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Sample records for ottobre 8-9 9-10

  1. 2-tert-Butyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole

    Directory of Open Access Journals (Sweden)

    Janina Wobbe

    2011-09-01

    Full Text Available 2-tert-Butyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole was synthesized by reaction of cycloheptanone and (4-tert-butylphenylhydrazine hydrochloride in the presence of sodium acetate and sulfuric acid in glacial acetic acid via Fischer indole synthesis.

  2. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    Science.gov (United States)

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  3. In situ crystallization of the linear alkynes CnH2n–2 (n = 7, 8, 9, 10)

    DEFF Research Database (Denmark)

    Bond, Andrew; Davies, John E

    2014-01-01

    A manual in situ crystallization technique is described, for application on a κ-geometry area-detector instrument. The technique has been applied to grow crystals of some linear alkynes: 1-heptyne, 1-octyne, 1-nonyne and 1-decyne, Cn H2n–2 (n=7, 8, 9, 10). The structures with odd n (1-heptyne and 1...... 5.7×7.2 Å, identical to the layers present in the previously published structures of 1,7-octadiyne and 1,9-decadiyne. The structures differ where the methyl groups meet, giving systematically greater packing efficiency for 1-heptyne and 1-nonyne, compared to 1-octyne and 1-decyne. This systematic...

  4. Tannic Acid an Efficient Catalyst for the Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one Derivatives

    Directory of Open Access Journals (Sweden)

    Deepak S. Kawade

    2015-06-01

    Full Text Available Tannic acid explore a highly efficient catalytic activity for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives in excellent yields via cyclocondensation of aromatic aldehyde, β-naphthol and dimedone. Catalyst having advantages such as it is cheap and biodegradable and the protocol avoids the use of expensive catalyst and toxic solvent. We believe that this methodology is an efficient, simple, highly yielding, time saving and environmentally friendly. DOI: http://dx.doi.org/10.17807/orbital.v7i2.683

  5. An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist

    DEFF Research Database (Denmark)

    Isherwood, Matthew; Guzzo, Peter R.; Henderson, Alan J.

    2012-01-01

    precipitation from n-hexane. The absolute stereochemistry of 7a was determined by X-ray crystallography and the structure was confirmed as (7S,10R)-tert-butyl 2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate. Removal of the chiral auxiliary under basic conditions afforded...

  6. Diels-Alder Reactions of 12-Hydroxy-9(10®20-5aH-abeo-abieta-1(10,8(9,12(13-triene-11,14-dione

    Directory of Open Access Journals (Sweden)

    Shougang Hu

    2013-06-01

    Full Text Available 12-Hydroxy-9(10®20-5aH-abeo-abieta-1(10,8(9,12(13-triene-11,14-dione (quinone 2 served as the dienophile in numerous intermolecular Diels-Alder reactions. These cycloadditions were conducted either thermally (including microwave heating or with Lewis acid activation. While most dienes reacted with quinone 2 in good chemical yield, others were incompatible under the experimental conditions used.

  7. Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol; putative structure of a conjugated diyne natural product isolated from Hydrocotyle leucocephala.

    Science.gov (United States)

    Prasad, Kavirayani R; Swain, Bandita

    2011-04-01

    Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol, a structure proposed for the natural product isolated from Hydrocotyle leucocephala is accomplished. The reported spectral data of the natural product did not match those of any of the isomers that were synthesized and established that the structure proposed for the natural product is not correct and requires revision.

  8. Binding of benzo(a)pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9, 10-tetrahydrobenzo(a)pyrene to histones

    International Nuclear Information System (INIS)

    Sculley, T.B.; Zytkovicz, T.H.

    1983-01-01

    AKR-2B mouse embryo cells were incubated for 24 hr with [3H]benzo(a)pyrene, and the histones were isolated and analyzed using one- and two-dimensional gel electrophoresis and autoradiography. The results revealed that (a) histones H1, H2A, and H3 incorporated significant amounts of label whereas little or no label was associated with histones H2B and H4 and (b) electrophoresis of the histones in the Triton: acid: urea gel system caused labeled histones to have a slower migration than did the corresponding unlabeled histones. Additional studies such as incubation of (+/-)-7 beta,8 alpha-[3H]dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with nuclei resulted in radioactive labeling of histones H1, H2A, H2B, and H3 and of high-mobility-group proteins HMG1 and HMG2. The low levels of label associated with histone H4 in the whole-cell and nuclear studies were further investigated by incubating isolated histones with (+/-)-7 beta,8 alpha-[3H]dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Under these conditions, negligible amounts of radioactivity were associated with H4, while significant labeling of H1, H2A, H2B, and H3 and other nuclear proteins was observed. The results suggest that factors other than the presence of suitable nucleophilic acceptor sites on the histones may be necessary for carcinogen binding

  9. Translation of satellite tobacco necrosis virus RNA modified by (not equal to)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene is inhibited in a wheat germ cell-free system

    International Nuclear Information System (INIS)

    Haas, R.; Pulkrabek, P.; Takanami, Y.; Grunberger, D.

    1983-01-01

    It has been shown that (not equal to)-r-7-,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) modification of rabbit globin mRNA results in inhibition of translational initiation. In order to explore the possibility that modification of the 5' cap structure was responsible for this inhibition, the naturally non-capped mRNA from satellite tobacco necrosis virus (STNV) was reacted with BPDE and translated in a wheat germ cell-free system. The extent of modification was 1.3 and 2.9 BPDE residues/molecule. High performance liquid chromatography of the modified nucleosides from enzymatically hydrolyzed STNV RNA revealed that greater than 90% of the nucleoside adducts were substituted at the exocyclic amino group of guanosine. The translational ability of the lower and higher modified STNV, measured by incorporation of [ 14 C]amino acids into acid-precipitable polypeptides is inhibited by 55% and 63%, respectively. Polyacrylamide gel electrophoretic analyses of the translation products indicate that predominantly full-length coat proteins are synthesized but with the carcinogen-modified STNV the amount is reduced. On the other hand, 80S initiation complex formation is not inhibited as measured by binding of the BPDE-modified STNV to ribosomes and followed by glycerol gradient centrifugation. Under these conditions, aurintricarboxylic acid completely inhibits 80S initiation complex formation in the presence of either modified or native STNV. These results suggest that inhibition of in vitro translation of BPDE-modified STNV, in contrast to that of globin mRNA, is not at the level of initiation complex formation but possibly by premature termination of growing polypeptides

  10. Il viaggio necessario: l'ottobre caldo della tragedia lampedusana

    Directory of Open Access Journals (Sweden)

    Samantha Viva

    2015-07-01

    Full Text Available Era ottobre. L’ottobre caldo e triste della tragedia lampedusana, del lutto e delle parole. L’ottobre dei 366 cadaveri dei migranti di origine eritrea e dei 150, tra uomini e donne, recuperati e salvati. Non era ancora scoppiato il caso al Centro di Primo Soccorso di Contrada Imbriacola, non era ancora stato chiuso per le docce della vergogna, per i trattamenti da lager con cui i dipendenti della Cooperativa che gestiva il Centro di Primo Soccorso, si prendevano cura dei migranti. Io ero andata lì a vedere cosa restava di quelle vite, e di quelli che continuavano ad arrivare, anche dopo.

  11. Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride.

    Science.gov (United States)

    Struga, Marta; Kossakowski, Jerzy; Stefańska, Joanna; Zimniak, Andrzej; Koziol, Anna E

    2008-06-01

    A new quaternary ammonium compound, bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride (4), was synthesized. The compound was investigated for antibacterial activity, including Gram-positive cocci and Gram-negative rods, and antifungal activity. Compound 4 showed significant inhibition against Staphylococcus aureus. Research was carried out over 4 standard strains and 40 hospital strains. Elementary analysis and/or MS, (1)H NMR and (13)C NMR spectra confirmed the identity of the products. The molecular structure of 3 was determined by an X-ray analysis.

  12. Eleonora Duse interpreta Gor'kij (Parigi-Milano, ottobre 1905

    Directory of Open Access Journals (Sweden)

    Maria Pia Pagani

    2013-06-01

    Full Text Available Questo contributo porta alla luce alcuni problemi relativi a traduzione e allestimento de I bassifondi (L’albergo dei poveri di Maksim Gor’kij – l’unico dramma russo che Eleonora Duse riuscì a includere nel suo repertorio. La grande attrice lo portò in scena due volte, a distanza di pochi giorni, al Théâtre de l’Oeuvre di Parigi con la compagnia di Aurelien Lugné-Poe (23 ottobre 1905, e al Teatro Manzoni di Milano con la compagnia Talli-Gramatica-Calabresi (28 ottobre 1905. Il critico Gaio (pseudonimo di Adolfo Orvieto assistette a entrambe le rappresentazioni e scrisse un’attenta recensione per «Il Marzocco» evidenziandone le differenze.

  13. Latin America: A Cultural Region of the World; An Instructional Unit for Grades 8, 9, 10.

    Science.gov (United States)

    Gill, Clark C.; Conroy, William B.

    This teaching package or unit is part of a sequence of materials developed by the Latin American Curriculum Project. Concepts, key ideas and facts introduced in earlier grades on socio-cultural patterns are reinforced by this multidisciplinary approach. The major topic emphasis is the history of the periods since the beginning of the Independence…

  14. A Simple and Efficient Synthesis of 12-Aryl-8,9,10,12 ...

    African Journals Online (AJOL)

    Highly effective zinc oxide nanoparticles catalyzed solvent-free synthesis of some tetrahydrobenzo[a]xanthen-11-one derivatives via one-pot multi-component reaction of aldehydes, 2-naphthol and dimedone. The present approach creates a variety of biologically active heterocyclic compounds in excellent yields and short ...

  15. Learning Activity Package, Physical Science. LAP Numbers 8, 9, 10, and 11.

    Science.gov (United States)

    Williams, G. J.

    These four units of the Learning Activity Packages (LAPs) for individualized instruction in physical science cover nuclear reactions, alpha and beta particles, atomic radiation, medical use of nuclear energy, fission, fusion, simple machines, Newton's laws of motion, electricity, currents, electromagnetism, Oersted's experiment, sound, light,…

  16. Home Economics Education. Course of Study for Occupationally Oriented Classes. Grades 8, 9, 10.

    Science.gov (United States)

    Fairfax County Schools, VA.

    GRADES OR AGES: Grades 8-10. SUBJECT MATTER: Vocational home economics. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into three sections, one for each grade. Sections are further subdivided into units, each of which is laid out in three columns. Column headings are goals and concepts, activities and resources and notes. The guide is…

  17. Stochastic Processes and their Applications Conference, (32nd), held in Champaign, Illinois, August 6, 7, 8, 9, 10, 2007

    Science.gov (United States)

    2007-08-01

    Preliminary results show that Pedro Mendez, Mathematics, Universidad Wiener white and colored and Levy white noises all have • de Costa Rica the effect of...Systems - O’ ( (’ on a Stochastic Shell Model Joaquin Fontbona, Mathematical S1.) .>, 11 Engineering, University of Chile5 9 0 Hakima Bessaih

  18. Crystal structure of 7,8,9,10-tetrahydrobenzo[b]naphtho[2,1-d]furan

    Directory of Open Access Journals (Sweden)

    Zhongyuan Wu

    2016-01-01

    Full Text Available In the title compound, C16H14O, the cyclohexene ring has a half-chair conformation. The mean plane, calculated through all non-H atoms of the molecule, except for the central CH2 atoms of the cyclohexene ring, which deviate by 0.340 (3 and −0.369 (3 Å from this mean plane, has an r.m.s. deviation of 0.012 Å. In the crystal, there are C—H...π contacts present, resulting in the formation of zigzag chains propagating along the [010] direction.

  19. 46 CFR 9.10 - Waiting time.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Waiting time. 9.10 Section 9.10 Shipping COAST GUARD... § 9.10 Waiting time. The same construction should be given the act when charging for waiting time as... for duty the waiting time amounts to at least one hour. ...

  20. 1 CFR 8.9 - Form of citation.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form of citation. 8.9 Section 8.9 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.9 Form of citation. The Code of Federal Regulations may be cited by title and...

  1. 49 CFR 8.9 - Information Security Review Committee.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review Committee...

  2. Aerial radiological survey of Areas 1, 2, 3, 4, 6, 7, 8, 9, 10, 12, 15 and 17, Yucca Flat, Nevada Test Site, 8 August-2 September 1978

    International Nuclear Information System (INIS)

    Fritzsche, A.E.

    1982-06-01

    An aerial gamma survey was conducted over Yucca Flat during August 1978. A limited quantity of soil samples was obtained and evaluated in support of the aerial survey. Results are presented in the form of exposure rate isopleths from man-made isotopes and estimates of concentrations and inventories of 152 Eu, 137 Cs and 60 Co

  3. FINAL INTERIM REPORT VERIFICATION SURVEY ACTIVITIES IN FINAL STATUS SURVEY UNITS 7, 8, 9, 10, 11, 13 and 14 AT THE SEPARATIONS PROCESS RESEARCH UNIT, NISKAYUNA, NEW YORK

    International Nuclear Information System (INIS)

    Jadick, M.G.

    2010-01-01

    The Separations Process Research Unit (SPRU) facilities were constructed in the late 1940s to research the chemical separation of plutonium and uranium. SPRU operated between February 1950 and October 1953. The research activities ceased following the successful development of the reduction/oxidation and plutonium/uranium extraction processes that were subsequently used by the Hanford and the Savannah River sites.

  4. 11-[Bis(trimethylsilylamino]-2,4-bis(trimethylsilyl-7,8,9,10-tetrahydro-6H-cyclohepta[1,2-b]quinoline

    Directory of Open Access Journals (Sweden)

    Ísmail Çelik

    2017-06-01

    Full Text Available In the title compound, C26H48N2Si4, the cycloheptane ring adopts a chair conformation, while the quinolinyl ring system is almost planar [maximum deviation = 0.040 (3 Å for one of the C atoms carrying a Me3Si group]. In the crystal, in the absence of classical hydrogen bonding, the packing is dominated by van der Waals forces. One of the N-bound trimethylsilyl groups is disordered by rotation about the C—SiMe3 bond, and was modelled over two sets of sites in the ratio 0.873 (8:0.127 (8.

  5. Manuscript 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 ...

    Indian Academy of Sciences (India)

    58

    family of U(n)-invariant extremal Kähler metrics in symplectic action-angle coor- dinates. Tφnnesen-Friedman [4, 5, 6] used the hamiltonian construction to get new extremal metrics on some P1 -bundles over products of Kähler-Einstein manifolds of negative scalar curvature and other important results. For more references ...

  6. Manuscript 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 ...

    Indian Academy of Sciences (India)

    11

    Then Sσ = σ∨ ∩ N∨ is commutative semigroup and Uσ = Spec k[Sσ] is an affine toric variety. For a general toric variety X of dimension n, there. 1Following [6, Definition, p162], we use P(E) to denote the associated projective space bundle i.e. ProjX Sym E for a locally free sheaf E on a scheme X. 1. Manuscript. 1. 2. 3. 4. 5.

  7. 22 CFR 9.10 - Mandatory declassification review.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mandatory declassification review. 9.10 Section 9.10 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.10 Mandatory declassification review. All requests to the Department by a member of the public, a government employee, or an...

  8. Epigenetics Europe conference. Munich, Germany, 8-9 September 2011.

    Science.gov (United States)

    Jeltsch, Albert

    2011-12-01

    At the Epigenetics Europe conference in Munich, Germany, held on 8-9 September 2011, 19 speakers from different European countries were presenting novel data and concepts on molecular epigenetics. The talks were mainly focused on questions of the generation, maintenance, flexibility and erasure of DNA methylation patterns in context of other epigenetic signals like histone tail modifications and ncRNAs.

  9. Isotypic crystal structures of 1-benzyl-4-(4-bromophenyl-2-imino-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile and 1-benzyl-4-(4-fluorophenyl-2-imino-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile

    Directory of Open Access Journals (Sweden)

    R. A. Nagalakshmi

    2014-11-01

    Full Text Available The molecules of the two isotypic title compounds, C25H24BrN3, (I, and C25H24FN3, (II, comprise a 2-iminopyridine ring fused with a cyclooctane ring. In (I, the cyclooctane ring adopts a twisted chair–chair conformation, while in (II, this ring adopts a twisted boat–chair conformation. The dihedral angles between the planes of the pyridine ring and the bromobenzene and phenyl rings are 80.14 (12 and 71.72 (13°, respectively, in (I. The equivalent angles in (II are 75.25 (8 and 68.34 (9°, respectively. In both crystals, inversion dimers linked by pairs of C—H...N interactions generate R22(14 loops, which are further connected by weak C—H...π interactions, generating (110 sheets.

  10. A new 9,10-dihydrophenanthrene from Dendrobium moniliforme.

    Science.gov (United States)

    Zhao, Ningdong; Yang, Guangyu; Zhang, Yan; Chen, Lijun; Chen, Yegao

    2016-01-01

    A new 9,10-dihydrophenanthrene,1,5-dihydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthrene (1) was isolated and identified from the whole plants of Dendrobium moniliforme, as well as 24 known compounds including hircinol (2), (2R*,3S*)-3-hydroxymethyl-9-methoxy-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-2,3,6,7-tetrahydro-phenanthro[4,3-b]furan-5,11-diol (3), diospyrosin (4), aloifol I (5), moscatilin (6), 3,4'-dihydroxy-3',4,5-trimethoxybibenzyl (7), gigantol (8), 3,3'-dihydroxy-4,5-dimethoxybibenzyl (9), longicornuol A (10), N-trans-cinnamoyltyramine (11), paprazine (12), N-trans-feruloyl 3'-O-methyldopamine (13), moupinamide (14), dihydroconiferyl dihydro-p-coumarate (15), dihydrosinapyl dihydro-p-coumarate (16), 3-isopropyl-5-acetoxycyclohexene-2-one-1 (17), p-hydroxybenzaldehyde (18), vanillin (19), p-hydroxyphenylpropionic acid (20), vanillic acid (21), protocatechuic acid (22), (+)-syringaresinol (23), β-sitosterol (24) and daucosterol (25). Compounds 3, 4, 13, 16, 17 and 20 were isolated from the Dendrobium genus for the first time, and compounds 2, 5, 7, 9-12, 14, 15, 18, 21 and 22 were originally obtained from D. moniliforme.

  11. 7 CFR 319.8-9 - Hull fiber and gin trash.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Hull fiber and gin trash. 319.8-9 Section 319.8-9 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION... Importation and Entry of Cotton and Covers § 319.8-9 Hull fiber and gin trash. (a) Entry of hull fiber will be...

  12. 40 CFR 8.9 - Measures to assess and verify environmental impacts.

    Science.gov (United States)

    2010-07-01

    ... environmental impacts. 8.9 Section 8.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.9 Measures to assess and verify environmental impacts. (a) The operator shall conduct appropriate monitoring of key environmental indicators as...

  13. Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry.

    Science.gov (United States)

    Jeffrey, A M; Grzeskowiak, K; Weinstein, I B; Nakanishi, K; Roller, P; Harvey, R G

    1979-12-14

    The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.

  14. Spectroscopical analysis and molecular mechanics calculation of 8,9-Seco-lanostane; Analise espectroscopica e calculos de mecanica molecular de 8,9-seco-lanostanos

    Energy Technology Data Exchange (ETDEWEB)

    Rehder, Vera G; Fujiwara, Fred Y; Marsaioli, Anita J [Universidade Estadual de Campinas, SP (Brazil). Inst. de Quimica

    1992-12-31

    8.9-Seco-lanostane derivatives have been synthesized visualizing their application as intermediates in chiral building block syntheses and we are here presenting their spectroscopy analyses and MM2 molecular mechanic calculations. (author) 5 refs., 4 figs.

  15. Reaction of a chemotherapeutic agent, 6-mercaptopurine, with a direct-acting, electrophilic carcinogen, benzo[a]pyrene-7,8-diol 9,10-epoxide.

    Science.gov (United States)

    MacLeod, M C; Stewart, E; Daylong, A; Lew, L K; Evans, F E

    1991-01-01

    The chemotherapeutic agent 6-mercaptopurine (6-MP) has been shown to react covalently with the ultimate carcinogenic metabolite of benzo[a]pyrene, 7-r,8-t-dihydroxy-9-t,10-t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), in aqueous solution, forming a single adduct. NMR studies of the HPLC-purified product were consistent with its identification as 10(S)-(6'-mercaptopurinyl)-7,8,9-trihydroxy-7,8,9,10- tetrahydrobenzo[a]pyrene. Reaction kinetics were analyzed by using both HPLC separation of the products formed and a spectrophotometric assay for adduct formation. A simple model in which direct reaction between 6-MP and BPDE takes place without formation of a physical complex was found to adequately predict the dependence of product ratios on 6-MP concentration. Variations in the observed rate constant for this reaction with changes in temperature, pH, and buffer concentration were determined and compared to the effects of these variables on the observed rate constant for BPDE hydrolysis. In each case, the processes were affected quite differently, suggesting that different rate-determining steps are involved. The data suggest that the reaction mechanism involves SN2 attack of the anion of 6-MP, formed by ionization of the sulfhydryl group, on carbon 10 of BPDE, resulting in a trans-9,10 reaction product.

  16. Ohio’s Research Initiative for Locals Peer Exchange Report, March 8-9, 2017

    Science.gov (United States)

    2017-10-23

    On March 8-9, 2017, the Ohio Department of Transportation (ODOT) hosted a peer exchange on behalf of the Ohios Research Initiative for Locals (ORIL) program. Peer exchanges provide an opportunity to foster best practices and evaluate processes wit...

  17. One-electron reduction of 9,10-anthraquinone, 1-amino-9,10-anthraquinone and 1-hydroxy-9,10-anthraquinone in aqueous-isopropanol-acetone mixed solvent: a pulse radiolysis study

    International Nuclear Information System (INIS)

    Pal, H.; Mukherjee, T.; Mittal, J.P.

    1994-01-01

    The semiquinone radicals produced by one-electron reduction of 9,10-anthraquinone, 1-amino- 9,10-anthraquinone and 1-hydroxy-9,10-anthraquinone have been characterized in aqueous-organic mixed solvent comprising of 30.2 mol dm -3 water, 5 mol dm -3 isopropanol and 1 mol dm -3 acetone, using the pulse radiolysis technique. Spectroscopic characteristics, the kinetic parameters of formation and decay and one acid dissociation constants of the semiquinones and one-electron reduction potentials of the quinones have been estimated. The characteristics of the present semiquinone systems have been compared with those of other similar systems. The observed differences in characteristics of the semiquinones due to different substitutions have been analysed. (Author)

  18. EFFECTS OF A HEAVY-ATOM SALT ON THE SOLID-MATRIX LUMINESCENCE PROPERTIES OF TRANS-7,8-DIHYDROXY-ANTI-9,10-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE-DNA ADDUCTS AND TETROL I-1 ADSORBED ON SEVERAL SOLID MATRICES. (R824100)

    Science.gov (United States)

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  19. Nuclear charge radii of 8,9Li determined by laser spectroscopy

    International Nuclear Information System (INIS)

    Ewald, G.; Dax, A.; Goette, S.; Kirchner, R.; Kluge, H.J.; Kuehl, T.; Sanchez, R.; Wojtaszek, A.; Noertershaeuser, W.; Drake, G.W.F.; Yan, Z.C.; Zimmermann, C.

    2004-06-01

    The 2S → 3S transition of 6,7,8,9 Li was studied by high-resolution laser spectroscopy using two-photon Doppler-free excitation and resonance-ionization detection. The hyperfine structure splitting and the isotope shift were determined with precision at the 100 kHz level. Combined with recent theoretical work, the changes in nuclear charge radii of 8,9 Li were determined. These are now the lightest short-lived isotopes for which the charge radii have been measured. It is found that the charge radii monotonically decrease with increasing neutron number from 6 Li to 9 Li. (orig.)

  20. Space, time and group identity in Jubilees 8-9 | Venter | HTS ...

    African Journals Online (AJOL)

    Jubilees 8-9 is a rewriting of Genesis 10. It changed a depiction of Israel's identity in genealogical terms into one using spatial terms. This ideological construct was based on a Noah tradition and on Biblical texts describing the ideal borders of the land allotted to. Israel. Using a triad of space, time and identity the author of ...

  1. Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

    CERN Multimedia

    Patrice Loiez

    2003-01-01

    Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  2. 7 CFR 8.9 - Use in 4-H fund raising.

    Science.gov (United States)

    2010-01-01

    ... Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.9 Use in 4-H fund raising. (a) Fund-raising programs using the 4-H Name or Emblem may be carried out for specific educational purposes. Such fund-raising programs and use of the 4-H name and emblem on, or associated with, products, and services...

  3. File list: Pol.Emb.10.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.10.AllAg.Mitotic_cycle_8-9 dm3 RNA polymerase Embryo Mitotic cycle 8-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.10.AllAg.Mitotic_cycle_8-9.bed ...

  4. File list: ALL.Emb.05.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Emb.05.AllAg.Mitotic_cycle_8-9 dm3 All antigens Embryo Mitotic cycle 8-9 SRX084...383 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Emb.05.AllAg.Mitotic_cycle_8-9.bed ...

  5. File list: InP.Emb.20.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Emb.20.AllAg.Mitotic_cycle_8-9 dm3 Input control Embryo Mitotic cycle 8-9 http:...//dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Emb.20.AllAg.Mitotic_cycle_8-9.bed ...

  6. File list: InP.Emb.50.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Emb.50.AllAg.Mitotic_cycle_8-9 dm3 Input control Embryo Mitotic cycle 8-9 http:...//dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Emb.50.AllAg.Mitotic_cycle_8-9.bed ...

  7. File list: ALL.Emb.20.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Emb.20.AllAg.Mitotic_cycle_8-9 dm3 All antigens Embryo Mitotic cycle 8-9 SRX084...383 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Emb.20.AllAg.Mitotic_cycle_8-9.bed ...

  8. File list: Pol.Emb.20.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.20.AllAg.Mitotic_cycle_8-9 dm3 RNA polymerase Embryo Mitotic cycle 8-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.20.AllAg.Mitotic_cycle_8-9.bed ...

  9. File list: Pol.Emb.50.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.50.AllAg.Mitotic_cycle_8-9 dm3 RNA polymerase Embryo Mitotic cycle 8-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.50.AllAg.Mitotic_cycle_8-9.bed ...

  10. File list: Oth.Emb.10.AllAg.Mitotic_cycle_8-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Emb.10.AllAg.Mitotic_cycle_8-9 dm3 TFs and others Embryo Mitotic cycle 8-9 SRX0...84383 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Emb.10.AllAg.Mitotic_cycle_8-9.bed ...

  11. 12 CFR 9.10 - Fiduciary funds awaiting investment or distribution.

    Science.gov (United States)

    2010-01-01

    ... distribution. 9.10 Section 9.10 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY... has investment discretion, the bank shall obtain for funds awaiting investment or distribution a rate... principal and interest; (ii) Securities that qualify as eligible for investment by national banks pursuant...

  12. Vibrational assignments for the Raman and the phosphorescence spectra of 9,10-anthraquinone and 9,10-anthraquinone-d81

    International Nuclear Information System (INIS)

    Lehmann, K.K.; Smolarek, J.; Khalil, O.S.; Goodman, L.

    1979-01-01

    The Raman spectra of 9,10-anthraquinone (AQ) and 9,10-anthraquinone-d/sub 8/ are examined. Raman band assignments are made from this data and from a published normal coordinate analysis. The Raman spectra of AQ at 5K is reported and vibrational assignments for the phosphorescence spectra of AQ in n-hexane at 4.2 K are reexamined in light of new 3 B 1 /sub g/ → 1 A/sub g/ phosphorescence data. Contrary to previous work from this laboratory, it is concluded that although higher order vibronic interactions may be operative between the two closely spaced 3 A/sub u/- 3 B 1 /sub g/ electronic states, these interactions are not manifested in the phosphorescence spectra of AQ in n-hexane at 4.2 K

  13. Highly twisted 1,2:8,9-dibenzozethrenes: Synthesis, ground state, and physical properties

    KAUST Repository

    Sun, Zhe; Zheng, Bin; Hu, Pan; Huang, Kuo-Wei; Wu, Jishan

    2014-01-01

    Two soluble and stable 1,2:8,9-dibenzozethrene derivatives (3a,b) are synthesized through a palladium-catalyzed cyclodimerization reaction. X-ray crystallographic analysis shows that these molecules are highly twisted owing to congestion at the cove region. Broken-symmetry DFT calculations predict that they have a singlet biradical ground state with a smaller biradical character and a large singlet-triplet energy gap; these predictions are supported by NMR and electronic absorption measurements. They have small energy gaps and exhibit farred/near-infrared absorption/emission and amphoteric redox behaviors.

  14. Discovery of rare, diagnostic AluYb8/9 elements in diverse human populations.

    Science.gov (United States)

    Feusier, Julie; Witherspoon, David J; Scott Watkins, W; Goubert, Clément; Sasani, Thomas A; Jorde, Lynn B

    2017-01-01

    Polymorphic human Alu elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential to discover Alu elements in human populations, and various sequencing and bioinformatics methods have been designed to tackle the problem of detecting these highly repetitive elements. However, current techniques for Alu discovery may miss rare, polymorphic Alu elements. Combining multiple discovery approaches may provide a better profile of the polymorphic Alu mobilome. Alu Yb8/9 elements have been a focus of our recent studies as they are young subfamilies (~2.3 million years old) that contribute ~30% of recent polymorphic Alu retrotransposition events. Here, we update our ME-Scan methods for detecting Alu elements and apply these methods to discover new insertions in a large set of individuals with diverse ancestral backgrounds. We identified 5,288 putative Alu insertion events, including several hundred novel Alu Yb8/9 elements from 213 individuals from 18 diverse human populations. Hundreds of these loci were specific to continental populations, and 23 non-reference population-specific loci were validated by PCR. We provide high-quality sequence information for 68 rare Alu Yb8/9 elements, of which 11 have hallmarks of an active source element. Our subfamily distribution of rare Alu Yb8/9 elements is consistent with previous datasets, and may be representative of rare loci. We also find that while ME-Scan and low-coverage, whole-genome sequencing (WGS) detect different Alu elements in 41 1000 Genomes individuals, the two methods yield similar population structure results. Current in-silico methods for Alu discovery may miss rare, polymorphic Alu elements. Therefore, using multiple techniques can provide a more accurate profile of Alu elements in individuals and populations. We improved our false-negative rate as an indicator of sample quality for future

  15. Highly twisted 1,2:8,9-dibenzozethrenes: Synthesis, ground state, and physical properties

    KAUST Repository

    Sun, Zhe

    2014-08-08

    Two soluble and stable 1,2:8,9-dibenzozethrene derivatives (3a,b) are synthesized through a palladium-catalyzed cyclodimerization reaction. X-ray crystallographic analysis shows that these molecules are highly twisted owing to congestion at the cove region. Broken-symmetry DFT calculations predict that they have a singlet biradical ground state with a smaller biradical character and a large singlet-triplet energy gap; these predictions are supported by NMR and electronic absorption measurements. They have small energy gaps and exhibit farred/near-infrared absorption/emission and amphoteric redox behaviors.

  16. `elyon as hypostasis of Ahura Mazda – a reading of Dt 32.8-9

    Directory of Open Access Journals (Sweden)

    Osvaldo Luiz Ribeiro

    2016-12-01

    Full Text Available The paper postulates the hypothesis of reading of Dt 32.8-9 as monolatrous and post-exilic narrative, written in context of political and cultural subordination to the Persian hegemony, whose Empire depends relentlessly on the restoration and preservation of Judah. Dt 32,1-43 would answer for the sui generis characterization of the theology of the text that, despite the monolatrous theology embodied in the passage and the expressed horror at the idea of the nation of Yahweh to worship other gods. The textual composition is compelled to assume the thesis that Yahweh's exclusive ownership of Judahis due to the determination of `elyôn, which is then interpreted, as the hypostasis of Ahura Mazda and that, in geopolitical terms, embodies the very Persian Empire. It is assumed therefore that Dt 32.8-9 is a political-theological passage of legitimation of Judahite political-theological system in the light of the Persian geopolitical system.

  17. 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway

    International Nuclear Information System (INIS)

    Ma, Jun; Zhang, Lei; Li, Shanshan; Liu, Shulin; Ma, Cui; Li, Weiyang; Falck, J.R.; Manthati, Vijay L.; Reddy, D. Sudarshan; Medhora, Meetha; Jacobs, Elizabeth R.; Zhu, Daling

    2010-01-01

    Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. In the present study, we tested the potential of 8,9-EET and derivatives to protect pulmonary artery smooth muscle cells (PASMCs) from starvation induced apoptosis. We found 8,9-epoxy-eicos-11(Z)-enoic acid (8,9-EET analog (214)), but not 8,9-EET, increased cell viability, decreased activation of caspase-3 and caspase-9, and decreased TUNEL-positive cells or nuclear condensation induced by serum deprivation (SD) in PASMCs. These effects were reversed after blocking the Rho-kinase (ROCK) pathway with Y-27632 or HA-1077. Therefore, 8,9-EET analog (214) protects PASMC from serum deprivation-induced apoptosis, mediated at least in part via the ROCK pathway. Serum deprivation of PASMCs resulted in mitochondrial membrane depolarization, decreased expression of Bcl-2 and enhanced expression of Bax, all effects were reversed by 8,9-EET analog (214) in a ROCK dependent manner. Because 8,9-EET and not the 8,9-EET analog (214) protects pulmonary artery endothelial cells (PAECs), these observations suggest the potential to differentially promote apoptosis or survival with 8,9-EET or analogs in pulmonary arteries.

  18. 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Jun; Zhang, Lei; Li, Shanshan [Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081 (China); Liu, Shulin [Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150081 (China); Ma, Cui [Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081 (China); Li, Weiyang [Mudanjiang Medical College, Mudanjiang 157011 (China); Falck, J.R.; Manthati, Vijay L.; Reddy, D. Sudarshan [University of Texas Southwestern Medical Center, Dallas, TX 75390 (United States); Medhora, Meetha; Jacobs, Elizabeth R. [Division of Pulmonary and Critical Care, Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226 (United States); Zhu, Daling, E-mail: dalingz@yahoo.com [Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150081 (China)

    2010-08-15

    Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. In the present study, we tested the potential of 8,9-EET and derivatives to protect pulmonary artery smooth muscle cells (PASMCs) from starvation induced apoptosis. We found 8,9-epoxy-eicos-11(Z)-enoic acid (8,9-EET analog (214)), but not 8,9-EET, increased cell viability, decreased activation of caspase-3 and caspase-9, and decreased TUNEL-positive cells or nuclear condensation induced by serum deprivation (SD) in PASMCs. These effects were reversed after blocking the Rho-kinase (ROCK) pathway with Y-27632 or HA-1077. Therefore, 8,9-EET analog (214) protects PASMC from serum deprivation-induced apoptosis, mediated at least in part via the ROCK pathway. Serum deprivation of PASMCs resulted in mitochondrial membrane depolarization, decreased expression of Bcl-2 and enhanced expression of Bax, all effects were reversed by 8,9-EET analog (214) in a ROCK dependent manner. Because 8,9-EET and not the 8,9-EET analog (214) protects pulmonary artery endothelial cells (PAECs), these observations suggest the potential to differentially promote apoptosis or survival with 8,9-EET or analogs in pulmonary arteries.

  19. Poly[tetraaqua(μ6-9,10-dioxo-9,10-dihydroanthracene-1,4,5,8-tetracarboxylatodimanganese(II

    Directory of Open Access Journals (Sweden)

    Rui Xu

    2012-07-01

    Full Text Available The title complex, [Mn2(C18H4O10(H2O4]n, was synthesized from manganese(II chloride tetrahydrate and 9,10-dioxo-9,10-dihydroanthracene-1,4,5,8-tetracarboxylic acid (H4AQTC in water. The anthraquinone unit is located about a crystallographic center of inversion. Each asymmetric unit therefore contains one MnII atom, two water ligands and one half AQTC4− anion. The MnII atom is coordinated in a distorted octahedral geometry by four O atoms from three AQTC4− ligands and two water O atoms. Two of the carboxylate groups coordinate one MnII atom in a chelating mode, whereas the others each coordinate two MnII atoms. Each AQTC4− tetra-anion therefore coordinates six different MnII ions and, as a result, a three-dimensional coordination polymer is formed. O—H...O hydrogen bonds, some of them bifurcated, between water ligands and neighboring water or anthraquinone ligands are observed in the crystal structure.

  20. OSCAR experiment high-density network data report: Event 1 - April 8-9, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Dana, M.T.; Easter, R.C.; Thorp, J.M.

    1984-12-01

    The OSCAR (Oxidation and Scavenging Characteristics of April Rains) experiment, conducted during April 1981, was a cooperative field investigation of wet removal in cyclonic storm systems. The high-densiy component of OSCAR was located in northeast Indiana and included sequential precipitation chemistry measurements on a 100 by 100 km network, as well as airborne air chemistry and cloud chemistry measurements, surface air chemistry measurements, and supporting meteorological measurements. Four separate storm events were studied during the experiment. This report summarizes data taken by Pacific Northwest Laboratory (PNL) during the first storm event, April 8-9. The report contains the high-density network precipitation chemistry data, air chemistry data from the PNL aircraft, and meteorological data for the event, including standard National Weather Service products and radar data from the network. 4 references, 72 figures, 5 tables.

  1. Convenient synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester.

    Science.gov (United States)

    Crider, A M; Grubb, R; Bachmann, K A; Rawat, A K

    1981-12-01

    6-Nor-9,10-dihydrolysergic acid methyl ester (IV) was prepared by demethylation of 9,10-dihydrolysergic acid methyl ester (II) with 2,2,2-trichloroethyl chloroformate, followed by reduction of the intermediate carbamate (III) with zinc in acetic acid. The 6-ethyl-V and 6-n-propyl-VI derivatives were prepared by alkylation of IV with the appropriate halide. All of the ergoline derivatives were evaluated for stereotyped behavior in rats, with 6-nor-6-ethyl-9,10-dihydrolysergic acid methyl ester (V) being active but much less potent than apomorphine. Compound VI was evaluated for its effect on blood pressure; at a dose of 30 mg/kg ip, it significantly lowered, diastolic pressure in normotensive rats.

  2. 9,10-Dioxoanthracene-1,4-diyl bis(4-methylbenzenesulfonate

    Directory of Open Access Journals (Sweden)

    Sirirat Kokpol

    2012-05-01

    Full Text Available The title molecule, C28H20O8S2, has a T-shaped conformation. The central 9,10-anthraquinone moiety is bow-shaped with the two outer aromatic rings being inclined to one another by 13.99 (11°. The benzenesulfonate rings are inclined to one another by 47.35 (12°, and by 34.51 (11 and 17.88 (11° to the bridging aromatic ring of the 9,10-anthraquinone moiety. In the crystal, C—H...O interactions link the molecules into ribbons in [100].

  3. Crystal structure of tetraaquabis(8-chloro-9,10-dioxo-9,10-dihydroanthracene-1-carboxylato-κO1cobalt(II dihydrate

    Directory of Open Access Journals (Sweden)

    Wen-Juan Cai

    2014-10-01

    Full Text Available In the title complex, [Co(C15H6ClO42(H2O4]·2H2O, the CoII ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthraquinone-1-carboxylate anions and four water O atoms in a trans conformation, forming an irregular octahedral coordination geometry. This arrangement is stabilized by intramolecular O—H...O hydrogen bonds between water and carboxylate. Further O—H...O hydrogen bonds between coordinating and non-coordinating water and carboxylate produce layers of molecules that extend parallel to (001. The organic ligands project above and below the plane. Those ligands of adjacent planes are interdigitated and there are π–π interactions between them with centroid–centroid distances of 3.552 (2 and 3.767 (2 Å that generate a three-dimensional supramolecular structure.

  4. 42 CFR 9.10 - Occupational Health and Safety Program (OHSP) and biosafety requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Occupational Health and Safety Program (OHSP) and... SANCTUARY SYSTEM § 9.10 Occupational Health and Safety Program (OHSP) and biosafety requirements. (a) How are employee Occupational Health and Safety Program risks and concerns addressed? The sanctuary shall...

  5. LEVEL OF HABITUAL PHYSICAL ACTIVITY IN 8-9 YEARS OLD SCHOOLCHILDREN FROM SPAIN AND INDIA

    Directory of Open Access Journals (Sweden)

    Guillermo Felipe López Sánchez

    2016-01-01

    Full Text Available The level of physical activity of people is a very important issue internationally. The aim of this study was to analyze and compare the level of habitual physical activity in 8-9 years old schoolchildren from Spain and India. With this purpose, it was administered the questionnaire PACE (Physician-based Assessment and Counseling for Exercise in a sample of 85 schoolchildren (44 from Spain and 41 from India. The results showed that the sample studied does not do enough physical activity, according to the recommendations of the World Health Organization, as they do at least 60 minutes of physical activity; only an average of 3.13 days/week (SD=1.91. 8-year-old schoolchildren do more physical activity than 9-year-old schoolchildren in both countries; boys do more physical activity than girls in both countries; schoolchildren from India do more physical activity than schoolchildren from Spain. Therefore, it is concluded that the level of physical activity is insufficient, decreases slightly with the age and is higher in India.

  6. The Weatherization Assistant User's Manual (Version 8.9)

    Energy Technology Data Exchange (ETDEWEB)

    Gettings, Michael B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Malhotra, Mini [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ternes, Mark P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-01-01

    The Weatherization Assistant is a Windows-based energy audit software tool that was developed by Oak Ridge National Laboratory (ORNL) to help states and their local weatherization agencies implement the U.S. Department of Energy (DOE) Weatherization Assistance Program. The Weatherization Assistant is an umbrella program for two individual energy audits or measure selection programs: the National Energy Audit Tool (NEAT) for site-built single-family homes and the Manufactured Home Energy Audit (MHEA) for mobile homes. The Weatherization Assistant User's Manual documents the operation of the user interface for Version 8.9 of the software. This includes how to install and setup the software, navigate through the program, and initiate an energy audit. All of the user interface forms associated with the software and the data fields on these forms are described in detail. The manual is intended to be a training manual for new users of the Weatherization Assistant and as a reference manual for experienced users.

  7. Direct and ketone-sensitized photoconversion of 1-nitro-9,10-anthraquinone to 1-amino-9,10-anthraquinone mediated by donor radicals

    International Nuclear Information System (INIS)

    Goerner, Helmut; Gruen, Henry

    2010-01-01

    The full photoreduction of 1-nitro-2-R-9,10-anthraquinone (R = H: N1, methyl: N2) was studied in benzene, acetonitrile and acetonitrile-water mixtures in the presence of 2-propanol and triethylamine (TEA). The major photoproduct is the fluorescing 1-amino-2-R-AQ (A1, A2). The quantum yield of full reduction increases with the donor concentration, approaching Φ NH 2 =0.1. The intermediates involved are assigned on the basis of spectral and kinetic characteristics. The short-lived triplet state (≤20 ns) of N2 can be intercepted by 2-propanol or TEA, thereby forming the spectroscopically hidden donor radicals and the nitroAQ radicals which absorb at 400 and 540 nm; the latter band is due to the radical anion. The triplet state of N1 was not observed at room temperature, but the radical properties and decay in the nitrosoAQ are similar for N1 and N2. For donors in lower concentrations Φ NH 2 is strongly increased in the presence of benzophenone, acetophenone or acetone, approaching 0.22. The results under direct and sensitized conditions are compared and major dependences and the effects of mixtures of acetonitrile with water are outlined.

  8. Direct and ketone-sensitized photoconversion of 1-nitro-9,10-anthraquinone to 1-amino-9,10-anthraquinone mediated by donor radicals

    Energy Technology Data Exchange (ETDEWEB)

    Goerner, Helmut, E-mail: goerner@mpi-muelheim.mpg.de [Max-Planck-Institut fuer Bioanorganische Chemie, D-45413 Muelheim an der Ruhr (Germany); Gruen, Henry [Max-Planck-Institut fuer Bioanorganische Chemie, D-45413 Muelheim an der Ruhr (Germany)

    2010-02-18

    The full photoreduction of 1-nitro-2-R-9,10-anthraquinone (R = H: N1, methyl: N2) was studied in benzene, acetonitrile and acetonitrile-water mixtures in the presence of 2-propanol and triethylamine (TEA). The major photoproduct is the fluorescing 1-amino-2-R-AQ (A1, A2). The quantum yield of full reduction increases with the donor concentration, approaching {Phi}{sub NH{sub 2}}=0.1. The intermediates involved are assigned on the basis of spectral and kinetic characteristics. The short-lived triplet state ({<=}20 ns) of N2 can be intercepted by 2-propanol or TEA, thereby forming the spectroscopically hidden donor radicals and the nitroAQ radicals which absorb at 400 and 540 nm; the latter band is due to the radical anion. The triplet state of N1 was not observed at room temperature, but the radical properties and decay in the nitrosoAQ are similar for N1 and N2. For donors in lower concentrations {Phi}{sub NH{sub 2}} is strongly increased in the presence of benzophenone, acetophenone or acetone, approaching 0.22. The results under direct and sensitized conditions are compared and major dependences and the effects of mixtures of acetonitrile with water are outlined.

  9. PENGARUH INTENSITAS BERMAIN GAME TERHADAP TINGKAT KOGNITIF (KECERDASAN LOGIKA-MATEMATIKA USIA 8-9 TAHUN

    Directory of Open Access Journals (Sweden)

    Theresita Febriane Manggena

    2017-12-01

    Abstract The advance of technology could ease the people for work. One kind of this is gadget. Gadget is not only used by adult, yet the children too to access the game. The game also used to bolster the aspects of growth, either is cognitive growth. Cognitive growth is required to improve the brain power. The purpose of this research is to find out the effect of the intensity of playing games to cognitive level (Logical-Mathematical Intelegence for the children aged 8-9 years Logical-Mathematical Intelegence may be valued or represented by the numeracy skills. This research utilize quantitative and descriptive method by using several instrument such as math test and questionnaire. Analysis Data Technique, performed by using the normality test of kolmagrov-smirnov, shapiro-wilk and mann-whitney test. This research done in The Christian Primary School of Satya Wacana to 60 3rd graders pupils. The research to the respondent result that 30 pupils who playing games with average of time 4,9 hours a day and 4,5 hours a week have score of numeracy skills ≤ 70. While theother 30 pupils who playing games with verage of time 2,8 hours a day and 2,2 hours a week have score of numeracy skills >70. This data shows that the score 3 hours a day have a significant impact to cognitive level Likewise, duration of playing games 21 hours a week have a significant impact to cognitive level. Key words : Playing Game, Cognitive (Logical-Mathematical Intelegence , The ability of the brain.

  10. Rumpictuside A: Unusual 9,10-anthraquinone glucoside from Rumex pictus Forssk.

    Science.gov (United States)

    El-Kashak, Walaa A; Elshamy, Abdelsamed I; Mohamed, Tarik A; El Gendy, Abd El-Nasser G; Saleh, Ibrahim A; Umeyama, Akemi

    2017-08-07

    A new 8-ionized hydroxylated 9,10-anthraquinone namely, 1-hydroxy-3-methyl-9,10-anthraquinone-6-O-β-D-glucopyranoside-8-olate (Rumpictuside A, 1) along with five known flavonoids, apigenin 7-O-β-D-glucoside (2), vitexin (3), quercetin 3-O-β-D-glucouronide (4), orientin (5), and isorientin (6) were isolated from Rumex pictus. The structures of isolated compounds were identified by the extensive spectroscopic techniques such as, UV, FT-IR, 1D, 2D NMR and HR-FAB-ESI-MS. The ionized hydroxyl group in the new anthraquinone (1) was rarely found for anthraquinone glycosides isolated from natural sources. All the isolated compounds were found inactive against influenza A virus infection. Compounds 2-6 exhibited significant antioxidant activity against DPPH and ABTS + . The alcoholic extract exhibited moderate activity while the new anthraquinone 1 showed the lowest activity against both assays. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Representation of the properties 10 CrMoNiNb 9 10

    International Nuclear Information System (INIS)

    Dette, M.; Hahn, H.; Nieuwland, H.C.D.; Tichler, J.W.

    The high-temperature ferritic steal 10 CrMoNiNb 9 10 is used as structural material in nuclear steam generators. It is exposed to loads within the creep range. In order to resist safety also loads caused by incidents after long temperature stress, the time-independent stability parameters must not fall below specified minimum values. The material is characterised by the stability degree Nb/C+N and the niobium excess δ Nb. (orig.) [de

  12. Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate

    Directory of Open Access Journals (Sweden)

    Celia Bustos-Brito

    2016-09-01

    Full Text Available Chemical investigation of the leaves from Ageratina glabrata yielded four new thymol derivatives, namely: 10-benzoyloxy-8,9-dehydro-6-hydroxythymol isobutyrate (4, 10-benzoyloxy-8,9-dehydrothymol (5, 10-benzoyloxythymol (6 and 10-benzoyloxy-6,8-dihydroxy-9-isobutyryl-oxythymol (7. In addition, (8S-10-benzoyloxy-8,9-epoxy-6-hydroxythymol isobutyrate (1, together with other two already known thymol derivatives identified as 10-benzoyloxy-8,9-epoxy-6-methoxythymol isobutyrate (2 and 10-benzoyloxy-8,9-epoxythymol isobutyrate (3 were also obtained. In this paper, we report the structures and complete assignments of the 1H and 13C-NMR data of compounds 1–7, and the absolute configuration for compound 1, unambiguously established by single crystal X-ray diffraction, and evaluation of the Flack parameter. The in vitro antiprotozoal assay showed that compound 1 and its derivative 1a were the most potent antiamoebic and antigiardial compounds. Both compounds showed selectivity and good antiamoebic activity comparable to emetine and metronidazole, respectively, two antiprotozoal drugs used as positive controls. In relation to anti-propulsive effect, compound 1 and 1a showed inhibitory activity, with activities comparable to quercetin and compound 9, two natural antipropulsive compounds used as positive controls. These data suggest that compound 1 may play an important role in antidiarrheal properties of Ageratina glabrata.

  13. Conformational analysis of 9,10-dihydroanthracenes. Molecular mechanics calculations and /sup 13/C NMR

    Energy Technology Data Exchange (ETDEWEB)

    Rabideau, P.W.; Mooney, J.L.; Lipkowitz, K.B.

    1986-12-24

    The conformational analyses of 9, 10-dihydroanthracene and several of its methylated and ethylated derivatives are studied by empirical force field calculations (MM2 and MMPI). The computational results are considered in light of previous and current carbon NMR data. Model compounds are examined which involve fixed, planar, and boat-shaped conformations about the central ring, and these /sup 13/C NMR data are then compared with flexible systems. It is concluded that carbon chemical shifts and carbon-hydrogen coupling constants are consistent with the results of molecular mechanics calculations which indicate a greater tendency for planarity around the central ring than previously considered.

  14. White organic light-emitting diodes with 9, 10-bis (2-naphthyl) anthracene

    Energy Technology Data Exchange (ETDEWEB)

    Guan Yunxia; Niu Lianbin [Key Laboratory of Optical Engineering, College of Physics and Information Technology, Chongqing Normal University, Chongqing 400047 (China)], E-mail: gyxybsy@126.com, E-mail: niulb03@126.com

    2009-03-01

    White organic light-emitting diodes were fabricated by 9, 10-bis (2-naphthyl) anthracene (ADN) doped with Rubrene with a structure of ITO/copper phthalocyanine (CuPc) / NPB /ADN: Rubrene /Alq{sub 3} /CsF/Mg:Ag/Ag. Multilayer organic devices using AND and Rubrene as an emitting layer produced white emissions with good chromaticity and luminous efficiency as high as 5.93 cd/A. This performance can be explained by Foerster energy transfer from the blue-emitting host to the orange-emitting dopant.

  15. White organic light-emitting diodes with 9, 10-bis (2-naphthyl) anthracene

    International Nuclear Information System (INIS)

    Guan Yunxia; Niu Lianbin

    2009-01-01

    White organic light-emitting diodes were fabricated by 9, 10-bis (2-naphthyl) anthracene (ADN) doped with Rubrene with a structure of ITO/copper phthalocyanine (CuPc) / NPB /ADN: Rubrene /Alq 3 /CsF/Mg:Ag/Ag. Multilayer organic devices using AND and Rubrene as an emitting layer produced white emissions with good chromaticity and luminous efficiency as high as 5.93 cd/A. This performance can be explained by Foerster energy transfer from the blue-emitting host to the orange-emitting dopant.

  16. Enhanced mixing characteristics of GaAs/3,4,9,10-perylenetetracarboxylic dianhydride Schottky diodes

    International Nuclear Information System (INIS)

    Ginev, G; Riedl, T; Parashkov, R; Johannes, H-H; Kowalsky, W

    2003-01-01

    The influences on the mixing properties of GaAs Schottky diodes containing an organic 3,4,9,10-perylenetetracarboxylic dianhydride layer were investigated. The frequency conversion ability of the devices was determined by considering the I-V characteristics and high frequency reflection parameters by using a mixing technique operated in the microwave range. The results show that an organic layer with 20 nm thickness enhances the diode conversion gain for mixing applications by 3 dB and lowers the device operating bias voltage by 0.1 V. This process is related to the specific properties of the organic semiconductor and resulting organic-inorganic interface

  17. Crystal structure of 2-bromo-1,4-dihydroxy-9,10-anthraquinone

    Directory of Open Access Journals (Sweden)

    Wataru Furukawa

    2014-10-01

    Full Text Available In an attempt to brominate 1,4-dipropoxy-9,10-anthraquinone, a mixture of products, including the title compound, C14H7BrO4, was obtained. The molecule is essentially planar (r.m.s. deviation = 0.029 Å and two intramolecular O—H...O hydrogen bonds occur. In the crystal, the molecules are linked by weak C—H...O hydrogen bonds, Br...O contacts [3.240 (5 Å], and π–π stacking interactions [shortest centroid–centroid separation = 3.562 (4 Å], generating a three-dimensional network.

  18. The radiation chemistry of aqueous solutions of sodium 9,10-anthraquinone-2-sulfonate

    International Nuclear Information System (INIS)

    Burchill, C.E.; Smith, D.M.; Charlton, J.L.

    1976-01-01

    The 60 Co γ-radiolysis of aqueous solutions of sodium 9,10-anthraquinone-2-sulfonate has been studied in acidic, unbuffered, and alkaline conditions and with addition of N 2 O and 2-propanol. Mechanisms are proposed to account for the yields of H 2 O 2 and hydroxylated anthraquinone sulfonates. In neutral solution, in the absence of O 2 , the OH and e - adducts undergo preferential cross termination. Reduction of the OH adduct leads to dehydration and regeneration of the quinone. (author)

  19. Energetic effects of ether and ketone functional groups in 9,10-dihydroanthracene compound

    International Nuclear Information System (INIS)

    Freitas, Vera L.S.; Gomes, Jose R.B.; Ribeiro da Silva, Maria D.M.C.

    2010-01-01

    The energetic effects caused by replacing one of the methylene groups in the 9,10-dihydroanthracene by ether or ketone functional groups yielding xanthene and anthrone species, respectively, were determined from direct comparison of the standard (p o = 0.1 MPa) molar enthalpies of formation in the gaseous phase, at T = 298.15 K, of these compounds. The experimental static-bomb combustion calorimetry and Calvet microcalorimetry and the computational G3(MP2)//B3LYP method were used to get the standard molar gas-phase enthalpies of formation of xanthene, (41.8 ± 3.5) kJ . mol -1 , and anthrone, (31.4 ± 3.2) kJ . mol -1 . The enthalpic increments for the substitution of methylene by ether and ketone in the parent polycyclic compound (9,10-dihydroanthracene) are -(117.9 ± 5.5) kJ . mol -1 and -(128.3 ± 5.4) kJ . mol -1 , respectively.

  20. Systematic analysis of above-barrier fusion of 9,10,11Be+209Bi

    International Nuclear Information System (INIS)

    Hinde, D. J.; Dasgupta, M.

    2010-01-01

    Measurements of fusion for 9,10,11 Be allow testing of the relative importance to fusion and breakup of the α-cluster structure found in all these Be isotopes, compared with the neutron-halo structure only present for 11 Be. However, disagreements exist among different published experimental data sets for the reactions of 9,10,11 Be with 209 Bi. Accurate measurements of above-barrier cross sections for the products of complete fusion (fission and evaporation residues) in the reaction of 9 Be with 209 Bi and 208 Pb provide the basis for a reanalysis of above-barrier fusion for 10,11 Be+ 209 Bi. This includes procedures making full use of the higher precision stable beam data and resolves many of the disagreements. The improved self-consistency of the analysis allows investigation of the experimental average fusion barriers. Although showing some scatter, these suggest a higher barrier for the neutron halo nucleus 11 Be. Comparison of published cross sections for fusion associated with capture of all the charge of the projectile suggest that all these Be isotopes show significant suppression of complete fusion, a surprising result given that the α-breakup threshold energies are 1.57 MeV for 9 Be but over 7 MeV for 10,11 Be. Further experimental studies to investigate in more detail the division between complete and incomplete fusion for reactions of 10,11 Be are needed.

  1. Planar conjugated polymers containing 9,10-disubstituted phenanthrene units for efficient polymer solar cells.

    Science.gov (United States)

    Li, Guangwu; Kang, Chong; Li, Cuihong; Lu, Zhen; Zhang, Jicheng; Gong, Xue; Zhao, Guangyao; Dong, Huanli; Hu, Wenping; Bo, Zhishan

    2014-06-01

    Four novel conjugated polymers (P1-4) with 9,10-disubstituted phenanthrene (PhA) as the donor unit and 5,6-bis(octyloxy)benzothiadiazole as the acceptor unit are synthesized and characterized. These polymers are of medium bandgaps (2.0 eV), low-lying HOMO energy levels (below -5.3 eV), and high hole mobilities (in the range of 3.6 × 10(-3) to 0.02 cm(2) V(-1) s(-1) ). Bulk heterojunction (BHJ) polymer solar cells (PSCs) with P1-4:PC71 BM blends as the active layer and an alcohol-soluble fullerene derivative (FN-C60) as the interfacial layer between the active layer and cathode give the best power conversion efficiency (PCE) of 4.24%, indicating that 9,10-disubstituted PhA are potential donor materials for high-efficiency BHJ PSCs. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Prevalence of overweight, obesity and thinness in 9-10 year old children in Mauritius.

    Science.gov (United States)

    Caleyachetty, Rishi; Rudnicka, Alicja R; Echouffo-Tcheugui, Justin B; Siegel, Karen R; Richards, Nigel; Whincup, Peter H

    2012-07-23

    To document the prevalence of overweight, obesity and thinness in 9-10 year old children in Mauritius. 412 boys and 429 girls aged 9-10 years from 23 primary schools were selected using stratified cluster random sampling. All data was cross-sectional and collected via anthropometry and self-administered questionnaire. Outcome measures were BMI (kg/m2), prevalence of overweight, obesity (International Obesity Task Force definitions) and thinness (low BMI for age). Linear and logistic regression analyses, accounting for clustering at the school level, were used to assess associations between gender, ethnicity, school location, and school's academic performance (average) to each outcome measure. The distribution of BMI was marginally skewed with a more pronounced positive tail in the girls. Median BMI was 15.6 kg/m2 in boys and 15.4 kg/m2 in girls, respectively. In boys, prevalence of overweight was 15.8% (95% CI: 12.6, 19.6), prevalence of obesity 4.9% (95% CI: 3.2, 7.4) and prevalence of thinness 12.4% (95% CI: 9.5, 15.9). Among girls, 18.9% (95% CI: 15.5, 22.9) were overweight, 5.1% (95% CI: 3.4, 7.7) were obese and 13.1% (95% CI: 10.2, 16.6) were thin. Urban children had a slightly higher mean BMI than rural children (0.5 kg/m2, 95% CI: 0.01, 1.00) and were nearly twice as likely to be obese (6.7% vs. 4.0%; adjusted odds ratio 1.6; 95% CI: 0.9, 3.5). Creole children were less likely to be classified as thin compared to Indian children (adjusted odds ratio 0.3, 95% CI: 0.2, 0.6). Mauritius is currently in the midst of nutritional transition with both a high prevalence of overweight and thinness in children aged 9-10 years. The coexistence of children representing opposite sides of the energy balance equation presents a unique challenge for policy and interventions. Further exploration is needed to understand the specific causes of the double burden of malnutrition and to make appropriate policy recommendations.

