Gain-of-function analysis of poplar CLE genes in Arabidopsis by exogenous application and over-expression assays.

Science.gov (United States)

Liu, Yisen; Yang, Shaohui; Song, Yingjin; Men, Shuzhen; Wang, Jiehua

2016-04-01

Among 50 CLE gene family members in the Populus trichocarpa genome, three and six PtCLE genes encode a CLE motif sequence highly homologous to Arabidopsis CLV3 and TDIF peptides, respectively, which potentially make them functional equivalents. To test and compare their biological activity, we first chemically synthesized each dodecapeptide and analysed itsi n vitro bioactivity on Arabidopsis seedlings. Similarly, but to a different extent, three types of poplar CLV3-related peptides caused root meristem consumption, phyllotaxis disorder, anthocyanin accumulation and failure to enter the bolting stage. In comparison, application of two poplar TDIF-related peptides led to root length promotion in a dose-dependent manner with an even stronger effect observed for poplar TDIF-like peptide than TDIF. Next, we constructed CaMV35S:PtCLE transgenic plants for each of the nine PtCLE genes. Phenotypic abnormalities exemplified by arrested shoot apical meristem and abnormal flower structure were found to be more dominant and severe in 35S:PtCLV3 and 35S:PtCLV3-like2 lines than in the 35S:PtCLV3-like line. Disordered vasculature was detected in both stem and hypocotyl cross-sections in Arabidopsis plants over-expressing poplar TDIF-related genes with the most defective vascular patterning observed for TDIF2 and two TDIF-like genes. Phenotypic difference consistently observed in peptide application assay and transgenic analysis indicated the functional diversity of nine poplar PtCLE genes under investigation. This work represents the first report on the functional analysis of CLE genes in a tree species and constitutes a basis for further study of the CLE peptide signalling pathway in tree development. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Identification of cyst nematode B-type CLE peptides and modulation of the vascular stem cell pathway for feeding cell formation.

Directory of Open Access Journals (Sweden)

Xiaoli Guo

2017-02-01

Full Text Available Stem cell pools in the SAM (shoot apical meristem, RAM (root apical meristem and vascular procambium/cambium are regulated by CLE-receptor kinase-WOX signaling modules. Previous data showed that cyst nematode CLE-like effector proteins delivered into host cells through a stylet, act as ligand mimics of plant A-type CLE peptides and are pivotal for successful parasitism. Here we report the identification of a new class of CLE peptides from cyst nematodes with functional similarity to the B-type CLE peptide TDIF (tracheary element differentiation inhibitory factor encoded by the CLE41 and CLE44 genes in Arabidopsis. We further demonstrate that the TDIF-TDR (TDIF receptor-WOX4 pathway, which promotes procambial meristem cell proliferation, is involved in beet cyst nematode Heterodera schachtii parasitism. We observed activation of the TDIF pathway in developing feeding sites, reduced nematode infection in cle41 and tdr-1 wox4-1 mutants, and compromised syncytium size in cle41, tdr-1, wox4-1 and tdr-1 wox4-1 mutants. By qRT-PCR and promoter:GUS analyses, we showed that the expression of WOX4 is decreased in a clv1-101 clv2-101 rpk2-5 mutant, suggesting that WOX4 is a potential downstream target of nematode CLEs. Exogenous treatment with both nematode A-type and B-type CLE peptides induced massive cell proliferation in wild type roots, suggesting that the two types of CLEs may regulate cell proliferation during feeding site formation. These findings highlight an important role of the procambial cell proliferation pathway in cyst nematode feeding site formation.

Comprehensive identification and clustering of CLV3/ESR-related (CLE) genes in plants finds groups with potentially shared function.

Science.gov (United States)

Goad, David M; Zhu, Chuanmei; Kellogg, Elizabeth A

2017-10-01

CLV3/ESR (CLE) proteins are important signaling peptides in plants. The short CLE peptide (12-13 amino acids) is cleaved from a larger pre-propeptide and functions as an extracellular ligand. The CLE family is large and has resisted attempts at classification because the CLE domain is too short for reliable phylogenetic analysis and the pre-propeptide is too variable. We used a model-based search for CLE domains from 57 plant genomes and used the entire pre-propeptide for comprehensive clustering analysis. In total, 1628 CLE genes were identified in land plants, with none recognizable from green algae. These CLEs form 12 groups within which CLE domains are largely conserved and pre-propeptides can be aligned. Most clusters contain sequences from monocots, eudicots and Amborella trichopoda, with sequences from Picea abies, Selaginella moellendorffii and Physcomitrella patens scattered in some clusters. We easily identified previously known clusters involved in vascular differentiation and nodulation. In addition, we found a number of discrete groups whose function remains poorly characterized. Available data indicate that CLE proteins within a cluster are likely to share function, whereas those from different clusters play at least partially different roles. Our analysis provides a foundation for future evolutionary and functional studies. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Simulating wall and corner fire tests on wood products with the OSU room fire model

Science.gov (United States)

H. C. Tran

1994-01-01

This work demonstrates the complexity of modeling wall and corner fires in a compartment. The model chosen for this purpose is the Ohio State University (OSU) room fire model. This model was designed to simulate fire growth on walls in a compartment and therefore lends itself to direct comparison with standard room test results. The model input were bench-scale data...

Decision Making in the Connected Learning Environment (CLE

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Anas Belahcen

2016-03-01

Full Text Available In the last years, we have witnessed to an increasingly heightened awareness of the potential benefits of a challenging and promising educational research area : Adaptive Learning [1]. It has become one of the central technologies in education [2] and was recently named, by Gartner, as the number one strategic technology to impact education in 2015 [3]. In fact, adaptive learning systems become more accessible to educational institutions, corporations, and individuals, however, the challenges encountered are more structural and operational rather than technological [4]. While a lot of research has focused on development and evaluation of technological aspects [5], serious questions remain about the motivation of learners [6],[7] and also the design of the content (or domain model [8],[9] including the learner's autonomy issues [9],[10],[11] and the lack of the learner's control [9],[12],[13]. In order to overcome those challenges, we propose CLE “Connected Learning Environment” which is an ubiquitous learning environment [14] that provide to the learners of this generation a learning environment adapted to their expectations and their lifestyle habits and stimulate also their motivation. As a pedagogical approach, CLE adopts the connectivism [15] and take advantage from its benefits (adaptation to the current technological advances [16], management of learning in communities [17], openness with respect to external resources[18], etc. and adapts this approach in a formal context even though the connectivism was conceived as an informal pedagogical approach [19][20]. CLE introduces a new pedagogical process including four phases detailed later (Knowledge construction, Decision making, Validation, Evaluation and the knowledge construction phase is characterized by the collaboration and communication between heterogeneous communities composed of humans and smart objects [14]. However, the ability to distinguish relevant information among the

hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

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Alicia Pérez-González

Full Text Available hCLE/C14orf166 is a nuclear and cytoplasmic protein that interacts with the RNAP II, modulates nuclear RNA metabolism and is present in cytoplasmic RNA granules involved in localized translation. Here we have studied whether hCLE shares common interactors in the nucleus and the cytosol, which could shed light on its participation in the sequential phases of RNA metabolism. Nuclear and cytoplasmic purified hCLE-associated factors were identified and proteins involved in mRNA metabolism, motor-related proteins, cytoskeletal and translation-related factors were found. Purified hCLE complexes also contain RNAs and as expected some hCLE-interacting proteins (DDX1, HSPC117, FAM98B were found both in the nucleus and the cytoplasm. Moreover, endogenous hCLE fractionates in protein complexes together with DDX1, HSPC117 and FAM98B and silencing of hCLE down-regulates their nuclear and cytosolic accumulation levels. Using a photoactivatable hCLE-GFP protein, nuclear import and export of hCLE was observed indicating that hCLE is a shuttling protein. Interestingly, hCLE nuclear import required active transcription, as did the import of DDX1, HSPC117 and FAM98B proteins. The data indicate that hCLE probably as a complex with DDX1, HSPC117 and FAM98B shuttles between the nucleus and the cytoplasm transporting RNAs suggesting that this complex has a prominent role on nuclear and cytoplasmic RNA fate.

CLE-CLAVATA1 peptide-receptor signaling module regulates the expansion of plant root systems in a nitrogen-dependent manner.

Science.gov (United States)

Araya, Takao; Miyamoto, Mayu; Wibowo, Juliarni; Suzuki, Akinori; Kojima, Soichi; Tsuchiya, Yumiko N; Sawa, Shinichiro; Fukuda, Hiroo; von Wirén, Nicolaus; Takahashi, Hideki

2014-02-04

Morphological plasticity of root systems is critically important for plant survival because it allows plants to optimize their capacity to take up water and nutrients from the soil environment. Here we show that a signaling module composed of nitrogen (N)-responsive CLE (CLAVATA3/ESR-related) peptides and the CLAVATA1 (CLV1) leucine-rich repeat receptor-like kinase is expressed in the root vasculature in Arabidopsis thaliana and plays a crucial role in regulating the expansion of the root system under N-deficient conditions. CLE1, -3, -4, and -7 were induced by N deficiency in roots, predominantly expressed in root pericycle cells, and their overexpression repressed the growth of lateral root primordia and their emergence from the primary root. In contrast, clv1 mutants showed progressive outgrowth of lateral root primordia into lateral roots under N-deficient conditions. The clv1 phenotype was reverted by introducing a CLV1 promoter-driven CLV1:GFP construct producing CLV1:GFP fusion proteins in phloem companion cells of roots. The overaccumulation of CLE2, -3, -4, and -7 in clv1 mutants suggested the amplitude of the CLE peptide signals being feedback-regulated by CLV1. When CLE3 was overexpressed under its own promoter in wild-type plants, the length of lateral roots was negatively correlated with increasing CLE3 mRNA levels; however, this inhibitory action of CLE3 was abrogated in the clv1 mutant background. Our findings identify the N-responsive CLE-CLV1 signaling module as an essential mechanism restrictively controlling the expansion of the lateral root system in N-deficient environments.

La famille Richou : de la meunerie à la banque en Anjou (fin XVIIIe siècle-début XXe siècle

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Claire Steimer

2007-03-01

Full Text Available L'étude de la famille Richou de la fin du XVIIIe siècle au début du XXe siècle en Maine-et-Loire s'appuie sur ses propriétés encore conservées : moulins, fermes, châteaux, hôtels particuliers, banque. L'évocation de certains membres de la famille permet de montrer l'évolution d'une famille bourgeoise au cours du XIXe siècle, marqué par les révolutions agricoles et industrielles. Les Richou se sont ainsi illustrés tout d'abord dans la meunerie, participant activement à la modernisation de cette activité et au développement des minoteries modernes. Ils ont également conforté leur situation avec l'achat de nombreuses terres et la construction ou le réaménagement de fermes répondant aux nouveaux critères productifs et hygiénistes de la 2e moitié du XIXe siècle. Enfin, ils sont à l'origine d'une des premières banques angevines. A travers cette famille, ce sont donc les grands pôles d'activité du XIXe siècle qui sont étudiés (agriculture, industrie, commerce ainsi que leurs témoins architecturaux préservés.This study of the Richou family, from the end of the 18th century up to the beginning of the 20th, is based on the analysis of the family’s properties which still exist in the Maine-et-Loire department: mills, farms, chateaux, town houses and bank. A closer examination of certain members of the family illustrates the evolution of a bourgeois dynasty during the 19th century characterised by its agricultural and industrial revolutions. The Richous first came to the fore as millers, actively participating in the modernisation of milling techniques and constructing modern industrial flourmills. They consolidated their wealth by land purchases and the construction or modernisation of farm buildings corresponding with the new criteria of agricultural production and hygiene during the second half of the 19th century. Finally, the Richous were at the origins of one of the first banking houses in the Anjou region. The

OSU-6: A Highly Efficient, Metal-Free, Heterogeneous Catalyst for the Click Synthesis of 5-Benzyl and 5-Aryl-1H-tetrazoles

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Baskar Nammalwar

2015-12-01

Full Text Available OSU-6, an MCM-41 type hexagonal mesoporous silica with mild Brönsted acid properties, has been used as an efficient, metal-free, heterogeneous catalyst for the click synthesis of 5-benzyl and 5-aryl-1H-tetrazoles from nitriles in DMF at 90 °C. This catalyst offers advantages including ease of operation, milder conditions, high yields, and reusability. Studies are presented that demonstrate the robust nature of the catalyst under the optimized reaction conditions. OSU-6 promotes the 1,3-dipolar addition of azides to nitriles without significant degradation or clogging of the nanoporous structure. The catalyst can be reused up to five times without a significant reduction in yield, and it does not require treatment with acid between reactions.

Measuring marine iron(III) complexes by CLE-AdSV

NARCIS (Netherlands)

Town, R.M.; Leeuwen, van H.P.

2005-01-01

Iron(iii) speciation data, as determined by competitive ligand exchange?adsorptive stripping voltammetry (CLE-AdSV), is reconsidered in the light of the kinetic features of the measurement. The very large stability constants reported for iron(iii) in marine ecosystems are shown to be possibly due to

A study of thermal stratification in the cold legs during the subcooled blowdown phase of a loss of coolant accident in the OSU APEX thermal hydraulic testing facility

International Nuclear Information System (INIS)

Wachs, D. M.

1998-01-01

Thermal stratification, which has been linked to the occurrence of pressurized thermal shock (PTS), is observed to occur during the early stages of simulated loss of coolant accidents (LOCAS) in the Oregon State University Advanced Plant Experiment (OSU APEX) Thermal Hydraulic Test Facility. The OSU APEX Test Facility is a scaled model of the Westinghouse AP600 nuclear power plant. Analysis of the OSU APEX facility data has allowed the determination of an onset criteria for thermal stratification and has provided support for the postulated mechanisms leading to thermal stratification. CFX 4.1, a computational fluid dynamics code, was used to generate a model of the cold legs and the downcomer that described the phenomena occurring within them. Some mixing phenomena were predicted that lead to non-uniformity between the two cold legs attached to the steam generator on the side of the facility containing the Passive Residual Heat Removal (PRHR) injection system. The stratification was found to be two phase and unlikely to be a factor in PTS

Archive of Geosample Data and Information from the Oregon State University (OSU) College of Earth, Ocean and Atmospheric Sciences (CEOAS) Marine Geology Repository (MGR)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Oregon State University Marine Geology Repository (OSU-MGR) is a partner in the Index to Marine and Lacustrine Geological Samples (IMLGS) database, contributing...

La chronologie du royaume de Qatabân du Ier siècle avant J.-C. au Ier siècle après J.-C.

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Mounir Arbach

2002-04-01

Full Text Available Les nouvelles découvertes archéologiques et épigraphiques de ces dernières années, effectuées au cours des fouilles franco-italiennes à Tamna`, l'ancienne capitale du royaume de Qatabân, permettent d'établir une nouvelle chronologie des souverains de Qatabân entre le Ier siècle avant J.-C. et le Ier siècle après J.- C.The chronology of the kingdom of Qatabân, from the 1st century BC to the 1st century AD. Archaeological and epigraphical discoveries made in recent years by the Franco-Italian excavations at Tamna`, the ancient capital of the kingdom of Qatabân, allows us to establish a new chronology for the kings of Qatabân during the 1st century BC and the 1st century AD.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* sialic acid-binding domain of porcine rotavirus strain OSU

International Nuclear Information System (INIS)

Zhang, Yang-De; Li, Hao; Liu, Hui; Pan, Yi-Feng

2007-01-01

Porcine rotavirus strain OSU VP8* domain has been expressed, purified and crystallized. X-ray diffraction data from different crystal forms of the VP8* domain have been collected to 2.65 and 2.2 Å resolution, respectively. The rotavirus outer capsid spike protein VP4 is utilized in the process of rotavirus attachment to and membrane penetration of host cells. VP4 is cleaved by trypsin into two domains: VP8* and VP5*. The VP8* domain is implicated in initial interaction with sialic acid-containing cell-surface carbohydrates and triggers subsequent virus invasion. The VP8* domain from porcine OSU rotavirus was cloned and expressed in Escherichia coli. Different crystal forms (orthorhombic P2 1 2 1 2 1 and tetragonal P4 1 2 1 2) were harvested from two distinct crystallization conditions. Diffraction data have been collected to 2.65 and 2.2 Å resolution and the VP8* 65–224 structure was determined by molecular replacement

CLE peptide-encoding gene families in Medicago truncatula and Lotus japonicus, compared with those of soybean, common bean and Arabidopsis

DEFF Research Database (Denmark)

Hastwell, April H; de Bang, Thomas Christian; Gresshoff, Peter M

2017-01-01

these complete CLE peptide-encoding gene families with those of fellow legumes, Glycine max and Phaseolus vulgaris, in addition to the model plant Arabidopsis thaliana. This approach provided insight into the evolution of CLE peptide families and enabled us to establish putative M. truncatula and L. japonicus...

De l’amour et du mariage. Une correspondance familiale au xixe siècle

OpenAIRE

Dauphin, Cécile; Poublan, Danièle

2013-01-01

L’article se propose d’explorer ce qui est dit du mariage et de l’amour dans la correspondance d’une famille bourgeoise qui couvre plusieurs générations sur un large xixe siècle. Trois épisodes ont été retenus qui permettent d’observer bien des tensions entre mariage arrangé et mariage d’inclination. D’abord, au début du siècle, la correspondance d’un jeune homme à l’aube d’une brillante carrière scientifique explicite les « raisons » sociales et économiques qui déterminent son choix matrimon...

The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study.

Science.gov (United States)

Chasset, François; Arnaud, Laurent; Costedoat-Chalumeau, Nathalie; Zahr, Noel; Bessis, Didier; Francès, Camille

2016-04-01

Up to 30% of patients with cutaneous lupus erythematosus (CLE) fail to respond to hydroxychloroquine (HCQ). We sought to evaluate the efficacy of increased daily doses of HCQ on cutaneous response in refractory CLE. We conducted an open-label prospective study between 2010 and 2014. Patients with CLE and HCQ blood level less than or equal to 750 ng/mL were included. The daily dose of HCQ was increased to reach blood concentrations greater than 750 ng/mL. The primary end point was the number of responders defined by an improvement of CLE Disease Area and Severity Index score (4 points or 20% decrease) in patients with HCQ blood concentration greater than 750 ng/mL. We included 34 patients (26 women; median age 45 [range 28-72] years). Two nonadherent patients were excluded. The median CLE Disease Area and Severity Index score before treatment was significantly improved after treatment (8 [range 2-30] vs 1.5 [range 0-30]), P < .001). The primary response criterion was reached in 26 (81%) of the 32 patients analyzed. A decrease in HCQ doses without further CLE flare (median follow-up 15.8 [range 3.06-77.4] months) was achieved in 15 of the 26 responders. The main limitations of the study are its open-label design and the limited number of patients included. Increasing HCQ doses to reach blood concentrations greater than 750 ng/mL should be considered before addition of other treatments in refractory CLE. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Probe-based confocal laser endomicroscopy (pCLE) - a new imaging technique for in situ localization of spermatozoa.

Science.gov (United States)

Trottmann, Matthias; Stepp, Herbert; Sroka, Ronald; Heide, Michael; Liedl, Bernhard; Reese, Sven; Becker, Armin J; Stief, Christian G; Kölle, Sabine

2015-05-01

In azoospermic patients, spermatozoa are routinely obtained by testicular sperm extraction (TESE). However, success rates of this technique are moderate, because the site of excision of testicular tissue is determined arbitrarily. Therefore the aim of this study was to establish probe-based laser endomicroscopy (pCLE) a noval biomedical imaging technique, which provides the opportunity of non-invasive, real-time visualisation of tissue at histological resolution. Using pCLE we clearly visualized longitudinal and horizontal views of the tubuli seminiferi contorti and localized vital spermatozoa. Obtained images and real-time videos were subsequently compared with confocal laser scanning microscopy (CLSM) of spermatozoa and tissues, respectively. Comparative visualization of single native Confocal laser scanning microscopy (CLSM, left) and probe-based laser endomicroscopy (pCLE, right) using Pro Flex(TM) UltraMini O after staining with acriflavine. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

In-class didactic versus self-directed teaching of the probe-based confocal laser endomicroscopy (pCLE) criteria for Barrett's esophagus.

Science.gov (United States)

Rzouq, Fadi; Vennalaganti, Prashanth; Pakseresht, Kavous; Kanakadandi, Vijay; Parasa, Sravanthi; Mathur, Sharad C; Alsop, Benjamin R; Hornung, Benjamin; Gupta, Neil; Sharma, Prateek

2016-02-01

Optimal teaching methods for disease recognition using probe-based confocal laser endomicroscopy (pCLE) have not been developed. Our aim was to compare in-class didactic teaching vs. self-directed teaching of Barrett's neoplasia diagnosis using pCLE. This randomized controlled trial was conducted at a tertiary academic center. Study participants with no prior pCLE experience were randomized to in-class didactic (group 1) or self-directed teaching groups (group 2). For group 1, an expert conducted a classroom teaching session using standardized educational material. Participants in group 2 were provided with the same material on an audio PowerPoint. After initial training, all participants graded an initial set of 20 pCLE videos and reviewed correct responses with the expert (group 1) or on audio PowerPoint (group 2). Finally, all participants completed interpretations of a further 40 videos. Eighteen trainees (8 medical students, 10 gastroenterology trainees) participated in the study. Overall diagnostic accuracy for neoplasia prediction by pCLE was 77 % (95 % confidence interval [CI] 74.0 % - 79.2 %); of predictions made with high confidence (53 %), the accuracy was 85 % (95 %CI 81.8 % - 87.8 %). The overall accuracy and interobserver agreement was significantly higher in group 1 than in group 2 for all predictions (80.4 % vs. 73 %; P = 0.005) and for high confidence predictions (90 % vs. 80 %; P didactic teaching enables significantly better recognition of the pCLE features of Barrett's esophagus than self-directed teaching. The in-class didactic group had a shorter learning curve and were able to achieve 90 % accuracy for their high confidence predictions. © Georg Thieme Verlag KG Stuttgart · New York.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* sialic acid-binding domain of porcine rotavirus strain OSU

Energy Technology Data Exchange (ETDEWEB)

Zhang, Yang-De, E-mail: zhangyd1960@yahoo.com.cn; Li, Hao [National Hepatobiliary and Enteric Surgery Research Center of The Ministry of Health, Xiangya Hospital, Central South University, Hunan Province (China); Liu, Hui; Pan, Yi-Feng [Biochemistry Laboratory, Institution of Biomedical Engineering, Central South University, Hunan Province (China); National Hepatobiliary and Enteric Surgery Research Center of The Ministry of Health, Xiangya Hospital, Central South University, Hunan Province (China)

2007-02-01

Porcine rotavirus strain OSU VP8* domain has been expressed, purified and crystallized. X-ray diffraction data from different crystal forms of the VP8* domain have been collected to 2.65 and 2.2 Å resolution, respectively. The rotavirus outer capsid spike protein VP4 is utilized in the process of rotavirus attachment to and membrane penetration of host cells. VP4 is cleaved by trypsin into two domains: VP8* and VP5*. The VP8* domain is implicated in initial interaction with sialic acid-containing cell-surface carbohydrates and triggers subsequent virus invasion. The VP8* domain from porcine OSU rotavirus was cloned and expressed in Escherichia coli. Different crystal forms (orthorhombic P2{sub 1}2{sub 1}2{sub 1} and tetragonal P4{sub 1}2{sub 1}2) were harvested from two distinct crystallization conditions. Diffraction data have been collected to 2.65 and 2.2 Å resolution and the VP8*{sub 65–224} structure was determined by molecular replacement.

Sodome à Paris : protohistoire de l’homosexualité masculine fin XVIIIe-milieu XIXe siècle

OpenAIRE

Pastorello, Thierry

2018-01-01

Entre la fin du XVIIIe siècle et jusqu’aux alentours du milieu du XIXe siècle, l’homosexualité masculine, comme catégorie désignant et stigmatisant certains hommes, est en voie de construction. Nous avons pris pour exemple Paris. Ce travail examine ce processus, par un croisement des discours et des vécus. Le cadre parisien offre un laboratoire suffisamment important : les faits d’homosexualité peuvent être observés à travers tout un ensemble de comportements et de pratiques identifiables dan...

Parrains et voisins? Espace et parrainage en banlieue parisienne au XIXe siècle

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Vincent Gourdon

2017-07-01

Full Text Available Située à proximité de Paris, Aubervilliers, au cours du XIXe siècle, connaît une forte croissance de sa population et une transformation de son tissu social avec l’arrivée de migrants et l’orientation des activités économiques vers l’industrie au détriment de l’agriculture traditionnelle. Dans le cadre d’une réfl exion générale concernant la place du parrainage dans la construction des liens sociaux et particulièrement de la sociabilité communautaire à l’échelle locale, la distribution spatiale des parrains et marraines des enfants baptisés dans l’unique église paroissiale de la localité a été analysée sur trois siècles, afi n de montrer la fi n progressive du parrainage entre voisins appartenant à une même communauté, la paroisse, entre XVIIIe siècle et XIXe siècle, et l’élargissement du bassin de recrutement des parents spirituels, celui-ci témoignant du recul de l’esprit communautaire ancien. Au XIXe siècle, quand les choix dans la parenté n’amènent pas à aller quérir des parrains loin d’Aubervilliers, d’autres types de parrains voisins apparaissent: les gens du quartier, voire les voisins d’immeuble, prennent alors une place importante, notamment dans le quartier ouvrier peuplé de migrants de Quatre Chemins-Champ Blanc, au sud de la commune. Il ressort ainsi de l’analyse détaillée des baptêmes de 1881 que l’espace de la banlieue était loin d’être uniforme. Par beaucoup d’aspects dont le parrainage, Aubervilliers était bien une «périphérie» de Paris (cf. la proportion de parrains et marraines vivant dans la capitale, mais en son sein plusieurs quartiers, où des logiques de choix diff érentes étaient mises en oeuvre au moment des baptêmes, coexistaient.

Reply to Comments on Measuring marine iron(III) complexes by CLE-AdSV

NARCIS (Netherlands)

Town, R.M.; Leeuwen, van H.P.

2005-01-01

The interpretation of CLE-AdSV based iron(iii) speciation data for marine waters has been called into question in light of the kinetic features of the measurement. The implications of the re-think may have consequences for understanding iron biogeochemistry and its impact on ecosystem functioning.

La révolution de l'escompte dans la France du XIXe siècle

OpenAIRE

Plessis, Alain

2002-01-01

Dans la France du xixe siècle, ceux qui voulaient faire des échanges se heurtaient à un double problème : pouvoir régler leurs paiements sur une place éloignée de leur domicile et trouver des crédits abondants à court terme. Les effets de commerce, qui sont à la fois des instruments de règlement et la « matière première » de l’escompte, pouvaient permettre de résoudre cette double difficulté. Depuis le XVIIIe siècle l’escompte des effets de commerce est une pratique connue en France. Mais jus...

La sauvegarde des grandes oeuvres de l'ingénierie du XXème siècle

CERN Document Server

Graf, Franz

2016-01-01

Consacré à la sauvegarde des grandes oeuvres de l’ingénierie du XXe siècle, ce premier numéro des Cahiers du TSAM explore le devenir de certaines des plus remarquables et emblématiques structures en béton du siècle passé. A travers les fi gures d’héroïques constructeurs, il interroge l’héritage construit des ingénieurs, convoquant les plus audacieux d’entre eux (Freyssinet, Isler, Maillart, Nervi, Vierendeel, etc.). Alors que la sauvegarde de l’architecture du XXe siècle s’est récemment constituée en discipline à part entière, la préservation des ouvrages de l’ingénierie de cette période est encore balbutiante. Considérés trop souvent sous le seul point de vue de la sécurité ou de la maintenance, ces ouvrages s’avèrent parfois de véritables chefs-d’oeuvre, jalons d’un «art de l’ingénieur» à la frontière entre performance technique et beauté plastique. Ces cahiers sont donc l’occasion d’initier, à l’appui d’exemples et de projets de sauvegarde con...

Scènes de plage dans la peinture hollandaise du XVIIe siècle: l'entrée de la plage dans l'espace des citadins

Directory of Open Access Journals (Sweden)

Rémy Knafou

2000-06-01

Full Text Available Les scènes de plage sont une catégorie de la peinture hollandaise, inventée au XVIIe siècle. L'analyse d'un corpus de tableaux peints durant le Siècle d’Or permet de montrer que le «désir de rivage» analysé par Alain Corbin est apparu sur le littoral de la mer du Nord dès le XVIIe siècle avec l'ouverture de la plage aux citadins oisifs venus des villes voisines.

Resenha de: Le XVIe siècle européen: aspects économiques

Directory of Open Access Journals (Sweden)

Eurípedes Simões de Paula

1967-03-01

Full Text Available MAURO (Frédéric . — Le XVIe siècle européen. Aspects économiques. Paris. Presses Universitaires de France. Coleção "Nouvelle Clio". 1 volume de 13,5 x 18 cm. 392 páginas, 14 mapas e gráficos.

Sodome à Paris : protohistoire de l’homosexualité masculine, fin XVIII– milieu XIXe siècle

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Thierry Pastorello

2009-07-01

Full Text Available Alain Corbin, dans une étude intitulée L’Harmonie des plaisirs : les manières de jouir du siècle des lumières à l’avènement de la sexologie, note en ce qui concerne la période étudiée l’obligation d’oublier les concepts forgés par la sexologie. Pourtant, si la construction de l’homosexualité ne peut être envisagée avant la fin du XIXe siècle, les sentiments dits homosexuels furent antérieurement perçus à travers certains critères. Les hommes pratiquant ces rapports affectifs et sexuels eurent...

Mild Microcytic Anemia in an Infant with a Compound Heterozygosity for Hb C (HBB: c.19G > A) and Hb Osu Christiansborg (HBB: c.157G > A).

Science.gov (United States)

Boucher, Maria O; Chui, David H K; Woda, Bruce A; Newburger, Peter E

2016-06-01

We report an infant with a compound heterozygosity for Hb C (HBB: c.19G > A) and Hb Osu Christiansborg (HBB: c.157G > A) and a phenotype of mild microcytic anemia with target cell morphology but without overt hemolysis.

Bringing a Global Issue Closer to Home: The OSU Climate Change Webinar Series

Science.gov (United States)

Jentes Banicki, J.; Dierkes, C.

2012-12-01

When people think about the effects of climate change, many will still picture that iconic lone polar bear clinging to a shrinking iceberg in Antarctica. But many don't realize that the impacts that we will face here at home could also be severe, directly affecting the food we eat, the health we have, and the natural environments we appreciate. To help better explain and ultimately localize those impacts for Great Lakes residents, 10 departments within Ohio State University partnered in 2009 to create the Global Change, Local Impact webinar series. The monthly series brings in experts from around the Great Lakes region to discuss issues and impacts we will encounter regionally as our climate changes. Originally designed as a small series for Ohioans, the series has broadened to focus on Great Lakes-related issues, with more than 4,500 attendees representing 500 organizations in governmental agencies, academia, non-profit groups, private industry, and the legislature from around the country. Over the past two years, the OSU Climate Team expanded its educational reach by partnering with external groups like the Centers for Disease Control and Prevention, Great Lakes Regional Water Program, National Oceanic and Atmospheric Administration, and the Great Lakes Sea Grant Network to help deliver the most knowledgeable experts and resources for each Great Lake-focused climate topic and archive those resources on its www.changingclimate.osu.edu web site. As a result of these collaborative efforts, participants say the webinars are one of their primary resources for climate-related research information in the region, with 80-90% polled saying they use this information as an unbiased resource to help not only understand how climate change could affect local concerns like public health, agriculture, and infrastructure, but what they in their vocations and daily lives can do to prepare for it. For scientists and practitioners, this series serves as the perfect low carbon venue

Shakespeare dans le Brésil du 19e siècle : un exemple de transfert culturel

OpenAIRE

Segurado, Livia

2015-01-01

Partant de l’Angleterre vers l’Europe continentale au 18ème siècle, les pièces de Shakespeare arrivent au Brésil au 19ème siècle via des modèles français. Ce transfert culturel se fait d’abord par la perception de la culture étrangère imposée au Brésil lors de sa colonisation, suivie d’une graduelle interaction avec elle, puis d’une réinvention adaptée à la couleur locale. L’acteur João Caetano débute en 1835 une approche plus nationaliste, mais c’est la littérature qui voit surgir un authent...

Resenha de: L'Europe et le monde à la fin du XVIIIe siècle

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Eurípedes Simões de Paula

2017-04-01

Full Text Available DEVÉZE (Michel. — L'Europe et le monde à la fin du XVIIIe siècle. Coleção "L'Évolution de l'Humanité". Éditions Albin Michel. Paris. 1971. 703 pp., 7 mapas. Preço 12,00 F.

Saccharification of recalcitrant biomass and integration options for lignocellulosic sugars from Catchlight Energy's sugar process (CLE Sugar).

Science.gov (United States)

Gao, Johnway; Anderson, Dwight; Levie, Benjamin

2013-01-28

Woody biomass is one of the most abundant biomass feedstocks, besides agriculture residuals in the United States. The sustainable harvest residuals and thinnings alone are estimated at about 75 million tons/year. These forest residuals and thinnings could produce the equivalent of 5 billion gallons of lignocellulosic ethanol annually. Softwood biomass is the most recalcitrant biomass in pretreatment before an enzymatic hydrolysis. To utilize the most recalcitrant lignocellulosic materials, an efficient, industrially scalable and cost effective pretreatment method is needed. Obtaining a high yield of sugar from recalcitrant biomass generally requires a high severity of pretreatment with aggressive chemistry, followed by extensive conditioning, and large doses of enzymes. Catchlight Energy's Sugar process, CLE Sugar, uses a low intensity, high throughput variation of bisulfite pulping to pretreat recalcitrant biomass, such as softwood forest residuals. By leveraging well-proven bisulfite technology and the rapid progress of enzyme suppliers, CLE Sugar can achieve a high yield of total biomass carbohydrate conversion to monomeric lignocellulosic sugars. For example, 85.8% of biomass carbohydrates are saccharified for un-debarked Loblolly pine chips (softwood), and 94.0% for debarked maple chips (hardwood). Furan compound formation was 1.29% of biomass feedstock for Loblolly pine and 1.10% for maple. At 17% solids hydrolysis of pretreated softwood, an enzyme dose of 0.075 g Sigma enzyme mixture/g dry pretreated (unwashed) biomass was needed to achieve 8.1% total sugar titer in the hydrolysate and an overall prehydrolysate liquor plus enzymatic hydrolysis conversion yield of 76.6%. At a much lower enzyme dosage of 0.044 g CTec2 enzyme product/g dry (unwashed) pretreated softwood, hydrolysis at 17% solids achieved 9.2% total sugar titer in the hydrolysate with an overall sugar yield of 85.0% in the combined prehydrolysate liquor and enzymatic hydrolysate. CLE Sugar has

Au xxe siècle, la subjectivité des sciences

OpenAIRE

Andrieu, Bernard

2005-01-01

Le xxe siècle aura invalidé définitivement l’objectivité des sciences. Plutôt que de reprocher aux sciences humaines un usage analogique des modèles de légitimation de ce qui serait l’objectivité scientifique  de la nature, il faudrait situer la subjectivité contemporaine des sciences de la nature et de la vie. La relativité, qui a pu mener au relativisme, aura introduit les sciences dans l’historicité et dans la falsifiabilité plutôt que dans la vérité éternelle. Nous nous proposons ici de d...

Cleófilas and La Llorona: Latin Heroines Against Patriarchal Marginalisation in ‘El arroyo de la Llorona’, a Short Story by Sandra Cisneros

OpenAIRE

Luis fernando Gómez R

2012-01-01

This paper discusses the short story ‘El arroyo de la Llorona’ by female Mexican-American writer Sandra Cisneros. In it the main character, Cleófilas, is subject to social, emotional and economic dependence on her husband, according to the cultural constructs on female identity that are still relevant in Latin-American patriarchal societies. Due to her circumstances of complete marginalisation and domestic violence, Cleófilas chooses to avoid reality, and this avoidance not only costs her men...

La compagnie Scarampi et les Italiens de Meaux au XIVe siècle

OpenAIRE

Wilmart, Mickaël

2004-01-01

L'article propose l'étude d'une compagnie marchande italienne installée à Meaux (Seine-et-Marne) à la fin du XIIIe siècle et qui développe ses activités financières et commerciales dans le cadre des foires de Champagne. Originaire d'Asti, les Scarampi quittent leur ville pour des raisons politiques et s'affirment rapidement comme une des plus grosses fortunes de Meaux.

Cleófilas and La Llorona: Latin Heroines Against Patriarchal Marginalisation in ‘El arroyo de la Llorona’, a Short Story by Sandra Cisneros

Directory of Open Access Journals (Sweden)

Luis fernando Gómez R

2012-08-01

Full Text Available This paper discusses the short story ‘El arroyo de la Llorona’ by female Mexican-American writer Sandra Cisneros. In it the main character, Cleófilas, is subject to social, emotional and economic dependence on her husband, according to the cultural constructs on female identity that are still relevant in Latin-American patriarchal societies. Due to her circumstances of complete marginalisation and domestic violence, Cleófilas chooses to avoid reality, and this avoidance not only costs her mental well-being,but also annuls her will to make changes to her suffocating life. Oppressed by a patriarchal system,Cleófilas develops an unusual interest in the Llorona legend and, through the remembrance of this myth, these two female figures become symbols of resistance and liberation. In the story, the Llorona ceases to be the denigrated woman tradition has always made her out to be, and becomes the image of a contemporary heroine capable of challenging radical patriarchal norms.

Resenha de: La vie de la forêt française au XIVè siècle

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Eurípedes Simões de Paula

1963-03-01

Full Text Available DEVÈZE (M.. La vie de Ia forêt française au XIVe siècle. Paris. S. E. V. P. E. N. École Pratique des Hautes Études. Centre de Recharches historiques. VIe section. Coleção "Les hom-mes et la terre". Tomos I e II.

Élisabeth BADINTER, Mme du Châtelet, Mme d’Épinay ou l’ambition féminine au XVIIIe siècle

OpenAIRE

Duprat, Annie

2009-01-01

Cet ouvrage est la réédition, un peu transformée et augmentée, d’un livre qu’Élisabeth Badinter avait consacré en 1983 à ces deux femmes savantes du siècle des Lumières, Emilie du Châtelet et Louise d’Épinay, sous le titre Émilie, Emilie, l’ambition féminine au XVIIIe siècle. Ce titre un peu obscur devait attirer l’attention sur les similitudes (de destin, de vie, de comportement et d’intérêts scientifiques entre les deux femmes, Louise d’Épinay se faisant appeler Émilie pour plaire à son ama...

"Palabras de la Ciencia": Pedro Castera and Scientific Writing in Mexico's "Fin de Siècle"

Science.gov (United States)

del Pilar Blanco, María

2014-01-01

This essay explores the career of the understudied writer Pedro Castera (1846-1906), who is regarded as one of the first practitioners of science fiction in Mexico. A man of many talents, Castera is one of the most eccentric and eclectic figures in the intellectual life of fin-de-siècle Mexico City. His career took many turns: While during…

Musical Dandysme: Aestheticism and Orientalism in fin-de-si�cle France

OpenAIRE

Ersoff, Zarah

2013-01-01

This dissertation explores some of the ways in which fin-de-si�cle French composers negotiated the boundaries between masculinity, aestheticism and Orientalism in their music. Dandysme - in English, dandyism - refers to the philosophy and practices of the dandy, an individual (usually male) who places particular importance upon physical appearance and mannered elegance, who lives his life with an air of cold indifference, and above all, according to Charles Baudelaire, strives to elevate ae...

Christian Delporte, Image et politique en France au XXe siècle

OpenAIRE

Kéita, Sékouna

2013-01-01

Dans cet ouvrage, l’auteur revient sur le rôle de l’image en tant qu’outil de communication mais aussi comme instrument de persuasion et de manipulation politique. Il s’agit d’une réflexion approfondie sur les fonctions politiques des documents visuels (image télévisuelle, cinéma, photographie, dessin et caricature etc.) dans leur évolution à travers le xxe siècle. Une évolution du traitement et du rôle de l’image parallèle aux progrès techniques et technologiques de la société. L’image conna...

SparCLeS: dynamic l₁ sparse classifiers with level sets for robust beard/moustache detection and segmentation.

Science.gov (United States)

Le, T Hoang Ngan; Luu, Khoa; Savvides, Marios

2013-08-01

Robust facial hair detection and segmentation is a highly valued soft biometric attribute for carrying out forensic facial analysis. In this paper, we propose a novel and fully automatic system, called SparCLeS, for beard/moustache detection and segmentation in challenging facial images. SparCLeS uses the multiscale self-quotient (MSQ) algorithm to preprocess facial images and deal with illumination variation. Histogram of oriented gradients (HOG) features are extracted from the preprocessed images and a dynamic sparse classifier is built using these features to classify a facial region as either containing skin or facial hair. A level set based approach, which makes use of the advantages of both global and local information, is then used to segment the regions of a face containing facial hair. Experimental results demonstrate the effectiveness of our proposed system in detecting and segmenting facial hair regions in images drawn from three databases, i.e., the NIST Multiple Biometric Grand Challenge (MBGC) still face database, the NIST Color Facial Recognition Technology FERET database, and the Labeled Faces in the Wild (LFW) database.

Konverze a rekonverze Emanuela Haunera v období fin de siècle

OpenAIRE

Semsch, Alžběta

2013-01-01

The goal of the final thesis Emanuel Hauner's conversion and reconversion at the fin de siècle is to introduce and to interpret Emanuel Hauner's major poetic works, which have been so far neglected by the Czech literary history. My goal was to analyze the reasons of refusal of his works by both readers and critics. To make this analysis precise, it was necessary to take a close look at two phenomena appearing in Hauner's work: stylization and epigonism. The second major goal of this thesis wa...

Dual roles for the variable domain in protein trafficking and host-specific recognition of Heterodera glycines CLE effector proteins

Science.gov (United States)

Soybean cyst nematodes (Heterodera glycines) produce secreted effector proteins that function as peptide mimics of plant CLAVATA3 / ESR (CLE)-like peptides probably involved in the developmental reprogramming of root cells to form specialized feeding cells called syncytia. The site of action and me...

Cle Elum and Supplementation Research Facility : Monthly Progress Report October 2008.

Energy Technology Data Exchange (ETDEWEB)

Cle Elum Supplementation and Research Facility

2008-12-11

FISH PRODUCTION: On October 7th the 2008 spawning season was completed. 823 adults were transferred to the facility for the 2008 season. The overall adult mortality was 6.9% (1.3% pre-spawning mortality and 5.6% encountered after sorting). Wild/natural salmon collected included 278 females, 173 males, and 29 jacks for a total 480 fish for the 2008 brood. Supplemented brood stock collected included 149 adults (85 females, 35 males and 29 jacks). Hatchery control brood collected for research included 194 adults (91 females, 68 males and 35 jacks). Eggs will be inventoried in November with an actual summary of eggs numbers to be submitted for the November report. The estimated egg takes (production) for the 2008 season was 1,375,146 eggs with 1,006,063 comprising of W x W crosses and 250,755 eggs of H x H crosses with 118,328 supplement crosses. Total fish on hand for the 2007 brood is 768,751 with an average fish per pound of 30.6 f/lb. FISH CULTURE: The marking and pit-tagging operation started on October 13th. The pit-tagging portion was completed on October 23rd. A total 40,000 juveniles were pit-tagged (2,000 from each of the production ponds and 4,000 each for the hatchery juvenile ponds 9 & 10). Cle Elum staff began shocking, sorting, counting and splitting eggs in incubation. Shocking eggs will separate live eggs from dead eggs. Eggs are treated with formalin three times a week to control fungus. The focus for the culturists during the month of October entail completing the final spawn (egg take) on the 7th, pond cleaning, keeping the marking trailers supplied with fish and end of month sampling. The adult holding ponds were power washed and winterized for the shut down period. Facility crew members Greg Strom and Mike Whitefoot assisted Joe Blodgett and his crew with fish brood collection on the 22nd of October. Fall Chinook and Coho salmon were seined up and put in tanker trucks from Chandler canal and transported to holding ponds for later spawning. Charlie

Identification of cyst nematode B-type CLE peptides and modulation of the vascular stem cell pathway for feeding cell formation

Science.gov (United States)

Stem cells are important in the continuous formation of various tissues during postembryonic organogenesis. Stem cell pools in the SAM (shoot apical meristem), RAM (root apical meristem) and vascular procambium/cambium are regulated by CLE-receptor kinase-WOX signaling modules. Previous data showed ...

Une petite histoire du motif du repas au xixe siècle

OpenAIRE

Sicotte, Geneviève

2012-01-01

Au xixe siècle en France, on discute abondamment et avec passion de la nourriture dans un ensemble de textes extrêmement divers : écrits gastronomiques, revues spécialisées, manuels de savoir-vivre, livres de cuisine, traités d’hygiène alimentaire, publicités pour restaurants, chroniques de la presse boulevardière, poèmes, romans, essais. Le thème alimentaire, en quelques décennies, se trouve légitimé et encouragé par une bourgeoisie en plein essor, désireuse de créer de nouveaux usages et de...

Le vol sous l’œil des médecins légistes. Étude du concept de kleptomanie au cours du XIXe siècle

OpenAIRE

Bogani, Lisa

2016-01-01

Introduit en 1816 par le Dr Matthey, le concept de kleptomanie connait de multiples évolutions au cours du long xixe siècle. Alors qu’il parvient difficilement à se faire reconnaître des magistrats et des aliénistes du premier xixe siècle, il réussit finalement à se maintenir et à s’assoir solidement dans les prétoires de la iiie République. Entre temps, ses caractéristiques évoluent sensiblement en raison des nouvelles découvertes cliniques de l’aliénation mentale et de l’apparition de la fi...

Le Téméraire des Allemands : la perception de Charles le Téméraire dans l’espace allemand au XVe siècle

OpenAIRE

Dubray, Julien

2017-01-01

Nous chercherons dans ce travail à étudier la perception de Charles le Téméraire dans l’Empire à la fin du XV e siècle. Notre enquête se limitera aux régions de langue allemande. Pour ce faire, nous emploierons des sources diplomatiques, ainsi que des sources littéraires, tels que les poèmes et les lieder qui circulèrent du vivant du duc. Notre source principale consistera cependant en un corpus de chroniques réalisées entre la mort de Charles en 1477 et les premières années du XVI e siècle e...

Recherches sur l’apocalyptique syriaque et byzantine au viie siècle : la place de l’Empire romain dans une histoire du salut

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Pablo Ubierna

2009-02-01

Full Text Available L’occupation perse et la littérature apocalyptiqueLa perception des événements militaires du début du viie siècle – d’abord l’occupation perse et ensuite la guerre arabe – n’est pas écartée, chez les contemporains, de la vision d’un empire, l’empire byzantin, secoué par de fortes controverses religieuses.La préoccupation intellectuelle à propos de la situation de l’Empire fut extrêmement marquée au commencement du viie siècle. Une vie anonyme de l’empereur Maurice inclut un récit de sa mort d...

Les voies de l’américanisation: espace américain et écriture de l’histoire au XVIe siècle

OpenAIRE

Gruzinski, Serge

2013-01-01

Si depuis la Renaissance l’écriture de l’histoire s’est développée sous diverses modalités dans la chrétienté latine, elle s’est métamorphosée en s’installant sur le sol américain. Alors que la discipline européenne est censée adopter ses contours « modernes » dans l’Italie du XVe siècle avec Leonardo Bruni et Flavio Biondo et qu’elle acquiert sa vitesse de croisière dans la première moitié du siècle suivant dans le sillage des Machiavel et des Guichardin, l’histoire que l’on écrit sur le sol...

Une carte du bon chemin: géographie, rhétorique et religion au XIXe siècle

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Laurent GRISON

1997-09-01

Full Text Available L'analyse d'une carte du milieu du XIXe siècle nous montre comment le langage géographique peut être associé à un ensemble allégorique et symbolique pour devenir le support rhétorique d'un message moral et religieux. La géographie se veut alors «philosophie».

Les réseaux d’investissement dans le thermalisme au XIXe siècle en France

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Jérôme Penez

2004-03-01

Full Text Available Le XIXe siècle est le siècle de la « fièvre thermale » en France. Pour permettre cet extraordinaire développement, l’argent est nécessaire. La station thermale apparaît comme un eldorado où la fortune est à portée de la main. Cette fortune n’est pourtant pas si facile à obtenir, la gestion thermale est ingrate, et les centaines de villes d’eaux françaises ne peuvent pas toutes obtenir un succès comparable à celui de Vichy ou d’Aix-les-Bains. Le thermalisme français est diversité, diversité dans les réussites, diversité dans les types de gestion (de la gestion étatique à la gestion privée, diversité dans sa fréquentation, diversité dans ses périodes de développement, diversité dans les moyens de son financement. Etudier l’importance ou au contraire la rareté des réseaux d’investissement dans le thermalisme permet de lever une partie du voile de l’histoire encore bien mystérieuse des villes d’eaux françaises.

"Palabras de la ciencia": Pedro Castera and Scientific Writing in Mexico's Fin de Siècle

Science.gov (United States)

Blanco, María del Pilar

2014-03-01

This essay explores the career of the understudied writer Pedro Castera (1846-1906), who is regarded as one of the first practitioners of science fiction in Mexico. A man of many talents, Castera is one of the most eccentric and eclectic figures in the intellectual life of fin-de-siècle Mexico City. His career took many turns: While during specific periods he devoted himself to writing and participating within the liberal, cosmopolitan culture of Mexico City, he often disappeared from the public eye to devote himself to the development of inventions in the mining industry. The essay discusses the different meanings of `invention' within Castera's oeuvre, namely poetic and scientific innovation. Setting these two concepts within the domains of literature and scientific writing in the global and local fin de siècle, the essay investigates how Castera's journalism and fiction (specifically his 1890 novel Querens) are representative of the wider question of scientific development in Mexico and Latin America as a whole during the nineteenth century. Furthermore, it explores the intersections of aesthetics and science during a critical period of modern intellectual history, in which these two areas of knowledge were gradually defining themselves as two distinctive cultures.

Nicolas Lyon-Caen , La boîte à Perrette, le jansénisme parisien au xviiie siècle

OpenAIRE

Vermander, Benoît

2012-01-01

Nicolas Lyon-­­­Caen publie ici sa thèse sou­­te­­nue en 2008 à l’uni­­ver­­sité Paris I (dir. Cl. Mi­­­chaud) sous le titre Mar­­chands de miracles. La bour­­geoi­­sie jan­­sé­­niste pari­­sienne au xviiie siècle, elle-­­­même pro­­lon­­ge­­ment d’une thèse de l’École des Chartes consa­­crée au finan­­ce­­ment du « parti » jan­­sé­­niste au xviiie siècle (La boîte à Perrette, 2002). Ce n’est donc pas une his­­toire de l’ensemble des jan­­sé­­nistes pari­­siens que l’on trou­­vera dans cet ou...

Iconografie del melodrammatico fin de siècle: Salomé di Wilde/Beardsley e La signorina Else di Schnitzler/Fior

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Beatrice Seligardi

2017-11-01

Full Text Available The article aims at comparing two works that show a melodramatic representation of the fin de siècle woman: the tragic drama Salome written by Oscar Wilde and illustrated by Aubrey Beardsley and the graphic novel La signorina Else by Manuele Fior based on Schnitzler's novel.

In planta processing and glycosylation of a nematode CLE effector and its interaction with a CLV2-like receptor to promote parasitism

Science.gov (United States)

Like other biotrophic plant pathogens, plant-parasitic nematodes secrete effector proteins into host cells to facilitate infection. Effector proteins that mimic plant CLAVATA3/ESR (CLE)-like proteins have been identified in several cyst nematodes including the potato cyst nematode (PCN); however, th...

Evaluation of cholera surveillance system in Osu Klottey District, Accra, Ghana (2011-2013).

Science.gov (United States)

Adjei, Eric Yirenkyi; Malm, Keziah Laurencia; Mensah, Kofi Nyarko; Sackey, Samuel Oko; Ameme, Donne; Kenu, Ernest; Abdulai, Marijanatu; Mills, Richael; Afari, Edwin

2017-01-01

Cholera is an acute illness characterized by profuse watery diarrhea. It is caused by vibrio cholera subgroup 01 and 0139. Rapid administration of fluid replacement therapy and supportive treatment can reduce mortality to around 1%. By the close of 2011, 10,628 cases and 100 deaths were reported in Ghana with a case fatality rate of 0.99. It is important to evaluate the cholera surveillance system in Ghana to determine if it is meeting its objective. The study was conducted in Osu Klottey district in the Accra Metropolitan area in January 2014. We assessed the operations (attributes and performance) of the surveillance system for cholera using CDC guidelines (2001). Surveillance data records at the district level from 2011-2013 were extracted and analyzed for frequency using Microsoft excel. Stakeholders and key informants were interviewed using structured questionnaire. Records were also reviewed at some health facilities and at district levels. In 2011 and 2012, case fatality rates (1.3% and 0.65%) respectively. Males were mostly affected. The most affected age group was 20-29. In 2011, Predictive value positive was 69.2% and 50% in 2012.Cholera peaked in March 2011 and April 2012. The Government of Ghana funded the system. The system is sensitive, simple, stable, flexible, acceptable and representative. It was also useful and data quality was relatively good. Predictive Value Positive was also good. The surveillance system is achieving its set out objectives. The system is sensitive, simple, stable, flexible, and acceptable. Predictive value positive was good.

Le stéréotype du bandit catalan dans la littérature espagnole du Siècle d’Or

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Mathias Ledroit

2009-12-01

Full Text Available Le bandit catalan est un personnage que l’on rencontre fréquemment dans la littérature espagnole du Siècle d’Or et des auteurs tels que Cervantès, Lope de Vega et Tirso de Molina se sont beaucoup intéressés à lui à une époque où le banditisme resurgit avec force en Espagne. Le poncif littéraire présente de nombreux points communs avec le stéréotype social tel qu’il est représenté dans les documents contemporains qui exposent les origines du phénomène. Il est dans les deux cas dépeint comme un justicier qui n’écoute que ce que lui dicte son honneur. Toutefois, il s’agit d’une vision déformée de la réalité qui pose un problème d’interprétation : comment expliquer que les auteurs espagnols du XVIIe siècle aient pu voir dans ce criminel un modèle de vertu ?

Christophe Couderc, dir., Le théâtre Espagnol du Siècle d'Or en France. De la traduction au transfert culturel

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Christian Andrès

2012-12-01

Full Text Available Review of Christophe Couderc, Le théâtre Espagnol du Siècle d'Or en France. De la traduction au transfert culturel, Presses Universitaires de Paris Ouest, París, 2012, 299 pp. ISBN: 978-2-84016-102-8.

Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions

Energy Technology Data Exchange (ETDEWEB)

Li, Zhijie; Chakraborty, Sayan; Xu, Guozhou; Kobe, Bostjan

2017-04-06

Tracheary Element Differentiation Inhibitory Factor (TDIF) belongs to the family of post-translationally modified CLE (CLAVATA3/embryo surrounding region (ESR)-related) peptide hormones that control root growth and define the delicate balance between stem cell proliferation and differentiation in SAM (shoot apical meristem) or RAM (root apical meristem). In Arabidopsis, Tracheary Element Differentiation Inhibitory Factor Receptor (TDR) and its ligand TDIF signaling pathway is involved in the regulation of procambial cell proliferation and inhibiting its differentiation into xylem cells. Here we present the crystal structures of the extracellular domains (ECD) of TDR alone and in complex with its ligand TDIF resolved at 2.65 Åand 2.75 Å respectively. These structures provide insights about the ligand perception and specific interactions between the CLE peptides and their cognate receptors. Our in vitro biochemical studies indicate that the interactions between the ligands and the receptors at the C-terminal anchoring site provide conserved binding. While the binding interactions occurring at the N-terminal anchoring site dictate differential binding specificities between different ligands and receptors. Our studies will open different unknown avenues of TDR-TDIF signaling pathways that will enhance our knowledge in this field highlighting the receptor ligand interaction, receptor activation, signaling network, modes of action and will serve as a structure function relationship model between the ligand and the receptor for various similar leucine-rich repeat receptor-like kinases (LRR-RLKs).

Quelques remarques sur le nomadisme préhilalien au Maghreb (viiie-xie siècle)

OpenAIRE

Benhima, Yassir

2011-01-01

Cette étude propose un aperçu de l'histoire du nomadisme au Maghreb avant le début des migrations hilaliennes au milieu du xie siècle. Ce sujet demeure peu étudié en comparaison avec le nomadisme en Afrique du Nord à l'époque antique, dont la connaissance a connu récemment un grand développement. L'examen des sources arabes du haut Moyen Âge permet de constater la diversité des termes employés pour désigner les populations nomades et leur mode de vie. Les aspects résidentiels, territoriaux et...

What was uniform about the fin-de-siècle sailor suit?

Science.gov (United States)

Rose, Clare

2011-01-01

The sailor suits widely worn by children in late-nineteenth-century Britain have been interpreted at the time, and since, as expressions of an Imperial ethos. Yet, a closer examination of the ways that these garments were produced by mass manufacturers, mediated by advertisers and fashion advisors and consumed by families makes us question this characterization. Manufacturers interpreted sailor suits not as unchanging uniforms but as fashion items responding to seasonal changes. Consumers used them to assert social identities and social distinctions, selecting from the multiple variants available. Cultural commentators described sailor suits as emulating Royal practice—but also as ‘common’ and to be avoided. A close analysis of large samples of images and texts from the period 1870–1900 reveals how these different meanings overlapped, making the fin-de-siècle sailor suit a garment that undermines many of our assumptions.

Au prisme de l’altérité, les orthodoxes de Beyrouth au début du xix esiècle

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May Davie

2012-01-01

Full Text Available La construction sociale des orthodoxes de Beyrouth, au début du xixe siècle, s’effectue autant dans le cadre de la communauté qu’à travers un réseau de relations et d’obligations économiques et sociales extérieures. Cet article, par une approche d’histoire urbaine, contredit les thèses du cloisonnement confessionnel.

Notarum figura : l’écriture musicale et le monde des signes au IXe siècle

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Eduardo Henrik Aubert

2010-10-01

Full Text Available Quand l’auteur (ou les auteurs du traité De musica disciplina employèrent l’expression notarum figura pour parler de l’écriture musicale au milieu du IXe siècle, il a placé la notation dans le domaine d’une pluralité de marques écrites qui étaient aussi nommées notae : les signes prosodiques, les signes de ponctuation, parmi plusieurs autres. En faisant appel au mot figura dans la même expression – et aussi à forma –, le champ a été élargi davantage et l’écriture musicale a ainsi été potenti...

Micenas na Viena fin-de-siècle: Nietzsche, Freud, Hofmannsthal e o eterno retorno do mito

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Leonardo Munk

2012-12-01

Full Text Available Este artigo tem por objetivo investigar a correlação de pensamento entre três importantes nomes da segunda metade do século XIX - Friedrich Nietzsche, Sigmund Freud e Hugo von Hofmannsthal - que se debruçaram sobre as crises da identidade masculina frente ao retorno do matriarcado. Tendo a Viena fin-de-siècle como cenário, o feminino é apresentado aqui por intermédio de Electra, que no texto homônimo de Hofmannsthal representa não só o fortalecimento como a própria destruição da mulher.

What Are You Looking at? The Complication of the Male Gaze in "Fin de Siècle" Cancan and Bob Fosse's "Sweet Charity"

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Calvano, Jenn Ariadne

2018-01-01

"Fin de siècle" cancan dancers Jane Avril and Louise Weber ("La Goulue") examined alongside the musical dance and song number "Big Spender" from Sweet Charity serve as examples of how decontextualization of images leads to essentializing the subject of the image that gives precedence to a male gaze focus. In analyzing…

Le mythe de Narcisse dans la littérature « fin de siècle » : autour des limites de l’intertextualité // The myth of Narcissus in French literature "fin de siècle" issue of boundaries of intertextuality

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Magdalena Kučerová

2015-12-01

Full Text Available The author of the article deals with specific features of literary myth concerning intertextuality, and mainly the issue of identification of hypotext in literary texts rewriting the mythological narrative. Providing works of the three writers as an example — André Gide, Jean Lorrain, Paul Valéry — the author points out the French literature tendency « fin de siècle » to ambiguous oscillation between the creation of the myth itself and its interpretation beyond the scope of one comprehensive artistic discourse.

Analysis of two potential long-distance signaling molecules, LjCLE-RS1/2 and jasmonic acid, in a hypernodulating mutant too much love.

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Magori, Shimpei; Kawaguchi, Masayoshi

2010-04-01

Legume plants tightly control the number and development of root nodules. This is partly regulated by a long-distance signaling known as auto-regulation of nodulation (AON). AON signaling involves at least two potential long-distance signals: root-derived signal and shoot-derived signal. However, their molecular characteristics and the mode of action remain unclear. In our recent study, we isolated a novel Lotus japonicus hypernodulating mutant too much love (tml). Based on several grafting experiments, we concluded that its causative gene TML functions as a receptor of the shoot-derived signal. This finding prompted us to ask how the candidates of the long-distance signal molecules, LjCLE-RS1/2 and jasmonic acid (JA), are affected in tml mutants. Expression analysis revealed that rapid induction of LjCLE-RS1/2 upon rhizobial inoculation is still intact in tml, supporting that TML plays a role in reception of the shoot-derived signal but not in generation of the root-derived signal. Furthermore, physiological analysis showed that JA, a candidate of the shoot-derived signal, can suppress tml hypernodulation. Therefore, contrary to the previous report, JA might not be a component of AON signaling.

