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Sample records for opis dwoch przypadkow

  1. Pollen Contents Of Commercial Honeys Of Opi, Nsukka, Enugu ...

    African Journals Online (AJOL)

    Pollen Contents Of Commercial Honeys Of Opi, Nsukka, Enugu State, Nigeria. ... Abstract. Pollen analyses of seven honey samples from Opi-Nsukka Mini market were evaluated for their pollen composition. The results ... HOW TO USE AJOL.

  2. The structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo NAD(+) content in OPI-induced teratogenesis in chickens.

    Science.gov (United States)

    Seifert, Josef

    2016-05-01

    The objective of this study was to determine the structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo nicotinamide adenine dinucleotide (NAD(+)) content in OPI-induced teratogenesis and compare them with those needed for OPI inhibition of yolk sac membrane kynurenine formamidase (KFase), the proposed primary target for OPI teratogens in chicken embryos. The comparative molecular field analysis (COMFA) of three-dimensional quantitative structure-activity relationship (3D QSAR) revealed the electrostatic and steric fields as good predictors of OPI structural requirements to reduce NAD(+) content in chicken embryos. The dominant electrostatic interactions were localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and at the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-6 of the pyrimidinyls and/or N-substituents of crotonamides was the steric structural component that contributed to superiority of those OPI for reducing embryonic NAD(+) levels. Both electrostatic and steric requirements are similar to those defined in our previous study for OPI inhibition of chicken embryo yolk sac membrane KFase. The findings of this study provide another piece of evidence for the cause-and-effect relationship between yolk sac membrane KFase inhibition and reduced embryo NAD(+) content in NAD-associated OPI-induced teratogenesis in chickens. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Beware the obsequious physician executive (OPIE but embrace dyad leadership

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2017-10-01

    Full Text Available No abstract available. Article truncated after 150 words. Obsequious is defined as “obedient or attentive to an excessive or servile degree”. Obsequious comes from the Latin root sequi, meaning "to follow”. An Obsequious PhysIcian Executive (OPIE is more likely to be servile to the hospital administration than a leader of the medical staff. This is not surprising since they are chosen for “leadership” position not by the physicians they purportedly lead, but by the hospital administration they serve. OPIEs become the administration’s representative to the physicians and not the physicians’ or patients’ representative to the administration. Their job often becomes keeping the medical staff “in-line” rather than putting the success of the medical center first. My own views have developed over 40 years of observing OPIE behavior in a multitude of medical centers. Although there are many exceptions, OPIEs often share certain characteristics: 1. Academic failure. OPIEs are usually academic failures. They are the antithesis of the triple …

  4. Architecture and Functionality of the Advanced Life Support On-Line Project Information System (OPIS)

    Science.gov (United States)

    Hogan, John A.; Levri, Julie A.; Morrow, Rich; Cavazzoni, Jim; Rodriquez, Luis F.; Riano, Rebecca; Whitaker, Dawn R.

    2004-01-01

    An ongoing effort is underway at NASA Amcs Research Center (ARC) tu develop an On-line Project Information System (OPIS) for the Advanced Life Support (ALS) Program. The objective of this three-year project is to develop, test, revise and deploy OPIS to enhance the quality of decision-making metrics and attainment of Program goals through improved knowledge sharing. OPIS will centrally locate detailed project information solicited from investigators on an annual basis and make it readily accessible by the ALS Community via a web-accessible interface. The data will be stored in an object-oriented relational database (created in MySQL(Trademark) located on a secure server at NASA ARC. OPE will simultaneously serve several functions, including being an R&TD status information hub that can potentially serve as the primary annual reporting mechanism. Using OPIS, ALS managers and element leads will be able to carry out informed research and technology development investment decisions, and allow analysts to perform accurate systems evaluations. Additionally, the range and specificity of information solicited will serve to educate technology developers of programmatic needs. OPIS will collect comprehensive information from all ALS projects as well as highly detailed information specific to technology development in each ALS area (Waste, Water, Air, Biomass, Food, Thermal, and Control). Because the scope of needed information can vary dramatically between areas, element-specific technology information is being compiled with the aid of multiple specialized working groups. This paper presents the current development status in terms of the architecture and functionality of OPIS. Possible implementation approaches for OPIS are also discussed.

  5. Twardzina ograniczona pęcherzowa – opis przypadku

    Directory of Open Access Journals (Sweden)

    Elżbieta Meszyńska

    2011-01-01

    Full Text Available Wprowadzenie: Pęcherze pojawiające się w obrębie zmian typu twardzinyograniczonej są rzadko opisywane. Etiologia ich powstawaniajest wieloczynnikowa. Najczęściej rozważany jest ucisk blaszek twardzinowychna naczynia limfatyczne. Twardzina pęcherzowa wymagaróżnicowania z liszajem twardzinowym i zanikowym, w którym u częścichorych obserwuje się występowanie pęcherzy. Cel pracy: Przedstawienie przypadku 41-letniej kobiety z twardzinąograniczoną (morphea, u której w 15. roku trwania choroby wystąpiłypęcherze w obrębie ognisk twardzinowych. Opis przypadku: U 41-letniej kobiety z trwającymi od 15 lat ogniskamimorphea wystąpiły nadżerki oraz pęcherze krwotoczne w obrębieognisk stwardniałych. Badanie histopatologiczne wykazało obrzękskóry właściwej oraz obecność pęcherzy podnaskórkowych. Badaniaimmunologiczne (metoda immunofluorescencji pośredniej i bezpośredniejbyły negatywne. Obraz kliniczny i histopatologiczny pozwoliłna rozpoznanie odmiany pęcherzowej twardziny ograniczonej (morpheabullosa. Zmiany pęcherzowe ustąpiły po 40 dniach leczeniacefalosporynami (cefuroksym. Wnioski: Morphea bullosa jest rzadką odmianą twardziny skórnej, którawymaga różnicowania z liszajem twardzinowym i zanikowym orazautoimmunologicznymi, podnaskórkowymi chorobami pęcherzowymi.Wykwity pęcherzowe w obrębie ognisk morphea mogą wystąpićnawet po wielu latach utrzymywania się typowych blaszek stwardnieniowych.

  6. Embryo yolk sac membrane kynurenine formamidase of l-tryptophan to NAD+ pathway as a primary target for organophosphorus insecticides (OPI) in OPI-induced NAD-associated avian teratogenesis.

    Science.gov (United States)

    Seifert, Josef

    2017-10-01

    The objective of this study was to provide in ovo evidence for the proposed role of kynurenine formamidase of l-tryptophan to NAD + pathway in embryo yolk sac membranes as a primary target for organophosphorus insecticide (OPI) teratogens in OPI-induced NAD-associated avian teratogenesis. Slices prepared from yolk sac membranes or embryo livers of chicken eggs treated with the OPI dicrotophos and/or methyl parathion were incubated with l-tryptophan. Yolk sac membrane slices metabolized l-tryptophan in the pathway to NAD + before that function was established in livers. OPI interfered in ovo with the second step of l-tryptophan to NAD + biosynthesis by inhibiting kynurenine formamidase. Its inhibition due to the teratogen dicrotophos occurred in yolk sac membranes during the period of embryo highest susceptibility to OPI teratogens in contrast to delayed and lower inhibition caused by the nonteratogen methyl parathion. Both OPI affected liver kynurenine formamidase in a similar manner. The onsets of liver enzyme inhibition, however, were delayed by about two days and occurred at the time of the reduced embryo susceptibility to teratogens. The early disruption of l-tryptophan metabolism and higher inhibition of kynurenine formamidase in yolk sac membranes may be the factors that determine action of OPI as teratogens in chicken embryos. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Underpricing y subvaluación en las OPI de Perú y Chile

    OpenAIRE

    Zavala Rocha, Dorita Cristina; Freire Figueroa, Guillermo Pedro; Venero Di Baja, Ian Carlo

    2015-01-01

    El fenómeno del underpricing en la oferta pública inicial (OPI) se viene estudiando hace ya varias décadas, y se refiere al retorno positivo del primer día de la acción, calculado como la diferencia entre el precio de cierre del primer día de cotización y el precio de emisión pactado entre el emisor y el banco de inversión. Por otro lado, también existe el overpricing, es decir, al fenómeno que sucede cuando el precio de cierre del primer día de negociaciones es menor que el precio de oferta....

  8. Nawracające obwodowe porażenie nerwu twarzowego – opis przypadku

    Directory of Open Access Journals (Sweden)

    Małgorzata Figlus

    2014-07-01

    Full Text Available Zespół Melkerssona–Rosenthala jest klasycznie definiowany jako triada objawów pod postacią nawracającego obwodowego porażenia nerwu twarzowego, obrzęku w obrębie twarzy oraz języka pofałdowanego. Etiologia choroby nie została jednoznacznie potwierdzona – prawdopodobnie jest wieloczynnikowa, z dominującym mechanizmem reakcji autoimmunologicznej o typie nadwrażliwości późnej. Istotny może być także wpływ infekcji, chorób ogólnoustrojowych oraz urazów. Nie wyklucza się również predyspozycji genetycznej. Postaci pełnoobjawowe są rzadkie, a przypadki niepełnoobjawowe stanowią problem zarówno diagnostyczny, jak i terapeutyczny, mimo coraz liczniejszych opisów przypadków klinicznych. W artykule zaprezentowano przypadek pacjenta z nawracającym porażeniem nerwu twarzowego i językiem pofałdowanym, u którego rozpoznanie ustalono po 18 latach od wystąpienia pierwszego objawu choroby. Po przeprowadzeniu diagnostyki różnicowej zdiagnozowano niepełny zespół Melkerssona–Rosenthala i włączono standardowe leczenie, nie uzyskując jednak satysfakcjonujących efektów terapeutycznych. W pracy zwracamy uwagę na heterogenny obraz kliniczny pacjentów, wynikający z kolejnego pojawiania się objawów, na różnorodne podejścia terapeutyczne, brak jednoznacznych wytycznych co do strategii leczenia oraz potrzebę współpracy lekarzy różnych specjalności w celu ustalenia tego rzadkiego rozpoznania.

  9. Zakażenia pałeczkami Legionella pneumophila – opis przypadku

    Directory of Open Access Journals (Sweden)

    Bolesław Kalicki

    2011-12-01

    Full Text Available Legionella pneumophila jest wewnątrzkomórkowym patogenem zasiedlającym środowiska wodne. Do zakażenia dochodzi drogą inhalacji zakażonego aerozolu, rzadziej poprzez aspirację. Rozprzestrzenianie się zachodzi drogą krwionośną, limfatyczną i przez ciągłość. Choroba rozwija się w postaci dwóch klinicznie odrębnych zespołów: choroby legionistów i gorączki Pontiac. Pozapłucne postaci legionelozy spotyka się niezmiernie rzadko. Powikłania mogą występować w postaci niedodmy, wysięku, zrostów, ropni płuc, ropniaków opłucnej, przetok oskrzelowo-opłucnowych, a w konsekwencji mogą prowadzić do niewydolności wielonarządowej. W diagnostyce zakażenia Legionella pneumophila stosuje się izolację i hodowlę bakterii uzyskanych z tkanek chorego na specjalnych podłożach, metody genetyczne bądź też testy serologiczne. W leczeniu skuteczne są antybiotyki z grupy makrolidów, a w ciężkiej postaci choroby także fluorochinolony. Leczeniem alternatywnym jest kombinacja trimetoprym + sulfametoksazol. W artykule przedstawiono opis przypadku 14-letniego chłopca, który został przyjęty do Kliniki z powodu gorączki, osłabienia, wymiotów, bólów brzucha i głowy. U dziecka wykonano serię badań wyjaśniających przyczynę dolegliwości. Stwierdzono podwyższone wykładniki stanu zapalnego z towarzyszącą leukopenią i trombocytopenią. W przebiegu choroby pojawiły się kaszel i wysypka. W badaniach dodatkowych wysunięto podejrzenie zajęcia układu sercowo-naczyniowego. Podejrzewając zakażenie atypowe, do leczenia dołączono makrolid, po którym uzyskano poprawę stanu klinicznego i ustąpienie objawów. Otrzymany później wynik badania w kierunku Legionella pneumophila wskazywał na możliwość zakażenia o tej etiologii.

  10. Udar mózgu u 15‑letniej dziewczynki – opis przypadku

    Directory of Open Access Journals (Sweden)

    Anna Maślany

    2012-04-01

    Full Text Available Udary mózgu należą do najczęstszych schorzeń populacji dorosłych, ale mogą występować również u dzieci. Wyróżniamy udary niedokrwienne, wynikające z okluzji naczynia, oraz krwotoczne, gdy dochodzi do pęknię‑ cia ściany naczynia. Przyczyny udarów i czynniki ryzyka są inne niż u dorosłych, jednak aż w połowie przy‑ padków nie udaje się ich ustalić. Najczęstszą przyczyną w tej grupie wiekowej są wrodzone wady serca i ukła‑ du krążenia. Inne istotne czynniki ryzyka to zaburzenia układu krzepnięcia, nabyte choroby serca, dysplazje naczyniowe, autoimmunologiczne zapalenia naczyń, a także zakażenia, urazy i zaburzenia metaboliczne. Objawy choroby w grupie pediatrycznej są często niespecyficzne i słabo wyrażone, stąd mogą stanowić pro‑ blem diagnostyczny. W pracy umówiono współczesne metody diagnostyczne, zarówno obrazowe, jak i labo‑ ratoryjne, a także rekomendacje postępowania leczniczego, które aktualnie opierają się na wytycznych opra‑ cowanych na populacji dorosłych. W artykule przedstawiono również opis przypadku 15‑letniej dziewczynki z zaburzeniami świadomości, u której w badaniu rezonansu magnetycznego głowy stwierdzono ognisko nie‑ dokrwienne w prawej okolicy czołowo‑skroniowej. W toku diagnostycznym rozpoznano u pacjentki wadę serca pod postacią ubytku przedsionkowo‑komorowego typu II (ASD II, przetrwały otwór owalny (PFO oraz tęt‑ niak przegrody międzyprzedsionkowej. Badania psychologiczne przeprowadzone po incydencie wykazały zaburzenia koncentracji, pogorszenie jakości pisma, rozumienia, zapamiętywania oraz pogorszenie ogólnej sprawności psychomotorycznej.

  11. Pęknięcie śledziony po badaniu kolonoskopowym – opis przypadku

    Directory of Open Access Journals (Sweden)

    Dariusz Serwin

    2012-07-01

    Full Text Available Wprowadzenie: Kolonoskopia jest rutynowo wykonywanym badaniem w diagnostyce i profilaktyce chorób jelita grubego. Pęknięcie śledziony to rzadko odnotowywane powikłanie, dotychczas opisano 80 przypadków. Opis przypadku: Pacjent, lat 72, hospitalizowany z powodu niedokrwistości mikrocytarnej. W trakcie bada‑ nia kolonoskopowego wykonano polipektomię polipa esicy. W drugiej dobie po zabiegu: poranne omdlenie przy próbie pionizacji, utrzymująca się hipotonia, dodatnie objawy otrzewnowe. W badaniach dodatkowych: RTG przeglądowe jamy brzusznej – bez zmian, USG jamy brzusznej – płyn w jamie otrzewnej, powiększona śledziona o nierównych obrysach. W KT jamy brzusznej – rozerwanie śledziony z rozległym krwiakiem, duża ilość krwi w jamie otrzewnej. Pacjenta zakwalifikowano do laparotomii zwiadowczej, w wyniku której stwier‑ dzono: znaczna ilość płynnej krwi i skrzepów w jamie otrzewnej, śledziona z linijnym pęknięciem przy szypule, wątroba z pękniętą torebką oraz niewielkim uszkodzeniem miąższu i krwawieniem, na przedniej ścianie żołądka krwiak z niewielkim uszkodzeniem surowicówki, krezka okrężnicy – w pobliżu zagięcia śledzionowego krwiak, nie ujawniono perforacji jelita. Omówienie: Pęknięcie śledziony jest bardzo rzadkim, ale groźnym powikłaniem kolonoskopii. Wśród mechanizmów prowadzących do uszkodzenia śledziony wymienia się: bez‑ pośredni uraz, pociąganie układu więzadłowego, pociąganie zrostów między śledzioną i okrężnicą. Pęknięcie śledziony może być natychmiastowe lub opóźnione. Początek objawów występuje od 1 godziny do 2,5 dnia, najczęściej do 24 godzin od wykonania kolonoskopii. Czas do ustalenia rozpoznania – od 2 godzin do 13 dni, najczęściej do 24‑48 godzin. Najczęściej stosowane metody ustalenia rozpoznania to KT jamy brzusznej i USG jamy brzusznej. Śmiertelność wskutek pęknięcia śledziony po kolonoskopii – opisano 2 przypadki

  12. Opióides no manejo da dor - uso correto ou subestimado? Dados de um hospital universitário

    Directory of Open Access Journals (Sweden)

    Daudt A.W.

    1998-01-01

    Full Text Available OBJETIVO: O uso de opióides, principalmente no tratamento da dor intensa aguda (pacientes no pós-operatório e da dor crônica em pacientes oncológicos, tem sido subestimado na prática clínica em geral. Este trabalho tem o objetivo de verificar o perfil de prescrição de opióides (meperidina e morfina no Hospital de Clínicas de Porto Alegre (HCPA, RS. MATERIAIS E MÉTODOS: Análise da conduta das equipes médicas, pela revisão de 1.107 prescrições, relativas a 445 pacientes internados no HCPA, entre 20 de maio e 20 de julho de 1993. Os parâmetros básicos de análise, para conduta, incluíam: padrão de uso, a dose do fármaco, intervalo entre doses e analgésicos simultâneos. DISCUSSÃO E RESULTADOS: Foram encontradas apenas 6,5% de prescrições consideradas adequadas em relação aos parâmetros dose, intervalo e padrão, analisados conjuntamente. O padrão se necessário foi responsável por 74% do total de prescrições. CONCLUSÕES: Os resultados obtidos durante a realização do trabalho permitem-nos concluir que não há um manejo adequado da dor, tanto aguda como crônica, nos pacientes internados no HCPA.

  13. Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.

    Science.gov (United States)

    Gaspar, Maria L; Chang, Yu-Fang; Jesch, Stephen A; Aregullin, Manuel; Henry, Susan A

    2017-11-10

    In the yeast Saccharomyces cerevisiae , the Opi1p repressor controls the expression of INO1 via the Opi1p/Ino2p-Ino4p regulatory circuit. Inositol depletion favors Opi1p interaction with both Scs2p and phosphatidic acid at the endoplasmic reticulum (ER) membrane. Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p ( scs2 Δ) and a mutant, OPI1FFAT , lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Loss of the Opi1p-Scs2p interaction reduced INO1 expression and conferred inositol auxotrophy. Moreover, inositol depletion in strains lacking this interaction resulted in Opi1p being localized to sites of lipid droplet formation, coincident with increased synthesis of triacylglycerol. Supplementation of choline to inositol-depleted growth medium led to decreased TAG synthesis in all three strains. However, in strains lacking the Opi1p-Scs2p interaction, Opi1p remained in the nucleus, preventing expression of INO1 These data support the conclusion that a specific pool of phosphatidic acid, associated with lipid droplet formation in the perinuclear ER, is responsible for the initial rapid exit of Opi1p from the nucleus to the ER and is required for INO1 expression in the presence of choline. Moreover, the mitochondria-specific phospholipid, cardiolipin, was significantly reduced in both strains compromised for Opi1p-Scs2p interaction, indicating that this interaction is required for the transfer of phosphatidic acid from the ER to the mitochondria for cardiolipin synthesis. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. Epidural hematoma in the pediatric population – case study = Krwiak nadtwardówkowy w populacji pediatrycznej - opis przypadku

    Directory of Open Access Journals (Sweden)

    Kamila Woźniak

    2015-08-01

        Streszczenie Urazy głowy są głównymi przyczynami zgonu i nabytych zaburzeń neurologicznych. Odmienny niż u dorosłych przebieg urazu głowy w populacji dziecięcej powoduje, że w tej grupie zdarza się najwięcej nieoczekiwanych powikłań. Z uwagi na brak specyficznych objawów klinicznych krwiak nadtwardówkowy w populacji pediatrycznej stanowi duże wyzwanie zarówno diagnostyczne jak i lecznicze. Autorzy przedstawiają opis przypadku i postępowania u 6- letniego dziecka po urazie głowy,  z rozpoznanym w badaniu obrazowym krwiakiem nadtwardówkowym.   Słowa kluczowe: uraz czaszkowo-mózgowy, krwiak nadtwardówkowy, populacja pediatryczna.   Abstract Head injuries are the main causes of death and acquired neurological disorders. Differently than adults mileage head injury in the pediatric population means that in this group it happens most unexpected complications. Given the lack of specific clinical symptoms epidural hematoma in the pediatric population is a major challenge for both diagnostic and therapeutic. The authors present a case and proceedings in a child 6 years old after a head injury diagnosed in the study imaging epidural hematoma.   Key words: cephalo-cerebral trauma, epidural hematoma, pediatric population.

  15. Czaszkogardlak – rzadki łagodny guz nowotworowy - opis przypadku = Craniopharyngioma – rare benign tumor – case report

    Directory of Open Access Journals (Sweden)

    Kamila Woźniak

    2016-08-01

    • 2.        Katedra i Klinika Rehabilitacji, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu     Streszczenie Czaszkogardlak (guz Erdheima, łac. craniopharyngioma to stosunkowo rzadki, łagodny guz nowotworowy o lokalizacji wewnątrzczaszkowej, wywodzący się z pozostałości kieszonki Rathkego. Nazwę craniopharyngioma wprowadził Harvey Cushing w 1932. Jedne z pierwszych prób operacyjnego leczenia guza podjął Ludvig Puusepp w 1923 roku. Objawy kliniczne zależą od lokalizacji guza. Są to przede wszystkim objawy wynikające z ucisku masy guza na sąsiadujące struktury anatomiczne. Autorzy przedstawiają opis przypadku klinicznego, leczonego operacyjnie w Klinice Neurochirurgii, Neurotraumatologii i Neurochirurgii Dziecięcej Szpitala Uniwersyteckiego nr 1 im. dr A. Jurasza w Bydgoszczy z rozpoznanym w badaniu histopatologicznym craniopharyngioma.   Słowa kluczowe: czaszkogardlak, craniopharyngioma, guz Erdheima, nowotwór łagodny.     Abstract Craniopharyngioma (Erdheima tumor is a relatively rare benign tumor of intracranial location, derived from the remnants of Rathke's pouch. The name craniopharyngioma introduced Harvey Cushing in 1932. One of the first attempts at surgical treatment of the tumor took Ludvig Puusepp in 1923. Clinical symptoms depend on the site of a tumor. These are primarily the symptoms resulting from the comppression of the tumor mass on adjacent anatomical structures. The authors present a clinical case operating treated in the Department of Neurosurgery, Neurotraumatology and Pediatric Neurosurgery, Dr Antoni Jurasz University Hospital No.1 in Bydgoszcz histopathological diagnosed with craniopharyngoma.   Key words: craniopharyngioma, Erdheima tumor, benign tumor.

  16. Olbrzymi brodawczak splotu naczyniówkowego – opis przypadku = Giant choroid plexus papilloma – case report

    Directory of Open Access Journals (Sweden)

    Kamila Woźniak

    2016-08-01

    Kamila Woźniak1, Dorota Ratuszek-Sadowska2, Agnieszka Nowacka1, Maciej Śniegocki1    1.        Klinika Neurochirurgii, Neurotraumatologii i Neurochirurgii Dziecięcej, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu 2.        Katedra i Klinika Rehabilitacji, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu       Streszczenie   Brodawczak splotu naczyniówkowego (ang. choroid plexus papilloma to rzadki nowotwór ośrodkowego układu nerwowego, wywodzący się z nabłonka splotu naczyniówkowego układu komorowego mózgowia. W 50% przypadków rozwija się w komorze bocznej, w 40% w komorze IV i w 5% w komorze III. Guzy splotu naczyniówkowego występują przede wszystkim w 1. dekadzie życia. Guz produkuje płyn mózgowo - rdzeniowy, co przyczynia się do wodogłowia i nadciśnienia śródczaszkowego. Histologicznie zbudowany jest ze struktur brodawkowatych, utworzonych przez cylindrycznego kształtu komórki spoczywające na błonie podstawnej. Autorzy przedstawiają opis przypadku klinicznego chorej leczonej operacyjnie w Klinice Neurochirurgii, Neurotraumatologii i Neurochirurgii Dziecięcej Szpitala Uniwersyteckiego nr 1 im. dr A. Jurasza w Bydgoszczy z rozpoznanym w badaniu histopatologicznym brodawczakiem splotu naczyniówkowego.   Słowa kluczowe: brodawczak splotu naczyniówkowego, nowotwór, ośrodkowy układ nerwowy, neurochirurgia.   Abstract   Choroid plexus papilloma is a rare cancer of the central nervous system, derived from epithelial cells of the choroid plexus of the ventricular system of the brain. In 50% of cases resolve the side chamber, and in 40% in the fourth chamber and 5% in the third ventricle. Choroid plexus tumors occur primarily in the first decade of life. The tumor produces cerebrospinal fluid, which contributes to hydrocephalus and brain edema. Histologically is built with papillary structures formed by the

  17. Diagnostyczna funkcja arteterapii na oddziale psychiatrycznym dla młodzieży – opis przypadku

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    Agnieszka Gmitrowicz

    2012-09-01

    Full Text Available Opis przypadku klinicznego dotyczy analizy dynamiki obrazu psychopatologicznego u pacjentki hospitalizowanej w Klinice Psychiatrii Młodzieżowej, w kontekście twórczości spontanicznej oraz inspirowanej w trakcie indywidualnych zajęć arteterapii. Proces rediagnozy – z choroby afektywnej dwubiegunowej na zaburzenia schizoafektywne – został zapoczątkowany w toku omawiania prac plastycznych pacjentki. W jej twórczości podczas kolejnej fazy depresyjnej bez objawów psychotycznych zaczęły występować: cechy znacznej dezorganizacji, symbole, deformacja postaci, kontaminacje, nieuzasadnione treścią podziały przestrzeni, zachwiania perspektywy, o kilka miesięcy wyprzedzające rozwój pełnoobjawowej psychozy o obrazie schizofrenii. Osiemnastoletnia pacjentka, chorująca od roku, początkowo była leczona z powodu manii w przebiegu choroby afektywnej dwubiegunowej. Prezentowała podwyższony nastrój i napęd, przyspieszony tok myślenia, wypowiadała urojenia wielkościowe, posłannicze, skracała dystans, relacjonowała „wyostrzenie zmysłów”, „poszerzenie świadomości”, chciała „nieść światu piękno”. Relacjonowała, że od dawna obserwuje u siebie wahania nastroju – od stanów „depresji” z uczuciem smutku, wyczerpania, anhedonii, nadmierną sennością, znacznym spadkiem aktywności, myślami samobójczymi do stanów „euforii”, „hiperaktywności”. Krótko po wypisie pacjentka odstawiła leki i po kilku miesiącach trafiła ponownie na oddział z objawami epizodu depresji i tendencjami samobójczymi. W trakcie tej hospitalizacji pacjentce zaproponowano udział w indywidualnych zajęciach arteterapeutycznych z uwagi na jej spontaniczną twórczość plastyczną (w tym malowanie na ścianach oraz odmowę udziału w zajęciach grupowych. Zespół terapeutyczny, w skład którego wchodziła arteterapeutka, określił następujące cele arteterapii: diagnostyczny, komunikacyjny, integracyjny i katartyczny

  18. Opiate addiction : neuronal plasticity on brain reward system and emotional memory-related areas = Adicción a opiáceos : plasticidad neuronal en los circuitos neuronales de recompensa y en áreas de memoria emocional

    OpenAIRE

    García Pérez, Daniel

    2015-01-01

    Los opiáceos, como la morfina, son unos potentes analgésicos que se usan para tratar diversas formas de dolor agudo y crónico. Sin embargo, el uso crónico de opiáceos produce cambios neuroadaptativos a nivel cerebral que conllevan efectos indeseables, como la adicción. La creciente evidencia implica a varios mecanismos de regulación génica (incluyendo epigenéticos, moleculares, celulares y a nivel de circuitos neuronales) en los cambios que las drogas de abuso provocan en el cerebro, siendo e...

  19. La legalización de la marihuana y el abuso de opiáceos prescritos conrta el dolor: como un estado progresista de Estados Unidos afronta el desafío

    OpenAIRE

    Cepeda-Benito, Antonio; Bueno-Cañigral, F. J.; Castelló-Cogollos, Lourdes; Vescna, Adriana

    2016-01-01

    Libro que recoje la IX Edición de Debates en Drogodependencia con la conferencia titulada: "La legalización de la marihuana y el abuso de opiáceos prescritos contra el dolor: como un estado progresista de Estados Unidos afronta el desafío", celebrada en Valencia el 10 de mayo de 2016 e impartida por el Profesor Dr. D. Antonio Cepeda-Benito.

  20. The Effectiveness of Diagnostic Assessment on the Development of Turkish Language Learners’ Narrative Skills as an Oral Proficiency Interview (OPI Task

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    Anjel Tozcu

    2016-07-01

    Full Text Available This study investigated the effectiveness of diagnostic assessment on improving students’ proficiency in narrating past events, an Oral Proficiency Interview (OPI Level 2 task. It found that students who were given a personalized learning plan subsequent to the diagnostic assessment interview significantly improved their proficiency in basic sentence structures than those in a control group. They used a significantly larger number of cohesive devices as compared to the control group and exhibited significantly increased accuracy in using cohesive devices than a control group. The students in the treatment group worked on the recommended activities based on the data gathered during the diagnostic assessment interview and the pre-interview questionnaires, i.e., the E & L, MBTI, and Barsch. The students in the control group spent the same amount of time reading narrations, doing comprehension exercise,s and following standard teacher feedback for improvement. Although both groups showed increases in accurate use of cohesive devices and proficiency in basic sentence structures, the treatment students showed significantly greater gains than the control students.

  1. Dyskopatia kręgosłupa w odcinku lędźwiowym u 10 - letniego dziecka - opis przypadku = Discopathy of the lumbar spine in a 10 - years old child - case study

    OpenAIRE

    Woźniak, Kamila; Ratuszek-Sadowska, Dorota; Śniegocki, Maciej

    2015-01-01

    Woźniak Kamila, Ratuszek-Sadowska Dorota, Śniegocki Maciej. Dyskopatia kręgosłupa w odcinku lędźwiowym u 10 - letniego dziecka - opis przypadku = Discopathy of the lumbar spine in a 10 - years old child - case study. Journal of Education, Health and Sport. 2015;5(9):351-362. ISSN 2391-8306. DOI 10.5281/zenodo.30934 http://dx.doi.org/10.5281/zenodo.30934 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%289%29%3A351-362 https://pbn.nauka.gov.pl/works/624249 Formerly Jo...

  2. Chirurgiczne leczenie zatoki włosowej z zastosowaniem Z-plastyki – opis przypadku i przegląd piśmiennictwa

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    Dariusz Pakuła

    2010-12-01

    Full Text Available Wprowadzenie. Zatoka włosowa jest przewlekłym stanem zapalnymzlokalizowanym w szparze międzypośladkowej. Pomimo iż pierwszyopis chirurgicznego leczenia tej choroby pochodzi z 1847 roku, to jejterapia wciąż stanowi duże wyzwanie na oddziałach chirurgicznychw Polsce. Obecnie torbiel włosowa może być leczona zarówno zachowawczo,jak i chirurgicznie.Cel pracy. Przedstawienie przypadku chirurgicznego leczenia pacjentaz zatoką włosową oraz przegląd najnowszego piśmiennictwa odnoszącegosię do tego problemu.Opis przypadku. Chory 30-letni został przyjęty na Oddział ChirurgiiOgólnej i Naczyniowej Wojewódzkiego Specjalistycznego Szpitala im.M. Pirogowa w Łodzi z powodu zatoki włosowej celem wykonaniaplanowego zabiegu operacyjnego. U chorego wykonano operacjędoszczętnego wycięcia zatoki włosowej z zastosowaniem Z-plastyki.Przebieg pooperacyjny był niepowikłany. Obecnie chory jest pod kontroląprzyszpitalnej poradni proktologicznej. Po 5 miesiącach odmomentu wykonania zabiegu operacyjnego u pacjenta nie stwierdzononawrotu zatoki włosowej.Wnioski. Wyniki chirurgicznego leczenia torbieli włosowej w Polscenadal nie są w pełni zadowalające ze względu na częste wznowy. Szerokiewycięcie zatoki włosowej, a następnie zastosowanie Z-plastykipozwala skutecznie leczyć pacjentów z tą chorobą. Autorzy artykułuuważają, że ze względu na dużą liczbę powikłań i nawrotów po chirurgicznymleczeniu zatoki włosowej zabiegi tego typu powinny byćwykonywane tylko w wysokospecjalistycznych placówkach.

  3. Funkcjonowanie poznawcze i emocjonalne pacjentki z rodzinnie uwarunkowaną postacią zespołu jedzenia nocnego – opis przypadku

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    Magdalena Obrembska

    2017-11-01

    Full Text Available Wstęp: W Diagnostic and Statistical Manual of Mental Disorders (DSM-5 zespół jedzenia nocnego zaklasyfikowany został do innych specyficznych zaburzeń odżywiania. Szacuje się, że zespół ten dotyczy około 1,5% populacji; częstość występowania postaci rodzinnej nie jest znana. Materiał i metody: Wykorzystano Kwestionariusz Jakości Snu Pittsburgh, Mini-Addenbrooke’s Cognitive Examination, Test Figury Złożonej Reya–Osterrietha, Test Łączenia Punktów A i B, Test 15 słów Reya, Inwentarz Depresji Becka, Inwentarz Stanu i Cechy Lęku oraz swobodne techniki diagnostyczne. Opis przypadku: W artykule zaprezentowano przypadek 35-letniej pacjentki hospitalizowanej z powodu zaburzeń snu i epizodów objadania się w nocy występujących od około 15 lat. Nie stwierdzono objawów depresyjnych, lękowych, wytwórczych ani objawów świadczących o anoreksji czy bulimii. W badaniu neurologicznym nie odnotowano odchyleń od staniu prawidłowego, co potwierdziły badanie obrazowe głowy z kontrastem, badanie elektroencefalograficzne i badania biochemiczne. Wywiad rodzinny wskazywał na występowanie podobnych objawów u dwóch członków rodziny. Wyniki: Wyniki badania psychologicznego potwierdziły obniżenie jakości snu, a także pogorszenie funkcjonowania poznawczego w aspekcie krótkotrwałej pamięci werbalnej i zdolności koncentracji uwagi oraz obniżenie poziomu fluencji semantycznej w wąskim zakresie. Wnioski: Po przeprowadzeniu diagnostyki różnicowej ustalono rozpoznanie rodzinnej postaci zespołu jedzenia nocnego. Zważywszy na rzadkość omawianego schorzenia w populacji, potrzebne jest pogłębienie badań dotyczących tej postaci zespołu.

  4. Perfil da indicação de analgésicos opióides em recém-nascidos em ventilação pulmonar mecânica

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    Castro M. Cristina F.Z.

    2003-01-01

    Full Text Available Objetivo: identificar fatores que levaram os médicos a prescreverem opióides a recém-nascidos em ventilação mecânica. Método: estudo retrospectivo de pacientes em ventilação mecânica por cânula traqueal, por mais de 1 hora, internados em UTI neonatal entre janeiro de 1995 a junho de 1997. Nesse período, 203 recém-nascidos preencheram o critério de inclusão, recuperando-se 176 prontuários. Os prontuários foram analisados quanto a dados demográficos, características da analgesia e do suporte ventilatório, procedimentos invasivos realizados e entidades mórbidas diagnosticadas durante o período de ventilação. Para entender os fatores que determinaram o uso da analgesia em parte dessa população, utilizou-se a análise discriminante. Resultados: Nos 97 pacientes que receberam > 1 dose de opióides durante a ventilação, a analgesia foi iniciada, em média, até 24 horas após o início da ventilação. As escalas de avaliação da dor não foram usadas em nenhum paciente e, em 63%, não havia relato do motivo para a analgesia. A análise discriminante mostrou que as variáveis que diferenciaram os grupos submetidos ou não à analgesia foram: peso ao nascer, idade gestacional, índice de oxigenação e número de punções arteriais. Os neonatos com maior chance de receberem alguma dose de opióide durante a ventilação foram os de peso mais elevado, idade gestacional mais avançada, índice de oxigenação mais acentuado no início da ventilação e maior necessidade de gasometrias, ou seja, os bebês mais maduros e com doença respiratória mais grave. Conclusão: os médicos não levam em conta a dor propriamente dita e nem a avaliam para decidirem pela necessidade de analgesia no neonato em ventilação

  5. Diretrizes para o tratamento de pacientes com síndrome de dependência de opióides no Brasil Brazilian guideline for the treatment of patients with opioids dependence syndrome

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    Danilo Antonio Baltieri

    2004-12-01

    Full Text Available Existe uma prevalência relativamente baixa do uso de ópioides no Brasil, em particular envolvendo o uso não médico da codeína e de xaropes que contêm opióides. No entanto, a síndrome de dependência apresenta um significativo impacto total na mortalidade e morbidade. Nos últimos 20 anos, o avanço científico tem modificado nosso entendimento sobre a natureza da adição aos opióides e os variados tratamentos possíveis. A adição é uma doença crônica tratável se o tratamento for realizado e adaptado tendo em vista as necessidades do paciente específico. Há, de um fato, um conjunto de tratamentos que podem efetivamente reduzir o uso da droga, ajudar a gerenciar a fissura pela droga, prevenir recaídas e recuperar as pessoas para o funcionamento social produtivo. O tratamento da dependência de drogas será parte de perspectivas de longo prazo do ponto de vista médico, psicológico e social. Esta diretriz almeja fornecer um guia para os psiquiatras e outros profissionais de saúde que tratam de pacientes com Síndrome de Dependência de Opióides. Ela tece comentários sobre o tratamento somático e psicossocial que é utilizado nesses pacientes e revisa as evidências científicas e seu poder. Da mesma forma, os aspectos históricos, epidemiológicos e neurobiológicos da dependência de opióides são revisados.There is a relatively low prevalence of opioid use in Brazil, particularly involving the non-medical use of codeine and opiate-containing syrups. However, opioid dependence syndrome shows a significant total impact on mortality and morbidity. Over the past 20 years, scientific progress has changed our understanding of the nature of opioid addiction and its various possible treatments. Addiction is a chronic illness treatable if the treatment is well-delivered and tailored to the needs of the particular patient. There is indeed an array of treatments that can effectively reduce drug use, help manage drug cravings

  6. Uma breve história do ópio e dos opióides Una historia breve del opio y de los opioides Opium and opioids: a brief history

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    Danilo Freire Duarte

    2005-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Desde tempos imemoriais, o ópio e os seus derivados, além de exercerem ponderável influência sobre o comportamento dos seres humanos, têm sido empregados como sedativo e como analgésico. A partir do século XIX, com o isolamento dos alcalóides do ópio e as facilidades para o emprego dessas substâncias por via parenteral, houve aumento do interesse pelo uso criterioso dos opióides na área médica e da análise das conseqüências sociais de seu uso abusivo. Justifica-se, pelo exposto, uma revisão histórica do ópio e dos seus derivados. CONTEÚDO: A evolução dos conhecimentos sobre o ópio, produto natural extraído do Papaver somniferum, e sobre os opióides, substâncias naturais, semi-sintéticas e sintéticas extraídas do ópio, bem como as principais referências a essas substâncias desde a Antigüidade foram avaliadas. Foi enfatizado o progresso obtido a partir dos trabalhos de Setürner que resultaram no isolamento da morfina. As investigações conduzidas por outros autores na busca de substâncias sintéticas que apresentassem vantagens sobre os produtos naturais foram mencionadas. A importância da descoberta dos receptores opióides e de seus ligantes endógenos foi sublinhada. CONCLUSÕES: No alvorecer do terceiro milênio, a despeito das pesquisas realizadas com drogas analgésicas de outros grupos farmacológicos, os opióides continuam sendo os analgésicos mais potentes, embora sua eficácia seja contestada em certos tipos de dor. Os atuais conhecimentos de Farmacologia Clínica permitem selecionar o opióide a ser administrado, considerando a doença e as condições do paciente, na busca da melhor relação custo-benefício.JUSTIFICATIVA Y OBJETIVOS: Desde tiempos inmemoriales, el opio y sus derivados, junto con ejerceren ponderable influencia sobre el comportamiento de los seres humanos, han sido empleados como sedante y como analgésico. Desde el siglo XIX, con el aislamiento de los

  7. Struniak w okolicy kości krzyżowej u 47 – letniej pacjentki – opis przypadku = Chordoma in the sacral spine in an 47-year-old woman – case report

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    Kamila Woźniak

    2016-09-01

    • 2.        Katedra i Klinika Rehabilitacji, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu     Streszczenie   Struniaki (łac. chordoma są rzadkimi, histologicznie łagodnymi, lecz klinicznie złośliwymi nowotworami szkieletu osiowego. Mogą powstać w dowolnym miejscu w linii środkowej ciała, gdzie istniała struna grzbietowa (np. stok, nosogardziel, siodło i okolica okołosiodłowa, otwór wielki kręgi i okolica krzyżowo-ogonowa. Struniaki to wolno rosnące nowotwory, wykazujące miejscową agresywność w stosunku do kości i tkanek miękkich. Struniaka po raz pierwszy opisał w 1856 roku Virchow i Luschke. Z kolei w 1858 roku Muller stwierdził, że nowotwór może pochodzić z pozostałości embrionalnych prymitywnej struny grzbietowej tzw. chorda dorsalis. Autorzy przedstawiają opis przypadku klinicznego leczonego operacyjne w Klinice Neurochirurgii, Neurotraumatologii i Neurochirurgii Dziecięcej Szpitala Uniwersyteckiego nr 1 im. dr A. Jurasza w Bydgoszczy z rozpoznanym w badaniu histopatologicznym struniakiem.   Słowa kluczowe: struniak, chrodoma, nowotwór, szkielet osiowy, neurochirurgia.     Abstract   Chordomas are rare, histologically benign but clinically malignant tumors of the axial skeleton. They can occur anywhere in the midline of the body where there notochord (clivus, nasopharynx, saddle and surroundings parasellar, the foramen vertebrae and surroundings sacral area. Chordomas are slow-growing cancer, showing local aggressiveness relative to bone and soft tissue. Chordoma was first described in 1856 by Virchow and Luschke. In turn, in 1858 Muller found that the cancer can come from embryonic remnants of the primitive notochord called chorda dorsalis. The authors present a clinical case operating treated in the Department of Neurosurgery, Neurotraumatology and Pediatric Neurosurgery, Dr Antoni Jurasz University Hospital No.1 in Bydgoszcz histopathological diagnosed

  8. Dyskopatia kręgosłupa w odcinku lędźwiowym u 10 - letniego dziecka - opis przypadku = Discopathy of the lumbar spine in a 10 - years old child - case study

    Directory of Open Access Journals (Sweden)

    Kamila Woźniak

    2015-09-01

    2.Chair and Department of Rehabilitation Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland   Streszczenie Dyskopatia lędźwiowa stanowi niezwykle rzadki problem występujący u dzieci i młodzieży. W 1945 roku Wahren przedstawił pierwszy opis dotyczący dyskopatii kręgosłupa w odcinku lędźwiowo - krzyżowym u dziecka. Dyskopatia lędźwiowa w populacji pediatrycznej występuje niezmiernie rzadko, a jeszcze rzadziej wymaga interwencji operacyjnej. Powszechnie uważa się, że czynnikami predysponującymi do występowania dyskopatii w odcinku lędźwiowo - krzyżowym w populacji pediatrycznej są dyscypliny sportowe związane ze zwiększonym ryzykiem urazu lub nadmiernymi obciążeniami kręgosłupa, otyłość, wysoki wzrost, przebyty uraz okolicy lędźwiowo – krzyżowej. Dyskopatia u dzieci i młodzieży wykazuje pewne cechy charakterystyczne różniące ją od dorosłych. W literaturze światowej istnieje wiele prac dotyczących metod postępowania w leczeniu dyskopatii kręgosłupa w populacji pediatrycznej, ale nie ma jednoznacznych wytycznych dotyczących kwalifikacji chorych do leczenia operacyjnego. Autorzy przedstawiają opis przypadku klinicznego: 10 - letniego chłopca operowanego z powodu wypukliny jądra miażdżystego w przestrzeni L5/S1. Leczenie chirurgiczne dyskopatii kręgosłupa w odcinku lędźwiowo - krzyżowym u dzieci i młodzieży jest metodą, uzasadnioną tylko wtedy, gdy leczenie zachowawcze okaże się nieskuteczne. Z drugiej strony w przypadku ewidentnego braku efektywności leczenia zachowawczego, nie należy zbyt długo zwlekać z decyzją o podjęciu leczenia operacyjnego. W populacji pediatrycznej wybór metody leczenia i kwalifikacja do leczenia chirurgicznego musi wynikać każdorazowo z wnikliwej analizy każdego przypadku.   Słowa kluczowe: dyskopatia, odcinek lędźwiowy kręgosłupa, przepuklina krążka międzykręgowego, populacja pediatryczna, fenestracja.   Abstract

  9. Idiopatyczny przerost opony twardej – opis przypadku

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    Andrzej Klimek

    2011-07-01

    Full Text Available Idiopatyczny przerost opony twardej to rzadkie schorzenie o niejasnej patogenezie. W literaturze światowej do 2010 roku opisano około 100 przypadków, z czego większość w ostatnim dziesięcioleciu. Niniejszym chcieliśmy przedstawić przypadek 52-letniej kobiety, która została przyjęta do Kliniki Neurologii i Epileptologii Uniwersytetu Medycznego w Łodzi w sierpniu 2010 roku. Choroba rozpoczęła się osłabieniem ostrości widzenia oka lewego w 2007 roku. Z tego powodu pacjentka była hospitalizowana na oddziale okulistycznym, a następnie neurologicznym, jednakże nie ustalono rozpoznania przyczynowego. Miała wielokrotnie wykonywane badanie CT głowy, które wypadało prawidłowo. W maju 2009 roku z powodu zaburzeń kardiologicznych implantowano chorej kardiostymulator, co w przyszłości wykluczało możliwość wykonania MRI. W sierpniu 2009 roku stwierdzono już całkowity zanik nerwu II oka lewego oraz zaczynający się zanik nerwu II po stronie prawej. W lutym 2010 roku bóle głowy zmieniły swoją częstość – ze sporadycznych stały się codzienne. Po przyjęciu pacjentki do szpitala w 2010 roku badanie CT głowy ujawniło krwiaka przymózgowego. Mimo istniejących objawów ucisku prawej komory bocznej, z jej przemieszczeniem, chora nie została zakwalifikowana do zabiegu. Po ponownej hospitalizacji w sierpniu 2010 roku, z powodu braku ewolucji krwiaka i narastających przemieszczeń pacjentkę przeniesiono do Kliniki Neurochirurgii. W trakcie zabiegu stwierdzono pogrubiałą oponę twardą (około 7 mm, której fragmenty przesłano do badania histopatologicznego. Wykazało ono zmiany o charakterze włóknisto-ziarnistym. U chorej wykonano szereg badań laboratoryjnych w celu ustalenia przyczyny przerostu opony twardej, które wypadły negatywnie, co wskazuje na idiopatyczny przerost opony twardej.

  10. Samouszkodzenia jako symptom prodromalny schizofrenii. Opis przypadku

    Directory of Open Access Journals (Sweden)

    Konstantinos Tsirigotis

    2010-06-01

    Full Text Available Celem pracy było przedstawienie przypadku chorego na schizofrenię, który przed ostatecznym zdiagnozowaniem schizofrenii dokonywał samouszkodzeń. Pacjentem był student w wieku 23 lat, a powodem zgłoszenia do psychologa samouszkodzenie. Zgłosił się z matką, zaniepokojoną jego czynem. Pacjent był zorientowany prawidłowo co do miejsca, czasu i własnej osoby, w kontakcie pozornie dobrym. Na lewym ramieniu widać było ranę ciętą. Odczuwał stany agresji, co było powodem dokonywania samouszkodzeń. Prowadził nocny tryb życia, wówczas inni ludzie nie przeszkadzali mu. Jego wypowiedzi były logiczne, zborne, brak było oznak zaburzeń myślenia. Nie sprawiał wrażenia przejętego swoimi przeżyciami i tym, co się z nim dzieje; wyrażane przez niego emocje nie były dostosowane do treści jego wypowiedzi. Jego profil w MMPI był „nerwicowy”, ale inne wskaźniki (kliniczne, diagnostyczne i różnicowe nasuwały podejrzenie psychozy. Dane z wywiadu, rozmowy, obserwacji i MMPI sprawiły, że pacjent został skierowany do psychiatry z podejrzeniem zaburzeń schizofrenicznych. O objawach pozytywnych (produktywnych zaczął mówić dopiero przy analizie treściowej pozycji krytycznych MMPI. Rozpoznanie psychiatryczne potwierdziło podejrzenia schizofrenii; został hospitalizowany i był leczony z rozpoznaniem schizofrenii paranoidalnej. W tym przypadku początek schizofrenii był powolny, ubogoobjawowy, bez objawów ostrych. Przedchorobowa osobowość pacjenta nosiła cechy schizotymii, autystycznego izolowania się – najprawdopodobniej była to już osobowość schizoidalna. Zagadnienie izolowania się można rozpatrywać również w kategoriach zapotrzebowania na stymulację i optimum stymulacji. Odrębnym zagadnieniem są związki samouszkodzeń z substancjami (endorfiny, encefaliny itp. wydzielanymi podczas tego typu autostymulacji. Powyższe dane potwierdzają jeszcze raz znaczenie diagnozy klinicznej (w odróżnieniu od psychometrycznej i wagę jakościowej, klinicznej interpretacji danych psychometrycznych, testowych.

  11. Personnel Investigations and Clearance Tracking (OPI)

    Data.gov (United States)

    Office of Personnel Management — Security file-related information for the U.S. Office of Personnel Management (OPM)'s employee and contractor personnel. The data is OPM-specific, not government-wide.

  12. O uso de opióides no tratamento da dor crônica não oncológica: o papel da metadona El uso de opioides en el tratamiento del dolor crónico no oncológica: el papel de la metadona Opioids for treating non malignant chronic pain: the role of methadone

    Directory of Open Access Journals (Sweden)

    Sady Ribeiro

    2002-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O uso de opióides em dor oncológica já é bastante difundido e comprovado por diversos ensaios clínicos bem controlados. Entretanto, há uma grande controvérsia em relação ao uso em longo prazo de opióides em dor crônica de origem não oncológica, que tem se intensificado de forma importante nos últimos anos. Neste estudo, objetivamos avaliar criticamente as informações disponíveis na literatura a respeito do uso de opióides para tratamento de dor crônica não oncológica e o papel da metadona como opção terapêutica. CONTEÚDO: Os estudos disponíveis ainda são limitados, mas demonstram que determinadas subpopulações de pacientes portadores de dor crônica podem alcançar analgesia importante, com pouca tolerância e baixo potencial para adição, principalmente aqueles refratários aos esquemas terapêuticos convencionais. Morfina é o opióide padrão, mas outras alternativas podem ser utilizadas como oxicodona, hidromorfona ou fentanil. Metadona é um opióide sintético, inicialmente utilizado para prevenir síndrome de abstinência em paciente dependentes, que também constitui uma importante opção no tratamento da dor crônica não oncológica, principalmente dor neuropática. CONCLUSÕES: Apesar do conhecimento crescente sobre o uso de opióides em dor crônica não oncológica, novos estudos melhor controlados ainda são necessários para uma discussão mais científica a respeito do assunto. A metadona administrada por via oral apresenta uma boa relação custo-benefício, representando uma alternativa efetiva para um melhor controle da dor em alguns pacientes.JUSTIFICATIVA Y OBJETIVOS: El uso de opioides en el dolor oncológico ya es bastante difundido y comprobado por diversos ensayos clínicos bien controlados. Entretanto, hay una grande controversia en relación con el uso en largo plazo de opioides en el dolor crónico de origen no oncológica, que se ha intensificado de forma

  13. The great neglected outdoor classroom! | Opie | Southern African ...

    African Journals Online (AJOL)

    The attitudes of a small sample of teachers in the Western Cape towards fieldwork as a teaching methodology are analysed and discussed. Tentative conclusions are drawn as to why teachers either use or avoid using this approach to teaching.

  14. OPI Special Education Endorsement Project: A State-University Partnership.

    Science.gov (United States)

    Burdge, Jolene A.; Fishbaugh, Mary Susan E.; Christensen, Linda

    2003-01-01

    An evaluation of Montana's alternative certification program for special education teachers surveyed 117 current students, graduates, mentors, and administrators. Results indicated appreciation for the program but perceived needs for more instruction in severe disabilities, behavior management, development of individualized education programs, and…

  15. Vanha koira ei opi uusia temppuja / Lasse Lehtinen

    Index Scriptorium Estoniae

    Lehtinen, Lasse

    2008-01-01

    Euroopa Parlamendi liige Eesti ja Soome välispoliitika erinevustest Venemaa suhtes. Autor tsiteerib katkendeid artiklist: Ilves, Toomas Hendrik. Meloslaisia muistellen. Kanava, 2008, nr. 8, lk. 640-646

  16. Rodzinne występowanie zespołu Treachera Collinsa – opis 6 rodzin

    Directory of Open Access Journals (Sweden)

    Małgorzata Kot

    2009-06-01

    Full Text Available Zaliczany do żuchwowo-twarzowych dyzostoz zespół Treachera Collinsa (TCS jest autosomalnym dominującym zaburzeniem rozwoju czaszki twarzowej. Występuje w populacji ogólnej z częstością 1/50 000 żywych urodzeń. Zespół ten powstaje na skutek wczesnych zaburzeń embriogenezy pierwszego i drugiego łuku skrzelowego. W 40% przypadków stwierdzono rodzinne występowanie zaburzeń, natomiast w 60% choroba ta jest wynikiem mutacji de novo w genie TCOF1, na chromosomie 5q32-q33.1. Gen TCOF1 składa się z 26 eksonów i koduje białko zwane treacle, złożone z 1411 aminokwasów. Opisano około 116 różnych mutacji TCOF1, spośród których najczęstsze są delecje. Obraz kliniczny TCS obejmuje: antymongoloidalne ustawienie szpar powiekowych, rozszczep powiek dolnych, zmniejszenie liczby rzęs, „językowate” owłosienie na policzkach, podniebienie wysoko wysklepione lub rozszczepione, makrostomię, niedorozwój kości jarzmowej oraz żuchwy, niedorozwój ucha zewnętrznego, środkowego, rzadziej wewnętrznego. Pacjenci wymagają wieloetapowego leczenia chirurgicznego, na które składa się: plastyka kości twarzy, rekonstrukcja małżowin usznych, korekcja antymongoloidalnego ustawienia szpar powiekowych, plastyka rozszczepionego podniebienia, plastyka powiek. Poza leczeniem chirurgicznym chorzy wymagają leczenia wielospecjalistycznego z udziałem pediatrów, laryngologów, logopedów i ortodontów. Ponieważ zakres i stopień deformacji obserwowanych w TCS jest rozległy, plan postępowania terapeutycznego powinien być dostosowany do indywidualnych potrzeb pacjenta. W pracy przedstawiono analizę 6 rodzin, w których obserwowano TCS. Autorzy przeanalizowali płeć i stopień pokrewieństwa chorych oraz zmianę nasilenia zaburzeń rozwojowych w kolejnych pokoleniach.

  17. Zmiany skórne w przebiegu ostrej białaczki szpikowej – opis przypadku

    Directory of Open Access Journals (Sweden)

    Waldemar Placek

    2011-08-01

    Full Text Available Introduction. Acute myeloid leukaemia is a malignant neoplastic diseaseof white blood cells. About 80% of acute leukaemias in adult arediagnosed as myeloid leukaemias. The presence of transformed cellclones in bone marrow and blood, which originate from very earlystages of myelopoiesis, is characteristic. Beside systemic symptoms(anaemia, thrombocytopenia there are infiltrations in other organs,including skin. Skin lesions are most frequently non-specific (pruritus,skin spots, erythema multiforme, bullous pemphigoid but can be alsospecific (skin tumours. Cases of diffuse xanthomatoses and myeloidsarcoma have also been found in patients with acute myeloidleukaemia. Skin lesions are present more often in lymphocytic thanmyeloid leukaemias. They may precede the disease or its relapse, occurconcomitantly or after systemic symptoms, and sometimes may be ofprognostic value.Objective. To present the case of a patient in whom skin lesions werethe cause of detailed examinations, which revealed acute myeloidleukaemia.Case report. We present a case of a 61-year old patient with purplebrownnodular lesions 1-3 cm in diameter on the face, scalp skin, trunk,limbs and the oral cavity’s mucous membranes with coexistent intensepruritus and generalized lymphadenopathy. The first skin lesionsoccurred three months earlier. During hospitalization in the Departmentof Dermatology the renewal of blasts in the circulatory blood wasobserved and skin biopsy revealed a large amount of mononuclearcells. The patient was directed to the haematological ward, where thediagnosis of acute myeloid leukaemia was established.Conclusions. Our case indicates that the presence of skin lesions andthorough diagnostic procedures may contribute to the diagnosis ofmalignant neoplastic diseases of white blood cells.

