorrelation structure at user controllable levels. A crucial feature of the algorithm is its ability to simulate both intra- and inter-metabolite correlations, the analysis of which is fundamental to many techniques in the field. Further, MetAssimulo is able to simulate shifts in NMR peak positions that result from matrix effects such as pH differences which are often observed in metabolic NMR spectra and pose serious challenges for statistical algorithms. Conclusions No other software is currently able to simulate NMR metabolic profiles with such complexity and flexibility. This paper describes the algorithm behind MetAssimulo and demonstrates how it can be used to simulate realistic NMR metabolic profiles with

Impactos de lo global en lo local: Gentrificación en ciudades latinoamericanas

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Gabriel Gómez Carmona

2015-06-01

Full Text Available La realidad actual de nuestras ciudades implica procesos de cambio caracterizados por una recomposición de las relaciones socio-espaciales y los tradicionales patrones de convivencia y consumo. La ciudad toma un papel determinante en lo político y económico buscando su incorporación a la dinámica del mundo global; esto crea la existencia de diversas y contradictorias zonas al interior de la ciudad. El artículo analiza la renovación de las zonas centrales de dos ciudades latinoamericanas y los cambios socio-espaciales que estas ‘renovaciones’ generan pues, la evidencia muestra que la revaloración y rehabilitación de centros históricos y barrios coloniales con el fin de convertirlos en mejores lugares de tránsito, ocio y vida para sus habitantes, implican una fuerte transformación de los mismos, con realidades sociales dispares, fragmentación urbana, segregación y los consecuentes procesos de gentrificación.

David Rosenthal’s Tirant lo Blanc turns 30

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Jan Reinhart

2014-12-01

Full Text Available The groundbreaking English language translation of Tirant lo Blanc by New York poet and academic David Rosenthal remains dominant three decades after its initial, and celebrated, release. Rosenthal’s controversially fluid and concise rendering of the Valencian classic survived a serious challenge 20 years ago by a more literal version from a well-meaning amateur translator and journeyman academic backed by a leading U.S.-based Catalan scholar. The article reviews the controversy and compares the two versions, adding comments from some of the key critics. La traducció capdavantera a l’anglés del Tirant lo Blanc, feta pel poeta i erudit de Nova York, David Rosenthal, continua mantenint la seua importància, tres dècades després de publicar-se. La polèmica versió dúctil i concisa de Rosenthal del clàssic valencià, ha sobreviscut el desafiament seriós, de fa vint anys, de la versió més literal d’un benintencionat traductor amateur i acadèmci oficial, recolzat per un destacat erudit català establert als Estats Units. L’article revisa la polèmica i compara les dues versions, tot afegint els comentaris d’alguns dels crítics més importants.

Metástasis mandibular de adenocarcinoma gástrico: Presentación de un caso Mandibular metastases of gastric adenocarcinoma: A case report

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J. Ferreras Granado

2007-10-01

Full Text Available Los tumores malignos de la cavidad oral y mandíbula representan aproximadamente un 5% de todas las neoplasias malignas del cuerpo, y sólo entre el 1 y el 4% son consideradas como metástasis. Tienen su localización más frecuente a nivel de la mandíbula (80%, fundamentalmente en la región molar. Las metástasis mandibulares, cuando aparecen, suelen tener su origen en tumores primarios que asientan en la mama, pulmón, riñón, tiroides, intestinos y próstata; y con menor frecuencia en el estómago, testículos y vesícula biliar. Suelen afectar a pacientes de edad avanzada (4ª-7ª décadas de la vida sin predilección por el sexo. El tratamiento en general es paliativo y pasa por el uso de la radioterapia, quimioterapia y hormonoterapia, reservando la cirugía para casos aislados. Describimos un caso de metástasis mandibular en un paciente adulto como primera manifestación clínica de un adenocarcinoma gástrico.Malignant tumors of the mouth and jaws represents approximately 5% of all malignant neoplasms in the body, and only 1-4% are considered to be metastatic. They are most frequently located in the mandible (80%, fundamentally in the molar region. Metastases to the jaws are usually from breast, lung, kidney, thyroid gland, intestines, and prostate gland; and less frequently from stomach, testes, and bladder. They are more frequent in elderly patients (between 4th and 7th decades with no gender differences. Treatment is usually palliative and based on the use of radiotherapy, chemotherapy andhormonal therapy. Surgery is only used in selected cases. A case of mandibular metastases as first sign of malignant disease of gastric adenocarcinoma is reported.