  3. British Society of Neuroradiologists, annual meeting, Hilton National Hotel, Stansted Airport, Essex, UK, 8-9 October 1993. Abstracts

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Eighteen abstracts of scientific papers are presented which were read at the Annual Meeting of the British Society of Neuroradiologists, held in Essex from 8-9 October 1993, dealing with the diagnostic evaluation of a variety of brain diseases. (orig.)

  4. Photosensitized Oxidation of 9,10-Dimethylanthracene on Dye-Doped Silica Composites

    Directory of Open Access Journals (Sweden)

    Elim Albiter

    2012-01-01

    Full Text Available A series of cationic dyes, methylene blue (MB, safranin O (SF, toluidine blue (TB, and neutral red (NR, were successfully incorporated into a silica matrix by using ultrasound irradiation during the Stöber process. Several analyses were performed, including scanning dynamic light scattering (DLS, electron microscopy (SEM, nitrogen physisorption, FTIR spectroscopy, UV-vis, and diffuse reflectance spectroscopy. The entrapped dyes on silica were evaluated in singlet oxygen (1O2 generation under visible light irradiation, by means of the photosensitized oxidation of 9,10-dimethylanthracene (DMA. According to the results, the photocatalytic performance of the silica composites was improved, and the leakage of the dye from the particles was suppressed. Among these four different types of dye-doped silica composites, the SiO2-SF composite showed the most efficient delivery of 1O2.

  5. Polyether precursors of molecular recognition systems based on the 9,10-anthraquinone moiety

    Science.gov (United States)

    Wcisło, Anna; Cirocka, Anna; Zarzeczańska, Dorota; Niedziałkowski, Paweł; Nakonieczna, Sandra; Ossowski, Tadeusz

    2015-02-01

    A series of novel polyether derivatives of 9,10-anthraquinone (AQ) was synthesized and characterized by means of UV-Vis spectroscopy, acid-base titration and complexometric titration. The results were compared with 1-NEt2AQ and 1-NHEtAQ - model compounds of alkylaminoanthraquinones. Acetonitrile and methanol were used as solvents for determination of spectroscopic and acid-base properties. Complexometric titrations were carried out exclusively in acetonitrile. Spectral characteristic of these compounds strongly depends on pH. Addition of acid causes the decrease of absorption intensity and in some cases also a shift of the visible range band. The weakest base is the compound (2), and the strongest - compound (1), both in methanol and acetonitrile solution. The introduction of an additional substituent in the position 8 of the anthraquinone compound increases its basicity. The presence of metal ions causes changes in intensity of absorption (decrease for compounds (2) and (3) and increase with bathochromic shift for (1) and (4)). For the determination of the coordination properties aluminum (III) ions were chosen. The highest complex stability constant with Al (III) ions is observed for compound (1), and the weakest for compound (3). The elongation of the polyether chain decreases the stability of the complex formed.

  6. Strength behaviour of 10CrMo9.10 steel in nonsteady-state applications

    International Nuclear Information System (INIS)

    Seidel, C.

    2 testing runs with cyclic temperature increase were conducted on steel 10CrMo9.10 samples, i.e., at 500 degC and cyclic increase by 10, 25 and 50 degC, and at 550 degC and cyclic increase by 50 degC. Long-term strength was studied under a strain of 6.1 to 25.6 kp/mm 2 for 22,000 hours and the effect of periodical unloading was investigated on long-term strength at 550 degC. Sample loading and unloading proceeded within the range of 8.8 to 24.7 kp/mm 2 at an unloading rate of 8 to 100 %/min. Steel lifetime was not affected by the number of cycles. The effect of the changing load and of constant temperature without load on the long-term strength of the steel at 550 degC is shown graphically. The results showed a clear dependence of steel life on dwell time at the given temperature without load. (J.P.)

  7. Workshop on Molecule Assisted Recombination and Other Processes in Fusion Divertor Plasmas, September 8-9, 2000

    International Nuclear Information System (INIS)

    Janev, R.K.; Schultz, D.R.

    2000-01-01

    A brief proceedings of the two-day Workshop on Molecule Assisted Recombination and Other Processes in Fusion Divertor Plasmas, organized by the ORNL Controlled Fusion Atomic Data Center on September 8-9, 2000, is presented. The conclusions and recommendations of the workshop regarding the topics discussed and the collaboration of the U.S. fusion research and atomic physics communities are also summarized

  8. Mechanism and kinetic properties for the OH-initiated atmospheric oxidation degradation of 9,10-Dichlorophenanthrene

    Energy Technology Data Exchange (ETDEWEB)

    Dang, Juan; Shi, Xiangli; Zhang, Qingzhu, E-mail: zqz@sdu.edu.cn; Hu, Jingtian; Wang, Wenxing

    2015-02-01

    Chlorinated polycyclic aromatic hydrocarbons (ClPAHs) have become a serious environmental concern due to their widespread occurrence and dioxin-like toxicities. In this work, the mechanism of the OH-initiated atmospheric oxidation degradation of 9,10-dichlorophenanthrene (9,10-Cl{sub 2}Phe) was investigated by using high-accuracy quantum chemistry calculations. The rate constants of the crucial elementary reactions were determined by the Rice–Ramsperger–Kassel–Marcus (RRKM) theory. The theoretical results were compared with the available experimental data. The main oxidation products are a group of ring-retaining and ring-opening compounds including chlorophenanthrols, 9,10-dichlorophenanthrene-3,4-dione, dialdehydes, chlorophenanthrenequinones, nitro-9,10-Cl{sub 2}Phe and epoxides et al. The overall rate constant of the OH addition reaction is 2.35 × 10{sup −12} cm{sup 3} molecule{sup −1} s{sup −1} at 298 K and 1 atm. The atmospheric lifetime of 9,10-Cl{sub 2}Phe determined by OH radicals is about 5.05 days. This study provides a comprehensive investigation of the OH-initiated oxidation degradation of 9,10-Cl{sub 2}Phe and should contribute to clarifying its atmospheric fate. - Highlights: • We studied a comprehensive mechanism of OH-initiated degradation of 9,10-Cl{sub 2}Phe. • The atmospheric lifetime of 9,10-Cl{sub 2}Phe determined by OH radical is about 5.05 d. • The rate constants of the crucial elementary steps were evaluated. • Water plays an important role in the formation of nitro-9,10-Cl{sub 2}Phe.

  9. Due ritratti della moglie di Giobbe (Gb 2,9-10

    Directory of Open Access Journals (Sweden)

    Toloni, Giancarlo

    2015-12-01

    Full Text Available Even Job's wife (Job 2:9-10, like the minor characters of the Hebrew Bible stories, does not play at all an insignificant role in the story of her husband, but she is however functional to better understand the author's design. In the traditional interpretation, based mostly on the Masoretic Text (MT, she was caught in a pattern that drew the negative opinion of the critics, perhaps the result of a misogynistic view, of Judeo-Hellenistic matrix, and then she appeared as hostile to Job, the righteous sufferer, for the aversion to the unconditional faithfulness of this man. Now, here we wanted to re-read this controversial figure, first of all starting from the received witnesses by both streams of the textual tradition, Jewish (MT and Greek (Old Greek = OG. In the first case, the words of his wife sound like an invitation to Job to curse Yahweh, responsible for his unjust suffering; in the second, however, they urge him to cry out to God his innocent suffering, even if he should be at the cost of being punished by death. So, two different portraits of woman - if not opposites - are derived from that, and her role in Job's story is defined negatively or positively, according to the archetype that is supposed.Tampoco la mujer de Job (Job 2,9-10, como sucede con otros personajes menores de las historias de la Biblia hebrea, juega un papel insignificante en la historia de su marido, sino que es relevante para entender mejor la intención del autor. En la interpretación tradicional, principalmente basada en el Texto Masorético (TM, ella estaba encuadrada dentro de un esquema que le atraía el juicio negativo de la crítica, fruto tal vez de una visión misógina de matriz judeo-helenística, y aparecía como hostil a Job, el justo sufridor, por la aversión a la fe incondicional de este. Ahora queremos revisar aquí esta controvertida figura, primero de todo a la luz de los testimonios de las dos ramas de la tradición textual hebrea (TM y griega

  10. Mechanism and kinetic properties for the OH-initiated atmospheric oxidation degradation of 9,10-Dichlorophenanthrene.

    Science.gov (United States)

    Dang, Juan; Shi, Xiangli; Zhang, Qingzhu; Hu, Jingtian; Wang, Wenxing

    2015-02-01

    Chlorinated polycyclic aromatic hydrocarbons (ClPAHs) have become a serious environmental concern due to their widespread occurrence and dioxin-like toxicities. In this work, the mechanism of the OH-initiated atmospheric oxidation degradation of 9,10-dichlorophenanthrene (9,10-Cl₂Phe) was investigated by using high-accuracy quantum chemistry calculations. The rate constants of the crucial elementary reactions were determined by the Rice-Ramsperger-Kassel-Marcus (RRKM) theory. The theoretical results were compared with the available experimental data. The main oxidation products are a group of ring-retaining and ring-opening compounds including chlorophenanthrols, 9,10-dichlorophenanthrene-3,4-dione, dialdehydes, chlorophenanthrenequinones, nitro-9,10-Cl₂Phe and epoxides et al. The overall rate constant of the OH addition reaction is 2.35 × 10(-12)cm(3) molecule(-1)s(-1) at 298 K and 1 atm. The atmospheric lifetime of 9,10-Cl₂Phe determined by OH radicals is about 5.05 days. This study provides a comprehensive investigation of the OH-initiated oxidation degradation of 9,10-Cl₂Phe and should contribute to clarifying its atmospheric fate. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Major earthquake of Friday March 11, 2011, magnitude 8.9 at 5:46 UT, off Honshu island (Japan)

    International Nuclear Information System (INIS)

    2011-01-01

    On Friday March 11, 2011, at 5:46 UT (2:46 PM local time), a magnitude 8.9 earthquake took place at 80 km east of Honshu island (Japan). The earthquake affected a large part of the Honshu territory and led to the automatic emergency shutdown of all nuclear power plants of the east coast. This paper recalls first the seismo-tectonic and historical seismic context of the Japan archipelago and the first analyses of the Tohoku earthquake impact on nuclear facilities. At the time of publication of this information report, no radioactive release in the environment and no anomaly at the Tokai-Mura and Rokkasho-Mura sites were mentioned. However, the evacuation of populations in a 3 to 10 km area around the Fukushima-Dai-ichi power plant had been ordered by the Governor as preventive measure, which made one think that the situation at this specific site was particularly worrying. (J.S.)

  12. Isotope separation of relativistic projectile fragments as well as cross section measurements on 8,9,11Li secondary beams

    International Nuclear Information System (INIS)

    Blank, B.

    1991-06-01

    In the framework of this thesis the method of the 'momentum-loss achromate' was for the first time tested at relativistic energies. This experiment is presented in chapter 2 of the thesis. In a second experiment the method was then used, in order to make secondary beams of 8,9,11 Li available. With these secondary beams cross section measurements were performed, from which beside information on the nuclear radii of these nuclei also further information on the internal structure of the lithium isotopes can be derived. This experiment is described in chapter 3 of the thesis. In the framework of these two experiments for the applied heavy ions energy-loss measurements were performed. The results of these measurements are presented in chapter 4. (orig.) [de

  13. (10R,13R-17-(6-Hydroxy-5-methylheptan-2-yl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol hemihydrate: a bioactive steroid isolated from the Indian herb Artemisia reticulata

    Directory of Open Access Journals (Sweden)

    A. K. Bauri

    2017-08-01

    Full Text Available The title tetracyclic steroidal compound, C27H46O2·0.5H2O, crystallized as a monohydrate with two independent molecules (1 and 2 in the asymmetric unit. In both molecules, the conformations of the three cyclohexane rings (A, B and C are chair, half-chair and chair, respectively. The fourth ring, D, has a twisted conformation on the bond linking the D and C rings. The crystal structure is stabilized by hydrogen bonding with the two independent molecules being linked through the solvent water molecule via various O—H...O hydrogen bonds, forming layers parallel to (-101.

  14. 26 CFR 5c.168(f)(8)-9 - Pass-through leases-transfer of only the investment tax credit to a party other than the ultimate...

    Science.gov (United States)

    2010-04-01

    ... investment tax credit to a party other than the ultimate user of the property. [Reserved] 5c.168(f)(8)-9...) INCOME TAX (CONTINUED) TEMPORARY INCOME TAX REGULATIONS UNDER THE ECONOMIC RECOVERY TAX ACT OF 1981 § 5c.168(f)(8)-9 Pass-through leases—transfer of only the investment tax credit to a party other than the...

  15. Dechlorination and chlorine rearrangement of 1,2,5,5,6,9,10-heptachlorodecane mediated by the whole pumpkin seedlings.

    Science.gov (United States)

    Li, Yanlin; Hou, Xingwang; Yu, Miao; Zhou, Qunfang; Liu, Jiyan; Schnoor, Jerald L; Jiang, Guibin

    2017-05-01

    Short chain chlorinated paraffins (SCCPs) are ubiquitously present as persistent organic pollutants in the environment. However, little information on the interaction of SCCPs with plants is currently available. In this work, young pumpkin plants (Cucurbita maxima × C. Moschata) were hydroponically exposed to the congener of chlorinated decane, 1,2,5,5,6,9,10-heptachlorodecane (1,2,5,5,6,9,10-HepCD), to investigate the uptake, translocation and transformation of chlorinated decanes in the intact plants. It was found that parent HepCD was taken up by the pumpkin roots, translocated from root to shoots, and phytovolatilized from pumpkin plants to air via the plant transpiration flux. Our data suggested that dechlorination of 1,2,5,5,6,9,10-HepCD to lower chlorinated decanes and rearrangement of chlorine atoms in the molecule were all mediated by the whole pumpkin seedlings. Chlorinated decanes were found in the shoots and roots of blank controls, indicating that chlorinated decanes in the air could be absorbed by leaves and translocated from shoots to roots. Lower chlorinated congeners (C 10 H 17 Cl 5 ) tended to detain in air compared to higher chlorinated congeners (C 10 H 16 Cl 6 and other C 10 H 15 Cl 7 ). Potential transformation pathway and behavior of 1,2,5,5,6,9,10-HepCD in pumpkin were proposed based on these experiments. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Philostr., Her. XXXV 9-10: ¿un testimonio de Eurísaces de Sófocles?

    Directory of Open Access Journals (Sweden)

    Miryam Librán Moreno

    2005-06-01

    Full Text Available Philostr. Her.. XXXV 9-10 may preserve hints of a rhesis from Sophocles' Eurysaces. Taking that as a departure point, a reconstruction of the general lines of this play is attempted from the evidence supplied by Accius, Pacuvius and Justin, as interpreted through the narrative pattern evinced in Oedipus at Colonus.

  17. Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease.

    Directory of Open Access Journals (Sweden)

    Alison Marshall

    Full Text Available The IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 play a key role in many inflammatory conditions, particularly those mediated by T cells. Therefore, the production of these chemokines in peripheral tissues could be instrumental in the pathophysiology of tissue-specific immunological diseases such as oral lichen planus (OLP. In the present study, we assessed the production of keratinocyte-derived CXCL9/10/11 under basal and inflammatory conditions and investigated whether these chemokines were involved in the pathogenesis of OLP. We used semi-quantitative PCR, ELISA, chemotaxis assays, and fluorescence-activated cell sorting (FACS to assess the expression and functional role of CXCL9/10/11 in oral keratinocytes (three strains of normal human oral keratinocytes (NHOK, and the H357 oral cancer cell line in the presence or absence of IFN-γ. CXCL9/10/11 were also assessed in tissues from normal patients and those with oral lichen planus (OLP. The time course study in oral keratinocytes treated with IFN-γ showed that expression of CXCL9/10/11 chemokines was significantly enhanced by IFN-γ in a time-dependent manner. In particular, CXCL10, a prominent chemokine that was overexpressed by IFN-γ-stimulated NHOK, was able to effectively recruit CD4 lymphocytes, mainly CD4+CD45RA- cells. Significantly higher levels of CXCL9/10/11 were found in tissues from patients with OLP compared to normal oral mucosa. Taken together, the results demonstrate that normal oral keratinocytes produce chemotactic molecules that mediate T cell recruitment. This study furthers understanding of chemokine production in oral keratinocytes and their role in the pathophysiology of oral mucosa, with particular relevance to OLP.

  18. Low-Reynolds Number Aerodynamics of an 8.9 Percent Scale Semispan Swept Wing for Assessment of Icing Effects

    Science.gov (United States)

    Broeren, Andy P.; Woodard, Brian S.; Diebold, Jeffrey M.; Moens, Frederic

    2017-01-01

    Aerodynamic assessment of icing effects on swept wings is an important component of a larger effort to improve three-dimensional icing simulation capabilities. An understanding of ice-shape geometric fidelity and Reynolds and Mach number effects on the iced-wing aerodynamics is needed to guide the development and validation of ice-accretion simulation tools. To this end, wind-tunnel testing and computational flow simulations were carried out for an 8.9 percent-scale semispan wing based upon the Common Research Model airplane configuration. The wind-tunnel testing was conducted at the Wichita State University 7 by 10 ft Beech wind tunnel from Reynolds numbers of 0.8×10(exp 6) to 2.4×10(exp 6) and corresponding Mach numbers of 0.09 to 0.27. This paper presents the results of initial studies investigating the model mounting configuration, clean-wing aerodynamics and effects of artificial ice roughness. Four different model mounting configurations were considered and a circular splitter plate combined with a streamlined shroud was selected as the baseline geometry for the remainder of the experiments and computational simulations. A detailed study of the clean-wing aerodynamics and stall characteristics was made. In all cases, the flow over the outboard sections of the wing separated as the wing stalled with the inboard sections near the root maintaining attached flow. Computational flow simulations were carried out with the ONERA elsA software that solves the compressible, threedimensional RANS equations. The computations were carried out in either fully turbulent mode or with natural transition. Better agreement between the experimental and computational results was obtained when considering computations with free transition compared to turbulent solutions. These results indicate that experimental evolution of the clean wing performance coefficients were due to the effect of three-dimensional transition location and that this must be taken into account for future

  19. Relationship between 8/9-yr-old school children BMI, parents' BMI and educational level: a cross sectional survey

    Directory of Open Access Journals (Sweden)

    Pilato Valentina

    2011-07-01

    Full Text Available Abstract Background Parents are responsible not only for the genetic structure of their children, but also for passing onto them their behaviours and attitudes toward life. The aim of this study was to analyse the connection between school-age children's obesity and that of their parents as well as between child obesity and parents' educational level, as a proxy indicator of the socio-economic status (SES of families in Tuscany. Methods The children sample was selected from "OKkio alla Salute 2010" (a cross sectional survey carried out by the Italian Institute of Health and consisted of 1,751 (922 males and 855 females 8-9 year-old school children. Weight and height were measured by ad hoc trained personnel, and Body Mass Index (BMI categories were calculated using Cole et al.'s cut-off. Parents' weight, height and educational level were collected by a self-administered questionnaire. The educational levels were classified as high, medium and low. Results The prevalence of obese children increased along the parents' BMI category: from 1.4% for underweight mothers to 30.3% for obese mothers and from 4% for under-normal-weight fathers to 23.9% for obese fathers (p Conclusion Parents' obesity and the cultural resources of the family, particularly the father's, seem to influence the prevalence of overweight and obesity in Tuscan children.

  20. 75 FR 47199 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-10 Series Airplanes, DC-9-30...

    Science.gov (United States)

    2010-08-05

    ... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-10 Series Airplanes, DC-9-30 Series... existing airworthiness directive (AD), which applies to all McDonnell Douglas Model DC-9-10 series..., 2010). That AD applies to all McDonnell Douglas Corporation Model DC-9-10 series airplanes, DC-9-30...

  1. Pulse radiolytic one-electron reduction of 1,4-amino and hydroxy disubstituted 9,10-anthraquinones

    International Nuclear Information System (INIS)

    Pal, H.; Palit, D.K.; Mukherjee, T.; Mittal, J.P.

    1992-01-01

    The semiquinone radicals produced by one-electron reduction of 1-amino-4-hydroxy-9,10-anthraquinone and 1,4-diamino-9,10-anthraquinone have been studied in aqueous-organic mixed solvent using pulse radiolysis technique. Spectroscopic characteristics, kinetic characteristics of formation and decay, acid/base behaviour and redox characteristics of the semiquinones have been investigated and compared with those of some similar systems studied earlier. It has been shown that the variation of the disproportionation equilibria involving the reduced semiquinone radicals, the parent quinone and the fully reduced hydroquinone with pH of the solutions follow a similar trend as observed in the case of other dihydroxy quinones. Stability of the semiquinones over a broad pH range and their thermodynamic properties have been correlated. (Author)

  2. New phenanthrene and 9, 10-dihydrophenanthrene derivatives from the stems of Dendrobium officinale with their cytotoxic activities.

    Science.gov (United States)

    Zhao, Gui-Yun; Deng, Bo-Wen; Zhang, Chong-Yu; Cui, Yi-Da; Bi, Jia-Yi; Zhang, Guo-Gang

    2018-01-01

    Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1-2) with six known congeners (3-8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit through a dioxane bridge, respectively. Their structures were determined by comprehensive NMR spectroscopic data, the absolute configuration of new compounds were determined by comparing their experimental and calculated ECD for the first time. All the compounds were investigated contains two cancer cell lines (HI-60, THP-1). All the isolates showed cytotoxicity, especially compound 4 showed markedly cytotoxic activities against HI-60 and THP-1 cell lines with IC 50 values of 11.96 and 8.92 μM.

  3. Abstracts of the Mini-Symposium on Stability and Bifurcation in Fluid Motions September 9-10, 1994, Tokai, Japan

    International Nuclear Information System (INIS)

    Fujimura, Kaoru

    1995-01-01

    This is the abstracts of the Mini-Symposium on Stability and Bifurcation in Fluid Motions held on September 9-10, 1994 at the Tokai Establishment of JAERI and the Tokai Kaikan. Sixteen talks were given on various important subjects related with stability and bifurcation phenomena in fluids. All of them are theoretical and numerical analyses involving linear stability analysis, weakly nonlinear analysis, bifurcation analysis, and direct computation of nonlinearly equilibrium solutions. (author)

  4. Abstracts of the Mini-Symposium on Stability and Bifurcation in Fluid Motions September 9-10, 1994, Tokai, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Fujimura, Kaoru [ed.; Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1995-01-01

    This is the abstracts of the Mini-Symposium on Stability and Bifurcation in Fluid Motions held on September 9-10, 1994 at the Tokai Establishment of JAERI and the Tokai Kaikan. Sixteen talks were given on various important subjects related with stability and bifurcation phenomena in fluids. All of them are theoretical and numerical analyses involving linear stability analysis, weakly nonlinear analysis, bifurcation analysis, and direct computation of nonlinearly equilibrium solutions. (author).

  5. Relationship between 8/9-yr-old school children BMI, parents' BMI and educational level: a cross sectional survey.

    Science.gov (United States)

    Lazzeri, Giacomo; Pammolli, Andrea; Pilato, Valentina; Giacchi, Mariano V

    2011-07-19

    Parents are responsible not only for the genetic structure of their children, but also for passing onto them their behaviours and attitudes toward life. The aim of this study was to analyse the connection between school-age children's obesity and that of their parents as well as between child obesity and parents' educational level, as a proxy indicator of the socio-economic status (SES) of families in Tuscany. The children sample was selected from "OKkio alla Salute 2010" (a cross sectional survey carried out by the Italian Institute of Health) and consisted of 1,751 (922 males and 855 females) 8-9 year-old school children. Weight and height were measured by ad hoc trained personnel, and Body Mass Index (BMI) categories were calculated using Cole et al.'s cut-off. Parents' weight, height and educational level were collected by a self-administered questionnaire. The educational levels were classified as high, medium and low. The prevalence of obese children increased along the parents' BMI category: from 1.4% for underweight mothers to 30.3% for obese mothers and from 4% for under-normal-weight fathers to 23.9% for obese fathers (p parents' educational level and child obesity, the lowest educational level corresponding to the highest prevalence of obese children: 9.3% for mothers with a low educational level compared to 5.8% for mothers with a high educational level (p = 0.15); similarly, the corresponding prevalence for fathers was 9.5% compared to 4.5% (p = 0.03). Parents' obesity and the cultural resources of the family, particularly the father's, seem to influence the prevalence of overweight and obesity in Tuscan children.

  6. A conserved function of the zinc finger transcription factor Sp8/9 in allometric appendage growth in the milkweed bug Oncopeltus fasciatus.

    Science.gov (United States)

    Schaeper, Nina D; Prpic, Nikola-Michael; Wimmer, Ernst A

    2009-08-01

    The genes encoding the closely related zinc finger transcription factors Buttonhead (Btd) and D-Sp1 are expressed in the developing limb primordia of Drosophila melanogaster and are required for normal growth of the legs. The D-Sp1 homolog of the red flour beetle Tribolium castaneum, Sp8 (appropriately termed Sp8/9), is also required for the proper growth of the leg segments. Here we report on the isolation and functional study of the Sp8/9 gene from the milkweed bug Oncopeltus fasciatus. We show that Sp8/9 is expressed in the developing appendages throughout development and that the downregulation of Sp8/9 via RNAi leads to antennae, rostrum, and legs with shortened and fused segments. This supports a conserved role of Sp8/9 in allometric leg segment growth. However, all leg segments including the claws are present and the expression of the leg genes Distal-less, dachshund, and homothorax are proportionally normal, thus providing no evidence for a role of Sp8/9 in appendage specification.

  7. Flood-inundation maps for an 8.9-mile reach of the South Fork Little River at Hopkinsville, Kentucky

    Science.gov (United States)

    Lant, Jeremiah G.

    2013-01-01

    Digital flood-inundation maps for an 8.9-mile reach of South Fork Little River at Hopkinsville, Kentucky, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Hopkinsville Community Development Services. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at South Fork Little River at Highway 68 By-Pass at Hopkinsville, Kentucky (station no. 03437495). Current conditions for the USGS streamgage may be obtained online at the USGS National Water Information System site (http://waterdata.usgs.gov/nwis/inventory?agency_code=USGS&site_no=03437495). In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often co-located at USGS streamgages. The forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the South Fork Little River reach by using HEC-RAS, a one-dimensional step-backwater model developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated by using the most current (2012) stage-discharge relation at the South Fork Little River at Highway 68 By-Pass at Hopkinsville, Kentucky, streamgage and measurements collected during recent flood events. The calibrated model was then used to calculate 13 water-surface profiles for a sequence of flood stages, most at 1-foot intervals, referenced to the streamgage datum and ranging from a stage near bank full to the estimated elevation of the 1.0-percent annual exceedance

  8. Organic-inorganic semiconductor devices and 3, 4, 9, 10 perylenetetracarboxylic dianhydride: an early history of organic electronics

    International Nuclear Information System (INIS)

    Forrest, S R

    2003-01-01

    The demonstration, over 20 years ago, of an organic-inorganic heterojunction (OI HJ) device along with investigations of the growth and physical properties of the archetypal crystalline molecular organic semiconductor 3, 4, 9, 10 perylenetetracarboxylic dianhydride are discussed. Possible applications of OI HJ devices are introduced and the dramatic change in conductive properties of these materials when exposed to high-energy ion beams is described. The past and future prospects for hybrid organic-on-inorganic semiconductor structures for use in electronic and photonic applications are also presented

  9. Elucidation of the substitution pattern of 9,10-anthraquinones through the chemical shifts of peri-hydroxyl protons

    DEFF Research Database (Denmark)

    Schripsema, Jan; Danigno, Denise

    1996-01-01

    In 9,10-anthraquinones the chemical shift of a peri-hydroxyl proton is affected by the substituents in the other benzenoid ring. These effects are additive. They are useful for the determination of substitution patterns and have been used to revise the structures of six previously reported...... anthraquinones containing methoxyl, hydroxyl, methylenedioxy and beta-methyl substituents. Because the chemical shifts of the other protons are hardly affected by substitutions in the other ring, the characteristic chemical shifts for a wide variety of substitution patterns could be derived....

  10. Reproducibility and Relative Validity of a Short Food Frequency Questionnaire in 9-10 Year-Old Children.

    Science.gov (United States)

    Saeedi, Pouya; Skeaff, Sheila A; Wong, Jyh Eiin; Skidmore, Paula M L

    2016-05-07

    The aim of this study was to assess the reproducibility and validity of a non-quantitative 28-item food frequency questionnaire (FFQ). Children aged 9-10 years (n = 50) from three schools in Dunedin, New Zealand, completed the FFQ twice and a four-day estimated food diary (4DEFD) over a two-week period. Intraclass correlation coefficients (ICC) and Spearman's correlation coefficients (SCC) were used to determine reproducibility and validity of the FFQ, respectively. Weekly intakes were estimated for each food item and aggregated into 23 food items/groups. More than half of the food items/groups (52.2%) had an ICC ≥0.5. The median SCC between FFQ administrations was 0.66 (ranging from 0.40 for processed meat to 0.82 for sweets and non-dairy drinks). Cross-classification analysis between the first FFQ and 4DEFD for ranking participants into thirds showed that breakfast cereals had the highest agreement (54.0%) and pasta the lowest (34.0%). In validity analyses, 70% of food items/groups had a SCC ≥0.3. Results indicate that the FFQ is a useful tool for ranking children according to food items/groups intake. The low respondent burden and relative simplicity of the FFQ makes it suitable for use in large cohort studies of 9-10 year-old children in New Zealand.

  11. Pulse radiolytic one-electron reduction of 2-hydroxy- and 2,6-dihydroxy-9,10-anthraquinones

    International Nuclear Information System (INIS)

    Pal, Haridas; Mukherjee, Tulsi; Mittal, J.P.

    1994-01-01

    The semiquinone free radicals produced by one-electron reduction of 2-hydroxy-9-10-anthraquinone (2HAQ) and 2,6-dihydroxy-9,10-anthraquinone (26DHAQ) in aqueous formate solution, water-isopropyl alcohol-acetone mixed solvent and isopropyl alcohol have been studied using the pulse radiolysis technique. The absorption characteristics, kinetic parameters of formation and decay, acid-base behaviour and redox characteristics of the semiquinones have been investigated and compared with the corresponding characteristics of a few intramolecularly hydro-bonded anthrasemiquinone derivatives. The non-hydrogen-bonded semiquinones show two pKsub(a) values (4.7 and 10.7 for 2HAQ and 5.4 and 8.7 for 26DHAQ, respectively) within the pH range 1-14, whereas other intramolecularly hydrogen-bonded semiquinones show only one pKsub(a). The one-electron reduction potential (E' 7 ) values for 2HAQ (-440 mV) and 26DHAQ (- 400 mV) are more negative than those of the intramolecularly hydrogen-bonded systems. (Author)

  12. Preparation of 14C-labeled 8,9-didehydro-6,8-dimethyl-2-methylthioergoline mesylate, a dopamine antagonist potentially useful in the treatment of schizophrenia

    International Nuclear Information System (INIS)

    Wheeler, W.J.

    1988-01-01

    We have prepared 14 C-labeled 8,9-didehydro-6,8-dimethyl-2-methyl-thioergoline mesylate (LY 170542), a dopamine antagonist potentially useful as an anti-psychotic. The 14 C-label was introduced via a novel application of the Wittig reaction on 1-(4'-toluene-sulfonyl)-8,9-didehydro-6-methyl-ergolin-8-one and subsequent reduction of 1-(4'-toluenesulfonyl)-17-[ 14 C]-lysergene by lithium/ammonia at -33 0 C. The 17-[ 14 C]-agroclavine thus prepared was converted into 17-[ 14 C]-LY 170542 by reaction with methanesulfenyl chloride/methanesulfonic acid. (author)

  13. Novel routes to 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines and 5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazines.

    Science.gov (United States)

    Katritzky, Alan R; Jain, Ritu; Xu, Yong-Jiang; Steel, Peter J

    2002-11-15

    Condensation reactions of benzotriazole and 2-(pyrrol-1-yl)-1-ethylamine (1) with formaldehyde and glutaric dialdehyde, respectively, afforded intermediates 2 and 6. Subsequent nucleophilic substitutions of the benzotriazole group in 2 and 6 with Grignard reagents, sodium cyanide, and sodium borohydride gave 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines 3a-e, 4, 5 and 5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazines 7a-c, 8, 9, respectively, in good yields.

  14. Isolable Triradical Trication of Hexaaza[16]paracyclophane with Embedded 9,10-Anthrylenes: A Frustrated Three-Spin System.

    Science.gov (United States)

    Kurata, Ryohei; Sakamaki, Daisuke; Uebe, Masashi; Kinoshita, Mariko; Iwanaga, Tetsuo; Matsumoto, Takashi; Ito, Akihiro

    2017-08-18

    A new derivative of hexaaza[1 6 ]paracyclophane in which p-phenylenes are alternately replaced by 9,10-anthrylenes was prepared to investigate the impact on overall π-conjugation as well as conformational change of the macrocycle. The charge and spin distribution for one-electron and three-electron oxidation of the macrocycle was elucidated by means of electrochemical, spectroelectrochemical, EPR spectroscopic, and SQUID magnetometric methods. In particular, the triradical trication was successfully isolated as an air-stable salt, and moreover, its structure was disclosed by X-ray analysis. The triradical trication was characterized as a spin-frustrated three-spin system with the antiferromagnetic exchange interaction (J/k B ≃ - 74 K).

  15. Mechanical properties of steel 8 CrMoNiNb 9 10 in dependence on the microstructural condition

    International Nuclear Information System (INIS)

    Fabritius, H.; Schnabel, E.

    1976-01-01

    Tension tests at room temperature to 600 0 C and creep-rupture tests at 500 to 600 0 C lasting up to about 75,000 h on two casts of steel 8 CrMoNiNb 9 10 with about 0.08% C, 0.3% Si, 0.7% Mn, 0.012% N, 0.005% Al, 2.34% Cr, 0.95% Mo, 0.8% Nb and 0.64% Ni in bainitic and ferritic microstructural condition. Influence of annealing at 650 to 800 0 C on the properties in the tension test. Influence of aging at 500 to 600 0 C lasting up to 30,000 h with and without mechanical stress on the properties in the tension test at aging temperature and on the toughness behaviour in the notched bar impact bend test at room temperature. (orig.) [de

  16. Efficient and stable single-dopant white OLEDs based on 9,10-bis (2-naphthyl) anthracene

    International Nuclear Information System (INIS)

    Tao Silu; Peng Zhaokuai; Zhang Xiaohong; Wu Shikang

    2006-01-01

    Efficient white organic light-emitting diodes (WOLEDs) are fabricated with a thin layer of 9,10-bis (2-naphthyl) anthracene (ADN) doped with Rubrene as the source of white emission. A device with the structure of ITO/NPB (70nm)/ADN: 0.5% Rubrene (30nm)/Alq 3 (50nm)/MgAg shows a maximum current efficiency of 3.7cd/A, with the CIE coordinates of x=0.33, y=0.43. The EL spectrum of the devices and the CIE coordinates remains almost the same when the voltage is increased from 10 to 15V and the current efficiency remains quite stable with the current density increased from 20 to 250mA/cm 2

  17. Novel derivatives of 9,10-anthraquinone are selective algicides against the musty-odor cyanobacterium Oscillatoria perornata.

    Science.gov (United States)

    Schrader, Kevin K; Nanayakkara, N P Dhammika; Tucker, Craig S; Rimando, Agnes M; Ganzera, Markus; Schaneberg, Brian T

    2003-09-01

    Musty "off-flavor" in pond-cultured channel catfish (Ictalurus punctatus) costs the catfish production industry in the United States at least 30 million US dollars annually. The cyanobacterium Oscillatoria perornata (Skuja) is credited with being the major cause of musty off-flavor in farm-raised catfish in Mississippi. The herbicides diuron and copper sulfate, currently used by catfish producers as algicides to help mitigate musty off-flavor problems, have several drawbacks, including broad-spectrum toxicity towards the entire phytoplankton community that can lead to water quality deterioration and subsequent fish death. By use of microtiter plate bioassays, a novel group of compounds derived from the natural compound 9,10-anthraquinone have been found to be much more selectively toxic towards O. perornata than diuron and copper sulfate. In efficacy studies using limnocorrals placed in catfish production ponds, application rates of 0.3 micro M (125 micro g/liter) of the most promising anthraquinone derivative, 2-[methylamino-N-(1'-methylethyl)]-9,10-anthraquinone monophosphate (anthraquinone-59), dramatically reduced the abundance of O. perornata and levels of 2-methylisoborneol, the musty compound produced by O. perornata. The abundance of green algae and diatoms increased dramatically 2 days after application of a 0.3 micro M concentration of anthraquinone-59 to pond water within the limnocorrals. The half-life of anthraquinone-59 in pond water was determined to be 19 h, making it much less persistent than diuron. Anthraquinone-59 appears to be promising for use as a selective algicide in catfish aquaculture.

  18. Novel Derivatives of 9,10-Anthraquinone Are Selective Algicides against the Musty-Odor Cyanobacterium Oscillatoria perornata

    Science.gov (United States)

    Schrader, Kevin K.; Dhammika Nanayakkara, N. P.; Tucker, Craig S.; Rimando, Agnes M.; Ganzera, Markus; Schaneberg, Brian T.

    2003-01-01

    Musty “off-flavor” in pond-cultured channel catfish (Ictalurus punctatus) costs the catfish production industry in the United States at least $30 million annually. The cyanobacterium Oscillatoria perornata (Skuja) is credited with being the major cause of musty off-flavor in farm-raised catfish in Mississippi. The herbicides diuron and copper sulfate, currently used by catfish producers as algicides to help mitigate musty off-flavor problems, have several drawbacks, including broad-spectrum toxicity towards the entire phytoplankton community that can lead to water quality deterioration and subsequent fish death. By use of microtiter plate bioassays, a novel group of compounds derived from the natural compound 9,10-anthraquinone have been found to be much more selectively toxic towards O. perornata than diuron and copper sulfate. In efficacy studies using limnocorrals placed in catfish production ponds, application rates of 0.3 μM (125 μg/liter) of the most promising anthraquinone derivative, 2-[methylamino-N-(1′-methylethyl)]-9,10-anthraquinone monophosphate (anthraquinone-59), dramatically reduced the abundance of O. perornata and levels of 2-methylisoborneol, the musty compound produced by O. perornata. The abundance of green algae and diatoms increased dramatically 2 days after application of a 0.3 μM concentration of anthraquinone-59 to pond water within the limnocorrals. The half-life of anthraquinone-59 in pond water was determined to be 19 h, making it much less persistent than diuron. Anthraquinone-59 appears to be promising for use as a selective algicide in catfish aquaculture. PMID:12957919

  19. 75 FR 38017 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-10 Series Airplanes, DC-9-30...

    Science.gov (United States)

    2010-07-01

    ... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-10 Series Airplanes, DC-9-30 Series... previously to all known U.S. owners and operators of the McDonnell Douglas Corporation airplanes identified... INFORMATION: On July 15, 2009, we issued AD 2009-15-16, which applies to all McDonnell Douglas Model DC-9-10...

  20. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy: 3, Energy, Engines, and the Industrial Revolution, Grades 8, 9.

    Science.gov (United States)

    Childs, Barbara; And Others

    This instructional unit for grades 8-9 combines science and social studies in a look at the broad social and economic upheavals that took place during the industrial revolution, giving special emphasis to the role of energy. The invention and development of the steam engine is highlighted in one lesson. Other lessons show how the industrial…

  1. Development of fuel cycles with new fuel with 8.9 mm external diameter for VVER-440. Preliminary assessment of operating efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Gagarinskiy, Alexey [National Research Centre ' ' Kurchatov Institute' ' , Moscow (Russian Federation)

    2017-09-15

    Since the introduction of VVERs-440, their fuel assemblies are subject to ongoing improvements. Until now, the basic structural parameters of fuel, such as rod diameter of 9.1 mm, have never changed. This paper focuses on computational estimates of basic neutronic parameters of the fuel cycle that involves assemblies consisting of fuel rods with diameter reduced to 8.9 mm.

  2. Detecção de locos de características quantitativas nos cromossomos 9, 10 e 11 de suínos Detection of quantitative trait loci on chromosomes 9, 10 and 11 of swines

    Directory of Open Access Journals (Sweden)

    Ana Paula Gomes Pinto

    2010-10-01

    Full Text Available Objetivou-se com este estudo mapear locos de características quantitativas (QTL nos cromossomos 9, 10 e 11 de suínos (Sus scrofa e associar seus efeitos em características de carcaça, cortes de carcaça, órgãos e vísceras, desempenho e qualidade de carne. Utilizaram-se amostras de DNA de animais pertencentes a uma população F2, oriunda do cruzamento entre machos da raça Piau e fêmeas Landrace õ Large White õ Pietrain. Um total de 13 locos microssatélites foi utilizado na construção dos mapas de ligação da população atual. As análises de associação foram feitas utilizando-se mapeamento de intervalo por regressão para detecção de QTL. Identificaram-se associações significativas, em nível cromossômico, entre regiões do cromossomo 9 e as características peso total do carré e peso do lombo. No cromossomo 10, foram detectados três QTL significativos para espessura de toucinho na linha dorso-lombar entre a última e a penúltima vértebra lombar, peso de pulmão e índice de vermelho e um QTL significativo, no nível genômico, para peso de fígado. No cromossomo 11, foi detectada apenas uma associação significativa, em nível cromossômico, relacionada à espessura de toucinho imediatamente após a última costela, a 6,5 cm da linha dorso-lombar. As informações dos QTL significativos encontrados são importantes para estudos futuros, como o mapeamento fino e a identificação de genes, que ajudem no melhor entendimento da fisiologia e das características de produção de suínos.The objective of this study was to map quantitative trait loci (QTL in chromosomes 9, 10 and 11 of swines (Sus scrofa and to associate their effects on traits of carcass, carcass cuts, organs and guts, performance and meat quality. Samples of DNA of animals from a F2 population originated from crosses between Piau breed males and Landrace õ Large White õ Pietrain females were used. A total of 13 microsatellite loci were used to build

  3. H2 EJECTION FROM POLYCYCLIC AROMATIC HYDROCARBONS: INFRARED MULTIPHOTON DISSOCIATION STUDY OF PROTONATED ACENAPHTHENE AND 9,10-DIHYDROPHENANTHRENE

    International Nuclear Information System (INIS)

    Szczepanski, Jan; Vala, Martin T.; Oomens, Jos; Steill, Jeffrey D.

    2011-01-01

    The infrared multiple-photon dissociation (IRMPD) spectra of protonated acenaphthene ([ACN+H] + ) and 9,10-dihydrophenanthrene ([DHP+H] + ) have been recorded using an infrared free electron laser after the compounds were protonated by electrospray ionization and trapped in a Fourier transform ion cyclotron mass spectrometer. In both compounds, the loss of two mass units is predominant. Density functional calculations (B3LYP/6-311++G(d,p)) of the infrared spectra of all possible protonated isomers of each species showed that the observed IRMPD spectra are best fit to the isomer with the largest proton affinity and lowest relative electronic energy. Potential energy surfaces of the most stable isomers of [ACN+H] + and [DHP+H] + have been calculated for H and H 2 loss. The lowest energy barriers are for loss of H 2 , with predicted energies 4.28 and 4.15 eV, respectively. After H 2 ejection, the adjacent aliphatic hydrogens migrate to the bare ejection site and stabilize the remaining fragment. Single H loss may occur from [ACN+H] + but the energy required is higher. No single H loss is predicted from [DHP+H] + , only H migration around the carbon skeleton. The vibrational bands in the parent closed-shell protonated polycyclic aromatic hydrocarbons are compared to bands observed from the interstellar medium.

  4. Electrical conductivity, optical properties and mechanical stability of 3, 4, 9, 10-perylenetetracarboxylic dianhidride based organic semiconductor

    Science.gov (United States)

    Pandey, Mayank; Joshi, Girish M.; Deshmukh, Kalim; Nath Ghosh, Narendra; Nambi Raj, N. Arunai

    2015-05-01

    The 3, 4, 9, 10-perylenetetracarboxylic dianhydride (PTCDA) doped polymer films were prepared with Polypyrrole (PPy) and Polyvinyl alcohol (PVA) polymers by solution-casting. The change in structure and chemical composition of samples was identified by XRD and FTIR respectively. The UV-visible spectroscopy demonstrates the optical characteristics and band gap properties of sample. The homogeneous morphology of sample for higher wt% of PTCDA was examined by atomic force microscopy (AFM). The differential scanning calorimetry (DSC) results demonstrate the decrease in melting temperature (Tm) and degree of crystallinity (χc%) of polymeric organic semiconductor. The mechanical property demonstrates the high tensile strength and improved plasticity nature. Impedance spectroscopy was evaluated to determine the conductivity response of polymeric organic semiconductor. The highest DC conductivity (2.08×10-3 S/m) was obtained for 10 wt% of PTCDA at 140 °C. The decrease in activation energy (Ea) represents the non-Debye process and was evaluated from the slope of ln σdc vs. 103/T plot.

  5. CLOSURE REPORT FOR CORRECTIVE ACTION UNIT 390: AREAS 9, 10, AND 12 SPILL SITES, NEVADA TEST SITE, NEVADA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-01

    Corrective Action Unit (CAU) 390 consists four Corrective Action Sites (CASs) located in Areas 9, 10, and 12 of the Nevada Test Site. The closure activities performed at the CASs include: (1) CAS 09-99-03, Wax, Paraffin: 2 cubic yards of drilling polymer was removed on June 20,2005, and transported to the Area 9 Landfill for disposal. (2) CAS 10-99-01, Epoxy Tar Spill: 2 cubic feet of asphalt waste was removed on June 20,2005, and transported to the Area 9 Landfill for disposal. (3) CAS 10-99-03, Tar Spills: 3 cubic yards of deteriorated asphalt waste was removed on June 20,2005, and transported to the Area 9 Landfill for disposal. (4) CAS 12-25-03, Oil Stains (2); Container: Approximately 16 ounces of used oil were removed from ventilation equipment on June 28,2005, and recycled. One CAS 10-22-19, Drums, Stains, was originally part of CAU 390 but was transferred out of CAU 390 and into CAU 550, Drums, Batteries, and Lead Materials. The transfer was approved by the Nevada Division of Environmental Protection on August 19,2005, and a copy of the approval letter is included in Appendix D of this report.

  6. Designing Efficient Solar-Thermal Fuels with [n.n](9,10)Anthracene Cyclophanes: A Theoretical Perspective.

    Science.gov (United States)

    Ganguly, Gaurab; Sultana, Munia; Paul, Ankan

    2018-01-18

    Molecular solar thermal storage (MOST) systems have been largely limited to three classes of molecular motifs: azo-benzene, norbornadiene, and transition metal based fulvalene-tetracarbonyl systems. Photodimerization of anthracene has been known for a century; however, this photoprocess has not been successfully exploited for MOST purposes due to its poor energy storage. Using well-calibrated theoretical methods on a series of [n.n](9,10)bis-anthracene cyclophanes, we have exposed that they can store solar energy into chemical bonds and can release in the form of heat energy on demand under mild conditions. The storage is mainly attributed to the strain in the rings formed by the alkyl linkers upon photoexcitation. Our results demonstrate that the gravimetric energy storage density for longer alkyl-chain linkers (n > 3) are comparable to those for the best-known candidates; however, it lacks some of the deleterious attributes of known systems, thus making the proposed molecules desirable targets for MOST applications.

  7. Spectrophotometric determination of ruthenium (III) and rhodium (III) with 9,10-phenanthrenequinone monoxime after extraction into molten naphthalene

    International Nuclear Information System (INIS)

    Wasey, A.; Bansal, R.K.; Puri, B.K.; Satake, Masatada.

    1983-01-01

    9,10-Phenanthrenequinone monoxime has been used as a reagent for the spectrophotometric determination of ruthenium(III) and rhodium(III) after extraction into molten naphthalene. The extracted mixture of the metal complex and naphthalene was dissolved in chloroform and ruthenium and rhodium were determined spectrophotometrically. Beer's law holds in the concentration range of 0.2-4.1 μg/cm 3 for ruthenium and 0.3-5.3 μg/cm 3 for rhodium in 10 cm 3 of the final solution. The molar absorptivities and Sandell sensitivities are calculated to be 9.70 x 10 3 l mol -1 cm -1 and 0.01 μg/cmsup(2 ) (660 nm) for ruthenium and 1.13 x 10 4 l mol -1 cm -1 and 0.009 μg/cm 2 (410 nm) for rhodium respectively. Aliquots containing 2.0 μg of ruthenium and 4.1 μg of rhodium give mean absorbances of 0.192 and 0.451 with standard deviations of 0.0017 and 0.0039, respectively. Interference of various ions has been studied and the method has been applied to the determination of ruthenium and rhodium in various synthetic mixtures. This procedure is also applied to the simultaneous determination of ruthenium and rhodium present together in a solution. (author)

  8. SERS investigations on orientation of 2-bromo-3-methyl-1,4-dimethoxy-9,10-anthraquinone on silver nanoparticles.

    Science.gov (United States)

    Anuratha, M; Jawahar, A; Umadevi, M; Sathe, V G; Vanelle, P; Terme, T; Khoumeri, O; Meenakumari, V; Milton Franklin Benial, A

    2015-01-01

    Silver nanoparticles (Ag NPs) were prepared by solution combustion method with urea as fuel. Silver nanoparticles were characterized by UV-visible spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. Surface-enhanced Raman scattering (SERS) of 2-bromo-3-methyl-1,4-dimethoxy-9,10-anthraquinone (BMDMAQ) adsorbed on silver nanoparticles was investigated. The orientation of BMDMAQ on silver nanoparticles was inferred from nRs and SERS spectral features. Density functional theory (DFT) calculation was also performed to study the theoretical performance. The observed spectral features such as the high intensity of C-H out-of-plane bending mode and ring C-C stretching mode revealed that BMDMAQ adsorbed on silver surface through 'stand-on' orientation. Anthraquinone (AQ) derivatives have wide biomedical application which includes laxatives, antimalarials and antineoplastics used in the treatment of cancer. This present study would help to identify the interaction of drug molecules with DNA. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. 9,10-Anthraquinone hinders β-aggregation: How does a small molecule interfere with Aβ-peptide amyloid fibrillation?

    Science.gov (United States)

    Convertino, Marino; Pellarin, Riccardo; Catto, Marco; Carotti, Angelo; Caflisch, Amedeo

    2009-01-01

    Amyloid aggregation is linked to a number of neurodegenerative syndromes, the most prevalent one being Alzheimer's disease. In this pathology, the β-amyloid peptides (Aβ) aggregate into oligomers, protofibrils, and fibrils and eventually into plaques, which constitute the characteristic hallmark of Alzheimer's disease. Several low-molecular-weight compounds able to impair the Aβ aggregation process have been recently discovered; yet, a detailed description of their interactions with oligomers and fibrils is hitherto missing. Here, molecular dynamics simulations are used to investigate the influence of two relatively similar tricyclic, planar compounds, that is, 9, 10-anthraquinone (AQ) and anthracene (AC), on the early phase of the aggregation of the Aβ heptapeptide segment H14QKLVFF20, the hydrophobic stretch that promotes the Aβ self-assembly. The simulations show that AQ interferes with β-sheet formation more than AC. In particular, AQ intercalates into the β-sheet because polar interactions between the compound and the peptide backbone destabilize the interstrand hydrogen bonds, thereby favoring disorder. The thioflavin T-binding assay indicates that AQ, but not AC, sensibly reduces the amount of aggregated Aβ1–40 peptide. Taken together, the in silico and in vitro results provide evidence that structural perturbations by AQ can remarkably affect ordered oligomerization. Moreover, the simulations shed light at the atomic level on the interactions between AQ and Aβ oligomers, providing useful insights for the design of small-molecule inhibitors of aggregation with therapeutic potential in Alzheimer's disease. PMID:19309732

  10. Structural and Optical Properties of Nanocrystalline 3,4,9,10-Perylene-Tetracarboxylic-Diimide Thin Film

    Directory of Open Access Journals (Sweden)

    M. M. El-Nahhas

    2012-01-01

    Full Text Available Thin films of nanocrystalline 3,4,9,10-perylene-tetracarboxylic-diimide (PTCDI were prepared on quartz substrates by thermal evaporation technique. The structural properties were identified by transmission electron microscopy (TEM and the X-ray diffraction (XRD. The optical properties for the films were investigated using spectrophotometric measurements of the transmittance and reflectance at normal incidence of light in the wavelength range from 200 to 2500 nm. The optical constants (refractive index n and absorption index k were calculated and found to be independent on the film thickness in the measured film thickness range 117–163 nm. The dispersion energy (Ed, the oscillator energy (Eo, and the high-frequency dielectric constant ε∞ were obtained. The energy band model was applied, and the types of the optical transitions responsible for optical absorption were found to be indirect allowed transition. The onset and optical energy gaps were calculated, and the obtained results were also discussed.

  11. 9,10-Anthraquinone deposit in tea plantation might be one of the reasons for contamination in tea.

    Science.gov (United States)

    Wang, Xuan; Zhou, Li; Luo, Fengjian; Zhang, Xinzhong; Sun, Hezhi; Yang, Mei; Lou, Zhengyun; Chen, Zongmao

    2018-04-01

    9,10-Anthraquinone (AQ) was a new contaminant, with unknown sources, occurred globally in tea. European Union (EU) fixed the maximum residue limit (MRL) of 0.02mg/kg. The pollution source of AQ in tea was traced from the view of AQ deposit on tea crop by simulation. The possible contamination pathway and main factors to decrease AQ were explored in tea cultivation- tea manufacture- tea infusion, on the basis of AQ analytical methods by using solvent extraction and gas chromatography-tandem mass spectrometry (GC-MS/MS) quantification. 58.8-84.6% of AQ degraded in tea processing, and drying played a key role to reduce the AQ contamination. Certain concentration of AQ deposited on tea shoots could resulted in AQ beyond the MRL of 0.02mg/kg in tea. AQ leaching into tea brew (about 10%) could lead to the possible health risk. AQ deposit on tea crop during the tea cultivation might cause the AQ contamination in tea. Copyright © 2017. Published by Elsevier Ltd.

  12. Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10

    Energy Technology Data Exchange (ETDEWEB)

    Matsunaga, Toshiyuki, E-mail: matsunagat@gifu-pu.ac.jp [Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196 (Japan); Morikawa, Yoshifumi; Haga, Mariko; Endo, Satoshi [Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196 (Japan); Soda, Midori; Yamamura, Keiko [Laboratory of Clinical Pharmacy, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650 (Japan); El-Kabbani, Ossama [Monash Institute of Pharmaceutical Sciences, Monash University, Victoria 3052 (Australia); Tajima, Kazuo [Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa 920-1181 (Japan); Ikari, Akira [Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196 (Japan); Hara, Akira [Faculty of Engineering, Gifu University, Gifu 501-1193 (Japan)

    2014-07-15

    Inhalation of 9,10-phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust, exerts fatal damage against a variety of cells involved in respiratory function. Here, we show that treatment with high concentrations of 9,10-PQ evokes apoptosis of lung cancer A549 cells through production of reactive oxygen species (ROS). In contrast, 9,10-PQ at its concentrations of 2 and 5 μM elevated the potentials for proliferation, invasion, metastasis and tumorigenesis, all of which were almost completely inhibited by addition of an antioxidant N-acetyl-L-cysteine, inferring a crucial role of ROS in the overgrowth and malignant progression of lung cancer cells. Comparison of mRNA expression levels of six aldo-keto reductases (AKRs) in the 9,10-PQ-treated cells advocated up-regulation of AKR1B10 as a major cause contributing to the lung cancer malignancy. In support of this, the elevation of invasive, metastatic and tumorigenic activities in the 9,10-PQ-treated cells was significantly abolished by the addition of a selective AKR1B10 inhibitor oleanolic acid. Intriguingly, zymographic and real-time PCR analyses revealed remarkable increases in secretion and expression, respectively, of matrix metalloproteinase 2 during the 9,10-PQ treatment, and suggested that the AKR1B10 up-regulation and resultant activation of mitogen-activated protein kinase cascade are predominant mechanisms underlying the metalloproteinase induction. In addition, HPLC analysis and cytochrome c reduction assay in in vitro 9,10-PQ reduction by AKR1B10 demonstrated that the enzyme catalyzes redox-cycling of this quinone, by which ROS are produced. Collectively, these results suggest that AKR1B10 is a key regulator involved in overgrowth and malignant progression of the lung cancer cells through ROS production due to 9,10-PQ redox-cycling. - Highlights: • 9,10-PQ promotes invasion, metastasis and tumorigenicity in lung cancer cells. • The 9,10-PQ-elicited promotion is possibly due to AKR1B10 up

  13. Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10

    International Nuclear Information System (INIS)

    Matsunaga, Toshiyuki; Morikawa, Yoshifumi; Haga, Mariko; Endo, Satoshi; Soda, Midori; Yamamura, Keiko; El-Kabbani, Ossama; Tajima, Kazuo; Ikari, Akira; Hara, Akira

    2014-01-01

    Inhalation of 9,10-phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust, exerts fatal damage against a variety of cells involved in respiratory function. Here, we show that treatment with high concentrations of 9,10-PQ evokes apoptosis of lung cancer A549 cells through production of reactive oxygen species (ROS). In contrast, 9,10-PQ at its concentrations of 2 and 5 μM elevated the potentials for proliferation, invasion, metastasis and tumorigenesis, all of which were almost completely inhibited by addition of an antioxidant N-acetyl-L-cysteine, inferring a crucial role of ROS in the overgrowth and malignant progression of lung cancer cells. Comparison of mRNA expression levels of six aldo-keto reductases (AKRs) in the 9,10-PQ-treated cells advocated up-regulation of AKR1B10 as a major cause contributing to the lung cancer malignancy. In support of this, the elevation of invasive, metastatic and tumorigenic activities in the 9,10-PQ-treated cells was significantly abolished by the addition of a selective AKR1B10 inhibitor oleanolic acid. Intriguingly, zymographic and real-time PCR analyses revealed remarkable increases in secretion and expression, respectively, of matrix metalloproteinase 2 during the 9,10-PQ treatment, and suggested that the AKR1B10 up-regulation and resultant activation of mitogen-activated protein kinase cascade are predominant mechanisms underlying the metalloproteinase induction. In addition, HPLC analysis and cytochrome c reduction assay in in vitro 9,10-PQ reduction by AKR1B10 demonstrated that the enzyme catalyzes redox-cycling of this quinone, by which ROS are produced. Collectively, these results suggest that AKR1B10 is a key regulator involved in overgrowth and malignant progression of the lung cancer cells through ROS production due to 9,10-PQ redox-cycling. - Highlights: • 9,10-PQ promotes invasion, metastasis and tumorigenicity in lung cancer cells. • The 9,10-PQ-elicited promotion is possibly due to AKR1B10 up

  14. Chameleonic reactivity of vicinal diazonium salt of acetylenyl-9,10-anthraquinones: synthetic application toward two heterocyclic targets.