  18. Stosowanie wenlafaksyny w dawkach podzielonych – opis kazuistyczny

    Directory of Open Access Journals (Sweden)

    Łukasz Święcicki

    2015-04-01

    Full Text Available Wenlafaksyna jest lekiem o co najmniej dwóch istotnych mechanizmach działania przeciwdepresyjnego. Hamowanie wychwytu zwrotnego serotoniny (5-HT ujawnia się już podczas stosowania niskich dawek, a hamowanie wychwytu zwrotnego noradrenaliny – dopiero przy dawkach istotnie wyższych. Za punkt odcięcia przyjmuje się na ogół dawkę 225 mg na dobę, choć zmiana z jednego mechanizmu działania na dwa ma najprawdopodobniej charakter spektralny. Możliwe, że w dawkach powyżej 375 mg na dobę lek wykazuje również działanie dopaminergiczne, ale tak duże dawki wenlafaksyny nie są zalecane przez producenta. Stosowanie wyższych dawek przekłada się na większą skuteczność przeciwdepresyjną leku. Należy jednak pamiętać, że zmiana dawki może być związana z ujawnieniem się odmiennego profilu działań niepożądanych (choć zależy to także od indywidualnej wrażliwości pacjenta. Działanie serotoninergiczne bywa odbierane jako uspokajające, sedujące, powodujące nadmierną senność, a nawet zobojętnienie i apatię. Działanie noradrenergiczne może z kolei wywoływać uczucie nadmiernego pobudzenia i zaburzenia snu. To, czy dane działanie jest odczuwane jako niewpływające na funkcjonowanie, czy też jako trudne do zniesienia, zależy ponadto od pory dnia, w której występuje. Działanie nasenne pacjent uzna za korzystne wieczorem, natomiast działanie rozbudzające – rano. Wydaje się, że pora podawania wenlafaksyny może wpływać na subiektywną tolerancję leku. W artykule opisano dwie sytuacje ilustrujące ten punkt widzenia. Nie jest do końca jasne, dlaczego pacjenci odczuwają działanie leku najsilniej wkrótce po jego przyjęciu (nie da się wykluczyć swoistego efektu placebo. Mimo to w przypadku wielu chorych subiektywna tolerancja wenlafaksyny bez wątpienia ma związek ze sposobem podawania leku; lekarze powinni brać tę okoliczność pod uwagę.

  19. Charakterizace integrasy Masonova-Pfizerova opičího viru

    Czech Academy of Sciences Publication Activity Database

    Krejčík, Z.; Snášel, Jan; Rosenberg, Ivan; Ruml, T.; Pichová, Iva

    2002-01-01

    Roč. 96, č. 4 (2002), s. 223 ISSN 0009-2770. [Sigma-Aldrich konference mladých chemiků, biochemiků a molekulárních biologů. 22.05.2002-25.05.2002, Velké Meziříčí] Institutional research plan: CEZ:AV0Z4055905 Keywords : Mason-Pfizer monkey virus Subject RIV: CE - Biochemistry

  20. Guz olbrzymiokomórkowy - opis przypadku = Giant cell tumor - case report

    Directory of Open Access Journals (Sweden)

    Jolanta Białkowska-Głowacka

    2016-01-01

    Kierownik: dr hab. n. med., prof. nadzw. Anna Janas-Naze     Adres do korespondencji: dr n. med. Piotr Osica Zakład Chirurgii Stomatologicznej UM w Łodzi 92-213 Łódź, ul. Pomorska 251 mail: piotr.osica@umed.lodz.pl   Praca finansowana przez UM w Łodzi w ramach działalności statutowej nr 503/2-163-01/503-21-001.   Streszczenie   W pracy przedstawiono przypadek pacjentki u której obserwowano przez kilka miesięcy  zmianę na błonie śluzowej szczęki, bez weryfikacji diagnostycznej. Podkreślono jak ważną rolę pełni lekarz stomatolog w monitorowaniu zmian w jamie ustnej, przedstawiono niektóre metody diagnostyczne niezbędne do ustalenia rozpoznania.   Słowa kluczowe: guz olbrzymiokomórkowy, badanie histopatologiczne, diagnostyka.   Summary   The article describes a case of a patient, in which over a few months period, a lesion on the maxillary mucosa has been observed, without earlier histopathological verification. The important role of a dentist in monitoring the lesions in oral cavity has been underlined. The authors discuss also certain diagnostic methods, necessary for confirming the diagnosis.   Key words: giant cell tumor, histological examination, diagnosis.

  1. Ventilation system in the RA reactor building - design specifications; Sistem ventilacije u objektu 'RA' - Tehnicki opis

    Energy Technology Data Exchange (ETDEWEB)

    Badrljica, R [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1984-09-15

    Protective role of the ventilation system of nuclear facilities involve construction of ventilation barriers which prevent release of radioactive particulates or gases, elimination od radioactive particulates and gases from the air which is released from contaminated zones into the reactor environment. Ventilation barriers are created by dividing the building into a number of ventilation zones with different sub pressure compared to the atmospheric pressure. The RA reactor building is divided into four ventilation zones. First zone is the zone of highest risk. It includes reactor core with horizontal experimental channels, underground rooms of the primary coolant system (D{sub 2}O), helium system, hot cells and the space above the the reactor core. Second zone is the reactor hall and the room for irradiated fuel storage. The third zone includes corridors in the basement, ground floor and first floor where the probability of contamination is small. The fourth zone includes the annex where the contamination risk is low. There is no have natural air circulation in the reactor building. Ventilators for air input and outlet maintain the sub pressure in the building (pressure lower than the atmospheric pressure). This prevents release of radioactivity into the atmosphere. Zastitne uloge ventilacionog sistema kod nuklearnih postrojenja obuhvataju formiranje ventilacionih barijera koje onemugucavaju sirenje radioaktivnih cestica ili gasova putem cirkulacije vazduha; eliminaciju radioaktivnih cestica i gasova iz vazduha koji se evakuise iz kontaminiranih prostora u okolinu reaktorskog postrojenja. Formiranje zastitnih ventilacionih barijera ostvaruje se obicno podelom unutrasnjosti objekta na vise ventilacionih zona razlicitih podpritisaka u odnosu na spoljni atmosferski pritisak. Celi prostor zgrade reaktora RA podeljen je u cetiri ventilacione zone. Prva zona je zona najveceg rizika, u koju spadaju reaktorsko jezgro sa horizontalnim eksperimentalnim kanalima, tehnoloske prostorije suterena u kome je primarno kolo hladjenja (D{sub 2}O), sistem helijuma, vruce komore i prostor iznad radne platforme reaktora. Druga zona je reaktorska hala i prostorija za odlezavanje goriva. Treca zona obuhvata komunikacione hodnike suterena, prizemlja i sprata, gde je verovatnoca radioaktivnog zagadjenja mala. Cetvrta zona obuhvata prostorije aneksa koje nisu radioaktivno opasne zone. Zgrada nema prirodnu ventilaciju. U zgradi se ventilatorima za dovod i odvod vazduha odrzava mali podpritisak u odnosu na spoljasnji pritisak sto onemugacava isticanje radioaktivnih zagadjivaca u atmosferu.

  2. Bezobjawowa aspiracja wiertła stomatologicznego do dolnych dróg oddechowych – opis przypadku

    Directory of Open Access Journals (Sweden)

    Katarzyna Wochna

    2014-10-01

    Full Text Available W niniejszej pracy przedstawiono przypadek mężczyzny, u którego podczas leczenia stomatologicznego doszło do bezobjawowej aspiracji wiertła stomatologicznego do dolnych dróg oddechowych. Brak jakichkolwiek objawów aspiracji ciała obcego mylnie zasugerował lekarzom połknięcie i przedostanie się go do żołądka, co nie zostało wykluczone kontrolnym zdjęciem radiologicznym klatki piersiowej. Dopiero kolejne badania obrazowe umożliwiły postawienie właściwego rozpoznania i usunięcie ciała obcego drogą torakotomii lewostronnej.

  3. Fundamentos bioquímicos de la inmunotoxicología de los opiáceos

    Directory of Open Access Journals (Sweden)

    Guillermo Orlando Narváez Quintero

    2009-07-01

    Full Text Available Se ha descubierto que la morfina, anteriormente conocida como una sustancia de origen vegetal extraída de la amapola, es sintetizada también por el cuerpo humano y hace parte del sistema opioide endógeno. La morfina endógena está involucrada en la regulación negativa del sistema inmune, regresándolo a sus condiciones basales luego de haber sido activado. Las investigaciones experimentales preclínicas y clínicas han mostrado que la administración de morfina conduce a efectos inmunosupresores, inhibiendo la actividad de las células asesinas naturales, la proliferación linfocitaria y la capacidad fagocítica de los polimorfonucleares y monocitos. Adicionalmente esta sustancia altera el patrón de síntesis, secreción y actividad paracrina de citocinas, favoreciendo así la respuesta inmune mediada por anticuerpos (Th2-dependiente e inhibiendo la respuesta inmune mediada por células (Th1-dependiente. Estos efectos son suprimidos por la naloxona, un antagonista de los receptores m. Al parecer la morfina actúa a través de una nueva variante del receptor m de péptidos opioides denominado m3, presente en la superficie de las células inmunocíticas. Llama la atención la similitud entre los efectos inmunotóxicos generados en adictos al opio, VIH negativos, con aquellos observados en pacientes no drogadictos VIH positivos que progresan hacia sida.

  4. Kiła układu nerwowego jako trudny problem w codziennej praktyce klinicznej – opis przypadku

    Directory of Open Access Journals (Sweden)

    Karolina Mędrek

    2011-07-01

    Full Text Available Introduction. Syphilis still represents an important clinical problem.Involvement of the nervous system is one of the major features of latesyphilis, but may also occur in early syphilis.Objective. To present a case of neurosyphilis in relation to the currentproblems of diagnostics and therapy of Treponema pallidum infection.Case report. We present a 31-year-old woman with neurosyphilis. Atthe beginning the patient was treated with erythromycin, and twelvemonths later, because of insufficient decrease of titre of syphilis tests inthe serum, with doxycycline. Despite the second therapy the titres ofsyphilis tests remained high and therefore after another nine monthsthe patient was referred to our department for further diagnostics andtreatment. Because of the long course of the disease, high titres ofsyphilis tests in the serum and abnormalities in neurological examination(hypoaesthesia below the Th8 level, foot clonus and hyporeflexiain lower extremities T. pallidum neuroinfection was suspected andcerebrospinal fluid was collected. The serological examination of cerebrospinalfluid revealed positive treponemal tests (FTA 1 : 10, TPHA++, while VDRL was negative. Based on the whole clinical presentationand laboratory abnormalities, neurosyphilis was diagnosed andtherapy with crystalline penicillin followed by procaine penicillin wasperformed.Conclusions. Neurosyphilis is characterized by rich symptomatologyand its diagnosis based only on clinical manifestation can be very difficult;particularly subtle symptoms may be easily overlooked. Therefore,evaluation of cerebrospinal fluid is necessary in all questionablepatients in order to establish a correct diagnosis.

  5. O-pi e-de-i: on round building as an archetypical form of sacred space in the Aegean

    Directory of Open Access Journals (Sweden)

    Evyenia Yiannouli

    2011-12-01

    Full Text Available The archaeological record supports the general proposition that the simplest form of architecture, the round building type, variously persisted throughout the Aegean prehistory. This paper makes a case for the identification of round building as a distinct genre of sacred space in the Aegean Bronze Age, Mycenaean Crete in particular, combining evidence from architecture, iconography and the scripts. Certain archetypical features are thus delineated. It is argued that the historical understanding of the emerging LBA state requires a study of the architecture prior to the 2nd millennium BC as much as other relevant evidence issuing from the latest Aegean strata.

  6. Description of the control and safety systems of the RA reactor; Opis sistema za upravljanje i sigurnosnu zastitu RA

    Energy Technology Data Exchange (ETDEWEB)

    Popovic, B; Pesic, M [Institute of Nuclear Sciences Boris Kidric, Reaktor RA, Vinca, Beograd (Yugoslavia)

    1962-07-01

    This report contains detailed description and scheme of the control and safety system of the RA reactor. It consists of interconnected five systems: for automated regulation; compensation rods; safety rods; power density measurement device; period meter; automated D{sub 2}O level meter in the core. Automated regulation system is divided into two parts: basic system for reactor operation regime at power from 10kW - 10 MW and precise regulation system for operation at set-up power level up to 10 kW which is used occasionally.

  7. Trądzik odwrócony leczony operacyjnie innowacyjnymi technikami redukcji powstałych ubytków – opis przypadku

    Directory of Open Access Journals (Sweden)

    Andrzej Bieniek

    2011-11-01

    Full Text Available Introduction. Acne inversa is a recurrent, suppurative disease manifestedby abscesses, fistulas and scarring.Many conservative therapies areusually disappointing, and an early surgical intervention often remainsthe only successful treatment. This condition has a significant impact onthe quality of the patient’s life; therefore there is a need for introductionof effective therapeutic modalities at every stage of the disease.Objective. Presentation of two innovative techniques of wound closureafter surgical excision of the affected skin areas.Case report. A 42-year-old female patient suffering from acne inversa,treated previously with ineffective methods based on a conservativeapproach, was operated on with the use of tumescent infiltration anaesthesiaand our own surgical techniques such as the “star-like” and“pubic flaps” techniques.Conclusions. Presented data show unequivocally that our own methodsof surgical wound closure are highly effective and that a patientwith acne inversa can tolerate it well. We encourage the use of thesetechniques, but choosing the best option requires an individualapproach.

  8. Design project SP-RA, Construction specifications of the sanitary corridor - SP building; Idejni projekat SP-RA, Gradjevinski opis sanitarnog propusnika - objekat

    Energy Technology Data Exchange (ETDEWEB)

    Bon, B [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1956-11-09

    According to the design task the sanitary corridor satisfies the needs of both RA reactor and HL (Hot laboratory) buildings. This building is located between RA and HL buildings and is connected to both by corridors 3,3 m wide. The access to the building is from the south, i.e. from the local road in the Vinca Institute. [Serbo-Croat] Prema projektnom zadatku sanitarni propusnik zadovoljava potrebe objekata RA i HL. Zgrada je situirana izmedju ova dva objekta. Sa objektima RA i HL vezana je komunikativnim hodnikom sirine 3,3 m. Prilaz zgradi je sa juzne strane, odnosno sa internog puta Instituta Vinca.

  9. Zespół Noonan u 8-letniej pacjentki – opis przypadku = 8 - year - old patient with Noonan syndrome - case report

    Directory of Open Access Journals (Sweden)

    Aleksandra Grabiec

    2016-12-01

    Kierownik: dr hab. n. med. prof. nadzw. Anna Janas-Naze               Adres do korespondencji: Aleksandra Szczepkowska Zakład Chirurgii Stomatologicznej UM w Łodzi 92-213 Łódź, ul. Pomorska 251 e-mail: aleksandra.szczepkowska@gmail.com tel. 42 675 75 71           Praca finansowana przez Uniwersytet Medyczny w Łodzi w ramach działalności statutowej nr 503/2-163-01/503-21-001       Streszczenie: W poniższej pracy opisano przypadek zespołu Noonan u 8- letniej dziewczynki.   Słowa kluczowe: zespół Noonan, rzadkie choroby genetyczne, znieczulenia ogólne     Abstract: The article presents the case of 7 year old girl with Noonan syndrome.   Key words: Noonan syndrome, rare genetic diseases, general anesthesia

  10. Martwica kości szczęk związana ze stosowaniem bifosfonianów. Opis przypadków

    Directory of Open Access Journals (Sweden)

    Wojciech Leśniak

    2013-06-01

    Full Text Available Bifosfoniany należą do silnych inhibitorów osteoklastów. Znajdują szerokie zastosowanie w leczeniu chorób przebiegających ze wzmożoną resorpcją kości: osteoporozy, choroby Pageta i osteogenesis imperfecta. Leki te zmniejszają adhezję komórek nowotworowych do kości, ograniczają osteolizę wywołaną nowotworem i hiper‑ kalcemię. Zmniejszają dolegliwości bólowe w szpiczaku mnogim i w przerzutach do kości. Powszechnie panu‑ jące przekonanie o bezpieczeństwie spowodowało rozszerzenie wskazań do ich stosowania. Pacjenci onkolo‑ giczni przyjmujący bifosfoniany dożylnie, w wysokich dawkach są bardziej narażeni na działania niepożądane terapii niż pacjenci przyjmujący je doustnie. Jednym z najpoważniejszych powikłań jest martwica kości szczęk. W 2003 roku opisano po raz pierwszy związek pomiędzy terapią bifosfonianami a martwicą kości szczęk. W piśmiennictwie znajdujemy coraz więcej przykładów tego działania niepożądanego, także po stosowaniu leków doustnie. Mogą pojawiać się ból, obrzęk, owrzodzenie, odsłonięcie kości, przetoki, złamania patologiczne, uciążliwe dla pacjenta i obniżające jakość życia. Leczenie martwicy kości szczęk jest trudne i rzadko przynosi spodziewany efekt. Główną rolę odgrywa leczenie zachowawcze i redukcja objawów. Odstawienie bifosfonia‑ nów nie ma bezpośredniego wpływu na przebieg martwicy kości szczęk, ze względu na kumulację leku w kości. Istotne jest przygotowanie pacjenta przed rozpoczęciem podawania bifosfonianów, wymagające stałej współ‑ pracy pomiędzy lekarzami onkologami, ortopedami i chirurgami szczękowo-twarzowymi. Higiena jamy ustnej i leczenie chorób współistniejących stanowi ważny element postępowania. Celem pracy jest przedstawienie trzech przypadków martwicy kości szczęk u pacjentów poddanych leczeniu bifosfonianami.

  11. Interacción analgésica entre antiinflamatorios no esteroideos (AINES) y opiáceos durante la anestesia inhalatoria en la rata

    OpenAIRE

    Benito de la Víbora, Javier

    2016-01-01

    La reducción de las necesidades de anestésicos inhalatorios mediante la coadministración de analgésicos intraoperatorios conlleva un incremento del margen de seguridad del paciente pero también una disminución de la polución ambiental y una reducción de costes. La combinación de diferentes tipos de analgésicos puede incrementar dicho efecto ahorrador de anestésico e incluso se ha observado un efecto potenciador derivado de la administración conjunta con de inhibidores de la ciclooxigenasa (CO...

  12. Endometrioza o potrójnej lokalizacji: w przegrodzie odbytniczo-pochwowej, w bliźnie po cięciu cesarskim oraz w jajniku – opis przypadku

    Directory of Open Access Journals (Sweden)

    Andrzej Skręt

    2011-10-01

    Full Text Available The authors discuss the symptoms, pathogenesis and treatment of endometriosis of multiple localization:in the recto-vaginal septum, in a post-caesarean scar and in the ovary. In the available literature we found nodata on the prevalence of endometriosis in triple localisation. The authors discuss symptoms, pathogenesis andtreatment of endometriosis concerning the described localisation.

  13. Interakce N-terminálního zbytku kyseliny myristové s matrixovým proteinem Mason-Pfizerova opičího viru

    Czech Academy of Sciences Publication Activity Database

    Prchal, J.; Doležal, M.; Vlach, J.; Lipov, J.; Rumlová, Michaela; Hunter, E.; Ruml, T.; Hrabal, P.

    2009-01-01

    Roč. 103, č. 5 (2009), s. 446-446 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků. Konference Sigma-Aldrich /9./. 26.05.2009-29.05.2009, Devět skal - Žďárské vrchy] R&D Projects: GA MŠk(CZ) 1M0520 Grant - others:GA ČR(CZ) GA203/07/0872 Institutional research plan: CEZ:AV0Z40550506 Keywords : retroviruses * matrix protein * myristic acid Subject RIV: CE - Biochemistry

  14. Męska depresja – koncepcja, metody pomiaru i związki z zachowaniami samobójczymi

    Directory of Open Access Journals (Sweden)

    Jan Chodkiewicz

    2016-03-01

    Full Text Available W artykule przedstawiono koncepcję atypowych objawów depresji występujących u mężczyzn. Ważnym źródłem tej koncepcji były doświadczenia wyniesione z programu diagnozowania i leczenia depresji wprowadzonego na Gotlandii (Szwecja w latach 80. ubiegłego stulecia. Program, skierowany do lekarzy rodzinnych, zmniejszył liczbę zachowań samobójczych wśród kobiet, ale nie wśród mężczyzn. Przyjęto, że jedną z przyczyn takiego stanu rzeczy może być odmienny obraz depresji u obu płci. Różnice między płciami mogą odpowiadać za to, że depresja u mężczyzn znacznie częściej niż u kobiet pozostaje nierozpoznana i nieleczona, co prowadzi do zwiększenia liczby samobójstw. Wśród dominujących objawów depresji u mężczyzn wyróżniono wzrost impulsywności i zachowań agresywnych, nadużywanie substancji psychoaktywnych (alkohol, narkotyki, nikotyna, podejmowanie zachowań ryzykownych (jazda samochodem pod wpływem alkoholu, przypadkowe kontakty seksualne oraz tłumienie emocji. Jako przyczyna występowania atypowej depresji u mężczyzn najczęściej wymieniane jest rygorystyczne podporządkowywanie się tradycyjnym męskim normom kulturowym. Normy te dotyczą odporności, wytrzymałości, konkurowania, opanowania i tłumienia uczuć oraz konieczności zapewnienia bytu rodzinie. W pracy omówiono najbardziej znane metody badania męskiej depresji – Gotland Male Depression Scale (GMDS Rutza, Male Depression Risk Scale (MDRS-22 Rice’a i współpracowników oraz Masculine Depression Scale (MDS Magovcevic i Addisa – a także przedstawiono wyniki badań prowadzonych z użyciem wspomnianych metod. Artykuł kończą refleksje dotyczące dalszych kierunków badań nad problemem męskiej depresji i opis kontrowersji związanych z omawianą koncepcją.

  15. Postępowanie diagnostyczno-terapeutyczne u pacjenta po skręceniu stawu skokowego – opis przypadku = The diagnosis and therapy in a patient after ankle sprains – case report

    Directory of Open Access Journals (Sweden)

    Jan Paweł Mieszkowski

    2016-08-01

    Streszczenie Wstęp: Skręcenia stawu skokowego zaliczane są do jednych z najczęściej spotykanych urazów kończyn dolnych. Pomimo częstości występowania, nadal wielokrotnie są one lekceważone, zarówno w aspekcie diagnostyki medycznej jak i zastosowania optymalnego postępowania leczniczego. Cel pracy: Usystematyzowanie wiedzy na temat postępowania terapeutycznego, u osoby po urazie stawu skokowego. Celem dodatkowym była analiza postępowania fizjoterapeutycznego oraz jego efektywności u pacjenta po skręceniu stawu skokowego. Metoda: W pracy przedstawiono epikryzę pacjenta z urazem stawu skokowego. Pacjent poddany był dwukrotnie diagnostyce klinicznej. Wykonano analizę chodu, ocenę zakresu ruchu w stawie skokowym, ocenę siły mięśniowej kończyn dolnych przy pomocy skali Lovette’a, testy funkcjonalne stopy (test uciskowy Thompsona, test Simmonda, test szufladki, test dwóch wag. Zastosowano metody zewnętrznej stabilizacji przy pomocy szyny gipsowej, metodę twardych tapów, a także terapię układu limfatycznego z wykorzystaniem metody kinesiology taping i drenażu limfatycznego. Wraz z ustąpieniem zmian obrzękowych, pacjenta poddano kompleksowej terapii fizjoterapeutycznej. Wyniki: Po zakończeniu terapii chód - izochroniczny, izometryczny, izotoniczny, poprawa w zakresie: ruchu w stawie skokowym dla zgięcia grzbietowego, podeszwowego, pronacji, supinacji stopy, wyniku testu dwóch wag oraz siły mięśniowej. Wnioski: W postępowaniu terapeutycznym u osoby po urazie stawu skokowego najważniejszą rolę odegrała diagnostyka radiologiczna i kliniczna, pozwalająca na postawienie wczesnej i właściwej diagnozy. Kompleksowe postępowanie fizjoterapeutyczne wpłynęło na poprawę zakresu ruchu w stawie skokowym, zniesienie dolegliwości bólowych oraz na poprawę stanu funkcjonalnego badanego.

  16. The role of brain magnetic resonance imaging in the diagnosis of pantothenate kinase deficiency (previously Hallervorden-Spatz disease): case report; Znaczenie badania tomografii rezonansu magnetycznego mozgowia w diagnostyce deficytu kinazy pantotenowej (dawniej choroby Hallervordena-Spatza) - opis przypadku

    Energy Technology Data Exchange (ETDEWEB)

    Gizewska, M; Bieleninik, A; Adamczyk, T; Walczak, M [II Klinika Chorob Dzieci Pomorskiej Akademii Medycznej, Szczecin (Poland); Cyrylowski, L [Zaklad Diagnostyki Obrazowej i Radiologii Interwencyjnej Pomorskiej Akademii Medycznej, Szczecin (Poland); Abramczyk, G [Oddzial Noworodkow, Patologii i Intensywnej Terapii, Samodzielnego Publicznego Specjalistycznego ZOZ ' ' Zdroje ' ' , Szczecin (Poland); Nowacki, P [Klinika Neurologii Pomorskiej Akademii Medycznej, Szczecin (Poland)

    2005-07-01

    Panthotenate kinase deficiency is a rare metabolic disorder from the group of neuroaxonal dystrophy. It is characterized by symptoms of extrapiramidal system impairment, general dystonia, progressive gait disturbances, limbs rigidity, dyskinesias, choreoatetotic movements, dysarthria and progressive dementia. On the brain MRI, T2 - weighted images demonstrate typical, symmetrical '' eye of the tiger '' sign with hyperintensive signals from the central parts of the pallidum, surrounded by low signals in the pallidum and accompanied by hypointensity in substantia nigra resulting from iron deposition. We present a case of 13.5 year old boy with gait disturbances, increase muscles tone, dysartria, aggressive behavior and learning difficulties progressing from the early childhood. In the differential diagnosis a number of inborn errors of metabolism was excluded. Finding on the brain MRI in T2- weighted images typical picture of '' eye of the tiger '' led to a diagnosis of panthotenate kinase deficiency. In subsequent years of observation, despite attempts of baclofen and calcium panthotenate treatment, progression of pyramidal-extrapyramidal syndrome is observed. In children with symptoms of progressive extrapyramidal tract impairment, a sign of '' eye of the tiger '' with hyperintensive signals from the central parts of the pallidum, surrounded by low signals in the remaining part of the pallidum and accompanied by similar lesions in substantia nigra is typical for panthotenate kinase deficiency - a rare neurodegenerative disorder of central nervous system. (author)

  17. Zmiany wybranych wskaźników i cech gazometrii krwi w okresie fizjologicznej restytucji po wysiłku wytrzymałościowym mężczyzny w 6 dekadzie życia. Opis przypadku

    Directory of Open Access Journals (Sweden)

    Mirosław Mrozkowiak

    2015-07-01

    • Należy przyjąć, że wskaźnik aktualnego nadmiaru zasad i stężenia jonów wodorowęglanowych wymaga dłuższego okresu normalizacji niż 54 godzina restytucji późnej.   Abstract Introduction. Rest meaning is dynamically variable physiological state of the body, immediately following the completion or reducing the intensity of physical or mental. During this period, dominated by the processes of assimilation over dissimilation. The decline of physical performance in older extent be explained by the deterioration of muscle perfusion during exercise. Its causes should be sought in anatomical changes occurring both in the myocardium, as well as blood vessels. The aim of the study is to demonstrate the changes in selected indicators and characteristics of blood gases during the period of physiological restitution after exercise endurance for a man in 6 decade of life. Materials and methods. Tested man pursuing a healthy lifestyle surrendered to the designation of selected indicators of blood after exercise endurance during spontaneous restitution pH, PCO2, PO2, BB, BE, BEart,cHCO3, SO2(c. Obtained results. Positive results were observed in most measured rates and characteristics of blood gases. At the same time differently they presented their configuration during the 5-day measurement cycle. The most positive changes were observed in the size of BB, BE, PCO2. Conclusions 1. During the early restitution after exercise endurance in a 61 year old male normalization is: systolic and diastolic arterial blood pressure, heart rate, the partial pressure of carbon dioxide, the principle of buffering plasma, state principles (excess / deficiency. In the late restitution: oxygen saturation, partial pressure of oxygen. 2. It is assumed that the current rate of excess bases and bicarbonate ion concentration requires a longer period of normalization than 54 hours restitution of late.

  18. A influência dos analgésicos não opióides e antiinflamatórios não-esteróides no movimento ortodôntico

    OpenAIRE

    Berthold, Telmo Bandeira; Ferreira, Patricia; Berthold, Roger Correa de Barros

    2012-01-01

    O movimento dentário durante o tratamento ortodôntico requer uma remodelação do osso alveolar e dos tecidos periodontais. Para a movimentação dentária, osteoclastos devem ser formados de modo que possam remover osso da área adjacente à parte comprimida do ligamento periodontal, e também é necessária a formação de osteoblastos para a produção de novo osso no lado de tensão e nas áreas de reabsorção remodeladora no lado de pressão. As prostaglandinas têm a importante propriedade de estimular ta...

  19. Opis leksykograficzny syntaktycznych i semantycznych cech czasowników w języku czeskim, polskim i rosyjskim. Na przykładzie czasowników percepcji

    Czech Academy of Sciences Publication Activity Database

    Skwarska, Karolína

    2015-01-01

    Roč. 67, č. 1 (2015), s. 349-366 ISSN 0138-0567 R&D Projects: GA ČR GAP406/12/0557 Institutional support: RVO:68378017 Keywords : valency * valency lexicon * verbs of perception * alternation * comparative syntax Subject RIV: AI - Linguistics

  20. Analgesia peridural para o trabalho de parto e para o parto: efeitos da adição de um opióide Effects of the association of an opioid with epidural analgesia for labor and delivery

    Directory of Open Access Journals (Sweden)

    José Guilherme Cecatti

    1998-07-01

    Full Text Available O objetivo deste estudo foi avaliar a eficácia e segurança da associação bupivacaína com sufentanil para a analgesia no trabalho de parto e do parto por meio de um bloqueio peridural contínuo. Realizou-se um ensaio clínico duplo-cego, prospectivo e aleatório, incluindo sessenta mulheres nulíparas da Maternidade do CAISM/UNICAMP. No momento da analgesia, as mulheres foram aleatoriamente alocadas em dois grupos: BS, recebendo 12,5 mg de bupivacaína com adrenalina mais 30 µg de sufentanil e BP, recebendo 12,5 mg de bupivacaína com adrenalina mais placebo. Foram avaliados os parâmetros relativos à qualidade e duração da analgesia, duração do trabalho de parto e também possíveis efeitos sobre o recém-nascido. Os resultados mostraram a superioridade da adição do sufentanil sobre o grau de analgesia durante o tempo de ação da primeira dose de anestésico local. Não houve aumento na duração do trabalho de parto depois do início da analgesia quando se compararam ambos os grupos, nem qualquer diferença quanto à via de parto. Não houve também diferenças entre os grupos com relação à avaliação dos recém-nascidos. Conclui-se que a associação de 30 µg de sufentanil à primeira dose de bupivacaína é segura e eficaz, melhorando a qualidade da analgesia, sua duração e não afetando a progressão do trabalho de parto e o resultado neonatal.The purpose of the present study was to evaluate the efficacy and safety of the association bupivacaine with sufentanil for labor and delivery analgesia through a continuous epidural blockade, for both mother and the neonate. A randomized double blind prospective clinical trial was performed including sixty nulliparous women at the Maternity of CAISM/UNICAMP. When requesting analgesia, the women were randomly allocated to two groups: BS, receiving 12.5 mg of bupivacaine with adrenaline plus 30 µg of sufentanil and BP, receiving 12.5 mg of bupivacaine with adrenaline plus placebo. The parameters concerning the quality and duration of analgesia, duration of labor, and also possible effects on the neonate were evaluated. The results showed the superiority of the addition of sufentanil regarding the degree of analgesia during the time of action of the first dose of the local anesthetic. There was no increase in the duration of labor after the onset of analgesia when comparing both groups, nor any difference in the route of delivery. Concerning neonate evaluation, there were no differences between the two groups. It is concluded that the association of 30 µg of sufentanil with the first dose of bupivacaine is safe and efficacious. It improved the quality of analgesia, increased its duration, and did not affect the progress of labor and neonatal outcome.

  1. Effects of Limited Hydrolysis and High-Pressure Homogenization on Functional Properties of Oyster Protein Isolates.

    Science.gov (United States)

    Yu, Cuiping; Cha, Yue; Wu, Fan; Xu, Xianbing; Du, Ming

    2018-03-22

    In this study, the effects of limited hydrolysis and/or high-pressure homogenization (HPH) treatment in acid conditions on the functional properties of oyster protein isolates (OPI) were studied. Protein solubility, surface hydrophobicity, particle size distribution, zeta potential, foaming, and emulsifying properties were evaluated. The results showed that acid treatment led to the dissociation and unfolding of OPI. Subsequent treatment such as limited proteolysis, HPH, and their combination remarkably improved the functional properties of OPI. Acid treatment produced flexible aggregates, as well as reduced particle size and solubility. On the contrary, limited hydrolysis increased the solubility of OPI. Furthermore, HPH enhanced the effectiveness of the above treatments. The emulsifying and foaming properties of acid- or hydrolysis-treated OPI significantly improved. In conclusion, a combination of acid treatment, limited proteolysis, and HPH improved the functional properties of OPI. The improvements in the functional properties of OPI could potentiate the use of oyster protein and its hydrolysates in the food industry.

  2. A novel Interactive Health Communication Application (IHCA) for parents of children with long-term conditions: Development, implementation and feasibility assessment.

    Science.gov (United States)

    Swallow, Veronica; Carolan, Ian; Smith, Trish; Webb, Nicholas J A; Knafl, Kathleen; Santacroce, Sheila; Campbell, Malcolm; Harper-Jones, Melanie; Hanif, Noreen; Hall, Andrew

    2016-01-01

    Few evidence-based, on-line resources exist to support home-based care of childhood long-term conditions. In a feasibility study, children with stages 3, 4, or 5 chronic kidney disease, parents and professionals collaboratively developed a novel Online Parent Information and Support (OPIS) application. Parents were randomized to an intervention arm with access to OPIS or a control arm without access. OPIS usage was assessed using Google Analytics. Parents in the intervention arm completed the Suitability Assessment of Materials (SAM) and User Interface Satisfaction (USE) questionnaires and participated in qualitative interviews. Twenty parents accessed OPIS with a mean of 23.3 (SD 20.8, range 2-64) visits per user. Responses from the SAM and USE questionnaires were positive, most respondents rating OPIS highly and finding it easy to use. Qualitative suggestions include refinement of OPIS components, enabling personalization of OPIS functionalities and proactive endorsements of OPIS by professionals. Implementation of OPIS into standard practice is feasible in the centre where it was developed. Suggested developments will augment reported strengths to inform ongoing testing in the wider UK network of units. Our design and methods are transferrable to developing and evaluating web-applications to support home-based clinical care-giving for other long-term conditions.

  3. Characterization of Saccharomyces cerevisiae suppressor mutants devoid of the membrane lipid phosphatidylcholine

    NARCIS (Netherlands)

    Bao, X.

    2018-01-01

    Phosphatidylcholine (PC) is the most abundant membrane lipid in most eukaryotes and considered essential. The yeast double deletion mutant cho2opi3 lacks the methyltransferases converting phosphatidylethanolamine (PE) to PC. As a consequence, the cho2opi3 mutant is a choline auxotroph that relies on

  4. RAPD-PCR analysis of cultured type olives in Turkey | Sesli | African ...

    African Journals Online (AJOL)

    OP-A, OP-I, OP-Q). A total of 33 primers among 60 Operon random primers (Kit OP-A, OP-I, OP-Q) yielded clear and firm bands. The electrophoretic patterns of olive samples showed that 159 highly polymorphic loci. Averages of 4.81 scorable ...

  5. Development of EPICS channel access embedded ActiveX components for GUI development

    International Nuclear Information System (INIS)

    Roy, A.; Bhole, R.B.; Pal, S.

    2012-01-01

    The paper describes the integration of Experimental Physics and Industrial Control System (EPICS) Channel Access (CA) protocol and Microsoft ActiveX technology towards developing a generalize operator interface (OPI) building facility for Windows platform. EPICS is used as the development architecture of the control system in Superconducting Cyclotron (SCC). Considering the operators' familiarity and compatibility with third party software, it was decided to use MS-Windows platform at operator interface level in SCC during commission. Microsoft Visual Basic (VB) is used on trial basis as OPI building platform to incorporate user specific features e.g. file system access for data storage and analysis, user authentication at OPI level etc. A set of EPICS Channel Access embedded ActiveX components is developed to ease the programming complexity and reduce developmental time of the OPI for Windows platform. OPIs, developed using these components and containing hundreds of process parameters, are being used reliably over a considerable period of time. (author)

  6. Potential rapd markers for population studies in tree legumes

    International Nuclear Information System (INIS)

    Gomez, S.M.; Ramasubramanian, T.; Mohankumar, S.

    2011-01-01

    RAPDs were quite efficient in bringing out the diversity at DNA level among non-edible legumes viz., Acacia nilotica, Adenanthera pavonina, Prosopis juliflora, Pithecolobium dulce, Clitoria ternatea and Pongamia pinnata. The RAPD primer index reveals the information content of the RAPD primer per se. Of the 82 primers tested, OPE 8, OPI 6, OPL 2, OPL 16, OPI 18, OPI 13, OPI 14, OPP 1, OPE 20 and OPI 4 with comparatively higher primer index were more informative and can be used for further DNA finger printing and population studies in tree legumes. CTAB protocol was found to be superior in isolating genomic DNA of good quality. The 260/280 ratios varied between 1.70 and 2.09. Though the genomic DNA isolated by potassium acetate method was found to be intact in 0.8% agarose gel, the yield was significantly lower than the modified CTAB method. (author)

  7. Confecção de um modelo experimental in vitro do espaço subaracnóide eqüino para teste de opióides hiperbáricos Making of an in vitro experimental model of equine subarachnoid space to test hyperbaric opioids

    Directory of Open Access Journals (Sweden)

    Alexandre da Silva Polydoro

    2008-04-01

    Full Text Available Com o objetivo de avaliar as características de distribuição de agentes hiperbáricos no líquido cérebro-espinhal (LCE eqüino, é apresentado um modelo in vitro do espaço subaracnóide confeccionado em policloreto de vinila (PVC transparente, no qual se adaptou um cateter para a infusão contínua de glicose a 10%, morfina hiperbárica, buprenorfina hiperbárica e metadona hiperbárica marcadas com azul de metileno para permitir a visualização da distribuição destas substâncias no LCE. Avaliaram-se a distância alcançada pelos diferentes agentes minuto a minuto e a forma de distribuição dos mesmos. Todas as substâncias testadas mostraram comportamento de distribuição vertical a partir da extremidade do cateter, quando se deu o início da migração cranial no LCE, sendo que o avanço máximo registrado foi aos 15 minutos após o término da infusão, com migração de 15cm para glicose a 10%, 13cm para a morfina hiperbárica, 18cm para a buprenorfina hiperbárica e 17cm para a metadona hiperbárica. O modelo proposto mostrou-se eficiente para a avaliação do comportamento físico dos agentes hiperbáricos no interior do espaço subaracnóide, oferecendo a possibilidade de teste de substâncias a serem utilizadas pela via subaracnóide de cavalos.The aim of this study was to evaluate the distribution characteristics of hyperbaric solutions in equine cerebrospinal fluid (CSF, in an in vitro model of the subarachnoid space. The model was made with transparent PVC in which a catheter was adapted to infuse 10% glucose, 10% hyperbaric morphine, hyperbaric buprenorphine, and hyperbaric methadone, dyed with methilene blue in order to visualize the solutions distribution in the CSF. The distance in cm reached by the different agents every minute as well as the pattern of distribution were evaluated. All tested solutions distributed itself in a forward and vertically pattern from the tip of the catheter. Maximum distance reached after 15 minutes were 15cm for 10% glucose, 13cm for hyperbaric morphine, 18cm for hyperbaric buprenorphine, and 17cm for hyperbaric methadone. The proposed model was efficient to evaluate the distribution pattern of hyperbaric solutions in equine CSF, offering a new possibility to physically test the administration of solutions in the equine subarachnoid space.

  8. Estudios sobre el papel del área tegmental ventral y de las regiones dopaminérgicas rostral lineal y periacueductal del mesencéfalo en la adicción y analgesia opiáceas en ratas

    OpenAIRE

    Flores Cordero, Juan Antonio

    2005-01-01

    Falta por incorporar las palabras clave El número medio de cada tipo celular fue de 129,431,3 células grandes de la PAG ventrolateral, 305,843,5 células periacueductales de la PAG y 1441,4210 células pequeñas de la región RLi/PAG ventral. 3. En las neuronas dopamimérgicas grandes de la PAG y pequeñas de la región Rli/PAG ventral (pero no en las periacueductales) se produce una regulación al alza en la expresión de TH tras el tratamiento repetido y subcutáneo con heroína. 4. La infusión del...

  9. Vyšetřování vybraných steroidogenních enzymů v lidských a opičích mozkových tkáních

    Czech Academy of Sciences Publication Activity Database

    Kříž, L.; Mohapl, M.; Černý, Ivan; Pouzar, Vladimír; Bičíková, M.; Hill, M.

    2003-01-01

    Roč. 97, č. 11 (2003), s. 1115 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /38./. 28.11.2003-30.11.2003, Nymburk] R&D Projects: GA ČR GA203/02/1440 Institutional research plan: CEZ:AV0Z4055905 Keywords : dehydroepiandrosterone * sulfotransferase Subject RIV: CC - Organic Chemistry

  10. Role bazické oblasti nukleokapsidového proteinu Masonova-Pfizerova opičího viru během skládání nezralých retrovirových částic

    Czech Academy of Sciences Publication Activity Database

    Dostálková, A.; Hadravová, Romana; Rumlová, M.

    2016-01-01

    Roč. 14, č. 2 (2016), s. 58-59 ISSN 2336-7202. [Mezioborové setkání mladých biologů, biochemiků a chemiků /16./. 10.05.2016-13.05.2016, Milovy] R&D Projects: GA ČR(CZ) GA14-15326S Institutional support: RVO:61388963 Keywords : M-PMV * Mason-Pfizer monkey virus * nucleocapsid protein Subject RIV: EE - Microbiology, Virology

  11. Readability of Online Patient Educational Resources Found on NCI-Designated Cancer Center Web Sites.

    Science.gov (United States)

    Rosenberg, Stephen A; Francis, David; Hullett, Craig R; Morris, Zachary S; Fisher, Michael M; Brower, Jeffrey V; Bradley, Kristin A; Anderson, Bethany M; Bassetti, Michael F; Kimple, Randall J

    2016-06-01

    The NIH and Department of Health & Human Services recommend online patient information (OPI) be written at a sixth grade level. We used a panel of readability analyses to assess OPI from NCI-Designated Cancer Center (NCIDCC) Web sites. Cancer.gov was used to identify 68 NCIDCC Web sites from which we collected both general OPI and OPI specific to breast, prostate, lung, and colon cancers. This text was analyzed by 10 commonly used readability tests: the New Dale-Chall Readability Formula, Flesch Reading Ease scale, Flesch-Kinaid Grade Level, FORCAST scale, Fry Readability Graph, Simple Measure of Gobbledygook test, Gunning Frequency of Gobbledygook index, New Fog Count, Raygor Readability Estimate Graph, and Coleman-Liau Index. We tested the hypothesis that the readability of NCIDCC OPI was written at the sixth grade level. Secondary analyses were performed to compare readability of OPI between comprehensive and noncomprehensive centers, by region, and to OPI produced by the American Cancer Society (ACS). A mean of 30,507 words from 40 comprehensive and 18 noncomprehensive NCIDCCs was analyzed (7 nonclinical and 3 without appropriate OPI were excluded). Using a composite grade level score, the mean readability score of 12.46 (ie, college level: 95% CI, 12.13-12.79) was significantly greater than the target grade level of 6 (middle-school: Preadability metrics (P<.05). ACS OPI provides easier language, at the seventh to ninth grade level, across all tests (P<.01). OPI from NCIDCC Web sites is more complex than recommended for the average patient. Copyright © 2016 by the National Comprehensive Cancer Network.

  12. Dynamic risk assessment method – a proposal for assessing risk in water supply system / Metoda dynamicznego szacowania ryzyka – propozycja oceny ryzyka w systemie zaopatrzenia wody

    OpenAIRE

    Fortmann-Roe Scott; Iwanejko Ryszarda; Wójcik Włodzimierz

    2015-01-01

    Dynamika Systemów jest metodologią modelowania i analizy złożonych systemów. Taki złożony system może być charakteryzowany przez wzajemne proste połączenia elementów oraz istniejące sprzężenia zwrotne. Przeprowadzenie oceny ryzyka przy modelowaniu Systemów Dynamicznych jest trudnym wyzwaniem. Chociaż w niektórych przypadkach, uzyskane za pomocą symulacji serie wyników mogą się wydawać przypadkowe, to jednak często istnieje wysoki stopień autokorelacji między tymi seriami wynikający z istnieni...

  13. SAMOOSKRBA GOSPODINJSKEGA ODJEMA S SONČNO ELEKTRARNO IN BATERIJSKIM SISTEMOM

    OpenAIRE

    VIDMAJER, DAVID

    2016-01-01

    Diplomsko delo opiše in analizira otočno delovanje stanovanjskega objekta za štiričlansko družino z izbiro primerne sončne elektrarne, litij-ionskih baterij in dizelskega agregata (off-grid system). V diplomski nalogi smo na kratko predstavili problematiko delovanja sončne elektrarne, delovanje otočnega sistema in elemente, ki so nujni za njegovo obratovanje, ter opis in delovanje baterij. Sledi opis enačb za modeliranje komponent otočnega sistema, po kateremu principu smo naredili tudi nadal...

  14. Potresna analiza in analiza ojačitvenih ukrepov za grad Golnik

    OpenAIRE

    Ošterbenk, Jure

    2015-01-01

    V diplomskem delu je narejena seizmična analiza gradu Golnik in primerjalna študija ojačitvenih ukrepov, s katerimi povečujemo potresno odpornost obravnavane konstrukcije. Po začetnem kronološkem opisu stavbe sledi opis zasnove objekta in opis stanja poškodovanosti nosilnih elementov, ki temelji zgolj na vizualnem pregledu konstrukcije. V teoretičnem delu naloge je sprva na kratko predstavljeno obnašanje zidanih stavb med delovanjem potresa in opis različnih porušnih mehanizmov zidovja. Sl...

  15. Síntese, caracterização e estudo das propriedades magnéticas de um polímero de coordenação contendo cobalto(II e cobre(II

    Directory of Open Access Journals (Sweden)

    Tamyris T. da Cunha

    2012-01-01

    Full Text Available This work describes the synthesis and characterization of two new compounds with ligand opy (N-(2-pyridyloxamate: the copper(II precursor [Me4N]2[Cu(opy2].5H2O and CoII CuII coordination polymer {[CoCu(opy2]}n×4nH2O. This latter compound was obtained by reaction of [Me4N]2[Cu(opy2].5H2O and CoCl2.6H2O in water. The heterobimetallic CoII CuII chain was characterized by elemental analysis, IR spectroscopy, thermogravimetry and magnetic measurements. Magnetic characterization revealed typical behavior of one-dimensional (1D ferrimagnetic chain as shown in the curves of temperature (T dependence of magnetic susceptibility (χM, in the form of χMT versus T, and dependence of magnetization (M with applied field (H.

  16. The reproducibility of random amplified polymorphic DNA (RAPD ...

    African Journals Online (AJOL)

    RAPD) profiles of Streptococcus thermophilus strains by using the polymerase chain reaction (PCR). Several factors can cause the amplification of false and non reproducible bands in the RAPD profiles. We tested three primers, OPI-02 MOD, ...

  17. The Plasmodium falciparum Sexual Development Transcriptome: A Microarray Analysis using Ontology-Based Pattern Identification

    National Research Council Canada - National Science Library

    Young, Jason A; Fivelman, Quinton L; Blair, Peter L; de la Vega, Patricia; Le Roch, Karine G; Zhou, Yingyao; Carucci, Daniel J; Baker, David A; Winzeler, Elizabeth A

    2005-01-01

    ... a full-genome high-density oligonucleotide microarray. The interpretation of this transcriptional data was aided by applying a novel knowledge-based data-mining algorithm termed ontology-based pattern identification (OPI...

  18. Implementacija aplikacije Smart Watch Workout za naprave iOS s pametno uro Apple Watch

    OpenAIRE

    Skledar, Dejan

    2016-01-01

    V diplomskem delu opišemo in predstavimo naprave ter operacijske sisteme, na katerih teče naša aplikacija. Le-ta je namenjena mobilnim navdušencem, ki jim pomaga do vsakodnevne aktivnosti. Prav tako opišemo potek, razvoj in cilje končnega izdelka na napravi iPhone kot tudi na napravi Apple Watch. Podatki, ki so pomembni za pravilno delovanje aplikacij, se shranjujejo v lokalno podatkovno bazo.

  19. Architecture and Functionality of the Advanced Life Support On-Line Project Information System

    Science.gov (United States)

    Hogan, John A.; Levri, Julie A.; Morrow, Rich; Cavazzoni, Jim; Rodriguez, Luis F.; Riano, Rebecca; Whitaker, Dawn R.

    2004-01-01

    An ongoing effort is underway at NASA Ames Research Center (ARC) to develop an On-line Project Information System (OPIS) for the Advanced Life Support (ALS) Program. The objective of this three-year project is to develop, test, revise and deploy OPIS to enhance the quality of decision-making metrics and attainment of Program goals through improved knowledge sharing. OPIS will centrally locate detailed project information solicited from investigators on an annual basis and make it readily accessible by the ALS Community via a Web-accessible interface. The data will be stored in an object-oriented relational database (created in MySQL) located on a secure server at NASA ARC. OPE will simultaneously serve several functions, including being an research and technology development (R&TD) status information hub that can potentially serve as the primary annual reporting mechanism for ALS-funded projects. Using OPIS, ALS managers and element leads will be able to carry out informed R&TD investment decisions, and allow analysts to perform accurate systems evaluations. Additionally, the range and specificity of information solicited will serve to educate technology developers of programmatic needs. OPIS will collect comprehensive information from all ALS projects as well as highly detailed information specific to technology development in each ALS area (Waste, Water, Air, Biomass, Food, Thermal, Controls and Systems Analysis). Because the scope of needed information can vary dramatically between areas, element-specific technology information is being compiled with the aid of multiple specialized working groups. This paper presents the current development status in terms of the architecture and functionality of OPIS. Possible implementation approaches for OPIS are also discussed.

  20. Cone beam computed tomography: An accurate imaging technique in comparison with orthogonal portal imaging in intensity-modulated radiotherapy for prostate cancer

    Directory of Open Access Journals (Sweden)

    Om Prakash Gurjar

    2016-03-01

    Full Text Available Purpose: Various factors cause geometric uncertainties during prostate radiotherapy, including interfractional and intrafractional patient motions, organ motion, and daily setup errors. This may lead to increased normal tissue complications when a high dose to the prostate is administered. More-accurate treatment delivery is possible with daily imaging and localization of the prostate. This study aims to measure the shift of the prostate by using kilovoltage (kV cone beam computed tomography (CBCT after position verification by kV orthogonal portal imaging (OPI.Methods: Position verification in 10 patients with prostate cancer was performed by using OPI followed by CBCT before treatment delivery in 25 sessions per patient. In each session, OPI was performed by using an on-board imaging (OBI system and pelvic bone-to-pelvic bone matching was performed. After applying the noted shift by using OPI, CBCT was performed by using the OBI system and prostate-to-prostate matching was performed. The isocenter shifts along all three translational directions in both techniques were combined into a three-dimensional (3-D iso-displacement vector (IDV.Results: The mean (SD IDV (in centimeters calculated during the 250 imaging sessions was 0.931 (0.598, median 0.825 for OPI and 0.515 (336, median 0.43 for CBCT, p-value was less than 0.0001 which shows extremely statistical significant difference.Conclusion: Even after bone-to-bone matching by using OPI, a significant shift in prostate was observed on CBCT. This study concludes that imaging with CBCT provides a more accurate prostate localization than the OPI technique. Hence, CBCT should be chosen as the preferred imaging technique.

  1. Plant operator selection system for evaluating employment candidates' potential for success in electric power plant operations positions

    International Nuclear Information System (INIS)

    Dunnette, M.D.

    1982-01-01

    The Plant Operator Selection System is a battery of tests and questionnaires that can be administered to job candidates in less than three hours. Various components of the battery measure what a job candidate has accomplished in previous educational and work situations, how well a candidate compares with others on a number of important aptitudes or abilities, and whether or not a candidate possesses the kind of personal stability required in power plant operations positions. A job candidate's answers to the tests and questionnaires of the Plant Operator Selection System are scored and converted to an OVERALL POTENTIAL INDEX. Values of the OVERALL POTENTIAL INDEX [OPI] range between 0 and 15. Candidates with high OPI values are much more likely to become effective and successful plant operators than candidates with low OPI values. It is possible to estimate the financial advantages to a company of using the Plant Operator Selection System in evaluating candidates for plant operations jobs

  2. Two- and three-dimensional lanthanide-organic frameworks constructed using 1-hydro-6-oxopyridine-3-carboxylate and oxalate ligands.

    Science.gov (United States)

    Liu, Cai-Ming; Xiong, Ming; Zhang, De-Qing; Du, Miao; Zhu, Dao-Ben

    2009-08-07

    6-Hydroxypyridine-3-carboxylic acid (6-HOPy-3-CO(2)H) reacts with Ln(2)O(3) (Ln = Nd, Sm, Eu, Gd) and oxalic acid (H(2)OX) under hydrothermal conditions to generate four novel lanthanide-organic coordination polymeric networks [Ln(2)(1H-6-Opy-3-CO(2))(2)(OX)(2)(H(2)O)(3)] x 2.5 H(2)O (Ln = Nd, 1; Sm, 2; 1H-6-Opy-3-CO(2)(-) = 1-hydro-6-oxopyridine-3-carboxylate) and [Ln(1H-6-Opy-3-CO(2))(OX)(H(2)O)(2)] x H(2)O (Ln = Eu, 3; Gd, 4). The new co-ligand 1H-6-Opy-3-CO(2)(-) anion was generated by the autoisomerization of the single deprotonated 6-HOPy-3-CO(2)(-) anion (from the enol form into the ketone one). 1 and 2 are isomorphous, they possess a three-dimensional architecture constructed from Ln(3+) ions bridged by oxalate anions and two types of 1H-6-Opy-3-CO(2)(-) bridges, showing a three-nodal (4,5)-connected topology (3.4(2).5(2).6(3).7.8)(2)(3.5(3).6(2))(2)(3(2).6.7(2).8) or a simplified uninodal 6-connected topology (3(3).4(6).5(5).6), both topologies are completely new; while only one type of 1H-6-Opy-3-CO(2)(-) bridge is used to construct the two-dimensional layer networks of 3 and 4 besides oxalate bridges, both complexes 3 and 4 are isostructural, exhibiting the honeycomb topology 6(3). The lanthanide contraction effect is believed to play a key role in directing the formation of a particular structure. A magnetic study of 1-3 indicated that the coupling interaction between Ln(3+) ions is weak.

  3. Demostración por inmunocitoquímica del pentapéptido metionina-encefalina en el tálamo e hipotálamo del gato

    OpenAIRE

    Torres Aragón, Yolanda

    1986-01-01

    La “historia” de las sustancias opiáceas se ha complicado extraordinariamente desde las primeras publicaciones, aparecidas a mediados de los setenta, que versaban sobre su localización en el cerebro y fluido cerebroespinal (Hughas, 1975; Terenius y Wahlstrom, 1975), y al descubrirse que ciertas neuronas presentaban receptores capaces de unirse a los opiáceos.El descubrimiento y caracterización de las encefalinas estimuló a que se realizaran numerosos estudios sobre su distribución en el siste...

  4. Development Approach of the Advanced Life Support On-line Project Information System

    Science.gov (United States)

    Levri, Julie A.; Hogan, John A.; Morrow, Rich; Ho, Michael C.; Kaehms, Bob; Cavazzoni, Jim; Brodbeck, Christina A.; Whitaker, Dawn R.

    2005-01-01

    The Advanced Life Support (ALS) Program has recently accelerated an effort to develop an On-line Project Information System (OPIS) for research project and technology development data centralization and sharing. There has been significant advancement in the On-line Project Information System (OPIS) over the past year (Hogan et al, 2004). This paper presents the resultant OPIS development approach. OPIS is being built as an application framework consisting of an uderlying Linux/Apache/MySQL/PHP (LAMP) stack, and supporting class libraries that provides database abstraction and automatic code generation, simplifying the ongoing development and maintenance process. Such a development approach allows for quick adaptation to serve multiple Programs, although initial deployment is for an ALS module. OPIS core functionality will involve a Web-based annual solicitation of project and technology data directly from ALS Principal Investigators (PIs) through customized data collection forms. Data provided by PIs will be reviewed by a Technical Task Monitor (TTM) before posting the information to OPIS for ALS Community viewing via the Web. Such Annual Reports will be permanent, citable references within OPIS. OPlS core functionality will also include Project Home Sites, which will allow PIS to provide updated technology information to the Community in between Annual Report updates. All data will be stored in an object-oriented relational database, created in MySQL(Reistered Trademark) and located on a secure server at NASA Ames Research Center (ARC). Upon launch, OPlS can be utilized by Managers to identify research and technology development (R&TD) gaps and to assess task performance. Analysts can employ OPlS to obtain the current, comprehensive, accurate information about advanced technologies that is required to perform trade studies of various life support system options. ALS researchers and technology developers can use OPlS to achieve an improved understanding of the NASA

  5. Optimality Measures for Monotone Equivariant Cluster Techniques.

    Science.gov (United States)

    1980-09-01

    complete linkage, u-clustering (u - .3, .5, .7), uv-clustering (uv = (.2,.4), (.2,.6), (.4,.6)) as well as the UPGMA algorithm. The idea will be to...Table 15. Notice that these measure-- do indeed pioduce difftxent verdicts. OPI rates UPGMA as best with uv = (.2,.4) R € second. By OP2, UPGMA is best...By OPI, UPGQA and uv = (.4,.6) are tied for first place, while by OP2, UPGMA is best with uv = (.2,.6), uv = (.2,.4) and uv = (.4,.6) close behind

  6. Decision Support Systems for Research and Management in Advanced Life Support

    Science.gov (United States)

    Rodriquez, Luis F.