Un diplomate dans le siècle souvenirs et anecdotes

CERN Document Server

de Rose, François

2014-01-01

Diplomate français, François de Rose a connu une vie tout à fait extraordinaire. S'il a représenté la France à la Commission des Nations Unies pour le contrôle de l'énergie atomique, il fut aussi l'un des créateurs du CERN, Centre européen pour la recherche nucléaire. Ce livre est un bouquet d'impressions où s'entremêlent la politique, l'évolution de la société et des considérations plus privées. Avec beaucoup d'esprit et de complaisance, François de Rose nous fait revivre les rencontres qui ont ponctué sa vie. C'est ainsi qu'en 1946, il fait la connaissance de Robert Oppenheimer, le scientifique le plus célèbre de cette époque, responsable de la mise au point de l'arme nucléaire, mais également de Henry Kissinger, David Rockefeller, Isidor Isaac Rabi, le général de Gaulle, Albert Einstein. Un parcours très original qui offre un regard éclairé sur le XXe siècle, l'évolution de la recherche scientifique et sur notre époque contemporaine.

Des données textuelles et planimétriques à l’analyse des dynamiques paysagères et foncières. Le cas de Blandy-les-Tours (Seine-et-Marne) du XVIe au XIXe siècle

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Rossi, Albane

2016-01-01

Cette étude doctorale repose, en grande partie, sur la mise en parallèle de données textuelles et planimétriques, modernes et contemporaines, intégrées dans un système d’information géographique. Les documents concernés (un terrier-censier du XVIe siècle, un terrier associé à un plan du XVIIIe siècle, et le cadastre napoléonien de 1845), en inventoriant parcelles et tenanciers/propriétaires, ont en commun de présenter de nombreux renseignements sur la structuration de l’espace rural : la prop...

La représentation cartographique de l'île de la Réunion du XVIIe au XIXe siècle

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Jean-Louis GUÉBOURG

1991-06-01

Full Text Available Du XVIIe au XIXe siècle, la représentation cartographique de l’île de la Réunion a été souvent indigente avant que ne se manifestent, avec retard, les progrès techniques apportés par le calcul précis de la longitude et la triangulation. Deux siècles seront nécessaires pour passer d’une expression cartographique imaginaire puis erronée à une représentation correcte reprise par la cartographie moderne.

Sunlight-induced inactivation of human Wa and porcine OSU rotaviruses in the presence of exogenous photosensitizers

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Romero-Maraccini, Ofelia C.

2013-10-01

Human rotavirus Wa and porcine rotavirus OSU solutions were irradiated with simulated solar UV and visible light in the presence of different photosensitizers dissolved in buffered solutions. For human rotavirus, the exogenous effects were greater than the endogenous effects under irradiation with full spectrum and UVA and visible light at 25 C. For porcine rotavirus, the exogenous effects with UVA and visible light irradiation were only observed at high temperatures, >40 C. The results from dark experiments conducted at different temperatures suggest that porcine rotavirus has higher thermostability than human rotavirus. Concentrations of 3′-MAP excited triplet states of 1.8 fM and above resulted in significant human rotavirus inactivation. The measured excited triplet state concentrations of ≤0.45 fM produced by UVA and visible light irradiation of natural dissolved organic matter solutions were likely not directly responsible for rotavirus inactivation. Instead, the linear correlation for human rotavirus inactivation rate constant (kobs) with the phenol degradation rate constant (kexp) found in both 1 mM NaHCO3 and 1 mM phosphate-buffered solutions suggested that OH radical was a major reactive species for the exogenous inactivation of rotaviruses. Linear correlations between rotavirus kobs and specific UV254 nm absorbance of two river-dissolved organic matter and two effluent organic matter isolates indicated that organic matter aromaticity may help predict formation of radicals responsible for rotavirus inactivation. The results from this study also suggested that the differences in rotavirus strains should be considered when predicting solar inactivation of rotavirus in sunlit surface waters. © 2013 American Chemical Society.

Quand l'indéfini négatif pouvait s'employer au pluriel. Les emplois de « aucun(es » au XIXe siècle

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Denizot Camille

2014-07-01

Full Text Available L’étude porte sur l’existence paradoxale d’indéfinis négatifs au pluriel dans la langue du XIXe siècle. La situation du XIXe siècle atteste en effet d’un état de langue intermédiaire entre deux systèmes stables : celui de l’ancien français où aucun est un indéfini positif qui peut s’employer au singulier comme au pluriel, et celle du français contemporain où aucun est un indéfini négatif qui ne s’emploie plus qu’au singulier, tandis que le sens positif se survit seulement dans la forme de pronom pluriel d’aucuns. Au XIXe siècle, aucun est donc devenu globalement négatif tout en acceptant encore des emplois du pluriel. Si l’explication diachronique motive ce paradoxe, encore faut-il comprendre comment s’interprètent et se justifient ces pluriels pour des indéfinis de sens négatif, dans la synchronie du XIXe siècle. À travers cette étude de cas nous nous interrogeons sur la cohérence synchronique d’un système instable, au croisement de plusieurs évolutions diachroniques. Dans cette optique, nous tentons de comprendre comment se justifie le pluriel des indéfinis négatifs, et comment ces indéfinis pluriels, dont on conçoit mieux la justification a priori pour un sens positif, peuvent développer dans le même état de langue un sens positif et un sens négatif. Nous montrons ainsi que l’emploi du pluriel dans un grammème négatif ne se limite pas au phénomène de l’accord, même s’il tend à s’y cantonner progressivement, et que la coexistence d’un sens négatif et d’un sens positif pour le même grammème n’est pas source d’ambiguïté en synchronie : l’emploi vivant, négatif, vient concurrencer l’emploi positif, résiduel, uniquement dans les contextes à polarité positive et l’interprétation négative y est construite pragmatiquement.

Entre clémence et extrême sévérité. Les juges de la Haute Cour de Namur face aux femmes criminelles dans la seconde moitié du XVIIIe siècle.

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Sarah Auspert

2010-07-01

Full Text Available Au XVIIIe siècle, une nouvelle conception de la femme, développée par les esprits des Lumières, tend à se diffuser dans la société. Au discours religieux qui diabolisait les représentantes du « sexe faible », se substitue progressivement une image plus positive de la femme fondée sur ses fonctions « naturelles » d’épouse et de mère. À travers l’analyse de la répression de la criminalité féminine exercée par la Haute Cour de Namur dans la seconde moitié du XVIIIe siècle, notre mémoire de maîtr...

Les Nobel juifs de chimie le partage du savoir au XX siècle

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Benguigui, Isaac

2010-01-01

L'un des traits marquants et remarquables des Juifs tout au long de leur histoire, plusieurs fois millénaire, a été leur créativité dans tous les domaines, en particulier dans le domaine scientifique. Ils ont participé de façon impressionnante à la remise en cause des valeurs, au démantèlement des dogmes et à l'irruption des forces cachées. On peut d'emblée souligner que la contribution des Juifs à la science a été sans commune mesure avec le pourcentage de la population qu'ils représentent. Cela reste vrai pour la chimie du XXe siècle. A travers la vie et l'oeuvre de 23 prix Nobel de chimie, l'auteur nous livre une histoire passionnante de ces hommes, biens souvent des exilés et d'origine modeste. dont la science fut leur vocation et le partage du savoir leur crédo.

Des femmes dans la cité : les sages-femmes péruviennes du XIXe siècle

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Quiroz-Pérez, Lissell

2014-01-01

L’article s’intéresse à l’intégration dans l’espace public des sages-femmes diplômées péruviennes du XIXe siècle. Cette nouvelle profession naît au lendemain de l’indépendance dans un contexte de lutte contre la dépopulation et de contrôle du corps des femmes, perçues comme futures mères. Alors que les autorités publiques s’en prennent ouvertement aux matrones traditionnelles considérées comme responsables du dépeuplement, l’arrivée d’une sage-femme française, Madame Fessel, permet d’ériger d...

Les emprises militaires dans l’urbanisme grenoblois du XXe siècle : des opportunités foncières au patrimoine paysager

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Philippe Grandvoinnet

2011-06-01

Full Text Available Déclassée en tant que « place forte » en 1925, Grenoble voit son développement urbain conditionné en grande partie par la libération des emprises militaires. Considérées initialement comme de simples réserves foncières, ces structures militaires ont été progressivement investies d’une valeur patrimoniale qui marque fortement certaines opérations d’aménagement urbain et paysager. À travers l’exemple grenoblois, nous évaluerons l’impact des aménagements militaires du XVIIe au XIXe siècle sur l’urbanisme du XXe siècle et dresserons une cartographie urbaine de ce patrimoine militaire en constitution.Grenoble ceased to be qualified as 'place forte' [fortified town] in 1925, and the town's subsequent urban development was largely conditioned by the availability of former military properties. Considered at first as simple real estate opportunities, these military structures were gradually invested with historical and cultural values which feature strongly in certain operations of urban development and landscaping. Starting out from this example at Grenoble, we will try to assess the impact of military installations of the seventeenth to nineteenth centuries on the town-planning of the twentieth century and will map this now recognised heritage in its urban context.

Les salaires des ouvriers du bâtiment à Gérone au XVème siècle

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Victor, Sandrine

1996-06-01

Full Text Available During the XVth century in Girona there was a lot of building offering abundant documentation for a study of the building world. Thanks to the building accounts of the Cathedral and its fortifications, it is possible to study workers'wages and living standards. First of all, a typology of wages needs to be done. Most workers were paid on a daily basis. This kind of salary might vary according to season, activity or professional qualifications. Other workers were on a piece-work basis: for example, traginers, ferrers or argenters. The evolution of wages during the XVth century in Girona follows the general trend observed by J. Hamilton. The wages of best qualified workers remain stable, while those of less qualified vary with a tendency to increase. Then, there is a compression of the salaries. However, this rise is not enough to set off the XVth century's inflation. The living standards of the whole population of building paid workers tend to decrease. Between 1465 and 1490, a master stone cutter loses 42% of his real wage, and a worker 21%. A typical Budget underlines the fact that only a bachelor artisan had a relatively favourable standard of living. In these conditions, the upkeep of a family brought problems.[fr] Les nombreux chantiers qui s'étendent au long du XVème siècle fournissent une documentation abondante sur le monde du bâtiment à Gérone. Grâce aux comptes de la fabrique de la cathédrale et des fortifications, il est possible de dresser une étude sur les salaires et le niveau de vie des principaux métiers de la construction. Il faut d'abord établir une typologie des salaires. La majeure partie des ouvriers est payée à la journée. Cette rémunération peut souffrir de variations selon la saison, l'activité au sein du chantier ou les qualifications professionnelles. Les autres ouvriers touchent un salaire à la tâche ou à la pièce. C'est le cas des traginers, des ferrers ou des argenters. L'évolution des salaires

Les grandes révolutions scientifiques du XXe siècle

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Parrochia, Daniel

1997-01-01

Le siècle qui s'achève aura été marqué par des révolutions scientifiques sans précédent dans la forme comme dans les contenus du savoir. Elles ont retenti sur l'image de la nature comme sur celle de l'homme, brisant les portraits désormais obsolètes qu'en avaient brossés la science et la philosophie classiques. Après Einstein, de Broglie ou Schrödinger, comme après Heisenberg, Dirac ou Feynman, on ne pense plus tout à fait comme avant. Et il en va de même après Poincaré, Hadamard ou Kolmogorov. Trois grandes révolutions physiques seront ici étudiées en détail : la théorie de la relativité (restreinte et générale) ; la mécanique quantique (et ses différentes interprétations) ; la théorie du chaos déterministe (sa préhistoire comme ses applications). Toutes trois contribuent en effet à modifier les réponses que l'on peut apporter aux grandes questions métaphysiques et à esquisser un paysage philosophique nouveau. Dans la tradition de l'épistémologie française, ce livre ent...

The "hour of pink twilight": lesbian poetics and queer encounters on the fin-de-siècle street.

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Flint, Kate

2009-01-01

This essay examines the cultural representation of women's encounters on the fin-de-siècle street and, in particular, the uncertainties that clustered around the possibilities of mutual, or one-sided, same-sex desire accompanying such meetings. It argues, through an examination of lyric poetry, paintings, and short fiction, for the usefulness of twilight--a time of shadowy ambiguity--as a trope to suggest these uncertainities. More than this, it maintains that the lyric and the developing genre of the short story were modes ideally suited to an invocation of the fluid, the uncertain, and the unnamable. This argument is advanced through a close reading of Charlotte Mew's strange short story "Passed," which is read as representative of a transitional moment in lesbian literary history.

L’Université de Perpignan au XVIIIe siècle : palais et temple du savoir à l’âge des Lumières

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Esteban Castañer Muñoz

2012-01-01

Full Text Available L’édifice de l’ancienne Université de Perpignan fut construit en 1759 par l’Ingénieur Lescure. Louis XV, à la demande du gouverneur de Mailly, voulut faire de Perpignan une ville des Lumières. La construction de l’Université avait dans ce contexte une signification particulière. Le bâtisseur s’inspira des modèles architecturaux du palais et du temple suivant les orientations stylistiques de la deuxième moitié du XVIIIe siècle. Avec son amphithéâtre d’anatomie, l’ancienne université de Perpignan est l’un des ensembles universitaires du XVIIIe siècle le plus complet encore existant en France.The former buildings of the University of Perpignan date back to 1759 and were designed by an engineer: Lescure. King Louis XV attending the request of Governor de Mailly wanted to turn Perpignan into a city of the Enlightenment. Considering this circumstance the university buildings themselves had a specific significance. The master-builder was inspired by the style of the palaces and the temples that were built during the second half of the 18th Century. The former University of Perpignan and its anatomy lecture hall constitutes one of the best examples of a well preserved 18th Century French university.

Tangerineira ‘Cleópatra’ submetida a micorrização e a um análogo de brassinosteróide = ‘Cleópatra’ mandarin submitted to mycorrhization and to a brassinosteroid analogue

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Jalille Amim Altoé

2008-01-01

Full Text Available O objetivo deste estudo foi avaliar o efeito de diferentes concentrações de um análogo de brassinosteróide e a inoculação com o fungo micorrízico Ac aulospora scrobiculata (FMA sobre o crescimento e estado nutricional da tangerineira ‘Cleópatra’, da semeadura àrepicagem. O experimento foi realizado em condições de casa de vegetação na Universidade Estadual do Norte Fluminense. Utilizou-se o delineamento experimental em blocos casualizados, em esquema fatorial 5x2 com quatro repetições, sendo cinco concentrações de um análogo de brassinosteróide, Biobras-16 (0,0; 0,1; 0,5; 0,75 e 1,00 mg L-1 e com ou sem inoculação com FMA. A inoculação com o FMA promoveu maior crescimento em altura, número de folhas, diâmetro do caule, área foliar e na massa seca das folhas e do caule. O Biobras-16 promoveu efeito benéfico no diâmetro do caule. Os conteúdos de P, K, Fe e Mnforam mais elevados nas plantas inoculadas. Os resultados mostraram que a associação dos dois fatores estudados modificam o crescimento do porta-enxerto.The objective of this study was to evaluate the effects of different concentrations of a brassinosteroid analogue and inoculation of the vesiculararbuscular mycorrhizal fungi (AMF Acaulospora scrobiculata on the ‘Cleópatra’ mandarin from the sowing until transplant point. The experiment was conducted under greenhouse conditions at Universidade Estadual do Norte Fluminense. The experimental designutilized was a randomized block with a 5x2 factorial scheme with 4 replications, using 5 concentrations of a brassinosteroid analogue, Biobras-16 (0.0; 0.1; 0.5 and 1.00 mg L-1 and with or without AMF inoculation. The AMF inoculation caused increment in height,number of leaves, diameter of the stem, leaf area and dry mass of the leaf and stem. The Biobras-16 promoted an increment of the diameter of the stem. The P, K, Fe and Mn contents were higher in the AMF inoculated plants. Results show that the association

Le luxe publié au dix-huitième siècle : questions de formes

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Audrey Provost

2011-04-01

Full Text Available Parmi la multitude d’ouvrages qui traitent du luxe au xviiie siècle, deux  titres se signalent par une similitude frappante de contenu : Le comte de Valmont de Gérard et Le monarque accompli de Lanjuinais, publiés en 1774. Leur critique du luxe s’appuie en effet sur les mêmes citations, les mêmes morceaux célèbres, les mêmes formules frappantes de Montesquieu, Rousseau ou Helvétius. à se pencher sur les conditions de publication et les profils des deux auteurs, on se rend compte qu’il s’agit pourtant de deux ouvrages se situant aux antipodes l’un de l’autre au sein de l’espace de l’imprimé du xviiie siècle, mais aussi dans l’historiographie, roman apologétique s’inscrivant dans l’orthodoxie d’Ancien Régime pour l’un, « livre philosophique » considéré comme exemplaire d’une critique du luxe subversive pour l’autre. C’est en analysant de plus près les dispositifs d’écriture et l’usage des citations que l’on saisit la production de sens très contrastés à partir d’un matériau similaire.The Publication of Luxury in the Eighteenth Century: a Question of FormAmong the many eighteenth-century works on luxury, two stand out for their striking resemblances: Le comte de Valmont by Gérard and Le monarque accompli by Lanjuinais, both published in 1774. Both criticize luxury by referring to the same quotations, the same famous passages, the same salient sentences by Montesquieu, Rousseau or Helvétius. Nevertheless, when one examines these writers’ publishing conditions and authorial figures, one is forced to acknowledge that these books are completely different and belong to distinct print cultures and historiographic traditions: one is an epistolary novel typical of the Old Regime’s orthodoxy; the other is a “philosophical book” that exemplifies more subversive critiques of luxury. A detailed analysis of their writing styles and of their use of quotations reveals how very

Analyse géopolitique et diplomatie au XVIe siècle. La qualification de l’ennemi dans les relazioni des ambassadeurs vénitiens

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Romain Descendre

2007-02-01

Full Text Available Cet article examine la textualité des relations des ambassadeurs vénitiens du xvie siècle. S’attachant en particulier à la partie finale des relazioni, traditionnellement consacrée aux amitiés et inimitiés princières, l’analyse rend visible la façon dont ces discours constituent l’une des premières matrices de la pensée des relations internationales à l’époque moderne.

Normes religieuses et identité civique dans les cités de Grèce égéenne (IIe siècle av. J.-C.-IIIe siècle ap. J.-C.

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Yves Lafond

2010-04-01

Full Text Available Un règlement athénien, daté du IIe siècle de notre ère, nous plonge dans une séance de l’assemblée des Iobacches convoquée pour ratifier les statuts (δόγματα présentés à l’occasion d’un renouvellement du prêtre et du vice-prêtre de l’association. La lecture des statuts soulève les acclamations : « Observons-les (ces statuts pour toujours », τούτοις ἀεὶ χρώμεθα,« Restitue les statuts », ἀνάκτησαι τ’ ὰ δόγματα, « Qu’on mette les statuts sur une stèle », ἐν στήλῃ τὰ δόγματα. Il est alors procé...

Archives d’architectes et églises du XXe siècle

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Simon Texier

2012-05-01

Full Text Available Depuis une vingtaine d’années, les archives d’architecture du XXe siècle, conservées au sein de la Cité de l’architecture et du patrimoine, ont été le support d’une considérable avancée de la recherche. L’architecture religieuse en a elle aussi bénéficié ; elle n’en souffre pas moins toujours d’un certain retard, et ce malgré l’extrême richesse des fonds d’architectes ou d’entrepreneurs. L’importance des études préparatoires et des projets non réalisés ou le développement massif de la construction d’édifices religieux après 1945 comptent parmi les axes des recherches possibles.Over the past twenty years, the 20th-century architectural archives held today at the Cité de l’Architecture et du Patrimoine have underpinned considerable progress in research in the history of architecture. Religious architecture has also benefited from this progress, although, despite the considerable interest of the archives of certain architects or building firms, studies in this particular field are still lacking,. Amongst the new research directions that can be suggested today, this article draws attention to two fields: the study of preliminary projects and of projects that, in the end, were not carried out, and the massive development of new religious building after 1945.

Pierre Swiggers, Les Conceptions linguistiques des Encyclopédistes, Etude sur Ia constitution d'une théorie de Ia grammaire au siècle des Lumières, Sammlung Groos 21, Julius Groos Verlag-Heidelberg- Leuven University Press, Heidelberg 1984, 165 pp.

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Pavao Tekavčić

1986-12-01

Full Text Available Le petit livre dont nous présentons ici lecompte rendu est I'oeuvre du jeune savant Pierre Swiggers, chercheur qualifié au Fonds national beige de la recherche scientifique, linguiste et philologue qui nous a donné dejà une serie d'études, sur le siècle des Lumières (L'Encyclopédie et la linguistique au XVI/le siècle, «Linguisti­ cae Investigationes» 311979; La grammaire dans /'Encyclopédie: Etat actuel des étu­ des, «Beiträge zur romanischen Philologie» 20/1981; La théorie syntaxique dans  /'Encyclopédie, «Lingua e stile» 18/1983 etc., sur l'historiographie linguistique (tout récemment: L'article en français: l'histoire d'un problème grammatical, «Re­ vue de Linguistique Romane» 49/1985, sur la linguistique du XVIIe et du XVIIIe siècle en général, etc. L'Auteur est done bien un spécialiste qualifié pour offrir au public linguistique une synthèse de ses recherches sur les théories grammaticales dans l'Encyclopédie.

À propos du lexique juridique en ancien français avant le 13e siècle : la Règle de saint Benoît et le Perceval de Chrétien de Troyes

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Schauwecker Yela

2012-07-01

Full Text Available La plus ancienne traduction de la {em Règle} de saint Benoît en franc{c}ais, rédigée en dialecte picard-wallon, date de la première moitié ou du milieu du {sc xii}$^{m e}$~siècle. On veut montrer que son auteur, pour qui le changement de langue, n'est pas le premier objectif s'efforce de transférer le texte de son milieu originel de l'Antiquité tardive dans le monde chevaleresque-féodal du {sc xii}$^{m e}$~siècle. Même sans nécessité apparente, quand il a eu à sa disposition l'équivalent du mot employé dans la {em Regula}, il substitue aux mots latins des termes juridiques et féodaux franc{c}ais. par Son texte, en tant que document de droit pour les moines, devient ainsi une source de vocabulaire juridique franc{c}ais avant le {sc xiii}$^{m e}$~siècle, c'est-à-dire dans un temps où les documents juridiques en langue vulgaire sont extrêmement rares. Cela est dû au fait que la justice, dans le Nord, fondée sur des coutumes, utilisait la langue vernaculaire à l'oral. La terminologie juridique franc{c}aise est bien enracinée dans la langue courante de l'époque~: leur insertion dans les Lais et les Chansons de geste en fait preuve. Mais cette terminologie est souvent méconnue par la lexicographie traditionnelle de l'ancien franc{c}ais, en raison des contextes littéraires et figurés. par

Sylvie CHAPERON, La médecine du sexe et les femmes. Anthologie des perversions féminines au XIXe siècle

OpenAIRE

Edelman, Nicole

2009-01-01

L’ouvrage présente une anthologie de quarante huit cas de perversions féminines publiés par vingt-quatre médecins différents du xixe siècle, précédés d’une introduction de vingt pages et se concluant par une bibliographie de trois pages. Les cas sont classés selon les termes de l’époque dans l’ordre suivant : onanisme (12 cas), nymphomanie (13), érotomanie (5), anaphrodisme, frigidité et impuissance (1), bestialité, zoophilie (2), nécrophilie (1), exhibitionnisme (1), saphisme, tribadisme et ...

Les communautés savantes européennes à la fin du siècle des Lumières

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René Sigrist

2013-08-01

Full Text Available Le présent article traite de la localisation des savants européens à la fin du XVIIIe siècle. Une première méthode consiste à cartographier la «République des sciences» à partir de la Liste des astronomes connus actuellement vivants établie par Jean III Bernoulli entre 1776 et 1779. Une seconde méthode localise les membres et correspondants des six principales académies scientifiques de l'époque, soit celles de Paris, Londres, Berlin, St-Pétersbourg, Stockholm et Bologne. Dans le cas particulier de la France, la recherche met en évidence l'articulation spatiale entre la communauté académique de la capitale, les villes de province et les centres étrangers.

Le travesti dans le théâtre du xixe siècle : une distribution à contre-genre ?

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Khoury, Camille

2018-01-01

Quelques-unes des actrices les plus célèbres du xixe siècle ont laissé à la postérité le souvenir de leurs rôles travestis. C’est notamment le cas de Virginie Déjazet – au point que le déjazet est rapidement devenu synonyme de rôle travesti – ou encore de Sarah Bernhardt. Le travesti est alors un spectacle commun sur les scènes académiques françaises – tandis que certains rôles sont écrits pour être joués en travesti, de grandes actrices s’emparent de rôles masculins pour confronter leur géni...

Crescimento e composição mineral do porta-enxerto tangerineira cleópatra cultivado em substrato acrescido de polímero hidrorretentor Growth and mineral composition of the cleópatra mandarin rootstock growing on substratum added with hidroretentive polymers

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Marcelo Vichiato

2004-08-01

Full Text Available Os efeitos de polímero hidrorretentor acrescido ao substrato foi avaliado na fase inicial de produção do porta-enxerto tangerineira 'Cleópatra' cultivado em tubetes plásticos com substrato comercial à base de casca de Pinus compostada e parcialmente fertilizado. Foi utilizado o delineamento experimental de blocos casualizados com três repetições, sendo os tratamentos seis doses do hidrorretentor (0, 4, 8, 12, 16 e 32 mg.dm-3 incorporado ao substrato, com 60 plantas úteis por parcela. Avaliaram-se o Índice de Velocidade de Emergência (IVE, altura de planta, peso da matéria seca total e seus teores de N, P, K, Ca, Mg, S, B, Cu, Mn, Zn e Fe, e valores de pH do substrato ao final do período experimental. A incorporação do hidrorretentor ao substrato de cultivo promoveu elevação nos valores do pH do substrato, decréscimos no IVE, no crescimento e no peso da matéria seca total, não havendo alteração expressiva no estado nutricional dos porta-enxertos aos 150 dias pós-semeadura.The effects of hidroretentive polymers added to the substratum was evaluated in the initial phase of production of 'Cleópatra' mandarin rootstock. They were cultivated in container seedlings with commercial pine bark substratum composted and partially fertilized. The randomized blocks experimental design was used with three replications, being the treatments six doses of the hydroretentive polymer (0, 4, 8, 12, 16 and 32 mg.dm-3 incorporated to the substratum. The Index of Emergency Speed (IVE, plant height, weight of the matter total drought and their tenors of N, P, K, Ca, Mg, S, B, Cu, Mn, Zn and Fe, and values of pH substratum were evaluated. The use of incorporated hydroretentive polymer to the cultivation substratum increased the values of pH of the substratum, decreases in IVE, the growth and the weight of the total dry matter, not having expressive alteration in the nutritional state of the rootstocks.

La bande dessinée en Belgique francophone au XIXe siècle

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Frédéric Paques

2012-02-01

Full Text Available La Belgique a une grande tradition de production de bandes dessinées et reconnaît le neuvième art comme l’un des fleurons de sa culture nationale. Pourtant, la plupart des livres traitant d’histoire de la bande dessinée dans ce pays ignorent totalement l’époque pré-hergéenne. Et pour cause, la production de bande dessinée en Belgique est à la fois relativement peu nombreuse et, pour une bonne part, tributaire de l’influence étrangère. De plus, les bandes dessinées présentant du texte sous l’image ont longtemps été complètement ignorées par les historiens du sujet. Cet article se propose de rechercher les diverses apparitions de séquences d’images au XIXe siècle et de les contextualiser. Nombre des exemples que nous avons trouvés constituent des expériences sans lendemain, produites dans des contextes différents de celui qui donnera naissance à la bande dessinée belge de l’âge d’or : trouver une filiation directe n’était pas notre but premier. Pourtant, du Déluge à Bruxelles créé en 1843 par Richard de Querelles aux images populaires du Liégeois Georges Ista, juste avant la première guerre mondiale, la bande dessinée belge au XIXe siècle se révèle au final d’une richesse et d’un intérêt insoupçonnés jusqu’ici.Belgium has a great tradition of production of comic strips and recognizes the 9th art as one of the jewels of its national culture. Nevertheless, most of the books dealing with history of the comic strip in this country ignore totally the time before Hergé. For a good reasons : the production of comic strip in Belgium is relatively rare and, largely, dependent on the foreign influence. Furthermore, comic strips presenting text under the image were completely ignored for a long time by the historians of the subject. What we suggested making in our work, is looking for the diverse appearances of sequences of images through time and contextualise them. Number of the examples

Smart campus transit laboratory for research and education.

Science.gov (United States)

2011-12-31

A joint effort by the Ohio State University (OSU) Transportation and Parking Services, OSU College of Engineering, OSU Department of Civil and Environmental Engineering and Geodetic Science, and Clever Devices has recently succeeded in equipping the ...

La chimie du XVIIe siècle : une question de principes

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Rémi Franckowiak

2008-04-01

Full Text Available Le tournant du XVIIe au XVIIIe siècle est une période décisive pour l’histoire de la chimie qui passe de la reconnaissance institutionnelle à la contestation de son fondement théorique, pour apparaître au final comme la seule partie de la Physique à pouvoir prétendre atteindre la « vérité certaine ». Ce qui se joue alors n’est rien de moins que la redéfinition de ses principes, à savoir son socle de vérités sur lequel s’appuie la science chimique. Cette période est en fait la dernière étape de l’évolution du rapport entre les deux dimensions – théorique et pratique – dans lesquelles se déploie la chimie, qui a vu, par le développement de l’usage des principes dits seconds, l’ensemble des principes chimiques entrainé vers un réalisme empirique, ayant pour effet d’ôter de la chimie toute cohérence théorique. Aussi l’apparition du mécanisme – pas plus celui de Boyle – n’est-il en réalité responsable du bouleversement que connaît la chimie ; elle n’est pas davantage responsable de sa régénération au tout début du XVIIIe siècle. La conscience de la faiblesse théorique de la chimie va devenir pour elle promesse de vigueur théorique sur la base de ce qui représente sa force : l’expérience. À la suite de la perte de ce qui fut certitude, le chimiste devient un être à ré-instruire. Un chimiste tel que Samuel Cottereau Du Clos illustre parfaitement le passage d’une science chimique comme connaissance des principes à une chimie comme science cette fois du vraisemblable.The last decades of 17th century represent a decisive period for the history of Chemistry which switched from institutional recognition to dispute of its theoretical basis, to seem finally, during the very first years of the next century, the only part of Physics being able to claim reaching the “unquestionable truth”. What did happen then is nothing less than the redefinition of principles of Chemistry

La grange seigneuriale de « l’hébergement » de Flux à Lailly-en-Val (Loiret au XIVe siècle

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Daniel Bontemps

2012-04-01

Full Text Available La grange seigneuriale de Flux à Lailly-en-Val (Loiret est construite sur le lit majeur de la Loire en zone primitivement inondable. Transformée par les siècles, elle n’en conserve pas moins son pourtour d’origine et une charpente à fermes et pannes sur poteaux dont les bois ont été coupés vers 1320 (dendrochronologie. Grâce à des aveux du XIVe siècle, postérieurs d’un tiers de siècle à sa construction, on constate qu’elle occupait une situation à part dans « l’hébergement » de Flux. Son implantation près de Beaugency permettait de transporter la part des récoltes qui y étaient entreposées en peu de temps pour y être vendue.The seigniorial barn of Flux at Lailly-en-Val (Loiret was built on the main bed of the river Loire which, at the time, was liable to inundation. The building has been modified over the centuries but nonetheless conserves its original footprint and its original wooden trusses and purlins. These are supported by posts the timber of which, according to dendrochronological analysis, was cut in about 1320. In archival consents dating from the 14th century, a third of a century after the construction, it is possible to see how the barn occupied a peripheral situation in the ‘hébergement’, the lodging of Flux. Its location near Beaugency allowed for parts of the harvest to be rapidly stored in the barn prior to sale.

A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro.

Science.gov (United States)

Weng, Jing-Ru; Bai, Li-Yuan; Omar, Hany A; Sargeant, Aaron M; Yeh, Ching-Tung; Chen, Yuan-Yin; Tsai, Ming-Hsui; Chiu, Chang-Fang

2010-10-01

Indole-3-carbinol (I3C), a naturally occurring phytochemical found in cruciferous vegetables, has received much attention due to its translational potential in cancer prevention and therapy. In this study, we investigated the antitumor effects of OSU-A9, a structurally optimized I3C derivative, in a panel of oral squamous cell carcinoma cell lines, SCC4, SCC15, and SCC2095. The antiproliferative effect of OSU-A9 was approximately two-orders-of-magnitude higher than that of I3C. Importantly, normal human oral keratinocytes were less sensitive to OSU-A9 than oral cancer cells. This antiproliferative effect of OSU-A9 was attributable to the induction of mitochondrial-dependent apoptosis as evidenced by sub-G1 accumulation of cells, poly ADP-ribose polymerase cleavage, and cytochrome c release from the mitochondria. OSU-A9 down regulates Akt and NF-κB signaling pathways, leading to changes in many downstream effectors involved in regulating cell cycle and apoptosis. Moreover, the observed down regulation of IKKα and IKKβ expression by OSU-A9 is not reported for I3C. OSU-A9 also induces both the production of reactive oxygen species and the endoplasmic reticulum stress. Taken together, these results suggest the translational value of OSU-A9 in oral squamous cell cancer therapy in the future. Copyright © 2010 Elsevier Ltd. All rights reserved.

Les voies de l’américanisation: espace américain et écriture de l’histoire au XVIe siècle

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Serge Gruzinski

2012-01-01

Full Text Available Si depuis la Renaissance l’écriture de l’histoire s’est développée sous diverses modalités dans la chrétienté latine, elle s’est métamorphosée en s’installant sur le sol américain. Alors que la discipline européenne est censée adopter ses contours « modernes » dans l’Italie du XVe siècle avec Leonardo Bruni et Flavio Biondo et qu’elle acquiert sa vitesse de croisière dans la première moitié du siècle suivant dans le sillage des Machiavel et des Guichardin, l’histoire que l’on écrit sur le sol américain, depuis le Nouveau Monde, prend une autre tournure: elle s’américanise. Cette nouvelle orientation se révèle indissociable de l’espace maritime et intercontinental dans lequel elle se déploie. Et ce n’est pas qu’une question d’échelle ou de vastitude.A partir de la época del Renacimiento, la escritura de la historia se desarrolló según varias modalidades en la cristiandad latina, sin embargo hablaremos de metamorfosis tratándose de la historia que se redactó en el suelo americano. Se suele afirmar que la disciplina en Europa adopta su forma moderna en la Italia del siglo XV con Leonardo Bruni y Flavio Biondo y adquiere su madurez en la primera mitad del siglo XVI con Maquiavelo y Guicciardini ; en cambio la historia que se escribe desde el Nuevo Mundo cobra otro cariz : se americaniza. Esta nueva orientación resulta indisociable del espacio marítimo e intercontinental en el que se formula. Y no solo es un asunto de escala ni de amplitud espacial.

Du bon maniement de l’argent du roi en Espagne au XVIIIe siècle. Les enseignements d’un procès pour fraude

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Anne Dubet

2010-07-01

Full Text Available Pour nombre d’historiens – dont je fais partie – les réformes financières entreprises par les premiers Bourbons d’Espagne au XVIIIe siècle n’affectent pas tant l’organisation fiscale de leurs territoires que leur administration. Avant que de modifier la répartition sociale des contributions, il s’agit de rendre au roi et à ses ministres de confiance la décision en matière de dépenses et de s’assurer de son exécution. Ce projet de contrôle accru du roi sur ses propres deniers se traduit certes...

Remarques sur certains archaïsmes iconographiques dans les peintures murales byzantinisantes de la Pologne au XVe siècle

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Semoglou Athanassios

2008-01-01

Full Text Available (francuski L'étude des certains rarissimes archaïsmes iconographiques dans les peintures murales de style byzantin en Pologne de l'époque du roi Ladislas Jagiello (fin du XIVe - début du XVe siècle a révélé la pénétration d'une tradition riche et originale qui remonte au milieu syro-palestinien des premiers siècles du christianisme. Ce langage pictural conservateur traduit le phénomène du retour à des formules archaïques et s'inscrit dans l'effort, de la part du roi, d'harmoniser les tensions politiques et religieuses des deux communautés du pays (orthodoxe et catholique, grandi après l'union du grand Duché de Lituanie au royaume de Pologne en 1386. .

Mission locale, vision globale : utopie et vie sociale dans les missions jésuites en Amazonie au XVIIe siècle

OpenAIRE

Guzmán, Décio de Alencar

2015-01-01

Penser les missions jésuites au XVIIe siècle, c’est penser le monde des prophéties du « Cinquième Empire » d’Antônio Vieira. Cela signifie aussi penser l’expérience missionnaire vécue par cet « homme-monde ». En tant que tel, Vieira projeta vers l’avenir des réalités politiques entièrement neuves imaginées par lui et qui n’avaient jamais existé avant. En arrivant au Maragnon, en 1653, Antônio Vieira, supérieur de la Mission des pères de la Compagnie de Jésus, commença son expérience avec l’es...

La réaction des pays d'Islam face aux Croisades et aux États latins, fin du XIe - milieu du XIIIe siècle

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Van Renterghem , Vanessa

2000-01-01

Cet article, rédigé à l'occasion de la question d'agrégation d'histoire portant sur " Les relations entre les pays d'Islam et le monde latin du milieu du Xe au milieu du XIIIe siècle " (2000-2002), examine différents aspects des relations entre Croisés et musulmans, vues des pays d'Islam. Il s'intéresse tout d'abord à l'évolution de l'image des Croisés dans les sources arabes de l'époque ainsi qu'au sort des musulmans sous domination franque. Il retrace ensuite les différentes étapes de la ré...

La décadence à la fin du XIXe siècle espagnol: une esthétique de la provocation

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Xavier Escudero

2012-03-01

In what way(s do these concepts both make use of and take part in an aesthetic of transgression, or a provocative pose? What does Spanish decadentism really mean, and what are its expressions? In order to answer these questions, we shall first look at the concept of decadentism as applied to the sociocultural phenomenon of Spanish literary bohemianism, which gathers writers and artists defined by constant failure, loose morals and the "cursed" poses they adopt. Then we shall highlight the literary expressions of decadence through the writings of Manuel Machado, Rubén Darío and Ramón María del Valle-Inclán, three prominent authors of the fin-de-siècle letters. Finally we shall take a closer look at the decadent motifs of marginality and lust in the little-known field of modernist bohemian poetry.

La bouche au XVIIe siècle

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Bruno Faux

2009-12-01

Full Text Available « Qu’y a-t-il outre l’intelligence de plus prodigieux que la bouche de l’homme ? » (G. P. Harsdörffer. Parce que la bouche est non seulement le siège de l’oralité, mais aussi celui du goût, ainsi qu’un lieu d’expression des affects, elle s’illustre dans la littérature allemande du XVIIe siècle comme un topos dense, capable de générer diverses sortes de récits, autour duquel s’articule un vaste réseau de sens. Voie de passage entre le dedans et le dehors du corps, elle est l’organe frontière proprement dit. D’un point de vue physiologique et rhétorique, elle représente un espace stratégique : la frontière anatomique qu’est la bouche, qui est aussi une frontière symbolique, devient dans l’œuvre de Georg Philipp Harsdörffer ou de Friedrich von Logau le théâtre de conflits éthiques, de la dialectique de l’être et du paraître, de la sincérité et de la fausseté. Une problématique anthropologique fondamentale de la première modernité se reflète dans la métaphore de la frontière, du seuil, du passage, et trouve son expression dans l’opulence des images de la bouche présentes dans la littérature de cette époque. C’est précisément dans la langue poétique, dans la vive picturalité du langage, que les auteurs de l’âge baroque parviennent à établir une forme de savoir qui leur est propre.„Was ist nechst dem Verstand / wunderreicher als der Mund deß Menschen?“ (G. P. Harsdörffer. In der deutschen Literatur des 17. Jahrhunderts ist der Mund ein dichter und vieldeutiger Topos, der sich durch ein starkes Potential an Handlung auszeichnet. Er dient nicht nur dem Reden und Schmecken, sondern auch dem Ausdruck der Gefühle. Als Übergang zwischen Innen und Außen ist er das eigentliche Organ der Grenze. In physiologischer wie rhetorischer Hinsicht wird er damit zu einem strategischen Raum. Bei Georg Philipp Harsdörffer oder Friedrich von Logau wird diese anatomische und zugleich

La couleur des palais royaux espagnols du xvie au xviiie siècle The colour of Spanish royal palaces from the sixteenth to eighteenth centuries

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Juan Hernández Ferrero

2008-05-01

Full Text Available En Espagne, l’architecture des châteaux royaux, monochrome, n’accorde aucune véritable importance esthétique à la couleur. Ainsi, le monastère de l’Escurial, également palais royal, utilise le gris (teinte quelque peu modifiée de nos jours comme élément conférant une uniformité architecturale. Mais, au cours du xviie siècle, les façades du nouveau palais du Buen Retiro reçoivent une coloration discrète qui vise à les mettre en valeur. La couleur intègre alors le vocabulaire des architectes pour finalement s’affirmer dans l’usage au xviiie siècle, comme nous le verrons avec les palais royaux de Madrid, du Pardo, de Riofrío et de La Granja de San Ildefonso. Ainsi se trouve contredite la théorie initiale d’absence de couleur dans les résidences royales d’Espagne. Cette évolution est le fruit de l’influence européenne sur l’art espagnol.In Spain, the monochromatic architecture of royal chateaux placed no real aesthetic importance on colour. The El Escurial monastery, also a royal palace, used the colour grey (a tone somewhat modified today to provide an architectural uniformity. But during the seventeenth century the facades of the new Buen Retiro palace were given a discreet colouring that aimed to enhance them. Colour began to be used by architects, and widely so in the eighteenth century, as we will see with the royal palaces of Madrid, El Pardo, Riofrío and La Granja de San Ildefonso – contradicting the initial theory that colour was absent from the royal residences of Spain. This development was a result of the European influence on Spanish art.

Un représentant d'États européens dans l'arriète-pays ottoman. Le cas de Sponty à Serrès (fin XVIIIe-début XIXe siècle

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Georges Koutzakiotis

2009-01-01

Full Text Available La domination des commerçants chrétiens orthodoxes, dans l'arrière-pays balkanique de l'Empire ottoman, et celle des Européens, dans les Échelles du Levant, pendant le XVIIIe siècle, sont aujourd'hui bien connues. Cependant, les Européens essayèrent, déjà depuis le même siècle, d'étendre leur rayon d'action à l'intérieur de l'Empire, en établissant des sujets non-ottomans comme agents commerciaux et consulaires et en écartant ainsi les intermédiaires autochtones. Un de ces premiers essais, plus exactement de la part de l'Autriche et de la France, eut lieu à Serrès, centre économique important des Balkans grâce au commerce du coton. Michel Sponty, protégé (beratlı de la France d'origine vénitienne, fut le seul de ces agents commerciaux et consulaires qui réussit finalement à s'enraciner dans la société de Serrès, en renonçant pourtant à son identité franco-levantine et en adoptant celle des commerçants dominants, c'est-à-dire l'identité du chrétien orthodoxe.

Madame de Genlis dans la littérature Russe du XIXe Siècle : Pouchkine, Léon Tolstoï et autres

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Alla Polosina

2013-09-01

Full Text Available Dans cet article nous examinons la réception dе Madame de Genlis chez plusieurs auteurs russes du XIXe siècle. Pouchkine la nomma « écrivailleuse sans talent », malgré le fait que ses Mémoires suscitaient son grand intérêt. Léon Tolstoï utilisa le nom de Madame de Genlis dans Guerre et Paix pour mettre en relief le caractère de ses protagonistes : Koutouzov et Vé-ra Rostova. Leskov écrivit un petit chef-d'oeuvre, L’Esprit de Madame de Genlis, sur sa déifica-tion dans la haute société. La réception de Madame de Genlis en Russie paraît étroitement liée au statut aristocratique de son oeuvre, qui servit ainsi de modèle culturel aux élites fran-cophiles russes.

Tensions, Réformes et Recherche du consensus: Vatican II dans l’itinéraire de l’Église catholique au XXe siècle - DOI: 10.5752/P.2175-5841.2011v9n24p963

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Gilles Routhier

2012-02-01

Full Text Available Tensions, Réformes et Recherche du consensus: Vatican II dans l’itinéraire de l’Église catholique au XXe siècle(Tensions, reforms and consensus : Vatican II in the itinerary of the Catholic Church in the twentieth centuryRésumé Contrairement à ce que l’on affirme parfois, les tensions que l’on retrouve dans l’Église catholique au moment de la réception du concile ne sont pas nées avec le concile, mais s’enracinent au cours du siècle qui précéda Vatican II. Elles portent principalement sur le rapport de l’Église catholique au monde moderne. À Vatican II, si les Pères conciliaires ont été d’accord pour généraliser et accélérer l’effort de mise à jour de l’Église entamée depuis quelques décennies, quelques-uns ont refusé le discernement opéré par l’Église catholique sur l’enseignement des papes, depuis Pie IX, sur le rapport de l’Église avec le monde moderne. Les évêques appartenant à la majorité ont estimé qu’il fallait re-recevoir ces enseignements portés dans des circonstances historiques différentes, et les apprécier à la lumière des situations nouvelles dans lesquelles évoluait désormais l’Église catholique. L’opposition actuelle au concile refuse ce discernement et voudrait, par-delà le concile, revenir aux positions tenues au XIXe siècle. Mots-clés: Vatican II; L’Église Catholique. XXe siècle. Tensions. Réformes. Consensus Abstract To the contrary of what is commonly said, the tensions in the Catholic Church at the time of reception of the Council did not originate within the council, but are rooted in the course of the century prior to Vatican II. These tensions relate mainly to the relationship of the Catholic Church with the modern world. If the Fathers of the Second Vatican agreed to upgrade the Church, after a few decades some priests refused to follow the teachings of the Popes about the relationship of the Church with the modern world. Most bishops

Via Lyon: Parcours de romans et mutations éditoriales au XVIe siècle. Partie II. La circulation des textes entre Lyon et Paris

Directory of Open Access Journals (Sweden)

Gaëlle Burg

2015-07-01

Full Text Available La première partie du dossier Via Lyon (Carte Romanze 2/2 [2014] analysait le rôle de carrefour économique et culturel de la ville de Lyon dans la constitution d’une identité éditoriale des romans publiés en France au XVIe siècle. L’étude de ces «parcours de romans» conduit à replacer, en cette seconde partie du dossier, la notion d’«étape lyonnaise» dans la dynamique qui anime les deux principaux centres d’imprimerie français de la Renaissance. L’étude des pérégrinations éditoriales, de Paris à Lyon et de Lyon à Paris, de Lancelot du Lac (G. Burg, de Valentin et Orson (M. Colombo Timelli et de Méliadus chevalier de la Croix (A. Réach-Ngô met ainsi au jour les diverses formes de circulation, d’adaptation et de réappropriation que les ateliers parisiens et lyonnais confèrent aux œuvres romanesques qui passent sous leurs presses tout au long du siècle. The first part of the file Via Lyon (Carte Romanze 2/2 [2014] analyzed the role of economic and cultural crossroad of Lyon city in the constitution of an editorial identity of novels published in France in the sixteenth century. The study of these «novels’ route» leads to situate the concept of «Lyon step» in the dynamics which animates the two major French printing centers of the Renaissance. The editorial peregrinations, from Paris to Lyon and from Lyon to Paris, of three french novels, Lancelot du Lac (G. Burg, Valentin and Orson (M. Colombo Timelli and Méliadus chevalier de la Croix (A. Réach-Ngô, shows the various forms of circulation, adaptation and reappropriation that various Parisian and Lyon workshops give to novels they print throughout the century. 

Le bestiaire au dix-neuvième siècle. Animalité, pauvreté et criminalité dans Les mystères de Paris

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Nigel Lezama

2015-12-01

Full Text Available Cet article présente le contexte épistémologique de la question animale au dix-neuvième siècle et interroge la façon dont le feuilleton d’Eugène Sue, Les Mystères de Paris, déploie la figure animale dans la mise en scène des marginaux. Bien qu’une telle peinture risque de nuire à l’animal par le biais d’un positivisme qui le réifie, le feuilleton trouve un moyen d’énoncer un nouvel argument contre la souffrance animale tout en soulignant la nécessité de réfléchir aux grands problèmes sociaux et à leur résolution par le biais du traitement des animaux.

Commis, artisans, ouvriers. Les métamorphoses du salariat dans l’Égypte du XIXe siècle

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Pascale Ghazaleh

2012-01-01

Full Text Available Cet article se propose d’analyser l’évolution du travail salarié en Égypte pendant la première moitié du XIXe siècle à la lumière des modifications apportées au système des charges vénales, qui permet aux sujets du sultan d’accéder au statut de ses serviteurs en achetant le droit de toucher une rémunération. Les réformes juridiques, militaires, économiques et administratives qu’institue Muhammad ‘Alî (r. 1805-1848 en Égypte vont ériger les instances de l’État naissant en source de rémunération et point de référence primaire des détenteurs de charges. Pendant la période 1840-1860, les recrutements de fonctionnaires et de travailleurs connaîtront un repli ; et, lorsque la question du travail salarié est abordée à part entière dans le discours public des années 1880, c’est sous son versant politique, comme métaphore de la tutelle coloniale.

Approches des productions de terres cuites architecturales icaunaises, du Moyen Âge à la Révolution industrielle (Ve-XIXe siècle. Diagnostic documentaire et instruments de travail

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Sylvain Aumard

2003-11-01

Full Text Available Origine de la rechercheLes terres cuites architecturales (tuiles, briques, carreaux… sont souvent délaissées par les archéologues qui - faute d’études de référence - conservent peu ou pas ce matériau ou se contentent de garder les exemples les plus remarquables. Il s’agit pourtant d’un matériel archéologique qui possède aussi sa propre histoire, ses propres évolutions et spécificités. Produit en grand nombre à partir du XIIe siècle, il se distingue de la céramique de table par une évolution ...

Le verre à vitre et l’archéologie de la fin de l’Antiquité au XIIe siècle. Premières approches et perspectives

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Christian Sapin

2007-08-01

Full Text Available Le vitrail a longtemps été considéré comme représentatif du plein Moyen Âge (XIe-XIIe siècle au plus tôt. Si quelques textes historiques impliquaient l’existence de vitrail à l’époque mérovingienne, la rareté des verres plats archéologiques, datés, ne permettait pas d’écrire avec précision une histoire du vitrail.Cette histoire est depuis quelques années revisitée par les sources archéologiques, aussi ténues puissent-elles paraître. La révolution la plus importante est, dans les années 1960,...

À « l’ombre du Père » ? L’autorité maternelle dans la première moitié du XVIIIe siècle

OpenAIRE

DOYON, Julie

2007-01-01

Du renforcement de la « monarchie paternelle » à l’existence d’un « empire des mères », la confrontation des sources du droit civil et des archives criminelles du Châtelet, au premier XVIIIe siècle, donne une vision complexe des rapports noués entre l’expérience de la maternité et l’exercice de l’autorité. Statutairement, les mères légitimes sont associées, sur un mode mineur ou de plein droit dans le cas du veuvage et de l’institution tutélaire, à l’exercice de l’autorité paternelle. Mais en...

CLAVATA3-like genes are differentially expressed in grape vine (Vitis vinifera) tissues.

Science.gov (United States)

Tominaga-Wada, Rumi; Nukumizu, Yuka; Wada, Takuji; Sawa, Shinichiro; Tetsumura, Takuya

2013-10-15

The CLAVATA3 (CLV3)/endosperm surrounding region [(ESR) CLE] peptides function as intercellular signaling molecules that regulate various physiological and developmental processes in diverse plant species. We identified five CLV3-like genes from grape vine (Vitis vinifera var. Pinot Noir): VvCLE 6, VvCLE 25-1, VvCLE 25-2, VvCLE 43 and VvCLE TDIF. These CLV3-like genes encode short proteins containing 43-128 amino acids. Except VvCLE TDIF, grape vine CLV3-like proteins possess a consensus amino acid sequence known as the CLE domain. Phylogenic analysis suggests that the VvCLE 6, VvCLE25-1, VvCLE25-2 and VvCLE43 genes have evolved from a single common ancestor to the Arabidopsis CLV3 gene. Expression analyses showed that the five grape CLV3-like genes are expressed in leaves, stems, roots and axillary buds with significant differences in their levels of expression. For example, while all of them were strongly expressed in axillary buds, VvCLE6 and VvCLE43 expression prevailed in roots, and VvCLE25-1, VvCLE25-2 and VvCLE TDIF expression in stems. The differential expression of the five grape CLV3-like peptides suggests that they play different roles in different organs and developmental stages. Copyright © 2013 Elsevier GmbH. All rights reserved.

La science comme pratique d’intégration dans la société des princes. Les Grimaldi de Monaco et la curiosité savante (xviie–xviiie siècle)

OpenAIRE

Thomas Fouilleron

2011-01-01

Jusque-là seigneur de Monaco, Honoré II (1597-1662) prend, en 1612, le titre de prince. En 1641, il se place sous la protection du roi de France qui confirme, par le traité de Péronne, sa souveraineté. Parallèlement à son effort d’affirmation politique, il s’attache à intégrer la société européenne des princes en adoptant les pratiques culturelles de la distinction monarchique.Souverains à Monaco et grands aristocrates en France, les Grimaldi constituent, au xviie siècle, des cabinets de curi...

On the errors in measurements of Ohio 5 radio sources in the light of the GB survey

International Nuclear Information System (INIS)

Machalski, J.

1975-01-01

Positions and flux densities of 405 OSU 5 radio sources surveyed at 1415 MHz down to 0.18 f.u. (Brundage et al. 1971) have been examined in the light of data from the GB survey made at 1400 MHz (Maslowski 1972). An identification analysis has shown that about 56% of OSU sources reveal themselves as single, 18% - as confused, 20% - as unresolved and 6% - having no counterparts in the GB survey down to 0.09 f.u. - seem to be spurious. The single OSU sources are strongly affected by the underestimation of their flux densities due to base-line procedure in their vicinity. The average value of about 0.03 f.u. has been found for the systematic underestimation. The second systematic error is due to the presence of a significant number of confused sources with strong overestimation of their flux densities. The confusion effect gives a characteristic non-Gaussian tail in the difference distribution between observed and real flux densities. The confusion effect has a strong influence on source counts from the OSU 5 survey. Differential number-counts relatively to that from the GB survey shows that the counts agree between themselves within the statistical uncertainty up to about 0.40 f.u., which is approximately 4 delta (delta - average rms flux density error in the OSU 5 survey). Below 0.40 f.u. the number of sources missing due to the confusion effect is significantly greater than the number-overestimation due to the noise error. Thus, this part of the OSU 5 source counts cannot be treated seriously, even in the statistical sense. An analysis of the approximate reliability and completeness of the OSU 5 survey shows that, although the total reliability estimated by the authors of the survey is good, the completeness is significantly lower due to the underestimation of the confusion effect magnitude. In fact, the OSU 5 completeness is 67% at 0.18 f.u. and 79% at 0.25 f.u. (author)

Les livres de recettes « francisés » au Mexique au XIXe siècle

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Sarah Bak-Geller Corona

2008-05-01

Full Text Available L’apparition des premiers livres de cuisine au Mexique - publiés par des maisons d’édition françaises spécialisées en ouvrages en espagnol - marque le début de l’histoire de la cuisine mexicaine. Cet événement s’inscrit par ailleurs dans une histoire plus large : celle de la construction de l’État-nation, entre nationalisme et cosmopolitisme. L’article s’intéresse aux idéaux de nation et de cuisine cohabitant dans deux des livres de recettes francisés du XIXe siècle au Mexique : l’Arte novísimo de cocina et le Nuevo cocinero americano/mexicano en forma de diccionario.French-fashioned Mexican recipe books in the 19th century. Globalization and construction of a national culinary modelThe first Mexican recipe books were published in the early 1830’s by French publishing houses specialized in Spanish written books. This article deals with the different nationalistic and cuisine models in two French-fashioned Mexican recipe books -the Arte novísimo de cocina and the Nuevo cocinero americano/mexicano en forma de diccionario- and their relationship with the nation-building context in nineteenth century Mexico.

Les scènes hivernales dans la peinture du Siècle d'or hollandais

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Martine Tabeaud

2010-10-01

Full Text Available Les scènes d'hiver connaissent leur apogée au Siècle d'or hollandais. En se focalisant sur les représentations de la neige et du froid, il est possible de voir s'il existe un lien entre ces tableaux et le climat de l'époque, voire une concomitance entre les types d'hiver réels et peints. Le succès de ces scènes d'hiver aidant, il apparaît que nombre de peintres ont fait fi du climat de l'époque et ont réalisé des scènes de genre hivernales, au point de créer une véritable imagerie. C'est ainsi que la rudesse des hivers de la période froide du Petit Âge Glaciaire a globalement disparu dans les représentations au profit d'hivers festifs.The winter scenesare at their optimum during the Dutch Golden Age. When one focuses on the winter and coldness representations, one might wonder if the paintings and the real weather are correlated. If they are, do the paintings genuinely show how the weather was when they were painted? As the winter scenes became appreciated, the painters started to paint without taking into account the real weather. Eventually they painted genre scenes of the winter time and almost developed a series of winter scenes' image. Therefore the unusual rough coldness of the Little Ice Age winters has generally disappeared of the paintings, joyful winter scenes being preferred.

Workshop for middle school and high school educators

International Nuclear Information System (INIS)

Miller, D.W.

1992-01-01

This paper summarizes the workshop entitled, 'Understanding and Teaching about Nuclear Technology and Its Place in Our Society' presented at Ohio State University (OSU) in August 1991. The workshop was a collaborative program with the American Nuclear Society (ANS) taking the lead and OSU taking a supportive and facilitator role. The paper addresses the issues of program management and development. Because the program elements provided by the ANS are generic to other workshops they have sponsored, only the unique contributions made by OSU are discussed

The Use of Substances Other Than Nicotine in Electronic Cigarettes Among College Students.

Science.gov (United States)

Kenne, Deric R; Fischbein, Rebecca L; Tan, Andy Sl; Banks, Mark

2017-01-01

Electronic cigarettes (e-cigarettes) have grown in popularity, especially among youth and young adults. Although e-cigarettes were originally intended to vaporize a liquid mixture containing nicotine, there appears to be an increasing trend in other substance use in e-cigarettes (OSUE). Cross-sectional data from 1542 undergraduate college student e-cigarette users from a large Midwestern university were collected via online survey to assess prevalence of e-cigarette use, reasons for use, perceived harm, and prevalence and predictors of OSUE. Nearly 7% (6.94%) reported using an e-cigarette to vaporize and inhale a substance other than nicotine. Current tobacco cigarette smokers were significantly more likely to report OSUE (51.0%) as compared with never (33.7%) and former (15.4%) smokers. Among respondents reporting OSUE, the primary reason for e-cigarette use was "safer than cigarettes" (21.7%), followed by "experimentation" (18.9%) and "friends use" (17.0%). Most (77.9%) reported using cannabis or some derivative of cannabis in an e-cigarette. Binomial logistic regression found that women were less likely to report OSUE by a factor of 0.60, former tobacco cigarette smokers as compared with never smokers were more likely to report OSUE by a factor of 1.87, and e-cigarette users who reported using e-cigarettes for "cool or trendy" reasons were more likely to report OSUE by a factor of 2.89. Little is known regarding the health effects of cannabis and cannabis derivatives delivered through e-cigarettes. Concern may also be warranted regarding the potential dangers of this young population using substances more dangerous than cannabis in e-cigarettes. Knowledge is limited regarding the public health impact of vaping cannabis or other illicit substances among college student populations. This study stresses the need for continued research regarding the vaping of cannabis and other illicit substances among college students.

Influência de substratos na formação dos porta-enxertos: limoeiro-Cravo (Citrus limonia Osbeck e tangerineira-Cleópatra (Citrus reshni Hort. Ex Tanaka em ambiente protegido

Directory of Open Access Journals (Sweden)

JABUR MARCOS ANTÔNIO

2002-01-01

Full Text Available Visando a estudar o efeito do substrato na produção de porta-enxertos de limoeiro-Cravo e tangerineira-Cleópatra em tubetes sob ambiente protegido, conduziu-se este trabalho na Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal-UNESP. O estudo foi realizado em ambiente coberto com sombrite preto sem proteção lateral, adotando-se delineamento inteiramente casualizado, em esquema fatorial 5x2, 4 repetições e 20 sementes por parcela. Utilizaram-se os substratos húmus de minhoca oriundo de esterco de curral (H% e vermiculita média (V%, sendo S1=H0 V100; S2=H25 V75; S3=H50 V50; S4=H75 V25 e S5=H100 V0. Avaliaram-se o número de plântulas emergidas, altura das plantas, diâmetro do caule, massas fresca e seca de raiz e parte aérea. Observaram-se resultados estatisticamente significativos para diâmetro do caule, aos 104 e 118 dias após a semeadura (DAS entre espécies, com superioridade de Cravo em relação a Cleópatra, porém não aos 132 DAS. Não foi constatada diferença significativa entre os substratos. Quanto à massa fresca de parte aérea, nenhuma diferença estatística ocorreu entre as espécies; porém, quanto aos substratos, S3 mostrou-se superior a S1, não diferindo, entretanto, dos demais. Embora a análise estatística não tenha mostrado diferenças significativas entre os tratamentos para os outros parâmetros analisados, S3 destacou-se entre os substratos testados.