    Science.gov (United States)

    Stepanov, A A; Gornostaev, L M; Vasilevsky, S F; Arnold, E V; Mamatyuk, V I; Fadeev, D S; Gold, B; Alabugin, I V

    2011-11-04

    The nature of products in the diazotization of 1-amino-2-acetylenyl-9,10-anthraquinones strongly depends on the nature of substituents at both the alkyne and at the anthraquinone core. Donor substitution (NHAr, OH) at the fourth position stabilizes the diazonium salt at C1, decelerating electrophilic cyclization at the arylethynyl substituent at C2. This effect allows the replacement of the diazonium with azide group and subsequent closure into isoxazole ring with preservation of the alkyne. In contrast, electrophilic 5-exo-dig cyclizations to condensed pyrazoles is observed for the combination of donor substituents at the aryl alkyne moiety and an OAc substituent at C4. The latter process provides a new synthetic route to 3-ethynyl-[1,9-cd]isoxazol-6-ones that are difficult to access otherwise. DFT calculations suggest that donor substituents have only a minor effect on alkyne and diazonium polarization in the reactant but provide specific transition state stabilization by stabilizing the incipient vinyl cation. This analysis provides the first computational data on electrophilic 5-exo-dig cyclization in its parent form and the nucleophile-promoted version. This cyclization is a relatively fast but endothermic process that is rendered thermodynamically feasible by the enol-keto tautomerization with concomitant aromatization in the five-membered heteroaromatic ring. Computations suggest that the importance of nucleophilic assistance in the transition state for a relatively weak nucleophile such as water is minor because the energy gain due to the Lewis base coordination to the carbocationic center is more than compensated for by the unfavorable entropic term for the bimolecular proces.

  15. Contribution of hydrophobic effect to the sorption of phenanthrene, 9-phenanthrol and 9, 10-phenanthrenequinone on carbon nanotubes.

    Science.gov (United States)

    Peng, Hongbo; Zhang, Di; Pan, Bo; Peng, Jinhui

    2017-02-01

    Polycyclic aromatic hydrocarbons (PAHs), with diverse sources and acute toxicity, are categorized as priority pollutants. Previous studies have stated that the hydrophobic effect controls PAH sorption, but no study has been conducted to quantify the exact contribution of the hydrophobic effect. Considering the well-defined structure of carbon nanotubes and their stable chemical composition in organic solvents, three multi-walled carbon nanotubes (MWCNTs) were selected as a model adsorbent. Phenanthrene (PHE) and its degradation intermediates 9-phenanthrol (PTR) and 9, 10-phenanthrenequinone (PQN) were used as model adsorbates. To quantify the contribution of the hydrophobic effect for these three chemicals, the effect of organic solvent (methanol and hexadecane) was investigated. Adsorption isotherms for PHE, PTR and PQN were well fitted by the Freundlich isotherm model. A positive relationship between adsorption affinities of these three chemicals and specific surface area (SSA) was observed in hexadecane but not in water or methanol. Other factors should be included other than SSA. Adsorption of PQN on MWCNTs with oxygen functional groups was higher than that on pristine MWCNTs due to π-π EDA interactions. The contribution of hydrophobic effect was 50%-85% for PHE, suggesting that hydrophobic effect was the predominant mechanism. This contribution was lower than 30% for PTR/PQN on functionalized MWCNTs. Hydrogen bonds control the adsorption of PTR, and π-π bonding interactions control PQN sorption after screening out the hydrophobic effect in hexadecane. Hydrophobic effect is the control mechanism for nonpolar chemicals, while functional groups of CNTs and solvent types control the adsorption of polar compounds. Extended work on quantifying the relationship between chemical structure and the contribution of the hydrophobic effect will provide a useful technique for PAH fate modeling. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Baseline coastal oblique aerial photographs collected from Calcasieu Lake, Louisiana, to Brownsville, Texas, September 9-10, 2008

    Science.gov (United States)

    Morgan, Karen L. M.; Karen A. Westphal,

    2016-04-28

    The U.S. Geological Survey (USGS), as part of the National Assessment of Coastal Change Hazards project, conducts baseline and storm-response photography missions to document and understand the changes in vulnerability of the Nation's coasts to extreme storms (Morgan, 2009). On September 9-10, 2008, the USGS conducted an oblique aerial photographic survey from Calcasieu Lake, Louisiana, to Brownsville, Texas, aboard a Cessna C-210 (aircraft) at an altitude of 500 feet (ft) and approximately 1,000 ft offshore. This mission was flown to collect baseline data for assessing incremental changes of the beach and nearshore area, and the data can be used in the assessment of future coastal change.The photographs provided in this report are Joint Photographic Experts Group (JPEG) images. ExifTool was used to add the following to the header of each photo: time of collection, Global Positioning System (GPS) latitude, GPS longitude, keywords, credit, artist (photographer), caption, copyright, and contact information. The photograph locations are an estimate of the position of the aircraft at the time the photograph was taken and do not indicate the location of any feature in the images (see the Navigation Data page). These photographs document the state of the barrier islands and other coastal features at the time of the survey. Pages containing thumbnail images of the photographs, referred to as contact sheets, were created in 5-minute segments of flight time. These segments can be found on the Photos and Maps page. Photographs can be opened directly with any JPEG-compatible image viewer by clicking on a thumbnail on the contact sheet.In addition to the photographs, a Google Earth Keyhole Markup Language (KML) file is provided and can be used to view the images by clicking on the marker and then clicking on either the thumbnail or the link above the thumbnail. The KML file was created using the photographic navigation files. The KML file can be found in the kml folder.

  17. Structure of steel 8 CrMoNiNb 9 10 and its variations in long-term thermal stress

    International Nuclear Information System (INIS)

    Fabritius, H.; Schnabel, E.

    1976-01-01

    On four casts of steel 8 CrMoNiNb 9 10 with about 0.06% C, 0.25; Si, 0.7% Mn, 0.012% N, 0.002 to 0.020% Al, 2.25% Cr, 0.94% Mo, 0.63 to 0.91% Nb and 0.67% Ni, transformation behaviour and structural changes during long-time annealing at 500 to 750 degC lasting up to 30,000 h were studied in unformed condition and after previous cold forming. The carbon content was largely bound in form of primary niobium carbonitrides so that during quenching and tempering low-carbon bainite was formed, or at very slow cooling a ferritic structure without pearlite. Martensite occurred only after fast cooling from temperatures above 1200 degC. Bainite exhibited a very high dislocation density and a large number of coherent niobium carbonitrides. During tempering, the precipitates overaged, and the dislocations started to arrange themselves to subgrain boundaries. Hardness and strength in quenched and tempered condition were essentially governed by dislocation density and size of subgrains. In the whole range of bainite transformation, they are only slightly dependent upon the cooling rate and hence upon the dimensions of the products. The structural changes which occurred in bainitic material during long-time aging and led to a ferritic structure in the final state were interpreted as recovery and recrystallization. In unformed and slightly formed material recrystallization led to a very coarse-grained structure. In highly formed material a very fine-grained structure was achieved by recrystallization. By a high degree of cold forming the recrystallization process was considerably promoted. With an annealing time of 10 5 h, no recrystallization is to be expected for unformed specimens of the studied cast up to 580 degC, but above 650 degC complete recrystallization. (author)

  18. Metal complexes with 1,5- and 1,8-dihydroxy-9,10-anthraquinones: electronic absorption spectra and structure of ligands

    International Nuclear Information System (INIS)

    Fajn, V.Ya.; Zajtsev, B.E.; Ryabov, M.A.

    2004-01-01

    By spectrophotometric, quantum-chemical, and correlation methods it is determined that in complexes of metals (Nd, Pr, Sm, Th, UO 2 2+ , V) with 1,5-dihydroxy-9,10-anthraquinone ligand could be in 7 excited states differing not only by ionization degree but primary contribution of tautomeric 9,10-, 1,10-, and 1,5-anthraquinoid structures. On all known complexes with 1,8-dihydroxy-9,10-anthraquinone containing once ionized ligand the last has 1,10-anthraquinoid structure; for complexes containing twofold ionized ligand 9,10-anthraquinoid structure of ligand is the most characteristic. Known complexes are classified in accordance with structure of ligands [ru

  19. Effect of hydrostatic pressure, temperature, and solvent on the rate of the Diels-Alder reaction between 9,10-anthracenedimethanol and maleic anhydride

    Science.gov (United States)

    Kiselev, V. D.; Kornilov, D. A.; Anikin, O. V.; Latypova, L. I.; Konovalov, A. I.

    2017-03-01

    The rate of the reaction between 9,10-anthracenedimethanol and maleic anhydride in 1,4-dioxane, acetonitrile, trichloromethane, and toluene is studied at 25, 35, 45°C in the pressure range of 1-1772 bar. The rate constants, enthalpies, entropies and activation volumes are determined. It is shown that the rate of reaction with 9,10-anthracenedimethanol is approximately one order of magnitude higher than with 9-anthracenemethanol.

  20. Association of alkali and alkaline earth metal cations with radical-anions of 9-fluorenone and 9.10-anthraquinone in dimethyl formamide medium

    International Nuclear Information System (INIS)

    Karpinets, A.P.; Bezuglyj, V.D.; Svetlichnaya, T.M.

    1988-01-01

    The polarographic method is used to estimate the stability of associates formed in dimethyl formamide by the products of one-electron reduction of 9-fluorenone and 9.10-anthraquinone with cations of alkali and alkali earth metals. It is shown that the strength of 9-fluorenone and 9.10-anthraquinone radical anion associates studied increases with cation charge increase and decrease of its crystallographic radius

  1. Association between diet and physical activity and sedentary behaviours in 9-10-year-old British White children.

    Science.gov (United States)

    Vissers, P A J; Jones, A P; van Sluijs, E M F; Jennings, A; Welch, A; Cassidy, A; Griffin, S J

    2013-03-01

    To examine the association between diet and physical activity and sedentary behaviours in 9-10-year-old children. A cross-sectional study using data from the SPEEDY (Sport, Physical activity and Eating behaviour: Environmental Determinants in Young People) study undertaken in Norfolk, UK. Data from 4-day food diaries and 7 days of accelerometery were matched on concurrent days. Time spent in moderate-to-vigorous physical activity (MVPA), time spent in sedentary behaviour and various measures of dietary intake were collected. Covariates included age, sex, weight status, family socio-economic status, and energy intake reporting quality. Multivariable regression models, adjusted for clustering of children by school and stratified by sex, were fitted to examine the associations between dietary measures and physical activity and sedentary outcomes. In total, 1317 children (584 boys and 733 girls) provided concurrent data. Boys in the highest quartile of energy percentage from protein spent approximately 6 min [95% confidence interval (CI) 0-12] less in MVPA compared with boys in the lowest quartile. Those in the highest quartiles of fruit and vegetable intake and fruit juice intake had respective average activity counts per minute that were 56 above (95% CI 8-105) and 48 below (95% CI 2-95) those in the lowest quartiles, whilst those in the highest quartile of fizzy drink consumption spent approximately 7 min (95% CI 2-13) more in MVPA and approximately 14 min (95% CI 5-24 min) less in sedentary behaviour. Boys in the highest quartile of savoury snack consumption spent approximately 8 min (95% CI 2-13 min) more in MVPA per day, and approximately 12 min (95% CI 2-23) less in sedentary behaviour. No significant associations were apparent among girls. Few associations were detected, and the directions of those that were apparent were mainly counterintuitive. The extent to which this reflects a true lack of association or is associated with the measurement methods used for

  2. Pet ownership, dog types and attachment to pets in 9-10 year old children in Liverpool, UK.

    Science.gov (United States)

    Westgarth, Carri; Boddy, Lynne M; Stratton, Gareth; German, Alexander J; Gaskell, Rosalind M; Coyne, Karen P; Bundred, Peter; McCune, Sandra; Dawson, Susan

    2013-05-13

    Little is known about ethnic, cultural and socioeconomic differences in childhood ownership and attitudes to pets. The objective of this study was to describe the factors associated with living with different pet types, as well as factors that may influence the intensity of relationship or 'attachment' that children have to their pet. Data were collected using a survey of 1021 9-10 year old primary school children in a deprived area of the city of Liverpool, UK. Dogs were the most common pet owned, most common 'favourite' pet, and species most attached to. Twenty-seven percent of dog-owning children (10% of all children surveyed) reported living with a 'Bull Breed' dog (which includes Pit Bulls and Staffordshire Bull Terriers), and the most popular dog breed owned was the Staffordshire Bull Terrier. Multivariable regression modelling identified a number of variables associated with ownership of different pets and the strength of attachment to the child's favourite pet. Girls were more likely to own most pet types, but were no more or less attached to their favourite pet than boys. Children of white ethnicity were more likely to own dogs, rodents and 'other' pets but were no more or less attached to their pets than children of non-white ethnicity. Single and youngest children were no more or less likely to own pets than those with younger brothers and sisters, but they showed greater attachment to their pets. Children that owned dogs lived in more deprived areas than those without dogs, and deprivation increased with number of dogs owned. 'Pit Bull or cross' and 'Bull Breed' dogs were more likely to be found in more deprived areas than other dog types. Non-whites were also more likely to report owning a 'Pit Bull or cross' than Whites. Gender, ethnicity and socioeconomic status were associated with pet ownership, and sibling status with level of attachment to the pet. These are important to consider when conducting research into the health benefits and risks of the

  3. Dual effects of N-acetyl-L-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity

    International Nuclear Information System (INIS)

    Toyooka, Tatsushi; Shinmen, Takuya; Aarts, Jac M.M.J.G.; Ibuki, Yuko

    2012-01-01

    A typical antioxidant, N-acetyl-L-cysteine (NAC) generally protects cells from oxidative damage induced by reactive oxygen species (ROS). 9,10-Phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust particles, produces ROS in redox cycling following two-electron reduction by NAD(P)H:quinone oxidoreductase 1 (NQO1), which has been considered as a cause of its cyto- and genotoxicity. In this study, we show that NAC unexpectedly augments the toxicity of 9,10-PQ in cells with low NQO1 activity. In four human skin cell lines, the expression and the activity of NQO1 were lower than in human adenocarcinoma cell lines, A549 and MCF7. In the skin cells, the cytotoxicity of 9,10-PQ was significantly enhanced by addition of NAC. The formation of DNA double strand breaks accompanying phosphorylation of histone H2AX, was also remarkably augmented. On the other hand, the cyto- and genotoxicity were suppressed by addition of NAC in the adenocarcinoma cells. Two contrasting experiments: overexpression of NQO1 in CHO-K1 cells which originally expressed low NQO1 levels, and knock‐down of NQO1 in the adenocarcinoma cell line A549 by transfection of RNAi, also showed that NAC suppressed 9,10-PQ-induced toxicity in cell lines expressing high NQO1 activity and enhanced it in cell lines with low NQO1 activity. The results suggested that dual effects of NAC on the cyto- and genotoxicity of 9,10-PQ were dependent on tissue-specific NQO1 activity. -- Highlights: ► NAC augmented the cytotoxicity of 9,10-PQ in skin cell lines. ► 9,10-PQ-induced DSBs accompanying γ-H2AX were also augmented by NAC. ► NAC suppressed the cyto- and genotoxicity of 9,10-PQ in adenocarcinoma cell lines. ► The dual effects of NAC on toxicity of 9,10-PQ were dependent on NQO1 activity.

  4. 9,10-phenanthrenesemiquinone radical complexes of ruthenium(III), osmium(III) and rhodium(III) and redox series.

    Science.gov (United States)

    Biswas, Manas Kumar; Patra, Sarat Chandra; Maity, Amarendra Nath; Ke, Shyue-Chu; Weyhermüller, Thomas; Ghosh, Prasanta

    2013-05-14

    Reactions of 9,10-phenanthrenequinone (PQ) in toluene with [M(II)(PPh3)3X2] at 298 K afford green complexes, trans-[M(PQ)(PPh3)2X2] (M = Ru, X = Cl, 1; M = Os, X = Br, 2) in moderate yields. Reaction of anhydrous RhCl3 with PQ and PPh3 in boiling ethanol affords the dark brown paramagnetic complex, cis-[Rh(PQ)(PPh3)2Cl2] (3) in good yields. Diffusion of iodine solution in n-hexane to the trans-[Os(PQ) (PPh3)2(CO)(Br)] solution in CH2Cl2 generates the crystals of trans-[Os(PQ)(PPh3)2(CO)(Br)](+)I3(-), (4(+))I3(-)), in lower yields. Single crystal X-ray structure determinations of 1·2toluene, 2·CH2Cl2 and 4(+)I3(-), UV-vis/NIR absorption spectra, EPR spectra of 3, electrochemical activities and DFT calculations on 1, 2, trans-[Ru(PQ)(PMe3)2Cl2] (1Me), trans-[Os(PQ)(PMe3)2Br2] (2Me), cis-[Rh(PQ)(PMe3)2Cl2] (3Me) and their oxidized and reduced analogues including trans-[Os(PQ)(PMe3)2(CO)(Br)](+) (4Me(+)) substantiated that 1-3 are the 9,10-phenanthrenesemiquinone radical (PQ(˙-)) complexes of ruthenium(III), osmium(III) and rhodium(III) and are defined as trans/cis-[M(III)(PQ(˙-))(PPh3)2X2] with a minor contribution of the resonance form trans/cis-[M(II)(PQ)(PPh3)2X2]. Two comparatively longer C-O (1.286(4) Å) and the shorter C-C lengths (1.415(7) Å) of the OO-chelate of 1·2toluene and 2·CH2Cl2 and the isotropic fluid solution EPR signal at g = 1.999 of 3 are consistent with the existence of the reduced PQ(˙-) ligand in 1-3 complexes. Anisotropic EPR spectra of the frozen glasses (g11 = g22 = 2.0046 and g33 = 1.9874) and solids (g11 = g22 = 2.005 and g33 = 1.987) instigate the contribution of the resonance form, cis-[Rh(II)(PQ)(PPh3)2Cl2] in 3. DFT calculations established that the closed shell singlet (CSS) solutions of 1Me and 2Me are unstable due to open shell singlet (OSS) perturbation. However, the broken symmetry (BS) (1,1) Ms = 0 solutions of 1Me and 2Me are respectively 22.6 and 24.2 kJ mole(-1) lower in energy and reproduced the experimental bond

  5. Genome sequence of Prevotella intermedia SUNY aB G8-9K-3, a biofilm forming strain with drug-resistance.

    Science.gov (United States)

    Moon, Ji-Hoi; Kim, Minjung; Lee, Jae-Hyung

    Prevotella intermedia has long been known to be as the principal etiologic agent of periodontal diseases and associated with various systemic diseases. Previous studies showed that the intra-species difference exists in capacity of biofilm formation, antibiotic resistance, and serological reaction among P. intermedia strains. Here we report the genome sequence of P. intermedia SUNY aB G8-9K-3 (designated ATCC49046) that displays a relatively high antimicrobial resistant and biofilm-forming capacity. Genome sequencing information provides important clues in understanding the genetic bases of phenotypic differences among P. intermedia strains. Copyright © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  6. The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice.

    Science.gov (United States)

    Waumans, Yannick; Vliegen, Gwendolyn; Maes, Lynn; Rombouts, Miche; Declerck, Ken; Van Der Veken, Pieter; Vanden Berghe, Wim; De Meyer, Guido R Y; Schrijvers, Dorien; De Meester, Ingrid

    2016-02-01

    Atherosclerosis remains the leading cause of death in Western countries. Dipeptidyl peptidase (DPP) 4 has emerged as a novel target for the prevention and treatment of atherosclerosis. Family members DPP8 and 9 are abundantly present in macrophage-rich regions of atherosclerotic plaques, and DPP9 inhibition attenuates activation of human M1 macrophages in vitro. Studying this family in a mouse model for atherosclerosis would greatly advance our knowledge regarding their potential as therapeutic targets. We found that DPP4 is downregulated during mouse monocyte-to-macrophage differentiation. DPP8 and 9 expression seems relatively low in mouse monocytes and macrophages. Viability of primary mouse macrophages is unaffected by DPP4 or DPP8/9 inhibition. Importantly, DPP8/9 inhibition attenuates macrophage activation as IL-6 secretion is significantly decreased. Mouse macrophages respond similarly to DPP inhibition, compared to human macrophages. This shows that the mouse could become a valid model species for the study of DPPs as therapeutic targets in atherosclerosis.

  7. A cluster-randomized controlled trial to reduce sedentary behavior and promote physical activity and health of 8-9 year olds: The Transform-Us! Study

    Directory of Open Access Journals (Sweden)

    Ball Kylie

    2011-10-01

    Full Text Available Abstract Background Physical activity (PA is associated with positive cardio-metabolic health and emerging evidence suggests sedentary behavior (SB may be detrimental to children's health independent of PA. The primary aim of the Transform-Us! study is to determine whether an 18-month, behavioral and environmental intervention in the school and family settings results in higher levels of PA and lower rates of SB among 8-9 year old children compared with usual practice (post-intervention and 12-months follow-up. The secondary aims are to determine the independent and combined effects of PA and SB on children's cardio-metabolic health risk factors; identify the factors that mediate the success of the intervention; and determine whether the intervention is cost-effective. Methods/design A four-arm cluster-randomized controlled trial (RCT with a 2 × 2 factorial design, with schools as the unit of randomization. Twenty schools will be allocated to one of four intervention groups, sedentary behavior (SB-I, physical activity (PA-I, combined SB and PA (SB+PA-I or current practice control (C, which will be evaluated among approximately 600 children aged 8-9 years in school year 3 living in Melbourne, Australia. All children in year 3 at intervention schools in 2010 (8-9 years will receive the intervention over an 18-month period with a maintenance 'booster' delivered in 2012 and children at all schools will be invited to participate in the evaluation assessments. To maximize the sample and to capture new students arriving at intervention and control schools, recruitment will be on-going up to the post-intervention time point. Primary outcomes are time spent sitting and in PA assessed via accelerometers and inclinometers and survey. Discussion To our knowledge, Transform-Us! is the first RCT to examine the effectiveness of intervention strategies for reducing children's overall sedentary time, promoting PA and optimizing health outcomes. The integration

  8. Quantum Mechanical/Molecular Mechanical Free Energy Simulations of the Glutathione S-Transferase (M1-1) Reaction with Phenanthrene 9,10-Oxide

    NARCIS (Netherlands)

    Ridder, L.; Rietjens, I.M.C.M.; Vervoort, J.J.M.; Mulholland, A.J.

    2002-01-01

    Glutathione S-transferases (GSTs) play an important role in the detoxification of xenobiotics in mammals. They catalyze the conjugation of glutathione to a wide range of electrophilic compounds. Phenanthrene 9,10-oxide is a model substrate for GSTs, representing an important group of epoxide

  9. One-pot Microwave-Assisted Synthesis of 1H-Phenanthro[9,10- d][1,2,3]triazole

    Directory of Open Access Journals (Sweden)

    Mehrak Faraji

    2008-09-01

    Full Text Available In this study, a fast and good yield one-pot microwave-assisted synthesis (45 seconds of 1H-phenanthro[9,10-d][1,2,3]triazole by a 1,3-dipolar cycloaddition reaction of sodium azide and 9-bromophenanthrene in the presence of potassium tert-butoxide in DMSO as solvent is reported.

  10. NaCl islands decorated with 2D or 3D 3,4,9,10-perylene-tetracarboxylic-dianhydride nanostructures

    NARCIS (Netherlands)

    Sun, Xiaonan; Silly, Fabien

    2010-01-01

    The formation of PTCDA (3,4,9,10-perylene-tetracarboxylic-dianhydride) nanostrutures on Au(1 1 1)-(22 x root 3) covered with NaCl islands has been studied using scanning tunneling microscopy (STM). Atomically resolved STM images show that NaCl grows as (1 0 0)-terminated layers on Au(1 1 1)-(22 x

  11. Proceedings of the Special Demonstration Workshop for Integrating Blind Children with Sighted Children into Ongoing Physical Education and Recreation Programs (Cleveland, Ohio, October 9-10, 1969).

    Science.gov (United States)

    Boninger, Walter B., Ed.

    A special education workshop (Cleveland, Ohio, October 9-10, 1969) for integrating blind children with sighted children into ongoing physical education and recreation programs is described. Physical education and blind children from the viewpoint of opthalmology, social and psychological aspects of blindness as they relate to participation in…

  12. Hydrogenation of 2-ethyl-9,10-anthraquinone on Pd-polyaniline(SiO.sub.2./sub.) composite catalyst. The effect of humidity

    Czech Academy of Sciences Publication Activity Database

    Drelinkiewicz, A.; Waksmundzka-Góra, A.; Sobczak, J.; Stejskal, Jaroslav

    2007-01-01

    Roč. 333, č. 2 (2007), s. 219-228 ISSN 0926-860X Institutional research plan: CEZ:AV0Z40500505 Keywords : 2-ethyl-9,10- anthraquinone * polyaniline * palladium catalysts Subject RIV: CD - Macromolecular Chemistry Impact factor: 3.166, year: 2007

  13. Face-to-Face Packing of 2,3,9,10-Tetrasubstituted Pentacene Derivatives Revealed through a Solid State [4 + 4] Thermal Cycloaddition and Molecular Dynamic Simulation.

    Science.gov (United States)

    Pal, Bikash; Lin, Bo-Chao; Dela Cerna, Mark Vincent Carreon; Hsu, Chao-Ping; Lin, Chih-Hsiu

    2016-08-05

    2,3,9,10-Substituted pentacene tetraesters and pentacene diester-dinitriles were synthesized. These pentacene derivatives underwent an unusual solid state [4 + 4] thermal dimerization with good efficiency and complete stereoselectivity. This observation indicates this series of pentacene derivatives adopt π-π stacking geometry with large mutual overlap in solid state. This notion was confirmed by molecualr dynamic simulation.

  14. An investigation of narrow meson resonance production in antiproton-proton and antiproton-neutron interactions at 6.1 and 8.9 GeV/c

    International Nuclear Information System (INIS)

    Azooz, F.; Butterworth, I.; Dornan, P.J.

    1984-04-01

    The authors made a comprehensive search for narrow meson resonance production in reactions of the type p-barN → π +- sub(fast)X and p-barN → psub(fast)(sub(n-bar)sup(p-bar)X at 6.1 and 8.9 GeV.c in a triggered bubble chamber experiment at the SLAC Hybrid Facility. From a study of all accessible inclusive, semi-inclusive and exclusive states, upper limits are given for production of non-strange resonances with width 2 . The authors find two further peaks of statistical significance in excess of 4 standard deviations with masses in the M approx. 2 GeV/c 2 region, and one further multipion peak with mass approx. 1.54 GeV/c 2 . (author)

  15. Investigation on the neutral and anionic BxAlyH2 (x + y = 7, 8, 9) clusters using density functional theory combined with photoelectron spectroscopy.

    Science.gov (United States)

    Ding, Li-Ping; Shao, Peng; Lu, Cheng; Zhang, Fang-Hui; Ding, Lei; Yuan, Tao Li

    2016-08-17

    The structure and bonding nature of neutral and negatively charged BxAlyH2 (x + y = 7, 8, 9) clusters are investigated with the aid of previously published experimental photoelectron spectra combined with the present density functional theory calculations. The comparison between the experimental photoelectron spectra and theoretical simulated spectra helps to identify the ground state structures. The accuracy of the obtained ground state structures is further verified by calculating their adiabatic electron affinities and vertical detachment energies and comparing them against available experimental data. The results show that the structures of BxAlyH2 transform from three-dimensional to planar structures as the number of boron atoms increases. Moreover, boron atoms tend to bind together forming Bn units. The hydrogen atoms prefer to bind with boron atoms rather than aluminum atoms. The analyses of the molecular orbital on the ground state structures further support the abovementioned results.

  16. El discurso hegemónico sobre las acciones colectivas de resistencia civil: Casos comunas 8, 9 y 13 de Medellín

    OpenAIRE

    Alzate Zuluaga, Mary Luz

    2010-01-01

    En este artículo se discute la manera cómo en la prensa escrita son informadas las distintas expresiones de resistencia civil, a partir del rastreo de la información registrada en la prensa escrita local y nacional acerca de los casos de las Comunas 8, 9 y 13 de la ciudad de Medellín durante los años 2002-2006. Se busca conocer así, de qué modo han sido descritas e interpretadas dichas prácticas, cuáles son las ausencias y los aspectos subrayados con lo emitido, qué relaciones de poder se leg...

  17. Exploratory study of fission product yields of neutron-induced fission of 235U , 238U , and 239Pu at 8.9 MeV

    Science.gov (United States)

    Bhatia, C.; Fallin, B. F.; Gooden, M. E.; Howell, C. R.; Kelley, J. H.; Tornow, W.; Arnold, C. W.; Bond, E.; Bredeweg, T. A.; Fowler, M. M.; Moody, W.; Rundberg, R. S.; Rusev, G. Y.; Vieira, D. J.; Wilhelmy, J. B.; Becker, J. A.; Macri, R.; Ryan, C.; Sheets, S. A.; Stoyer, M. A.; Tonchev, A. P.

    2015-06-01

    Using dual-fission chambers each loaded with a thick (200 -400 -mg /c m2) actinide target of 235 ,238U or 239Pu and two thin (˜10 -100 -μ g /c m2) reference foils of the same actinide, the cumulative yields of fission products ranging from 92Sr to 147Nd have been measured at En= 8.9 MeV . The 2H(d ,n ) 3He reaction provided the quasimonoenergetic neutron beam. The experimental setup and methods used to determine the fission product yield (FPY) are described, and results for typically eight high-yield fission products are presented. Our FPYs for 235U(n ,f ) , 238U(n ,f ) , and 239Pu(n ,f ) at 8.9 MeV are compared with the existing data below 8 MeV from Glendenin et al. [Phys. Rev. C 24, 2600 (1981), 10.1103/PhysRevC.24.2600], Nagy et al. [Phys. Rev. C 17, 163 (1978), 10.1103/PhysRevC.17.163], Gindler et al. [Phys. Rev. C 27, 2058 (1983), 10.1103/PhysRevC.27.2058], and those of Mac Innes et al. [Nucl. Data Sheets 112, 3135 (2011), 10.1016/j.nds.2011.11.009] and Laurec et al. [Nucl. Data Sheets 111, 2965 (2010), 10.1016/j.nds.2010.11.004] at 14.5 and 14.7 MeV, respectively. This comparison indicates a negative slope for the energy dependence of most fission product yields obtained from 235U and 239Pu , whereas for 238U the slope issue remains unsettled.

  18. Synthesis and Electroluminescence Properties of 3-(Trifluoromethylphenyl-Substituted 9,10-Diarylanthracene Derivatives for Blue Organic Light-Emitting Diodes

    Directory of Open Access Journals (Sweden)

    Sang Woo Kwak

    2017-10-01

    Full Text Available Diaryl-substituted anthracene derivatives containing 3-(trifluoromethylphenyl groups, 9,10-diphenyl-2-(3-(trifluoromethylphenylanthracene (1, 9,10-di([1,1′-biphenyl]-4-yl-2-(3-(trifluoromethylphenylanthracene (2, and 9,10-di(naphthalen-2-yl-2-(3-(trifluoromethylphenylanthracene (3 were synthesized and characterized. The compounds 1–3 possessed high thermal stability and proper frontier-energy levels, which make them suitable as host materials for blue organic light-emitting diodes. The electroluminescent (EL emission maximum of the three N,N-diphenylamino phenyl vinyl biphenyl (DPAVBi-doped (8 wt % devices for compounds 1–3 was exhibited at 488 nm (for 1 and 512 nm (for 2 and 3. Among them, the 1-based device displayed the highest device performances in terms of brightness (Lmax = 2153.5 cd·m−2, current efficiency (2.1 cd·A−1, and external quantum efficiency (0.8%, compared to the 2- and 3-based devices.

  19. An investigation of narrow meson resonance production in antiproton-proton and antiproton-neutron interactions at 6.1 and 8.9 GeV/c

    International Nuclear Information System (INIS)

    Azooz, F.; Butterworth, I.; Dornan, P.J.; Hall, G.; Stern, R.A.; White, A.P.; Brown, R.C.; Butler, N.; Gopal, G.P.; McPherson, A.; Sekulin, R.L.; Brau, J.E.; Carroll, J.T.; Chaloupka, V.; Cautis, C.V.; Dumont, J.J.; Ericson, R.A.; Field, R.C.; Freytag, D.R.; Grandpeix, J.Y.; Kitagaki, T.; Tanaka, S.; Yuta, H.; Abe, K.; Hasegawa, K.; Yamaguchi, A.; Tamai, K.; Takanashi, H.; Mann, W.A.; Schneps, J.; Wald, H.B.

    1984-01-01

    We have made a comprehensive search for narrow meson resonance production in reactions of the type anti pN->πsub(fast)sup(+-)X and anti pN->psub(fast)X at 6.1 and 8.9 Gev/c in a triggered bubble chamber experiment at the SLAC hybrid facility. From a study of all accessible inclusive, semi-inclusive and exclusive states we give upper limits for production of non-strange resonances with width 2 . In a previous publication [1] we gave evidence for production of a narrow state of mass 2.02 GeV/c 2 , coupled to Nanti N, in our data. In the present study we find two further peaks of statistical significance in excess of 4 standard deviations with masses in the Mproportional2 GeV/c 2 region, and one further multipion peak with mass proportional1.54 GeV/c 2 , all of which merit further experimental investigation. (orig.)

  20. El discurso hegemónico sobre las acciones colectivas de resistencia civil. Casos comunas 8, 9 y 13 de Medellín

    Directory of Open Access Journals (Sweden)

    Mary Luz Alzate Zuluaga

    2010-01-01

    Full Text Available En este artículo se discute la manera cómo en la prensa escrita son informadas las distintas expresiones de resistencia civil, a partir del rastreo de la información registrada en la prensa escrita local y nacional acerca de los casos de las Comunas 8, 9 y 13 de la ciudad de Medellín durante los años 2002-2006. Se busca conocer así, de qué modo han sido descritas e interpretadas dichas prácticas, cuáles son las ausencias y los aspectos subrayados con lo emitido, qué relaciones de poder se legitiman, entre otras cuestiones. Llegando a afirmar la existencia de un discurso difundido y legitimado en los medios masivos de comunicación, acorde con el orden social y político hegemónico y dominante en Colombia. Este discurso consiste en la invisibilidad de los mensajes políticos de denuncia y oposición frente a los actores armados y sus dinámicas de guerra, y también consiste en la minimización del desafío de las prácticas colectivas producidas cotidianamente en defensa de los derechos vulnerados de los habitantes de los barrios populares y en busca del reconocimiento y justicia frente a la exclusión social y política.

  1. Clinical Outcomes for Patients with Gleason Score 9-10 Prostate Adenocarcinoma Treated With Radiotherapy or Radical Prostatectomy: A Multi-institutional Comparative Analysis.

    Science.gov (United States)

    Kishan, Amar U; Shaikh, Talha; Wang, Pin-Chieh; Reiter, Robert E; Said, Jonathan; Raghavan, Govind; Nickols, Nicholas G; Aronson, William J; Sadeghi, Ahmad; Kamrava, Mitchell; Demanes, David Jeffrey; Steinberg, Michael L; Horwitz, Eric M; Kupelian, Patrick A; King, Christopher R

    2017-05-01

    The long natural history of prostate cancer (CaP) limits comparisons of efficacy between radical prostatectomy (RP) and external beam radiotherapy (EBRT), since patients treated years ago received treatments considered suboptimal by modern standards (particularly with regards to androgen deprivation therapy [ADT] and radiotherapy dose-escalation]. Gleason score (GS) 9-10 CaP is particularly aggressive, and clinically-relevant endpoints occur early, facilitating meaningful comparisons. To compare outcomes of patients with GS 9-10 CaP following EBRT, extremely-dose escalated radiotherapy (as exemplified by EBRT+brachytherapy [EBRT+BT]), and RP. Retrospective analysis of 487 patients with biopsy GS 9-10 CaP treated between 2000 and 2013 (230 with EBRT, 87 with EBRT+BT, and 170 with RP). Most radiotherapy patients received ADT and dose-escalated radiotherapy. Kaplan-Meier analysis and multivariate Cox regression estimated and compared 5-yr and 10-yr rates of distant metastasis-free survival, cancer-specific survival (CSS), and overall survival (OS). The median follow-up was 4.6 yr. Local salvage and systemic salvage were performed more frequently in RP patients (49.0% and 30.1%) when compared with either EBRT patients (0.9% and 19.7%) or EBRT+BT patients (1.2% and 16.1%, pRadiotherapy and RP provide equivalent CSS and OS. Extremely dose-escalated radiotherapy with ADT in particular offers improved systemic control when compared with either EBRT or RP. These data suggest that extremely dose-escalated radiotherapy with ADT might be the optimal upfront treatment for patients with biopsy GS 9-10 CaP. While some prostate cancers are slow-growing requiring many years, sometimes decades, of follow-up in order to compare between radiation and surgery, high-risk and very aggressive cancers follow a much shorter time course allowing such comparisons to be made and updated as treatments, especially radiation, rapidly evolve. We showed that radiation-based treatments and surgery

  2. Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus.

    Science.gov (United States)

    Del Puerto, H L; Martins, A S; Moro, L; Milsted, A; Alves, F; Braz, G F; Vasconcelos, A C

    2010-01-26

    Canine distemper is an immunosuppressive disease caused by the canine distemper virus (CDV). Pathogenesis mainly involves the central nervous system and immunosuppression. Dogs naturally infected with CDV develop apoptotic cells in lymphoid tissues and the cerebellum, but this apoptotic mechanism is not well characterized. To better understand this process, we evaluated the expression of Bax, Bcl-2, and caspase-3, -8 and -9, by evaluating mRNA levels in the peripheral blood, lymph nodes and cerebellum of CDV-infected (CDV+) and uninfected (CDV-) dogs by real-time polymerase chain reaction (PCR). Blood samples from 12 CDV+ and 8 CDV- dogs, diagnosed by reverse transcription-PCR, were subjected to hematological analysis and apoptotic gene expression was evaluated using real-time-PCR. Tissues from the cerebellum and lymph nodes of four CDV+ and three CDV-dogs were also subjected to real time-PCR. No significant differences were found between CDV+ and CDV- dogs in the hemotological results or in the expression of caspase-3, -8, -9, Bax, and Bcl-2 in the peripheral blood. However, expression of Bax, caspase-3, -8 and -9 was significantly higher in the cerebellum of CDV+ compared to CDV- dogs. Expression of caspase-3 and -8 was significantly higher in the lymph nodes of CDV+ compared to CDV- dogs. We concluded that infection with CDV induces apoptosis in the cerebellum and lymph nodes in different ways. Lymph node apoptosis apparently occurs via caspase-3 activation, through the caspase-8 pathway, and cerebellum apoptosis apparently occurs via caspase-3 activation, through the caspase-8 and mitochondrial pathways.

  3. Holocene environmental change along the southern Cape coast of South Africa - Insights from the Eilandvlei sediment record spanning the last 8.9 kyr

    Science.gov (United States)

    Wündsch, Michael; Haberzettl, Torsten; Cawthra, Hayley C.; Kirsten, Kelly L.; Quick, Lynne J.; Zabel, Matthias; Frenzel, Peter; Hahn, Annette; Baade, Jussi; Daut, Gerhard; Kasper, Thomas; Meadows, Michael E.; Mäusbacher, Roland

    2018-04-01

    This study investigates Holocene sediments from Eilandvlei, a coastal lake located within the Wilderness embayment at the southern Cape coast of South Africa. The evolution of the present estuarine/coastal lake system is reconstructed based on seismic data as well as a multi-proxy approach on a 30.5 m sediment core spanning the last 8.9 kyr. Geochemical (Ca, TOC/S, Br/TOC) and micropalaeontological data (diatoms, foraminifera) reflect changes in the degree of marine influence at the core site. The embayment likely developed via distinct phases of connectivity to the Indian Ocean caused by sea level changes and dune progradation. Marine conditions prevailed at the core site from 8900 to 4700 cal BP. The rapid sea level rise during the early Holocene caused the inundation of a palaeovalley that most likely had formed at lower sea levels during the Pleistocene. Towards the mid-Holocene the sea level exceeded its present height around 7500 cal BP creating a marine embayment. At 4700 cal BP, the embayment became distinctly more disconnected from the ocean turning into a lagoon system that persisted until 1200 cal BP. Subsequently, the marine influence further decreased and the present estuarine/coastal lake system was established. Grain size and geochemical data (Fe, Si/Al, chemical index of alteration (CIA)) further reflect changes in the deposition of terrigenous sediments at the core site. While the sedimentation of fine-grained (climatic conditions than today from 8900 to 7900 cal BP and 6400 to 3000 cal BP. In contrast, the periods between 7900-6400 cal BP and 3000 cal BP-present were likely characterized by high river discharge and thus, generally more rainfall. The reconstructed palaeoclimatic variations are discussed within the context of e.g., shifts in the position of the Antarctic sea ice extent and the mid-latitude westerly wind belt as well as changes in the El Niño-Southern Oscillation (ENSO).

  4. Features of the Diels-Alder reaction between 9,10-diphenylanthracene and 4-phenyl-1,2,4-triazoline-3,5-dione

    Science.gov (United States)

    Kiselev, V. D.; Kornilov, D. A.; Kashaeva, E. A.; Potapova, L. N.; Krivolapov, D. B.; Litvinov, I. A.; Konovalov, A. I.

    2014-12-01

    The Diels-Alder reaction between substituted anthracenes 1a-1j and 4-phenyl-1,2,4-triazoline-3,5 ( 2) is studied. In all cases except one, the reaction proceeds on the most active 9,10-atoms of substituted anthracenes. The orthogonality of the two phenyl groups at the 9,10-position of diene 1a is found to shield 9,10-reactive centers. No dienophiles with C=C bonds are shown to participate in the Diels-Alder reaction with 1a; however, the reaction 1a + 2 proceeds with the very active dienophile 2,4-phenyl-1,2,4-triazoline-3,5-dione. It is shown that attachment occurs on the less active but sterically accessible 1,4-reactive center of diene 1a. The structure of adduct 3a is proved by 1H and 13C NMR spectroscopy and X-ray diffraction analysis. The following parameters are obtained for reaction 1a + 2 ⇆ 3a in toluene at 25°C: K eq = 2120 M-1, Δ Hf ≠ = 58.6 kJ/mol, Δ Sf ≠ = -97 J/(mol K), Δ Vf ≠ = -17.2 cm3/mol, Δ Hb ≠ = 108.8 kJ/mol, Δ Sb ≠ = 7.3 J/(mol K), Δ Vb ≠ = -0.8 cm3/mol, Δ H r-n = -50.2 kJ/mol, Δ S r-n = -104.3 J/(mol K), Δ V r-n = -15.6 cm3/mol. It is concluded that the values of equilibrium constants of the reactions 1a-1j + 2 ⇆ 3a-3j vary within 4 × 101-1011 M-1.

  5. Association between breast milk intake at 9-10 months of age and growth and development among Malawian young children.

    Science.gov (United States)

    Kumwenda, Chiza; Hemsworth, Jaimie; Phuka, John; Ashorn, Ulla; Arimond, Mary; Maleta, Kenneth; Prado, Elizabeth L; Haskell, Marjorie J; Dewey, Kathryn G; Ashorn, Per

    2018-01-19

    World Health Organization recommends exclusive breastfeeding for infants for the first 6 months of life, followed by introduction of nutritious complementary foods alongside breastfeeding. Breast milk remains a significant source of nourishment in the second half of infancy and beyond; however, it is not clear whether more breast milk is always better. The present study was designed to determine the association between amount of breast milk intake at 9-10 months of age and infant growth and development by 12-18 months of age. The study was nested in a randomized controlled trial conducted in Malawi. Regression analysis was used to determine associations between breast milk intake and growth and development. Mean (SD) breast milk intake at 9-10 months of age was 752 (244) g/day. Mean (SD) length-for-age z-score at 12 months and change in length-for-age z-score between 12 and 18 months were -1.69 (1.0) and -0.17 (0.6), respectively. At 18 months, mean (SD) expressive vocabulary score was 32 (24) words and median (interquartile range) skills successfully performed for fine, gross, and overall motor skills were 21 (19-22), 18 (16-19), and 38 (26-40), respectively. Breast milk intake (g/day) was not associated with either growth or development. Proportion of total energy intake from breast milk was negatively associated with fine motor (β = -0.18, p = .015) but not other developmental scores in models adjusted for potential confounders. Among Malawian infants, neither breast milk intake nor percent of total energy intake from breast milk at 9-10 months was positively associated with subsequent growth between 12 and 18 months, or development at 18 months. © 2018 John Wiley & Sons Ltd.

  6. Synthesis, photophysical, structural and electronic properties of novel regioisomerically pure 1,7-disubstituted perylene-3,4,9,10-tetracarboxylic monoimide dibutylester derivatives

    Science.gov (United States)

    Ozser, Mustafa E.; Mohiuddin, Obaidullah

    2018-04-01

    Three new isomerically pure 1,7-disubstituted perylene-3,4,9,10-tetracarboxylic monoimide dibutylester derivatives namely; N-[2-(diethylamino)ethyl]-1,7-dibromoperylene-3,4,9,10-tetracarboxy monoimide dibutylester (PMD-1), N-[2-(diethylamino)ethyl]-1,7-di(4-tert-butylphenoxy)perylene-3,4,9,10-tetracarboxy monoimide dibutylester (PMD-2) and N-[2-(diethylamino)ethyl]-1,7-di(pyrrolidinyl)perylene-3,4,9,10-tetracarboxy monoimide dibutylester (PMD-3), have been synthesized and their electronic absorption spectra, and steady-state fluorescence were investigated experimentally as well as by using density functional theory (DFT) calculations. All three compounds show good solubility in toluene and chloroform. Attachment of two tert-butylphenoxy groups at the 1,7-positions in PMD-2 resulted in a red shifted absorption band with an absorption maximum at 518 nm. UV/Vis absorption spectrum of PMD-3 bearing electron donating pyrrolidinyl groups at the 1,7-positions shows a broad absorption band within the visible region, extending to red region. Absorption maximum of lowest energy transition now shifts to 653 nm. In addition to the S0 → S1 absorption bands, bands belonging to S0 → S2 electronic transitions were observed at 378, 386, and 411 nm for PMD-1, PMD-2, and PMD-3 respectively. Compounds PMD-1, PMD-2 and PMD-3 display low fluorescence quantum yields of 0.027, 0.040 and 0.001, respectively in chloroform. DFT calculations revealed that the attachment of electron donating groups at 1,7-positions of perylene core, results in an increase in frontier orbitals energy levels. Observed energy increase in HOMO level is larger in each case, compared to the energy increase in LUMO levels, due to the higher contribution of side groups to HOMO. DFT calculated band gaps for PMD-1, PMD-2 and PMD-3 are 2.68, 2.63 and 2.29 eV respectively.

  7. Interfacial spectroscopic characterization of organic/ferromagnet hetero-junction of 3,4,9,10-perylene-teracarboxylic dianhydride-based organic spin valves

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jhen-Yong; Ou Yang, Kui-Hon; Li, Kai-Shin [Department of Physics, National Taiwan University, 10617 Taipei, Taiwan (China); Wang, Bo-Yao [Department of Physics, National Taiwan University, 10617 Taipei, Taiwan (China); Department of Physics, National Changhua University of Education, Changhua 500, Taiwan (China); Shiu, Hung-Wei; Chen, Chia-Hao; Chan, Yuet-Loy; Wei, Der-Hsin; Chang, Fan-Hsiu; Lin, Hong-Ji [National Synchrotron Radiation Research Center, 30076 Hsinchu, Taiwan (China); Chiang, Wen-Chung, E-mail: wchiang@faculty.pccu.edu.tw [Department of Physics, Chinese Culture University, 11114 Taipei, Taiwan (China); Lin, Minn-Tsong, E-mail: mtlin@phys.ntu.edu.tw [Department of Physics, National Taiwan University, 10617 Taipei, Taiwan (China); Institute of Atomic and Molecular Sciences, Academia Sinica, 10617 Taipei, Taiwan (China)

    2014-02-24

    We report interfacial characterization of 3,4,9,10-perylene-teracarboxylic dianhydride (PTCDA)-based organic spin valves (OSV) dusted with a thin layer of partially oxidized alumina at the organic semiconductor (OSC)/ferromagnet (FM) interfaces. Up to 13.5% magnetoresistance is achieved at room temperature. X-ray photoelectron spectroscopy measurements reveal interfacial electronic interaction between PTCDA and FM while the application of a thin alumina layer at the PTCDA/FM interfaces prevents the electronic hybridization and effectively preserves the spin injection into the OSC spacer. This finding demonstrates the critical effect of interfacial structure on magnetotransport behavior in OSV.

  8. Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy); March 9-10, 2018

    OpenAIRE

    --- Various Authors

    2018-01-01

    Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy); March 9-10, 2018CONGRESS PRESIDENTPaolo Biban  Guest Editor: Paolo BibanABS 1. DOES DELAYED CORD CLAMPING (DCC) AFFECT UMBILICAL CORD pH IN PRETERM INFANTS? • V.M. Samedi, L. Irvine, S. Thomas, D. Kowal, J. Rabi, A. Stritzke, N. Singhal, A. Abou MehremABS 2. SNAP-PE SCORE. MORBIDITY AND MOR­TALI­TY INDEX IN NICUs • A. Konstantinidi, R. Sokou, S. Parastatidou, A. Tsantes, N. IacovidouABS 3. EA...

  9. Laser induced transient absorptions of the excited triplet state of 9,10-anthraquinone-2-sulfonate. A further study by 248 nm laser photolysis

    International Nuclear Information System (INIS)

    Ma Jianhua; Lin Weizheng; Wang Wenfen; Yao Side; Lin Nianyun

    1999-01-01

    Transient absorption spectrum of triplet state of 9,10-anthraquinone-2-sulfonate (AQS) in aqueous solution has been investigated using 248 nm (KrF) laser photolysis. A whole transient absorption spectrum with absorption maxim at 380 nm and 580 nm has been assigned to triple AQS from detailed kinetic analysis of decay of 380 nm and 580 nm signals, which is the neat characteristic absorption of triplet AQS reported for the first time. In addition, the difference in feature of the spectrum of triplet AQS in H 2 O and that in CH 3 CN was eliminated by further study using 248 nm laser pulses

  10. Structural and functional cardiac adaptations to a 10-week school-based football intervention for 9-10-year-old children

    DEFF Research Database (Denmark)

    Krustrup, Peter; Hansen, Peter Riis; Nielsen, Claus Malta

    2014-01-01

    -randomized into a control group that maintained their usual activities (CON; two classes, n = 51, 21 boys and 30 girls) and a football training group that performed an additional 3 × 40 min of small-sided football training per week (FT; two classes, n = 46, 23 boys and 23 girls). No baseline differences were observed......The present study investigated the cardiac effects of a 10-week football training intervention for school children aged 9-10 years using comprehensive transthoracic echocardiography as a part of a larger ongoing study. A total of 97 pupils from four school classes were cluster...

  11. 9-Arylvinyl- and 9,10-bis(arylvinyl)-anthracenes with phenyl and naphthyl as aryl moieties: Differential aggregation behaviors and optoelectronic properties

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Jing; Liu, Wei; Ying, Shian; Wu, Yongjin [Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Province (QUST), School of Polymer Science & Engineering, Qingdao University of Science & Technology, 53-Zhengzhou Road, Qingdao 266042 (China); Xue, Shanfeng, E-mail: sfxue@qust.edu.cn [Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Province (QUST), School of Polymer Science & Engineering, Qingdao University of Science & Technology, 53-Zhengzhou Road, Qingdao 266042 (China); State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640 (China); Yang, Wenjun, E-mail: ywjph2004@qust.edu.cn [Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Province (QUST), School of Polymer Science & Engineering, Qingdao University of Science & Technology, 53-Zhengzhou Road, Qingdao 266042 (China)

    2016-08-15

    In this paper, we have synthesized our simple twisting arylvinyl anthracene derivatives, 9-styrylanthracene (ASB), 9,10-bis(styryl)anthracene (SB), 9-(2-(naph- thalen-1-yl)vinyl)anthracene (ASN) and 9,10-bis((naphthalen-1-yl)vinyl)anthracene (SN), to demonstrate the effect of skeleton symmetry on optical and optoelectronic properties. The results showed that SB and SN are weak emission with the fluorescence quantum yields (Φ) of ca. 7% but ASB and ASN are highly fluorescent (Φ≈50%) in THF solution, although they all exhibit high solid-state fluorescence efficiencies (22~50%). Grinding could induce about 20 nm of spectral shift of ASB and ASN crystalline fluorescence, but SB and SN crystals hardly exhibit mechano- fluorochromic behavior. Furthermore, the evaporated films of SB and SN are fragile due to re-crystallization soon, but those of ASB and ASN are stable and could be used as the bulk emissive layer exhibiting commendable electroluminescent performances. This finding indicates that the geometric structures of conjugated skeletons could influence the electronic and aggregate structure of organic luminogens, and then alter their optical and optoelectronic properties.

  12. Study of interaction between tin dioxide nanoparticle and 1,4-dihydroxy 2,3-dimethyl 9,10-anthraquinone sensitizer

    International Nuclear Information System (INIS)

    Suvetha Rani, J.; Sasirekha, V.; Ramakrishnan, V.

    2013-01-01

    The interaction between 1,4-dihydroxy 2,3-dimethyl 9,10-anthraquinone (DHDMAQ) and tin dioxide nanoparticle (SnO 2 NPs) has been investigated using optical absorption and emission techniques. Tin dioxide nanoparticles have been synthesized by chemical precipitation method. The experimental results reveal that the fluorescence intensity of 1,4-dihydroxy 2,3-dimethyl 9,10-anthraquinone has been quenched as the concentration of the SnO 2 NPs increased. The Stern–Volmer plot indicates that SnO 2 NPs have dynamic quenching efficiency on the fluorescence nature of DHDMAQ. The obtained value of the association constant infers that there is an association between DHDMAQ and the SnO 2 nanoparticles. -- Highlights: • The interaction between DHDMAQ and SnO 2 NPs has been investigated using optical absorption and emission techniques. • The fluorescence intensity of the fluorophore has been quenched as the concentration of the SnO 2 NPs increased. • The Stern–Volmer plot indicates that SnO 2 NPs have dynamic quenching efficiency on the fluorescence nature of DHDMAQ

  13. Quinoidal Oligo(9,10-anthryl)s with Chain-Length-Dependent Ground States: A Balance between Aromatic Stabilization and Steric Strain Release

    KAUST Repository

    Lim, Zhenglong

    2015-11-12

    Quinoidal π-conjugated polycyclic hydrocarbons have attracted intensive research interest due to their unique optical/electronic properties and possible magnetic activity, which arises from a thermally excited triplet state. However, there is still lack of fundamental understanding on the factors that determine the electronic ground states. Herein, by using quinoidal oligo(9,10-anthryl)s, it is demonstrated that both aromatic stabilisation and steric strain release play balanced roles in determining the ground states. Oligomers with up to four anthryl units were synthesised and their ground states were investigated by electronic absorption and electron spin resonance (ESR) spectroscopy, assisted by density functional theory (DFT) calculations. The quinoidal 9,10-anthryl dimer 1 has a closed-shell ground state, whereas the tri- (2) and tetramers (3) both have an open-shell diradical ground state with a small singlet-triplet gap. Such a difference results from competition between two driving forces: the large steric repulsion between the anthryl/phenyl units in the closed-shell quinoidal form that drives the molecule to a flexible open-shell diradical structure, and aromatic stabilisation due to the gain of more aromatic sextet rings in the closed-shell form, which drives the molecule towards a contorted quinoidal structure. The ground states of these oligomers thus depend on the overall balance between these two driving forces and show chain-length dependence. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Aggregation-enhanced emission and piezochromic luminescence of 9,10-bis(p-dibutylaminostyryl)-2,6-bis(p-t-butylstyryl)anthracene

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Mingxiao; Zhang, Deteng; Li, Yiping; Wang, Jianfeng; Gao, Yangyang; Yang, Wenjun, E-mail: ywjph2004@qust.edu.cn

    2014-04-15

    A cruciform 9,10-distyrylanthracene-containing luminogen, 9,10-bis(p-dibutylaminostyryl)-2,6-bis(p-t-butylstyryl)anthracene (DDC), has been synthesized and the optical properties investigated. The results show that DDC is an aggregation-induced enhanced emission (AIEE) and piezofluorochromic (PFC) dye. The fluorescence quantum yield in THF/water=1/9 (18.1%) is about 12-fold over that in THF (1.53%). PFC experiment shows that the fluorescence colors (emission spectra) of DDC solid change reversibly between orange-red (602 nm) and red (632 nm) emissions upon pressing and annealing. Wide-angle X-ray diffraction and differential scanning calorimetric analyses reveal that the grinding has induced the phase transition of DDC solid from pristine crystalline to ground amorphous states, and annealing could cause the re-crystallization of amorphized DDC solid. This transformation between crystalline and amorphous states is responsible for the reversible PFC behavior upon external stimuli. Highlights: • A two-dimensional cross-conjugated luminogen (DDC) was synthesized. • DDC exhibits aggregation-enhanced emission and piezofluorochromic behaviors. • DDC emits bluer light in the crystalline phase than in the amorphous phase. • The PFC mechanism is ascribed to grinding-induced amorphization.

  15. Major earthquake of Friday March 11, 2011, magnitude 8.9 at 5:46 UT, off Honshu island (Japan); Seisme majeur au large de l'Ile d'Honshu (Japon) du vendredi 11 mars 2011 Magnitude = 8,9 a 5h46 (TU)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    On Friday March 11, 2011, at 5:46 UT (2:46 PM local time), a magnitude 8.9 earthquake took place at 80 km east of Honshu island (Japan). The earthquake affected a large part of the Honshu territory and led to the automatic emergency shutdown of all nuclear power plants of the east coast. This paper recalls first the seismo-tectonic and historical seismic context of the Japan archipelago and the first analyses of the Tohoku earthquake impact on nuclear facilities. At the time of publication of this information report, no radioactive release in the environment and no anomaly at the Tokai-Mura and Rokkasho-Mura sites were mentioned. However, the evacuation of populations in a 3 to 10 km area around the Fukushima-Dai-ichi power plant had been ordered by the Governor as preventive measure, which made one think that the situation at this specific site was particularly worrying. (J.S.)

  16. El discurso hegemónico sobre las acciones colectivas de resistencia civil: Casos comunas 8, 9 y 13 de Medellín The Hegemonic Discourse about Collective Actions of Civil Resistance: Cases Communes 8, 9 and 13 of Medellín

    OpenAIRE

    Mary Luz Alzate Zuluaga

    2010-01-01

    En este artículo se discute la manera cómo en la prensa escrita son informadas las distintas expresiones de resistencia civil, a partir del rastreo de la información registrada en la prensa escrita local y nacional acerca de los casos de las Comunas 8, 9 y 13 de la ciudad de Medellín durante los años 2002-2006. Se busca conocer así, de qué modo han sido descritas e interpretadas dichas prácticas, cuáles son las ausencias y los aspectos subrayados con lo emitido, qué relaciones de poder se leg...