    2004-01-01

    Decision support systems have been implemented in many applications including strategic planning for battlefield scenarios, corporate decision making for business planning, production planning and control systems, and recommendation generators like those on Amazon.com(Registered TradeMark). Such tools are reviewed for developing a similar tool for NASA's ALS Program. DSS are considered concurrently with the development of the OPIS system, a database designed for chronicling of research and development in ALS. By utilizing the OPIS database, it is anticipated that decision support can be provided to increase the quality of decisions by ALS managers and researchers.

  7. Charge Transport in 4 nm Molecular Wires with Interrupted Conjugation: Combined Experimental and Computational Evidence for Thermally Assisted Polaron Tunneling.

    Science.gov (United States)

    Taherinia, Davood; Smith, Christopher E; Ghosh, Soumen; Odoh, Samuel O; Balhorn, Luke; Gagliardi, Laura; Cramer, Christopher J; Frisbie, C Daniel

    2016-04-26

    We report the synthesis, transport measurements, and electronic structure of conjugation-broken oligophenyleneimine (CB-OPI 6) molecular wires with lengths of ∼4 nm. The wires were grown from Au surfaces using stepwise aryl imine condensation reactions between 1,4-diaminobenzene and terephthalaldehyde (1,4-benzenedicarbaldehyde). Saturated spacers (conjugation breakers) were introduced into the molecular backbone by replacing the aromatic diamine with trans-1,4-diaminocyclohexane at specific steps during the growth processes. FT-IR and ellipsometry were used to follow the imination reactions on Au surfaces. Surface coverages (∼4 molecules/nm(2)) and electronic structures of the wires were determined by cyclic voltammetry and UV-vis spectroscopy, respectively. The current-voltage (I-V) characteristics of the wires were acquired using conducting probe atomic force microscopy (CP-AFM) in which an Au-coated AFM probe was brought into contact with the wires to form metal-molecule-metal junctions with contact areas of ∼50 nm(2). The low bias resistance increased with the number of saturated spacers, but was not sensitive to the position of the spacer within the wire. Temperature dependent measurements of resistance were consistent with a localized charge (polaron) hopping mechanism in all of the wires. Activation energies were in the range of 0.18-0.26 eV (4.2-6.0 kcal/mol) with the highest belonging to the fully conjugated OPI 6 wire and the lowest to the CB3,5-OPI 6 wire (the wire with two saturated spacers). For the two other wires with a single conjugation breaker, CB3-OPI 6 and CB5-OPI 6, activation energies of 0.20 eV (4.6 kcal/mol) and 0.21 eV (4.8 kcal/mol) were found, respectively. Computational studies using density functional theory confirmed the polaronic nature of charge carriers but predicted that the semiclassical activation energy of hopping should be higher for CB-OPI molecular wires than for the OPI 6 wire. To reconcile the experimental and

  8. Asesinatos empleando relajantes musculares, opioides y otras drogas anestésicas

    OpenAIRE

    Martínez Hurtado, Eugenio; Gómez García, Ana María

    2012-01-01

    Los anestésicos, los opiáceos y los relajantes musculares pueden deprimir la respiración y otros procesos vitales hasta el extremo de producir la muerte si no se mantiene la ventilación. De modo que estos fármacos se han empleado para la eutanasia, el suicidio y las ejecuciones. Los criminales también han reparado en las posibilidades letales de los anestésicos, y durante los años recientes se han cometido homicidios empleando hipnóticos, anestésicos generales inhalados, opiáceos y relajantes...

  9. Dynamic risk assessment method – a proposal for assessing risk in water supply system / Metoda dynamicznego szacowania ryzyka – propozycja oceny ryzyka w systemie zaopatrzenia wody

    Directory of Open Access Journals (Sweden)

    Fortmann-Roe Scott

    2015-06-01

    Full Text Available Dynamika Systemów jest metodologią modelowania i analizy złożonych systemów. Taki złożony system może być charakteryzowany przez wzajemne proste połączenia elementów oraz istniejące sprzężenia zwrotne. Przeprowadzenie oceny ryzyka przy modelowaniu Systemów Dynamicznych jest trudnym wyzwaniem. Chociaż w niektórych przypadkach, uzyskane za pomocą symulacji serie wyników mogą się wydawać przypadkowe, to jednak często istnieje wysoki stopień autokorelacji między tymi seriami wynikający z istnienia powiązań zwrotnych w systemie. Artykuł przedstawia propozycje Metody Dynamicznego Szacowania Ryzyka (MDSR, która pozwala oceniać ryzyko związane z hipotetycznymi kosztami zachorowań wywołanymi skażeniem systemu zaopatrzenia w wodę przez Cryptosporidium.

  10. Understanding the Mechanism of Soil Erosion from Outdoor Model ...

    African Journals Online (AJOL)

    A method for obtaining important data on eroded soils, using a one eight experimental slope model is presented. The scope of the investigation herein described encompassed three locations in the south- eastern parts of Nigeria, which are belts of severe erosion, namely Opi-Nsukka, Agulu and Udi, [Fig. 1.] Soil samples ...

  11. DMPD: MDA5/RIG-I and virus recognition. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18272355 MDA5/RIG-I and virus recognition. Takeuchi O, Akira S. Curr Opin Immunol. ...2008 Feb;20(1):17-22. Epub 2008 Feb 12. (.png) (.svg) (.html) (.csml) Show MDA5/RIG-I and virus recognition.... PubmedID 18272355 Title MDA5/RIG-I and virus recognition. Authors Takeuchi O, Akira S. Publication Curr Opi

  12. Hypertension 1996 simplified guidelines for primary care nurses and ...

    African Journals Online (AJOL)

    into 90 - 100 or 100 - 115 mmHg ranges, depending on the risk factor situation. Those at high risk get treated as if in the higher BP category. MRC/UCT Ischaemic Heart Disease Research Unit and Hypertension. Clinic, Department of Medicine, University of Cape Town. L H. Opie. M.D.. PH.D.. ERC.? SAMJ Volume 86 No.

  13. Podejście oparte na ryzyku w świetle wymagań normy PN-EN ISO 9001:2015-10.

    Directory of Open Access Journals (Sweden)

    Romana Zając

    2017-09-01

    Full Text Available W artykule poruszono zagadnienie zarządzania ryzykiem w odniesieniu do organizacji wdrażających system zarządzania jakością zgodny ISO 9001:2015. Opisano proces analizy ryzyka oraz przedstawiono przykładowy opis metodyki oceny ryzyka.

  14. Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast

    International Nuclear Information System (INIS)

    Barajas, Daniel; Xu, Kai; Sharma, Monika; Wu, Cheng-Yu; Nagy, Peter D.

    2014-01-01

    Positive-stranded RNA viruses induce new membranous structures and promote membrane proliferation in infected cells to facilitate viral replication. In this paper, the authors show that a plant-infecting tombusvirus upregulates transcription of phospholipid biosynthesis genes, such as INO1, OPI3 and CHO1, and increases phospholipid levels in yeast model host. This is accomplished by the viral p33 replication protein, which interacts with Opi1p FFAT domain protein and Scs2p VAP protein. Opi1p and Scs2p are phospholipid sensor proteins and they repress the expression of phospholipid genes. Accordingly, deletion of OPI1 transcription repressor in yeast has a stimulatory effect on TBSV RNA accumulation and enhanced tombusvirus replicase activity in an in vitro assay. Altogether, the presented data convincingly demonstrate that de novo lipid biosynthesis is required for optimal TBSV replication. Overall, this work reveals that a (+)RNA virus reprograms the phospholipid biosynthesis pathway in a unique way to facilitate its replication in yeast cells. - Highlights: • Tombusvirus p33 replication protein interacts with FFAT-domain host protein. • Tombusvirus replication leads to upregulation of phospholipids. • Tombusvirus replication depends on de novo lipid synthesis. • Deletion of FFAT-domain host protein enhances TBSV replication. • TBSV rewires host phospholipid synthesis

  15. West Indian Sojourners in Guatemala and Honduras

    Directory of Open Access Journals (Sweden)

    Ronald N. Harpelle

    2012-12-01

    Full Text Available Review of: Race, Nation, and West Indian Immigration to Honduras, 1890-1940. Glenn A. Chambers. Baton Rouge: Louisiana State University Press, 2010. xii +202 pp. (Cloth US$ 35.00Black Labor Migration in Caribbean Guatemala, 1882-1923. Frederick Douglass Opie. Gainesville: University Press of Florida, 2009. 145 pp. (Cloth US$ 65.00

  16. Regulations for the maintenance division of the RA reactor, Annex 6; Prilog 6 - Pravilnik poslovanja Odelenja odrzavanja i remonta reaktora RA

    Energy Technology Data Exchange (ETDEWEB)

    Badrljica, R [Reaktor RA, Odelenje odrzavanja, Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1965-12-15

    The regulations for the Division of reactor maintenance include the organizational scheme, tasks of the Division, and operation procedures for all the staff members. [Serbo-Croat] Pravilnik o radu Odelenja za odrzavanje reaktora RA sadrzi opis organizacione strukture sluzbe, zadataka Odelenja, organizacije rada, nacin poslovanja za sve saradnike Odelenja.

  17. JPRS Report, Reference Aid: Glossary of Acronyms and Abbreviations of Spain

    Science.gov (United States)

    1988-12-01

    Information Center CETME Centro de Estudios Teenicos de Materiales Especiales Special Equipment Research and Testing Center CF capitän de fragata...Organization OLLA Organizacio de Lluita Armada ON Orden Nuevo Armed Struggle Organization New Order OPI Oposiciön de Izguierda Leftist

  18. 13. I kuulutas ETV kultuurisaade "OP!" välja oma lemmikud...

    Index Scriptorium Estoniae

    2004-01-01

    Tegijad koos 30 kultuuritegija ja -ajakirjanikuga valisid 2003. a. "OP!-is" kajastatu hulgast oma lemmikud: näitus - Tõnu Arraku damaskuse terasest noad ajaloomuuseumis, maja - restaureeritud Albu mõisakool (arhitekt Jaan Jõgi, sisearhitekt Nele Rohtla). Auhinnaks kunstnik Ave Nahkuri maalitud pilt

  19. The diets of littoral fish from the Cape Peninsula

    African Journals Online (AJOL)

    mainly by poisoning with rotenone dissolved in acetone, but hand nets and baited hooks were also used on occasion. All fish were killed by placing in formalin or alcohol, after which they were ...... A wide variety of prey species were taken (Table 3), with ..... first weeks after the beginning of exogenous feeding in Lake Opi-.

  20. 7 CFR Exhibit A to Subpart G of... - Departmental Regulation

    Science.gov (United States)

    2010-01-01

    ... Policy. Date: March 22, 1983. OPI: Land Use Staff, Soil Conservation Service. Section 1. Purpose 2... export markets. Continued conversion of the Nation's wetlands may reduce the availability of adequate... resources in such manner as to facilitate restoration. This restoration would reestablish or enhance food...

  1. Prostate Cancer Detected by Screening in a Semi Urban Community ...

    African Journals Online (AJOL)

    Towns that share a common border with Nsukka are Edem Ani, Alor‑uno, Opi, Orba, and Ede‑Oballa. Nsukka LGA has an area of 1810 km² and a population of 309,633 at the 2006 census. All consecutive responders who met the inclusion criteria were recruited. Subjects and Methods: A screening outreach was conducted ...

  2. Food preservation and security at household level in rural Nsukka ...

    African Journals Online (AJOL)

    In Nigeria, food insecurity at the household level can partly be attributed to poor preservation of post-harvest surpluses. This study sought to demonstrate a relationship (if any) between preservation of post harvest surpluses and food security at rural household level. Eha-Alumona and Opi-Uno, in Nsukka, Enugu State were ...

  3. GenBank blastx search result: AK104002 [KOME

    Lifescience Database Archive (English)

    Full Text Available opy of the insertion element IS2 is inserted after cloning in E.coli by duplicating a 5 base pair sequence. This is the wildtype TRP5 gene before insertion of IS2.|PLN PLN 6e-22 +1 ...

  4. Synthesis, characterization and study of the magnetic properties of a coordination polymer containing cobalt(II) and copper(II); Sintese, caracterizacao e estudo das propriedades magneticas de um polimero de coordenacao contendo cobalto(II) e cobre(II)

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Tamyris T. da; Stumpf, Humberto O.; Pereira, Cynthia L.M., E-mail: cynthialopes@ufmg.br [Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil); Pires, Heber S.; Oliveira, Luiz F.C. de [Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Juiz de Fora, MG (Brazil); Pedroso, Emerson F. [Departamento de Quimica, Centro Federal de Educacao Tecnologica de Minas Gerais, Belo Horizonte, MG (Brazil); Nunes, Wallace C. [Instituto de Fisica, Universidade Federal Fluminense, Niteroi, RJ (Brazil)

    2012-07-01

    This work describes the synthesis and characterization of two new compounds with ligand opy (N-(2-pyridyl)oxamate): the copper(II) precursor [Me{sub 4}N]{sub 2}[Cu(opy){sub 2}].5H{sub 2}O and Co{sup II} Cu{sup II} coordination polymer {l_brace}[Co Cu(opy){sub 2}]{r_brace}{sub n}x4nH{sub 2}O. This latter compound was obtained by reaction of [Me{sub 4}N]{sub 2}[Cu(opy){sub 2}].5H{sub 2}O and CoCl{sub 2}.6H{sub 2}O in water. The heterobimetallic Co{sup II} Cu{sup II} chain was characterized by elemental analysis, IR spectroscopy, thermogravimetry and magnetic measurements. Magnetic characterization revealed typical behavior of one-dimensional (1D) ferrimagnetic chain as shown in the curves of temperature (T) dependence of magnetic susceptibility ({chi}{sub M}), in the form of {chi}{sub M}T versus T, and dependence of magnetization (M) with applied field (H). (author)

  5. Podejście oparte na ryzyku w świetle wymagań normy PN-EN ISO 9001:2015-10.

    OpenAIRE

    Romana Zając

    2017-01-01

    W artykule poruszono zagadnienie zarządzania ryzykiem w odniesieniu do organizacji wdrażających system zarządzania jakością zgodny ISO 9001:2015. Opisano proces analizy ryzyka oraz przedstawiono przykładowy opis metodyki oceny ryzyka.

  6. The Chameleon Concept: Modeling Quaternary Geomorphic Surfaces Using Laboratory, Field, and Imaging Spectrometry in the Lower Colorado Sonoran Desert

    Science.gov (United States)

    2005-11-01

    Oblique aerial photographs of dry deciduous tropical forest at the STRI Tropical Research Crane at the Parque Natural Metropolitano, Republic of Panama...Research Crane at the Parque Natural Metropolitano, Republic of Panama. ......................... 134 58. Original (a) and synthetic (b and c) tropical... Parque Natural Metropolitano, Republic of Panama. 133 b. Double canopy tropical forest diversity as seen from the can- opy crane gondola

  7. Characterization of specific random amplified polymorphic (RAPD ...

    African Journals Online (AJOL)

    toshiba

    2013-04-10

    Apr 10, 2013 ... GGG CCA CTG T. 8. 8. 0. 97. OPY-20. AGC CGT GGA A. 7. 7. 0. 98. OPZ-13. GAC TAA GCC C. 0. 0. 0 fingerprinting differentiation was combined with bulked segregant analysis (Michelmore, et al. 1991). A total of. 98 operon RAPD primers (Almaeda, USA) were used in the first step differential screening in ...

  8. Detection of physiological changes after exercise via a remote optophysiological imaging system

    Science.gov (United States)

    Sun, Yu; Hu, Sijung; Azorin-Peris, Vicente; Zheng, Jia; Greenwald, Stephen; Chambers, Jonathon; Zhu, Yisheng

    2011-03-01

    A study of blood perfusion mapping was performed with a remote opto-physiological imaging (OPI) system coupling a sensitive CMOS camera and a custom-built resonant cavity light emitting diode (RCLED) ringlight. The setup is suitable for the remote assessment of blood perfusion in tissue over a wide range of anatomical locations. The purpose of this study is to evaluate the reliability and stability of the OPI system when measuring a cardiovascular variable of clinical interest, in this case, heart rate. To this end, the non-contact and contact photoplethysmographic (PPG) signals obtained from the OPI system and conventional PPG sensor were recorded simultaneously from each of 12 subjects before and after 5-min of cycling exercise. The time-frequency representation (TFR) method was used to visualize the time-dependent behavior of the signal frequency. The physiological parameters derived from the images captured by the OPI system exhibit comparable functional characteristics to those taken from conventional contact PPG pulse waveform measurements in both the time and frequency domains. Finally and more importantly, a previously developed opto-physiological model was employed to provide a 3-D representation of blood perfusion in human tissue which could provide a new insight into clinical assessment and diagnosis of circulatory pathology in various tissue segments.

  9. A Study of Programs and Services: An Action Report. Montana State Dissemination Worksessions, Office of Public Instruction (Helena, Montana, November and December 1979 and January 1980).

    Science.gov (United States)

    Northwest Regional Educational Lab., Portland, OR.

    Input into the design, content, and development of a comprehensive resource tool--the Montana Educational Resources and Services notebook--was provided by the 16 members of a planning team made up of Office of Public Instruction (OPI) managers and consultants, selected Montana educators, and Northwest Regional Educational Laboratory Dissemination…

  10. Another Look at Correlations between the Oral Proficiency Interview and the Zertifikat Deutsch als Fremdsprache.

    Science.gov (United States)

    Vazulik, Johannes; Brown, Cheri

    A study supplementing earlier research by Lalande and Schweckendiek investigated comparisons and correlations obtained from testing a group of 17 university students of German using both the American Council on the Teaching of Foreign Languages (ACTFL) Oral Proficiency Interview (OPI) and the most recent revision of the examination for the…

  11. Spectro radiometry Applied to Soil Science

    International Nuclear Information System (INIS)

    Schmid, T.; Chabrillat, S.; Guerrero, C.; Jimenez, M.; Lopez, F.; Palacios, A.; Pelayo, M.; Rodriguez, M.

    2012-01-01

    This work is the result of an internal course that was held in CIEMAT under the framework of activities within the Itinerario Formativo: Tecnicas experimentales de apoyo a la Investigacion I+D+I, as part of the Programa de Acciones Conjuntas de OPIs (CIEMAT, INTA and IGME) financed by the Instituto Nacional de Administracion Publica (INAP). The course was aimed at researchers, technical staff and students associated to the different OPIs introducing them to spectroradiometric techniques for determining soil properties and processes and obtain a thorough insight into the compilation and applications of spectral libraries. This course was directed and organized by CIEMAT with experts specialized in the field of spectro radiometry presenting the corresponding theory and application as well as practical work carried out in the laboratory and in the field. The course is within the research lines carried out by the group Unidad de Conservacion y Recuperacion de Suelos of the Departamento de Medio Ambiente in CIEMAT. (Author)

  12. Commercial Property Index Construction Methodology: A Review on Literature and Practice

    Directory of Open Access Journals (Sweden)

    Md Nasir Daud

    2014-12-01

    Full Text Available This paper reviews the literature on commercial property index construction methodology. Alongside this, index construction methodology employed by various organizations in producing existing commercial property indices is also discussed. The aim of the review is to identify the best possible methodology option to adopt in developing Kuala Lumpur Office Price Index (KL - OPI. Among the Asean countries, Singapore is the only country in this region that produces retail and office price index. In the case of Malaysia, this is the first study of this nature in the country, which outcome would be useful indicator for the industry. Having reviewed the existing methodologies of commercial property indices, it is best to model KL-OPI by adopting the hedonic price method

  13. Spectro radiometry Applied to Soil Science; Espectrorradiometria Aplicada a la Ciencia del Suelo

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, T; Chabrillat, S; Guerrero, C; Jimenez, M; Lopez, F; Palacios, A; Pelayo, M; Rodriguez, M

    2012-07-01

    This work is the result of an internal course that was held in CIEMAT under the framework of activities within the ''Itinerario Formativo: Tecnicas experimentales de apoyo a la Investigacion I+D+I'', as part of the Programa de Acciones Conjuntas de OPIs (CIEMAT, INTA and IGME) financed by the Instituto Nacional de Administracion Publica (INAP). The course was aimed at researchers, technical staff and students associated to the different OPIs introducing them to spectroradiometric techniques for determining soil properties and processes and obtain a thorough insight into the compilation and applications of spectral libraries. This course was directed and organized by CIEMAT with experts specialized in the field of spectro radiometry presenting the corresponding theory and application as well as practical work carried out in the laboratory and in the field. The course is within the research lines carried out by the group Unidad de Conservacion y Recuperacion de Suelos of the Departamento de Medio Ambiente in CIEMAT. (Author)

  14. An interactive health communication application for supporting parents managing childhood long-term conditions: outcomes of a randomized controlled feasibility trial.

    Science.gov (United States)

    Swallow, Veronica M; Knafl, Kathleen; Santacroce, Sheila; Campbell, Malcolm; Hall, Andrew G; Smith, Trish; Carolan, Ian

    2014-12-03

    Families living with chronic or long-term conditions such as chronic kidney disease (CKD), stages 3-5, face multiple challenges and respond to these challenges in various ways. Some families adapt well while others struggle, and family response to a condition is closely related to outcome. With families and professionals, we developed a novel condition-specific interactive health communication app to improve parents' management ability-the online parent information and support (OPIS) program. OPIS consists of a comprehensive mix of clinical caregiving and psychosocial information and support. The purpose of this study was to (1) assess feasibility of a future full-scale randomized controlled trial (RCT) of OPIS in terms of recruitment and retention, data collection procedures, and psychometric performance of the study measures in the target population, and (2) investigate trends in change in outcome measures in a small-scale RCT in parents of children with CKD stages 3-5. Parents were recruited from a pediatric nephrology clinic and randomly assigned to one of two treatment groups: usual support for home-based clinical caregiving (control) or usual support plus password-protected access to OPIS for 20 weeks (intervention). Both groups completed study measures at study entry and exit. We assessed feasibility descriptively in terms of recruitment and retention rates overall; assessed recruitment, retention, and uptake of the intervention between groups; and compared family condition management, empowerment to deliver care, and fathers' involvement between groups. We recruited 55 parents of 39 children (42% of eligible families). Of those, about three-quarters of intervention group parents (19/26, 73%) and control group parents (22/29, 76%) were retained through completion of 20-week data collection. The overall retention rate was 41/55 (75%). The 41 parents completing the trial were asked to respond to the same 10 questionnaire scales at both baseline and 20 weeks

  15. STOCK MARKET WEALTH-EFFECTS DURING PRIVATIZATION INITIAL PUBLIC OFFERS IN CHILE (1984-1989

    Directory of Open Access Journals (Sweden)

    ROBERTO J. SANTILLÁN SALGADO

    2010-01-01

    económicas y políticas prevalecientes. En particular, se presentan los detalles operativos del mecanismo de emisión de acciones, complementado con un estudio estadístico de los Rendimientos Ajustados por el Mercado de las OPIs. Aunque el tamaño de la muestra es limitado y no permite alcanzar una validez externa, el análisis confirma la presencia de patrones de desempeño muy similares a los observados en OPIs tanto privadas como privatizadoras, de acuerdo con otros estudios relacionados (Aggarwal, Leal y Hernández, 1993; Dewenter y Malatesta, 1997; Loughran, Ritter y Rydqvist, 1994; Perotti y Guney, 1993.

  16. EPICS Input/Output Controller (IOC) application developer's guide. APS Release 3.12

    International Nuclear Information System (INIS)

    Kraimer, M.R.

    1994-11-01

    This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers

  17. An update on periodontic-orthodontic interrelationships

    OpenAIRE

    Dannan, Aous

    2010-01-01

    Talking about periodontic-orthodontic interrelationships is related primarily to the 1960s, where a generalized increase in salivary bacterial counts, especially Lactobacillus, had been shown after orthodontic band placement. The purpose of this article is to provide the dental practitioner with basic understanding of the interrelationship between periodontics and orthodontics by means of representing classical studies, and, to give an update on this topic by demonstrating the most recent opi...

  18. Načrtovanje in montaža protivlomnega alarmnega sistema

    OpenAIRE

    ŠTULAR, ALEŠ

    2016-01-01

    Diplomsko delo obravnava vrste alarmnih sistemov za tehnično varovanje. V nadaljevanju se posvetimo osnovnim gradnikom protivlomnega alarmnega sistema. Našteti so elementi alarmnega sistema in opis njihovega delovanja. Posebno pozornost posvetimo prenosu alarmnih sporočil na varnostno nadzorni center. Zaradi velikih razlik v ceni ter zanesljivosti samih prenosnih poti, je potrebna velika pozornost pri izbiri prave. Naštete so najpogostejše prenosne poti in njihove glavne značilnosti. Na koncu...

  19. Annual report of the group for maintenance of electrical equipment; Godisnji izvestaj elektro grupe

    Energy Technology Data Exchange (ETDEWEB)

    Rajic, M [Odelenje odrzavanja, Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1965-12-15

    This report includes detailed description of repairs and revisions of the electrical equipment of the RA reactor which were done according to the annual plan during the periods when reactor was not operated. Unplanned repairs are part of this report as well. [Serbo-Croat] Ovaj izvestaj sadrzi detaljan opis remontnih i revizionih radova na elektroopremi reaktora RA izvrsenih prema godisnjem planu u periodima kada reaktor nije radio. Vanplanski poslovi ukljucujuci popravke elektroopreme su takodje deo ovog izvestaja.

  20. Regulations and instructions for RA reactor operation; Propisi i uputstva za pogon reaktora 'A'

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-07-01

    This regulatory guide consists of following 4 chapters: Description of the RA reactor, organization scheme, regulations for performing experiments; Regulations for staff on duty; Instructions for operating the vacuum systems, heavy water and helium systems; and evacuation in case of accident. [Serbo-Croat] Ovaj pravilnik sadrzi sledeca 4 poglavlja: Opis reaktora RA, sema organizacije rada, propisi za izvodjenje eksperimenata; Pravilnik za rad dezurnog osoblja; Uputstva za rada sa vakuum sistemima, sistemom teske vode, sistemom helijuma; evakuacija u slucaju udesa.

  1. Radiation protection at the RA Reactor in 1985, Part -2, Annex 2c, Reconstruction of the measuring device on the meteorology tower; Deo 2 - Zastita od zracenja kod reaktora RA u 1985. godini - Prilog 2c - Rekonstrukcija merne instalacije na meteoroloskom stubu

    Energy Technology Data Exchange (ETDEWEB)

    Savic, Z; Stevanovic, M; Kovacevic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1985-12-01

    Original meteorology measuring instrumentation dates from 1960-1961. In order to enable more efficient measurements it was indispensable to reconstruct measuring devices completely. Description of the reconstruction works and specification is included in this report. [Serbo-Croat] Prvobitna instrumentacija namenjena meteoroloskim merenjima datira iz perioda 1960-1961. Sa ciljem da se merenja usavrse bilo je neophodno rekonstruisati celokupnu mernu opremu. Opis rekonstrukcije i specifikacija opreme sadrzani su u ovom izvestaju.

  2. A Shared Burden: The Military and Civilian Consequences of Army Pain Management Since 2001

    Science.gov (United States)

    2015-08-01

    are derived from the opi- um poppy.2 Opioids also include synthetic pharmaceuticals prescribed to manage pain, which operate on the central nervous...soldiers choosing to begin taking opioids from a lack of discipline. 3 While illegal recreational drugs such as marijuana or cocaine historically have been...Army soldiers during the Vietnam War used marijuana , and 45% tried narcotics (34% used heroin; 38% used opium.)41 The post-Vietnam Army was ill

  3. Bivariate Probit Models for Analysing how “Knowledge” Affects Innovation and Performance in Small and Medium Sized Firms

    OpenAIRE

    FARACE, Salvatore; MAZZOTTA, Fernanda

    2011-01-01

    This paper examines the determinants of innovation and its effects on small- and medium-sized firms We use the data from the OPIS databank, which provides a survey on a representative sample of firms from a province of the Southern Italy. We want to study whether small and medium sized firms can have a competitive advantage using their innovative capabilities, regardless of their sectoral and size limits. The main factor influencing the likelihood of innovation is knowledge, which is acquired...

  4. Phosphorylated Derivatives of Alkaloids and Nitrogen-containing Heterocycles — Cholinesterase Inhibitors

    Science.gov (United States)

    Sadykov, Abid S.; Dalimov, D. N.; Godovikov, Nikolai N.

    1983-10-01

    The review deals with the synthesis and anticholinesterase activities of phosphorylated derivatives of certain alkaloids and nitrogen-containing heterocycles. It is shown that the conformational properties of the alkaloid and nitrogen-containing heterocycle residues in the composition of the organophosphorus inhibitor (OPI) molecule play an important role in the inhibition of the catalytic activity of cholinesterases. The type of inhibition of cholinesterases also varies as a function of chemical structure. The bibliography includes 45 references.

  5. Airland Battle Doctrine

    Science.gov (United States)

    1988-09-01

    Professional Paper 463 / September 1988 OTIC - EL cOPY V 0- 00 00 N Airland Battle Doctrine DTIC S ELECTE DEC 2 81988D Douglas W. Skinner Dcb A...missiles to ground targets. Initial deployment will be on the Army’s OV-i Bronco and the Air Force’s TR-l and C-18. This is another outgrowth of the

  6. Zavedanje pomembnosti vertikalnega komuniciranja med nadrejenimi in podrejenimi v podjetju in vpliv na (ne) uspeh podjetja

    OpenAIRE

    Bezjak, Mojca

    2017-01-01

    Vertikalno komuniciranje je dvosmerno komuniciranje - povraten proces.Predstavimo vertikalno komuniciranje med nadrejenimi in podrejenimi v podjetju in vpliv na uspeh podjetja.Predstavitev različnih vrst komuniciranja, vplivov komuniciranja na človeka. Opišemo povezanost vertikalnega komuniciranja,medsebojnih odnosov in uspeh podjetja. V empiričnem delu diplomskega projekta z odgovori na vprašanja, ki se navezujejo na vertikalno komuniciranje in medsebojne odnose med nadrejenimi in podrejenim...

  7. APPLICA TION OF OPTICAL LOGIC GATES Avireni Srinivasulu, L ...

    African Journals Online (AJOL)

    Figure 1 shows the circuit diagram of optical NOT with light input OPi. The light dependent resistor. LDR is connected in series to UJT emitter and the power supply +1.8V to the base B2 through a pair ... LDR2 are connected in parallel to the UJT emitter terminal. Optical output OPo of NOR occurs only when both the inputs ...

  8. Coverage of Continuous Regions in Euclidean Space Using Homogeneous Resources with Application to the Allocation of the Phased Array Radar Systems

    Science.gov (United States)

    2011-06-01

    centered at OPi with radius β. Let δ ∗ be the coverage level of the entire polygon P , AP be the area of polygon P , APi be the area of sub-polygon...30 1104 512 1120 992 512 297 1.72 40 600 512 480 544 480 167 2.87 80 158 128 120 136 120 42 2.86 120 70 32 70 62 32 19 1.68 160 38 32 30 34 30 11

  9. Enantioselective preparation of 1,3-dithiane 1-oxides by asymmetric oxidation of 1,3-dithianes bearing a chiral auxiliary

    OpenAIRE

    Yoshihiko, Watanabe; Yojiro, Ono; Shigefumi, Hayashi; Yoshio, Ueno; Takeshi, Toru

    1996-01-01

    Oxidation of 1,3-dithianes bearing a chiral auxiliary derived from (+) or (-)-camphor or diacetone D-(+)-glucose by the Sharpless reagent [Ti(OPi)4-diethyl L-(+)- or D-(-)-tartrate-ButOOH] affords, with high stereoselectivity, the monosulfoxides in good to excellent yields. Removal of the chiral auxiliary by base-catalysed hydrolysis yields (R)- and (S)-1,3-dithiane 1-oxides in high yields.

  10. Core Operations of the Metals and Ceramics Information Center (A DoD information Analysis Center)

    Science.gov (United States)

    1990-08-30

    1214 Hy-Tuf Steel 12 Sep 4208 Wassaloy? 36 Dec 1215 Nitralloy 135 Mod 8 Dec 4310 Haynes Alloy 188 40 1987 Mar 1203 4140 Sterl 34 Mar 1601 A-286 Steel 37...BE /Ej*Az5 pofj.’t FRACT UjPE CATA FOR AISI 521 ,O ALLCY STEEL r-L’I1 AFS. 6 L Pesconm C OPY OF SELECTED DATA FAxED ,-T LCCP"EED 1MILES A AE OPol.es

  11. Operator interface programs for KSTAR operation

    International Nuclear Information System (INIS)

    Lee, Sangil; Park, Mikyung; Park, Jinseop; Na, Hoonkyun; Kwon, M.

    2013-01-01

    Beginning the first plasma discharging experiment of KSTAR since 2008, KSTAR performed the third plasma discharging experiment by 2010. During the experiment of three times, KSTAR OPerator Interface (OPI) programs have been developed for KSTAR operation by itself. OPI programs used in KSTAR were implemented by KSTAR widget plug-in Toolkit (KWT). The KWT means the plug-in library implemented by Qt-based user interface development software. The main purpose of developing the KWT library is to implement full automation libraries having interface with the automated EPICS channel access (CA) guaranteeing the flexibility for requirements of operators. In addition, it has advantages in minimizing human code error and maximizing utilization of the limited human resource. According to the increasing of control systems, a number of OPI servers connected to one EPICS gateway server caused the connection problem and increased the amount of the network data packets. To solve these problems, an algorithm of “CachedChannelAccess” for shared memory base was implemented into an inner logic of the KWT library. KSTAR control system monitoring (CSM) program is one of applications developed by using KWT library. The function of CSM program is to notify alarm to operators by checking health status of every server's network health status and resource (cpu, memory, network packets, disk usage rate and system/user defined process) usage state. Another application is a post-shot sequencing program which is activated after every shot is completed. This application is to display major plasma parameters and diagnostic data in chart form, to save this data to database, and to transfer a chart image file to a web server. This paper describes the technical details how to develop OPI applications which have high productivity using Qt on the EPICS-based control system

  12. Aircraft Alerting Systems Criteria Study. Volume 1. Collation and Analysis of Aircraft Alerting Systems Data

    Science.gov (United States)

    1977-05-01

    ott the.747-Vas opi the 7,37 beca’ws the � has foiiy paralkA.hydrauliu syst~et~s,’wfiereas %the 737 has only two patallel systems. is hefalue f wo...8217.. . -" "" - - - - - OLICTRICAL 2 2 13 2 10 1 EMERGENCY EQUIPMENT 1 1 1 1 - - , PIM PROTECTION 1 3 2 g 2 FLIGHT CONTROLS 2 2F,3 6 2 PLIGHT INITRUMINTATION a 2 a 4 1 1 1

  13. Perspektywa interesariuszy w ujeciu historycznym

    NARCIS (Netherlands)

    Neave, Guy

    2003-01-01

    Przedmiotem artykułu jest analiza zjawiska pojawienia się w systemach szkolnictwa wyższego „społeczeństwa interesariuszy” (ang. stakeholders society), a także opis różnych ujęć problemu oraz przyczyn powstawania tych różnic. Zdaniem autora w definicji pojęcia „interesariusz”.w odniesieniu do

  14. De l'importance des orbites periodiques: Detection et applications

    Science.gov (United States)

    Doyon, Bernard

    L'ensemble des Orbites Periodiques Instables (OPIs) d'un systeme chaotique est intimement relie a ses proprietes dynamiques. A partir de l'ensemble (en principe infini) d'OPIs cachees dans l'espace des phases, on peut obtenir des quantites dynamiques importantes telles les exposants de Lyapunov, la mesure invariante, l'entropie topologique et la dimension fractale. En chaos quantique (i.e. l'etude de systemes quantiques qui ont un equivalent chaotique dans la limite classique), ces memes OPIs permettent de faire le pont entre le comportement classique et quantique de systemes non-integrables. La localisation de ces cycles fondamentaux est un probleme complexe. Cette these aborde dans un premier temps le probleme de la detection des OPIs dans les systemes chaotiques. Une etude comparative de deux algorithmes recents est presentee. Nous approfondissons ces deux methodes afin de les utiliser sur differents systemes dont des flots continus dissipatifs et conservatifs. Une analyse du taux de convergence des algorithmes est aussi realisee afin de degager les forces et les limites de ces schemes numeriques. Les methodes de detection que nous utilisons reposent sur une transformation particuliere de la dynamique initiale. Cette astuce nous a inspire une methode alternative pour cibler et stabiliser une orbite periodique quelconque dans un systeme chaotique. Le ciblage est en general combine aux methodes de controle pour stabiliser rapidement un cycle donne. En general, il faut connaitre la position et la stabilite du cycle en question. La nouvelle methode de ciblage que nous presentons ne demande pas de connaitre a priori la position et la stabilite des orbites periodiques. Elle pourrait etre un outil complementaire aux methodes de ciblage et de controle actuelles.

  15. Operator interface programs for KSTAR operation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sangil, E-mail: leesi@nfri.re.kr; Park, Mikyung, E-mail: mkpark@nfri.re.kr; Park, Jinseop, E-mail: linupark@nfri.re.kr; Na, Hoonkyun, E-mail: hkna@nfri.re.kr; Kwon, M., E-mail: kwonm@nfri.re.kr

    2013-11-15

    Beginning the first plasma discharging experiment of KSTAR since 2008, KSTAR performed the third plasma discharging experiment by 2010. During the experiment of three times, KSTAR OPerator Interface (OPI) programs have been developed for KSTAR operation by itself. OPI programs used in KSTAR were implemented by KSTAR widget plug-in Toolkit (KWT). The KWT means the plug-in library implemented by Qt-based user interface development software. The main purpose of developing the KWT library is to implement full automation libraries having interface with the automated EPICS channel access (CA) guaranteeing the flexibility for requirements of operators. In addition, it has advantages in minimizing human code error and maximizing utilization of the limited human resource. According to the increasing of control systems, a number of OPI servers connected to one EPICS gateway server caused the connection problem and increased the amount of the network data packets. To solve these problems, an algorithm of “CachedChannelAccess” for shared memory base was implemented into an inner logic of the KWT library. KSTAR control system monitoring (CSM) program is one of applications developed by using KWT library. The function of CSM program is to notify alarm to operators by checking health status of every server's network health status and resource (cpu, memory, network packets, disk usage rate and system/user defined process) usage state. Another application is a post-shot sequencing program which is activated after every shot is completed. This application is to display major plasma parameters and diagnostic data in chart form, to save this data to database, and to transfer a chart image file to a web server. This paper describes the technical details how to develop OPI applications which have high productivity using Qt on the EPICS-based control system.

  16. Międzyrzecki Rejon Umocniony – w oczekiwaniu na adaptacje i modernizacje

    Directory of Open Access Journals (Sweden)

    Bartosz Michalak

    2018-04-01

    W artykule przedstawiono historię oraz opis kompleksu a także propozycje adaptacji schronów na nowe cele. Istnieje kilka koncepcji a realizacja tych planów byłaby cenną inicjatywą związaną z ochroną tego wyjątkowego obszaru i znajdujących się na nim obiektów inżynierskich.

  17. Przykład utraty stateczności ściany frontowej pozostawionej po rozebraniu kamienicy

    Directory of Open Access Journals (Sweden)

    Janusz Laskowski

    2018-04-01

    Full Text Available W artykule przedstawiono opis ściany frontowej budynku pozostawionej po jego rozbiórce. Prowizoryczne zabezpieczenie tej ściany oraz wpływ czynników zewnętrznych, w tym geologicznych, przyczyniły się do utraty przez tę ścianę stateczności, co przy braku jakichkolwiek skutecznych zabezpieczeń może doprowadzić do katastrofy budowlanej.

  18. Comparative study between 2 methods of mounting models in semiadjustable articulator for orthognathic surgery.

    Science.gov (United States)

    Mayrink, Gabriela; Sawazaki, Renato; Asprino, Luciana; de Moraes, Márcio; Fernandes Moreira, Roger William

    2011-11-01

    Compare the traditional method of mounting dental casts on a semiadjustable articulator and the new method suggested by Wolford and Galiano, 1 analyzing the inclination of maxillary occlusal plane in relation to FHP. Two casts of 10 patients were obtained. One of them was used for mounting of models on a traditional articulator, by using a face bow transfer system and the other one was used to mounting models at Occlusal Plane Indicator platform (OPI), using the SAM articulator. After that, na analysis of the accuracy of mounting models was performed. The angle made by de occlusal plane and FHP on the cephalogram should be equal the angle between the occlusal plane and the upper member of the articulator. The measures were tabulated in Microsoft Excell(®) and calculated using a 1-way analysis variance. Statistically, the results did not reveal significant differences among the measures. OPI and face bow presents similar results but more studies are needed to verify its accuracy relative to the maxillary cant in OPI or develop new techniques able to solve the disadvantages of each technique. Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Gabapentina a dosis de 300 vs. 450 mg como premedicación anestésica para hipertensión reactiva, ansiedad y analgesia.

    Science.gov (United States)

    Rascón-Martínez, Dulce María; Guzmán-Sánchez, Joaquín Antonio; Corral-Urdapilleta, Nora Paulina; Arguelles-Uribe, Gema Damaris; Velázquez-Loeza, Jazmín; Soto-Palma, Gustavo; Carrillo-Torres, Orlando

    2018-01-01

    Observar el comportamiento de la gabapentina para aminorar la hipertensión reactiva secundaria a ansiedad y dolor en pacientes sometidos a cirugía oftálmica, así como el consumo de opiáceos entre los grupos. Ensayo clínico controlado aleatorizado y doble ciego que analizó a 125 pacientes divididos en tres grupos: grupo A, gabapentina 300 mg; grupo B, gabapentina 450 mg; grupo C, amaranto en grageas como control 2 horas antes del procedimiento quirúrgico. Se utilizó la prueba de ji al cuadrado para variables sociodemográficas y ANOVA de un factor para variables numéricas continuas. Se consideró como significativo un valor de p consumo de opiáceos en los grupos que usaron gabapentina. La gabapentina por vía oral, 300 o 450 mg, 2 horas antes de la cirugía, reduce el dolor, la ansiedad y el consumo de opiáceos durante el posoperatorio en pacientes sometidos a cirugía oftalmológica. Copyright: © 2018 SecretarÍa de Salud

  20. Development of wide area environment accelerator operation and diagnostics method

    Science.gov (United States)

    Uchiyama, Akito; Furukawa, Kazuro

    2015-08-01

    Remote operation and diagnostic systems for particle accelerators have been developed for beam operation and maintenance in various situations. Even though fully remote experiments are not necessary, the remote diagnosis and maintenance of the accelerator is required. Considering remote-operation operator interfaces (OPIs), the use of standard protocols such as the hypertext transfer protocol (HTTP) is advantageous, because system-dependent protocols are unnecessary between the remote client and the on-site server. Here, we have developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force for Web-based systems, as a next-generation Web-based OPI using the Experimental Physics and Industrial Control System Channel Access protocol. As a result of this implementation, WebSocket-based client systems have become available for remote operation. Also, as regards practical application, the remote operation of an accelerator via a wide area network (WAN) faces a number of challenges, e.g., the accelerator has both experimental device and radiation generator characteristics. Any error in remote control system operation could result in an immediate breakdown. Therefore, we propose the implementation of an operator intervention system for remote accelerator diagnostics and support that can obviate any differences between the local control room and remote locations. Here, remote-operation Web-based OPIs, which resolve security issues, are developed.

  1. Development of wide area environment accelerator operation and diagnostics method

    Directory of Open Access Journals (Sweden)

    Akito Uchiyama

    2015-08-01

    Full Text Available Remote operation and diagnostic systems for particle accelerators have been developed for beam operation and maintenance in various situations. Even though fully remote experiments are not necessary, the remote diagnosis and maintenance of the accelerator is required. Considering remote-operation operator interfaces (OPIs, the use of standard protocols such as the hypertext transfer protocol (HTTP is advantageous, because system-dependent protocols are unnecessary between the remote client and the on-site server. Here, we have developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force for Web-based systems, as a next-generation Web-based OPI using the Experimental Physics and Industrial Control System Channel Access protocol. As a result of this implementation, WebSocket-based client systems have become available for remote operation. Also, as regards practical application, the remote operation of an accelerator via a wide area network (WAN faces a number of challenges, e.g., the accelerator has both experimental device and radiation generator characteristics. Any error in remote control system operation could result in an immediate breakdown. Therefore, we propose the implementation of an operator intervention system for remote accelerator diagnostics and support that can obviate any differences between the local control room and remote locations. Here, remote-operation Web-based OPIs, which resolve security issues, are developed.

  2. Diffuse reflectance spectroscopy and optical polarization imaging of in-vivo biological tissue

    Science.gov (United States)

    Mora-Núñez, A.; Castillejos, Y.; García-Torales, G.; Martínez-Ponce, G.

    2013-11-01

    A number of optical techniques have been reported in the scientific literature as accomplishable methodologies to diagnose diseases in biological tissue, for instance, diffuse reflectance spectroscopy (DRS) and optical polarization imaging (OPI). The skin is the largest organ in the body and consists of three primary layers, namely, the epidermis (the outermost layer exposed to the world), the dermis, and the hypodermis. The epidermis changes from to site to site, mainly because of difference in hydration. A lower water content increase light scattering and reduce the penetration depth of radiation. In this work, two hairless mice have been selected to evaluate their skin features by using DRS and OPI. Four areas of the specimen body were chosen to realize the comparison: back, abdomen, tail, and head. From DRS, it was possible to distinguish the skin nature because of different blood irrigation at dermis. In the other hand, OPI shows pseudo-depolarizing regions in the measured Mueller images related to a spatially varying propagation of the scattered light. This provides information about the cell size in the irradiated skin.

  3. Acute Organophosphate Poisonings: Therapeutic Dilemmas and New Potential Therapeutic Agents

    International Nuclear Information System (INIS)

    Vucinic, S.; Jovanovic, D.; Vucinic, Z.; Todorovic, V.; Segrt, Z.

    2007-01-01

    It has been six decades since synthesis of organophosphates, but this chapter has not yet come to a closure. Toxic effects of organophosphates are well known and the current therapeutic scheme includes supportive therapy and antidotes. There is a dilemma on whether and when to apply gastric lavage and activated charcoal. According to Position Statement (by EAPCCT) it should be applied only if the patient presents within one hour of ingestion, with potentially lethal ingested dose. Atropine, a competitive antagonist of acetylcholine at m-receptors, which antagonizes bronchosecretion and bronchoconstriction, is the corner stone of acute organophosphate poisoning therapy. There were many attempts to find a more efficient drug, including glycopyrrolate which has been used even in clinical trials, but it still can not replace atropine. The only dilemma about atropine usage which still exists, concerns usage of high atropine dose and scheme of application. The most efficient atropinization is achieved with bolus doses of 1-2mg of atropine i.v push, with repeating the dose on each 5 minutes until signs of atropinization are registered. Diazepam, with its GABA stabilizing effect, reduces central nervous system damage and central respiratory weakness. Oximes reactivate phosphorylated acetylcholinesterase, which still has not gone ageing, reducing acetylcholine concentration and cholinergic crisis. These effects are clearly demonstrated in experimental conditions, but the clinical significance of oximes is still unclear and there are still those who question oxime therapy. For those who approve it, oxime dosage, duration of therapy, the choice of oxime for certain OP is still an open issue. We need new, more efficient antidotes, and those that are in use are only the small part of the therapy which could be used. Experimental studies show favorable therapeutic effect of many agents, but none of them has been introduced in standard treatment of OPI poisoning in the last 30

  4. Aquaculture and Fish Welfare: Are the Rights of Fish Compromised?/ Akwakultura I Dobrostan Ryb: Czy Prawa Ryb Są Szanowane?

    Directory of Open Access Journals (Sweden)

    Mustapha Moshood K.

    2014-12-01

    Full Text Available Zagadnienie dobrostanu ryb w akwakulturze jest aktualne przez cały proces produkcyjny, a jego właściwa realizacja, z poszanowaniem praw ryb i humanitarnym ubojem, jest korzystana dla producenta i konsumenta. Poszanowanie praw ryb odnosi się do różnorodnych aspektów hodowli uwzględniając takie jak: baseny i stawy hodowlane, zagęszczenie obsady, jakość wody, pokarm i reżim żywienia, zarażenie chorobami i pasożytami, metody leczenia ryb zarażonych, manipulacja ciałem ryby, odłowy sieciowe, metody pozyskiwania ryb przed ubojem, metody uboju, metody oczyszczania z pokarmu, sztuczny fotoperiod, selekcja w kierunku szybkiego wzrostu, selektywny i indukowany rozród, manipulacje genetyczne, ekspozycja na drapieżnictwo, hodowla w polikulturach, znakowanie, stłaczanie ryb, sortowanie, transport, rybie atraktory, przypadkowe bądź celowe introdukcje ryb modyfikowanych genetycznie do akwakultury. Najbardziej rekomendowaną metodą utrzymywania ryb w pożądanym dobrostanie, która zapewni też korzyści dla hodowcy jest zachowywanie tzw. „pięciu wolności” w odniesieniu do hodowanych zwierząt. Sposoby realizacji takiego prowadzenia hodowli są przedstawione i dyskutowane w niniejszej pracy. Stan ryb w niewoli powinien uwzględniać czynniki etyczne, produkcyjne, ekonomiczne i handlowe. Jest to coraz ważniejsze ze względu na rosnącą potrzebę konsumenta do zapoznania się z technikami stosowanymi w produkcji pożywienia pochodzenia zwierzęcego i akceptacji tych praktyk. Polepszenie dobrostanu produkowanych ryb w akwakulturze skutkuje zwiększeniem korzyści produkcyjnej: ryby będą przyrastać lepiej, a jakość mięsa będzie wyższa. Wzrasta też poziom akceptacji u konsumentów tak wyprodukowanego mięsa w powiązaniu z humani- tarnym ubojem.

  5. Rapid Epidemiological Assessment of Onchocerciasis in a Tropical Semi-Urban Community, Enugu State, Nigeria

    Directory of Open Access Journals (Sweden)

    JE Eyo

    2013-03-01

    Full Text Available Background: This study was carried out in Opi-Agu a tropical semi-urban autonomous community comprising of three villages in Enugu State, Nigeria, between the months of April and June 2010. It was designed to determine the prevalence of Onchocerca volvulus infection and assess the perception of the disease among the inhabitants of this community.Methods: A total number of 305 individuals comprising of 148 males and 157 females were ex­amined for various manifestations of onchocerciasis symptoms using rapid epidemiological assess­ment (REA method.Results: Out of this number, 119 (39.02% individuals were infected. Prevalence of infection among age groups and villages varied. Age group 41 yr and above had the highest (31.00% prevalence, while among the villages, Ogbozalla village ranked higher (45.71% than the other villages. Overall the prevalence of infection among the sexes revealed that males were more infected (43.24% than the females (35.03%. Lichenified onchodermatitis (LOD was the most prevalent (35.29% onchocercia­sis symptom among others identified in the area, while leopard skin (LS had the lowest (20.17% occurrence and blindness (0.00% which is the most devastating effect of O. volvulus infec­tion was not observed. Questionnaire responses from 410 individuals revealed that 34.8% respon­dent from Idi village and 28.1% from Ibeku village believed that O. volvulus infection occurs through poor personal hygiene. Bite of blackfly ranked least (10.6% among the respondent’s knowledge of the causes of onchocerciasis in Opi-Agu community.Conclusion: Opi-Agu community members had poor knowledge of onchocerciasis, the vector and of its etiologic organism. There is need for integration of community health education with mass chemo­therapy

  6. Developement of a large proton accelerator for innovative researches; development of low energy high current beam transport system

    Energy Technology Data Exchange (ETDEWEB)

    Ko, In Soo; Namkung, Won; Cho, M. H.; Kim, K. N.; Kim, J. H.; Bae, Y. S.; Kim, Y.; Kim, K. H.; Shim, K. Y. [Pohang University of Science and Technology, Pohang (Korea)

    2001-04-01

    We have designed the beam transport system to connect the ion source and the RFQ. In this design, we have finalized the positions of solenoids and various beam diagnostic device. We have finalize the physical and mechanical designs of solenoids, and these designs are already adopted to produce the actual solenoids. We have also studied about EPICS, Experimental Physics and Industrial Control System, to control a stepper motor as a tuner of the RFQ designed for KOMACEPICS is a real time control system for a large scale system such as accelerators and tokamaks. The purpose of this thesis is to establish a test system based on the EPICS. A Sun UtraSPARC 5 workstation is used as the Operator Interface(OPI) console, and a VME chassis contained a Motorola MVME162 single board computer is used as the Input/Output Controller(IOC). A stepper motor controller is connected to the IOC via an RS-232C as a field bus. The EPICS base, extensions, and the real time OS vxWorks are installed on the workstation. The real time OS image can be downloaded to the IOC via the FTP when the test station is started. We have installed an IOC application as a device and driver support layer for the serial communication with an RS-232C on the workstation. We have designed the IOC database configuration files and a graphic user interface style OPI panel which was programmed by the MEDM. With this OPI, we can control the stepper motor using EPICS. 17 refs., 33 figs., 9 tabs. (Author)

  7. Pobreza, movimiento social y mujer

    Directory of Open Access Journals (Sweden)

    Elsa Patiño Tovar

    2005-01-01

    Full Text Available Los movimientos sociales en Puebla se han nutrido ampliamente de la participación de las mujeres; sobre todo, cuando hablamos de las organizaciones populares independientes (OPI. Su participación ha mantenido vivas a muchas organizaciones que de otra manera habrían desaparecido ya, pues no sólo participan en las tareas cotidianas de la organización sino, también, son las primeras en dar la cara cuando hay enfrentamientos con el gobierno y sus organizaciones corporativas, en donde han repelido agresiones incluso violentas. Sin embargo, a pesar de que las OPI se compongan en 90% por mujeres, sus líderes son hombres y ellas son base, no dirigencia. El machismo se mantiene en la mentalidad de ellos… y de ellas, que aceptan que sean los hombres quienes tomen las riendas, porque ellas se sienten inseguras para encabezar a la organización y, además, las tareas del hogar tampoco se los permiten. La lucha de la mujer por sus derechos ha tenido un fuerte impacto internacional, pero tal parece que en las OPI de Puebla este proceso no ha logrado penetrar lo suficiente como para romper los propios límites que se ha impuesto la mujer por una larga tradición que la atrapa en su papel de esposa y ama de casa. En este artículo nos interesa explorar las razones por las que la participación en los movimientos sociales ha permitido que la mujer comprenda su situación, pero no la ha inducido a modificarla.

  8. Effect of Hartha and Najibia power plants on water quality indices of Shatt Al-Arab River, south of Iraq

    Science.gov (United States)

    Al-Aboodi, Ali H.; Abbas, Sarmad A.; Ibrahim, Husham T.

    2018-05-01

    The main object of this research is to assess the water quality of Shatt Al-Arab River and its suitability for various purposes near power plants (Hartha and Najibia) through physical and chemical analysis [temperature, pH, EC, Cl-, Na+, K+, Ca+2, Mg+2, HCO3 -, NO3 -, SO 4 -2 , Fe+, total alkalinity, total hardness, biological oxygen demand (BOD5), NH4 +, and NO2 -] using water quality index (WQI), organic pollution index (OPI), sodium adsorption ratio (SAR), and percentage of sodium ion (Na%) during the dry season (August, 2016) and the wet season (January, 2017). WQI of Shatt Al-Arab falls under very poor quality during summer season, while it ranges from very poor quality to unsuitable for drinking purposes during winter season. There is a clear effect of power plants on water quality. Hartha and Najibia power plants contribute to the deterioration of water quality by increasing the percentage ratio of WQI near these plants by 13.22 and 9.69%, respectively, compared to the north sites of these plants during summer season. The percentage ratios of increased WQI near Hartha and Najibia power plants compared to the north sites of these plants are 17.93 and 15.92%, respectively, during winter season. Water quality of Shatt Al-Arab falls under a high level of organic pollution during the summer and winter seasons. There is a slight effect by the power plants on the OPI. Hartha and Najibia power plants contributed to the change of the OPI by 10% compared to the north site of Hartha power plant. According to the comparison between the SAR values which represent the suitability of water for serve irrigation purposes and SAR values of Shatt Al-Arab, all sites lie in the first class (excellent). According to Na+%, the type of surface water in the studied area lies in good class during winter season and permissible class during summer season.

  9. Survival prediction algorithms miss significant opportunities for improvement if used for case selection in trauma quality improvement programs.

    Science.gov (United States)

    Heim, Catherine; Cole, Elaine; West, Anita; Tai, Nigel; Brohi, Karim

    2016-09-01

    Quality improvement (QI) programs have shown to reduce preventable mortality in trauma care. Detailed review of all trauma deaths is a time and resource consuming process and calculated probability of survival (Ps) has been proposed as audit filter. Review is limited on deaths that were 'expected to survive'. However no Ps-based algorithm has been validated and no study has examined elements of preventability associated with deaths classified as 'expected'. The objective of this study was to examine whether trauma performance review can be streamlined using existing mortality prediction tools without missing important areas for improvement. We conducted a retrospective study of all trauma deaths reviewed by our trauma QI program. Deaths were classified into non-preventable, possibly preventable, probably preventable or preventable. Opportunities for improvement (OPIs) involve failure in the process of care and were classified into clinical and system deviations from standards of care. TRISS and PS were used for calculation of probability of survival. Peer-review charts were reviewed by a single investigator. Over 8 years, 626 patients were included. One third showed elements of preventability and 4% were preventable. Preventability occurred across the entire range of the calculated Ps band. Limiting review to unexpected deaths would have missed over 50% of all preventability issues and a third of preventable deaths. 37% of patients showed opportunities for improvement (OPIs). Neither TRISS nor PS allowed for reliable identification of OPIs and limiting peer-review to patients with unexpected deaths would have missed close to 60% of all issues in care. TRISS and PS fail to identify a significant proportion of avoidable deaths and miss important opportunities for process and system improvement. Based on this, all trauma deaths should be subjected to expert panel review in order to aim at a maximal output of performance improvement programs. Copyright © 2016 Elsevier

  10. EPICS channel access using websocket

    International Nuclear Information System (INIS)

    Uchiyama, A.; Furukawa, K.; Higurashi, Y.