NCBI nr-aa BLAST: CBRC-TTRU-01-0103 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-TTRU-01-0103 ref|YP_763917.1| HAAAP family serine permease [Francisella tulare...nsis subsp. holarctica OSU18] gb|ABI83280.1| HAAAP family serine permease [Francisella tularensis subsp. holarctica OSU18] YP_763917.1 0.077 25% ...

Cutaneous lupus erythematosus

DEFF Research Database (Denmark)

Biazar, Cyrus; Sigges, Johanna; Patsinakidis, Nikolaos

2013-01-01

) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures...

Oregon state university's advanced plant experiment (APEX) AP1000 integral facility test program

International Nuclear Information System (INIS)

Reyes, J.N.; Groome, J.T.; Woods, B.G.; Young, E.; Abel, K.; Wu, Q.

2005-01-01

Oregon State University (OSU) has recently completed a three year study of the thermal hydraulic behavior of the Westinghouse AP1000 passive safety systems. Eleven Design Basis Accident (DBA) scenarios, sponsored by the U.S. Department of Energy (DOE) with technical support from Westinghouse Electric, were simulated in OSU's Advanced Plant Experiment (APEX)-1000. The OSU test program was conducted within the purview of the requirements of 10CFR50 Appendix B, NQA-1 and 10 CFR 21 and the test data was used to provide benchmarks for computer codes used in the final design approval of the AP1000. In addition to the DOE certification testing, OSU conducted eleven confirmatory tests for the U.S. Nuclear Regulatory Commission. This paper presents the test program objectives, a description of the APEX-1000 test facility and an overview of the test matrix that was conducted in support of plant certification. (authors)

Paraître du deuil, d’un lieu à l’autre. Les veuves en Midi toulousain au XVIIIe siècle

Directory of Open Access Journals (Sweden)

Christine Dousset

2012-02-01

Full Text Available Sous l’Ancien Régime le veuvage oblige les femmes à changer d’apparence pour revêtir des habits de deuil, en particulier pendant l’année qui suit la mort du mari. À Toulouse, de la fin du XVIIe à la fin du XVIIIe siècle, se dessinent des permanences et des nouveautés qui apparaîtront de manière plus évidente dans la première partie du siècle suivant. L’importance symbolique de la tenue de la veuve est soulignée par l’obligation juridique faite aux héritiers du mari de lui fournir ses habits de deuil. Cependant, comme le montrent les inventaires après décès, les codes vestimentaires du deuil restent socialement discriminants, entre le respect d’une étiquette très élaborée par les veuves de la noblesse et les difficultés matérielles des femmes des milieux populaires urbains dont il est très difficile de préciser les pratiques. Ils se transforment cependant à la faveur des changements de la mode féminine et de la diffusion par l’imprimé, tel l’Almanach historique de la ville de Toulouse, du modèle parisien et curial dans les années 1780.Appearances of Mourning. The widows in Toulouse area in the Eighteenth century -During the "Ancien Regime", widowhood forced women to change their appearance to wear clothes of mourning, especially during the year following the death of their husband. In Toulouse, from the end of the Seventeenth century to the end of the Eightheenth century, we can see continuities and changes that will appear more prominently in the first part of the Nineteenth century. The legal obligation for the husband’s heirs to provide the widow’s « habits de deuil » shows the symbolic importance of mourning dress. However, as shown in the probate inventories, social groups use different mourning dress codes. The noble women must respect a very complicated etiquette whereas the women of the working classes are too poor and we don’t know exactly how they are dressed when they become

The Use of Substances Other Than Nicotine in Electronic Cigarettes Among College Students

Directory of Open Access Journals (Sweden)

Deric R Kenne

2017-09-01

Full Text Available Introduction: Electronic cigarettes (e-cigarettes have grown in popularity, especially among youth and young adults. Although e-cigarettes were originally intended to vaporize a liquid mixture containing nicotine, there appears to be an increasing trend in other substance use in e-cigarettes (OSUE. Materials and methods: Cross-sectional data from 1542 undergraduate college student e-cigarette users from a large Midwestern university were collected via online survey to assess prevalence of e-cigarette use, reasons for use, perceived harm, and prevalence and predictors of OSUE. Results: Nearly 7% (6.94% reported using an e-cigarette to vaporize and inhale a substance other than nicotine. Current tobacco cigarette smokers were significantly more likely to report OSUE (51.0% as compared with never (33.7% and former (15.4% smokers. Among respondents reporting OSUE, the primary reason for e-cigarette use was “safer than cigarettes” (21.7%, followed by “experimentation” (18.9% and “friends use” (17.0%. Most (77.9% reported using cannabis or some derivative of cannabis in an e-cigarette. Binomial logistic regression found that women were less likely to report OSUE by a factor of 0.60, former tobacco cigarette smokers as compared with never smokers were more likely to report OSUE by a factor of 1.87, and e-cigarette users who reported using e-cigarettes for “cool or trendy” reasons were more likely to report OSUE by a factor of 2.89. Discussion: Little is known regarding the health effects of cannabis and cannabis derivatives delivered through e-cigarettes. Concern may also be warranted regarding the potential dangers of this young population using substances more dangerous than cannabis in e-cigarettes. Knowledge is limited regarding the public health impact of vaping cannabis or other illicit substances among college student populations. This study stresses the need for continued research regarding the vaping of cannabis and other

Jet and electromagnetic tomography (JET) of extreme phases of matter in heavy-ion collisions

Energy Technology Data Exchange (ETDEWEB)

Heinz, Ulrich [The Ohio State Univ., Columbus, OH (United States)

2015-08-31

The Ohio State University (OSU) group contributed to the deliverables of the JET Collaboration three major products: 1. The code package iEBE-VISHNU for modeling the dynamical evolution of the soft medium created in relativistic heavy-ion collisions, from its creation all the way to final freeze-out using a hybrid approach that interfaces a free-streaming partonic pre-equilbrium stage with a (2+1)-dimensional viscous relativistic fluid dynamical stage for the quark-gluon plasma (QGP) phase and the microscopic hadron cascade UrQMD for the hadronic rescattering and freeze-out stage. Except for UrQMD, all dynamical evolution components and interfaces were developed at OSU and tested and implemented in collaboration with the Duke University group. 2. An electromagnetic radiation module for the calculation of thermal photon emission from the QGP and hadron resonance gas stages of a heavy-ion collision, with emission rates that have been corrected for viscous effects in the expanding medium consistent with the bulk evolution. The electromagnetic radiation module was developed under OSU leadership in collaboration with the McGill group and has been integrated in the iEBE-VISHNU code package. 3. An interface between the Monte Carlo jet shower evolution and hadronization codes developed by the Wayne State University (WSU), McGill and Texas A&M groups and the iEBE-VISHNU bulk evolution code, for performing jet quenching and jet shape modification studies in a realistically modeled evolving medium that was tuned to measured soft hadron data. Building on work performed at OSU for the theoretical framework used to describe the interaction of jets with the medium, initial work on the jet shower Monte Carlo was started at OSU and moved to WSU when OSU Visiting Assistant Professor Abhijit Majumder accepted a tenure track faculty position at WSU in September 2011. The jet-hydro interface was developed at OSU and WSU and tested and implemented in collaboration with the McGill, Texas

Impact de la forêt sur l’évolution des ressources en eau en moyenne montagne alpine depuis le milieu du XIXe siècle (massif de Chartreuse, France

Directory of Open Access Journals (Sweden)

Dominique Dumas

2012-02-01

Full Text Available Depuis la révolution industrielle, une grande partie des terres des espaces de moyenne montagne a été abandonnée au profit d’une extension de la couverture forestière. Or, la forêt intercepte et retient un pourcentage plus ou moins élevé des pluies sur son feuillage, diminuant du même coup la quantité d’eau réellement reçue par le sol. Le transfert de l’eau atmosphérique en une eau utilisable comme ressource a donc été progressivement modifié au cours de ces dernières décennies par la transformation progressive du paysage. Dans cette étude, conduite à l’échelle du massif de Chartreuse, la pluviométrie annuelle, le rôle de la forêt dans l’interception des pluies et l’extension de la forêt, sont appréciés tour à tour. L’impact de l’extension de la forêt depuis le milieu du XIXe siècle sur les quantités d’eau perdues pour l’écoulement et les réserves souterraines peut ainsi être évalué. Cette étude montre que, depuis le milieu du XIXe siècle, l’extension de la couverture forestière en Chartreuse aurait accru de presque 100 mm les pertes en eau par les processus d’interception. Et, sur cette même période, cette quantité d’eau perdue n’a pas été compensée par une hausse des précipitations. Au total, le bilan hydrologique a donc été notablement modifié, avec une quantité d’eau disponible pour l’écoulement, ou les réserves souterraines, plus réduite que celle définie traditionnellement à partir des uniques relevés météorologiques.

Analysis of photorefractive keratectomy (PRK) results at The Ohio State University

Science.gov (United States)

Roberts, Cynthia J.; Lembach, R. G.

1993-06-01

The Ohio State University (OSU) is one site of an FDA controlled investigational study to evaluate the safety and efficacy of excimer laser photorefractive keratectomy (PRK). This is a report of the current Phase III results at OSU for cases at 6 months post surgery as of 12/31/92.

Trading forest carbon - OSU

Science.gov (United States)

Issues associate with trading carbon sequestered in forests are discussed. Scientific uncertainties associated with carbon measurement are discussed with respect to proposed accounting procedures. Major issues include: (1) Establishing baselines. (2) Determining additivity from f...

OSU Chlorophyll Bloom Product

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This product was developed for the Oregon coast based on the observed change between running 8-day composite chlorophyll-a (CHL) data obtained by the MODerate...

L’industrie du luxe et la mode : du temps des créateurs au temps des communicants (fin XIXe, fin XXe siècle

Directory of Open Access Journals (Sweden)

Marc de Ferrière le Vayer

2007-05-01

Full Text Available En un siècle, le secteur de la mode en France a connu un profond bouleversement. D’un monde artisanal doté d’un grand savoir-faire, on est passé progressivement à une activité de grande production s’adressant à un marché de plus en plus large. Ainsi, les grands créateurs, tant dans la haute couture que dans le parfum, ont progressivement été remplacés par des designers touche à tout. Le marketing et la publicité deviennent les maîtres du secteur.Since the 19th century, the sector of French fashion economy has been deeply transformed. From a world of craftmen with a high know-how, it has moved to a world dominated by the industry and the mass market. The creators desappear one after another, and omnipotent designers supersede them. Today the luxury industry is ruled by marketing and advertising.

Représenter les lieux et les populations dans une colonie de peuplement: un siècle de recensements sud-africains / Mapping places and people in a settler society: From discrepancy to good fit over one century of South African censuses

Directory of Open Access Journals (Sweden)

Frédéric Giraut

2012-08-01

Full Text Available Depuis plus d'un siècle, l'Afrique du Sud a connu une remarquable série de recensements. Ceux-ci enregistrent la dynamique du peuplement dans le cadre de catégories socio-spatiales changeantes et liées aux représentations et projets successifs: coloniaux, d'apartheid et post-apartheid. Les premiers recensements proposaient une hiérarchisation des lieux typiques d'une colonie de peuplement. Le mouvement d'urbanisation, impliquant les populations non européennes, s'est traduit par l'évolution de la représentation officielle avec une reconnaissance progressive de localités autochtones. Sur un siècle, la géographie officielle des lieux de peuplement sud-africains est passée d'une perspective de société de pionniers à une perspective postcoloniale reconnaissant l'ensemble des communautés à travers leurs espaces.The dynamics of population and urbanization in South Africa have been recorded by a remarkable set of censuses during the 20th century. These censuses indicate a changing hierarchy of places that is typical of a settler society and of its representations of space and society. Over one century, the official census places and the pattern of population distribution have shifted from a selective colonial view of human settlements to an inclusive postcolonial society view closer to the distribution of the whole population.

La sodomie dans l’affaire Théophile de Viau : questions de genre et de sexualité dans la France du premier xviie siècle

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Matthieu Dupas

2010-04-01

Full Text Available L’affaire Théophile est source de malentendus. Alors que l’historiographie du libertinage, en se concentrant sur le libertinage érudit a fini par oublier que la sodomie était un enjeu majeur du procès, les historiens de la répression homosexuelle abordent les relations sexuelles entre hommes dans une perspective essentialiste, gommant toute distinction entre sodomie au xviie siècle et homosexualité à l’époque contemporaine. Il s’agit donc la première partie de cet article de souligner que la sodomie est au cœur de l’affaire à la fois comme objet de représentation littéraire et comme pratique illicite. La seconde partie consiste dans une historicisation des discours ayant trait aux relations sexuelles entre hommes, qui montre qu’on ne saurait confondre « homosexualité masculine » et « sodomie ». Celle-ci désigne en effet des rapports anaux aussi bien entre hommes et femmes qu’entre hommes seuls ; lorsque la notion est mobilisée pour renvoyer à des relations anales entre hommes, elle ne constitue pas pour autant une orientation sexuelle ; en tant que concept issu de la théologie, elle ne relève pas de la sexualité ; aucune déviation de genre ne lui est associée. Dans une troisième partie, il s’agit de montrer que la notion de sodomie ne doit pas nous conduire à ignorer les autres discours pouvant porter sur les relations sexuelles entre hommes dans la France du premier xviie siècle et qu’à ce titre, on ne saurait se suffire de cette catégorie pour aborder la question. Bref, cet article a pour but de poser les premiers jalons d’une histoire de l’homosexualité masculine dans la France du xviie siècle d’un point de vue historiciste, sinon constructionniste.Sodomy in the Theophile de Viau affair: questions of gender and sexuality in early modern France.There is a puzzling misunderstanding about the Theophile affair. While the historiography of libertinism, focusing on erudite

Attenuated Neural Processing of Risk in Young Adults at Risk for Stimulant Dependence.

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Martina Reske

Full Text Available Approximately 10% of young adults report non-medical use of stimulants (cocaine, amphetamine, methylphenidate, which puts them at risk for the development of dependence. This fMRI study investigates whether subjects at early stages of stimulant use show altered decision making processing.158 occasional stimulants users (OSU and 50 comparison subjects (CS performed a "risky gains" decision making task during which they could select safe options (cash in 20 cents or gamble them for double or nothing in two consecutive gambles (win or lose 40 or 80 cents, "risky decisions". The primary analysis focused on risky versus safe decisions. Three secondary analyses were conducted: First, a robust regression examined the effect of lifetime exposure to stimulants and marijuana; second, subgroups of OSU with >1000 (n = 42, or <50 lifetime marijuana uses (n = 32, were compared to CS with <50 lifetime uses (n = 46 to examine potential marijuana effects; third, brain activation associated with behavioral adjustment following monetary losses was probed.There were no behavioral differences between groups. OSU showed attenuated activation across risky and safe decisions in prefrontal cortex, insula, and dorsal striatum, exhibited lower anterior cingulate cortex (ACC and dorsal striatum activation for risky decisions and greater inferior frontal gyrus activation for safe decisions. Those OSU with relatively more stimulant use showed greater dorsal ACC and posterior insula attenuation. In comparison, greater lifetime marijuana use was associated with less neural differentiation between risky and safe decisions. OSU who chose more safe responses after losses exhibited similarities with CS relative to those preferring risky options.Individuals at risk for the development of stimulant use disorders presented less differentiated neural processing of risky and safe options. Specifically, OSU show attenuated brain response in regions critical for performance monitoring

The History of Women in Botany and Science at the Herbarium Library: Evaluation for Historical Research.

Science.gov (United States)

Wicker, Sandra J.

Evaluating library collections by comparing them to bibliographies has a long history in research libraries. This evaluative study examined all 107 titles within the "Women in Botany" section of the Herbarium Library at The Ohio State University (OSU). The Herbarium is not part of the OSU Library system, but functions as a satellite to…

Armes et Armures dans l'Oeuvre Épique et Historique de Jean d'Outremeuse (XIV^e Siècle

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Gaier, Claude

1983-12-01

Full Text Available JEAN d'Outremeuse fut et reste le plus populaire des vieux auteurs qui ont écrit l'histoire de l'ancienne principauté de Liège. Cette notoriété, il la doit sans doute à l'usage de la langue vulgaire -un français teinté de wallon- et aussi à l'extraordinaire profusion de détails pitttoresques qui émaillent ses narrations, où vingt générations d'érudits, de littérateurs et d'échotiers du passé ont puisé leur inspiration. Pourtant, la critique historique de notre siècle n'a eu aucune peine à démontrer que pareil ascendant n'était pas mérité, puisque Jean d'Outremeuse avait bel et bien recopié d'autres récits ou inventé de toutes pièces la matière qu'il n'avait pas trouvée dans des sources antérieures. De sorte que, à quelques nuances près, l'admiration sans bornes qu'on lui vouait jadis à désormais cédé la place au scepticisme, voire au dénigrement systématique à son égard.

The Hale Effect

Science.gov (United States)

Gray, Katti

2012-01-01

Ohio State University's (OSU) Frank W. Hale Jr. Black Cultural Center is a rarity in academia, as was its namesake. When OSU named its standout Black cultural center after the civil rights activist, professor and vice provost who championed such a place, it was commemorating what Dr. Frank W. Hale Jr. stood for. He promoted academic rigor, those…

Exempla et sentences des Antiques dans la littérature politique du XVe siècle en Castille

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Béatrice Leroy

2013-06-01

Full Text Available La communication se propose d’analyser les principaux traités de Diego de Valera (Défense des Femmes Vertueuses, Miroir de Véritable Noblesse, Doctrinal des Princes ; la Suma de Política de Rodrigo Sánchez de Arevalo ; les Claros Varones de Castilla d’Hernando del Pulgar. Ces trois auteurs du XVe siècle castillan citent, autant ou plus que les textes des Testaments et la littérature ecclésiastique, les philosophes et les historiens grecs et latins, tirant de leurs exempla et de leurs conclusions des leçons de bon gouvernement, de comportement social et politique, de sagesse et de moralité.La comunicación se propone analizar los principales tratados de Diego de Valera (la Defensa de las virtuosas mujeres, el Espejo de verdadera nobleza, y el Doctrinal de príncipes ; la Suma de Política de Rodrigo Sánchez de Arévalo ; los Claros Varones de Castilla de Hernando del Pulgar. Estos tres autores del siglo XV castellano citan, tanto y más que los textos de los Testamentos y la literatura eclesiástica, los filósofos e historiadores griegos y latinos, sacando de sus ejemplos y de sus conclusiones lecciones de buen gobierno, de comportamiento social y político, de sabiduría y moralidad.

Flexible Spectral Imaging Color Enhancement and Probe-based Confocal Laser Endomicroscopy in Minimal Change Esophageal Reflux Disease.

Science.gov (United States)

Pittayanon, Rapat; Aumkaew, Surasak; Rerknimitr, Rungsun; Wisedopas, Naruemon; Kullavanijaya, Pinit

2016-07-25

Although flexible spectral imaging color enhancement (FICE) can facilitate the diagnosis of minimal change esophageal reflux disease (MERD), the complicated diagnostic criteria cause suboptimal inter-observer agreement. Confocal laser endomicroscopy (CLE) yields good diagnostic results but its inter-observer agreement has never been explored. This study compares the diagnostic value of magnifying FICE and probe-based CLE (pCLE) for MERD and evaluates the inter-observer agreement of both techniques. Thirty-six patients with suspected MERD and 18 asymptomatic controls were recruited. Magnifying FICE was used for evaluation of distal esophagus. pCLE counted the number of intrapapillary capillary loops (IPCLs) using more than five IPCLs in 500×500 micron area as a criterion for MERD diagnosis. The validity scores and interobserever agreement of both FICE and pCLE were assessed. For FICE vs. pCLE, the accuracy was 79% vs. 87%, sensitivity 94% vs. 97%, specificity 50% vs. 66%, positive predictive value 79% vs. 85%, and negative predictive value 82% vs. 92%. Interobserver agreement of FICE was fair to substantial, whereas pCLE had substantial to almost perfect agreement. Both FICE and pCLE have good operating characteristics and can facilitate the MERD diagnosis. However, among different observers, pCLE is more consistent on MERD diagnosis.

University Reactor Instrumentation grant program. Final report, September 7, 1990--August 31, 1995

International Nuclear Information System (INIS)

Talnagi, J.W.

1998-01-01

The Ohio State University Nuclear Reactor Laboratory (OSU NRL) participated in the Department of Energy (DOE) grant program commonly denoted as the University Reactor Instrumentation (URI) program from the period September 1990 through August 1995, after which funding was terminated on a programmatic basis by DOE. This program provided funding support for acquisition of capital equipment targeted for facility upgrades and improvements, including modernizing reactor systems and instrumentation, improvements in research and instructional capabilities, and infrastructure enhancements. The staff of the OSU NRL submitted five grant applications during this period, all of which were funded either partially or in their entirety. This report will provide an overview of the activities carried out under these grants and assess their impact on the OSU NRL facilities

The responses of net primary production (NPP) and total carbon storage for the continental United States to changes in atmospheric CO{sub 2}, climate, and vegetation

Energy Technology Data Exchange (ETDEWEB)

McGuire, D.A. [Marine Biological Lab., Woods Hole, MA (United States)

1995-06-01

We extrapolated 3 biogeochemistry models (BIOME-BGC, CENTURY, and TEM) across the continental US with the vegetation distributions of 3 biogeography models (BIOME2, DOLY, and MAPSS) for contemporary climate at 355 ppmv CO{sub 2} and each of 3 GCM climate scenarios at 710 ppmv. For contemporary conditions, continental NPP ranges from 3132 to 3854 TgC/yr and total carbon storage ranges from 109 to 125 PgC. The responses of NPP range from no response (BIOME-BGC with DOLY or MAPSS vegetations for UKMO climate) to increases of 53% and 56% (TEM with BIOME2 vegetations for GFDL and OSU climates). The responses of total carbon storage vary from a decrease of 39% (BIOME-BGC with MAPSS vegetation for UKMO climate) to increases of 52% and 56% (TEM with BIOME2 vegetations for OSU and GFDL climates). The UKMO responses of BIOME-BGC with MAPSS vegetation are caused by both decreased forest area (from 44% to 38%) and photosynthetic water stress. The OSU and GFDL responses of TEM with BIOME2 vegetations are caused by forest expansion (from 46% to 67% for OSU and to 75% for GFDL) and increased nitrogen cycling.

Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Cutaneous Lupus Erythematosus: A Population-Based Cohort Study.

Science.gov (United States)

Singh, Abha G; Crowson, Cynthia S; Singh, Siddharth; Denis, Mark; Davis, P; Maradit-Kremers, Hilal; Matteson, Eric L; Chowdhary, Vaidehi R

2016-11-01

It is unclear whether isolated cutaneous lupus erythematosus (CLE) affects cardiovascular risk. We estimated the cumulative incidence and mortality of cardiovascular diseases in a population-based CLE cohort and compared the risk with a matched non-CLE cohort. All incident cases of CLE in Olmsted County, Minnesota, between 1965 and 2005 were followed until December 2013. The cumulative incidence of cerebrovascular accidents (CVAs [including stroke and transient ischemic attack]), ischemic heart disease (IHD [including coronary artery disease, myocardial infarction, and angina pectoris]), heart failure, and peripheral arterial disease (PAD) was derived and compared to an age-, sex-, and calendar year-matched non-CLE cohort using Cox models. There were 155 patients with CLE (mean ± SD age at diagnosis 48 ± 16 years, 65% female, mean ± SD BMI 26.3 ± 7.1 kg/m 2 , 40% smokers, 9% with diabetes mellitus). During a median followup of 14.6 years, 41 CLE patients had cardiovascular events (15 patients with CVAs, 32 patients with IHD), with a 20-year cumulative incidence of 31.6%. As compared to non-CLE subjects, the risk of CVAs (smoking-adjusted hazard ratio [HR] 2.97 [95% confidence interval (95% CI) 1.13-7.78]) and PAD (HR 2.06 [95% CI 0.99-4.32]) was increased in patients with CLE, but the risk of IHD was not increased (HR 0.94 [95% CI 0.57-1.54]). There was no increase in cardiovascular mortality (HR 1.68 [95% CI 0.76-3.75]). The magnitude of risk for any cardiovascular outcome was not significantly influenced by the extent of cutaneous involvement. CLE may be associated with an increased risk of CVAs and PAD, but not IHD. Factors contributing to increased CVA risk in patients with CLE merit evaluation. © 2016, American College of Rheumatology.

NCBI nr-aa BLAST: CBRC-CBRI-05-0288 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-CBRI-05-0288 ref|YP_512974.1| Acyltransferase [Francisella tularensis subsp. h...olarctica] ref|YP_762841.1| acyltransferase [Francisella tularensis subsp. holarctica OSU18] ref|YP_001427626.1| acyltransferase [Fra...ncisella tularensis subsp. holarctica FTA] emb|CAJ78620.1| Acyltransferase [Francis...ella tularensis subsp. holarctica LVS] gb|ABI82204.1| acyltransferase [Francisell...a tularensis subsp. holarctica OSU18] gb|EBA51928.1| acyltransferase [Francisella tularensis subsp. holarcti

Purchase of Journal Portfolios by Research Libraries is not Cost-Effective and May Lead to Normalization of Collections. A Review of: Murphy, Sarah Ann. “The Effects of Portfolio Purchasing on Scientific Subject Collections.” College & Research Libraries July 2008: 332-40.

Directory of Open Access Journals (Sweden)

Stephanie Walker

2009-03-01

Full Text Available Objectives – To determine whether the purchase of journal portfolios (i.e., packages of journals purchased as a group from publishers, such as Elsevier’s ScienceDirect from publishers is an effective means of meeting research needs for faculty in the life, medical, physical, and applied sciences, and to determine the effects of such purchases on research library collections.Design – Citation analysis.Setting – Ohio State University libraries in the life, medical, physical, and applied sciences.Subjects – A total of 253,604 citations from 6,815 articles published between the years 2003 and 2005 by Ohio State University faculty in the life, medical, physical, and applied sciences were analyzed using the Bradford distribution (an explanation of the Bradford Distribution is provided later in this review.Methods – Using ISI’s Science Citation Index,the author generated a list of articles published by Ohio State University (OSU faculty in the life, medical, physical, and applied sciences between the years 2003 and 2005. The author then assigned each article to a specific discipline, according to the OSU College of the first OSU author listed. For example, if an article was written by several co-authors, and the first OSU author listed was a faculty member in OSU’s College of Dentistry, the article would be designated a Dentistry article. Multi-disciplinary works were assigned to the college of the first OSU author listed. (The OSU Colleges considered to be part of the study were the College of Biological Sciences; the College of Dentistry; the College of Engineering; Food, Agriculture, and Environmental Sciences; the College of Mathematical and Physical Sciences; the College of Medicine; the College of Optometry; the College of Pharmacy; and the College of Veterinary Medicine. Books, conference proceedings, theses, and other non-journal materials were excluded from the set of citations considered. Next, the author pulled journal

Wagnerianos, flâneurs, hombres-masa. Los ambientes sinestésicos en la arquitectura fin-de-siècle

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Eduardo Prieto

2014-10-01

Full Text Available Con su énfasis en la contaminación entre las disciplinas, así como en el papel que otorgan a la integración de los sentidos humanos en la percepción del espacio, las investigaciones contemporáneas sobre las “atmósferas” habitadas tienen un antecedente apenas señalado por la historiografía: la arquitectura fin-de-siècle. En la Francia de finales del siglo XIX la sinestesia se convierte en un tema de moda que, procedente de la recién fundada estética psicológica, pronto desbordará sus primitivos límites para alcanzar la arquitectura; en Alemania, por su parte, la noción romántica de la Gesamtkunstwerk encontrará en el teatro de Wagner un nuevo campo donde las artes colaborarán para producir sorprendes ambientes oníricos. En paralelo, la percepción sinestésica se transformará en el leitmotiv de las instalaciones concebidas para el disfrute multisensorial de los miembros de una incipiente cultura de masas, y dará pie a arquitecturas tan lúdicas como técnica­mente sofisticadas: las construcciones para ferias internacionales. Los ambientes sinestésicos para flâneurs, wagnerianos y hombres-masa serán, así, el germen de los pabellones electroacústicos de Le Corbusier, Iannis Xenakis o Charles y Ray Eames, y de las experiencias de integración ambiental entre las artes propias de Jean Labatut, Charles Moore y, en general, buena parte de las vanguardias de las décadas de 1950 y 1960.

OSU VIIRS Chla Bloom Product

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This product was developed for the Oregon coast based on the observed change between running 8-day composite chlorophyll-a (CHL) data obtained by the VIIRS aboard...

Mimic of OSU research reactor

International Nuclear Information System (INIS)

Lu, Hong; Miller, D.W.

1991-01-01

The Ohio State University research reactor (OSURR) is undergoing improvements in its research and educational capabilities. A computer-based digital data acquisition system, including a reactor system mimic, will be installed as part of these improvements. The system will monitor the reactor system parameters available to the reactor operator either in digital parameters available to the reactor operator either in digital or analog form. The system includes two computers. All the signals are sent to computer 1, which processes the data and sends the data through a serial port to computer 2 with a video graphics array VGA monitor, which is utilized to display the mimic system of the reactor

OSU MODIS FLH Bloom Product

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Two bloom products were developed for the Oregon coast based on the observed change between running 8-day composite chlorophyll-a (CHL) and fluorescence line-height...

Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.

Science.gov (United States)

Menke, Julia; Hsu, Mei-Yu; Byrne, Katelyn T; Lucas, Julie A; Rabacal, Whitney A; Croker, Byron P; Zong, Xiao-Hua; Stanley, E Richard; Kelley, Vicki R

2008-11-15

Sunlight (UVB) triggers cutaneous lupus erythematosus (CLE) and systemic lupus through an unknown mechanism. We tested the hypothesis that UVB triggers CLE through a CSF-1-dependent, macrophage (Mø)-mediated mechanism in MRL-Fas(lpr) mice. By constructing mutant MRL-Fas(lpr) strains expressing varying levels of CSF-1 (high, intermediate, none), and use of an ex vivo gene transfer to deliver CSF-1 intradermally, we determined that CSF-1 induces CLE in lupus-susceptible MRL-Fas(lpr) mice, but not in lupus-resistant BALB/c mice. UVB incites an increase in Møs, apoptosis in the skin, and CLE in MRL-Fas(lpr), but not in CSF-1-deficient MRL-Fas(lpr) mice. Furthermore, UVB did not induce CLE in BALB/c mice. Probing further, UVB stimulates CSF-1 expression by keratinocytes leading to recruitment and activation of Møs that, in turn, release mediators, which induce apoptosis in keratinocytes. Thus, sunlight triggers a CSF-1-dependent, Mø-mediated destructive inflammation in the skin leading to CLE in lupus-susceptible MRL-Fas(lpr) but not lupus-resistant BALB/c mice. Taken together, CSF-1 is envisioned as the match and lupus susceptibility as the tinder leading to CLE.

Sunlight Triggers Cutaneous Lupus through a Colony Stimulating Factor-1 (CSF-1) Dependent Mechanism in MRL-Faslpr mice

Science.gov (United States)

Menke, Julia; Hsu, Mei-Yu; Byrne, Katelyn T.; Lucas, Julie A.; Rabacal, Whitney A.; Croker, Byron P.; Zong, Xiao-Hua; Stanley, E. Richard; Kelley, Vicki R.

2008-01-01

Sunlight (UVB) triggers cutaneous (CLE) and systemic lupus through an unknown mechanism. We tested the hypothesis that UVB triggers CLE through a CSF-1-dependent, macrophage (Mø) -mediated mechanism in MRL-Faslpr mice. By constructing mutant MRL-Faslpr strains expressing varying levels of CSF-1 (high, intermediate, none), and use of an ex-vivo gene transfer to deliver CSF-1 intra-dermally, we determined that CSF-1 induces CLE in lupus-susceptible, MRL-Faslpr mice, but not in lupus-resistant, BALB/c mice. Notably, UVB incites an increase in Mø, apoptosis in the skin and CLE in MRL-Faslpr, but not in CSF-1-deficient MRL-Faslpr mice. Furthermore, UVB did not induce CLE in BALB/c mice. Probing further, UVB stimulates CSF-1 expression by keratinocytes leading to recruitment and activation of Mø that, in turn, release mediators, which induce apoptosis in keratinocytes. Thus, sunlight triggers a CSF-1-dependent, Mø-mediated destructive inflammation in the skin leading to CLE in lupus-susceptible MRL-Faslpr, but not lupus-resistant BALB/c mice. Taken together, we envision CSF-1 as the “match” and lupus-susceptibility as the “tinder” leading to CLE. PMID:18981160

Recenser et étudier le patrimoine religieux du XXe siècle : l’exemple de l’inventaire des églises du Nord-Pas-de-Calais (1945-2000

Directory of Open Access Journals (Sweden)

Céline Frémaux

2009-11-01

Full Text Available La seconde moitié du XXe siècle fut une période de mutation accélérée de l’architecture religieuse en France. L’inventaire des églises paroissiales reconstruites et construites dans la région Nord-Pas-de-Calais entre 1945 et 2000 en reflète les divers aspects. Le corpus de 183 églises servant de base à une thèse de doctorat révèle l’effort d’adaptation de l’Église aux mutations historiques, économiques et sociales de cette périodeThe second half of the 20th century was a time of tumultuous changes in French religious architecture. The survey of parish churches built in the Nord-Pas-de-Calais region between 1945 and 2000 reflects all these changes. The corpus of 183 churches, on which a thesis has been based, reveals the church’s ability as an institution to adapt to the historical, economic and social changes of its time.

Spin-Polarized Scanning Tunneling Microscope for Atomic-Scale Studies of Spin Transport, Spin Relaxation, and Magnetism in Graphene

Science.gov (United States)

2017-11-09

Polarized Scanning Tunneling Microscope for Atomic-Scale Studies of Spin Transport, Spin Relaxation, and Magnetism in Graphene Report Term: 0-Other Email ...Principal: Y Name: Jay A Gupta Email : gupta.208@osu.edu Name: Roland K Kawakami Email : kawakami.15@osu.edu RPPR Final Report as of 13-Nov-2017...studies on films and devices. Optimization of the Cr tip will be the next important step to establish this technique. We are writing up these early

A Rationally Designed Histone Deacetylase Inhibitor with Distinct Antitumor Activity against Ovarian Cancer

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Ya-Ting Yang

2009-06-01

Full Text Available Histone deacetylase inhibitors (HDACIs are a class of antineoplastic agents previously demonstrating preclinical chemosensitizing activity against drug-resistant cancer cells and mouse xenografts. However, whereas clinical studies have shown efficacy against human hematologic malignancies, solid tumor trials have proved disappointing. We previously developed a novel HDACI, “OSU-HDAC42,” and herein examine its activity against ovarian cancer cell lines and xenografts. OSU-HDAC42, (i unlike most HDACIs, elicited a more than five-fold increase in G2-phase cells, at 2.5 µM, with G2 arrest followed by apoptosis; (ii at 1.0 µM, completely repressed messenger RNA expression of the cell cycle progression gene cdc2; (iii at low doses (0.25–1.0 µM for 24 hours, induced tumor cell epithelial differentiation, as evidenced by morphology changes and a more than five-fold up-regulation of epithelium-specific cytokeratins; (iv potently abrogated the growth of numerous ovarian cancer cells, with IC50 values of 0.5 to 1.0 µM, whereas also remaining eight-fold less toxic (IC50 of 8.6 µM to normal ovarian surface epithelial cells; and (v chemosensitizated platinum-resistant mouse xenografts to cisplatin. Compared with the clinically approved HDACI suberoylanilide hydroxamic acid (vorinostat, 1.0 µM OSU-HDAC42 was more biochemically potent (i.e., enzyme-inhibitory, as suggested by greater gene up-regulation and acetylation of both histone and nonhistone proteins. In p53-dysfunctional cells, however, OSU-HDAC42 was two- to eight-fold less inductive of p53-regulated genes, whereas also having a two-fold higher IC50 than p53-functional cells, demonstrating some interaction with p53 tumor-suppressive cascades. These findings establish OSU-HDAC42 as a promising therapeutic agent for drug-resistant ovarian cancer and justify its further investigation.

Ergospirometry with concurrent fibre optic laryngoscopy

DEFF Research Database (Denmark)

Mirza, Kiran Kafila; Walsted, Emil Schwarz; Backer, Vibeke

2017-01-01

in VO2max measured by ergospirometry with and without simultaneous continuous laryngoscopy during exercise (CLE) testing (mean difference -22 ml O2･min-1; 95% CI -125 to 81 ml O2･min-1; P = 0.647). EILO scores obtained during the CLE testing on the treadmill versus CLE testing on the ergometer bike...... individuals, ergospirometry with laryngoscopy is feasible and well tolerated, yielding measurements for maximal oxygen uptake comparable to those of standard bike ergospirometry. Likewise, measurements of supraglottic EILO are comparable to those of the standard treadmill CLE test....

Conversion et culture dans le monde grec du IVe siècle ap. J.-C. Conversion and culture in the 4th century AD Greek world

Directory of Open Access Journals (Sweden)

Pierre-Louis Malosse

2009-10-01

Full Text Available Rarement la conversion – concept, événement, acte – a tenu une place telle qu’au IVe siècle après Jésus-Christ, dans les années qui mènent de la conversion d’un empereur (Constantin à celle de l’empire. Dans le monde oriental, dominé par la culture hellénique, la conversion religieuse rencontre un modèle depuis longtemps reconnu, celui de la conversion philosophique (ou à la philosophie. Entre l'une et l'autre, il existe une certaine porosité, plus ou moins consciente, comme l'attestent en des directions opposées le cas des milieux philosophiques alexandrins – y compris peut-être Arios –, ou celui de Julien. D'autre part, à l'orée du IVe siècle, la conversion chrétienne a déjà une longue histoire. La nouveauté de l'Antiquité tardive, outre le changement d'échelle, du petit nombre à la masse et du marginal à l'officiel avec le soutien de l'État, est de poser la question du rapport de la conversion religieuse à la culture traditionnelle, question qui ne se posait pas à propos de la conversion philosophique, puisque celle-ci était une composante de cette culture, question qui se pose particulièrement au moment où les convertis prétendent prendre en charge la culture. Plus précisément, il s'agit d'une confrontation avec la paideia, concept qui embrasse et unit étroitement culture et éducation. Chez les auteurs qui s’y réfèrent, que ce soit explicitement ou implicitement, la conversion se définit par rapport à la paideia tour à tour en termes d’exclusion, de concurrence et de complémentarité.Conversion –as a concept, as an event and as a deed – was seldom as imporant as it was during Forth Century AD, from the conversion of an emperor (Constantine to the conversion of the whole Empire. In the Greek speaking and thinking East, religious conversion came across philosophical conversion model, which had been known and admitted for a long time. So, philosophical conversion could

Problems connected with the production of highly specific antisera against prostaglandin E2 (PGE2) and prostaglandin A2 (PGA2) for radioimmunoassay

International Nuclear Information System (INIS)

Kopp, H.G.; Vetter, W.; Siegenthaler, W.

1978-01-01

To obtain sensitive and specific antisera against PGE 2 and PGA 2 these substances were coupled to thyroglobulin (Tg). Coupling reactions were performed by using either a hydroxy-succinimide-ester as intermediate step leading to a complex carrying 170mol PGE 2 per mol Tg (''PGE 2 -OSU-Tg'') and 240mol PGA 2 per mol Tg (''PGA 2 -OSU-Tg''), or N, N'-carbonyl-diimidazole resulting in ''PGE 2 -CDI-Tg'' (400mol PGE 2 per mol Tg) and ''PGA 2 -CDI-Tg'' (600mol PGA 2 per mol Tg). Two tracer systems ( 3 H-prostaglandin and 125 I-histamine-prostaglandin) were used for analysis of antibody activity. The PGE 2 -CDI-Tg and PGA 2 -CDI-Tg complexes were both poor immunogens in rabbits. The PGE 2 -OSU-Tg and PGA 2 -OSU-Tg conjugates were injected in rabbits and in guinea-pigs. These two compounds resulted in very high antibody titres in both animal species. However, in guinea-pigs a markedly higher antibody sensitivity and antibody specificity were observed than in rabbits. Our results indicate that the guinea-pig may be the animal of choice for immunization against prostaglandins. Antibody specificity of guinea-pig antisera may be high enough to measure the concentration of PGE 2 and PGA 2 in the presence of other prostaglandins or prostaglandin metabolites. (author)

Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis.

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Robles-Medranda, Carlos; Vargas, Maria; Ospina, Jesenia; Puga-Tejada, Miguel; Valero, Manuel; Soria, Miguel; Bravo, Gladys; Robles-Jara, Carlos; Lukashok, Hannah Pitanga

2017-08-16

To evaluate the clinical impact of confocal laser endomicroscopy (CLE) in the diagnosis and management of patients with an uncertain diagnosis. A retrospective chart review was performed. Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included. Baseline characteristics, indications, previous diagnostic studies, findings at the time of CLE, clinical management and histological results were analyzed. Interventions based on CLE findings were also analyzed. We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens. A total of 144 patients were included. Of these, 51% (74/144) were female. The mean age was 51 years old. In all, 41/144 (28.4%) lesions were neoplastic (13 bile duct, 10 gastric, 8 esophageal, 6 colonic, 1 duodenal, 1 rectal, 1 ampulloma and 1 pancreatic). The sensitivity, specificity, positive predictive value, negative predictive value, and observed agreement when CLE was used to detect N-lesions were 85.37%, 87.38%, 72.92%, 93.75% and 86.81%, respectively. Cohen's Kappa was 69.20%, thus indicating good agreement. Changes in management were observed in 54% of the cases. CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis.

BRANCHES - Église paroissiale Saint-Martin - (canton d’Aillant-sur-Tholon

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2010-08-01

Full Text Available Interventions (2002-2009Une série d’interventions ont eu lieu dans l’église de Branches dans le cadre de stage d’analyse du bâti – relevés architecturaux et de peintures murales – organisé par le CEM, sous les responsabilités de Gilles Fèvre et de Carlos Castillo.DescriptionLe siteLe site est mentionné dès le viie siècle (GPA. Un prieuré-cure est fondé au xiiie siècle (GPA.L’église date du xiiie siècle. Elle a été remaniée au xvie siècle et en partie refaite à la fin du xviiie siècle (faça...

Population Pharmacokinetics of Hydroxychloroquine in Japanese Patients With Cutaneous or Systemic Lupus Erythematosus.

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Morita, Shigemichi; Takahashi, Toshiya; Yoshida, Yasushi; Yokota, Naohisa

2016-04-01

Hydroxychloroquine (HCQ) is an effective treatment for patients with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) and has been used for these patients in more than 70 nations. However, in Japan, HCQ has not been approved for CLE or SLE. To establish an appropriate therapeutic regimen and to clarify the pharmacokinetics (PK) of HCQ in Japanese patients with CLE with or without SLE (CLE/SLE), a population pharmacokinetic (PopPK) analysis was performed. In a clinical study of Japanese patients with a diagnosis of CLE irrespective of the presence of SLE, blood and plasma drug concentration-time data receiving multiple oral doses of HCQ sulfate (200-400 mg daily) were analyzed using nonlinear mixed-effects model software. The blood and plasma concentrations of HCQ were analyzed using a high-performance liquid chromatography tandem mass spectrometry method. Model evaluation and validation were performed using goodness-of-fit (GOF) plots, visual predictive check, and a bootstrap. The PopPKs of HCQ in the blood and plasma of 90 Japanese patients with CLE/SLE were well described by a 1-compartment model with first-order absorption and absorption lag time. Body weight was a significant (P < 0.001) covariate of oral clearance of HCQ. The final model was assessed using GOF plots, a bootstrap, and visual predictive check, and this model was appropriate. Simulations based on the final model suggested that the recommended daily doses of HCQ sulfate (200-400 mg) based on the ideal body weight in Japanese patients with CLE/SLE were in the similar concentration ranges. The PopPK models derived from both blood and plasma HCQ concentrations of Japanese patients with CLE/SLE were developed and validated. Based on this study, the dosage regimens of HCQ sulfate for Japanese patients with CLE/SLE should be calculated using the individual ideal body weight.

Isotopic variants of light and heavy L-pyroglutamic acid succinimidyl esters as the derivatization reagents for DL-amino acid chiral metabolomics identification by liquid chromatography and electrospray ionization mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

Mochizuki, Toshiki; Todoroki, Kenichiro; Inoue, Koichi; Min, Jun Zhe; Toyo’oka, Toshimasa, E-mail: toyooka@u-shizuoka-ken.ac.jp

2014-02-06

Graphical abstract: -- Highlights: •Isotopic variants of chiral labeling reagents were newly synthesized. •Analysis of DL-amino acids was performed by UPLC–ESI–MS/MS. •Highly efficient enantioseparation and detection of DL-amino acids were performed. •Differential analysis of DL-amino acid was successfully performed in real samples. -- Abstract: L-Pyroglutamic acid succinimidyl ester (L-PGA-OSu) and its isotopic variant (L-PGA[d{sub 5}]-OSu) were newly synthesized and evaluated as the chiral labeling reagents for the enantioseparation of amino acids, in terms of separation efficiency by reversed-phase chromatography and detection sensitivity by ESI-MS/MS. The enantiomers of amino acids were easily labeled with the reagents at 60 °C within 10 min in an alkaline medium containing triethylamine. Although all the diastereomers derived from 18 proteolytic amino acids could not be satisfactorily separated, the pairs of 9 amino acids were completely separated by reversed-phase chromatography using the small particle (1.7 μm) ODS column (Rs = 1.95–8.05). The characteristic daughter ions, i.e., m/z 84.04 and m/z 89.04, were detected from all the derivatives by the collision induced dissociation of the protonated molecular ions. A highly sensitive detection at a low-fmol level (0.5–3.2 fmol) was also obtained from the selected reaction monitoring (SRM) chromatograms. An isotope labeling strategy using light and heavy L-PGA-OSu for the differential analysis of the DL-amino acids in different sample groups is also presented in this paper. The differential analysis of biological sample (i.e., human serum) and food product (i.e., yogurt) were tried to demonstrate the efficiency of the proposed method. The ratios of the DL-amino acids in human serum samples, spiked with the different concentrations of D-amino acids, were determined by the procedures using L-PGA-OSu and L-PGA[d{sub 5}]-OSu. The D/L ratios in the two sample groups at different concentrations of

Isotopic variants of light and heavy L-pyroglutamic acid succinimidyl esters as the derivatization reagents for DL-amino acid chiral metabolomics identification by liquid chromatography and electrospray ionization mass spectrometry

International Nuclear Information System (INIS)

Mochizuki, Toshiki; Todoroki, Kenichiro; Inoue, Koichi; Min, Jun Zhe; Toyo’oka, Toshimasa

2014-01-01

Graphical abstract: -- Highlights: •Isotopic variants of chiral labeling reagents were newly synthesized. •Analysis of DL-amino acids was performed by UPLC–ESI–MS/MS. •Highly efficient enantioseparation and detection of DL-amino acids were performed. •Differential analysis of DL-amino acid was successfully performed in real samples. -- Abstract: L-Pyroglutamic acid succinimidyl ester (L-PGA-OSu) and its isotopic variant (L-PGA[d 5 ]-OSu) were newly synthesized and evaluated as the chiral labeling reagents for the enantioseparation of amino acids, in terms of separation efficiency by reversed-phase chromatography and detection sensitivity by ESI-MS/MS. The enantiomers of amino acids were easily labeled with the reagents at 60 °C within 10 min in an alkaline medium containing triethylamine. Although all the diastereomers derived from 18 proteolytic amino acids could not be satisfactorily separated, the pairs of 9 amino acids were completely separated by reversed-phase chromatography using the small particle (1.7 μm) ODS column (Rs = 1.95–8.05). The characteristic daughter ions, i.e., m/z 84.04 and m/z 89.04, were detected from all the derivatives by the collision induced dissociation of the protonated molecular ions. A highly sensitive detection at a low-fmol level (0.5–3.2 fmol) was also obtained from the selected reaction monitoring (SRM) chromatograms. An isotope labeling strategy using light and heavy L-PGA-OSu for the differential analysis of the DL-amino acids in different sample groups is also presented in this paper. The differential analysis of biological sample (i.e., human serum) and food product (i.e., yogurt) were tried to demonstrate the efficiency of the proposed method. The ratios of the DL-amino acids in human serum samples, spiked with the different concentrations of D-amino acids, were determined by the procedures using L-PGA-OSu and L-PGA[d 5 ]-OSu. The D/L ratios in the two sample groups at different concentrations of amino

Presence or absence of intestinal metaplasia but not its burden is associated with prevalent high-grade dysplasia and cancer in Barrett's esophagus.

Science.gov (United States)

Bansal, A; McGregor, D H; Anand, O; Singh, M; Rao, D; Cherian, R; Wani, S B; Rastogi, A; Singh, V; House, J; Jones, P G; Sharma, P

2014-01-01

Universal agreement on the inclusion of intestinal metaplasia to diagnose Barrett's esophagus (BE) is lacking. Our aim was to determine the association of intestinal metaplasia and its density with the prevalence of dysplasia/cancer in columnar lined esophagus (CLE). Patients with CLE but no intestinal metaplasia (CLE-no IM) were identified by querying the clinical pathology database using SNOMED codes for distal esophageal biopsies. CLE-IM patients were identified from a prospectively maintained database of BE patients. Subsequently, relative risks for prevalent dysplasia and cancer were calculated. Since patients with CLE-no IM are not usually enrolled in surveillance, only prevalent dysplasia/cancer on index endoscopy was analyzed. Goblet cell density and percent intestinal metaplasia were estimated. All biopsy slides were reviewed for dysplasia by two experienced gastrointestinal pathologists. Two hundred sixty-two CLE-IM and 260 CLE-no IM patients were included (age 64±12 vs. 60±11 years, P=0.001; whites 92% vs. 82%, P=0.001; males 99.7% vs. 99.3%, P=NS; CLE length 3.4±3.2 vears 1.4±0.4 cm, P=0.001 and hiatus hernia 64% vs. 56%, P=0.013). The odds of finding low-grade dysplasia and of high-grade dysplasia (HGD)/cancer were 12.5-fold (2.9-53.8, P=0.007) and 4.2-fold (95% CI 1.4-13, P=0.01) higher, respectively, in the CLE-IM group. Reanalysis after controlling for important variables of age, race, and length did not significantly alter the overall results. In CLE-IM group, when patients with high (>50/LPF) versus low goblet cell density (10% intestinal metaplasia were compared, the odds of HGD/cancer, OR 1.5 (0.5-4.9, P=0.5) and 1.97 (0.54-7.22), respectively, were not significantly higher. Demonstration of intestinal metaplasia continues to be an essential element in the definition of BE, but its quantification may not be useful for risk stratification of HGD/cancer in BE. © 2013 Wiley Periodicals, Inc. and the International Society for Diseases of

Christophe Couderc, Le théâtre tragique au Siècle d’or. Cristóbal de Virués, Lope de Vega, Calderón de la Barca - Christophe Couderc and Hélène Tropé, eds., La tragédie espagnole et son contexte européen. xvie-xviie siècles

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Luigi Giuliani

2015-01-01

Full Text Available Review of Christophe Couderc, Le théâtre tragique au Siècle d’or. Cristóbal de Virués, Lope de Vega, Calderón de la Barca, CNED, Paris, 2012, 170 pp. ISBN: 978213060871 and Christophe Couderc and Hélène Tropé, eds., La tragédie espagnole et son contexte européen. xvie-xviie siècles, Presses Sorbonne Nouvelle, Paris, 2013, 266 pp. ISBN: 9782878546118.

In Planta Processing and Glycosylation of a Nematode CLAVATA3/ENDOSPERM SURROUNDING REGION-Like Effector and Its Interaction with a Host CLAVATA2-Like Receptor to Promote Parasitism1[OPEN

Science.gov (United States)

Chen, Shiyan; Lang, Ping; Chronis, Demosthenis; Zhang, Sheng; De Jong, Walter S.; Mitchum, Melissa G.

2015-01-01

Like other biotrophic plant pathogens, plant-parasitic nematodes secrete effector proteins into host cells to facilitate infection. Effector proteins that mimic plant CLAVATA3/ENDOSPERM SURROUNDING REGION-related (CLE) proteins have been identified in several cyst nematodes, including the potato cyst nematode (PCN); however, the mechanistic details of this cross-kingdom mimicry are poorly understood. Plant CLEs are posttranslationally modified and proteolytically processed to function as bioactive ligands critical to various aspects of plant development. Using ectopic expression coupled with nanoliquid chromatography-tandem mass spectrometry analysis, we show that the in planta mature form of proGrCLE1, a multidomain CLE effector secreted by PCN during infection, is a 12-amino acid arabinosylated glycopeptide (named GrCLE1-1Hyp4,7g) with striking structural similarity to mature plant CLE peptides. This glycopeptide is more resistant to hydrolytic degradation and binds with higher affinity to a CLAVATA2-like receptor (StCLV2) from potato (Solanum tuberosum) than its nonglycosylated forms. We further show that StCLV2 is highly up-regulated at nematode infection sites and that transgenic potatoes with reduced StCLV2 expression are less susceptible to PCN infection, indicating that interference of the CLV2-mediated signaling pathway confers nematode resistance in crop plants. These results strongly suggest that phytonematodes have evolved to utilize host cellular posttranslational modification and processing machinery for the activation of CLE effectors following secretion into plant cells and highlight the significance of arabinosylation in regulating nematode CLE effector activity. Our finding also provides evidence that multidomain CLEs are modified and processed similarly to single-domain CLEs, adding new insight into CLE maturation in plants. PMID:25416475

Les ornements liturgiques au XIXe siècle : origine, fabrication et commercialisation, l’exemple du diocèse de Moulins (Allier

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Aurore Chatard

2012-04-01

Full Text Available Depuis le concile Vatican II, la volonté de l’Église catholique de tendre vers une plus grande simplicité pour réduire la distance, tant physique que psychologique, entre ses ministres et l’ensemble des fidèles a contribué à abandonner certains fastes de la liturgie. Aujourd’hui, l’étude des ornements liturgiques rend compte de leur place au cours des rites et de l’attention portée à leur réalisation. Le XIXe siècle est souvent considéré comme l’âge d’or de leur confection. Une recherche menée dans le diocèse de Moulins a permis de mettre au jour la richesse et la diversité des collections de cette époque, ainsi que le renouvellement de la portée symbolique et politique dont ils ont fait l’objet.Since the II Vatican Council, the wish of the Catholic Church for simplification in order to reduce the distance, both physically and psychologically, between their Ministers and all the believers, contributed to abandon some complex aspects of the liturgy. Nowadays, the liturgical ornaments studying, reports their role during the rites and the particular attention paid to their realization. The XIXth century is often considered as the golden age of their confection. A research led in the diocese of Moulins, allowed to reveal the wealth and the variety of this period’s collections, as well as the renewal of their symbolic and political mean.

Evidence for changing the critical level for ammonia

International Nuclear Information System (INIS)

Cape, J.N.; Eerden, L.J. van der; Sheppard, L.J.; Leith, I.D.; Sutton, M.A.

2009-01-01

The current critical level for ammonia (CLE NH3 ) in Europe is set at 8 μg NH 3 m -3 as an annual average concentration. Recent evidence has shown specific effects of ammonia (NH 3 ) on plant community composition (a true ecological effect) at much smaller concentrations. The methods used in setting a CLE NH3 are reviewed, and the available evidence collated, in proposing a new CLE NH3 for different types of vegetation. For lichens and bryophytes, we propose a new CLE NH3 of 1 μg NH 3 m -3 as a long-term (several year) average concentration; for higher plants, there is less evidence, but we propose a CLE NH3 of 3 ± 1 μg NH 3 m -3 for herbaceous species. There is insufficient evidence to provide a separate CLE NH3 for forest trees, but the value of 3 ± 1 μg NH 3 m -3 is likely to exceed the empirical critical load for N deposition for most forest ecosystems. - The long-term critical level for NH 3 has been revised down to 1 μg m -3 for the most sensitive plant species

Confocal Laser Endomicroscopy in the Study of Colonic Mucosa in IBD Patients: A Review

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Francesca Salvatori

2012-01-01

Full Text Available Confocal laser endomicroscopy (CLE is one of several novel methods that provide real-time, high-resolution imaging at a micronscale via endoscopes. CLE and related technologies are often termed “virtual biopsy” as they simulate the images seen in traditional histology. Recently, the use of CLE was reported in the study of colonic mucosa in patients with inflammatory bowel diseases and in particular in patients affected by ulcerative colitis. CLE has the potential to have an important role in management of IBD patients as it can be used to assess the grading of colitis and in detection of microscopic colitis in endoscopically silent segments. Moreover, CLE can be used in surveillance programs especially in high-risk patients. This report aims to evaluate the current data on the application of confocal endomicroscopy in clinical gastroenterology and particularly in the study of colonic mucosa in UC patients.

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition.

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Manalo, Rafael Vincent; Silvestre, Maries Ann; Barbosa, Aza Lea Anne; Medina, Paul Mark

2017-04-21

Virgin coconut oil (VCO) has been the subject of several studies which have aimed to alleviate Alzheimer's disease (AD) pathology, focusing on in vitro antioxidant and acetylcholinesterase (AChE) inhibitory activities. Here, we studied an underutilized and lesser-valued part of the coconut tree, specifically the leaves, using in vitro and in vivo approaches. Coconut leaf extract (CLE) was screened for antioxidant and AChE inhibitory properties in vitro and therapeutic effects in two strains of transgenic Caenorhabditis elegans expressing amyloid-β 1-42 (Aβ 1-42 ) in muscle cells. CLE demonstrated free radical scavenging activity with an EC 50 that is 79-fold less compared to ascorbic acid, and an AChE inhibitory activity that is 131-fold less compared to Rivastigmine. Surprisingly, in spite of its low antioxidant activity and AChE inhibition, CLE reduced Aβ deposits by 30.31% in CL2006 in a dose-independent manner, and reduced the percentage of paralyzed nematodes at the lowest concentration of CLE (159.38 μg/mL), compared to dH₂O/vehicle (control). Phytochemical analysis detected glycosides, anthocyanins, and hydrolyzable tannins in CLE, some of which are known to be anti-amyloidogenic. Taken together, these findings suggest that CLE metabolites alternatively decrease AB 1-42 aggregation and paralysis prevalence independently of free radical scavenging and AChE inhibition, and this warrants further investigation on the bioactive compounds of CLE.

Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00.

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Ravi D Barabote

Full Text Available Francisella tularensis subspecies holarctica FTNF002-00 strain was originally obtained from the first known clinical case of bacteremic F. tularensis pneumonia in Southern Europe isolated from an immunocompetent individual. The FTNF002-00 complete genome contains the RD(23 deletion and represents a type strain for a clonal population from the first epidemic tularemia outbreak in Spain between 1997-1998. Here, we present the complete sequence analysis of the FTNF002-00 genome. The complete genome sequence of FTNF002-00 revealed several large as well as small genomic differences with respect to two other published complete genome sequences of F. tularensis subsp. holarctica strains, LVS and OSU18. The FTNF002-00 genome shares >99.9% sequence similarity with LVS and OSU18, and is also approximately 5 MB smaller by comparison. The overall organization of the FTNF002-00 genome is remarkably identical to those of LVS and OSU18, except for a single 3.9 kb inversion in FTNF002-00. Twelve regions of difference ranging from 0.1-1.5 kb and forty-two small insertions and deletions were identified in a comparative analysis of FTNF002-00, LVS, and OSU18 genomes. Two small deletions appear to inactivate two genes in FTNF002-00 causing them to become pseudogenes; the intact genes encode a protein of unknown function and a drug:H(+ antiporter. In addition, we identified ninety-nine proteins in FTNF002-00 containing amino acid mutations compared to LVS and OSU18. Several non-conserved amino acid replacements were identified, one of which occurs in the virulence-associated intracellular growth locus subunit D protein. Many of these changes in FTNF002-00 are likely the consequence of direct selection that increases the fitness of this subsp. holarctica clone within its endemic population. Our complete genome sequence analyses lay the foundation for experimental testing of these possibilities.

Prevalence and predictors of columnar lined esophagus in gastroesophageal reflux disease (GERD) patients undergoing upper endoscopy.