Luuleaasta 1994 : parlamendi koosseis on selgunud / Barbi Pilvre

Index Scriptorium Estoniae

Pilvre, Barbi, 1963-

1995-01-01

Rannit, Aleksis. Nii näen sind ikka; Kangur, Kalju. Sõna sees olek; Traat, Mats. Koidu kätes; Rimmel, Rudolf. Setu netu; Suislepp, Harald. Köögertali kojutulek; Piir, Enno. Sunnitöölise Mekka; Üllaste, Leenart. Lind tormis; Hirv, Indrek. Taskuraamat (taskutähekerjus); Mirtem, Valev [Luhaäär, Ingvar]. Maithunad Eestis; Mirtem, Valev [Luhaäär, Ingvar]. Armuühtepühad; Mirtem, Valev [Luhaäär, Ingvar]. Tulevaas; Kurvits, Lembit. Matle laul; Lillemets, Enn. Olemise valge koer ehk Ingli kolju; Jessod, Mats [Jakobson, Mati]. Jah, luuletused; Jessod, Mats [Jakobson, Mati]. Ohjad Oti mäel; Jessod, Mats [Jakobson, Mati]. Poeetilisi prohmakaid; Ivar, Ivo. Riimiskid; Kilokalor, Kalle. Öösel näeb halvemini kui päeval; Trubetsky, Tõnu. Anarhia; Laanvee, Ervin. Jaa. Mina olen; Kuningas, Marko J. ...jääb USK, LOOTUS, ARMASTUS; Ruben, Arne. Ajakirjanik; Ollinovski, Jim [Ollino, Ott]. Luuletused; Toomik, Tõnu. 27 luuletust; Tosin, Ants. Õnnetähestik; Krüger, Urmas. Ka nii võib...; Kärner, Siim. Usseaid; Sikk, Heino. Võrokõstõlõ: poeem; Kollin, Viktor. Kodutunne; Alo, Ülo [Võsar, Ülo Alo]. Ööbikuvalgus; Sepp, Vello. Vigased pärlid; Palo, Wilhelm. Tuule-luuled; Soomets, Triin. Randmes unejanu; Soomets, Triin. Janu masinas; Ränik, Valeria. Ajast väljas; Kivi, Aita. Kalender-päevik Aita Kivi luuletustega; Maagemust, Maarika. Kaaludes kaldaid; Hiiussaar, Ann. Valgete uste taga; Kolkkanen, Imbi. Mina ja maailm; Mets, Neeme. Kesalill; Kolesnitshenko, Kaidi-Ly. Kaks silma; Kahro, Anne. Nälkjast!; Kabe, Aino. Tuulema mõtteriim. Raatma, Salme. Laululatern; Osila, Virve. Lootuse luiged; Isak, Asta. Valguse ja varjude vahel; Õunapuu, Meeli. Mööda teid ja radu

De la ecología de medios a la ecología profunda de medios: esclarecer la metáfora y visibilizar su impacto medioambiental

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Jesús Antonio Arroyave-Cabrera

2017-01-01

Full Text Available La ecología de medios ha generado una reflexión importante de la díada tecnología-sociedad. Sin embargo, a pesar de acuñar un concepto relacio-nado con el medio ambiente, diferentes autores han cuestionado que dicho campo multidisciplinario no haya derivado en ningún aporte importante relacionado con el contexto ambiental. Respecto de la ecología de medios, las tecnologías han causado un impacto definitivo sobre el planeta. No obs-tante, recientes tendencias en la investigación en comunicación conceptúan que este cambio trasciende lo simbólico y se instala en lo material con con-secuencias serias en los ecosistemas, en los seres vivos y en la sostenibilidad del planeta. Utilizando como base los planteamientos del filósofo norue-go Arne Naess, el presente artículo intenta contribuir a subsanar la deuda pendiente que tiene la ecología de medios con el contexto ambiental. Para propiciar esta reflexión, extendemos la metáfora de la ecología de medios a la ecología profunda de medios para a partir de este marco analizar la re-lación entre tecnologías y los aparatos/artefactos asociados a los medios y su relación con la sociedad.

Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

Energy Technology Data Exchange (ETDEWEB)

Rickert, Keith W.; Patel, Sangita B.; Allison, Timothy J.; Byrne, Noel J.; Darke, Paul L.; Ford, Rachael E.; Guerin, David J.; Hall, Dawn L.; Kornienko, Maria; Lu, Jun; Munshi, Sanjeev K.; Reid, John C.; Shipman, Jennifer M.; Stanton, Elizabeth F.; Wilson, Kevin J.; Young, Jonathon R.; Soisson, Stephen M.; Lumb, Kevin J. (Merck)

2012-03-15

The receptor tyrosine kinase c-Met is implicated in oncogenesis and is the target for several small molecule and biologic agents in clinical trials for the treatment of cancer. Binding of the hepatocyte growth factor to the cell surface receptor of c-Met induces activation via autophosphorylation of the kinase domain. Here we describe the structural basis of c-Met activation upon autophosphorylation and the selective small molecule inhibiton of autophosphorylated c-Met. MK-2461 is a potent c-Met inhibitor that is selective for the phosphorylated state of the enzyme. Compound 1 is an MK-2461 analog with a 20-fold enthalpy-driven preference for the autophosphorylated over unphosphorylated c-Met kinase domain. The crystal structure of the unbound kinase domain phosphorylated at Tyr-1234 and Tyr-1235 shows that activation loop phosphorylation leads to the ejection and disorder of the activation loop and rearrangement of helix {alpha}C and the G loop to generate a viable active site. Helix {alpha}C adopts a orientation different from that seen in activation loop mutants. The crystal structure of the complex formed by the autophosphorylated c-Met kinase domain and compound 1 reveals a significant induced fit conformational change of the G loop and ordering of the activation loop, explaining the selectivity of compound 1 for the autophosphorylated state. The results highlight the role of structural plasticity within the kinase domain in imparting the specificity of ligand binding and provide the framework for structure-guided design of activated c-Met inhibitors.

Metáforas de la eclosión y del cultivo. Imaginarios de la agricultura en época ibérica

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Olmos, Ricardo

1996-12-01

Full Text Available From a general approach various groups of Iberian images related with the signs of the vegetal world are treated in this paper: those showing an spontaneous generation and those introducing the metaphors of agriculture. We depart from a common Mediterranean thought, but our main interest will be the specificities and singularities of the Iberian examples. It is proposed to link some of these Iberian images with both the cosmogonie vision of the beginnings and the mythical invention of agriculture. In both cases images fulfill a more or less definite role within the society which demands them. The historical context could illuminate a more universal thought.Desde una lectura globalizadora analizamos varios grupos de imágenes ibéricas que se relacionan con los signos del mundo vegetal: las que muestran una generación espontánea, una eclosión, y las que introducen la metáfora del cultivo. Partimos de lo genérico mediterráneo pero buscamos lo diferencial y específico que exige cada ejemplo ibérico. Proponemos asociar estas imágenes por un lado a una visión cosmogónica —un tiempo originario—, por otro, a la invención mítica de la agricultura. En uno y otro caso las imágenes cumplen una función en mayor o menor medida definida dentro de la dialéctica social. El contexto histórico ilumina y enriquece un pensamiento más universal.

Association of Catechol-O-methyltransferase polymorphism Val158Met and mammographic density: A meta-analysis.

Science.gov (United States)

Kallionpää, Roope A; Uusitalo, Elina; Peltonen, Juha

2017-08-15

The Val158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Val158Met polymorphism on mammographic density. Original studies reporting data on mammographic density, stratified by the presence of COMT Val158Met polymorphism, were identified and combined using genetic models Met/Val vs. Val/Val, Met/Met vs. Val/Val, Val/Met+Met/Met vs. Val/Val (dominant model) and Met/Met vs. Val/Met+Val/Val (recessive model). Subgroup analyses by breast cancer status, menopausal status and use of hormone replacement therapy (HRT) were also performed. Eight studies were included in the meta-analysis. The overall effect in percent mammographic density was -1.41 (CI -2.86 to 0.05; P=0.06) in the recessive model. Exclusion of breast cancer patients increased the effect size to -1.93 (CI -3.49 to -0.37; P=0.02). The results suggested opposite effect of COMT Val158Met for postmenopausal users of HRT versus premenopausal women or postmenopausal non-users of HRT. COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects. Copyright © 2017 Elsevier B.V. All rights reserved.