    2012-01-01

    Web technology is useful as a means of widely disseminating accelerator and beam status information. For this purpose, WebOPI was implemented by SNS as a web-based system using Ajax (asynchronous JavaScript and XML) with EPICS. On the other hand, it is often necessary to control the accelerator from different locations as well as the central control room during beam operation and maintenance. However, it is not realistic to replace the GUI-based operator interface (OPI) with a Web-based system using Ajax technology because of interactive performance issue. Therefore, as a next generation OPI over the web using EPICS Channel Access (CA), we developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force (IETF) for Web-based systems. WebSocket is a web technology that provides bidirectional, full-duplex communication channels over a single TCP connection. By utilizing Node.js and the WebSocket access library called Socket.IO, a WebSocket server was implemented. Node.js is a server-side JavaScript language built on the Google V8 JavaScript Engine. In order to construct the WebSocket server as an EPICS CA client, an add-on for Node.js was developed in C/C++ using the EPICS CA library, which is included in the EPICS base. As a result, for accelerator operation, Web-based client systems became available not only in the central control room but also with various types of equipment. (author)

  11. The effects of different pre-game motivational interventions on athlete free hormonal state and subsequent performance in professional rugby union matches.

    Science.gov (United States)

    Cook, Christian J; Crewther, Blair T

    2012-07-16

    We examined the effect of different pre-match motivational interventions on athlete free testosterone (T) and cortisol (C) concentrations and subsequent match performance in professional rugby union. Male participants (n=12) playing at a senior or academy level in rugby union were recruited and each completed three interventions (15 min each) before a competitive game; 1) watching a video clip of successful skill execution by the player with positive coach feedback [VPCF1]; 2) watching a video clip of successful skill execution by an opposing player with cautionary coach feedback [VCCF], 3) the player left alone to self-motivate [SM1]. The first and last interventions were retested [VPCF2 and SM2]. Salivary free T and C measures were taken pre-intervention and pre-game. Within each game, players were rated by coaching staff on a key performance indicator (KPI) from identified skills and an overall performance indicator (OPI), where 1 = best performance to 5 = worst performance. The VPCF1 and VPCF2 interventions both promoted significant T responses (11.8% to 12.5%) before each game and more so than SM1, SM2 and VCCF. The VCCF approach produced the largest C response (17.6%) and this differed from all other treatments. The VPCF interventions were also associated with better game KPI (1.5 to 1.8) and OPI ratings (1.7 to 1.8) than SM1, SM2 and/or VCCF. Across all treatments, greater individual T responses and lower C responses were associated with better KPI and OPI outcomes. In conclusion, the pre-game presentation of motivational strategies to athletes involving specific video footage and coach feedback produced different outcomes on two indicators of match performance, which were also associated with changes in free hormonal state. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Uporaba hipnoze pri preiskovanju kaznivih dejanj

    OpenAIRE

    Radić, Janja

    2016-01-01

    V svojem diplomskem delu predstavljam tehniko hipnoze kot metodo za izboljšanje spomina pri pričah in žrtvah kaznivih dejanj. Posvetim se pojmovanju in uporabi hipnoze skozi zgodovino, nato pa podam še njeno definicijo in tehnike. Poleg načina uporabe hipnoze pri preiskovanju kaznivih dejanj, predstavim tudi njene prednosti in slabosti, opišem potek hipnotiziranja ter vlogo in funkcijo hipnotizerja. V zadnjih dveh poglavjih pojasnim vpliv spomina na hipnotične informacije ter predstavim pravn...

  13. RA Reactor; Reaktor RA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-07-01

    This chapter includes the following: General description of the RA reactor, organization of work, responsibilities of leadership and operators team, regulations concerning operation and behaviour in the reactor building, regulations for performing experiments, regulations and instructions for inserting samples into experimental channels. [Serbo-Croat] Ovo (prvo) poglavlje sadrzi sledece: Opis reaktora RA; semu organizacije rada i rukovodjenja; prava i duznosti direktora i rukovodioca pogona reaktora, propise o rezimu rada i kretanja u zgradi reaktora, propise o izvodjenju eksperimenata, propise o unosenju uzoraka u eksperimentalne kanale reaktora.

  14. Command History. 1972-1973. Volume 2. Sanitized

    Science.gov (United States)

    1973-07-15

    was de - ing processing Army DEROS flights, transporting veloped to handle the anticipated large number of baggage to and from the flight lines, and...VOLUME 11 B CIA IFIED CY 1 PAC F0 IG D EMN 0 EXE TED IF AMA NERA DE LASSIF A N EXEM E SY CINC CC \\’ opy ot󈨤 Cop~ies Iys BTAG pT ’’, 00- d 6,,’ 83-6 6-24...it nocoaam7 &WE Identity by black aiimiiw) Logistica , Support of RVNAF. Communications-Electronics, VNAF Support, Command Activities, The New Agencies

  15. Možnosti prihrankov električne energije pri cestni razsvetljavi, ki se prilagaja količini prometa

    OpenAIRE

    BAVČAR, JERNEJ

    2018-01-01

    V diplomskem delu sem predstavil način in predlog, kako zmanjšati stroške porabe električne energije in svetlobno onesnaževanje z javno razsvetljavo. Pri analizi podatkov sem si pomagal s programom MATLAB. Dobljene vrednosti sem nato obdelal v programskem orodju MS Excel. Na začetku najprej preletim zgodovino razvoja umetne razsvetljave in razvoja javne razsvetljave v Sloveniji in svetu. Za tem opišem veljavne zahteve glede javne razsvetljave in elemente, ki so upoštevani pri načrtovanju n...

  16. RAZVOJ APLIKACIJE ZA UPRAVLJANJE SLIK IN ALBUMOV NA MOBILNI PLATFORMI ANDROID

    OpenAIRE

    Kupnik, Domen

    2012-01-01

    V okviru diplomske naloge smo izdelali mobilno aplikacijo na operacijskem sistemu Android OS za upravljanje slik in albumov. V teoretičnem delu smo najprej predstavili že obstoječe podobne aplikacije. Nato smo se seznanili z arhitekturo operacijskega sistema Android OS in s kompletom za razvijanje aplikacij Android SDK. V nadaljevanju sledi še predstavitev lokacijskega podsistema Google Map ter podrobnejši opis uporabljenih funkcionalnosti. V praktičnem delu prikažemo implementacijo aplikacij...

  17. Povezanost socioloških in psiholoških dejavnikov z nakupnim vedenjem in vključevanjem odjemalcev, v personalizirano marketinško komunikacijsko kampanjo, Ta Coca-Cola je zate

    OpenAIRE

    Mujagić, Selvedin

    2018-01-01

    V magistrskem delu predstavljamo področje marketinga vključevanja odjemalcev, enega izmed sodobnih marketinških pristopov, ki se izvaja kot marketinška in spletna strategija za načrtovanje in upravljanje vedenja odjemalcev. Magistrsko delo je sestavljeno iz uvodnega dela, teoretične obravnave, raziskovalnega dela, predlogov menedžmentu in sklepa naloge. Uvodni del magistrske naloge se nanaša na opis področja vedenja odjemalcev, integriranega marketinškega komuniciranja in vključevalnega v...

  18. Študija uporabnosti računalniških simulacij in animacija oblačil za potrebe manjših podjetij

    OpenAIRE

    Slakonja, Andreja

    2016-01-01

    Namen diplomskega dela je bil preučiti uporabnost računalniške simulacije in animacije oblačila za potrebe manjšega podjetja, izdelati kroj, simulacijo in animacijo oblačila na virtualnem parametričnem modelu v programu Marvelous Designer 3 ter zašiti realni model oblačila in ju primerjati. Nadalje je bil namen izdelati spletno stran za modno oblikovalko Barbaro F. V uvodnem delu je opisano modno oblikovanje in konstrukcija oblačil ter predstavitev oblikovalke Barbare F. V nadaljevanju so opi...

  19. Report on works on the CEN-132 pump Avala - Annex 6; Prilog 6 - Izvestaj o radovima na pumpi CEN-132 Avala zavodski broj 6

    Energy Technology Data Exchange (ETDEWEB)

    Bratic, A [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1963-12-15

    This report describes in detail the action of opening and taking apart the heavy water pump CEN-132 in order to take out the rotor with damaged surfaces. Total number of 11 workers were involved each spending not more than 30 minutes in the room for safety reasons. [Serbo-Croat] Oaj izvestaj sadrzi detaljan opis postupaka prilikom otvaranja i rastavljanja delova pumpe CEN-132 sa cijlem da se izvuce rotor cije su povrsine ostecene. U radovima je ucestvovalo ukupno 11 mehanicara, koji su se zadrzavali u prostoriji pumpe do 30 minuta iz razloga sigurnosti.

  20. Supplemental Environmental Assessment for the Nuclear and Space Security Tactics Training Center Project AFSPC053012 for Air Force Security Forces at Camp Guernsey, Wyoming

    Science.gov (United States)

    2010-02-01

    8217Ŕ IPACE: lfCUNTY TACTlet lRAINIIIG CI! NT1 !IIt (NIITTC) /lllfll!tA DI!W!l.OPI&I!NT JI\\AH c co -c._ -.; Q) ~::: Ill~ +-’ ~~ ·- ~~ (f) ti li LA N...Manager WMD- CFMO 3919 Central Ave. Cheyenne, WY 82001 (307) 772-5066 (o) (307) 274-0844 ( cell ) --- - -Original Message----- From: Lloyd, Dee W Mr...772-5066 (o) (307) 274-0844 ( cell ) -----Original Message----- From: Pesenti, Cathryn M Civ USAF AFGSC 90 CES/CEV [mailto:Cathryn.Pesenti@warren

  1. Serum cortisol and blood glucose in bitches treated with tramadol and submitted to ovariohysterectomy

    OpenAIRE

    Caldeira, Fátima Maria Caetano; Oliveira, Humberto Pereira; Melo, Eliane Gonçalves; Martins, Claudia; Vieira, Marilisa Souza; Silva, Cristiano Nicomedes da

    2006-01-01

    O tramadol é um analgésico opióide usado em medicina veterinária, embora existam poucos estudos sobre este fármaco. O objetivo deste trabalho foi avaliar o efeito analgésico promovido pela administração do tramadol, mensurando o cortisol sérico e a glicemia de cadelas. Para isso, foram utilizadas 15 fêmeas, submetidas a ovário-histerectomia sob anestesia geral com isofluorano. Os animais foram divididos em três grupos. Grupo 1 (Tep) receberam tramadol pela via epidural (1,0mg kg-1 diluído em ...

  2. Cortisol sérico e glicemia em cadelas tratadas com tramadol e submetidas à ovário-histerectomia

    OpenAIRE

    Caldeira Fátima Maria Caetano; Oliveira Humberto Pereira; Melo Eliane Gonçalves; Martins Claudia; Vieira Marilisa Souza; Silva Cristiano Nicomedes da

    2006-01-01

    O tramadol é um analgésico opióide usado em medicina veterinária, embora existam poucos estudos sobre este fármaco. O objetivo deste trabalho foi avaliar o efeito analgésico promovido pela administração do tramadol, mensurando o cortisol sérico e a glicemia de cadelas. Para isso, foram utilizadas 15 fêmeas, submetidas a ovário-histerectomia sob anestesia geral com isofluorano. Os animais foram divididos em três grupos. Grupo 1 (Tep) receberam tramadol pela via epidural (1,0mg kg-1 diluído em ...

  3. KOMUNIKACIJA IN VIZUALNA KOMUNIKACIJA

    OpenAIRE

    Petrena, Polona

    2013-01-01

    Področja komunikacije, vizualne komunikacije in psihologije komunikacije so med seboj tesno povezana in so neizbežni dejavniki našega vsakdanjega življenja. Diplomsko delo zajema opis dejstev ter ugotovitev za našteta področja in razjasnjuje razlike med besedno in nebesedno komunikacijo ter predelavo kognitivnih sporočil. Ugotovili smo, da ljudje že od nekdaj upodabljamo svoje ideje, sporočila in da smo močno dovzetni za vse oblike komunikacije. Na naše razumevanje in dojemanje sporočil pa im...

  4. Kuuntele ja osallistu - Sosiaalinen media myynnin ja markkinoinnin tukena

    OpenAIRE

    Lönnblad, Hanna

    2010-01-01

    Sosiaalinen media on tullut jäädäkseen. Viimeisen kymmenen vuoden aikana IRC-Gallerian, Habbo Hotelin ja Facebookin kaltaiset palvelut ovat omineet itselleen kasvavan osan nykyihmisen ajankäytöstä niin töissä, kouluissa kuin vapaa-ajalla. Sosiaalisen median palveluita pidetään teinien leikkipaikkoina, mutta tosiasiassa uusi media tarjoaa rajattomasti potentiaalia myös yritystoiminnan kehittämiseen ja kasvattamiseen kaiken-kokoisille yrityksille. Virtuaalista maailmaa ei tule väheksyä. Opi...

  5. Napredni načini analize gesel in analiza lastnosti gesel slovenskih uporabnikov

    OpenAIRE

    Paulin, Primož

    2016-01-01

    V diplomski nalogi opišemo tipe gesel, njihov pomen in namene uporabe. Predstavimo načine shranjevanja gesel ter najpogostejše metode napadov na gesla. V nadaljevanju obravnavamo tehnike razbijanja gesel in za to potrebna orodja ter principe. Z izvedbo praktičnega razbijanja gesel s pomočjo mavričnih tabel predstavimo prednosti razbijanja gesel z grafično procesno enoto v primerjavi z osrednjo procesno enoto. S pomočjo vzorcev gesel slovenskih uporabnikov, zbranih v anketi, analiziramo navade...

  6. Kako močna so dejanska gesla študentov - zgodovinska analiza

    OpenAIRE

    Makari, Tadej

    2017-01-01

    V magistrskem delu opišemo zgodovino prve uporabe računalniških gesel, tipe gesel in njihove značilnosti. Predstavimo metode oblikovanja močnega gesla in načine varnega shranjevanja gesel ter osnovne tehnike napadov na gesla. S pomočjo programskega orodja Hashcat se lotimo praktičnega razbijanja študentskih gesel na podlagi tehnike napada z grobo silo in s slovarjem. Iz rezultatov razbijanja izdelamo končni seznam pridobljenih gesel, na podlagi katerega izvedemo osnovno analizo gesel, ki teme...

  7. Development of Methods for Analysis of the Cost of Enlisted Attrition

    Science.gov (United States)

    1977-09-01

    l_J _J JZU 3 cui< x lura. V c © o zciri’O’Cccr^—tötete iTcnjcipr^fOKic^r* — ^)co«37- ctor*i—rvo-o-c- >oa5—OJKI-AJ rococo O... rococo —ru^^aun^or^ cc « O —-"•-•-•—---"-"—-"furvji\\jr\\jnjf\\jiMr\\;(Mr\\jKimr^i^rnKiKiKihnK»=TO^ 5T5»=3 ^^^ « X. B-l-35 >.«o -opi»?o» o—*^*r^r ri/> o

  8. Instructions for RA reactor decontamination - Annex 10; Prilog 10 - Uputstvo za dekontaminaciju Reaktora RA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1963-12-15

    Instructions for RA reactor decontamination includes: action plan for decontamination of the heavy water system by 7% water solution of H{sub 3}PO{sub 4} + 2% CrO{sub 3} acid; description of the preparatory work including calculation of the pipes volume and installation of special pipes; detailed instructions for decontamination procedure. [Serbo-Croat] Uputstvo za dekontaminaciju Reaktora RA sadrzi: plan operacija za dekontaminaciju sistema teske vode 7% vodenim rastvorom kiseline H{sub 3}PO{sub 4} + 2% CrO{sub 3}; opis pripremnih radova ukljucujuci proracun zapremine covovoda i montiranje posebnih cevovoda; detaljno uputstvo za izvodjenje operacija pri dekontaminaciji.

  9. Ophiuroidea das regiões antártica e subantártica: 1. sobre três espécies de Gorgonocephalidae e Ophiacanthidae Ophiuroidea from antarctic and subantarctic regions: 1. on three species of Gorgonocephalidae and Ophiacanthidae

    Directory of Open Access Journals (Sweden)

    Ana Maria Gouveia Monteiro

    1983-01-01

    Full Text Available É estudada a distribuição geográfica e a variação de caracteres morfológicos de três espécies de ofiuroides (OpiLacantha antartica, Astrotoma agassizzi e Gorgonecephalus chilensis das regiões Antártica e Subantãrtica. São também apresentadas observações sobre biologia reprodutiva.The geographical distribution and the variation of morphological characters of three (Gorgonecephalus chilensis, Astroma agassizii, Ophiacantha antartica from the Antarctic and Subantarctic regions are studied. Observations on reproductive biology are presented.

  10. APLIKACIJA ZA PRIKAZ SLEDENJA VOZIL NA OPERACIJSKEM SISTEMU iOS

    OpenAIRE

    Mlinar, Tilen

    2011-01-01

    V diplomski nalogi prikazujemo razvoj aplikacije za operacijski sistem iOS. Razvili smo aplikacijo za sledenje vozil. V teoretičnem delu se najprej seznanimo z operacijskim sistemom iOS ter njegovo arhitekturo, nato predstavimo arhitekturo aplikacij iOS. Sledi opis kompleta razvojnih orodij v iOS SDK. V nadaljevanju se seznanimo še s programskim jezikom Objective-C, lokacijsko odvisnimi storitvam, podsistemom MapKit in delovanjem aplikacije v ozadju operacijskega sistema. V praktičnem delu op...

  11. One-way data transfer for PLC to VME status reporting at the Advanced Photon Source

    International Nuclear Information System (INIS)

    Stein, S.J.

    1993-01-01

    The Personnel Safety System for the experimental beamlines at the Advanced Photon Source will use a large number of Allen Bradley Programmable Logic Controllers (PLC) to replace conventional relay logic. PLCs allow for the design of a very advanced safety system that can handle a large number of I/O points. Certain situations Require monitoring of the safety system from various locations around the storage ring via EPICS OPI (operator interface)consoles. This presentation covers the method of choice for transferring data from the Personnel Safety System into an EPICS database. Specifics on PLC ladder design, EPICS database design, and hardware selection are also discussed

  12. Evaluación de la actividad hipotensora del Maytenus Krukovii (Chuchuhuasi) en rata consciente.

    OpenAIRE

    Salazar Granara, Alberto; Milla Flores, Diana Rosa; Morales Gutiérrez, Valeria; Velarde Barrantes, Luis Fernando; Villanueva Espinoza, Alan Alexis; Segura Carrillo, Karla; Casquero Del Castillo, Diego; Vargas Pareja, Yisella; Vela Gonzáles, Yliana; Sánchez Alarcón, Vanessa; Manrique Mejia, Renán

    2008-01-01

    Maytenus krukovii (chuchuhuasi), oriunda de la amazonia sudamericana, tradicionalmente se le atribuye acción analgésica, antiinflamatoria, afrodisíaca entre otros; investigaciones reportan acción analgésica con intermediación de receptores opiáceos, efecto antipirético, antiinflamatorio y gastroprotector. El presente estudio experimental indagó acerca de la acción sobre la presión arterial y frecuencia cardiaca del chuchuhuasi en rata consciente. Se utilizaron 10 ratas albinas machos, a las q...

  13. E-KAUPPAPORTAALIN MAHDOLLISUUDET PK-YRITYKSELLE

    OpenAIRE

    Järvenpää, Juho

    2011-01-01

    Opinnäytetyön aiheena oli tutkia e-kauppaportaalin mahdollisuuksia ja hyötyjä pk-yritykselle. Opinnäytetyön tarkoituksena oli tarjota pk-yrityksille tietoa, miksi e-kauppaportaalin käyttöönotto olisi varteen otettava vaihtoehto, kun yritys harkitsee verkkokaupan perustamista. Opinnäyte jakaantuu teorioiden ja tutkimusten esittelyyn ja niiden soveltamiseen pk-yrityksen hyväksi. Opinnäytetyössä käytettiin hyväksi Tieken tutkimuksia ja muita e-kauppaan liittyviä tutkimuksia ja teorioita. Opi...

  14. STILISTIKA DISKURSA KAO KONTEKSTUALIZIRANA STILISTIKA

    OpenAIRE

    Katnić-Bakaršić, Marina

    2004-01-01

    Rad posmatra diskursnu stilistiku kao kontekstualiziranu disciplinu, pri čemu kontekst podrazumijeva različite faktore (sociohistorijske, kognitivne, kulturalne i intertekstualne). U radu se proučavaju najznačajniji pristupi diskursnoj stilistici: prag,atička stilistika, konverzacijska i/ ili diskurs analiza, kognitivna stilistika, kritička stilistika, feministička stilistika. Naglašava se da je u diskursnoj stilistici analiza uvijek kombinirana sa interpretacijom, a opis je praćen objašnjenj...

  15. Future Role for Women in the Armed Forces

    Science.gov (United States)

    1976-11-18

    third very dramatic change in the United States military establishment today. We feel it in the Army as a matter of urgency , and that is a very...FOR OTHER INTRAMURAL OF INTERCOLLEGIATE CONTACT SPORTS SUCH AS FOOTBALL OR LACROSSE. HOWEVER, INTRAMURAL SOCCER IS A CONTACT SPORT WHICH HAS BEEN...itttOitAJION A,-ECUI 1 . ." (IO.VN 1 SO-PA) DEPARMENT OF OEENSE Dear Colonel Dion: Enclosed in opy of my rport on my visit to the U.S. Nval Academy whichI

  16. UPORABA TEHNOLOGIJE NFC V PODPORNIH ŽIVLJENJSKIH OKOLJIH

    OpenAIRE

    Kosem, Borut

    2016-01-01

    V diplomskem delu je predstavljena brezžična tehnologija kratkega dosega NFC in njena uporaba. Namen diplomskega dela je prikazati možnost uporabe tehnologije NFC na različnih področjih v vsakdanjem življenju. Na začetku je nekaj besed namenjenih zgodovini in razvoju tehnologije NFC, na kratko je predstavljenih nekaj sorodnih brezžičnih radijskih tehnologij. Sledi opis tehnologije, radijskih signalov in signalnih vmesnikov ter delovanja naprav in značk NFC. Predstavljene so možnosti uporabe z...

  17. OPIÁCEOS: MECANISMOS DE ACCIÓN, METABOLISMO, Y RELACIÓN CON EL SÍNDROME DE ABSTINENCIA NEONATAL

    OpenAIRE

    Osorio, José Henry

    2009-01-01

    Los niños expuestos a ciertas drogas in utero, pueden resultar físicamente dependientes de estas, sufriendo después del nacimiento síntomas de abstinencia, lo que se denomina síndrome de abstinencia neonatal (NAS). Los niños con NAS presentan disfunción multisistémica, que involucra los sistemas nervioso, gastrointestinal y respiratorio. La presente revisión analiza la literatura disponible, relacionada con el consumo de opiáceos por la madre gestante y el síndrome de abstinencia neonatal. ...

  18. Lepotna tekmovanja in varstvo otrokovih pravic

    OpenAIRE

    Rajh, Špela

    2017-01-01

    Temeljno načelo Konvencije Združenih narodov o otrokovih pravicah in Zakona o zakonski zvezi in družinskih razmerjih je načelo koristi otroka, ki je osnovno vodilo za ravnanje in postopanje staršev, institucij ter državnih organov, pri vseh dejavnostih, ki zadevajo otroka. Diplomsko delo je sestavljeno iz dveh delov. Prvi zajema pojem otroka in opis otrokovih pravic. Bistvena novost, ki jo prinaša KOP, je, da priznava otrokom tudi svoboščine. Svoboščine so posebna vrsta pravic do svobode...

  19. Preprosto aktivno varovanje elektronskih naprav pred prenapetostjo zaradi udara strele z uporabo detektorja strele AS3935

    OpenAIRE

    Golob, Uroš

    2016-01-01

    V diplomskem delu predstavljamo življenjski cikel prototipa od ideje do delujoče naprave, ki poskuša z uporabo senzorja za zaznavo strele proizvajalca AMS AS3935 Franklin Lightning Sensor preprečiti nepotrebno škodo na elektronskih napravah. V teoretičnem delu opišemo pojav strele in obstoječe rešitve na področju varovanja pred prenapetostmi. Razvoja prototipa smo se lotili po temeljitem pregledu razvojnih platform ter izbrali najprimernejšo za razvoj naprave s senzorjem za zaznavanje strel. ...

  20. A Phase Space Monitoring of Injected Beam of J-PARC MR

    Science.gov (United States)

    Hatakeyama, Shuichiro; Toyama, Takeshi

    Beam power of J-PARC MR (30 GeV Proton Synchrotron Main Ring) has been improved since 2008 and now achieved over 200 kW for the user operation. A part of beam loss is localized at the beam injection phase so it is important to monitor the beam bunch behavior in the transverse direction. In this paper it is described the method how to measure the position and momentum for each injected beam bunch using Beam Position Monitors (BPMs). It is also mentioned some implementation of an operator's interface (OPI) to display the plots of injected and circulating beam bunches in phase space coordinate.

  1. Overexpression of the NADP+-specific isocitrate dehydrogenase gene (icdA) in citric acid-producing Aspergillus niger WU-2223L.

    Science.gov (United States)

    Kobayashi, Keiichi; Hattori, Takasumi; Hayashi, Rie; Kirimura, Kohtaro

    2014-01-01

    In the tricarboxylic acid (TCA) cycle, NADP(+)-specific isocitrate dehydrogenase (NADP(+)-ICDH) catalyzes oxidative decarboxylation of isocitric acid to form α-ketoglutaric acid with NADP(+) as a cofactor. We constructed an NADP(+)-ICDH gene (icdA)-overexpressing strain (OPI-1) using Aspergillus niger WU-2223L as a host and examined the effects of increase in NADP(+)-ICDH activity on citric acid production. Under citric acid-producing conditions with glucose as the carbon source, the amounts of citric acid produced and glucose consumed by OPI-1 for the 12-d cultivation period decreased by 18.7 and 10.5%, respectively, compared with those by WU-2223L. These results indicate that the amount of citric acid produced by A. niger can be altered with the NADP(+)-ICDH activity. Therefore, NADP(+)-ICDH is an important regulator of citric acid production in the TCA cycle of A. niger. Thus, we propose that the icdA gene is a potentially valuable tool for modulating citric acid production by metabolic engineering.

  2. Preparation of Simulated LBL Defects for Round Robin Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, Charles A [ORNL; Hunn, John D [ORNL; Montgomery, Fred C [ORNL

    2016-01-01

    A critical characteristic of the TRISO fuel design is its ability to retain fission products. During reactor operation, the TRISO layers act as barriers to release of fission products not stabilized in the kernel. Each component of the TRISO particle and compact construction plays a unique role in retaining select fission products, and layer performance is often interrelated. The IPyC, SiC, and OPyC layers are barriers to the release of fission product gases such as Kr and Xe. The SiC layer provides the primary barrier to release of metallic fission products not retained in the kernel, as transport across the SiC layer is rate limiting due to the greater permeability of the IPyC and OPyC layers to many metallic fission products. These attributes allow intact TRISO coatings to successfully retain most fission products released from the kernel, with the majority of released fission products during operation being due to defective, damaged, or failed coatings. This dominant release of fission products from compromised particles contributes to the overall source term in reactor; causing safety and maintenance concerns and limiting the lifetime of the fuel. Under these considerations, an understanding of the nature and frequency of compromised particles is an important part of predicting the expected fission product release and ensuring safe and efficient operation.

  3. A Study on the Frequency of Initiating Event of OPR-1000 during Outage Periods

    Energy Technology Data Exchange (ETDEWEB)

    Hong Jae Beol; Jae, Moo Sung [Hanyang Univ., Seoul (Korea, Republic of)

    2013-10-15

    These sources of data did not reflect the latest event data which have occurred during the PWR outage to the frequencies of initiating event Electric Power Research Institute(EPRI) in USA collected the data of loss of decay heat removal during outage from 1989 to 2009 and published technical report. Domestic operating experiences for LOOP is gathered in Operational Performance Information System for Nuclear Power Plant(OPIS). To reduce conservatism and obtain completeness for LPSD PSA, those data should be collected and used to update the frequencies. The frequencies of LOSDC and LOOP are reevaluated using the data of EPRI and OPIS in this paper. Quantification is conducted to recalculate core damage frequency(CDF), since the rate is changed. The results are discussed below. To make an accurate estimate of the initiating events of LPSD PSA, the event data were collected and the frequencies of initiating events were updated using Bayesian approach. CDF was evaluated through quantification. Δ CDF is -40% and the dominant contributor is pressurizer PSV stuck open event. The most of the event data in EPRI TR were collected from US nuclear power plant industry. Those data are not enough to evaluate outage risk precisely. Therefore, to reduce conservatism and obtain completeness for LPSD PSA, the licensee event report and domestic data should be collected and reflected to the frequencies of the initiating events during outage.

  4. The relevance, biases, and importance of digitising opportunistic non-standardised collections: A case study in Iberian harvestmen fauna with BOS Arthropod Collection datasets (Arachnida, Opiliones).

    Science.gov (United States)

    Merino-Sáinz, Izaskun; Torralba-Burrial, Antonio; Anadón, Araceli

    2014-01-01

    In this study, we analyse the relevance of harvestmen distribution data derived from opportunistic, unplanned, and non-standardised collection events in an area in the north of the Iberian Peninsula. Using specimens deposited in the BOS Arthropod Collection at the University of Oviedo, we compared these data with data from planned, standardised, and periodic collections with pitfall traps in several locations in the same area. The Arthropod Collection, begun in 1977, includes specimens derived from both sampling types, and its recent digitisation allows for this type of comparative analysis. Therefore, this is the first data-paper employing a hybrid approach, wherein subset metadata are described alongside a comparative analysis. The full dataset can be accessed through Spanish GBIF IPT at http://www.gbif.es:8080/ipt/archive.do?r=Bos-Opi, and the metadata of the unplanned collection events at http://www.gbif.es:8080/ipt/resource.do?r=bos-opi_unplanned_collection_events. We have mapped the data on the 18 harvestmen species included in the unplanned collections and provided records for some species in six provinces for the first time. We have also provided the locations of Phalangium opilio in eight provinces without published records. These results highlight the importance of digitising data from unplanned biodiversity collections, as well as those derived from planned collections, especially in scarcely studied groups and areas.

  5. Pyridine-2,6-diyl dinitroxides as room-temperature triplet ligands

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Hinako; Tonegawa, Asato; Ishida, Takayuki, E-mail: takayuki.ishida@uec.ac.jp [Department of Engineering Science, The University of Electro-Communications, Tokyo (Japan)

    2016-02-01

    We have proposed tert-butyl 2-pyridyl nitroxide radicals as a promising paramagnetic chelating ligand, where the direct radical-metal bond leads to strong magnetic interaction. We successfully synthesized and isolated PyBN derivatives (pyridine-2,6-diyl bis(tert-butyl nitroxides)). The molecular and crystal structures of the target biradicals, MesPyBN, AntPyBN and tBuOPyBN were determined from the X-ray crystal structure analysis, which possess mesityl, 9-anthryl and tert-butoxy groups at the 5-position of the pyridine ring, respectively. The ground triplet state was characterized by means of SQUID susceptometry for each compound. On heating, the χ{sub m}T values of all the PyBN derivatives increased and reached a plateau at ca. 1.0 cm{sup 3} K mol{sup −1} at 300 K. It implies that biradicals behaved as triplet molecules even at room temperature, or 2J/k{sub B} >> 300 K. From the decay monitored in solution electron-spin resonance spectroscopy, MesPyBN was the most persistent, while tBuOPyBN was the most reactive, of the three.

  6. Spectro radiometry Applied to Soil Science; Espectrorradiometria Aplicada a la Ciencia del Suelo

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, T.; Chabrillat, S.; Guerrero, C.; Jimenez, M.; Lopez, F.; Palacios, A.; Pelayo, M.; Rodriguez, M.

    2012-07-01

    This work is the result of an internal course that was held in CIEMAT under the framework of activities within the ''Itinerario Formativo: Tecnicas experimentales de apoyo a la Investigacion I+D+I'', as part of the Programa de Acciones Conjuntas de OPIs (CIEMAT, INTA and IGME) financed by the Instituto Nacional de Administracion Publica (INAP). The course was aimed at researchers, technical staff and students associated to the different OPIs introducing them to spectroradiometric techniques for determining soil properties and processes and obtain a thorough insight into the compilation and applications of spectral libraries. This course was directed and organized by CIEMAT with experts specialized in the field of spectro radiometry presenting the corresponding theory and application as well as practical work carried out in the laboratory and in the field. The course is within the research lines carried out by the group Unidad de Conservacion y Recuperacion de Suelos of the Departamento de Medio Ambiente in CIEMAT. (Author)

  7. Development and implementation of an EPICS-based accelerator control interface and automated beam optimisation at the S-DALINAC; Entwicklung und Implementierung einer EPICS-basierten Beschleuniger-Steuerungsschnittstelle und automatisierten Strahloptimierung am S-DALINAC

    Energy Technology Data Exchange (ETDEWEB)

    Schoesser, Thomas

    2017-06-12

    This thesis is divided into two parts of improvements to the accelerator control system of the S-DALINAC. In the first part the finalisation of the EPICS migration to the S-DALINAC control system is presented. Therefore the input-outputcontrollers(IOCs) of the controls of magnets, the targets, and the video multiplexer are included into the EPICS framework. In addition to that the operator interfaces(OPIs) of the controls of magnets and targets are implemented. To configure these IOCs and OPIs a relational database is used, which was extended within this thesis. In- and output of magnet control is provided by rotating knobs and touch screens, which hardware were modernised. The realised steps are doing their part in reducing perturbations and ease up operations since. The second part covers the automated optimisation of beam optics. Therefore the software AreaDetector was integrated into the S-DALINAC control system. The functionality is shown by the example of setting a quadrupol magnet deflection-free fully automated. Also the flexibility enables other setups to be automatically optimised in the future.

  8. SNS online display technologies for EPICS

    International Nuclear Information System (INIS)

    Kasemir, K.U.; Chen, X.; Purcell, J.; Danilova, E.

    2012-01-01

    The ubiquitousness of web clients from personal computers to cell phones results in a growing demand for web-based access to control system data. At the Oak Ridge National Laboratory Spallation Neutron Source (SNS) we have investigated different technical approaches to provide read access to data in the Experimental Physics and Industrial Control System (EPICS) for a wide variety of web client devices. The core web technology, HTTP, is less than ideal for online control system displays. Appropriate use of Ajax, especially the Long Poll paradigm, can alleviate fundamental HTTP limitations. The SNS Status web uses basic Ajax technology to generate generic displays for a wide audience. The Dashboard uses Long Poll and more client-side Java-Script to offer more customization and faster updates for users that need specialized displays. The Web OPI uses RAP for web access to any BOY display, offering utmost flexibility because users can create their own BOY displays in CSS. These three approaches complement each other. Users can access generic status displays with zero effort, invest time in creating their fully customized displays for the Web OPI, or use the Dashboard as an intermediate solution

  9. Phosphatidylcholine Supply to Peroxisomes of the Yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Flis, Vid V; Fankl, Ariane; Ramprecht, Claudia; Zellnig, Günther; Leitner, Erich; Hermetter, Albin; Daum, Günther

    2015-01-01

    In the yeast Saccharomyces cerevisiae, phosphatidylcholine (PC), the major phospholipid (PL) of all organelle membranes, is synthesized via two different pathways. Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. To determine the contribution of these two pathways to the supply of PC to peroxisomes (PX), yeast mutants bearing defects in the two pathways were cultivated under peroxisome inducing conditions, i.e. in the presence of oleic acid, and subjected to biochemical and cell biological analyses. Phenotype studies revealed compromised growth of both the cho20Δopi3Δ (mutations in the methylation pathway) and the cki1Δdpl1Δeki1Δ (mutations in the CDP-choline pathway) mutant when grown on oleic acid. Analysis of peroxisomes from the two mutant strains showed that both pathways produce PC for the supply to peroxisomes, although the CDP-choline pathway seemed to contribute with higher efficiency than the methylation pathway. Changes in the peroxisomal lipid pattern of mutants caused by defects in the PC biosynthetic pathways resulted in changes of membrane properties as shown by anisotropy measurements with fluorescent probes. In summary, our data define the origin of peroxisomal PC and demonstrate the importance of PC for peroxisome membrane formation and integrity.

  10. Protecting the ocular surface and improving the quality of life of dry eye patients: a study of the efficacy of an HP-guar containing ocular lubricant in a population of dry eye patients.

    Science.gov (United States)

    Rolando, Maurizio; Autori, Silvia; Badino, Francesco; Barabino, Stefano

    2009-06-01

    The aim of this study was to evaluate the efficacy of a non-Newtonian tear substitute containing 0.4% polyethylene glycol 400 (PEG 400) and 0.3% propylene glycol in an 0.18% hydroxypropyl-guar (HPG) containing vehicle (Systane Lubricant Eye Drops; Alcon) in reducing the signs and symptoms of dry eye, as well as its effect on ocular protection. Twenty patients with moderate to severe dry eye were enrolled in a 28-day prospective, randomized, controlled study. Subjects self-administered the HPG containing ocular lubricant four times daily (QID) over the study duration. After 28 days, the effect of the HPG containing ocular lubricant was evaluated by means of the Global Staining Score (a measure of the corneal and conjunctival staining), inter-blink tear film stability, Ocular Protection Index (OPI), and subjective symptoms. The HPG containing ocular lubricant produced statistically significant improvements compared with baseline in dry eye symptoms (P eye symptoms with the HPG containing ocular lubricant -- evident as early as the first follow-up visit (Day 7) and continued throughout the 28 days of the study with a concurrent, increase in OPI to a level greater than unity -- indicate that this preparation is a fast-acting, long-lasting, and effective treatment for dry eye. In concurrence with the results from previously published clinical studies, the HPG containing ocular lubricant has shown efficacy in alleviating the signs and symptoms of dry eye as well as affording improved ocular surface protection.

  11. Results from transient transport experiments in Rijnhuizen tokamak project: Heat convection, transport barriers and 'non-local' effects

    International Nuclear Information System (INIS)

    Mantica, P.; Gorini, G.; Hogeweij, G.M.D.; Kloe, J. de; Lopez Cardozo, N.J.; Schilham, A.M.R.

    2001-01-01

    An overview of experimental transport studies performed on the Rijnhuizen Tokamak Project (RTP) using transient transport techniques in both Ohmic and ECH dominated plasmas is presented. Modulated Electron Cyclotron Heating (ECH) and oblique pellet injection (OPI) have been used to induce electron temperature (T e ) perturbations at different radial locations. These were used to probe the electron transport barriers observed near low order rational magnetic surfaces in ECH dominated steady-state RTP plasmas. Layers of inward electron heat convection in off-axis ECH plasmas were detected with modulated ECH. This suggests that RTP electron transport barriers consist of heat pinch layers rather than layers of low thermal diffusivity. In a different set of experiments, OPI triggered a transient rise of the core T e due to an increase of the T e gradient in the 1< q<2 region. These transient transport barriers were probed with modulated ECH and found to be due to a transient drop of the electron heat diffusivity, except for off-axis ECH plasmas, where a transient inward pinch is also observed. Transient transport studies in RTP could not solve this puzzling interplay between heat diffusion and convection in determining an electron transport barrier. They nevertheless provided challenging experimental evidence both for theoretical modelling and for future experiments. (author)

  12. Development of EPICS based beam-line experimental control employing motor controller for precision positioning

    International Nuclear Information System (INIS)

    Tuli, Anupriya; Jain, Rajiv; Vora, H.S.

    2015-01-01

    In a Synchrotron Radiation Source the beamline experiments are carried out in radiation prone environment, inside the hutch, which demands to conduct experiments remotely. These experiments involves instrument control and data acquisition from various devices. Another factor which attributes to system complexity is precise positioning of sample and placement of detectors. A large number of stepper motors are engaged for achieving the required precision positioning. This work is a result of development of Experimental Physics and Industrial Control System (EPICS) based control system to interface a stepper motor controller developed indigenously by Laser Electronics Support Division of RRCAT. EPICS is an internationally accepted open source software environment which follows toolkit approach and standard model paradigm. The operator interface for the control system software was implemented using CSS BOY. The system was successfully tested for Ethernet based remote access. The developed control software comprises of an OPI and alarm handler (EPICS ALH). Both OPI and ALH are linked with PV's defined in database files. The development process resulted into a set of EPICS based commands for controlling stepper motor. These commands are independent of operator interface, i.e. stepper motor can be controlled by using these set of commands directly on EPICS prompt. This command set is illustrated in the above table. EPICS Alarm Handler was also tested independently by running these commands on EPIC prompt. If not using ALH, operator can read the alarm status of a PV using 'SEVR' and 'STAT' attributes. (author)

  13. Thermodynamic Description Of Ternary Fe-B-X Systems. Part 2: Fe-B-Ni

    Directory of Open Access Journals (Sweden)

    Miettinen J.

    2014-06-01

    Full Text Available Przedstawiono termodynamiczny opis trójskładnikowego układu Fe-B-Ni w kontekście nowej bazy danych dla układów Fe-B-X (X = Cr, Ni, Mn, Si, Ti, V, C. Parametry termodynamiczne dwuskładnikowych stopów Fe-B. Fe-Ni i B-Ni zostały są zaczerpnięte z wcześniejszych opracowań, przy tym opis B-Ni został nieznacznie zmodyfikowany. Parametry dla układu Fe-B-Ni zostały zoptymalizowane w tej pracy w oparciu o eksperymentalne równowagi fazowe i dane termodynamiczne zaczerpnięte z literatury. Roztwory stałe w układzie Fe-B-Ni opisano przy użyciu modelu roztworu substytucyjnego, a borki traktowane są jako fazy stechiometryczne lub półstechiometryczne typu (A.BpCq opisane przy użyciu modelu dwu podsieci.

  14. 'Non-local' response of RTP ohmic plasmas to peripheral perturbations

    International Nuclear Information System (INIS)

    Galli, P.; Gorini, G.; Mantica, P.; Hogeweij, G.M.D.; Kloe, J. de; Lopes Cardozo, N.J.

    1999-01-01

    A 'non-local' response of the plasma core triggered by peripheral plasma perturbations other than laser ablation is found in the RTP tokamak. Oblique pellet injection (OPI) has been used to induce fast cooling of the peripheral plasma. In response, an inward cold pulse (T e drop) and a slightly delayed core T e rise are observed. A somewhat similar 'non-local' response is observed when the peripheral plasma is heated by modulated electron cyclotron heating or by fast current ramps, i.e. the core temperature drops in response to the peripheral heating. The plasma conditions for the occurrence of the 'non-local' response have been investigated. The core T e rise following OPI is associated with the formation of a large temperature gradient in the region 1 e rise is largest at low electron density and for large pellet deposition radii. Above a critical density the T e rise disappears and only the (weaker) drop in core T e is observed. Time dependent transport simulations show that the propagation of the inward cold pulse is consistent with local transport, while the core T e rise is a slower phenomenon requiring a large transient drop of χ e in the region 1 < q < 2. (author)

  15. Avaliação da buprenorfina pelas vias intravenosa ou intramuscular em cães anestesiados pelo desfluorano

    Directory of Open Access Journals (Sweden)

    Souza Almir Pereira de

    2004-01-01

    Full Text Available Objetivou-se avaliar comparativamente os efeitos da buprenorfina, administrada pelas vias intramuscular(IM ou intravenosa (IV, sobre variáveis cardiovasculares, em cães anestesiados com desfluorano. Para tanto, foram utilizados dezesseis cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=8 denominados de GI e GII. Em ambos os grupos, a anestesia foi induzida com propofol (8 mg/kg, IV e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desfluorano (1,5 CAM. Após 30 minutos do início da anestesia inalatória, foi aplicado no GI buprenorfina na dose de 0,02 mg/kg pela via IV, enquanto no GII administrou-se o opióide na mesma dose porém pela via IM. Avaliaram-se: freqüência cardíaca (FC; pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM; débito cardíaco (DC; pressão venosa central (PVC e pressão da artéria pulmonar (PAP. As colheitas foram feitas nos seguintes momentos: M1 - 30 minutos após o início da anestesia inalatória antes da aplicação do opióide; M2 - 15 minutos após a administração da buprenorfina; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (p<0,05. As variáveis PAS, PAM, DC, PVC e PAP, não apresentaram alterações significativas de seus valores em ambos os grupos. Entretanto, a FC e a PAD apresentaram reduções significativas após a administração do opióide apenas no GI. Assim, pôde-se concluir que a buprenorfina administrada pelas vias IV ou IM não interferiu nos índices cardiovasculares de forma a manifestar efeitos clínicos importantes em cães anestesiados com desfluorano.

  16. Ocular iontophoresis of EGP-437 (dexamethasone phosphate in dry eye patients: results of a randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Patane MA

    2011-05-01

    Full Text Available Michael A Patane¹, Amy Cohen¹, Stephen From¹, Gail Torkildsen², Donna Welch³, George W Ousler III³¹Eyegate Pharmaceuticals, Inc, Waltham, MA, USA; ²Andover Eye Associates, Andover, MA, USA; ³Ora, Inc, Andover, MA, USAPurpose: To assess safety and efficacy of EGP-437 (dexamethasone phosphate 40 mg/mL [DP] in dry eye patients.Methods: The study employed a prospective, single-center, double-masked design utilizing a Controlled Adverse Environment (CAE. Patients (n = 103 with confirmed signs and symptoms of dry eye syndrome were randomized into 1 of 3 iontophoresis treatment groups: 7.5 mA-min at 2.5 mA (DP 7.5, n = 41; 10.5 mA-min at 3.5 mA (DP 10.5, n = 37; or 10.5 mA-min at 3.5 mA (placebo, n = 25. Three CAE visits and 4 follow-up visits occurred over 3 weeks. Patients meeting enrollment criteria received iontophoresis in both eyes after the second CAE exposure (visit 3 and before the third CAE exposure (visit 5. Primary efficacy endpoints were corneal staining and ocular discomfort. Secondary endpoints included tear film break-up time, ocular protection index (OPI, and symptomatology.Results: The DP 7.5 and DP 10.5 treatment groups showed statistically significant improvements in signs and symptoms of dry eye at various time points; however, the primary endpoints were not achieved. The DP 7.5 treatment group exhibited statistically significant improvements in corneal staining (when comparing the differences between study entry and exit, 3 weeks, P = 0.039, OPI (immediately following the second treatment, P = 0.048 and ocular discomfort at follow-up visits (a week after the first treatment, P = 0.032; 24 hours after the second treatment, P = 0.0032. Treatment-emergent adverse events (AEs were experienced by 87% of patients and were consistent across all treatment groups. Most AEs were mild and no severe AEs were observed.Conclusion: Ocular iontophoresis of EGP-437 demonstrated statistically and clinically significant improvements in

  17. Dor oncológica

    Directory of Open Access Journals (Sweden)

    Carla Alves Costa

    2007-11-01

    Full Text Available Resumo: A dor pode ser definida de várias formas, sendo habitualmente descrita como uma experiência sensorial e emocional desagradável associada a lesão tecidular real ou potencial, ou descrita em função de tal lesão. No doente oncológico, a dor pode estar relacionada com a neoplasia, com o seu tratamento, ou não ter relação com a doença neoplásica. A dor tem grande impacto no doente oncológico, significando agravamento do prognóstico ou morte próxima, daí a importância de uma abordagem e tratamento correctos. As opções para o tratamento farmacológico são várias, estando disponíveis analgésicos não opióides, opióides e co-analgésicos. Os autores pretendem com este artigo rever o tratamento farmacológico da dor e alertar para a importância do reconhecimento da dor como doença e da possibilidade de tratar e aliviar os doentes.Rev Port Pneumol 2007; XIII (6: 855-867 Abstract: Pain can be defined by several ways, but is usually describes as an unpleasant sensorial or emotional experience related to real or potential tissue damage, or described in terms of such damage. The cancer patient may experience pain related to the cancer itself, its treatment or not related at all with the oncologic disease. It has an extreme importance to the patient, as it is interpreted as a worsening of the prognosis or near death. Therefore it is extremely important a correct approach and treatment of cancer pain. Pain can be treated by pharmacologic, non-pharmacologic means and by more invasive procedures. The options for pharmacologic treatment are various, since nonopioid, opioid analgesics and co-analgesics. The authors present a review of the pharmacological treatment of cancer pain and alert to the importance of the recognition of pain as an illness and the possibility to be relieved.Rev Port Pneumol 2007; XIII (6: 855-867 Palavras-chave: Dor, dor oncológica, analgésicos, opióides, Key-words: Pain, cancer pain, analgesics, opioids

  18. Dor oncológica

    Directory of Open Access Journals (Sweden)

    Carla Alves Costa

    2007-11-01

    Full Text Available Resumo: A dor pode ser definida de várias formas, sendo habitualmente descrita como uma experiência sensorial e emocional desagradável associada a lesão tecidular real ou potencial, ou descrita em função de tal lesão. No doente oncológico, a dor pode estar relacionada com a neoplasia, com o seu tratamento, ou não ter relação com a doença neoplásica. A dor tem grande impacto no doente oncológico, significando agravamento do prognóstico ou morte próxima, daí a importância de uma abordagem e tratamento correctos. As opções para o tratamento farmacológico são várias, estando disponíveis analgésicos não opióides, opióides e co-analgésicos. Os autores pretendem com este artigo rever o tratamento farmacológico da dor e alertar para a importância do reconhecimento da dor como doença e da possibilidade de tratar e aliviar os doentes. Abstract: Pain can be defined by several ways, but is usually describes as an unpleasant sensorial or emotional experience related to real or potential tissue damage, or described in terms of such damage. The cancer patient may experience pain related to the cancer itself, its treatment or not related at all with the oncologic disease. It has an extreme importance to the patient, as it is interpreted as a worsening of the prognosis or near death. Therefore it is extremely important a correct approach and treatment of cancer pain. Pain can be treated by pharmacologic, non-pharmacologic means and by more invasive procedures. The options for pharmacologic treatment are various, since nonopioid, opioid analgesics and co-analgesics. The authors present a review of the pharmacological treatment of cancer pain and alert to the importance of the recognition of pain as an illness and the possibility to be relieved. Palavras-chave: Dor, dor oncológica, analgésicos, opióides, Key-words: Pain, cancer pain, analgesics, opioids

  19. Elicitation of dopaminergic features of Parkinson's disease in C. elegans by monocrotophos, an organophosphorous insecticide.

    Science.gov (United States)

    Ali, Shaheen Jafri; Rajini, Padmanabhan Sharda

    2012-12-01

    Positive correlations have been suggested between usage of pesticides and the incidence of Parkinson's disease (PD) through epidemiological as well as few experimental evidences. Organophosphorus insecticides (OPI), which are extensively used in agricultural and household insect control, have been the subject of increasing concern in the past decades due to their neurotoxic potential. However, very few studies have demonstrated the potentials of OPI to induce features of PD in model organisms. In the present study, Caenorhabditis elegans was selected as the model organism to evaluate the potential of monocrotophos (MCP), an OPI, to elicit dopaminergic features of Parkinson's disease in terms of dopamine content, basic movement and integrity of dopaminergic neurons along with its effect on acetylcholinesterase (AChE) activity and life span. All the responses elicited by MCP were compared with that elicited by 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridine (MPTP) in both N2 and BZ555 worms. N2 worms were exposed to varying concentrations of MCP (50, 100 and 200 μM) or MPTP (200, 300 and 400 μM) for 48 hours and locomotory rate, as measured by the number of body bends made in 20 seconds, was enumerated. Worms subjected to the same dose paradigms were also analyzed for the dopamine content by HPLC. The results indicated a significant reduction in the dopamine levels in the worms that were treated with MCP/MPTP and this correlated with the changes in locomotion compared to untreated worms. Worms treated with MCP also exhibited significant reduction in AChE activity. Both MPTP and MCP caused a marked reduction in life span in the worms. Transgenic worms (BZ555, which has GFP tagged to its 8 dopaminergic neurons) exposed to MCP and MPTP at the above concentrations showed a dose-dependent reduction in the number of green pixels in CEP and ADE neurons which also correlated with the neurodegeneration as visualized by decreased fluorescence in photomicrographs. Taken

  20. RB research nuclear reactor - Annual report for 1986, I - III; Istrazivacki nuklearni reaktor RB (Izvestaj o radu u 1986. godini), I-III

    Energy Technology Data Exchange (ETDEWEB)

    Markovic, H; Pesic, M; Vranic, S; Petronijevic, M; Jevremovic, M; Ilic, I [Boris Kidric Institute of Nuclear Sciences Vinca, Beograd (Yugoslavia)

    1987-07-01

    This report includes data concerning the RB reactor operation in 1986, state of the reactor components, data about the employed personnel and the database of experimental and other reactor related devices. It is made of 3 parts: Engineering description and operation of the RB reactor including dosimetry, reactor staff data and financial report; Reactor facility components and maintenance; RB reactor operation and utilization in 1986. Izvestaj pokazuje podatke o radu reaktora RB u toku 1986. godine, stanje reaktorske opreme, podatke o angazovanom osoblju na reaktoru i datoteku sa podacima o eksperimentalnoj i drugoj opremi reaktora RB. Sastoji se od 3 dela: tehnicki opis, pogon i rad reaktora, oprema postrojenja i njeno odrzavanje, koriscenje reaktora u 1986. godini.

  1. Incidência de infecção em pacientes com cateter peridural tunelizado Incidencia de infección en pacientes con cateter peridural tunelizado Infection incidence in patients with tunneled peridural catheter

    Directory of Open Access Journals (Sweden)

    Maria Cecilia Iksilara

    2005-04-01

    Full Text Available O cateter peridural tunelizado como via de administração de opiáceos vem sendo utilizado desde o início de 1980. Pacientes com dor crônica, que não obtêm alívio com medicamentos por outras vias, são muito beneficiados com infusão de opiáceo associado a um anestésico local por via peridural. Entretanto, ainda existem dúvidas sobre a eficácia do método, no manuseio e, conseqüentemente, quanto ao risco de infecção e outras complicações. Sendo a equipe de enfermagem fundamental para efetivar o tratamento para o alívio da dor, esse estudo propõe demonstrar como manter a técnica segura. Foram acompanhados 27 pacientes com dor crônica entre 2002 e 2004, que utilizaram o cateter peridural por 18 dias em média, implantados em nível torácico ou lombar. Não houve complicações como abcesso peridural, meningite ou hematoma peridural. A satisfação dos pacientes quanto a analgesia foi evidente.El cateter peridural tunelizado, como via de administración de opióides, es utilizado desde el comienzo de 1980. Pacientes con dolor crónico, que no tienen alivio con medicamentos por otras vias, son muy beneficiados con la administración de opióides, asociados a un anestésico local por via peridural. Sin embargo, aún existen dudas sobre la eficacia del método, en el manejo y, como consecuencia, en el riesgo de infección y otras complicaciones. Siendo el equipo de enfermería fundamental para ejecutar el tratamiento para alivio del dolor, esto estudio se propone a presentar como mantener la técnica segura. Vinte y siete pacientes con dolor crónica, entre 2002 a 2004, que utilizarón el cateter peridural por 18 dias en media, fuerón seguidos. Los cateteres fuerón implantados al nivele toracico o lumbar. No se presentaran complicaciones como absceso peridural, meningitis o hematoma peridural. La satisfacción de los pacientes quanto analgesia fué evidente.The tunneled epidural catheter as an administration access for opiates

  2. WYKORZYSTANIE METODY DAVE’A BERKUSA DO ANALIZY POTENCJAŁU ROZWOJOWEGO FIRM START-UP W POLSCE

    OpenAIRE

    Gemzik-Salwach, Agata

    2014-01-01

    Celem niniejszego artykułu była ocena potencjału rozwojowego firm start-up w Polsce. W artykule przedstawione zostały metody oceny przedsiębiorstw start-up oraz wyniki badań własnych poświęconych potencjałowi firm start-up w Polsce. Pierwszą część artykułu stanowi opis cech charakterystycznych młodych spółek i możliwych sposobów ich wyceny. Kolejna cześć artykułu obejmuje szczegółowe omówienie wyników przeprowadzonych badań. W badaniach wykorzystano powstałą na bazie doświadczeń amerykańskieg...

  3. The new control system of HLS linac and transport line

    International Nuclear Information System (INIS)

    Liu Gongfa; Li Weimin; Li Jingyi; Li Chuan; Cheng Liping; Bao Xun; Wang Jigang; Xuan Ke

    2005-01-01

    The new linac and transport line control system of Hefei Light Source (HLS) is a distributed control system based on EPICS (Experimental Physics and Industrial Control System). Industrial PC (IPC) is widely used as not only Input/Output Controller (IOC) but also device controller. Besides industrial PC, PLC and microcontroller are also used as device controllers. The software for industrial PC based device controller is developed based on VxWorks real-time operating system. The software for PLC and microcontroller are written with ladder software package and assemble language, respectively. PC with Linux and SUN workstation with Solaris are used as operator interfaces (OPI). High level control is made up of some EPICS tools and Tcl/Tk scripts. (authors)

  4. Elicited Imitation for Brazilian Portuguese

    Directory of Open Access Journals (Sweden)

    Lonsdale, Deryle W.