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Balasubramanian, Gokulakrishnan; Singh, Mandeep; Gupta, Neil; Gaddam, Srinivas; Giacchino, Maria; Wani, Sachin B; Moloney, Brian; Higbee, April D; Rastogi, Amit; Bansal, Ajay; Sharma, Prateek

2012-11-01

Chronic gastroesophageal reflux disease (GERD) is a risk factor for Barrett's esophagus (BE), the most important surrogate marker for the development of esophageal adenocarcinoma (EAC). The need to document the presence of intestinal metaplasia in esophageal biopsies from a columnar lined esophagus (CLE) to diagnose BE is debated. The objective of this study was to prospectively evaluate the prevalence and risk factors of CLE in a large cohort of GERD patients undergoing upper endoscopy. Consecutive patients presenting to the endoscopy unit at a tertiary referral center for their index upper endoscopy for evaluation of GERD symptoms were enrolled in this prospective cohort study. Patients were asked to complete a validated GERD questionnaire that documents the onset of GERD symptoms (heartburn and acid regurgitation) and grades the frequency and severity of symptoms experienced over the past year. Demographic information, body mass index, and use of aspirin/nonsteroidal antiinflammatory drugs were recorded. Endoscopic details including length of CLE, presence and size of hiatal hernia were noted. Patients with CLE (cases) were compared with those without CLE (controls) using Fischer's exact test and t-test. All factors that were statistically significant (PGERD symptoms were prospectively enrolled. On index endoscopy, the prevalence of CLE was 23.3%, whereas of CLE with documented intestinal metaplasia was 14.1%. On univariate analysis, male gender, Caucasian race, heartburn duration of >5 years, presence and size of hiatal hernia were significantly associated with the presence of CLE compared with controls (P5 years (odds ratio (OR): 1.50, 95% confidence interval (CI): 1.07-2.09, P=0.01), Caucasian race (OR: 2.40, 95% CI: 1.42-4.03, P=0.001), and hiatal hernia (OR: 2.07, 95% CI: 1.50-2.87, PGERD patients are diagnosed with this lesion. Enrolling all these patients in surveillance programs would have significant ramifications on health-care resources.

In planta processing and glycosylation of a nematode CLAVATA3/ENDOSPERM SURROUNDING REGION-like effector and its interaction with a host CLAVATA2-like receptor to promote parasitism.

Science.gov (United States)

Chen, Shiyan; Lang, Ping; Chronis, Demosthenis; Zhang, Sheng; De Jong, Walter S; Mitchum, Melissa G; Wang, Xiaohong

2015-01-01

Like other biotrophic plant pathogens, plant-parasitic nematodes secrete effector proteins into host cells to facilitate infection. Effector proteins that mimic plant CLAVATA3/ENDOSPERM SURROUNDING REGION-related (CLE) proteins have been identified in several cyst nematodes, including the potato cyst nematode (PCN); however, the mechanistic details of this cross-kingdom mimicry are poorly understood. Plant CLEs are posttranslationally modified and proteolytically processed to function as bioactive ligands critical to various aspects of plant development. Using ectopic expression coupled with nanoliquid chromatography-tandem mass spectrometry analysis, we show that the in planta mature form of proGrCLE1, a multidomain CLE effector secreted by PCN during infection, is a 12-amino acid arabinosylated glycopeptide (named GrCLE1-1Hyp4,7g) with striking structural similarity to mature plant CLE peptides. This glycopeptide is more resistant to hydrolytic degradation and binds with higher affinity to a CLAVATA2-like receptor (StCLV2) from potato (Solanum tuberosum) than its nonglycosylated forms. We further show that StCLV2 is highly up-regulated at nematode infection sites and that transgenic potatoes with reduced StCLV2 expression are less susceptible to PCN infection, indicating that interference of the CLV2-mediated signaling pathway confers nematode resistance in crop plants. These results strongly suggest that phytonematodes have evolved to utilize host cellular posttranslational modification and processing machinery for the activation of CLE effectors following secretion into plant cells and highlight the significance of arabinosylation in regulating nematode CLE effector activity. Our finding also provides evidence that multidomain CLEs are modified and processed similarly to single-domain CLEs, adding new insight into CLE maturation in plants. © 2015 American Society of Plant Biologists. All Rights Reserved.

Avaliação de citrandarins e outros híbridos de trifoliata como porta-enxertos para citros em São Paulo Performance of citrandarins and others trifoliate hybrids rootstocks in Sao Paulo, Brazil

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Silvia Blumer

2005-08-01

Full Text Available Laranjeiras Valência enxertadas em citrandarins e outros híbridos de trifoliata foram plantadas em 1988, em Itirapina (SP, num Latossolo Vermelho-Amarelo textura arenosa e conduzidas sem irrigação. O citrandarin Sunki x English (1.628, sem diferir estatisticamente de Cleópatra x Rubidoux (1.660, Cleópatra x English (710, Cleópatra x Swingle (715 e do trangpur Cravo x Carrizo (717, induziu a maior produção de frutos nas cinco primeiras colheitas do experimento (1991-1995, sendo que os três primeiros foram os mais produtivos nas três últimas colheitas. Os citranges Troyer e Carrizo foram significativamente inferiores aos citrandarins Sunki x English (1.628, Cleópatra x Rubidoux (1.660 e Cleópatra x English (710 em todos os anos, exceto 1994. Nenhuma das plantas apresentou sintomas de suscetibilidade à tristeza ou ao declínio. Os seedlings dos porta-enxertos diferiram quanto à área lesionada pela inoculação com Phytophthora parasitica. Os citrandarins Cleópatra x Swingle (1.587, Cleópatra x Trifoliata (1.574, Cleópatra x Rubidoux (1.600, Clementina x Trifoliata (1.615 e o limão Cravo x citrange Carrizo (717 foram significativamente mais resistentes que Cleópatra x Christian (712, Sunki x English (1.628, Cleópatra x Swingle (715 e Cleópatra x English (710.Valencia sweet orange trees budded onto citrandarins and others trifoliate hybrids rootstocks from the USDA Horticultural Research Laboratory, Fort Pierce, Florida, were planted in 1988 on a sandy textured Oxisol in São Paulo State, Brazil, and managed without irrigation. Tristeza and blight diseases are endemic in this area. Trees of Sunki x English (1.628, Cleopatra x Rubidoux (1.660, Cleopatra x English (710, Cleopatra x Swingle (715 and Rangpur lime x Carrizo citrange (717, produced the highest cumulative yields in the first five crops (1991-1995. The first three rootstocks induced the highest crops in the last three years. Carrizo and Troyer citranges had the lowest

Confocal laser endomicroscopy for diagnosis of Barrett´s esophagus

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Helmut eNeumann

2012-05-01

Full Text Available Barrett´s esophagus (BE is established as a premalignant condition in the distal esophagus. Current surveillance guidelines recommend random biopsies every 1-2 cm at intervals of 3-5 years. Advanced endoscopic imaging of BE underwent several technical revolutions within the last decade including broad-field (red-flag techniques (e.g. chromoendoscopy and small-field techniques with confocal laser endomicroscopy (CLE at the forefront. In this review we will focus on advanced endoscopic imaging using CLE for the diagnosis and characterization of BE and associated neoplasia. In addition, we will critically discuss the technique of CLE and provide some tricks and hints for the daily routine practice of CLE for diagnosis of BE.

N-hydroxysuccinimide-hippuran ester: application for radiolabeling of macromolecules

International Nuclear Information System (INIS)

Chervu, L.R.; Chun, S.B.; Bhargava, K.K.

1987-01-01

A method for synthesis of N-hydroxysuccinimide ester of radioactive orthoiodohippurric acid (OIH-OSU) is developed in order to label macromolecules including antibodies. The OIH-OSU is prepared in 87% yield by reacting molar equivalents of o-iodohippuric acid, N:N-di-succinimidyl carbonate and pyridine in DMF overnight. The active labeled ester is obtained using high specific activity OIH in a similar synthetic protocol. Conjugation of OIH-OSU to human serum albumin is effected by incubating the reactants for half an hour at room temperature followed by purification of the labeled protein on a Sephadex G-100 column with activity yield of 44.3%. Organ distribution for the labeled albumin preparation and the commercial iodinated human serum albumin (RISA) in mice and rats is similar. As expected urinary excretion of radioactivity for the labeled preparation is greater than that of RISA reflecting the rapid urinary clearance of the OIH moiety released into the bloodstream. Hippuran labeling method offers a mild and rapid protocol for radioiodine labeling of proteins and antibodies for application in diagnostic nuclear medicine procedures

Confocal Endomicroscopy of Colorectal Polyps

Directory of Open Access Journals (Sweden)

Vivian M. Ussui

2012-01-01

Full Text Available Confocal laser endomicroscopy (CLE is one of several novel methods that provide real-time, high-resolution imaging at a micron scale via endoscopes. CLE has the potential to be a disruptive technology in that it can change the current algorithms that depend on biopsy to perform surveillance of high-risk conditions. Furthermore, it allows on-table decision making that has the potential to guide therapy in real time and reduce the need for repeated procedures. CLE and related technologies are often termed “virtual biopsy” as they simulate the images seen in traditional histology. However, the imaging of living tissue allows more than just pragmatic convenience; it also allows imaging of living tissue such as active capillary circulation, cellular death, and vascular and endothelial translocation, thus extending beyond what is capable in traditional biopsy. Immediate potential applications of CLE are to guide biopsy sampling in Barrett's esophagus and inflammatory bowel disease surveillance, evaluation of colorectal polyps, and intraductal imaging of the pancreas and bile duct. Data on these applications is rapidly emerging, and more is needed to clearly demonstrate the optimal applications of CLE. In this paper, we will focus on the role of CLE as applied to colorectal polyps detected during colonoscopy.

L’enfant pauvre et la naissance de la photographie sociale aux États-Unis au XIXe siècle

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Anne LESME

2010-03-01

Full Text Available À la fin du XIXe siècle, le journaliste et photographe Jacob Riis révèle les conditions de vie déplorables des familles d’immigrants à New York. C’est le début de la photographie sociale aux États-Unis où la représentation de l’enfant pauvre tiendra une place majeure. Ses photographies, projetées au cours de conférences faites par l’auteur et reproduites dans des publications, contribueront à un changement de mentalité. Si le regard de ce photographe reste celui d’un membre de la classe moyenne sur les enfants du Lower East Side, ses images apportent une nouvelle vision de la pauvreté, en phase avec un enfant désormais perçu comme innocent par la société. Par ailleurs, cet usage particulier du rôle probant de la photographie en soutien du texte inaugure un nouveau mode de communication dont les réformateurs useront afin d’émouvoir et de faire réagir le public des classes moyennes et aisées.At the end of the 19th century, Jacob Riis, journalist and photographer, brought to light the appalling conditions of the slums in New York; it was the beginning of the social documentary photography in the United States. The representation of destitute children was to become central in this genre. His photographs, used during stereopticon slides projections and published in books and articles, contributed to a change of mentality. However influenced by a middle-class vision of the Lower East Side’s children, Jacob Riis’s photographs contributed to bring a new perception of poverty in line with a child who was from that time perceived as innocent by a large part of society. This particular use of photography as a convincing and reliable medium added to the text initiated a new means of communication used by the reformers to move and provoke reactions from a middle and upper-class public.

Achats et ventes de terres par les indiens de Cuenca au XVIIe siècle: éléments de conjoncture économique et de stratification sociale

Directory of Open Access Journals (Sweden)

1992-01-01

Full Text Available Dans cet article, l'auteur étudie les contrats d'achat-vente de terres réalisés par les indiens du corregimiento de Cuenca (Equateur au XVIIº siècle. Après avoir présenté les problèmes méthodologiques, il analyse les différentes informations que contient la source concernant la nature des transactions, 1''identité' des intervenants indiens et la perspective des contrats une chronologie des phénomènes est proposée, montrant pour ce siècle les fluctuations des achats et des ventes, du lien ville-campagne. À travers cette étude, il s'agit d'une contribution au problème de la participation indienne au marché colonial - dans le cas présent, foncier et immobilier - en même temps que d'une approche de la mobilité et de la différenciation sociale interne au monde indigène pendant la Colonie. COMPRAS Y VENTAS DE TIERRAS POR LOS INDIOS DE CUENCA EN EL SIGLO XVII: ELEMENTOS DE COYUNTURA ECONÓMICA Y DE ESTRATIFICACIÓN SOCIAL. En este artículo, el autor estudia los contratos de compra-venta de tierras realizados por los indios del corregimiento de Cuenca (Ecuador en el siglo XVII. Después de haber presentado los aspectos metodológicos, analiza las distintas informaciones que contienen las fuentes en cuanto a la naturaleza de las transacciones, la 'identidad' de los participantes indígenas y la perspectiva de los contratos se propone una cronología de los fenómenos, diseñando para este siglo las fluctuaciones de las compras-ventas y del nexo ciudad-campo. A través de este estudio, se trata de dar una contribución al problema de la participación indígena al mercado colonial -en este caso, territorial e inmobiliario- al mismo tiempo que de un acercamiento a la movilidad y a la diferenciación social interna del mundo indígena colonial. LAND PROCUREMENT AND SALE BY THE CUENCA INDIANS OF THE 17TH CENTURY: CONSTITUENTS FOR FINANCIAL CONJUNCTION AND SOCIAL STATUS. Through the present article, the author analyses the land

Sulfonated polystyrene magnetic nanobeads coupled with immunochromatographic strip for clenbuterol determination in pork muscle.

Science.gov (United States)

Wu, Kesheng; Guo, Liang; Xu, Wei; Xu, Hengyi; Aguilar, Zoraida P; Xu, Guomao; Lai, Weihua; Xiong, Yonghua; Wan, Yiqun

2014-11-01

A magnetic solid-phase extraction method (MSPE) was developed to pre-concentrate and cleanup clenbuterol (CLE) from pork muscle. Novel sulfonated polystyrene magnetic nanobeads (spMNBs) were synthesized via a one-pot emulsion copolymerization method by using divinylbenzene, styrene, and sodium styrene sulfonate in the presence of oleic acid-modified and 10-undecylenic acid-modified magnetic ferrofluid. The resulting spMNBs exhibited high adsorption efficiency for CLE and for 10 other common beta-adrenergic agonists, namely, brombuterol, ractopamine, tulobuterol, bambuterol, cimbuterol, mabuterol, clorprenaline, penbutolol, salbutamol, and cimaterol. The adsorption behavior of the spMNBs for CLE was described by the Langmuir equation with a maximum adsorption capacity of 0.41 mg/g. Under the optimized parameters, the extraction of CLE from 0.5 g of pork muscle required 25mg of the spMNBs at a shortened adsorption time (0.5 min). The proposed MSPE was coupled with colloidal gold nanoparticle-based immunochromatographic assay (MSPE-AuNPIA) for the quantitative detection of CLE residue in pork muscle. The limit of detection and limit of quantification for the pork muscle were 0.10 and 0.24 ng/g, respectively. The intra-day and inter-day assay recoveries at three CLE spiked concentrations ranged from 92.5% to 98.1%, with relative standard deviations ranging from 3.2% to 13.0%. The results of MSPE-AuNPIA were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The CLE values obtained with MSPE-AuNPIA agreed with those obtained with LC-MS/MS. Copyright © 2014 Elsevier B.V. All rights reserved.

Fast stochastic simulation of biochemical reaction systems by alternative formulations of the chemical Langevin equation

KAUST Repository

Mélykúti, Bence

2010-01-01

The Chemical Langevin Equation (CLE), which is a stochastic differential equation driven by a multidimensional Wiener process, acts as a bridge between the discrete stochastic simulation algorithm and the deterministic reaction rate equation when simulating (bio)chemical kinetics. The CLE model is valid in the regime where molecular populations are abundant enough to assume their concentrations change continuously, but stochastic fluctuations still play a major role. The contribution of this work is that we observe and explore that the CLE is not a single equation, but a parametric family of equations, all of which give the same finite-dimensional distribution of the variables. On the theoretical side, we prove that as many Wiener processes are sufficient to formulate the CLE as there are independent variables in the equation, which is just the rank of the stoichiometric matrix. On the practical side, we show that in the case where there are m1 pairs of reversible reactions and m2 irreversible reactions there is another, simple formulation of the CLE with only m1 + m2 Wiener processes, whereas the standard approach uses 2 m1 + m2. We demonstrate that there are considerable computational savings when using this latter formulation. Such transformations of the CLE do not cause a loss of accuracy and are therefore distinct from model reduction techniques. We illustrate our findings by considering alternative formulations of the CLE for a human ether a-go-go related gene ion channel model and the Goldbeter-Koshland switch. © 2010 American Institute of Physics.

Voyageuses occidentales et impérialisme : l’Orient à la croisée des représentations (XIXe siècle

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Isabelle Ernot

2011-11-01

Full Text Available Cet article s’appuie sur une dizaine de récits de voyages, effectués par des Françaises dans les régions arabo-musulmanes durant la seconde moitié du XIXe siècle. Ils constituent un matériau permettant d’articuler étude sur le genre et l’impérialisme. Le propos concerne particulièrement le rôle des Occidentales dans la construction d’un discours qui accompagne la colonisation et participe de la définition des hiérarchies sociales et/ou raciales. L’analyse comporte deux versants : le premier s’intéresse aux éléments mobilisés dans la production d’une représentation de la femme arabo-musulmane, figure de l’assujettissement et contre-modèle de l’Occidentale ; le second fait retour sur les locutrices elles-mêmes et questionne l’origine de leurs représentations.This article explores how gender and imperialism are articulated in the writings of a number of French women travelers to Eastern and Arab countries in the second half of the 19th century. It argues for the role of these Western women travelers in the construction of a discourse that accompanied the process of colonialism and contributed to the defining of social and/or racial hierarchies. The article begins with an examination of the rhetoric used to produce a representation of the oppressed Arab-Muslim woman, in opposition to that of the Western woman. It then examines the travel writers themselves in an effort to discern the origins of the representations they develop.

L’émoi des demoiselles en voyage. Du voyage dans quelques journaux intimes de jeunes filles du XIXe siècle

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Martine Sonnet

2012-06-01

Full Text Available Le corpus de journaux intimes de jeunes filles du XIXe siècle constitué par Philippe Lejeune (Le moi des demoiselles : enquête sur le journal de jeune fille, 1993 se prête à une lecture  mettant en évidence la rupture provoquée par le voyage dans le terne ordinaire des jours de jeunes bourgeoises ou de jeunes aristocrates. Une trentaine de journaux évoquant des voyages dévoilent l’ambivalence des émotions que suscitent des déplacements, toujours accomplis sous bonne escorte, remplissant le plus souvent des fonctions combinées : touristiques, familiales, thérapeutiques, éducatives etc.. Joie et anxiété des préparatifs et du départ, craintes et désirs de rencontres dans la promiscuité des chemins de fer, excitation au passage des frontières et soulagement de rentrer chez soi saine et sauve : autant de sentiments confiés à leurs journaux par les jeunes diaristes voyageuses.Travelling Demoiselles’ Emotions : travel in girls’ diaries in the nineteenth centuryThe collection of nineteenth century’s girls’ private diaries studied by Philippe Lejeune (Le moi des demoiselles : enquête sur le journal de jeune fille, 1993 reveals the way travel interrupted the often dull routine of young bourgeois and aristocratic girls. About thirty diaries display the mixed feelings that travel generated for these girls who left home, most often with family members, to discover new places, attend family events, restore health, or acquire education, etc. This selection of texts highlights such topics as the pleasure and anxiety of leaving home, the fear and desire of railway travels’ unexpected encounters, the exhilaration in crossing borde.

Probe station for testing of ALICE silicon drift detectors

CERN Document Server

Humanic, T J; Piemonte, C; Rashevsky, A; Sugarbaker, E R; Vacchi, A

2003-01-01

Large area, 7.25 cm multiplied by 8.76 cm silicon drift detectors have been developed and are in production for the ALICE experiment at LHC. An active area of the detector of more than 50 cm**2 imposes high demands on the quality of processing and raw material. Automated testing procedures have been developed to test detectors before mounting them on the ladders. Probe stations for ALICE SDD testing were designed and built at INFN, Trieste and Ohio State University (OSU). Testing procedures, detector selection criteria and some details of the OSU probe station design are discussed.

Diversité des théories libérales en Grèce au XIXe siècle

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Roxane D. Argyropoulos

2005-01-01

Full Text Available Étudier l'émergence du mouvement libéral en Grèce au XIXe siècle implique une série de difficultés d'interprétation. C'est appréhender un univers qui a été légué par la Révolution française et nous conduit à l'acquisition de principes indispensables au fonctionnement d'une société démocratique moderne. Υ travers des types de discours différents, nous essayons de suivre les traces de cette mise en œuvre du principe de la liberté de 1830 jusqu'à la veille du premier conflit mondial. On assiste après 1830, à une période de transition mais également de mise en œuvre des idées novatrices des Lumières. Les libéraux grecs ont pris fait et cause pour des combats concernant le respect de la vie humaine, la réciprocité des droits et des devoirs et sont dominés par la préoccupation de la liberté d'expression et de création, l'abolition de la peine de mort, l'idéal républicain, l'instruction publique, le défi du progrès. Depuis les années 1830 jusqu'en 1870, se réclamer du libéralisme, c'est s'inscrire dans les forces progressistes. Mais, la dernière phase de son édification fut liée à la montée du socialisme et du marxisme, qu'il allait remettre en question, et dans les années qui ont suivi la défaite de 1897, le libéralisme est confronté à des théories comme la pensée polyvalente de Nietzsche. Dans les différentes phases de l'évolution de la pensée libérale en Grèce, on observe des variations qui pour la plupart sont des étapes du processus vers la démocratie.

Complex Langevin Simulations of QCD at Finite Density - Progress Report

Science.gov (United States)

Sinclair, D. K.; Kogut, J. B.

2018-03-01

We simulate lattice QCD at finite quark-number chemical potential to study nuclear matter, using the complex Langevin equation (CLE). The CLE is used because the fermion determinant is complex so that standard methods relying on importance sampling fail. Adaptive methods and gauge-cooling are used to prevent runaway solutions. Even then, the CLE is not guaranteed to give correct results. We are therefore performing extensive testing to determine under what, if any, conditions we can achieve reliable results. Our earlier simulations at β = 6/g2 = 5.6, m = 0.025 on a 124 lattice reproduced the expected phase structure but failed in the details. Our current simulations at β = 5.7 on a 164 lattice fail in similar ways while showing some improvement. We are therefore moving to even weaker couplings to see if the CLE might produce the correct results in the continuum (weak-coupling) limit, or, if it still fails, whether it might reproduce the results of the phase-quenched theory. We also discuss action (and other dynamics) modifications which might improve the performance of the CLE.

Disease: H01595 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available a single entity without associated systemic autoimmunity (LE-specific skin disease). Despite ongoing rese...arch into the cause of CLE, it remains unclear how CLE relates to SLE pathogenesis.

La science comme pratique d’intégration dans la société des princes. Les Grimaldi de Monaco et la curiosité savante (xviie–xviiie siècle

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Thomas Fouilleron

2011-09-01

Full Text Available Jusque-là seigneur de Monaco, Honoré II (1597-1662 prend, en 1612, le titre de prince. En 1641, il se place sous la protection du roi de France qui confirme, par le traité de Péronne, sa souveraineté. Parallèlement à son effort d’affirmation politique, il s’attache à intégrer la société européenne des princes en adoptant les pratiques culturelles de la distinction monarchique.Souverains à Monaco et grands aristocrates en France, les Grimaldi constituent, au xviie siècle, des cabinets de curiosités. Miroirs de souveraineté, substituts de regalia ou de mirabilia, ces objets rares et précieux publient l’éminence de la dynastie aux yeux des visiteurs de leurs palais, en particulier des voyageurs savants en route vers l’Italie. La qualité de ces derniers en fait des hôtes choyés par les princes. Même si certains, comme le mathématicien Bernouilli ou l’astronome Cassini, n’ont qu’une vision rapide et lointaine de la Principauté, d’autres, comme le géologue Saussure, le naturaliste Millin ou le médecin botaniste Fodéré, usent de leur regard de spécialistes pour décrire les spécificités du petit État dans leur discipline. Certains s’arrêtent, comme le père jésuite Laval, en 1719, pour faire des expérimentations devant le prince Antoine Ier (1661-1731, qui, dans sa bibliothèque, conserve des outils de géométrie. Amateur d’art et esprit éclairé, Jacques Ier (1689-1751 achète, quant à lui, des instruments du cabinet de Bonnier de La Mosson. La provenance prestigieuse de ces objets distingue et sanctionne sa curiosité. À la fin du xviiie siècle, la science devient « utile » et objet de gouvernement. Honoré III (1720-1795 commande des mémoires sur la culture du mûrier. Il fait venir de façon précoce des chevaux anglais pour améliorer la race normande et recourt à l’expertise d’un agronome d’outre-Manche pour mettre en valeur ses terres. À Monaco, il fait évaluer par

Expert-led didactic versus self-directed audiovisual training of confocal laser endomicroscopy in evaluation of mucosal barrier defects.

Science.gov (United States)

Huynh, Roy; Ip, Matthew; Chang, Jeff; Haifer, Craig; Leong, Rupert W

2018-01-01

 Confocal laser endomicroscopy (CLE) allows mucosal barrier defects along the intestinal epithelium to be visualized in vivo during endoscopy. Training in CLE interpretation can be achieved didactically or through self-directed learning. This study aimed to compare the effectiveness of expert-led didactic with self-directed audiovisual teaching for training inexperienced analysts on how to recognize mucosal barrier defects on endoscope-based CLE (eCLE).  This randomized controlled study involved trainee analysts who were taught how to recognize mucosal barrier defects on eCLE either didactically or through an audiovisual clip. After being trained, they evaluated 6 sets of 30 images. Image evaluation required the trainees to determine whether specific features of barrier dysfunction were present or not. Trainees in the didactic group engaged in peer discussion and received feedback after each set while this did not happen in the self-directed group. Accuracy, sensitivity, and specificity of both groups were compared. Trainees in the didactic group achieved a higher overall accuracy (87.5 % vs 85.0 %, P  = 0.002) and sensitivity (84.5 % vs 80.4 %, P  = 0.002) compared to trainees in the self-directed group. Interobserver agreement was higher in the didactic group (k = 0.686, 95 % CI 0.680 - 0.691, P  barrier defects on eCLE.

Comparison of closely related, uncultivated Coxiella tick endosymbiont population genomes reveals clues about the mechanisms of symbiosis.

Science.gov (United States)

Tsementzi, Despina; Castro Gordillo, Juan; Mahagna, Mustafa; Gottlieb, Yuval; Konstantinidis, Konstantinos T

2018-05-01

Understanding the symbiotic interaction between Coxiella-like endosymbionts (CLE) and their tick hosts is challenging due to lack of isolates and difficulties in tick functional assays. Here we sequenced the metagenome of a CLE population from wild Rhipicephalus sanguineus ticks (CRs) and compared it to the previously published genome of its close relative, CLE of R. turanicus (CRt). The tick hosts are closely related sympatric species, and their two endosymbiont genomes are highly similar with only minor differences in gene content. Both genomes encode numerous pseudogenes, consistent with an ongoing genome reduction process. In silico flux balance metabolic analysis (FBA) revealed the excess production of L-proline for both genomes, indicating a possible proline transport from Coxiella to the tick. Additionally, both CR genomes encode multiple copies of the proline/betaine transporter, proP gene. Modelling additional Coxiellaceae members including other tick CLE, did not identify proline as an excreted metabolite. Although both CRs and CRt genomes encode intact B vitamin synthesis pathway genes, which are presumed to underlay the mechanism of CLE-tick symbiosis, the FBA analysis indicated no changes for their products. Therefore, this study provides new testable hypotheses for the symbiosis mechanism and a better understanding of CLE genome evolution and diversity. © 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

The Honey-lips et The Guarani : les romans de José de Alencar en langue anglaise à la fin du XIXe siècle

Directory of Open Access Journals (Sweden)

Valéria Cristina Bezerra

2016-10-01

Full Text Available Dans les dernières décennies du XIXe siècle, deux romans de José de Alencar ont été traduits et obtenu circulation dans des pays de langue anglaise. Iraçéma : the honey-lips, version de Isabel Burton, est apparue en 1886 à Londres, em suscitant la réception critique dans des journaux du Royaume-Uni. The Guarany, traduit par James William Hawes, est sorti de façon découpée en 1893 dans le jornal Overland Monthly and Out West Magazine, de San Francisco, aux États-Unis, pays où Alencar a aussi été mentionné par la presse locale. Ce travail se propose d’analyser la réception de ces ouvrages et de José de Alencar dans le Royaume-Uni et les États- Unis. Il a également pour but de vérifier le rôle des traducteurs, éditeurs, critiques et de la presse dans la configuration de l’évaluation de cet écrivain et de ses oeuvres dans ces pays, en considérant, toujours que possible, le rapport de ces passeurs avec la culture brésilienne. La réception critique de Alencar dans ces pays révèle sa bonne évaluation aussi bien que la traduction de ses romans semble avoir répondu à l’intérêt du public étranger à s’illustrer.

La gastronomie dans les guides de voyage : de la richesse industrielle au patrimoine culturel, France XIXe-début XXe siècle

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Julia Csergo

2011-06-01

Full Text Available Les guides de voyage constituent une source majeure pour une histoire de l’alimentation. Ils nous éclairent sur les temps et les lieux des productions et des consommations alimentaires, sur la construction des images des territoires gourmands et des stéréotypes culinaires. Au-delà, ils constituent, surtout à partir du XIXe siècle qui voit la naissance concomitante de la notion de « gastronomie » (pratique sociale qui s’organise autour de savoir et de savoir-faire, de rites, de gestes et de discours et de celle de « patrimoine » (monument historique, un des principaux médias par lequel appréhender le processus de culturalisation et de patrimonialisation de la gastronomie qui devient, pour le touriste, une forme de consommation culturelle, au même titre que celle des sites et monuments.Travel guides constitute a major source for an history of food. They shed light on times and places of the food productions and consumptions, on the building of the « gourmands » territories and of culinary stereotypes. Moreover, they constitute, especially since the 19h century, in which emerge the notions of “gastronomy” (a social practice organized around knowledge and know-how, rituals, gestures and discourses and “patrimony” (historic building, one of the main mass media relating the process of gastronomy becoming a cultural legacy becoming, for the tourist, a way of cultural consumption, just like sites and monuments.

L’Homme, un itinéraire vietnamien. Humanisme et sujet humain au xxe siècle Man, a Vietnamese Itinerary. Humanism and the Human Subject in the 20th Century

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Daniel Hémery

2009-10-01

Full Text Available Cette étude interroge la confrontation qui s’est instaurée au Vietnam depuis le milieu du xixe siècle – et sans doute bien avant – entre la conception de l’homme-individu importée par les Occidentaux en Asie orientale et les philosophies du sujet qui s’y étaient développées depuis l’antiquité chinoise. Cette confrontation a-t-elle abouti dans la culture vietnamienne à une réévaluation socialement acceptée du statut du sujet et sur une nouvelle figure de l’humanisme ? Quel bilan provisoire dresser ?This paper examines the mid 19th century encounter in Vietnamese culture of the concept of the individual imported by Westerners to Far East Asia with the philosophical tradition of the human subject that has developed in China since the classic period. Did this conflictual encounter result in a new, socially acceptable evaluation of the human statute and in a renewed Vietnamese humanism? This article concludes with a provisional assessment of a cultural confrontation.

Hydrogeology and geochemistry of low-permeability oil-shales - Case study from HaShfela sub-basin, Israel

Science.gov (United States)

Burg, Avihu; Gersman, Ronen

2016-09-01

Low permeability rocks are of great importance given their potential role in protecting underlying aquifers from surface and buried contaminants. Nevertheless, only limited data for these rocks is available. New appraisal wells drilled into the oil shale unit (OSU) of the Mt. Scopus Group in the HaShfela sub-basin, Central Israel, provided a one-time opportunity for detailed study of the hydrogeology and geochemistry of this very low permeability unit. Methods used include: slug tests, electrical logs, televiewer imaging, porosity and permeability measurements on core samples, chemical analyses of the rock column and groundwater analyses. Slug tests yielded primary indication to the low permeability of the OSU despite its high porosity (30-40%). Hydraulic conductivities as low as 10-10-10-12 m/s were calculated, using both the Hvorslev and Cooper-Bredehoeft-Papadopulos decoding methods. These low conductivities were confirmed by direct measurements of permeability in cores, and from calculations based on the Kozeny-Carman approach. Storativity was found to be 1 · 10-6 and specific storage - 3.8 · 10-9 m-1. Nevertheless, the very limited water flow in the OSU is argued to be driven gravitationally. The extremely slow recovery rates as well as the independent recovery of two adjacent wells, despite their initial large head difference of 214 m, indicate that the natural fractures are tight and are impermeable due to the confining stress at depth. Laboratory measured permeability is similar or even higher than the field-measured values, thereby confirming that fractures and bedding planes do not form continuous flow paths. The vertical permeability along the OSU is highly variable, implying hydraulic stratification and extremely low vertical hydraulic conductivity. The high salinity of the groundwater (6300-8000 mgCl/L) within the OSU and its chemical and isotopic compositions are explained by the limited water flow, suggesting long residence time of the water

Creating and evaluating a new clicker methodology

Science.gov (United States)

Li, Pengfei

"Clickers", an in-class polling system, has been used by many instructors to add active learning and formative assessment to previously passive traditional lectures. While considerable research has been conducted on clicker increasing student interaction in class, less research has been reported on the effectiveness of using clicker to help students understand concepts. This thesis reported a systemic project by the OSU Physics Education group to develop and test a new clicker methodology. Clickers question sequences based on a constructivist model of learning were used to improve classroom dynamics and student learning. They also helped students and lecturers understand in real time whether a concept had been assimilated or more effort was required. Chapter 1 provided an introduction to the clicker project. Chapter 2 summarized widely-accepted teaching principles that have arisen from a long history of research and practice in psychology, cognitive science and physics education. The OSU clicker methodology described in this thesis originated partly from our years of teaching experience, but mostly was based on these teaching principles. Chapter 3 provided an overview of the history of clicker technology and different types of clickers. Also, OSU's use of clickers was summarized together with a list of common problems and corresponding solutions. These technical details may be useful for those who want to use clickers. Chapter 4 discussed examples of the type and use of question sequences based on the new clicker methodology. In several years of research, we developed a base of clicker materials for calculus-based introductory physics courses at OSU. As discussed in chapter 5, a year-long controlled quantitative study was conducted to determine whether using clickers helps students learn, how using clickers helps students learn and whether students perceive that clicker has a positive effect on their own learning process. The strategy for this test was based on

Ultraviolet light protection by a sunscreen prevents interferon-driven skin inflammation in cutaneous lupus erythematosus.

Science.gov (United States)

Zahn, Sabine; Graef, Medina; Patsinakidis, Nikolaos; Landmann, Aysche; Surber, Christian; Wenzel, Joerg; Kuhn, Annegret

2014-07-01

Irradiation with ultraviolet (UV) light is an important exacerbating factor in cutaneous lupus erythematosus (CLE) and induces various effects in the skin of patients with the disease, such as cell death and inflammation. Recently, we demonstrated the ability of a broad-spectrum sunscreen to prevent UV-induced damage both in patients with CLE and healthy controls (HCs). The aim of this study was to evaluate whether the UV-dependent activation of interferon (IFN)-driven inflammation in CLE can also be prevented by application of the sunscreen. In 20 patients with different subtypes of CLE and 10 HCs, defined areas on the upper back were treated with a broad-spectrum liposomal sunscreen 20 min prior to a combined standardized UVA/UVB irradiation. Immunohistological analyses using antibodies directed against MxA, CD11c, CD123 and CD68 were performed from skin biopsies taken from areas before UV irradiation as well as from sunscreen-treated and sunscreen-untreated areas 24 and 72 h after UV irradiation. The expression of MxA was completely prevented by the sunscreen applied prior to UV irradiation in CLE patients and HCs. Additionally, sunscreen protection significantly diminished the number of the CD11c- and CD123-positive dendritic cells, which are suggested to be a major source of type I/III IFNs, in UV-irradiated skin of patients with CLE. Moreover, the application of the sunscreen prevented the increase in CD68-positive macrophages in both groups 72 h after UV irradiation. The data of this study demonstrate that UV protection reduces lesional tissue damage and inhibits the typical IFN-driven inflammatory response in CLE. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The impact of the EUSCLE Core Set Questionnaire for the assessment of cutaneous lupus erythematosus.

Science.gov (United States)

Kuhn, A; Patsinakidis, N; Bonsmann, G

2010-08-01

Epidemiological data and standard European guidelines for the diagnosis and treatment of cutaneous lupus erythematosus (CLE) are lacking in the current literature. In order to provide a standardized tool for an extensive consistent data collection, a study group of the European Society of Cutaneous Lupus Erythematosus (EUSCLE) recently developed a Core Set Questionnaire for the assessment of patients with different subtypes of CLE. The EUSCLE Core Set Questionnaire includes six sections on patient data, diagnosis, skin involvement, activity and damage of disease, laboratory analysis, and treatment. An instrument like the EUSCLE Core Set Questionnaire is essential to gain a broad and comparable data collection of patients with CLE from different European centres and to achieve consensus concerning clinical standards for the disease. The data will also be important for further characterization of the different CLE subtypes and the evaluation of therapeutic strategies; moreover, the EUSCLE Core Set Questionnaire might also be useful for the comparison of data in clinical trials. In this review, the impact of the EUSCLE Core Set Questionnaire is discussed in detail with regard to clinical and serological features as well as therapeutic modalities in CLE.

Le règlement de compte littéraire au siècle d’or : quand la fiction doit détruire la réalité

Directory of Open Access Journals (Sweden)

Florence Dumora

2009-10-01

Full Text Available Cet article propose l’étude des rapports entre un auteur original et un auteur apocryphe, tels qu’ils s’expriment au sein de la fiction elle-même. La littérature espagnole du Siècle d’Or offre deux cas aussi remarquables que connus de cette situation littéraire – Don Quijote de la Mancha (1605 et 1615 et Guzmán de Alfarache (1599 et 1604 – où la fiction devient le double lieu de l’invention narrative et de la critique de l’apocryphe, médiatisée et permise par les éléments propres à la technique narrative mais tirés aussi de la réalité éditoriale que constitue l’imposture : les deux œuvres se composent de deux parties, et par là même fonctionnent de façon spéculaire non seulement par rapport à elles-mêmes mais aussi par rapport aux textes apocryphes qui furent élaborés et publiés entre les deux parties de l’original. Cette imbrication donne au fait littéraire une dimension métalittéraire et scelle le statut de l’auteur authentique par rapport à l’apocryphe, qui n’en demeure pas moins auteur pour la postérité.

Tradition et modernité: un demi-siècle de sociabilité à Piura (1850-1900

Directory of Open Access Journals (Sweden)

1994-01-01

Full Text Available L’auteur aborde ici un thème encore peu étudié par les historiens latino-américanistes : la sociabilité urbaine au XIXe siècle. Il dresse un panorama général de la vie collective - et plus particulièrement de la vie associative - à Piura entre 1850 et 1900, en se basant sur une série quasi continue de périodiques publiés localement à cette même époque, qui permettent de définir les principaux domaines d’activités publiques ainsi que les préoccupations majeures des citoyens de la ville (pratiques spirituelles entraide et bienfaisance lieux de réunion et de divertissement civisme et patriotisme vie politique. L’analyse de ces sources montre que si certaines formes de sociabilité trouvent leur origine dans la période coloniale et illustrent une relative continuité dans la tradition, d’autres correspondent à une capitale régionale en pleine mutation. En effet, à partir du milieu du XIXe siècle Piura reçoit de plus en plus de modèles extérieurs et s’adapte pour maintenir un certain équilibre entre les aspirations - parfois contradictoires - de ses habitants et la nécessité de répondre aux changements sociaux, culturels et économiques auxquels la collectivité est confrontée. Cette dernière n’est bien sûr pas constituée d’un bloc uniforme, et si presque tous les groupes sociaux paraissent représentés à travers ces associations et lieux de sociabilité, les différentes réponses apportées à une même préoccupation (l’entraide et la bienfaisance, par exemple peuvent varier considérablement selon le groupe considéré. En outre cette étude met en lumière les connexions et les interactions constatées entre des manifestations de sociabilité correspondant pourtant à des activités théoriquement distinctes. De même, elle souligne le rôle de cohésion sociale joué par certaines de ces manifestations (fête nationale cérémonies patriotiques meetings politiques célébrations religieuses

L'idéal de l'immigration européenne dans la Colombie du XIXe siècle: du rêve civilisateur à la peur de la subversion

Directory of Open Access Journals (Sweden)

1996-01-01

Full Text Available Parmi les multiples outils de “civilisation” à la portée des dirigeants latino-américains du siècle dernier, l’immigration européenne s’imposa évidemment comme un des plus attirants, de par son caractère concret : au lieu d’importer des normes, il s’agissait d’importer des hommes “civilisés”, en chair et en os. Dans la course à l’immigration, qui caractérise la culture politique du XIXe siècle latino-américain, la Colombie se distingue par son incapacité à réaliser ce rêve. Malgré les échecs répétés des tentatives officielles, les groupes dirigeants débattent, tout au long du siècle des bienfaits et des dangers de l’immigration les plans d’immigration mis en oeuvre par les différentes tendances politiques qui se succèdent au pouvoir cristallisent leurs projets idéologiques. Les projets immigrationnistes, tout autant qu’ils révèlent les fluctuations de la perception de l’Europe, reflètent à merveille les différentes versions de l’idéal “civilisateur” des élites colombiennes. Mais l’absence de dynamique interne, l’inexistence d’un réel besoin de main-d’oeuvre, la fragilité des circuits étatiques, qui s’ajoutent aux obstacles évidents du pays - faible niveau d’activité économique, insuffisante intégration au marché international, difficulté de lutter contre la concurrence de pays plus prometteurs comme les États-Unis ou l’Argentine - achèveront d’enterrer l’idéal d’une immigration “civilisatrice”. EL IDEAL DE LA INMIGRACIÓN EUROPEA EN EL SIGLO XIX COLOMBIANO: DEL SUEÑO CIVILIZADOR AL MIEDO A LA SUBVERSIÓN. Entre las distintas herramientas de “civilización” al alcance de los dirigentes latinoamericanos del siglo XIX, la inmigración europea apareció evidentemente como una de las más deseables, por ser la más concreta: en vez de importar normas, se importarían hombres “civilizados”, de carne y hueso. En la carrera a la inmigración europea, que caracteriza la

Real time diagnosis of bladder cancer with probe-based confocal laser endomicroscopy

Science.gov (United States)

Liu, Jen-Jane; Wu, Katherine; Adams, Winifred; Hsiao, Shelly T.; Mach, Kathleen E.; Beck, Andrew H.; Jensen, Kristin C.; Liao, Joseph C.

2011-02-01

Probe-based confocal laser endomicroscopy (pCLE) is an emerging technology for in vivo optical imaging of the urinary tract. Particularly for bladder cancer, real time optical biopsy of suspected lesions will likely lead to improved management of bladder cancer. With pCLE, micron scale resolution is achieved with sterilizable imaging probes (1.4 or 2.6 mm diameter), which are compatible with standard cystoscopes and resectoscopes. Based on our initial experience to date (n = 66 patients), we have demonstrated the safety profile of intravesical fluorescein administration and established objective diagnostic criteria to differentiate between normal, benign, and neoplastic urothelium. Confocal images of normal bladder showed organized layers of umbrella cells, intermediate cells, and lamina propria. Low grade bladder cancer is characterized by densely packed monomorphic cells with central fibrovascular cores, whereas high grade cancer consists of highly disorganized microarchitecture and pleomorphic cells with indistinct cell borders. Currently, we are conducting a diagnostic accuracy study of pCLE for bladder cancer diagnosis. Patients scheduled to undergo transurethral resection of bladder tumor are recruited. Patients undergo first white light cystocopy (WLC), followed by pCLE, and finally histologic confirmation of the resected tissues. The diagnostic accuracy is determined both in real time by the operative surgeon and offline after additional image processing. Using histology as the standard, the sensitivity, specificity, positive and negative predictive value of WLC and WLC + pCLE are calculated. With additional validation, pCLE may prove to be a valuable adjunct to WLC for real time diagnosis of bladder cancer.

Technologie pour le forage scientifique en eau très profonde au XXIe siècle Deepwater Technology for Scientific Drilling in the 21st Century

Directory of Open Access Journals (Sweden)

Sparks C.

2006-11-01

Full Text Available Le présent article aborde les slimline risers et les systèmes de forage minier qui sont deux domaines technologiques dont le potentiel doit permettre d'améliorer le forage et le carottage scientifiques en eau très profonde au cours du XXIe siècle. Cet article présente les avantages et les inconvénients des slimline risers, par rapport aux risers de forage utilisés par l'industrie pétrolière. Le potentiel de matériaux nouveaux est évoqué. Des analyses préliminaires de slimline risers fabriqués de différents matériaux (acier, titane, aluminium et composite pour forage scientifique par 4 000 m de profondeur d'eau sont présentées. La seconde partie de l'article aborde les moyens d'adapter les systèmes de forage minier aux grands fonds. This paper addresses slimline riser systems and mining drilling systems which are two items of technology that have the potential to improve scientific drilling and coring in deep water in the 21st century. The paper presents the advantages and disadvantages of drilling with a slimline riser, compared to an oil industry riser. The potential of new materials are discussed. Preliminary analyses of slimline risers made from different materials (steel, titanium, aluminium and composite for 4000 m of water are presented. In the second part of the paper, ways of adapting mining systems to deepwater are discussed.

CT assessment of subtypes of pulmonary emphysema in females

International Nuclear Information System (INIS)

Togami, Taro; Yamamoto, Yuka; Kameyama, Reiko; Murota, Makiko; Kimura, Naruhide; Nishiyama, Yoshihiro; Satoh, Katashi

2011-01-01

We performed a retrospective study examining the prevalence and subtypes of pulmonary emphysema (PE) identified by computed tomography (CT) in females. We reviewed the records of 1,687 female subjects who had undergone CT. They were divided into the following 2 age groups: group A (<50 years) and group B (≥50 years). PE was diagnosed by the presence of low-attenuation areas using visual assessment (grades 0-3) on CT images. Two subtypes of PE were observed: centrilobular emphysema (CLE) and paraseptal emphysema (PSE). PE was divided into the following 3 categories: I (CLE or CLE-predominant); II (CLE and PSE of equal extent); and III (PSE or PSE-predominant). PE was found in 64 of 274 smokers (23.3%) and 54 of 1,413 non-smokers (3.8%). In smoking subjects, when grades 1 and 2 were grouped together as mild PE, the mean age for CT grade 3 (severe PE) was significantly higher than that for mild PE. In group A, category III predominated, whereas category I was more prevalent in group B, in both smoking and non-smoking subjects. A high incidence of PE was found in smoking subjects as compared with non-smoking subjects. PSE predominated in younger subjects, whereas CLE predominated in older subjects. (author)

Influences of Sociocultural Factors Within the Clinical Learning Environment on Students' Perceptions of Learning: An Integrative Review.

Science.gov (United States)

Jessee, Mary Ann

A persistent deficit in new graduate nurses' clinical reasoning skill exists. Clinical reasoning is best learned in the sociocultural clinical learning environment (CLE), yet many CLEs fail to engage nursing students in the cognitive work of nursing that promotes development of clinical reasoning. Despite two decades of recommendations to improve CLEs based on students' perceptions of learning, widespread improvement remains elusive. The aim of this review was to synthesize what is known about the influence of sociocultural factors in the acute-care CLE on prelicensure nursing students' perceptions of learning, for the purpose of identifying factors that when modified may promote improvement of clinical reasoning skill. The integrative review methodology was used to synthesize and identify gaps in evidence on students' perceptions of learning in the acute-care CLE. Global commonalities exist in the impact of the sociocultural CLE on students' perceptions of learning, including overall sociocultural atmosphere, membership in the health care team, supervisory relationships, peer relationships, and clinical education structure. This review provides evidence that modification of CLE factors and examination of their influence on measurable learning outcomes such as clinical reasoning are the necessary next steps to facilitate improvement of new graduate nurses' clinical reasoning skill. Copyright © 2016 Elsevier Inc. All rights reserved.

Bronchial provocation testing does not detect exercise-induced laryngeal obstruction.

Science.gov (United States)

Walsted, Emil Schwarz; Hull, James H; Sverrild, Asger; Porsbjerg, Celeste; Backer, Vibeke

2017-01-02

Exercise-induced laryngeal obstruction (EILO) is a key differential diagnosis for asthma in the presence of exertional respiratory symptoms. Continuous laryngoscopy during exercise (CLE), the current gold standard diagnostic test for EILO, has practical limitations. We aimed to establish if inspiratory flow data obtained during standard bronchoprovocation testing, to establish the presence of extra-thoracic hyper-responsiveness, may prove diagnostic for EILO and thus preclude requirement for CLE testing. We consecutively evaluated 37 adult subjects with exertional dyspnea and possible asthma referred over 6 months. All subjects received comprehensive assessment including a detailed clinical evaluation; pulmonary function testing, indirect and direct bronchial provocation testing, and CLE testing. Out of 37 subjects, moderate or severe EILO was diagnosed in 8 subjects (22%, all female) while 5 (14%) had both asthma and EILO. There was no correlation between degree of EILO during CLE and mean decrease in forced inspiratory flow (%FIF 50 ) obtained during neither the Methacholine (r = -0.15; p = 0.38) nor Mannitol (r = 0.04; p = 0.84) provocation tests. Inspiratory flow parameters obtained during bronchoprovocation tests did not reliably detect EILO. It remains that CLE is an important and key investigation modality in establishing a secure diagnosis of EILO.

Les Rȇves de la Fée Verte : L’absinthe dans les romans de la deuxième moitié du XIXe siècle (Dreams of The Green Fairy: Absinthe in The Novels of The Second Half of The 19th Century

Directory of Open Access Journals (Sweden)

Eva Voldřichová Beránková

2016-09-01

Full Text Available Fabricated from the end of the 18th century, popularized after 1830 by French soldiers returning from Algeria, crowned the green fairy of the Parisian boulevards around 1860, the absinthe dominates the fin-de-siècle imagination as the principal means of transport “anywhere out of the world”. This article resumes the paradoxical mythology of this beverage that appears in French novels in the second half of the 19th century. Octave Féré, Jules Cauvain and the Goncourt brothers give a warning against its pernicious power, while Emile Zola’s attitude to the absinthe is more ambiguous. The magical potential of the green fairy seems to be tempting the father of naturalism who mixes science and mythology, the probable and the grotesque, the strict laws of heredity and the supernatural lightness of a blue flame coming from the “spontaneous combustion”.

Building a platform for scientific-research cooperation under circumstances of realized asymmetry of potential

Directory of Open Access Journals (Sweden)

Wiśniowski Witold

2016-12-01

Full Text Available Growing complexity of the environment arising both from the processes of globalization in world economy and from the development processes in Poland has become a strategic challenge for the Institute of Aviation. Significant disproportions of the potential of Poland, compared to Germany, United States, or China (especially in terms of the economic dimension and the adopted model for financing scientific research, as well as distant position of Polish universities on the scientific map of the world lead to the necessity to create a model for managing the Institute of Aviation based on internationalization of research and cooperation with leading scientific and (Ohio State University – OSU technological centres (General Electric – GE. The experiences of the Institute of Aviation show that what should be the basis of international competitiveness of research institutes is well educated scientific personnel, modern research infrastructure and competences of cooperation. A proof of this is 16-year-long strategic alliance (private-public partnership of the Institute and GE, cooperation with OSU and activities in European research consortia. The innovative dimension of scientific cooperation with OSU (2+2 formula, research internships, commission for predicting new directions of scientific research and other foreign partners allows the Institute of Aviation to achieve success in competition of international character.

Concentrated Language Encounter Approach in Practice for Global Teaching of Literacy: Lighthouse Strategy Implementation

Science.gov (United States)

Rattanavich, Saowalak

2015-01-01

This article presents the lighthouse literacy strategies model using the concentrated language encounter (CLE) approach that has been successfully replicated in many countries in different languages and cultures. A review of CLE research studies and the project implementation in Thailand showed highly significant results in students' literacy…

Synergistic interaction of CLAVATA1, CLAVATA2, and RECEPTOR-LIKE PROTEIN KINASE 2 in cyst nematode parasitism of Arabidopsis

Science.gov (United States)

Plant-parasitic cyst nematodes secrete CLAVATA3 (CLV3)/ENDOSPERM SURROUNDING REGION (ESR) (CLE)-like effector proteins. These proteins act as ligand mimics of plant CLE peptides and are required for successful nematode infection. Previously, we showed that CLV2 and CORYNE (CRN), a heterodimer recept...

Confocal laser endomicroscopy

DEFF Research Database (Denmark)

Karstensen, John Gásdal; Săftoiu, Adrian; Brynskov, Jørn

2016-01-01

BACKGROUND AND STUDY AIMS: Confocal laser endomicroscopy (CLE) has been shown to predict relapse in ulcerative colitis in remission, but little is currently known about its role in Crohn's disease. The aim of this study was to identify reproducible CLE features in patients with Crohn's disease...

Computational Process Modeling for Additive Manufacturing (OSU)

Science.gov (United States)

Bagg, Stacey; Zhang, Wei

2015-01-01

Powder-Bed Additive Manufacturing (AM) through Direct Metal Laser Sintering (DMLS) or Selective Laser Melting (SLM) is being used by NASA and the Aerospace industry to "print" parts that traditionally are very complex, high cost, or long schedule lead items. The process spreads a thin layer of metal powder over a build platform, then melts the powder in a series of welds in a desired shape. The next layer of powder is applied, and the process is repeated until layer-by-layer, a very complex part can be built. This reduces cost and schedule by eliminating very complex tooling and processes traditionally used in aerospace component manufacturing. To use the process to print end-use items, NASA seeks to understand SLM material well enough to develop a method of qualifying parts for space flight operation. Traditionally, a new material process takes many years and high investment to generate statistical databases and experiential knowledge, but computational modeling can truncate the schedule and cost -many experiments can be run quickly in a model, which would take years and a high material cost to run empirically. This project seeks to optimize material build parameters with reduced time and cost through modeling.

Confocal Laser Endomicroscopy for the Diagnosis of Urothelial Carcinoma in the Bladder and the Upper Urinary Tract: Protocols for Two Prospective Explorative Studies.

Science.gov (United States)

Liem, Esmee Iml; Freund, Jan Erik; Baard, Joyce; de Bruin, D Martijn; Laguna Pes, M Pilar; Savci-Heijink, C Dilara; van Leeuwen, Ton G; de Reijke, Theo M; de la Rosette, Jean Jmch

2018-02-07

Visual confirmation of a suspicious lesion in the urinary tract is a major corner stone in diagnosing urothelial carcinoma. However, during cystoscopy (for bladder tumors) and ureterorenoscopy (for tumors of the upper urinary tract) no real-time histopathologic information can be obtained. Confocal laser endomicroscopy (CLE) is an optical imaging technique that allows for in vivo high-resolution imaging and may allow real-time tumor grading of urothelial lesions. The primary objective of both studies is to develop descriptive criteria for in vivo CLE images of urothelial carcinoma (low-grade, high-grade, carcinoma in situ) and normal urothelium by comparing CLE images with corresponding histopathology. In these two prospective clinical trials, CLE imaging will be performed of suspicious lesions and normal tissue in the urinary tract during surgery, prior to resection or biopsy. In the bladder study, CLE will be performed in 60 patients using the Cystoflex UHD-R probe. In the upper urinary tract study, CLE will be performed in 25 patients during ureterorenoscopy, who will undergo radical treatment (nephroureterectomy or segmental ureter resection) thereafter. All CLE images will be analyzed frame by frame by three independent, blinded observers. Histopathology and CLE-based diagnosis of the lesions will be evaluated. Both studies comply with the IDEAL stage 2b recommendations. Presently, recruitment of patients is ongoing in both studies. Results and outcomes are expected in 2018. For development of CLE-based diagnosis of urothelial carcinoma in the bladder and the upper urinary tract, a structured conduct of research is required. This study will provide more insight in tissue-specific CLE criteria for real-time tumor grading of urothelial carcinoma. Confocal Laser Endomicroscopy: ClinicalTrials.gov NCT03013894; https://clinicaltrials.gov /ct2/show/NCT03013894?term=NCT03013894&rank=1 (Archived by WebCite at http://www.webcitation.org/6wiPZ378I); and Dutch Central

Séries de problèmes dans une tradition d'enseignement des mathématiques en Hongrie au 20e siècle1

Directory of Open Access Journals (Sweden)

Gosztonyi Katalin

2015-01-01

Full Text Available Dans cet article, nous discutons l'intérêt d'étudier des « séries de problèmes » pour la caractérisation d'une tradition d'enseignement des mathématiques en Hongrie au 20e siècle. Dans la partie 1, nous résumons le contexte historique et les principes partagés dans cette tradition sur les mathématiques et leur enseignement. Dans la partie 2, nous étudions plus en détail un texte d'un membre de cette communauté, un extrait du Jeux avec l'infini de Rózsa Péter, qui nous servira de modèle pour les analyses ultérieures. Dans la partie 3, nous présentons différents documents liés à la réforme de l'enseignement des mathématiques dirigée par Tamás Varga dans les décennies 1960 et 1970, cette réforme étant considérée comme une étape significative dans l'histoire de cette « tradition hongroise ». Nous tenterons de montrer qu'une réflexion sur la mise en ordre des problèmes joue un rôle crucial dans la structuration de ces textes divers, écrits souvent dans une forme narrative et quasi-littéraire ; et que l'étude des « séries de problèmes » présentées dans ces textes peut apporter une contribution importante à la caractérisation de la tradition en question.

La Géographie de l'Au-delà dans la littérature médiévale anglaise

OpenAIRE

Alamichel , Marie-Françoise

2010-01-01

International audience; Reprise de l'introduction de l'article:Les cartes médiévales les plus détaillées du monde – comme la célèbre Hereford map du tout début du XIVe siècle, celle préservée à la Huntington Library (Californie) illustrant le Polychronicon de Ranulf Higden (fin XIVe siècle) ou la petite Psalter World Map d’un psautier du XIIe siècle conservé à la British Library – comportent toutes une représentation du Paradis terrestre, font figurer des contrées merveilleuses peuplées de mo...

Congenital lobar emphysema: Is surgery routinely necessary ...

African Journals Online (AJOL)

Congenital lobar emphysema (CLE) is a rare congenital abnormality characterised by overinflation of a pulmonary lobe. Its aetiology is unknown. The management of CLE has traditionally been surgical. A newborn boy with a birthweight of 2.5 kg was delivered at full-term by caesarian section due to food delivery.

Lanterna Magica. De Brusselse Sint-Hubertusgalerijen als ontmoetingsplek

NARCIS (Netherlands)

Arnout, A.M.G.; Pater, Ben de; Sintobin, Tom; Vandevoorde, Hans

2017-01-01

This contribution focuses on the Galeries Saint-Hubert as a meeting place in fin de siècle Brussels. With their luxurious shops, societies and coffee houses, arcades had become important meeting places for the bourgeoisie in many fin de siècle cities. In this contribution, I argue that

Les dissidentes baptistes à travers les livres d’Église du xviie siècle anglais

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Anne Dunan-Page

2009-07-01

Full Text Available Cet article propose une étude de quelques livres d’Église tenus par des communautés dissidentes baptistes dans la seconde moitié du xviie siècle. Ces livres ont été souvent négligés par les historiens étant donnée la nature lacunaire des informations qu’ils contiennent et leur diversité générique. Après un survol de la littérature de controverse et des nombreuses satires à l’encontre des dissidentes, nous montrons comment cette littérature peut être nuancée grâce aux informations contenues dans les livres d’Église manuscrits. Certains historiens ont développé une vision optimiste des multiples opportunités offertes aux dissidentes dans les assemblées séparatistes. Les livres d’Église présentent des preuves appelant à une révision de cette position. À travers des analyses du rôle des femmes et des rares cas où elles étaient autorisées à s’exprimer devant les assemblées, se révèlent une extrême résistance et un fort conservatisme à l’égard de la parole féminine de la part des pasteurs et des anciens. Même au sein des communautés dissidentes qui pourtant réservaient un accueil favorable aux femmes, ces dernières ne parvenaient pas toujours à braver les interdits bibliques concernant la prise de parole dans l’Église.  This article examines some early Baptist Church Books from the second half of the seventeenth century. They have been generally neglected by historians because the records they contain are often imperfect, and the nature of the information varies so much from one book to the next. After a general presentation of the pamphlet and satirical literature published against dissenting women, I show how this literature may be read in the light of the manuscript Church Books. In recent years, other kinds of evidence have encouraged historians towards a more optimistic view of women’s opportunities in the Baptist Churches. The Church Books present a much more sobering picture

Diffuse Attenuation Coef. K490, Aqua MODIS, 0.125 degrees, Indonesia

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — OSU distributes Diffuse Attenuation Coefficient at 490 nm Wavelength data from NASA's Aqua satellite. Measurements are gathered by the Moderate Resolution Imaging...

Dietary intake of Arsenic, Iodine and Selenium by adolescents in three Orphanages in Southern Ghana using Radiochemical Neutron activation analysis

International Nuclear Information System (INIS)

Adotey, K. D.