«Tirant lo Blanch» i la historiografia catalana medieval

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Paül Limorti Payà

2015-09-01

Full Text Available The importance of historiography in the creation of the novel is an irrefutable fact in literature, especially in Greek inerature. Did the same happen in Catalan literature? Paül Limorti follows the traces of the historiographic genre in the making of the narrative technique of Tirant lo Blanch. Front this point of view the author analyses the creation of Diafebus as a character-narrator, which is a typical device used in the chronicies to achieve a stronger historic realism. In this sense, the author studies the manner of interrelation typical of chronicles and of Tirant lo Blanch. Another device used by Martorell to present this work as a historic recreation is the group of parallel texts (prologue and dedication which heads the book, as well as the topics which can be found in it: the false translation and the reuse of previous texts.

Betere en efficiëntere zorg met Lean Six Sigma

NARCIS (Netherlands)

Trip, A.; Jong, L.J.; Does, R.J.M.M.

2009-01-01

Zorgaanbieders moeten steeds meer met elkaar concurreren. De wetten van de markteconomie worden daarom meer en meer van toepassing in de zorgsector die dat tot voor kort helemaal niet gewend was. Dat vergt veranderingen, zowel in het besturen van deze organisaties, als in de omgang met patiënten en

Synthesis of Tc-99m labeled 1,2,3-triazole-4-yl c-met binding peptide as a potential c-met receptor kinase positive tumor imaging agent.

Science.gov (United States)

Kim, Eun-Mi; Joung, Min-Hee; Lee, Chang-Moon; Jeong, Hwan-Jeong; Lim, Seok Tae; Sohn, Myung-Hee; Kim, Dong Wook

2010-07-15

The mesenchymal-epithelial transition factor (c-Met), which is related to tumor cell growth, angiogenesis and metastases, is known to be overexpressed in several tumor types. In this study, we synthesized technetium-99m labeled 1,2,3-triazole-4-yl c-Met binding peptide (cMBP) derivatives, prepared by solid phase peptide synthesis and the 'click-to-chelate' protocol for the introduction of tricarbonyl technetium-99m, as a potential c-Met receptor kinase positive tumor imaging agent, and evaluated their in vitro c-Met binding affinity, cellular uptake, and stability. The (99m)Tc labeled cMBP derivatives ([(99m)Tc(CO)(3)]12, [(99m)Tc(CO)(3)]13, and [(99m)Tc(CO)(3)]14) were prepared in 85-90% radiochemical yields. The cold surrogate cMBP derivatives, [Re(CO)(3)]12, [Re(CO)(3)]13, and [Re(CO)(3)]14, were shown to have high binding affinities (0.13 microM, 0.06 microM, and 0.16 microM, respectively) to a purified cMet/Fc chimeric recombinant protein. In addition, the in vitro cellular uptake and inhibition studies demonstrated the high specific binding of these (99m)Tc labeled cMBP derivatives ([(99m)Tc(CO)(3)]12-14) to c-Met receptor positive U87MG cells. 2010 Elsevier Ltd. All rights reserved.

Design and Development of Multi-Transceiver Lorafi Board consisting LoRa and ESP8266-Wifi Communication Module

Science.gov (United States)

Azmi, Noraini; Sudin, Sukhairi; Munirah Kamarudin, Latifah; Zakaria, Ammar; Visvanathan, Retnam; Chew Cheik, Goh; Mamduh Syed Zakaria, Syed Muhammad; Abdullah Alfarhan, Khudhur; Badlishah Ahmad, R.