    2015-01-01

    Full Text Available Elicited imitation (EI is an approach to measuring oral proficiency that consists of having test takers hear a sentence and repeat the sentence exactly as they heard it. Though indirect in nature, EI has successfully shown to correlate with previously established oral proficiency examinations, such as the Oral Proficiency Interview (OPI (Lonsdale and Christensen 2014, Matsushita and Lonsdale 2014, Millard 2011, Thompson 2013. This paper discusses the development, administration, and evaluation of an EI test for the Brazilian Portuguese language. We first discuss the relevant background of oral proficiency examination and EI. After presenting the pertinent research questions, we explain the methodology used to develop the EI test, recruit participants, and administer the test. We present the results and analysis and then summarize the findings, limitations, and possible future work

  5. Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 1 for Pease Air Force Base, New Hampshire. Volume 2. Appendices.

    Science.gov (United States)

    1987-08-01

    san Agency Judgment on an amn pces that are more sensitive The .vlaldt’a . acca ~ble" siskieavel. . that those tested. Mortality to early life...METHOD -30 c 7P~4- 1]I07- .ps cC4 Zw /5(,ov 12򒵃 /I04dOSIT/ - RIEP PIIS Bi,0614 L 1 111 16" AL F6 t 7 9 2349, -* ,* I- ~CL */1.CIIIT C-CL).1- LI tNT I...LWpCL MAILSE ORIGINALD (.. .I hla REPRT 7e__ _ __ _ __ _ 1" -L 5.um.Iwf TOr4 c0opy 131210421, ( ^i F6 .,Ol+,3uicj.Imb3 COPYS 2L0 _______COLLCTEDB_____

  6. Postirradiation examination report of TRISO and BISO coated ThO2 particles irradiated in capsules HT-31 and HT-33

    International Nuclear Information System (INIS)

    Sedlak, B.J.

    1980-01-01

    Capsules HT-31 and HT-33 were uninstrumented capsule experiments irradiated in the target position of the High-Flux Isotope Reactor at Oak Ridge National Laboratory. The experiments were used to evaluate the irradiation performance of (1) fuel fabricated in a 240-mm-diameter coater for production scale-up, (2) TRISO ThO 2 and BISO ThO 2 particles, and (3) fuel with certain OPyC variables. A total of 16 BISO particle samples and 32 TRISO particle samples were irradiated to fast neutron fluences ranging from 4.0 to 11.7 x 10 25 n/m 2 (E > 29 fJ)/sub HTGR/ and heavy metal burnups between 3.5% and 13.2% FIMA at temperatures from 1150 0 to 1530 0 C

  7. The spaces of the margin. History of Sexuality and LGBTIQ studies from an interdisciplinary perspective

    Directory of Open Access Journals (Sweden)

    Elisabetta Bini

    2013-10-01

    Full Text Available The essay offers an overview of LGBTIQ studies, by analyzing several texts that have influenced the debate and research about the history of sexuality and LGBTIQ identities. The first part examines the forms of exchange and contamination between LGBTIQ and historical studies. The author argues that, since they emerged in the 1970s, LGBTIQ studies have aimed at challenging the specific forms of discrimination carried out against gays and lesbians, by highlighting the historical and social construction of sexuality and sexual identities. The essay focuses in particular on the importance of works by Michel Foucault, Adrienne Rich, Monique Wittig, Judith Butler, Teresa de Lauretis and American “women of color,” and their influence on historical research. The second part of the essay examines the photographs taken by several artists whose work focuses on sexual identities, such as Claude Cahun, Nan Goldin, Catherine Opie and Del LaGrace Volcano.

  8. factores psicosociales asociados

    Directory of Open Access Journals (Sweden)

    María Teresa Varela Arévalo

    2007-01-01

    Full Text Available El objetivo de este trabajo fue describir el consumo de sustancias psicoactivas [SPA] ilegales en jóvenes y los factores psicosociales de riesgo y de protección asociados. Participaron 763 estudiantes (46,5% hombres y 52,4% mujeres de una universidad privada de Cali, quienes diligenciaron el cuestionario de factores de riesgo y protección para el consumo de drogas. Los resultados muestran que la marihuana fue la droga de mayor consumo; y que existe una fuerte asociación entre el consumo de las cuatro SPA ilegales (marihuana, opiáceos, cocaína y éxtasis y los factores psicosociales de riesgo y/o protección, principalmente, las habilidades de autocontrol, los preconceptos y valoración de las SPA, la relación con personas consumidoras y los comportamientos perturbadores.

  9. Optimalizace experimentálních parametrů v sestavě dvoupulzní LIBS

    OpenAIRE

    Roščák, Michal

    2010-01-01

    V diplomovej práci je opísaná metóda spektroskopie laserom indukovanej plazmy (LIBS) ako aj možnosť zníženia detekčných limitov použitím metódy dvojpulznej LIBS (DP-LIBS). Práca taktiež pojednáva o vlastnostiach laserom indukovanej plazmy (LIP). Obsahuje opis DP-LIBS aparatúry laboratória laserovej spektroskopie Fakulty strojního inženýrství, Vysoké učení technické v Brně, ako aj postup optimalizácie jej parametrov. Optimalizácia bola vykonaná pre detekciu chrómu v oceli s ohľadom na detekčné...

  10. The Cost Growth Problem: A Realistic Diagnosis and Solution.

    Science.gov (United States)

    1983-06-01

    access 30 0~ LJ 0 CD 0 ( 4c CD - V2 0 C.2 ~~CD.------ 0.0 4-J V) 0 0.0 C.,I Cdc = CC, 0 0D C2 =I . 31 haua La OC I- c C _g .- C2 n C2 __. 6.34 LIA ca D...Department Navy Military Personnel Command Washington, D.C. 20370 6. Director for HRM Plans and Policy (OP-IS0) 1 Human Resource Management Division...Washington, D.C. 20301 25. Dana French, CAPT, USN HD HRM Plans & Policy Branch Washington, D.C. 20301 26. Robert Aaron 820 Lamberton Drive Silver

  11. OGLAŠEVANJE IN MANIPULACIJA: ŠTUDIJA PRIMERA

    OpenAIRE

    Lazar, Alja

    2015-01-01

    Diplomska naloga se začne z definicijo oglaševanja. Na splošno povemo kaj je, opišemo zgodovino ter načine oglaševanja. Ker pa oglaševanje pogosto vsebuje manipulativni način, smo se osredotočili še na manipulacijo. Povedali kaj je, kakšne so njene pojavne oblike in kako vpliva na ljudi. Osredotočimo se na manipulacijo, kot ključni element oglaševanja, ugotavljamo razsežnost manipuliranja, ter kako manipulativno oglaševanje deluje na ljudi. Manipulativno oglaševanje moralno ovrednotimo, ter ...

  12. Irradiation tasks within development of fuel elements in Sweden; Rad na ozracivanju u okviru razvoja gorivnih elemenata u Svedskoj

    Energy Technology Data Exchange (ETDEWEB)

    Stevanovic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Yugoslavia)

    1966-11-15

    This report contains description of the hot laboratory RMA for irradiation in the R-2 reactor in Studsvik. Activities of the AB Atomenegiyu concerning irradiation and testing of fuel rods and fuel elements are described, as well as methods for testing of irradiated samples in hot cells. Concerning the importance of the problem, determination of burnup level and neutron flux were examined particularly. Dat je opis vruce metalurske laboratorije RMA i sistema za ozracivanje u reaktoru R-2 u Studsviku. Prikazana je aktivnost AB Atomenergy u okviru razvoja gorivnih elemenata na ozracivanju i ispitivanju ozracenog goriva, gorivnih sipki i sklopova gorivnih elemenata. Prikazane su metode ispitivanja ozracenih uzoraka u vrucim celijama. S obzirom na vaznost problema, posebno je razradjeno pitanje odredjivanja stepena izgaranja i fluksa neutrona (author)

  13. Tv-mainonnan kehitys leikkaajan näkökulmasta

    OpenAIRE

    Kontunen, Piia

    2015-01-01

    Tämä opinnäytetyö kertoo tv-mainonnan muutoksista sekä kehityksestä koko niiden olemassaolon ajalta. Millaista on tv-mainonta nykyään ja kuinka tv-mainoksien keskeiset elementit ovat muuttuneet? Opinnäytetyö lähestyy aihetta leikkaajan näkökulmasta ja tutkii asioita joihin leikkaaja työssään kiinnittää huomiota. Television tulevaisuudesta on keskusteltu jo pitkään. Mikä on tv-mainosten mahdollinen tulevaisuus. Voiko sitä ennustaa tuntemalla historian vai onko vihjeitä jo löydettävissä? Opi...

  14. Model improwizacji polifonicznej na tle popularnych metod improwizacji w muzyce rozrywkowej

    Directory of Open Access Journals (Sweden)

    Adam Fulara

    2012-12-01

    Full Text Available Artykuł składa się z dwóch części. Pierwsza z nich, bardziej ogólna, zawiera opis zjawisk związanych z improwizacją, zwłaszcza gitarową, z wyszczególnieniem problemów wykonawczych stojących przed improwizatorem. Dwa punkty widzenia zostały przedstawione: pierwszy, szczegółowy, opisuje po kolei elementy muzyki i ich znaczenie w procesie improwizacji, drugi bardziej ogólny mówi o zjawiskach, których nie da się opisać, ani analizować w prosty sposób, bądź są inne w przypadku każdego utworu. Należy do nich interakcja pomiędzy członkami zespołu, wyrażanie emocji poprzez muzykę i problematykę poszukiwań własnego głosu w sztuce. Ta część zawiera jeszcze opis trzech zupełnie różnych podejść do improwizacji na gitarze. Pierwsza to wykorzystanie centrum tonalnego (wzbogaconego napięciami dominantowymi, druga metoda polega na połączeniu harmonii utworu ze stosowanymi skalami (stosowana w muzyce fusion, trzecia polega na ścisłym wykorzystaniu dźwięków akordowych w improwizacji bez stosowania skal (charakterystyczna dla muzyki bebop. Druga część tekstu zawiera opis szczególnego rodzaju improwizacji polifonicznej z wykorzystaniem tappingu oburęcznego na gitarze. Model ten stoi w opozycji do trzech wcześniej przedstawionych sposobów rozumienia improwizacji gitarowej. System opiera się zarówno na metodach stosowanych w polifonii renesansu i baroku (m. in. melodia wiodąca Cantus Firmus, reguły kontrapunktu, jak i na założeniach jednogłosowej improwizacji bebopowej (wykorzystanie dźwięków wiodących, rozwiązania charakterystyczne dla czterodźwięków naturalnych. Opis ten nawiązuje do pierwszej części artykułu, grupując zagadnienia wokół poszczególnych elementów dzieła muzycznego. Ta część zawiera uwagi i spostrzeżenia zebrane w ciągu ośmiu lat poszukiwań własnej drogi muzycznej autora.

  15. Estudo da atividade do látex do Croton urucurana Baill. sobre o trânsito gastrintestinal de camundongos

    Directory of Open Access Journals (Sweden)

    Luilma Albuquerque Gurgel

    Full Text Available O presente trabalho tem como propósito avaliar uma possível atividade inibitória do látex do Croton urucurana Baill. sobre o trânsito gastrintestinal de camundongos, bem como tentar esclarecer os possíveis mecanismos de ação envolvidos em sua atividade. Foram utilizados os modelos de trânsito gastrintestinal normal e trânsito gastrintestinal estimulado por fisostigmina em camundongos. Os resultados obtidos mostram que o látex inibiu o trânsito gastrintestinal de camundongos, e, muito embora seu mecanismo de ação ainda não seja claro, seu efeito é independente da participação de mecanismo opióide, colinérgico, α2-adrenérgico ou nitriérgico.

  16. Safety analysis for testing operation of the RA reactor in the Boris Kidric Institute, Vinca; Analiza sigurnosti rada reaktora 'RA' za probni rad u Institutu za nuklearne nauke 'Boris Kidric' - Vinca

    Energy Technology Data Exchange (ETDEWEB)

    Milosevic, M et al. [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1980-09-15

    This safety report covers detailed description of the RA reactor core, reactor components, coolant system, control system, safety system, reactor building including site characteristics. A separate chapter is devoted to radiation protection and radioactive waste management. Organizational structure od the reactor staff as well as training program are included. The last chapter includes detailed emergency plans for three accidents classified in three categories. [Serbo-Croat] Ovaj izvestaj sadrzi detaljan opis reaktora RA, sistema za hladjenje, kontolno-sigurnosnog sistema, elektricnog sistema, zgrade sa instalacijama, ukljucujuci karakteristike lokacije. Posebno poglavlje opisuje sistem zastite od zracenja i rukovanje radioaktivnim otpadom. Opisana je organizacija rada i program obuke osoblja. Poslednje poglavlje sadrzi detaljan plan mera za slucaj udesa klasifikovanih u tri kategorije.

  17. Estudio sobre modelo de oficinas de transferencia tecnológica en el Perú

    OpenAIRE

    Ísmodes, Eduardo

    2015-01-01

    El presente documento es el resultado de una investigación, análisis y evaluación del desarrollo y la evolución de las Oficinas de Transferencia de Tecnología (OTT) en diversos países del mundo occidental y de América Latina. El estudio incorpora una investigación sobre la situación de las unidades de Transferencia de Tecnología en varias Instituciones de Educación Superior (IES) y Organismos Públicos de Investigación (OPIs) en el Perú y finaliza con una propuesta que permita implementar de m...

  18. The New Edition of Chopin’s Correspondence

    Directory of Open Access Journals (Sweden)

    Helman-Bednarczyk Zofia

    2016-12-01

    Full Text Available Some of Fryderyk Chopin’s letters were published individually or in groups already in the 2nd half of the 19th century. With the passage of time, more letters from and to Chopin were printed in monographs dedicated to his life and work. The first editions of Chopin’s collected letters come from the 1st half of the 20th century (by Scharlitt and von Guttry in Germany, Henryk Opieński – in Poland. B.E. Sydow’s Fryderyk Chopin’s Correspondence of 1955 continues to be used as the basic source edition by Chopin biographers. It has many strong points, but has become largely outdated.

  19. Independent CO{sub 2} loop for cooling the samples irradiated in vertical experimental channels of the RA reactor, Vol. I; Nezavisno kolo CO{sub 2} za hladjenje uzoraka ozracivanih u vertikalnim eksperimentalnim kanalima reaktora RA, Album I

    Energy Technology Data Exchange (ETDEWEB)

    Pavicevic, M; Pavlovic, A [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1963-06-15

    Project 'independent CO{sub 2} loop for cooling the samples irradiated in the vertical experimental channels of the RA reactor' is presented in two volumes: volume I - head of the low temperature coolant loop for reactor RA, and volume II - Outer low-temperature reactor coolant loop. Volume I includes: the design specifications for the head of the low-temperature coolant loop, technical description, thermal calculation, calculations of mechanical loads, antireactivity and activation of the components of the coolant loop head, engineering schemes and drawings, cost estimation data. [Serbo-Croat] Projekat 'Nezavisno kolo CO{sub 2} za hladjenje uzoraka ozracivanih u vertikalnim eksperimentalnim kanalima reaktora RA', sastoji se od dva albuma: album I - Glava niskotemperaturno rashladne petlje za reaktor RA, album II - Spoljno kolo niskotemperaturne rashladne petlje za reaktora. Album I sadrzi projektni zadatak glave niskotemperaturne petlje, tehnicki opis, termicki proracun, proracun mehanickih naprezanja, antireaktivnosti i aktivacije kontrukcionih elemenata glave petlje, konstrukcione seme i crteze glave petlje, predracun.

  20. Alteração na atenção e o tratamento da dor do câncer Alteración en la atención y el tratamiento del dolor de cáncer Alteration in attention and cancer pain treatment

    Directory of Open Access Journals (Sweden)

    Geana Paula Kurita

    2008-03-01

    Full Text Available Os danos à vida diária que a alteração cognitiva pode provocar motivaram a elaboração deste estudo, cujo objetivo foi analisar o impacto do tratamento da dor com opióides sobre a atenção. Os doentes foram divididos em grupos que recebiam (n=14 e não recebiam opióides (n=12. Foram feitas três entrevistas, utilizando-se o Trail Making Test e o Digit Span Test, que avaliam a atenção. Os grupos foram homogêneos nas variáveis sociodemográficas, dor e depressão; não foram homogêneos no índice de Karnofsky e no recebimento de analgésicos adjuvantes. Os doentes sem opióides tiveram melhor desempenho no Digit Span Test - ordem inversa, na segunda avaliação (p=0,29 e não foram observadas diferenças no Trail Making Test. As alterações observadas foram limitadas, mas, enquanto novos estudos não confirmem os achados, doentes, profissionais e cuidadores devem ser alertados dos possíveis efeitos deletérios dos opióides sobre a função cognitiva.Los daños a la vida diaria que la alteración cognoscitiva puede causar motivaron la elaboración de este estudio, cuyo objetivo fue analizar el impacto del tratamiento del dolor con los opioides en la atención. Los enfermos fueron divididos en grupos que recibieron (n=14 y no recibieron opioides (n=12. Fueron realizadas tres entrevistas utilizándose el Trail Making Test y el Digit Span Test, que evalúan la atención. Los grupos fueron homogéneos en las variables sociodemográficas, dolor y depresión; no fueron homogéneos en el índice de Karnofsky y en el suministro de analgésicos adyuvantes. Los pacientes sin opioides tuvieron mejor desempeño en el Digit Span Test - reverse order, en la segunda entrevista (p=0,29 y no se observaron diferencias en el Trail Making Test. Las alteraciones observadas fueron limitadas, sin embargo mientras nuevos estudios no confirmen los resultados, pacientes, profesionales y cuidadores deben ser alertados sobre los posibles efectos deletéreos de

  1. Increasing Malonyl-CoA Derived Product through Controlling the Transcription Regulators of Phospholipid Synthesis in Saccharomyces cerevisiae.

    Science.gov (United States)

    Chen, Xiaoxu; Yang, Xiaoyu; Shen, Yu; Hou, Jin; Bao, Xiaoming

    2017-05-19

    Malonyl-CoA is a precursor of a variety of compounds such as polyketides and flavonoids. In Saccharomyces cerevisiae, malonyl-CoA concentration is tightly regulated and therefore maintained at a very low level, limiting the production of malonyl-CoA-derived chemicals. Here we manipulated the phospholipid synthesis transcriptional regulators to control the malonyl-CoA levels and increase the downstream product. Through manipulating different regulators including Ino2p, Ino4p, Opi1p, and a series of synthetic Ino2p variants, combining with studying the inositol and choline effect, the engineered strain achieved a 9-fold increase of the titer of malonyl-CoA-derived product 3-hydroxypropionic acid, which is among the highest improvement relative to previously reported strategies. Our study provides a new strategy to regulate malonyl-CoA availability and will contribute to the production of other highly valued malonyl-CoA-derived chemicals.

  2. A. Vessel for pressure generation, B. Battery of the electrical heater P=30kW, Project of the main loop for irradiation of enriched UO{sub 2}, Zad. E-14-37-00-29, Vol. IV; A. Sud za generaciju pritiska; B. Baterija el. grejaca snage P=30kW, Projekat glavnog kola petlje za ozracivanje obogacenog UO{sub 2}, Zad. E-14-37-00-29, Album IV

    Energy Technology Data Exchange (ETDEWEB)

    Anastasijevic, P; Pavlovic, A [Institute of Nuclear Sciences Boris Kidric, Laboratorija za eksploataciju reaktora, Vinca, Beograd (Serbia and Montenegro)

    1968-11-15

    Vessel for pressure generation and the 30kW battery of the electrical heater belong to the Project of the main loop for irradiation of enriched UO{sub 2}. These two components of the irradiation loop are designed to attain and maintain the pressure and temperature of the cooling fluid. This report includes the description of the construction of the vessel for pressure generation and the battery of the electrical heater, control mechanical and electric calculations, needed tests, materials specifications, and overall and detailed engineering drawings. Sud za generaciju pritiska i baterija el. grejaca snage P=30kW pripadaju projektu glavnog kola petlje za ozracivanje obogacenog UO{sub 2}. Ova dva elementa glavnog kola petlje omogucavaju i odrzavaju pritisak i temperaturu rashadnog fluida. Ovaj izvestaj sadrzi opis konstrukcije suda za generaciju pritiska i baterije elektricnog grejaca, kontrolne mehanicke i elektricne proracune, zahtevana ispitivanja, specifikaciju materijala, sklopni crtez i detalje.

  3. [How aliphatic alcohols and ph affect reactional capability of the horse blood serum cholinesterase at its interaction with organophosphorus inhibitors].

    Science.gov (United States)

    Basova, N E; Kormilitsin, B N; Perchenok, A Iu; Rozengart, E V; Saakov, V S; Suvorov, A A

    2013-01-01

    There was studied action of aliphatic alcohols (ethanol, propanol, isopropanol, n-butanol, isobutanol, secbutanol, tretbetanol) and pH on various kinds of reactional capability the serum cholinesterase. At the alcohols-affected inhibition of the cholinesterase hydrolytic activity, the determining role was played not the total number carbon atoms in the alcohol molecule, but by the "effective length" of the carbohydrate chain. The fact that the presence of alcohols did not affect parameters of the reverse cholinesterase inhibition with onium ions tetramethylammonium and choline allows suggesting the absence of effect solvents on specific acetylcholine sorption in the enzyme active center. With aid of two rows of hydrophobic organophosphorus inhibitors (OPI), we have managed to estimate both the degree and the character itself of the modifying action of alcohols and pH on the process of irreversible inhibition of serum cholinesterase.

  4. On social femininatives in Serbian and other Slavic languages

    Directory of Open Access Journals (Sweden)

    Piper Predrag J.

    2016-01-01

    Full Text Available Social femininatives, such as Serbian pevačica, učiteljica, upravnica, available in all Slavic languages, have in recent decades become a subject of language policy based on political correctness in the field of gender relations. As part of this language policy, the requirement is put forward of creating feminine neologisms in respect of each masculine noun, designating a profession or social status. The use of the ideological and political criteria in order to change the grammatical structure of the language is typical of more or less all modern Slavic literary languages. A common feature of such language policy is their communicative and grammatical groundlessness. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 178021: Opis i standardizacija savremenog srpskog jezika

  5. Technical realisation of the VISA-II Project, Phase II, Chapter X, Vol. VI; Tehnicka realizacija projekta VISA-II, II faza, Glava X, Album VI

    Energy Technology Data Exchange (ETDEWEB)

    Pavicevic, M; Nikolic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1963-01-15

    The second phase of the 'Project VISA-2 described in this chapter of Vol. VI includes the project specifications and technical drawings of the 'measuring system of VISA-2 for testing the VISA-2 channels outside and in the reactor'. In addition to the task objective, description of the measuring system, action plan, description of the work done it contains the definition of the task 'Leak testing' and instructions for the instrumentation personnel on duty. [Serbo-Croat] Druga faza zadatka {sup T}ehnicka realizacija projekta VISA-2' opisana u ovom poglavlju Albuma VI, sadrzi tehnicki opis i crteze 'Mernog sistema VISA-2 i ispitivanje kanala VISA-2 van reaktora i u reaktoru'. Pored definicije zadatka, opisa mernog sistema VISA-2, razrade zadatka, tekstualnog dela projekta i opisa izvedenih radova, ovo poglavlje obuhvata definiciju i razradu podzadatka 'Ispitivanje hermeticnosti' i dodatak sa instrukcijama za dezurne instrumentatore u vezi eksperimenta VISA-2.

  6. Blisko tekstu – lektura krytyczna, dydaktyka uniwersytecka a teorie kulturowe

    Directory of Open Access Journals (Sweden)

    Tomasz Cieślak-Sokołowski

    2012-06-01

    Full Text Available Artykuł poświęcony jest próbie opisu miejsca interpretacji tekstu poetyckiego w dydaktyce uniwersyteckiej wobec wyzwań stawianych przez współczesne studia kulturowe. Autor podąża przede wszystkim za diagnozami amerykańskiej badaczki i krytyczki Marjorie Perloff, starając się zrekonstruować zasady, na jakich możliwa jest dziś bliska lektura tekstu poetyckiego. Artykuł zamyka opis dwóch metod aktywizujących uważną lekturę (close reading w perspektywie rozwoju nowych mediów.

  7. Advanced Field Investigations of Screw Piles and Columns / Zaawansowane Badania Terenowe Pali I Kolumn Wkrecanych

    Directory of Open Access Journals (Sweden)

    Krasiński A.

    2011-03-01

    Full Text Available Dla potrzeb projektu badawczego „Nosnosc i praca w gruncie pali wkrecanych” finansowanego przez Ministerstwo Nauki i Szkolnictwa Wyzszego - projekt nr N N506 369234 rozpoczeto badania terenowe pali i kolumn wkrecanych. W artykule opisano badania na pierwszym zorganizowanym do tego celu poletku doswiadczalnym. Przeprowadzono na nim badania trzech pali wkrecanych z uzyciem specjalnego systemu pomiarowego oraz w połaczeniu z badaniami podłoza gruntowego za pomoca sondowan CPTU oraz z pomiarami parametrów wykonawstwa pali (moment wkrecajacy i inne. Celem badan terenowych i całego projektu badawczego jest rozpoznanie charakteru pracy pali wkrecanych w gruncie oraz okreslenie zaleznosci pomiedzy wynikami sondowan CPT a oporami wkrecania i nosnoscia pali wkrecanych. W artykule zawarto opis przebiegu oraz podstawowe wyniki wykonanych badan.

  8. Importância da avaliação e padronização analgésica em serviços de emergência Importancia de la evaluación y estandartización analgésica en servicios de emergencia Importance of pain evaluation and standardization of analgesic medication in emergency services

    Directory of Open Access Journals (Sweden)

    Ana Marial Calil

    2010-01-01

    Full Text Available OBJETIVOS: Conhecer a medicação antiálgica utilizada em pacientes que sofreram acidentes de transporte, o padrão analgésico e pontuar a intensidade da dor. MÉTODOS: Estudo descritivo, exploratório e longitudinal com abordagem quantitativa, que abrangeu 100 pacientes envolvidos em acidentes de transporte admitidos para tratamento em hospital referência para trauma. RESULTADOS: A dor foi identificada em 90,0% dos pacientes, sendo as de forte e média intensidade as mais frequentes; não se encontrou prescrição antiálgica em 48% dos casos. Maior uso medicamentoso foi encontrado em vítimas com lesões em membros e nos sete casos em que a dor foi totalmente aliviada, 5 (66,7% foram utilizados opióides. CONCLUSÃO: A dor é um fenômeno comum associado ao trauma com sub-tratamento e sub-avaliação em nosso meio, e o uso de opióides para dores reconhecidamente muito intensas ainda é um recurso pouco utilizado na emergência, mesmo em pacientes hemodinamicamente estáveis e com Escala de Coma de Gasglow=15.OBJETIVOS: Conocer los medicamentos antiálgicos utilizados en pacientes que sufrieron accidentes de transporte, conocer el estándar analgésico y dar puntajes a la intensidad del dolor. MÉTODOS: Estudio descriptivo, exploratorio y longitudinal con abordaje cuantitativo, que comprendió 100 pacientes que sufrieron accidentes de transporte y fueron admitidos para tratamiento en un hospital de referencia para tratamiento de traumas. RESULTADOS: El dolor fue identificado en 90,0% de los pacientes, siendo los dolores más frecuentes los de fuerte y media intensidad; no se encontró prescripción antiálgica en 48% de los casos. El mayor uso medicamentoso fue encontrado en víctimas con lesiones en miembros y entre los siete casos en que el dolor fue totalmente aliviado, en 5 (66,7% fueron utilizados opiáceos. CONCLUSIÓN: El dolor es un fenómeno común asociado al trauma con sub-tratamiento y sub-evaluación en nuestro medio, y el uso

  9. Surface and Electrical Characterization of Conjugated Molecular Wires

    Science.gov (United States)

    Demissie, Abel Tesfahun

    This thesis describes the surface and electrical characterization of ultrathin organic films and interfaces. These films were synthesized on the surface of gold by utilizing layer by layer synthesis via imine condensation. Film growth by imine click (condensation) chemistry is particularly useful for molecular electronics experiments because it provides a convenient means to obtain and extend ?-conjugation in the growth direction. However, in the context of film growth from a solid substrate, the reaction yield per step has not been characterized previously, though it is critically important. To address these issues, my research focused on a comprehensive characterization of oligophenyleneimine (OPI) wires via Rutherford backscattering spectrometry (RBS), X-ray photoelectron spectroscopy (XPS), spectroscopic ellipsometry (SE), reflection-absorption infrared spectroscopy (RAIRS), and cyclic voltammetry (CV). In addition, we had the unique opportunity of developing the first of its kind implementation of nuclear reaction analysis (NRA) to probe the intensity of carbon atoms after each addition step. Overall the combination of various techniques indicated that film growth proceeds in a quantitative manner. Furthermore, the NRA experiment was optimized to measure the carbon content in self-assembled monolayers of alkyl thiols. The results indicated well-resolved coverage values for ultrathin films with consecutive steps of 2 carbon atoms per molecule. Another fundamental problem in molecular electronics is the vast discrepancy in the values of measured resistance per molecule between small and large area molecular junctions. In collaboration with researchers at the National University of Singapore, we addressed these issues by comparing the electrical properties of OPI wires with the eutectic gallium indium alloy (EGaIn) junction (1000 mum2), and conducting probe atomic force microscopy (CP-AFM) junction (50 nm2). Our results showed that intensive (i.e., area

  10. Indicators for wild animal offtake: methods and case study for African mammals and birds

    Directory of Open Access Journals (Sweden)

    Daniel J. Ingram

    2015-09-01

    Full Text Available Unsustainable exploitation of wild animals is one of the greatest threats to biodiversity and to millions of people depending on wild meat for food and income. The international conservation and development community has committed to implementing plans for sustainable use of natural resources and has requested development of monitoring systems of bushmeat offtake and trade. Although offtake monitoring systems and indicators for marine species are more developed, information on harvesting terrestrial species is limited. Building on approaches developed to monitor exploitation of fisheries and population trends, we have proposed two novel indicators for harvested terrestrial species: the mean body mass indicator (MBMI assessing whether hunters are relying increasingly on smaller species over time, as a measure of defaunation, by tracking body mass composition of harvested species within samples across various sites and dates; and the offtake pressure indicator (OPI as a measure of harvesting pressure on groups of wild animals within a region by combining multiple time series of the number of harvested individuals across species. We applied these two indicators to recently compiled data for West and Central African mammals and birds. Our exploratory analyses show that the MBMI of harvested mammals decreased but that of birds rose between 1966/1975 and 2010. For both mammals and birds the OPI increased substantially during the observed time period. Given our results, time-series data and information collated from multiple sources are useful to investigate trends in body mass of hunted species and offtake volumes. In the absence of comprehensive monitoring systems, we suggest that the two indicators developed in our study are adequate proxies of wildlife offtake, which together with additional data can inform conservation policies and actions at regional and global scales.

  11. Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae

    Science.gov (United States)

    Henry, Susan A.; Kohlwein, Sepp D.; Carman, George M.

    2012-01-01

    Due to its genetic tractability and increasing wealth of accessible data, the yeast Saccharomyces cerevisiae is a model system of choice for the study of the genetics, biochemistry, and cell biology of eukaryotic lipid metabolism. Glycerolipids (e.g., phospholipids and triacylglycerol) and their precursors are synthesized and metabolized by enzymes associated with the cytosol and membranous organelles, including endoplasmic reticulum, mitochondria, and lipid droplets. Genetic and biochemical analyses have revealed that glycerolipids play important roles in cell signaling, membrane trafficking, and anchoring of membrane proteins in addition to membrane structure. The expression of glycerolipid enzymes is controlled by a variety of conditions including growth stage and nutrient availability. Much of this regulation occurs at the transcriptional level and involves the Ino2–Ino4 activation complex and the Opi1 repressor, which interacts with Ino2 to attenuate transcriptional activation of UASINO-containing glycerolipid biosynthetic genes. Cellular levels of phosphatidic acid, precursor to all membrane phospholipids and the storage lipid triacylglycerol, regulates transcription of UASINO-containing genes by tethering Opi1 to the nuclear/endoplasmic reticulum membrane and controlling its translocation into the nucleus, a mechanism largely controlled by inositol availability. The transcriptional activator Zap1 controls the expression of some phospholipid synthesis genes in response to zinc availability. Regulatory mechanisms also include control of catalytic activity of glycerolipid enzymes by water-soluble precursors, products and lipids, and covalent modification of phosphorylation, while in vivo function of some enzymes is governed by their subcellular location. Genome-wide genetic analysis indicates coordinate regulation between glycerolipid metabolism and a broad spectrum of metabolic pathways. PMID:22345606

  12. Crash protectiveness to occupant injury and vehicle damage: An investigation on major car brands.

    Science.gov (United States)

    Huang, Helai; Li, Chunyang; Zeng, Qiang

    2016-01-01

    This study sets out to investigate vehicles' crash protectiveness on occupant injury and vehicle damage, which can be deemed as an extension of the traditional crash worthiness. A Bayesian bivariate hierarchical ordered logistic (BVHOL) model is developed to estimate the occupant protectiveness (OP) and vehicle protectiveness (VP) of 23 major car brands in Florida, with considering vehicles' crash aggressivity and controlling external factors. The proposed model not only takes over the strength of the existing hierarchical ordered logistic (HOL) model, i.e. specifying the order characteristics of crash outcomes and cross-crash heterogeneities, but also accounts for the correlation between the two crash responses, driver injury and vehicle damage. A total of 7335 two-vehicle-crash records with 14,670 cars involved in Florida are used for the investigation. From the estimation results, it's found that most of the luxury cars such as Cadillac, Volvo and Lexus possess excellent OP and VP while some brands such as KIA and Saturn perform very badly in both aspects. The ranks of the estimated safety performance indices are even compared to the counterparts in Huang et al. study [Huang, H., Hu, S., Abdel-Aty, M., 2014. Indexing crash worthiness and crash aggressivity by major car brands. Safety Science 62, 339-347]. The results show that the rank of occupant protectiveness index (OPI) is relatively coherent with that of crash worthiness index, but the ranks of crash aggressivity index in both studies is more different from each other. Meanwhile, a great discrepancy between the OPI rank and that of vehicle protectiveness index is found. What's more, the results of control variables and hyper-parameters estimation as well as comparison to HOL models with separate or identical threshold errors, demonstrate the validity and advancement of the proposed model and the robustness of the estimated OP and VP. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Environmental and health risks associated with reuse of wastewater for irrigation

    Directory of Open Access Journals (Sweden)

    Eman Shakir

    2017-03-01

    Full Text Available The present study focuses on the environmental and health risks associated with the use of treated wastewater produced from Al-Rustamia third extension plant for irrigation. The measured data are used to evaluate comprehensive pollution index (CPI and organic pollution index (OPI. The average CPI was found as 0.69 which indicated to be slightly polluted for all seasons and a similar result was also obtained with OPI, which is found to slightly vary in the range 1.29–1.60 which indicates as being to be contaminated. Also to evaluate its suitability for irrigation purposes, Sodium Adsorption Ratio (SAR, Soluble Sodium Percentage (SSP and Residual Sodium Carbonate (RSC were calculated following standard equations and found experimentally as (8.70, (74.76 and (2.68 respectively. Irrigation water classes are used for Salinity hazard (EC and Sodium hazard (SAR to assess water suitability for irrigation, and it is found that samples in summer and autumn in the class of C3-S1, indicate high salinity and low sodium water, while in spring and winter in the class of C4-S1, they indicate very high-salinity. Furthermore, the data indicate a slight to moderate degree of restriction on the use of this treated wastewater in irrigation due to chloride hazard. RSC value is more than 1.25 at all seasons, indicating that samples in summer and autumn are doubtful for irrigation purposes, while the samples in spring and winter are unsuitable for irrigation.

  14. Effect of Coating Parameters of the Buffer Layer on the Shape Ratio of TRISO-Coated Particles

    International Nuclear Information System (INIS)

    KIm, Weon Ju; Park, Jong Hoon; Park, Ji Yeon; Lee, Young Woo; Chang, Jong Hwa

    2005-01-01

    Fuel for high temperature gas-cooled reactors (HTGR's) consists of TRISO-coated particles. Fluidized bed chemical vapor deposition (FBCVD) has been applied to fabricate the TRISO-coated fuel particles. The TRISO particles consist of UO 2 microspheres coated with layers of porous pyrolytic carbon (PyC), inner dense PyC (IPyC), SiC, and outer dense PyC (OPyC). The porous PyC coating layer, called the buffer layer, attenuates fission recoils and provides void volume for gaseous fission products and carbon monoxide. The buffer layer, which has the highest coating rate among the coating layers, shows the largest variation of the coating thickness within a particle and a batch. This could be the most plausible source of an asphericity in the TRISO particles. The aspherical particles are expected to have an inferior fuel performance. Miller et al. have predicted that a larger stress is developed within the coating layers and thus the failure probability increases in the particles with high aspect ratios. Therefore, the shape of the TRISO-coated particles should be controlled properly and has been one of the important inspection items for the quality control of the fabrication process. In this paper, we investigated the effect of coating parameters of the buffer layer on the shape of the TRISO particles. The flow rate of coating gas and the coating temperature were varied to control the buffer layer. The asphericity of the TRISO-coated particles was evaluated for the various coating conditions of the buffer layer, but at constant coating parameters for the IPyC/SiC/OPyC layers

  15. Overall performance assessment of a combined cycle power plant: An exergo-economic analysis

    International Nuclear Information System (INIS)

    Sahin, Ahmet Z.; Al-Sharafi, Abdullah; Yilbas, Bekir S.; Khaliq, Abdul

    2016-01-01

    Highlights: • An exergo-economic analysis is carried out for a combined cycle power plant. • An overall performance index (OPI) is defined to analyze the power plant. • Four performance indicators and three scenarios are considered in the analysis. • The optimum configuration of the power plant differs for each scenarios considered. - Abstract: An exergo-economic analysis is carried out for a combined cycle power plant using the first law and the second law of thermodynamics, and the economic principles while incorporating GT PRO/PEACE Software Packages. An overall performance index (OPI) is defined to assess and analyze the optimum operational and design configurations of the power plant. Four performance indicators are considered for the analysis; namely, energy efficiency (ENE), exergy efficiency (EXE), levelized cost of electricity (COE), and the total investment (TI) cost. Three possible scenarios are considered in which different weight factor is assigned to the performance indicators when assessing the performance. These scenarios are: (i) the conventional case in which the levelized cost of electricity is given a high priority, (ii) environmental conscious case in which the exergy efficiency is given a high priority, and (iii) the economical case in which the total cost of investment is given a high priority. It is shown that the optimum size and the configuration of the power plant differ for each scenarios considered. The selection and optimization of the size and configuration of the power plant are found to be depending on the user priorities and the weight factors assigned to the performance indicators.

  16. The Elwha Science Education Project (ESEP): Engaging an Entire Community in Geoscience Education

    Science.gov (United States)

    Young, R. S.; Kinner, F.

    2008-12-01

    Native Americans are poorly represented in all science, technology and engineering fields. This under- representation results from numerous cultural, economic, and historical factors. The Elwha Science Education Project (ESEP), initiated in 2007, strives to construct a culturally-integrated, geoscience education program for Native American young people through engagement of the entire tribal community. The ESEP has developed a unique approach to informal geoscience education, using environmental restoration as a centerpiece. Environmental restoration is an increasingly important goal for tribes. By integrating geoscience activities with community tradition and history, project stakeholders hope to show students the relevance of science to their day-to-day lives. The ESEP's strength lies in its participatory structure and unique network of partners, which include Olympic National Park; the non-profit, educational center Olympic Park Institute (OPI); a geologist providing oversight and technical expertise; and the Lower Elwha Tribe. Lower Elwha tribal elders and educators share in all phases of the project, from planning and implementation to recruitment of students and discipline. The project works collaboratively with tribal scientists and cultural educators, along with science educators to develop curriculum and best practices for this group of students. Use of hands-on, place-based outdoor activities engage students and connect them with the science outside their back doors. Preliminary results from this summer's middle school program indicate that most (75% or more) students were highly engaged approximately 90% of the time during science instruction. Recruitment of students has been particularly successful, due to a high degree of community involvement. Preliminary evaluations of the ESEP's outcomes indicate success in improving the outlook of the tribe's youth towards the geosciences and science, in general. Future evaluation will be likewise participatory

  17. Material Performance of Fully-Ceramic Micro-Encapsulated Fuel under Selected LWR Design Basis Scenarios: Final Report

    International Nuclear Information System (INIS)

    Boer, B.; Sen, R.S.; Pope, M.A.; Ougouag, A.M.

    2011-01-01

    The extension to LWRs of the use of Deep-Burn coated particle fuel envisaged for HTRs has been investigated. TRISO coated fuel particles are used in Fully-Ceramic Microencapsulated (FCM) fuel within a SiC matrix rather than the graphite of HTRs. TRISO particles are well characterized for uranium-fueled HTRs. However, operating conditions of LWRs are different from those of HTRs (temperature, neutron energy spectrum, fast fluence levels, power density). Furthermore, the time scales of transient core behavior during accidents are usually much shorter and thus more severe in LWRs. The PASTA code was updated for analysis of stresses in coated particle FCM fuel. The code extensions enable the automatic use of neutronic data (burnup, fast fluence as a function of irradiation time) obtained using the DRAGON neutronics code. An input option for automatic evaluation of temperature rise during anticipated transients was also added. A new thermal model for FCM was incorporated into the code; so-were updated correlations (for pyrocarbon coating layers) suitable to estimating dimensional changes at the high fluence levels attained in LWR DB fuel. Analyses of the FCM fuel using the updated PASTA code under nominal and accident conditions show: (1) Stress levels in SiC-coatings are low for low fission gas release (FGR) fractions of several percent, as based on data of fission gas diffusion in UO 2 kernels. However, the high burnup level of LWR-DB fuel implies that the FGR fraction is more likely to be in the range of 50-100%, similar to Inert Matrix Fuels (IMFs). For this range the predicted stresses and failure fractions of the SiC coating are high for the reference particle design (500 (micro)mm kernel diameter, 100 (micro)mm buffer, 35 (micro)mm IPyC, 35 (micro)mm SiC, 40 (micro)mm OPyC). A conservative case, assuming 100% FGR, 900K fuel temperature and 705 MWd/kg (77% FIMA) fuel burnup, results in a 8.0 x 10 -2 failure probability. For a 'best-estimate' FGR fraction of 50

  18. The "oligoanalgesia problem" in the emergency care O "problema oligoanalgesia" no cuidado da emergência

    Directory of Open Access Journals (Sweden)

    Ana Maria Calil

    2007-01-01

    Full Text Available INTRODUCTION: Pain is a common occurrence in trauma victims that provokes harmful effects on the body. However, there is a gap in the literature about this problem, which is still underevaluated and undertreated in Brazil, especially concerning the use of opioids. OBJECTIVES: To estimate pain intensity and the use of analgesia in traffic accident victims. MATERIALS AND METHODS: A prospective study, involving 100 accident victims (traffic accidents, who were interviewed at 2 separate posttraumatic moments, in a reference hospital of the city of São Paulo. All the medications used for these victims were recorded. All patients displayed a Glasgow Coma Scale (ECGl of 15, had stable hemodynamic parameters, and were brought directly from the scene of the accident. RESULTS: Pain of moderate and severe intensity (in 90% of cases was the most noted. After a 3-hour period, a significant number of patients with pain (48% continued without analgesia, and few opioids were used. CONCLUSION: Pain is a common event associated with trauma. It is still undertreated and underevaluated in Brazil, and the use of opioids for admittedly very severe pain is not frequently employed in the Emergency Service even in hemodynamically stable patients and with a Glasgow Coma Scale of 15.INTRODUÇÃO: A dor é um evento comum em vítimas de trauma com efeitos nocivos ao organismo, no entanto, há uma lacuna na literatura sobre essa problemática ainda sub-avaliada e sub-tratada em nosso meio, sobretudo na utilização de opióides. OBJETIVOS: Aferir a intensidade dolorosa e o uso da analgesia em vítimas de acidentes de transportes. MATERIAL E MÉTODO: Estudo prospectivo, envolvendo 100 vítimas de causas externas (acidentes de transporte, que foram entrevistadas em dois momentos distintos pós-trauma em um hospital de referência no Município de São Paulo.. Foram anotadas todas as medicações em uso para essas vítimas. Todos os pacientes tinham Escala de Coma de Gasglow

  19. Los sectores institucionales en la producción científica española de difusión internacional

    Directory of Open Access Journals (Sweden)

    González–Albo, Borja

    2016-03-01

    Full Text Available Institutional sectors —groups of centers with similar characteristics and types of R&D— constitute an interesting unit of analysis that can also serve as a useful framework for benchmarking purposes in R&D studies. The analysis of Spanish scientific output included in the Web of Science database (2000–2011 shows the predominance of Universities (66%, followed by the Public Research Organisations (OPI (23% and the Health Sector (18%. Non–profit organizations (ESAL (10%, which include both Traditional Entities with non-Profit Aims (ETSAL and new Research Structures with non-Profit Aims (EISAL, show the highest impact values, regardless of whether indicators based on impact factors (normalised position, percentage of articles in the first quartile or on citations are used. Universities present a more evenly distributed thematic profile and it is the only sector specialized in fields such as Social Sciences, Humanities or Mathematics, while the Health Sector is highly specialized in Clinical Medicine. During the period studied, the different sectors tended to increase their scientific production, to publish in higher impact factor journals and to intensify the level of collaboration and internationalization of their publications. Especially noteworthy is the strong rise of non–profit organizations, in particular the case of EISAL, which conduct high impact research mainly in Biomedicine. No relationship has been found between the areas in which the sectors are specialized and those in which they obtain the highest impact.Los sectores institucionales, como agrupaciones de centros con características similares en su actividad y orientación a la investigación, constituyen una interesante unidad de análisis que puede servir además como marco de referencia en los estudios de I+D. El análisis de la producción científica de España (2000–2011 recogida en la base de datos Web of Science permite observar el predominio del sector

  20. Associação de fentanil ou sufentanil à bupivacaína a 0,5% isobárica em raquianestesia: estudo comparativo

    Directory of Open Access Journals (Sweden)

    Neves José Francisco Nunes Pereira das

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Desde a descoberta dos receptores opióides e um maior entendimento da neurofarmacologia da medula espinhal em relação à transmissão e inibição do impulso nociceptivo, tem aumentado o interesse na utilização de drogas por via subaracnóidea, em Anestesiologia e tratamento da dor. O presente estudo tem como finalidade avaliar prospectivamente a eficácia clínica da adição de fentanil (25 µg e sufentanil (5 µg à bupivacaína isobárica (10 mg,em pacientes submetidos à raquianestesia para tratamento cirúrgico de varizes de MMII. MÉTODO: Participaram do estudo 60 pacientes, estado físico ASA I e II, com idades abaixo de 60 anos, submetidos à raquianestesia para tratamento cirúrgico de varizes e divididos aleatoriamente em três grupos: B (bupivacaína isobárica 10 mg, BF (bupivacaína isobárica 10 mg e fentanil 25 µg e BS (bupivacaína isobárica 10 mg e sufentanil 5 µg.A raquianestesia foi realizada em decúbito lateral esquerdo, punção lombar entre L3-L4, com agulha de Quincke 27G. Após a raquianestesia foram avaliados: tempo de latência, o nível de bloqueio sensitivo e bloqueio motor. No período per-operatório foram anotados: hipotensão arterial, bradicardia, depressão respiratória, diminuição da saturação periférica da hemoglobina pelo oxigênio, náuseas, vômitos, prurido e tremor. No período pós-operatório foi pesquisado o tempo de analgesia. RESULTADOS: Os grupos foram homogêneos. O tempo de latência, o bloqueio motor e o tempo de analgesia não apresentaram diferença significativa. O nível de bloqueio sensitivo mostrou diferença entre o grupo controle e os grupos contendo opióides em todos os momentos estudados. Prurido foi o efeito colateral mais freqüente nos grupos contendo opióides. CONCLUSÕES: A adição de fentanil (25 µg e sufentanil (5 µg à bupivacaína a 0,5% isobárica (10 mg em raquianestesia altera o nível de bloqueio sensitivo.

  1. Hot deformation behavior and hot working characteristic of Nickel-base electron beam weldments

    Energy Technology Data Exchange (ETDEWEB)

    Ning, Yongquan, E-mail: ningke521@163.com [School of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an 710072 (China); Yao, Zekun; Guo, Hongzhen [School of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an 710072 (China); Fu, M.W. [Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (China)

    2014-01-25

    Highlights: • The Hot deformation behavior of electron beam (EB) Nickel-base weldments was investigated. • The constitutive equation represented by temperature, strain rate and true strain was developed. • Processing map approach was adopted to optimize the hot forging process of EB weldments. • True strain has a great effect on the efficiency of power dissipation (η). -- Abstract: The electron beam welding (EBW) of Nickel-base superalloys was conducted, and the cylindrical compression specimens were machined from the central part of the electron beam (EB) weldments. The hot deformation behavior of EB weldments was investigated at the temperature of 960–1140 °C and the strain rate of 0.001–1.0 s{sup −1}. The apparent activation energy of deformation was calculated to be 400 kJ/mol, and the constitutive equation that describes the flow stress as a function of strain rate and deformation temperature was proposed for modeling of the hot deformation process of EB weldments. The processing map approach was adopted to investigate the deformation mechanisms during the hot plastic deformation and to optimize the processing parameters of EB weldments. It is found that the true strain has a significant effect on the efficiency of power dissipation (η). The η value in the safe processing domain (1140 °C, 1.0 s{sup −1}) increases from 0.32 to 0.55. In the unsafe processing domain (1080 °C, 0.001 s{sup −1}), however, the η value greatly decreases with the increase of strain. When the strain is 0.40, the efficiency of power dissipation becomes negative. The flow instability is predicted to occur since the instability parameter ξ(ε) becomes negative. The hot deformation of EB weldments can be carried out safely in the domain with the strain rate range of 0.1–1.0 s{sup −1} and the temperature range of 960–1140 °C. When the height reduction is about 50%, the optimum processing condition is (T{sub opi}: 1140 °C, ε{sub opi}: 1.0 s{sup −1}) with

  2. Hot deformation behavior and hot working characteristic of Nickel-base electron beam weldments

    International Nuclear Information System (INIS)

    Ning, Yongquan; Yao, Zekun; Guo, Hongzhen; Fu, M.W.

    2014-01-01

    Highlights: • The Hot deformation behavior of electron beam (EB) Nickel-base weldments was investigated. • The constitutive equation represented by temperature, strain rate and true strain was developed. • Processing map approach was adopted to optimize the hot forging process of EB weldments. • True strain has a great effect on the efficiency of power dissipation (η). -- Abstract: The electron beam welding (EBW) of Nickel-base superalloys was conducted, and the cylindrical compression specimens were machined from the central part of the electron beam (EB) weldments. The hot deformation behavior of EB weldments was investigated at the temperature of 960–1140 °C and the strain rate of 0.001–1.0 s −1 . The apparent activation energy of deformation was calculated to be 400 kJ/mol, and the constitutive equation that describes the flow stress as a function of strain rate and deformation temperature was proposed for modeling of the hot deformation process of EB weldments. The processing map approach was adopted to investigate the deformation mechanisms during the hot plastic deformation and to optimize the processing parameters of EB weldments. It is found that the true strain has a significant effect on the efficiency of power dissipation (η). The η value in the safe processing domain (1140 °C, 1.0 s −1 ) increases from 0.32 to 0.55. In the unsafe processing domain (1080 °C, 0.001 s −1 ), however, the η value greatly decreases with the increase of strain. When the strain is 0.40, the efficiency of power dissipation becomes negative. The flow instability is predicted to occur since the instability parameter ξ(ε) becomes negative. The hot deformation of EB weldments can be carried out safely in the domain with the strain rate range of 0.1–1.0 s −1 and the temperature range of 960–1140 °C. When the height reduction is about 50%, the optimum processing condition is (T opi : 1140 °C, ε opi : 1.0 s −1 ) with the peak efficiency of 0

  3. Epistatic roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes.

    Directory of Open Access Journals (Sweden)

    Konstantin A Tsetsarkin

    2009-08-01

    Full Text Available Between 2005 and 2007 Chikungunya virus (CHIKV caused its largest outbreak/epidemic in documented history. An unusual feature of this epidemic is the involvement of Ae. albopictus as a principal vector. Previously we have demonstrated that a single mutation E1-A226V significantly changed the ability of the virus to infect and be transmitted by this vector when expressed in the background of well characterized CHIKV strains LR2006 OPY1 and 37997. However, in the current study we demonstrate that introduction of the E1-A226V mutation into the background of an infectious clone derived from the Ag41855 strain (isolated in Uganda in 1982 does not significantly increase infectivity for Ae. albopictus. In order to elucidate the genetic determinants that affect CHIKV sensitivity to the E1-A226V mutation in Ae. albopictus, the genomes of the LR2006 OPY1 and Ag41855 strains were used for construction of chimeric viruses and viruses with a specific combination of point mutations at selected positions. Based upon the midgut infection rates of the derived viruses in Ae. albopictus and Ae. aegypti mosquitoes, a critical role of the mutations at positions E2-60 and E2-211 on vector infection was revealed. The E2-G60D mutation was an important determinant of CHIKV infectivity for both Ae. albopictus and Ae. aegypti, but only moderately modulated the effect of the E1-A226V mutation in Ae. albopictus. However, the effect of the E2-I211T mutation with respect to mosquito infections was much more specific, strongly modifying the effect of the E1-A226V mutation in Ae. albopictus. In contrast, CHIKV infectivity for Ae. aegypti was not influenced by the E2-1211T mutation. The occurrence of the E2-60G and E2-211I residues among CHIKV isolates was analyzed, revealing a high prevalence of E2-211I among strains belonging to the Eastern/Central/South African (ECSA clade. This suggests that the E2-211I might be important for adaptation of CHIKV to some particular conditions

  4. Ação central do naloxone sobre as ß-endorfinas e hormônio luteinizante (LH em ovelhas ovariectomizadas e hipoglicêmicas

    Directory of Open Access Journals (Sweden)

    Angela Maria Xavier Eloy

    1999-01-01

    Full Text Available Com a finalidade de se investigar o efeito no Sistema Nervoso Central (SNC do opióide antagonista naloxone hidrocloride sobre a liberação do hormônio luteinizante (LH em ovelhas ovariectomizadas e hipoglicêmicas, utilizaram-se oito fêmeas mestiças oriundas das raças Mule e Suffolk, pesando 65,7 ± 3,6 kg. Duas semanas antes do início dos trabalhos, os animais foram canulados bilateralmente nos ventrículos. Foram feitos dois tratamentos (TI- animais não-estressados; TII- animais estressados, que foram subdivididos em três grupos (solução salina, 1 mg e 2 mg de naloxone. Os animais foram distribuídos, aleatoriamente, dentro das parcelas e foram feitas repetições com intervalo de uma semana, até que se alcançassem quatro observações por tratamento. No TI não se observou alteração nas concentrações de ß-endorfinas e LH, enquanto no TII, apesar de os animais não apresentarem alterações nos níveis de ß-endorfinas após injeção intracerebroventricular (i.c.v. de 1 mg de naloxone, observou-se diminuição significativa (p<0,05 após injeção (i.c.v. de 2 mg. No TII, as concentrações de LH aumentaram significativamente (p<0,05 após injeção (i.c.v. de 1 e 2 mg de naloxone. Conclui-se, portanto, que mesmo na ausência dos esteróides gonadais, os opióides endógenos estão envolvidos no controle do LH em animais hipoglicêmicos.

  5. Dor oncológica Oncologic pain

    Directory of Open Access Journals (Sweden)

    Carla Alves Costa

    2007-12-01

    Full Text Available A dor pode ser definida de várias formas, sendo habitualmente descrita como uma experiência sensorial e emocional desagradável associada a lesão tecidular real ou potencial, ou descrita em função de tal lesão. No doente oncológico, a dor pode estar relacionada com a neoplasia, com o seu tratamento, ou não ter relação com a doença neoplásica. A dor tem grande impacto no doente oncológico, significando agravamento do prognóstico ou morte próxima, daí a importância de uma abordagem e tratamento correctos. As opções para o tratamento farmacológico são várias, estando disponíveis analgésicos não opióides, opióides e co-analgésicos. Os autores pretendem com este artigo rever o tratamento farmacológico da dor e alertar para a importância do reconhecimento da dor como doença e da possibilidade de tratar e aliviar os doentes.Pain can be defined by several ways, but is usually describes as an unpleasant sensorial or emotional experience related to real or potential tissue damage, or described in terms of such damage. The cancer patient may experience pain related to the cancer itself, its treatment or not related at all with the oncologic disease. It has an extreme importance to the patient, as it is interpreted as a worsening of the prognosis or near death. Therefore it is extremely important a correct approach and treatment of cancer pain. Pain can be treated by pharmacologic, non-pharmacologic means and by more invasive procedures. The options for pharmacologic treatment are various, since nonopioid, opioid analgesics and co-analgesics. The authors present a review of the pharmacological treatment of cancer pain and alert to the importance of the recognition of pain as an illness and the possibility to be relieved.