  17. A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10.

    Directory of Open Access Journals (Sweden)

    Jacopo Lucchetti

    Full Text Available Oxidative stress and mitochondrial impairment are the main pathogenic mechanisms of Amyotrophic Lateral Sclerosis (ALS, a severe neurodegenerative disease still lacking of effective therapy. Recently, the coenzyme-Q (CoQ complex, a key component of mitochondrial function and redox-state modulator, has raised interest for ALS treatment. However, while the oxidized form ubiquinone10 was ineffective in ALS patients and modestly effective in mouse models of ALS, no evidence was reported on the effect of the reduced form ubiquinol10, which has better bioavailability and antioxidant properties. In this study we compared the effects of ubiquinone10 and a new stabilized formulation of ubiquinol10 on the disease course of SOD1(G93A transgenic mice, an experimental model of fALS. Chronic treatments (800 mg/kg/day orally started from the onset of disease until death, to mimic the clinical trials that only include patients with definite ALS symptoms. Although the plasma levels of CoQ10 were significantly increased by both treatments (from <0.20 to 3.0-3.4 µg/mL, no effect was found on the disease progression and survival of SOD1(G93A mice. The levels of CoQ10 in the brain and spinal cord of ubiquinone10- or ubiquinol10-treated mice were only slightly higher (≤10% than the endogenous levels in vehicle-treated mice, indicating poor CNS availability after oral dosing and possibly explaining the lack of pharmacological effects. To further examine this issue, we measured the oxidized and reduced forms of CoQ9/10 in the plasma, brain and spinal cord of symptomatic SOD1(G93A mice, in comparison with age-matched SOD1(WT. Levels of ubiquinol9/10, but not ubiquinone9/10, were significantly higher in the CNS, but not in plasma, of SOD1(G93A mice, suggesting that CoQ redox system might participate in the mechanisms trying to counteract the pathology progression. Therefore, the very low increases of CoQ10 induced by oral treatments in CNS might be not sufficient to

  18. Chiral synthesis of (Z)-3-cis-6,7-cis-9,10-diepoxyhenicosenes, sex pheromone components of the satin moth, Leucoma salicis.

    Science.gov (United States)

    Wimalaratne, Priyantha D C; Slessor, Keith N

    2004-06-01

    All four isomers of (Z)-3-cis-6,7-cis-9,10-diepoxyhenicosenes, 1-4, have been synthesized using D-xylose as the chirally pure starting material. D-Xylose was first converted to 2-deoxy-4,5-O-isopropylidene-3-t-butyldimethylsilyl-D-threopentose 11, via several steps of selective protection, dehydroxylation, and deprotection. Wittig coupling of 11 with nonyltriphenylphosphonium bromide followed by hydrogenation and acid catalyzed deprotection of hydroxyl groups yielded the chiral (2R,3R)-1,2,3-triol, 14, which was used as the precursor for the C-8 to C-21 unit of the (Z)-3-cis-6,7-cis-9,10-diepoxyhenicosenes. Selective tosylation of 14 followed by stereospecific cyclization yielded (2R,3R)-1,2-epoxytetradecan-3-ol, 16, which was then divergently converted to the t-butyldimethylsilyl ether 17 and tosylate 22, respectively. Establishment of the C-5 through C-7 unit of the target molecules was accomplished via regiospecific coupling of 17 with 1-t-butyldimethylsiloxy-2-propyne to form 18. Stepwise transformation of 18 via the formation of tosylate 19, desilylation, and stereospecific cyclization to form epoxy alcohol 20, followed by P2-Ni reduction yielded a key intermediate, allylic epoxy alcohol (Z)-2-(5S,6R)-cis-5,6-epoxyheptadecen-1-ol, 21. Similarly, the coupling of 22 with 1-t-butyldimethylsiloxy-2-propyne yielded 23, which was stereospecifically cyclized to form 24. Desilylation and P2-Ni reduction of 24 gave the antipodal intermediate, (Z)-2-(5R,6S)-cis-5,6-epoxyheptadecen-1-ol, 26. Asymmetric epoxidation of antipodes 21 and 26 with (L)- or (D)-diethyl tartrates resulted in the formation of diepoxy alcohols 27 and 29 from 21, and 33 and 31 from 26, respectively. Tosylation of these diepoxy alcohols followed by coupling with lithium dibutenyl cuprate yielded the four stereoisomers of (Z)-3-cis-6,7-cis-9,10-diepoxyhenicosenes, 1-4. Analysis of the retention characteristics of these materials revealed that one or both of the S*,R*,S*,R* stereoisomers comprise the

  19. Screening the best catalyst with group 9, 10 and 11 metals monolayer loading on NbC(001) from first-principles study

    Science.gov (United States)

    Kan, Dongxiao; Zhang, Xilin; Zhang, Yanxing; Yang, Zongxian

    2018-02-01

    The supported catalysts have received great attentions due to their high catalytic activity, low cost and good stability. Here we report the stability, wetting ability, corrosion resistance and catalytic activity of the supported catalysts with group 9, 10 and 11 metals (M = Co, Rh, Ir, Ni, Pd, Pt, Cu, Ag, Au) monolayers (ML) deposited on NbC(001), denoted as MML/NbC(001). The PdML/NbC(001) and PtML/NbC(001) are testified as the most stable and active ones with the former even better on the whole. The catalytic activities toward oxygen reduction reactions (ORR) are clarified by the dissociation and the change in Gibbs free energies for the elementary reaction steps of O2 on PdML/NbC(001).

  20. AC electrical conductivity and dielectric relaxation studies on n-type organic thin films of N, N‧-Dimethyl-3,4,9,10-perylenedicarboximide (DMPDC)

    Science.gov (United States)

    Qashou, Saleem I.; Darwish, A. A. A.; Rashad, M.; Khattari, Z.

    2017-11-01

    Both Alternating current (AC) conductivity and dielectric behavior of n-type organic thin films of N, N‧-Dimethyl-3,4,9,10-perylenedicarboximide (DMPDC) have been investigated. Fourier transformation infrared (FTIR) spectroscopy is used for identifying both powder and film bonds which confirm that there are no observed changes in the bonds between the DMPDC powder and evaporated films. The dependence of AC conductivity on the temperature for DMPDC evaporated films was explained by the correlated barrier hopping (CBH) model. The calculated barrier height using CBH model shows a decreasing behavior with increasing temperature. The mechanism of dielectric relaxation was interpreted on the basis of the modulus of the complex dielectric. The calculated activation energy of the relaxation process was found to be 0.055 eV.

  1. The HUPO Brain Proteome project wish list--summary of the 9(th) HUPO BPP Workshop 9-10 January 2008, Barbados.

    Science.gov (United States)

    Hamacher, Michael; Eisenacher, Martin; Tribl, Florian; Stephan, Christian; Marcus, Katrin; Hardt, Tanja; Wiltfang, Jens; Martens, Lennart; Desiderio, Dominic; Gutstein, Howard; Park, Young Mok; Meyer, Helmut E

    2008-06-01

    The Human Brain Proteome Project (HUPO BPP) aims at advancing knowledge and the understanding of neurodiseases and aging with the purpose of identifying prognostic and diagnostic biomarkers, as well as to push new diagnostic approaches and medications. The participating groups meet in semi-annual workshops to discuss the progress, as well as the needs, within the field of proteomics. The 9(th) HUPO BPP workshop took place in Barbados from 9-10 January, 2008. Discussing the future HUPO BPP Roadmap, the attendees drafted the so called HUPO BPP wish list containing timelines, suggestions and missions. This wish list will be updated regularly and will serve as a guideline for the next phase.

  2. Improved efficiency in organic light-emitting devices with tris-(8-hydroxyquinoline) aluminium doped 9,10-di(2-naphthyl) anthracene emission layer

    Energy Technology Data Exchange (ETDEWEB)

    Yuan Yongbo; Lian Jiarong; Li Shuang; Zhou Xiang [State Key Lab of Optoelectronic Materials and Technologies, Sun Yat-Sen University, Guangzhou, 510275 (China)], E-mail: stszx@mail.sysu.edu.cn

    2008-11-21

    Organic light-emitting devices with tris-(8-hydroxyquinoline) aluminium (Alq{sub 3}) doped 9,10-di(2-naphthyl) anthracene (ADN) as the emission layer (EML) have been fabricated. These devices exhibit efficient electroluminescence (EL) originated from the Alq{sub 3} as the mass ratio of Alq{sub 3} to ADN was varied from 1 to 50%. The devices with an optimal Alq{sub 3} mass ratio of 10 wt% showed a peak EL efficiency and an external quantum efficiency of 9.1 cd A{sup -1} and 2.7% at a luminance of 1371 cd m{sup -2}, which is improved by a factor of 2.2 compared with 4.1 cd A{sup -1} and 1.2% at a luminance of 3267 cd m{sup -2} for conventional devices with the neat Alq{sub 3} as the EML.

  3. NaCl islands decorated with 2D or 3D 3,4,9,10-perylene-tetracarboxylic-dianhydride nanostructures

    International Nuclear Information System (INIS)

    Sun Xiaonan; Silly, Fabien

    2010-01-01

    The formation of PTCDA (3,4,9,10-perylene-tetracarboxylic-dianhydride) nanostrutures on Au(1 1 1)-(22x√(3)) covered with NaCl islands has been studied using scanning tunneling microscopy (STM). Atomically resolved STM images show that NaCl grows as (1 0 0)-terminated layers on Au(1 1 1)-(22x√(3)). Local atomic hexagonal packing has also been observed in the NaCl(1 0 0) layer. At submonolayer NaCl coverage, PTCDA forms two-dimensional islands on the Au(1 1 1) surface and nucleate preferentially at the NaCl island step edges. When the Au surface is fully covered with NaCl layers, PTCDA molecules form three-dimensional molecular clusters decorating the step edges of NaCl layers.

  4. NaCl islands decorated with 2D or 3D 3,4,9,10-perylene-tetracarboxylic-dianhydride nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Sun Xiaonan [Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, NL-9747 AG Groningen (Netherlands); Silly, Fabien, E-mail: Fabien.silly@cea.fr [Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, NL-9747 AG Groningen (Netherlands); CEA, IRAMIS, SPCSI, Nanostructures and Organic Semiconductors Laboratory, F-91191 Gif-sur-Yvette (France); UPMC, IPCM, UMR CNRS 7201, 4 place Jussieu, F-75005 Paris (France)

    2010-01-15

    The formation of PTCDA (3,4,9,10-perylene-tetracarboxylic-dianhydride) nanostrutures on Au(1 1 1)-(22x{radical}(3)) covered with NaCl islands has been studied using scanning tunneling microscopy (STM). Atomically resolved STM images show that NaCl grows as (1 0 0)-terminated layers on Au(1 1 1)-(22x{radical}(3)). Local atomic hexagonal packing has also been observed in the NaCl(1 0 0) layer. At submonolayer NaCl coverage, PTCDA forms two-dimensional islands on the Au(1 1 1) surface and nucleate preferentially at the NaCl island step edges. When the Au surface is fully covered with NaCl layers, PTCDA molecules form three-dimensional molecular clusters decorating the step edges of NaCl layers.

  5. Interactions between 9,10-anthraquinone and aromatic amines in homogeneous and micellar media: A laser flash photolysis and magnetic field effect study

    International Nuclear Information System (INIS)

    Chowdhury, Adity; Basu, Samita

    2006-01-01

    The interactions between 9,10-anthraquinone (AQ) and different aromatic amines, N,N-dimethylaniline and 4,4'-bis (dimethylamino) diphenylmethane (DMDPM), have been studied using absorption, steady-state fluorescence, and laser flash photolysis techniques in organic homogeneous and heterogeneous micellar media. In polar organic homogeneous medium, electron transfer (ET) occurs from amines to excited AQ. In micellar medium, similar intermolecular ET is observed. However, in latter medium, ET predominates over hydrogen abstraction from micelles by excited AQ itself. The occurrence of ET has been further supported by the application of an external magnetic field during laser flash photolysis experiments, which modulates the yield of radical ion pairs formed through ET. Another novel feature, which has also been discussed here, is the abnormal behavior of DMDPM in micellar medium pertaining to energy transfer

  6. Luminescent Study of the Binding Interaction on 1,4-Dihydroxy-2,3-Dimethyl-9,10-Anthraquinone with Titanium Dioxide Nanoparticles

    Science.gov (United States)

    Pushpam, S.; Yamini, D.; Ramakrishnan, V.

    2014-07-01

    The photophysical properties of 1,4-dihydroxy-2,3-dimethyl-9,10-anthroquinone (DHDMAQ) in the absence and presence of titanium dioxide (TiO2) nanoparticles have been studied using UV-visible absorption spectroscopy and steady-state fluorescence spectroscopy. The fluorescence intensity of the DHDMAQ decreases as the concentration of TiO2 nanoparticles increases. The quenching is characterized by a Stern-Volmer plot, which displays a positive deviation from linearity. This could be explained by static quenching models. The Stern-Volmer quenching constant, association constant, and binding constant have been calculated. The distance between DHDMAQ and TiO2 nanoparticles has also been evaluated using Forster's theory of non-radiative energy transfer.

  7. Tandem organic light-emitting diodes with KBH4 doped 9,10-bis(3-(pyridin-3-yl)phenyl) anthracene connected to the charge generation layer.

    Science.gov (United States)

    Duan, Lian; Tsuboi, Taiju; Qiu, Yong; Li, Yanrui; Zhang, Guohui

    2012-06-18

    Tandem organic light emitting diodes (OLEDs) are ideal for lighting applications due to their low working current density at high brightness. In this work, we have studied an efficient electron transporting layer of KBH(4) doped 9,10-bis(3-(pyridin-3-yl)phenyl)anthracene (DPyPA) which is located adjacent to charge generation layer of MoO(3)/NPB. The excellent transporting property of the DPyPA:KBH(4) layer helps the tandem OLED to achieve a lower voltage than the tandem device with the widely used tris-(8-hydroxyquinoline)aluminum:Li. For the tandem white OLED with a fluorescent blue unit and a phosphorescent yellow unit, we've achieved a high current efficiency of 75 cd/A, which can be further improved to 120 cd/A by attaching a diffuser layer.

  8. A cross-sectional study of frequency and factors associated with dog walking in 9-10 year old children in Liverpool, UK.

    Science.gov (United States)

    Westgarth, Carri; Boddy, Lynne M; Stratton, Gareth; German, Alexander J; Gaskell, Rosalind M; Coyne, Karen P; Bundred, Peter; McCune, Sandra; Dawson, Susan

    2013-09-10

    Owning a pet dog could potentially improve child health through encouraging participation in physical activity, through dog walking. However, evidence to support this is limited and conflicting. In particular, little is known about children's participation in dog walking and factors that may be associated with this. The objective of this study was to describe the participation of children in dog walking, including their own and those belonging to somebody else, and investigate factors associated with regular walking with their own pet dog. Primary school children (n=1021, 9-10 years) from a deprived area of Liverpool were surveyed during a 'fitness fun day' as part of the SportsLinx project. The 'Child Lifestyle and Pets' survey included questions about pet ownership, pet attachment, and dog walking. Multivariable logistic regression models were used to investigate factors associated with walking any dog, or their own dog, several times a day or more, including level of attachment to the dog, dog type, and sociodemographic factors. Overall, 15.4% of children reported walking with any dog (their own or belonging to a friend or family member) ≥ once daily, 14.1% several times a week, 27.6% ≤ once a week, and 42.8% never. Dog owning children (37.1% of the population) more often reported dog walking 'several times a week or more' (OR=12.30, 95% CI=8.10-18.69, Ppet dogs may be an opportunity for increasing physical activity in 9-10 year old children. The identification of stronger attachment to dogs regularly walked is similar to findings in adult studies.

  9. Breast-milk intake of 9-10-mo-old rural infants given a ready-to-use complementary food in South Kivu, Democratic Republic of Congo.

    Science.gov (United States)

    Owino, Victor O; Bahwere, Paluku; Bisimwa, Ghislain; Mwangi, Christine M; Collins, Steve

    2011-06-01

    Lipid-based ready-to-use foods are currently used for infant feeding, but their potential effect on breast-milk intake is not well documented. The objective was to assess the breast-milk intake of 9-10-mo-old infants given either a ready-to-use complementary food (RUCF) paste or a standard corn-soy blend (UNIMIX) porridge in South Kivu, Democratic Republic of Congo. Infants were randomly assigned at 6 mo of age to receive either RUCF (n = 700) or UNIMIX (n = 700) for 6 mo. Breast-milk intake was measured at 9-10 mo in a subsample of 58 infants (29 from each group). Mothers received a dose of ≈30 g deuterium oxide. Predose and postdose saliva samples were collected from both mothers and infants over 2 wk. Breast-milk intake (g/d) was measured from saliva samples by using infrared spectroscopy. Mean (±SD) breast-milk intake was not significantly (P = 0.69) different between the 2 groups: RUCF (705 ± 236 g/d) and UNIMIX (678 ± 285 g/d). Mean (±SD) nonmilk oral water intakes were 338.3 ± 251.1 and 336.4 ± 227.2 g/d for RUCF and UNIMIX, respectively (P = 0.98). No differences in breast-milk intake were observed between infants consuming either RUCF or UNIMIX. The deuterium-dose-to-the-mother dilution technique is an affordable technique that we recommend for periodic evaluation of breast-milk intake in resource-poor settings. This trial is registered at controlled-trials.com as ISRCTN20267635.

  10. Excited-state intramolecular hydrogen transfer (ESIHT) of 1,8-Dihydroxy-9,10-anthraquinone (DHAQ) characterized by ultrafast electronic and vibrational spectroscopy and computational modeling

    KAUST Repository

    Mohammed, Omar F.

    2014-05-01

    We combine ultrafast electronic and vibrational spectroscopy and computational modeling to investigate the photoinduced excited-state intramolecular hydrogen-transfer dynamics in 1,8-dihydroxy-9,10-anthraquinone (DHAQ) in tetrachloroethene, acetonitrile, dimethyl sulfoxide, and methanol. We analyze the electronic excited states of DHAQ with various possible hydrogen-bonding schemes and provide a general description of the electronic excited-state dynamics based on a systematic analysis of femtosecond UV/vis and UV/IR pump-probe spectroscopic data. Upon photoabsorption at 400 nm, the S 2 electronic excited state is initially populated, followed by a rapid equilibration within 150 fs through population transfer to the S 1 state where DHAQ exhibits ESIHT dynamics. In this equilibration process, the excited-state population is distributed between the 9,10-quinone (S2) and 1,10-quinone (S1) states while undergoing vibrational energy redistribution, vibrational cooling, and solvation dynamics on the 0.1-50 ps time scale. Transient UV/vis pump-probe data in methanol also suggest additional relaxation dynamics on the subnanosecond time scale, which we tentatively ascribe to hydrogen bond dynamics of DHAQ with the protic solvent, affecting the equilibrium population dynamics within the S2 and S1 electronic excited states. Ultimately, the two excited singlet states decay with a solvent-dependent time constant ranging from 139 to 210 ps. The concomitant electronic ground-state recovery is, however, only partial because a large fraction of the population relaxes to the first triplet state. From the similarity of the time scales involved, we conjecture that the solvent plays a crucial role in breaking the intramolecular hydrogen bond of DHAQ during the S2/S1 relaxation to either the ground or triplet state. © 2014 American Chemical Society.

  11. El discurso hegemónico sobre las acciones colectivas de resistencia civil: Casos comunas 8, 9 y 13 de Medellín The Hegemonic Discourse about Collective Actions of Civil Resistance: Cases Communes 8, 9 and 13 of Medellín

    Directory of Open Access Journals (Sweden)

    Mary Luz Alzate Zuluaga

    2010-01-01

    Full Text Available En este artículo se discute la manera cómo en la prensa escrita son informadas las distintas expresiones de resistencia civil, a partir del rastreo de la información registrada en la prensa escrita local y nacional acerca de los casos de las Comunas 8, 9 y 13 de la ciudad de Medellín durante los años 2002-2006. Se busca conocer así, de qué modo han sido descritas e interpretadas dichas prácticas, cuáles son las ausencias y los aspectos subrayados con lo emitido, qué relaciones de poder se legitiman, entre otras cuestiones. Llegando a afirmar la existencia de un discurso difundido y legitimado en los medios masivos de comunicación, acorde con el orden social y político hegemónico y dominante en Colombia. Este discurso consiste en la invisibilidad de los mensajes políticos de denuncia y oposición frente a los actores armados y sus dinámicas de guerra, y también consiste en la minimización del desafío de las prácticas colectivas producidas cotidianamente en defensa de los derechos vulnerados de los habitantes de los barrios populares y en busca del reconocimiento y justicia frente a la exclusión social y política.This article discusses the way that Press reports about the different expressions of civil resistance from tracking information registered on the local and national press about the cases of Communes 8, 9 and 13 of the city of Medellín during the years 2002-2006. The intention is to know how such practices have been described and interpreted, which are the absences and emphasized aspects with the emitted information, what power relations are legitimized, among other questions. There is an affirmation of the existence of a legitimate and spread discourse on the media consistent with the social and political hegemonic order in Colombia. This discourse consist in the invisibility of the political message of denunciation and opposition to the armed actors and their war dynamics, and also consists in the minimization of

  12. "'Microsoft' Bought 'Minecraft' … Who Knows What's Going to Happen?!": A Sociocultural Analysis of 8-9-Year-Olds' Understanding of Commercial Online Gaming Industries

    Science.gov (United States)

    Willett, Rebekah

    2018-01-01

    This study investigates children's media literacy with a specific focus on socially situatedness of children's understanding of online gaming industries and related marketing. This article analyzes interviews with 8-9-year-olds and their parents in homes in the U.S.A. Rather than concentrating on developmental factors, the article uses a…

  13. Influence of different amino substituents in position 1 and 4 on spectroscopic and acid base properties of 9,10-anthraquinone moiety.

    Science.gov (United States)

    Wcisło, Anna; Niedziałkowski, Paweł; Wnuk, Elżbieta; Zarzeczańska, Dorota; Ossowski, Tadeusz

    2013-05-01

    A series of novel 1-amino and 1,4-diamino-9,10-anthraquinones, substituted with different alkyl groups, were synthesized as the result of alkylation with amino substituents. All the obtained aminoanthraquinone derivatives were characterized by NMR, IR spectroscopy and mass spectrometry. The spectroscopic properties of these compounds were determined by using UV-Vis spectroscopy in acetonitrile, and in the mixture of acetonitrile and methanol at different pH ranges. The effects of various substituents present in the newly developed anthraquinone derivatives and their ability to form hydrogen bonds between the carbonyl oxygen atom of anthraquinone moiety and nitrogen atom of N-H group in 1-aminoanthraquinone (1-AAQ) and 1,4-diaminoanthraquinone (1,4-DAAQ) were studied. Additionally, the effects of hydrogen bond formation between O-H group in hydroxyethylamino substituent and the carbonyl oxygen atom of anthraquinone were investigated. The spectroscopic behavior of the studied derivatives strongly depended on the solvent-solute interactions and the nature of solvent. The values of pKa for the new anthraquinones were determined by the combined potentiometric and spectrophotometric titration methods. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Structural and theoretical study of 1-[1-oxo-3-phenyl-(2-benzosulfonamide)-propyl amido] - anthracene-9,10-dione to be i-motif inhibitor

    Science.gov (United States)

    Vatsal, Manu; Devi, Vandna; Awasthi, Pamita

    2018-04-01

    The 1-[1-oxo-3-phenyl-(2-benzosulfonamide)-propyl amido] - anthracene-9,10-dione (BPAQ) an analogue of anthracenedione class of antibiotic has been synthesized. To characterize molecular functional groups FT-IR and FT-Raman spectrum were recorded and vibrational frequencies were assigned accordingly. The optimized geometrical parameters, vibrational assignments, chemical shifts and thermodynamic properties of title compound were computed by ab initio calculations at Density Functional Theory (DFT) method with 6-31G(d,p) as basis set. The calculated harmonic vibrational frequencies of molecule were then analysed in comparison to experimental FT-IR and Raman spectrum. Gauge independent atomic orbital (GIAO) method was used for determining, (1H) and carbon (13C) nuclear magnetic resonance (NMR) spectra of the molecule. Molecular parameters were calculated along with its periodic boundary conditions calculation (PBC) analysis supported by X-ray diffraction studies. The frontier molecular orbital (HOMO, LUMO) analysis describes charge distribution and stability of the molecule which concluded that nucleophilic substitution is more preferred and the mullikan charge analysis also confirmed the same. Further the title compound showed an inhibitory action at d(TCCCCC), an intermolecular i-motif sequence, hence molecular docking study suggested the inhibitory activity of the compound at these junction.

  15. Solvatochromism and preferential solvation of 1,4-dihydroxy-2,3-dimethyl-9,10-anthraquinone by UV-vis absorption and laser-induced fluorescence measurements

    Science.gov (United States)

    Sasirekha, V.; Vanelle, P.; Terme, T.; Ramakrishnan, V.

    2008-12-01

    Solvation characteristics of 1,4-dihydroxy-2,3-dimethyl-9,10-anthraquinone ( 1) in pure and binary solvent mixtures have been studied by UV-vis absorption spectroscopy and laser-induced fluorescence techniques. The binary solvent mixtures used as CCl 4 (tetrachloromethane)-DMF ( N, N-dimethylformamide), AN (acetonitrile)-DMSO (dimethylsulfoxide), CHCl 3 (chloroform)-DMSO, CHCl 3-MeOH (methanol), and MeOH-DMSO. The longest wavelength band of 1 has been studied in pure solvents as well as in binary solvent mixtures as a function of the bulk mole fraction. The Vis absorption band maxima show an unusual blue shift with increasing solvent polarity. The emission maxima of 1 show changes with varying the pure solvents and the composition in the case of binary solvent mixtures. Non-ideal solvation characteristics are observed in all binary solvent mixtures. It has been observed that the quantity [ ν-(Xν+Xν)] serves as a measure of the extent of preferential solvation, where ν˜ and X are the position of band maximum in wavenumbers (cm -1) and the bulk mole fraction values, respectively. The preferential solvation parameters local mole fraction ( X2L), solvation index ( δs2), and exchange constant ( k12) are evaluated.

  16. Prevention of Internalising Disorders in 9-10 year old children: Efficacy of the Aussie Optimism Positive Thinking Skills Program at 30-month follow-up

    Directory of Open Access Journals (Sweden)

    David eMorrison

    2013-12-01

    Full Text Available The Aussie Optimism: Positive Thinking Skills Program (AOPTP is a school-based prevention program aimed at addressing anxious and depressive symptoms in children aged 9-10 years. Nine-hundred and ten students from 22 Australian primary schools situated in low socio-economic areas were randomly assigned to either an intervention or control group, and assessed at a 30-month follow up. Those in the intervention group received the AOPTP program, where the control group continued to receive the regular health education course. Students completed self-report measures regarding their levels of depression, anxiety, and attribution style. Parents also reported on their children’s externalising and internalising problems outside of school. There were no significant differences between groups in regard to anxiety or depression, as well as no significant differences in attributional styles. Parents reported significantly less hyperactive behaviours from children in the intervention group. This finding suggests that AOP-PTS has the capacity to treat externalising problems at a medium term effect. The decrease in the externalising problems provides evidence of a partial medium term intervention effect. Future studies should continue to evaluate the program at a long term follow up.

  17. Proceedings of the Modeling Evidence in HPV Pre-Conference Workshop in Malmö, Sweden, May 9-10, 2009.

    Science.gov (United States)

    Craig, Benjamin M; Brisson, Marc; Chesson, Harrell; Giuliano, Anna R; Jit, Mark

    2010-08-01

    Prominent published and active human papillomavirus (HPV) modelers from around the world were invited to participate in the inaugural Modeling Evidence in HPV (MEHPV) Pre-Conference Workshop on May 9-10, 2009, in Malmö, Sweden. The workshop took place directly before the 25th International Papillomavirus Conference. The aim of the workshop was to develop an international network of investigators engaged in HPV modeling and to facilitate open discussion about the structure and parameterization of models, as well as other methodologic concerns. Thirty-four participants from more than a dozen countries and a variety of settings, representing the authors or coauthors of 82% of the HPV modeling literature, exchanged ideas on fundamental questions in the field. These proceedings, based on the 217-page transcript, were assembled by the Scientific Committee to summarize the ideas of workshop participants in a deidentified, readable fashion. They represent the work and recorded opinions of session participants and do not constitute the official positions of participants as a whole or individually, the Scientific Committee, or any sponsoring organization or entity. In charting a path forward, 3 topics emerged as most pressing: best practices for HPV modeling, comparative modeling, and modeling in developing countries. This summary of the proceedings of the preconference workshop on HPV modeling characterizes many of the prominent contemporary issues in the field. 2010 Excerpta Medica Inc. All rights reserved.

  18. Morphology-Controlled 9,10-Diphenylanthracene Nanoblocks as Electrochemiluminescence Emitters for MicroRNA Detection with One-Step DNA Walker Amplification.

    Science.gov (United States)

    Liu, Jia-Li; Tang, Zhi-Ling; Zhang, Jia-Qi; Chai, Ya-Qin; Zhuo, Ying; Yuan, Ruo

    2018-04-17

    The electrochemiluminescence (ECL) properties of polycyclic aromatic hydrocarbons (PAHs) are excellent on account of the high photoluminescence quantum yield. However, the poor solubility and radical instability of PAHs in the aqueous solution severely restricted further biological application. Here 9,10-diphenylanthracene (DPA) nanoblocks (NBs) with good dispersibility and stability in aqueous solution were prepared according to morphology-controlled technology employing water-soluble polymers as a protectant. Furthermore, an ECL "off-on" switch biosensor was developed based on a novel ECL ternary system with DPA NBs as luminophore, dissolved O 2 as coreactant, and Pt-Ag alloy nanoflowers as the coreaction accelerator, which achieved a high-intense initial ECL signal. Subsequently, the Fc-DNA as ECL signal quencher was assembled on the electrode surface to quench the initial ECL signal for a "signal-off" state. Meanwhile, DNA swing arm was modified on the electrode surface for one-step DNA walker amplification. Interestingly, in the presence of miRNA-141 and T7 Exo, the one-step DNA walker amplification was executed to recover a strong ECL signal as a "signal-on" state by the digestion of Fc-DNA. Thus the developed ECL "off-on" switch biosensor possesses a detection limit down to 29.5 aM for ultrasensitive detection of miRNA-141, which is expected to be applicable to the detection of miRNA in clinic tumor cells.

  19. Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs

    Directory of Open Access Journals (Sweden)

    Lenka Borska

    2014-01-01

    Full Text Available Some specific antibodies indicate the presence of antigenic structures on DNA (DNA adducts that can play an important role in the process of mutagenesis and/or carcinogenesis. They indicate the presence of increased genotoxic potential (hazard prior to the formation of disease (primary prevention. The present study was focused on the serum level of benzo[a]pyrene 7,8-diol-9,10-epoxide-DNA adducts antibodies (anti-BPDE-DNA in psoriatic patients (n=55 dermally exposed to different levels of polycyclic aromatic hydrocarbons (PAHs. The general goal of the study was to contribute to better understanding of the value of the assumed biomarker (anti-BPDE-DNA for evaluation of the organism's answer to genotoxic exposure to PAHs. Elevated level of exposure to PAHs resulted in the increased level of anti-BPDE-DNA. However, almost all levels of anti-BPDE-DNA ranged within the field of low values. Both variants of GT (CCT-3% and CCT-5% induced higher expression of anti-BPDE-DNA in the group of nonsmokers. Significant relations between the level of anti-BPDE-DNA and PASI score, total duration of the therapy, or time of UVR exposure were not found. Further studies are needed to reduce interpretation uncertainty of this promising bioindicator.

  20. Solution processed white light photodetector based N, N′-di (2-ethylhexyl)-3,4,9,10-perylene diimide thin film phototransistor

    Energy Technology Data Exchange (ETDEWEB)

    Tozlu, Cem, E-mail: tozlu.cem@gmail.com [Department of Energy System Engineering, Faculty of Engineering, Karamanoğlu Mehmetbey University, 70100 Karaman (Turkey); Kus, Mahmut [Department of Chemical Engineering, Selcuk University, Konya 42075 (Turkey); Advanced Technology Research and Application Center, Selcuk University, Konya 42075 (Turkey); Can, Mustafa [Department of Engineering Sciences, Faculty of Engineering, Izmir Katip Celebi University, Cigli, 35620 Izmir (Turkey); Ersöz, Mustafa [Advanced Technology Research and Application Center, Selcuk University, Konya 42075 (Turkey); Department of Chemistry, Selcuk University, Konya 42075 (Turkey)

    2014-10-31

    In this study, a solution-processed n-type photo-sensing organic thin film transistor was investigated using polymeric dielectric under different white light illuminations. N, N′-di (2-ethylhexyl)-3,4,9,10-perylene diimide and divinyl tetramethyl disiloxane-bis (benzo-cyclobutene) were used as a soluble active organic semiconductor and as a dielectric material, respectively. Stable amplification was observed in the visible region without gate bias by the device. The electrical characterization results showed that an n-type phototransistor with a saturated electron mobility of 0.6 × 10{sup −3} cm{sup 2}/V·s and a threshold voltage of 1.8 V was obtained. The charge carrier density of the channel of the device exhibited photo-induced behaviors that strongly affected the electrical properties of the transistor. The photosensitivity and photoresponsivity values of the device were 63.82 and 24 mA/W, respectively. These findings indicate that perylene diimide is a promising material for use on organic based phototransistors. - Highlights: • A solution processed n-type organic phototransistor was fabricated. • The geometry of device allows to be used double sided photo-sensor to detect light. • The accumulation of charge carrier is effected strongly by illumination intensity. • The current amplification was observed clearly under illumination without gate bias.

  1. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts.

    Directory of Open Access Journals (Sweden)

    Parvathi Chary

    Full Text Available To aid in the characterization of the relationship of structure and function for human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT, this investigation utilized DNAs containing benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE-modified primers and templates as a probe of the architecture of this complex. BPDE lesions that differed in their stereochemistry around the C10 position were covalently linked to N (6-adenine and positioned in either the primer or template strand of a duplex template-primer. HIV-1 RT exhibited a stereoisomer-specific and strand-specific difference in replication when the BPDE-lesion was placed in the template versus the primer strand. When the C10 R-BPDE adduct was positioned in the primer strand in duplex DNA, 5 nucleotides from the 3΄ end of the primer terminus, HIV-1 RT could not fully replicate the template, producing truncated products; this block to further synthesis did not affect rates of dissociation or DNA binding affinity. Additionally, when the adducts were in the same relative position, but located in the template strand, similar truncated products were observed with both the C10 R and C10 S BPDE adducts. These data suggest that the presence of covalently-linked intercalative DNA adducts distant from the active site can lead to termination of DNA synthesis catalyzed by HIV-1 RT.

  2. Determination of the individual atomic site contribution to the electronic structure of 3,4,9,10-perylene-tetracarboxylic-dianhydride (PTCDA)

    Energy Technology Data Exchange (ETDEWEB)

    Cho, S. W., E-mail: dio8027@yonsei.ac.kr, E-mail: ksmith@bu.edu [Department of Physics, Yonsei University, Wonju, Gangwon-do 220-710 (Korea, Republic of); Newby, D.; DeMasi, A.; Smith, K. E., E-mail: dio8027@yonsei.ac.kr, E-mail: ksmith@bu.edu [Department of Physics, Boston University, 590 Commonwealth Ave., Boston, Massachusetts 02215 (United States); Piper, L. F. J. [Department of Physics, Applied Physics, and Astronomy, Binghamton University, State University of New York, Binghamton, New York 13902 (United States); Jones, T. S. [Department of Chemistry, University of Warwick, Coventry CV4 7AL (United Kingdom)

    2013-11-14

    We have studied the element and orbital-specific electronic structure of thin films of 3,4,9,10-perylene-tetracarboxylic-dianhydride (PTCDA) using a combination of synchrotron radiation-exited resonant x-ray emission spectroscopy, x-ray absorption spectroscopy, x-ray photoelectron spectroscopy, as well as density functional theory calculations. Resonant and non-resonant x-ray emission spectroscopies were used to measure the C and O 2p partial densities of state in PTCDA. Furthermore, resonant x-ray emission at the C and O K-edges is shown to be able to measure the partial densities of states associated with individual atomic sites. The flat molecular orientation of PTCDA on various substrates is explained in terms of the carbonyl O atom acting as a hydrogen-bond acceptor leading to multiple in-plane intermolecular C=O···H−C hydrogen bonding between carbonyl groups and the perylene core of the neighboring PTCDA molecules. We support this conclusion by comparison of our calculations to measurements of the electronic structure using element-, site-, and orbital-selective C and O K-edge resonant x-ray emission spectroscopy, and photoemission spectroscopy.

  3. Creep behaviour of the alloys NiCr22Co12Mo and 10CrMo9 10 under static and cyclic load conditions

    International Nuclear Information System (INIS)

    Wolf, H.

    1990-01-01

    The creep behaviour of NiCr20Co12Mo is investigated under static strain and at 800deg C, with stresses applied ranging from 105 MPa to 370 MPa. The ferritic steel 10CrMo 9 10 is tested for its creep behaviour under static strain and at the temperatures of 600deg C and 550deg C, with stresses applied between 154 MPa and 326 MPa (at 600deg C), or between 250 MPa and 458 MPa (at 550deg C). The experiments are made to determine the effects of changes in strain on the materials' deformation behaviour, placing emphasis on transient creep and elastic or anelastic response. The mean internal stress is determined from changes in strain. Cyclic creep is analysed as a behaviour directly responding to the pattern of change in strain. Effects of certain strain changes not clarified so far are analysed. The cyclic strain experiments are analysed according to the velocity factor concept. The usual models of creep deformation (theta projection concept) are compared with the model of effective strain, which is based on the fundamental equation of plastic deformation by dislocation motion (Orowan equation). (MM) [de

  4. 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate induced autophagic cell death in human PC3 cells.

    Science.gov (United States)

    Huang, A-Mei; Lin, Kai-Wei; Lin, Wei-Hong; Wu, Li-Hung; Chang, Hao-Chun; Ni, Chujun; Wang, Danny Ling; Hsu, Hsue-Yin; Su, Chun-Li; Shih, Chiaho

    2018-02-01

    The autophagy of human prostate cancer cells (PC3 cells) induced by a new anthraquinone derivative, 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate (PA) was investigated, and the relationship between autophagy and reactive oxygen species (ROS) generation was studied. The results indicated that PA induced PC3 cell death in a time- and dose-dependent manner, could inhibit PC3 cell growth by G1 phase cell cycle arrest and corresponding decrease in the G2/M cell population and induced S-phase arrest accompanied by a significant decrease G2/M and G1 phase numbers after PC3 cells treated with PA for 48 h, and increased the accumulation of autophagolysosomes and microtubule-associated protein LC3-ll, a marker of autophagy. However, these phenomenon were not observed in the group pretreated with the autophagy inhibitor 3-MA or Bafilomycin A1 (BAF), suggesting that PA induced PC3 cell autophagy. In addition, we found that PA triggered ROS generation in cells, while the levels of ROS decreased in the N-acetylcysteine (NAC) co-treatment, indicating that PA-mediated autophagy was partly blocked by NAC. In summary, the autophagic cell death of human PC3 cells mediated by PA-triggered ROS generation. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Fluorescence quenching of N,N-bis(2,5-di-tert-butylphenyl)-3,4:9,10-perylenebis(dicarboximide) (DBPI) by silver nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    El-Daly, Samy A., E-mail: samyeldaly@yahoo.com [Chemistry Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589 (Saudi Arabia); Chemistry Department, Faculty of Science, Tanta University, Tanta 2173 (Egypt); Rahman, Mohammed M. [Chemistry Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589 (Saudi Arabia); Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, PO Box 80203, Jeddah 21589 (Saudi Arabia); Alamry, Kahlid A. [Chemistry Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589 (Saudi Arabia); Asiri, Abdullah M. [Chemistry Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589 (Saudi Arabia); Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, PO Box 80203, Jeddah 21589 (Saudi Arabia)

    2014-04-15

    The interaction of a perylene derivative namely N,N-bis(2,5-di-tert-butylphenyl)-3,4:9,10-perylenebis(dicarboximide) (DBPI) with colloidal silver nanoparticles (AgNPs) was studied in ethanol and ethylene glycol using steady state fluorescence quenching measurements. The Stern–Volmer quenching rate constant (K{sub sv}) was calculated as 4.03×10{sup 9} and 29.14×10{sup 9} M{sup −1} in ethanol and ethylene glycol, respectively. From fluorescence quenching data, static quenching and energy transfer play a major role in the fluorescence quenching of DBPI by AgNPs. The apparent association constant (k{sub app}) was calculated as 1.26×10{sup 8} M{sup −1} in EtOH and 1.83×10{sup 9} M{sup −1} in ethylene glycol. Due to potential AgNPs interaction with DBPI, the average AgNPs size is increased slightly from ∼37.1 nm (As-prepared) to 48.9 nm. -- Highlights: • Fluorescence quenching of photostable DBPI by AgNPs. • Static quenching mechanism of interaction between DBPI and AgNPs. • Enhancement of fluorescence quenching of DBPI in ethylene glycol.

  6. Ground and excited state behavior of 1,4-dimethoxy-3-methyl-anthracene-9,10-dione in silver nanoparticles: Spectral and computational investigations

    Energy Technology Data Exchange (ETDEWEB)

    Umadevi, M., E-mail: ums10@yahoo.com [Department of Physics, Mother Teresa Women' s University, Kodaikanal 624101, Tamil Nadu (India); Kavitha, S.R. [Department of Physics, Mother Teresa Women' s University, Kodaikanal 624101, Tamil Nadu (India); Vanelle, P.; Terme, T.; Khoumeri, O. [Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix-Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05 (France)

    2013-10-15

    Silver nanoparticles (Ag NPs) of various sizes have been successfully synthesized by the simple and convenient Creighton method using sodium borohydride as the reducing agent under microwave irradiation. Optical absorption and fluorescence emission spectroscopic techniques were employed to investigate the effect of silver nanoparticles on the ground and excited state of 1,4-dimethoxy-3-methylanthracene-9,10-dione (DMMAD). The surface plasmon resonance (SPR) peak of the prepared silver colloidal solution was observed at 400 nm. Fluorescence quenching of DMMAD by silver nanoparticles has been found to increase with increase in the size of Ag. The fluorescence quenching has been explained by Forster Resonance Energy Transfer (FRET) theory between DMMAD and silver nanoparticles. The Stern–Volmer quenching constant and Benesi–Hildebrand association constant for the above system were calculated. DFT calculations were also performed to study the charge distribution of DMMAD in Ag both in ground and excited states. -- Highlights: • Silver nanoparticles (Ag NPs) have been synthesized using the Creighton method. • Effect of Ag NPs on the ground state of DMMAD was studied. • Influence of Ag NPs on the excited state of DMMAD was investigated. • Fluorescence quenching has been explained by Forster Resonance Energy Transfer. • Quenching and binding constants were also calculated.

  7. TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide

    International Nuclear Information System (INIS)

    Zhang Lijuan; Huang He; Deng Luyao; Chu Ming; Xu Lan; Fu Juanling; Zhu Yunlan; Zhang Xiuchun; Liu Shulin; Zhou Zongcan; Wang Yuedan

    2008-01-01

    In order to elucidate the function of the targeting protein for Xenopus kinesin-like protein 2 (Xklp2) (TPX2) in the malignant transformation of human bronchial epithelial cells induced by anti-benzo[a]pyrene-trans-7, 8-dihydrodiol-9, 10-epoxide (anti-BPDE), TPX2 was characterized in cells at both the gene and the protein levels. TPX2 was present at higher levels in 16HBE-C cells than in 16HBE cells as demonstrated by two-dimensional gel electrophoresis, immunocytochemistry, Western blot analysis and RT-PCR. TPX2 was also detected in lung squamous-cell carcinoma tissues by immunohistochemistry, but not in normal lung tissues. Depression of TPX2 by RNA interference in 16HBE-C cells led to a decrease in cell proliferation, S-phase cell cycle arrest and cell apoptosis. Abnormal TPX2 tyrosine phosphorylation was detected in 16HBE-C cells, and this could be inhibited, to different degrees, by tyrosine kinase inhibitors. Inhibiting tyrosine phosphorylation in 16HBE-C cells by three selected tyrosine protein kinase inhibitors, tyrphostin 47, AG112 and AG555, caused G 0 /G 1 -phase cell cycle arrest. Our results suggest that anti-BPDE can cause the over-expression of TPX2 and its aberrant tyrosine phosphorylation. Misregulation of TPX2 affects the cell cycle state, proliferation rates and apoptosis

  8. Food and drink consumption at school lunchtime: the impact of lunch type and contribution to overall intake in British 9-10-year-old children.

    Science.gov (United States)

    Harrison, Flo; Jennings, Amy; Jones, Andy; Welch, Ailsa; van Sluijs, Esther; Griffin, Simon; Cassidy, Aedín

    2013-06-01

    To examine the differences in dietary intakes of children consuming school meals and packed lunches, the contribution of lunchtime intake to overall dietary intake, and how lunchtime intake relates to current food-based recommendations for school meals. Cross-sectional analysis of overall intake of macronutrients and food choice from 4 d food diaries and school lunchtime intake from the two diary days completed while at school. Norfolk, UK. One thousand six hundred and twenty-six children (aged 9-10 years) attending ninety Norfolk primary schools. At school, lunchtime school meal eaters consumed more vegetables, sweet snacks, chips, starchy foods and milk, and less squash/cordial, fruit, bread, confectionery and savoury snacks than packed lunch eaters. These differences were also reflected in the overall diet. On average school meal eaters met the School Food Trust (SFT) food-based standards, while food choices among packed lunch eaters were less healthy. The contribution of food consumed at school lunchtime to overall diet varied by food and lunch type, ranging from 0.8 % (milk intake in packed lunches) to 74.4 % (savoury snack intake in packed lunches). There were significant differences in the foods consumed by school meal and packed lunch eaters, with food choices among school meal eaters generally in line with SFT standards. The food choices made at school lunchtime make a significant contribution to overall diet.

  9. Selected Lectures of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2018-03-01

    Full Text Available Selected Lectures of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018 CONGRESS PRESIDENT Paolo Biban  Guest Editor: Paolo BibanLECT 1. RESUSCITATION OF EXTREMELY PREMATURE INFANTS: HOW TO IMPROVE EVEN FURTHER • J.M. PerlmanLECT 2. MAINTAINING NORMAL TEMPERATURE IN THE NEWLY BORN: NOT A TRIVIAL GAME • J. WyllieLECT 3. PRESENT AND FUTURE OF SURFACTANT AD­MINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS • A. KribsLECT 4. CONTINUOUS POSITIVE AIRWAY PRES­SURE (CPAP, SURFACTANT, OR BOTH? A DILEMMA STILL WAITING TO BE SOLVED • D. De LucaLECT 5. NON-INVASIVE RESPIRATORY SUPPORT AND RESPIRATORY DISTRESS SYNDROME (RDS: IS NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE (nCPAP ALWAYS ENOUGH? • G. Lista, I. BresestiLECT 6. NEURALLY ADJUSTED VENTILATORY ASSIST (NAVA IN THE NEWBORN: A NEW STANDARD OF CARE? • H. SteinLECT 7. HIGH-FREQUENCY, MULTI-FREQUENCY OSCIL­LA­TION, JET VENTILATION: WHERE ARE WE? • J.J. PillowLECT 8. SURVIVAL AND NEURODEVELOPMENTAL OUT­COME IN PERIVIABLE INFANTS • N. YoungeLECT 9. PATHOPHYSIOLOGY AND TREATMENT OF SEPTIC SHOCK IN NEONATES • H.R. WongLECT 10. CLINICAL METABOLOMICS IN NEONATAL SEPSIS • V. FanosLECT 11. OPTIMIZING EARLY NUTRITION SUPPORT IN VERY LOW BIRTH WEIGHT (VLBW INFANTS • T. SenterreLECT 12. LONG-TERM ADVERSE EFFECTS OF EARLY GROWTH ACCELERATION OR CATCH-UP GROWTH • A. SinghalLECT 13. ROLE OF NEAR INFRARED SPECTROSCOPY DURING NEONATAL TRANSITION • B. UrlesbergerLECT 14. HEART RATE CHARACTERISTICS AS PHYSIO­MARKERS FOR DETECTION OF SEPSIS AND OTHER DISEASES • K.D. FairchildLECT 15. ENHANCED CARDIORESPIRATORY MONI­TORING OF THE PRETERM INFANT DURING STABILIZA­TION IN THE DELIVERY ROOM • E. Dempsey

  10. Exciton dynamics at the heteromolecular interface between N,N′-dioctyl-3,4,9,10-perylenedicarboximide and quaterrylene, studied using time-resolved photoluminescence

    Directory of Open Access Journals (Sweden)

    Nobuya Hiroshiba

    2014-06-01

    Full Text Available To elucidate the exciton dynamics at the heteromolecular interface, the temperature dependence of time-resolved photoluminescence (TRPL spectra of neat-N,N′-dioctyl-3,4,9,10-perylenedicarboximide (PTCDI-C8 and PTCDI-C8/Quaterrylene (QT heteromolecular thin films was investigated. The lifetimes of excitons were evaluated to identify the Frenkel (FE, high energy charge-transfer (CTEhigh, low energy charge-transfer (CTElow, and excimer exciton states. The thermal activation energy (Δact of CTElow in PTCDI-C8 thin film was evaluated as 25 meV, which is 1/5 of that of FE, indicating that CTElow is more thermally sensitive than FE in PTCDI-C8 thin film. We investigated the exciton transport length (l along the vertical direction against the substrate surface in PTCDI-C8/QT thin film at 30 K, and demonstrated that lFE = 9.9 nm, lCTElow = 4.2 nm, lCTEhigh = 4.3 nm, and lexcimer = 11.9 nm. To elucidate the difference in l among these excitons, the activation energies (Ea for quenching at the heteromolecular interface were investigated. Ea values were estimated to be 13.1 meV for CTElow and 18.6 meV for CTEhigh. These values agree with the thermal sensitivity of CTEs as reported in a previous static PL study. This latter situation is different from the case of FE and excimer excitons, which are transported via a resonant process and have no temperature dependence. The small Ea values of CTEs suggest that exciton transport takes place via a thermal hopping process in CTEs. The present experimental study provides information on nano-scaled exciton dynamics in a well-defined PTCDI-C8 (2 ML/QT (2 ML system.

  11. Efficacy of krypton laser photodynamic therapy for oral mucosa dysplasia in 9,10-dimethyl-1,2-benzanthracene-treated hamsters.

    Science.gov (United States)

    Shen, Lingyue; Xu, Qing; Li, Pingping; Zhou, Guoyu

    2013-11-01

    The present study aimed to evaluate the efficacy of krypton laser photodynamic therapy (PDT) with PsD-007 for the treatment of oral mucosa dysplasia in 9,10-dimethyl-1,2-benzanthracene (DMBA)-treated hamsters. A DMBA-induced hamster cheek pouch model of precancerous lesions was created and the resultant 25 hamsters were divided into five groups. The right side was treated with PDT and the left side was used as the positive control. Following systemic anesthesia, an incision was made in the groin area to expose the femoral vein. PsD-007 was administered intravenously through the femoral vein. Various doses of photosensitizer were used to treat groups A-E. Subsequent to closing the incision, the right side of the buccal mucosa was irradiated with light using the krypton laser at a wavelength of 413 nm, a power density of 150 mW/cm 2 and an irradiation time of 20 min. At six weeks post-surgery, the response was analyzed using histological examinations of the buccal pouch mucosa. A total of 24 hamsters completed the six-week observation period, as one hamster from group C died in the second week following the PDT. Of all 24 irradiated sides, 15 formed normal mucosal tissues and nine demonstrated mild dysplasia. Of the total control sides, six developed moderate dysplasia, five developed severe dysplasia and 13 progressed to carcinoma in situ or squamous cell carcinoma (SCC). The results revealed a significant difference between the two sides (P10 mg/kg, there was no statistical difference (P>0.05). PsD-007-mediated krypton laser PDT is effective for the treatment of oral mucosa dysplasia in hamsters.

  12. TR-ESR Investigation on Reaction of Vitamin C with Excited Triplet of 9,10-phenanthrenequinone in Reversed Micelle Solutions

    Science.gov (United States)

    Xu, Xin-sheng; Shi, Lei; Liu, Yi; Ji, Xue-han; Cui, Zhi-feng

    2011-04-01

    Time-resolved electron spin resonance has been used to study quenching reactions between the antioxidant Vitamin C (VC) and the triplet excited states of 9,10-phenanthrenequinone (PAQ) in ethylene glycol-water (EG-H2O) homogeneous and inhomogeneous reversed micelle solutions. Reversed micelle solutions were used to be the models of physiological environment of biological cell and tissue. In PAQ/EG-H2O homogeneous solution, the excited triplet of PAQ (3PAQ*) abstracts hydrogen atom from solvent EG. In PAQ/VC/EG-H2O solution, 3PAQ* abstracts hydrogen atom not only from solvent EG but also from VC. The quenching rate constant of 3PAQ* by VC is close to the diffusion-controlled value of 1.41 × 108 L/(mol ·s). In hexadecyltrimethylammonium bromide (CTAB)/EG-H2O and aerosol OT (AOT)/EG-H2O reversed micelle solutions, 3PAQ* and VC react around the water-oil interface of the reversed micelle. Exit of 3PAQ* from the lipid phase slows down the quenching reaction. For Triton X-100 (TX-100)/EG-H2O reversed micelle solution, PAQ and VC coexist inside the hydrophilic polyethylene glycol core, and the quenching rate constant of 3PAQ* by VC is larger than those in AOT/EG-H2O and CTAB/EG-H2O reversed micelle solutions, even a little larger than that in EG-H2O homogeneous solution. The strong emissive chemically induced dynamic electron polarization of As.- resulted from the effective TM spin polarization transfer in hydrogen abstraction of 3PAQ* from VC.

  13. EFEK INTERVENSI PENDIDIKAN BERBASIS SEKOLAH TERHADAP TINGKAT PENGETAHUAN TENTANG PENCEHAGAN KEGEMUKAN DI ANTARA ANAK-ANAK USIA 9-10 TAHUN Di KOTA BANDUNG

    Directory of Open Access Journals (Sweden)

    Hermina Hermina

    2012-11-01

    Full Text Available Effect of School-Based Educational Interventions On The Level of Obesity Prevention's Knowledge Among 9-10 Year-Old Children In Bandung City.Background: The prevalence of obesity in Indonesia shows an increasing trend. A survey among adults in 12 major cities in Indonesia shows the prevalence of obesity in adult is more then 20%. The prevalence among school age children is 6.0%. Obesity in childhood is known to be an independent risk factor for adult obesity.Objectives: To assess the effect of school-based educational intervention on the level of obesity prevention's knowledge, among elementary school-aged children.Methods: This study having non-control group pre- and post-test design was based in three Bandung's Elementary Schools in 112 children aged 9 to 10 years. The three schools were selected from six Bandung's Elementary Schools having both high socio-economic status and more obese children based on the Office of Basic Education. The intervention schools drawn from SDN M5 included 39 children gave the Obesity Prevention's booklet by their teacher for their parent (Group A, SD P1 36 children gave the booklet for themselves (Group B, and SD P2 37 children gave the booklet for their parent and themselves (Group C. All children were measured their weight and height and were interviewed using structured questionnaire that covered their characteristics and the five topics about obesity (definition, causes, consequences, how to identify, and how to weight control. Data were analyzed descriptively and tested by Chi-square and t-tests.Results: At baseline, most of children (>90% had less of knowledge in the obesity prevention. After intervention, only the Group B & C had significantly increase in the knowledge (p<0.05. However, between the two groups, the Group C was more effective in increasing the knowledge.Conclusion: Educational intervention giving the Obesity Prevention's booklet by teacher to school children and their parents was more

  14. 1,5-Diamido-9,10-anthraquinone, a Centrosymmetric Redox-Active Bridge with Two Coupled β-Ketiminato Chelate Functions: Symmetric and Asymmetric Diruthenium Complexes.

    Science.gov (United States)

    Ansari, Mohd Asif; Mandal, Abhishek; Paretzki, Alexa; Beyer, Katharina; Fiedler, Jan; Kaim, Wolfgang; Lahiri, Goutam Kumar

    2016-06-06

    The dinuclear complexes {(μ-H2L)[Ru(bpy)2]2}(ClO4)2 ([3](ClO4)2), {(μ-H2L)[Ru(pap)2]2}(ClO4)2 ([4](ClO4)2), and the asymmetric [(bpy)2Ru(μ-H2L)Ru(pap)2](ClO4)2 ([5](ClO4)2) were synthesized via the mononuclear species [Ru(H3L)(bpy)2]ClO4 ([1]ClO4) and [Ru(H3L)(pap)2]ClO4 ([2]ClO4), where H4L is the centrosymmetric 1,5-diamino-9,10-anthraquinone, bpy is 2,2'-bipyridine, and pap is 2-phenylazopyridine. Electrochemistry of the structurally characterized [1]ClO4, [2]ClO4, [3](ClO4)2, [4](ClO4)2, and [5](ClO4)2 reveals multistep oxidation and reduction processes, which were analyzed by electron paramagnetic resonance (EPR) of paramagnetic intermediates and by UV-vis-NIR spectro-electrochemistry. With support by time-dependent density functional theory (DFT) calculations the redox processes could be assigned. Significant results include the dimetal/bridging ligand mixed spin distribution in 3(3+) versus largely bridge-centered spin in 4(3+)-a result of the presence of Ru(II)-stabilizig pap coligands. In addition to the metal/ligand alternative for electron transfer and spin location, the dinuclear systems allow for the observation of ligand/ligand and metal/metal site differentiation within the multistep redox series. DFT-supported EPR and NIR absorption spectroscopy of the latter case revealed class II mixed-valence behavior of the oxidized asymmetric system 5(3+) with about equal contributions from a radical bridge formulation. In comparison to the analogues with the deprotonated 1,4-diaminoanthraquinone isomer the centrosymmetric H2L(2-) bridge shows anodically shifted redox potentials and weaker electronic coupling between the chelate sites.

  15. Let's do comprehension 8-9

    CERN Document Server

    Brodie, Andrew

    2015-01-01

    Let's Do Comprehension is a brand new series of six titles in the popular 'Let's Do' range. Each book contains a rich variety of stimulating reading passages, accompanied by questions of varying difficulty. Designed to be used at home, each book includes tips and clues from Alice the Alligator as well as extra challenges in Brodie's Brain Boosters. There is a clear answer section for reference by parents and children, together with bright, colourful reward stickers.