2018-03-01

The advancement of Micro-Electro-Mechanical-Systems (MEMS), microcontroller technologies and the idea of Internet of Things (IoT) motivates the development of wireless modules (e.g. WiFi, Bluetooth, Zigbee, and LoRa) that are small and affordable. This paper aims to provide detailed information on the development of the LoRaFi board. The LoRaFi 1.0 is a multi-protocol communication board developed by Centre of Excellence for Advanced Sensor Technology (CEASTech). The board was developed for but not limited to monitor the indoor air quality. The board comprises two different wireless communication modules namely, Long-range technology (LoRa) and WiFi (using ESP8266). The board can be configured to communicate either using LoRa or WiFi or both. The board has been tested and the wireless communication operates successfully. Apart from LoRa, WiFi enables data to be forwarded to the cloud/server where the data can be stored for further data analysis. This helps provide users with real-time information on their smartphones or other applications. In the future, researchers will conduct tests to investigate the communication link quality. Newer version with reduced board size and additional wireless communication module will be developed in the future as to increase board flexibility and widen the range of applications that can use the board.

Interview met Leon Deben: van tegenstellingen leer je het meeste

NARCIS (Netherlands)

van Diepen, A.; Huisman, C.

2008-01-01

Wat in de jaren zeventig begonnen is als Sociologie van bouwen en wonen is uitgegroeid tot Stadssociologie. Leon Deben heeft het medeopgebouwd. Hij nam onlangs afscheid van de universiteit met een rede over de openbare ruimte. "Het centrale bestuur van de stad is druk met de waan van de dag en dan

Mundo plural: ¿por qué los individuos hacen lo que hacen?

OpenAIRE

Lahire, Bernard

2017-01-01

En un contexto de hiper-especialización, el artículo se pregunta por una visión panorámica de la sociedad y una concepción compleja de los individuos, que no olvide a la vez la ambición teórica y el pulso empírico. Con este objetivo, se pregunta: “¿por qué los individuos hacen lo que hacen?” y propone responder con una fórmula de estudio de las prácticas de carácter universal que combina una dimensión disposicionalista con una contextualista. De un lado, las disposiciones y competencias de lo...

La renuncia del mecenas y la utopía de lo alternativo

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José Manuel Tavares de Barros

2015-01-01

Full Text Available El autor refiere lo ocurrido en el festival internacional UMBRIAFICTION TV. 92 dedicado a producciones de ficción orientadas al mercado televisivo mundial. Cita el enfrentamiento de fuerzas entre Europa y Estados Unidos en pos de ganar audiencias y mercados para sus industrias de cine y video. Relata lo que fue la llegada del neoliberalismo a Brasil con Collor de Melo donde las medidas que se tomaron en el área cultural fueron nefastas. Concluye con que hay necesidad de reivindicar socialmente el derecho de acceso a un espacio audiovisual democrático, abierto a las más legítimas aspiraciones del ser humano.

Lo evaluable del proyecto. Interrogantes desde un período de carencia.

OpenAIRE

Macagno, María Gabriela; Peralta, Sergio

2014-01-01

Documento de reflexión no derivado de investigación. Se formulan aquí -a partir del análisis de prácticas de evaluación del Taller IV de Diseño de FADU-UNL- una serie de interrogantes que buscan desplazar “lo evaluable” y “lo enseñable”, en el marco de la actual puesta en crisis y reformulación de los paradigmas de la proyectualidad y el funcionalismo. Para ello, se interroga el aprendizaje de los docentes, los criterios de evaluación y las limitaciones de la materia prima en relación co...

Esplendor y ruina de un paradigma. Lo relacional: París-Madrid, Madrid-León

OpenAIRE

Albarrán Diego, Juan

2011-01-01

[ES] El objetivo de este artículo es analizar el nacimiento de la estética relacional como propuesta teórica y paradigma institucional a partir de los escritos y programas expositivos desarrollados por Nicolas Bourriaud desde finales de los años noventa, revisando al mismo tiempo las críticas recibidas por dicho paradigma en el contexto de una problemática articulación de lo estético, lo artístico y lo político. Acto seguido, estudiaremos hasta qué punto y desde qué presupuestos se produce un...