  6. Peregrynant uczony. Rola biblioteki i książki w programie staropolskich podroży edukacyjnych XVII w.

    Directory of Open Access Journals (Sweden)

    Adam Kucharski

    2011-12-01

    Full Text Available Głównym celem niniejszego opracowania jest analiza roli i miejsca jakie pełniły księgi i księgozbiory w trakcie polskich podróży edukacyjnych w XVII w. Z natury rzeczy książki były integralnym elementem studiów, zarówno w kraju jak i poza jego granicami. Podręczniki historii, retoryki, filozofii czy matematyki i architektury militarnej odgrywały podstawową rolę w procesie edukacji akademickiej. Także staropolscy studenci podróżujący dla zdobycia wiedzy i umiejętności byli autorami drukowanych rozpraw wieńczących ich studia akademickie. Książka stanowiąca w epoce baroku cenne, a nierzadko główne, źródło wiedzy o świecie była także obiektem zainteresowania w aspekcie jej gromadzenia i przechowywania. Biblioteki stanowiły z pewnością ważny, chociaż nie najistotniejszy, składnik licznych peregrynacji. Chętnie odwiedzano biblioteki kościelne i miejskie, publiczne, a nawet prywatne. Charakterystycznym rysem ich opisów była jednak predylekcja do opisywania wszelakich ciekawych eksponatów tam oglądanych. Tendencja taka wyraźnie zdominowała długość i dokładność opisów księgozbiorów bibliotecznych. Właściwa dla kultury barokowej pasja do zdobywania wiedzy o rzadkich i osobliwych dziełach sztuki, wynalazkach technicznych, zwierzętach czy przedmiotach objawiała się także podczas zwiedzania gmachów bibliotek. Niejednokrotnie przeradzała się ona wyłącznie w chęć oglądania niezwykłych eksponatów stając się de facto rodzajem rozrywki.

  7. A shared memory based interface of MARTe with EPICS for real-time applications

    International Nuclear Information System (INIS)

    Yun, Sangwon; Neto, André C.; Park, Mikyung; Lee, Sangil; Park, Kaprai

    2014-01-01

    Highlights: • We implemented a shared memory based interface of MARTe with EPICS. • We implemented an EPICS module supporting device and driver support. • We implemented an example EPICS IOC and CSS OPI for evaluation. - Abstract: The Multithreaded Application Real-Time executor (MARTe) is a multi-platform C++ middleware designed for the implementation of real-time control systems. It currently supports the Linux, Linux + RTAI, VxWorks, Solaris and MS Windows platforms. In the fusion community MARTe is being used at JET, COMPASS, ISTTOK, FTU and RFX in fusion [1]. The Experimental Physics and Industrial Control System (EPICS), a standard framework for the control systems in KSTAR and ITER, is a set of software tools and applications which provide a software infrastructure for use in building distributed control systems to operate devices. For a MARTe based application to cooperate with an EPICS based application, an interface layer between MARTe and EPICS is required. To solve this issue, a number of interfacing solutions have been proposed and some of them have been implemented. Nevertheless, a new approach is required to mitigate the functional limitations of existing solutions and to improve their performance for real-time applications. This paper describes the design and implementation of a shared memory based interface between MARTe and EPICS

  8. Design and Thermal Analysis for Irradiation of Pyrolytic Carbon/Silicon Carbide Diffusion Couples in the High Flux Isotope Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gerczak, Tyler J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Smith, Kurt R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Petrie, Christian M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    Tristructural-isotropic (TRISO)–coated particle fuel is a promising advanced fuel concept consisting of a spherical fuel kernel made of uranium oxide and uranium carbide, surrounded by a porous carbonaceous buffer layer and successive layers of dense inner pyrolytic carbon (IPyC), silicon carbide (SiC) deposited by chemical vapor , and dense outer pyrolytic carbon (OPyC). This fuel concept is being considered for advanced reactor applications such as high temperature gas-cooled reactors (HTGRs) and molten salt reactors (MSRs), as well as for accident-tolerant fuel for light water reactors (LWRs). Development and implementation of TRISO fuel for these reactor concepts support the US Department of Energy (DOE) Office of Nuclear Energy mission to promote safe, reliable nuclear energy that is sustainable and environmentally friendly. During operation, the SiC layer serves as the primary barrier to metallic fission products and actinides not retained in the kernel. It has been observed that certain fission products are released from TRISO fuel during operation, notably, Ag, Eu, and Sr [1]. Release of these radioisotopes causes safety and maintenance concerns.

  9. Comprehensive evaluation of future site alternatives

    International Nuclear Information System (INIS)

    Shain, D.I.; Jones, M.E.; Ryan, K.

    1994-01-01

    Due to rapid changes occurring within the Nuclear Weapons complex, the need for integrated planning designed to combine multiple program needs into one strategic plan has become a necessity. This is more apparent as diverse DOE programs compete for dwindling resources. These programs range from traditional production operations, environmental and waste management, to facility transition, economic development, decontamination and decommissioning, and environmental restoration activities. Each program can influence another, thus increasing the difficulty of distinguishing program elements. The method in developing comprehensive plans becomes even more complicated when environmental compliance issues, regulatory agreements and stakeholder values are considered. AT the Department of Energy's (DOE) Rocky Flats Plant (RFP), all of these program conditions exist. This paper addresses a set of tools which are being developed at RFP that provides key planning elements and alternatives assessment for the DOE's Office of Planning and Integration (OPI) and National Environmental Policy Act (NEPA) Compliance Officer at RFP. This set of tools is referred to as the Systems Engineering Analysis (SEA)

  10. Measurement of zero power reactor dynamic response by cross correlation method; Merenje dinamickog odziva reaktora nulte snage kros korelacionom metodom

    Energy Technology Data Exchange (ETDEWEB)

    Kostic, Lj; Petrovic, M [Boris Kidric Institute of Nuclear Sciences Vinca, Beograd (Yugoslavia)

    1969-07-15

    Pulse response is comprehensive description of linear system dynamics. In this paper, cross correlation method was used for measuring the response of zero power reactor. Reactor system was perturbed by pseudo-random signal, which was cross correlated with the reactor signal responding to this perturbation on the digital ZUSE Z-23 computer. Cross-correlation functions were measured for different positions of stochastic oscillator and ionization chamber in the critical system. From numerical processing of performed experimental data, it was concluded that a more powerful faster computer would be needed for processing statistical experiments. In that case it would be possible to obtain information about spatial effects in the reactor and propagation of neutron waves in the multiplication medium. Impulsni odziv je potpuni opis dinamike linearnog sistema. Za merenje impulsnog odziva nultog reaktora, u ovom radu, koriscena je kros korelaciona metoda. Reaktorski sistem je perturbovan pseudoslucajnim signalom, koji je u digitalnom racunaru ZUSE Z-23 kroskorelisan sa signalom odziva reaktora na ove perturbacije. Merene su kroskorelacione funkcije za razlicite polozaje stohastickog oscilatora i jonizacione komore u kriticnom sistemu. Iz numericki obradjivanih eksperimenta namece se kao zakljucak da bi za obradu statistickih eksperimenata kod nultih reaktora bio potreban racunar veceg kapaciteta i brzine. U tom slucaju bi se iz ovako postavljenog eksperimenta moglo doci i do informacija o prostornim efektima u reaktoru i prostiranju neutronskih talasa kroz multiplikativnu sredinu. (author)

  11. Design and Development of Two Manipulators as a Key Element of a Space Robot Testing Facility

    Directory of Open Access Journals (Sweden)

    Seweryn Karol

    2015-09-01

    Full Text Available Podczas procesu projektowania układów sterowania robotów pracujących w warunkach mikrograwitacji niezbędna jest możliwość przeprowadzenia ich walidacji w relewantnym środowisku. Kluczowym problemem jest budowa stanowisk testowych pozwalających na analizowanie ruchu manipulatora umieszczonego na swobodnej bazie, której ruch odbywa się w trzech wymiarach. Artykuł zawiera opis dwóch stanowisk testowych wykorzystywanych do analizy działania algorytmów sterowania w zrobotyzowanych systemach satelitarnych. W artykule opisano symulator warunków mikrograwitacji w postaci manipulatora płaskiego ze swobodną bazą umieszczoną na łożyskach powietrznych oraz stanowisko testowe wyposażone w manipulator o 7 stopniach swobody z utwierdzona bazą pozwalającą na pomiar 3 składowych siły i momentu siły.

  12. Drugs of abuse detection in saliva based on actuated optical method

    Science.gov (United States)

    Shao, Jie; Li, Zhenyu; Jiang, Hong; Wang, Wenlong; Wu, Yixuan

    2014-12-01

    There has been a considerable increase in the abuse of drugs during the past decade. Combing drug use with driving is very dangerous. More than 11% of drivers in a roadside survey tested positive for drugs, while 18% of drivers killed in accidents tested positive for drugs as reported in USA, 2007. Toward developing a rapid drug screening device, we use saliva as the sample, and combining the traditional immunoassays method with optical magnetic technology. There were several methods for magnetic nanoparticles detection, such as magnetic coils, SQUID, microscopic imaging, and Hall sensors. All of these methods were not suitable for our demands. By developing a novel optical scheme, we demonstrate high-sensitivity detection in saliva. Drugs of abuse are detected at sub-nano gram per milliliter levels in less than 120 seconds. Evanescent wave principle has been applied to sensitively monitor the presence of magnetic nanoparticles on the binding surface. Like the total internal reflection fluorescence microscope (TIRFM), evanescent optical field is generated at the plastic/fluid interface, which decays exponentially and penetrates into the fluid by only a sub-wavelength distance. By disturbance total internal reflection with magnetic nanoparticles, the optical intensity would be influenced. We then detected optical output by imaging the sensor surface onto a CCD camera. We tested four drugs tetrahydrocannabinol (THC), methamphetamine (MAMP), ketamine (KET), morphine (OPI), using this technology. 100 ng mL-1 sensitivity was achieved, and obvious evidence showed that this results could be improved in further researches.

  13. Investigations on human error hazards in recent unintended trip events of Korean nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sa Kil; Jang, Tong Il; Lee, Yong Hee; Shin, Kwang Hyeon [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    According to the Operational Performance Information System (OPIS) which has been operated to improve the public understanding by the KINS (Korea Institute of Nuclear Safety), unintended trip events by mainly human errors counted up to 38 cases (18.7%) from 2000 to 2011. Although the Nuclear Power Plant (NPP) industry in Korea has been making efforts to reduce the human errors which have largely contributed to trip events, the human error rate might keep increasing. Interestingly, digital based I and C systems is the one of the reduction factors of unintended reactor trips. Human errors, however, have occurred due to the digital based I and C systems because those systems require new or changed behaviors to the NPP operators. Therefore, it is necessary that the investigations of human errors consider a new methodology to find not only tangible behavior but also intangible behavior such as organizational behaviors. In this study we investigated human errors to find latent factors such as decisions and conditions in the all of the unintended reactor trip events during last dozen years. To find them, we applied the HFACS (Human Factors Analysis and Classification System) which is a commonly utilized tool for investigating human contributions to aviation accidents under a widespread evaluation scheme. The objective of this study is to find latent factors behind of human errors in nuclear reactor trip events. Therefore, a method to investigate unintended trip events by human errors and the results will be discussed in more detail.

  14. Agent orange herbicides, organophosphate and triazinic pesticides analysis in olive oil and industrial oil mill waste effluents using new organic phase immunosensors.

    Science.gov (United States)

    Martini, Elisabetta; Merola, Giovanni; Tomassetti, Mauro; Campanella, Luigi

    2015-02-15

    New immunosensors working in organic solvent mixtures (OPIEs) for the analysis of traces of different pesticides (triazinic, organophosphates and chlorurates) present in hydrophobic matrices such as olive oil were developed and tested. A Clark electrode was used as transducer and peroxidase enzyme as marker. The competitive process took place in a chloroform-hexane 50% (V/V) mixture, while the subsequent enzymatic final measurement was performed in decane and using tert-butylhydroperoxide as substrate of the enzymatic reaction. A linear response of between about 10nM and 5.0μM was usually obtained in the presence of olive oil. Recovery tests were carried out in commercial or artisanal extra virgin olive oil. Traces of pesticides were also checked in the oily matrix, in pomace and mill wastewaters from an industrial oil mill. Immunosensors show good selectivity and satisfactory precision and recovery tests performed in olive oil gave excellent results. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Green-Ampt approximations: A comprehensive analysis

    Science.gov (United States)

    Ali, Shakir; Islam, Adlul; Mishra, P. K.; Sikka, Alok K.

    2016-04-01

    Green-Ampt (GA) model and its modifications are widely used for simulating infiltration process. Several explicit approximate solutions to the implicit GA model have been developed with varying degree of accuracy. In this study, performance of nine explicit approximations to the GA model is compared with the implicit GA model using the published data for broad range of soil classes and infiltration time. The explicit GA models considered are Li et al. (1976) (LI), Stone et al. (1994) (ST), Salvucci and Entekhabi (1994) (SE), Parlange et al. (2002) (PA), Barry et al. (2005) (BA), Swamee et al. (2012) (SW), Ali et al. (2013) (AL), Almedeij and Esen (2014) (AE), and Vatankhah (2015) (VA). Six statistical indicators (e.g., percent relative error, maximum absolute percent relative error, average absolute percent relative errors, percent bias, index of agreement, and Nash-Sutcliffe efficiency) and relative computer computation time are used for assessing the model performance. Models are ranked based on the overall performance index (OPI). The BA model is found to be the most accurate followed by the PA and VA models for variety of soil classes and infiltration periods. The AE, SW, SE, and LI model also performed comparatively better. Based on the overall performance index, the explicit models are ranked as BA > PA > VA > LI > AE > SE > SW > ST > AL. Results of this study will be helpful in selection of accurate and simple explicit approximate GA models for solving variety of hydrological problems.

  16. Nuclear Reactor RA Safety Report, Vol. 8, Auxiliary system; Izvestaj o sigurnosti nuklearnog reaktora RA, Knjiga 8, Pomocni sistemi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-11-01

    This volume describes RA reactor auxiliary systems, as follows: special ventilation system, special drainage system, hot cells, systems for internal transport. Ventilation system is considered as part of the reactor safety and protection system. Its role is eliminate possible radioactive particles dispersion in the environment. Special drainage system includes pipes and reservoirs with the safety role, meaning absorption or storage of possible radioactive waste water from the reactor building. Hot cells existing in the RA reactor building are designed for production of sealed radioactive sources, including packaging and transport. [Serbo-Croat] Ova knjiga obuhvata opis pomocnih sistem reaktora RA: sistem specijalne ventilacije, sistem specijalne kanalizacije, vruce komore, sistemi za unutrasnji transport. Ventilacioni sistem je znacajan deo sistema zastite i sigurnosti reaktora. Njegova je uloga da onemoguci disperziju radioaktivnih cestica u okolinu. Sistem specijalne kanalizacije sastoji se od agregata, cevovoda i rezervoara sa sigurnosnom armaturom i ima zadatak da prihvata i u sebe deponuje radioaktivne otpadne vode iz objekarta reaktora RA. U zgradi reaktora RA postoje vruce komore koje su namenjene za proizvodnju zatvorenih izvora zracenje, ukljucujuci i mehanicku obradu, prepakivanje i transport.

  17. Possibilities for power reactor structural material and fuel testing in reactor RA; Mogucnosti reaktora RA za testiranje konstrukcionih materijala i goriva energetskih reaktora

    Energy Technology Data Exchange (ETDEWEB)

    Martinc, R; Lazarevic, Dj; Stefanovic, D; Cupac, S; Pesic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1978-05-15

    Nuclear reactor RA at Vinca has been designed as a high flux general purpose research reactor. Among other it was intended to play a role of material testing reactor. A scope of activities of Material Laboratory and Reactor RA Department of Boris Kidric Institute is presented in this report. Reactor RA capacity for reactor structural material and fuel irradiation is also described. The increase of RA reactor irradiation capacity is based on the improvement of VISA type fuel channel for fast neutron irradiations, as well as on the general neutron flux increase, due to introduction of highly enriched uranium fuel into reactor core and the advanced in-core fuel management. The irradiation capacities described allow for the reactor material and fuel testing to the considerable extent. Istrazivacki reaktor RA u Vinci je projektovan kao visokofluksni istrazivacki reaktor opste namene. Pored ostalog, on je namenjen i za testiranje reaktorskih konstrukcionih materijala i goriva. U radu je dat pregled aktivnosti Laboratorije za materijale IBK i reaktora RA na tom podrucju, kao i opis povecanih mogucnosti reaktora RA za ozracivanje reaktorskih materijala i goriva u cilju njihovog testiranja. Povecanje mogucnosti reaktora RA zasniva se na usavrsavanju specijalnog gorivnog kanala tipa VISA (za ozracivanje materijala brzim neutronima), kao i na opstem povecanju neutronskog fluksa na osnovu uvodjenja i nacina koriscenja visokoobogacenog uranskog goriva u reaktoru RA. Opisane mogucnosti reaktora RA dozvoljavaju u znatnoj meri ispitivanje konstrukcionih materijala i goriva energetskih reaktora.

  18. Modeling of coated fuel particles irradiation behavior

    International Nuclear Information System (INIS)

    Liang Tongxiang; Phelip, M.

    2006-01-01

    In this report, PANAMA code was used to estimate the CP performance under normal and accident condition. Under the normal irradiation test (1000 degree C 625 efpd, 10% FIMA), for intact CP fuel, failure fraction is in the level of 10 -7 . As-fabricated SiC failed particles results in the through coatings failed particles much earlier than the intact particles does, OPyC layer does not fail immediately after irradiation starts. The significant failures start at beyond the burnup of about 7% FIMA. Under the accident condition, the calculated results showed that when the heating temperature is much higher than 1850 degree C, the failure fraction of coated particle can reach the level of 1 percent. The CP fuel fails significantly if it has a buffer layer thinner than 65 urn, SiC layer thinner than 30 μm. High burnup CP need to develop small size kernel, thick buffer layer and thick SiC layer. (authors)

  19. Climate variability and Great Plains agriculture

    International Nuclear Information System (INIS)

    Rosenberg, N.J.; Katz, L.A.

    1991-01-01

    The ways in which inhabitants of the Great Plains, including Indians, early settlers, and 20th century farmers, have adapted to climate changes on the Great Plains are explored. The climate of the Great Plains, because of its variability and extremes, can be very stressful to plants, animals and people. It is suggested that agriculture and society on the Great Plains have, during the last century, become less vulnerable to the stresses imposed by climate. Opinions as to the sustainability of agriculture on the Great Plains vary substantially. Lockeretz (1981) suggests that large scale, high cost technologies have stressed farmers by creating surpluses and by requiring large investments. Opie (1989) sees irrigation as a climate substitute, however he stresses that the Ogallala aquifer must inevitably become depleted. Deborah and Frank Popper (1987) believe that farming on the Plains is unsustainable, and destruction of shelterbelts, out-migration of the rural population and environmental problems will lead to total collapse. With global warming, water in the Great Plains is expected to become scarcer, and although improvements in irrigation efficiency may slow depletion of the Ogallala aquifer, ultimately the acreage under irrigation must decrease to levels that can be sustained by natural recharge and reliable surface flows. 23 refs., 2 figs

  20. Project RA Research nuclear reactor - Annual report 1993 with comparative review for the period 1991 - 1993; Projekat Istrazivacki nuklearni reaktor RA - Izvestaj za 1993. godinu, uz uporedni pregled za period 1991 - 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-15

    Research reactor RA Annual report for year 1993 is divided into two main parts to cover: (1) operation and maintenance and (2) activities related to radiation protection. First part includes 8 annexes describing reactor operation, activities of services for maintenance of reactor components and instrumentation, financial report and staffing. The ninth separate annex deals with the feasibility of RA reactor applications. Second part of the report is devoted to radiation protection issues and contains 4 annexes with data about radiation control of the working environment and reactor environment, description of decontamination activities, collection of radioactive wastes, and meteorology data. [Serbo-Croat] Godisnji izvestaj o radu nuklearnog reaktora RA za 1993. godinu sastoji se od dva dela: prvi deo obuhvata pogon i odzavanje reaktora RA, a drugi poslove zastite od zracenja na reaktoru RA. Prvi deo sadrzi 8 priloga, koji opisuju rad reaktora i poslove sluzbi za odrzavanje opreme i komponenti, finansijski izvestaj, kadrovsku strukturu osoblja reaktora. Poseban prilog razmatra mogucnosti koriscenja istrazivackog reaktora RA. Drugi deo izvestaja o poslovima zastite od zracenja sadrzi 4 priloga sa podacima radijacione kontrole radne sredine i okoline reaktora, opis poslova dekontaminacije i sakupljanja radioaktivnih materija, kao i meteoroloske podatke.

  1. Research nuclear reactor RA - Annual report 1992; Istrazivacki nuklearni reaktor RA - Izvestaj za 1992. godinu

    Energy Technology Data Exchange (ETDEWEB)

    Sotic, O [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1992-12-01

    Research reactor RA Annual report for year 1992 is divided into two main parts to cover: (1) operation and maintenance and (2) activities related to radiation protection. First part includes 8 annexes describing reactor operation, activities of services for maintenance of reactor components and instrumentation, financial report and staffing. Second annex B is a paper by Z. Vukadin 'Recurrence formulas for evaluating expansion series of depletion functions' published in 'Kerntechnik' 56, (1991) No.6 (INIS record no. 23024136. Second part of the report is devoted to radiation protection issues and contains 4 annexes with data about radiation control of the working environment and reactor environment, description of decontamination activities, collection of radioactive wastes, and meteorology data. [Serbo-Croat] Godisnji izvestaj o radu nuklearnog reaktora RA za 1992. godinu sastoji se od dva dela: prvi deo obuhvata pogon i odzavanje reaktora RA, a drugi poslove zastite od zracenja na reaktoru RA. Prvi deo sadrzi 8 priloga, koji opisuju rad reaktora i poslove sluzbi za odrzavanje opreme i komponenti, finansijski izvestaj, kadrovsku strukturu osoblja reaktora. Drugi prilog (B) je rad Z. Vukadina 'Recurrence formulas for evaluating expansion series of depletion functions' objavljen u casopisu Kerntechnik, 1991. Drugi deo izvestaja o poslovima zastite od zracenja sadrzi 4 priloga sa podacima radijacione kontrole radne sredine i okoline reaktora, opis poslova dekontaminacije i sakupljanja radioaktivnih materija, kao i meteoroloske podatke.

  2. Neutron Diffractometer; Neutronski difraktometar

    Energy Technology Data Exchange (ETDEWEB)

    Zivadinovic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1961-12-15

    RA nuclear reactor is considered as a relatively strong neutron source producing the thermal neutron flux of about 3x10{sup 13} n/cm{sup 2} sec when operating at nominal power of 6.5 MW. Neutron diffraction method is applied in the field of solid state physics, material science, crystallography, magnetism, nuclear physic. Neutron diffractometer at the RA reactor consists of: system for obtaining collimated neutron beam from the horizontal experimental channel neutron monochromator; goniometer and electronic equipment for measurements and collecting the the measurement data. Nuklearni reaktor RA koji pri radu na snazi od 6,5 MW ima fluks termalnih neutrona oko 3x10{sup 13} n/cm{sup 2} sec predstavlja relativno jak izvor neutrona. Tehnika difrakcije neutrona primenjuje se u istrazivanjima fizike crvstog stanja, strukture materijala, kristalografije, magnetizma, nuklearne fizike. Neutronski difraktometar na reaktoru RA sastoji se od sistema za dobijanje kolimisanog snopa neutrona kroz horizontalni kanal reaktora; neutroskog monohromatora; goniometra i elektronskih uredjaja za merenja i registrovanje rezultata. Ovaj izvestaj sadrzi detaljan opis i seme neutronskog difraktometra sa pratecom opremom i elektronskim komponentama.

  3. Factors affecting the corrosion of SiC layer by fission product palladium

    International Nuclear Information System (INIS)

    Dewita, E.

    2000-01-01

    HTR is one of the advanced nuclear reactors which has inherent safety system, graphite moderated and helium gas cooled. In general, these reactors are designed with the TRISO coated particle consist of four coating layers that are porous pyrolytic carbon (PyC). inner dense PyC (IPyC), silicon carbide (SiC), and outer dense PyC (OPyC). Among the four coating layers, the SiC plays an important role beside in retaining metallic fission products, it also provides mechanical strength to fuel particle. However, results of post irradiation examination indicate that fission product palladium can react with and corrode SiC layer, This assessment is conducted to get the comprehension about resistance of SiC layer on irradiation effects, especially in order to increase the fuel bum-up. The result of this shows that the corrosion of SiC layer by fission product palladium is beside depend on the material characteristics of SiC, and also there are other factors that affect on the SiC layer corrosion. Fuel enrichment, bum-up, and irradiation time effect on the palladium flux in fuel kernel. While, the fuel density, vapour pressure of palladium (the degree depend on the irradiation temperature and kernel composition) effect on palladium migration in fuel particle. (author)

  4. Information draft on the development of air standards for isopropyl benzene

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    Isopropyl benzene, also commonly referred to as cumene, is a colourless liquid with a sharp, penetrating odour. It is derived from the distillation of coal tar, naphtha and petroleum. It is used mainly as an intermediate in the production of phenol, acetone, and alpha-methyl styrene, all of which are components in plastic resins. Isopropyl benzene is also used as a solvent and thinner for paints and enamels and as an octane booster in aviation gasoline. In 1996, reported atmospheric releases in Canada amounted to 16.4 tonnes, of which 9.1 tonnes were from Ontario sources. Isopropyl benzene is not a significant threat to health in low concentrations. Inhalation exposure can cause dizziness, light-headedness and fainting. Contact with isopropyl benzene can irritate the skin, eyes, nose and mouth. The current Ontario half-hour interim Point of Impingement (OPI) standard and the one-hour Ambient Air Quality Criterion (AAQC) are both set at 100 microgram/cubic meter on the basis of the odour nuisance property of the substance. A review of applicable literature from world-wide sources (and summarized in this report) reveal that four US agencies have developed air quality criteria for isopropyl benzene based on the health effects of the compound. These criteria range from 9 to 585 micrograms/cubic meter for an annual average basis and from 87 to 400 microgram/cubic meter on a 24-hour basis. 40 refs., 1 tab., appendix.

  5. Acceptance Test Data for BWXT Coated Particle Batch 93164A Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    Coated particle fuel batch J52O-16-93164 was produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), or may be used as demonstration production-scale coated particle fuel for other experiments. The tristructural-isotropic (TRISO) coatings were deposited in a 150-mm-diameter production-scale fluidizedbed chemical vapor deposition (CVD) furnace onto 425-μm-nominal-diameter spherical kernels from BWXT lot J52L-16-69316. Each kernel contained a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO) and was coated with four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batch was sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batch was designated by appending the letter A to the end of the batch number (i.e., 93164A).

  6. Acceptance Test Data for Candidate AGR-5/6/7 TRISO Particle Batches BWXT Coater Batches 93165 93172 Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    Coated particle fuel batches J52O-16-93165, 93166, 93168, 93169, 93170, and 93172 were produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). Some of these batches may alternately be used as demonstration coated particle fuel for other experiments. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μmnominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A).

  7. Evaluation of powdery mildew-resistance of grape germplasm and rapid amplified polymorphic DNA markers associated with the resistant trait in Chinese wild Vitis.

    Science.gov (United States)

    Zhang, J; Zhang, Y; Yu, H; Wang, Y

    2014-05-09

    The resistance of wild Vitis germplasm, including Chinese and American wild Vitis and Vitis vinifera cultivars, to powdery mildew (Uncinula necator Burr.) was evaluated for two consecutive years under natural conditions. Most of the Chinese and North American species displayed a resistant phenotype, whereas all of the European species were highly susceptible. The Alachua and Conquistador accessions of Vitis rotundifolia species, which originated in North America, were immune to the disease, while Baihe-35-1, one of the accessions of Vitis pseudoreticulata, showed the strongest resistance among all Chinese accessions evaluated. Three rapid amplified polymorphic DNA (RAPD) markers, OPW02-1756, OPO11-964, and OPY13-661, were obtained after screening 520 random primers among various germplasm, and these markers were found to be associated with powdery mildew resistance in Baihe-35-1 and in some Chinese species, but not in any European species. Analysis of F₁ and F₂ progenies of a cross between resistant Baihe-35-1 and susceptible Carignane (V. vinifera) revealed that the three RAPD markers were linked to the powdery resistant trait in Baihe-35-1 plants. Potential applications of the identified RAPD markers for gene mapping, marker-assisted selection, and breeding were investigated in 168 F₂ progenies of the same cross. Characterization of the resistant phenotype of the selected F₂ seedlings for breeding a new disease-resistant grape cultivar is in progress.

  8. A shared memory based interface of MARTe with EPICS for real-time applications

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Sangwon, E-mail: yunsw@nfri.re.kr [National Fusion Research Institute (NFRI), Gwahangno 169-148, Yuseong-Gu, Daejeon 305-806 (Korea, Republic of); Neto, André C. [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, P-1049-001 Lisboa (Portugal); Park, Mikyung; Lee, Sangil; Park, Kaprai [National Fusion Research Institute (NFRI), Gwahangno 169-148, Yuseong-Gu, Daejeon 305-806 (Korea, Republic of)

    2014-05-15

    Highlights: • We implemented a shared memory based interface of MARTe with EPICS. • We implemented an EPICS module supporting device and driver support. • We implemented an example EPICS IOC and CSS OPI for evaluation. - Abstract: The Multithreaded Application Real-Time executor (MARTe) is a multi-platform C++ middleware designed for the implementation of real-time control systems. It currently supports the Linux, Linux + RTAI, VxWorks, Solaris and MS Windows platforms. In the fusion community MARTe is being used at JET, COMPASS, ISTTOK, FTU and RFX in fusion [1]. The Experimental Physics and Industrial Control System (EPICS), a standard framework for the control systems in KSTAR and ITER, is a set of software tools and applications which provide a software infrastructure for use in building distributed control systems to operate devices. For a MARTe based application to cooperate with an EPICS based application, an interface layer between MARTe and EPICS is required. To solve this issue, a number of interfacing solutions have been proposed and some of them have been implemented. Nevertheless, a new approach is required to mitigate the functional limitations of existing solutions and to improve their performance for real-time applications. This paper describes the design and implementation of a shared memory based interface between MARTe and EPICS.

  9. IRT i pomiar edukacyjny

    Directory of Open Access Journals (Sweden)

    Bartosz Kondratek

    2013-12-01

    Full Text Available Pod nazwą „item response theory” kryje się rodzina narzędzi statystycznych wykorzystywanych do modelowania odpowiedzi na rozwiązywane zadania oraz umiejętności uczniów. Modele IRT czynią to poprzez wprowadzenie parametryzacji, która określa: właściwości zadań oraz rozkład poziomu umiejętności uczniów. W artykule przedstawiony zostanie ogólny opis jednowymiarowego modelu IRT, przybliżone zostaną najczęściej stosowane modele dla zadań ocenianych dwupunktowo (2PLM, 3PLM, 1PLM oraz wielopunktowo (GPCM, a także zarysowana zostanie problematyka estymacji poziomu umiejętności. Artykuł ma za zadanie wprowadzić czytelnika w techniczne szczegóły związane z modelowaniem IRT oraz przedstawić wybrane zastosowania praktyczne w pomiarze edukacyjnym. Wśród zastosowań praktycznych omówiono wykorzystanie IRT w analizie skomplikowanych schematów badawczych, zrównywaniu/łączeniu wyników testowych, adaptatywnym testowaniu oraz przy tworzeniu map zadań.

  10. Serbian lexicology today: Current achievements and perspectives

    Directory of Open Access Journals (Sweden)

    Dragićević Rajna M.

    2017-01-01

    Full Text Available At the turn of 21st century Serbian lexicology is under the influence of the Slavic (predominantly Russian and Anglo-Saxon semanticists. Different semantic theories are used in language analyses in Serbian papers. Since the 1970s componential analysis had been a leading theory, but as of the 1990s Serbian lexicology has come under the influence of cognitive linguistics. There are more and more interdisciplinary investigations where linguistics is interwoven with psychology, communicology, and sociology. Often, lexicology is interwoven with other linguistic disciplines, such as syntax, word formation, morphology, stylistics, etc. Recently, some semantic studies have been conducted from the pragmatic viewpoint. Depending on the object of the analysis and the theory chosen, different research methods are used, such as collocational, associative, and additionally, various types of syntactic and semantic approaches are taken. The focus of interest is semantics of words, and less frequent of morphemes or sentences. The future of Serbian lexicology lies in promoting an interdisciplinary approach, and its relation with other linguistic disciplines and other nonlinguistic sciences. [Project of the Serbian Ministry of Education, Science and Technological Development: Opis i standardizacija savremenog srpskog jezika

  11. The Electronic Historical Latvian Dictionary Based on the Corpus of Early Written Latvian Texts

    Directory of Open Access Journals (Sweden)

    Everita Andronova

    2016-12-01

    Główny nacisk położono na opis haseł słownikowych, zawierający istotne uwagi praktyczne i teoretyczne. Omówiono poszczególne części hasła słownikowego, po czym umieszczono komentarz odnoszący się do różnych kwestii związanych z daną częścią (np. wybór hasła wyrazowego i przedstawienia wersji pisowni i do przyję­tych rozwiązań. Szczególną uwagę poświęcono główce hasła, objaśnieniu znaczenia wynikającego z przykładów występujacych w korpusie, różnym rodzajom kolokacji i ich przedstawieniu w słowniku, jak też informacjom etymologicznym. Na końcu zamieszczono zwięzły przegląd oprogramowania słownikowego TLex 2013, oparty na doświadczeniu autorów, zdobytym podczas pracy z tym narzędziem.

  12. Current perspectives of acute pain treatment Perspectivas actuales de tratamiento del paciente con dolor agudo

    Directory of Open Access Journals (Sweden)

    Tiberio Alvarez Echeverri

    1993-03-01

    Full Text Available

    In the last years opioids have become of great importance in the relief of postoperative and other forms of acute pain. Reasons for this trend have been the availability of agonist opioids like phentanyl. sulphentanyl and alphentanyl and the results of research on the physlology. The pharmacology and the chemistry of drug receptors and neurotransmitters. The studies on chemicals other than opioids that contribute to pain relief when administered through different ways. specially the spinal. Have also influenced such a trend.

    En los últimos años los opiáceos han adquirido gran importancia en el alivio del dolor agudo especialmente del tipo postoperatorio. Una de las razones ha sido la disponibilidad de morfínicos agonistas como el fentanil, el sufentanil y el alfentanil; otra es la investigación de la fisiología, la farmacología y la química de los receptores y los neurotransmisores como de sustancias diferentes a los opláceos, aplicadas por diferentes vías en especial la espinal, que coadyuvan al alivio del dolor.

  13. Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase

    Science.gov (United States)

    Nishimura, Akiko; Yamamoto, Katsuyoshi; Oyama, Masaaki; Kozuka-Hata, Hiroko

    2016-01-01

    In the budding yeast Saccharomyces cerevisiae, osmostress activates the Hog1 mitogen-activated protein kinase (MAPK), which regulates diverse osmoadaptive responses. Hkr1 is a large, highly glycosylated, single-path transmembrane protein that is a putative osmosensor in one of the Hog1 upstream pathways termed the HKR1 subbranch. The extracellular region of Hkr1 contains both a positive and a negative regulatory domain. However, the function of the cytoplasmic domain of Hkr1 (Hkr1-cyto) is unknown. Here, using a mass spectrometric method, we identified a protein, termed Ahk1 (Associated with Hkr1), that binds to Hkr1-cyto. Deletion of the AHK1 gene (in the absence of other Hog1 upstream branches) only partially inhibited osmostress-induced Hog1 activation. In contrast, Hog1 could not be activated by constitutively active mutants of the Hog1 pathway signaling molecules Opy2 or Ste50 in ahk1Δ cells, whereas robust Hog1 activation occurred in AHK1+ cells. In addition to Hkr1-cyto binding, Ahk1 also bound to other signaling molecules in the HKR1 subbranch, including Sho1, Ste11, and Pbs2. Although osmotic stimulation of Hkr1 does not activate the Kss1 MAPK, deletion of AHK1 allowed Hkr1 to activate Kss1 by cross talk. Thus, Ahk1 is a scaffold protein in the HKR1 subbranch and prevents incorrect signal flow from Hkr1 to Kss1. PMID:26787842

  14. Determination of trace mercury in water based on N-octylpyridinium ionic liquids preconcentration and stripping voltammetry.

    Science.gov (United States)

    Li, Zhenhan; Xia, Shanhong; Wang, Jinfen; Bian, Chao; Tong, Jianhua

    2016-01-15

    A novel method for determination of trace mercury in water is developed. The method is performed by extracting mercury firstly with ionic liquids (ILs) and then detecting the concentration of mercury in organic media with anodic stripping voltammetry. Liquid-liquid extraction of mercury(II) ions by four ionic liquids with N-octylpyridinium cations ([OPy](+)) was studied. N-octylpyridinium tetrafluoroborate and N-octylpyridinium trifluoromethylsulfonate were found to be efficient and selective extractant for mercury. Temperature controlled dispersive liquid phase microextraction (TC-DLPME) technique was utilized to improve the performance of preconcentration. After extraction, precipitated IL was diluted by acetonitrile buffer and mercury was detected by differential pulse stripping voltammetry (DPSV) with gold disc electrode. Mercury was enriched by 17 times while interfering ions were reduced by two orders of magnitude in the organic media under optimum condition. Sensitivity and selectivity for electrochemical determination of mercury were improved by using the proposed method. Tap, pond and waste water samples were analyzed with recoveries ranging from 81% to 107% and detection limit of 0.05 μg/L. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Trabajadores agrícolas y subjetividad en California

    Directory of Open Access Journals (Sweden)

    Florencio Posadas Segura

    2014-01-01

    Full Text Available En este trabajo se explora el problema de la subjetividad de los trabajadores agríco - las, partiendo de la hipótesis de que éstos consideran malas sus condiciones de vida y de trabajo. Mediante el trabajo de campo se demostraron sus conocimientos y opi - niones sobre su situación laboral y existencial en el Valle de San Joaquín California durante 2007 y 2008. Se descubrió que la visión del trabajador agrícola está basada en la subjetivación y reinterpretación de sus circunstancias objetivas de trabajo y de vida. Se concluyó que los trabajadores agrícolas opinan que sus condiciones son pé - simas porque sus derechos laborales, sociales y humanos no se reconocen o respetan, la crisis económica, social y política de Estados Unidos les perjudica y el Tratado de Libre Comercio entre México, Estados Unidos y Canadá ( TLCAN sólo podría beneficiarles con una reforma migratoria.

  16. Opinion - Thyroid (dysfunction in heart failure: is it a potential target for medical treatment?

    Directory of Open Access Journals (Sweden)

    Alessandro Pingitore

    2005-07-01

    Full Text Available Alessandro Pingitore, Giorgio IervasiInstitute of Clinical Physiology, CNR, Pisa, ItalyIntroductionCurrently, there is little doubt that activation of the neuroendocrine (NE system is predominately responsible for the progressive decline of heart function in heart failure (HF. This is due to the complex action of neurotransmitters, hormonal factors, and/or immunological pathways. Evidence that supports this point of view is the clear prognostic benefit and the reduction of HF progression by using NE-guided therapeutic approaches (SOLVD investigators 1992; Eichhorn and Bristow 1996; Packer et al 1996; Opie 2004; Solomon et al 2004. However, the fact that HF represents one of the major causes of morbidity and mortality in Western countries also suggests that the current portfolio of NE antagonists fails to completely explain and possibly counteract disease progression (Guyatt and Deveraux 2004. In this context, interest in the relationship between thyroid hormones (THs and HF is increasingly gaining prominence. The chief reason for the latter is the emerging novel actions of THs on the cardiovascular system and, more specifically, the role of TH as a prognostic biomarker of cardiac disease as well as the potential benefit of TH administration in patients with HF.

  17. Centralna Biblioteka Uniwersytecka Karola I w Bukareszcie

    Directory of Open Access Journals (Sweden)

    Iuliana Grażyńska

    2015-12-01

    Full Text Available W artykule omówione zostały doświadczenia, jakie autorka zdobyła podczas stażu w ramach programu Erasmus w Centralnej Bibliotece Uniwersyteckiej Karola I w Bukareszcie, jednej z najbardziej dotkniętych przez los bibliotek. Autorka odnotowuje różnice i podobieństwa między rumuńskim i polskim systemem bibliotecznym, omawia metody opracowywania książek w Oddziale Zbiorów Specjalnych, pozostałe usługi biblioteczne oraz przypomina burzliwą historię biblioteki. Bukareszteńska Biblioteka Uniwersytecka pierwsza w Rumunii wprowadziła zintegrowany system informacji. Książki opracowuje się w programie komputerowym opisów bibliograficznych VUBIS, który używa formatu UN IMAR C. Współpraca biblioteki z partnerami zagranicznymi pozwala na dostęp do najnowszych wyników badań i kompleksowych usług badawczych.

  18. Między kapitalizmem a socjalizmem. Marksistowska teoria okresu przejściowego

    Directory of Open Access Journals (Sweden)

    Paweł Szelegieniec

    2014-01-01

    Full Text Available Niniejszy artykuł jest próbą przybliżenia problematyki „okresu przejściowego”, jaki zdaniem teoretyków marksistowskich, powinien nastąpić po obaleniu kapitalizmu przez rewolucję robotniczą. Podstawowym odniesieniem są dla mnie poglądy, jakie prezentowali marksiści podczas trzech „debat ekonomicznych” na temat „budowy socjalizmu” (debata o kalkulacji, debata o planowaniu w ZSRR i na Kubie po rewolucji. W celu opisu, w jaki sposób marksizm podchodzi do kwestii postkapitalistycznej rzeczywistości, bazowałem głównie na pismach Karola Marksa, Fryderyka Engelsa, Lwa Trockiego i Ernesta Mandela, w oparciu o które próbowałem stworzyć zarys modelu społeczno-gospodarczego. Opis, jaki wyłania się z prac wymienionych autorów, przedstawia społeczeństwo oparte na demokracji robotniczej w miejscu pracy (aspekt ekonomiczny i na poziomie państwa (aspekt polityczny oraz planowaniu demokratycznemu, mającemu na celu sukcesywne zaspokajanie oraz bardziej złożonych potrzeb społecznych. Tak opisany model postkapitalistycznego społeczeństwa stanowi radykalnie zaprzeczenie rzeczywistości, jaka istniała w (poststalinowskich reżimach biurokratycznych.

  19. Relations of image quality in on-line portal images and individual patient parameters for pelvic field radiotherapy

    International Nuclear Information System (INIS)

    Heuvel, F. van den; Neve, W. de; Coghe, M.; Verellen, D.; Storme, G.

    1992-01-01

    The aims of the present study involving 566 pelvic fields on 13 patients were: 1. To study the machine- and patient-related factors influencing image quality. 2. To study the factors related to machine, patient and patient set-up, influencing the errors of field set-up. 3. To develop a method for predicting the camera settings. The OPI device consisted of a fluorescent screen scanned by a video camera. An image quality score on a scale 0-5 was given for 546/566 fields. In a univariate analysis, open field subtraction adversely affected the score. The image score of anterior fields was significantly better than that of posterior fields. Multivariate stepwise logistic regression showed that, in addition to anterior or posterior field and subtraction, gender was also a significant predictor of image score. Errors requiring field adjustments were detected on 289/530 (54.5%) evaluable fields or 229/278 (82.4%) evaluable patient set-ups. Multivariate logistic regression showed that the probability of performing an adjustment was significantly related to gender, image quality and AP-PA diameter. The magnitude of adjustments made in the lateral direction correlated significantly with patient bulk. The camera kV level with gain held constant showed an exponential dependency on dose rate at the image detector plate and can thus be predicted by treatment planning. (orig.)

  20. DATA ACQUISITION FOR SNS BEAM LOSS MONITOR SYSTEM

    International Nuclear Information System (INIS)

    YENG, Y.; GASSNER, D.; HOFF, L.; WITKOVER, R.

    2003-01-01

    The Spallation Neutron Source (SNS) beam loss monitor system uses VME based electronics to measure the radiation produced by lost beam. Beam loss signals from cylindrical argon-filled ion chambers and neutron detectors will be conditioned in analog front-end (AFE) circuitry. These signals will be digitized and further processed in a dedicated VME crate. Fast beam inhibit and low-level, long-term loss warnings will be generated to provide machine protection. The fast loss data will have a bandwidth of 35kHz. While the low level, long-term loss data will have much higher sensitivity. This is further complicated by the 3 decade range of intensity as the Ring accumulates beam. Therefore a bandwidth of 100kHz and dynamic range larger than 21 bits data acquisition system will be required for this purpose. Based on the evaluation of several commercial ADC modules in preliminary design phase, a 24 bits Sigma-Delta data acquisition VME bus card was chosen as the SNS BLM digitizer. An associated vxworks driver and EPICS device support module also have been developed at BNL. Simulating test results showed this system is fully qualified for both fast loss and low-level, long-term loss application. The first prototype including data acquisition hardware setup and EPICS software (running database and OPI clients) will be used in SNS Drift Tube Linac (DTL) system commissioning

  1. Dandismo y rebeldía en el Perú: el caso de Abraham Valdelomar

    Directory of Open Access Journals (Sweden)

    Mónica Bernabé

    2014-06-01

    Full Text Available Abraham Valdelomar fue un “hombre nómade, versátil, inquieto como su tiempo” apunta Mariátegui en sus Siete ensayos de interpretación de la realidad peruana. Nuestro interés reside, precisamente, en considerar ese nomadismo como una modalidad constituyente en la construcción de su imagen. Narrador, ensayista, periodista, poeta, caudillo político, apóstol del nacionalismo, novio fiel, homosexual, opiómano, hijo amantísimo, decadente, primitivo, Valdelomar es también el que inaugura la profesión de escritor en el Perú. Fue el primero que logró vivir de lo que escribía y de las conferencias que dictaba. Su nomadismo, esto es, las sucesivas transfiguraciones de su persona resistiendo a los esquemas establecidos, es la clave que nos permite leer en su obra los conflictos que desatan las tensiones entre artificio y autenticidad, entre presentación y representación, entre simulación y verdad. En este marco estudiamos con especial atención sus cuentos criollistas, sus crónicas periodísticas, su epistolario y los discursos y conferencias ofrecidos en ocasión de sus viajes patrióticos al interior del Perú.

  2. Gerenciamento de resultados contábeis em oferta pública de ações

    Directory of Open Access Journals (Sweden)

    Sylvia Rejane Magalhães Domingos

    2017-01-01

    Full Text Available Este estudio tuvo como objetivo investigar la práctica de la gestión de los ingresos por las empresas en períodos cercanos a la oferta pública de acciones. La muestra la formar on las compañías listadas en la BM&FBovespa que hic ieron OPI entre 2004 y 2013. Los modelos fueron utilizados Jones Modificado (1995 y Pae (2005 y se aplicó a la técnica de datos de panel. Los resultados del estudio sugieren que cuando las empresas gesti ona n sus resultados financieros para reducirlos , también buscan reducir la variabilidad de los beneficios, ya que cuando las empresas tratan de aumentar sus ganancias a través de la manipulación de beneficios es posible observar que esta práctica es más intensa en los trimestres en torno a la oferta pública.

  3. Investigations on human error hazards in recent unintended trip events of Korean nuclear power plants

    International Nuclear Information System (INIS)

    Kim, Sa Kil; Jang, Tong Il; Lee, Yong Hee; Shin, Kwang Hyeon

    2012-01-01

    According to the Operational Performance Information System (OPIS) which has been operated to improve the public understanding by the KINS (Korea Institute of Nuclear Safety), unintended trip events by mainly human errors counted up to 38 cases (18.7%) from 2000 to 2011. Although the Nuclear Power Plant (NPP) industry in Korea has been making efforts to reduce the human errors which have largely contributed to trip events, the human error rate might keep increasing. Interestingly, digital based I and C systems is the one of the reduction factors of unintended reactor trips. Human errors, however, have occurred due to the digital based I and C systems because those systems require new or changed behaviors to the NPP operators. Therefore, it is necessary that the investigations of human errors consider a new methodology to find not only tangible behavior but also intangible behavior such as organizational behaviors. In this study we investigated human errors to find latent factors such as decisions and conditions in the all of the unintended reactor trip events during last dozen years. To find them, we applied the HFACS (Human Factors Analysis and Classification System) which is a commonly utilized tool for investigating human contributions to aviation accidents under a widespread evaluation scheme. The objective of this study is to find latent factors behind of human errors in nuclear reactor trip events. Therefore, a method to investigate unintended trip events by human errors and the results will be discussed in more detail

  4. Safety report for the Independent CO{sub 2} loop for cooling the samples irradiated in the RA reactor vertical experimental channels, Vol. VI; Album VI: Izvestaj o sigurnosti za nezavisno kolo CO{sub 2} za hladjenje uzoraka ozracivanih u VEK reaktora RA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1964-07-01

    First part of the safety report for the Independent CO{sub 2} loop for cooling the samples irradiated in the RA reactor vertical experimental channels contains descriptions of the independent CO{sub 2} loop, system for regulation, measurement and control od the loop parameters, description of the dosimetry system, and the plan for testing the experimental device before start-up. Second part of this analysis describes the influence of of the experimental device on the reactor operation under steady state conditions as follows: influence of the head of the independent coolant loop on the reactivity of the reactor core and influence on the reactor temperature coefficient. Third part of the report includes the analysis of possible accidents during operation of the independent CO{sub 2} coolant loop in the reactor. Izvestaj o sigurnosti za nezavisno kolo CO{sub 2} za hladjenje uzoraka ozracivanih u VEK reaktora RA sadrzi u prvom delu: opis nezavisnog kola CO{sub 2}, sistema za regulaciju, merenje i kontrolu parametara nezavisnog kola, sistema dozimetrijske kontrole i plan ispitivanja eksperimentalnih uredjaja pre pustanja u rad. Drugi deo ove analize obuhvata uticaj eksperimentalnog uredjaja na reaktor u normalnom rezimu rada i to: uticaj glave petlje nezavisnog kola CO{sub 2} za hladjenje uzoraka na reaktivnost reaktora i uticaj uredjaja na temperaturni koeficijent reaktora. Treci deo sadrzi analizu mogucih akcidenata u toku rada nezavisnog kola CO{sub 2} u reaktoru.

  5. Development of a Radial Deconsolidation Method

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Montgomery, Fred C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-12-01

    A series of experiments have been initiated to determine the retention or mobility of fission products* in AGR fuel compacts [Petti, et al. 2010]. This information is needed to refine fission product transport models. The AGR-3/4 irradiation test involved half-inch-long compacts that each contained twenty designed-to-fail (DTF) particles, with 20-μm thick carbon-coated kernels whose coatings were deliberately fabricated such that they would crack under irradiation, providing a known source of post-irradiation isotopes. The DTF particles in these compacts were axially distributed along the compact centerline so that the diffusion of fission products released from the DTF kernels would be radially symmetric [Hunn, et al. 2012; Hunn et al. 2011; Kercher, et al. 2011; Hunn, et al. 2007]. Compacts containing DTF particles were irradiated at Idaho National Laboratory (INL) at the Advanced Test Reactor (ATR) [Collin, 2015]. Analysis of the diffusion of these various post-irradiation isotopes through the compact requires a method to radially deconsolidate the compacts so that nested-annular volumes may be analyzed for post-irradiation isotope inventory in the compact matrix, TRISO outer pyrolytic carbon (OPyC), and DTF kernels. An effective radial deconsolidation method and apparatus appropriate to this application has been developed and parametrically characterized.

  6. Heavy water pumps; Pumpe D{sub 2}O

    Energy Technology Data Exchange (ETDEWEB)

    Zecevic, V; Nikolic, M

    1963-12-15

    Continuous increase of radiation intensity was observed on all the elements in the heavy water system during first three years of RA reactor operation. The analysis of heavy water has shown the existence of radioactive cobalt. It was found that cobalt comes from stellite, cobalt based alloy which was used for coating of the heavy water pump discs in order to increase resistance to wearing. Cobalt was removed from the surfaces due to friction, and transferred by heavy water into the reactor where it has been irradiated for 29 876 MWh up to 8-15 Ci/g. Radioactive cobalt contaminated all the surfaces of aluminium and stainless steel parts. This report includes detailed description of heavy water pumps repair, exchange of stellite coated parts, decontamination of the heavy water system, distillation of heavy water. [Serbo-Croat] U toku prve tri godine eksploatacije reaktora RA uocen je neprekidni porast intenziteta zracenja na svim elementima u teskovodnom sistemu. Analizom teske vode utvrdjeno je postojanje radioaktivnog kobalta. Ustanovljeno je da kobalt potice od stelita, legure na bazi kobalta kojim su presvuceni rukavci vratila teskovodnih pumpi radi otpornosi na habanje. Kobalt je trenjem skidan sa povrsina, u toku rada prenosen je teskom vodom u reaktor i ozracivan u toku 29 876 MWh do specificne aktivnosti 8-15 Ci/g. Radioaktivni kobalt je kontaminirao sve povrsine od aluminijuma i nerdjajuceg celika. Ovaj izvestaj sadrzi detaljan opis remonta pumpi, zamene delova teskovodnih pumpi novim delovima bez stelitnog sloja, dekontaminacije teskovodnog sistema, destilacije teske vode.

  7. BADANIE MIESZANEK MINERALNO-ASFALTOWYCH W WARUNKACH ŚCINANIA PRZY KONTROLOWANEJ SZTYWNOŚCI WZDŁUŻNEJ

    Directory of Open Access Journals (Sweden)

    Adam ZOFKA

    2016-07-01

    Full Text Available W artykule przedstawiono koncepcję nowej metody badania próbek z mieszanki mineralno-asfaltowej w warunkach ścinania z ciśnieniem bocznym. Dotychczas stosowane metody badawcze ścinania z obciążeniem bocznym opierają się na ocenie właściwości mieszanki mineralno-asfaltowej przy ścinaniu w warunkach stałej siły wzdłużnej lub stałej objętości badanej próbki. Nowa metoda badawcza pozwala na badanie ścinania przy stałej sztywności wzdłużnej. Aby możliwe było badanie według tej metody, zaprojektowano i wykonano specjalną przystawkę o nazwie AST (ang. Advanced Shear Tester. W artykule przedstawiono zarówno opis procesu twórczego podczas projektowania przystawki, jak wykonane urządzenie. Zaprezentowano pierwsze wyniki badań walidacyjnych uzyskanych przy użyciu przystawki na próbkach UHMW-PE oraz z mieszanki mineralno-asfaltowej.

  8. Tagging genes for drought resistance by DNA markers in wheat (abstract)

    International Nuclear Information System (INIS)

    Malik, T.A.; Rahman, S.; Zafar, Y.

    2005-01-01

    Wheat families (F/sub 3) raised from the seed of drought resistant and susceptible F/sub 2/ plants developed from the cross of drought resistant and susceptible parents were grown under greenhouse conditions in polyethylene tubes filled with soil and sand mixture. Drought stress was imposed and monitored at the seedling stage. The relative water content and net photosynthesis was recorded with increasing drought stress until a significant part of the seedling population had zero or negative net photosynthesis. The seedling with zero or negative net photosynthesis were named as drought susceptible and the seedlings at the same drought stress showing net photosynthesis were named as drought resistance. Twenty each of the most susceptible and resistant seedlings were selected for DNA extraction. Random Amplified Polymorphic DNA (RAPD) technique using bulked segregant analysis was used to identify DNA markers linked to drought resistance. The primers OPJ-05, OPJ-14, OPI-20 and OPA-19 produced polymorphic DNA fragments between the contrasting bulks. The polymorphic DNA fragment of 1.55kb produced by the primer OPA-19 was found linked to drought resistance. This DNA marker can be used in markers-assisted selection for drought resistance or to clone drought resistance gene. (author)

  9. Funkcionalna nepismenost in kako jo rešujejo Francozi

    Directory of Open Access Journals (Sweden)

    Dušana Findeisen

    1998-12-01

    Full Text Available Dušana Findeisen piše o funkcionalni pismenosti in razpravlja o tem, kako je težko opredeljiva. Tako pravi, da se moramo zadovoljiti zgolj s tem, da opišemo značilne oblike te osebne in družbene disfunkcije, ki se spreminja s kulturnim okoljem in trenutkom družbenega razvoja. Ko omenja verbalnost, pove, da se funkcionalno nepismen človek tudi jezikovno in miselno oplaja le v svojem ozkem okolju in zato ni čudno, da se širših socialnih okolij boji. Izobraževanje in organizacija na tem področju sta povsem odvisna od ljudi, ki jih izobražujemo, in od tistih, ki so voljni takšno izobraževanje ponuditii. Tudi slednje je treba neprestano izobraževati, bodisi da gre za zaposlene strokovnjake, bodisi za prostovoljce. Vendarle pa to še ne pomeni, da jim lahko kar koli predpisujemo, jih kakor koli omejujemo ali nadzorujemo. Lahko jih zgolj spoštujemo. Podobno kot v Franciji pa bi bila potrebna politična volja na državni in lokalni ravni, da bi se dorekli mehanizmi izvajanja politike preprečevanja in zdravljenja tega velikega družbenega zla.

  10. Izobraževanje starejših odraslih in pomen njihovega izobraževanja za njih same ter družbo

    Directory of Open Access Journals (Sweden)

    Dušana Findeisen

    2009-12-01

    Full Text Available Avtorica predstavi pomen izobraževanja starejših odraslih za dejavno staranje v dolgem prehodnem obdobju, imenovanem »čas med delom, upokojitvijo in starostjo«. Ta koncept prehodnega obdobja, prehoda v starost, namreč danes nadomešča starejši koncept pokoja. V tem času ljudje v poznejših letih življenja opravljajo plačano delo, se izobražujejo, se (občasno vračajo na trg dela, delajo prostovoljno. Avtorica piše o prebivalstvenih spremembah in o pomenu izobraženosti vseh in vseh skupin starejših odraslih za soočanje s staranjem družbe. Dušana Findeisen zastane pri vprašanju značilnosti izobraževalnih programov za starejše odrasle, obravnava vrednote, nosilce in oblike izobraževanja starejših. Nazadnje opiše slovensko univerzo za tretje življenjsko obdobje kot konceptualno eno najbolj celostno domišljenih oblik in modelov izobraževanja ljudi v poznejših letih življenja.