  16. Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2018-03-01

    Full Text Available Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018CONGRESS PRESIDENTPaolo Biban  Guest Editor: Paolo BibanABS 1. DOES DELAYED CORD CLAMPING (DCC AFFECT UMBILICAL CORD pH IN PRETERM INFANTS? • V.M. Samedi, L. Irvine, S. Thomas, D. Kowal, J. Rabi, A. Stritzke, N. Singhal, A. Abou MehremABS 2. SNAP-PE SCORE. MORBIDITY AND MOR­TALI­TY INDEX IN NICUs • A. Konstantinidi, R. Sokou, S. Parastatidou, A. Tsantes, N. IacovidouABS 3. EARLY PERINATAL INTERVENTIONS IM­PROVES NEONATAL OUTCOMES • A. Ansary, R. Lee, S. KinmondABS 4. DILATED CARDIOMYOPATHY AND VITAMIN D DEFICIENCY: CASE REPORT IN A PRETERM INFANT • A. Proto, S. Fiocchi, I. Gatelli, L. Ilardi, S. MartinelliABS 5. SURVEY ON PERINATAL PALLIATIVE CARE ACROSS ITALY: PRELIMINARY RESULTS • M.E. Cavicchiolo, F. Rusalen, F. Benini, P. LagoABS 6. PLASMA ERYTHROPOIETIN AND FETO-NEONATAL ASPHYXIA IN TERM AND PRETERM NEWBORNS • F. Dituri, L. Orfeo, A. Di PaoloABS 7. A CHALLENGING CASE OF CONGENITAL INFANTILE FIBROSARCOMA • A. Ganarin, F. DeCorti, P. Dall’Igna, N. Doglioni, A. Berizzi, G. Bisogno, E. Baraldi, P.G. GambaABS 8. BIRTH ASPHYXIA IN LIMITED-RESOURCE SETTINGS: ASSOCIATED FACTORS AND OUT­COMES IN RURAL AFGHANISTAN • R. Baiocchi, M. Usuelli, P. Crosignani, E. Bruni, K. Picucci, M. Valenti, M. Langer, G. StradaABS 9. NEONATAL HEMORRHAGE FOLLOWING MA­TER­NAL LOW MOLECULAR WEIGHT HEPA­RIN (LMWH ADMINISTRATION • A. Konstantinidi, R. Sokou, S. Parastatidou, G. Patsouras, E. Isaakidou, K. Lampropoulou, K. Adamopoulos, A. Tsantes, N. IacovidouABS 10. NEONATAL/INFANTILE PINOCYTOSIS. AN UN­USU­AL CASE OF HAEMOLYTIC ANEMIA • R. Sokou, G. Patsouras, K. Lampropoulou, E. Tavoulari, K. Adamopoulos, M. Theodoraki, M. Kollia, A. KonstantinidiABS 11. THROMBOCYTOSIS IN NEONATES WITH NEONATAL ABSTINENCE SYNDROME THAT WERE HOSPITALIZED AT THE NICU OF GENERAL HOSPITAL OF NIKAIA • R. Sokou, E. Isaakidou, G. Patsouras, K

  17. Ocena występowania wad stóp u dzieci w wieku 9-10 lat w środowisku miejskim i wiejskim = Estimate the prevalence the feet defects in children aged 9-10 years in the urban and rural environment

    Directory of Open Access Journals (Sweden)

    Anna Plaskiewicz

    2015-04-01

    3 Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego w Bydgoszczy   Streszczenie   Wstęp. Wady stóp u dzieci są powszechnym problemem medyczno–społecznym w Polsce i na Świecie. Styl i szybkie tempo życia współczesnego człowieka wpływają niekorzystnie na postawę ciała, a stopy są szczególnie narażone na niekorzystny wpływ działania czynników środowiska zewnętrznego. Cel pracy. Celem pracy jest ocena występowania wad stóp u dzieci w wieku 9-10 lat w środowisku miejskim i wiejskim. Materiał i metody. Badaniami objęto grupę 40 dzieci w wieku 9-10 lat. Ze względu na miejsce zamieszkania dzieci podzielono na dwie grupy. Analizę stóp wykonano metodą platurograficzną polegającą na sporządzeniu odcisków podporowej powierzchni stopy. Oceniano wskaźniki opisujące wady stóp tj: wskaźnik „Ky” Sztritera-Godunowa, wskaźnik kątowy Clarke’a (CI, wskaźnik Wejsfloga, kąt piętowy oraz kąt koślawości palucha. Wyniki. Wśród przebadanych dzieci najczęstszą wadą stóp było płaskostopie. Zaobserwowano minimalnie mniej wad stóp u dzieci ze wsi w porównaniu z dziećmi mieszkającymi w mieście, jednak różnice nie są istotne statystycznie. Nie zaobserwowano różnic związanych z występowaniem wad stóp pomiędzy dziećmi ze wsi i z miasta. Wnioski. 1. Większość dzieci zarówno z miasta (65% jak i ze wsi (75% ma prawidłowo ukształtowane stopy. 2. Najczęstszą wadą stóp występującą wśród przebadanych dzieci jest płaskostopie. 3. Nie zaobserwowano istotnych różnic statystycznych w ocenie stóp pomiędzy dziećmi mieszkającymi w środowisku miejskim i wiejskim.   Abstract   Introduction. Feet defects in children is a common socio-medical problem in Poland and the world. Lifestyle of modern man adversely affect posture. The feet are particularly vulnerable to the adverse effects factors the external environment. Aim of the study. The aim of the study is to estimate the

  18. The Effect of Heat Treatment Parameters on Mechanical Characteristics of 10CrMo9-10 Steel Tube Bends / Wpływ Parametrów Obróbki Cieplnej Na Charakterystyki Mechaniczne Łuków Rurowych Ze Stali 10CrMo9-10

    Directory of Open Access Journals (Sweden)

    Cieśla M.

    2015-12-01

    Full Text Available The purpose of the paper was to analyse the effect of diverse heat treatment parameters (normalising and tempering on mechanical characteristics of the material used to develop ϕ508x20 tube bends made of the 10CrMo9-10 steel by application of induction heating. The research conducted included tests of basic mechanical properties as well as low cycle fatigue and creep at the temperature of 500°C. With reference to the results thus obtained, it has been established that there is a relationship between mechanical properties of bends and individual features of their microstructure conditional to the heat treatment parameters. Among other conclusions drawn in the research, it has been found that the main structural factor conditioning the mechanical properties of bends was the grain size. Heat treatment parameters characterised by lower temperature and shorter tempering time triggered changes in the material microstructure, such as increased grain comminution. The effects of the said changes included improvement of strength characteristics (Rm, Rp0,2 as well as increased material durability under conditions of fatigue and creep. Main criterion-specific mechanical properties and geometric features of the bends developed conformed with the relevant requirements of reference standards (PN-EN 10216-2, PN-EN 12952.

  19. Use of reversed-phase gel partition chromatography for the purification of chemically synthesized (5,6,8,9,11,12,14,15(n)) octadeuterium- and octatritium-labelled arachidonic acid

    Energy Technology Data Exchange (ETDEWEB)

    Wollard, P M; Lascelles, P T [Department of Chemical Pathology, Institute of Neurology, London, Great Britain; Hensby, C N [Hammersmith Hospital, London (UK). Postgraduate Medical School

    1978-12-11

    The development of a method is described for the preparation and purification of (5,6,8,9,11,12,14,15(n)-/sup 2/H)arachidonic acid (/sup 2/H/sub 8/-AA). The /sup 2/H/sub 8/-AA was chemically synthesised by the selective reduction of 5,8,11,14-eiconsatetraynoic acid (ETYA) with deuterium gas. Using reversed-phase partition chromatography on a Lipidex 5000 column support, it was shown that: (1) The reaction products could readily be separated from each other to yield /sup 2/H/sub 8/-AA of greater than 98% mass purity by gas chromatography. (2) Closely related C20 cis-ethylenic fatty acids differing only in the degree of unsaturation are efficiently separated. The resolution increases exponentially on saturation of double bonds. (3) Commercially available (5,6,8,9,11,12,14,15(n))octatritium-labelled arachidonic acid (/sup 3/H/sub 8/-AA) was readily purified. Both (/sup 3/H/sub 8/)- and (1-/sup 14/C)arachidonic acid (/sup 14/C-AA) co-chromatographed with /sup 2/H/sub 8/-AA. (4) The mass spectra of the methyl ester and trimethylsilyl ester of the purified /sup 2/H/sub 8/-AA showed molecular ions at m/e 326 and 384, respectively.

  20. In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition.

    Science.gov (United States)

    Balachandran, C; Emi, N; Arun, Y; Yamamoto, N; Duraipandiyan, V; Inaguma, Yoko; Okamoto, Akinao; Ignacimuthu, S; Al-Dhabi, N A; Perumal, P T

    2016-04-05

    The present study investigated the anticancer activity of 2,3-dihydroxy-9,10-anthraquinone against different cancer cells such as MCF-7, COLO320, HepG-2, Skov-3, MOLM-14, NB-4, CEM, K562, Jurkat, HL-60, U937, IM-9 and Vero. 2,3-dihydroxy-9,10-anthraquinone showed good antiproliferative activity against COLO320 cells when compared to other tested cells. The cytotoxicity results showed 79.8% activity at the dose of 2.07 μM with IC50 value of 0.13 μM at 24 h in COLO320 cells. So we chose COLO320 cells for further anticancer studies. mRNA expression was confirmed by qPCR analysis using SYBR green method. Treatment with 2,3-dihydroxy-9,10-anthraquinone was found to trigger intrinsic apoptotic pathway as indicated by down regulation of Bcl-2, Bcl-xl; up regulation of Bim, Bax, Bad; release of cytochrome c and pro-caspases cleaving to caspases. Furthermore, 2,3-dihydroxy-9,10-anthraquinone stopped at G0/G1 phase with modulation in protein levels of cyclins. On the other hand PI3K/AKT signaling plays an important role in cell metabolism. We found that 2,3-dihydroxy-9,10-anthraquinone inhibits PI3K/AKT activity after treatment. Also, COX-2 enzyme plays a major role in colorectal cancer. Our results showed that the treatment significantly reduced COX-2 enzyme in COLO320 cells. These results indicated antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone involving apoptotic pathways, mitochondrial functions, cell cycle checkpoint and controlling the over expression genes during the colorectal cancer. Molecular docking studies showed that the compound bound stably to the active sites of Bcl-2, COX-2, PI3K and AKT. This is the first report of anticancer mechanism involving 2,3-dihydroxy-9,10-anthraquinone in COLO320 cells. The present results might provide helpful suggestions for the design of antitumor drugs toward colorectal cancer treatment. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. CCDC 972510: Experimental Crystal Structure Determination : 8,21-bis(4-t-butylphenyl)-2,15-bis(2,6-diisopropylphenyl)-3a,5a,7,13a,16a,16b,20a,20b,22d,24a,26a,26b-dodecahydrobenzo[1,12]benzo[13',14']isoquinolino[6'',5'',4'':8',9',10']pentapheno[2',3':3,4]tetrapheno[9,8,7-def]isoquinoline-1,3,14,16(2H,15H)-tetrone toluene acetonitrile solvate

    KAUST Repository

    Das, Soumyajit

    2014-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  2. Association of parents' and children's physical activity and sedentary time in Year 4 (8-9) and change between Year 1 (5-6) and Year 4: a longitudinal study.

    Science.gov (United States)

    Jago, Russell; Solomon-Moore, Emma; Macdonald-Wallis, Corrie; Thompson, Janice L; Lawlor, Deborah A; Sebire, Simon J

    2017-08-17

    Parents could be important influences on child physical activity and parents are often encouraged to be more active with their child. This paper examined the association between parent and child physical activity and sedentary time in a UK cohort of children assessed when the children were in Year 1 (5-6 years old) and in Year 4 (8-9 years old). One thousand two hundred twenty three children and parents provided data in Year 4 and of these 685 participated in Year 1. Children and parents wore an accelerometer for five days including a weekend. Mean minutes of sedentary time and moderate-to-vigorous intensity physical activity (MVPA) were derived. Multiple imputation was used to impute all missing data and create complete datasets. Linear regression models examined whether parent MVPA and sedentary time at Year 4 and at Year 1 predicted child MVPA and sedentary time at Year 4. Change in parent MVPA and sedentary time was used to predict change in child MVPA and sedentary time between Year 1 and Year 4. Imputed data showed that at Year 4, female parent sedentary time was associated with child sedentary time (0.13, 95% CI = 0.00 to 0.27 mins/day), with a similar association for male parents (0.15, 95% CI = -0.02 to 0.32 mins/day). Female parent and child MVPA at Year 4 were associated (0.16, 95% CI = 0.08 to 0.23 mins/day) with a smaller association for male parents (0.08, 95% CI = -0.01 to 0.17 mins/day). There was little evidence that either male or female parent MVPA at Year 1 predicted child MVPA at Year 4 with similar associations for sedentary time. There was little evidence that change in parent MVPA or sedentary time predicted change in child MVPA or sedentary time respectively. Parents who were more physically active when their child was 8-9 years old had a child who was more active, but the magnitude of association was generally small. There was little evidence that parental activity from three years earlier predicted child activity at age 8-9, or

  3. Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

    Directory of Open Access Journals (Sweden)

    David Collu

    2009-12-01

    Full Text Available A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against emergent and re-emergent human and cattle infectious diseases (AIDS, hepatitis B and C, tuberculosis, bovine viral diarrhea. In particular, these compounds were evaluated in vitro against representatives of different virus classes, such as a HIV-1 (Retrovirus, a HBV (Hepadnavirus and the single-stranded RNA+ viruses Yellow fever virus (YFV and Bovine viral diarrhea virus (BVDV, both belonging to the Flaviridae. Compounds 2c, 2g and 3d showed a modest activity against CVB-2. The molecular structures of the starting imide 1 and one of propyl-piperazine derivatives, 3b, have been determined by an X-ray crystallography study.

  4. Ocular Hypotensive Response in Nonhuman Primates of (8R)-1-[(2S)-2-Aminopropyl]-8,9-dihydro-7H-pyrano[2,3-g]indazol-8-ol a Selective 5-HT2 Receptor Agonist.

    Science.gov (United States)

    May, Jesse A; Sharif, Najam A; McLaughlin, Marsha A; Chen, Hwang-Hsing; Severns, Bryon S; Kelly, Curtis R; Holt, William F; Young, Richard; Glennon, Richard A; Hellberg, Mark R; Dean, Thomas R

    2015-11-25

    Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular pressure (IOP) in a nonhuman primate model of glaucoma. Although 1-[(2S)-2-aminopropyl]indazol-6-ol (AL-34662) was shown to have good efficacy in this nonhuman primate model of ocular hypertension as well as a desirable physicochemical and permeability profile, subsequently identified cardiovascular side effects in multiple species precluded further clinical evaluation of this compound. Herein, we report selected structural modifications that resulted in the identification of (8R)-1-[(2S)-2-aminopropyl]-8,9-dihydro-7H-pyrano[2,3-g]indazol-8-ol (13), which displayed an acceptable profile to support advancement for further preclinical evaluation as a candidate for proof-of-concept studies in humans.

  5. The analyzing power Asub(y)[(theta) for 12C(n,nsub(0,1))12C betwen 8.9 and] 14.9 MeV neutron energy

    International Nuclear Information System (INIS)

    Woye, E.; Tornow, W.; Mack, G.; Clegg, T.B.; Wylie, W.

    1983-01-01

    The analyzing power Asub(#betta#)(theta) for 12 C(n,n) 12 C elastic scattering and for inelastic scattering to the first excited state (Jsup(π) = 2 + , Q = -4.44 MeV) of 12 C was measured in the energy range from 8.9 to 14.9 MeV in 1 MeV steps. A pulsed polarized neutron beam was produced via the 2 H(d vector,n vector) 3 He polarization transfer reaction. Monte Carlo simulations were used to correct the data for finite geometry and multiple scattering effects. The Asub(#betta#) data, together with publsihed cross-section data, were analyzed in the framework of the spherical optical model and in the coupled-channels formalism. A good description of the data has been achieved. (orig.)

  6. Analyzing power Asub(y)((theta) for /sup 12/C(n,nsub(0,1))/sup 12/C betwen 8. 9 and) 14. 9 MeV neutron energy

    Energy Technology Data Exchange (ETDEWEB)

    Woye, E.; Tornow, W.; Mack, G. (Tuebingen Univ. (Germany, F.R.). Physikalisches Inst.); Floyd, C.E.; Guss, P.P.; Murphy, K.; Byrd, R.C.; Wender, S.A.; Walter, R.L. (Duke Univ., Durham, NC (USA). Dept. of Physics; Triangle Universities Nuclear Lab., Durham, NC (USA))

    1983-02-01

    The analyzing power Asub(..gamma..)(theta) for /sup 12/C(n,n)/sup 12/C elastic scattering and for inelastic scattering to the first excited state (Jsup(..pi..) = 2/sup +/, Q = -4.44 MeV) of /sup 12/C was measured in the energy range from 8.9 to 14.9 MeV in 1 MeV steps. A pulsed polarized neutron beam was produced via the /sup 2/H(d vector,n vector)/sup 3/He polarization transfer reaction. Monte Carlo simulations were used to correct the data for finite geometry and multiple scattering effects. The Asub(..gamma..) data, together with publsihed cross-section data, were analyzed in the framework of the spherical optical model and in the coupled-channels formalism. A good description of the data has been achieved.

  7. Comparison of peak discharges among sites with and without valley fills for the July 8-9, 2001 flood in the headwaters of Clear Fork, Coal River basin, mountaintop coal-mining region, southern West Virginia

    Science.gov (United States)

    Wiley, Jeffrey B.; Brogan, Freddie D.

    2003-01-01

    The effects of mountaintop-removal mining practices on the peak discharges of streams were investigated in six small drainage basins within a 7-square-mile area in southern West Virginia. Two of the small basins had reclaimed valley fills, one basin had reclaimed and unreclaimed valley fills, and three basins did not have valley fills. Indirect measurements of peak discharge for the flood of July 8-9, 2001, were made at six sites on streams draining the small basins. The sites without valley fills had peak discharges with 10- to 25-year recurrence intervals, indicating that rainfall intensities and totals varied among the study basins. The flood-recurrence intervals for the three basins with valley fills were determined as though the peak discharges were those from rural streams without the influence of valley fills, and ranged from less than 2 years to more than 100 years.

  8. Study of magnetic properties and relaxation in amorphous Fe73.9Nb3.1Cu0.9Si13.2B8.9 thin films produced by ion beam sputtering

    International Nuclear Information System (INIS)

    Celegato, F.; Coiesson, M.; Magni, A.; Tiberto, P.; Vinai, F.; Kane, S. N.; Modak, S. S.; Gupta, A.; Sharma, P.

    2007-01-01

    Amorphous Fe 73.9 Nb 3.1 Cu 0.9 Si 13.2 B 8.9 thin films have been produced by ion beam sputtering with two different beam energies (500 and 1000 eV). Magnetic measurements indicate that the samples display a uniaxial magnetic anisotropy, especially for samples prepared with the lower beam energy. Magnetization relaxation has been measured on both films with an alternating gradient force magnetometer and magneto-optical Kerr effect. Magnetization relaxation occurs on time scales of tens of seconds and can be described with a single stretched exponential function. Relaxation intensity turns out to be higher when measured along the easy magnetization axis

  9. The synthesis and characterization of 1,2-dihydroxyimino-3,6-di-aza-8,9-O-iso-butylidene nonane and its complexes with Ni(II), Cu(II), Zn(II) and Cd(II)

    International Nuclear Information System (INIS)

    Canpolat, E.; Kaya, M.; Gorgulu, A.O.

    2002-01-01

    1,2-dihydroxyimino-3,6-di-aza-8,9-O-iso-butylidene nonane (H 2 L) was synthesized starting from 1,2-O-iso-butylidene-4-aza-6-amino hexane (RNH 2 ) and antichloroglyoxime. Ni(II) and Cu(II) complexes of H 2 L have a metal:ligand ratio 1:2 and the ligand coordinates through two N atoms, as do most of the vic-dioximes. However, Zn(II) and Cd(II) complexes of H 2 L have a metal: ligand ratio 1:1 and one chloride ion and one water molecule are also coordinated to the metal ion. Structures of the ligand and its transition-metal complexes are proposed, according to elemental analysis, IR, 13 C and 1 H NMR spectra, magnetic susceptibility measurements and thermogravimetric analyses (TGA). (author)

  10. One electron reduction of 1,2 dihydroxy 9,10 anthraquinone and its transition metal complexes in aqueous-isopropanol-acetone mixed solvent: a steady state-state and pulse radiolysis study

    International Nuclear Information System (INIS)

    Das, Saurabh; Mandal, Parikshit C.; Rath, Madhab C.; Mukherjee, Tulsi

    1998-01-01

    One electron reduction of 1,2 dihydroxy 9,10 anthraquinone and its Cu(II) and Ni(II) and Fe(III) complexes have been studied in aqueous-isopropanol-acetone solvent. Results indicate that the reducing ketyl radical generated reacts with the ligand forming semiquinones which undergoes a disproportionation reaction. Formation and decay rates of semiquinones was calculated using pulse radiolysis. (author)

  11. Polymeric membrane neodymium(III)-selective electrode based on 11,13-diaza-4,7,12-trioxo-2(3),8(9)-dibenzoyl- cyclotetridecane-1,11-diene

    Energy Technology Data Exchange (ETDEWEB)

    Chandra, Sulekh [Department of Chemistry, Zakir Husain College, University of Delhi, J.L.N. Marg, New Delhi, 110002 (India)], E-mail: schandra_00@yahoo.com; Singh, Dev Raj [Department of Chemistry, Zakir Husain College, University of Delhi, J.L.N. Marg, New Delhi, 110002 (India)

    2009-02-25

    We found that 11, 13-diaza-4, 7, 12-trioxo-2(3), 8(9)-dibenzoyl-cyclotetridecane-1, 11-diene (DATODBCT) can be used as an excellent ionophore in the construction of a novel neodymium(III) poly(vinylchloride) (PVC)-based membrane sensor. A membrane composition of 29% poly(vinylchloride), 59% dibutylphthalate (DBP), 9% DATODBCT and 3% sodiumtetrakis (p-chlorophenyl) borate (NaTpClPB), led to the optimum results. The Nd(III)-selectivity of the sensor, is relatively better as compared to a large number of lanthanide metal ions, such as lanthanum, gadolinium, samarium, dysprosium, praseodymium and ytterbium ions. The sensor response is Nernstian (with slope of 19.4 {+-} 0.3 mV per decade for the triply charged ion) over a wide concentration range (1.0 x 10{sup -8} to 1.0 x 10{sup -1} mol L{sup -1}) with a detection limit of 8.0 x 10{sup -7} mol L{sup -1}, a relatively fast response time, in the whole concentration range (<15 s), and a considerable life time at least for seven weeks in the pH range of 3.0-7.0.

  12. Polymeric membrane neodymium(III)-selective electrode based on 11,13-diaza-4,7,12-trioxo-2(3),8(9)-dibenzoyl- cyclotetridecane-1,11-diene

    International Nuclear Information System (INIS)

    Chandra, Sulekh; Singh, Dev Raj

    2009-01-01

    We found that 11, 13-diaza-4, 7, 12-trioxo-2(3), 8(9)-dibenzoyl-cyclotetridecane-1, 11-diene (DATODBCT) can be used as an excellent ionophore in the construction of a novel neodymium(III) poly(vinylchloride) (PVC)-based membrane sensor. A membrane composition of 29% poly(vinylchloride), 59% dibutylphthalate (DBP), 9% DATODBCT and 3% sodiumtetrakis (p-chlorophenyl) borate (NaTpClPB), led to the optimum results. The Nd(III)-selectivity of the sensor, is relatively better as compared to a large number of lanthanide metal ions, such as lanthanum, gadolinium, samarium, dysprosium, praseodymium and ytterbium ions. The sensor response is Nernstian (with slope of 19.4 ± 0.3 mV per decade for the triply charged ion) over a wide concentration range (1.0 x 10 -8 to 1.0 x 10 -1 mol L -1 ) with a detection limit of 8.0 x 10 -7 mol L -1 , a relatively fast response time, in the whole concentration range (<15 s), and a considerable life time at least for seven weeks in the pH range of 3.0-7.0

  13. Calibration setting numbers for dose calibrators for the PET isotopes "5"2Mn, "6"4Cu, "7"6Br, "8"6Y, "8"9Zr, "1"2"4I

    International Nuclear Information System (INIS)

    Wooten, A. Lake; Lewis, Benjamin C.; Szatkowski, Daniel J.; Sultan, Deborah H.; Abdin, Kinda I.; Voller, Thomas F.; Liu, Yongjian; Lapi, Suzanne E.

    2016-01-01

    For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose calibrator. These devices depend on a “calibration setting number”, but many recommended settings from manuals were interpolated based on standard sources of other radionuclide(s). We conducted HPGe gamma-ray spectroscopy, resulting in a reference for determining settings in two types of vessels containing one of several PET radionuclides. Our results reiterate the notion that in-house, experimental calibrations are recommended for different radionuclides and vessels. - Highlights: • Dose calibrators measure radioactivity by ionization of gas from emitted radiation. • Accuracy of dose calibrators depends on “calibration setting numbers” for isotopes. • Many manufacturer settings are interpolated from emissions of other radionuclides. • As a high-precision reference, HPGe gamma-ray spectroscopy was conducted. • New calibrations were found for PET isotopes "5"2Mn, "6"4Cu, "7"6Br, "8"6Y, "8"9Zr, and "1"2"4I.

  14. Off-on fluorescent sensor based on the bis(2,4,7,8,9-pentamethyldipyrrolylmethene-3-yl)methane for detection of Cd{sup 2+} and Hg{sup 2+} cations

    Energy Technology Data Exchange (ETDEWEB)

    Bumagina, Natalia A., E-mail: nad@isc-ras.ru [G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences (ISC RAS), 1 Akademicheskaya St., 153045 Ivanovo (Russian Federation); Antina, Elena V., E-mail: eva@isc-ras.ru [G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences (ISC RAS), 1 Akademicheskaya St., 153045 Ivanovo (Russian Federation); Sozonov, Dmitry I., E-mail: super_dk@mail.ru [Ivanovo State University of Chemistry and Technology (ISUCT), 7 Sheremetevskij Prosp., 153000 Ivanovo (Russian Federation)

    2017-03-15

    The off-on fluorescent chemosensor based on the bis(2,4,7,8,9-pentamethyldipyrrolylmethene-3-yl)methane for detection of Cd{sup 2+} and Hg{sup 2+} ions was obtained and its metal ion sensing properties were investigated. The bis(dipyrrin) exhibited remarkably fluorescence enhancement (150- and 40-fold) to Cd{sup 2+} and Hg{sup 2+} ions, respectively, with significant color change on the background of other metal ions in propanol-1/cyclohexane (1:30) binary mixture. Consequently, it can be used as a “naked eye” indicator with an obvious color change from yellow-orange to orange-green color upon the addition of Cd{sup 2+} and Hg{sup 2+}. The fluorescent response mechanism of bis(dipyrrin) to Cd{sup 2+} and Hg{sup 2+} was based on the fluorescence enhancement effect upon complexation (CHEF) due to formation of a metal–ligand (2:2) complex [M{sub 2}L{sub 2}]. The detection limit of Cd{sup 2+} and Hg{sup 2+} ions was 2 × 10{sup –9} and 1.7 × 10{sup –8} M ions, respectively.

  15. Study of the proton momentum spectrum from deuteron fragmentation at 8.9 GeV/c and an estimate of admixture parameters for the six-quark state in deuteron

    International Nuclear Information System (INIS)

    Ableev, V.G.; Abdushukurov, D.A.; Avramenko, S.A.

    1982-01-01

    Using a magnetic spectrometer with proportional chambers and Cherenkov counters, the momentum spectrum of protons emitted at angles below O.4 deg in the stripping reaction d+ 12 C → p+X has been measured at a deuteron momentum of 8.9 GeV/c for the proton momentum in the range of 3.56 GeV/c <= p <8.05 GeV/c (-206 MeV/c <= p*sub(parallel) <= 580 MeV/c in the deuteron rest system). From the analysis of the invariant cross sections the estimates of parameters of six-quark state admixture in a deuteron are obtained: the admixture-(3.1+-0.2)%, the average square radius of the six-cquark state-(0.87-0.10) Fm, a relative phase of two-nucleon and six-quark components-(61 deg +- 11 deg) for the two-nucleon Reid wave function with a soft core, respectively, =(4.3+-0.4)%, (0.95+-0.05) lm and (82 deg +- 6 deg) for the Paris potential wave function. In the proton momentum region of 296 MeV/c < p*sub(parallel) <= 378 MeV/c a peculiarity in the spectrum has been observed corresponding kinematically to the production of a dibaryon resonance with a mass ranging from 2.0 to 2.2 GeV

  16. Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids.

    Science.gov (United States)

    Jennette, K W; Jeffrey, A M; Blobstein, S H; Beland, F A; Harvey, R G; Weinstein, I B

    1977-03-08

    The covalent binding of benzo[a]pyrene 4,5-oxide and benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide isomer I and isomer II to nucleic acids in aqueous acetone solution has been investigated. Benzo[a]pyrene 4,5-oxide reacted preferentially with guanosine residues. On the other hand, benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide isomer I and II reacted extensively with guanosine, adenosine, and cytidine residues. Time course studies showed that the reactivity of isomer I or isomer II with homopolyribonucleotides followed the order poly(G) greater than poly(A) greater than poly(C). Alkaline or enzymatic hydrolysis of the modified nucleic acids and subsequent chromatography on Sephadex LH-20 columns yielded benzo[a]pyrene-nucleotide adducts. These were enzymatically converted to the corresponding nucleosides which were resolved into several distinct components by high-pressure liquid chromatography. Evidence was obtained for the presence of multiple nucleoside adducts of guanosine, adenosine, cytidine, deoxyguanosine, deoxyadenosine, and deoxycytidine. The HPLC profiles of adducts formed with isomer I were different from the corresponding profiles of adducts formed with isomer II. Structural aspects of these nucleoside adducts are discussed.

  17. Persistence of hepatitis B immune memory until 9-10 years of age following hepatitis B vaccination at birth and DTaP-IPV-HB-PRP∼T vaccination at 2, 4 and 6 months.

    Science.gov (United States)

    Kosalaraksa, Pope; Chokephaibulkit, Kulkanya; Benjaponpitak, Suwat; Pancharoen, Chitsanu; Chuenkitmongkol, Sunate; B'Chir, Siham; Da Costa, Xavier; Vidor, Emmanuel

    2018-01-15

    To evaluate the long-term persistence of anti-hepatitis B surface (HBs) antibodies and the response to a HB challenge re-vaccination in children who had received a primary series of DTaP-IPV-HB-PRP∼T (Hexaxim™) or DTaP-IPV-HB/PRP∼T (Infanrix hexa™). Two cohorts of participants who had previously received HB vaccine at birth followed by either DTaP-IPV-HB-PRP∼T or DTaP-IPV-HB/PRP∼T co-administered with PCV7 at 2, 4, 6 months of age in a randomized, Phase III, observer-blind study in Thailand, were followed up for anti-HBs antibodies (geometric mean concentrations [GMCs] and seroprotection [SP] rate [% of participants with a titer ≥10 mIU/mL]) at 12-18 months of age and 9-10 years of age. A monovalent HB challenge re-vaccination was administered at 9-10 years of age and the anamnestic response was evaluated. Anti-HBs GMCs and SP rates in the DTaP-IPV-HB-PRP∼T and DTaP-IPV-HB/PRP∼T groups were high and similar post-primary vaccination series (2477 mIU/mL and 99.5% and 2442 mIU/mL and 99.5%, respectively) and declined to a similar extent in each group at 12-18 months (154.5 mIU/mL and 90.8% and 162.3 mIU/mL and 96.5%, respectively). Antibody levels further declined at 9-10 years of age (13.3 mIU/mL and 49.3% and 8.0 mIU/mL and 42.9%) and a strong anamnestic response occurred in each group post-HB challenge re-vaccination (92.8% and 98.7%, respectively). The kinetics of long-term anti-HBs antibody persistence were similar following a primary series of DTaP-IPV-HB-PRP∼T or DTaP-IPV-HB/PRP∼T. The response to a subsequent HB challenge re-vaccination was strong and similar in each group, demonstrating persisting immune memory.

  18. The most luminous z ∼ 9-10 galaxy candidates yet found: The luminosity function, cosmic star-formation rate, and the first mass density estimate at 500 Myr

    International Nuclear Information System (INIS)

    Oesch, P. A.; Illingworth, G. D.; Magee, D.; Bouwens, R. J.; Labbé, I.; Smit, R.; Franx, M.; Van Dokkum, P. G.; Momcheva, I.; Ashby, M. L. N.; Fazio, G. G.; Huang, J.-S.; Willner, S. P.; Gonzalez, V.; Trenti, M.; Brammer, G. B.; Skelton, R. E.; Spitler, L. R.

    2014-01-01

    We present the discovery of four surprisingly bright (H 160 ∼ 26-27 mag AB) galaxy candidates at z ∼ 9-10 in the complete HST CANDELS WFC3/IR GOODS-N imaging data, doubling the number of z ∼ 10 galaxy candidates that are known, just ∼500 Myr after the big bang. Two similarly bright sources are also detected in a reanalysis of the GOODS-S data set. Three of the four galaxies in GOODS-N are significantly detected at 4.5σ-6.2σ in the very deep Spitzer/IRAC 4.5 μm data, as is one of the GOODS-S candidates. Furthermore, the brightest of our candidates (at z = 10.2 ± 0.4) is robustly detected also at 3.6 μm (6.9σ), revealing a flat UV spectral energy distribution with a slope β = –2.0 ± 0.2, consistent with demonstrated trends with luminosity at high redshift. Thorough testing and use of grism data excludes known low-redshift contamination at high significance, including single emission-line sources, but as-yet unknown low redshift sources could provide an alternative solution given the surprising luminosity of these candidates. Finding such bright galaxies at z ∼ 9-10 suggests that the luminosity function for luminous galaxies might evolve in a complex way at z > 8. The cosmic star formation rate density still shows, however, an order-of-magnitude increase from z ∼ 10 to z ∼ 8 since the dominant contribution comes from low-luminosity sources. Based on the IRAC detections, we derive galaxy stellar masses at z ∼ 10, finding that these luminous objects are typically 10 9 M ☉ . This allows for a first estimate of the cosmic stellar mass density at z ∼ 10 resulting in log 10  ρ ∗ =4.7 −0.8 +0.5 M ☉ Mpc –3 for galaxies brighter than M UV ∼ –18. The remarkable brightness, and hence luminosity, of these z ∼ 9-10 candidates will enable deep spectroscopy to determine their redshift and nature, and highlights the opportunity for the James Webb Space Telescope to map the buildup of galaxies at redshifts much earlier than z ∼ 10.

  19. Double-differential beryllium neutron cross sections at incident neutron energies of 5. 9, 10. 1, and 14. 2 MeV. [5. 9 to 14. 2 MeV, differential cross sections, ENDF/B-IV

    Energy Technology Data Exchange (ETDEWEB)

    Drake, D.M.; Auchampaugh, G.F.; Arthur, E.D.; Ragan, C.E.; Young, P.G.

    1976-08-01

    Beryllium neutron-production cross sections were measured using the time-of-flight technique at incident neutron energies of 5.9, 10.1, and 14.2 MeV, and at laboratory angles of 25, 27.5, 30, 35, 45, 60, 80, 100, 110, 125, and 145/sup 0/. The differential elastic and inelastic cross sections are presented. Inelastic is defined here as those reactions that proceed through the states at 1.69-, 2.43-, 2.8-, and 3.06-MeV excitation energy in /sup 9/Be. Comparison of emission energy spectra with calculations using the ENDF/B-IV beryllium cross sections shows that the ENDF/B cross sections strongly overemphasize the low lying states in /sup 9/Be.

  20. Iptycene synthesis: A new method for attaching a 2,3-anthracene moiety to the 9,10-positions of another anthracene moiety - Exceptional conditions for a Lewis acid catalyzed Diels-Alder reaction

    Science.gov (United States)

    Chen, Yong-Shing; Hart, Harold

    1989-01-01

    An efficient three-step method for appending a 2,3-anthracene moiety to the 9,10-positions of an existing anthracene moiety is described. The first step uses excess 1,4-anthraquinone (3 equiv) and aluminum chloride (6 equiv) to obtain the anthracene-quinone cycloadduct (omission of the AlCl3 resulted in no adduct). The resulting diketone was reduced to the corresponding diol (excess LiAlH4), which was dehydrated to the arene with phosphorus oxychloride and pyridine. Specific examples include the preparation of heptipycene 8 from pentiptycene 6 (66 percent overall yield) and a similar conversion of 8 to the noniptycene 13 (75 percent overall yield). The methodology led to a markedly improved synthesis of tritriptycene 9 and the first synthesis of undecaiptycene 14.

  1. (4bS,8aS-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-yl acetate

    Directory of Open Access Journals (Sweden)

    Radouane Oubabi

    2014-03-01

    Full Text Available The hemisynthesis of the title compound, C22H32O2, was carried out through direct acetylation reaction of the naturally occurring diterpene totarol [systematic name: (4bS,8aS-4b,8,8-trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-2-ol]. The molecule is built up from three fused six membered rings, one saturated and two unsaturated. The central unsaturated ring has a half-chair conformation, whereas the other unsaturated ring displays a chair conformation. The absolute configuration is deduced from the chemical pathway. The value of the Hooft parameter [−0.10 (6] allowed this absolute configuration to be confirmed.

  2. Influence of Ni(II) and Fe(III) complexes of 1,2 dihydroxy 9,10 anthraquinone on the modification in calf thymus DNA upon gamma irradiation

    International Nuclear Information System (INIS)

    Das, Saurabh; Mandal, Parikshit C.

    2009-01-01

    Ionizing radiation when allowed to fall upon cells or DNA, the radicals produced modify the base-pair region of the double strands. Radiation-induced double-strand modifications in calf thymus DNA were detected using Ni(II) and Fe(III) complexes of 1,2 dihydroxy 9,10 anthraquinone (DHA). 60 Co was used as the source for γ-radiation and ethidium bromide (EB) as the fluorescent dye for detecting double-strand modifications caused in DNA. Results show that the Fe(III)-DHA complex is more efficient in modifying the base-pair region in double-stranded DNA in comparison to DHA or the Ni(II)-DHA complex

  3. Ten-year changes in positive and negative marker food, fruit, vegetables, and salad intake in 9-10 year olds: SportsLinx 2000-2001 to 2010-2011.

    Science.gov (United States)

    Boddy, L M; Abayomi, J; Johnson, B; Hackett, A F; Stratton, G

    2014-06-01

    To investigate changes in intakes of 'negative' and 'positive' foods, fruit, vegetables, and salad in serial cohorts of 9-10-year-old children from 2000-2001 to 2010-2011. For this serial, cross-sectional study, children in school year 5 (9-10 years of age) completed the SportsLinx Lifestyles Survey [n = 30,239 (15,336 boys and 14,903 girls)]. Changes in positive and negative food scores, and the proportion of boys and girls reportedly consuming fruit, vegetables and salad on the previous day to surveying, were investigated annually from 2000 to 2011. The consumption of negative foods declined and positive foods increased significantly compared to baseline. Positive changes in fruit, vegetables and salad consumption were observed over time, with the most recent cohort more likely to consume fruit, vegetables and salad compared to the 2000-2001 baseline. Girls displayed more favourable positive and negative food scores and were more likely to consume fruit, salad and vegetables across several study years compared to boys. The consumption of negative and positive foods, fruit, vegetables, and salad has improved over the last 10 years. In addition, girls appear to have better positive and negative food scores, and were more likely to consume fruit, vegetables and salad, across a number of study years or cohorts compared to boys. These encouraging findings suggest that children's food intake has improved since 2000. Furthermore, the data indicate that boys and girls may require separate or different healthy eating messages to further improve food intake. © 2013 The Authors Journal of Human Nutrition and Dietetics © 2013 The British Dietetic Association Ltd.

  4. Impact of neighbourhood food environment on food consumption in children aged 9-10 years in the UK SPEEDY (Sport, Physical Activity and Eating behaviour: Environmental Determinants in Young people) study.

    Science.gov (United States)

    Skidmore, Paula; Welch, Ailsa; van Sluijs, Esther; Jones, Andrew; Harvey, Ian; Harrison, Flo; Griffin, Simon; Cassidy, Aedín

    2010-07-01

    Poor diet in childhood increases risk of obesity but the relationship between access to food and children's food choice is underexplored. We determined relationships between distance to and density of food outlets on children's food choice. Children (n 1721) aged 9-10 years who participated in a cross-sectional study from a sample of state and private schools across urban and rural areas. Food consumption was reported using a short validated FFQ. A Geographic Information System was used to determine proximity to local food outlets. Multivariable regression analyses were performed to determine associations between food consumption and distance to and density of local food outlets. Norfolk, England. Boys (n 754) and girls (n 967) aged 9-10 years. The impact of distance to or density of food outlets on food choice was small after adjustment. Living further away from a supermarket increased portions of fruit (0.11 portions/week per 1 km increase in distance to nearest supermarket, P < 0.05) and vegetables (0.11 portions/week, P < 0.05) consumed. Living closer to convenience stores was also associated with an increased consumption of crisps, chocolate and white bread. Density of supermarkets was associated with both an increase in vegetable intake (0.31 portions/week, P < 0.05) and unhealthy foods. Distance to and density of food outlets are both associated with children's food choice, although the impact appears to be small and the relationship is complex. However, the effects of individual foods combined could be important, particularly as even small differences in intake can impact on body weight over time.

  5. Spectroscopic, computational and electrochemical studies on the formation of the copper complex of 1-amino-4-hydroxy-9,10-anthraquinone and effect of it on superoxide formation by NADH dehydrogenase.

    Science.gov (United States)

    Roy, Sanjay; Mondal, Palash; Sengupta, Partha Sarathi; Dhak, Debasis; Santra, Ramesh Chandra; Das, Saurabh; Guin, Partha Sarathi

    2015-03-28

    A 1 : 2 copper(II) complex of 1-amino-4-hydroxy-9,10-anthraquinone (QH) having the molecular formula CuQ2 was prepared and characterized by elemental analysis, NMR, FTIR, UV-vis and mass spectroscopy. The powder diffraction of the solid complex, magnetic susceptibility and ESR spectra were also recorded. The presence of the planar anthraquinone moiety in the complex makes it extremely difficult to obtain a single crystal suitable for X-ray diffraction studies. To overcome this problem, density functional theory (DFT) was used to evaluate an optimized structure of CuQ2. In the optimized structure, it was found that there is a tilt of the two planar aromatic anthraquinone rings of the complex with respect to each other in the two planes containing the O-Cu(II)-O plane. The present study is an important addition to the understanding of the structural aspects of metal-anthracyclines because there are only a few reports on the actual structures of metal-anthracyclines. The theoretical vibrational spectrum of the complex was assigned with the help of vibrational energy distribution analysis (VEDA) using potential energy distribution (PED) and compared with experimental results. Being important in producing the biochemical action of this class of molecules, the electrochemical behavior of the complex was studied in aqueous and non-aqueous solvents to find certain electrochemical parameters. In aqueous media, reduction involves a kinetic effect during electron transfer at an electrode surface, which was characterized very carefully using cyclic voltammetry. Electrochemical studies showed a significant modification in the electrochemical properties of 1-amino-4-hydroxy-9,10-anthraquinone (QH) when bound to Cu(II) in the complex compared to those observed for free QH. This suggests that the copper complex might be a good choice as a biologically active molecule, which was reflected in the lack of stimulated superoxide generation by the complex.

  6. N,N′-Diphenyl-9,10-dioxo-9,10-dihydroanthracene-2,7-disulfonamide

    Directory of Open Access Journals (Sweden)

    Wei-Guan Yuan

    2013-07-01

    Full Text Available The title molecule, C26H18N2O6S2, has an overall Z-shaped conformation, in which the benzene rings are inclined to the anthraquinone mean plane by 60.60 (9 and 50.66 (13°. In the crystal, N—H...O and C—H...O hydrogen bonds link the molecules into layers parallel to the bc plane.

  7. Estimativa da composição química corporal de tourinhos Santa Gertrudes a partir da composição química e física das 9-10-11ª costelas

    Directory of Open Access Journals (Sweden)

    Henrique Wignez

    2003-01-01

    Full Text Available Foram obtidas equações de regressão linear simples para estimar a composição química corporal de bovinos Santa Gertrudes, a partir da composição química e física do corte das 9-10-11ª costelas. Quinze tourinhos, entre nove a 15 meses de idade e de 220 a 505 kg de peso, foram mantidos confinados. Os animais foram abatidos após jejum completo de 18 horas, sendo que seis deles foram abatidos após adaptação. A composição química em água, proteína, extrato etéreo e minerais foi determinada no corte das costelas e em amostras obtidas após moagem completa e homogeneização de todos os tecidos corporais, divididos em: sangue, couro, cabeça + patas, vísceras e carcaça. A composição física do corte das costelas foi obtida por separação manual do músculo, gordura e ossos. O peso do corpo vazio foi altamente correlacionado ao peso da carcaça quente (rsuperscript two = 0,99. As porcentagens de água e extrato etéreo das 9-10-11ª costelas mostraram-se altamente correlacionadas com a composição química do corpo vazio, o que não ocorreu para as porcentagens de proteína e minerais. Esses teores foram calculados pela composição do corpo vazio desengordurado. A composição física do corte das costelas foi eficiente para estimar as porcentagens de água, extrato etéreo e minerais do corpo vazio, utilizando-se a porcentagem de gordura separável das costelas, mas não para estimar o teor de proteína. A composição física do corte das costelas demonstrou ser uma técnica eficiente, mas a composição química apresentou maiores coeficientes de determinação e menores erros da estimativa. Como a porcentagem de água no corpo vazio e no corte das costelas (rsuperscript two = 0,95, e as porcentagens de água e de extrato etéreo no corpo vazio foram altamente correlacionadas (rsuperscript two = 0,94, a porcentagem de água no corte das 9-10-11ª costelas poderia ser a única variável para estimativa da composição qu

  8. Influence of family and friend smoking on intentions to smoke and smoking-related attitudes and refusal self-efficacy among 9-10 year old children from deprived neighbourhoods: a cross-sectional study.

    Science.gov (United States)

    McGee, Ciara E; Trigwell, Joanne; Fairclough, Stuart J; Murphy, Rebecca C; Porcellato, Lorna; Ussher, Michael; Foweather, Lawrence

    2015-03-07

    Smoking often starts in early adolescence and addiction can occur rapidly. For effective smoking prevention there is a need to identify at risk groups of preadolescent children and whether gender-specific intervention components are necessary. This study aimed to examine associations between mother, father, sibling and friend smoking and cognitive vulnerability to smoking among preadolescent children living in deprived neighbourhoods. Cross-sectional data was collected from 9-10 year old children (n =1143; 50.7% girls; 85.6% White British) from 43 primary schools in Merseyside, England. Children completed a questionnaire that assessed their smoking-related behaviour, intentions, attitudes, and refusal self-efficacy, as well as parent, sibling and friend smoking. Data for boys and girls were analysed separately using multilevel linear and logistic regression models, adjusting for individual cognitions and school and deprivation level. Compared to girls, boys had lower non-smoking intentions (P = 0.02), refusal self-efficacy (P = 0.04) and were less likely to agree that smoking is 'definitely' bad for health (P non-smoking intentions in girls (P non-smoking intentions in girls (P < 0.01) but a positive association was found in boys (P = 0.02). Boys who had a smoking friend were less likely to 'definitely' believe that the smoke from other people's cigarettes is harmful (OR 0.57, 95% CI: 0.35 to 0.91, P = 0.02). Further, boys with a smoking friend (OR 0.38, 95% CI: 0.21 to 0.69, P < 0.01) or a smoking sibling (OR 0.45, 95% CI: 0.21 to 0.98) were less likely to 'definitely' believe that smoking is bad for health. This study indicates that sibling and friend smoking may represent important influences on 9-10 year old children's cognitive vulnerability toward smoking. Whilst some differential findings by gender were observed, these may not be sufficient to warrant separate prevention interventions. However, further research is needed.

  9. A novel electrochemiluminescent biosensor based on resonance energy transfer between poly(9,9-di-n-octylfluorenyl-2,7-diyl) and 3,4,9,10-perylenetetracar-boxylic acid for insulin detection.

    Science.gov (United States)

    Zhang, Han; Zuo, Fumei; Tan, Xingrong; Xu, Shenghao; Yuan, Ruo; Chen, Shihong

    2018-05-01

    An electrochemiluminescencent (ECL) biosensor was designed for the determination of insulin using a novel ECL resonance energy transfer (ECL-RET) strategy. In this strategy, carboxyl poly(9,9-dioctyfluorenyl-2,7-diyl) dots (PFO dots) were worked as ECL donor and 3,4,9,10-perylenetetracar-boxylic acid (PTCA) exploited as ECL acceptor, and hydrogen peroxide (H 2 O 2 ) employed as the coreactant. The ECL donor and ECL acceptor were separately labeled with primary antibody (Ab 1 ) and secondary antibody (Ab 2 ), forming a sensing interface to the analyte target, insulin. In this expected sandwich-type ECL biosensor, PFO dots acted as sensing platform and PTCA employed as labels to quench the ECL emission of PFO dots. During the determination process, ECL signal of PFO dots was decreased in a gradual way by the increase of insulin concentration, and the quenching mechanism was also investigated. Under the optimal experimental conditions, the constructed biosensor exhibited an excellent performance, including a wide linear range from 1.0 × 10 -5 ng/mL to 1.0 × 10 2 ng/mL, low detection limit of 3.0 × 10 -6 ng/mL, good stability and selectivity for the detection of insulin. This pair of PFO-PTCA, as a new donor-acceptor pair in ECL-RET system, would provide a promising platform for bioanalysis in ECL field. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Serum Level of Antibodies (IgG, IgM Against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in Children Dermatologically Exposed to Coal Tar

    Directory of Open Access Journals (Sweden)

    Pavel Borský

    2017-06-01

    Full Text Available Crude coal tar (CCT contains polycyclic aromatic hydrocarbons (PAHs. Benzo[a]pyrene (BaP is metabolized into a highly reactive metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE that is able to bind to DNA and creates BPDE-DNA adducts. Adducted DNA becomes immunogenic and induces immune response by production of antibodies against BPDE-DNA adducts (Ab-BPDE-DNA. Circulating Ab-BPDE-DNA was proposed as potential biomarker of genotoxic exposure to BaP (PAHs. Goeckerman therapy (GT of psoriasis uses dermal application of CCT ointment (PAHs. In presented study (children with psoriasis treated by GT; n = 19 the therapy significantly increased the level of Ab-BPDE-DNA (EI = 0.29/0.19–0.34 vs. 0.31/0.25–0.40; median/lower–upper quartile; p < 0.01. The results support the idea of Ab-BPDE-DNA level as a possible tentative indicator of exposure, effects and susceptibility of the organism to the exposure of BaP (PAHs.

  11. One-electron reduction of 1,2-dihydroxy-9,10-anthraquinone and some of its transition metal complexes in aqueous solution and in aqueous isopropanol-acetone-mixed solvent: a steady-state and pulse radiolysis study

    International Nuclear Information System (INIS)

    Das, S.; Bhattacharya, A.; Mandal, P.C.; Rath, M.C.; Mukherjee, T.

    2002-01-01

    One-electron reduction of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its complexes with Cu(II), Ni(II) and Fe(III), by acetone ketyl radical, (CH 3 ) 2 C·OH, was carried out in aqueous solution and in aqueous isopropanol acetone mixed solvent using both steady-state gamma radiolysis and pulse radiolysis techniques. The rate constants for the reduction of DHA at different pH values by the ketyl radical are in the order of ∼10 9 dm 3 mol -1 s -1 , whereas those for the metal complexes are comparatively less. These rate constants are, however, in conformity with the one-electron reduction potentials of the ligand in free DHA and in its metal complexes. Decay kinetics of the one-electron reduced semiquinones of the free ligand and its metal complexes suggest disproportionation of the semiquinone in the case of the free ligand and intermolecular electron transfer from the co-ordinated semiquinone radical to the metal centre in the case of the metal complexes

  12. Photochemistry of 1 and 2-(2-methylphenyl)-1,6-heptadiene. [4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

    Energy Technology Data Exchange (ETDEWEB)

    Barrows, R.D.; Hornback, J.M.

    1982-01-01

    In an attempt to synthesize partially saturated phenanthrene derivatives by an intramolecular Diels-Alder reaction between a photochemically produced o-xylylene (diene) and a tethered dienophile, it was found that 1 and 2 underwent a photochemically allowed (2 + 2) cycloaddition. Irradiation of 1 gave 6-(2-methylphenyl)bicyclo(3.2.0)heptane in 86% yield. Upon irradiation of 2, a benzvalene rearrangement of 2 first took place, producing the meta isomer 2-(3-methylphenyl)-1,6-heptadiene, followed by a (2 + 2) photocycloaddition giving 1-(3-methylphenyl)bicyclo(3.2.0)heptane in 15% yield. Direct irradiation of 2-(3-methylphenyl)-1,6-heptadiene gave the same bicyclo derivative as 2 in 34% yield. Examination of the fluorescence spectra of 1 and 2 in comparison with 1-(2-methylphenyl)propene and 2-(2-methylphenyl)-1-butene, respectively, has shown that 1 may be biased toward (2 + 2) cycloaddition where 2 is not biased toward (2 + 2) photocycloization. Attempts to produce 4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene by an intramolecular Diels-Alder reaction of the o-xylylene produced by irradiation of 3 will also be described.

  13. Effects of DK-002, a synthesized (6aS,cis)-9,10-Dimethoxy-7,11b-dihydro-indeno[2,1-c]chromene-3,6a-diol, on platelet activity.

    Science.gov (United States)

    Lee, Ki-Seon; Khil, Lee-Yong; Chae, Sang-Ho; Kim, Deukjoon; Lee, Byung-Hoon; Hwang, Gwi-Seo; Moon, Chang-Hyun; Chang, Tong-Shin; Moon, Chang-Kiu

    2006-02-02

    In the present study, the mechanism of antiplatelet activity of DK-002, a synthesized (6aS,cis)-9,10-Dimethoxy-7,11b-dihydro-indeno[2,1-c]chromene-3,6a-diol, was investigated. DK-002 inhibited the thrombin, collagen, and ADP-induced rat platelet aggregation in a concentration-dependent manner, with IC50 values of 120, 27, and 47 microM, respectively. DK-002 also inhibited thrombin-induced dense granule secretion, thromboxane A2 synthesis, and [Ca2+]i elevation in platelets. DK-002 did not show any significant effect on ADP-induced inhibition of cyclic AMP elevation by prostaglandin E1, but DK-002 was confirmed to inhibit ADP-induced [Ca2+]i elevation and shape change. DK-002 inhibited 4-bromo-A23187-induced [Ca2+]i elevation in the presence of creatine phosphate/creatine phosphokinase (CP/CPK, a ADP scavenging system) and indomethacin (a specific inhibitor of cyclooxygenase). DK-002 also inhibited Ca2+ mobilization in thrombin- or 4-bromo-A23187-stimulated platelets through its inhibitory effects on both Ca2+ release from intracellular stores and Ca2+ influx, in the presence of CP/CPK and indomethacin. Taken together, the present study shows that DK-002 has inhibitory effects on stimulation of platelets, and suggests that its antiplatelet activity might be related to the inhibitory mechanism on Ca2+ mobilization in stimulated platelets.

  14. Ethnic and gender differences in physical activity levels among 9-10-year-old children of white European, South Asian and African-Caribbean origin: the Child Heart Health Study in England (CHASE Study).

    Science.gov (United States)

    Owen, Christopher G; Nightingale, Claire M; Rudnicka, Alicja R; Cook, Derek G; Ekelund, Ulf; Whincup, Peter H

    2009-08-01

    Ethnic differences in physical activity in children in the UK have not been accurately assessed. We made objective measurements of physical activity in 9-10-year-old British children of South Asian, black African-Caribbean and white European origin. Cross-sectional study of urban primary school children (2006-07). Actigraph-GT1M activity monitors were worn by 2071 children during waking hours on at least 1 full day. Ethnic differences in mean daily activity [counts, counts per minute of registered time (CPM) and steps] were adjusted for age, gender, day of week and month. Multilevel modelling allowed for repeated days within individual and clustering within school. In white Europeans, mean daily counts, CPM and mean daily steps were 394,785, 498 and 10,220, respectively. South Asian and black Caribbean children recorded more registered time per day than white Europeans (34 and 36 min, respectively). Compared with white Europeans, South Asians recorded 18 789 fewer counts [95% confidence interval (CI) 6390-31 187], 41 fewer CPM 95% CI 26-57) and 905 fewer steps (95% CI 624-1187). Black African-Caribbeans recorded 25 359 more counts (95% CI 14 273-36 445), and similar CPM, but fewer steps than white Europeans. Girls recorded less activity than boys in all ethnic groups, with 74 782 fewer counts (95% CI 66 665-82 899), 84 fewer CPM (95% CI 74-95) and 1484 fewer steps (95% CI 1301-1668). British South Asian children have lower objectively measured physical activity levels than European whites and black African-Caribbeans.

  15. Tribunale di Bologna, ordinanza del 15 ottobre 2012Art. 18 comma 4 nuovo testo st. lav. su insussistenza del fatto

    Directory of Open Access Journals (Sweden)

    temilavoro.it - redazione

    2012-01-01

    Full Text Available La insussistenza del fatto contestato deve interpretarsi come fatto giuridico, inteso come il fatto globalmente accertato, nell'unicum delle sue componenti oggettiva e soggettiva, dove­dosi correlativamente escludere che essa sia riferibile al solo fatto materiale, posto che tale interpretazione sarebbe palese­mente in violazione dei principi generali di diligenza e buona fede nell'esecuzione del contratto.* La disciplina applicabile al licenziamento disciplinare illegitti­mo consegue alla gravità del fatto, infatti, la recente riforma dell'art. 18 St. Lav. prevede che il giudice ordini la reintegra­zione nelle ipotesi di licenziamento illegittimo anche allorché il fatto rientri tra le condotte punibili con una sanzione conser­vativa, secondo le previsioni dei contratti collettivi e dei codici disciplinari applicabili.* * massime a cura della redazione

  16. Stand Out in Class: restructuring the classroom environment to reduce sedentary behaviour in 9-10-year-olds - study protocol for a pilot cluster randomised controlled trial.

    Science.gov (United States)

    Clemes, Stacy A; Bingham, Daniel D; Pearson, Natalie; Chen, Yu-Ling; Edwardson, Charlotte; McEachan, Rosemary; Tolfrey, Keith; Cale, Lorraine; Richardson, Gerry; Fray, Mike; Bandelow, Stephan; Jaicim, Nishal Bhupendra; Salmon, Jo; Dunstan, David; Barber, Sally E

    2018-01-01

    Sedentary behaviour (sitting) is a highly prevalent negative health behaviour, with individuals of all ages exposed to environments that promote prolonged sitting. Excessive sedentary behaviour adversely affects health in children and adults. As sedentary behaviour tracks from childhood into adulthood, the reduction of sedentary time in young people is key for the prevention of chronic diseases that result from excessive sitting in later life. The sedentary school classroom represents an ideal setting for environmental change, through the provision of sit-stand desks. Whilst the use of sit-stand desks in classrooms demonstrates positive effects in some key outcomes, evidence is currently limited by small samples and/or short intervention durations, with few studies adopting randomised controlled trial (RCT) designs. This paper describes the protocol of a pilot cluster RCT of a sit-stand desk intervention in primary school classrooms. A two-arm pilot cluster RCT will be conducted in eight primary schools (four intervention, four control) with at least 120 year 5 children (aged 9-10 years). Sit-stand desks will replace six standard desks in the intervention classrooms. Teachers will be encouraged to ensure all pupils are exposed to the sit-stand desks for at least 1 h/day on average using a rotation system. Schools assigned to the control arm will continue with their usual practice, no environmental changes will be made to their classrooms. Measurements will be taken at baseline, before randomisation, and at the end of the schools' academic year. In this study, the primary outcomes of interest will be school and participant recruitment and attrition, acceptability of the intervention, and acceptability and compliance to the proposed outcome measures (including activPAL-measured school-time and school-day sitting, accelerometer-measured physical activity, adiposity, blood pressure, cognitive function, academic progress, engagement, and behaviour) for inclusion in a

  17. Immunogenicity of quadrivalent HPV and combined hepatitis A and B vaccine when co-administered or administered one month apart to 9-10 year-old girls according to 0-6 month schedule.