De betekenis van Paulus' oproep tot de groet met de heilige kus

NARCIS (Netherlands)

Voogd, Joanna Bernarda

Dit boek is een studie naar de betekenis van de Paulijnse oproep tot de groet met de heilige kus. In vier passages in het Nieuwe Testament is deze oproep vindbaar: “Groet alle broeders (en zusters) met de heilige kus” (1 Tes 5:26) of “groet elkaar met de heilige kus” (1 Kor 16:20; 2 Kor 13:12 en

The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter

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Eisen Judith S

2008-07-01

Full Text Available Abstract Background Expression of correct neurotransmitters is crucial for normal nervous system function. How neurotransmitter expression is regulated is not well-understood; however, previous studies provide evidence that both environmental signals and intrinsic differentiation programs are involved. One environmental signal known to regulate neurotransmitter expression in vertebrate motoneurons is Hepatocyte growth factor, which acts through the Met receptor tyrosine kinase and also affects other aspects of motoneuron differentiation, including axonal extension. Here we test the role of Met in development of motoneurons in embryonic zebrafish. Results We found that met is expressed in all early developing, individually identified primary motoneurons and in at least some later developing secondary motoneurons. We used morpholino antisense oligonucleotides to knock down Met function and found that Met has distinct roles in primary and secondary motoneurons. Most secondary motoneurons were absent from met morpholino-injected embryos, suggesting that Met is required for their formation. We used chemical inhibitors to test several downstream pathways activated by Met and found that secondary motoneuron development may depend on the p38 and/or Akt pathways. In contrast, primary motoneurons were present in met morpholino-injected embryos. However, a significant fraction of them had truncated axons. Surprisingly, some CaPs in met morpholino antisense oligonucleotide (MO-injected embryos developed a hybrid morphology in which they had both a peripheral axon innervating muscle and an interneuron-like axon within the spinal cord. In addition, in met MO-injected embryos primary motoneurons co-expressed mRNA encoding Choline acetyltransferase, the synthetic enzyme for their normal neurotransmitter, acetylcholine, and mRNA encoding Glutamate decarboxylase 1, the synthetic enzyme for GABA, a neurotransmitter never normally found in these motoneurons, but

El puerto y la vinculación entre lo local y lo global

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Carlos Martner Peyrelongue

1999-09-01

Full Text Available Los puertos fueron espacios poco relevantes durante el periodo en que privó el modelo de desarrollo "hacia adentro" basado en la sustitución de importaciones. De allí, el desinterés por su estudio dentro de los distintos campos de las ciencias sociales, inclusive en áreas muy cercanas con esta temática, como el análisis regional y la geografía económica. Sin embargo, a raíz de la reciente reestructuración del sistema mundial capitalista, estos espacios litorales han adquirido mayor relevancia al constituirse en nodos principales de articulación de redes productivas crecientemente globalizadas. Precisamente, en este artículo se pretende hacer un análisis de las implicaciones espaciales y temporales del rol recientemente asumido por los puertos en la articulación de extensas redes de producción-distribución, las cuales redefinen los vínculos entre lo local y lo global, pero a la vez generan vastos espacios de exclusión. Aquí, los conceptos como "espacio de flujos", "territorio de redes" y " el espacio-tiempo simultáneo" de la globalización, que rescatan, desde el análisis regional y la geografía económica, la tradición estructural-sistémica desarrollada en las ciencias sociales principalmente por Braudel y Wallerstein, resultan relevantes por su fuerza explicativa en momentos de fuerte reestructuración del ámbito portuario y, en general, de la economía-mundo capitalistaPorts used to be spaces of little interest during the "inwards" development model based on imports substitution. Hence, the indifference for its study in the diverse fields of social science, even in areas too close to this topic, as regional analysis and economical geography. However, due to the recent restructure of global capitalism system, these coast line spaces have got more importance at establishing themselves as main hubs in the articulation of productive networks recently globalized. Precisely, this article intends to analyze space and

Voice: Reflections on an Artist-Led Program at the Met

Science.gov (United States)

Valladares, Maya

2017-01-01

This article explores an education project in which artist Fred Wilson, poets from Lincoln Center's Poet-Linc program, and the Met Museum Education Department collaborated to produce a teen-led spoken-word poetry performance in the Met's galleries. Wilson drew from his own knowledge of the collection to facilitate a group dialogue about objects…

La enseñanza y la educación del cuerpo infantil: Cuando el lenguaje intercede con "lo vivo"