  11. Pressure analysis in the fabrication process of TRISO UO2-coated fuel particle

    International Nuclear Information System (INIS)

    Liu Malin; Shao Youlin; Liu Bing

    2012-01-01

    Highlights: ► The pressure signals during the real TRISO UO2-coated fuel particle fabrication process. ► A new relationship about the pressure drop change and the coated fuel particles properties. ► The proposed relationship is validated by experimental results during successive coating. ► A convenient method for monitoring the fluidized state during coating process. - Abstract: The pressure signals in the coating furnace are obtained experimentally from the TRISO UO 2 -coated fuel particle fabrication process. The pressure signals during the coating process are analyzed and a simplified relationship about the pressure drop change due to the coated layer is proposed based on the spouted bed hydrodynamics. The change of pressure drop is found to be consistent with the change of the combination factor about particle density, bed density, particle diameter and static bed height, during the successive coating process of the buffer PyC, IPyC, SiC and OPyC layer. The newly proposed relationship is validated by the experimental values. Based on this relationship, a convenient method is proposed for real-time monitoring the fluidized state of the particles in a high-temperature coating process in the spouted bed. It can be found that the pressure signals analysis is an effective method to monitor the fluidized state on-line in the coating process at high temperature up to 1600 °C.

  12. DANCE AND SHAMANISM: MITH-RITUALISTIC EDUCATIONAL PROCESS IN GUARANI’S EVERYDAY LIFE

    Directory of Open Access Journals (Sweden)

    Ana Luisa Menezes

    2008-06-01

    Full Text Available Este artigo busca desenvolver uma reflexão sobre a dança Guarani e o xamanismo, enfocando os aspectos mitológicos e ritualísticos dentro de um processo educativo e cotidiano. Na dança, a consciência da coletividade é vivenciada através do pensamento e do sentimento. A vivência provocada pelo coletivo na dança pode ser traduzida como nhandereté, corpo de todos, como divina e produtora de alegria. Nas intempéries do cotidiano, o Guarani produz beleza e alegria, porque são a expressão de suas identidades divinas. Através de conversas e depoimentos com os jovens Guaranis, buscou-se enfocar as elaborações feitas por estes, do conhecimento mitológico e da vivência cotidiana.O rito cumpre uma função vivificadora do mito e estes dois aspectos são percebidos como entrelaçados à dança e à Opy. Todos estes aspectos são vividos pelos jovens e adultos de uma forma muito inquietante que os levam à um movimento permanente de indagações, buscas e redefinições. Dentro desse processo, a Opy, o Karaí e a dança são destacadas como fundantes da cultura Guarani e servem como pontos de estabilização dentro de um cotidiano tão dinâmico. A dança, enquanto rito, transporta os Guaranis a um tempo de reconhecimento de suas identidades, de um ritmo de vida. O rito Guarani está ligado a uma estrutura profunda de organização coletiva emocional, dentro de uma função vital, de elevação espiritual e uma integração ao seu sistema de pertença. Para os Guaranis, Nhanderú ensinou a dança e mandou dançar a dança. Esta surge de uma percepção mitológica e o seu surgimento confunde-se com a própria existência Guarani. A espiritualidade nasce de uma relação vital, de movimento.A educação xamânica é apreendida pelos sentidos. A noção principal de conhecimento é o Arandurekó, conhecimento que se aprende ao longo da vida, num tempo-ritmo próprio. A dança-rito possibilita a conexão entre corpo e espírito, proporcionando

  13. Comunicado acerca de las Sustancias que Producen Drogadicción

    Directory of Open Access Journals (Sweden)

    Academia Nacional de Medicina

    1994-09-01

    Full Text Available

    Informe y conclusiones de la Comisión designada por la Academia Nacional de Medicina para el estudio sobre DROGADICCIÓN, integrada por los Académicos Roberto De Zubiría, Coordinador; José Francisco Socarrás, Enrique Núñez Olarte, Mario Camacho Pinto, Guillermo Sánchez Medina y con intervención del Académico Fernando Sánchez Torres.

    La Comisión nombrada por la presidencia de la Academia Nacional de Medicina de Colombia para redactar las conclusiones sobre los trabajos presentados acerca de las sustancias que producen drogadicción, se ha reunido en varias oportunidades y determinado proponer a la consideración de la Academia las siguientes conclusiones:

    1. La drogadicción es una enfermedad neuropsicológica y social cuyo desarrollo frecuente suele ser el consumo abusivo de drogas para sentirse en condiciones placenteras y evitar el dolor o malestar corriente en la adaptación a las variedades ambientales y en consecuencia del trabajo o de las pesadumbres de la vida corriente. Es bien sabido que en el cerebro existen seis grupos de receptores opiáceos, de los cuales uno regula la conducta emocional, otro la percepción del dolor, y uno más la disforia, todo lo cual provoca las modificaciones respectivas en el comportamiento.

    2. Los farmacodependientes tienen un perfil caracterológico distorsionado; inmadurez flagrante, poderosas tendencias narcisistas y autodestructivas, exigencia a vivir sólo el presente de modo agradable y gratificante, incapacidad para enfrentar tensiones ante las cuales emplean la evasión y la negación de la realidad, mediante mecanismos imaginativos, para lo cual ciertas drogas son de una ayuda inigualable.

    3. Lo anterior implica que todo farmacodependiente requiere tratamiento médico, psiquiátrico y social, teniendo en cuenta la clase de fármacos a la que es adicto. Tales fármacos son los siguientes: a Los depresores que provocan dependencia física y

  14. Caracterização molecular de cultivares de cebola por marcadores RAPD Molecular characterization of onion cultivars by RAPD markers

    Directory of Open Access Journals (Sweden)

    Daniela L Leite

    2009-12-01

    Full Text Available Em plantas alógamas, as cultivares constituem uma fonte de variação genética planta-a-planta no qual o melhorista pode obter novos materiais. A variabilidade genética entre indivíduos ou populações tem sido medida através de marcadores moleculares. O objetivo deste trabalho foi avaliar molecularmente, através da análise de RAPD (Random Amplified Polimorphic DNA, a diversidade genética existente em um grupo de cultivares de cebola recomendadas para o cultivo na Região Sul do Brasil. Foram analisados 11 iniciadores em DNAs provenientes de um total de 90 plantas individuais oriundas das cultivares Baia Periforme, Bola Precoce, BRS Cascata, Crioula, Primavera e Roxa. As plantas foram genotipadas através dos produtos visualizados em gel de agarose e uma matriz de presença/ausência de bandas foi utilizada nas análises de similaridade genética (coeficiente de Jaccard e de agrupamento pelo método UPGMA. Os 11 iniciadores geraram 140 (86,4% bandas polimórficas. O número de fragmentos por iniciador variou de 10 (UBC105 até 18 (OPA10; OPC11; OPI1 com uma média de 15 bandas por iniciador. A técnica de RAPD mostrou-se eficiente na caracterização molecular, permitindo a formação de grupos de cultivares de acordo com a sua população de origem, com uma similaridade média de 63%. Conclui-se que as cultivares de cebola recomendadas para a Região Sul do Brasil, apresentam divergência genética, com potencial de serem exploradas por melhoristas, no desenvolvimento de genótipos superiores.In alogam plants, the cultivars constitute a source of plant-to-plant genetic variation from which the breeder can obtain new materials. Genetic variability among individuals or populations has been measured through molecular markers. The objective of this work was to evaluate the genetic diversity in a group of onion cultivars recommended for cultivation in the Southern Region of Brazil by RAPD (Random Amplified Polimorphic DNA analysis. Eleven

  15. Incidência de tremor em anestesia peridural com ou sem fentanil: estudo comparativo

    Directory of Open Access Journals (Sweden)

    Abreu Múcio Paranhos de

    2004-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A maioria dos trabalhos encontrados na literatura, relacionando a influência dos opióides administrados por via peridural com o tremor intra e pós-operatório, foram realizados com grupos de pacientes obstétricas, nas quais a resposta do centro termorregulador pode ser diferente das pacientes não grávidas. O objetivo deste trabalho foi comparar o bloqueio peridural com e sem fentanil, quanto à incidência de tremores e outras complicações no intra e pós-operatório em pacientes submetidos à cirurgia de varizes sob anestesia peridural com bupivacaína a 0,5% com adrenalina a 1:200.000. MÉTODO: Trinta e quatro pacientes, estado físico ASA I e II, submetidos à cirurgia para tratamento de varizes de membros inferiores, foram divididos aleatoriamente em 2 grupos (n = 17, e receberam midazolam (0,05 mg.kg-1, por via venosa seguido de anestesia peridural lombar, utilizando-se no grupo S, 20 ml bupivacaína a 0,5% (com vasoconstritor associado a 2 ml de solução fisiológica a 0,9% e no grupo F, 20 ml de bupivacaína a 0,5% (com vasoconstritor associada ao fentanil (100 µg. Foram estudados: incidência de tremor, temperatura dos pacientes, necessidade do uso de meperidina, e a incidência de náuseas e vômitos nos seguintes momentos: M1 - admissão do paciente na sala de operação; M2 - imediatamente antes da anestesia; M3 - 30 minutos após o término da injeção do anestésico local; M4 - 60 minutos após o término da injeção do anestésico local; M5 - 90 minutos após o término da injeção do anestésico local; M6 - final da anestesia; M7 - antecedendo a alta da sala de recuperação pós-anestésica. RESULTADOS: Quanto aos dados antropométricos, estado físico, tempo médio de duração da anestesia e cirurgia, temperatura dos pacientes e da sala de operação e incidência de náuseas e vômitos não houve diferença estatística entre os grupos. Houve diferença estatística aos 60 minutos (M4 e

  16. Consequence clauses with a meaning of measure and degree

    Directory of Open Access Journals (Sweden)

    Nikolić Marina M.

    2015-01-01

    Full Text Available The objective of this paper is to present a new classification of consequence clauses that is based on a category of degree. Based on that parameter, consequence clauses are classified into the ones that have a meaning of degree and the ones that don’t have that meaning. Furthemore, consequence clauses with a meaning of degree can be divided into the clauses with a meaning of measure (Napolju je toliko hladno da smo se odmah vratili iz šetnje./It is so cold outside that we had to return immediately back; On je takav prevarant, da će te sigurno preći/ He is such a chouse - he will cheat for sure. and into excessive clauses (Previše je debela da uđe u tu haljinu/ She is too fat to fit in this dress; Devojčica je premalena da ostane sama kod kuće/ The girl is too small to stay at home alone; Buka je bila dovoljna da natera dete u plač/The noise was loud enough to cause the baby cry. The article provides the arguments that the category of degree in this sentences is grammaticalized with the help of certain modifiers and a conjunction of result da. The author applies the onomasiological method in the analysis and uses the theory of semantic locations. An existence of certain meanings is confirmed by the transformational test. [Projekat Ministarstva nauke Republike Srbije, br. 178021: Opis i standardizacija savremenog srpskog jezika, potprojekat: Sintaksa složene rečenice

  17. Fat storage-inducing transmembrane (FIT or FITM proteins are related to lipid phosphatase/phosphotransferase enzymes

    Directory of Open Access Journals (Sweden)

    Matthew J Hayes

    2017-12-01

    Full Text Available Fat storage-inducing transmembrane (FIT or FITM proteins have been implicated in the partitioning of triacylglycerol to lipid droplets and the budding of lipid droplets from the ER. At the molecular level, the sole relevant interaction is that FITMs directly bind to triacyglycerol and diacylglycerol, but how they function at the molecular level is not known. Saccharomyces cerevisiae has two FITM homologues: Scs3p and Yft2p. Scs3p was initially identified because deletion leads to inositol auxotrophy, with an unusual sensitivity to addition of choline. This strongly suggests a role for Scs3p in phospholipid biosynthesis. Looking at the FITM family as widely as possible, we found that FITMs are widespread throughout eukaryotes, indicating presence in the last eukaryotic common ancestor. Protein alignments also showed that FITM sequences contain the active site of lipid phosphatase/phosphotransferase (LPT enzymes. This large family transfers phosphate-containing headgroups either between lipids or in exchange for water. We confirmed the prediction that FITMs are related to LPTs by showing that single amino-acid substitutions in the presumptive catalytic site prevented their ability to rescue growth of the mutants on low inositol/high choline media when over-expressed. The substitutions also prevented rescue of other phenotypes associated with loss of FITM in yeast, including mistargeting of Opi1p, defective ER morphology, and aberrant lipid droplet budding. These results suggest that Scs3p, Yft2p and FITMs in general are LPT enzymes involved in an as yet unknown critical step in phospholipid metabolism.

  18. Trudności diagnostyczne i terapeutyczne w przypadku ziarniniaka grzybiastego rozpoznanego wstępnie jako actinic reticuloid

    Directory of Open Access Journals (Sweden)

    Małgorzata Sokołowska-Wojdyło

    2010-07-01

    Full Text Available Wprowadzenie: Ziarniniak grzybiasty (mycosis fungoides – MF to chłoniako niskiej złośliwości, wywodzący się z obwodowych komórek T,pierwotnie zajmujący skórę. Cel pracy: Przedstawienie trudności diagnostycznych i terapeutycznychw MF. Opis przypadku: Przedstawiono przypadek dotyczący 72-letniejpacjentki z MF, objętej opieką przez Klinikę od października 2007 dowrześnia 2009 roku. Zmiany skórne miały cechy melanoerytrodermii,a obraz histopatologiczny wycinków ze zmian nie upoważniał do rozpoznaniarozrostu złośliwego. Początkowo rozpoznawano osutkępolekową oraz actinic reticuloid. Rozpoznanie MF ustalono dopiero po19 miesiącach obserwacji. Na skórze chorej wystąpiły zmiany rumieniowo-naciekowe, które w badaniu histopatologicznym miały cechyMF. Dwa miesiące później chora zmarła, mimo leczenia cytostatycznegoi naświetlań szybkimi elektronami. Wnioski: Przedstawiony przypadek potwierdza trudności diagnostycznewynikające z podobieństwa wczesnych okresów chłoniaka dodermatoz o podłożu zapalnym. Wyjątkowo niepomyślny przebieg choroby– pacjentka zmarła po 2 latach od momentu ustalenia rozpoznania– uzmysławia także ograniczenia możliwości terapeutycznych,szczególnie w zaawansowanych stadiach MF.

  19. Udział Książnicy Kopernikańskiej w tworzeniu bibliografii narodowej

    Directory of Open Access Journals (Sweden)

    Grzegorz Barecki

    2013-12-01

    Full Text Available Od 1 stycznia 2006 roku Wojewódzka Biblioteka Publiczna – Książnica Kopernikańska w Toruniu współtworzy elektroniczną bazę bibliograficzną „Artykuły z gazet i tygodników polskich (MARC21, 2005- ”. Stanowi ona część polskiej bieżącej bibliografii narodowej, wyodrębniła się bowiem z Bibliografii Zawartości Czasopism. Baza dostępna jest bezpłatnie w Internecie pod adresem: http://mak.bn.org.pl/cgi-bin/makwww.exe?BM=26 Wspólną Bazę Prasy w Książnicy Kopernikańskiej w Toruniu tworzą pracownicy Działu Informacyjno - Bibliograficznego. Obecnie opracowujemy w systemie MAK dwa tytuły: „Tygodnik Solidarność” i „Dziennik Gazetę Prawną”. Od 2006 roku wprowadziliśmy do bibliografii artykułów z gazet i tygodników już 33.998 rekordów bibliograficznych. Stanowi to 1/6 zawartości całej bazy tworzonej przez 14 bibliotek. Więcej opisów od nas stworzyła tylko Biblioteka Narodowa. Baza zawiera 209.404 dokumentów. Odwiedziło ją 599.408 użytkowników. Oznacza to, że ponad 1/3 sprawdzających Bibliografię Zawartości Czasopism korzysta ze Wspólnej Bazy Prasy. Dzieje się tak mimo, że rejestruje ona tylko 25 czasopism. Dowodzi to olbrzymiego zainteresowania naszą bazą i wskazuje na potrzebę dalszego jej rozwoju.

  20. Capsule HRB-15B postirradiation examination report

    International Nuclear Information System (INIS)

    Ketterer, J.W.; Bullock, R.E.

    1981-06-01

    Capsule HRB-15B design tested 184 thin graphite trays containing unbonded fuel particles to peak exposures of 6.6 x 10 25 n/m 2 (E > 29 fJ)/sub HTGR/ fast fluence, approx. 27% fissions per initial metal atom (FIMA) fissile burnup, and 6% FIMA fertile burnup at nominal time-averaged temperatures of 815 to 915 0 C. The capsule tested a variety of low-enriched uranium (approx. 19.5% U-235) fissile particle types, including UC 2 , UC/sub x/O/sub y/, UO 2 , zirconium-buffered UO 2 (referred to in this report as UO 2 /sup *), and 1:1(Th,U)O 2 with both TRISO and silicon-BISO coatings. All fertile particles were ThO 2 with BISO, silicon-BISO, or TRISO coatings. The findings indicated that all TRISO particles retained virtually all of their fission product inventories, except small quantities of silver, at these irradiation temperatures, while some of the silicon-BISO particles released significant amounts of both silver and cesium. No kernel migration, pressure vessel, or outer pyrolytic carbon (OPyC) failures were observed in the fuel particles, which had total diameters of 2 /sup */ particles exhibited no detrimental irradiation effects, but they contained pure carbon precipitates in the kernels after irradiation which were not observed in the undoped UO 2 particles. Postirradiation examination revealed no differences in the irradiation performance of three UC/sub x/O/sub y/ kernel types with varying oxygen/uranium ratios

  1. Zadarski akvatorij u Pîrî Reisovoj Knjizi pomorstva iz 1526. godine: Pomorsko-geografske slike dijela hrvatskoga Jadrana

    Directory of Open Access Journals (Sweden)

    Mithad Kozličić

    2015-01-01

    Full Text Available U radu su analizirane karte i tekstualni geografski opisi (peljar zadarskog akvatorija iz djela Kitâb-ı Bahriye (Knjiga pomorstva osmanskog moreplovca, pirata i kasnije admirala Pîrî Reisa. Komparativnom analizom sravnjeno je više primjeraka toga plovidbenog priručnika iz dosad poznatih istanbulskih izvora, ali i manje poznati primjerak iz Umjetničkog muzeja Walters (Walters Art Museum u Baltimoru. Cilj je bio usporediti saznanja koja su o širem zadarskom prostoru posredstvom skrovitog rada stranca iz neprijateljskih redova, Pîrî Reisa, dobili Osmanlije u odnosu na radove suvremenih mu mletačkih kartografa, kao “domaćina” na istočnoj jadranskoj obali. Preispitivanje njegova rada iz povijesno kartografske ali i imagološko-geografske perspektive pokazuje da je uspio izbalansirati potrebu za nastankom navigacijski i geografski iznimno kvalitetnog materijala s vlastitom pozicijom stranca na istočnom Jadranu. Kartografske i narativne slike Pîrî Reisa o zadarskom akvatoriju predstavljaju odraz dosega i mogućnosti osmanske kartografije što omogućuje njezino preispitivanje. Razlog leži u činjenici da kvaliteta kartografskog i narativnog dijela produkcije Pîrî Reisa nije dosegnuta u onodobnim plovidbenim priručnicima. Korištena toponimija upućuje na to da se Pîrî Reis služio tuđim dostupnim izvorima, primjerice uputama za plovidbu, ali ih je kombinirao s brojnim vlastitim opažanjima. Stoga njegov rad predstavlja posve izvoran opis zadarskog akvatorija, koji zbog obilja novih podataka donosi potpuno nove znanstvene spoznaje.

  2. EVALUACIÓN PSICOLÓGICA DEL ABUSO DE FÁRMACOS OPIOIDES

    Directory of Open Access Journals (Sweden)

    José Luis Carballo

    2016-01-01

    Full Text Available El incremento de la preinscripción de fármacos analgésicos opioides se ha asociado a un aumento de las tasas de abuso y las consecuencias negativas asociadas a su uso inadecuado. Diversos organismos sanitarios internacionales recomiendan la realización de una evaluación global y multidisciplinar del paciente durante todo el proceso terapéutico con opiáceos, con el fin de identificar un posible abuso. Ante la ausencia de quías específicas en el ámbito sanitario español, el objetivo de este artículo ha sido presentar una propuesta de evaluación psicológica, en base a los principales instrumentos de evaluación, disponibles actualmente para evaluar el abuso de opioides. Se establecen pautas para el proceso de evaluación en función de las variables psicológicas que puedan predecir y mantener dicho abuso, clasificando todo ello en función del momento del proceso terapéutico en el que los pacientes se encuentren, Aunque existen instrumentos con buenas propiedades psicométricas, son necesarias futuras investigaciones para la adaptación, traducción y validación de éstos a población española. Al mismo tiempo son necesarios futuros estudios que profundicen en estrategias de prevención e intervención para reducir la probabilidad de abuso en pacientes tratados con fármacos opioides.

  3. Neutron magnetic scattering experiments performed by VIKRA group at the RA reactor in Vinca; Eksperimenti grupe VIKRA na reaktoru RA u Vinci sa rasejanjem neutrona na magnetnim materijalima

    Energy Technology Data Exchange (ETDEWEB)

    Kranicki, S; Rzany, H; Wanic, A [Institute of Nuclear Physics, Krakov (Poland); Szytula, A [Jagiellonian University, Krakov (Poland); Todorovic, J; Dimitrijevic, Z; Radenkovic, S [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Yugoslavia)

    1978-05-15

    A short communication about investigations of magnetic materials by means of the neutron magnetic scattering performed by Polish-Yugoslav group VIKRA (Vinca-Krakov) at the RA reactor in Vinca in the period 1962-1977 will be presented. In the field of neutron inelastic scattering information about magnetic interactions (exchange integrals) and their temperature behaviour in such substances as Fe{sub 7}S{sub 8}, {alpha}-Fe{sub 2}O{sub 3}, CR{sub 2}O{sub 3}, {alpha}-Co, Cu{sub 2}MnAl and Mn{sub 1.88}Cr{sub 0.12}Sb was obtained by measuring magnon dispersion relations. In the field of neutron elastic scattering valuable results concerning crystallographic and magnetic structures of oxyhydroxides, several Heusler alloys and intermetallic compounds of 3d metals (for instance of NiMnGe, CoMnSi) were obtained. A short description of the KSN spectrometer used in all experiments will also be given. (author) Dato je kratko saopstenje o istrazivanjima magnetnih materijala magnetnim neutronskim rasejanjem izvrsenim od strane poljsko-jugoslovenske grupe VIKRA (Vinca-Krakov) na reaktoru RA u Vinci u periodu od 1962-1977. U oblasti neelasticnog rasejanja neutrona, obavestenja o magnetnim uzajamnim dejstvima (integralima izmene) i njihovim temperaturskim ponasanjima su dobijeni merenjem disperzione relacije magnona u takvim materijalima kao sto su Fe{sub 7}S{sub 8}, {alpha}-Fe{sub 2}O{sub 3}, CR{sub 2}O{sub 3}, {alpha}-Co, Cu{sub 2}MnAl and Mn{sub 1.88}Cr{sub 0.12}Sb. U oblasti neutronskog elasticnog rasejanja dobijeni su korisni rezultati o kristalografskim i magnetnim strukturama oksihidroksida gvozdja, niza Heuslerovih legura i intermetalnih jedinjenja 3d metala (napr. NiMnGe, Co,MnSi). Dat je kratak opis KSN spektrometra upotrebljenog u svim ovim eksperimentima. (author)

  4. Bases biológicas do transtorno de estresse pós-traumático Biological basis of posttraumatic stress disorder

    Directory of Open Access Journals (Sweden)

    Frederico G Graeff

    2003-06-01

    Full Text Available A pesquisa neuroendocrinológica dos sistemas fisiológicos envolvidos no estresse evidencia hiper função do eixo simpato-adrenal em conjunto com uma redução da atividade do eixo hipotálamo-hipófise-adrenal (HHA em pacientes com estresse pós-traumático (TEPT. Uma resposta prejudicada do cortisol aos estressores parece estar associada com um aumento da vulnerabilidade ao desenvolvimento do TEPT. O excesso de catecolaminas, sem o pareamento do aumento dos corticóides promoveria uma consolidação excessiva das memórias traumáticas e a indevida generalização para outras situações estressantes. Sintomas como o entorpecimento e flashbacks têm sido relacionados com o aumento de opióides endógenos. Estudos de neuroimagem evidenciam uma redução do volume hipocampal no TEPT, que tem sido relacionada a alterações cognitivas e anormalidades do eixo HHA encontrados no TEPT.Neuroendocrinological research on the physiological systems involved in stress evidenced hyper functioning of the sympatho-adrenal axis together with reduced activity of the hypothalamic-pituitary-adrenal axis in patients with posttraumatic stress disorder (PTSD. An impaired corticoid response to stressors seems to be associated with enhanced vulnerability to PTSD. Excess catecholamines, unchecked by corticoids would promote over consolidation of traumatic memories and undue generalization to other stressful situations. Symptoms such as numbing and flashbacks have been related to endogenous opioids. Neuroimaging studies evidenced a reduction of hippocampal volume in PTSD patients, which has been related to both cognitive changes and abnormalities of the HPA axis that are found in PTSD.

  5. Internações por intoxicações medicamentosas em crianças menores de cinco anos no Brasil, 2003-2012

    Directory of Open Access Journals (Sweden)

    Marta da Cunha Lobo Souto Maior

    Full Text Available RESUMO OBJETIVO: descrever as internações hospitalares devidas às intoxicações medicamentosas em menores de cinco anos de idade no Brasil, de 2003 a 2012. MÉTODOS: estudo descritivo, com dados do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS; os medicamentos envolvidos foram categorizados em classes terapêuticas, conforme a classificação Anatomical Therapeutic Chemical (ATC. RESULTADOS: foram identificadas 17.725 internações, com diagnóstico de 22.395 intoxicações e 75 óbitos; as classes terapêuticas mais frequentes nas intoxicações foram fármacos não especificados (38,0%, antiepilépticos/sedativo-hipnóticos/antiparkinsonianos (19,8%, antibióticos sistêmicos (13,4% e analgésicos/antitérmicos não opiáceos (6,5%, variando conforme região do país e idade das crianças; em 38,5% das intoxicações, não foi possível correlacionar classes terapêuticas e categorias ATC. CONCLUSÃO: a elevada frequência de fármacos não especificados foi uma limitação; entre as intoxicações com fármacos especificados, predominaram medicamentos que atuam no sistema nervoso central e aqueles utilizados em doenças comuns à infância (antibióticos e analgésicos.

  6. Apendagitis epiploica primaria: Clínica y evolución de 73 casos

    Directory of Open Access Journals (Sweden)

    Graciela M Vázquez

    2014-12-01

    Full Text Available La apendagitis epiploica primaria es una enfermedad relativamente infrecuente dentro de los diagnósticos diferenciales del abdomen agudo. Describimos las características clínicas y evolución de una serie de 73 casos de apendagitis epiploica primaria. Se realizó una búsqueda de imágenes ecográficas y tomográficas con diagnóstico de apendagitis en el sistema de información hospitalario electrónico del Hospital Alemán entre abril del 2007 y julio del 2013 y posteriormente se revisaron sus historias clínicas. Se incluyeron 73 casos; la edad promedio fue de 45 años (± 16, 54 (74% eran varones. El motivo de consulta fue dolor abdominal: en fosa ilíaca izquierda en 65 (el 89% de los casos; en fosa ilíaca derecha en seis (8% y en otras localizaciones en dos (3%. Se les realizó ecografía abdominal a 44 (60%, tomografía computarizada a 21 (29%, y ambos estudios a 8 (11%. En el 49% de los casos se solicitó interconsulta con el servicio de cirugía. Recibieron tratamiento con antibióticos 15 (21% pacientes, de los cuales el 73% fue indicado por un médico clínico. Recibieron tratamiento ambulatorio con antiinflamatorios no esteroides 67 (92%; dos requirieron cirugía laparoscópica, dos internación y dos opiáceos. La apendagitis epiploica es infrecuente dentro de los diagnósticos diferenciales de abdomen agudo, pero es una entidad que no debe ser desconocida por los médicos para prevenir intervenciones innecesarias y el uso excesivo de antibióticos.

  7. Devices for irradiation of materials in the fast neutron flux at the RA heavy water reactor in Vinca; Uredjaji za ozracivanje materijala u fluksu brzih neutrona na teskovodnom reaktoru RA u Vinci

    Energy Technology Data Exchange (ETDEWEB)

    Pavicevic, M [The Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Yugoslavia)

    1965-07-01

    Full text: This paper covers the concept, design description and problems of constructing special experimental devices at the RA reactor in Vinca. These devices were used for irradiation of construction materials (graphite, Mg and Al oxides, steel and zircaloy) in the integral fast neutron flux of 2 x 10{sup 20} n/cm{sup 2}. Temperature of samples cooled by heavy water circulating through the hollow uranium fuel elements was measured by thermocouples. Construction of the device, preparation of samples, related flux measurements as well as irradiation were done in cooperation with the nuclear center in Saclay, France. Brief review of the experiences gained in using these experimental spaces at the RA reactor as well as problems of transporting the irradiated capsules from Vinca to France is included. [Serbo-Croat] Pun tekst: Rad obuhvata koncepciju, tehnicki opis i probleme realizacije specijalnih eksperimentalnih uredjaja u reaktoru RA u Vinci, u kojima je tokom 1962. godine izvrseno, na temperaturama ispod 100 deg C, ozracivanje konstrukcionih materijala (grafita, Mg i Al-oksida, celika i cirkaloja) u integralnom fluksu brzih neutrona vrednosti 2 x 10{sup 20} n/cm{sup 2}. Temperatura uzoraka hladjenih teskom vodom, koja protice kroz suplje uranske elemente, merena je termoparovima. Realizacija uredjaja, priprema uzoraka, odgovarajuca merenja fluksa kao i sama ozracivanja vrsena su u saradnji sa Nuklearnim centrom u Saclay-u, Francuska. Dat je kraci pregled iskustava iz eksploatacije ovih novih eksperimentalnih prostora u reaktoru RA, kao i neki problemi vezani za transport aktivnih kapsula sa uzorcima od Vince do Saclay-a (author)

  8. Dr. House: Patología dual en el médico

    Directory of Open Access Journals (Sweden)

    Mariano A. BELLINA

    2016-09-01

    Full Text Available Dr. House es una serie dramática estadounidense cuyo personaje central es el Dr. Gregory House, médi? co que dirige una unidad de diagnóstico (con otros tres doctores en el Hospital Universitario Princeton? Plainsboro, en Nueva Jersey. Dr. House utiliza un proceso lógico especial como base para llegar al diagnóstico. La Unidad que dirige el Dr. House trata pacientes que han sido evaluados previamente por otros doctores sin haber alcanzado un diagnóstico. Los diagnósticos oscilan desde algunos muy comunes a enfermedades raras. House no respeta las reglas y procedimientos comunes en la Medicina tradicional, tiene conflictos interpersonales graves (así como falta de empatía y no muestra interés por otras prácticas clínicas que no sean las suyas. Sufre un dolor crónico intenso en la pierna derecha por el que comienza a prescribirse Vicodin® (hidrocodona, al que acaba haciéndose dependiente. Nuestra hipótesis es que House es un caso típico de patología dual, PD (coexistencia de trastorno por uso de sustancias y otra enfermedad mental, en concreto: de dependencia de opiáceos y trastorno mixto de personalidad (comparte rasgos del trastorno de la personalidad antisocial y narcisista. La PD no es infrecuente en médicos dada la demora en pedir ayuda y la fácil accesibilidad a algunas sustancias.

  9. Controle da dor no pós-operatório de cirurgia cardíaca: uma breve revisão

    Directory of Open Access Journals (Sweden)

    Luciano Ramos de Lima

    2008-06-01

    Full Text Available Este estudo teve como objetivo identificar as terapêuticas analgésicas para controle da dor no pós-operatório de pacientes submetidos à cirurgia cardíaca e os instrumentos utilizados para mensurar a experiência dolorosa. Trata-se de uma pesquisa bibliográfica realizada por meio de revisão da literatura nas bases de dados eletrônicos LILACS, revistas eletrônicas da SciELO, dissertações e teses. Foram utilizados os descritores analgesia, analgesia controlada pelo paciente, cirurgia cardíaca, avaliação e dor pós-operatória. O levantamento dos dados ocorreu em maio de 2007 e foram selecionados estudos publicados no período de maio de 1997 a maio de 2007. Na análise realizou-se síntese reflexiva dos estudos. Dos 23 estudos levantados foram utilizados 8 artigos e uma dissertação de mestrado. A técnica de analgesia mais utilizada foi a Analgesia Controlada pelo Paciente (ACP e os medicamentos mais utilizado foram os opióides, como a morfina, seguidos por antiflamatórios não esteroidais (AINEs e dipirona. Não foram encontrados estudos que utilizaram a terapêutica não farmacológica. Os instrumentos de avaliação de dor frequentemente utilizados nestes estudos incluíram as escalas unidimensionais como a escala numérica verbal e a escala analógica visual. Ficou também evidenciado que os enfermeiros estão pouco envolvidos em pesquisas que abordam o controle da dor no período pós-operatório de cirurgia cardíaca.

  10. Nuclear Reactor RA Safety Report, Vol. 9, Radiation protection; Izvestaj o sigurnosti nuklearnog reaktora RA, Knjiga 9, Zastita od zracenja

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-11-01

    Instrumentation for Radiation protection existing at the RA reactor is dating mostly from the period 1957-1959 when the reactor has been built. With some minor exception it was produced in USSR. Radiation protection system was constructed based on specific design project, somewhat modified original USSR project which has been indispensable because of some modification of the building design. During the past 27 years no renewal of the instrumentation was done, only maintenance was performed. Instrumentation consists of old electronic devices which caused difficulties and even prevented regular maintenance because of lack of spare parts. Instrumentation for radiation protection at the RA reactor is classified as follows: centralized dosimetry system; stationary dosimetry instrumentation, movable and personal dosimetry systems. Apart from the scheme of dosimetry instrumentation this volume includes description of radiation protection procedures; protection devices; radiation doses and dose limit data; program for environmental radioactivity control; medical control procedures. [Serbo-Croat] Instrumentacija za zastitu od zracenja koja danas postoji na reaktoru RA najvecim delom potice iz perioda 1957-1959 kada je reaktor gradjen. Sa malim izuzetcima instrumentacija je proizvedena u SSSR. Sistem za zastitu izveden je na osnovu posebnog projekta koji predstavlja modifikaciju originalnog projekta koja je bila neophodna usled modifikovanog gradjevinskog projekta. U proteklom periodu od 27 godina instrumentacija nije obnavljana vec je vrseno samo odrzavanje. Instrumentacija je izradjena u danas prevazidjenoh tehnoligiji (elektronske cevi) sto je otezavalo i skoro onemogucavalo normalno odrzavanje. Instrumentacija za zastitu od zracenja na reaktoru RA moze se podeliti na tri dela: centralizovani dozimetrijski sistem; stacionarna dozimetrijska instrumentacija; prenosna i licna dozimetrijska instrumentacija. Pored seme sistema dozimetrijske kontrole ova knjiga sadrzi opis

  11. Yeast PAH1-encoded phosphatidate phosphatase controls the expression of CHO1-encoded phosphatidylserine synthase for membrane phospholipid synthesis.

    Science.gov (United States)

    Han, Gil-Soo; Carman, George M

    2017-08-11

    The PAH1 -encoded phosphatidate phosphatase (PAP), which catalyzes the committed step for the synthesis of triacylglycerol in Saccharomyces cerevisiae , exerts a negative regulatory effect on the level of phosphatidate used for the de novo synthesis of membrane phospholipids. This raises the question whether PAP thereby affects the expression and activity of enzymes involved in phospholipid synthesis. Here, we examined the PAP-mediated regulation of CHO1 -encoded phosphatidylserine synthase (PSS), which catalyzes the committed step for the synthesis of major phospholipids via the CDP-diacylglycerol pathway. The lack of PAP in the pah1 Δ mutant highly elevated PSS activity, exhibiting a growth-dependent up-regulation from the exponential to the stationary phase of growth. Immunoblot analysis showed that the elevation of PSS activity results from an increase in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the CHO1 promoter indicated that Cho1 expression in the pah1 Δ mutant is induced through the inositol-sensitive upstream activation sequence (UAS INO ), a cis -acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. The abrogation of Cho1 induction and PSS activity by a CHO1 UAS INO mutation suppressed pah1 Δ effects on lipid synthesis, nuclear/endoplasmic reticulum membrane morphology, and lipid droplet formation, but not on growth at elevated temperature. Loss of the DGK1 -encoded diacylglycerol kinase, which converts diacylglycerol to phosphatidate, partially suppressed the pah1 Δ-mediated induction of Cho1 and PSS activity. Collectively, these data showed that PAP activity controls the expression of PSS for membrane phospholipid synthesis. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Development and use of a genitourinary pathology digital teaching set for trainee education

    Directory of Open Access Journals (Sweden)

    Li Li

    2010-01-01

    Full Text Available Background : Automated, high-speed, high-resolution whole slide imaging (WSI robots are becoming increasingly robust and capable. This technology has started to have a significant impact on pathology practice in various aspects including resident education. To be sufficient and adequate, training in pathology requires gaining broad exposure to various diagnostic patterns through teaching sets, which are traditionally composed of glass slides. Methods: A teaching set of over 295 glass slides has been used for resident training at the Division of Genitourinary Pathology, Department of Pathology, University of Pittsburgh Medical Center. Whole slide images were prepared from these slides using an Aperio ScanScope CS scanner. These images and case-related information were uploaded on a web-based digital teaching model. Results: The web site is available at: https://www.secure.opi.upmc.edu/genitourinary/index.cfm. Once logged in, users can view the list of cases, or search cases with or without diagnoses shown. Each case can be accessed through an option button, where the clinical history, gross findings are initially shown. Whole slide images can be accessed through the links on the page, which allows users to make diagnoses on their own. More information including final diagnosis will display when the diagnosis-button is clicked. Conclusion: The web-based digital study set provides additional educational benefits to using glass slides. Residents or other users can remotely access whole slide images and related information at their convenience. Searching and sorting functions and self-testing mode allow a more targeted study. It would also prepare residents with competence to work with whole slide images. Further, the model can be expanded to include pre-rotation and post-rotation exams, and/or a virtual rotation system, which may potentially make standardization of pathology resident training possible in the future.

  13. La orientación ideológica de los mensajes publicados en Twitter durante el 24M en España

    Directory of Open Access Journals (Sweden)

    Elías Manuel Said-Hung

    2017-01-01

    Full Text Available Los escenarios sociales digitales dispuestos en la actualidad son empleados cada vez más como plataformas para la deliberación y exposición de opi-niones. Es en el marco de lo aquí expuesto que este artículo busca identi-ficar algunos de los rasgos generales de participación ciudadana llevado a cabo en Twitter durante las elecciones realizadas en España el 24 de mayo de 2015, así como estimar el peso o la importancia que tuvieron los men-sajes con carga ideológica definida y las variables asociadas a la publicación de este tipo de mensajes. Ello, a partir del social media mining de 24 900 tuiteos, recolectados a partir de los hashtags #24M y #Elecciones2015. El estudio nos permite observar, entre otras cosas, el rol asumido por los ciu-dadanos, quienes centraron su participación en esta elección en la divul-gación del acontecer de esta jornada más que en el establecimiento de las diferentes posturas ideológicas que denotasen sus preferencias partidistas. A pesar de ello, se pudo ver cómo los mensajes con carga ideológica clara-mente definida estuvieron más impulsados por usuarios con orientación ideológica progresista o de tendencias de izquierda, además de la relación existente entre la publicación de estos mensajes y la orientación partidista de quienes divulgaron este tipo de mensajes.

  14. A study on the basic CVD process technology for TRISO coated particle fuel

    International Nuclear Information System (INIS)

    Choi, D. J.; Cheon, J. H.; Keum, I. S.; Lee, H. S.; Kim, J. G.

    2006-03-01

    Hydrogen energy has many advantages and is suitable as alternative energy of fossil fuel. The study of nuclear hydrogen production has performed at present. For nuclear hydrogen production, it is needed the study of VHTR(Very High Temperature Reactor) and TRISO(TRI-iSOtropic) coated fuel. TRISO coated fuel particle deposited by FBCVD(Fludized Bed CVD) method is composed of three isotropic layers: Inner Pyrolytic Carbon (IPyC), Silicon Carbide (SiC), Outer Pyrolytic Carbon (OPyC) layers. Silicon carbide was chemically vapor deposed on graphite substrate using methyltrichlorosilane (CH 3 SiCl 3 ) as a source in hydrogen atmosphere. The effect of deposition temperature and input gas ratios ( α=Q H2 /Q MTS =P H2 /P MTS ) was investigated in order to find out characteristics of silicon carbide layer. From results of those, SiC-TRISO coating deposition was conducted and achieved. Zirconium carbide layer as an advanced material of silicon carbide layer has studied. In order to find out basic properties and characteristics, studies have conducted using various methods. Zirconium carbide is chemically vapor deposed subliming zirconium tetrachloride(ZrCl 4 ) and using methan(CH 4 ) as a source in hydrogen atmosphere. Many experiments were conducted on graphite substrate about many deposition conditions such as ZrCl 4 heating temperatures and variables of H2 and CH 4 flow rate. but carbon graphite was deposited. For deposition of zirconium carbide, several different methods were approached. so zirconium carbide deposed on ZrO 2 substrate. In this experiments. source subliming type and equipment are no problems. But deposition of zirconium carbide will be continuously studied on graphite substrate approaching views of experimental way and equipment structure

  15. Report of the Technology Service - Annex B; Prilog B - Izvestaj o radu tehnoloske sluzbe

    Energy Technology Data Exchange (ETDEWEB)

    Cupac, S; Vukadin, Z [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1992-01-01

    This annex covers: description of the organisational structure of the service, safeguard activities, increase of reactor operation capability, dosimetry and radiation protection tasks and an overview of the the activities of this Service. During 1992, there have been 12 safeguard IAEA inspections. Each time inspection covered fresh fuel, every third inspection included control of the spent fuel storage pool, and once during the fuel inventory control the reactor core was included. With the aim of increasing the operating capabilities besides improvement of experimental devices, construction of the experimental loop with separate cooling system was started. It is planned, as well to improve operating capabilities of horizontal experimental channels by purchasing neutron diffractometer, constructing three-crystal neutron spectrometer, application of three-crystal neutron spectrometer from Krakow, and using the time-of flight spectrometer constructed in the Institute. This Annex describes the possible activities for neutron radiography and isotope production, and includes radiation protection data. [Serbo-Croat] Ova prilog sadrzi opis organizacije tehnoloske sluzbe, 'safeguard' aktivnosti, moguce poboljsanje eksploatacionih mogucnosti reaktora, tehnicke zastite od zracenja i dozimetrije, kao i pregled svih poslova Sluzbe. Tokom 1992. bilo je 12 'safeguard' IAEA inspekcija. Tokom svake inspekcije kontrolisano je sveze gorivo, svaka treca je ukljucila kontrolu bazena za odlezavanje ozracenog goriva, a jednom je kontrolisano i jezgro reaktora RA. Sa ciljem da se poboljsaju operativne mogucnosti reaktora, pored poboljsanja eksperimentalnih uredjaja, pocela je i izgradnja reaktorske petlje sa sopstvenim hladjenjem. Planirano je da se poboljsaju i operativne mogucnosti horizontalnih eksperimentalnih kanala, sto je ucinjeno kupovinom neutronskog difraktometra, izgradnjom trikristalnog neutronskog spektrometra, koriscenjem trikristalnog neutronskog spektrometra koji je

  16. Thelazia Callipaeda and Eye Infections

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    Otašević Suzana

    2014-09-01

    Full Text Available Infekcije oka mogu da izazovu metazoe-helminti. Dugo se za ove parazitoze verovalo da su rasprostranjene samo u tropskim krajevima sveta. U poslednje vreme najčešće su opisane subkonjuktivalne infekcije adultima ili nezrelim formama vrste D. repens, koje su filarije kanida i za koje je čovek samo slučajni nosilac. S obzirom na činjenicu da se na teritoriji grada Niša dijagnostikuje telazioza (thelasiosis kod pasa, opis morfoloških karakteristika roda, životnog ciklusa, rasprostranjenosti i kliničkog značaja ovog uzročnika zoonoza prvenstveno je bio cilj ovog rada. Rod Thelazia (Spirurida, Thelaziidae obuhvata kosmopolitsku grupu očnih crva spirurids, odgovornih za očne infekcije domaćih i divljih životinja i ljudi koje se prenose različitim vrstama mušica. Morfološki odrasli crvi su kremasto bele boje, končastog izgleda, dužine do 2 cm. Dokazano je da su muve reda Diptera, porodice Drosophilidae, roda Phortica, vektori i prelazni domaćini vrste T. callipaeda. Nematode lokalizovane u konjunktivalnom prostoru, suznim putevima i okolnim okularnim tkivima kanida, felida, glodara i ljudi, mogu izazvati blage simptome (pojačano suzenje, svrab, osećaj stranog tela, bol, otok, zamagljen vid, eksudativni konjunktivitis do onih jako ozbiljnih i teških (zamućenje i ožiljavanje konjunktive i rožnjače, ulceracije rožnjače i keratitis ukoliko se ne leče. Kako bi se obezbedila sigurna dijagnoza telazioze i sprovođenje odgovarajućeg tretmana primarnih problema i komplikacija, neophodno je kontinuirano medicinsko obaveštavanje i svest o ovoj infekciji.

  17. Tratamento farmacológico da dependência do álcool The pharmacologic treatment of the alcohol dependence

    Directory of Open Access Journals (Sweden)

    Luís André Castro

    2004-05-01

    Full Text Available As intervenções farmacológicas podem ter um papel crucial na redução do craving, consumo de álcool e manutenção da abstinência. Este artigo revisa a farmacoterapia para a dependência de álcool com ênfase na naltrexona, dissulfiram e acamprosato. O antagonista opióide naltrexona diminui taxas de recaída, reduz dias de consumo e prolonga períodos de abstinência. Acamprosato restaura a atividade normal dos sistemas glutamato e GABA. Dissulfiram tem demonstrado ser mais efetivo para pacientes que acreditam em sua eficácia e permaneçam aderentes ao tratamento. Ondansetron tem-se mostrado promissor na dependência de álcool de início precoce, mas necessita estudos mais extensivos. Topiramato (até 300 mg/dia foi mais eficaz do que placebo no tratamento da dependência de álcool.The pharmacological intervention can play a crucial role in the reduction of craving and drinking and the maintenance of abstinence. This article reviews pharmacotherapy for alcohol dependence with an emphasis on the naltrexone, dissulfiram and acamprosate. The opioid antagonist naltrexone lowers relapse rate, reduces drinking days and prolongs periods of abstinence. Acamprosate restores the normal activity of glutamate and GABA systems. Disulfiram has been shown to be most effective for patients who believe in its efficacy and remain compliant with the treatment. Ondansetron, has shown promise in the early-onset alcohol dependence but needs more extensive study. Topiramate (up to 300 mg per day was more efficacious than placebo in the treatment of alcohol dependence.

  18. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

    Directory of Open Access Journals (Sweden)

    Robyn D Moir

    2012-08-01

    Full Text Available The ability to store nutrients in lipid droplets (LDs is an ancient function that provides the primary source of metabolic energy during periods of nutrient insufficiency and between meals. The Fat storage-Inducing Transmembrane (FIT proteins are conserved ER-resident proteins that facilitate fat storage by partitioning energy-rich triglycerides into LDs. FIT2, the ancient ortholog of the FIT gene family first identified in mammals has two homologs in Saccharomyces cerevisiae (SCS3 and YFT2 and other fungi of the Saccharomycotina lineage. Despite the coevolution of these genes for more than 170 million years and their divergence from higher eukaryotes, SCS3, YFT2, and the human FIT2 gene retain some common functions: expression of the yeast genes in a human embryonic kidney cell line promotes LD formation, and expression of human FIT2 in yeast rescues the inositol auxotrophy and chemical and genetic phenotypes of strains lacking SCS3. To better understand the function of SCS3 and YFT2, we investigated the chemical sensitivities of strains deleted for either or both genes and identified synthetic genetic interactions against the viable yeast gene-deletion collection. We show that SCS3 and YFT2 have shared and unique functions that connect major biosynthetic processes critical for cell growth. These include lipid metabolism, vesicular trafficking, transcription of phospholipid biosynthetic genes, and protein synthesis. The genetic data indicate that optimal strain fitness requires a balance between phospholipid synthesis and protein synthesis and that deletion of SCS3 and YFT2 impacts a regulatory mechanism that coordinates these processes. Part of this mechanism involves a role for SCS3 in communicating changes in the ER (e.g. due to low inositol to Opi1-regulated transcription of phospholipid biosynthetic genes. We conclude that SCS3 and YFT2 are required for normal ER membrane biosynthesis in response to perturbations in lipid metabolism and ER

  19. Primerjava dveh teoretičnih modelov in teorije zdravstvene nege preko konceptov metaparadigme

    Directory of Open Access Journals (Sweden)

    Dragan Babuder

    2015-06-01

    Full Text Available Uvod: Izbira primernega teoretičnega modela ali teorije zdravstvene nege je osnova za dobro prakso. V Sloveniji uporabljamo teoretični model Virginie Henderson, ki ga v članku primerjamo s teoretičnim modelom Imogene M. King in teorijo zdravstvene nege Hildegard E. Peplau. Metode: Uporabili smo deskriptivno metodo dela s pregledom domače in tuje strokovne ter znanstvene literature. Uporabili smo metodo kritičnega branja javno dostopnih virov, navezujoč se na podatke iz doslej objavljenih knjig, člankov in ostale literature, ki se dotika izbrane teme. Spletno iskanje literature je bilo opravljeno preko vzajemne bibliografsko-kataložne baze podatkov (COBIB.SI ter tujih podatkovnih baz, kot so Jupsline, Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL. Za primerjavo teoretičnih modelov in teorije je bil uporabljen okvir za vrednotenje teoretičnih modelov in teorij po Jacqueline Fawcett. Rezultati: Primerjani teoretična modela in teorija zdravstvene nege opišejo koncepte metaparadigme in odnose med njimi. Koncept zdravstvena nega je najpomembnejši v vseh teoretičnih modelih, cilj vseh pa je zdravje. Vse tri teoretičarke se manj poglabljajo v koncept okolje. Diskusija in zaključek: Na področju uporabe teoretičnih modelov in teorij zdravstvene nege v zadnjih letih je narejenega premalo, medtem ko razvoj zdravstvene nege na drugih področjih hitro napreduje. Medicinske sestre morajo nadaljevati z raziskovanjem in razvojem teoretičnih modelov in teorij.

  20. Evolution of the apomixis transmitting chromosome in Pennisetum

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    Yamada-Akiyama Hitomi

    2011-10-01

    Full Text Available Abstract Background Apomixis is an intriguing trait in plants that results in maternal clones through seed reproduction. Apomixis is an elusive, but potentially revolutionary, trait for plant breeding and hybrid seed production. Recent studies arguing that apomicts are not evolutionary dead ends have generated further interest in the evolution of asexual flowering plants. Results In the present study, we investigate karyotypic variation in a single chromosome responsible for transmitting apomixis, the Apospory-Specific Genomic Region carrier chromosome, in relation to species phylogeny in the genera Pennisetum and Cenchrus. A 1 kb region from the 3' end of the ndhF gene and a 900 bp region from trnL-F were sequenced from 12 apomictic and eight sexual species in the genus Pennisetum and allied genus Cenchrus. An 800 bp region from the Apospory-Specific Genomic Region also was sequenced from the 12 apomicts. Molecular cytological analysis was conducted in sixteen Pennisetum and two Cenchrus species. Our results indicate that the Apospory-Specific Genomic Region is shared by all apomictic species while it is absent from all sexual species or cytotypes. Contrary to our previous observations in Pennisetum squamulatum and Cenchrus ciliaris, retrotransposon sequences of the Opie-2-like family were not closely associated with the Apospory-Specific Genomic Region in all apomictic species, suggesting that they may have been accumulated after the Apospory-Specific Genomic Region originated. Conclusions Given that phylogenetic analysis merged Cenchrus and newly investigated Pennisetum species into a single clade containing a terminal cluster of Cenchrus apomicts, the presumed monophyletic origin of Cenchrus is supported. The Apospory-Specific Genomic Region likely preceded speciation in Cenchrus and its lateral transfer through hybridization and subsequent chromosome repatterning may have contributed to further speciation in the two genera.

  1. Drogadicción, Fármaco-Dependencia o Drogadicción

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    Mario Camacho Pinto

    1994-09-01

    13adrenérgicos y a los histamínicos. Actualmente se admite la existencia de seis grupos de estos receptores opioides en el cerebro, de los cuales uno regula la conducta emocional, otro la percepción del dolor y la analgesia, otro las alucinaciones y la disforia, etc. Aparece claramente definido que el sistema nervioso central y también el periférico, las a encefalinas actúan como neurotransmisores, mientras que las 13endorfinas actúan como neuro-hormonas.

    Se admiten 15 roles a los péptidos opioides endógenos, entre los cuales es conducente citar: percepción del dolor, drogadicción opiácea, liberación de hormonas, memoria, conducta sexual e integración y respuesta al estrés.

    El estudio de los receptores opiáceos realizado por Hiller y asociados, ha demostrado que la más alta densidad del “binding” o ligazón ocurre en el sistema límbico, en las áreas asociadas con la percepción del dolor y/o su modulación (tálamo, sustancia gris periacueductal, cuerno gris dorsal de la médula espinal y también en el nervio vago, la médula suprarrenal, la placentay el tracto gastrointestinal.

    El papel de los receptores opiáceos en el desarrollo de la tolerancia, adicción o abstinencia está en estudio; el conocimiento actual sugiere que su fisiopatología puede estar más relacionada con los efectos posreceptor, a ejemplo de la alteración del ciclo adenosina monofosfato.

    Agentes Neurotóxicos
    Está médicamente demostrado que las drogas estimulantes o euforizantes pueden dar intoxicación, con daño temporal o permanente, por varios mecanismos tales como la inactivación de enzimas y coenzima~ esenciales para los mecanismos de oxidación; alteración de vasos nutrientes; manifestaciones alérgicas o inmunológicas; efectos nocivos sobre los neurotransmisores; alteración en el balance ácido-base o en las concentracions iónicas. Algunos casos llegan a simular entidades neurológicas o a acentuar una pre

  2. Analgesia pós-operatória para procedimentos cirúrgicos ortopédicos de quadril e fêmur: comparação entre bloqueio do compartimento do psoas e bloqueio perivascular inguinal Analgesia postoperatoria para procedimientos quirúrgicos ortopédicos de cadera y fémur: comparación entre bloqueo del compartimiento del psoas y bloqueo perivascular inguinal Postoperative analgesia for orthopedic surgeries of the hip and femur: a comparison between psoas compartment and inguinal paravascular blocks

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Imbelloni

    2006-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Este estudo avaliou a eficácia da injeção única de bupivacaína a 0,25% no compartimento do psoas ou perivascular inguinal por meio do estimulador de nervos periféricos para analgesia pós-operatória em pacientes submetidos a intervenções cirúrgicas ortopédicas. MÉTODO: Cem pacientes receberam bloqueio do plexo lombar através do compartimento do psoas e foram comparados com 100 pacientes que receberam bloqueio do plexo lombar via perivascular inguinal, identificados pelo estimulador de nervos periféricos com a injeção de 40 mL bupivacaína a 0,25% sem epinefrina. A analgesia nos nervos ilioinguinal, genitofemoral, cutâneo femoral lateral, femoral e obturatório foi avaliada 4, 8, 12, 16, 20 e 24 horas após o final da intervenção cirúrgica. A intensidade da dor foi também avaliada no mesmo período. A quantidade de opióides administrada no pós-operatório foi anotada. Em cinco pacientes de cada grupo, estudo radiográfico com contraste não-iônico foi realizado para avaliar a dispersão da solução anestésica. RESULTADOS: Os nervos ilioinguinal, genitofemoral, cutâneo femoral lateral, femoral e obturatório foram bloqueados em 92% dos pacientes no compartimento do psoas versus 62% no bloqueio perivascular inguinal. O bloqueio do plexo lombar reduziu a necessidade de opióides e 42% dos pacientes submetidos ao bloqueio do compartimento do psoas e 36% dos pacientes no bloqueio inguinal não necessitaram de analgésico adicional no pós-operatório. A duração da analgesia foi em torno de 21 horas com bloqueio do compartimento do psoas e 15 horas com bloqueio perivascular inguinal. CONCLUSÕES: O bloqueio do compartimento do psoas e perivascular inguinal é uma excelente técnica para analgesia pós-operatória em intervenções cirúrgicas ortopédicas reduzindo a necessidade de opióides. Este estudo mostrou que a injeção no compartimento do psoas foi mais fácil e mais efetiva no bloqueio

  3. Treatment of restless legs syndrome Tratamento da síndrome das pernas inquietas

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    Tiago Spolador

    2006-12-01

    Full Text Available OBJECTIVE: Restless legs syndrome is a neurological disorder characterized by a desire to move limbs, which is usually only present or worsens during rest or at night. The objective of this article was to review the available literature about pharmacological treatment for this disorder. METHOD: A search of recent literature was undertaken on online databases (Medline, Pubmed, Scielo and Lilacs. RESULTS: 502 articles were retrieved, of which 30 were selected. Dopaminergic agents, anticonvulsants, opioids, benzodiazepines, zolpidem, entacapone and ketamine were all effective on the restless legs syndrome treatment. One study showed that iron was not effective. CONCLUSIONS: Based on few double-blind, randomized, controlled trials, it seems that the best options to treat restless legs syndrome patients are gabapentin and L-dopa associated to its sustained release formulation.OBJETIVO: A síndrome das pernas inquietas é um transtorno neurológico caracterizado por um desejo incontrolável de mover os membros, que comumente está somente presente ou piora ao descanso ou à noite. O objetivo do trabalho foi a revisão da literatura disponível sobre o tratamento farmacológico para a síndrome das pernas inquietas. MÉTODO: Pesquisa da literatura recente realizada em bases de dados eletrônicas (Medline, Pubmed, Scielo e Lilacs. RESULTADOS: Quinhentos e dois artigos foram encontrados, dos quais 30 foram selecionados. Os agentes dopaminérgicos, os anticonvulsantes, os opióides, os benzodiazepínicos, o zolpidem, o entacapone e a ketamina foram eficazes no tratamento da síndrome das pernas inquietas. Um estudo mostrou que o ferro não foi eficaz. CONCLUSÕES: Baseado nos poucos estudos duplo-cegos, randomizados e controlados, parece que as melhores opções para tratar os pacientes com síndrome das pernas inquietas são a gabapentina e L-dopa associada à sua formulação de liberação lenta.