    Science.gov (United States)

    Gilca, Vladimir; Sauvageau, Chantal; Boulianne, Nicole; De Serres, Gaston; Couillard, Michel; Krajden, Mel; Ouakki, Manale; Murphy, Donald; Trevisan, Andrea; Dionne, Marc

    2014-01-01

    No immunogenicity data has been reported after a single dose of the quadrivalent HPV vaccine (qHPV-Gardasil®) and no data are available on co-administration of this vaccine with the HAV/HBV vaccine (Twinrix-Junior®). Two pre-licensure studies reported similar anti-HPV but lower anti-HBs titers when co-administering HPV and HBV vaccines. To assess the immunogenicity of the qHPV and HAV/HBV vaccine when co-administered (Group-Co-adm) or given one month apart (Group-Sep) and to measure the persistence of HPV antibodies three years post-second dose of qHPV vaccine in both study groups. 416 9-10 year-old girls were enrolled. Vaccination schedule was 0-6 months. Anti-HAV and anti-HBs were measured in all subjects 6 months post-first dose and 1 month post-second dose. Anti-HPV were measured 6 months post-first dose in Group-Co-adm and in all subjects 1 and 36 months post-second dose. Six months post-first dose: 100% of subjects had detectable anti-HAV and 56% and 73% had detectable anti-HBs in Group-Co-Adm and Group-Sep, respectively. In Group-Co-adm 94, 100, 99 and 96% had detectable antibodies to HPV 6, 11, 16 and 18, respectively. One month post-second dose of qHPV and HAV/HBV vaccine, in both study groups 99.5-100% of subjects had an anti-HAV titer ≥ 20IU/L, 97.5-97.6% an anti-HBs level ≥ 10IU/L, and 100% had an anti-HPV titer ≥ 3LU. Thirty-six months post-second dose of qHPV all but four subjects (99%) had antibodies to HPV18 and 100% had antibodies to HPV6, 11 and 16. The great majority (97-100%) had an anti-HPV titer ≥ 3 LU. Post-second dose administration of qHPV and HAV/HBV, no meaningful difference was observed in the immune response in the two study groups to any component of vaccines. The results indicate that qHPV and HAV/HBV can be given during the same vaccination session. Two doses of of qHPV and HAV/HBV vaccines induce a strong immune response. Three years post-second dose of qHPV, the great majority of subjects had antibodies to HPV types

  18. Effect of a sport-for-health intervention (SmokeFree Sports on smoking-related intentions and cognitions among 9-10 year old primary school children: a controlled trial

    Directory of Open Access Journals (Sweden)

    Ciara E. McGee

    2016-05-01

    Full Text Available Abstract Background Preventing children from smoking is a public health priority. This study evaluated the effects of a sport-for-health smoking prevention programme (SmokeFree Sports on smoking-related intentions and cognitions among primary school children from deprived communities. Methods A non-randomised-controlled trial targeted 9-10 year old children from Merseyside, North-West England. 32 primary schools received a programme of sport-for-health activities over 7 months; 11 comparison schools followed usual routines. Data were collected pre-intervention (T0, and at 8 months (T1 and one year post-intervention (T2. Smoking-related intentions and cognitions were assessed using an online questionnaire. Intervention effects were analysed using multi-level modelling (school, student, adjusted for baseline values and potential confounders. Mixed-sex focus groups (n = 18 were conducted at T1. Results 961 children completed all assessments and were included in the final analyses. There were no significant differences between the two study groups for non-smoking intentions (T1: β = 0.02, 95 % CI = -0.08–0.12; T2: β = 0.08, 95 % CI = -0.02–0.17 or for cigarette refusal self-efficacy (T1: β = 0.28, 95 % CI = -0.11–0.67; T2: β = 0.23, 95 % CI = -0.07–0.52. At T1 there was a positive intervention effect for cigarette refusal self-efficacy in girls (β = 0.72, 95 % CI = 0.21–1.23. Intervention participants were more likely to ‘definitely’ believe that: ‘it is not safe to smoke for a year or two as long as you quit after that’ (RR = 1.19, 95 % CI = 1.07–1.33, ‘it is difficult to quit smoking once started’ (RR = 1.56, 95 % CI = 1.38–1.76, ‘smoke from other peoples’ cigarettes is harmful’ (RR = 1.19, 95 % CI = 1.20–2.08, ‘smoking affects sports performance’ (RR = 1.73, 95 % CI = 1.59–1.88 and ‘smoking makes ‘no difference

  19. Effect of a sport-for-health intervention (SmokeFree Sports) on smoking-related intentions and cognitions among 9-10 year old primary school children: a controlled trial.

    Science.gov (United States)

    McGee, Ciara E; Trigwell, Joanne; Fairclough, Stuart J; Murphy, Rebecca C; Porcellato, Lorna; Ussher, Michael; Foweather, Lawrence

    2016-05-26

    Preventing children from smoking is a public health priority. This study evaluated the effects of a sport-for-health smoking prevention programme (SmokeFree Sports) on smoking-related intentions and cognitions among primary school children from deprived communities. A non-randomised-controlled trial targeted 9-10 year old children from Merseyside, North-West England. 32 primary schools received a programme of sport-for-health activities over 7 months; 11 comparison schools followed usual routines. Data were collected pre-intervention (T0), and at 8 months (T1) and one year post-intervention (T2). Smoking-related intentions and cognitions were assessed using an online questionnaire. Intervention effects were analysed using multi-level modelling (school, student), adjusted for baseline values and potential confounders. Mixed-sex focus groups (n = 18) were conducted at T1. 961 children completed all assessments and were included in the final analyses. There were no significant differences between the two study groups for non-smoking intentions (T1: β = 0.02, 95 % CI = -0.08-0.12; T2: β = 0.08, 95 % CI = -0.02-0.17) or for cigarette refusal self-efficacy (T1: β = 0.28, 95 % CI = -0.11-0.67; T2: β = 0.23, 95 % CI = -0.07-0.52). At T1 there was a positive intervention effect for cigarette refusal self-efficacy in girls (β = 0.72, 95 % CI = 0.21-1.23). Intervention participants were more likely to 'definitely' believe that: 'it is not safe to smoke for a year or two as long as you quit after that' (RR = 1.19, 95 % CI = 1.07-1.33), 'it is difficult to quit smoking once started' (RR = 1.56, 95 % CI = 1.38-1.76), 'smoke from other peoples' cigarettes is harmful' (RR = 1.19, 95 % CI = 1.20-2.08), 'smoking affects sports performance' (RR = 1.73, 95 % CI = 1.59-1.88) and 'smoking makes 'no difference' to weight' (RR = 2.13, 95 % CI = 1.86-2.44). At T2, significant between

  20. Space, time and group identity in Jubilees 8-9

    African Journals Online (AJOL)

    p1243322

    This paper investigates this change in communication strategy and ... his orientation towards and organisation of space, as revealed in his ideas ..... two versions of the same tradition or the parallel development of an older, .... In the case of Numbers Israel ... with its chronological system of jubilees and heavenly space.

  1. Springer Publishing book booth | 8-9 October

    CERN Multimedia

    CERN Library

    2015-01-01

    Continuing the spirit of the CERN Book Fairs of the past years, Springer Publishing will have a book booth in the foyer of the Main Building, from 8 to 9 October. Some of the latest titles in particle physics and related fields will be on sale.   For the occasion, Professor Ugo Amaldi will present his new book “Particle Accelerators: From Big Bang Physics to Hadron Therapy” on Thursday, 8 October at 5 p.m. in Room F (Charpak room). The presentation will take place in the framework of the Italian Teachers week and will be followed by a signing session. A special highlight at the Springer booth will be the presentation of the CERN-sponsored Open Access book: “J Rafelski (ed): Melting Hadrons, Boiling Quarks - From Hagedorn Temperature to Ultra-Relativistic Heavy-Ion Collisions at CERN; With a Tribute to Rolf Hagedorn”.

  2. Water and environment news. No. 8/9

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-01

    This issue of the News focuses on isotope studies related to lakes. Physical and bio-geochemical processes occurring at and below the surface of lake water influence lake-atmosphere interactions, surface and groundwater hydrology, and climatic archives in lake sediments. The IAEA activities related to lake hydrology studies are highlighted.

  3. Water and environment news. No. 8/9

    International Nuclear Information System (INIS)

    1999-12-01

    This issue of the News focuses on isotope studies related to lakes. Physical and bio-geochemical processes occurring at and below the surface of lake water influence lake-atmosphere interactions, surface and groundwater hydrology, and climatic archives in lake sediments. The IAEA activities related to lake hydrology studies are highlighted

  4. Academic Training Lecture | Game Theory | 8 - 9 May

    CERN Multimedia

    2014-01-01

    Game Theory (1 & 2), by Elias Koutsoupias (Professor of Computer Science, University of Oxford, UK).   Thursday 8 May and Friday 9 May from 11 a.m. to 12 a.m. CERN (500-1-001 - Main Auditorium) Description: This lecture series will present the main directions of Algorithmic Game Theory, a new field that has emerged in the last two decades at the interface of Game Theory and Computer Science, because of the unprecedented growth in size, complexity, and impact of the Internet and the Web. These include the price of anarchy (what is the impact of selfishness on a system of competing entities), computational complexity (can the market find a reasonable solution), mechanisms and auctions (what incentives to give to selfish individuals). See the Indico page here.

  5. Lost circulation technology workshop, October 9-10, 1984

    Energy Technology Data Exchange (ETDEWEB)

    Caskey, B.C. (ed.)

    1985-03-01

    This report summarizes the presentations and discussions of a workshop on lost circulation technology. The workshop identified and defined lost circulation problem areas in field operations, materials, mud effects, and standards. Problem solution needs were also categorized as requiring analytical evaluation and procedure, instrument, and material development.

  6. 44 CFR 9.10 - Identify impacts of proposed actions.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Identify impacts of proposed... impacts of proposed actions. (a) Purpose. The purpose of this section is to ensure that the effects of... adverse impacts associated with the occupancy and modification of floodplains and wetlands and the...

  7. 36 CFR 9.10 - Plan of operations approval.

    Science.gov (United States)

    2010-07-01

    ... injure the ecological or cultural resources of the unit. No new surface mining will be permitted under..., or loss of wildlife habitat, not required for development of the claim; or (5) Where the operations... of cultural resources within the area to be affected by mining operations. Whenever National Register...

  8. The unbound isotopes {sup 9,10}He

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, H.T. [Fundamental Fysik, Chalmers Tekniska Hoegskola, S-412 96 Goeteborg (Sweden); Aksyutina, Yu. [Fundamental Fysik, Chalmers Tekniska Hoegskola, S-412 96 Goeteborg (Sweden); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Aumann, T.; Boretzky, K. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Borge, M.J.G. [Instituto Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Chatillon, A. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Chulkov, L.V. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Kurchatov Institute, RU-123182 Moscow (Russian Federation); Cortina-Gil, D. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); University of Santiago de Compostela, 15706 Santiago de Compostela (Spain); Datta Pramanik, U. [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Emling, H. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Forssen, C. [Fundamental Fysik, Chalmers Tekniska Hoegskola, S-412 96 Goeteborg (Sweden); Fynbo, H.O.U. [Department of Physics and Astronomy, University of Aarhus, DK-8000 Aarhus C (Denmark); Geissel, H.; Ickert, G. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Jonson, B., E-mail: Bjorn.Jonson@chalmers.s [Fundamental Fysik, Chalmers Tekniska Hoegskola, S-412 96 Goeteborg (Sweden); Physics Department, CERN, CH-1211 Geneve 23 (Switzerland); Kulessa, R. [Instytut Fizyki, Universytet Jagiellonski, PL-30-059 Krakow (Poland); Langer, C. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Lantz, M. [Fundamental Fysik, Chalmers Tekniska Hoegskola, S-412 96 Goeteborg (Sweden); LeBleis, T.; Mahata, K. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany)

    2010-10-15

    The unbound nuclei {sup 9}He and {sup 10}He have been produced in proton-knockout reactions from a 280 MeV/u {sup 11}Li beam impinging on a liquid hydrogen target at the ALADIN-LAND setup at GSI. Information on their nuclear structure has been obtained from the relative-energy spectra, {sup 8}He+n and {sup 8}He+2n, employing reaction models incorporating the structure of {sup 11}Li. The {sup 8}He+n relative-energy spectrum is dominated by a strong peak-like structure at low energy, which may be interpreted within the effective-range approximation as the result of an s-wave interaction with a neutron scattering length of -3.17(66) fm. This spectrum also shows evidence for resonance states at 1.33(8) MeV and at 2.4 MeV above the {sup 8}He+n threshold. It is argued that the s-state might not be the {sup 9}He ground state. For {sup 8}He+n+n, the analysis of the relative-energy spectrum gives two alternative possibilities for an interpretation: either a narrow resonance at 1.42(10) MeV ({Gamma}=1.11(76) MeV) superimposed on a correlated background, or two overlapping resonances, a ground state at 1.54(11) MeV ({Gamma}=1.91(41) MeV) together with an excited state at 3.99(26) MeV ({Gamma}=1.64(89) MeV). The two possible interpretations are discussed.

  9. Pulse radiolysis of 9,10-anthraquinone in methanol

    International Nuclear Information System (INIS)

    Mayer, J.; Krasiukianis, R.

    1990-01-01

    The reactions of anthraquinone with intermediates in methanol (e 2 - , . CH 2 O - , . CH 2 OH) were investigated using γ-radiolysis and pulse radiolysis method. The anthraquinone radical anions are reactive towards O 2 (ca 3 x 10 8 mol -1 dm 3 s -1 ) and can disproportionate giving corresponding dianion. (author)

  10. 4-(3-Bromopropyloxy-1-hydroxy-9,10-anthraquinone

    Directory of Open Access Journals (Sweden)

    Natsumi Ohira

    2016-05-01

    Full Text Available In the molecule of the title compound, C17H13BrO4, the anthraquinone ring system is slightly bent, with a dihedral angle of 169.99 (7° between the planes of the two benzene rings. The side chain (O—C—C—C—Br has a gauche–gauche conformation, as indicated by the O—C—C—C and C—C—C—Br torsion angles of −66.9 (2 and −65.8 (2°, respectively. In addition, there is an intramolecular O—H...O hydrogen bond enclosing an S(6 ring motif. The hydrogen-bond donor is bifurcated; in the crystal, a pair of O—H...O hydrogen bonds connects two molecules, forming an inversion dimer with an R22(12 ring motif.

  11. Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones.

    Science.gov (United States)

    Kumar Biswas, Bishyajit; Malpani, Yashwardhan R; Ha, Neul; Kwon, Do-Hyun; Soo Shin, Jin; Kim, Hae-Soo; Kim, Chonsaeng; Bong Han, Soo; Lee, Chong-Kyo; Jung, Young-Sik

    2017-08-01

    Members of a series of 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones (1, Fig. 2) were prepared and tested against representative enteroviruses including Human Coxsackievirus B1 (Cox B1), Human Coxsackievirus B3 (Cox B3), human Poliovirus 3 (PV3), human Rhinovirus 14 (HRV14), human Rhinovirus 21 (HRV 21) and human Rhinovirus 71 (HRV 71). The C-8-tert-butyl group on the tetrahydrobenzene ring in these substances was found to be crucial for their enterovirus activity. One member of this group, 1e, showed single digit micromolar activities (1.6-8.85μM) against a spectrum of viruses screened, and the highest selectivity index (SI) values for Cox B1 (>11.2), for Cox B3 (>11.5), and for PV3 (>51.2), respectively. In contrast, 1p, was the most active analog against the selected HRVs (1.8-2.6μM), and showed the highest selectivity indices among the group of compounds tested. The SI values for 1p were 11.5 for HRV14, 8.4 for HRV21, and 12.1 for HRV71, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. 1-Amino-4-hydroxy-9,10-anthraquinone - An analogue of anthracycline anticancer drugs, interacts with DNA and induces apoptosis in human MDA-MB-231 breast adinocarcinoma cells: Evaluation of structure-activity relationship using computational, spectroscopic and biochemical studies.

    Science.gov (United States)

    Mondal, Palash; Roy, Sanjay; Loganathan, Gayathri; Mandal, Bitapi; Dharumadurai, Dhanasekaran; Akbarsha, Mohammad A; Sengupta, Partha Sarathi; Chattopadhyay, Shouvik; Guin, Partha Sarathi

    2015-12-01

    The X-ray diffraction and spectroscopic properties of 1-amino-4-hydroxy-9,10-anthraquinone (1-AHAQ), a simple analogue of anthracycline chemotherapeutic drugs were studied by adopting experimental and computational methods. The optimized geometrical parameters obtained from computational methods were compared with the results of X-ray diffraction analysis and the two were found to be in reasonably good agreement. X-ray diffraction study, Density Functional Theory (DFT) and natural bond orbital (NBO) analysis indicated two types of hydrogen bonds in the molecule. The IR spectra of 1-AHAQ were studied by Vibrational Energy Distribution Analysis (VEDA) using potential energy distribution (PED) analysis. The electronic spectra were studied by TDDFT computation and compared with the experimental results. Experimental and theoretical results corroborated each other to a fair extent. To understand the biological efficacy of 1-AHAQ, it was allowed to interact with calf thymus DNA and human breast adino-carcinoma cell MDA-MB-231. It was found that the molecule induces apoptosis in this adinocarcinoma cell, with little, if any, cytotoxic effect in HBL-100 normal breast epithelial cell.

  13. Estudio sobre tumores melanóticos del jámster sirio. II. Efecto de la edad del jámster dorado (Mesocricetus auratus sobre la inducción de tumores melanóticos por el 9,10 dimetilbenzantraceno

    Directory of Open Access Journals (Sweden)

    José Perea Sasiaín

    1966-10-01

    Full Text Available En medicina humana es bien conocida la influencia de la edad sobre la frecuencia del melanoma maligno: este tumor es muy infrecuente, si no excepcional, antes de la pubertad. Los pocos casos documentados de transmisión transplacentaria de tumores, han sido en su mayoría melanomas, lo cual prueba que el infante es susceptible al crecimiento de trasplantes de este tumor, proveniente de la madre. En el jamster dorado se han inducido tumores melanóticos mediante una sola aplicación de 9,10 dimetilbenzantraceno (D MBA. Estos tumores no son considerados malignos por su aspecto histológico, no dar metástasis, ni producir la muerte del animal, ni ser transplantables   regularmente a huéspedes homólogos. Son, sin embargo, de grande importancia para el estudio de la inducción de la melanogénesis. El presente estudio fue realizado "con el fin de establecer la influencia que la edad pudiera tener sobre la cantidad de tumores inducidos por el DMBA. Se consideró en particular que el jámster dorado no alcanza su madurez sexual hasta después del mes (45-60 días, descontando casos excepcionales como el observado a los 28 días.

  14. Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.

    Science.gov (United States)

    Vianello, P; Albinati, A; Pinna, G A; Lavecchia, A; Marinelli, L; Borea, P A; Gessi, S; Fadda, P; Tronci, S; Cignarella, G

    2000-06-01

    Various lines of evidence, including molecular modeling studies, imply that the endoethylenic bridge of 3,8-diazabicyclo[3.2. 1]octanes (DBO, 1) plays an essential role in modulating affinity toward mu opioid receptors. This hypothesis, together with the remarkable analgesic properties observed for N(3) propionyl, N(8) arylpropenyl derivatives (2) and of the reverted isomers (3), has prompted us to insert an additional endoethylenic bridge on the piperazine moiety in order to identify derivatives with increased potency toward this receptor class. In the present report, we describe the synthesis of the novel compounds 9,10-diazatricyclo[4.2. 1.1(2,5)]decane (4) and 2,7-diazatricyclo[4.4.0.0(3,8)]decane (5), as well as the representative derivatives functionalized at the two nitrogen atoms by propionyl and arylpropenyl groups (6a-e, 7a-d). Opioid receptor binding assays revealed that, among the compounds tested, the N-propionyl-N-cinnamyl derivatives 6a and 7a exhibited the highest mu-receptor affinity, and remarkably, compound 7a displayed in vivo (mice) an analgesic potency 6-fold that of morphine.

  15. Easy as 1, 2, 3, (4, 5, 6, 7, 8, 9...).

    Science.gov (United States)

    Sheratsky, Rodney E.

    1967-01-01

    A course in movie making should begin with a detailed explanation and demonstration of the camera, with emphasis on caring for the equipment. Students should start by shooting stationary objects: practicing close-up, medium, and long shots of varying length. It is particularly important to get students' films processed quickly so that a critique…

  16. Oslo Epigenetics Symposium 2012. Oslo, Norway, 8-9 November 2012.

    Science.gov (United States)

    Collas, Philippe; Eskeland, Ragnhild

    2013-02-01

    The Oslo Epigenetics Symposium 2012 held in Oslo, Norway, brought together ten speakers from several European countries and the USA for an evening public lecture and a full day of presentations on emerging topics in the field of epigenetics, gene regulation and organization of the cell nucleus.

  17. Pro Internet Explorer 8 & 9 Development Developing Powerful Applications for the Next Generation of IE

    CERN Document Server

    Crowley, Matthew

    2010-01-01

    This book is an in-depth guide to writing applications that embrace and extend the new features and capabilities of Windows Internet Explorer 8 and 9. With solid instruction, hands-on examples, and expert insight direct from the source into extending the browser, you'll learn how to create and maintain powerful applications for Microsoft's next-generation Internet platform. Join author Matthew Crowley as you discover how to take advantage of new features like accelerators, WebSlices, and search providers, and create intense web experiences for the browser that ships by default with the popular

  18. Fusion Energy Division Annual Information Meeting. Agenda and abstracts, April 8-9, 1986

    International Nuclear Information System (INIS)

    1986-01-01

    Abstracts of the presentations are included. The general topics covered included the following: (1) development and technology, and (2) plasma confinement, theory, and FEDC. In addition, abstracts are also given for various invited talks

  19. Annual Disruptive Technologies Conference (8th) Held in Washington, DC on November 8-9, 2011

    Science.gov (United States)

    2011-11-09

    I also appreciate speaking early in the lineup of presentations since it minimizes the chance that I will contradict something you have already...Architectures Enterprise Working Meeting (S&T, CAPE, Policy, COCOM) OV-1 Architecture Definition Industry Day Enabling Technology Identification ...year turnaround time  Video: www.youtube.com/usnavyresearch  Requests submitted online www.onr.navy.mil/techsolutions • Ship Identification

  20. Developmental Dyscalculia and Basic Numerical Capacities: A Study of 8--9-Year-Old Students

    Science.gov (United States)

    Landerl, Karin; Bevan, Anna; Butterworth, Brian

    2004-01-01

    Thirty-one 8- and 9-year-old children selected for dyscalculia, reading difficulties or both, were compared to controls on a range of basic number processing tasks. Children with dyscalculia only had impaired performance on the tasks despite high-average performance on tests of IQ, vocabulary and working memory tasks. Children with reading…

  1. re-sonanceij-ui-y--20-0-2-------------~----------------------------8-9

    Indian Academy of Sciences (India)

    equation'. Such equations (or more generally, the equa- tion 1 + Nx2 = y2 where N is a given positive inte- ger) were studied long back by the Indian mathemati- cians Aryabhatta and Bhaskaracharya, Later they were studied by Fermat, and still later by Euler and La- grange, and somewhere along the way the equation got.

  2. Clustering and Correlates of Multiple Health Behaviours in 9-10 Year Old Children

    NARCIS (Netherlands)

    Elsenburg, Leonie K.; Corpeleijn, Eva; van Sluijs, Esther M. F.; Atkin, Andrew J.

    2014-01-01

    Background: Sleep, physical activity, screen time and dietary behaviours influence health during childhood, but few studies have looked at all of these behaviours simultaneously and previous research has relied predominantly on self- or proxy-reports of physical activity and food frequency

  3. Clustering and correlates of multiple health behaviours in 9-10 year old children.

    Directory of Open Access Journals (Sweden)

    Leonie K Elsenburg

    Full Text Available Sleep, physical activity, screen time and dietary behaviours influence health during childhood, but few studies have looked at all of these behaviours simultaneously and previous research has relied predominantly on self- or proxy-reports of physical activity and food frequency questionnaires for the assessment of diet.To assess the prevalence and clustering of health behaviours and examine the socio-demographic characteristics of children that fail to meet multiple health behaviour guidelines.Data are from the Sport, Physical activity and Eating behaviour: Environmental Determinants in Young people (SPEEDY study. Participants (n = 1472, 42.9% male were dichotomized based on whether or not they met public health guidelines for accelerometer-assessed physical activity, diet-diary assessed fruit/vegetable intake and fat/non-milk extrinsic sugar (NMES intake, and self-reported screen time and sleep duration. Behavioural clustering was assessed using an observed over expected ratio (O/E. Socio-demographic characteristics of participants that failed to meet multiple health behaviour guidelines were examined using ordinal logistic regression. Data were analysed in 2013.83.3% of children failed to meet guidelines for two or more health behaviours. The O/E ratio for two behavioural combinations significantly exceeded 1, both of which featured high screen time, insufficient fruit/vegetable consumption and excessive fat/NMES intake. Children who were older (Proportional odds ratio (95% confidence interval: 1.69 (1.21,2.37 and those that attended a school with a physical activity or diet-related policy (1.28 (1.01,1.62 were more likely to have a poor health behaviour profile. Girls (0.80 (0.64,0.99, participants with siblings (0.76 (0.61,0.94 and those with more highly educated parents (0.73 (0.56,0.94 were less likely to have a poor health behaviour profile.A substantial proportion of children failed to meet guidelines for multiple health behaviours and there was evidence of clustering of screen viewing and unhealthy dietary behaviours. Sub-groups at greatest risk may be targeted for intervention.

  4. 41 CFR 302-9.10 - For what POV emergency storage expenses will my agency pay?

    Science.gov (United States)

    2010-07-01

    ... Federal Travel Regulation System RELOCATION ALLOWANCES TRANSPORTATION AND STORAGE OF PROPERTY 9-ALLOWANCES... expenses, including but not limited to readying the POV for storage, transportation to point of storage, storage, readying the POV for use after storage, and transportation from the point of storage. Insurance...

  5. IAEA INTOR workshop report, groups 2, 5, 7, 9, 10 and 15

    International Nuclear Information System (INIS)

    1980-02-01

    In order to prove scientific feasibility of magnetic confinement fusion, large fusion devices are under construction in several countries (JT-60 in Japan, T-15 in U.S.S.R., TFTR in U.S.A. and JET in EC). International Tokamak Reactor (INTOR) Workshop was organized by the International Atomic Energy Agency (IAEA) to identify roles, objectives and characteristics of the next generation fusion device. This report is a compilation of the home task reports of six groups on INTOR engineering aspects by Japan Atomic Energy Research Institute for workshop sessions 2 and 3 held in 1979. Tasks of the respective groups are group 2: first wall/blanket/shield, group 5: magnetics, group 7: systems integration and structure, group 9: assembly and remote maintenance, group 10: radiation shielding and personnel access, group 15: safety and environment. (author)

  6. Proceedings of Image Understanding Workshop Held at Miami, Florida on 9- 10 December 1985

    Science.gov (United States)

    1985-12-01

    sucn 11 1 turotne blade. In thl’ Piper . our rnter• 11t ia pnmartly rn the dlsc:rlptlon of surteces. though we think thlt aucll deacripttona will...ctlullftl lnstlfVte Tec!WtOiogy Prul. C.mtlondtJII Mala.. 191S s. Betl , P J and Jilin. RC. 1mnnlk: In# ExtnniiC s-taca Chartcten~.tics

  7. Emilie Bláhová (13. 6. 1931 - 9. 10. 2016)

    Czech Academy of Sciences Publication Activity Database

    Chromá, Martina

    2017-01-01

    Roč. 140, 1-2 (2017), s. 275-277 ISSN 0024-4457 Institutional support: RVO:68378017 Keywords : Bláhová, Emilie * obituary * paleoslavistics Subject RIV: AI - Linguistics OBOR OECD: Specific languages

  8. Nuclear power competing (SVA information meeting held in Zurich on September 9-10, 1993)

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    The report summarizes the essential statements of the papers presented at the meeting, following a formal arrangement according to topical aspects, as e.g.: Resources and developmental potentials, environmental impacts, costs, and cost-benefit analysis. (UA) [de

  9. Creep strength of 10 CrMo 9 10 welding material

    International Nuclear Information System (INIS)

    Maile, K.; Theofel, H.

    1993-01-01

    Samples from different welding materials of the heat-resistant steel 10 Cr Mo 10 were subjected to creep tests. The maximum duration of stressing was 36,000 hours. At a text temperature of 450 C, the creep behaviour is considerably affected by different initial strengths. At 500 and 550 C, the creep fracture points for most of the welding materials in the long term range lie scattered in a relatively narrow band. This range is at or just below the lower scatteer band limit of the basic material (corresponding to DIN 17175, mean value ± 20%. (orig.) [de

  10. Academic Training Lectures | The Art of Way Finding | 9-10 December

    CERN Multimedia

    2015-01-01

    Please note that the next series of Academic Training Lectures will take place on 9 and 10 December. The lectures will be given by John Huth (Harvard University (US)).   The Art of Way Finding (1/2) on Wednesday, 9 December from 11 a.m. to 12 p.m. https://indico.cern.ch/event/436443/ The Art of Way Finding (2/2) on Thursday, 10 December from 11 a.m. to 12 p.m. http://indico.cern.ch/event/436444/ at CERN, Council Chamber (503-1-001)  Description: In the modern era we've become accustomed to the instantaneous transfer of information filtered by applications that act as a kind of guardian of information. In the realm of finding one’s way, we use GPS and devices that take us from point A to point B without giving it a second thought. Are we slowly losing the cognitive processes that our ancestors had, and at what price? I use the theme of navi...

  11. Synthesis and Electronic Properties of Length-Defined 9,10-Anthrylene-Butadiynylene Oligomers.

    Science.gov (United States)

    Nagaoka, Maiko; Tsurumaki, Eiji; Nishiuchi, Mai; Iwanaga, Tetsuo; Toyota, Shinji

    2018-05-18

    Linear π-conjugated oligomers consisting of anthracene and diacetylene units were readily synthesized by a one-pot process that involved desilylation and oxidative coupling from appropriate building units. We were able to isolate length-defined oligomers ranging from 2-mer to 6-mer as stable and soluble solids. The bathochromic shifts in the UV-vis spectra suggested that the π-conjugation was extended with elongation of the linear chain. Cyclic voltammetric measurements showed characteristic reversible oxidation waves that were dependent on the number of anthracene units.

  12. 1,5-Diamino-2,6-dibromo-9,10-anthraquinone

    Directory of Open Access Journals (Sweden)

    Wilhelm Seichter

    2012-03-01

    Full Text Available In the title compound, C14H8Br2N2O2, the molecular structure features intramolecular N—H...O [2.639 (2 Å and 130°] and N—H...Br [3.053 (2 Å and 114°] hydrogen bonding. Due to inversion symmetry, the asymmetric part of the unit cell consits of one half-molecule. In the crystal, inversion dimers linked by pairs of N—H...O [2.955 (2 Å and 135°] hydrogen bonds occur. The structure also features C=O...π [3.228 (2 Å] and Br...Br [3.569 (1 Å] contacts.

  13. 1,8-Dihydroxy-2,4,5,7-tetranitro-9,10-anthraquinone

    Directory of Open Access Journals (Sweden)

    Mahsa Armaghan

    2010-05-01

    Full Text Available The ring system in the title compound, C14H4N4O12, is essentially planar (r.m.s. deviation of the carbon atoms = 0.085 Å; the two hydroxy groups form intramolecular hydrogen bonds to the same carbonyl O atom. The nitro groups are twisted with respect to the mean plane of the ring system by 74.3 (1 (1-nitro, 42.3 (3 (3-nitro, 45.7 (3 (6-nitro and 66.9 (1° (8-nitro.

  14. 1,3-Dihydroxy-2-methoxymethyl-9,10-anthraquinone from Rennellia elliptica Korth.

    Directory of Open Access Journals (Sweden)

    Nor Hadiani Ismail

    2009-06-01

    Full Text Available The title compound, C16H12O5, common name: lucidin ω-methyl ether, exists as a planar molecule (r.m.s. deviation = 0.04 Å. Within the molecule, the 1-hydroxy group forms a hydrogen bond to the adjacent carbonyl O atom, and the 3-hydroxy group forms a hydrogen bond to the adjacent methoxy O atom. The methoxy O atom is disordered over two positions of equal occupancy.

  15. An efficient synthesis and spectroscopic characterization of Schiff bases containing 9,10-anthracenedione moiety

    Directory of Open Access Journals (Sweden)

    Fareed Ghulam

    2013-01-01

    Full Text Available A new method has been developed for the synthesis of novel Schiff bases containg anthraquinone moiety using dodeca-Tungstosilicic acid/P2O5 under solvent free conditions at room temperature. The reaction was completed in 1-3 minutes with excellent yields. This method was found to be more efficient, easy and hazardous free for the synthesis of azomethines. The development of these type of methadologies in synthetic chemistry may contribute to green chemistry. The structures of synthesized novel Schiff bases was elucidated using 1H-NMR, 13C-NMR, LCMS, FTIR and CHN analysis.

  16. Proceedings of 1974 National powder metallurgy conference held at Boston, Massachusetts, April 9--10, 1974

    International Nuclear Information System (INIS)

    Halter, R.F.

    1974-01-01

    Papers given at the conference on process variables in production of P/M parts, properties of 316L steel powder, compacts, properties of highly porous Al powder compacts, properties of Cu infiltrated steel powders, uses of P/M Ti and P/M Al alloys, heat treatment of P/M parts, quality control, safety, ultrasonic testing of P/M parts, P/M sealing, cold pressing P/M, properties of AISI 4027 P/M materials, properties of Ni--Mo steel powders, and state of the industry-1974 are presented

  17. is the expulsion of women as foreigners in ezra 9-10 justifiably ...

    African Journals Online (AJOL)

    been viewed variously in Old Testament scholarly circles. ... Others have shared the impression that intermarriage in Ezra's .... covenant between Yahweh and the golah community or the holy race/seed .... Thus, they became foreigners in their own land ... fly in the face of Ezra and his intermarriage reforms (cf Ex 12:49; Lv.

  18. Applications of infrared technology; Proceedings of the Meeting, London, England, June 9, 10, 1988

    International Nuclear Information System (INIS)

    Williams, T.L.

    1988-01-01

    Recent developments in thermal imaging and other infrared systems relating to military, industrial, medical, and scientific applications are reviewed. Papers are presented on a new thermal imager using a linear pyroelectric detector array; multichannel near infrared spectroradiometer; technological constraints on the use of thermal imagery for remote sensing; and infrared optical system of the improved stratospheric and mesospheric sounder. Other topics discussed include infrared thermography development for composite material evaluation; infrared process linescanner, and optical infrared starting radiometer

  19. Military Curricula for Vocational & Technical Education. Club Restaurant Operations, Part II, 9-10.

    Science.gov (United States)

    Army Quartermaster School, Ft. Lee, VA.

    These programmed instructional materials for part 2 of a secondary-postsecondary subcourse in club management operations are one of a number of military-developed curriculum packages selected for adaptation to vocational instruction and curriculum development in civilian settings. This part of the subcourse consists of three lessons and an…

  20. Academic Training Lecture | Big Data Challenges in the Era of Data Deluge | 9 - 10 March

    CERN Multimedia

    2015-01-01

    Big Data Challenges in the Era of Data Deluge, by Ilya Volvovski (Senior Software Architect, Cleversafe, USA).   Monday, 9 March 2015 from 11:00 to 12:00 and Tuesday, 10 March 2015 from 11:00 to 12:00 at CERN ( 4-3-006 - TH Conference Room ) Description: For better or for worse, the amount of data generated in the world grows exponentially. The year of 2012 was dubbed the year of 'Big Data' and 'Data Deluge'; in 2013, the petabyte scale was referenced matter­-of-­factly; and exabyte size is now in the vocabulary of storage providers and large organisations. Traditional copy-based technology doesn’t scale into this size territory: relational DBs give up after many billions of rows in tables; typical file systems are not designed to store trillions of objects; Disks fail; networks are not always available. Yet individuals, businesses and academic institutions demand 100% availability with no data loss. Is this the final dead end? ...

  1. Defense Resource Planning Under Uncertainty: An Application of Robust Decision Making to Munitions Mix Planning

    Science.gov (United States)

    2016-02-01

    Radiation Guided Missile ATACMS Army Tactical Missile System BDA bomb damage assessment C2 command and control CALCM Conventional Air-Launched Cruise Missile...University of Michigan (undated). Figure A.1 Target Selection in WoT 5 6 7 8 9 10 8 6 8 9 10 5 6 7 8 9 10 RAND RR1112-A.1 8 9 10 2 3 3 4 5 6 7 8 9 1 10 BDA ...Follow-on strikesBDA Follow-on strikesBDA Initial strikes Targets in order of priority Follow-on strikes BDA Time Live target Killed

  2. Energy savings interventions for schools: Rome international seminar, October 26-27, 1989. Interventi di miglioramento energetico nelle scuole: Atti del seminario internazionale di Roma, 26-27 ottobre 1989

    Energy Technology Data Exchange (ETDEWEB)

    Giacobbe, M [comp.

    1990-01-01

    In this workshop on energy savings measures for schools, 21 papers were presented. Key topics included the following: ENEA (Italian Commission for Nuclear and Alternative Energy Sources) activities (research, demonstration projects, surveys, etc.); research activities by other Italian research institutes; school building energy efficiency surveys and heating system retrofitting programs conducted in Italy, Germany and England; energy efficiency monitoring techniques; solar architectural techniques; solar water heating and efficient lighting techniques.

  3. ExcelNet Concept Papers. Volume 1.

    Science.gov (United States)

    1985-10-01

    Interservice sports coUpetitions. Post baseball, men’s and women’s basketball, and rugby teams had outstanding seasons, and the boxing team is world class...enter 5.) B1 . Performance 1 2 3 4 5 6 7 8 9 10 B2. Potential 1 2 3 4 5 6 7 8 9 10 ,q . BI + B2 B _" ._- C. Rater Cl. Performance 1 2 3 4 5 6 7 8 9 10

  4. The synthesis of 10-halo-substituted derivatives of nido-7,8,9-PC2B8H11 and [nido-7,8,9-PC2B8H10]- and new linear correlations between NMR parameters

    Czech Academy of Sciences Publication Activity Database

    Holub, Josef; Bakardjiev, Mario; Štíbr, Bohumil

    2005-01-01

    Roč. 70, č. 11 (2005), s. 1861-1872 ISSN 0010-0765 R&D Projects: GA MŠk(CZ) LC523 Institutional research plan: CEZ:AV0Z40320502 Keywords : boron * carboranes * borane cluster Subject RIV: CA - Inorganic Chemistry Impact factor: 0.949, year: 2005

  5. Conference on Teacher Certification; Current Problems in Certification and Prospects for Reciprocity (2nd, Montreal, June 8-9, 1970).

    Science.gov (United States)

    Canadian Teachers' Federation, Ottawa (Ontario).

    This report contains the proceedings of a 2-day interprovincial conference attended by 38 teachers, registrars, university professors, and trustees to discuss means of reducing the complexity of teacher certification regulations and of enabling teachers to move more freely among the various provinces. Included are four presentations on the…

  6. Active site specificity profiling datasets of matrix metalloproteinases (MMPs 1, 2, 3, 7, 8, 9, 12, 13 and 14

    Directory of Open Access Journals (Sweden)

    Ulrich Eckhard

    2016-06-01

    Full Text Available The data described provide a comprehensive resource for the family-wide active site specificity portrayal of the human matrix metalloproteinase family. We used the high-throughput proteomic technique PICS (Proteomic Identification of protease Cleavage Sites to comprehensively assay 9 different MMPs. We identified more than 4300 peptide cleavage sites, spanning both the prime and non-prime sides of the scissile peptide bond allowing detailed subsite cooperativity analysis. The proteomic cleavage data were expanded by kinetic analysis using a set of 6 quenched-fluorescent peptide substrates designed using these results. These datasets represent one of the largest specificity profiling efforts with subsequent structural follow up for any protease family and put the spotlight on the specificity similarities and differences of the MMP family. A detailed analysis of this data may be found in Eckhard et al. (2015 [1]. The raw mass spectrometry data and the corresponding metadata have been deposited in PRIDE/ProteomeXchange with the accession number http://www.ebi.ac.uk/pride/archive/projects/PXD002265.

  7. 78 FR 40128 - Notice of Intent to Prepare a Draft Environmental Impact Statement (EIS) for the Reaches 8, 9...

    Science.gov (United States)

    2013-07-03

    ... to R-134+135. The Town proposes to place approximately 74,300 cubic yards of beach quality sand in... beach quality sand is proposed to be placed between R-134+135 and R-135+551 to elevate the existing berm... and dune restoration projects between R-128+955 and R-138+551 with sand placement and the construction...

  8. Amistad Symposium on Southern Civil Rights Litigation Records for the 1960s (New Orleans, Louisiana, December 8-9, 1978).

    Science.gov (United States)

    Dillard Univ., New Orleans, LA. Armistad Research Center.

    This report contains transcripts of speeches given at the Amistad Symposium by lawyers, judges, and others active in the civil rights movement since the 1960s. Speakers include Clifton Johnson, J. Skelly Wright, John P. Nelson, Edwin King, Fred L. Banks, Jr., Lawrence A. Aschenbrenner, Frank R. Parker, Henry Schwarzschild, and Richard B. Sobol.…

  9. Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany.

    Science.gov (United States)

    Gröttrup, Bernd; Böckmann, Miriam; Marcus, Katrin; Wiltfang, Jens; Grinberg, Lea T; Meyer, Helmut E; Park, Young M

    2011-11-01

    The HUPO Brain Proteome Project (HUPO BPP) held its 15th workshop in Bochum, Germany, from April 8th to 9th, 2011 directly after the Proteomic Forum 2011 in Berlin. Like on every spring workshop, the focus was more on clinical aspects, so that especially clinicians participated in this workshop. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. 2017 Global Explosive Ordnance Disposal (EOD) Symposium and Exhibition. Held in North Bethesda, MD on 8-9 August 2017.

    Science.gov (United States)

    2017-08-09

    45 AM Keynote Address: Technology Innovation to Counter Improvised Threats and DTRA Integration Update • LTG Michael Shields, USA, Director...10:00 AM Networking Break EOD Silent Auction Opens Salons A-E 10:00 AM - 10:30 AM JIDO Technology Outreach Session: JIDO Overview and Counter...SYMPOSIUM & EXHIBITION AUGUST 7-9, 2017 AGENDA 10:30 AM - 11:15 AM EODWF State of the Foundation and Warrior Panel: Personal Stories of Growth

  11. Research project: State and Stimulation of Developmet in Chidren Aged 8-9 Living Under War Conditions

    Directory of Open Access Journals (Sweden)

    M. Vranešić

    1998-02-01

    Full Text Available The somatic, functional and metabolic characteristics of children at 8 years of age have been established. These children have, for the previous three years, lived under stressful conditions of direct shelling, poor nutrition and movement. At the same time there has been an evaluation of the effects of programmed physical activities which have been applied in the aim of stimulating natural physical dynamics and functional developments and the elimination of stagnation of development which occurs from conditions of unfavorable factors. The research and the program of physical activities included 41 boys, starting at an average age of 8 years and four months. The somatic characteristics of the boys, according to 25 antropo-metric measures (IBP, show a lag in the boy’s physical development according to their age group by one year. The lagging behind is especially evident in volume dimensions and underskin tissue fat (Przulj, 1991., Bonacin, 1995. Blaha, 1982.. An improvement of conditions and a greater scope of movement activities for the duration of 8 months did not significantly influence on the improvement of the somatic and functional status of the boys in comparison with the controlled group (N=21 of the same average age during another measurement period. While resting, on the level of aerobic threshold, anaerobic threshold and maximal oxygen uptake, the value of ergonometric, functional and metabolic parameters were confirmed: V02 stpd, Ve btps. Ve * V02-1, Ve*VC02-l, RQ, fc (beats*min-l, work load in Watts and on the basis of these relative indicators were completed. The gradual growth of work load was completed with the help of bicyklergometer (Monark. After 3 minutes of easy pedaling (warming-up an initial work load was given of Watt*body mass and increased by 1/3 of the mass*Watt every minute until the achievement of maximal oxygen uptake. Individual aerobic and anaerobic thresholds (Aep and (Anp, for each person examined were confirmed on the basis of the smallest sizes in the points of the crucial curves Ve*V02-l and Ve*VC02-l (Wasserman et al., 1973 and 1991, Cooper et al, 1984, Yacov, 1991. For the level of maximum oxygen uptake, the work load was taken, on which the greatest worth of V02 was achieved and it did not increase with the foflowing greater work load. The average value of ergono-metric, functional and metabolic parameters of the initial state and the final measurement of the experiment group: -level of aerobic threshold: 2.4 and 2.3 work load (Watt*mass-1, 30.57 and 28.37 V02kg(ml*kg-1 *min-I, 168.6 and 166.6 fc(beats*min-l, 5.08 and 5.31 V02*fc-1, 64.7 ad 62.6 V02*V02 max-1 %, 85.9 and 85.4 fc*fc(V02max-l %, 63.4 and 62.6 W*W(V02max-l%,-level of anaerobic threshold: 2.7 and 2.7 work load (Watt*mass-1, 33.15 and 34.54 V02 kg(ml*kg-l*min-1, 175.4 and 175.7 fc (beats*min-l, 5.6 and 6.1 V02*fc-I, 74.4 and 76.2 V02*V02max-l%, 89.3 and 90.1 fc*fc(V02max, 70.7 and 72.7 W*W(V02max-1%,-level of maximum oxygen uptake: 3.8 and 3.7 work load (Watt*mass-1, 47.2 and 45.3 V02kg(ml*kg-l*min-l, 196.3 and 195.1 fc(beats*min-l, 6.8 and 7.3 V02*fc-1. Significant statistical differences are confirmed only on the values of V02* fc-1 I and II measuring Ρ = 001.The results confirm the assumption of the general stråte-gy of adaptation, directed in the formation and protection of functional reserves from exhaustion, for priority of growth needs and development and only on that basis can an increase of ability for an even greater level of their total and rational usage can occur. For a significant growth ability of a greater level of mobilization of functional reserves there is a need for a greater intensity and a longer time period in completing physical activities.

  12. Differences in neurocognitive aspects of dyslexia in Dutch and immigrant 6-7- and 8-9-years old children.

    Science.gov (United States)

    Verpalen, Johanna Mp; van de Vijver, Fons Jr

    2015-01-01

    Detecting dyslexia in immigrant children can be jeopardized because of assessment bias, as a consequence of a limited word lexicon or differences in language development of these children. This is in contrast with the view of the universal neurocognitive basis for dyslexia. In this research, differences in screening children at risk for dyslexia with the Dyslexia Screening Test (DST) were studied in third and fifth graders of primary school of Dutch (mainstream) and immigrant descent. Mean group differences were found on a few subtests (Naming Letters, Semantic Fluency, Backward Digit Span and Verbal Fluency), probably as a consequence of bias because of the linguistic character of these subtests. The raw scores of word lexicon increased in the Dutch and immigrant group. The association of having a dyslexia diagnosis on DST scores was comparable for Dutch and immigrant children. Differences in the DST scores between non-dyslexic and dyslexic children were found between the third and fifth grade, with a stronger effect of having a dyslexia diagnosis in the fifth grade than the third grade, for Dutch as well as immigrant children. Screening of dyslexia seems easier in the fifth grade than in the third grade, dyslexic children show a slower reading development than their non-dyslexic peers, irrespective of their cultural background.

  13. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy: 4, Transportation and the City, Grades 8, 9.

    Science.gov (United States)

    Childs, Barbara; And Others

    This instructional unit for grades eight and nine tells why and how American small towns declined as a result of the availability and acceptance of automobiles, and it tells of the growth of suburbs and their effect on the city. The learning activities also relate the story of the demand for cars and explain the drain on the cities' sense of…

  14. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy: Mathematics in Energy, Grades 8-9.

    Science.gov (United States)

    Brown, Evelyn; And Others

    This publication is part of a series of instructional units produced by NSTA's Project for an Energy-Enriched Curriculum. The teacher's manual and the student guide for a mathematics unit in this series are presented here. This unit attempts to teach students some necessary mathematical skills needed to understand quantitative facts about energy.…

  15. International conference on access to civil nuclear energy, March 8-9, 2010, at the OECD, Paris

    International Nuclear Information System (INIS)

    2010-01-01

    The conference on the access to civil nuclear energy gathered representatives of 65 countries. The aim of the conference was to debate about the different aspects of the elaboration of a civil nuclear program, on the existing bilateral and multilateral cooperation means, and on the respect of international obligations of security and safety. This document summarizes the highlights of the opening session with the talk of the French President N. Sarkozy, and the opinions expressed during three round tables about: the financing of nuclear programs, the framework of a responsible use of nuclear energy, and the cooperation between nuclearized countries and newcomers. The conclusion of the conference was presented by the French Prime Minister F. Fillon. (J.S.)

  16. 4,10-Diallyloxy-1,2,3,6b,7,8,9,12b-octahydroperylene

    Directory of Open Access Journals (Sweden)

    Terrill D. Smith

    2010-01-01

    Full Text Available In the title compound, C26H28O2, the central atoms are coplanar, with the –CH2—CH2– links of the cyclohexene groups lying to either side of the plane and with the diallyloxy residues twisted out of this plane [C—C—O—C torsion angles = 16.6 (3 and −13.9 (3°]. In the crystal structure, molecules are connected into chains propagating in [100] via C—H...π interactions.

  17. Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis

    DEFF Research Database (Denmark)

    Natsume, Toyoaki; Nishimura, Kohei; Minocherhomji, Sheroy

    2017-01-01

    stemming from replisome dissociation during DNA replication perturbation, we used a degron-based system for inducible proteolysis of a subunit of the replicative helicase. We show that MCM2-depleted cells activate a DNA damage response pathway and generate replication-associated DNA double-strand breaks...

  18. Proceedings of the ATB Model Users Group Conference Held in Phoenix, Arizona on 8-9 February 1996.

    Science.gov (United States)

    1996-02-09

    310 Lookout Dr. Laguna Beach, CA 92651 Phone: 714-497-8446 Fax: 714-497-7013 E-mail: Dr. Kenneth J Saczalski Environmental Research & Safety...Technologists 310 Lookout Drive Laguna Beach, CA 92651 Phone: 714-497-8446 Fax: 714-497-7013 E-mail: Mr. Michael Shanahan BTS Consulting Engineers 1725 North...Weisenfeld Honda R&D 1900 Harpers Way Torrance, CA 90501 Phone: 310-781-5844 Fax: E-mail: Dr Narayan Yoganandan Medical College of Wisconsin

  19. Ninth meeting of the International Working Group on Gas Cooled Reactors, Oak Ridge, USA, 8-9 November 1990

    International Nuclear Information System (INIS)

    1991-05-01

    This report contains the minutes of the meeting, the papers presented as overview of the national programmes in the field of gas-cooled reactors and the main results from discussions on the different items of the agenda. The meeting was attended by 20 members and/or alternates from 9 countries and 2 international organizations. 8 papers were presented. A separate abstract was prepared for each of these papers. Refs, figs and tabs

  20. Invitational Conference on Measurement in Education; Proceedings (of the) Eleventh Southeastern Conference (December 8-9, 1972). Pre-Session.

    Science.gov (United States)

    Goolsby, Thomas M., Jr., Comp.

    Three papers presented at the pre-session to the 11th Invitational Conference on Measurement in Education are provided. These papers are: "Public Schools in Transition. . . One Student Body, Its Needs and Directions" by George R. Rhodes, Jr., "Man to Mankind: The International Dimension of Teacher Education" by David G. Imig, and "Measurement for…

  1. Di-μ-chlorido-bis{[μ-1,8-bis(diisopropylphosphanyl-9,10-dihydro-9,10-ethanoanthracene-κ2P:P′]-μ-chlorido-μ-methylidene-dipalladium(II} tetrahydrofuran pentasolvate

    Directory of Open Access Journals (Sweden)

    Thomas Schnetz

    2010-04-01

    Full Text Available The title compound, [Pd4(CH22Cl4(C28H40P22]·5C4H8O, possesses a tetranuclear palladium core with four bridging chlorido ligands and two bridging methylene units, as well as two bridging anthracene-based bis-phosphine ligands. This tetranuclear complex can be considered as being composed of two μ-chlorido-bridged LPd2 units. The structural motif of these LPd2 units shows two doubly bridged palladium centers between the P atoms of the bis-phosphine ligand. One of these bridges is a μ-Cl atom, the other a μ-methylene group. The coordination environment around each palladium center is essentially square planar. We ascribe the oxidation state +II to the palladium centers and do not assume Pd—Pd bonds [shortest distances 2.8110 (5 and 2.8109 (6 Å]. Co-crystallized with the palladium complex we found five non-coordinating tetrahydrofuran solvent molecules, one of which is disordered over two positions in a 0.429 (9:0.571 (8 ratio.

  2. CCDC 945081: Experimental Crystal Structure Determination : 9-(bis(4-t-butylphenyl)methylene)-10-(10-(bis(4-t-butylphenyl)methylene)anthracen-9(10H)-ylidene)-9,10-dihydroanthracene dichloromethane solvate

    KAUST Repository

    Zeng, Zebing; Sung, Young Mo; Bao, Nina; Tan, Davin; Lee, Richmond; Zafra, José L.; Lee, Byung Sun; Ishida, Masatoshi; Ding, Jun; Navarrete, Juan T. Ló pez; Li, Yuan; Zeng, Wangdong; Kim, Dongho; Huang, Kuo-Wei; Webster, Richard D.; Casado, Juan; Wu, Jishan

    2013-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  3. Intercalation of 2 - Naphtol - 3,6 - disulfonate, 9,10 - Anthraquinone - 2,6 - disulfonate, and 9,10 - Anthraquinone - 2 - sulfonate Anions into Zn - Al Layered Double Hydroxide

    Czech Academy of Sciences Publication Activity Database

    Beneš, L.; Zima, Vítězslav; Svoboda, Jan; Melánová, Klára

    2005-01-01

    Roč. 53, č. 1-2 (2005), s. 41-46 ISSN 0923-0750 R&D Projects: GA ČR(CZ) GA203/05/2306 Institutional research plan: CEZ:AV0Z40500505 Keywords : intercalate Subject RIV: CA - Inorganic Chemistry Impact factor: 1.020, year: 2005

  4. Physical Aspects of Light--"Seeing Parameters". Lighting Techniques in Architecture (Madison, December 9-10, 1969).

    Science.gov (United States)

    Turek, Robert W.

    In order to judge or design the lighting of an interior a person must be able to understand and take into account many aspects of seeing and illumination. Important areas of consideration are--(1) factors that contribute to the visibility of an object: size, brightness, contrast, and time, (2) radiant energy with regard to the visible spectrums of…

  5. Ultrafast Transient Absorption Spectroscopy Investigation of Photoinduced Dynamics in POLY(3-HEXYLTHIOPHENE)-BLOCK-OLIGO(ANTHRACENE-9,10-DIYL)

    Science.gov (United States)

    Strain, Jacob; Rathnayake, Hemali; Liu, Jinjun

    2017-06-01

    Semiconducting polymer nanostructures featuring bulk heterojunction (BHJ) architecture are promising light harvesters in photovoltaic (PV) devices because they allow control of individual domain sizes, internal structure and ordering, as well as well-defined contact between the electron donor and acceptor. Power conversion efficiency (PCE) of PV devices strongly depends on photoinduced dynamics. Understanding and optimizing photoinduced charge transfer processes in BHJ's hence help improve the performance of PV devices and increase their PCE in particular. We have investigated the photoinduced dynamics of a block polymer containing moieties of poly-3-hexylthiophene (P3HT) and polyanthracene (PANT) in solution and in solid state with femtosecond transient absorption (TA) spectroscopy. The dynamics of the polymer PANT alone are also studied as a control. The TA spectra of PANT includes a strong excited state absorption centered at 610 (nm) along with a stimulated emission signal stretching past the detection limit into the UV region which is absent in the monomer's spectra in the detection window. The block polymer's TA spectra strongly resembles that of P3HT but a noticeable positive pull on P3HT's stimulated emission signal residing at 575-620 (nm) is indicative of the excited state absorption of PANT in the adjacent spectral region. The doubling of the lifetime exciton delocalization on the block polymer versus P3HT alone have alluded that the lifetime of P3HT is extended by the covalent addition of PANT. The current spectroscopic investigation represents an interesting example of photoinduced processes in systems with complex energy level structure. Studies of dependence of change generation and separation on composition, dimension, and morphology of the heterojunctions are in process.

  6. Enthesopathies and activity patterns in the early medieval greater moravian population (9.- 10. century AD). Evidence of division of labour

    Czech Academy of Sciences Publication Activity Database

    Havelková, P.; Villote, S.; Velemínský, P.; Poláček, Lumír; Dobisíková, M.

    2011-01-01

    Roč. 21, č. 4 (2011), s. 487-504 ISSN 1047-482X Institutional research plan: CEZ:AV0Z80010507 Keywords : enthesopathies * occupational stress markers * Great Moravia Empire Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.955, year: 2011

  7. 77 FR 17386 - Significant New Use Rule for Hexabromocyclododecane and 1,2,5,6,9,10-Hexabromocyclododecane

    Science.gov (United States)

    2012-03-26

    ...., 2006). HBCD has been reported to reduce egg production and lower biomass in soil dwelling organisms... and thyroid function (Crump, et al., 2008). Thinner egg shells were measured in American kestrels...

  8. A North Carolina Model for Improving Rural Health Care: 1/10 Albert Schweitzer, 9/10 ORHS.

    Science.gov (United States)

    Coogan, Mercy Hardie

    1980-01-01

    The article describes North Carolina's precedent setting Office of Rural Health Services, its background and design, and its significant role in the development of primary health care clinics such as that in Balsom Grove which is staffed by a family nurse practitioner and enjoying wide community support. (SB)

  9. Electronic states of the fluorophore 9,10-bis(phenylethynyl)anthracene (BPEA). A synchrotron radiation linear dichroism investigation

    DEFF Research Database (Denmark)

    Thulstrup, Peter Waaben; Jones, Nykola; Hoffmann, Søren Vrønning

    2013-01-01

    temperature spectroscopy and by quantum chemical calculations in the LCOAO and TD-DFT models. The combined experimental and theoretical evidence leads to characterization of several previously unobserved transitions and provides a revised polarization analysis of the visible absorption band of BPEA....

  10. 5,6-Dimethyl-1,2,9,10-tetrahydropyrano[3,2-f]chromene-3,8-dione

    Directory of Open Access Journals (Sweden)

    Shailesh K. Goswami

    2012-07-01

    Full Text Available The title molecule, C14H14O4, lies on a twofold rotation axis that bisects the central benzene ring, with only one half-molecule in the asymmetric unit. The pyranone systems adopt distorted twist- boat conformations, with the two methylene C atoms displaced by 0.537 (1 and 0.163 (2 Å from the best-fit plane through the remaining five C and O atoms (r.m.s. deviation = 0.073 Å. In the crystal, bifurcated C—H...(O,O hydrogen bonds link pairs of adjacent molecules in an obverse fashion, stacking molecules along c. These contacts are further stabilized by very weak π–π interactions between adjacent benzene rings with centroid–centroid distances of 4.1951 (4 Å. Additional C—H...O contacts link these stacks, giving a three-dimensional network.

  11. Estimation of peak oxygen uptake from maximal power output among 9-10 year-old children in Lhasa, Tibet

    DEFF Research Database (Denmark)

    Bianba, B; Berntsen, S; Andersen, Lars Bo

    2010-01-01

    with the equations from the present study. None of the three could accurately predict the direct measured V.O2peak, and predictions differed in an unsystematic manner, including over- or underestimation and no differentiation between genders. CONCLUSION: Peak oxygen uptake could be estimated from Wmax and sex...

  12. 9 -10 klasių merginų fizinio savivaizdžio formavimo(-si) veiksniai

    OpenAIRE

    Butkienė, Roma

    2006-01-01

    Summary PHYSICAL SELF – IMAGE FORMATION FACTORS OF 9 – 10 FORMERS Intense social, economic, political and transformational processes, ongoing in the Western Europe, induce changes in the general culture, influencing changes in the body culture as a subject. Physical activity becomes a healthy way of life, new lifestyle, when self-image is shaped through body. In the work I describe the psychological, biological and social factors, influencing girls’ body self-image shaping. The gro...

  13. Proceedings of the Guidelines for Seismometer Testing Workshop, Albuquerque, New Mexico, 9-10 May 2005 ("GST2")

    Science.gov (United States)

    Hutt, Charles R.; Nigbor, Robert L.; Evans, John R.