2011-07-01

Adolescents require optimum dietary supply of the essential trace minerals iodine (I) and selenium (Se). Their dietary exposure to arsenic (As), due to its natural presence in the diet, should be at levels that provides ample safety. Due to the late recognition of the critical nature of adolescent nutrition, there is scarce and almost non-existence of data on the adolescents dietary intake of As, I and Se; making it difficult for public health nutritionists to assess the adequacy of the dietary intake. The absence of data has also adversely affected the formulation of policies on adolescent nutrition and its integration into existing nutrition and health care programmes in Ghana. The dietary intake of As, I and Se for adolescents (12-15years) in three residential care orphanages, (Osu, Tutu- Akwapim, and Teshie), in Southern Ghana, have been evaluated by sampling their 24- hour total duplicate diets (including water) for 7-consecutive days using the duplicate diet sampling technique. The mass fraction of As, I and Se in the pooled blended lyophilized homogenates of duplicate diets was determined by radiochemical neutron activation analysis (RNAA). The validity of the RNAA methods for As, I and Se determinations were respectively checked by analyses of NIST SRM 1548a (Typical Diet). The chemical yields (recovery of the respective radiochemical separation of As, I and Se were 90- 92%, 83-88%, and 78-85%. The mass fraction of arsenic in the lyophilized diets for Osu, Tutu-Akwapim and Teshie were 134 ± 104 [46-240], 146 ± 87 [39-355], and 189 ± 123 [69-348] ng As g -1 lyophilized matter. The dietary exposures to As were 47 ± 23 [17-84], 58 ± 44 [16-125] and 67 ± 28 [24-117] μg As day -1 for Osu, Tutu-Akwapim and Teshie orphanages respectively. The mass fraction of I in the lyophilized diets were 287 ± 95 [206-397], 286 ± 109 [201-386], and 961 ± 142 [588-1766] ng I g -1 lyophilized matter, for Osu, Tutu-Akwapim and Teshie respectively. The dietary intake of I

Interactive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoids on proliferation and differentiation in cultured human keratinocytes: quantification of cross-linked envelope formation

International Nuclear Information System (INIS)

Berkers, J.A.M.; Hassing, I.; Spenkelink, B.; Brouwer, A.; Blaauboer, B.J.

1995-01-01

Dioxins are potent inducers of chloracne in humans. This skin aberration can be interpreted as an altered differentiation pattern of acinar sebaceous base cells and a change in the rate of terminal differentiation of the keratinocytes. We measured this rate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in primary cultures of human keratinocytes. As parameters for differentiation, we quantified the 35 S-methionine incorporation into cross-linked envelopes (revealing the total CLE biomass), as well as the number of microscopically visible CLEs. It was shown that TCDD is a very potent inducer of both CLE biomass and number with a half-maximal effect concentration (EC 50 ) of 1.4 nM. CLE biomass was maximally increased 10-fold and the number of cells in culture producing a CLE was increased from 15% in control cultures to maximally 75% of the cells in TCDD-treated cultures. Both effects were Ca 2+ -dependent and increased with elevated cell density, being optimal in post-confluent cultures. Retinoic acid dose-dependently decreased the effect of 10 -8 M TCDD, 10 -6 M having a nearly complete antagonistic action. This interaction of retinoic acid with TCDD-induced differentiation was non-competitive. Retinol was equally potent as an antagonist of the TCDD-induced elevation of CLE formation as compared with retinoic acid. Retinyl palmitate and etretinate were not very effective as TCDD antagonists. Supplementation of hydrocortisone suppressed the TCDD-induced keratinocyte differentiation. It was concluded that CLE biomass quantification provides a reliable and sensitive parameter for keratinocyte differentiation. In this in vitro system it is shown that TCDD strongly induces a switch from proliferation to terminal differentiation and that this effect can be antagonized effectively by retinoic acid and retinol. (orig.)

Église Saint-Pierre-Saint-Paul, Appoigny (Yonne

Directory of Open Access Journals (Sweden)

Fabrice Henrion

2009-09-01

Full Text Available L’église Saint-Pierre-Saint-Paul d’Appoigny témoigne d’un important chantier du début du XIIIe siècle , mais les sources permettent d’envisager la présence d’un sanctuaire au moins depuis l’extrême fin du VIe siècle. En effet, le règlement liturgique établit par Aunaire, évêque d’Auxerre de 561 à 604, mentionne Epponiacus dans la liste des sanctuaires auxerrois, sans que le vocable de l’église d’Appoigny ne soit précisé. Par ailleurs, depuis au moins le IXe siècle, une tradition, reprise par ...

Problems connected with the production of highly specific antisera against prostaglandin E2 (PGE2) and prostaglandin A2 (PGA2) for radioimmunoassay

International Nuclear Information System (INIS)

Kopp, H.G.; Vetter, W.; Siegenthaler, W.

1977-01-01

To obtain sensitive and specific antisera against PGE 2 and PGA 2 these substances were coupled to thyroglobulin (Tg). Coupling reactions were either performed by using a hydroxysuccinimideester as intermediate step leading to a complex carrying 170 mol PGE 2 per mol Tg ('PGE 2 -OSU-Tg') and 240 mol PGA 2 per mol Tg ('PGA 2 -OSU-Tg') or alternatively by using N,N'-carbonyl-diimidazole resulting in 'PGE 2 -CDI-Tg' (400 mol PGE 2 per mol Tg) and 'PGA 2 -CDI-Tg' (600 mol PGA 2 per mol Tg). Two tracer systems ( 3 H-prostaglandin, 125 I-histamine-prostaglandin) were used for analysis of antibody activity. Both PGE 2 - and PGA 2 -CDI-Tg complexes were poor immunogens in rabbits. The PGE 2 - and PGA 2 -OSU-Tg conjugates were injected both in rabbits and in guinea pigs. These two compounds resulted in very high antibody titers in both animal species. However, in guinea pigs markedly higher antibody sensitivity and antibody specificity were observed than in rabbits. Our results indicate that the guinea pig may be the animal of choice for immunization against prostaglandins. Antibody specificity of guinea pig antisera may be perhaps high enough to measure the concentration of PGE 2 and PGA 2 in the presence of other prostaglandins or prostaglandin metabolites. (orig.) [de

Globally covering a-priori regional gravity covariance models

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D. Arabelos

2003-01-01

Full Text Available Gravity anomaly data generated using Wenzel’s GPM98A model complete to degree 1800, from which OSU91A has been subtracted, have been used to estimate covariance functions for a set of globally covering equal-area blocks of size 22.5° × 22.5° at Equator, having a 2.5° overlap. For each block an analytic covariance function model was determined. The models are based on 4 parameters: the depth to the Bjerhammar sphere (determines correlation, the free-air gravity anomaly variance, a scale factor of the OSU91A error degree-variances and a maximal summation index, N, of the error degree-variances. The depth of Bjerhammar-sphere varies from -134km to nearly zero, N varies from 360 to 40, the scale factor from 0.03 to 38.0 and the gravity variance from 1081 to 24(10µms-22. The parameters are interpreted in terms of the quality of the data used to construct OSU91A and GPM98A and general conditions such as the occurrence of mountain chains. The variation of the parameters show that it is necessary to use regional covariance models in order to obtain a realistic signal to noise ratio in global applications.Key words. GOCE mission, Covariance function, Spacewise approach`

Current meter components and other data from FIXED PLATFORMS as part of the World Ocean Circulation Experiment (WOCE) from 1992-02-26 to 1993-04-14 (NODC Accession 9700264)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Current meter components data were collected from FIXED PLATFORMS. Data were collected by Oregon State University (OSU) as part of the World Ocean Circulation...

Validity and reliability of grade scoring in the diagnosis of exercise-induced laryngeal obstruction

DEFF Research Database (Denmark)

Walsted, Emil Schwarz; Hull, James H; Hvedstrup, Jeppe

2017-01-01

The current gold-standard method for diagnosing exercise-induced laryngeal obstruction (EILO) is continuous laryngoscopy during exercise (CLE), with severity classified by a visual grade scoring system. We evaluated the precision of this approach, by evaluating test-retest reliability of CLE...... grade scoring system does not appear to be a robust means for reliably classifying severity of EILO....

Le désordre du monde

African Journals Online (AJOL)

sulaiman.adebowale

Le début du XXIe siècle se caractérise par l'accumulation et la consécution ..... Unis a présidé à la naissance aux forceps de cet outil d'équilibre du monde en ... De toute évidence, l'ONU reste l'instrument qui a marqué le siècle dernier,.

Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions.

Science.gov (United States)

Gheorghe, C; Iacob, R; Dumbrava, Mona; Becheanu, G; Ionescu, M

2009-01-01

Confocal LASER endomicroscopy (CLE) is a newly developed endoscopic technique which allows subsurface in vivo histological assessment during ongoing endoscopy and targeted biopsies. Ultrasound endoscopy (EUS) is a useful tool in staging upper GI malignant lesions. We describe for the first time the use of both techniques during the same endoscopic session, in a pilot study, in order to increase the diagnostic yield of histological assessment and provide the staging of the gastric neoplastic lesions thus decreasing the time to therapeutic decision. CLE has been performed with the Pentax EG-3870CIK confocal endomicroscope after a 5 ml intravenous 10% fluorescein injection; EUS has been performed subsequently, during the same endoscopic Propofol sedation session, using a standard radial EUS-scope. Eleven patients have been investigated, 4 females, 7 males, mean age 59.7 +/- 12.3 years. The indication of CLE/EUS exploration was the presence of a gastric polypoid lesion in 37% of cases, atypical gastric ulcer in 27% of patients, gastric lymphoma 18%, suspicion of gastric cancer recurrence after resection 9% and infiltrating type gastric cancer 9%. Histological assessment after targeted biopsy has established the diagnosis of gastric adenocarcinoma in 55% of cases, gastric lymphoma in 18% of cases, gastric adenoma, gastric GIST and gastric foveolar hyperplasia in 9% of cases respectively. CLE has allowed targeted biopsies in 81.8% of cases. In 2 patients - one case with suspected recurrent gastric cancer after surgery and one case of gastric lymphoma, CLE has indicated normal gastric mucosa. The EUS evaluation has shown TO lesion in two cases, T1 in 3 cases, T2 in 3 cases, T3 in one case. The EUS evaluation showed in one gastric lymphoma patient a lesion interesting the mucosa and submucosa with regional adenopathy and a submucosal lesion with regional adenopathy in the other gastric lymphoma case. The therapeutic decision was surgery in 73% of cases, chemotherapy and

Bajo el signo de Licurgo: el reformismo atávico de Agis IV y Cleómenes III = Under the sign of Lycurgus: the atavistic reformism of Agis IV and Cleomenes III

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César Fornis

2016-04-01

Full Text Available En el presente estudio se abordan los intentos de reforma en Esparta por los reyes Agis IV y Cleómenes III, que ambos, con finalidad legitimadora, presentaron como una recuperación atávica del kósmos (orden atribuido al legendario Licurgo, aquel que había formado ciudadanos virtuosos y sobre el que se había asentado el glorioso pasado de la ciudad. Se concluye que sus medidas no atacaron las raíces de los males que corroían la polis lacedemonia ni transformaron de modo significativo las vetustas estructuras sociales, políticas y económicas para adaptarlas a los nuevos tiempos, los del Helenismo.In this paper we analyze the attempts of reform of the Spartan state by the kings Agis IV and Cleomenes III. With legitimizing purpose, they presented them as an atavistic recovery of the kosmos (order ascribed to the legendary Lycurgus, which had formed to the citizens in moral virtues and which had settled the glorious past of the city. We conclude that these measures did not attack the roots of the evils corroding the Lacedaimonian polis or significantly transformed the old social, political and economic structures in order to adapt them to the new times, those of the Hellenism. 

Natural dye sensitizer from cassava (Manihot utilissima) leaves extract and its adsorption onto TiO2 photo-anode

Science.gov (United States)

Nurlela; Wibowo, R.; Gunlazuardi, J.

2017-04-01

Interaction between TiO2 and dyes sensitizer have been studied. The chlorophyll presents in the crude leave extract (CLE-dye) from cassava (Manihot utilissima) was immobilized on to the photo-anode, consists of TiO2 supported by fluor doped Tin oxide (SnO2-F) Glass. The TiO2 was prepared by Rapid Breakdown Anodization (RBA) method then immobilized on to glass coated by SnO2-F using doctor blade technique, to give CLE-dye/TiO2/SnO2-F/Glass photo-anode. The prepared photo-anode was characterized by UV-Vis-DRS, FTIR, XRD, SEM, electrochemical and spectro-electrochemical systems. In this study, the HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) energy level of the CLE-dye were empirically determined by cyclic voltammetry method, while spectro-electro-chemistry method was used to determine the coefficient of degradation and formation of the dyes, and diffusion coefficient of the hole recombination as well. Good anchoring between TiO2 with dye extracts (CLE-dye) can be seen from value of dye LUMO energy level (-4.26 eV), which is approaching the conduction band of TiO2 (-4.3 eV). The coefficient of degradation and formation of the CLE-dye showed a quasi reversible and diffusion coefficient hole recombination values were small, indicated that it is quite suitable as a sensitizer in a dyes sensitized solar cell.

Prognostic implications of active discoid lupus erythematosus and malar rash at the time of diagnosis of systemic lupus erythematosus: Results from a prospective cohort study.

Science.gov (United States)

Drucker, A M; Su, J; Mussani, F; Siddha, S K; Gladman, D D; Urowitz, M B

2016-04-01

Cutaneous lupus erythematosus (CLE) may have prognostic implications for systemic lupus erythematosus (SLE). We aimed to determine the impact of discoid lupus erythematosus (DLE) and malar rash on SLE disease activity. Data were analyzed from the Toronto Lupus Clinic prospective cohort study. We compared SLE patients with active DLE or malar rash at SLE diagnosis to SLE patients who never developed CLE. Outcomes were assessed at one and five years, including Adjusted Mean Systemic Lupus Erythematosus Disease Activity Index 2000 (AMS). A total of 524 SLE patients (284 without CLE, 65 with DLE, and 175 with malar rash) were included. Mean AMS scores in patients without CLE at one and five years were 5.96 ± 5.06 and 4.00 ± 3.52, which did not differ significantly from scores at one (6.93 ± 5.31, p = 0.17) and five years (4.29 ± 2.62, p = 0.63) in the DLE group. In patients with malar rash, AMS scores at one (8.30 ± 6.80, p < 0.001) and five years (5.23 ± 3.06, p = 0.004) were higher than controls without CLE. Malar rash may be a marker of more severe systemic disease over time, while DLE has no significant impact on general SLE disease activity. © The Author(s) 2015.

Effective deep learning training for single-image super-resolution in endomicroscopy exploiting video-registration-based reconstruction.

Science.gov (United States)

Ravì, Daniele; Szczotka, Agnieszka Barbara; Shakir, Dzhoshkun Ismail; Pereira, Stephen P; Vercauteren, Tom

2018-06-01

Probe-based confocal laser endomicroscopy (pCLE) is a recent imaging modality that allows performing in vivo optical biopsies. The design of pCLE hardware, and its reliance on an optical fibre bundle, fundamentally limits the image quality with a few tens of thousands fibres, each acting as the equivalent of a single-pixel detector, assembled into a single fibre bundle. Video registration techniques can be used to estimate high-resolution (HR) images by exploiting the temporal information contained in a sequence of low-resolution (LR) images. However, the alignment of LR frames, required for the fusion, is computationally demanding and prone to artefacts. In this work, we propose a novel synthetic data generation approach to train exemplar-based Deep Neural Networks (DNNs). HR pCLE images with enhanced quality are recovered by the models trained on pairs of estimated HR images (generated by the video registration algorithm) and realistic synthetic LR images. Performance of three different state-of-the-art DNNs techniques were analysed on a Smart Atlas database of 8806 images from 238 pCLE video sequences. The results were validated through an extensive image quality assessment that takes into account different quality scores, including a Mean Opinion Score (MOS). Results indicate that the proposed solution produces an effective improvement in the quality of the obtained reconstructed image. The proposed training strategy and associated DNNs allows us to perform convincing super-resolution of pCLE images.

Une masculinité en crise à la fin du XVIIe siècle ? La critique de l'efféminé chez La Bruyère

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Cédric Corgnet

2008-07-01

Full Text Available L’efféminé est toujours un cas sexuel limite : homme aux airs féminins, il interroge l’innée de la nature sexuelle, critique les genres et leur définition explicitement physique. La fin du XVIIe siècle illustre cette tension chez les moralistes français et surtout chez La Bruyère dans ses Caractères où celui-ci interroge cette monstruosité générique à travers une analyse sémiologique. Mais cette tératologie n’est pas avant tout clinique mais sociale et morale : il nous avertit, par cet écart de genre, d’une corruption morale du monde tant par une sémiologie clinique que mythologique ovidienne ne cherchant pas le réalisme pathologique mais la filiation antique qui ante son ouvrage sur les Caractères Théophrastiens : philosophe plus que naturaliste.The effeminate is always a sexual limit case: man in the feminine sights, he questions the innate of the sexual nature, criticizes genders and their explicitly physical definition. The end of the XVIIth century illustrates this tension at the French moralists and especially in La Bruyère’s Characters where this one questions this generic monstrousness through a semiological analysis. But this teratology is not above all clinical but social and moral: he warns us, by this distance from gender, from a moral corruption of the world both by a clinical semiology and ovidian mythology not looking for the pathological realism but the antic filiation with Theophrast’s Characters : philosopher more than naturalist.

Compilation of ocean circulation and other data from ADCP current meters, CTD casts, tidal gauges, and other instruments from a World-Wide distribution by Oregon State University and other institutions as part of World Ocean Circulation Experiment (WOCE) and other projects from 24 November 1985 to 30 December 2000 (NODC Accession 0000649)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Compilation of ocean circulation and other data were collected from a World-Wide distribution by Oregon State University (OSU) and other institutions as part of...

International Relations as Group Interaction: The Case of Russia and NATO

Science.gov (United States)

2016-05-01

Olivier Kempf, L’OTAN Au XXIe Siècle: La Transformation D’un Héritage, Histoire et Société (Perpignan: Artège, 2010), 277 4 Founding Act on Mutual...Press, 1976. Kempf, Olivier. L’OTAN Au XXIe Siècle: La Transformation D’un Héritage. Histoire et Société. Perpignan: Artège, 2010. Khong, Yuen Foong

Relative impacts of worldwide tropospheric ozone changes and regional emission modifications on European surface-ozone levels

International Nuclear Information System (INIS)

Szopa, S.; Hauglustaine, D.A.

2007-01-01

Multi-scale models were applied to assess the surface ozone changes in 2030. Several emission scenarios are considered, ranging from (a) a pessimistic anthropogenic emission increase to (b) an optimistic decrease of emissions, and including (c) a realistic scenario that assumes the implementation of control legislations [CLE]. The two extreme scenarios lead respectively to homogeneous global increase and decrease of surface ozone, whereas low and inhomogeneous changes associated with a slight global increase of ozone are found for the CLE scenario. Over western Europe, for the CLE scenario, the benefit of European emission reduction is significantly counterbalanced by increasing global ozone levels. Considering warmer conditions over Europe and future emission modifications, the human health exposure to surface ozone is found to be significantly worsened. (authors)

Human colorectal mucosal microbiota correlates with its host niche physiology revealed by endomicroscopy.

Science.gov (United States)

Wang, Ai-Hua; Li, Ming; Li, Chang-Qing; Kou, Guan-Jun; Zuo, Xiu-Li; Li, Yan-Qing

2016-02-26

The human gut microbiota plays a pivotal role in the maintenance of health, but how the microbiota interacts with the host at the colorectal mucosa is poorly understood. We proposed that confocal laser endomicroscopy (CLE) might help to untangle this relationship by providing in vivo physiological information of the mucosa. We used CLE to evaluate the in vivo physiology of human colorectal mucosa, and the mucosal microbiota was quantified using 16 s rDNA pyrosequencing. The human mucosal microbiota agglomerated to three major clusters dominated by Prevotella, Bacteroides and Lactococcus. The mucosal microbiota clusters did not significantly correlate with the disease status or biopsy sites but closely correlated with the mucosal niche physiology, which was non-invasively revealed by CLE. Inflammation tilted two subnetworks within the mucosal microbiota. Infiltration of inflammatory cells significantly correlated with multiple components in the predicted metagenome, such as the VirD2 component of the type IV secretory pathway. Our data suggest that a close correlation exists between the mucosal microbiota and the colorectal mucosal physiology, and CLE is a clinically available tool that can be used to facilitate the study of the in vivo correlation between colorectal mucosal physiology and the mucosal microbiota.

CURRENT DIRECTION, WIND GUST and other data from FIXED PLATFORM from 1974-02-23 to 1974-04-25 (NCEI Accession 7601418)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Current meter and other data were collected from fixed platforms from 23 February 1974 to 25 April 1974. Data were collected by Oregon State University (OSU) as part...

Current and other data from fixed platforms as part of the International Decade of Ocean Exploration / International Ocean Studies / First Dynamic Response and Kinematics Experiment in the Drake Passage (IDOE/ISOS/FDRAKE) from 1979-01-13 to 1980-02-01 (NODC Accession 8700085)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Current and other data were collected from fixed platforms from 13 January 1979 to 01 February 1980. Data were collected by Oregon State University (OSU) as part of...

Perception of and satisfaction with the clinical learning environment among nursing students.

Science.gov (United States)

D'Souza, Melba Sheila; Karkada, Subrahmanya Nairy; Parahoo, Kader; Venkatesaperumal, Ramesh

2015-06-01

Clinical nursing education provides baccalaureate nursing students an opportunity to combine cognitive, psychomotor, and affective skills in the Middle East. The aim of the paper is to assess the satisfaction with and effectiveness of the clinical learning environment among nursing students in Oman. A cross-sectional descriptive design was used. A convenience sample consisting of 310 undergraduate nursing students was selected in a public school of nursing in Oman. Ethical approval was obtained from the Research and Ethics Committee, College of Nursing in 2011. A standardized, structured, validated and reliable Clinical Learning Environment Supervision Teacher Evaluation instrument was used. Informed consent was obtained from all the students. Data was analyzed with ANOVA and structural equation modeling. Satisfaction with the clinical learning environment (CLE) sub-dimensions was highly significant and had a positive relationship with the total clinical learning environment. In the path model 35% of its total variance of satisfaction with CLE is accounted by leadership style, clinical nurse commitment (variance=28%), and patient relationships (R(2)=27%). Higher age, GPA and completion of a number of clinical courses were significant in the satisfaction with the CLE among these students. Nurse educators can improvise clinical learning placements focusing on leadership style, premises of learning and nursing care, nurse teacher, and supervision while integrating student, teacher and environmental factors. Hence the clinical learning environment is integral to students' learning and valuable in providing educational experiences. The CLE model provides information to nurse educators regarding best clinical practices for improving the CLE for BSN students. Copyright © 2015 Elsevier Ltd. All rights reserved.

Copy Right for Flight: Patterns of Technological Adaptation in Military Aviation

Science.gov (United States)

2012-06-01

Massicotte and Claude Lessard, Histoire du Sport, de L’antiquité au Xixe Siècle (Sillery, Québec: Presses de l’Université du Québec, 1984), 129. 4...Massicotte, Jean-Paul, and Claude Lessard. Histoire du Sport, de L’antiquité au Xixe Siècle. Sillery, Québec: Presses de l’Université du Québec

La peinture religieuse monumentale, une expression artistique emblématique du nord de la France au XIXe siècle ?

Directory of Open Access Journals (Sweden)

Catherine Guillot

2012-04-01

Full Text Available Issue d’une première tentative de synthèse portant sur la peinture monumentale religieuse à Lille dans la seconde moitié du XIXe siècle, cette étude permet d’exhumer l’œuvre d’artistes régionaux, mais également belges et néerlandais, mettant en évidence le rôle de carrefour de l’actuelle métropole lilloise. Dans une région fortement marquée par le catholicisme, les sujets traités sont à la fois le reflet des dévotions nationales et de cultes plus locaux, que ce soit à travers la figure de saint Vincent de Paul, le rôle de la Vierge ou la dévotion aux âmes du purgatoire qui prend une importance particulière à partir du foyer de Loos. Cette expression artistique et religieuse se développe sous la forme de grands cycles dont la réalisation connaît son apogée sous la IIIe République, en particulier de 1880 à 1900. Une fois ce panorama dressé, il devient possible d’interroger les catégories traditionnelles de l’art à cette époque, la notion centrale de primitivisme et les jugements de valeur auxquels cette peinture est encore souvent soumise.This article is based on a synthetic analysis of monumental religious painting at Lille during the second half of the 19th century. This study led to the rediscovery of many regional artists, but also Belgian and Dutch artists, underlining the long history of Lille’s present-day position as an international crossroads. In a region which was strongly marked by Catholicism, the subjects dealt with offer a reflection of national devotional practices but also draw attention to more local cults. Examples here include the figure of Saint Vincent de Paul, the role of the Virgin Mary and the devotion to souls in purgatory, which is particularly important in Loos. This artistic and religious expression develops according to major cycles which reached a high point during the Third Republic, and particularly from 1880 to 1890. Once this general overview has been established

Dosimetry implications of BSH biodistribution study at OSU

International Nuclear Information System (INIS)

Gupta, N.; Albertson, B.J.; Gahbauer, R.A.; Barth, R.F.; Goodman, J.H.

2000-01-01

A BSH biodistribution study was performed at Ohio State University, where tumor, normal brain, and blood boron concentrations of patients undergoing tumor debulking surgery were acquired. The results of this biodistribution study are subjects of other presentations in this meeting. In this paper, we present an overview of the dosimetry implications of this biodistribution data. The analysis for this paper assumed that the tumor boron RBE was factor of two higher than the normal brain boron RBE. Our conclusions from this analysis were that with the tumor/blood ratios observed in our patients for times of up to 14 hours post commencement of boron infusion, one could not successfully treat patients with BNCT using BSH. (author)

OSU Reactor Sharing Program FY 1995 annual report

International Nuclear Information System (INIS)

Higginbotham, J.F.

1996-10-01

This is the annual report of the activities supported under the Oregon State University Reactor Sharing Program, award number DE-FG06-NE38137. The beginning date for the award was September, 30, 1995 and the end date was September 29, 1996. Work conducted under this award is internally administered at the Radiation Center through a project tasking system. This allows for excellent quality control for the work which is performed from the point of initial contact, through the reactor application, project report generation and financial accounting. For the current fiscal year, FY95, the total cost of the reactor sharing program, including Radiation Center contributions, was $66,323.20 of which $40,000.00 was supplied by the DOE Reactor Sharing Program. The details of individual project costs is given in Table 1. The work performed for the individual projects are described in the brief work descriptions given in Table 2

A decision support system for transportation infrastructure and supply chain system planning.

Science.gov (United States)

2013-07-01

This project makes the results (models and methodology) of the research and development efforts on freight movement modeling (FMM) and supply chain design carried out by faculty at OSU and OU available to transportation and logistics professionals. A...

Germinação de sementes de porta-enxertos de citros após o armazenamento em ambiente refrigerado Seed germination of citrus rootstocks after cooling conditions storage

Directory of Open Access Journals (Sweden)

DALMO LOPES DE SIQUEIRA

2002-08-01

Full Text Available Este trabalho teve como objetivo avaliar o período de viabilidade das sementes dos porta-enxertos limoeiros-'Cravo' e 'Volkameriano', tangerineira-'Cleópatra' e citrumeleiro-'Swingle' armazenadas em embalagem permeável sob temperatura controlada de 5-7ºC por 150 dias. A cada 30 dias, foram avaliadas a germinação em laboratório e a emergência das plântulas em casa de vegetação. Determinou-se o grau de umidade das sementes em cada época de testes. O armazenamento nas condições citadas induziu menor velocidade de germinação nas sementes de 'Cravo' e 'Volkameriano', as quais não tiveram a germinação prejudicada quando apresentavam umidade próxima a 5%. Houve correlação altamente significativa entre teor de água e germinação nas sementes de 'Cleópatra' e 'Swingle'. Para a manutenção da viabilidade das sementes destes porta-enxertos, deve-se procurar manter o seu grau de umidade em torno de 20%. As sementes dos limoeiros-'Cravo' e 'Volkameriano' apresentaram maior velocidade de germinação e emergência que os demais porta-enxertos, enquanto as da tangerineira-'Cleópatra' apresentaram menor velocidade de emergência. Sementes de citrumeleiro- 'Swingle' e tangerineira-'Cleópatra' não germinaram após armazenamento por 60 e 90 dias, respectivamente.The present work was carried out in order to verify the viability period of the rootstocks 'Rangpur' lime, 'Volkameriano' lemon, 'Cleópatra' mandarin and 'Swingle' citrumelo seeds stored in permeable package at 5-7ºC for 150 days. The Germination in laboratory, seedling emergence in greenhouse and seed moisture content were performed each 30 days. Seed storage in that conditions reduced the speed of emergence index in the 'Rangpur' and 'Volkameriano' seeds. The germination of these rootstocks seeds weren't reduced when the seed moisture content was near 5%. There was highly significative correlation between seed water content and germination porcentage of 'Cleópatra' and

La « Nouvelle Mosquée » d’Alger. Le déroulement d’une procédure constructive au xviie siècle

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Samia Chergui

2012-01-01

Full Text Available « La Nouvelle Mosquée » est érigée, à la fin du xviie siècle, dans la seule perspective de doter le rite hanéfite de sa propre Grande Mosquée. Cette nouvelle édification relève, à l’évidence, d’une procédure collective exceptionnelle, celle qu’entreprend la milice d’Alger, en l’occurrence le corps des janissaires, en puisant dans les fonds des Subul al-Khayrât. L’examen du livre de comptes qu’avait tenu cette institution ḥabûs, responsable de la gestion de la plupart des mosquées hanéfites et de leurs awqâf, aussitôt après le lancement du chantier, a permis de suivre le déroulement des travaux sur une période de presque dix années, soit de 1067/1656-1657 à 1076/1665-1666. Ce rôle de chantier apporte des éclairages significatifs notamment sur la nature, la provenance, la quantité et le coût des matériaux employés à la construction. Ils ne manquent pas non plus de documenter les aspects concernant leur fabrication, voire leur préparation, et quelque rares fois leur mise en œuvre ; une mise en œuvre qui, ici, revient à la dextérité de nombreux hommes, mobilisés dans le cadre corporatif. La comptabilité salariale, tenue en cette occasion, compte d’ailleurs parmi les rares initiatives de gestion qui ont permis, durant au moins une décennie, de consigner les plus amples détails non seulement sur le profil distinctif de l’ensemble de ces intervenants, mais également sur leur origine géographique, voire confessionnelle.

Physical profile data from CTD casts in the coastal Western U.S. and NE Pacific (limit-180) from the R/V WECOMA in support of Global Ocean Ecosystem Dynamics (GLOBEC) from 2001-04-18 to 2001-12-11 (NODC Accession 0000747)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Physical profile data were collected from CTD casts in the Gulf of Alaska from the R/V Wecoma. Data were collected by Oregon State University (OSU) in support of the...

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African Journals Online (AJOL)

... The content of mineral elements on whole blood and hair in Moschus sifanicus .... Vol 10, No 26 (2011), The effect of Aloe vera extract on humoral and cellular ... OSU-142 inoculation at various levels of nitrogen fertilization on growth, tuber ...

Towards the chiral metabolomics: Liquid chromatography–mass spectrometry based DL-amino acid analysis after labeling with a new chiral reagent, (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate, and the application to saliva of healthy volunteers

Energy Technology Data Exchange (ETDEWEB)

Mochizuki, Toshiki; Takayama, Takahiro; Todoroki, Kenichiro; Inoue, Koichi; Min, Jun Zhe; Toyo’oka, Toshimasa, E-mail: toyooka@u-shizuoka-ken.ac.jp

2015-05-22

Highlights: • A novel chiral labeling reagent was synthesized. • Analysis of DL-amino acids was performed by UPLC–ESI-MS/MS. • Efficient enantioseparation and detection of DL-amino acids were performed. • DL-Amino acid in saliva was successfully determined under mild conditions. - Abstract: A novel triazine-type chiral derivatization reagent, i.e., (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate (DMT-(S)-Pro-OSu), was developed for the highly sensitive and selective detection of chiral amines and amino acids by UPLC–MS/MS analysis. The enantiomers of amino acids were easily labeled with the reagents at room temperature within 40 min in an alkaline medium containing triethylamine. The diastereomers derived from proteolytic amino acids, except serine, were well separated under isocratic elution conditions by reversed-phase chromatography using an ODS column (R{sub s} = 1.2–9.0). DL-Serine was separated by use of an ADME column which has relatively higher polar surface than the conventional ODS column. The characteristic product ions, i.e., m/z 195.3 and m/z 209.3, were detected from all the diastereomers by the collision-induced dissociation of the protonated molecule. A highly sensitive detection on the amol–fmol level was obtained from the selected reaction monitoring (SRM) chromatogram. The chiral amines (e.g., adrenaline and noradrenaline) labeled with DMT-(S)-Pro-OSu were also well separated and sensitively detected by the present procedure. The method using DMT-(S)-Pro-OSu was used for the determination of DL-amino acids in the human saliva from healthy volunteers. Various L-amino acids were identified in the saliva. Furthermore, D-alanine (D-Ala) and D-proline (D-Pro) were also detected in relatively high concentrations (>5%). The ratio was higher in male saliva than in female saliva. However, the difference in the ratio of D-Ala for one day was not very high and the effect of foods and beverage

Drug-induced cutaneous lupus erythematosus

DEFF Research Database (Denmark)

Laurinaviciene, Rasa; Holm Sandholdt, Linda; Bygum, Anette

2017-01-01

BACKGROUND: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time. OBJECTIVES......: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor. MATERIALS & METHODS: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period. We registered clinical......, serological, and histological data with a focus on drug intake. RESULTS: Of 775 consecutive patients with a diagnosis of lupus erythematosus (LE) or suspected LE, a diagnosis of CLE could be confirmed in 448 patients. A total of 130 patients had a drug intake that could suggest DI-SCLE. In 88 cases, a drug...

National Pesticide Information Center

Science.gov (United States)

... How can I protect my pets when using pesticides around them? More FAQs FAQ Comics Video FAQs From NPIC: Fact Sheets Videos Web Apps Podcasts Outreach Materials NPIC Professional Resources Social Media: National Pesticide Information Center Tweets by NPICatOSU Please read our ...

Modification of an Existing In vitro Method to Predict Relative Bioavailable Arsenic in Soils

Science.gov (United States)

The soil matrix can sequester arsenic (As) and reduces its exposure by soil ingestion. In vivo dosing studies and in vitro gastrointestinal (IVG) methods have been used to predict relative bioavailable (RBA) As. Originally, the Ohio State University (OSU-IVG) method predicted R...

Congenital lobar emphysema in neonates: Anaesthetic challenges

Directory of Open Access Journals (Sweden)

Mridu Paban Nath

2011-01-01

Full Text Available Congenital lobar emphysema (CLE is a potentially reversible, though possibly life-threatening, cause of respiratory distress in the neonate. It poses dilemma in diagnosis and management. We are presenting a 6-week-old baby who presented with a sudden onset of respiratory distress related to CLE affecting the left upper lobe. Lobectomy was performed under general anaesthesia with one lung ventilation. The details of anaesthetic challenges and management are described here.

Ten-year utilization of the Oregon State University TRIGA Reactor (OSTR)

International Nuclear Information System (INIS)

Ringle, John C.; Anderson, Terrance V.; Johnson, Arthur G.

1978-01-01

The Oregon State University TRIGA Reactor (OSTR) has been used heavily throughout the past ten years to accommodate exclusively university research, teaching, and training efforts. Averages for the past nine years show that the OSTR use time has been as follows: 14% for academic and special training courses; 44% for OSU research projects; 6% for non-OSU research projects; 2% for demonstrations for tours; and 34% for reactor maintenance, calibrations, inspections, etc. The OSTR has operated an average of 25.4 hours per week during this nine-year period. Each year, about 20 academic courses and 30 different research projects use the OSTR. Visitors to the facility average about 1,500 per year. No commercial radiations or services have been performed at the OSTR during this period. Special operator training courses are given at the OSTR at the rate of at least one per year. (author)

Using Open Source Tools to Create a Mobile Optimized, Crowdsourced Translation Tool

Directory of Open Access Journals (Sweden)

Evviva Weinraub Lajoie

2014-04-01

Full Text Available In late 2012, OSU Libraries and Press partnered with Maria's Libraries, an NGO in Rural Kenya, to provide users the ability to crowdsource translations of folk tales and existing children's books into a variety of African languages, sub-languages, and dialects. Together, these two organizations have been creating a mobile optimized platform using open source libraries such as Wink Toolkit (a library which provides mobile-friendly interaction from a website and Globalize3 to allow for multiple translations of database entries in a Ruby on Rails application. Research regarding successes of similar tools has been utilized in providing a consistent user interface. The OSU Libraries & Press team delivered a proof-of-concept tool that has the opportunity to promote technology exploration, improve early childhood literacy, change the way we approach foreign language learning, and to provide opportunities for cost-effective, multi-language publishing.

An Investigation of Collaborative Leadership

Science.gov (United States)

2013-01-01

has made it difficult to focus on value added collaborative endeavors. Problem Statement Several articles and books have described the theory of...Model carmenwiki.osu.edu/display/libraries/Definition+of+Collaboration Dixon, P. (1999). Nietzsche and Jung: Sailing a deeper night. New York: P. Lang

77 FR 12313 - Food Labeling Workshop; Public Workshop

Science.gov (United States)

2012-02-29

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Food Labeling Workshop; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of... District Office (DALDO), in collaboration with Oklahoma State University (OSU), Robert M. Kerr Food...

Final report of “A Detailed Study of the Physical Mechanisms Controlling CO2-Brine Capillary Trapping in the Subsurface” (University of Arizona, DE-SC0006696)

Energy Technology Data Exchange (ETDEWEB)

Schaap, Marcel G. [Univ. of Arizona, Tucson, AZ (United States)

2016-07-25

Carbon capture and storage (CCS) of carbon dioxide emissions generated by production or combustion of fossil fuels is a technologically viable means to reduce the build-up of CO2 in the atmosphere and oceans. Using advantages of scale and location, CCS is particularly suitable for large point sources near ubiquitous deep saline aquifers, depleted gas reservoirs, or at production reservoirs for enhanced oil recovery (EOR). In the BES-funded research project, Oregon State University (OSU) carried out capillary trapping experiments with proxy fluids that mimic the properties of the scCO2/brine system under ambient temperatures and pressures, and successfully developed a unique and novel x-ray compatible, high-pressure, elevated temperature setup to study the scCO2/brine system under challenging reservoir conditions. Both methodologies were applied to a variety of porous media, including synthetic (glass bead) and geologic (Bentheimer sandstone) materials. The University of Arizona (UA) developed pore-scale lattice Boltzmann (LB) models which are able to handle the experimental conditions for proxy fluids, as well as the scCO2/brine system, that are capable of simulating permeability in volumes of tens of millions of fluid elements. We reached the following summary findings (main institute indicated): 1. (OSU/UA) To understand capillary trapping in a multiphase fluid-porous medium system, the system must be analyzed from a pore-scale force balance perspective; trapping can be enhanced by manipulating wetting and nonwetting phase fluid properties. 2. (OSU) Pore-scale fluid connectivity and topology has a clear and direct effect on nonwetting phase capillary trapping efficiency. 3. (OSU) Rock type and flow regime also have a pronounced effects on capillary trapping. 4. (OSU/UA) There is a predictable relationship between NWP connectivity and NWP saturation, which allows for development of injection strategies that optimize trapping. The commonly used Land model (Land

Nietzsche l'islam et la globalisation | Monia | African Sociological ...

African Journals Online (AJOL)

le printemps arabe », ou les révolutions du siècle, se sont déclenchées avec une aspiration d'un monde sous développé a la liberté, la modernité et la démocratie. Les faits nous mènent vers un total détournement des buts de ce « printemps arabe ». Obscurantisme, islamisme, jihad, théocratie s'installent. Le siècle exprime ...

Fossil plants from Romanian deposits of Bacles, Dolj District, Romania

Directory of Open Access Journals (Sweden)

Nicolae T̡icleanu

2001-09-01

Full Text Available From the Middle Romanian lacustrine deposits of the Oltenia province, the authors describe the youngest fossil flora known until now in Oltenia. The inventory of the fossil flora includes the following taxa: Taxodium dubium, ?Platanus platanifolia, Ulmus laevis, Quercus roburoides, Q. cf. muehlenbergii, Carya serraefolia, Acer cf. tricuspidatum and Salix sp. In the Bâcleş fossil flora, Glyptostrobus europaeus, which is a thermophilous and shows a high frequency in all Oltenia area till the XV-th coal seam, is absent. Consequently, having in view the high frequency of Taxodium dubium, which indicate temperate climate conditions, the other consider that the fossil flora from Bâcleş is much more younger and marks an important cooling. From palaeofloristic point of view, the study of Bâcleş fossil flora is indicative for river meadow forest and, probably, flat plain forest environments.

EUS-Guided Needle-Based Confocal Laser Endomicroscopy

DEFF Research Database (Denmark)

Bhutani, Manoop S; Koduru, Pramoda; Joshi, Virendra

2015-01-01

Endoscopic ultrasound (EUS) has emerged as an excellent tool for imaging the gastrointestinal tract, as well as surrounding structures. EUS-guided fine-needle aspiration (EUS-FNA) has become the standard of care for the tissue sampling of a variety of masses and lymph nodes within and around...... the gut, providing further diagnostic and staging information. Confocal laser endomicroscopy (CLE) is a novel endoscopic method that enables imaging at a subcellular level of resolution during endoscopy, allowing up to 1000-fold magnification of tissue and providing an optical biopsy. A new procedure...... that has been developed in the past few years is needle-based confocal laser endomicroscopy (nCLE), which involves a mini-CLE probe that can be passed through a 1 9-gauge needle during EUS-FNA. This enables the real-time visualization of tissue at a microscopic level, with the potential to further improve...

Setting ozone critical levels for protecting horticultural Mediterranean crops: Case study of tomato

International Nuclear Information System (INIS)

González-Fernández, I.; Calvo, E.; Gerosa, G.; Bermejo, V.; Marzuoli, R.; Calatayud, V.; Alonso, R.

2014-01-01

Seven experiments carried out in Italy and Spain have been used to parameterising a stomatal conductance model and establishing exposure– and dose–response relationships for yield and quality of tomato with the main goal of setting O 3 critical levels (CLe). CLe with confidence intervals, between brackets, were set at an accumulated hourly O 3 exposure over 40 nl l −1 , AOT40 = 8.4 (1.2, 15.6) ppm h and a phytotoxic ozone dose above a threshold of 6 nmol m −2 s −1 , POD6 = 2.7 (0.8, 4.6) mmol m −2 for yield and AOT40 = 18.7 (8.5, 28.8) ppm h and POD6 = 4.1 (2.0, 6.2) mmol m −2 for quality, both indices performing equally well. CLe confidence intervals provide information on the quality of the dataset and should be included in future calculations of O 3 CLe for improving current methodologies. These CLe, derived for sensitive tomato cultivars, should not be applied for quantifying O 3 -induced losses at the risk of making important overestimations of the economical losses associated with O 3 pollution. -- Highlights: • Seven independent experiments from Italy and Spain were analysed. • O 3 critical levels are proposed for the protection of summer horticultural crops. • Exposure- and flux-based O 3 indices performed equally well. • Confidence intervals of the new O 3 critical levels are calculated. • A new method to estimate the degree risk of O 3 damage is proposed. -- Critical levels for tomato yield were set at AOT40 = 8.4 ppm h and POD6 = 2.7 mmol m −2 and confidence intervals should be used for improving O 3 risk assessment

Technician-Supported Remote Interrogation of CIEDs: Initial Use in US Emergency Departments and Perioperative Areas.

Science.gov (United States)

Ahmed, Imdad; Patel, Amisha S; Balgaard, Timothy J; Rosenfeld, Lynda E

2016-03-01

Interrogation/interpretation of cardiac implantable electronic devices (CIEDs) is frequently required in the emergency department (ED) or perioperative areas (OR) where resources to do this are often not available. CareLink Express (CLE; Medtronic, plc, Mounds View, MN, USA) is a technician-supported real-time remote interrogation system for Medtronic CIEDs. Using data from 136 US locations, this retrospective study was designed to assess CLE efficiency compared to traditional device management, and examine its findings. All 7,044 US CLE transmissions from the ED and OR (January 2012-October 2014) were compared to 217 traditional requests where CIED interrogations/interpretations were performed by calling industry representatives to these sites. CLE reduced the time to device interrogation/interpretation by 78%: 100 ± 140-22 ± 14 minutes, P < 0.0001, improving response time and consistency; ED: 82 ± 103-23 ± 18 minutes, P, ≤ 0.01; OR: 127 ± 181-17 ± 10 minutes, P < 0.0001. Actionable events (AE) (arrhythmia, device/lead abnormalities) were infrequent: 9.1% overall (ED: 9.9%; OR: 4.1%). Only 6.5% of patients with syncope/presyncope and 13.6% with a perceived shock had AE. AEs were more common in those with suspected device problems (30.4%) or audible alerts (52.6%). They were more likely in patients not enrolled in long-term remote monitoring (23.9% vs 8.2%, P < 0.0001) and in those with older CIED systems (7.4% in year 1 vs 31.0% after 10 years). The many patients with CIEDs, and the ability to quickly identify the minority with high-risk AE from the no/low-risk majority, strongly support CLE use in the ED and OR, sites which are expensive and prioritize efficiency. © 2015 Wiley Periodicals, Inc.

Efficiency of the confocal method of laser endomicroscopy in complex diagnoses of diseases of common bile duct

International Nuclear Information System (INIS)

Anaskin, S G; Korniletsky, I D; Panchenkov, D N; Chertyuk, V B; Sazonov, D V; Zabozlayev, F G; Danilevskaya, O V; Mokshina, N V

2017-01-01

One of the more frequent manifestations of diseases of the bile ducts are its’ strictures or stenoses that could be of either malignant or benign nature. Current methods of diagnosing this pathology include computer tomography (CT) scan, magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP). However, these methods are not always informative, which makes this a current and topical problem. A fundamentally new method that broadens the capabilities of ERCP when diagnosing diseases of the bile duct accompanied by the development of strictures or stenoses is probe-based confocal laser endomicroscopy (pCLE). The method is based on the principle of confocal fluorescence microscopy. The most elaborate complications arise with the presence of the pre-existing pancreatobiliary pathology: pseudotumoral chronic pancreatitis, acute cholangitis, etc. Early stage cholangiocarcinoma diagnosis can be difficult (and not always possible) even with the help of modern research methods. For the timely diagnostic it is advantageous to conduct pCLE and targeted biopsy of the zone with most manifested changes. In all instances, the first use of the pCLE method for diagnostic purposes allowed us to clarify and correctly verify the diagnosis. When concerning the diseases of the bile duct, the modern stage of pCLE development can be of critical importance when other methods are not effective. (paper)

Les demandes d'enfermement dans la généralité de Rouen au xviiie siècle : le récit de vie comme objet d'Histoire

Directory of Open Access Journals (Sweden)

Élise Chopin-Tufel

2009-10-01

Full Text Available Á travers quelques exemples normands de la seconde moitié du xviiie siècle, cet article analyse la construction des dossiers de demandes d’enfermement et les raisons qui poussent les familles à demander des ordres du roi pour enfermer l’un des leurs. Ces documents présentent des particularités (manque de spontanéité, fragmentation des récits narratifs qui doivent être prises en compte dans leur étude. Ils sont cependant d’une grande richesse pour aborder les réseaux sociaux, les normes et transgressions dans la société normande prérévolutionnaire. Le concept d’identité narrative développé par Paul Ricœur enrichit l’étude de ces sources. Á travers la narration, les justiciables normands mobilisent en effet différentes identités qui renseignent sur les rapports qu’ils entretiennent avec le politique.Through Norman examples from the second half of the 18th century, this article analyses the structure of confinement requests cases and the reasons why families used lettres de cachet to lock up one of their folks. Those documents show particularities (a lack of spontaneity, a fragmentation in the narrative that must be considered when studying them. However they are very useful to study social networks as well as the standards and contraventions of this prerevolutionary Norman society. This concept of a 'narrative identity' as developped by Paul Ricœur enriches the study of these sources. Through narration, Normans who are to be tried use different identities, which give information about their relations with politics.

Partnership to Improve Nutrient Efficiency

Science.gov (United States)

PINE began in 2013 by working with OSU Extension and producers to locate and test existing 1990s lysimeters in Benton, Linn and Lane counties. The team identified additional producers to install Prenart lysimeters at a total of 15 sites. Producers allow for soil and water samplin...

77 FR 59404 - Food Defense; Public Workshop

Science.gov (United States)

2012-09-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001... Regional Office (SWRO), in co-sponsorship with Oklahoma State University (OSU), Robert M. Kerr Food... workshop will be held at the Robert M. Kerr Food & Agricultural Products Center, Oklahoma State University...

Cyber Security--Are You Prepared?

Science.gov (United States)

Newman, Scott

2007-01-01

During the summer 2002 term, Oklahoma State University-Okmulgee's Information Technologies Division offered a one credit-hour network security course--which barely had adequate student interest to meet the institution's enrollment requirements. Today, OSU-Okmulgee boasts one of the nation's premier cyber security programs. Many prospective…

Ce que l’itinéraire nous dit du voyage. Listes d’itinéraire, voyage et imaginaire spatial au Soudan central au XIXe siècle What itineraries tells us about travels. Lists of itinerary, travels and the geographical imagery of central Sudan during the 19th century

Directory of Open Access Journals (Sweden)

Camille Lefebvre

2011-02-01

Full Text Available Les explorateurs européens qui parcourent le Soudan central dans la première moitié du xixe siècle concentrent leurs recherches sur la collecte d’informations géographiques, afin de réunir les matériaux nécessaires à la construction de cartes une fois rentrés en Europe. Pour ce faire, leur méthode est celle d’un recueil systématique et quotidien d’itinéraires auprès de leurs compagnons de voyage et d’informateurs croisés sur les routes ou à l’étape. Certaines de ces listes d’itinéraires nous sont parvenues et nous invitent à tenter de retrouver les pratiques savantes et les imaginaires spatiaux qui les fondent. En les confrontant à des matériaux linguistiques recueillis eux aussi au xixe siècle, on peut replacer ces itinéraires dans le contexte des pratiques de voyage de cette époque au Soudan central. La confrontation de ces documents permet de proposer une mise en récit réaliste des processus qui se sont noués au moment de la rencontre et de donner ainsi du sens à ces objets hybrides, reflets des conceptions de l’espace alors en usage au Soudan central.The European explorers who traveled in the central Sudan during the first half of the 19th century concentrated on gathering the geographical information necessary for drawing maps once they would return to Europe. Their method involved a daily, systematic account of the trips made by the companions and informants whom they met on the road or at places where they stopped over. Some of these lists of itineraries have survived and invite us to try to describe the scientific practices and geographical imagery on which they were based. By comparing them with linguistic data collected during the 19th century, we can place these itineraries in the context of traveling at the time in the central Sudan. This comparison enables us to propose a realistic account of the processes involved in these meetings and to give meaning to these hybrid reflections of the

Learning From Where Students Look While Observing Simulated Physical Phenomena

Science.gov (United States)

Demaree, Dedra

2005-04-01

The Physics Education Research (PER) Group at the Ohio State University (OSU) has developed Virtual Reality (VR) programs for teaching introductory physics concepts. Winter 2005, the PER group worked with OSU's cognitive science eye-tracking lab to probe what features students look at while using our VR programs. We see distinct differences in the features students fixate on depending upon whether or not they have formally studied the related physics. Students who first make predictions seem to fixate more on the relevant features of the simulation than those who do not, regardless of their level of education. It is known that students sometimes perform an experiment and report results consistent with their misconceptions but inconsistent with the experimental outcome. We see direct evidence of one student holding onto misconceptions despite fixating frequently on the information needed to understand the correct answer. Future studies using these technologies may prove valuable for tackling difficult questions regarding student learning.

Scaling Studies for High Temperature Test Facility and Modular High Temperature Gas-Cooled Reactor

Energy Technology Data Exchange (ETDEWEB)

Richard R. Schult; Paul D. Bayless; Richard W. Johnson; James R. Wolf; Brian Woods

2012-02-01

The Oregon State University (OSU) High Temperature Test Facility (HTTF) is an integral experimental facility that will be constructed on the OSU campus in Corvallis, Oregon. The HTTF project was initiated, by the U.S. Nuclear Regulatory Commission (NRC), on September 5, 2008 as Task 4 of the 5-year High Temperature Gas Reactor Cooperative Agreement via NRC Contract 04-08-138. Until August, 2010, when a DOE contract was initiated to fund additional capabilities for the HTTF project, all of the funding support for the HTTF was provided by the NRC via their cooperative agreement. The U.S. Department of Energy (DOE) began their involvement with the HTTF project in late 2009 via the Next Generation Nuclear Plant (NGNP) project. Because the NRC's interests in HTTF experiments were only centered on the depressurized conduction cooldown (DCC) scenario, NGNP involvement focused on expanding the experimental envelope of the HTTF to include steady-state operations and also the pressurized conduction cooldown (PCC).

Bronchial provocation testing does not detect exercise-induced laryngeal obstruction

DEFF Research Database (Denmark)

Walsted, Emil Schwarz; Hull, James H; Sverrild, Asger

2017-01-01

INTRODUCTION: Exercise-induced laryngeal obstruction (EILO) is a key differential diagnosis for asthma in the presence of exertional respiratory symptoms. Continuous laryngoscopy during exercise (CLE), the current gold standard diagnostic test for EILO, has practical limitations. We aimed...... to establish if inspiratory flow data obtained during standard bronchoprovocation testing, to establish the presence of extra-thoracic hyper-responsiveness, may prove diagnostic for EILO and thus preclude requirement for CLE testing. METHODS: We consecutively evaluated 37 adult subjects with exertional dyspnea...

Confocal endomicroscopy for in vivo microscopic analysis of upper gastrointestinal tract premalignant and malignant lesions.

Science.gov (United States)

Gheorghe, Cristian; Iacob, Razvan; Becheanu, Gabriel; Dumbrav Abreve, Mona

2008-03-01

Confocal LASER endomicroscopy (CLE) is a new endoscopic technique which allows subsurface in vivo microscopic analysis during ongoing endoscopy, using systemically or topically administered fluorescent agents. It allows targeted biopsies to be taken, potentially improving the diagnostic rate in certain gastrointestinal diseases. Worldwide experience with CLE for upper gastrointestinal malignant and premalignant lesions is still reduced. Potential clinical applications are presented, including diagnosis of NERD, Barrett's esophagus, atrophic gatritis, gastric intestinal metaplasia and dysplasia, gastric adenomatous or hyperplastic polyps, gastric cancer.

Molecular confocal laser endomicroscopy

DEFF Research Database (Denmark)

Karstensen, John Gásdal; Klausen, Pia Helene; Saftoiu, Adrian

2014-01-01

While flexible endoscopy is essential for macroscopic evaluation, confocal laser endomicroscopy (CLE) has recently emerged as an endoscopic method enabling visualization at a cellular level. Two systems are currently available, one based on miniprobes that can be inserted via a conventional...... during on-going endoscopy), a novel world of molecular evaluation opens up. The method of molecular CLE could potentially be used for estimating the expression of important receptors in carcinomas, subsequently resulting in immediate individualization of treatment regimens, but also for improving...

Human mortality effects of future concentrations of tropospheric ozone

International Nuclear Information System (INIS)

West, J.; Szopa, S.; Hauglustaine, D.A.

2007-01-01

Here we explore the effects of projected future changes in global ozone concentrations on premature human mortality, under three scenarios for 2030. We use daily surface ozone concentrations from a global atmospheric transport and chemistry model, and ozone-mortality relationships from daily time-series studies. The population-weighted annual average 8-h daily maximum ozone is projected to increase, relative to the present, in each of ten world regions under the SRES A2 scenario and the current legislation (CLE) scenario, with the largest growth in tropical regions, while decreases are projected in each region in the maximum feasible reduction (MFR) scenario. Emission reductions in the CLE scenario, relative to A2, are estimated to reduce about 190,000 premature human mortalities globally in 2030, with the most avoided mortalities in Africa. The MFR scenario will avoid about 460,000 premature mortalities relative to A2 in 2030, and 270,000 relative to CLE, with the greatest reductions in South Asia. (authors)

76 FR 15952 - National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric; Public Meeting

Science.gov (United States)

2011-03-22

... the data and discuss possible explanations; and (4) identify data gaps and future research.... or as necessary to complete business for the day. The Workshop will reconvene on Wednesday, April 6..., Newport Research Station--Bldg. 955, 2032 S.E. OSU Drive, Newport, OR 97365-5275; telephone: (541) 867...

African Journal of Biomedical Research - Vol 21, No 1 (2018)

African Journals Online (AJOL)

Onchocercal DNA amplification using beta actin gene primers compared with first internal transcribed spacer sequences for monitoring onchocerciasis eradication strategy · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. H.O. Osue, H.I. Inabo, S.E. Yakubu, P.A. Audu, ...

Increased risk of depression in patients with cutaneous lupus erythematosus and systemic lupus erythematosus

DEFF Research Database (Denmark)

Hesselvig, J H; Egeberg, A; Kofoed, K

2018-01-01

BACKGROUND: Reported prevalences of depression in patients with systemic lupus erythematosus (SLE) range widely, while the prevalence of depression in cutaneous lupus erythematosus (CLE) remains severely understudied. OBJECTIVES: To examine whether patients with SLE or CLE have increased risk...... of primary and secondary care, analyses of risk for depression and antidepressant use were performed in Cox regression models adjusted for age, sex, socio-economic status, smoking, alcohol abuse, prior depression, and prior antidepressant use. RESULTS: A total of 3,489 patients with lupus erythematosus were...

Individual differences in memory span: relationship between rate of ...

African Journals Online (AJOL)

Individual differences in memory span: relationship between rate of item identification and rate of reading. AM Sunmola, CC Ukachi, JI Osu. Abstract. No Abstract Available African Journal for the Psychological Study of Social Issues Vol.4(1) 1999: 74-78. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL ...

Library Information Made to Order: An Open Source Project Built for and with Librarians

Science.gov (United States)

Griggs, Kim

2009-01-01

Oregon State University (OSU) libraries, where the author serves as lead programmer, have developed a tool to make it easier for librarians to build and maintain interactive course assignment pages (ICAPs) and subject research guides (SRGs). That tool, Library a la Carte, enables librarians with minimal technical expertise to create dynamic…

Building a Champagne Network on a Beer Budget

Science.gov (United States)

Dolan, Jon; Pederson, Curt

2004-01-01

Oregon State University's demand for bandwidth to support scientific collaboration and research continues to grow exponentially, while state funding declines due to hard economic times. The challenge faced by these authors was to find creative yet fiscally responsible ways to meet OSU's bandwidth demands. Looking at their options for high-capacity…

Hypotrochoids in conformal restriction systems and Virasoro descendants

International Nuclear Information System (INIS)

Doyon, Benjamin

2013-01-01

A conformal restriction system is a commutative, associative, unital algebra equipped with a representation of the groupoid of univalent conformal maps on connected open sets of the Riemann sphere, along with a family of linear functionals on subalgebras, satisfying a set of properties including conformal invariance and a type of restriction. This embodies some expected properties of expectation values in conformal loop ensembles CLE κ (at least for 8/3 iθ and w. We find that it has an expansion in positive powers of u and u-bar , and that the coefficients of pure u ( u-bar ) powers are holomorphic in w ( w-bar ). We identify these coefficients (the ‘hypotrochoid fields’) with certain Virasoro descendants of the identity field in conformal field theory, thereby showing that they form part of a vertex operator algebraic structure. This largely generalizes works by the author (in CLE), and the author with his collaborators Riva and Cardy (in SLE 8/3 and other restriction measures), where the case of the ellipse, at the order u 2 , led to the stress–energy tensor of CFT. The derivation uses in an essential way the Virasoro vertex operator algebra structure of conformal derivatives established recently by the author. The results suggest in particular the exact evaluation of CLE expectations of products of hypotrochoid fields as well as nontrivial relations amongst them through the vertex operator algebra, and further shed light onto the relationship between CLE and CFT. (paper)

Eglise - société - Etat L’Église orthodoxe serbe à la fin du XXe et au début du XXIe siècle

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Bojović Boško

2010-01-01

Full Text Available Au cours du dernier tiers du XXe siècle les institutions religieuses ont parcouru subrepticement le chemin entre marginalisation et passage au premier plan de la scène publique des pays en transition. La fin des idéologies s’est soldée par la mise en place des identités communautaristes. Alors que dans les démocraties libérales le fait religieux est caractérisé par la formule believing without belonging, les choses sont diamétralement opposées dans les sociétés en transition. Minoritaire avant la fin des années quatre-vingts, l’appartenance confessionnelle atteint ainsi 94% lors du recensement de 2003 en Serbie-Monténegro. L’appartenance à la confession majoritaire se situe autour de 50% d’une population dans un pays comme la France, le point commun avec la Serbie étant que quelques 4% seulement se déclarent pratiquants. La spécificité des pays en transition tardive comme la Serbie, où le catéchisme a été introduit en 2000, dix ans après la Croatie et la Bosnie-Herzégovine, soulève la question de la cléricalisation rapide de la société en contrepartie de la sécularisation et de la politisation des communautés confessionnelles. À défaut d’un projet de société, en moins de temps que dans les autres pays en transition, les institutions religieuses se sont mues en supports idéologiques des autorités politiques affaiblies, en génératrices des restructurations des identités ethno-confessionnelles, en piliers des cohésions communautaires, en institutions pilotes de consensus sociaux. Cela explique qu’une analyse de ce processus d’histoire de société n’est pas seulement à même de nous éclairer sur notre passé le plus récent, mais encore sur le devenir du présent qui est le nôtre à l’horizon de nouveaux élargissements européens.

Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells.