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Cecilia Seré Quintero

2011-11-01

Full Text Available En el presente trabajo se realiza un abordaje que supone problematizar las configuraciones discursivas modernas propias del campo de la didáctica y de la pedagogía modernas en su vinculación con la dimensión corporal de la infancia. Considerar que el lenguaje opera en lo subjetivo de la infancia introduciendo una dimensión no-gobernable requiere repensar las implicancias de enseñar y educar el cuerpo en el ámbito escolar. No hay, pues, relación de exclusión entre el lenguaje, la enseñanza, la educación y el cuerpo. Enseñanza y educación son siempre instancias de palabra, indisociables de lo corporal y por lo tanto sujetas a la estructuración del lenguaje. Allí lo corporal queda indefectiblemente capturado, en tanto el cuerpo no es aquello que discurre únicamente en su dimensión imaginaria, sino que es articulado tras la contingencia propia de la inestabilidad de lo simbólico y la imposible captura de lo real. La educación del cuerpo es, entonces, el conjunto estructurado de dispositivos que no hacen más que bordear la inconsistencia de lo humano [al tiempo que la produce

Kas Eesti Mets on vanim praegu ilmuv eestikeelne ajakiri? / Rosmarii Kurvits

Index Scriptorium Estoniae

Kurvits, Roosmarii, 1969-

2015-01-01

Artiklist selgub, et vanim tänini ilmuv eestikeelne ajakiri on baptistide häälekandja Teekäija. Kuid vanuselt järgmine ongi 1921. aastast ilmuv Eesti Mets. Ühtlasi on Eesti Mets vanim kodumaine loodusajakiri

Activation of the JNK pathway is essential for transformation by the Met oncogene.

Science.gov (United States)

Rodrigues, G A; Park, M; Schlessinger, J

1997-05-15

The Met/Hepatocyte Growth Factor (HGF) receptor tyrosine kinase is oncogenically activated through a rearrangement that creates a hybrid gene Tpr-Met. The resultant chimeric p65(Tpr-Met) protein is constitutively phosphorylated on tyrosine residues in vivo and associates with a number of SH2-containing signaling molecules including the p85 subunit of PI-3 kinase and the Grb2 adaptor protein, which couples receptor tyrosine kinases to the Ras signaling pathway. Mutation of the binding site for Grb2 impairs the ability of Tpr-Met oncoprotein to transform fibroblasts, suggesting that the activation of the Ras/MAP kinase signaling pathway through Grb2 may be essential for cellular transformation. To test this hypothesis dominant-negative mutants of Grb2 with deletions of the SH3 domains were introduced into Tpr-Met transformed fibroblasts. Cells overexpressing the mutants were found to be morphologically reverted and exhibited reduced growth in soft agar. Surprisingly, the Grb2 mutants blocked activation of the JNK/SAPK but not MAP kinase activity induced by the Tpr-Met oncoprotein. Additionally, cells expressing dominant-negative Grb2 mutants had reduced PI-3-kinase activity and dominant-negative mutants of Rac1 blocked both Tpr-Met-induced transformation and activation of JNK. These experiments reveal a novel link between Met and the JNK pathway, which is essential for transformation by this oncogene.

Virginia gutierrez de pineda: ve lo que todos han visto pero piensa lo Que otros no han pensado

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Ligia Echeverri Ángel

1997-04-01

Full Text Available Este ensayo pretende hilvanar las cualidades innatas con las condiciones ambientales y educativas que afianzaron y respaldaron el surgimiento de una personalidad científica de las ciencias sociales y humanas, en una época cuando las mujeres tenían bloqueado el acceso a la formación en este campo.Por cuestión de espacio, apenas sí se menciona lo más destacado de la creación científica y literaria de Virginia Gutiérrez de Pineda, privilegiando aquellas contribuciones que han producido mayor impacto en las comunidades académicas nacional e internacional.

Otra vez hablando de lo que habla

OpenAIRE

García Calvo, Agustín

2011-01-01

Reconociendo la contradicción que se da entre la lengua DE que se habla y la lengua EN que se habla, se trata de hacer sentir al lector la inmensa complejidad de la máquina de la lengua, que nos pasa casi enteramente desapercibida. Para entender esto es preciso darse cuenta de que el artilugio de la lengua se encuentra en un nivel sub-conciente, común, que no pertenece a nadie. Hablamos así de bien gracias a que no nos damos cuenta de lo que hacemos cuando hablamos. Esto se ilustra negativame...