    2009-01-01

    Testing and specification of seismic and earthquake-engineering sensors and recorders has been marked by significant variations in procedures and selected parameters. These variations cause difficulty in comparing such specifications and test results. In July 1989, and again in May 2005, the U.S. Geological Survey hosted international public/private workshops with the goal of defining widely accepted guidelines for the testing of seismological inertial sensors, seismometers, and accelerometers. This document reports the Proceedings of the 2005 workshop and includes as Appendix 6 the report of the 1989 workshop. In a future document, we will attempt to collate and rationalize a single set of formal guidelines for testing and specifying seismic sensors, supplementing Advanced National Seismic System (ANSS) guidelines on instrumentation likely used by ANSS as its standard for verification, acceptance, and intermittent testing, as well as for responses to ANSS instrument requisitions.

  14. Proceedings of workshop on the social consequences of waste heat discharge alternatives, Argonne, Illinois, June 9--10, 1975

    International Nuclear Information System (INIS)

    Butz, B.P.; Lewis, B.A.G.; Friesema, H.P.; Halter, A.N.

    1975-08-01

    The workshop was attended by individuals representing federal regulatory and research agencies, universities, private industry, and citizen interest groups. The staff presented papers on quantification of social consequences, environmental considerations, social considerations, and economic considerations. Participant recommendations were made with regard to the impact matrix technique, technology assessment, and the program philosophy. The principal recommendations were that site specific cases be analyzed, careful extrapolation of results be made region by region, generic impact matrices be handled very carefully or avoided, and methodology development be initiated

  15. Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney.

    Science.gov (United States)

    Drake, Keri A; Adam, Mike; Mahoney, Robert; Potter, S Steven

    2018-04-20

    Hox genes are important regulators of development. The 39 mammalian Hox genes have considerable functional overlap, greatly confounding their study. In this report, we generated mice with multiple combinations of paralogous and flanking Abd-B Hox gene mutations to investigate functional redundancies in kidney development. The resulting mice developed a number of kidney abnormalities, including hypoplasia, agenesis, and severe cysts, with distinct Hox functions observed in early metanephric kidney formation and nephron progenitor maintenance. Most surprising, however, was that extensive removal of Hox shared function in these kidneys resulted in cellular level lineage infidelity. Strikingly, mutant nephron tubules consisted of intermixed cells with proximal tubule, loop of Henle, and collecting duct identities, with some single cells expressing markers associated with more than one nephron segment. These results indicate that Hox genes are required for proper lineage selection/maintenance and full repression of genes involved in cell fate restriction in the developing kidney.

  16. International Conference on Artificial Immune Systems (1st) ICARIS 2002, held on 9, 10, and 11 September 2002

    Science.gov (United States)

    2002-03-07

    now become the dominating theme for a number of new proteomics technologies. Based on this principle, two main systems are currently used for analysis...bactaerium, fungus or other parasite. For an artificial immune system a complete data item represents a pathogen. ii) Antigen: a real antigen is a

  17. Photochemical reaction of triplet 9,10-anthraquinone with ethylbenzene in the presence of DPPH as a radical trapping agent

    International Nuclear Information System (INIS)

    Moger, G.

    1983-01-01

    DPPH was used as a scavenger of α-phenyl-ethyl radicals produced in the photochemical reaction between triplet anthraquinone (Qsup(T)) and ethylbenzene (RH 2 ) in benzene solutions. The rate constant ratio ksub(2)/ksub(-1) was determined from the measurements of the quantum yield of scavenging against (RH 2 ) and found to be (0.49+-0.015) M at 25 deg C. (author)

  18. Characteristics of modern Gleason 9/10 prostate adenocarcinoma: a single tertiary centre experience within the Republic of Ireland.

    LENUS (Irish Health Repository)

    O'Kelly, F

    2014-08-01

    The 2005 international society of urological pathology consensus statement on Gleason grading in prostate cancer revised Gleason scoring in clinical practice. The potential for grade migration with this refinement poses difficulties in interpreting historical series. We report the characteristics of a recent cohort of consecutive Gleason score 9 or 10 prostate cancers in our institution. The purpose of this study was to define the clinicopathologic variables and staging information for this high-risk population, and to identify whether traditional prostate staging techniques are adequate for this subcohort of men.

  19. Proceedings of the Natick Science Symposium (4th) Held in Natick, Massachusetts on 9-10 June 1992

    Science.gov (United States)

    1992-09-01

    and has a UV absorption maximum of 285 nm. M-1 was observed from a variety of food categories (meats, vegetables, fruits, extruded products and bread...Mark Nonnand, Mr., Micha Peleg, Dr. , Edward Ross, Dr. ABSTRAcr: Porous foods, such as extruded , ba.ke:l, or foamed products, have highly cc::ttplex...foods, particularly that of "crunchy" snack - type products, is not a single attribute, but a property associated with deformation of many irrlividual

  20. Proovisõidud mälupaadis / Teet Kallas

    Index Scriptorium Estoniae

    Kallas, Teet, 1943-

    1999-01-01

    Järg Sep/7,8,9,10,11,13,14,15,16,17,18,20,21,22,23,24,25,27,28,29,30 Oct/1,2,3,5,6,7,8,9,11,12,13,14,15,16,18,19,20,21,22,23,25,26,27,28,29,30 Nov/1,2,3,4,5,6,8,9,10,11,12,13,15,16,17,18,19,20. Sündmused 10 aastat tagasi

  1. Proceedings of the Symposium of Medical (Ophthalmic) Surveillance of Personnel Potentially Exposed to Laser Radiation Held on 8-9 September 1982.

    Science.gov (United States)

    1982-01-01

    because of maxillary sinus cancer was exposed to a relatively low-energy pulsed ruby laser in 1964 at a distance of about 150 m. The man reported only a...functionally regardless of the appearance of the retina? The answer, I think, is yes. If we only test for function and do not become distracted by

  2. The association of birth weight and infant growth with physical fitness at 8-9 years of age-the ABCD study

    NARCIS (Netherlands)

    van Deutekom, A.W.; Chin A Paw, M.J.M.; Vrijkotte, T.G.M.; Gemke, R.J.B.J.

    2015-01-01

    Background:Low birth weight and accelerated infant growth are independently associated with childhood obesity. We hypothesized that birth weight and infant growth are associated with physical fitness in childhood, and thereby could act as a link in the developmental origins of obesity. In addition,

  3. Proposed tandem mirror research program for FY87 presented to the MFAC subcommittee on mirror research, July 8-9, 1986

    International Nuclear Information System (INIS)

    Baldwin, D.E.; Correll, D.L.; Fowler, T.K.; Grubb, D.P.; Hershkowitz, N.; Porter, G.D.; Post, R.S.; Simonen, T.C.

    1986-01-01

    We have reexamined the goal of approx.10 13 cm -3 central-cell density with end-plugging and reconfirmed its importance as a test of thermal barrier end-plugging performance in either Tara or TMX-U. We conclude that, when all factors are considered including the impact on other programs interlinked with LLNL in the present OFE budget, the lowest cost approach to have a fair chance to meet this goal is to extend Tara operation for the full FY87. Continuation of TMX-U operation in FY87, in addition to the full year of Tara operation, would greatly improve the chance of success. Continuation of the mirror program into FY88 and beyond would be based on an experimental program in TMX-U and Tara at a minimum budget level of $25M/y, with restart of MFTF-B requiring an increase in the national fusion budget. The experimental program to be investigated by TMX-U and Tara would include improvement in the mgnetic geometry (stability, beta limits, and transport), continued plug studies (longer pulse length, impurities, drift pumping, and ECH efficiency), and transport studies (chi/sub e/, fueling, and halo formation)

  4. Proceedings of the National Forum on Human Resources Planning (2nd) Held in McLean, Virginia on 8-9 May 1986.

    Science.gov (United States)

    1986-05-09

    34 Successful author John Naisbitt ( Megatrends ) supplies us both with hope, common sense observations on current trends, and enriches our vocabulary...program. At this point, biological tests will almost certainly indicate that a problem exists. The same tests, done earlier, would not necessarily...somewhat better. ACCURACY AND PREDICTIVE VALUE OF ANY TEST PROCEDURE The use of biological tests to determine whether an employee is using I alcohol or

  5. HbA(1c) levels in non-diabetic Dutch children aged 8-9 years : the PIAMA birth cohort study

    NARCIS (Netherlands)

    Jansen, H.; Wijga, A. H.; Smit, H. A.; Scholtens, S.; Kerkhof, M.; Koppelman, G. H.; de Jongste, J. C.; Stolk, R. P.

    Glycated haemoglobin (HbA(1c)) is considered the best index of glycaemic control in established diabetes. It may also be useful in the diagnosis of diabetes and as a screening tool. Little is known about the distribution of HbA(1c) in healthy children and its predictors. The aim of this study is to

  6. Salinity and temperature data collected by bottle from multiple cruises from 8/9/1926 - 11/02/1989 (NODC Accession 0000048)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using bottle casts from PERSEY in a world wide distribution. Data were collected from 09 August 1926 to 02 November 1989....

  7. Nanotechnology and the Environment: Report of a National Nanotechnology Initiative Workshop Held in Arlington, Virginia on 8-9 May 2003

    Science.gov (United States)

    2007-01-01

    impact on these needs by stimulating related biological research. This research will help identify, quantify, and predict ecological effects on...distributed emission sources, represents another opportunity. The needs also can be addressed by developing broader ecological aspects of nanoscale...in which prefabricated “nano-elements” are constructed (such as nanowires or nanotubes that are modified with specific chemical or biomolecular

  8. Aerospace Technologies of the 21st Century: New Technologies of Experimental Research and Simulation Held in Berlin, Germany on 8-9 June 2000

    Science.gov (United States)

    2000-01-01

    providing the same real mass- inertia characteristics and used for determination of non-steady characteristics and stability characteristics, are...prone to model dynamics. Therefore, some aspects of model vibrations are discussed in the following paragraphs. The model/balance/sting/ sector /model...or group of states are able to construct the system of glo- bal rescue on the basis of the offered aeroballis - tic delivery system, because there

  9. Joint National Symposium on the Influence of Aviation on Engineering and the Future of Aeronautics in Australia, Melbourne, Australia, August 8, 9, 1985, Preprints and Supplementary Papers

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The present conference considers computer-integrated manufacturing, the manufacture of bonded composite assemblies for aircraft, advancements in the condition monitoring of gears and rolling element bearings, condition monitoring of large commercial turbofan engines, novel gas turbine materials, and advanced fiber-reinforced composites for airframe applications. Also discussed are the future of air power in the defense of Australia, future procurement and operations of rotary wing aircraft in the Royal Australia Navy, the future balance between Australian aerospace-related education, research and industry, and the educational requirements for the Royal Melbourne Institute of Technology aeronautical engineering degree.

  10. A Cultural Resources Inventory and Historical Evaluation of the Smoky Atmospheric Nuclear Test, Areas 8, 9, and 10, Nevada National Security Site, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Robert C. [Desert Research Inst. (DRI), Reno, NV (United States); King, Maureen L. [Desert Research Inst. (DRI), Reno, NV (United States); Beck, Colleen M. [Desert Research Inst. (DRI), Reno, NV (United States); Falvey, Lauren W. [Desert Research Inst. (DRI), Reno, NV (United States); Menocal, Tatianna M. [Desert Research Inst. (DRI), Reno, NV (United States)

    2014-09-01

    This report presents the results of a National Historic Preservation Act Section 106 cultural resources inventory and historical evaluation of the 1957 Smoky atmospheric test location on the Nevada National Security Site (NNSS). The Desert Research Institute (DRI) was tasked to conduct a cultural resources study of the Smoky test area as a result of a proposed undertaking by the Department of Energy Environmental Management. This undertaking involves investigating Corrective Action Unit (CAU) 550 for potential contaminants of concern as delineated in a Corrective Action Investigation Plan. CAU 550 is an area that spatially overlaps portions of the Smoky test location. Smoky, T-2c, was a 44 kt atmospheric nuclear test detonated at 5:30 am on August 31, 1957, on top of a 213.4 m (700 ft) 200 ton tower (T-2c) in Area 8 of the NNSS. Smoky was a weapons related test of the Plumbbob series (number 19) and part of the Department of Defense Exercise Desert Rock VII and VIII. The cultural resources effort involved the development of a historic context based on archival documents and engineering records, the inventory of the cultural resources in the Smoky test area and an associated military trench location in Areas 9 and 10, and an evaluation of the National Register eligibility of the cultural resources. The inventory of the Smoky test area resulted in the identification of structures, features, and artifacts related to the physical development of the test location and the post-test remains. The Smoky test area was designated historic district D104 and coincides with a historic archaeological site recorded as 26NY14794 and the military trenches designed for troop observation, site 26NY14795. Sites 26NY14794 and 26NY14795 are spatially discrete with the trenches located 4.3 km (2.7 mi) southeast of the Smoky ground zero. As a result, historic district D104 is discontiguous and in total it covers 151.4 hectares (374 acres). The Smoky test location, recorded as historic district D104 and historic sites 26NY14794 and 26NY14795, is the best preserved post-shot atmospheric nuclear tower test at the NNSS and possibly in the world. It is of local, national, and international importance due to nuclear testing’s pivotal role in the Cold War between the United States and the former Soviet Union. The district and sites are linked to the historic theme of atmospheric nuclear testing. D104 retains aspects of the engineering plan and design for the Smoky tower, instrument stations used to measure test effects, German and French personnel shelters, and military trenches. A total of 33 structures contribute to the significance of D104. Artifacts and features provide significant post-test information. Historic district D104 (discontiguous) and historic site 26NY14794 (the Smoky test area) are eligible for listing on the NRHP under Criteria A, B, C, and D. The historic site 26NY14795 (the Smoky military trenches) is eligible for listing under Criteria A, C, and D. Several items have been identified for removal by the CAU 550 investigation. However, none of them is associated with the Smoky atmospheric test, but with later activities in the area. The military trenches are not part of CAU 550 and no actions are planned there. A proposed closure of the Smoky test area with restrictions will limit access and contribute to the preservation of the cultural resources. It is recommended that the Smoky historic district and sites be included in the NNSS cultural resources monitoring program.

  11. Observations of the Breakdown of Mountain Waves Over the Andes Lidar Observatory at Cerro Pachon on 8/9 July 2012

    Science.gov (United States)

    Hecht, J. H.; Fritts, D. C.; Wang, L.; Gelinas, L. J.; Rudy, R. J.; Walterscheid, R. L.; Taylor, M. J.; Pautet, P. D.; Smith, S.; Franke, S. J.

    2018-01-01

    Although mountain waves (MWs) are thought to be a ubiquitous feature of the wintertime southern Andes stratosphere, it was not known whether these waves propagated up to the mesopause region until Smith et al. (2009) confirmed their presence via airglow observations. The new Andes Lidar Observatory at Cerro Pachon in Chile provided the opportunity for a further study of these waves. Since MWs have near-zero phase speed, and zero wind lines often occur in the winter upper mesosphere (80 to 100 km altitude) region due to the reversal of the zonal mean and tidal wind, MW breakdown may routinely occur at these altitudes. Here we report on very high spatial/temporal resolution observations of the initiation of MW breakdown in the mesopause region. Because the waves are nearly stationary, the breakdown process was observed over several hours; a much longer interval than has previously been observed for any gravity wave breakdown. During the breakdown process observations were made of initial horseshoe-shaped vortices, leading to successive vortex rings, as is also commonly seen in Direct Numerical Simulations (DNS) of idealized and multiscale gravity wave breaking. Kelvin-Helmholtz instability (KHI) structures were also observed to form. Comparing the structure of observed KHI with the results of existing DNS allowed an estimate of the turbulent kinematic viscosity. This viscosity was found to be around 25 m2/s, a value larger than the nominal viscosity that is used in models.

  12. Kongress Die Zukunft des Menschen : Dokumentation ; 10 Jahre Akademie für Technikfolgenabschätzung ; 8./9. Juli 2002, Stuttgart

    OpenAIRE

    2003-01-01

    Die Lebenswissenschaften haben einen Forschungsstand erreicht, der es ihnen erstmals erlaubt, an den Grundfesten des Menschseins zu rühren. Erwartungshaltung und Wirklichkeit klaffen jedoch weit auseinander. Zudem ist es oft schwierig, das Machbare von der Fiktion zu unterscheiden, angesichts der häufig emotional geführten Diskussion und dem ungehemmten Drang zur Selbstdarstellung bei manchen Beteiligten. Die „Durchbrüche“ auf diesem Gebiet sind außerdem noch wenig belastbar, wie man an dem f...

  13. The effect of auditory perception training on reading performance of the 8-9-year old female students with dyslexia: A preliminary study

    Directory of Open Access Journals (Sweden)

    Nafiseh Vatandoost

    2014-01-01

    Full Text Available Background and Aim: Dyslexia is the most common learning disability. One of the main factors have role in this disability is auditory perception imperfection that cause a lot of problems in education. We aimed to study the effect of auditory perception training on reading performance of female students with dyslexia at the third grade of elementary school.Methods: Thirty-eight female students at the third grade of elementary schools of Khomeinishahr City, Iran, were selected by multistage cluster random sampling of them, 20 students which were diagnosed dyslexic by Reading test and Wechsler test, devided randomly to two equal groups of experimental and control. For experimental group, during ten 45-minute sessions, auditory perception training were conducted, but no intervention was done for control group. An participants were re-assessed by Reading test after the intervention (pre- and post- test method. Data were analyed by covariance test.Results: The effect of auditory perception training on reading performance (81% was significant (p<0.0001 for all subtests execpt the separate compound word test.Conclusion: Findings of our study confirm the hypothesis that auditory perception training effects on students' functional reading. So, auditory perception training seems to be necessary for the students with dyslexia.

  14. Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS) versions 8, 9 and 10.1

    OpenAIRE

    Orchard, John; Rae, Katherine; Brooks, John; H?gglund, Martin; Til, Lluis; Wales, David; Wood, Tim

    2010-01-01

    John Orchard1, Katherine Rae1, John Brooks2, Martin Hägglund3, Lluis Til4, David Wales5, Tim Wood61Sports Medicine at Sydney University, Sydney NSW Australia; 2Rugby Football Union, Twickenham, England, UK; 3Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; 4FC Barcelona, Barcelona, Catalonia, Spain; 5Arsenal FC, Highbury, England, UK; 6Tennis Australia, Melbourne, Vic, AustraliaAbstract: The Orchard Sports Injury Classification Sys...

  15. Partial monosomy 8q and partial trisomy 9q due to the maternal translocation t(8;9(q24.3;q34.1)

    DEFF Research Database (Denmark)

    Tos, T; Alp, M Y; Eker, H K

    2014-01-01

    Partial trisomy 9q34-qter and partial monosomy 8q24.3-qter are very rare chromosomal abnormalities. Characteristic features of partial trisomy 9q34-qter are hypotonia, developmental delay, mild intellectual disability, dolichocephaly, distinct facial phenotype, long and thin fingers, and cardiac...

  16. Engine Response to Distorted Inflow Conditions: Conference Proceedings of the Propulsion and Energetics Specialists’ Meeting (68th) Held in Munich, Germany on 8-9 September 1986.

    Science.gov (United States)

    1987-03-01

    Heisenbergweg 39,8014 Neubiberg, Germany PANEL EXECUTIVE Dr E. Riester AGARD-NATO 7 rue Ancelle 92200 Neuilly sur Seine France ACKNOWLEDGEMENT The...this paper and to Rolls-Royce for permission to present it. The work has been carried out with the support of the Procurement Executive , Ministry of...Pourriez vous presenter ce papier a nouveau dans la partie -B" de cette reunion de specialistes ou de nombreux chercheurs en "ondes de choc " seront

  17. Energy Transitions in U.S. History, Grades 8-9. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy.

    Science.gov (United States)

    Brown, Evelyn; And Others

    This unit is intended to give students an understanding of the influence that various sources of energy have had on culture and on understanding of the effects of energy change. Physical properties of wood, coal, and oil are examined, and the ability of these substances to give heat is considered. Students practice the mathematics necessary to…

  18. An Energy History of the United States. Grades 8-9. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy.

    Science.gov (United States)

    National Science Teachers Association, Washington, DC.

    This instructional unit contains eight classroom lessons dealing with a history of energy in the United States for use in grade eight and nine social studies, science, and mathematics courses. The lessons were developed by teachers. The overall objective is to help students understand the present necessity to reexamine and perhaps alter our…

  19. NASA diagonal-braked test vehicle evaluation of traction characteristics of grooved and ungrooved runway surfaces at Miami International Airport, Miami, Florida, 8-9 May 1973

    Science.gov (United States)

    Horne, W. B.

    1977-01-01

    Two runways were evaluated under artificially wetted conditions with the NASA diagonal-braked vehicle (DBV). Results of the evaluation which included a pavement drainage analysis, a pavement skid resistance analysis, and a DBV wet/dry stopping distance ratio analysis indicated that the ungrooved runway surfaces had poor water drainage characteristics and poor skid resistance under wet conditions at high speeds especially in rubbercoated areas of the runways. Grooving runways to a transverse 1-1/4 x 1/4 x 1/4 inch pattern greatly improved both the water drainage and pavement skid resistance capability of these asphaltic concrete surfaces.

  20. Proceedings of the Cooling, Condensation, and Storage of Hydrogen Cluster Ions Workshop Held in Menlo Park, California on 8-9 January 1987.

    Science.gov (United States)

    1987-12-01

    5. Low susceptibility to accidental annihilation: Because large .4 cluster ions can be dynamically stored and have relatively small physical...1985. 10. Echt 0., Casero R., and Soler J. M., private communication. 7 0 p 0 N’. ’A. "--V ~N A f’~w N’.? .~ N’. ~b0aN N~ Robert L. Forward Prospects

  1. Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS versions 8, 9 and 10.1

    Directory of Open Access Journals (Sweden)

    John Orchard

    2010-10-01

    Full Text Available John Orchard1, Katherine Rae1, John Brooks2, Martin Hägglund3, Lluis Til4, David Wales5, Tim Wood61Sports Medicine at Sydney University, Sydney NSW Australia; 2Rugby Football Union, Twickenham, England, UK; 3Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; 4FC Barcelona, Barcelona, Catalonia, Spain; 5Arsenal FC, Highbury, England, UK; 6Tennis Australia, Melbourne, Vic, AustraliaAbstract: The Orchard Sports Injury Classification System (OSICS is one of the world’s most commonly used systems for coding injury diagnoses in sports injury surveillance systems. Its major strengths are that it has wide usage, has codes specific to sports medicine and that it is free to use. Literature searches and stakeholder consultations were made to assess the uptake of OSICS and to develop new versions. OSICS was commonly used in the sports of football (soccer, Australian football, rugby union, cricket and tennis. It is referenced in international papers in three sports and used in four commercially available computerised injury management systems. Suggested injury categories for the major sports are presented. New versions OSICS 9 (three digit codes and OSICS 10.1 (four digit codes are presented. OSICS is a potentially helpful component of a comprehensive sports injury surveillance system, but many other components are required. Choices made in developing these components should ideally be agreed upon by groups of researchers in consensus statements.Keywords: sports injury classification, epidemiology, surveillance, coding

  2. Electro-Organic Synthesis Of 2-Amino-9(4-Chlorophenyl)-5,7,8,9- Tetra Hydro-6H Benzo [7] Annulen-6-One in Acidic Medium

    OpenAIRE

    HEMLATA SHARMA; K.K JHANKAL; D.K. SHARMA

    2011-01-01

    The electro reduction of 5-(2-chlorophenyl)-1, 3- dihydro-7-2H-1, 4-benzodiazepin-2-one (clonazepam) has been studied by cyclic voltammetry at glassy carbon electrodes under the acidic conditions which indicate the reducible behavior of the drug. Electro-reduction of clonazepam has also been studied by the Galvanstatic technique at copper and amalgamated forms of copper and lead electrodes under acidic conditions. The reduction product was isolated and characterized by TLC, usual laboratory q...

  3. Unleashing the potentials of industrial energy productivity: Presentation held at Energy Efficiency Global Forum, May 8-9, 2017, Washington, D.C.

    OpenAIRE

    Sauer, Alexander

    2017-01-01

    The presentation "Unleashing the Potentials of Industrial Energy Productivity" deals with the following aspects: - Energy price and production in Germany 05/2015–05/2017 - Regenerative Energy supply across the world 2010 and plans for 2050 - Kopernikus Projects for the energy transition in Germnay

  4. Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS) versions 8, 9 and 10.1

    Science.gov (United States)

    Orchard, John; Rae, Katherine; Brooks, John; Hägglund, Martin; Til, Lluis; Wales, David; Wood, Tim

    2010-01-01

    The Orchard Sports Injury Classification System (OSICS) is one of the world’s most commonly used systems for coding injury diagnoses in sports injury surveillance systems. Its major strengths are that it has wide usage, has codes specific to sports medicine and that it is free to use. Literature searches and stakeholder consultations were made to assess the uptake of OSICS and to develop new versions. OSICS was commonly used in the sports of football (soccer), Australian football, rugby union, cricket and tennis. It is referenced in international papers in three sports and used in four commercially available computerised injury management systems. Suggested injury categories for the major sports are presented. New versions OSICS 9 (three digit codes) and OSICS 10.1 (four digit codes) are presented. OSICS is a potentially helpful component of a comprehensive sports injury surveillance system, but many other components are required. Choices made in developing these components should ideally be agreed upon by groups of researchers in consensus statements. PMID:24198559

  5. Continuing Education and Training and the Labour Market. Synthesis Report on a Conference Organized by CEDEFOP (Berlin, West Germany, March 8-9, 1984).

    Science.gov (United States)

    Hege, Adelheid

    This synthesis report summarizes a conference organized to examine the current situation regarding the continuing education and training of adults in the European Community and to formulate proposals for action. Some 60 conference participants examined various research reports, conducted discussions, and presented papers on three major topics:…

  6. The association of birth weight and infant growth with physical fitness at 8-9 years of age--the ABCD study

    NARCIS (Netherlands)

    van Deutekom, A. W.; Chinapaw, M. J. M.; Vrijkotte, T. G. M.; Gemke, R. J. B. J.

    2015-01-01

    Low birth weight and accelerated infant growth are independently associated with childhood obesity. We hypothesized that birth weight and infant growth are associated with physical fitness in childhood, and thereby could act as a link in the developmental origins of obesity. In addition, we assessed

  7. 0)1325476# 8#)9A @ B(C7C7D EF#GI HQP5 RSUTWV(XY`a ...

    Indian Academy of Sciences (India)

    2009-03-14 http://www.loksatta.com/daily/20090314/ch05.htm. #1. Leading International Marathi News Daily. Expressindia | T he Indian Express|The Financial Express| City Newslines | Screen | Kashmir Live ||. Express Computer. | Network Mag az ine Indja eBusiness TravelleExpressP harmal Express Hospitality| Express ...

  8. An International Dialogue on Community Colleges in a Changing World. [Symposium Report of] New Orleans Jam Session (New Orleans, Louisiana, January 8-9, 2002).

    Science.gov (United States)

    Rosenfeld, Stuart; Liston, Cynthia

    This document details a symposium that brought together U.S., Canadian, and European experts, college leaders, and policy makers for an "International Dialogue on Community Colleges in a Changing World." Discussion centered on the following four topics: (1) Community colleges are the largest source of postsecondary education for…

  9. Structural dualism in the zwitterionic 7-RR ' NH-nido-7,8,9-C3B8H10 tricarbollide series: An example of absolute tautomerism

    Czech Academy of Sciences Publication Activity Database

    Bakardjiev, Mario; Holub, Josef; Hnyk, Drahomír; Císařová, I.; Londesborough, Michael Geoffrey Stephen; Perelakin, D.S.; Štíbr, Bohumil

    2005-01-01

    Roč. 44, č. 38 (2005), s. 6222-6226 ISSN 1433-7851 R&D Projects: GA MŠk(CZ) LC523; GA ČR GA203/05/2646 Institutional research plan: CEZ:AV0Z40320502 Keywords : boron * carboranes * structural dualism Subject RIV: CA - Inorganic Chemistry Impact factor: 9.596, year: 2005

  10. Competitive Dairy Value Chains in Southeast Asia – Part II : Dairy Expert Roundtable Meeting, December 8 & 9, 2010, Muak Lek, Thailand

    NARCIS (Netherlands)

    Haartsen, L.; Lee, van der J.; Wouters, A.P.

    2011-01-01

    The regional Dairy Expert Roundtable Meeting on “Competitive Dairy Value Chains in Southeast Asia” provided a forum for participants from six Southeast Asian countries to discuss how dairy value chains in this region can become more competitive and sustainable. The demand for dairy products in these

  11. An unexpected rearrangement of carbon vertexes in the tricarbollide series. Asymmetrical 7-aryl-nido-7,8,9-C3B8H11 derivatives

    Czech Academy of Sciences Publication Activity Database

    Bakardjiev, Mario; Holub, Josef; Hnyk, Drahomír; Štíbr, Bohumil; Růžičková, Z.; Růžička, A.

    2016-01-01

    Roč. 805, MAR (2016), s. 117-121 ISSN 0022-328X R&D Projects: GA ČR(CZ) GAP207/11/0705 Institutional support: RVO:61388980 Keywords : Boron hydrides * Carboranes * NMR spectroscopy Subject RIV: CA - Inorganic Chemistry Impact factor: 2.184, year: 2016

  12. Open-face alkylation of the 8-R-nido-7,8,9-C3B8H11 tricarbollides

    Czech Academy of Sciences Publication Activity Database

    Bakardjiev, Mario; Holub, Josef; Tok, Oleg L.; Štíbr, Bohumil; Hnyk, Drahomír; Nekvinda, Jan; Růžičková, Z.; Růžička, A.

    2016-01-01

    Roč. 822, NOV (2016), s. 80-84 ISSN 0022-328X R&D Projects: GA ČR(CZ) GA16-01618S Institutional support: RVO:61388980 Keywords : Alkylation * Carboranes * NMR spectroscopy Subject RIV: CA - Inorganic Chemistry Impact factor: 2.184, year: 2016

  13. WHO informal consultation on quality, safety and efficacy specifications for live attenuated rotavirus vaccines Mexico City, Mexico, 8-9 February 2005.

    Science.gov (United States)

    Wood, David

    2005-12-01

    Rotavirus vaccines are at an advanced stage of development but there are as yet no WHO recommendations on production and quality control to provide regulatory guidance. A meeting of experts was convened by WHO and PAHO/AMRO to review the scientific basis for production and quality control of rotavirus vaccines, and to discuss specific measures to assure the safety and efficacy of rotavirus vaccines. The meeting was attended by 25 experts from 14 countries, drawn from academia, public health, national regulatory authorities and vaccine producers. It was agreed that existing guidance for other live virus vaccines provides a very good basis for product characterization, especially for source materials and control of production. The basis for attenuation of current vaccines or vaccine candidates is not known but, at least for the vaccines based on the Jennerian approach of using animal (bovine) rotaviruses, is likely to be multigenic. The risk of intussusception in humans is influenced by genetic background and age. Recent analyzes of large vaccine safety trials found that certain strains of vaccine virus were not associated with intussusception, although in these trials the first dose of vaccine was not administered to children over 3 months of age. Since age is a risk factor for intussusception, this may suggest that early delivery of the first dose of vaccine is desirable. However, maternal antibodies may mitigate against early delivery of the first vaccine dose. Factors which could affect vaccine efficacy or safety include strain diversity, malnutrition, other enteric infections, parasitic infection or immune suppression. It was concluded that data from clinical trials conducted in one part of the world would not necessarily be predictive of vaccine efficacy in other places. It was agreed that in nonclinical evaluations there was a need to use oral dosing for toxicity studies and, because rotavirus is non-neurovirulent, that there was no need for an animal neurovirulence test. For clinical evaluations there was a need for a standard definition of severe disease as the clinical endpoint, a need for studies in diverse geographical regions, and the need to control for possible interference by factors such as other oral vaccinations, intercurrent infections and breast feeding. There is no accepted correlate of protection. Secretory IgA is the most satisfactory laboratory parameter currently available and for a period after vaccination much of the specific serum IgA is of this type, so that serum IgA levels can act as measure of seroconversion. The need for standardization of the potency assay for release of vaccine was identified, as was a need to develop guidance on standardized approaches to post-marketing surveillance for rotavirus vaccines.

  14. Afican Health Sciences Vol 9 No 3.pmd

    African Journals Online (AJOL)

    Administrator

    Predictors which were highly associated with smoking initiation were previous ... Key words: Epidemiology, smoking initiation, adolescent, follow- up study. African Health Sciences ... teenagers remains high without any sign of decrease8,9,10.

  15. Relationships as determinants of substance use amongst street ...

    African Journals Online (AJOL)

    stress, peer relationships and frequency of family meals.7,8,9,10 Amongst ... students with the fewest peer interaction problems.12 Furthermore, the ..... substance use among street children in a local government area of Nigeria: Drug and.

  16. A survey of risk behaviour for contracting HIV among adult ...

    African Journals Online (AJOL)

    and sex workers, for example) and substance abuse.2,5,8,9,10. A survey ... Objective: Various studies have reported increased prevalence of HIV infection among psychiatric patients. ... The study took the form of a cross-sectional quantitative.

  17. Designing government: from instruments to governance

    National Research Council Canada - National Science Library

    Eliadis, F. Pearl; Hill, Margaret M; Howlett, Michael

    2005-01-01

    ... Selection and Implementation in a Networked Context 132 Hans Th.A. Bressers and Laurence J. O'Toole, Jr Choosing among Forms of Public Action: A Question of Legitimacy 154 Pierre Issalys 8 9 10 11 12 1...

  18. Exploration and exploitation of Antarctic krill resources

    Digital Repository Service at National Institute of Oceanography (India)

    Parulekar, A.H.; Matondkar, S.G.P.

    stream_size 5 stream_content_type text/plain stream_name World_Sci_News_1991_28(8,9-10)_31.pdf.txt stream_source_info World_Sci_News_1991_28(8,9-10)_31.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  19. Crystal structures of 2-benzylamino-4-(4-bromophenyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile and 2-benzylamino-4-(4-chlorophenyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile

    Directory of Open Access Journals (Sweden)

    R. A. Nagalakshmi

    2015-01-01

    Full Text Available In the title compounds, C24H22BrN3, (I, and C24H22ClN3, (II, the 2-aminopyridine ring is fused with a cycloheptane ring, which adopts a half-chair conformation. The planes of the phenyl and benzene rings are inclined to that of the central pyridine ring [r.m.s. deviations = 0.0083 (1 and 0.0093 (1 Å for (I and (II, respectively] by 62.47 (17 and 72.51 (14°, respectively, in (I, and by 71.44 (9 and 54.90 (8°, respectively, in (II. The planes of the aromatic rings are inclined to one another by 53.82 (17° in (I and by 58.04 (9° in (II. In the crystals of both (I and (II, pairs of N—H...Nnitrile hydrogen bonds link the molecules, forming inversion dimers with R22(12 ring motifs. In (I, the resulting dimers are connected through C—H...Br hydrogen bonds, forming sheets parallel to (10-1, and π–π interactions [inter-centroid distance = 3.7821 (16 Å] involving inversion-related pyridine rings, forming a three-dimensional network. In (II, the resulting dimers are connected through π–π interactions [inter-centroid distance = 3.771 (2 Å] involving inversion-related pyridine rings, forming a two-dimensional network lying parallel to (001.

  20. Evaluation and review of planning for greater-confinement disposal by the Independent Peer Review Committee, July 9-10, 1985. Final report

    International Nuclear Information System (INIS)

    1985-07-01

    This evaluation and review was performed under contract by Argonne National Laboratory in support of their role for developing the ''Planning for Greater Confinement Disposal'' Document for the Low-Level Waste Management Program Office for the Department of Energy, Office of Defense Waste and Byproducts Management. The Independent Peer Review Committee was composed of 13 well-qualified and recognized experts in their fields and pertinent disciplines, collectively representing considerable expertise and experience in waste disposal operations, waste management, environmental assessment and impact analysis, and other aspects of radioactive waste disposal. The members of the Peer Review Committee, their organizations, and thier area of expertise are given in Appendix 1. The general consensus of the Independent Review Committee was that the ''Planning for Greater-Confinement Disposal'' document was reasonably comprehensive, covering nearly all topics necessary to provide a good planning guide. There is, however, a definite need to reorganize the document into two volumes with appendices and the relationship of the GCD document to other LLWMP documents needs to be clarified in the introductory volume. Specific recommendations made by the committee on the DCD document are given in Section 3.2. Recommendations by the committee that have a somewhat broader scope than just the GCD document are given in Section 3.3

  1. Minutes of the Explosives Safety Seminar (19th) Held at Los Angeles, California on 9-10-11 September 1980. Volume II

    Science.gov (United States)

    1980-09-01

    Ferrite formulation. After a series of laboratory tests, it was determined that the standard ferrite formulation MN-67 had the best trade -off of low...of subsurface ordnance items should be intergrated into a complete system. The fielded AN/PsS-l1 metal detector and the recently approved MK 22

  2. Relevance of 1,2,5,6,9,10-hexabromocyclododecane diastereomer structure on partitioning properties, column-retention and clean-up procedures.

    Science.gov (United States)

    Mariussen, Espen; Haukås, Marianne; Arp, Hans Peter H; Goss, Kai-Uwe; Borgen, Anders; Sandanger, Torkjel M

    2010-02-26

    To optimize clean-up procedures for the analysis of alpha-, beta-, and gamma-hexabromocyclododecanes (HBCD) in environmental and biological extracts, their retention behavior on silica gel and florisil was investigated using diverse mobile-phase solvents and accounting for matrix effects. The beta-diastereomer, relative to the alpha- and gamma-diastereomers, is substantially retained on both florisil and silica gel regardless of the solvent used. The beta-diastereomer is therefore prone to undergo selective loss during clean-up. This sequence is counterintuitive to sequences based on reverse-phase chromatography with a C18-column, in which the alpha- (and not the beta-) isomer is eluted first when using a polar solvent. There has been some discrepancy regarding the structures of these diastereomers in the literature, with structures based on X-ray crystallography only becoming recently available. Based on these X-ray crystal structures, physical-chemical properties (the octanol-water partitioning constant, the Henry's law constant, subcooled liquid vapour pressures and subcooled liquid water solubilities) of the HBCD diastereomers were estimated using the quantum-chemistry based software COSMOtherm, and were found to differ from previously calculated values using different structures (e.g. log K(aw) for alpha-, beta-, and gamma-HBCD are here estimated to be -8.3, -9.3 and -8.2 respectively). Hypothesis relating differences in structure to physical-chemical properties and retention sequences are presented. The extra retention of the beta-diastereomer on silica gel and florisil is likely because it can form both greater specific (i.e. polar) and non-specific (i.e. non-polar) interactions with surfaces than the other diastereomers. Non-specific interactions can also account for the counter-intuitive elution orders with C(18)-reverse-phase chromatography. These results indicate that care should be taken when isolating HBCDs and other molecular diastereomers from environmental and biological samples, and that reported concentrations of beta-HBCD in the literature may be negatively biased. Copyright 2010 Elsevier B.V. All rights reserved.

  3. A Common Genetic Factor Explains the Covariation among ADHD ODD and CD Symptoms in 9-10 Year Old Boys and Girls

    Science.gov (United States)

    Tuvblad, Catherine; Zheng, Mo; Raine, Adrian; Baker, Laura A.

    2009-01-01

    Previous studies examining the covariation among Attention Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) have yielded inconsistent results. Some studies have concluded that the covariation among these symptoms is due to common genetic influences, whereas others have found a common…

  4. Quinoidal Oligo(9,10-anthryl)s with Chain-Length-Dependent Ground States: A Balance between Aromatic Stabilization and Steric Strain Release

    KAUST Repository

    Lim, Zhenglong; Zheng, Bin; Huang, Kuo-Wei; Liu, Ye; Wu, Jishan

    2015-01-01

    : the large steric repulsion between the anthryl/phenyl units in the closed-shell quinoidal form that drives the molecule to a flexible open-shell diradical structure, and aromatic stabilisation due to the gain of more aromatic sextet rings in the closed

  5. 7-Hydroxy-8-isopropyl-1,1,4a-trimethyl-4a,9,10,10a-tetrahydro-phenanthren-2(1H-one

    Directory of Open Access Journals (Sweden)

    Ahmed Benharref

    2011-04-01

    Full Text Available The title compound, C20H26O2, was isolated from a chloroform extract of Tetraclinis articulata wood. The molecule contains three fused rings which exhibit different conformations. The non-aromatic oxo-substituted ring has a screw-boat conformation, while the central ring has a half-chair conformation. In the crystal, molecules are linked to each other by intermolecular O—H...O hydrogen bonds involving the carbonyl and hydroxy groups.

  6. 8a-Methyl-5,6,8,8a,9,10-hexahydro-10,12a-epoxyisoindolo[1,2-a]isoquinolinium iodide

    Directory of Open Access Journals (Sweden)

    Flavien A. A. Toze

    2010-06-01

    Full Text Available The title compound, C17H18NO+·I−, is an adduct resulting from an intramolecular Diels–Alder reaction of methallyl chloride with 3,4-dihydro-1-furylisoquinoline. The cation comprises a fused pentacyclic system containing three five-membered rings (dihydropyrrole, dihydrofuran and tetrahydrofuran and two six-membered rings (tetrahydropyridine and benzene. The five-membered rings have the usual envelope conformations, and the central six-membered tetrahydropyridine ring adopts the unsymmetrical half-boat conformation. In the crystal, cations and iodide anions are bound by weak intermolecular hydrogen-bonding interactions into a three-dimensional framework.

  7. HTR-PROTEUS pebble bed experimental program cores 9 & 10: columnar hexagonal point-on-point packing with a 1:1 moderator-to-fuel pebble ratio

    Energy Technology Data Exchange (ETDEWEB)

    Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-03-01

    PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

  8. Excited-state intramolecular hydrogen transfer (ESIHT) of 1,8-Dihydroxy-9,10-anthraquinone (DHAQ) characterized by ultrafast electronic and vibrational spectroscopy and computational modeling

    KAUST Repository

    Mohammed, Omar F.; Xiao, Dequan; Batista, Victor S.; Nibbering, Erik Theodorus Johannes

    2014-01-01

    of femtosecond UV/vis and UV/IR pump-probe spectroscopic data. Upon photoabsorption at 400 nm, the S 2 electronic excited state is initially populated, followed by a rapid equilibration within 150 fs through population transfer to the S 1 state where DHAQ

  9. Methods of estimating the state of the mechanisms of regulation of cardiac activity for girls 9-10 years of age during physical training aimed at developing endurance

    Directory of Open Access Journals (Sweden)

    Samokih I.I.

    2012-02-01

    Full Text Available Are considered indicators of regulation of cardiac activity proposed D.N. Davidenko et al. (1984. It is established age-related indicators in girls from 9 to 10 years. It is shown that in the process of double-entry physical training with the implementation of priority endurance exercise significantly improves the efficiency of regulation of cardiac activity for girls. The expediency of the lessons of physical culture directed on the priority of development endurance to improve the physical health of school girls of primary school.

  10. THE EXAMINATION OF THE EFFECTS OF THE RHYTHMIC TEACHING OF PHYSICAL EDUCATION ON SPEED OF 9-10 YEARS OLD GIRLS

    Directory of Open Access Journals (Sweden)

    Dragana Aleksić

    2013-07-01

    Full Text Available By different moving activities, learning about their body and its mothoric, a child develops its mothoric, acquires different motoric skills and habits and develops motoric activities. In this work, the subject of the research is just one segment of the anthropological area which refers to the appearance of appropriate motor abilities-speed. The research involved a total sample of 99 girls from the 3th and 4th grade of elementary school. The subjects were classified in experimental and control groups. The experimental group was made of 51 students and they were practicing according to planning instruction where the rhythmic gymnastics had the primary part. The control group of 48 students was practicing according to official instructional plan and program for P.E. of the Republic of Serbia. At the beginning of the academic year, initial (first measurement was performed, followed by experimental final (second measurement at the end of experiment. Research data was processed using SPSS standard statistics procedure. The multi-variant procedures were used in this research ant those were: the multi-variant analysis of the variable MANCOVA i MANOVA. Also, the mono-variant procedures were used and those were: the variable analysis ANCOVA, ANOVA and the interval of entrust. Considering the difference of the influence of the treatment, it can be pointed out that the experimental program, with all its characteristics, widely contributed to all its segments to the improvement of speed. It is known that the use of physical exercise stimulation only within regular physical education classes is not sufficient to provoke essential improvement of motoric abilities. Therefore it is very important not only to try to animate schoolboys for participation in additional sporting activities, especial rhythmic gymnastics, out of regular physical education classes, but, what is even more important, to increase the number of physical education classes a week, with the ambition to provide sufficient stimulation to ensure a harmonic somatic growth and development.

  11. Intellectual Freedom and the National Laboratories : 2000 Sigma Xi Forum New Ethical Challenges in Science and Technology, November 9-10, 2000, Albuquerque, New Mexico"

    Energy Technology Data Exchange (ETDEWEB)

    Browne, John C.

    2001-01-01

    As we move toward the 21st century, I believe the importance of the ethical system on which the scientific establishment, including the national laboratories, can build its contributions to society is becoming increasingly more important. Issues include the impact of the research we do, the trust we have between ourselves and the general public and the federal government, and the complexity of the problems that we work on. One of the most important roles that I see for research management in large institutions, like the national laboratories, is to create the appropriate environment for ethical behavior for all of its employees. Ethics and modern science demands that we create and live a set of shared values. As Bob Dynes pointed out this morning, we're not just talking about rules. We really must have values upon which we build and create the kind of behaviors we want to see. The major issue that I see in developing these shared values is that management and employees must jointly develop, socialize and live those shared values. In this session today, as I said, we want to explore the issues of intellectual freedom and ethical environment in government and the contracts under which the national laboratories operate. One of the laboratories is run by a nonprofit, the University of California, and the other is a paid-for-profit corporation. I don't know if there are any differences, depending on who the overseeing contractor is. I don't think there are, but it would be interesting to explore any differences we might see between the two. We have chosen the title 'Intellectual Freedom.' It's not academic freedom. Although, clearly, there are a lot of shared attributes between academic freedom and intellectual freedom. In our case, intellectual freedom allows our researchers to challenge technical decisions that are made by the laboratory, by the government or by their peers in their area of expertise, not in policy making, but in the scientific realm. It really does not permit them the freedom to roam at will outside of their areas of technical expertise into the realm of policy without clearly stating that their remarks are those of a private citizen and must be handled, therefore, outside of the laboratory business. This is a major issue within our laboratories, and I think one that we try to nurture very carefully, because without it, we think that there would be a closing up of laboratories because of the type of classified work that we do. The issues that I hope we might explore in this session include, (1) how do you give technical advice to a policymaker? Where do you draw the line with respect to your judgment, your advice versus your opinion, which can change how government attacks very significant societal problems: (2) The issue of security and classification. How does that affect the intellectual freedom of our staff? (3) Dealing with the public on matters of risk. I am going to add to that, also, dealing with our employees on matters of risk, because one of the things that we're finding as we get better with our detection technology and our screening technologies, we now find out about how employees might be susceptible to illnesses, such as berylliosis, problems with beryllium sensitivity. What ethical issues arise when you now have the ability to learn more about impacts on, not only the public, but your employees as well? We share similar types of problems that Bob Dynes mentioned: conflict of interest, intellectual property questions. And we also have the conflict of interest as an institution. And I'll just mention one--perhaps it could come up in the discussion-is in the past year we had an issue with respect to how the Congress and the Administration handled the Comprehensive Test Ban Treaty. What kind of eihical issues arise in testing on our technical judgment regarding the CTBT versus institutional conflict of interest? Questions were raised. Were the laboratory directors simply protecting budgets or were they speaking out on technical matters in which they believe very strongly? So, I think we have many of these issues that come into play in our jobs every day. The security issues raised in the past year regarding Los Alamos were complicated, in my opinion, because of stories in the media that were not necessarily complete or accurate. They were also Complicated by the actions of the federal government in not allowing certain information to be made public because of ongoing litigation. So, it raised a lot of questions, and I think, in the next 5 to 10 years, the events of the past year or two will actually raise a lot of ethical questions about how people handle classified information, not just at the national laboratories, but in general. Not only the legal issues, but the ethical issues, the values associated with handling classified information.

  12. Proceedings of the Tripartite Conference on Submarine Medicine (3rd)-- France, United Kingdom, and United States, 9-10 May 1983

    Science.gov (United States)

    1983-06-01

    various stimuli. Without attempting to give any actual explanation of this we will compare such theoretical ikeas with the fact that during NEBALIA...degree of fatness, glyonsylated hemiglobin, or family history of diabetes. Highly significant differences in the mount of exercise were found between

  13. June 9-10, 2015: A case study of the Great Plains Low-Level Jet during PECAN (Plains Elevated Convection at Night)

    Science.gov (United States)

    Sullivan, Sharon M.

    Observations as part of the Plains Elevated Convection at Night (PECAN) campaign have allowed for an examination of the thermodynamic and dynamic structure of the LLJ using ground-based and airborne measurements in central Kansas. A shallow jet with wind speeds near 20 m s-1 formed during the nighttime hours on 10 June 2015. The University of Wyoming King Air research aircraft conducted two research flights beginning at sunset and ending near dawn, capturing the full evolution of the LLJ. Each flight included a series of vertical sawtooth maneuvers and isobaric legs along a fixed track at 38.7°N between 98.89°W and 100.3°W. This case featured classic signatures of the LLJ, including but not limited to the inertial oscillation of the ageostrophic wind. Forcing of the LLJ was analyzed using cross sections of D-values that allowed the vertical structure of the horizontal pressure gradient and hence thermal wind to be examined. A series of numerical simulations of the 10 June 2015 case study were made using the Weather Research and Forecasting (WRF) model to compare with observations. Output grids indicated that a temperature gradient of 6°C over 500 km was present between the surface and 850 hPa. Warmer temperatures were found to the west from the surface up to 600 hPa. The 600 hPa geostrophic winds were from the north. As a result, only weak southerly geostrophic winds were able to develop at the surface. The terrain-induced thermal wind was sufficiently large to overcome the adverse pressure gradient in the free atmosphere, but could only produce weak southerly geostrophic winds at the surface of about 11.4 m s-1.

  14. Fuel gas production from animal and agricultural residues and biomass. Seventh quarterly coordination meeting, Seattle, Washington, January 9--10, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Wise, D. L; Wentworth, R. L

    1978-01-27

    A regular coordination meeting, the seventh in a quarterly series, was held of the ''methane production'' group of the Fuels from Biomass Systems Branch, U.S. Department of Energy. The meeting was held in Seattle, Washington in order to site visit the Monroe, Washington anaerobic digester facility operated by Ecotope Group, Inc. In addition, progress reports were presented from all contractors. A list of attendees, the working schedule, and the progress reports and special topical reports presented are included in the following. Separate abstracts were prepared for the progress and special topical reports.

  15. Report on childhood obesity in China (5) Body weight, body dissatisfaction, and depression symptoms of Chinese children aged 9-10 years

    NARCIS (Netherlands)

    Li, Y.P.; Ma, G.S.; Schouten, E.G.; Hu, X.Q.; Cui, Z.H.; Wang, D.; Kok, F.J.

    2007-01-01

    To investigate the relationship between body weight, body dissatisfaction and depression symptoms among Chinese children. METHODS: The fasting body weight and height of the third and fourth grade students (n = 3886, aged 9 or 10 years) from 20 schools in Beijing, China, were measured, and the

  16. Energy in the Global Marketplace. Grades 9, 10, 11. Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy.

    Science.gov (United States)

    National Science Teachers Association, Washington, DC.

    This instructional unit contains six classroom lessons in which 9th, 10th, or 11th grade social studies students examine the effects of competition among nations and world regions as demand for oil outstrips supply. The overall objective is to help students understand the concept that energy is a commodity to be bought and sold like any other…

  17. Proceedings of The 13. Nordic Workshop on Secure IT Systems, NordSec 2008, Kongens Lyngby Oct 9-10, 2008

    DEFF Research Database (Denmark)

    in Security and Mobile Computing “NordSecMob”, and a meeting of the FIRST research school. We received a total of 39 submissions in response to the call for papers, and the programme committee selected 17 of these for presentation at the workshop—one short paper, which is not included in the proceedings......, and 16 research papers. It was a pleasure for us to work with the program committee, and we want to thank both them and the additional reviewers. Beside the submitted contributions we invited Audun Jøsang, University of Oslo, and Michael Huth, Imperial College London, to speak at the workshop. Abstracts...

  18. Generational Differences in Work Values between Parents and Children and between Boys and Girls across Grade Levels 6, 9, 10, and 12

    Science.gov (United States)

    Wijting, Jan P.; And Others

    1978-01-01

    Cross-sectional comparison of elementary and secondary school children and parents examined changes in work values and relationships between children's and parents' work values as a function of age and sex. Revealed support for hypothesized differences in children's values and for convergence of sex differences in values at later ages. (Author)

  19. HAER Level II Documentation of Launch Complexes 1/2, 3/4, 9/10, 14, and 34 at Cape Canaveral Air Force Station, Florida

    Science.gov (United States)

    2016-06-01

    construction on Complex 14 in March 1956. The initial construction costs for the “ brick and mortar ” totaled $4,308,000. Although the complex reached...initial construction costs for the “ brick and mortar ” totaled $6,215,000. By 1966, the complex was valued at $25,340,000. Although the complex reached...situated beneath the opening between the columns of the Pedestal. The portion of the pad around the deflector is surfaced with refractory brick to

  20. Mezinárodní konference o etnických menšinách. Praha 9.-10. února 2012

    Czech Academy of Sciences Publication Activity Database

    Valášková, Naďa; Weinerová, Renata

    2012-01-01

    Roč. 99, č. 1 (2012), s. 115-117 ISSN 0009-0794 Institutional support: RVO:68378076 Keywords : conference * minority ethnic groups * stereotypes * prejudices * conflicts Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.094, year: 2012

  1. Groundwater/porewater hydrochemistry at Horonobe URL. Data freeze 1. Preliminary data quality evaluation for boreholes HDB-9, 10 and 11

    International Nuclear Information System (INIS)

    Kunimaru, Takanori; Ota, Kunio; Alexander, W. Russell; Yamamoto, Hajime

    2010-11-01

    Characterisation of the geological environment within host sedimentary formations is currently ongoing at the site of the Horonobe Underground Research Laboratory in northern Hokkaido, Japan, with the main aim of establishing and testing the relevant techniques for future repository site characterisation. One facet of this is one of the first use of rock matrix porewater data in Japan, in conjunction with the site groundwater data, as part of characterisation of the site hydrochemistry. Surface-based investigations have been largely completed and one of the remaining issues is the development of an appropriate quality assurance (QA) system which is applicable to all aspects of the site characterisation process. A QA audit of hydrochemical datasets for boreholes HDB-9 - 11 has been carried out by the application of a formal QA analysis which is based on the methodology previously employed for groundwaters during the recent site characterisation programme in Sweden. To set this novel approach specifically for rock matrix porewater data in context, several guidelines for assigning the QA categories of the porewater data are proposed. Discussion on the quality level of both the groundwater and porewater data is presented as is a preliminary description of the site hydrochemistry. This exercise has indicated areas where additional information would be of value and further improvement of work would be required to the ongoing hydrochemical characterisation at Horonobe. Overall, it is emphasised that an appropriate QA system, which is among the first such tools required for repository site characterisation, will save on effort by reducing errors and the requirement to re-sample and re-analysis - but this can only be guaranteed by continuously assessing if the system is truly fit-for-purpose and amending it as necessary based on the practical experience of the end-users on-site. (author)

  2. (1S,3S,8R,9S,10R-9,10-Epoxy-3,7,7,10-tetramethyltricyclo[6.4.0.01,3]dodecane

    Directory of Open Access Journals (Sweden)

    Abdoullah Bimoussa

    2014-04-01

    Full Text Available The title compound, C16H26O, was synthesized by treating (1S,3S,8R-3,7,7,10-tetramethyltricyclo[6.4.0.01,3]dodec-9-ene with metachloroperbenzoic acid. The molecule is built up from two fused six- and seven-membered rings. The six-membered ring has a half-chair conformation, whereas the seven-membered ring displays a boat conformation. In the crystal, there are no significant intermolecular interactions present.

  3. HTR-PROTEUS PEBBLE BED EXPERIMENTAL PROGRAM CORES 9 & 10: COLUMNAR HEXAGONAL POINT-ON-POINT PACKING WITH A 1:1 MODERATOR-TO-FUEL PEBBLE RATIO

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess

    2013-03-01

    PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

  4. Synthesis and electrospinning carboxymethyl cellulose lithium (CMC-Li) modified 9,10-anthraquinone (AQ) high-rate lithium-ion battery.

    Science.gov (United States)

    Qiu, Lei; Shao, Ziqiang; Liu, Minglong; Wang, Jianquan; Li, Pengfa; Zhao, Ming

    2014-02-15

    New cellulose derivative CMC-Li was synthesized, and nanometer CMC-Li fiber was applied to lithium-ion battery and coated with AQ by electrospinning. Under the protection of inert gas, modified AQ/carbon nanofibers (CNF)/Li nanometer composite material was obtained by carbonization in 280 °C as lithium battery anode materials for the first time. The morphologies and structures performance of materials were characterized by using IR, (1)H NMR, SEM, CV and EIS, respectively. Specific capacity was increased from 197 to 226.4 mAhg(-1) after modification for the first discharge at the rate of 2C. Irreversible reduction reaction peaks of modified material appeared between 1.5 and 1.7 V and the lowest oxidation reduction peak of the difference were 0.42 V, the polarization was weaker. Performance of cell with CMC-Li with the high degree of substitution (DS) was superior to that with low DS. Cellulose materials were applied to lithium battery to improve battery performance by electrospinning. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Minutes of the Explosives Safety Seminar (19th) Held at Los Angeles, California, 9-10-11 September 1980. Volume 1

    Science.gov (United States)

    1980-01-01

    acid is the principal fuel. The coating is added to prevent the water-aluminum reaction. The guar gum is used as the thickening gelling agent to prevent...and the components did not stay mixed. The thickening characteristic was not present. A DTA/TGA thermogram of a guar gum sample dried for 18.5 days at...to 4.6 ± 0.1 POWDER COMPONENT Aluminum (coated wtth .125% isostearic acid) 97.6 ± 2.0Guar Gum 1.4 * 0.2Potassium Acid Phthalate 1.0 ± 0.2 679 IJ x x

  6. Diacetonitrile(3-{2-[8-(2-bromoethoxy-9,10-dioxoanthracen-1-yloxy]ethyl}-1-(2-pyridylmethylimidazoliumsilver(I bis(hexafluoridophosphate

    Directory of Open Access Journals (Sweden)

    Qing-Song Wen

    2010-08-01

    Full Text Available The title compound, [Ag(C27H23BrN3O4(CH3CN2](PF62, is a mononuclear salt species in which the silver(I atom is coordinated by one ligand and two acetonitrile molecules and exhibits a distorted T-shaped coordination. The asymmetric unit contains one independent cation and two independent hexafluoridophosphate anions, one of which is disordered over two positions in a 0.756 (11:0.244 (11 ratio. Weak π–π interactions between the anthraquinone ring systems [centroid–centroid distance = 3.676 (3 Å], intermolecular Ag–π interactions [Cg...Ag = 3.405 Å] and C—H...π interactions between pairs of adjacent molecules are observed.

  7. Founders' Weekend. North Country Workshop on Science, Technology and the Undergraduate Curriculum. Proceedings (Potsdam, New York, November 9-10, 1984).

    Science.gov (United States)

    State Univ. of New York, Potsdam. Coll. at Potsdam.