Science.gov (United States)

Noolu, Bindu; Ajumeera, Rajanna; Chauhan, Anitha; Nagalla, Balakrishna; Manchala, Raghunath; Ismail, Ayesha

2013-01-09

Inhibition of the proteolytic activity of 26S proteasome, the protein-degrading machine, is now considered a novel and promising approach for cancer therapy. Interestingly, proteasome inhibitors have been demonstrated to selectively kill cancer cells and also enhance the sensitivity of tumor cells to chemotherapeutic agents. Recently, polyphenols/flavonoids have been reported to inhibit proteasome activity. Murraya koenigii Spreng, a medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic system of medicine. Here we show that Murraya koenigii leaves (curry leaves), a rich source of polyphenols, inhibit the proteolytic activity of the cancer cell proteasome, and cause cell death. Hydro-methanolic extract of curry leaves (CLE) was prepared and its total phenolic content [TPC] determined by, the Folin-Ciocalteau's method. Two human breast carcinoma cell lines: MCF-7 and MDA-MB-231 and a normal human lung fibroblast cell line, WI-38 were used for the studies. Cytotoxicity of the CLE was assessed by the MTT assay. We studied the effect of CLE on growth kinetics using colony formation assay. Growth arrest was assessed by cell cycle analysis and apoptosis by Annexin-V binding using flow cytometry. Inhibition of the endogenous 26S proteasome was studied in intact cells and cell extracts using substrates specific to 20S proteasomal enzymes. CLE decreased cell viability and altered the growth kinetics in both the breast cancer cell lines in a dose-dependent manner. It showed a significant arrest of cells in the S phase albeit in cancer cells only. Annexin V binding data suggests that cell death was via the apoptotic pathway in both the cancer cell lines. CLE treatment significantly decreased the activity of the 26S proteasome in the cancer but not normal cells. Our study suggests M. koenigii leaves to be a potent source of proteasome inhibitors that lead to cancer cell death. Therefore, identification of active component(s) from the leaf

Joseph V. Denney, the Land-Grant Mission, and Rhetorical Education at Ohio State: An Institutional History

Science.gov (United States)

Mendenhall, Annie S.

2011-01-01

This essay provides an account of The Ohio State University's (OSU) rhetoric department during the tenure of Joseph Villiers Denney, arguing that he appropriated and repurposed national trends in education and rhetoric in ways that complicate the narrative of rhetoric and composition's decline in the late nineteenth century. In this essay, the…

Stigmatisation et identification des pratiques homosexuelles masculines à travers des membres des classes populaires parisiennes au cours de la première partie du xixe siècle

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Thierry Pastorello

2011-04-01

Full Text Available Au cours de la première partie du xixe siècle, l’homosexualité masculine est stigmatisée au travers de la figure du pédéraste. Il devient une figure emblématique du désordre, liée à divers fléaux sociaux. Les médecins légistes construisent un personnage personnifiant la transgression d’un ordre sexuel. Cependant, ces discours ont-ils un impact réel sur certains hommes issus des classes populaires urbaines ? On distingue parfaitement deux types d’hommes dans certains fichiers de police. Certains hommes « efféminés » sont affublés du qualificatif de tante. D’autres ne sont pas affublés de ce qualificatif et correspondraient à ceux que Georges Chauncey nomme Trades : ils répondent aux sollicitations des tantes. De plus, certaines libertés d’attitudes, de même que le développement de la prostitution masculine pourraient démontrer le poids limité des discours stigmatisants.Stigmatisation of the male homosexual pratictes and the identifications through limbed of the parisian popular classes during the first part of the XIXth centuryDuring the first part of the xixth century, the male homosexuality is stigmatized through the figure of the pederast. He becomes a symbolic face of the disorder, related to diverse social plagues. The forensic scientists build a character personifying the malpractice of a sexual order. However, these speeches have a real impact on certain men stemming from urban lower classes? We distinguish perfectly two types of men in certain files of police. Certain feminine are decked out by aunt's qualifier. Others are not decked out by this qualifier and would correspond to those whom Georges Chauncey names Trades: they answer to the requests of the aunts. Furthermore, certain liberties of attitudes, as well as the development of the male prostitution could demonstrate the weight limited by the stigmatizing speeches.

Du caractère sociable de l’intime : le plaisir esthétique chez Kant, entre solitude et communication

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Raphaël Ehrsam

2016-11-01

Full Text Available Dans une large mesure, du XVIIe au XVIIIe siècle, on assiste à une métamorphose théorique des rapports entre plaisir, solitude et sociabilité. Tandis qu’au XVIIe siècle (et encore chez plusieurs auteurs du XVIIIe, le plaisir est décrit comme une expérience dont le lieu principal est la sociabilité, à l’inverse de la méditation sise de préférence dans la solitude, le XVIIIe siècle réinscrit le plaisir dans l’intimité solitaire du moi et majore l’idée d’une nécessaire communauté des sujets connaissant. La caractérisation kantienne de l’expérience esthétique, comme expérience d’un plaisir qui enveloppe immédiatement une prétention à l’universalité et à la communication, apparaît dès lors comme une façon de rompre la logique de ce chiasme.

Developing and fostering a dynamic program for training in veterinary pathology and clinical pathology: veterinary students to post-graduate education.

Science.gov (United States)

Lairmore, Michael D; Oglesbee, Michael; Weisbrode, Steve E; Wellman, Maxey; Rosol, Thomas; Stromberg, Paul

2007-01-01

Recent reports project a deficiency of veterinary pathologists, indicating a need to train highly qualified veterinary pathologists, particularly in academic veterinary medicine. The need to provide high-quality research training for veterinary pathologists has been recognized by the veterinary pathology training program of the Ohio State University (OSU) since its inception. The OSU program incorporates elements of both residency training and graduate education into a unified program. This review illustrates the components and structure of the training program and reflects on future challenges in training veterinary pathologists. Key elements of the OSU program include an experienced faculty, dedicated staff, and high-quality students who have a sense of common mission. The program is supported through cultural and infrastructure support. Financial compensation, limited research funding, and attractive work environments, including work-life balance, will undoubtedly continue to be forces in the marketplace for veterinary pathologists. To remain competitive and to expand the ability to train veterinary pathologists with research skills, programs must support strong faculty members, provide appropriate infrastructure support, and seek active partnerships with private industry to expand program opportunities. Shortages of trained faculty may be partially resolved by regional cooperation to share faculty expertise or through the use of communications technology to bridge distances between programs. To foster continued interest in academic careers, training programs will need to continue to evolve and respond to trainees' needs while maintaining strong allegiances to high-quality pathology training. Work-life balance, collegial environments that foster a culture of respect for veterinary pathology, and continued efforts to reach out to veterinary students to provide opportunities to learn about the diverse careers offered in veterinary pathology will pay long

Dietary supply of selenium for adolescents in three residential care orphanages in Southern Ghana

International Nuclear Information System (INIS)

Adotey, Dennis K.; Stibilj, Vekoslava; Serfor-Armah, Yaw; Nyarko, Benjamin J.B.; Jaćimović, Radojko

2011-01-01

Adolescents require optimum dietary supply of the essential trace mineral selenium (Se); however the absence of reliable and accurate data on the dietary supply of selenium for the adolescent population in Ghanaian residential care orphanages have made it difficult for public health nutritionists to assess the adequacy of the dietary supply. The dietary supply of selenium for adolescents (12–15 years) in three residential care orphanages, (Osu, Tutu-Akwapim and Teshie), in Southern Ghana have been evaluated by sampling their 24-h duplicate diets (including water) for 7-consecutive days using the duplicate diet sampling technique. The mass fraction of selenium in the blended lyophilized homogenates of duplicate diets was determined by radiochemical neutron activation analysis (RNAA). The validity of the RNAA method for selenium determination was checked by analyses of NIST SRM 1548a (Typical diet). The chemical yield of the radiochemical separation was determined by spectrophotometry. The average mass fractions of selenium in the blended lyophilized 24-hour duplicate diets for Osu, Tutu-Akwapim and Teshie were; 165 ± 61 [117.2–285.2], 203 ± 68 [110.5–304.9] and 250 ± 92 [128.8–408.0] ng Se g −1 lyophilized matter respectively. The average dietary supply of Se were, 57.6 ± 17.3 [42.2–88.4], 82.0 ± 30.7 [44.3–136.2] and 91.7 ± 44.2 [46.0–153.4] μg Se day −1 for Osu, Tutu-Akwapim and Teshie orphanages respectively. The data generated will help public health nutritionists in the provision of dietary advice and nutritional support for the studied orphanages, as well as other orphanages. The data will also help in the planning of institutional diets.

The Use of Institutional Repositories: The Ohio State University Experience

Science.gov (United States)

Connell, Tschera Harkness

2011-01-01

In this paper the author compares the use of digital materials that have been deposited in The Ohio State University (OSU) Knowledge Bank (KB). Comparisons are made for content considered in scope of the university archives and those considered out of scope, for materials originating from different campus sources, and for different types of…

Use of Maple Seeding Canopy Reflectance Dataset for Validation of SART/LEAFMOD Radiative Transfer Model

Science.gov (United States)

Bond, Barbara J.; Peterson, David L.

1999-01-01

This project was a collaborative effort by researchers at ARC, OSU and the University of Arizona. The goal was to use a dataset obtained from a previous study to "empirically validate a new canopy radiative-transfer model (SART) which incorporates a recently-developed leaf-level model (LEAFMOD)". The document includes a short research summary.

Microsatellite analysis of the correlation between molecular and ...

African Journals Online (AJOL)

The Co-ancestry distance showed six tied groups with the Kenya cluster showing some differentiation with Exact Tests for population differentiation with a p = 0.0513. The American inbred line (OSU 23i) segregated alone, while the Kenya lines (EM11-133 and. EM12-210) had close homology with the CIMMYT inbred lines ...

Bureau of Land Management density management study.

Science.gov (United States)

John Cissel; Paul Anderson; Shanti Berryman; Sam Chan; Deanna Olson; Klaus. Puettman

2004-01-01

The Bureau of Land Management (BLM), Pacific Northwest Research Station (PNW), U.S. Geological Survey (USGS), and Oregon State University (OSU) established the Density Management Study (DMS) in 1994 to develop and test options for young stand management to meet Northwest Forest Plan objectives in western Oregon. The DMS demonstrates and evaluates alternative approaches...

Theoretical studies in nuclear physics. Three year progress report and final report

International Nuclear Information System (INIS)

Landau, R.H.; Madsen, V.A.

1996-01-01

In 1995 the DOE grant in Nuclear theory with Professors Rubin H. Landau and Victor A. Madsen as co-principal investigators ended. Their research was carried out in collaboration with graduate students in Corvallis, and with scientists at LLNL-Livermore, Los Alamos, TRIUMF, KFA-Julich, Hamburg University, Melbourne University, The Thinking Machine Corporation and IBM Research. Activities in nuclear and particle physics at Oregon State University (OSU) were diverse and active. Madsen's work concentrated on the relation of reactions to the nuclear structure, and Landau's work concentrated on intermediate energy physics, few-body problems, and computational physics. The Landau group had a weekly meeting of students and visitors. There was a weekly nuclear seminar with experimental and theoretical colleagues, and a weekly departmental colloquium. The DOE support had permitted the group to run Unix workstations networked to other computers in the Physics Department and the University. Since 1990 OSU has been using IBM RISC System 6000/model 530 with console and four X-stations. The equipment was purchased and is maintained with yearly DOE funding of the group

Information on the Advanced Plant Experiment (APEX) Test Facility

International Nuclear Information System (INIS)

Smith, Curtis Lee

2015-01-01

The purpose of this report provides information related to the design of the Oregon State University Advanced Plant Experiment (APEX) test facility. Information provided in this report have been pulled from the following information sources: Reference 1: R. Nourgaliev and et.al, 'Summary Report on NGSAC (Next-Generation Safety Analysis Code) Development and Testing,' Idaho National Laboratory, 2011. Note that this is report has not been released as an external report. Reference 2: O. Stevens, Characterization of the Advanced Plant Experiment (APEX) Passive Residual Heat Removal System Heat Exchanger, Master Thesis, June 1996. Reference 3: J. Reyes, Jr., Q. Wu, and J. King, Jr., Scaling Assessment for the Design of the OSU APEX-1000 Test Facility, OSU-APEX-03001 (Rev. 0), May 2003. Reference 4: J. Reyes et al, Final Report of the NRC AP600 Research Conducted at Oregon State University, NUREG/CR-6641, July 1999. Reference 5: K. Welter et al, APEX-1000 Confirmatory Testing to Support AP1000 Design Certification (non-proprietary), NUREG-1826, August 2005.

A NEW NETWORK FOR HIGHER-TEMPERATURE GAS-PHASE CHEMISTRY. I. A PRELIMINARY STUDY OF ACCRETION DISKS IN ACTIVE GALACTIC NUCLEI

International Nuclear Information System (INIS)

Harada, Nanase; Herbst, Eric; Wakelam, Valentine

2010-01-01

We present a new interstellar chemical gas-phase reaction network for time-dependent kinetics that can be used for modeling high-temperature sources up to ∼800 K. This network contains an extended set of reactions based on the Ohio State University (OSU) gas-phase chemical network. The additional reactions include processes with significant activation energies, reverse reactions, proton exchange reactions, charge exchange reactions, and collisional dissociation. Rate coefficients already in the OSU network are modified for H 2 formation on grains, ion-neutral dipole reactions, and some radiative association reactions. The abundance of H 2 O is enhanced at high temperature by hydrogenation of atomic O. Much of the elemental oxygen is in the form of water at T ≥ 300 K, leading to effective carbon-rich conditions, which can efficiently produce carbon-chain species such as C 2 H 2 . At higher temperatures, HCN and NH 3 are also produced much more efficiently. We have applied the extended network to a simplified model of the accretion disk of an active galactic nucleus.

Direct Drive Wave Energy Buoy – 33rd scale experiment

Energy Technology Data Exchange (ETDEWEB)

Rhinefrank, Kenneth E. [Columbia Power Technologies, Inc.; Lenee-Bluhm, Pukha [Columbia Power Technologies, Inc.; Prudell, Joseph H. [Columbia Power Technologies, Inc.; Schacher, Alphonse A.; Hammagren, Erik J.; Zhang, Zhe [Columbia Power Technologies, Inc.

2013-07-29

Columbia Power Technologies (ColPwr) and Oregon State University (OSU) jointly conducted a series of tests in the Tsunami Wave Basin (TWB) at the O.H. Hinsdale Wave Research Laboratory (HWRL). These tests were run between November 2010 and February 2011. Models at 33rd scale representing Columbia Power’s Manta series Wave Energy Converter (WEC) were moored in configurations of one, three and five WEC arrays, with both regular waves and irregular seas generated. The primary research interest of ColPwr is the characterization of WEC response. The WEC response will be investigated with respect to power performance, range of motion and generator torque/speed statistics. The experimental results will be used to validate a numerical model. The primary research interests of OSU include an investigation into the effects of the WEC arrays on the near- and far-field wave propagation. This report focuses on the characterization of the response of a single WEC in isolation. To facilitate understanding of the commercial scale WEC, results will be presented as full scale equivalents.

A quality-of-life study of cutaneous lupus erythematosus.

Science.gov (United States)

Batalla, A; García-Doval, I; Peón, G; de la Torre, C

2013-11-01

The study of quality of life in patients with skin disorders has become more important in recent decades. In the case of lupus erythematosus, most quality-of-life studies have focused on the systemic form of the disease, with less attention being paid to the cutaneous form. The main objective of this study was to evaluate quality of life in patients with cutaneous lupus erythematosus (CLE) using a dermatology-specific questionnaire: the Dermatology Life Quality Index (DLQI). Our secondary objective was to investigate associations between DLQI scores and other aspects of the disease. Thirty-six patients with CLE completed the DLQI questionnaire. Other factors assessed were disease severity (measured using the Cutaneous Lupus Erythematosus Disease Area and Severity Index), time since diagnosis, body surface area affected, previous and current treatments, and the presence of criteria for systemic lupus erythematosus (SLE). According to the DLQI, CLE had a moderate, very large, or extremely large effect on quality of life in 50% of the patients analyzed (18/36). No significant associations were found between DLQI scores and disease severity, time since diagnosis, body surface area affected, number, type, or duration of pharmacologic treatments, or the presence or absence of SLE criteria. CLE has a significant and lasting effect on patient quality of life. This effect is probably primarily due to multiple factors, including the chronic nature of the disease, the visibility of the lesions, and the fact that they can cause disfigurement. Copyright © 2012 Elsevier España, S.L. and AEDV. All rights reserved.

Multicolor probe-based confocal laser endomicroscopy: a new world for in vivo and real-time cellular imaging

Science.gov (United States)

Vercauteren, Tom; Doussoux, François; Cazaux, Matthieu; Schmid, Guillaume; Linard, Nicolas; Durin, Marie-Amélie; Gharbi, Hédi; Lacombe, François

2013-03-01

Since its inception in the field of in vivo imaging, endomicroscopy through optical fiber bundles, or probe-based Confocal Laser Endomicroscopy (pCLE), has extensively proven the benefit of in situ and real-time examination of living tissues at the microscopic scale. By continuously increasing image quality, reducing invasiveness and improving system ergonomics, Mauna Kea Technologies has turned pCLE not only into an irreplaceable research instrument for small animal imaging, but also into an accurate clinical decision making tool with applications as diverse as gastrointestinal endoscopy, pulmonology and urology. The current implementation of pCLE relies on a single fluorescence spectral band making different sources of in vivo information challenging to distinguish. Extending the pCLE approach to multi-color endomicroscopy therefore appears as a natural plan. Coupling simultaneous multi-laser excitation with minimally invasive, microscopic resolution, thin and flexible optics, allows the fusion of complementary and valuable biological information, thus paving the way to a combination of morphological and functional imaging. This paper will detail the architecture of a new system, Cellvizio Dual Band, capable of video rate in vivo and in situ multi-spectral fluorescence imaging with a microscopic resolution. In its standard configuration, the system simultaneously operates at 488 and 660 nm, where it automatically performs the necessary spectral, photometric and geometric calibrations to provide unambiguously co-registered images in real-time. The main hardware and software features, including calibration procedures and sub-micron registration algorithms, will be presented as well as a panorama of its current applications, illustrated with recent results in the field of pre-clinical imaging.

‘Michel de Certeau. Le marcheur blessé’.

Directory of Open Access Journals (Sweden)

François Dosse

2002-09-01

Full Text Available Quatrième de couverture. Jésuite et historien spécialiste du 17 e siècle et de la mystique, sociologue de la culture du quotidien, anthropologue, sémiologue et cofondateur de l'école lacanienne, Michel de Certeau est une figure singulière de l'histoire intellectuelle du 20 e siècle. Célébré par le tout-Paris lors de sa disparition en janvier 1986, il fut toute sa vie un franc-tireur. Position qui n'a sans doute pas permis de mesurer son apport au renouvellement des ...

Role of Confocal Laser Endomicroscopy in Detection of Residual Barrett's Esophagus after Radiofrequency Ablation

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Giorgio Diamantis

2011-01-01

Full Text Available Endoscopic endoluminal radiofrequency ablation (RFA is a novel and promising modality for Barrett's esophagus (BE treatment. Actually the only surveillance method after the ablation treatment is random biopsies throughout the whole treated area. Confocal laser endomicroscopy (CLE is a new endoscopic imaging tool that permits high-resolution microscopic examination of the gastrointestinal tract. The technology has garnered increasing attention because of its ability to provide real-time “optical” biopsy specimens, with a very high sensitivity and specificity. This paper summarize the potential application of CLE in the surveillance of the reepithelialization of BE, after endoscopic RFA.

Une folle débauche. Les prostituées à la Salpêtrière et dans le discours médical (1850-1914.

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Thiphaine Besnard

2010-07-01

Full Text Available La prostitution de rue occupe une place importante dans les questionnements moraux et politiques de la société parisienne, au XIXe comme au XXe siècle. L'importance de cette thématique se mesure au nombre impressionnant de publications qui ont pour sujet le commerce sexuel. Cette thématique médicale prend un sens particulièrement intéressant dans le contexte intellectuel propre au second XIXe siècle, en l'occurrence, celui d'une vaste entreprise de classification des êtres humains en catégori...

Le droit et la régulation des pouvoirs dans l’économie-monde

OpenAIRE

Chanteau, Jean-Pierre

2018-01-01

Introduction Il y a presque un demi-siècle se constituait l’économie politique internationale (EPI) (Keohane & Nye [eds], 1971) dont l’objet se définit classiquement comme l’étude des rapports entre la puissance politique et la richesse économique. La date n’est pas fortuite : si la transnationalisation des entreprises apparaît dès la fin du xixe siècle, elle prend une ampleur inédite dans cette décennie 1970 et pose un nouveau problème à l’économie internationale. Le questionnement de l’EPI ...

Education and research at the Ohio State University nuclear reactor laboratory

International Nuclear Information System (INIS)

Miller, D.W.; Myser, R.D.; Talnagi, J.W.

1989-01-01

The educational and research activities at the Ohio State University Nuclear Reactor Laboratory (OSUNRL) are discussed in this paper. A brief description of an OSUNRL facility improvement program and its expected impact on research is presented. The overall long-term goal of the OSUNRL is to support the comprehensive education, research, and service mission of OSU

Genome Enabled Discovery of Carbon Sequestration Genes in Poplar

Energy Technology Data Exchange (ETDEWEB)

Filichkin, Sergei; Etherington, Elizabeth; Ma, Caiping; Strauss, Steve

2007-02-22

The goals of the S.H. Strauss laboratory portion of 'Genome-enabled discovery of carbon sequestration genes in poplar' are (1) to explore the functions of candidate genes using Populus transformation by inserting genes provided by Oakridge National Laboratory (ORNL) and the University of Florida (UF) into poplar; (2) to expand the poplar transformation toolkit by developing transformation methods for important genotypes; and (3) to allow induced expression, and efficient gene suppression, in roots and other tissues. As part of the transformation improvement effort, OSU developed transformation protocols for Populus trichocarpa 'Nisqually-1' clone and an early flowering P. alba clone, 6K10. Complete descriptions of the transformation systems were published (Ma et. al. 2004, Meilan et. al 2004). Twenty-one 'Nisqually-1' and 622 6K10 transgenic plants were generated. To identify root predominant promoters, a set of three promoters were tested for their tissue-specific expression patterns in poplar and in Arabidopsis as a model system. A novel gene, ET304, was identified by analyzing a collection of poplar enhancer trap lines generated at OSU (Filichkin et. al 2006a, 2006b). Other promoters include the pGgMT1 root-predominant promoter from Casuarina glauca and the pAtPIN2 promoter from Arabidopsis root specific PIN2 gene. OSU tested two induction systems, alcohol- and estrogen-inducible, in multiple poplar transgenics. Ethanol proved to be the more efficient when tested in tissue culture and greenhouse conditions. Two estrogen-inducible systems were evaluated in transgenic Populus, neither of which functioned reliably in tissue culture conditions. GATEWAY-compatible plant binary vectors were designed to compare the silencing efficiency of homologous (direct) RNAi vs. heterologous (transitive) RNAi inverted repeats. A set of genes was targeted for post transcriptional silencing in the model Arabidopsis system; these include the floral

OSU TOMF Program Site Selection and Preliminary Concept Design Report

Energy Technology Data Exchange (ETDEWEB)

Spadling, Steve [Oklahoma State Univ., Stillwater, OK (United States)

2012-05-10

The purpose of this report is to confirm the programmatic requirements for the new facilities, identify the most appropriate project site, and develop preliminary site and building concepts that successfully address the overall project goals and site issues. These new facilities will be designed to accommodate the staff, drivers and maintenance requirements for the future mixed fleet of passenger vehicles, Transit Style Buses and School Buses.

Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells

Directory of Open Access Journals (Sweden)

Noolu Bindu

2013-01-01

Full Text Available Abstract Background Inhibition of the proteolytic activity of 26S proteasome, the protein-degrading machine, is now considered a novel and promising approach for cancer therapy. Interestingly, proteasome inhibitors have been demonstrated to selectively kill cancer cells and also enhance the sensitivity of tumor cells to chemotherapeutic agents. Recently, polyphenols/flavonoids have been reported to inhibit proteasome activity. Murraya koenigii Spreng, a medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic system of medicine. Here we show that Murraya koenigii leaves (curry leaves, a rich source of polyphenols, inhibit the proteolytic activity of the cancer cell proteasome, and cause cell death. Methods Hydro-methanolic extract of curry leaves (CLE was prepared and its total phenolic content [TPC] determined by, the Folin-Ciocalteau’s method. Two human breast carcinoma cell lines: MCF-7 and MDA-MB-231 and a normal human lung fibroblast cell line, WI-38 were used for the studies. Cytotoxicity of the CLE was assessed by the MTT assay. We studied the effect of CLE on growth kinetics using colony formation assay. Growth arrest was assessed by cell cycle analysis and apoptosis by Annexin-V binding using flow cytometry. Inhibition of the endogenous 26S proteasome was studied in intact cells and cell extracts using substrates specific to 20S proteasomal enzymes. Results CLE decreased cell viability and altered the growth kinetics in both the breast cancer cell lines in a dose-dependent manner. It showed a significant arrest of cells in the S phase albeit in cancer cells only. Annexin V binding data suggests that cell death was via the apoptotic pathway in both the cancer cell lines. CLE treatment significantly decreased the activity of the 26S proteasome in the cancer but not normal cells. Conclusions Our study suggests M. koenigii leaves to be a potent source of proteasome inhibitors that lead to cancer cell death

Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma.

Directory of Open Access Journals (Sweden)

Daniela Ştefănescu

Full Text Available Confocal laser endomicroscopy (CLE is becoming a popular method for optical biopsy of digestive mucosa for both diagnostic and therapeutic procedures. Computer aided diagnosis of CLE images, using image processing and fractal analysis can be used to quantify the histological structures in the CLE generated images. The aim of this study is to develop an automatic diagnosis algorithm of colorectal cancer (CRC, based on fractal analysis and neural network modeling of the CLE-generated colon mucosa images.We retrospectively analyzed a series of 1035 artifact-free endomicroscopy images, obtained during CLE examinations from normal mucosa (356 images and tumor regions (679 images. The images were processed using a computer aided diagnosis (CAD medical imaging system in order to obtain an automatic diagnosis. The CAD application includes image reading and processing functions, a module for fractal analysis, grey-level co-occurrence matrix (GLCM computation module, and a feature identification module based on the Marching Squares and linear interpolation methods. A two-layer neural network was trained to automatically interpret the imaging data and diagnose the pathological samples based on the fractal dimension and the characteristic features of the biological tissues.Normal colon mucosa is characterized by regular polyhedral crypt structures whereas malignant colon mucosa is characterized by irregular and interrupted crypts, which can be diagnosed by CAD. For this purpose, seven geometric parameters were defined for each image: fractal dimension, lacunarity, contrast correlation, energy, homogeneity, and feature number. Of the seven parameters only contrast, homogeneity and feature number were significantly different between normal and cancer samples. Next, a two-layer feed forward neural network was used to train and automatically diagnose the malignant samples, based on the seven parameters tested. The neural network operations were cross

Confocal laser endomicroscopy for diagnosis and histomorphologic imaging of brain tumors in vivo.

Directory of Open Access Journals (Sweden)

Sebastian Foersch

Full Text Available Early detection and evaluation of brain tumors during surgery is crucial for accurate resection. Currently cryosections during surgery are regularly performed. Confocal laser endomicroscopy (CLE is a novel technique permitting in vivo histologic imaging with miniaturized endoscopic probes at excellent resolution. Aim of the current study was to evaluate CLE for in vivo diagnosis in different types and models of intracranial neoplasia. In vivo histomorphology of healthy brains and two different C6 glioma cell line allografts was evaluated in rats. One cell line expressed EYFP, the other cell line was used for staining with fluorescent dyes (fluorescein, acriflavine, FITC-dextran and Indocyanine green. To evaluate future application in patients, fresh surgical resection specimen of human intracranial tumors (n = 15 were examined (glioblastoma multiforme, meningioma, craniopharyngioma, acoustic neurinoma, brain metastasis, medulloblastoma, epidermoid tumor. Healthy brain tissue adjacent to the samples served as control. CLE yielded high-quality histomorphology of normal brain tissue and tumors. Different fluorescent agents revealed distinct aspects of tissue and cell structure (nuclear pattern, axonal pathways, hemorrhages. CLE discrimination of neoplastic from healthy brain tissue was easy to perform based on tissue and cellular architecture and resemblance with histopathology was excellent. Confocal laser endomicroscopy allows immediate in vivo imaging of normal and neoplastic brain tissue at high resolution. The technology might be transferred to scientific and clinical application in neurosurgery and neuropathology. It may become helpful to screen for tumor free margins and to improve the surgical resection of malignant brain tumors, and opens the door to in vivo molecular imaging of tumors and other neurologic disorders.

De Profundis d’Oscar Wilde: la quête d’identité du dandy en prison

Directory of Open Access Journals (Sweden)

2010-02-01

Full Text Available Plus d’un siècle après sa mort, Oscar Wilde continue de susciter l’intérêt tant pour son œuvre que pour sa vie. Dandy toute sa vie, d’une taille hors du commun, ce n’est pas seulement l’artiste mais aussi l’homme qui a marqué son siècle et continue d’enthousiasmer le lecteur du vingt-et-unième siècle. (... L’écriture de soi en souffrance, comme nous le voyons à travers De Profundis, aboutit à la preuve que son génie artistique est intact. (... L’écriture combat la souffrance de l’isolation et de la déchéance, mais dans le cas de Wilde, c’est également le moyen de se reconstruire en tant qu’homme et en tant qu’artiste: il n’a plus de nom, plus de reconnaissance par les hommes, mais le texte, que Wilde l’ai pensé ou non, est une nouvelle œuvre d’art qui montre la capacité et la force de l’esprit en condition d’oppression.

Inadvertent chest tube insertion in congenital cystic adenomatoid malformation and congenital lobar emphysema-highlighting an important problem

International Nuclear Information System (INIS)

Prabhu, Shailesh M; Choudhury, Subhasis Roy; Solanki, Ravi S; Shetty, Gurucharan S; Agarwala, Surenderkumar

2013-01-01

Chest tube insertion in congenital cystic lung lesions is an important problem in children with acute respiratory distress having a cystic lucent lesion on chest radiograph. To evaluate the imaging findings and complications in cases of congenital cystic lung lesions with chest tube insertion and suggest the role of appropriate imaging for management of these patients. Chest radiographs and CT scans of children with congenital cystic lung lesions who had inadvertent chest tube insertion preoperatively were retrospectively reviewed for imaging appearances and complications. Fifteen patients comprising 10 cases of congenital cystic adenomatoid malformation (CCAM) and 5 cases of congenital lobar emphysema (CLE) were included. Majority of the cases were infants. CCAM was misdiagnosed as complicated pneumatocele (n = 5) and pneumothorax (n = 5), while CLE was misdiagnosed as tension pneumothorax (n = 5) on the chest radiograph findings. Final diagnosis was made on CT and operative findings with histopathology. Complications noted were pneumothorax, hydropneumothorax, and infection in cases of CCAM, and change in imaging appearance and pneumothorax in cases of CLE. Chest tube insertion in congenital cystic lesions increases the rate of associated complications. Chest CT has a definite role in early diagnosis and deciding appropriate management in these cases

Pulmonary emphysema classification based on an improved texton learning model by sparse representation

Science.gov (United States)

Zhang, Min; Zhou, Xiangrong; Goshima, Satoshi; Chen, Huayue; Muramatsu, Chisako; Hara, Takeshi; Yokoyama, Ryujiro; Kanematsu, Masayuki; Fujita, Hiroshi

2013-03-01

In this paper, we present a texture classification method based on texton learned via sparse representation (SR) with new feature histogram maps in the classification of emphysema. First, an overcomplete dictionary of textons is learned via KSVD learning on every class image patches in the training dataset. In this stage, high-pass filter is introduced to exclude patches in smooth area to speed up the dictionary learning process. Second, 3D joint-SR coefficients and intensity histograms of the test images are used for characterizing regions of interest (ROIs) instead of conventional feature histograms constructed from SR coefficients of the test images over the dictionary. Classification is then performed using a classifier with distance as a histogram dissimilarity measure. Four hundreds and seventy annotated ROIs extracted from 14 test subjects, including 6 paraseptal emphysema (PSE) subjects, 5 centrilobular emphysema (CLE) subjects and 3 panlobular emphysema (PLE) subjects, are used to evaluate the effectiveness and robustness of the proposed method. The proposed method is tested on 167 PSE, 240 CLE and 63 PLE ROIs consisting of mild, moderate and severe pulmonary emphysema. The accuracy of the proposed system is around 74%, 88% and 89% for PSE, CLE and PLE, respectively.

Science Based Human Reliability Analysis: Using Digital Nuclear Power Plant Simulators for Human Reliability Research

Science.gov (United States)

Shirley, Rachel Elizabeth

Nuclear power plant (NPP) simulators are proliferating in academic research institutions and national laboratories in response to the availability of affordable, digital simulator platforms. Accompanying the new research facilities is a renewed interest in using data collected in NPP simulators for Human Reliability Analysis (HRA) research. An experiment conducted in The Ohio State University (OSU) NPP Simulator Facility develops data collection methods and analytical tools to improve use of simulator data in HRA. In the pilot experiment, student operators respond to design basis accidents in the OSU NPP Simulator Facility. Thirty-three undergraduate and graduate engineering students participated in the research. Following each accident scenario, student operators completed a survey about perceived simulator biases and watched a video of the scenario. During the video, they periodically recorded their perceived strength of significant Performance Shaping Factors (PSFs) such as Stress. This dissertation reviews three aspects of simulator-based research using the data collected in the OSU NPP Simulator Facility: First, a qualitative comparison of student operator performance to computer simulations of expected operator performance generated by the Information Decision Action Crew (IDAC) HRA method. Areas of comparison include procedure steps, timing of operator actions, and PSFs. Second, development of a quantitative model of the simulator bias introduced by the simulator environment. Two types of bias are defined: Environmental Bias and Motivational Bias. This research examines Motivational Bias--that is, the effect of the simulator environment on an operator's motivations, goals, and priorities. A bias causal map is introduced to model motivational bias interactions in the OSU experiment. Data collected in the OSU NPP Simulator Facility are analyzed using Structural Equation Modeling (SEM). Data include crew characteristics, operator surveys, and time to recognize

Chemical and Molecular Biological Aspects of Alkylhydrazine-Induced Carcinogenesis in Human Cells in Vitro. Revised

Science.gov (United States)

1984-04-01

DMH) and the metabolite methylazoxymethanol acetate ( MAMA ) have been shown to induce cancer in vivo in several species of rodents producing a variety of...The Pharmaceutical and Toxicological Research Institute (PTRI) I Co-Director, Developmental Chemotherapeutics, OSU Comprehensive Cancer Center...NNL[Methyl-l 4 C] I -dimethylhydrazine) of high specific activity Chapter III - Synthesis of (14 C] -labeled methylazoxymethanol 13 acetate ( MAMA ) of

Manipulating stand structure of Douglas-fir plantations for wildlife habitat and wood production

Science.gov (United States)

Timothy B. Harrington

2010-01-01

In southwestern Oregon, a study was initiated by Oregon State University (OSU) in 1983 to determine effects of hardwood competition on Douglas-fir plantation development. The use of herbicides to uniformly suppress competing vegetation—especially fast-growing hardwoods—proved to be an effective approach to ensure dominance and a high level of productivity for planted...

Le bovarysme, histoire et interprétation d’une pathologie littéraire à l’âge moderne

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Delphine Jayot

2009-02-01

Full Text Available Originellement hybride, la notion de bovarysme, inventée à la fin du XIXe siècle par Jules de Gaultier, a été conçue à partir d’un personnage littéraire pour décrire un phénomène de psychologie normale ou pathologique. Creuset d’interrogations pour deux champs de savoir distincts, la littérature et la psychopathologie, elle va connaître un double destin en devenant, au XXe siècle, une notion clé de la critique littéraire comme de la psychiatrie. Au croisement de diverses disciplines, cette no...

Information Communication Technology & Crime: the Future of Criminology

OpenAIRE

Antinori A.

2008-01-01

Jusqu’à présent, le XXIe siècle peut être considéré comme le siècle de la révolution technologique.L’augmentation des flux de communication a engendré une évolution de l’économie globale et de la diffusion globale d’Internet et de la téléphonie mobile dans lesquels nos vies sont plongées. Tout cela représente le principal facteur des mutations sociales.De nouveaux modèles de déviance et de criminalité voient le jour au sein du cyberspace, de même que les groupes terroristes traditionnels empl...

Crédit des illustrations

OpenAIRE

2017-01-01

Illustration de couverture : Lyon, cathédrale Saint-Jean, culée de l’arc-boutant 2/3 : David (XIIIe siècle) surgissant de l’échafaudage (XXIe siècle). Photo Jean-Pierre Gobillot. Illustration de la quatrième de couverture : Lyon, cathédrale Saint-Jean, arcature extérieure de l’abside, chapiteau central. Dessin Ghislaine Macabéo. Photos Jean-Pierre Gobillot : fig. 1, 2, 10, 13, 14, 16, 23, 28, 29, 34, 35, 36, 37, 40, 41, 46, 54, 55, 56, 59, 60, 67, 76a, 78, 80, 82, 83, 88, 90, 97, 105, 106, 11...

Comment représenter la transgression de genre - L'Hermaphrodite dans l'oeuvre de J. K. Huysmans -

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Mihaela Gabriela Stănică

2012-03-01

haunting the imaginary of the fin de siècle. Since the hermaphroditic body, this gender trouble that threatens the dual taxonomy of the society, is denied the ontological independence, this body enters the sphere of invisibility. Given that the transgressive body becomes a simple deviation, the hermaphrodite can only be a secondary representation. How are these mechanisms of the secondary representation applied to the literary productions of that period? The answer to this question could be found in Huysmans’ texts where the ambiguity of the hermaphroditic figure is captured into somatic and psychical representations that seem to confirm the epistemic paradigms of that fin de siècle.

Art et comportements symboliques au Paléolithique : quelques points de vue actuels

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Paillet, Patrick

2015-01-01

Du temps de la reconnaissance à l'archéologie des grottes ornées Édouard Lartet et Édouard Piette principalement ont marqué le XIX ème siècle par leurs extraordi-naires découvertes d'art mobilier et leurs efforts pour les faire reconnaître par la communauté scien-tifique alors placée sous l'autorité dogmatique de Gabriel de Mortillet et d'Émile Cartailhac. Ils ont aussi oeuvré, non sans mal, pour en faire admettre l'antiquité et l'authenticité. Une grande partie du XX ème siècle fut celle des...

Eclipsing Aestheticism: Western Landscape Photography After Ansel Adams

OpenAIRE

Dennis, Kelly

2015-01-01

Bien que l’héritage photographique d’Ansel Adams (1902-84) reste incontestable dans la culture de masse, dans les musées et parmi les collectionneurs, la nature de cet héritage fait débat parmi les artistes contemporains, les chercheurs et les théoriciens de la photographie. Pour certains, à la fin du 20ème siècle, les paysages typiques de Adams représentant l’Ouest américain au milieu du siècle désignaient une connivence secrète avec l’expansion américaine vers l’ouest durant la guerre froid...

Couleur de temps, fragments d’histoires, XIIe-XXe s. : peintures murales en Bourgogne et d’ailleurs

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Daniel Russo

2004-12-01

Full Text Available Avec la présentation de l’exposition sur les peintures murales en Bourgogne, depuis le XIIe siècle jusqu’aux dernières années du XXe siècle, il nous a paru nécessaire de faire le point sur les recherches actuellement menées. Loin des manifestations commémoratives et des réunions convenues sur des sujets attendus, nous avons regroupé et fait se rencontrer historiens de l’art, archéologues et historiens qui, tous, prennent en compte les observations directes effectuées sur les différents sites ...

Conflit foncier, reconfiguration territoriale et valeurs de la terre dans les montagnes de Cahabón (Guatemala)

OpenAIRE

Bergeret, Agnès

2016-01-01

Les montagnes tropicales de Cahabón (municipe du nord-est du Guatemala) ont connu en un demi-siècle une transformation radicale de leur configuration foncière et agricole. Les récits des acteurs locaux conduisent à étudier un conflit pour la terre très violent, dont les racines sont à chercher dans le dispositif du colonage construit à partir de la fin du XIXe siècle. Ils apportent des éléments complémentaires à la compréhension de la guerre interne guatémaltèque (1960-1996), souvent lue au t...

Louise Edwards, Gender, Politics, and Democracy: Women’s Suffrage in China

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Dirlik, Arif

2009-01-01

Gender, Politics, and Democracy retrace les luttes des femmes chinoises pour obtenir le droit de vote, depuis le tournant du XXe siècle jusqu’à la veille de la victoire des communistes en 1949. Edwards soutient que le terme « canzheng », suggérant la participation politique en général, était compris par les femmes activistes politiques de la première moitié du XXe siècle dans le sens plus concret de « participation au vote», « centré sur le double droit de voter et de se présenter aux électio...

Présentation

OpenAIRE

Brangé, Mireille; Nachtergael, Magali

2015-01-01

Le champ de la littérature et plus généralement du fait littéraire questionne sans cesse ses propres limites, obligeant à considérer toujours plus largement les textes relevant potentiellement de l’analyse littéraire. Les interactions entre les nombreux récits du quotidien, faits divers ou intimes, et la fabrique du texte littéraire sont elles-mêmes soumises à des fluctuations plus ou moins intenses : après le roman réaliste au xixe siècle ou l’autofiction à la fin du xxe siècle, la littératu...

Travail, immigration et relations sociales à travers les parcours d’individus et familles d’une ville de l’Ancien Régime (Turin, xviiie siècle

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Beatrice Zucca Micheletto

2009-10-01

Full Text Available Cet article envisage une utilisation des archives judiciaires qui, loin de refaire l’histoire sociale de la criminalité, a pour but d’interroger le système des normes et valeurs qui affectent les trajectoires professionnelles d’individus et familles qui fréquentent ou habitent la ville de Turin au xviiie siècle. Dans l’histoire des métiers artisanaux, abordés par l’unique biais des sources produites par les corporations elles-mêmes, la continuité et la stabilité du travail constituent le véritable fil rouge des démonstrations. Cela laisse dans l’ombre plusieurs phénomènes et notamment tout ce qui a trait aux trajectoires des individus dans l’espace urbain, ou ce qui concerne le temps et les modalités d’exercice d’un métier, le rôle du cycle de vie individuel et familial.À ce propos, les archives judiciaires turinoises – criminelles comme civiles – avec leur souci de prouver l’ancrage et la stabilité des individus dans le tissu urbain, face à une grande mobilité de la population, nous permettent d’apporter un nouveau regard sur le rapport entre individus et pratiques des métiers dans les milieux urbains d’Ancien Régime.This paper aims to use trial and justice archives, not to return to a social history of crime, but to question the system of norms and values at the core of professional paths (specifically crafts of individuals and families that lived or stayed temporarily in Turin in xviiith century.Scholars who studied “work” traditionally focused on guilds archives and underlined stability and continuity of work in the artisan ateliers. Yet, this historiography let in the shadow some interesting social phenomenon, moreover the nature of relation between professional and personal paths of artisans in the city, time and way of exercising crafts, the role played by individual and family life-cycle. Finally, in this paper I suggest that through the study of two justice and trial archives

Applying the payoff time framework to carotid artery disease management.

Science.gov (United States)

Yuo, Theodore H; Roberts, Mark S; Braithwaite, R Scott; Chang, Chung-Chou H; Kraemer, Kevin L

2013-11-01

and Asymptomatic stenosis of the carotid arteries is associated with stroke. Carotid revascularization can reduce the future risk of stroke but can also trigger an immediate stroke. The objective was to model the generic relationship between immediate risk, long-term benefit, and life expectancy for any one-time prophylactic treatment and then apply the model to the use of revascularization in the management of asymptomatic carotid disease. In the "payoff time" framework, the possibility of losing quality-adjusted life-years (QALYs) because of revascularization failure is conceptualized as an "investment" that is eventually recouped over time, on average. Using this framework, we developed simple mathematical forms that define relationships between the following: perioperative probability of stroke (P); annual stroke rate without revascularization (r0); annual stroke rate after revascularization, conditional on not having suffered perioperative stroke (r1); utility levels assigned to the asymptomatic state (ua) and stroke state (us); and mortality rates (λ). In patients whose life expectancy is below a critical life expectancy (CLE = P/(1-P)r0-r1, the "investment" will never pay off, and revascularization will lead to loss of QALYs, on average. CLE is independent of utilities assigned to the health states if a rank ordering exists in which ua > us. For clinically relevant values (P = 3%, r0 = 1%, r1 = 0.5%), the CLE is approximately 6.4 years, which is longer than published guidelines regarding patient selection for revascularization. In managing asymptomatic carotid disease, the payoff time framework specifies a CLE beneath which patients, on average, will not benefit from revascularization. This formula is suitable for clinical use at the patient's bedside and can account for patient variability, the ability of clinicians who perform revascularization, and the particular revascularization technology that is chosen.

Effect of Concomitant Medications on the Safety and Efficacy of Extended-Release Carbidopa-Levodopa (IPX066) in Patients With Advanced Parkinson Disease: A Post Hoc Analysis.

Science.gov (United States)

LeWitt, Peter A; Verhagen Metman, Leo; Rubens, Robert; Khanna, Sarita; Kell, Sherron; Gupta, Suneel

Extended-release (ER) carbidopa-levodopa (CD-LD) (IPX066/RYTARY/NUMIENT) produces improvements in "off" time, "on" time without troublesome dyskinesia, and Unified Parkinson Disease Rating Scale scores compared with immediate-release (IR) CD-LD or IR CD-LD plus entacapone (CLE). Post hoc analyses of 2 ER CD-LD phase 3 trials evaluated whether the efficacy and safety of ER CD-LD relative to the respective active comparators were altered by concomitant medications (dopaminergic agonists, monoamine oxidase B [MAO-B] inhibitors, or amantadine). ADVANCE-PD (n = 393) assessed safety and efficacy of ER CD-LD versus IR CD-LD. ASCEND-PD (n = 91) evaluated ER CD-LD versus CLE. In both studies, IR- and CLE-experienced patients underwent a 6-week, open-label dose-conversion period to ER CD-LD prior to randomization. For analysis, the randomized population was divided into 3 subgroups: dopaminergic agonists, rasagiline or selegiline, and amantadine. For each subgroup, changes from baseline in PD diary measures ("off" time and "on" time with and without troublesome dyskinesia), Unified Parkinson Disease Rating Scale Parts II + III scores, and adverse events were analyzed, comparing ER CD-LD with the active comparator. Concomitant dopaminergic agonist or MAO-B inhibitor use did not diminish the efficacy (improvement in "off" time and "on" time without troublesome dyskinesia) of ER CD-LD compared with IR CD-LD or CLE, whereas the improvement with concomitant amantadine failed to reach significance. Safety and tolerability were similar among the subgroups, and ER CD-LD did not increase troublesome dyskinesia. For patients on oral LD regimens and taking a dopaminergic agonist, and/or a MAO-B inhibitor, changing from an IR to an ER CD-LD formulation provides approximately an additional hour of "good" on time.

Local Water Management of Small Reservoirs: Lessons from Two Case Studies in Burkina Faso

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Hilmy Sally

2011-10-01

Full Text Available Burkina Faso is actively pursuing the implementation of Integrated Water Resources Management (IWRM in its development plans. Several policy and institutional mechanisms have been put in place, including the adoption of a national IWRM action plan (PAGIRE and the establishment so far of 30 local water management committees (Comités Locaux de l’Eau, or CLE. The stated purpose of the CLE is to take responsibility for managing water at sub-basin level. The two case studies discussed in this paper illustrate gaps between the policy objective of promoting IWRM on the one hand, and the realities associated with its practical on-the-ground implementation on the other. A significant adjustment that occurred in practice is the fact that the two CLE studied have been set up as entities focused on reservoir management, whereas it is envisioned that a CLE would constitute a platform for sub-basin management. This reflects a concern to minimise conflict and optimally manage the country’s primary water resource and illustrates the type of pragmatic actions that have to be taken to make IWRM a reality. It is also observed that the local water management committees have not been able to satisfactorily address questions regarding access to, and allocation of, water, which are crucial for the satisfactory functioning of the reservoirs. Water resources in the reservoirs appear to be controlled by the dominant user. In order to correct this trend, measures to build mutual trust and confidence among water users 'condemned' to work together to manage their common resource are suggested, foremost of which is the need to collect and share reliable data. Awareness of power relationships among water user groups and building on functioning, already existing formal or informal arrangements for water sharing are key determinants for successful implementation of the water reform process underway.

Anomalous Upwelling in Nan Wan: July 2008

Science.gov (United States)

2009-12-01

Head Ruth H. Preller 7300 Security, Code 1226 Office of Couns sl.Code 1008.3 ADOR/Director NCST E. R. Franchi , 7000 Public Affairs (Unclassified...State University (OSU) tidal forcing drives the tidal currents. A global weather forecast model (Navy Operational Global Atmospheric Prediction...system derives its open ocean boundary conditions from NRL global NCOM (Navy Co- astal Ocean Model) (Rhodes et al. 2002) that operates daily

Fully Adaptive Radar Modeling and Simulation Development

Science.gov (United States)

2017-04-01

using an object oriented programming (OOP) approach. It includes a FAR engine to control the operation of the perception-action (PA) cycle and...is unlimited 41 NATO North Atlantic Treaty Organization OOP object oriented programming OSU The Ohio State University PA perception-action PDF...development and testing on simulated, previously collected, and real-time streaming data. The architecture is coded in MATLAB using an object oriented

Déviance, justice et statistiques

OpenAIRE

Aubusson de Cavarlay, Bruno; Bosa, Bastien; Denord, François; François, Aurore; López, Laurent; Machiels, Christine; Margairaz, Dominique; Musin, Aude; Piant, Hervé; Vesentini, Frédéric; Zimnovitch, Henri

2007-01-01

Récidive, taux d’élucidation, enquêtes de victimation, reconduites à la frontière, allongement des peines, durée des procès : les chiffres de la police et de la justice font régulièrement la une des journaux. Cette médiatisation, et les guerres de chiffres qu’elle entraîne, ne sont pourtant pas propres à la France du XXIe siècle. Parmi les premières statistiques officielles publiées, dès le début du XIXe siècle dans certains pays européens, on compte celles des crimes et des procès. Leur pro...

MOLOSMES - Église paroissiale Saint-Marcel (anc. abbatiale Saint-Pierre - (canton de Tonnerre

Directory of Open Access Journals (Sweden)

2010-08-01

Full Text Available Molosmes, vue d’ensemble (cl. C. Arnaud.InterventionUne fouille de sauvetage urgent (SU a été mise en place à l’occasion de tranchées de drainage et reprise en sous-œuvre (travaux MH, Bruno Decaris sous la responsabilité de Bernadette Soum (AFAN pendant deux mois et demi en 1998.DescriptionLe siteUn monastère y aurait été fondé au vie siècle. L’actuelle église paroissiale est l’ancien édifice du monastère. Elle date de la première moitié du xvie siècle. L’ancienne église paroissiale, vend...

La manipulation du genre dans les pratiques discriminatoires

OpenAIRE

Delphy, Christine

2010-01-01

La constitution de castes raciales en France a commencé avec la colonisation de l’Afrique par la France au XIXe siècle. Dans le cas de la colonisation du Maghreb, le genre a joué un rôle éminent dans la nécessaire dépréciation des colonisés. La France du XXIe siècle refuse d’intégrer les descendants des immigrés et ex‑colonisés nord‑africains ; elle les constitue en caste inférieure et héréditaire définie par des traits culturels quasiment génétiques, et pour justifier ce traitement utilise u...

Angers: étude chrono-chorématique

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Benjamin Lefèvre

2010-12-01

Full Text Available La modélisation chrono-chorématique d’Angers (Maine-et-Loire du Ier siècle av. J.-C. au XIIIe siècle rend aisément lisibles les éléments majeurs de la topographie historique, dépassant le niveau du point pour atteindre celui de la surface. La confrontation des modèles obtenus permet de repérer les transformations et les persistances et met en évidence la dynamique urbaine. La confrontation avec des modèles théoriques replace Angers par rapport à un idéal-type et met en avant les spécificités propres à l’objet d’étude.

Les réseaux de la villégiature en France

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Bernard Toulier

2004-03-01

Full Text Available La création des stations de villégiature, balnéaires, thermales, climatiques ou des bords de ville s’inscrit à la fois dans le mouvement de l’avènement des loisirs et de la médicalisation de la société française du XIXe siècle, le développement des moyens de transport et l’accroissement exponentiel du tourisme.Figure 1Calais (Pas-de-Calais. Affiche, s.d. [fin XIXe siècle ?]. Coll. part. Extrait de Villes d’eaux, 2002. Paris : Imprimerie nationale Editions/Dexia, p. 30.Les réseaux de la villé...

Les peintures murales de Saint-Pierre de Colonzelle : une découverte récente dans le canton de Grignan (Drôme

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Geneviève Jourdan

2012-04-01

Full Text Available Eglise d'un prieuré clunisien mentionné dès le Xe siècle, la chapelle Saint-Pierre-ès-liens de Colonzelle est un petit édifice roman du XIIe siècle, isolé dans la plaine. Son plan très simple, à chevet semi-circulaire, n'a pas été modifié. La construction en petit appareil, aux pierres de parement hachurées ou à chevrons, est agrémentée de marques lapidaires et d'un sobre décor sculpté. Son intégrité lui a valu l'inscription à l'Inventaire supplémentaire des Monuments historiques en 1926.Rien...

Le baptistère du Puy-en-Velay (Haute-Loire

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Christian Sapin

2008-09-01

Full Text Available Traditionnellement désigné comme baptistère depuis le XIIIe siècle, cet édifice conservé au nord-est de la cathédrale du Puy est daté par la plupart des études antérieures du Xe siècle. En 2006, à partir du plan et des premiers travaux au sol, nous avions suggéré que les vestiges d’un massif quadrangulaire au niveau du sol, contre le mur nord, appartiennent à un rythme originel de piliers et grandes arcades murales, dont pouvaient subsister – selon les premières mesures d’espacement – des élé...

Chapitre 4. Matériaux de construction et de décoration

OpenAIRE

Harlé-Sambet, Yvonne; Cabart, Hubert; Charmoillaux, Julie; Girard, Ghislaine

2017-01-01

Si la brique apparaît comme le matériau le plus utilisé lors de la construction du château, on est cependant frappé par la variété des autres matériaux mis en œuvre. Les murs les plus anciens du logis est (XIIe siècle) ainsi que les fondations et le soubassement du château de brique (fin XIIIe siècle) sont constitués de maçonneries de galets liés au mortier. Le galet est en effet le matériau le plus fréquemment utilisé à toutes les époques dans les constructions du bas-Dauphiné. Cependant à B...

Chapitre VII. Naissance de la monumentalité, reproduction de la primitivité

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Coëffé, Vincent

2016-01-01

L’ÉMERGENCE D’UN EMBLÈME Au tournant du siècle, Matson décide d’étoffer son réseau de transport maritime, en créant des lignes destinées à la prise en charge de passagers. D’une manière plus globale, c’est toute l’infrastructure touristique qui connaît un développement inédit, les différents segments se dynamisant et se renforçant les uns les autres. Le début du xxe siècle voit ainsi l’émergence de structures d’accueil dont l’échelle était inconnue jusque-là à Waikiki. Walter Corbett Peacock,...

Les références culturelles des émigrants mexicains de la vallée de Barcelonnette : du grand magasin à la villa

Directory of Open Access Journals (Sweden)

Hélène Homps

2012-04-01

Full Text Available C’est au Mexique où ils émigrent massivement entre 1850 et 1950, alors qu’ils détiennent le monopole du commerce et de l’industrie textile, que les émigrants de la vallée de Barcelonnette font l’expérience de la modernité et découvrent le langage de l’architecture et son pouvoir de représentation. Acteurs du siècle si justement baptisé « siècle de l’Industrie » (François Loyer dans la jeune république fédérative des Etats-unis du Mexique (principalement sous le gouvernement de Porfirio Diaz,...

Les tours funéraires de Palmyre: la mémoire conservée d'anciens habitants

OpenAIRE

Chappaz, Jean-Luc

2015-01-01

Tiré du site internet du blog des Musées d'art et d'histoire (http://blog.mahgeneve.ch): "Victimes des récentes actions destructrices du groupe extrémiste État islamique (Daech), les tours funéraires typiques du paysage désertique de Palmyre apparurent à la fin de l'époque hellénistique (Ier siècle av. J.-C.) et furent érigées jusqu’au IIIe siècle de notre ère par les riches familles locales. Symboles de la réussite économique de la ville, elles étaient ornées par les bustes des défunts sculp...

Travaux et publications

OpenAIRE

M. Deville

2010-01-01

Ouvrages L'Oratoire à Angers aux xviie et xviiie siècles, Paris, 1975, 251 p. Le pouvoir municipal à Angers de 1657 à 1789, 2 vol., Angers, 1984, 293 et 348 p. Articles « La mission du père Honoré de Cannes à Angers en 1684 », Annales de Bretagne et des Pays de l'ouest (en abrégé ABPO dans les articles suivants), 1974, p. 501-516. « L'élection des maires d'Angers au xviiie siècle », Travaux sur le xviiie siècle, Angers, 1978, p 4-18. « Les messagers de l'université d'Angers dans la seconde mo...

Un proverbe comme 'conservatoire botanique' : le sésame en pays soninké (Sénégal, Mali, Mauritanie)

OpenAIRE

Chastanet, Monique

2013-01-01

A partir d'un proverbe soninké recueilli dans le haut Sénégal, j'ai reconstitué l'histoire d'une ancienne ressource, agricole et de cueillette. Il m'a fallu plusieurs années pour identifier la plante citée dans ce proverbe car elle n'était plus cultivée depuis le milieu du 20e siècle. J'ai pu le faire en croisant sources orales et sources écrites, notamment des archives du 18e et du 19e siècle. Une fois mise sur la piste du sésame, grâce à de nouvelles enquêtes et à différents travaux, j'ai c...

Cohabitation sociale et ordre public aux Champs-Élysées :Gestion et appropriation du carré des jeux (1700-1830)

OpenAIRE

Véronique Laporte

2011-01-01

Au 18e siècle et au début du 19e siècle, les Champs-Élysées sont ouverts à tous et attirent une clientèle diversifiée. Des joueurs issus d’horizons très différents s’y retrouvent pour pratiquer différentes activités, telles que la longue paume, les boules ou les barres. Afin que les promeneurs ne soient pas importunés par les jeux, ces derniers sont confinés dans une vaste clairière servant également lors des revues militaires et des fêtes publiques. Les autorités ont une volonté réelle d’off...

ANR Corpus architecturae religiosae europeae [CARE]saec. IV-X

Directory of Open Access Journals (Sweden)

Christian Sapin

2010-10-01

Full Text Available Le projet ANR «Corpus des monuments religieux antérieurs à l’an Mil» [Corpus architecturae religiosae europeae/CARE – IV-X saec.] a débuté en janvier 2008. Il représente l’apport de la France à un programme international, initié en 2002 par l’IRCLAMA de Zagreb (Croatie . Ce corpus a pour objectif de recenser les édifices religieux d’Europe entre le IVe siècle et le tout début du XIe siècle. Il regroupe déjà l’Italie, l’Espagne, la Croatie, l’Europe centrale et demain, probablement, l’Irlande...

Les usages du sucre dans le manuel de pharmacie de Cohen al-‘Aṭṭār médecin juif du Caire au XIIIe siècle

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Ouerfelli, Mohamed

2013-06-01

Full Text Available In the absence of a pharmaceutical guide for the usage of apothecaries and merchants of drugs and drinks, which took into account the evolution of pharmacy and the development of pharmaceutical products, Cohen al-‘Aṭṭar wrote a new manual in which he reminded us not only of the writings of his predecessors, but also the point of view of his contemporaries, notably his proper experiences he carried out in his shop in Cairo to make pharmaceutical products and the means to preserve them. This pharmaceutical manual, the richest in medicine formulas, also stands out on account of the extensive use of sugar in the making of recipes. Given the fact that this product was available in large quantities in Egypt and Syria during the second half of the 13th century, it gradually substituted honey to become the principal ingredient in the making of drugs and drinks. Thus, sugar broke through the food world to become the privilege of the royal class, who turned it into one of the essential elements for their festivities.[fr] Face à l’absence d’un guide pharmaceutique à l’usage des apothicaires et des marchands de drogues et de boissons, qui tient compte de l’évolution de la pharmacie et du développement de la matière médicale, Cohen al-‘Aṭṭār propose un nouveau manuel dans lequel il rappelle non seulement les écrits de ses prédécesseurs, mais il livre également les points de vue de ses contemporains, et surtout ses propres expériences, qu’il mène dans sa boutique du Caire, pour la confection des médicaments et les moyens de les conserver. Ce manuel pharmaceutique, le plus riche en formules médicamenteuses, se distingue également par l’usage massif du sucre dans l’élaboration des recettes. Ce produit, disponible en grandes quantités en Égypte et en Syrie pendant la seconde moitié du XIIIe siècle, se substitue progressivement au miel et devient l’ingrédient principal dans l’élaboration des médicaments et des

Kosmos l'épopée des particules

CERN Document Server

Letessier Selvon, Antoine

2017-01-01

À la fin du XIXe siècle, beaucoup de physiciens pensaient être arrivés au bout de leur discipline. La gravitation de Newton, la thermodynamique de Carnot, les équations de Maxwell : on pensait avoir tout compris ou presque. Il restait bien quelques observations inexpliquées, que l'on pensait être des points de détail. Il n'en était rien. . Au tout début du XXe siècle un phénomène anodin allait conduire les physiciens à la découverte des rayons cosmiques, ces particules extra-terrestres qui bombardent la Terre. Leur étude va les accompagner pendant près d'un siècle et les aider à formuler, à comprendre et à mettre en lumière de nouvelles théories. Pas à pas, l'observation attentive de ces rayons et de leurs propriétés nous guide vers d'étonnantes découvertes comme celle de l'antimatière. Peu à peu, le monde de la physique quantique s'ouvre à nous, servant de base arrière à la physique fondamentale moderne, et repoussant sans cesse les limites de nos connaissances. . C'est cette...