PRIMEROS ANTECEDENTES SOBRE LO INFINITAMENTE PEQUEÑO

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Iván Castro Chadid

2004-06-01

Full Text Available El concepto matemático de lo infinitamente pequeño fue fruto de un arduo trabajo de la humanidad a través de muchos siglos, los primeros logros al respecto se deben fundamentalmente a los desarrollos obtenidos por los atomistas cuyos principales exponentes fueron Demócrito, Zenón, Arquímedes en la antigua Grecia y Galileo, Cavalieri en el Renacimiento. En este artículo se hace una presentación de los métodos empleados por Arquímedes y Cavalieri para abordar este problema desde su propia perspectiva.

Intern transport beter te plannen met computer

NARCIS (Netherlands)

Annevelink, E.

1999-01-01

Verbetering van intern transport in de potplantenteelt. Door getoetste vuistregels te combineren met toegepaste wiskunde is automatische planning van het intern transport binnen handbereik. Dit leidt tot minder transportbewegingen en tijdsbesparing bij het plannen

In vivo detection of c-Met expression in a rat C6 glioma model.

Science.gov (United States)

Towner, R A; Smith, N; Doblas, S; Tesiram, Y; Garteiser, P; Saunders, D; Cranford, R; Silasi-Mansat, R; Herlea, O; Ivanciu, L; Wu, D; Lupu, F

2008-01-01

The tyrosine kinase receptor, c-Met, and its substrate, the hepatocyte growth factor (HGF), are implicated in the malignant progression of glioblastomas. In vivo detection of c-Met expression may be helpful in the diagnosis of malignant tumours. The C6 rat glioma model is a widely used intracranial brain tumour model used to study gliomas experimentally. We used a magnetic resonance imaging (MRI) molecular targeting agent to specifically tag the cell surface receptor, c-Met, with an anti-c-Met antibody (Ab) linked to biotinylated Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-albumin in rat gliomas to detect overexpression of this antigen in vivo. The anti-c-Met probe (anti-c-Met-Gd-DTPA-albumin) was administered intravenously, and as determined by an increase in MRI signal intensity and a corresponding decrease in regional T(1) relaxation values, this probe was found to detect increased expression of c-Met protein levels in C6 gliomas. In addition, specificity for the binding of the anti-c-Met contrast agent was determined by using fluorescence microscopic imaging of the biotinylated portion of the targeting agent within neoplastic and 'normal'brain tissues following in vivo administration of the anti-c-Met probe. Controls with no Ab or with a normal rat IgG attached to the contrast agent component indicated no non-specific binding to glioma tissue. This is the first successful visualization of in vivo overexpression of c-Met in gliomas.

Lo social, lo comunitario y lo individual en las estrategias de prevención “social” del delito en Argentina (2003-2008 (“Social”, “community” and “individual” in social crime prevention strategies in Argentina (2003-2008

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Emilio J. Ayos

2012-07-01

Full Text Available El artículo aborda las construcciones de lo individual, lo comunitario y lo social que emergen en la confluencia de una intervención de prevención “social” del delito y una política social asistencial en Argentina. Es producto de una investigación mayor que se propone indagar acerca de la relación entre las definiciones de pobreza y delito y las estrategias de intervención asociadas a las mismas en la articulación entre los programas Comunidades Vulnerables y de Empleo Comunitario. Desde un enfoque metodológico cualitativo, se argumentará que la implementación de dicha estrategia de prevención social del delito, en su vinculación con una política asistencial, describirá una tendencia hacia la comunitarización de su intervención a partir de construir una territorialización segmentada, y hacia la individualización, fundamentalmente en los mecanismos preventivos propuestos.ABSTRACTThis article focuses at the analysis of the tensions that emerge from the meeting of a social crime prevention strategy and a social policy in Argentina. These tensions turn run the constructions of the idea of “social”, “community” and “individual”. This analysis is part of a bigger research which has as a general objective the exploration of the association between the definitions of “poverty” and “crime” and the intervention strategies that emerge from that intersection, specifically in the articulation between two programs: “Vulnerable Communities” and “Community Employment”. Using a qualitative methodology, it will be argued that the implementation of such crime social prevention strategy, in its association with a welfare policy, would describe a trend characterized by the communitisation, from building a segmented territorialization, and the individualization, mainly in the preventive mechanisms proposed, of the strategy itself.