    Proceedings of the North Country Workshop on Science, Technology, and the Undergraduate Curriculum are presented. The Sloan Foundation's call for reform of the liberal arts and coverage of mathematics, science, and technology is noted in welcoming remarks by State University of New York, Potsdam, President Humphrey Tonkin. Stephen H. Cutcliffe…

  8. The Study of the Intramolecular Heavy Atom Effect in 9,10-Dichlorophenanthrene and 1,2,3,4-Tetrachloronaphthalene Using PMDR Techniques.

    Science.gov (United States)

    1978-06-30

    Inc . , 1974. 4. C. T. u n , Thesis , UCLA, 1974. 5. N. A. El-Sayed, Acta Phys. Polonica , XXXIV , 649(1968). 6. N. A. El-Sayed , Proceedings for the m...See Refs. 11 ,15 A. de Groot and 3. H. van der Waals, Physica 19, 1128 (1963). L

  9. Writing Our Way: Giving Voice to Adult Learning. Adult Higher Education Alliance Annual Conference Proceedings (41st, Orlando, Florida, March 9-10, 2017)

    Science.gov (United States)

    Elufiede, Kemi, Ed.; Flynn, Bonnie, Ed.; Olson, Joann S., Ed.

    2017-01-01

    The 41st annual conference of the Adult and Higher Education Alliance (AHEA) was held at the University of Central Florida in March 2017 and explored the theme, "Writing Our Way: Giving Voice to Adult Learning." Papers in these proceedings include: (1) Transformative Learning Following Job Loss-A Dissertation Renewal (Robert Benway); (2)…

  10. 1,5-Diamido-9,10-anthraquinone, a Centrosymmetric Redox-Active Bridge with Two Coupled β-Ketiminato Chelate Functions: Symmetric and Asymmetric Diruthenium Complexes

    Czech Academy of Sciences Publication Activity Database

    Ansari, M. A.; Mandal, A.; Paretzki, A.; Beyer, K.; Fiedler, Jan; Kaim, W.

    2016-01-01

    Roč. 55, č. 11 (2016), s. 5655-5670 ISSN 0020-1669 R&D Projects: GA MŠk LD14129 Institutional support: RVO:61388955 Keywords : MIXED-VALENCE COMPLEXES * RUTHENIUM COMPLEXES * ELECTRON-TRANSFER Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.857, year: 2016

  11. Effect of Vitamin D in HN9.10e Embryonic Hippocampal Cells and in Hippocampus from MPTP-Induced Parkinson’s Disease Mouse Model

    Directory of Open Access Journals (Sweden)

    Samuela Cataldi

    2018-02-01

    Full Text Available It has long been proven that neurogenesis continues in the adult brains of mammals in the dentatus gyrus of the hippocampus due to the presence of neural stem cells. Although a large number of studies have been carried out to highlight the localization of vitamin D receptor in hippocampus, the expression of vitamin D receptor in neurogenic dentatus gyrus of hippocampus in Parkinson’s disease (PD and the molecular mechanisms triggered by vitamin D underlying the production of differentiated neurons from embryonic cells remain unknown. Thus, we performed a preclinical in vivo study by inducing PD in mice with MPTP and showed a reduction of glial fibrillary acidic protein (GFAP and vitamin D receptor in the dentatus gyrus of hippocampus. Then, we performed an in vitro study by inducing embryonic hippocampal cell differentiation with vitamin D. Interestingly, vitamin D stimulates the expression of its receptor. Vitamin D receptor is a transcription factor that probably is responsible for the upregulation of microtubule associated protein 2 and neurofilament heavy polypeptide genes. The latter increases heavy neurofilament protein expression, essential for neurofilament growth. Notably N-cadherin, implicated in activity for dendritic outgrowth, is upregulated by vitamin D.

  12. Fosforiidisõda / Juhan Aare

    Index Scriptorium Estoniae

    Aare, Juhan, 1948-

    1999-01-01

    Järg Jan/5;6;7;8;9;11;12;13;14;15;16;18;19;20;21;22;23;25;26;27;28;29;30/Feb/1;2;3;4;5;6;8;9;10;11;12;13;15;16;17;18;19;20;22;23;25;26;27/Mar/1;2;3;4;5;6;8;9;10;11;12;13;15;16;17;18;20;22;23;24;25;26;27;29;30;31/Apr/1;2;35;6;7;8;9;10;12;13;14;15;16;17;19;20;21;22;23;24;26;27;28;29;30/May/3;4;5;6;7;8;10;11;12;13;14;15;17;18;19;20;21;22;24;25;26;27;28;29;31

  13. Ekspress suundus läände / Heimar Lenk

    Index Scriptorium Estoniae

    Lenk, Heimar, 1946-

    1998-01-01

    Järg Jun/9,10,11,12,13;14;15;16;17;18;19;20;21;22;26;27;29:30; Jul/1;2;3;4;6;7;8;9;10;11;13:14;15;16:17;18;20;21;22;23;24;25;27;28;29;30;31; Aug/3;4;5;6;7;8;10;11;12;13;14;17;18;19;21;22;24;25;26;27;29;31; Sep/1;2;3;4;5;7;8;9;10;11;12;14;15;16;17;18;19;21;22;23;24;25;26;28;29;30, Oct/1;2;3;5;6;7;8;9;10

  14. Stereo-selectivity and regio-selectivity in the metabolism of 7,8-dihydrobenzo[a]pyrene by cytochrome P450, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats.

    Science.gov (United States)

    Adams, J D; Yagi, H; Levin, W; Jerina, D M

    1995-03-30

    The active site of cytochrome P450 1A1 has been probed with the substrate 7,8-dihydrobenzo[a]pyrene using a purified, reconstituted system composed of cytochrome P450 1A1, NADPH-cytochrome c reductase and lipid in the presence or absence of epoxide hydrolase. The turnover of the substrate was found to be 38 nmol/nmol of cytochrome P450/min. The metabolic products that were identified are: a phenolic 7,8-dihydrobenzo[a]pyrene (20-29%); 9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (17-28%); benzo[a]pyrene (12-19%); 7-hydroxy-7,8-dihydrobenzo[a]pyrene (13-16%); 8-hydroxy-7,8-dihydrobenzo[a]pyrene (7-15%); 3-hydroxybenzo[a]pyrene (7-15%); 4,5-epoxy-4,5,7,8-tetrahydrobenzo[a]pyrene (0-4%); and a triol of 7,8,9,10-tetrahydrobenzo[a]pyrene (0-4%). 9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene undergoes rapid hydrolysis to cis- and trans-9,10-dihydroxy-dihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (2:1) by benzylic attack of water at C-10. Approximately 71% of the trans diols are derived from (+)-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, indicating that cytochrome P450 1A1 has more than a 2:1 preference for selective epoxidation of an enantiotopic face of 7,8-dihydrobenzo[a]pyrene. This stereo-selectivity agrees with the postulated stereo-selectivity predicted by a previously described active site model for cytochrome P450 1A1. Epoxide hydrolase in pure form or in hepatic microsomes catalyzes the hydrolysis of 9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, which is inhibited by 1,1,1-trichloropropane 2,3-oxide. The (+)-(9S,10R)-isomer of the epoxide is slightly preferred as a substrate over its enantiomer and is cleaved by benzylic and nonbenzylic attack. Only benzylic attack was found with (-)-(9R,10S)-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

  15. Coste-efectividad de un programa de actividad física de tiempo libre para prevenir el sobrepeso y la obesidad en niños de 9-10 años Cost-effectiveness of an intervention to reduce overweight and obesity in 9-10-year-olds. The Cuenca study

    Directory of Open Access Journals (Sweden)

    Pablo Moya Martínez

    2011-06-01

    Full Text Available Objetivos: Analizar el coste-efectividad de una intervención de actividad física de tiempo libre diseñada para reducir el sobrepeso, la obesidad y otros factores de riesgo cardiovascular en escolares. Métodos: Se realiza un análisis de coste-efectividad desde la perspectiva social e institucional de un ensayo de campo aleatorizado por cluster en 10 colegios de intervención (691 niños y 10 de control (718 niños. Se calculan los costes netos como la diferencia entre los costes del programa y las posibles alternativas. La efectividad se mide como la reducción en las medidas de salud frente al grupo de control. Resultados: El coste total de la intervención se estima en 125.469,75€, 269,83€ por año y niño. Los escolares del grupo de intervención mostraron un descenso del grosor del pliegue cutáneo tricipital (-1,25mm; intervalo de confianza del 95% [IC95%]: -1,82 a -0,67; pP75. Conclusiones: Realizar programas de actividad física como la intervención objeto de estudio es una forma coste-efectiva de prevenir la obesidad y de hacer un uso rentable de los fondos públicos.Objective: To assess the cost-effectiveness a school-based intervention designed to reduce overweight/obesity and other cardiovascular risk factors in children. Methods: Standard cost effectiveness analysis methods and two perspectives (societal and institutional were used. A cluster-randomized controlled trial with 10 intervention schools (691 children and 10 control schools (718 children was performed. Net costs were calculated by subtracting the usual after-school care cost from intervention costs. The effectiveness of the intervention was measured as the reduction in health outcomes compared with the control group. Results: The intervention costs totaled 125,469.75€, representing 269.83€/year/child. The usual after-school care was estimated at 844,56€/year/child. Intervention children showed a decrease in triceps skinfold thickness (-1.25mm, 95% CI: -1.82 to -0.67; P P75 showed a decrease in triceps skinfold thickness (-1.87mm; 95%CI: -3.43 to -0.32; P<.001, and percentage of body fat (-0.67%; 95%CI: -1.32 to -0.01; P<.05. Conclusions: This type of after-school program for recreational physical activity to prevent obesity are likely to be a cost-effective use of public funds and warrant careful consideration by policy makers and program planners.

  16. Tutti i colori dell'universo

    CERN Multimedia

    Battiston, Roberto

    2009-01-01

    A partire dal 27 ottobre, una mostra sull'osservazione e lo studio dell'universo affronta la sfida di avvicinare il grande pubblico alle conoscenze scientifiche raccolte decrifrando l'alfabeto del cosmo. (4 pages)

  17. I figli della strada. Infanzia indifesa e abbandonata in Romania

    Directory of Open Access Journals (Sweden)

    Rita De Caris

    2010-02-01

    Full Text Available Intervento al Workshop Internazionale “Infanzie e Famiglie in Europa”, del 16 ottobre 2009, presso la Facoltà di Scienze della Formazione, Via Filippo Re, 6 Bologna (Aula Magna.

  18. Mängusõda / Jüri Kadak

    Index Scriptorium Estoniae

    Kadak, Jüri, 1941-

    1999-01-01

    Järg Jan/5;6;7;8;9;11;12;13;14;16;15;18;19;20;21;22;23;25;26;27;28;29;3; Feb/1;2;3;4;6;8;9;10;12;13;15;16;17;18;19;20;22;23. Sõja ja vastupanuta, poliitiliste mängude kaudu, on maha mängitud eestlaste maad. Riigipöördekatsed

  19. Consolidated Cab Display (CCD) System, Project Planning Document (PPD),

    Science.gov (United States)

    1981-02-01

    1980 1981 I 2 3 4 5 6 7 8 9 10 1112 1 2 3 4 5 6 7 8 9 1011112 1 2 31 12. Software Documentation a. Overall Computer Program Description ( OCPD ) b...Approve OCPD c. Computer Program Functional Specifications (CPFS) d. Data Base Table Design Specification (DBTDS) e. Software Interface Control Document...Parts List Master Pattern and Plan View Reproducible Drawings Instruction Book Training Aids/Materials b. Software: OCPD CPFS SI CD PDS DBTDS SDD

  20. Analysis of the η(548) ->π+π-π0 and η'(958) ->π+π- η channels using a 8-9 GeV tagged photon beam for the GlueX Experiment

    Science.gov (United States)

    Beattie, Tegan; Papandreou, Zisis; Stevens, Justin; GlueX Collaboration

    2016-09-01

    The primary goal of the GlueX experiment is to conduct a definitive mapping of states in the light meson sector with an emphasis on searching for exotic hybrid mesons as evidence of gluonic excitations. The experiment, housed in the Hall-D facility at Jefferson Lab following its accelerator upgrade to 12 GeV, is now entering the physics data taking phase. The η(548) and η'(958) mesons are two of the richest unflavoured light mesons readily available at GlueX energies for studying resonances. Many other light mesons have decay channels involving the η mesons with significant branching ratios, and πη / πη' resonances are among the top contenders for possibly-accessible exotic and hybrid resonances which GlueX aims to study. As such, the ability to reconstruct pure η/η' samples and analyze their decays is of utmost importance for understanding future work on more complicated analyses. Preliminary analysis results from commissioning data will be presented. This work was supported by NSERC Grant SAPJ-326516 and Jefferson Science Associates, LLC, who operates Jefferson Lab under U.S. DOE Contract No. DE-AC05-06OR23177.

  1. 9-Furfurylidene-2,3-dimethyl-6,7,8,9-tetrahydro-4H-thieno[2′,3′:4,5]pyrimidino[1,2-a]pyridin-4-one

    Directory of Open Access Journals (Sweden)

    Khusnutdin M. Shakhidoyatov

    2010-03-01

    Full Text Available The title compound, C17H16N2O2S, was obtained by condensation of 2,3-dimethylthieno[2′,3′:4,5]pyrimidino[1,2-a]pyridin-4-one with furfural in the presence of sodium hydroxide. One of the methylene groups of the tetrahydropyrido ring is disordered over two positions in a 0.87 (1:0.13 (1 ratio. The thieno[2,3-d]pyrimidin-4-one unit and the furan ring are both planar (r.m.s. deviation = 0.535 Å, and coplanar with each other, forming a dihedral angle of 5.4 (1°. Four weak intermolecular hydrogen bonds (C—H...O and C—H...N are observed in the structure, which join molecules into a network parallel to (101.

  2. Bis(2,2′-bipyridine[1,9-bis(diphenylphosphanyl-1,2,3,4,6,7,8,9-octahydropyrimido[1,2-a]pyrimidin-5-ium]ruthenium(II hexafluoridophosphate dibromide dichloromethane disolvate monohydrate

    Directory of Open Access Journals (Sweden)

    Alain Igau

    2013-12-01

    Full Text Available In the cation of the title complex, [Ru(C31H32N3P2(C10H8N22](PF6(Br2·2CH2Cl2·H2O, the ruthenium ion is coordinated in a distorted octahedral geometry by two 2,2′-bipyridine (bpy ligands and a chelating cationic N-diphenylphosphino-1,3,4,6,7,8-hexahydro-2-pyrimido[1,2-a]pyrimidine [(PPh22-hpp] ligand. The tricationic charge of the complex is balanced by two bromide and one hexafluoridophosphate counter-anions. The compound crystallized with two molecules of dichloromethane (one of which is equally disordered about a Cl atom and a water molecule. In the crystal, one of the Br anions bridges two water molecules via O—H...Br hydrogen bonds, forming a centrosymmetric diamond-shaped R42(8 motif. The cation and anions and the solvent molecules are linked via C—H...F, C—H...Br, C—H...Cl and C—H...O hydrogen bonds, forming a three-dimensional network.

  3. A 8.9-ENOB 2.5-εW 150-KS/s non-binary redundant successive approximation ADC in 0.18-microm CMOS for bio-implanted devices.

    Science.gov (United States)

    Chan, Kok Lim; Lee, Andreas Astuti; Yuan, Xiaojun; Krishna, Kotlanka R; Je, Minkyu

    2010-01-01

    A successive approximation analog-to-digital converter (SAR ADC) with a split-capacitor switching scheme implementing the generalized non-binary redundant SAR algorithm and an energy efficient level shifter is proposed for bio-implanted applications. The generalized non-binary redundant SAR algorithm removes the radix constraint in conventional non-binary redundant SAR algorithm, and the energy efficient level shifter allows optimal power supplies to be chosen independently for the analog and digital blocks. A FOM of 34.7fJ/step has been achieved.

  4. Lifecycle Cost Assessment of Fuel Cell Technologies for Soldier Power System Applications. Paper and Presentation for the 43rd Power Sources Conference held 8-9 July 2008, Philadelphia, PA

    Science.gov (United States)

    2008-07-09

    PEMFC in Federal Markets,” 2007 Fuel Cell Seminar, San Antonio, TX, 17 October 2007. 7. Fok, K., “Metal Hydride Fuel Cells: Increases in Power...Lauderdale, FL, March 17-20, 2008. 10. Zhao J., et al, “Reclaim/recycle of Pt/C catalysts for PEMFC ,” Energy Conversion and Management, vol. 48...hydrogen PEMFC or SOFC systems – Baratto et al, Journal of Power Sources – Citigroup, Dist. Telecom Backup – Battelle, Fuel Cell Seminar 2007 • Fuel

  5. (E-3-Hydroxy-13-methyl-16-[4-(methylsulfanylbenzylidene]-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H-one

    Directory of Open Access Journals (Sweden)

    R. Murugan

    2009-01-01

    Full Text Available In the title compound, C26H28O2S, the dihedral angles between the mean plane of the five membered ring and the 4-(methylsulfanylbenzylidine ring in the two crystallographically independent molecules are 34.05 (10 and 40.53 (15°. The packing is stabilized by intermolecular O—H...O and C—H...O interactions.

  6. Crystal structure of 2-(1,3,7,9-tetramethyl-2,4,6,8-tetraoxo-1,2,3,4,6,7,8,9-octahydropyrido[2,3-d:6,5-d′]dipyrimidin-5-ylbenzamide dimethylformamide hemisolvate

    Directory of Open Access Journals (Sweden)

    Armen Ayvazyan

    2014-10-01

    Full Text Available The title compound, C20H18N6O5·0.5C3H7NO, crystallized as a dimethylformamide (DMF solvate. In the main molecule, the dihedral angle between the pyridodipyrimidine fused-ring system and the benzamide substituent is 82.26 (11°. In the crystal, the benzamide molecules are linked by N—H...O hydrogen bonds to generate tetramers with an approximate square-prismatic shape, which appears to correlate with the tetragonal crystal symmetry. The DMF molecule is disordered about a crystallographic twofold axis and accepts a C—H...O interaction from the benzamide molecule.

  7. Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

    DEFF Research Database (Denmark)

    Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter

    2009-01-01

    The prevailing structural model for ligand activation of ionotropic glutamate receptors posits that agonist efficacy arises from the stability and magnitude of induced domain closure in the ligand-binding core structure. Here we describe an exception to the correlation between ligand efficacy and...

  8. Crystal structure of (1R,2S,4R,7R,8S,9R-3,3-dichloro-8,9-epoxy-4,8,12,12-tetramethyltricyclo[5.5.0.02,4]dodecane

    Directory of Open Access Journals (Sweden)

    Ahmed Benzalim

    2015-08-01

    Full Text Available The title compound, C16H24Cl2O, is built up from two fused six- and seven-membered rings which bear a dichlorocyclopropane group and an epoxy group, respectively. In the molecule, the six-membered ring adopts an envelope configuration with the C atom linking the epoxy ring at the flap, while the seven-membered ring adopts a boat–sofa conformation.

  9. Science, Technology, and Warfare. Proceedings of the Military History Symposium (3rd) Held at the United States Air Force Academy (Colorado Springs, Colorado) on 8-9 May 1969

    Science.gov (United States)

    1970-09-01

    case of long-range bom - bardment possibilities. Progression from the B-17 bomber to the B-29 to the B-36 had been straightforward, bigger and faster...in the hospital at Walter Reed waiting to go to Georgetown to be part of the Jesuit plot. So they sent me to the Pentagon for a few months and...graduate of Jesus College and an Oxford don until 1964, when he was appointed Profes- sor of History at the University of Warwick. Graduate work at

  10. In margine a un convegno. Gli intellettuali/scrittori ebrei e il dovere della testimonianza. Per Giorgio Bassani, “di là dal cuore” (Firenze, 7-8-9 novembre 2016

    Directory of Open Access Journals (Sweden)

    Martina Romanelli

    2016-12-01

    Full Text Available This brief article aims to investigate some aspects of an international conference held last November in Florence. In the year devoted to Giorgio Bassani, it was an occasion to address aspects of Jewish cultural data, with special reference to the reactions of writers in general and an individual in particular to the unspeakable horrors of the Holocaust. The conference acknowledged the need to face up to harsh reality and search for an adequate historiographical, ethical and literary response.

  11. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy"....

  12. Anticipating potential biodiversity conflicts for future biofuel crops in South Africa: incorporating spatial filters with species distribution models

    CSIR Research Space (South Africa)

    Blanchard, R

    2014-04-01

    Full Text Available @csir.co.za; 14 15 Keywords: Bioenergy crops, Land suitability, Biodiversity, Spatial analysis, MaxEnt, 16 Conflict, Agricultural land, Spatial filters 17 18 Primary research article 19 Page 1 of 48 GCB Bioenergy 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17... habitat transformation and provides 21 an objective means of mitigating potential conflict with existing land use and biodiversity. 22 23 Page 2 of 48GCB Bioenergy 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32...

  13. Metal-promoted cage rearrangements in the tricarbollide series: Conversion of ligand derivatives 7-L-nido-7,8,9-C3B8H10 (L=H3N, tBuH(2)N, Me2HN) into neutral 8-R-nido-7,8,9-C3B8H11 (R=H2N, tBuHN, Me2N) compounds

    Czech Academy of Sciences Publication Activity Database

    Grüner, Bohumír; Štíbr, Bohumil; Holub, Josef; Císařová, I.

    č. 8 (2003), s. 1533-1539 ISSN 1434-1948 R&D Projects: GA MŠk LN00A028; GA ČR GA203/00/1042 Institutional research plan: CEZ:AV0Z4032918 Keywords : boranes * carboranes * NMR spectroscopy Subject RIV: CA - Inorganic Chemistry Impact factor: 2.482, year: 2003

  14. Maui Optical Site, Mt. Halekulia, Hawaii, Revised Uniform Summary of Surface Weather Observations (RUSSWO) Parts C, E-F.

    Science.gov (United States)

    1980-09-23

    T.) * TOTAL LI TOOOTBRNC Tmp. WET BULB TEMPERATURE DEPRESION (F) TONT 3TOTL (F) 0 1 2 3 4 5 76 . 9 .10 11- 12 13 14 15 .16 17 .1 19. 20 21 .2223 24...BULB TEMPERATURE DEPRESION (F) TOTAL TOTAL (F) 0 1 .-2 3 .4 5.6 7 .8 9. 10 11. 12113. 14 15 .16 17 .111 9-2 21. 22 l . 2 3.24 25 .26 27.20 29 .30] a31.06

  15. Metabolic activation and DNA binding of benzo(a)pyrene in cultured human bronchus

    DEFF Research Database (Denmark)

    Yang, Shen K.; Gelboin, Harry V.; Trump, Benjamin F.

    1977-01-01

    . The predominant metabolite formed by human bronchus from the (-)-trans-7,8-diol is found by high-pressure liquid chromatographic analysis to be the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahy-drobenzo(a)pyrene. The results suggest that this diol-epoxide is the major benzo(a)pyrene metabolite bound...

  16. .la. Bing Tradutor br.bing.com/translator/ 0/5000. Opções de Voz. Masculina. Feminina. Traduzir. Português ... Faça mais com o Tradutor. Privacidade e Cookies · Legal · Anunciar · Sobre os nossos ... Pesquisas relacionadas a tradutor ingles portugues tradutor ingles portugues gratis on line tradutor ingles portugues online gratuito tradutor ingles portugues gratis online tradutor ingles portugues download tradutor ingles portugues yahoo tradutor ingles portugues uol tradutor ingles portugues babylon tradutor ingles portugues bussola 1 2 3 4 5 6 7 8 9 10 Mais

    Directory of Open Access Journals (Sweden)

    José Maria Ramos

    2016-06-01

    Full Text Available The market economy countries have significant concerns with the restraint of trade, requiring constitute regulatory frameworks and mechanisms to protect economic competition, so that economic efficiency is governed by legislation determined by the State. To mitigate the problems arising from the formation of a cartel that prevent free competition, causing damage to the community, the Office of the leniency agreement arises, administered by the Board of Directors and Economic Defense - CADE - the body responsible for prevention and repression of offenses against economic order. The leniency agreement is one of the most effective tools used by antitrust authorities to provide effective enforcement of antitrust law as regards the repression of anti-competitive practices although there are some contradictions in the field of ethics. In fulfilling the leniency agreement, the proposing informer may have the extinction of the punitive action or reduction of one to two thirds of the penalty applicable at the administrative level and in the criminal context, automatically terminate the punishment of crimes against the economic order.

  17. X-ray mapping in heterocyclic design: 18. X-ray diffraction study of a series of derivatives of 3-cyanopyridine-2-one with annelated heptane and octane cycles

    Energy Technology Data Exchange (ETDEWEB)

    Rybakov, V. B., E-mail: Rybakov20021@yandex.ru; Babaev, E. V. [Moscow State University, Faculty of Chemistry (Russian Federation); Paronikyan, E. G., E-mail: Ervand.paronikyan@mail.ru [National Academy of Sciences of Armenia, Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry (Armenia)

    2017-03-15

    Seven new, previously unknown, bicyclic and tricyclic heterocycles based on derivatives of 3-cyanopyrid-2-ones are obtained: 2-oxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile, C{sub 11}H{sub 12}N{sub 2}O (1a); 2-[2-(4-chlorophenyl)-2-oxoethoxy]-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridine-3-carbonitrile, C{sub 19}H{sub 17}ClN{sub 2}O{sub 2} (2a); (3-amino-6,7,8,9-tetrahydro-5H-cyclohepta[b]furo[3,2-e]pyridin-2-yl)(4- chlorophenyl)methanone, C{sub 19}H{sub 17}ClN{sub 2}O{sub 2} (3); 2-oxo-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carboxamide, C{sub 12}H{sub 16}N{sub 2}O{sub 2} (4); 2-[2-(4-chorophenyl)-2-oxoethoxy]-5,6,7,8,9,10 -hexahydrocycloocta[b]pyridine-3-carboxamide, C{sub 20}H{sub 21}ClN{sub 2}O{sub 3} (5a); 1-[2-(4-chlorophenyl)-2-oxoethyl]-2-oxo-1,2,5,6,7,8,9,10 -octahydrocycloocta[b]pyridine-3-carboxamide, C{sub 20}H{sub 21}ClN{sub 2}O{sub 3} (5b); and 2-[2-(4-chlorophenyl)-2-oxoethoxy]-5,6,7,8,9,10-hexahydrocycloocta[b] pyridine-3-carbonitrile, C{sub 20}H{sub 19}ClN{sub 2}O{sub 2}, (6). All compounds are characterized by {sup 1}H NMR spectroscopy, and their crystal structures are determined by X-ray diffraction.

  18. Meat studies of indigenous Southern African cattle. II. Textural ...

    African Journals Online (AJOL)

    stimulated electrically (500 V 12,5Hz for 2 min, polarity changes per 30 s). The right wingrib (ribs 11, 12, 13) was removed for determining the intramuscular fat of the longis- simus thoracis. Cooking loss (Naude, 1974), shear force and free water were determined on the longissimus thoracis of the left primerib (ribs 8, 9, 10).

  19. Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vivo and in vitro

    DEFF Research Database (Denmark)

    Weinstein, I.B.; Jeffrey, A.M.; Jennette, K.W.

    1976-01-01

    Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is for...

  20. Application possibilities of the Mesulam Continuous Performance ...

    African Journals Online (AJOL)

    Erna Kinsey

    seven years in a variety of settings, such as at school or at home, and should have resulted ... ponded that ADHD is a bogus disorder in an opinion poll on the disorder ... with the child, parent(s) or a teacher and imply a thorough know- ... English. Xhoza. Gender. Male. Female. Age (years) *. 6. 7. 8. 9. 10. Grade. 1. 2. 3. 527.

  1. Variability of the Date of Monsoon Onset over Kerala (India) of the ...

    Indian Academy of Sciences (India)

    19

    Nansen Environmental Research Centre India,6A Oxford Business Centre, Kochi - ... Monsoon Onset over Kerala (India) which occurs every year is a major ... Decadal variability in DMOK. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18.

  2. Trajectories of Attentional Development: An Exploration with the Master Activation Map Model

    Science.gov (United States)

    Michael, George A.; Lete, Bernard; Ducrot, Stephanie

    2013-01-01

    The developmental trajectories of several attention components, such as orienting, inhibition, and the guidance of selection by relevance (i.e., advance knowledge relevant to the task) were investigated in 498 participants (ages 7, 8, 9, 10, 11, and 20). The paradigm was based on Michael et al.'s (2006) master activation map model and consisted of…

  3. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    Background: Cholelithiasis is a very common condition which may be complicated by the ... surgeons tried to push CBDS into the duodenum.8,9,10 The rate of retained .... biliary anatomy at operation to help avoid or recognize bile duct injury.

  4. Cytotoxic flavonoids from Erythrina caffra Thunb | Y. Desta | Bulletin ...

    African Journals Online (AJOL)

    Erythrina caffra is an important medicinal plant native to South Africa. Its stem bark was investigated for the flavonoid constituents and biological activity. Some isolated flavonoids, 3, 5, 6, 8, 9, 10, 11, 12, 13, 15 and 16 were found to be active against the human cervix carcinoma KB-3-1 cells with IC50 values in the ...

  5. High content screening: science, techniques, and applications

    National Research Council Canada - National Science Library

    Haney, Steven A

    2008-01-01

    ... Workflow - Flexibility is the Key 1.7.6 HCS is Hard - How Do I Learn It and Become Proficient at It? 1.5 1.6 1.7 References 3 4 5 8 9 10 11 11 12 13 13 15 16 18 18 19 20 20 21 21 22 viiviii CONTEN...

  6. Internal consistency reliability and construct validity of the Dutch translation of the Francis Scale of Attitude toward Christianity among adolescents.

    Science.gov (United States)

    Francis, L J; Hermans, C A

    2000-02-01

    A sample of 1,021 young people attending Years 7, 8, 9, 10, and 11 at Catholic secondary schools within the state-maintained sector completed the Dutch translation of the Francis Scale of Attitude toward Christianity. The data support its reliability and validity and commend it for further use in studies conducted among young people in The Netherlands.

  7. 49 CFR Schedule E to Subpart B of... - Statement of Changes in Financial Position

    Science.gov (United States)

    2010-10-01

    ...__ (d) Base year-actual (e) sources of working capital Working capital provided by operations: 1Net... working capital (subtract) credits not generating working capital: 2Loss (gain) on sale or disposal of...) 7Other (specify): 8 9 10 11 12 13 14 15 16 17 18Total working capital from operations before...

  8. Gradient Space under Orthography and Perspective

    Science.gov (United States)

    1982-05-24

    surfaceorientation to image geometry [8, 9, 10, 13, 15]. The descriptions of important gradient space properties, however, have been scattered throughout...Kanade, T. A Theory of Origami World. Artificial Intelligence 13:279-311, 1980. *[8] Kanade, T. and Kender, J. Mapping Image Properies into Shape

  9. Hard Incongruence Between ITS and Plastid Phylogenetic Trees in Amaryllidaceae Tribe Hippeastreae (Asparagales)

    Science.gov (United States)

    Amaryllidaceae tribe Hippeastreae constitutes a horticulturally valuable group of American endemics, characterized by disploidy and polyploidy (x = 5, 6, 8, 9, 10, 11, 12; 2n = 10-150). It is a clade putatively descended (in part) from an ancient hybridization event. Its taxonomy at the generic leve...

  10. European gene mapping project (EUROGEM) : Breakpoint panels for human chromosomes based on the CEPH reference families

    NARCIS (Netherlands)

    Attwood, J; Bryant, SP; Bains, R; Povey, R; Povey, S; Rebello, M; Kapsetaki, M; Moschonas, NK; Grzeschik, KH; Otto, M; Dixon, M; Sudworth, HE; Kooy, RF; Wright, A; Teague, P; Terrenato, L; Vergnaud, G; Monfouilloux, S; Weissenbach, J; Alibert, O; Dib, C; Faure, S; Bakker, E; Pearson, NM; Vossen, RHAM; Gal, A; MuellerMyhsok, B; Cann, HM; Spurr, NK

    Meiotic breakpoint panels for human chromosomes 2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 17; 18, 20 and X were constructed from genotypes from the CEPH reference families. Each recombinant chromosome included has a breakpoint well-supported with reference to defined quantitative criteria. The panels

  11. The Development of Scientific Thinking in Elementary School: A Comprehensive Inventory

    Science.gov (United States)

    Koerber, Susanne; Mayer, Daniela; Osterhaus, Christopher; Schwippert, Knut; Sodian, Beate

    2015-01-01

    The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experimental design, data…

  12. The effects of age on muscle texture and eating qualities of the ...

    African Journals Online (AJOL)

    An experiment was conducted to test the effect of age on the eating qualities of broiler chickens slaughtered at 7, 8, 9, 10, 11 and 12 weeks of age for the Nigerian consumers. The birds that provided the meat for the experiment were raised conventionally. Thigh and drumstick meat of the ovenroasted chickens were ...

  13. ATLAS Pixel Group - Photo Gallery from Irradiation

    CERN Multimedia

    2001-01-01

    Photos 1,2,3,4,5,6,7 - Photos taken before irradiation of Pixel Test Analog Chip and Pmbars (April 2000) Photos 8,9,10,11 - Irradiation of VDC chips (May 2000) Photos 12, 13 - Irradiation of Passive Components (June 2000) Photos 14,15, 16 - Irradiation of Marebo Chip (November 1999)

  14. Studies on the potency of oral polio vaccine using RD cell line and ...

    African Journals Online (AJOL)

    Studies on the potency of oral polio vaccine using RD cell line and evaluation of growth using different serum concentration and volume of media. ... The culture flasks containing different volumes of growth medium with 10% serum concentration such as 8, 9, 10, 11 and 12 ml were added to a series of culture flasks. All the ...

  15. Characterization of middle Eocene tide-influenced delta: a study ...

    Indian Academy of Sciences (India)

    42

    Running Title: Eocene tide-influenced delta in South Cambay Basin. Manuscript. Click here to view linked References. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10 .... systematic documentation of the facies types to establish the depositional environment of the .... Hazad Member consists of a number of sandstone units separated by intervening ...

  16. Kümme kümnendit / Alo Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Alo

    1999-01-01

    Järg Dec/2;3;4;6;7;8;9;10;11 lk. 24;24;20;28;28;28;24;24;20 Tähtsamatest ajaloosündmustest Eestis 20. sajandil: 1901 - 1910, 1911 - 1920, 1931 - 1940, 1941 - 1950, 1951 - 1960, 1961 - 1970, 1971 - 1980, 1981 - 1990, 1991 - 2000

  17. Endosulfan has no adverse effect on soil respiration

    Science.gov (United States)

    Endosulfan (6,7,8,9,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide) is a chlorinated hydrocarbon used as a broad spectrum contact insect/acaricide. The continuous agricultural production of tomatoes, green beans, and squash make Miami-Dade County, Florida one of th...

  18. A Review of the Appropriateness of User Fees and Social Health ...

    African Journals Online (AJOL)

    Alasia Datonye

    are key strategies of healthcare funding. These strategies ... 7-8. 9, 10 per capita lower middle-income as countries whose per capita ... financial protection to the populace The World Bank has classified ... formulation and implementation of good health policies ..... health.ch/health/health.health/user_fees_in_health-.

  19. Excerpts from Saudi Ministry of Education Textbooks for Islamic Studies: Arabic with English Translation

    Science.gov (United States)

    Center for Religious Freedom, 2006

    2006-01-01

    This appendix is a companion document to "Saudi Arabia's Curriculum of Intolerance with Excerpts from Saudi Ministry of Education Textbooks for Islamic Studies." The appendix includes selected excerpts in Arabic with English translations for currently-used textbooks in grades 1, 4, 5, 6, 8, 9, 10, 11, and 12. These excerpts support the…

  20. Denaturation and in Vitro Gastric Digestion of Heat-Treated Quinoa Protein Isolates Obtained at Various Extraction pH

    NARCIS (Netherlands)

    Ruiz, Geraldine Avila; Opazo-Navarrete, Mauricio; Meurs, Marlon; Minor, Marcel; Sala, Guido; Boekel, van Tiny; Stieger, Markus; Janssen, Anja E.M.

    2016-01-01

    The aim of this study was to determine the influence of heat processing on denaturation and digestibility properties of protein isolates obtained from sweet quinoa (Chenopodium quinoa Willd) at various extraction pH values (8, 9, 10 and 11). Pretreatment of suspensions of protein isolates at 60,

  1. CLIMA 2016 - proceedings of the 12th REHVA World Congress:volume 3

    OpenAIRE

    2016-01-01

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings.This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy".

  2. The increasing problem of whiplash-injury in The Netherlands. Paper presented at the Global Strategies Meeting of the Physical Medicine Research Foundation, Vancouver, 9-10 February 1999.

    NARCIS (Netherlands)

    Wegman, F.C.M. & Kampen, L.T.B. van

    2014-01-01

    Dutch (police based) accident data show a tremendous increase over the years of the number of rear-end collisions with cars, while the total number of injury accidents has remained more or less at the same level. The increase of traffic, especially regarding cars and vans, without expanding the road

  3. Superradiant properties of 4,4'-bis(1¤H¤-phenanthro[9,10-¤d¤]imidazol-2-yl)biphenyl and how a laser dye with exceptional stability can be obtained in only one synthetic step

    DEFF Research Database (Denmark)

    Krebs, Frederik C; Lindvold, Lars René; Jørgensen, M.

    2001-01-01

    The extremely facile synthesis of a very stable laser dye with superradiant properties is reported. The laser action of the dye is demonstrated through a transverse pumping scheme with the advantage that no elaborate laser resonator is required due to the very high gain of the laser medium...

  4. (4aS,10aS-7-Hydroxy-8-isopropyl-1,1,4a-trimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene: a new diterpenoid compound

    Directory of Open Access Journals (Sweden)

    Ahmed Benharref

    2008-03-01

    Full Text Available The new title diterpenoid compound, C20H30O, is a natural product isolated from Tetraclinis articulata wood via chloroform extraction. The asymmetric unit contains four molecules with the same S,S configuration, deduced from the chemical synthesis. Indeed, an overlay analysis, calculated using structure-matching software, shows that the four molecules can be superimposed. The central ring has a half-chair conformation, whereas the saturated ring displays a chair conformation.

  5. CCDC 1442746: Experimental Crystal Structure Determination : dimethyl 2,2'-(anthracene-9,10-diylbis(oxy(1-oxoethane-2,1-diyl)imino))bis(3-(1H-imidazol-4-yl)propanoate)

    KAUST Repository

    Patil, Sachin P.; Moosa, Basem A.; Alsaiari, Shahad; Alamoudi, Kholod; Alshamsan, Aws; AlMalik, Abdulaziz; Adil, Karim; Eddaoudi, Mohamed; Khashab, Niveen M.

    2016-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  6. 9-(3-Bromo-5-chloro-2-hydroxyphenyl-10-(2-hydroxyethyl-3,6-diphenyl-3,4,9,10-tetrahydroacridine-1,8(2H,5H-dione

    Directory of Open Access Journals (Sweden)

    Mehmet Akkurt

    2014-06-01

    Full Text Available In the title compound, C33H27BrClNO4, the dihydropyridine ring adopts a flattened boat conformation. The molecular conformation is stabilized by an intramolecular O—H...O hydrogen bond, with an S(8 ring motif. In the crystal, O—H...O, C—H...O and C—H...Cl hydrogen bonds, and C—H...π interactions link the molecules, forming a three-dimensional network. In the acridinedione ring system, the two ring C atoms at the 2- and 3-positions, and the C atom at the 6-position and the atoms of the phenyl ring attached to the C atom at the 6-position are disordered over two sets of sites with occupancy ratios of 0.783 (5:0.217 (5 and 0.526 (18:0.474 (18, respectively.

  7. EERE Quality Control Workshop Final Report: Proceedings from the EERE Quality Control Workshop, in support of the DOE Clean Energy Manufacturing Initiative; Golden, Colorado, December 9-10, 2013

    Energy Technology Data Exchange (ETDEWEB)

    2014-05-01

    The U.S. Department of Energy Office of Energy Efficiency & Renewable Energy (EERE) has recognized the cross-cutting, pre-competitive and enabling nature of quality control for a wide range of clean energy technologies. As such, the Fuel Cell Technologies Office, Solar Energy Technologies Office, Vehicle Technologies Office, Building Technologies Office, and Advanced Manufacturing Office decided to explore needs and potential cross-office synergies in this area by holding the EERE Quality Control Workshop, in support of the DOE Clean Energy Manufacturing Initiative. This report summarizes the purpose and scope of the workshop; reviews the current status and state-of-the-art for in-line quality control; summarizes the results from three breakout sessions; and presents conclusions and recommendations.

  8. 10a-Hydroxy-9-(4-methoxyphenyl-3,4,5,6,7,8a,9,10a-octahydro-1H-xanthene-1,8(2H-dione

    Directory of Open Access Journals (Sweden)

    Hoong-Kun Fun

    2012-08-01

    Full Text Available In the title compound, C20H22O5, the tetrahydropyran, cyclohexene and cyclohexane rings of the xanthene ring system adopt half-chair, half-boat and chair conformations, respectively. The mean plane of the four roughly planar atoms of the tetrahydropyran ring (r.m.s. deviation = 0.111 Å forms a dihedral angle of 82.91 (4° with the methoxybenzene group. In the crystal, molecules are linked via O—H...O and C—H...O hydrogen bonds into sheets lying parallel to the ac plane. The crystal is further consolidated by weak C—H...π interactions.

  9. (1S,3R,8S,9R,10S-2,2-Dichloro-3,7,7,10-tetramethyl-9,10-epoxytricyclo[6.4.0.01,3]dodecane

    Directory of Open Access Journals (Sweden)

    Moha Berraho

    2010-12-01

    Full Text Available The title compound, C16H24Cl2O, was synthesized from β-himachalene (3,5,5,9-tetramethyl-2,4a,5,6,7,8-hexahydro-1H-benzocycloheptene, which was isolated from the essential oil of the Atlas cedar (cedrus atlantica. The molecule forms an extended sheet of two fused rings which exhibit different conformations. The six-membered ring has a half-chair conformation, while the seven-membered ring displays a chair conformation; the dihedral angle between the two rings is 38.2 (1°.

  10. Conjugation of a 3-(1H-phenanthro[9,10-d]imidazol-2-yl)-1H-indole intercalator to a triplex oligonucleotide and to a three-way junction

    DEFF Research Database (Denmark)

    Fatthalla, Maha I.; Elkholy, Yehya M; Abbas, Nermeen S

    2012-01-01

    a phenanthroimidazole moiety linked to the indole ring. Insertion of the new intercalator as a bulge into a Triplex Forming Oligonucleotide resulted in good thermal stability of the corresponding Hoogsteen-type triplexes. Molecular modeling supports the possible intercalating ability of M. Hybridisation properties...

  11. Datasets in Gene Expression Omnibus used in the study ORD-019001: Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.

    Data.gov (United States)

    U.S. Environmental Protection Agency — Accession numbers of microarray data sets used in the analysis. This dataset is associated with the following publication: Kumar, R., L. Mota, E. Litoff, J. Rooney,...

  12. (4bS,8aS-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-yl benzoate

    Directory of Open Access Journals (Sweden)

    Radouane Oubabi

    2014-08-01

    Full Text Available The title compound, C27H34O2, was hemisynthesized through direct benzoylation of the naturally occurring meroterpene totarol. The central fused six-membered ring has a half-chair conformation, whereas the terminal six-membered ring displays a chair conformation. The dihedral angle between the fused benzene ring and the benzoyl benzene ring is 73.05 (14°. The S,S chirality of the molecule is consistent with the synthetic pathway, and confirmed by the refinement of the Flack parameter.

  13. Valence-State Alternatives in Diastereoisomeric Complexes [(acac)2Ru(.mu.-QL)Ru(acac)2]n (QL2- = 1,4-Dioxido-9,10-anthraquinone, n = +2, +1, 0, -1, -2)

    Czech Academy of Sciences Publication Activity Database

    Maji, S.; Sarkar, B.; Mobin, S. M.; Fiedler, Jan; Urbanos, F. A.; Jimenez-Aparicio, R.; Kaim, W.; Lahiri, G. K.

    2008-01-01

    Roč. 47, č. 12 (2008), s. 5204-5211 ISSN 0020-1669 R&D Projects: GA MŠk OC 140; GA MŠk LC510 Institutional research plan: CEZ:AV0Z40400503 Keywords : diastereoisometric complexes * spectroelectrochemistry * EPR Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.147, year: 2008

  14. PROCEEDINGS OF THE 2003 NATIONAL OILHEAT RESEARCH ALLIANCE TECHNOLOGY SYMPOSIUM, HELD AT THE 2003 NEW ENGLAND FUEL INSTITUTE CONVENTION AND 30TH NORTH AMERICAN HEATING AND ENERGY EXPOSITION, HYNES CONVENTION CENTER, PRUDENTIAL CENTER, BOSTON, MASSACHUSETTS, JUNE 9 - 10, 2003.

    Energy Technology Data Exchange (ETDEWEB)

    MCDONALD,R.J.

    2003-06-09

    This meeting is the sixteenth oilheat industry technology meeting held since 1984 and the third since the National Oilheat Research Alliance (NORA) was formed. This year's symposium is a very important part of the effort in technology transfer, which is supported by the Oilheat Research Fuel Flexibility Program under the United States Department of Energy, Distributed Energy and Electricity Reliability Program (DEER). The foremost reason for the conference is to provide a platform for the exchange of information and perspectives among international researchers, engineers, manufacturers, service technicians, and marketers of oil-fired space-conditioning equipment. The conference provides a conduit by which information and ideas can be exchanged to examine present technologies, as well as helping to develop the future course for oil heating advancement. These conferences also serve as a stage for unifying government representatives, researchers, fuel oil marketers, and other members of the oil-heat industry in addressing technology advancements in this important energy use sector. The specific objectives of the conference are to: (1) Identify and evaluate the current state-of-the-art and recommend new initiatives for higher efficiency, a cleaner environment, and to satisfy consumer needs cost effectively, reliably, and safely; (2) Foster cooperative interactions among federal and industrial representatives for the common goal of sustained economic growth and energy security via energy conservation.

  15. Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice

    Science.gov (United States)

    Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we ...

  16. Production of Self-Purifying Proteins in a Variety of Expression Hosts with Focus on Organophosphorus Hydrolase

    Science.gov (United States)

    2012-08-17

    Manley ,  R.G.  Options  for...0.0015 0.001 0 .0005 0 4 Average Product Yields .... ..... ... • • 5 6 7 8 9 ELP (SOX) Amino Acids • 10 11 12 160 140 "’C 120 -0 LL ...0.005 0 4 5 6 7 8 9 10 11 12 ELP Length (SOX) Amino Acids so 45 "’C 40 -0 35 LL c:: 0 30 ·-..... 25 ro u 20 ·-’+-·-s... ::s 15 0.. 10

  17. La ‘Société’ a Barcellona

    NARCIS (Netherlands)

    Abatino, B.

    2011-01-01

    Cronaca di convegno, su: LXIV Session della Société internationale F. de Visscher che si è tenuta dal 28 settembre al 2 ottobre 2010, presso il Campus della Universidad Autónoma, sul tema «Comunicazione e pubblicità nell’antichità: profili giuridici, sociali, economici».

  18. Aernout van Buchel in Napels

    NARCIS (Netherlands)

    de Jong, Jan; Kemper, J.A.R.

    2012-01-01

    Aernout van Buchel a Napoli Il 18 ottobre 1587, dopo un viaggio in Germania, il giovane studioso olandese Aernout van Buchel (Buchellio/Arnoldus Buchellius) da Utrecht arrivò in Italia. Il suo scopo fu visitare Roma ed esaminare, con i propri occhi, i monumenti e le iscrizioni dell’Antichità. Fin da

  19. Roma locuta, causa (quasi finita. La controversia Roma – Conferenza episcopale tedesca in merito ai consultori per le gestanti

    Directory of Open Access Journals (Sweden)

    Stefano Testa Bappenheim

    2011-03-01

    Full Text Available Comunicazione destinata agli atti del convegno “Benedetto XVI: quali riflessi sul postconcilio?”, 13-14 ottobre 2006, organizzato dalla cattedra di diritto ecclesiastico della Facoltà di Giurisprudenza, Università di Teramo (Prof. Zanchini di Castiglionchio.

  20. Dopo la rivoluzione francese, non il diluvio, ma il contratto congreganista

    Directory of Open Access Journals (Sweden)

    Stefano Testa Bappenheim

    2011-03-01

    Full Text Available Relazione destinata agli Atti del convegno “La Chiesa e l’Europa”, 28-29 ottobre 2005, organizzato dalla cattedra di diritto ecclesiastico della Facoltà di Giurisprudenza (Prof. Leziroli Università di Ferrara.

  1. Mountain Home AFB, Mountain Home, Idaho. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

    Science.gov (United States)

    1980-03-10

    DEPRESSIO ?~F OA TOTAL () 0 1 .2 3. 4 5-6 78 9- 10 11-12 13 -14 15 -1617.-18,19. 2br2I. 22123 -24 125. 26j27 -28j29.30, 53) OB’..,BlbWt1b~w~ * 100/ 9 91...1 1500-1700 "OURS IL. S. T.) Temp. WET BULB TEMPERATURE DEPRESSIO i (F) TOTAL I TOTAL (F) 0 I-2 3.4 5.6 7-8 9-10 1! 12 13-]4 15-16 17.18 19 .202. 22

  2. Activated and deactivated functional brain areas in the Deqi state: A functional MRI study.

    Science.gov (United States)

    Huang, Yong; Zeng, Tongjun; Zhang, Guifeng; Li, Ganlong; Lu, Na; Lai, Xinsheng; Lu, Yangjia; Chen, Jiarong

    2012-10-25

    We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects during acupuncture. Twelve healthy volunteers received sham and true needling at the Waiguan (TE5) acupoint. Real-time cerebral functional MRI showed that compared with non-sensation after sham needling, true needling activated Brodmann areas 3, 6, 8, 9, 10, 11, 13, 20, 21, 37, 39, 40, 43, and 47, the head of the caudate nucleus, the parahippocampal gyrus, thalamus and red nucleus. True needling also deactivated Brodmann areas 1, 2, 3, 4, 5, 6, 7, 9, 10, 18, 24, 31, 40 and 46.

  3. Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. Synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (-)-allocolchicine.

    Science.gov (United States)

    Djurdjevic, Sinisa; Yang, Fei; Green, James R

    2010-12-03

    The preparation of dibenzocycloheptyne-Co(2)(CO)(6) complexes by intramolecular Nicholas reactions of biaryl-2-propargyl alcohol-Co(2)(CO)(6) derivatives is described. Reductive decomplexation of the dibenzocycloheptyne-Co(2)(CO)(6) complexes affords the corresponding dibenzocycloheptenes, individual members of which have been employed in a formal total synthesis of (-)-allocolchicine, the preparation of 6,7-dihydro-3,4,9,10,11-pentamethoxy-5H-dibenzo[a,c]cyclohepten-5-one, and the enantioselective total syntheses of NSC 51046 and its 3,8,9,10-tetramethoxy regioisomer.

  4. Green chemistry: highly selective biocatalytic hydrolysis of nitrile compounds

    CSIR Research Space (South Africa)

    Brady, D

    2006-02-28

    Full Text Available O N +O O OH O N N +O O OH O R O O O S OO NH2 O O O O 1 R = H 2 R = CH3 3 R = NH2 4 R = OH 5 R = CH2CH3 6 R = H 7 R = OH 8 9 10 R1 = CH3, R2 = H 11 R1 = OCH3, R2 = OCH3 12 13 14 15 16 17 R = Br 18 R = C(O)OCH2CH3 19 R... CN NH2 CN O O CN CN CN CN CN CN CN CN CN CN CN NC CN Cl CN N CN OH CN CN NC NC CN NH2 NH2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Slide 32 © CSIR 2006 www.csir.co.za Beta-amino compounds N...

  5. Natural selection on protein-coding genes in the human genome

    DEFF Research Database (Denmark)

    Bustamente, Carlos D.; Fledel-Alon, Adi; Williamson, Scott

    2005-01-01

    , showing an excess of deleterious variation within local populations 9, 10 . Here we contrast patterns of coding sequence polymorphism identified by direct sequencing of 39 humans for over 11,000 genes to divergence between humans and chimpanzees, and find strong evidence that natural selection has shaped......Comparisons of DNA polymorphism within species to divergence between species enables the discovery of molecular adaptation in evolutionarily constrained genes as well as the differentiation of weak from strong purifying selection 1, 2, 3, 4 . The extent to which weak negative and positive darwinian...... selection have driven the molecular evolution of different species varies greatly 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 , with some species, such as Drosophila melanogaster, showing strong evidence of pervasive positive selection 6, 7, 8, 9 , and others, such as the selfing weed Arabidopsis thaliana...

  6. Development of high-power and high-energy 2 µm bulk solid-state lasers and amplifiers

    CSIR Research Space (South Africa)

    Koen, W

    2016-04-01

    Full Text Available 250 300 350 Pulse Repetition Frequency [Hz] P u l s e E n e r g y [ m J ] 0 1 2 3 4 5 6 7 8 9 10 A v e r a g e P o w e r [ W ] Osc Energy Amp Energy Osc average P Amp average P Figure 8: Output energy of the ring laser and amplifier...

  7. Role of Integrin Alpha 5 in ErbB2-Mediated Breast Cancer

    Science.gov (United States)

    2009-09-01

    AD__ ( Leave blank) _______________ Award Number: W81XWH-08-1...3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 using Guava Technologies EasyCyte Plus, and data analyzed with Guava ...dilution, washed, and incubated with secondary antibody (AlexaFluor mouse 488, Invitrogen) at a 1:200 dilution. Cells were read on a Guava Technologies

  8. Helium Adsorption on Carbon Nanotube Bundles with Different Diameters:. Molecular Dynamics Simulation

    Science.gov (United States)

    Majidi, R.; Karami, A. R.

    2013-05-01

    We have used molecular dynamics simulation to study helium adsorption capacity of carbon nanotube bundles with different diameters. Homogeneous carbon nanotube bundles of (8,8), (9,9), (10,10), (11,11), and (12,12) single walled carbon nanotubes have been considered. The results indicate that the exohedral adsorption coverage does not depend on the diameter of carbon nanotubes, while the endohedral adsorption coverage is increased by increasing the diameter.

  9. Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.

    Science.gov (United States)

    Weinstein, I B; Jeffrey, A M; Jennette, K W; Blobstein, S H; Harvey, R G; Harris, C; Autrup, H; Kasai, H; Nakanishi, K

    1976-08-13

    Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.

  10. 41 CFR 101-25.405 - Materials handling equipment.

    Science.gov (United States)

    2010-07-01

    ... 50 45 40 30 25 20 15 10 Straddle truck 15 50 50 50 45 45 45 40 40 35 35 30 25 20 15 10 Electric Fork... percentage of acquisition costs (years in use) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Gasoline Fork truck (2000 pounds to 6000 pounds) 8 50 45 40 30 25 20 15 10 Fork truck (over 6000 pounds) 10 50 45 40 35 30 25 20 15...

  11. Visible-light-induced hydrogen evolution reaction with WS2-xSex

    Indian Academy of Sciences (India)

    20

    1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. Page 2. 1. Introduction. Transition metal dichalcogenides (TMDs) have emerged as an ...

  12. Association of gait and balance disorders with age-related white matter changes: the LADIS study

    DEFF Research Database (Denmark)

    Baezner, H.; Blahak, C.; Poggesi, A.

    2008-01-01

    : 10.2 +/- 2.1 in the mild, 9.9 +/- 2.0 in the moderate, 8.9 +/- 2.6 in the severe group; p p ... was best in individuals with mild ARWMC (single leg stance time: 18.9 +/- 10.8 seconds) compared with moderate and severe ARWMC (16.4 +/- 10.8 and 13.6 +/- 11.2 seconds) (p

  13. Rootless calc-silicate folds in granite: An implication towards syn to ...

    Indian Academy of Sciences (India)

    36

    southernmost extension of the Southern Aravalli Mountain Belt (SAMB) in Gujarat and is. 24 located at the junction between the two older sequences, viz. the Lunavada Group in the north. 25. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39.

  14. An Uncertain Relationship: Special Operations and Clausewitz’s on War

    Science.gov (United States)

    2011-05-04

    Conclusion Bibliography 11 lll 7 8 9 10 11 12 13 15 17 18 20 22 23 24 27 5 Shakespeare offers only an incomplete truth in noting, "[t...execution 1 William Shakespeare , "Coriolanus," V, iii, 141. 6 of speciai operations, and reveals that contemporary models for synchronizing the role of...Those overawed by the uncertainty Shakespeare ascribes to war might "profess . ourselves to be the slaves of chance, and flies. of every wind that

  15. High-Energy, High-Pulse-Rate Light Sources for Enhanced Time-Resolved Tomographic PIV of Unsteady and Turbulent Flows

    Science.gov (United States)

    2017-07-31

    ultimately, may lead to revolutionary practical methods for the prediction and control of unsteady and turbulent flow. Recent work suggests a class...Recent work suggests a class of exact Navier-Stokes solutions termed “Exact Coherent Structures” (ECS) [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12] may...velocimetry. In the Taylor-Couette geometry, walls are always in close proximity to the flows of interest; thus, interrogation of fluorescing particles

  16. Long and Short-Term Memory Processes in Cortically Damaged Patients.

    Science.gov (United States)

    1981-01-01

    appropriateness, but admissions to hospitals are biased by holidays, time of year, socioeconomic status, etc.; therefore, most investigators prefer a policy of...1 2 3 4 5 6 7 8 9 10 TRIALS TOTAL RECALL HIGH~1 FREOUENC1IAGERY WORDS FIGURE I 9. 77 N C-0 6I 00 00 ’ q P’ . v; C U,- OD P W k It CIJ0 CnCD - tOqT r

  17. Real-Time NDE Using Multi-Function Robotic Sonoscope (MSRF)

    Science.gov (United States)

    1991-12-31

    was caused by a 0.16 Xc impacto - a"L a s?eed of 6-7 m/s. The field of view is 45 ran x 2 6 mm Mass 0.16 Kg Velocity = 6.70 m...3J tic . (c) SLAM inage of Specimen C3. ?ig. 6 (c) SLAM irrage of Scecimer. C^ 3£ 0 1 2 3 4 5 6 7 8 9 10 *! T ±± 12 13

  18. Impact of Liquid Propellant Properties on Small Energy Conversion Device Dimensions

    Science.gov (United States)

    2012-05-01

    William Hargus, Ph . D. Date...conductivity in the absence of measured data in this temperature regime, use of a surrogate molecule that is also polar and of similar molecular weight...Physically this is sensible since for a fixed thrust level, there is a fixed amount of gas 0 100 200 300 400 500 600 1 2 3 4 5 6 7 8 9 10 11

  19. Managing government employees: how to motivate your people, deal with difficult issues, and achieve tangible results

    National Research Council Canada - National Science Library

    Liff, Stewart

    2007-01-01

    ..., Benefits, and Retirement They Want the Job Security Offered by Government The Government Can Offer the Right Job and Training The Government Offers Many Opportunities to Advance Why Do Government Personnel Systems Make Things So Difficult? 1 1 2 3 4 4 5 7 8 9 10 11 11 12 12 12 13 vii ... 16220$ CNTS 11-14-06 08:22:32 PS PAGE viiviii Contents History of t...

  20. ACER Mathematics Profile Series: Number Test. (Test Booklet, Answer and Record Sheet, Score Key, and Teachers Handbook).

    Science.gov (United States)

    Cornish, Greg; Wines, Robin

    The Number Test of the ACER Mathematics Profile Series, contains 30 items, for each of three suggested grade levels: 7-8, 8-9, and 9-10. Raw scores on all tests in the ACER Mathematics Profile Series (Number, Operations, Space and Measurement) are converted to a common scale called MAPS, a major feature of the Series. Based on the Rasch Model,…