Kinetics of the Electric Discharge Pumped Oxygen-Iodine Laser

Science.gov (United States)

2011-09-01

of the sustainer pulse is tailored to keep the discharge stable. In January 2007, OSU demonstrated a peak laser power of 0.28 W, using a pulser...controlled avalanche ionization, Applied Physics Letters, 22, p. 670, (1973). (57) Hill. A.E., The next generation of controlled avalanche discharge ...pressure oxygen pulsed discharge . Simple and quick method for temperature determination, J. Phys. D:Appl. Phys. 32, pp. 246-250, (1998). (71

Chlorophyll-a, Aqua MODIS, OSU DB, 0.0125 degrees, West US

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — NOAA CoastWatch distributes chlorophyll-a concentration data from NASA's Aqua satellite. Measurements are gathered by the Moderate Resolution Imaging...

Refurbishment of the rotating rack of the OSU TRIGA MKII reactor

International Nuclear Information System (INIS)

Higginbotham, J.F.; Dodd, B.; Pratt, D.S.; Anderson, T.V.

1992-01-01

Many TRIGA reactors have experienced operational difficulties with the rotating racks used for sample irradiation. Generally the rack gradually becomes more difficult to rotate until it finally seizes. The recommended action at that point is replacement of the entire facility at a significant cost. The purpose of this paper is to describe the symptoms leading to rack failure and to present the results of a refurbishment procedure that does not involve the use of solvents which create mixed chemical and radioactive hazardous waste. The primary reason for rack failure is the buildup of sludge produced through irradiation of lubrication oil. The refurbishment procedure involves using a commercially available degreasing solution which can be pumped into and out of the rack with the objective of removing this sludge. The solution used is sold under the trade name 'Simple Green'. No radioactive material was detected on smear or air samples taken of the work area during the reifurbishment activities and the rack rotates freely in both direction even after eighteen months of operation. The only disadvantage to performing this procedure has been the need to maintain a very aggressive contamination control program when unloading samples from the rack. A very fine particulate material attaches to the outside of tubes used to encapsulate samples. This material can produce contamination levels of 10,000 dpm/100 cm 2 in the worst cases but will typically produce local hot spots on the order of 1000 dpm. (author)

FULL LENGTH RESEARCH ARTICLE Osue et al. (2008) SWJ:1-4 ...

African Journals Online (AJOL)

Dr. Ahmed

Current mass distribution of ivermectin to the ... antibodies, and the hazard of working with radioactive substances. .... using a modified protocol (Engelbrecht et al. .... in assumed endemic normal individuals show they have been exposed.

Les sources de l’histoire du patrimoine cultuel dans la seconde moitié du XXe siècle au Centre national des archives de l’Église de France

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Bernard Barbiche

2012-03-01

Full Text Available Fondé en 1973, installé à Issy-les-Moulineaux, le Centre national des archives de l'Église de France, service de la Conférence des évêques de France, est l'équivalent des Archives nationales pour l'État. Ses fonds datent majoritairement de la seconde moitié du XXe siècle, à quelques exceptions près. Dépôt central des archives de la Conférence épiscopale, le CNAEF reçoit ses archives et celles des comités qui en dépendent, mais aussi des dons divers (archives de mouvements ou de personnalités.Les documents touchant à l'histoire de l'art se trouvent plus particulièrement dans la section CO, répartis essentiellement dans les fonds du Comité national des constructions d'églises, le Comité national d'art sacré et le Centre national de pastorale liturgique. Ces fonds ne sont pas classés mais des répertoires sommaires sont consultables sur place, sachant que les délais de communication des documents varient entre 50 et 70 ans.The Centre national des archives de l’Eglise de France, the national archive centre for the French church, was founded in 1973 and is located today in the Paris suburb of Issy-les-Moulineaux. For the Catholic church in France, it is the equivalent of the national archives. With a few earlier exceptions, most of its holdings date from the second half of the 20th century. It is the central repository for the papers of the Episcopal Conference, and manages the papers of this institution and of the various committees attached to it. It also receives archives and papers by way of gifts from other organisations or personalities. The documents relating to art history are to be found mainly in the CO section, in particular in the papers of the Comité national des constructions d’églises (church building, the Comité national d’art sacré (sacred art and the Centre national de pastorale liturgique (pastoral liturgy. These holdings are not well ordered and certain documents cannot be divulged for 50 or

The CT appearances of delayed amniotic fluid clearance from the lungs in an infant with absent pulmonary valve and congenital lobar emphysema

International Nuclear Information System (INIS)

Fink, A. Michelle; Edis, Brian; Massie, John

2005-01-01

Congenital lobar emphysema (CLE) is a cause of severe neonatal respiratory distress. Overexpansion of the affected pulmonary lobe in the fetus is due to narrowing of the airway, with a resultant 'ball-valve' effect. At birth, there may be delayed clearance of fetal lung fluid. Early chest radiographs show opacification of the hyperexpanded lobe. The CT findings in the immediate neonatal period have not been previously reported. We describe the imaging in a neonate with tetralogy of Fallot and absent pulmonary valve with secondary CLE. CT demonstrates the hyperexpanded lobe with initial thickening of the interlobular septa and alveolar ground glass attenuation, with subsequent clearing. This resorption of fetal lung fluid via the pulmonary interstitium should not be confused with interstitial lung disease. (orig.)

The CT appearances of delayed amniotic fluid clearance from the lungs in an infant with absent pulmonary valve and congenital lobar emphysema

Energy Technology Data Exchange (ETDEWEB)

Fink, A. Michelle [Royal Children' s Hospital, Department of Medical Imaging, Parkville, Victoria (Australia); University of Melbourne, Melbourne, Victoria (Australia); Edis, Brian [Royal Children' s Hospital, Department of Cardiology, Parkville, Victoria (Australia); Massie, John [University of Melbourne, Melbourne, Victoria (Australia); Royal Children' s Hospital, Department of Respiratory Medicine, Parkville, Victoria (Australia); Murdoch Children' s Research Institute, Melbourne, Victoria (Australia)

2005-09-01

Congenital lobar emphysema (CLE) is a cause of severe neonatal respiratory distress. Overexpansion of the affected pulmonary lobe in the fetus is due to narrowing of the airway, with a resultant 'ball-valve' effect. At birth, there may be delayed clearance of fetal lung fluid. Early chest radiographs show opacification of the hyperexpanded lobe. The CT findings in the immediate neonatal period have not been previously reported. We describe the imaging in a neonate with tetralogy of Fallot and absent pulmonary valve with secondary CLE. CT demonstrates the hyperexpanded lobe with initial thickening of the interlobular septa and alveolar ground glass attenuation, with subsequent clearing. This resorption of fetal lung fluid via the pulmonary interstitium should not be confused with interstitial lung disease. (orig.)

Le traitement judiciaire de la jeunesse délinquante à Genève de 1738 à 17921

OpenAIRE

Bernasconi, Gianenrico

2009-01-01

Au cours des dernières années, la nécessité de dépasser la frontière chronologique qui situe la « naissance » de la délinquance juvénile au XIXe siècle s’est affirmée dans le débat historiographique. Certes le dispositif légal et institutionnel réservé aux mineurs se met en place au XIXe siècle, cependant l’étude de l’ancienne doctrine et des procédures criminelles genevoises de 1738 à 1792 révèle une pratique judiciaire sensible aux problèmes posés par la criminalité juvénile. Les magistrats...

Nietzsche entre Gide et Valéry

OpenAIRE

Large, Duncan

2017-01-01

Cette intervention a pour objet la réception et l’interprétation de Nietzsche chez deux auteurs qui dominaient la scène littéraire française dans la première moitié du XXe siècle: André Gide (1869-1951) et Paul Valéry (1871-1945). Ces deux écrivains exceptionnels – l’un, futur Prix Nobel, l’autre nominé pas moins de douze fois pour le même Prix et élu membre de l’Académie française – étaient au tournant du XXe siècle déjà des porte-étendards de l’avantgarde littéraire en France grâce à leurs ...

Un lieu saint et ses représentations : le Yaudet

OpenAIRE

Provost, Georges

2005-01-01

Cet article cherche à montrer comment a évolué, entre le début du XVIIe siècle et la fin du XXe siècle, la perception mentale d’un site archéologique et religieux : le Yaudet en Ploulec’h (Côtes-d’Armor), forteresse proto-historique et romaine abandonnée à partir du Moyen Âge mais relayée par un pèlerinage à la Vierge. Au fil des siècles, le Yaudet a été tantôt présenté comme le premier foyer de l’évangélisation chrétienne de la Bretagne ; comme un lieu de culte païen christianisé ; comme le ...

Le glaive de la parole

Directory of Open Access Journals (Sweden)

Luce Marchal-Albert

2006-09-01

Full Text Available Chacun sait, selon le mot de Pierre Viret, « en quelle confusion est la Chrestienté » au xvie siècle en Europe. C’est le deuxième quart du siècle qui nous intéressera ici, et en particulier l’année 1545, qui constitue une année charnière qui voit vaciller l’Église romaine, flamber et culminer la chasse aux hérétiques en même temps qu’elle voit la jeune Église réformée se renforcer et se positionner avec succès dans un champ religieux plus que chaotique. Les ouvrages polémiques réformés écrits...

L’affaire Scheffer : une victoire de la science contre le crime ? (octobre 1902

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Jean-Marc Berlière

2007-01-01

Full Text Available Alors que le dernier tiers du XIXe siècle découvre avec appréhension que « ce sont toujours les mêmes criminels qui commettent les mêmes crimes » et que « la prison fabrique des criminels », les récidivistes - qui représentent la moitié de la population pénale en France à la fin du siècle - sont à l’origine d’une véritable obsession et le « criminel d’habitude » devient la préoccupation majeure des juristes, pénalistes, médecins que l’on trouve aux origines de l’anthropologie criminelle et de...

Characteristic losses of electrons energy under reflection from leadsilicate glasses

International Nuclear Information System (INIS)

Gusarov, A.I.; Mashkov, V.A.; Pronin, V.P.; Tyutikov, A.M.

1986-01-01

The spectra of characteristic losses of energy (CLE) for the case of electron reflection from the surface of leadsilicate glasses of the composition xPbOx(1-x)SiO 2 , depending on molar concentration of lead oxide x, has been calculated for the first time. It is shown that the given model of glass energy structure permits to describe correctly general behaviour of CLE spectrum. However, the energy of plasma maximum measured experimentally remains approximately constant. The behaviour can be conditioned by ω 0 dependence on x[4], which has not been taken into account, and (or) by a slower change in ΔE, than it has been assumed. Further refining of theory and experiment is required to solve the problem

Sensitivity improvement of Cerenkov luminescence endoscope with terbium doped Gd{sub 2}O{sub 2}S nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Cao, Xin; Chen, Xueli, E-mail: xlchen@xidian.edu.cn, E-mail: jimleung@mail.xidian.edu.cn; Cao, Xu; Zhan, Yonghua; Liang, Jimin, E-mail: xlchen@xidian.edu.cn, E-mail: jimleung@mail.xidian.edu.cn [Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education and School of Life Science and Technology, Xidian University, Xi' an, Shaanxi 710071 (China); Kang, Fei; Wang, Jing [Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi' an, Shaanxi 710032 (China); Wu, Kaichun [Department of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi' an, Shaanxi 710032 (China)

2015-05-25

Our previous study showed a great attenuation for the Cerenkov luminescence endoscope (CLE), resulting in relatively low detection sensitivity of radiotracers. Here, a kind of radioluminescence nanoparticles (RLNPs), terbium doped Gd{sub 2}O{sub 2}S was mixed with the radionuclide {sup 68}Ga to enhance the intensity of emitted luminescence, which finally improved the detection sensitivity of the CLE by using the radioluminescence imaging technique. With the in vitro and in vivo pseudotumor experiments, we showed that the use of RLNPs mixed with the radionuclide {sup 68}Ga enabled superior sensitivity compared with the radionuclide {sup 68}Ga only, with 50-fold improvement on detection sensitivity, which guaranteed meeting the demands of the clinical diagnosis of gastrointestinal tract tumors.

Mike Davis, Génocides tropicaux. Catastrophes naturelles et famines coloniales (1870-1900. Aux origines du sous-développement, Paris, La Découverte, 2003, 479 p., trad. Late Victorian Holocausts, El Niño Famines and the Making of the Third World, 2001.

Directory of Open Access Journals (Sweden)

Cyrille Ferraton

2005-04-01

Full Text Available C’est à une histoire en grande partie négligée et méconnue qu’est consacré l’ouvrage de Mike Davis Génocides tropicaux publié en 2001 sous le titre Late Victorian Holocausts, El Niño Famines and the Making of the Third World. L’Inde, la Chine, le Brésil, l’Afrique du Nord, l’Afrique australe, les Philippines, en fait, un grand nombre de pays qu’Alfred Sauvy désignera en 1952 par pays du « tiers-monde », connurent à la fin du XIXe siècle et au tout début du XXe siècle trois périodes climatique...

Ellen Rutten, Unattainable Bride Russia - Gendering Nation, State, and Intelligentsia in Russian Intellectual Culture

Directory of Open Access Journals (Sweden)

Elise Hanut

2010-06-01

Full Text Available Dans cet ouvrage, Ellen Rutten nous guide à travers la littérature russe de la fin du XIXe siècle à nos jours à la recherche de la représentation allégorique de la Russie en tant que femme séduisante et, en ses termes, en tant « qu’épouse inaccessible ». En effet, à partir de la fin du XIXe siècle, les auteurs russes commencèrent à décrire la Russie en des termes féminins et utilisèrent fréquemment la métaphore de la femme-Russie. De nombreuses œuvres à ce sujet ont bien sûr déjà vu le jour, ...

Repeint et falsification

Directory of Open Access Journals (Sweden)

Barbara Greindl

2009-04-01

Full Text Available Le cas que nous évoquons ici a été abordé dans le cadre d’un travail de fin d’études en conservation-restauration. Nous nous sommes plus particulièrement arrêtée à la problématique essentiellement déontologique que posait un surpeint datant vraisemblablement du XIXe siècle. L’œuvre qui nous a été confiée est une nature morte du 17ème siècle provenant du Musée des Beaux-Arts de Tournai. Elle est réalisée à la peinture à l’huile sur un panneau de bois. Le panneau est composé de deux morceaux dé...

Le site laténien de Dautovac - Korićani et les fibules ornées de "boucles" ou de "huit" - "à brandebourgs"

Directory of Open Access Journals (Sweden)

Popović Petar D.

2002-01-01

Full Text Available (francuski Lors de sondages sur le site de Dautovac, près de Kragujevac, on a mis au jour un matériel archéologique appartenant à un habitat ouvert de la période de La Tène, daté de la fin du II ème et du Ier siècle av. n. è. Une fibule en fil de La Tène moyenne, avec enroulement décoratif, livrée par ce site est ici l'occasion de procéder à une brève analysede l'origine et de la diffusion des fibules de ce type spécifique du III ème/II ème siècle av. n. è.

Holistic Evaluation of Lightweight Operating Systems using the PERCU Method

Energy Technology Data Exchange (ETDEWEB)

Kramer, William T.C.; He, Yun (Helen); Carter, Jonathan; Glenski, Joseph; Rippe, Lynn; Cardo, Nicholas

2008-05-01

The scale of Leadership Class Systems presents unique challenges to the features and performance of operating system services. This paper reports results of comprehensive evaluations of two Light Weight Operating Systems (LWOS), Cray's Catamount Virtual Node (CVN) and Linux Environment (CLE) operating systems, on the exact same large-scale hardware. The evaluation was carried out over a 5-month period on NERSC's 19,480 core Cray XT-4, Franklin, using a comprehensive evaluation method that spans Performance, Effectiveness, Reliability, Consistency and Usability criteria for all major subsystems and features. The paper presents the results of the comparison between CVN and CLE, evaluates their relative strengths, and reports observations regarding the world's largest Cray XT-4 as well.

Guy Ducrey, Tout pour les yeux. Littérature et spectacle autour de 1900

OpenAIRE

Brangé, Mireille

2016-01-01

L’A. a ici réuni vingt-trois études: une inédite (Don Juan manipulé. Textes et mises en scènes de l’opéra au xixe siècle, pp. 239-254), les autres complétées après une première publication dans divers actes de colloques. L’entreprise restitue la complexité de ses travaux sur un aspect-clé de la littérature française au tournant du xxe siècle: le rapport du texte littéraire avec le spectacle silencieux, lieu de débat nullement inactuel selon l’A., qui voit dans sa non-résolution une explicatio...

Fulltext PDF

Indian Academy of Sciences (India)

Keywords. Nuclear level density; Monte Carlo method; collective rotation; single parti- cle levels. ... important aspect of both experimental and theoretical studies. The contributions .... where ni are the single particle occupation probabilities.

Testing of the multi-application small light water reactor (MASLWR) passive safety systems

International Nuclear Information System (INIS)

Reyes, Jose N.; Groome, John; Woods, Brian G.; Young, Eric; Abel, Kent; Yao, You; Yoo, Yeon Jong

2007-01-01

Experimental thermal hydraulic research has been conducted at Oregon State University for the purpose of assessing the performance of a new reactor design concept, the multi-application small light water reactor (MASLWR). The MASLWR is a pressurized light water reactor design with a net output of 35 MWe that uses natural circulation in both normal and transient operation. Due to its small size, portability and modularity, the MASLWR design is well suited to help fill the potential need for grid appropriate reactor designs for smaller electricity grids as may be found in developing or remote regions. The purpose of the OSU MASLWR test facility is to assess the operation of the MASLWR under normal full operating pressure and full temperature conditions and to assess the passive safety systems under transient conditions. The data generated by the testing program will be used to assess computer code calculations and to provide a better understanding of the thermal-hydraulic phenomena in the design of the MASLWR NSSS. During this testing program, four tests were conducted at the OSU MASLWR test facility. These tests included one design basis accident and one beyond design basis accident. During the performance of these tests, plant operations to include start up, normal operation and shut down evolutions were demonstrated successfully

Metal–organic complexation in the marine environment

Directory of Open Access Journals (Sweden)

Witter Amy

2001-09-01

Full Text Available We discuss the voltammetric methods that are used to assess metal–organic complexation in seawater. These consist of titration methods using anodic stripping voltammetry (ASV and cathodic stripping voltammetry competitive ligand experiments (CSV-CLE. These approaches and a kinetic approach using CSV-CLE give similar information on the amount of excess ligand to metal in a sample and the conditional metal ligand stability constant for the excess ligand bound to the metal. CSV-CLE data using different ligands to measure Fe(III organic complexes are similar. All these methods give conditional stability constants for which the side reaction coefficient for the metal can be corrected but not that for the ligand. Another approach, pseudovoltammetry, provides information on the actual metal–ligand complex(es in a sample by doing ASV experiments where the deposition potential is varied more negatively in order to destroy the metal–ligand complex. This latter approach gives concentration information on each actual ligand bound to the metal as well as the thermodynamic stability constant of each complex in solution when compared to known metal–ligand complexes. In this case the side reaction coefficients for the metal and ligand are corrected. Thus, this method may not give identical information to the titration methods because the excess ligand in the sample may not be identical to some of the actual ligands binding the metal in the sample.

La loi de la gravitation universelle Newton, Euler et Laplace Le cheminement d’une révolution scientifique vers une science normale

CERN Document Server

Schroeder, Prosper

2007-01-01

La Philosophiae Naturalis Principia Mathematica de Newton (1686), marquait-elle le début d'une révolution scientifique, ou était-elle la simple synthèse des idées d'un Kepler, Galilée ou Hooke? Une analyse des idées de Newton écarte cette hypothèse par le simple fait que les Principia cherchaient à démontrer la fausseté des approches antérieures. Pourtant, Newton subit un échec dans l'application de sa théorie de la gravitation à l'explication du mouvement de la Lune, échec qui marqua le développement de la mécanique céleste pendant tout le 18e siècle. Clairaut, d'Alembert et Euler doutaient de la validité de la loi newtonienne presque en même temps et leurs idées firent progresser la mécanique céleste qui atteignit l'état de «science normale» avec Le traité de mécanique céleste de Laplace, un siècle après Newton. Cet ouvrage relate cet épisode de l'histoire des sciences exactes au 18e siècle et fournit un exemple des théories épistémologiques toujours en vigueur aujourd...

The Use of Substances Other Than Nicotine in Electronic Cigarettes Among College Students

OpenAIRE

Deric R Kenne; Rebecca L Fischbein; Andy SL Tan; Mark Banks

2017-01-01

Introduction: Electronic cigarettes (e-cigarettes) have grown in popularity, especially among youth and young adults. Although e-cigarettes were originally intended to vaporize a liquid mixture containing nicotine, there appears to be an increasing trend in other substance use in e-cigarettes (OSUE). Materials and methods: Cross-sectional data from 1542 undergraduate college student e-cigarette users from a large Midwestern university were collected via online survey to assess prevalence of e...

Database Description - Gclust Server | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available ence and Technology of Japan Name: Research for the Future Program of the Japanese Society for Promotion of Science Reference(s) Arti...cle title: Gclust: trans-kingdom classification of prote

Fast stochastic simulation of biochemical reaction systems by alternative formulations of the chemical Langevin equation

KAUST Repository

Mélykúti, Bence; Burrage, Kevin; Zygalakis, Konstantinos C.

2010-01-01

The Chemical Langevin Equation (CLE), which is a stochastic differential equation driven by a multidimensional Wiener process, acts as a bridge between the discrete stochastic simulation algorithm and the deterministic reaction rate equation when

Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus

DEFF Research Database (Denmark)

Sigges, Johanna; Biazar, Cyrus; Landmann, Aysche

2013-01-01

The aim of this prospective, cross-sectional, multicentre study performed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) was to investigate different therapeutic strategies and their efficacies in cutaneous lupus erythematosus (CLE) throughout Europe. Using the EUSCLE Core Set...... Questionnaire, topical and systemic treatment options were analysed in a total of 1002 patients (768 females and 234 males) with different CLE subtypes. The data were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the criteria of the American College...... of Rheumatology (ACR) for the classification of systemic lupus erythematosus. Sunscreens were applied by 84.0% of the study cohort and showed a high efficacy in preventing skin lesions in all disease subtypes, correlating with a lower CLASI activity score. Topical steroids were used in 81.5% of the patients...

Le mélèze en Région wallonne. Etat des lieux et stations potentielles

OpenAIRE

Claessens, Hugues; Lecomte, H.; Pauwels, D.

2002-01-01

Le mélèze a été introduit en Belgique dans la deuxième moitié du XVIIIe siècle. Il s’agissait alors du mélèze d’Europe, surtout implanté à des fins esthétiques ou d’enrichissement de forêts feuillues. Quant au mélèze du Japon, il a été importé en Europe à la fin du XIXe siècle. Ce n’est qu’à partir des années ’50 que les mélèzes ont eu du succès auprès des sylviculteurs. Ils l’ont planté le plus souvent par parquets purs après d’autres résineux ou en transformation de peuplements feuillus de ...

Long-distance transport of signals during symbiosis

Science.gov (United States)

Xie, Zhi-Ping; Illana, Antonio

2011-01-01

Legumes enter nodule symbioses with nitrogen-fixing bacteria (rhizobia), whereas most flowering plants establish symbiotic associations with arbuscular mycorrhizal (AM) fungi. Once first steps of symbiosis are initiated, nodule formation and mycorrhization in legumes is negatively controlled by a shoot-derived inhibitor (SDI), a phenomenon termed autoregulation. According to current views, autoregulation of nodulation and mycorrhization in legumes is regulated in a similar way. CLE peptides induced in response to rhizobial nodulation signals (Nod factors) have been proposed to represent the ascending long-distance signals to the shoot. Although not proven yet, these CLE peptides are likely perceived by leucine-rich repeat (LRR) autoregulation receptor kinases in the shoot. Autoregulation of mycorrhization in non-legumes is reminiscent to the phenomenon of “systemic acquired resistance” in plant-pathogen interactions. PMID:21455020

Commerce et navigation dans l'Amérique Espagnole Coloniale: le port de Paita et le Pacifique au XVIIIème siècle

Directory of Open Access Journals (Sweden)

1993-01-01

Full Text Available À partir de sources fiscales - les registres de l’Almojarifazgo - cet article tente de retracer l’évolution du commerce maritime du port de Paita sur la côte nord du Pérou au 18ème siècle. Si les navires qui relâchent à Paita étaient en provenance ou à destination de la plupart des ports du Pacifique Sud, d’Acapulco à Pisco, la quasi totalité du trafic exprimé en valeur s’effectuait avec les trois ports du Panamá, de Guayaquil et du Callao. L’importation d’esclaves et l’exportation de l’écorce de quinine sont au cours de cette période les poids lourds du commerce par voie de mer. En appréciant la diversité et les quantités de marchandises exportées par Paita, cette étude essaye aussi d’évaluer la production d’un espace régional - le Corregimiento de Piura - pour lequel il n’existe à cette époque aucune autre source quantitative. COMERCIO Y NAVEGACIÓN EN LA AMÉRICA LATINA COLONIAL: EL PUERTO DE PAITA, PIURA Y EL PACÍFICO EN EL SIGLO 18. Basándose en los manuales de Almojarifazgos, este trabajo intenta seguir la evolución del tráfico marítimo a partir del puerto de Paita (norte del Perú en el siglo 18. Aunque los navíos que hacían escala en Paita tenían como origen y destino muchos puertos del Pacífico español, desde Acapulco hasta Pisco, la casi totalidad de los movimientos en valor se realizaba en los puertos de Panamá, Guayaquil y Callao. Durante este período, el movimiento comercial consistirá principalmente en la importación de esclavos y la exportación de quinina (cascarilla. A través del examen de las listas de embarque y de un intento de medir el volumen de las mercancías exportadas por Paita, el artículo se propone además evaluar la producción de una región del Perú colonial, el corregimiento de Piura, en una época para la cual no se encontraron otras fuentes cuantitativas. TRADE AND SHIPPING IN SPANISH COLONIAL AMERICA: THE PORT OF PAITA AND THE PACIFIC IN THE EIGHTEENTH

Les cartes des chemins de fer au Etats-Unis dans la deuxième moitié du 19ème siècle : quelques réflexions sur la représentation géographique et la géographie imaginaire

Directory of Open Access Journals (Sweden)

Mila DI NAPOLI-MARCHETTI

2009-07-01

Full Text Available Sous l’impulsion des voies ferrées se développa aux Etats-Unis, dans la seconde moitié du 19ème siècle, une activité cartographique sans précédent. La représentation d’une réalité géographique, sous couvert de procédés graphiques et techniques, ne révèlerait-elle pas un autre type de géographie ? La carte étant un outil de communication, les cartes des chemins de fer publiées à partir de 1853 aux Etats-Unis ne furent-elles pas un outil privilégié destiné à véhiculer de façon plus ou moins délibérée, sous couvert d’une représentation graphique matérialisée sous des formes diverses, un message à la fois d’information, de propagande ou de publicité à la gloire d’une réussite économique et politique ?In the second half of the 19th century, the United States transcontinental railroads stimulated an unprecedented cartographic activity. The representation of a geographical reality, hidden behind the mapping process, may lead to the disclosure of another and unexpected geography. Since any map is regarded as a tool of communication, the railroad maps, published in the United States since 1853, may be considered a privileged tool intended to convey a message of information, propaganda and advertising glorifying the economic and political success, hiding behind graphic representations featured in various forms.

Le procédé de blanchiment dans les ateliers monétaires français au XV-XVIème siècle: approche archéométrique et expérimentale

Directory of Open Access Journals (Sweden)

Téreygeol, Florian

2011-12-01

Full Text Available In the late nineties, excavations in La Rochelle (France have discovered the remains of a royal mint of the sixteenth century. This discovery enabled the collection of artefacts directly related to the manufacture of coins. The exceptional corpus gathered is the subject of a study of the chaîne opératoire of coining in the medieval time. Special attention is paid to an operation which takes place before the strike: the blanching of blanks. Well documented in ancient times, the samples from La Rochelle offer the opportunity to study this process during the medieval period and in a royal mint. In addition, thanks to reconstitution experiments, it is possible to define a reaction mechanism that helps to understand our historical observations.[fr] À la fin des années quatre-vingtdix, des fouilles menées à La Rochelle (France ont permis de mettre au jour les vestiges d’un atelier monétaire royal du XVIe siècle. Cette découverte a permis la collecte de matériel directement liée à la fabrication monétaire. Le corpus exceptionnel rassemblé est l’objet d’une étude qui vise à mettre en évidence la chaîne opératoire de fabrication de monnaie à l’époque considérée. Un intérêt particulier est porté à une technique d’argenture qui intervient avant la frappe des monnaies, le blanchiment des flans. Bien documenté pour les périodes antiques, le matériel de La Rochelle offre la possibilité de mettre en évidence ce procédé pour une période plus récente et dans un cadre officiel. De plus, à partir d’expériences de reconstitution, il a été possible de proposer un mécanisme réactionnel. Les hypothèses proposées permettent alors de dégager des implications historiques dans le procédé de fabrication.

Processing and characterization of screen printing

Indian Academy of Sciences (India)

cle size distribution was determined through image analy- sis on 150 particles by .... estimated by Archimedes' method and boiling of samples impregnated with ... ilar qualitative behaviour, regardless of the powder content or milling treatment ...

to view fulltext PDF

Indian Academy of Sciences (India)

5Department of Physics and Centre for Theoretical Studies, Indian Institute of ... cle, we focus on the theoretical models of reionization that have been ..... conceptual issues with these excursion set based approaches, e.g., violation of.

Infections, reproductive health, non - communicable diseases and ...

African Journals Online (AJOL)

cle on sexual health education among engaged couples11. The authors identified ... few hospitals had formal adult hospital-based triage, with staff performing ... tics of HIV opportunistic infections among older adults in Nigeria. Afri Health Sci.

Microscale Enhancement of Heat and Mass Transfer for Hydrogen Energy Storage

Energy Technology Data Exchange (ETDEWEB)

Drost, Kevin [Oregon State Univ., Corvallis, OR (United States); Jovanovic, Goran [Oregon State Univ., Corvallis, OR (United States); Paul, Brian [Oregon State Univ., Corvallis, OR (United States)

2015-09-30

The document summarized the technical progress associated with OSU’s involvement in the Hydrogen Storage Engineering Center of Excellence. OSU focused on the development of microscale enhancement technologies for improving heat and mass transfer in automotive hydrogen storage systems. OSU’s key contributions included the development of an extremely compact microchannel combustion system for discharging hydrogen storage systems and a thermal management system for adsorption based hydrogen storage using microchannel cooling (the Modular Adsorption Tank Insert or MATI).

Using Open Source Tools to Create a Mobile Optimized, Crowdsourced Translation Tool

OpenAIRE

Evviva Weinraub Lajoie; Trey Terrell; Susan McEvoy; Eva Kaplan; Ariel Schwartz; Esther Ajambo

2014-01-01

In late 2012, OSU Libraries and Press partnered with Maria's Libraries, an NGO in Rural Kenya, to provide users the ability to crowdsource translations of folk tales and existing children's books into a variety of African languages, sub-languages, and dialects. Together, these two organizations have been creating a mobile optimized platform using open source libraries such as Wink Toolkit (a library which provides mobile-friendly interaction from a website) and Globalize3 to allow for multipl...

Preparation and investigation of Al–4 wt % B4C nanocomposite ...

Indian Academy of Sciences (India)

cal behaviour including light weight, electrical and thermal conductivity (Boey et ... cle sizes, density, geometries, flow or the development of an electrical charge ... 2. Experimental. Argon gas atomized Al–2 wt % Cu powders with a mean size.

Unique and Conserved Features of the Barley Root Meristem

Directory of Open Access Journals (Sweden)

Gwendolyn K. Kirschner

2017-07-01

Full Text Available Plant root growth is enabled by root meristems that harbor the stem cell niches as a source of progenitors for the different root tissues. Understanding the root development of diverse plant species is important to be able to control root growth in order to gain better performances of crop plants. In this study, we analyzed the root meristem of the fourth most abundant crop plant, barley (Hordeum vulgare. Cell division studies revealed that the barley stem cell niche comprises a Quiescent Center (QC of around 30 cells with low mitotic activity. The surrounding stem cells contribute to root growth through the production of new cells that are displaced from the meristem, elongate and differentiate into specialized root tissues. The distal stem cells produce the root cap and lateral root cap cells, while cells lateral to the QC generate the epidermis, as it is typical for monocots. Endodermis and inner cortex are derived from one common initial lateral to the QC, while the outer cortex cell layers are derived from a distinct stem cell. In rice and Arabidopsis, meristem homeostasis is achieved through feedback signaling from differentiated cells involving peptides of the CLE family. Application of synthetic CLE40 orthologous peptide from barley promotes meristem cell differentiation, similar to rice and Arabidopsis. However, in contrast to Arabidopsis, the columella stem cells do not respond to the CLE40 peptide, indicating that distinct mechanisms control columella cell fate in monocot and dicot plants.

Constructivist-Visual Mind Map Teaching Approach and the Quality of Students' Cognitive Structures

Science.gov (United States)

Dhindsa, Harkirat S.; Makarimi-Kasim; Roger Anderson, O.

2011-04-01

This study compared the effects of a constructivist-visual mind map teaching approach (CMA) and of a traditional teaching approach (TTA) on (a) the quality and richness of students' knowledge structures and (b) TTA and CMA students' perceptions of the extent that a constructivist learning environment (CLE) was created in their classes. The sample of the study consisted of six classes (140 Form 3 students of 13-15 years old) selected from a typical coeducational school in Brunei. Three classes (40 boys and 30 girls) were taught using the TTA while three other classes (41 boys and 29 girls) used the CMA, enriched with PowerPoint presentations. After the interventions (lessons on magnetism), the students in both groups were asked to describe in writing their understanding of magnetism accrued from the lessons. Their written descriptions were analyzed using flow map analyses to assess their content knowledge and its organisation in memory as evidence of cognitive structure. The extent of CLE was measured using a published CLE survey. The results showed that the cognitive structures of the CMA students were more extensive, thematically organised and richer in interconnectedness of thoughts than those of TTA students. Moreover, CMA students also perceived their classroom learning environment to be more constructivist than their counterparts. It is, therefore, recommended that teachers consider using the CMA teaching technique to help students enrich their understanding, especially for more complex or abstract scientific content.

Molecular confocal laser endomicroscopy: a novel technique for in vivo cellular characterization of gastrointestinal lesions.

Science.gov (United States)

Karstensen, John Gásdal; Klausen, Pia Helene; Saftoiu, Adrian; Vilmann, Peter

2014-06-28

While flexible endoscopy is essential for macroscopic evaluation, confocal laser endomicroscopy (CLE) has recently emerged as an endoscopic method enabling visualization at a cellular level. Two systems are currently available, one based on miniprobes that can be inserted via a conventional endoscope or via a needle guided by endoscopic ultrasound. The second system has a confocal microscope integrated into the distal part of an endoscope. By adding molecular probes like fluorescein conjugated antibodies or fluorescent peptides to this procedure (either topically or systemically administered during on-going endoscopy), a novel world of molecular evaluation opens up. The method of molecular CLE could potentially be used for estimating the expression of important receptors in carcinomas, subsequently resulting in immediate individualization of treatment regimens, but also for improving the diagnostic accuracy of endoscopic procedures by identifying otherwise invisible mucosal lesions. Furthermore, studies have shown that fluorescein labelled drugs can be used to estimate the affinity of the drug to a target organ, which probably can be correlated to the efficacy of the drug. However, several of the studies in this research field have been conducted in animal facilities or in vitro, while only a limited number of trials have actually been carried out in vivo. Therefore, safety issues still needs further evaluations. This review will present an overview of the implications and pitfalls, as well as future challenges of molecular CLE in gastrointestinal diseases.

Author: MA du Plessis CLINICAL LEGAL EDUCATION MODELS ...

African Journals Online (AJOL)

21892687

http://www.nuigalway.ie/business-public-policy-law/school-of-law/students/cle/. .... ...clinical legal education of final year LLB students, with the focus on analytical ..... Spot tests and minute papers can be applied successfully during student ...

Comparison of CRISPR/Cas9 expression constructs for efficient targeted mutagenesis in rice.

Science.gov (United States)

Mikami, Masafumi; Toki, Seiichi; Endo, Masaki

2015-08-01

The CRISPR/Cas9 system is an efficient tool used for genome editing in a variety of organisms. Despite several recent reports of successful targeted mutagenesis using the CRISPR/Cas9 system in plants, in each case the target gene of interest, the Cas9 expression system and guide-RNA (gRNA) used, and the tissues used for transformation and subsequent mutagenesis differed, hence the reported frequencies of targeted mutagenesis cannot be compared directly. Here, we evaluated mutation frequency in rice using different Cas9 and/or gRNA expression cassettes under standardized experimental conditions. We introduced Cas9 and gRNA expression cassettes separately or sequentially into rice calli, and assessed the frequency of mutagenesis at the same endogenous targeted sequences. Mutation frequencies differed significantly depending on the Cas9 expression cassette used. In addition, a gRNA driven by the OsU6 promoter was superior to one driven by the OsU3 promoter. Using an all-in-one expression vector harboring the best combined Cas9/gRNA expression cassette resulted in a much improved frequency of targeted mutagenesis in rice calli, and bi-allelic mutant plants were produced in the T0 generation. The approach presented here could be adapted to optimize the construction of Cas9/gRNA cassettes for genome editing in a variety of plants.

Science-Based Simulation Model of Human Performance for Human Reliability Analysis

International Nuclear Information System (INIS)

Kelly, Dana L.; Boring, Ronald L.; Mosleh, Ali; Smidts, Carol

2011-01-01

Human reliability analysis (HRA), a component of an integrated probabilistic risk assessment (PRA), is the means by which the human contribution to risk is assessed, both qualitatively and quantitatively. However, among the literally dozens of HRA methods that have been developed, most cannot fully model and quantify the types of errors that occurred at Three Mile Island. Furthermore, all of the methods lack a solid empirical basis, relying heavily on expert judgment or empirical results derived in non-reactor domains. Finally, all of the methods are essentially static, and are thus unable to capture the dynamics of an accident in progress. The objective of this work is to begin exploring a dynamic simulation approach to HRA, one whose models have a basis in psychological theories of human performance, and whose quantitative estimates have an empirical basis. This paper highlights a plan to formalize collaboration among the Idaho National Laboratory (INL), the University of Maryland, and The Ohio State University (OSU) to continue development of a simulation model initially formulated at the University of Maryland. Initial work will focus on enhancing the underlying human performance models with the most recent psychological research, and on planning follow-on studies to establish an empirical basis for the model, based on simulator experiments to be carried out at the INL and at the OSU.

Climate and transboundary water management issues

International Nuclear Information System (INIS)

Bjonback, D.

1991-01-01

The potential effects of climate change on transboundary river systems, major water uses, interjurisdictional arrangements, and water issues affecting water management in the Great Plains of Canada are discussed. Three atmospheric general circulation models (GCM) have been applied for a two times carbon dioxide concentration scenario for the Saskatchewan River system. The models were the Goddard Institute for Space Studies (GISS) model, the Geophysical Fluid Dynamics Laboratory (GFDL) model, and the Oregon State University (OSU) model. For all models, soil moisture on the plains was reduced. The GISS model predicted slightly higher runoff for plains-originating streams, and a substantial increase in runoff (32%) in the Rockies. The GFDL model predicted lower runoffs in the plains and Rockies, with some locations near the Alberta-Saskatchewan border indicating zero runoff. The OSU model results generally bracketed the GISS and GFDL results, with total runoff approximating 1951-1980 mean. The GISS model indicated an increase in net basin supply of 28%, while the GFDL model, due to lower runoff and high soil moisture defecits, showed a decrease of 38%. For policy making, monitoring, and research, the GFDL model results can provide important guidelines. Greater attention to demand management and conservation will have short-term benefits in stretching the limited water resource base to support a larger economy, while providing flexibility to cope with future climate as it evolves. 1 ref

The Boston Assessment of Traumatic Brain Injury-Lifetime (BAT-L) semistructured interview: evidence of research utility and validity.

Science.gov (United States)

Fortier, Catherine Brawn; Amick, Melissa M; Grande, Laura; McGlynn, Susan; Kenna, Alexandra; Morra, Lindsay; Clark, Alexandra; Milberg, William P; McGlinchey, Regina E

2014-01-01

Report the prevalence of lifetime and military-related traumatic brain injuries (TBIs) in Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) veterans and validate the Boston Assessment of TBI-Lifetime (BAT-L). The BAT-L is the first validated, postcombat, semistructured clinical interview to characterize head injuries and diagnose TBIs throughout the life span. Community-dwelling convenience sample of 131 OEF/OIF veterans. TBI criteria (alteration of mental status, posttraumatic amnesia, and loss of consciousness) were evaluated for all possible TBIs, including a novel evaluation of blast exposure. BAT-L, Ohio State University TBI Identification Method (OSU-TBI-ID). About 67% of veterans incurred a TBI in their lifetime. Almost 35% of veterans experienced at least 1 military-related TBI; all were mild in severity, 40% of them were due to blast, 50% were due to some other (ie, blunt) mechanism, and 10% were due to both types of injuries. Predeployment TBIs were frequent (45% of veterans). There was strong correspondence between the BAT-L and the OSU-TBI-ID (Cohen κ = 0.89; Kendall τ-b = 0.95). Interrater reliability of the BAT-L was strong (κs >0.80). The BAT-L is a valid instrument with which to assess TBI across a service member's lifetime and captures the varied and complex nature of brain injuries across OEF/OIF veterans' life span.

Intuition et déduction en mathématiques

CERN Document Server

Leclercq, Bruno

2015-01-01

À la fin du XVIIIe siècle, Emmanuel Kant pouvait encore voir dans les mathématiques le modèle même des jugements synthétiques a priori, c'est-à-dire dotés d'un contenu intuitif propre quoique non dérivé de l'expérience sensible. Des géométries non-euclidiennes à la théorie des transfinis de Cantor, les mathématiques du XIXe siècle vont cependant faire triompher des systèmes mathématiques résolument déductifs et non plus intuitifs. Sur fond d'interrogations quant à la légitimité de ces développements récents, interrogations renforcées par la découverte de paradoxes, d'âpres débats vont alors o

2017 MYM posters.pmd

Indian Academy of Sciences (India)

Administrator

Gagandeep Kang works on enteric infections in children, particularly on ... life in fin de siécle Benares, the Swadeshi movement with its epicenter in Bengal, his friendship with Aurobindo, his wide and eclectic reading in the World literature,.

352-IJBCS-Article-Dr Dibong Siegfried Didier

African Journals Online (AJOL)

Dr Gatsing

en Europe depuis le dix-neuvième siècle est très recommandé dans la ..... potentielle avec une nutrition normale, les .... Annales des Sciences. Naturelles ... Flavonoids chemistry metabolism, cardioprotective ... forests: A case study of Douala.

Chlorophyll-a, Terra MODIS, OSU DB, 0.0125 degrees, West US, EXPERIMENTAL

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — NOAA CoastWatch distributes chlorophyll-a concentration data from NASA's Terra satellite. Measurements are gathered by the Moderate Resolution Imaging...

Compliance with federal and state regulations regarding the emergency response plan and physical security plan at the Oregon State TRIGA reactor

International Nuclear Information System (INIS)

Johnson, A.G.; Ringle, J.C.; Anderson, T.V.

1976-01-01

Recent legislative actions within the State of Oregon have had a significant impact upon the OSU TRIGA Emergency Response Plan, and to a lesser extent upon the Physical Security Plan. These state imposed changes will be reviewed in light of existing federal requirements. With the upcoming acquisition of FLIP fuel in August 1976, NRC required several major changes to the existing Physical Security Plan. Within the limitations of public disclosure, these changes will be contrasted to the present plan. (author)

« Il faut qu’un party se sente bien faible quand il accepte et qu’il recherche de tels appuis ». Femmes, jansénisme et publicité à Paris au xviiie siècle

Directory of Open Access Journals (Sweden)

Nicolas Lyon-Caen

2009-07-01

Full Text Available Le jansénisme devient, au siècle des Lumières, une déviance publique et donnée à voir à travers les lieux de la Ville. La présence féminine est évidente mais varie selon lessources car l’influence féminine n’est pas simplement tacite, mais constitue bel et bien un droit reconnu et sanctionné par des usages. Les institutions urbaines d’ancien régime sont cependant résolument masculines et l’impuissance des femmes réside plutôt dans leur extériorité au langage de celles-ci, sans que cela les empêche de faire « comme les hommes ». Mais leur investissement effectif dans la cause janséniste pose de manière récurrente, et insoluble, la question de leur rôle politique dans une société de plus en plus travaillée par le problème de la représentation.Contrary to the idea that associates religious deviance or minority with secrecy, Jansenism offers a different case study. During the eighteenth century Jansenists made their deviance public throughout the city of Paris, the major manifestation of which being the pilgrimage to the tomb of Deacon François de Pâris. Even though women participated to the movement, different sources give little evidence, as female influence was not simply tacit, but indeed constituted a right acknowledged by uses. Yet, urban institutions membership was resolutely male, the impotence of women, in that case, can be explained by their being foreign to the discourse of municipal bodies, which did not prevent them from acting “like men”. Therefore, the effective female investment in the Jansenist cause regularly posed the insoluble problem of their political role in a society in which the issue of representation became crucial.

Cutaneous lupus erythematosus and the risk of deep venous thrombosis and pulmonary embolism

DEFF Research Database (Denmark)

Ahlehoff, O; Wu, Jashin J; Raunsø, Jakob

2017-01-01

Background Venous thromboembolism (VTE) is a major public health concern. Lupus erythematosus (LE) is a chronic autoimmune disease ranging from localized cutaneous disease (CLE) to systemic involvement (SLE). Patients with SLE have an increased risk of venous thromboembolism (VTE), but little...

A national stakeholder consensus study of challenges and priorities for clinical learning environments in postgraduate medical education

NARCIS (Netherlands)

Kilty, Caroline; Wiese, Anel; Bergin, Colm; Flood, Patrick; Fu, Na; Horgan, Mary; Higgins, Agnes; Maher, Bridget; O’Kane, Grainne; Prihodova, Lucia; Slattery, Dubhfeasa; Stoyanov, Slavi; Bennett, Deirdre

2018-01-01

Background: High quality clinical learning environments (CLE) are critical to postgraduate medical education (PGME). The understaffed and overcrowded environments in which many residents work present a significant challenge to learning. The purpose of this study was to develop a national expert

Cutaneous lupus erythematosus and systemic lupus erythematosus are associated with clinically significant cardiovascular risk

DEFF Research Database (Denmark)

Hesselvig, J Halskou; Ahlehoff, O; Dreyer, L

2017-01-01

Systemic lupus erythematosus (SLE) is a well-known cardiovascular risk factor. Less is known about cutaneous lupus erythematosus (CLE) and the risk of developing cardiovascular disease (CVD). Therefore, we investigated the risk of mortality and adverse cardiovascular events in patients diagnosed...

Desenvolvimento vegetativo, produção e qualidade de frutos da tangerina 'Fremont' sobre quatro porta-enxertos Growth, yield and fruit quality of 'Fremont' mandarin on four rootstocks

Directory of Open Access Journals (Sweden)

Erick Espinoza Núñez

2007-08-01

Full Text Available Com o objetivo de avaliar o desenvolvimento vegetativo, produção e qualidade de frutos da tangerina 'Fremont' (C. clementina Hort. ex Tan. X C. reticulata Blanco sobre os porta-enxertos limão 'Cravo' (C. limonia Osbeck, citrumelo 'Swingle' (P. trifoliata Raf. x C. paradisi Macf., tangerina 'Cleópatra' (Citrus reshni Hort. ex Tan. e tangelo 'Orlando' (C. reticulata Blanco x C. paradisi Macf., foi instalado um experimento em Bebedouro-SP, em 1997. Embora diferenças na produção tenham sido registradas em função dos porta-enxertos, nos anos de 2003 a 2005, a produção acumulada nas safras de 2000 a 2006 não revelou influência dos mesmos. Os valores do índice de alternância de produção e eficiência de produção não foram influenciados pelos porta-enxertos. O teor de sólidos solúveis, bem como acidez total foram superiores nos frutos das plantas enxertadas sobre citrumelo 'Swingle' e tangerina 'Cleópatra'. Os valores de volume da copa e diâmetro do tronco foram superiores nas árvores sobre tangelo 'Orlando' e tangerina 'Cleópatra'.An experiment was installed in Bebedouro, SP, Brazil in 1997, with the aim of evaluate the effect of the rootstocks 'Rangpur' lime (C. limonia Osbeck, 'Swingle' citrumelo (P. trifoliata Raf. x C. paradisi Macf., 'Cleopatra' mandarin (Citrus reshni Hort. ex Tan. and 'Orlando' tangelo (C. reticulata Blanco x C. paradisi Macf. on plant growth, yield and fruit quality of 'Fremont' mandarin (C. clementina Hort. ex Tan. X C. reticulata Blanco. Despite that differences in yield have been registered related to the rootstocks between 2003 to 2005; cumulative yield from 2000 to 2006 seasons was not affected by the rootstock. Alternate bearing index and yield efficiency values were not influenced by the rootstocks. Fruits from trees on 'Swingle' citrumelo and 'Cleópatra' mandarin had higher values of total soluble solids concentration and total acids. Trunk diameter and canopy volume values were higher in

La production éditoriale de Benoît Rigaud et son catalogue chevaleresque

Directory of Open Access Journals (Sweden)

Francesco Montorsi

2014-12-01

Full Text Available La présente contribution se propose d’enquêter sur l’imprimeur-libraire Benoît Rigaud à la fois par le biais d’une étude de sa production globale et par une analyse portant sur ses impressions chevaleresques. Benoît Rigaud est l’un des éditeurs les plus prolifiques du XVIe siècle français, avec une activité qui s’étend sur plus que 40 ans et avec 1500 impressions environ. Entre 1572 et 1597, Rigaud publie de nombreux romans de chevalerie, à la fois médiévaux et renaissants, et devient l’un des imprimeurs les plus influents du marché chevaleresque de la fin du siècle. Après un préambule sur la réception des romans de chevalerie au XVIe siècle, la vaste production de Rigaud fait l’objet d’une analyse quantitative, avant que ne soit analysée la production des récits de chevalerie. Les données récoltées permettent de tirer des conclusions sur la dynamique éditoriale du genre chevaleresque ainsi que sur sa réception dans la seconde moitié du XVIe siècle.This research seeks to shed light on the publisher Benoît Rigaud both through a study of his global production and an analysis of his chivalry printed books. Benoît Rigaud is one of the most productive publishers of 16th century France, with an activity covering more than 40 years, years during which he printed around 1500 books. Moreover, between 1572 and 1597, Rigaud printed many chivalry romances, both medieval and modern texts, so that he became one of the main publishers of chivalry literature of that period. In this research, after some short remarks upon the reception of chivalry romances in 16th century, the large production of Rigaud is subject to a quantitative analysis. Then, his production of chivalry romances is studied more in detail. The collected data lead us to draw conclusions on the dynamic of the chivalry genre as well as on his reception in the second half of the 16th century.

Les techniques de détection en physique de l'infiniment petit

CERN Document Server

Vannucci, François

2018-01-01

Panorama des différentes techniques développées au cours du dernier siècle pour découvrir une à une les particules dites élémentaires. Voyage à travers l'histoire de la physique des particules.

Adjei et al.

African Journals Online (AJOL)

PUBLICATIONS1

cle sizes were batched and fired in an electric kiln to temperatures of 1050°C and 1180°C. The study revealed that ... rial stage needs high energy consumption but recycling glass ..... augment the other indigenous recycling proc- esses in the ...

La stigmatisation particulière du pédéraste passif dans les enquêtes de médecine légale dans la premiere partie du xixe siècle

Directory of Open Access Journals (Sweden)

Thierry Pastorello

2010-01-01

Full Text Available Les enquêtes de médecine légale dans la première partie du xixe siècle sont les premiers travaux envisageant la pratique de l’homosexualité masculine sous l’angle scientifique. Deux figures sont primordiales : le docteur Pierre-Jean-Georges Cabanis (1757-1808 membre des idéologues et qui entendait faire de la médecine la pièce maîtresse d’une science de l’homme et Ambroise Tardieu 1818-1879 professeur de médecine légale à Paris auteur d’un traité vu comme un aboutissement de ces études médico-légales. Il faut signaler l’influence de la phrénologie. Ces médecins définissent des stigmates physiques et moraux propres à la pratique de la pédérastie, surtout passive et à l’occasion définissent un personnage type. Ces discours relèvent d’abord d’une phraséologie morale et ils puisent leurs racines antérieurement. Cependant il faut aussi replacer ces discours stigmatisant la pédérastie passive dans le contexte de la construction de la virilité moderne. Il faut aussi placer la médecine légale dans le contexte de la médecine et de ses évolutions.The particular stigmatization of the passive pederast in the inquiries of forensic medecine in the first part of the XIX centuryForensic medicine in the first part of the 19th century investigations are first work considering the practice of male homosexuality in scientific terms. Two figures are crucial: the Dr. Pierre-Jean-Georges Cabanis (1757-1808 the ideologists member and intended to do medicine the centrepiece of a human science and Ambroise Tardieu 1818 - 1879 Professor of forensic medicine in Paris author of a treaty as a culmination of these forensic studies. It should be noted the influence of the phrenology. These physicians define physical stigma and moral own practice of pederasty, especially passive and during the define a type character. These speeches are firstly a moral phraseology and they draw their roots previously. However we also

Localités et historiographie. Le débat sur l'histoire de Sanremo au xviiie siècle

Directory of Open Access Journals (Sweden)

Vittorio Tigrino

2012-01-01

Full Text Available Ce travail est centré sur un cas, celui qui oppose au xviiie siècle le gouvernement de la République de Gênes à une des communautés de son territoire, Sanremo. Le conflit commence en 1729 avec la résistance de Sanremo à l'extension des certaines lois générales pour le commerce, et après 1753 se développe sur le plan international, avec des très fortes répercussions dans les relations diplomatiques entre la République et les cours européennes. Le conflit met en pleine lumière les stratégies de revendication impériale avancées par une partie des représentants de la communauté de Sanremo, avec l’aide de certains fonctionnaires impériaux, depuis longtemps défenseurs de la supériorité impériale sur toute la République.Ce cas est l’objet d'une intense production historico-juridique qui prend l’aspect d’un très grand nombre d'œuvres imprimées et manuscrites. Cette production offre une interprétation de l'histoire des rapports entre les deux villes où les éclaircissements juridictionnelles se mélangent à la revendication d'une identité historique et d'une légitimation politique locales.De telles controverses sont, en effet, des lieux d’observations stratégiques pour mesurer de quelle façon l'initiative locale se rencontre et conditionne la redéfinition des catégories politiques, juridiques et économiques (ce qui souligne l'importance stratégique de la lecture et de l'interprétation d'un fait à l'échelle analytique locale. Le recours à la contextualisation, à l'archive, permet de mieux saisir le complexe rapport entre la formalisation des oeuvres d'imprimerie et l’« agir » concret des parties adverses, et montre les dynamiques du litige qui, si l’on en restait à un point de vue général, seraient difficilement perceptibles.Ainsi, à partir de certaines données des archives, il est possible de comprendre clairement les moments et les façons par lesquels cette « imperialità » de

Congenital Lobar Emphysema - a radiological diagnosis at first glance?

International Nuclear Information System (INIS)

Wittig, D.; Benz-Bohm, G.; Rietschel, E.

2004-01-01

Congenital lobar emphysema (CLE) is a malformation of the lung of unknown etiology. The characteristic overdistension of the affected lobe leads to compression and displacement of adjacent normal lung tissue and mediastinum. In the majority of cases, symptoms appear during the neonatal period or in early childhood. Clinically, children present with signs of respiratory distress, frequently occurring with a superimposed lower respiratory tract infection that aggravates air trapping and renders the patient symptomatic. Rarely, CLE is diagnosed in adult patients who did not experience any symptoms during childhood. Knowledge of the disease is of importance because in the majority of cases a plain chest radiograph together with clinical signs is sufficient to diagnose the disease correctly. This article draws attention to this condition by presenting two children and one adult with congenitial lobar emphysema. Possible clinical symptoms and diagnostic strategies are reviewed. (orig.) [de

Peculiarities of acronyms and shortenings

Directory of Open Access Journals (Sweden)

Dumitru MELENCIUC

2008-12-01

Full Text Available La deuxième moitié du XX-e siècle et le début du XXI-e siècle sont marqués par la présence de plus en plus visible dans tous les domaines de l’activité humaine des acronymes, des ”initialismes” et des abréviations: les problèmes sociaux, politiques, nationaux et internationaux, tout ce qui est lié à l’existence humaine, sont affectés par ce phénomène sociolinguistique. On peut affirmer sans réserves que l’importance des acronymes dans le processus de la communication humaine est incontestable. Dans le présent article les auteurs présentent les visions de différentes écoles linguistiques sur les particularités des unités terminologiques issues de ce type de formation.

Exercise-induced laryngeal obstructions: prevalence and symptoms in the general public

DEFF Research Database (Denmark)

Christensen, Pernille Melia; Thomsen, S F; Rasmussen, N

2011-01-01

Respiratory difficulties caused by exercise-induced laryngeal obstructions (EILOs) are reported with increasing frequency. The aim of this study was to assess the prevalence and symptoms of EILOs and their relation to airway hyperresponsiveness (AHR). In total, 556 randomly selected youths...... in Copenhagen aged 14-24 years were invited over a 2-year period. The study included a mailed questionnaire and two visits: day 1 (an interview-based questionnaire, methacholine bronchial provocation test and physical exertion test); and day 2 [an exercise test with continuous laryngoscopic recordings (CLE test......)]. The diagnosis of EILOs was based on the CLE test. In total, 237 answered the mailed questionnaire and 150 participated on day 1 whereof 98 participated on day 2 also. AHR was verified in 23 (4.1% of invitees) and EILOs in 42 (7.5% of invitees). Co-morbidity was verified in 6 cases (26.1% of verified AHR cases...

Not all infantile respiratory distress in winter is bronchiolitis: congenital lobar emphysema.

Science.gov (United States)

Taqvi, Laura; Griksaitis, Michael; Eastham, Katherine

2011-10-20

The authors report the case of a 4-week-old male infant presented during the winter period with respiratory distress. He had a 3 day history of cough and coryza, and a 2 day history of breathlessness and reduced feeding. He had evidence of tachypnoea, subcostal recession and hypoxia on examination. An initial diagnosis of bronchiolitis was made. The authors explore how the correct diagnosis of congenital lobar emphysema (CLE) was reached, highlighting key clinical signs and investigations. He had evidence of a hyperinflated right middle lobe, with collapse of right upper and lower lobes and left upper lobe with associated mediastinal shift on chest x-ray (CXR) and CT scan. He was referred to the regional Paediatric Cardiothoracic Centre where right middle lobectomy was performed with complete resolution of his respiratory distress and re-expansion of the compressed lobes on CXR. Current literature concerning CLE is reviewed.

Les accélérateurs de particules : vecteurs de découvertes, moteurs de développement.

CERN Multimedia

CERN. Geneva

2014-01-01

English version follows Les accélérateurs de particules : vecteurs de découvertes, moteurs de développement. par Dr. Philippe Lebrun Les accélérateurs de particules existent depuis plus d’un siècle comme instruments de recherche fondamentale qui ont permis la découverte des particules élémentaires et leur étude à des échelles toujours plus fines. Épousant les technologies émergentes dont ils ont stimulé les progrès, ils se sont développés de manière exponentielle tout au long du XXe siècle, pour être aujourd’hui les grands outils de la recherche en physique des particules, mais aussi – comme puissantes sources de rayonnements permettant de sonder la matière – en physique atomique et moléculaire, en physique d...

Une littérature du foyer : les livres de travaux manuels amateur

Directory of Open Access Journals (Sweden)

Claire Le Thomas

2008-04-01

Full Text Available Au cours du XIX e siècle naît une littérature entièrement voué au domicile : les manuels de travaux amateur. A travers ces livres se diffusent des usages dédiés à l’embellissement du logis ou à son entretien, c’est-à-dire de nouvelles occupations du temps libre qui accompagnent la transformation des représentations et des usages de l’espace domestique. Le mode d’exposition du discours sur la maison dans ces ouvrages amateur reflète ainsi l’intensité de l’engagement affectif et intellectuel concentré autour du foyer et dévoile la manière dont fut pensée et posée la problématique de l’habitat au cours de la seconde moitié du XIX e siècle.

Les feux de Pentecôte au royaume du Siècle. L’économie des charismes dans le pentecôtisme suédois

Directory of Open Access Journals (Sweden)

Emir Mahieddin

2012-09-01

Full Text Available Le pentecôtisme participe des mouvements de renouveau religieux qui ont amené, du fait de leur succès, à parler d’un « retour du refoulé » – selon les mots de Gilles Kepel –, une expression venue aujourd’hui remplacer le paradigme de la sécularisation, dominant en sociologie des religions depuis le début du XXe siècle. Cet article repose sur une étude ethnographique menée dans la ville de Jönköping, bastion du protestantisme born again dans un pays, la Suède, pourtant réputé le plus sécularisé du monde. L’auteur entend interroger les adaptations éventuelles que le pentecôtisme a pu mettre en place pour faire accepter sa présence au sein d’un environnement archi-sécularisé. Il apparaît ainsi que le « retour du religieux » ne s’appuie pas que sur une rhétorique du conflit ou de l’offensive avec l’idéologie de la sécularité mais tente une coexistence négociée avec son environnement d’accueil, aussi neutralisé d’influence religieuse soit-il.Pentecostalism is part of the revivalist movements that led, because of its success to speak of a « return of the repressed » – in the words of Gilles Kepel – an expression coming today to replace the paradigm of secularization, dominant in the sociology of religion since the beginning of the Twentieth century. This article is based on an ethnographic study conducted in the city of Jönköping, a bastion of born again Protestantism in one country, Sweden, reputedly the most secularized in the world. The author intends to examine the possible adaptations that Pentecostalism has set up to make his presence accepted in a very secular environment. It thus appears that the « return of religion » does not only rely on the rhetoric of conflict against the ideology of secularism but attempts to settle a negotiated coexistence with its hosting environment however free of religious influence that it might be.El pentecostalismo es parte de los

Un parfum d’Orient au cœur des villes d’eaux

Directory of Open Access Journals (Sweden)

Bernard Toulier

2012-04-01

Full Text Available Les villes balnéaires et thermales accordent une large place à l’orientalisme. En France, cet orientalisme a tendance à se confondre en grande partie avec l’histoire de la perception de l’architecture islamique. Il participe à la redécouverte du mythe méditerranéen conçu au XIXe siècle ; dans la seconde moitié du siècle, cette représentation se marie avec le goût éclectique. Au cours de la première moitié du XXe siècle, la référence à l’Orient est porteuse d’autres valeurs culturelles, sa présence se fait plus discrète et évolue vers une conception plus épurée et régionaliste, qui se veut intégrée au monde méditerranéen.Seaside and spa resorts had a serious weakness for orientalism. In France, this orientalism can be placed within a larger historical context of how Islamic architecture was perceived. It belongs to the rediscovery and redefinition of the Mediterranean myth during the 19th century. During the second half of this century, it was a style that blended well with eclectic tastes. During the first half of the 20th century, architectural references to the Orient came to bear other cultural values. The orientalism became more discreet and evolved towards a style that was more refined and regionalist, seeing itself as an integral part of the Mediterranean world.

CO2 emission from soil after reforestation and application of sewage sludge

Directory of Open Access Journals (Sweden)

Janaina Braga Carmo

2014-09-01

Full Text Available This study aimed to quantify the carbon dioxide emissions from an Oxisol under degraded pasture located in Sorocaba, São Paulo State, Brazil. The treatments were: sewage sludge (LE, sewage sludge compost (CLE, mineral fertilizer (AM and no fertilization (T0. The experiment was conducted in a completely randomized block design with analysis of the effect of the four treatments (CLE, LE, and AM T0 with four replications. The application of sewage sludge, sewage sludge compost, mineral fertilizer and no fertilizer was statistically significant for the variables of height increase and stem height of Guanandi seedlings (Calophyllum brasiliense Cambessèdes - Calophyllaceae. Treatments showed significant differences in terms of CO2 emissions from soil. The CLE exhibited the highest CO2 fluxes, reaching a peak of 9.33±0.96 g C m- 2 day- 1 (p<0.0001, as well as the LE with a maximum CO2 flux of 6.35±1.17 C m- 2 day- 1 (p<0.005. The AM treatment (4.96±1.61 g C m- 2 day- 1 had the same statistical effect as T0 (5.33±0.49 g C m- 2 day- 1. CO2 fluxes were correlated with soil temperature in all treatments. However, considering the period of 172 days of evaluation, the total loss of C as CO2 was 2.7% for sewage sludge and 0.7% for the sewage sludge compost of the total C added with the application on soil.

A synthetic C16 omega-hydroxyphytoceramide improves skin barrier functions from diversely perturbed epidermal conditions.

Science.gov (United States)

Oh, Myoung Jin; Nam, Jin Ju; Lee, Eun Ok; Kim, Jin Wook; Park, Chang Seo

2016-10-01

Omega-hydroxyceramides (ω-OH-Cer) play a crucial role in maintaining the integrity of skin barrier. ω-OH-Cer are the primary lipid constituents of the corneocyte lipid envelope (CLE) covalently attached to the outer surface of the cornified envelope linked to involucrin to become bound form lipids in stratum corneum (SC). CLE becomes a hydrophobic impermeable layer of matured corneocyte preventing loss of natural moisturizing factor inside the corneocytes. More importantly, CLE may also play an important role in the formation of proper orientation of intercellular lipid lamellar structure by interdigitating with the intercellular lipids in a comb-like fashion. Abnormal barrier conditions associated with atopic dermatitis but also UVB-irradiated skins are known to have lowered level of bound lipids, especially ω-OH-Cer, which indicate that ω-OH-Cer play an important role in maintaining the integrity of skin barrier. In this study, protective effects of a novel synthetic C16 omega-hydroxyphytoceramides (ω-OH-phytoceramide) on skin barrier function were investigated. Epidermal barrier disruption was induced by UVB irradiation, tape-stripping in hairless mouse and human skin. Protective effect of damaged epidermis was evaluated using the measurement of transepidermal water loss and cohesion of SC. Increased keratinocyte differentiation was verified using cultured keratinocyte through western blot. Results clearly demonstrated that a synthetic C16 ω-OH-phytoceramide enhanced the integrity of SC and accelerated the recovery of damaged skin barrier function by stimulating differentiation process. In a conclusion, a synthetic C16 ω-OH-phytoceramide treatment improved epidermal homeostasis in several disrupted conditions.

[A comparison of the most used instruments to assess the quality of clinical learning environments of nursing students].

Science.gov (United States)

Nicotera, Raffaella; Altini, Pietro; Dimonte, Valerio

2017-01-01

. A comparison of the most used instruments to assess the quality of clinical learning environments of nursing students. A clinical learning environment (CLE) promotes the development of professional competences, of critical and diagnostic reasoning in future nurses, thus the continuous assessment of its quality is pivotal. To describe and compare the most used instruments to measure the nursing students' perception of the quality of CLEs. Six validated questionnaires were identified and compared: CLE (Clinical Learning Environment), CLEDI (Clinical Learning Environment Diagnostic Inventory), SECEE (Student Evaluation of Clinical Education Environment), CLEI (Clinical Learning Environment Inventory), CLES (Clinical Learning Environment and Supervision), CLES+T (Clinical Learning Environment and Supervision plus Teacher nurse). The following elements were described: conceptual framework, psychometric properties, dimensions explored, the more relevant constructs able to guarantee a high quality CLE: relations between students and ward staff; level of involvement of nurse coordinators; inclusion of the student in the ward team, ward climate, involvement of clinical teacher and feedback to the students. The only instrument that explores all the relevant constructs is the CLES+T. The involvement of clinical nurse teacher and nurse coordinator are the less explored dimensions. The questionnaires CLEI, CLES and CLES+T, validated in Italian and used in several learning environments share the following weaknesses: do not assess the feedback offered to the students, the students' satisfaction for the tutoring strategies and the role of different professionals in the students' learning. The analysis of strengths and weaknesses is the basis to start from to devise and validate a new questionnaire.

A role of TDIF peptide signaling in vascular cell differentiation is conserved among euphyllophytes

Directory of Open Access Journals (Sweden)

Yuki eHirakawa

2015-11-01

Full Text Available Peptide signals mediate a variety of cell-to-cell communication crucial for plant growth and development. During Arabidopsis thaliana vascular development, a CLE (CLAVATA3/EMBRYO SURROUNDING REGION-related family peptide hormone, TDIF (tracheary element differentiation inhibitory factor, regulates procambial cell fate by its inhibitory activity on xylem differentiation. To address if this activity is conserved among vascular plants, we performed comparative analyses of TDIF signaling in non-flowering vascular plants (gymnosperms, monilophytes and lycophytes. We identified orthologs of TDIF/CLE as well as its receptor TDR/PXY (TDIF RECEPTOR/PHLOEM INTERCALATED WITH XYLEM in Ginkgo biloba, Adiantum aethiopicum and Selaginella kraussiana by RACE-PCR. The predicted TDIF peptide sequences in seed plants and monilophytes were identical to that of A. thaliana TDIF. We examined the effects of exogenous CLE peptide-motif sequences of TDIF in these species. We found that liquid culturing of dissected leaves or shoots was useful for examining TDIF activity during vascular development. TDIF treatment suppressed xylem/tracheary element differentiation of procambial cells in G. bioloba and A. aethiopicum leaves. In contrast, neither TDIF nor putative endogenous TDIF inhibited xylem differentiation in developing shoots and rhizophores of S. kraussiana. These data suggest that activity of TDIF in vascular development is conserved among extant euphyllophytes. In addition to the conserved function, via liquid culturing of its bulbils, we found a novel inhibitory activity on root growth in the monilophyte Asplenium x lucrosum suggesting lineage-specific co-option of peptide signaling occurred during the evolution of vascular plant organs.

A multi-scale health impact assessment of air pollution over the 21st century.

Science.gov (United States)

Likhvar, Victoria N; Pascal, Mathilde; Markakis, Konstantinos; Colette, Augustin; Hauglustaine, Didier; Valari, Myrto; Klimont, Zbigniew; Medina, Sylvia; Kinney, Patrick

2015-05-01

Ozone and PM₂.₅ are current risk factors for premature death all over the globe. In coming decades, substantial improvements in public health may be achieved by reducing air pollution. To better understand the potential of emissions policies, studies are needed that assess possible future health impacts under alternative assumptions about future emissions and climate across multiple spatial scales. We used consistent climate-air-quality-health modeling framework across three geographical scales (World, Europe and Ile-de-France) to assess future (2030-2050) health impacts of ozone and PM₂.₅ under two emissions scenarios (Current Legislation Emissions, CLE, and Maximum Feasible Reductions, MFR). Consistently across the scales, we found more reductions in deaths under MFR scenario compared to CLE. 1.5 [95% CI: 0.4, 2.4] million CV deaths could be delayed each year in 2030 compared to 2010 under MFR scenario, 84% of which would occur in Asia, especially in China. In Europe, the benefits under MFR scenario (219000 CV deaths) are noticeably larger than those under CLE (109,000 CV deaths). In Ile-de-France, under MFR more than 2830 annual CV deaths associated with PM₂.₅ changes could be delayed in 2050 compared to 2010. In Paris, ozone-related respiratory mortality should increase under both scenarios. Multi-scale HIAs can illustrate the difference in direct consequences of costly mitigation policies and provide results that may help decision-makers choose between different policy alternatives at different scales. Copyright © 2015 Elsevier B.V. All rights reserved.

Oklahoma State University proposed Advanced Technology Research Center. Environmental Assessment

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-06-01

The Department of Energy (DOE) has prepared an Environmental Assessment (EA) evaluating the construction and equipping of the proposed Advanced Technology Research Center (ATRC) at Oklahoma State University (OSU) in Stillwater, Oklahoma. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement is not required.

Résultats de recherche | Page 442 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Economic Liberalization and Political Violence : Utopia or Dystopia ? Un ouvrage essentiel pour quiconque souhaite comprendre les conflits et le développement au XXIe siècle. James Putzel, Crisis States Research Centre, London School of Economics. Publication Date. 6 août 2010 ...

Rétention de Escberichia Coli d'une eau dïnfiltration en sol ...

African Journals Online (AJOL)

horizons cle sol, qui permettrait de prédire le degré de contamination ... growth rate of E. 00/2 during the growth phase varied ftom one soil horizon to anothcr and was relatively mon: ...... Microbiologie et Hygiène Alimentaires 11, 9-. 14.

Biogeochemical speciation of Fe in ocean water

NARCIS (Netherlands)

Hiemstra, T.; Riemsdijk, van W.H.

2006-01-01

The biogeochemical speciation of Fe in seawater has been evaluated using the consistent Non-Ideal Competitive Adsorption model (NICA¿Donnan model). Two types of data sets were used, i.e. Fe-hydroxide solubility data and competitive ligand equilibration/cathodic stripping voltammetry (CLE/CSV) Fe

CrossTalk, The Journal of Defense Software Engineering. Volume 28 Number 1. Jan/Feb 2015

Science.gov (United States)

2015-02-01

minority participation is low [24]. At UT Tyler, we conduct science camps for high-school girl students in the summer to encourage them to pursue STEM ...Intellectual Property Rights (Data Rights for commercial built software applications), CLE074 on Cybersecurity (March 2015 deployment), and CLL

Epidemiology of cutaneous lupus erythematosus and the associated risk of systemic lupus erythematosus

DEFF Research Database (Denmark)

Petersen, M Prütz; Möller, S; Bygum, A

2018-01-01

Objectives The objectives of this paper are to describe the epidemiology of cutaneous lupus erythematosus (CLE) and its subtypes in Denmark, and to investigate the probability of receiving a subsequent diagnosis of systemic lupus erythematosus (SLE) and the related time course. Methods A nationwide...

Fe-Binding Dissolved Organic Ligands in the Oxic and Suboxic Waters of the Black Sea

NARCIS (Netherlands)

Gerringa, L.J.A.; Rijkenberg, M.J.A.; Bown, J.; Margolin, A.R.; Laan, P.; De Baar, H.J.W.

2016-01-01

In the oxygen-rich layer of the Black Sea, above the permanent halocline, the Fe and nitrate concentrations are low where fluorescence is relatively high, indicating uptake by phytoplankton. In this study we used ligand exchange adsorptive cathodic stripping voltammetry (CLE-aCSV), using

Final Report for Project ``Theory of ultra-relativistic heavy-ion collisions''

Energy Technology Data Exchange (ETDEWEB)

Ulrich W. Heinz

2012-11-09

In the course of this project the Ohio State University group led by the PI, Professor Ulrich Heinz, developed a comprehensive theoretical picture of the dynamical evolution of ultra-relativistic heavy-ion collisions and of the numerous experimental observables that can be used to diagnose the evolving and short-lived hot and dense fireball created in such collisions. Starting from a qualitative understanding of the main features based on earlier research during the last decade of the twentieth century on collisions at lower energies, the group exploited newly developed theoretical tools and the stream of new high-quality data from the Relativistic Heavy Ion Collider at Brookhaven National Laboratory (which started operations in the summer of the year 2000) to arrive at an increasingly quantitative description of the experimentally observed phenomena. Work done at Ohio State University (OSU) was instrumental in the discovery during the years 2001-2003 that quark-gluon plasma (QGP) created in nuclear collisions at RHIC behaves like an almost perfect liquid with minimal viscosity. The tool of relativistic fluid dynamics for viscous liquids developed at OSU in the years 2005-2007 opened the possibility to quantitatively determine the value of the QGP viscosity empirically from experimental measurements of the collective flow patterns established in the collisions. A first quantitative extraction of the QGP shear viscosity, with controlled theoretical uncertainty estimates, was achieved during the last year of this project in 2010. OSU has paved the way for a transition of the field of relativistic heavy-ion physics from a qualitative discovery stage to a new stage of quantitative precision in the description of quark-gluon plasma properties. To gain confidence in the precision of our theoretical understanding of quark-gluon plasma dynamics, one must test it on a large set of experimentally measured observables. This achievement report demonstrates that we have, at

REIGNY, Actes diplomatiques du XIIe siècle

Directory of Open Access Journals (Sweden)

Marlène Hélias-Baron

2008-07-01

Full Text Available Tout a commencé en 1104 quand deux ermites, Guérin et Gérard, ont obtenu d’Anséric chevalier d’Avallon et de Guy de Noyers la terre de Saint-Pierre située à proximité de Joux-la-Ville, dans le diocèse d’Autun. Leur aura de sainteté attira des disciples et leur communauté, installée en un lieu fort humide, justement appelé Fons humidus, Fontemoy, se transforma progressivement en un petit monastère. A la mort du deuxième abbé, Julien, au cours de l’année 1128, comme de nombreuses autres communa...

La Mauritanie jusqu’au xxe siècle

OpenAIRE

Vanacker, Christiane

2013-01-01

De par sa situation, par les populations qu’elle rassemble, la République Islamique de Mauritanie apparaît en quelque sorte comme un trait d’union entre le monde maghrébin et le monde Noir. Cette vocation s’est précisée aux ixe-xie siècles mais c’est en fait toute l’histoire du pays qui est liée à celle de l’Afrique Méditerranéenne et de l’Afrique Occidentale. L’étude de l’évolution de la Mauritanie nous amène constamment à franchir le cadre strict des frontières qui sont les siennes à l’heur...

Benjamin Crémieux, xxe siècle

OpenAIRE

Brangé, Mireille

2016-01-01

Mieux connu comme passeur de la littérature italienne et traducteur de Pirandello, Svevo et Moravia, Benjamin Crémieux (1888-1944) fut, au lendemain de la Première Guerre, l’un des plus importants critiques de la NRF. Dans une large mesure, sa méthode ne différait guère de celle de Thibaudet, s’appuyant sur une restitution synthétique de l’époque et, en son sein, sur un jeu de rapprochements entre contemporains; puis sur une lecture de l’ensemble de l’œuvre; enfin sur un effort de compréhensi...

Strong leadership and teamwork drive culture and performance change: Ohio State University Medical Center 2000-2006.

Science.gov (United States)

Sanfilippo, Fred; Bendapudi, Neeli; Rucci, Anthony; Schlesinger, Leonard

2008-09-01

Several characteristics of academic health centers have the potential to create high levels of internal conflict and misalignment that can pose significant leadership challenges. In September 2000, the positions of Ohio State University (OSU) senior vice president for health sciences, dean of the medical school, and the newly created position of chief executive officer of the OSU Medical Center (OSUMC) were combined under a single leader to oversee the OSUMC. This mandate from the president and trustees was modeled after top institutions with similar structures. The leader who assumed the role was tasked with improving OSUMC's academic, clinical, and financial performance. To achieve this goal, the senior vice president and his team employed the service value chain model of improving performance, based on the premise that leadership behavior/culture drives employee engagement/satisfaction, leading to customer satisfaction and improved organizational performance. Implementing this approach was a seven-step process: (1) selecting the right leadership team, (2) assessing the challenges and opportunities, (3) setting expectations for performance and leadership behavior, (4) aligning structures and functions, (5) engaging constituents, (6) developing leadership skills, and (7) defining strategies and tracking goals. The OSUMC setting during this period provides an observational case study to examine how these stepwise changes, instituted by strong leadership and teamwork, were able to make and implement sound decisions that drove substantial and measurable improvements in the engagement and satisfaction of faculty and staff; the satisfaction of students and patients; and academic, clinical, and financial performance.

Nitrogen and sulfar desposition on regional and global scales: A multimodel evaluation

NARCIS (Netherlands)

Dentener, F.; Drevet, J.; Lamarque, J.F.; Bey, I.; Eickhout, B.; Fiore, A.M.; Hauglustaine, D.; Horowitz, L.W.; Krol, M.C.; Kulshrestha, U.C.; Lawrence, M.; Galy-Lacaux, C.; Rast, S.; Shindell, D.; Stevenson, D.; Noije, van T.; Atherton, C.; Bell, N.; Bergman, D.; Butler, T.; Cofala, J.; Collins, B.; Doherty, R.; Ellingsen, K.; Galloway, J.; Gauss, M.; Montanaro, V.; Müller, J.F.; Pitari, G.; Rodriguez, J.; Sanderson, M.; Solmon, F.; Strahan, S.; Schultz, M.; Sudo, K.; Szopa, S.; Wild, O.

2006-01-01

We use 23 atmospheric chemistry transport models to calculate current and future (2030) deposition of reactive nitrogen (NOy, NHx) and sulfate (SOx) to land and ocean surfaces. The models are driven by three emission scenarios: (1) current air quality legislation (CLE); (2) an optimistic case of the

Homosexualité et esprit fort dans la première moitié du xviie siècle : indices poétiques d’une « invisible affinité »

Directory of Open Access Journals (Sweden)

Michèle Rosellini

2010-03-01

Full Text Available Nombre d’auteurs du xviie siècle représentatifs du libertinage ont été accusés de sodomie, au premier chef Théophile de Viau qui a été condamné au bûcher à la fois pour ce motif associé à l’athéisme. Aussi certains historiens de l’homosexualité les considèrent comme des victimes emblématiques de l’homophobie. Mais l’examen de leurs œuvres ne permet pas de conclure qu’ils expriment l’homosexualité au sens où nous l’entendons aujourd’hui. Un certain type de poésie représente, pour en faire l’apologie, des actes sodomitiques pratiqués indifféremment avec des partenaires masculins ou féminins. Leur but est la provocation morale et religieuse. Bénéficiant sans doute de la position sociale de leurs auteurs et de dispositifs de publication restreinte, ils incarnent l’esprit fort dans sa dimension transgressive. Dans un tout autre registre et dans un cadre élargi de publication, la poésie et la fiction peuvent valoriser les relations entre hommes comme un idéal de beauté et d’amour, en recourant à l’alibi de la philosophie de Platon et de la mythologie d’Ovide pour atténuer les représentations clairement sexuelles. Leurs auteurs parviennent néanmoins, par des moyens proprement poétiques et fictionnels, à donner expression au désir homosexuel. Celui-ci renforce alors la masculinité de l’esprit fort en l’associant à une fécondité intellectuelle et artistique capable de composer avec les normes de l’espace public.Some seventeenth-century libertine writers were accused of sodomy, most famously Theophile de Viau, who was condemned to be burned at the stake, for both atheism and sodomy. Some scholars of queer theory would like to present them primarily as victims of homophobia. But if we observe their works, we hardly find that they express homosexuality in its contemporary meaning and form. To adress this question of sexuality, we can distinguish two kinds of texts. Some of them

Coupling the Gaussian Free Fields with Free and with Zero Boundary Conditions via Common Level Lines

Science.gov (United States)

Qian, Wei; Werner, Wendelin

2018-06-01

We point out a new simple way to couple the Gaussian Free Field (GFF) with free boundary conditions in a two-dimensional domain with the GFF with zero boundary conditions in the same domain: Starting from the latter, one just has to sample at random all the signs of the height gaps on its boundary-touching zero-level lines (these signs are alternating for the zero-boundary GFF) in order to obtain a free boundary GFF. Constructions and couplings of the free boundary GFF and its level lines via soups of reflected Brownian loops and their clusters are also discussed. Such considerations show for instance that in a domain with an axis of symmetry, if one looks at the overlay of a single usual Conformal Loop Ensemble CLE3 with its own symmetric image, one obtains the CLE4-type collection of level lines of a GFF with mixed zero/free boundary conditions in the half-domain.

CT assessment of progression in pulmonary emphysema

Energy Technology Data Exchange (ETDEWEB)

Satoh, Katashi; Mitani, Masahiro [Kagawa Medical Univ., Miki (Japan); Murota, Makiko (and others)

2002-01-01

The purpose of this study was to assess the progression of pulmonary emphysema (PE) using CT. We reviewed the records of 25 cases (all male smokers and age range of 36-85 years) in whom progression of PE was recognized using CT scanning. PE was diagnosed by the presence of low attenuation areas on CT scan. PE was divided into 2 subtypes: centrilobular emphysema (CLE) and paraseptal emphysema (PSE). There were 8 younger cases less than 50s. With respect to smoking habit, 6 cases had 1 pack per day at maximum whereas the remaining 19 cases had more over than 1.5 packs per day. Interval periods of observation were from 8 months minimum to 10 years maximum. PE, of both CLE and PSE subtype, was recognized even in younger cases less than 40 years of age, and progressed with cigarette consumption even a minimum during 8 months periods of observation. (author)

L'univers quantique tout ce qui peut arriver arrive

CERN Document Server

Cox, Brian

2018-01-01

Brian Cox et Jeff Forshaw révèlent dans cet ouvrage la signification profonde de la physique quantique. Ils montrent pourquoi elle fournit une description de la Nature avec un immense pouvoir prédictif et explicatif, couvrant une vaste gamme de phénomènes, des puces de silicium aux fonctionnement des étoiles. L'histoire commence au tournant du XXe siècle, avec l'hypothèse de Max Planck qui postule que le rayonnement lumineux dégagé par un corps chaud est constituée de petits paquets d'énergie qu'il nomme "quanta". Brian Cox et Jeff Forshaw explorent ensuite plus d'un siècle de découvertes et de questionnements, jusqu'au fameux boson de higgs, clé de voûte du modèle standard décrivant la matière à son niveau le plus élémentaire.

Chimie et mécanisme dans la nouvelle Académie royale des sciences : les débats entre Louis Lémery et Etienne-François Geoffroy

Directory of Open Access Journals (Sweden)

Bernard Joly

2008-03-01

Full Text Available Au début du XVIIIe siècle, une querelle éclate entre deux chimistes français à propos de la fabrication artificielle du fer. C’est en fait un conflit entre une interprétation mécaniste des processus chimiques et une approche plus traditionnelle, soupçonnée d’emprunter ses thèses à l’alchimie, mais qui sera pourtant à l’origine de la table des affinités qui sera adoptée par tous les chimistes jusqu’au début du XIXe siècle.In the early eighteenth century a quarrel came out between two French chemists concerning artificial making of iron. It was in fact a conflict between a mechanist interpretation of chemical process and a more traditional approach, which was suspected of having taken his thesis from alchemy. But nevertheless, this approach will lead to affinity table which was accepted by all the chemists until the early nineteenth century.

Publications | Page 181 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Economic Liberalization and Political Violence : Utopia or Dystopia ? Un ouvrage essentiel pour quiconque souhaite comprendre les conflits et le développement au XXIe siècle. James Putzel, Crisis States Research Centre, London School of Economics. Alors que certains voient en la mondialisation un outil de ...

Publications | Page 186 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Economic Liberalization and Political Violence : Utopia or Dystopia ? Un ouvrage essentiel pour quiconque souhaite comprendre les conflits et le développement au XXIe siècle. James Putzel, Crisis States Research Centre, London School of Economics. Alors que certains voient en la mondialisation un outil de ...

Epidemiology of road traffic crashes among long distance drivers in ...

African Journals Online (AJOL)

Department of Epidemiology and Medical Statistics, Faculty of Public Health, University of Ibadan, Ibadan. 2. Anaesthetist, Emergency ... long-distance drivers studied. Reconstruction of bad roads and implementation of road safety education ... transport and occur on a traffic way or while the vehi- cle is still in motion after ...

40 CFR 721.6660 - Polymer of alkanepolyol and poly-alkyl-poly-iso-cyan-ato-car-bo-mo-no-cycle, acetone oxime...

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Polymer of alkanepolyol and poly-alkyl... Polymer of alkanepolyol and poly-alkyl-poly-iso-cyan-ato-car-bo-mo-no-cycle, acetone oxime-blocked... substance identified generically as a polymer of alkane-polyol and polyalkylpolyisocyanatocarbomonocy- cle...

A food plant specialist in Sparganothini? A new genus and species from Costa Rica (Lepidoptera: Tortricidae)

Science.gov (United States)

Sparganocosma docsturnerorum Brown, new genus and new species, is described and illustrated from Area de Conservación (ACG) in northwestern Costa Rica. The new genus shares a long, crescent- or ribbon-shaped signum in the corpus bursae of the female genitalia with Aesiocopa Zeller, 1877, Amorbia Cle...

J. B. S. Haldane and the origin of life

Indian Academy of Sciences (India)

STÉPHANE TIRARD

2017-11-24

Nov 24, 2017 ... François Viète Center for Epistemology and History of Science and Technology, University of Nantes, ... nature of life with a scenario of the origin of life on the ..... Histoire et philosophie des sciences à la fin du siècle (ed. J.-C.

Studies Related to the Oregon State University High Temperature Test Facility: Scaling, the Validation Matrix, and Similarities to the Modular High Temperature Gas-Cooled Reactor

Energy Technology Data Exchange (ETDEWEB)

Richard R. Schultz; Paul D. Bayless; Richard W. Johnson; William T. Taitano; James R. Wolf; Glenn E. McCreery

2010-09-01

The Oregon State University (OSU) High Temperature Test Facility (HTTF) is an integral experimental facility that will be constructed on the OSU campus in Corvallis, Oregon. The HTTF project was initiated, by the U.S. Nuclear Regulatory Commission (NRC), on September 5, 2008 as Task 4 of the 5 year High Temperature Gas Reactor Cooperative Agreement via NRC Contract 04-08-138. Until August, 2010, when a DOE contract was initiated to fund additional capabilities for the HTTF project, all of the funding support for the HTTF was provided by the NRC via their cooperative agreement. The U.S. Department of Energy (DOE) began their involvement with the HTTF project in late 2009 via the Next Generation Nuclear Plant project. Because the NRC interests in HTTF experiments were only centered on the depressurized conduction cooldown (DCC) scenario, NGNP involvement focused on expanding the experimental envelope of the HTTF to include steady-state operations and also the pressurized conduction cooldown (PCC). Since DOE has incorporated the HTTF as an ingredient in the NGNP thermal-fluids validation program, several important outcomes should be noted: 1. The reference prismatic reactor design, that serves as the basis for scaling the HTTF, became the modular high temperature gas-cooled reactor (MHTGR). The MHTGR has also been chosen as the reference design for all of the other NGNP thermal-fluid experiments. 2. The NGNP validation matrix is being planned using the same scaling strategy that has been implemented to design the HTTF, i.e., the hierarchical two-tiered scaling methodology developed by Zuber in 1991. Using this approach a preliminary validation matrix has been designed that integrates the HTTF experiments with the other experiments planned for the NGNP thermal-fluids verification and validation project. 3. Initial analyses showed that the inherent power capability of the OSU infrastructure, which only allowed a total operational facility power capability of 0.6 MW, is

Başarılı ve Başarısız Dördüncü Sınıf Okuyucularının Okuduğunu Anlama ve Özetleme Becerileri.

Directory of Open Access Journals (Sweden)

Zeynep Bahap Kudret

2016-12-01

Full Text Available Bu çalışmada okumada başarılı olan ve olmayan öğrencilerin okuduğunu anlama ve özetleme becerilerinin karşılaştırmalı olarak incelenmesi amaçlanmıştır. Çalışmada, öğrencilerin yazılı özetlerindeki biçimbirimbilgisi/sözdizimi [Ortalama Sözce Uzunlukları (OSU] ve sözcük dağarcıkları da [Farklı Sözcük Sayısı (FSÖZS] karşılaştırılmıştır. Ayrıca, okuduğunu anlama puanları, özetleme puanları, OSU ve FSÖZS arasındaki ilişkiler incelenmiştir. Bu amaçla, 122 başarılı ve 122 başarısız okuyucu olmak üzere, toplam 244 dördüncü sınıf öğrencisi araştırmaya katılmıştır. Bulgular, zayıf okuyucuların tüm soru türlerini yanıtlamada akranlarından daha başarısız olduklarını göstermiştir. Bununla birlikte, her iki gruptaki öğrencilerin de en çok ana düşünceyi bulma ile kişisel bilgi ve deneyimlerini kullanarak çıkarım yapma sorularında güçlük çektikleri belirlenmiştir. Zayıf okuyucuların özetlemenin tüm alt becerilerinde, ayrıca OSU ve FSÖZS ölçümlerinde akranlarından daha fazla güçlüğe sahip oldukları görülmüştür. Özetleme, biçimbirimbilgisi/sözdizimi (OSU ve sözcük dağarcığı (FSÖZS değişkenlerinin okuduğunu anlama üzerindeki etkisi incelendiğinde, biçimbirimbilgisi/sözdiziminin okuduğunu anlamayı en iyi yordayan değişken olduğu bulunmuştur. In this study, it was aimed to examine reading comprehension and summarizing skills of successful and unsuccessful students in reading comparatively. Their morphosyntax knowledge (Mean Length of UtteranceMLU and vocabulary knowledge (Different Words Used-DWU in their written summaries were also compared in the study. In addition, the relations between their reading comprehension scores, summarizing scores, MLU and DWU were examined. For this purpose, 122 successful and 122 unsuccessful readers, totally 244 fourth graders participated in the study. Findings showed that poor

De Pierre de Sainte-Lucie à Benoit Rigaud, les mutations lyonnaises du «Chevalier de la Croix» (1534, 1581

Directory of Open Access Journals (Sweden)

Anne Réach-Ngô

2015-07-01

Full Text Available Le Chevalier de la Croix constitue l’un des récits de chevalerie de la Bibliothèque de Troyes (Oudot, 1612 qui a été importé d’Espagne, via Lyon, sur la scène éditoriale française au XVIe siècle (Saint-Lucie, 1534, avant de paraître à Paris l’année qui suit (Janot, 1535. C’est également à Lyon, un demi- siècle plus tard, que l’ouvrage connaît une seconde jeunesse (Rigaud, 1581, rapidement prolongée par une nouvelle édition parisienne (Bonfons, 1584. L’examen des mutations éditoriales de l’œuvre tout au long du siècle, et l’analyse de ces deux vagues de publication, permet de mettre au jour l’évolution des relations de concurrence entre Paris et Lyon dans l’histoire éditoriale de l’œuvre. Le Chevalier de la Croix is one of the Troyes Library (Oudot, 1612 chivalric romances imported from Spain through Lyon onto the French publishing scene in the 16th century (Saint-Lucie, 1534, before its publication in Paris the following year (Janot, 1535. Half a century later, Lyon was also the place where the book had a second youth (Rigaud, 1581, which was soon to be extended through a new parisian publication (Bonfons, 1584. The examination of the book’s editorial transformations throughout the century, along with the analysis of those two waves of publication, enables to bring to light the evolution of the competitive relationship between Paris and Lyon in the editorial history of this work. 

Gastro-esophageal reflux disease symptoms and demographic factors as a pre-screening tool for Barrett's esophagus.

Science.gov (United States)

Liu, Xinxue; Wong, Angela; Kadri, Sudarshan R; Corovic, Andrej; O'Donovan, Maria; Lao-Sirieix, Pierre; Lovat, Laurence B; Burnham, Rodney W; Fitzgerald, Rebecca C

2014-01-01

Barrett's esophagus (BE) occurs as consequence of reflux and is a risk factor for esophageal adenocarcinoma. The current "gold-standard" for diagnosing BE is endoscopy which remains prohibitively expensive and impractical as a population screening tool. We aimed to develop a pre-screening tool to aid decision making for diagnostic referrals. A prospective (training) cohort of 1603 patients attending for endoscopy was used for identification of risk factors to develop a risk prediction model. Factors associated with BE in the univariate analysis were selected to develop prediction models that were validated in an independent, external cohort of 477 non-BE patients referred for endoscopy with symptoms of reflux or dyspepsia. Two prediction models were developed separately for columnar lined epithelium (CLE) of any length and using a stricter definition of intestinal metaplasia (IM) with segments ≥ 2 cm with areas under the ROC curves (AUC) of 0.72 (95%CI: 0.67-0.77) and 0.81 (95%CI: 0.76-0.86), respectively. The two prediction models included demographics (age, sex), symptoms (heartburn, acid reflux, chest pain, abdominal pain) and medication for "stomach" symptoms. These two models were validated in the independent cohort with AUCs of 0.61 (95%CI: 0.54-0.68) and 0.64 (95%CI: 0.52-0.77) for CLE and IM ≥ 2 cm, respectively. We have identified and validated two prediction models for CLE and IM ≥ 2 cm. Both models have fair prediction accuracies and can select out around 20% of individuals unlikely to benefit from investigation for Barrett's esophagus. Such prediction models have the potential to generate useful cost-savings for BE screening among the symptomatic population.

English Teachers’ Teaching Quality in Madrasah in Jakarta and Banten based on the Dynamic Model of Educational Effectiveness

Directory of Open Access Journals (Sweden)

Siti Nurul Azkiya

2016-02-01

Full Text Available Abstract This paper was intended to describe English teachers’ teaching quality in teaching reading comprehension and provide some reflection and suggestion on how teaching quality could be improved. The classroom factors of the dynamic model (orientation, structuring, questioning, modeling, application, assessment, time management, and making classroom as a learning environment [CLE] were used as a reference to conceptualize teaching quality. Classroom observation instrument was used to measure teaching quality of 59 English teachers in Madrasah Tsanawiyah in the provinces of Jakarta and Banten with a focus on reading comprehension. The findings showed that among the above eight factors, teachers rarely practiced orientation, structuring, modeling, and CLE. In addition, they did not provide enough application whereas a lot of time was spent for reading aloud and translating the text. Nevertheless, they started to raise questions and conduct assessment. With respect to questioning, however, the questions were limited to product questions, which did not promote critical thinking. Finally, the assessment method used was limited to questioning. Abstrak Tulisan ini bertujuan untuk menjelaskan kualitas guru Bahasa Inggris dalam mengajar reading comprehension dan memberikan rekomendasi strategi meningkatkan kualitas mengajar. Delapan aspek yang ada dalam the Ddynamic Model (orientation, structuring, questioning, modeling, application, assessment, time management, and making classroom as a learning environment [CLE] dijadikan sebagai pijakan untuk mendefinisikan konsep kualitas mengajar. Penelitian ini menggunakan instrumen observasi kelas untuk melihat bagaimana guru mengajar reading comprehension. Partisipan penelitian ini adalah 59 guru Bahasa Inggris di Madrasah Tsanawiyah di propinsi DKI Jakarta dan Banten. Temuan penelitian ini menunjukkan bahwa di antara delapan aspek kualitas mengajar yang dalam the Dynamic Model, kebanyakan guru jarang

Tracking tumor boundary in MV-EPID images without implanted markers: A feasibility study

International Nuclear Information System (INIS)

Zhang, Xiaoyong; Homma, Noriyasu; Ichiji, Kei; Takai, Yoshihiro; Yoshizawa, Makoto

2015-01-01

Purpose: To develop a markerless tracking algorithm to track the tumor boundary in megavoltage (MV)-electronic portal imaging device (EPID) images for image-guided radiation therapy. Methods: A level set method (LSM)-based algorithm is developed to track tumor boundary in EPID image sequences. Given an EPID image sequence, an initial curve is manually specified in the first frame. Driven by a region-scalable energy fitting function, the initial curve automatically evolves toward the tumor boundary and stops on the desired boundary while the energy function reaches its minimum. For the subsequent frames, the tracking algorithm updates the initial curve by using the tracking result in the previous frame and reuses the LSM to detect the tumor boundary in the subsequent frame so that the tracking processing can be continued without user intervention. The tracking algorithm is tested on three image datasets, including a 4-D phantom EPID image sequence, four digitally deformable phantom image sequences with different noise levels, and four clinical EPID image sequences acquired in lung cancer treatment. The tracking accuracy is evaluated based on two metrics: centroid localization error (CLE) and volume overlap index (VOI) between the tracking result and the ground truth. Results: For the 4-D phantom image sequence, the CLE is 0.23 ± 0.20 mm, and VOI is 95.6% ± 0.2%. For the digital phantom image sequences, the total CLE and VOI are 0.11 ± 0.08 mm and 96.7% ± 0.7%, respectively. In addition, for the clinical EPID image sequences, the proposed algorithm achieves 0.32 ± 0.77 mm in the CLE and 72.1% ± 5.5% in the VOI. These results demonstrate the effectiveness of the authors’ proposed method both in tumor localization and boundary tracking in EPID images. In addition, compared with two existing tracking algorithms, the proposed method achieves a higher accuracy in tumor localization. Conclusions: In this paper, the authors presented a feasibility study of tracking

Disease: H01207 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available zed by the premature closure of the metopic suture. It has been reported that mutations in FGFR1 and FREM1 c...LE ... Mild trigonocephaly and intracranial pressure: report of 56 patients. ... JOURNAL ... Childs Nerv Syst 20:749-56 (2004) DOI:10.1007/s00381-004-0970-y

Ténèbres khmères: les revenants de Phnom Penh : à propos de Kampuchéa de Patrick Deville

NARCIS (Netherlands)

van Montfrans, M.; Freyermuth, S.; Bonnot, J.-F.P.

2014-01-01

Remonter le Mékong comme Patrick Deville dans les traces de Henri Mouhot, paisible explorateur du XIXe siècle, naturaliste chasseur de papillons, semble une entreprise plus idyllique que de parcourir le monde contemporain comme l’a fait Jean Rolin pour une enquête sur les chiens errants. Ma

Histoire et sociétés du Vietnam classique

OpenAIRE

Papin, Philippe

2012-01-01

Programme de l’année 2008-2009 : I. Histoire rurale de la propriété foncière au Vietnam du XVIe au XVIIIe siècle. — II. Étude des sources de l’histoire villageoise du bassin du fleuve Rouge à l’époque moderne.

Learning Management Platform for CyberCIEGE

Science.gov (United States)

2011-12-01

CLE is a platform that allows academic and research collaboration and it is built on open pedagogy and open standard [16]. In those situations...C. Irvine, “Active learning with the CyberCIEGE video game,” in Proceedings of the 4th Conference on Cyber Security Experimentation and Test, 2011

Determination of the Partition Coefficients of Organophosphorus Compounds Using High-Performance Liquid Chromatography.

Science.gov (United States)

1987-12-01

have claimed an advantage to deter- mining values of k’ in 100% aqueous mobile phases by extrapolation of linear plots of log k’ vs. percent organic...im parti- cle size chemically bonded octadecylsilane (ODS) packing ( Alltech Econo- sphere). As required, this column was saturated with I-octanol by in

cDNA cloning, structural analysis, SNP detection and tissue ...

Indian Academy of Sciences (India)

THOMAS NAICY

detection and tissue expression profile of the IGF1 gene in Malabari and Attappady Black goats of India. J. Genet. ... Keywords. gene cloning; gene expression; goat; insulin-like growth factor 1; mRNA; single-nucleotide ..... cle tenderness (Koohmaraie et al. .... growth factor (IGF) system in the bovine oviduct at oestrus and.

Relatos cortos escritos por mujeres en el siglo XIX

Directory of Open Access Journals (Sweden)

Marta Giné

2014-04-01

Full Text Available A propósito de la obra editada por Concepción Palacios y Pedro Méndez, Femmes nouvellistes françaises du XIXesiècle(Berna, Peter Lang, coll. « Espacios literarios en contacto », vol. 4, 2013, 366 p. ISBN: 978-3-0343-1409-1.

Disease: H00869 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available (CLE) Leukoencephalopathy with vanishing white matter (VWM), also referred to as childhood ataxia with diffu...se central nervous system hypomyelination (CACH), is one of the most prevalent inherited child...rder usually begins in early childhood, but a wide spectrum of clinical severity is now recognized from fata

Synthesis, characterization, photoluminescence and thermally ...

Indian Academy of Sciences (India)

Administrator

X-ray diffraction and scanning electron microscopy to identify the crystalline phase and determine the parti- cle size. ... Spectral characteristics of the TSL glow showed emission around 565, 599 and. 641 nm, indicating ... thesis and characterization of rare-earth-doped ZnAl2O4 ..... Other researchers have reported similar.

Might video games help remedy childhood obesity?

Science.gov (United States)

Obesity is the most prevalent health problem among children in the United States and globally, leading to diverse health problems and staggering costs. Most child obesity prevention interventions are not working well, or not at all. Part of the problem is that the causes of child obesity are not cle...

75 FR 20528 - Proposed Amendment to Class B Airspace; Cleveland, OH

Science.gov (United States)

2010-04-20

..., SE., West Building Ground Floor, Room W12-140, Washington, DC 20590-0001; telephone: (202) 366-9826... and AIM, Federal Aviation Administration, 800 Independence Avenue, SW., Washington, DC 20591... extension to the southwest described from the 20-mile arc of the CLE Runway 24L ILS/DME antenna (I-HPI) to...

De l'honorable ennemi au compagnon de fortune From the respectable enemy to the one who shares a common destiny

Directory of Open Access Journals (Sweden)

Györgyi Mate

2012-05-01

Full Text Available Dans la culture hongroise, 150 ans de proche cohabitation avec l'Empire ottoman ont laissé d'innombrables traces. En littérature, la richesse relative en documents ne nous permet que de frôler la « question turque ». Nous proposons ici une récurrence fondamentale, l’honneur et tout particulièrement la parole donnée. Cette problématique peut être envisagée selon trois axes. Les engagements personnels – politiques et militaires – ; la question des conversions, recoupant le domaine de la religion ; le fonctionnement de la cohabitation, plus complexe. Les textes illustrant ces trois approches sont d'une grande diversité. Les mémoires d'esclave ou les chants épiques y tiennent une place égale avec le roman du XIXe siècle. L'image de l'Empire ottoman a subi une métamorphose considérable au cours des siècles en Hongrie. Au quinzième siècle, un des premiers témoignages européens présente un régime bien ordonné, dont les valeurs morales constituent un exemple à suivre pour la chrétienté. Vers le milieu du XVIe siècle, Hans Dernschwam ne trouve dans l'Empire que des « bizarreries ridicules et vicieuses ». Au même moment, les chansons de geste de Tinódi montrent le sultan Soliman en ennemi redouté des puissances occidentales. Un siècle plus tard, le poète Miklós Zrínyi sublime ce monarque en figure légendaire. Le XIXe siècle ouvre deux nouvelles voies : le romantisme de Jókai peint une âme profonde et orientale ; le réalisme de Tömörkény s’intéresse aux petites gens. Le XXe siècle exploite le sujet ottoman tout en hésitant entre l'image de l'ennemi séculaire, et celle d’une cohabitation paisible des deux peuples.The 150 years of the close cohabitation with the Ottoman Empire has certainly left numerous traces in the Hungarian culture. With regard to literature, the relative poorness of available documents does not allow us to even to venture in the road of the “Turkish question”. Here

La construction du temps chez les historiens universitaires français de la seconde moitié du XXe siècle The building of Time by French University historians during the second half of the XXe

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Jean Leduc

2009-06-01

Full Text Available Les historiens français de la seconde moitié du XXe siècle sont plus conscients que leurs prédécesseurs que le travail de recherche et d’écriture de l’histoire est une interaction continuelle entre présent et passé. La plupart d’entre eux ont substitué le présent au passé simple comme temps de base de la narration. Ils sont plus attentifs aux tendances et aux phénomènes de longue durée qu’au temps court des événements. Ils sont moins réticents à étudier le passé le plus récent mais, sur ce point, la controverse n’est pas close. Ouvertement ou non, le récit chronologique demeure le modèle de plan prédominant, de même que continue à prévaloir un système de datation absolue se référant au calendrier. Les historiens font attention à éviter les coupures chronologiques abusives et prennent soin de ne pas suggérer qu’une séquence d’événements implique nécessairement une relation causale entre eux. Les débats théoriques se développent mais, le plus souvent, résultent d’incitations extérieures au corps des historiens.French historians of the second half of the XXe century are more aware than their predecessors that historical research and writing means continuous interaction between past and present. Most of them have substituted the grammatical present for the preterit as the basic tense of the narrative. They pay more attention to trends and long-term phenomena than to short-term events. They are less reluctant to study the most recent past, but this issue remains controversial. Openly or not, chronological story is still the prevailing model, as is the absolute dating system according to the calendar. Historians are careful to avoid arbitrary chronological divisions and they stress that a sequence of events does not imply a relationship of cause and effect between them. Theorical discussions are on-going but, more often than not are the result of encouragement from outside the historical

Passages de frontières. Le voyage de la jeune mariée dans la haute noblesse des temps modernes (XVe-XVIIIe siècle

Directory of Open Access Journals (Sweden)

Christiane Coester

2012-06-01

Full Text Available Même si l’historiographie française a surtout retenu le voyage des infantes espagnoles vers le royaume de France et celui de Marie-Antoinette en 1770, les voyages nuptiaux vers la résidence du futur(e époux (se étaient en usage dans toute l’Europe du XVe au XVIIIe siècle. S’il n’existe à priori qu’un seul texte normatif (De institutione vivendi écrit par Diomeda Carafa en 1476, bien d’autres sources permettent d’étudier ces voyages sans retour (correspondances, récits de voyage, journaux et brochures, comptes princiers, etc.. Après avoir présenté une typologie de ces voyages nuptiaux, l’article se focalise sur le voyage le plus classique, celui qui conduit, à travers toute une série d’étapes codifiées, une jeune femme de la demeure parentale à celle de son époux. L’un des moments les plus importants de ce périple est sans nul doute le passage de la frontière car il s’accompagne de nombreuses représentations des différences culturelles réelles ou supposées tout en coïncidant avec le passage du statut de fille à celui d’épouse. À son arrivée à la cour de son époux, la fiancée se doit d’adopter les codes vestimentaires et les coiffures qui y sont à la mode, à la fois pour manifester sa volonté d’insertion mais aussi pour plaire à son mari. Les exemples de voyages nuptiaux étudiés à travers toute l’Europe manifestent finalement de nombreux points communs. Ce processus de transformation individuelle s’insère dans un autre plus vaste d’échange entre deux cours. Il ne s’agit pas seulement d’un déplacement dans l’espace mais aussi d’un changement de cadres des référents culturels (langue, mode, alimentation etc. souvent douloureux pour la jeune femme même s’il existe un certain nombre de cas d’intégration réussie, comme Anne d’Este ou encore Anne d’Autriche.While French historians have tended to focus on the nuptial trips of the Spanish infantes to the

A rare case of preputial calculi in a child with balanitis xerotica ...

African Journals Online (AJOL)

G.A. Kekre

2016-07-26

Jul 26, 2016 ... muscle power and has been bladder/bowel incontinent since his birth. The patient had not been ... pulse, low-grade fever, loss of mus- cle power in both lower limbs and bladder and bowel incontinence. ... fibrotic preputial skin with palpable hard nodular structures under- neath (Fig. 1). Continuous urine ...

Perceptions of Pre-Service Teachers on the Design of a Learning Environment Based on the Seven Principles of Good Practice

Science.gov (United States)

Al-Furaih, Suad Abdul Aziz

2017-01-01

This study explored the perceptions of 88 pre-service teachers on the design of a learning environment using the Seven Principles of Good Practice and its effect on participants' abilities to create their Cloud Learning Environment (CLE). In designing the learning environment, a conceptual model under the name 7 Principles and Integrated Learning…

P2Y2 and P2Y4 receptors regulate pancreatic Ca²+-activated K+ channels differently

DEFF Research Database (Denmark)

Klærke, Susanne Edeling Hede; Amstrup, Jan; Klærke, Dan Arne

2005-01-01

Extracellular ATP is an important regulator of transepithelial transport in a number of tissues. In pancreatic ducts, we have shown that ATP modulates epithelial K+ channels via purinergic receptors, most likely the P2Y2 and P2Y4 receptors, but the identity of the involved K+ channels was not cle...

L'ordre dans le chaos vers une approche déterministe de la turbulence

CERN Document Server

Bergé, Pierre; Vidal, Christian

1988-01-01

Depuis une trentaine d'années, l'irruption du non-linéaire conduit à une transformation en profondeur de l'ensemble de la physique, d'importance comparable aux deux révolutions, quantique et relativiste, qui ont marqué celle-ci à l'aube du vingtième siècle.

Evaluation of an interactive, case-based review session in teaching medical microbiology.

Science.gov (United States)

Blewett, Earl L; Kisamore, Jennifer L

2009-08-27

Oklahoma State University-Center for Health Sciences (OSU-CHS) has replaced its microbiology wet laboratory with a variety of tutorials including a case-based interactive session called Microbial Jeopardy!. The question remains whether the time spent by students and faculty in the interactive case-based tutorial is worthwhile? This study was designed to address this question by analyzing both student performance data and assessing students' perceptions regarding the tutorial. Both quantitative and qualitative data were used in the current study. Part One of the study involved assessing student performance using archival records of seven case-based exam questions used in the 2004, 2005, 2006, and 2007 OSU-CHS Medical Microbiology course. Two sample t-tests for proportions were used to test for significant differences related to tutorial usage. Part Two used both quantitative and qualitative means to assess student's perceptions of the Microbial Jeopardy! session. First, a retrospective survey was administered to students who were enrolled in Medical Microbiology in 2006 or 2007. Second, responses to open-ended items from the 2008 course evaluations were reviewed for comments regarding the Microbial Jeopardy! session. Both student performance and student perception data support continued use of the tutorials. Quantitative and qualitative data converge to suggest that students like and learn from the interactive, case-based session. The case-based tutorial appears to improve student performance on case-based exam questions. Additionally, students perceived the tutorial as helpful in preparing for exam questions and reviewing the course material. The time commitment for use of the case-based tutorial appears to be justified.

Adopting an Advanced Community Pharmacy Practice Experiential Educational Model Across Colleges of Pharmacy

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Jennifer L. Rodis

2011-01-01

Full Text Available Objective: To discuss the experience of sharing an experiential model of education and practice development between two colleges of pharmacy and to provide a framework to guide faculty in this type of collaboration. Case Study: The Ohio State University College of Pharmacy (OSU COP Partner for Promotion (PFP program was developed in response to the need for advancing practice in the community pharmacy setting. After successful implementation of this program, the PFP program design and materials were shared, adapted, and implemented at the University of Utah College of Pharmacy (Utah COP. Collaborating faculty developed a framework based on lessons learned through this experience which proposes key guiding strategies as considerations to address prior to embarking on sharing any aspect of an educational program or model between institutions. Each step of the framework is described and applied to the process followed by The OSU COP and Utah COP in sharing the PFP program. Additional considerations related to transfer of educational models are discussed. Results/Conclusion: Sharing the education model and materials associated with the PFP program between institutions has enhanced experiential opportunities for students and helped develop residency training sites in the community setting. In addition, the relationship between the two colleges has contributed to faculty development, as well as an increase in community pharmacy service development with community pharmacy partners at each institution. It is hoped this experience will help guide collaborations between other colleges of pharmacy to enhance education of future pharmacists while positively impacting pharmacy practice, teaching, and research by faculty.   Type: Case Study

Adopting an Advanced Community Pharmacy Practice Experiential Educational Model Across Colleges of Pharmacy

Directory of Open Access Journals (Sweden)

Jennifer L. Rodis, Pharm.D., BCPS

2011-01-01

Full Text Available Objective: To discuss the experience of sharing an experiential model of education and practice development between two colleges of pharmacy and to provide a framework to guide faculty in this type of collaboration.Case Study: The Ohio State University College of Pharmacy (OSU COP Partner for Promotion (PFP program was developed in response to the need for advancing practice in the community pharmacy setting. After successful implementation of this program, the PFP program design and materials were shared, adapted, and implemented at the University of Utah College of Pharmacy (Utah COP. Collaborating faculty developed a framework based on lessons learned through this experience which proposes key guiding strategies as considerations to address prior to embarking on sharing any aspect of an educational program or model between institutions. Each step of the framework is described and applied to the process followed by The OSU COP and Utah COP in sharing the PFP program. Additional considerations related to transfer of educational models are discussed.Results/Conclusion: Sharing the education model and materials associated with the PFP program between institutions has enhanced experiential opportunities for students and helped develop residency training sites in the community setting. In addition, the relationship between the two colleges has contributed to faculty development, as well as an increase in community pharmacy service development with community pharmacy partners at each institution. It is hoped this experience will help guide collaborations between other colleges of pharmacy to enhance education of future pharmacists while positively impacting pharmacy practice, teaching, and research by faculty.

Stochastic simulation of climate change impacts on ice road operations, MacKenzie River, Northwest Territories

International Nuclear Information System (INIS)

Woo, Mingko; Lonergan, S.

1990-01-01

Winter roads constitute an important part of the transportation network in the MacKenzie Delta, the Yellowknife area, and between the MacKenzie Highway and the Canol Road. Climatic changes in the MacKenzie Valley will alter the probabilities of ice cover thickness and duration, impacting on the periods when ice road river crossings are viable. Stochastic models were developed to generate air temperature and precipitation data to analyze climate impacts on when ice road crossing of the MacKenzie River at Norman Wells is feasible. The data were employed to simulate river ice growth and decay. Several general circulation models were employed to determine the impacts of climatic change on the ice regime. For precipitation simulation, the occurrence of wet or dry days was determined from Markov chain transition probabilities. In general, the Goddard Institute of Space Studies (GISS) model predicted the largest increase in monthly precipitation and the Oregon State University (OSU) model predicted the least changes. The various scenarios indicated that the duration for vehicular traffic over ice will be significantly reduced, compared to present day Norman Wells ice crossing operation. For 20 tonne vehicles, the current duration for safe crossing averages 169±14.6 days per year, while for the OSU scenario it will be reduced to 148±14.7 days, is further reduced to 127±24.9 days for the GISS scenario, and drops to 122±21.7 days for the GFDL (General Fluid Dynamics Laboratory) scenario. 5 refs., 1 fig

Evaluation of early and late complications in patients with congenital lobar emphysema: A 12 year experience

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Nazem Masood

2010-01-01

Full Text Available Background: Congenital lobar emphysema (CLE is characterised by over distension of one lobe and pressure on the adjacent lobe and mediastinum. In this study, we review the pathological results of our paediatric patients with CLE, highlighting the early and late complications that occurred in these patients. Patients and Methods: In a prospective study from 1996 to 2008, we evaluated 30 patients with CLE diagnosis. Variables collected included sex, age at the time of diagnosis, radiological diagnostic method, type of treatment, pathological analysis, surgical findings and early postoperative complications. Parents were asked to refer to our clinic for follow-up and evaluation of late complications. Results: Thirty patients and males accounted for majority of the study population (n = 20, 67%. The mean age of male and female patients (at admission was 7.2 ± 2.3 and 4.7 ± 1.2 months respectively (P = not significant. The main diagnostic method was chest x-ray (CXR in all patients. Abnormal bronchial cartilage was found in 71% of patients. The most affected lobe was left upper lobe (50%. Associated anomalies were seen in four patients. Early postoperative periodhadtwo cases of pneumothoraces. At six month follow up, five (25% males and four females (40% had delayed weight gain. Permanent oxygen dependency was seen in two patients. Twenty- six patients underwent thoracotomy. Mortality rate was 13%. Base deficit at the time of admission was greater in those patients who eventually died, (-8.6 ± 1.2 versus -3.1 ± 0.4 (P = 0.0003. There were two deaths in the bilobar involvement group and two in the unilobar involvement group (P = 0.07, near significant. Conclusion: This study confirms that the number of affected lobes and base deficit at the time of admission were associated with significantly increased mortality.

De Créuse à Médée (selon le Peintre de Darius

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Françoise-Hélène Massa-Pairault

2016-07-01

Full Text Available Les héroïnes de tragédies ont un statut spécial dans le monde figuré du Peintre de Darius.  C’est le cas de Médée et de Créuse (mère d’Ion auxquelles le céramographe apulien réserve de véritables « épiphanies ». Pour quels motifs et quel est le lien entre deux héroïnes apparemment bien différentes ? L’ A. procède à un réexamen critique d’iconographies célèbres, valorisant certains détails, souvent négligés, dont la compréhension est essentielle. Le P. de Darius conçoit le lien entre ses héroïnes à travers sa connaissance des auteurs tragiques athéniens du Ve siècle, principalement d’Euripide. Or, comment et pourquoi les problèmes affrontés par Médée et Créuse, reflétant le contexte politique et social de l’Athènes classique, sont-ils susceptibles d’intéresser le public de l’artiste apulien, formé de citoyens de poleis italiotes (notamment Tarente ou par des représentants de communautés non grecques (notamment dauniennes ou peucétiennes ? L’A. esquisse aussi une réponse à ces questions en examinant les motifs guidant le Peintre de Darius lorsqu’il transpose et réactualise les débats de la polis athénienne du Ve siècle dans le contexte politique, géo-politique et social de la Grande Grèce du IVe siècle.

JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases.

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Ana Karina Alves de Medeiros

Full Text Available The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs. JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia areata. Patients suffering from other ISDs might also benefit from JAK inhibition. Given the development of specific JAK inhibitors, the expression patterns of JAKs in different ISDs needs to be clarified. We aimed to analyze the expression of JAK/STAT family members in a set of prevalent ISDs: psoriasis, lichen planus (LP, cutaneous lupus erythematosus (CLE, atopic dermatitis (AD, pyoderma gangrenosum (PG and alopecia areata (AA versus healthy controls for (pJAK1, (pJAK2, (pJAK3, (pTYK2, pSTAT1, pSTAT2 and pSTAT3. The epidermis carried in all ISDs, except for CLE, a strong JAK3 signature. The dermal infiltrate showed a more diverse expression pattern. JAK1, JAK2 and JAK3 were significantly overexpressed in PG and AD suggesting the need for pan-JAK inhibitors. In contrast, psoriasis and LP showed only JAK1 and JAK3 upregulation, while AA and CLE were characterized by a single dermal JAK signal (pJAK3 and pJAK1, respectively. This indicates that the latter diseases may benefit from more targeted JAK inhibitors. Our in vitro keratinocyte psoriasis model displayed reversal of the psoriatic JAK profile following tofacitinib treatment. This direct interaction with keratinocytes may decrease the need for deep skin penetration of topical JAK inhibitors in order to exert its effects on dermal immune cells. In conclusion, these results point to the important contribution of the JAK/STAT pathway in several ISDs. Considering the epidermal JAK3 expression levels, great interest should go to the investigation of topical JAK3 inhibitors as therapeutic option of ISDs.