  4. Sufentanil intratecal para revascularização do miocárdio

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    Caetano Nigro Neto

    2014-04-01

    Full Text Available Contexto: pacientes de cirurgia cardíaca submetidos a revascularização do miocárdio com circulação extracorpórea. Objetivo: avaliar o efeito hemodinâmico da adição de sufentanil intratecal para anestesia geral. Desenho: estudo prospectivo, randômico e aberto, após aprovação do Comitê de Ética em Pesquisa. Cenário: estudo monocêntrico feito no Instituto Dante Pazzanese de Cardiologia, São Paulo, Brasil. Pacientes: foram submetidos à revascularização eletiva 40 pacientes de ambos os sexos que assinaram o termo de consentimento informado. Critérios de exclusão: doença renal crônica, procedimentos de emergência, reoperações, contraindicação para raquianestesia, fração de ejeção do ventrículo esquerdo inferior a 40%, índice de massa corporal acima de 32 kg/m2 e uso de nitroglicerina. Intervenções: os pacientes foram randomizados para receber (ou não 1μg/kg de sufentanil intratecal. Anestesia foi induzida e mantida com infusão contínua de sevoflurano e remifentanil. Principais medidas de desfecho: variáveis hemodinâmicas, níveis sanguíneos de troponina I cardíaca, peptídeo natriurético do tipo B, interleucina-6 e fator de necrose tumoral alfa durante e após a cirurgia. Resultados: os pacientes do grupo sufentanil precisaram de menos suporte inotrópico com dopamina, comparados aos do grupo controle (9,5% vs 58%, p = 0,001, e menos aumentos de doses de remifentanil (62% vs 100%, p = 0,004. Os dados hemodinâmicos em oito intervalos de tempo diferentes e os dados bioquímicos não apresentaram diferenças entre os grupos. Conclusões: os pacientes que receberam sufentanil intratecal apresentaram uma estabilidade hemodinâmica maior, como sugerido pelo suporte inotrópico reduzido, e menos ajustes nas doses intravenosas de opiáceos.

  5. Safety report for the independent CO{sub 2} loop for cooling the samples irradiated in the vertical experimental channels of the RA reactor; Izvestaj o sigurnosti za nezavisno kolo CO{sub 2} za hladjenje uzoraka ozracenih u vertikalnim eksperimentalnim kanalima reaktora RA

    Energy Technology Data Exchange (ETDEWEB)

    Pavlovic, A; Zivkovic, S; Milosevic, M; Strugar, P [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1969-07-01

    Independent CO{sub 2} loop was designed for cooling the samples irradiated in the vertical experimental channels in the region of heavy water or in the graphite reflector. It is considered as a significant improvement of the RA reactor experimental possibilities. Six 'heads' are placed in vertical experimental channels and connected in parallel with the outer loop which contains out-of-reactor equipment. It is planned to irradiate samples in the 'heads' of the loop for the needs of Hot laboratory and Laboratory for reactor materials. Heat generated during sample irradiation is removed by CO{sub 2} circulation. This report contains detailed description of the main loop, auxiliary systems, calculation results of anti reactivity and activation of construction materials of the low-temperature CO{sub 2} loop. A separate chapter is devoted to control and regulation of temperature and pressure. Testing of the fundamental parameters of the coolant loop showed that it could fulfill more demanding tasks than designed by the project. Annex of this report includes results of leak testing for the loop 'heads' in vertical experimental channels VEK-6 and VEK-8 by helium leak detector. [Serbo-Croat] Nezavisno kolo CO{sub 2} namenjeno je za hladjenje uzoraka ozracivanih u VEK reaktora u zoni teske vode i u zoni grafita, i predstavlja znacajan doprinos povecanju eksperimentalnih mogucnosti reaktora RA. Sest 'glava' je postavljeno u vertikalne eksperimentalne kanale i paralelno vezano na spoljno kolo koje sadrzi vanreaktorsku opremu. U glavama petlje se predvidja ozracivanje raznovrsnih uzoraka materijala za potrebe Laboratorije za visoku aktivnost i Laboratorije za reaktorske materijale. Toplota koja se generise prilikom ozracivanja uzoraka odvodi se cirkulacijom CO{sub 2}. Ovaj izvestaj sadrzi detaljan opis: glavnog kola, pomocnih sistema; rezultate proracuna antireaktivnosti i aktivacije konstrukcionih elemenata glave niskotemperaturne petlje CO{sub 2}. Posebno poglavlje posveceno

  6. Influence of temperature on the micro-and nano-structures of experimental PBMR TRISO coated particles: A comparative study - HTR2008-58189

    International Nuclear Information System (INIS)

    Van Rooyen, I. J.; Neethling, J. H.; Mahlangu, J.

    2008-01-01

    The PBMR fuel consists of TRISO Coated Particles (CPs) in a graphite matrix. The three layer system, IPyC-SIC-OPyC, forms the primary barrier to fission product release, with the SiC layer acting as the main pressure boundary of the particle. The containment of fission products inside the CPs is however a function of the operating temperature and microstructure of the SiC layer. During accident conditions, the CPs will reach higher temperatures than normal operating conditions. The Fuel Design Dept. of PBMR is therefore investigating various characteristics of the SiC layer, especially nano characteristics at variant conditions. The integrity of the interface between the SiC and Inner PyC layers is also important for fission product retention and therefore interesting TEM images of this region of the experimental PBMR TRISO particles will be shown. Transmission electron microscope (TEM) images of the microstructure of TRISO coated particles of three different experimental batches after annealing will be discussed. Particles annealed at 1980 deg. C for 1 hour revealed that the inner PyC layer de-bonded from the SiC layer. Changes observed in the diffraction rings are evidence that the PyC structure is becoming organized or anisotropic. The SiC layer, on the other hand, did not show any changes as a result of annealing. Only the cubic 3C-SiC phase was observed for a limited number of grains analyzed. The nano hardness and elasticity measurements of the three test batches were done using a CSM Nano Hardness Tester. These results are compared to indicate possible differences between the 1 hour and 5 hour annealing time as a function of annealing temperature from 1000 deg. C to 1980 deg. C. The variation of hardness and elasticity as a function of temperature for the three experimental batches are identified and discussed. This preliminary TEM investigation and nano hardness measurements have contributed new knowledge about the effect of high temperature annealing on

  7. Intelligent plasma operation and control system for HL-2M

    International Nuclear Information System (INIS)

    Xia, F.; Chen, L.Y.; Wang, C.; Zhang, G.; Song, X.M.; Song, X.; Pan, L.; Zhao, L.; Pan, W.; Lan, J.T.

    2015-01-01

    Full text of publication follows. The Intelligent Plasma Operation and Control System (IPOCS) for HL-2M is under construction based on the current actual situation of HL-2A control system in SWIP. The purpose of IPOCS is to replace the routine processes before, during and post discharge with the automatic process algorithms and give various information, for example, status, warning, reason, instruction, suggestion, physics phenomenon etc. to staff who can access the intranet. In this case, the core research objectives can be focused on and the related operations can be carried out referring to the information. The ultimate goal of IPOCS is to improve the efficiency of plant operation and control and physics research for HL-2M and for the fusion reactor in the future. There are three layers in IPOCS, which are named the information collection layer, the data processing layer and the presentation layer respectively. Information collection layer consists of data acquisition system, EPICS system, Audio and Video system, discharge scheduling system, data storage system etc. All raw data are collected and stored in this layer. The data processing layer is the core of IPOCS. Most algorithms are executed here. The basic computation platform is based on cluster (56 cores at present) and Parallel Computing Toolbox provided by Matlab. The physics database for SWIP based on HDF5 and offline EFIT also locate at this layer. All the operations can be finished during the time interval between two shots. The last layer is to present the information from the former two layers. The typical hardware including the large display screen system in the control room, the voice broadcasting system, personal monitors and smart phones, etc.. Several applications has being developed such as Control System Studio (CSS) in SWIP version, WebOPI, Automatic Alarm Display system and so on. IPOCS for HL-2M is at the very beginning phase at present. With more and more systems and algorithms got

  8. Influência do grupo de pares e uso de drogas ilícitas entre adolescentes brasileiros: um estudo transversal

    Directory of Open Access Journals (Sweden)

    Kelly Oliva Jorge

    2018-03-01

    Full Text Available O estudo teve como objetivo examinar o uso de drogas ilícitas e as associações com fatores socioeconômicos e influência do grupo de pares entre adolescentes brasileiros de 15 a 19 anos de idade. Foi adotada uma amostra de clusters em dois estágios, com a seleção aleatória de escolas públicas e privadas entre os nove distritos administrativos de uma capital de estado, e a seleção aleatória de turmas em cada escola. A variável de desfecho foi o uso de drogas ilícitas, medido pela seguinte pergunta: “Você já usou drogas ilícitas (maconha, inalantes, hipnóticos, cocaína/crack, alucinógenos, anfetaminas e/ou opióides alguma vez na vida?”. Os grupos de pares foram classificados como: escola, família, atividades religiosas e esportes/cultura. O nível socioeconômico foi avaliado com o Índice de Vulnerabilidade em Saúde (IVS baseado em área. Foram analisados os dados de 91 adolescentes com o teste do qui-quadrado e regressão logística. A proporção global de uso de drogas ilícitas foi 15,2%. A heterogeneidade por gênero dentro de grupos (OR = 3,14; IC95%: 1,63-6,06, amizades baseadas em religião (OR = 0,36; IC95%: 0,17-0,75 e amizades baseadas em esportes/cultura (OR = 0,44; IC95%: 0,22-0,87 permaneceram associadas significativamente com o uso de drogas ilícitas. Os adolescentes que residiam em áreas menos vulneráveis mostraram maior probabilidade de uso de drogas ilícitas, quando comparados aos jovens em áreas mais vulneráveis. As amizades baseadas em religião e esportes/cultura parecem ter um efeito protetor contra o uso de drogas ilícitas. A heterogeneidade de gênero dentro de grupos e a residência em áreas menos vulneráveis aumentaram as chances de uso de drogas ilícitas por adolescentes.

  9. A COMPARATIVE STUDY OF FUNCTIONAL OUTCOMES OF FRACTURE SHAFT HUMERUS IN ADULTS TREATED WITH DYNAMIC COMPRESSION PLATING AND INTERLOCKING NAILING

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    Nagesh Desai

    2015-02-01

    Full Text Available INTRODUCTION: Opti m al m ethod of hu m eral shaft f r acture f i xation remains in debate till date. Two techniq u es under study include i n tra m edullary nailing and dyna m ic co m pression plate fixation. Plating provides satisfactory results but requires extensive dissection and m eticulous radial nerve protection. Theoretical advantage of intra m ed u llary nailing included less invasive surgery, undisturbed fractu r e hemato m a and use of load sharing device support. Purpose of this study is to co m p are o u tco m es of each m ethod of fixation for fracture shaft of humerus. MATERIALS AND METHODS: P atients with diaphyseal fractures of the hu m erus were divided in two groups of 20 treated with dynam i c co m pression plate or w i th i n tra m edullary interlocking nail. Postoperatively both groups received sa m e type of physiotherapy. They were followed up regularly . T i me taken for radiological union in two groups was co m pared. After satisfactory radiological un i on, functional out c o m e was assessed by “Disabilities of Hand, Shoulder and Elbow (DASH Questionnaire”. RESULTS: F unctional outco m e was better in DCP group co m pared to int e rloc ki ng nailing group which was statistically significant ( P = 0.062. Rate of healing was marginally better in DCP group as compared to I.M nail. CONCLUSION: W e are of opi n i on that when s u r ge r y is opted as a c h oice of treat m ent, both modalities of treat m ent i.e. dyn a m i c co m pression plating and interlocking nailing are good as far as union of fracture is concerned, but considering number of co m plications and functional outco m e, we opine that d y na m i c co m p ression plating o f f ers bett e r result than anteg r ade i n te r l ocking nailing with respect to pain and function of shoulder joint

  10. Prevención del suicidio en médicos

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    José Carlos Mingote Adán

    2013-06-01

    Full Text Available Se sabe que la tasa de suicidio en médicos es mayor que en la población general. La salud de los médicos ha recibido escasa atención de sus colegas, a pesar de la considerable y creciente evidencia de que la morbilidad es alta en la profesión. Cuidar de otras personas genera estrés en los cuidadores. El estrés por la incertidumbre clínica y el temor al fracaso son rasgos importantes de la cultura médica. La paradoja es que el cuidado de los pacientes genera estrés pero es también la fuente de gratificación más importante del médico. Se sabe que aquellos que cuidan de los demás a menudo tienen grandes dificultades para buscar y recibir ayuda para ellos mismos. Las tasas de suicidio de los médicos en Estados Unidos, Inglaterra y otros países son más altas que las de la población general y las de otras profesiones. La tasa de suicidio de los médicos es ligeramente mayor que la de la población general, mientras que la de las médicas es claramente superior. Esta tendencia es más pronunciada entre psiquiatras y anestesistas. Los médicos tienen unas necesidades asistenciales específicas por sufrir elevados niveles de alcoholismo, dependencia de drogas, rupturas matrimoniales, enfermedad mental y suicidio. La automedicación es muy frecuente entre los médicos, en especial con hipnóticos, antidepresivos y analgésicos opiáceos. Muchas de estas dificultades están relacionadas con el estrés, elevada responsabilidad y tiempo insuficiente para trabajar y vivir conciliando las demandas laborales y familiares. Muchos médicos tienen grandes dificultades para discutir sus problemas con los colegas y se tratan a ellos mismos, de forma notablemente peligrosa. El fácil acceso de los médicos a las drogas implica que el abuso de drogas sea un riesgo ocupacional potencial de hombres y mujeres.

  11. The Festuco-Brometea Grasslands on Sandstone and Marl-Clay-Sandstone Substrata in Tuscany (Northern-Central Italy

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    Foggi Bruno

    2014-06-01

    Full Text Available Travišča v katerih prevladujeta vrsti Bromus erectus in/ali Brachypodium rupestre pokrivajo velike površine na podlagi iz peščenjaka in laporasto-glinastega peščenjaka (apnenec je izključen na Apeninih in območju pred njimi med provincama Pistoia in Arezzo (Toskana, srednja Italija. Naša raziskava je bila osredotočena na 71 neobjavljenih in 45 objavljenih vegetacijskih popisov iz Toskane in sosednjih območij. Originalni popisi opisujejo asociacije Astragalo monspessulani-Brometum erecti, Centaureo bracteatae-Brometum erecti in Ononido masquillerii-Brometum erecti. Popise smo obdelali z multivariatno analizo s katero smo zaznali 9 skupin. Konsistenstnost skupin smo preverili s povprečjem NMDS proti Ellenberg/Pignatti indikatorskim vrednostim in CCA proti horotipom in rastnim oblikam. Diagnostične vrste posameznih skupin smo določili z navezanostjo vrst, ki temelji na φ koeficientu asociacije. Z analizo smo podatkovni niz razdelili na dva klastra; prvi (A vključuje nekaj popisov termofilne cenoze z nižje nadmorske višine, ki jih opišemo kot prehod med submediteranskim aspektom razreda Festuco-Brometea in drugih mediteranskih zeliščnih in grmiščnih razredov; drugi klaster (B pa vključuje večino podatkovnega niza in ga lahko členimo na pionirske, mezokserofilne (skupini B1 in B2a in mezofilne združbe (skupina B2b. Popise klastrov B1 in B2a uvrščamo v asociacijo Coronillo minimae-Astragaletum monspessulanii in tri druge skupine: združba Plantago argentea-Carex caryophyllea, združba Tragopogon samaritani-Bromus erectus in Festuco trachyphyllae-Brometum erecti ass. nova. Mezofilna skupina (B2b vključuje popise asociacij Centaureo bracteatae-Brometum erecti in Ononido masquillerii- Brometum erecti, skupaj z delno spremenjeno združbo. Zaradi majhnih razlik v florističnem, ekološkem in horološkem pogledu med temi traviščnimi tipi predlagamo, da jih obravnavamo kot tri subasociacije Centaureo bracteatae

  12. Complementos alimenticios funcionales: péptidos antihipertensivos procedentes de la leche

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    Gómez Sala B

    2011-09-01

    Full Text Available Los complementos alimenticios representan una importante fuente de nutrientes esenciales y otros elementos. Últimamente, se está produciendo un aumento de su consumo relacionado con la importancia que está adquiriendo el autocuidado de la salud, donde el farmacéutico juega un importante papel. Dentro de esta categoría de sustancias han aparecido recientemente los péptidos bioactivos. Estos péptidos son secuencias de aminoácidos de pequeño tamaño, inactivas dentro de la proteína intacta, pero que pueden ser liberados durante la digestión del alimento en el organismo o por un procesado previo del mismo. Tienen efectos beneficiosos en diversos casos y pueden influir positivamente en la salud de la población. Algunas actividades que han demostrado tener son: antihipertensiva, opiácea, antioxidante, quelante de minerales o inmunomoduladora. De entre los diferentes grupos de péptidos bioactivos, los péptidos antihipertensivos están recibiendo una especial atención debido a la frecuencia de la hipertensión arterial en la población mundial. Estos péptidos obtenidos por fermentación o hidrólisis enzimática han demostrado su actividad antihipertensiva como inhibidores de la enzima convertidora de angiotensina, mediante ensayos in vitro e in vivo en animales de experimentación en pruebas agudas, crónicas y toxicológicas, así como en ensayos clínicos en humanos. Son unos productos de probada seguridad y eficacia. Su aparición como complementos alimenticios permite al farmacéutico tener un recurso terapéutico, que no es de prescripción, para su indicación en aquellos casos en los que se detecten valores de presión arterial que sin llegar a la hipertensión sean susceptibles de una intervención farmacéutica.

  13. Diario de una vida que no pudo ser: Estudio fenomenológico sobre la drogodependencia Diary of a life that could not be: A phenomenological stugy of drug addiciton

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    Juan M. Leyva-Moral

    2007-09-01

    Full Text Available Justificación: El profesional de enfermería juega un papel crucial en la atención a las personas drogodependientes ya que son la puerta de entrada al conocimiento de las familias, del barrio y de los jóvenes. Conocer dicha realidad puede resultar útil para diseñar estrategias de promoción de la salud así como campañas de prevención. Objetivo: El objetivo de este estudio es conocer el significado que la persona drogodependiente atribuye a su drogadicción. Diseño: Estudio cualitativo con un enfoque fenomenológico. Metodología: Carmen es una mujer de 41 años, adicta a opiáceos desde los 17 años, ingresada en la Unidad de Patología Dual de un centro neuropsiquiátrico en Barcelona, durante el mes de septiembre de 2006. Para la recogida de datos se utilizó un diario semi-estructurado. Resultados: Se describe la drogadicción como algo negativo, responsable de sentimientos de tristeza, fracaso, destrucción y un gran deterioro emocional secundario a los sentimientos de culpabilidad. La participante describe este fenómeno en tres fases: uso-abuso-adicción. Conclusión: El diario elaborado por Carmen permite conocer el significado de la drogadicción y del internamiento para su deshabituación.Justification: Nurses play a crutial role in taking care of people with drug-abuse problems since they know the reality of families, the neighbourhood and the youths. Knowing this reality can be useful to design strategies of health promotion as well as prevention campaigns. Aim: The main aim of this study is to ascertain the meaning that a drug user gives to her situation with substance misuse. Design: Qualitative study based with a phenomenological approach. Methodology: Carmen is a 41 years old woman, addict to opioids since she was 17. Data was collected using a diary while she was admitted in a Dual Pathology Unit in a neuro-psichiatric hospital in Barcelona during September 2006. Results: Drug addiction is drescribed by the participant

  14. HIGH-TEMPERATURE SAFETY TESTING OF IRRADIATED AGR-1 TRISO FUEL

    Energy Technology Data Exchange (ETDEWEB)

    Stempien, John D.; Demkowicz, Paul A.; Reber, Edward L.; Chrisensen, Cad L.

    2016-11-01

    primary goals. First, the test was intended to assess the retention of fission products in loose kernels without the effects of the other TRISO layers (buffer, IPyC, SiC, and OPyC) or the graphitic matrix material comprising the compact. Second, this test served as an evaluation of the FACS fission product condensation plate collection efficiency.

  15. Acceptance Test Data for the AGR-5/6/7 Irradiation Test Fuel Composite Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-05-01

    Coated particle composite J52R-16-98005 was produced by Babcock and Wilcox Technologies (BWXT) as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). This composite was comprised of four coated particle fuel batches J52O-16-93165B (26%), 93168B (26%), 93169B (24%), and 93170B (24%), chosen based on the Quality Control (QC) data acquired for each individual candidate AGR-5/6/7 batch. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT Lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A). Secondary upgrading by sieving was performed on the A-designated batches to remove particles with missing or very-thin buffer layers that were identified during previous analysis of the individual batches for defective IPyC, as reported in the acceptance test data report for the AGR-5/6/7 production batches [Hunn et al. 2017]. The additionally-upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93165B).

  16. X-ray Analysis of Defects and Anomalies in AGR-5/6/7 TRISO Particles

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-06-01

    Coated particle fuel batches J52O-16-93164, 93165, 93166, 93168, 93169, 93170, and 93172 were produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), or may be used for other tests. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.4%-enriched uranium carbide and uranium oxide (UCO), with the exception of Batch 93164, which used similar kernels from BWXT lot J52L-16-69316. The TRISO-coatings consisted of a ~50% dense carbon buffer layer with 100-μmnominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. Each coated particle batch was sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batch was designated by appending the letter A to the end of the batch number (e.g., 93164A). Secondary upgrading by sieving was performed on the upgraded batches to remove specific anomalies identified during analysis for Defective IPyC, and the upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93165B). Following this secondary upgrading, coated particle composite J52R-16-98005 was produced by BWXT as fuel for the AGR Program’s AGR-5/6/7 irradiation test in the INL ATR. This composite was comprised of coated particle fuel batches J52O-16-93165B, 93168B, 93169B, and 93170B.

  17. A enfermagem na avaliação e controle da dor pós-operatória

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    Viviane Silvestre de Souza

    2018-02-01

    Full Text Available A dor é o quinto sinal vital que deve ser registrado ao mesmo tempo e no mesmo ambiente clínico em que também são avaliados os outros sinais. Uma avaliação segura e eficaz do paciente, na qual alterações endócrinas e metabólicas decorrentes do trauma anestésico-cirúrgico sejam consideradas e, ainda, a criação de padrões e critérios de avaliação para a assistência prestada ao paciente neste período e avaliação dos mesmos. O controle da dor pós-operatória envolve basicamente o uso de AINEs, opióides, por diversas vias e métodos, uso de meios físicos e intervenções de natureza comportamental cognitiva, como técnicas educativas, de relaxamento, distração e imaginação dirigida entre outras. O presente estudo foi desenvolvido através de pesquisas bibliográfica indexados nas bases de dados: Scielo e Lilacs, com os seguintes descritores: Dor, Pós-operatório, Avaliação, Controle e Enfermagem. O objetivo deste estudo é descrever sobre a atuação da enfermagem na avaliação e controle da dor pós-operatória. É função da enfermagem implementar a terapêutica adequada visando a prevenção e o alívio da dor, responsabilizando-se pela avaliação da mesma no período pós-operatório visando a promoção do conforto ao paciente com o alivio da dor.. Descritores: Dor; Pós-operatório; Avaliação; Controle; Enfermagem.

  18. Transtorno de estresse pós-traumático em pacientes de unidade de terapia intensiva Post-traumatic stress disorder in intensive care unit patients

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    Andrea Vannini Santesso Caiuby

    2010-03-01

    Full Text Available O transtorno de estresse pós-traumático tem sido descrito em pacientes após tratamento em unidade de terapia intensiva. O objetivo foi revisar estudos sobre os aspectos psicológicos e as intervenções terapêuticas destes pacientes após internação em unidade de terapia intensiva. Trinta e oito artigos foram incluídos. A prevalência de transtorno de estresse pós-traumático variou de 17% a 30% e a incidência de 14% a 24%. Os fatores de risco foram: história prévia de ansiedade, depressão ou pânico, ter memórias traumáticas ilusórias (memórias derivadas de formações psíquicas como sonho e delirium, tempo de ventilação mecânica, experiências estressantes, crenças e comportamentos de característica depressiva. Doses altas de opióides, sintomas na retirada da sedação ou analgesia e o uso de lorazepam foram relacionados ao aumento de delirium e de memória ilusória. A sintomatologia do transtorno pode ser reduzida com a administração de hidrocortisona, com a interrupção diária da sedação e não foram encontrados estudos de efetividade de intervenção psicológica.Post-traumatic stress disorder has been detected in patients after treatment in intensive care unit. The main goal of this study is to review the psychological aspects and therapeutic interventions on those patients after their treatment on intensive care unit. Thirty eight articles have been included. The prevalence of post-traumatic stress disorder has varied from 17% up to 30% and the incidence from 14% to 24%. The risk factors were: previous anxiety historic, depression or panic, having delusional traumatic memories (derived from psychic formations as dreams and delirium, belief effects, depressive behavior, stressing experiences and mechanical ventilation. High doses of opiates, symptoms caused by sedation or analgesia reduction and the use of lorazepam were related with the increase of delirium and delusional memory. The disorder sintomatology

  19. Cognición social en el abuso de sustancias. Una revisión narrativa

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    Jessica Zapata Téllez

    2017-06-01

    Full Text Available Introducción: la Cognición Social (CS es el conjunto de procesos neurobiológicos, psicológicos y sociales que permiten percibir, reconocer y evaluar una situación social con el objetivo de generar la respuesta conductual más apropiada para cada contexto. Se integra por cinco dominios: Teoría de la Mente, Procesamiento Emocional, Estilo Atribucional, Percepción Social y Conocimiento Social. Al hablar del abuso de sustancias, la CS cobra relevancia por su implicación en el pronóstico terapéutico y la reinserción social de los usuarios en rehabilitación. Objetivo: explorar la información existente dentro de la literatura científica, en torno al funcionamiento de los dominios de CS en abusadores de sustancias. Metodo: se realizó una búsqueda de información en bases de datos digitales. Se consideraron investigaciones cuasi y experimentales, publicadas a partir del año 2000, que incluyeran la evaluación de al menos un dominio de la CS en participantes con abuso o dependencia de sustancias. Resultados: se encontraron reportes de investigación que documentan alteraciones en los dominios de Procesamiento Emocional y Teoría de la Mente, en casos de abuso de alcohol, cannabis, metanfetaminas, cocaína y opiáceos; las alteraciones tienden a variar dependiendo de la sustancia y la severidad de consumo. No se encontraron documentos que evidencien el funcionamiento de los dominios Sesgo Atribucional, Percepción Social ni Conocimiento Social. Discusión y conclusiones: resulta aventurado señalar la existencia de un déficit de CS y sus dominios para cada sustancia en específico; los estudios son aún escasos, existe variabilidad respecto a los instrumentos empleados y falta considerar otras variables clínicas que pudieran moderar o modificar la asociación entre los dominios de la CS y el consumo abusivo de sustancias.

  20. SU-E-T-25: A Dosimetric Comparison of Three-Dimension Conformal and Intensity-Modulated Radiation Therapy in Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo, N; Maneru, F; Fuentemilla, N; Olasolo, J; Gracia, M; Pellejero, S; Bragado, L; Lozares, S; Miquelez, S; Martin, M [Complejo Hospitalario de Navarra, Pamplona, Navarra (Spain)

    2015-06-15

    Purpose: dosimetric comparison of 3DCRT and IMRT in 9 esophageal cancer. The aim of this paper is to know which of these two techniques is dosimetrically more favorable dosimetrically at both the CTV coverage and dose obtained in the relevant organs at risk, in this case, lungs and heart, as the spinal cord received in all cases below 45 Gy. Methods: we chose 9 patients from our center (CHN) with the same type of esophageal cancer and in which the prescribed dose was the same, 54 Gy. For these treatments we have used the same fields and the same angles (AP (0 °), OPD (225°–240°) and OPI (125°–135°)).All plans have been implemented using Eclipse (version 11.0) with AAA( Analytical Anisotropic Algorithm )(Version 11.0.31). Results: To analyze the coverage of the CTV, we have evaluated the D99% and found that the average dose received by 99% of CTV with IMRT is 53.8 ± 0.4 Gy (99.6% of the prescribed dose) and the mean value obtained with 3DCRT is 52.3 ± 0.6 Gy (96.8% of the prescribed dose).The last data analyzed was the D2% of PTV, a fact that gives us information on the maximum dose received by our PTV. D2% of the PTV for IMRT planning is 55.4 ± 0.4 Gy (102.6% of the prescribed dose) and with 3DCRT is 56.8 ± 0.7 Gy (105.2% of the prescribed dose).All parameters analyzed at risk organs (V30, V40, V45 and V50 for the case of heart and V5, V10, V15 and V20 for the case of the lungs) provide us irradiated volume percentages lower in IMRT than 3DCRT. Conclusion: IMRT provides a considerable improvement in the coverage of the CTV and the doses to organs at risk.

  1. Cleptomania: características clínicas e tratamento Kleptomania: clinical characteristics and treatment

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    Jon E Grant

    2008-05-01

    Full Text Available OBJETIVOS: A cleptomania, um transtorno incapacitante do controle dos impulsos, caracteriza-se pelo furto repetitivo e incontrolável de itens que são de pequena utilidade para a pessoa acometida por esse transtorno. Apesar de seu histórico relativamente longo, a cleptomania continua sendo pouco entendida pelo público geral, pelos clínicos e pelos que dela sofrem. MÉTODO: Este artigo revisa a literatura sobre o que se sabe a respeito das características clínicas, histórico familiar, neurobiologia e opções de tratamento para indivíduos com cleptomania. RESULTADOS: A cleptomania geralmente tem seu início no final da adolescência ou no início da vida adulta, e parece ser mais comum em mulheres. A comorbidade psiquiátrica ao longo da vida com outros transtornos de controle de impulsos (20-46%, de uso de substâncias (23-50% e de humor (45-100% é freqüente. Indivíduos com cleptomania sofrem de prejuízo significativo em sua capacidade de funcionamento social e ocupacional. A cleptomania pode responder ao tratamento com terapia cognitivo-comportamental e com várias farmacoterapias (lítio, antiepilépticos e antagonistas de opióides. CONCLUSÕES: A cleptomania é um transtorno incapacitante que resulta em uma vergonha intensa, bem como problemas legais, sociais, familiares e ocupacionais. São necessários estudos de tratamento em ampla escala.OBJECTIVES: Kleptomania, a disabling impulse control disorder, is characterized by the repetitive and uncontrollable theft of items that are of little use to the afflicted person. Despite its relatively long history, kleptomania remains poorly understood to the general public, clinicians, and sufferers. METHOD: This article reviews the literature for what is known about the clinical characteristics, family history, neurobiology, and treatment options for individuals with kleptomania. RESULTS: Kleptomania generally has its onset in late adolescence or early adulthood and appears to be more

  2. Los determinantes institucionales de las patentes del Consejo Superior de Investigaciones Científicas: una aproximación histórica y una dialéctica con la Economía

    Directory of Open Access Journals (Sweden)

    Azagra Caro, Joaquín M.

    2009-06-01

    Full Text Available To date, normative studies on the generation of public patents have focused on universities. This paper extends the analysis to public research organisations (PRO. From both a historic and economic standpoint, and via the interpretation of three institutional factors (the change in the political and legal background, the dominance of certain areas of science over others, and the increase in technological cooperation, the reasons moving the Consejo Superior de Investigaciones Científicas (CSIC; the Spanish Research Council to file patents were examined. The impact of these quantified factors on patenting was examined from 1987 to the present. The institutional framework of bodies such as the CSIC was found to favour a patenting culture. The historical approach adopted defined homogeneous analytical periods and guided the interpretation of the results and their effects over time, while the economic approach allowed some of the relationships seen to be quantified and questioned the validity of merely descriptive classifications (e.g., scientific areas according to number of patents.

    Hasta la fecha los estudios normativos sobre el origen de patentes públicas han estado centrados en las patentes universitarias. Con este artículo extendemos el análisis a las patentes generadas en los organismos públicos de investigación (OPI. Desde una doble perspectiva, la histórica y la económica, y a través de la interpretación de tres factores institucionales (evolución de los cambios políticos y legales, primacía de unas áreas científicas sobre otras y aumento de la cooperación tecnológica se analiza qué lleva al Consejo Superior de Investigaciones Científicas (CSIC a patentar. Para el último período, desde 1987, hemos cuantificado el impacto de estos factores en las patentes. Hemos concluido que el marco institucional resulta eficaz en un organismo como el CSIC para crear una cultura favorable a la patente. La aproximación hist

  3. Correlation Relationship of Performance Shaping Factors (PSFs) for Human Reliability Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bheka, M. Khumalo; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2014-10-15

    between PSFs using correlation analysis and identify patterns in the PSFs using Principal Factor Analysis (PFA). The study is specifically based on Operational Performance Information Systems (OPIS) database. This study was conducted to determine causal relationships between PSFs and also find sets of PSFs (error forcing context) which contribute more to human error probabilities. These goals were achieved using correlation and principal factor analysis.

  4. Uso não-médico de medicamentos psicoativos entre escolares do ensino fundamental e médio no Sul do Brasil Non-medical use of psychoactive medicines among elementary and high school students in Southern Brazil

    Directory of Open Access Journals (Sweden)

    Tatiane da Silva Dal Pizzol

    2006-01-01

    Full Text Available O objetivo do presente estudo é investigar a prevalência de uso não-médico de medicamentos entre escolares da rede de ensino público e privado de Passo Fundo, Rio Grande do Sul, Brasil, e sua distribuição em relação a fatores sócio-demográficos. Por meio de um delineamento transversal, foi aplicado um questionário de autopreenchimento a 5.057 estudantes a partir da quinta série do ensino fundamental até o terceiro ano do ensino médio. O questionário continha perguntas sobre o uso, sem receita médica, de anfetamínicos, ansiolíticos, barbitúricos, anticolinérgicos, opiáceos, orexígenos e anabolizantes. Da amostra, 7,7% consumiram ansiolíticos alguma vez na vida, 6,4% consumiram anfetamínicos, 2,2%, anabolizantes, e 1,1%, barbitúricos. Estudantes do sexo feminino apresentaram maior consumo de ansiolíticos e anfetamínicos, enquanto que o consumo de anabolizantes foi maior no sexo masculino. O padrão de consumo de medicamentos psicoativos é semelhante ao observado em adultos, sugerindo a necessidade de inclusão de crianças e adolescentes nas campanhas educativas para prevenção do uso indevido de medicamentos.The objective of this study is to assess the prevalence of and risk factors for the non-medical use of psychoactive medicines among students at public and private schools of Passo Fundo, Southern Brazil. A cross-sectional study was carried out using a questionnaire administered to 5,057 students from the 5th grade of elementary school to the 3rd year of high school. The questionnaire contained questions about the use of amphetamines, tranquilizers, barbiturates, anticholinergics, opioids, appetite stimulants, and anabolic steroids. Of the sample total, 7.7% had consumed tranquilizers sometime during their lives, 6.4% had used amphetamines, 2.2% had used anabolic steroids, and 1.1% had used barbiturates. Female students reported significantly greater consumption of tranquilizers and amphetamines, while anabolic

  5. Gruźlica płuc u 27-letniej kobiety

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    Kamilla Tymińska

    2009-09-01

    Full Text Available Rozstrzenie oskrzeli to utrwalone, nieodwracalne, różnokształtne nieprawidłowe rozszerzenia oskrzeli – oskrzela są pogrubione i poszerzone oraz mają zmiany zapalne. U około 50% chorych przyczyna rozstrzeni oskrzeli pozostaje nieznana. Mukowiscydoza jest chorobą uwarunkowaną genetycznie, dziedziczoną autosomalnie recesywnie. W większości jej przypadków dochodzi do zajęcia układów pokarmowego i oddechowego. Chlamydophila pneumoniae to bakteria przenoszona drogą kropelkową, wywołująca głównie ostre infekcje górnych i dolnych dróg oddechowych. Następstwem zakażenia mogą być uszkodzenie nabłonka rzęskowego w oskrzelach i zmiany sprzyjające rozwojowi astmy, nawracających katarów nosa, przewlekłego zapalenia gardła i zapalenia zatok. Według raportu WHO w roku 2006 zanotowano 9,2 miliona nowo rozpoznanych przypadków gruźlicy, z czego 7,7% dotyczyło chorych zakażonych wirusem HIV. Głównym celem światowego programu kontroli gruźlicy jest zmniejszenie zachorowalności i umieralności z powodu tej choroby do 2015 roku. DOTS (Directly Observed Treatment Short-course, czyli strategię krótkich kursów nadzorowanego leczenia, uważa się za najbardziej wydajną ekonomicznie w zwalczaniu gruźlicy. Opis przypadku dotyczy 27-letniej kobiety z astmą oskrzelową, która do końca nigdy nie została zdiagnozowana – pacjentkę przyjęto do szpitala z powodu nawracających napadów duszności. Pomimo wdrożonego leczenia antybiotykami i glikokortykosteroidami stan kliniczny chorej, a także obraz radiologiczny uległy pogorszeniu. Na podstawie wykonywanych badań podejrzewano chlamydiowe zapalenie płuc, idiopatyczne rozstrzenie oskrzeli oraz późną postać mukowiscydozy. W badaniach plwociny początkowo nie stwierdzono żadnych patogenów. Ostatecznie badanie bronchoaspiratu metodą BACTEC wykazało obecność prątków gruźlicy. Stan chorej po 6 miesią- cach leczenia przeciwprątkowego według zalecanego przez

  6. WPŁYW SUBSTYTUCJI WŁÓKIEN BAZALTOWYCH PRZEZ WŁÓKNA WĘGLOWE NA WŁAŚCIWOŚCI MECHANICZNE PRĘTÓW B/CFRP (HFRP

    Directory of Open Access Journals (Sweden)

    Kostiantyn PROTCHENKO

    2016-07-01

    Full Text Available W niniejszym artykule przedstawiono analityczne i numeryczne obliczenia mechanicznych właściwości obecnie opracowywanych prętów hybrydowych HFRP (Hybrid Fibre Reinforced Polymer powstałych poprzez zastąpienie (substytucję części włókien bazaltowych BFRP (Basalt Fibre Reinforced Polymer włóknami węglowymi CFRP (Carbon Fibre Reinforced Polymer. W tym aspekcie termin ,,substytucja” rozumiany będzie jako modyfikacja prętów BFRP polegająca na zastąpieniu pewnej części włókien bazaltowych przez włókna węglowe. Celem analizy jest określenie optymalnego modelu prętów hybrydowych HFRP, które stanowiłyby realną alternatywę dla prętów stalowych stosowanych do zbrojenia konstrukcji betonowych. Zamiana włókien bazaltowych, włóknami węglowymi prowadzi do uzyskania lepszych właściwości mechanicznych prętów. Względy ekonomiczne skłaniają do ograniczenia procentowego udziału włókien węglowych w prętach HFRP do rozsądnej wielkości, oraz zastosowaniu włókien węglowych o stosunkowo niedużej wytrzymałości (Low Strength Carbon Fibres jak na włókna CFRP. W pracy przedstawiony został opis struktury pręta hybrydowego, oszacowanie właściwości mechanicznych wzdłuż i w poprzek włókien, a także wpływ układu włókien w przekroju poprzecznym pręta na jego zachowanie mechaniczne. Analizę przeprowadzono dla różnych proporcji udziału włókien węglowych do włókien bazaltowych (1:9; 1:4; 1:3; 1:2; 1:1 w prętach HFRP. Rozpatrzono dwa przypadki rozmieszczenia włókien w przekroju poprzecznym pręta (Bar Architecture. Pierwszy z włóknami węglowymi zlokalizowanymi w rdzeniu, natomiast drugi z włóknami węglowymi usytuowanymi w powierzchniowej warstwie pręta.

  7. Uso de medicações por via subaracnóidea no tratamento da dor crônica

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    Rocha Anita Perpétua Carvalho

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A dor crônica é um desafio para a Medicina atual. Novos métodos e medicamentos têm sido propostos com o intuito de controlar os sintomas álgicos. A via de administração subaracnóidea tem se mostrado como uma alternativa viável e segura, embora necessite continuamente ser objeto de estudo de muitos pesquisadores. O objetivo deste trabalho é fazer uma revisão dos medicamentos disponíveis no arsenal terapêutico já consagrados pelo uso e os que se mostram promissores na atualidade para a prática clínica diária. CONTEÚDO: Nesta revisão são avaliados vários fármacos que apresentam ação analgésica quando utilizada via neuroeixo. Opióides, anestésicos locais, agonistas alfa2-adrenérgicos, antagonistas dos aminoácidos excitatórios e inibitórios, acetilcolina, inibidores da acetilcolinesterase, bloqueadores dos canais de cálcio, adenosina, serotonina, antidepressivos tricíclicos e inibidores da síntese de prostaglandinas são analisados no que concerne aos seus efeitos farmacológicos, incluindo os indesejáveis. CONCLUSÕES: Muitos avanços foram registrados no controle dos sintomas álgicos após a utilização das substâncias citadas por via raquidiana, onde certamente algumas serão aproveitadas e enriquecerão o arsenal terapêutico e outras relegadas temporária ou definitivamente. Entretanto, ainda serão necessários muitos estudos clínicos e experimentais para que estes conhecimentos possam ser incorporados e utilizados com segurança pelos profissionais que lidam com o tratamento da dor crônica.

  8. Intubação orotraqueal: avaliação do conhecimento médico e das práticas clínicas adotadas em unidades de terapia intensiva Orotracheal intubation: physicians knowledge assessment and clinical practices in intensive care units

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    Caroline Setsuko Yamanaka

    2010-06-01

    Full Text Available OBJETIVOS: Avaliar o conhecimento médico sobre as técnicas de intubação e identificar as práticas mais realizadas. MÉTODOS: Estudo prospectivo, envolvendo três diferentes unidades de terapia intensiva de um hospital universitário: da anestesiologia (ANEST, da pneumologia (PNEUMO e do pronto socorro (PS. Todos os médicos que trabalham nessas unidades e que concordaram em participar do estudo, responderam um questionário contendo dados demográficos e questões sobre intubação orotraqueal. RESULTADOS: Foram obtidos 85 questionários (90,42% dos médicos. ANEST teve maior média de idade (p = 0,001, com 43,5% sendo intensivistas. Foi referido uso da associação hipnótico e opióide (97,6% e pré oxigenação (91,8%, mas apenas 44,6% referiram utilização de coxim suboccipital, sem diferença entre as UTIs. Na ANEST, referiu-se maior uso de bloqueador neuromuscular (p OBJECTIVES: To assess the physician’s knowledge on intubation techniques and to identify the common practices. METHODS: This was a prospective study, involving three different intensive care units within a University hospital: Anesthesiology (ANEST, Pulmonology (PULMO and Emergency Department (ED. All physicians working in these units and consenting to participate in the study completed a questionnaire with their demographic data and questions on orotracheal intubation. RESULTS: 85 completed questionnaires were retrieved (90.42% of the physicians. ANEST had the higher mean age (p=0.001, being 43.5% of them intensivists. The use of hypnotic and opioid association was reported by 97.6%, and pre-oxygenation by 91.8%, but only 44.6% reported sub-occipital pad use, with no difference between the ICUs. On ANEST an increased neuromuscular blockade use was reported (p<0.000 as well as increased caution with full stomach (p=0.002. The rapid sequence knowledge was restricted (mean 2.20 ± 0.89, p=0.06 between the different units. The Sellick maneuver was known by 97.6%, but 72

  9. Acceptance Test Data for BWXT Coated Particle Batches 93172B and 93173B—Defective IPyC and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    Coated particle batches J52O-16-93172B and J52O-16-93173B were produced by Babcock and Wilcox Technologies (BWXT) as part of the production campaign for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), but were not used in the final fuel composite. However, these batches may be used as demonstration production-scale coated particle fuel for other experiments. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93172A). Secondary upgrading by sieving was performed on the A-designated batches to remove particles with missing or very-thin buffer layers that were identified during previous analysis of the individual batches for defective IPyC, as reported in the acceptance test data report for the AGR-5/6/7 production batches [Hunn et al. 2017b]. The additionally-upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93172B).

  10. Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain Possível efeito analgésico da vigabatrina na dor neuropática crônica experimental animal

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    NILZA D. ALVES

    1999-12-01

    Full Text Available Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model. For testing pain symptoms, spontaneous (scratching and evoked behaviors to noxious (46o C and non-noxious (40o C thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA on experimental neuropathic pain, as shown by the significant (pO uso de anticonvulsivantes no tratamento de neuralgias despertou um interesse em testar novas drogas anticonvulsivantes, e dentre essas a vigabatrina por possuir mecanismo de ação gabaérgico. Para isso, foram usados 41 ratos Wistar e em 25 deles induziu-se neuropatia ciática constritiva (modelo de Bennett & Xie. Para testar sintomas de dor, foram quantificados comportamentos espontâneos (coçar-se e evocados, por meio de estímulos térmicos nocivos (46oC e não-nocivos (40oC. Além disso, realizou-se estudo comparativo da vigabatrina com outros anticonvulsivantes analgésicos. Os resultados mostraram um possível efeito analgésico, dose-dependente, de vigabatrina (gama-vinil-GABA em dor neuropática experimental. Isso foi evidenciado pela diminuição significativa (p<0,05 do comportamento de coçar-se e pelo aumento significativo (p<0,05 da latência de retirada da pata posterior direita a estímulos térmicos nocivos. Isso foi corroborado por achados semelhantes em experimentos com anticonvulsivantes (carbamazepina, fenitoína e ácido valpróico analgésicos. Esse possível efeito analgésico da vigabatrina (ainda não descrito na literatura não é mediado pelo sistema opióide.

  11. Estudo comparativo da eficácia analgésica pós-operatória de 20, 30 ou 40 mL de ropivacaína no bloqueio de plexo braquial pela via posterior Estudio comparativo de la eficacia analgésica postoperatoria de 20, 30 o 40 mL de ropivacaína en el bloqueo de plexo braquial por la vía posterior A comparative study on the postoperative analgesic efficacy of 20, 30, or 40 mL of ropivacaine in posterior brachial plexus block

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    Marcos Guilherme Cunha Cruvinel

    2007-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As intervenções cirúrgicas por via artroscópica no ombro estão relacionadas com a dor pós-operatória de grande intensidade. Dentre as técnicas de analgesia, o bloqueio do plexo braquial é a que oferece os melhores resultados. O objetivo deste estudo foi determinar qual volume de anestésico local no bloqueio de plexo braquial pela via posterior propicia analgesia pós-operatória para essas operações de maneira mais eficiente. MÉTODO: Noventa pacientes submetidos a bloqueio do plexo braquial pela via posterior foram divididos aleatoriamente em três grupos de 30. Grupo 1 - volume de 20 mL; Grupo 2 - volume de 30 mL; e Grupo 3 - volume de 40 mL. Em todos os grupos, o anestésico usado foi a ropivacaína a 0,375%. O bloqueio foi avaliado por meio da pesquisa de sensibilidade térmica utilizando-se algodão embebido em álcool e a dor pós-operatória foi avaliada seguindo-se uma escala numérica verbal (ENV nas primeiras 24 horas. RESULTADOS: Nos três grupos a analgesia pós-operatória foi similar segundo os parâmetros avaliados; ENV de dor média, tempo até a primeira queixa de dor e consumo de opióides no pós-operatório. No grupo de 20 mL houve um maior consumo de analgésicos não-opióides após a 12ª hora de pós-operatório. Nos grupos de 30 e 40 mL a extensão do bloqueio foi muito maior. CONCLUSÕES: Este estudo mostrou que o bloqueio do plexo braquial pela via posterior é uma técnica que promove analgesia eficaz para intervenções cirúrgicas no ombro. Os três diferentes volumes estudados promoveram analgesia similar. A maior extensão do bloqueio com volumes maiores não se traduziu em melhor analgesia.JUSTIFICATIVA Y OBJETIVOS: Las intervenciones quirúrgicas por vía artroscópica en hombro están relacionadas al dolor postoperatorio de gran intensidad. Entre las técnicas de analgesia, el bloqueo del plexo braquial es el que ofrece los mejores resultados. El objetivo de este estudio

  12. Apnéia na sala de recuperação pós-anestésica: relato de caso Apnea en la sala de recuperación pós-anestésica: relato de caso Apnea in the postanesthetic recovery room: case report

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    Joel Massari Rezende

    2003-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A depressão respiratória é uma complicação que pode ocorrer no pós-operatório quando se utilizam opióides na anestesia. O objetivo deste relato é discutir um caso de apnéia em paciente que chegou consciente à sala de recuperação pós-anestésica (SRPA, após ter sido submetido à tireoidectomia sob anestesia geral com propofol, fentanil e isoflurano. RELATO DO CASO: Paciente do sexo feminino, 50 anos, 60 kg, estado físico ASA I, submetida à tireoidectomia sob anestesia geral induzida com propofol (140 mg, fentanil (350 µg, atracúrio (30 mg e mantida com isoflurano, duas doses subseqüentes em bolus de atracúrio (10 mg cada e ventilação controlada mecânica. No final da cirurgia, após antagonização do bloqueio neuromuscular, a paciente foi extubada, obedeceu aos comandos para respirar e colaborou na passagem à maca, sendo transportada para a SRPA, aonde chegou consciente. Minutos após, apresentou apnéia, cianose e inconsciência. Foi realizada ventilação manual com oxigênio a 100% seguida de injeção de naloxona (0,2 mg por via venosa, havendo retorno da ventilação espontânea e da consciência. CONCLUSÕES: Os cuidados ventilatórios no pós-operatório, durante o transporte, admissão à SRPA e permanência nessa unidade, devem ser contínuos em pacientes que receberam opióides, mesmo demonstrando estar conscientes ao deixarem a sala cirúrgica.JUSTIFICATIVA Y OBJETIVOS: La depresión respiratoria es una complicación que puede ocurrir en el pós-operatorio cuando se utilizan opioides en la anestesia. El objetivo de este relato es discutir un caso de apnea en paciente que llegó consciente a la sala de recuperación pós-anestésica (SRPA, después de haber sido sometido a tireoidectomia sobre anestesia general con propofol, fentanil e isoflurano. RELATO DE CASO: Paciente del sexo femenino, 50 años, 60 kg, estado físico ASA I, sometida a la tireoidectomia sobre anestesia general

  13. Anormalidades de fluxo sangüíneo cerebral em indivíduos dependentes de cocaína Cerebral blood flow abnormalities in cocaine dependent subjects

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    Sergio Nicastri

    2000-06-01

    Full Text Available INTRODUÇÃO: Nos últimos anos, tem havido relatos de anormalidades do fluxo sanguíneo cerebral em indivíduos com o abuso de cocaína, detectadas por meio de tomografia computadorizada por emissão de fóton único (SPECT. Esse padrão anormal de perfusão cerebral tem sido associado a prejuízos cognitivos mas não a alterações observáveis por meio de exames de neuroimagem estrutural. Um problema envolvendo a maioria dos trabalhos publicados sobre esse tema é a inclusão de um grande número de usuários de heroína nas amostras estudadas. Essa outra droga também parece afetar o padrão de perfusão cerebral, particularmente durante estados de abstinência. MÉTODOS: Quatorze pacientes dependentes de cocaína (nenhum com uso de opióides e 14 voluntários normais (grupo controle foram submetidos a exames de SPECT com dímero de etil-cisteína marcado com tecnécio-99m. A análise dos exames de SPECT foi realizada por meio de análise visual qualitativa das imagens obtidas (procedimento padrão na prática clínica, realizada por um radiologista não informado sobre o diagnóstico dos indivíduos avaliados. RESULTADOS: A análise visual revelou um padrão sugestivo de irregularidades do fluxo sangüíneo cerebral em nove pacientes, mas em apenas dois controles (p = 0,018; teste exato de Fisher bicaudal. CONCLUSÕES: Anormalidades de circulação cerebral podem ter relação com prejuízos cognitivos relatados em populações de dependentes de cocaína. Embora déficits de perfusão cerebral associados ao uso de cocaína possam ser irreversíveis, têm surgido relatos na literatura de tratamentos para essas anormalidades de fluxo sangüíneo. Alterações de fluxo sangüíneo cerebral associadas à dependência de cocaína ocorrem mesmo na ausência de abuso ou dependência de opióides.INTRODUCTION: In the last years, there have been reports of abnormalities in brain blood flow of cocaine abusers, detected by single photon computed

  14. Gravity of injury and analgesia in patients who suffered traffic accidents Gravedad de la lesión y analgesia en pacientes que sufrieron accidentes de tránsito Gravidade da lesão e analgesia em pacientes que sofreram acidentes de transporte

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    Ana Maria Calil

    2008-01-01

    fueron de gravedad igual o menor a 3, indicativo de lesiones de gravedad leve, moderada y seria, localizadas principalmente en cuatro regiones corporales; en cuanto a la analgesia, la dipirona apareció como la droga más utilizada y se constató un reducido uso de opioides.OBJETIVOS: Identificar a freqüência e gravidade das lesões em acidentados de transporte e as drogas analgésicas utilizadas. MÉTODOS: Estudo retrospectivo, com amostra de 200 prontuários de pacientes internados no pronto-socorro de um Hospital referência para o atendimento ao trauma. A gravidade das lesões foram caracterizadas por índices de gravidade anatômicos e a terapêutica analgésica com base na Escada Analgésica da Organização Mundial de Saúde. RESULTADOS: Os principais achados apontaram as lesões em membros, cabeça, face e superfície externa como as mais freqüentes, e em 85% dos casos com gravidade menor ou igual que 3; quanto a analgesia verificou-se que 46,6% dos pacientes receberam dipirona e paracetamol , entre os opióides destacou-se a meperidina com 10,4%. CONCLUSÃO: A maioria das lesões foram de gravidade igual ou menor a 3, indicativo de lesões de gravidade leve, moderada e séria, localizadas principalmente em quatro regiões corpóreas; quanto à analgesia, a dipirona apareceu como a droga mais utilizada e constatou-se reduzido uso de opióides.

  15. Remifentanil: o regime de infusão faz diferença na prevenção das respostas circulatórias à intubação traqueal? Remifentanil: ¿el régimen de infusión es la diferencia en la prevención de las respuestas circulatorias a la intubación traqueal? Remifentanil: does the infusion regimen make a difference in the prevention of hemodynamic responses to tracheal intubation?

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    Fernando Squeff Nora

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os opióides em doses elevadas diminuem a resposta circulatória à intubação traqueal. Entretanto, o lento perfil de recuperação dos opióides tradicionais pode limitar a utilização em altas doses. O remifentanil possui tempo de início e de término de ação rápidos e previsíveis, o que o diferencia dos demais. O objetivo primário deste estudo foi verificar a hipótese de que não há necessidade de iniciar a administração de remifentanil antes da indução com o propofol. MÉTODO: Foram avaliados 30 pacientes, divididos em dois grupos, que receberam anestesia geral venosa total. No Grupo 1, a infusão de remifentanil (0,3 µg.kg-1.min-1 foi iniciada dois minutos antes da indução e, no Grupo 2, juntamente com a indução. Foram avaliadas as pressões arteriais sistólica, diastólica e média (PAS, PAD, PAM, freqüência cardíaca (FC, concentrações no local efetor de propofol (CEF-prop e de remifentanil (CEF-remi em três momentos: basal (M0; após a perda do contato verbal (M1; e após a intubação traqueal (M2. RESULTADOS: As pressões arteriais apresentaram reduções significativas em ambos os grupos, em M1 e M2. A CEF-remi foi maior no Grupo 1, em M1 e maior, no Grupo 2, em M2 (p JUSTIFICATIVA Y OBJETIVOS: Los opioides en dosis elevadas disminuyen la respuesta circulatoria a la intubación traqueal. Sin embargo, el lento perfil de recuperación de los opioides tradicionales puede limitar la utilización en altas dosis. El remifentanil posee tiempo de inicio y de término de acción rápidos y previsibles, lo que lo diferencia de los demás. El objetivo primario de este estudio fue verificar la hipótesis de que no hay necesidad de iniciar la administración de remifentanil antes de la inducción con el propofol. MÉTODO: Fueron evaluados 30 pacientes, divididos en dos grupos, que recibieron anestesia general intravenosa total. En el Grupo 1, la infusión de remifentanil (0,3 µg.kg-1.min-1 se

  16. Sedação e analgesia em crianças: uma abordagem prática para as situações mais freqüentes Analgesia and sedation in children: practical approach for the most frequent situations

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    Santiago Mencía Bartolomé

    2007-05-01

    Full Text Available OBJETIVOS: Revisar as indicações, doses e formas de administração dos sedativos, analgésicos e relaxantes musculares mais utilizados na criança, bem como os métodos de monitorização da sedação. FONTES DOS DADOS: Levantamento bibliográfico utilizando a base de dados MEDLINE e revisão da experiência em nossas unidades de cuidados intensivos pediátricos. SÍNTESE DOS DADOS: A administração contínua de drogas analgésicas e sedativas impede o aparecimento das fases de subsedação e requer menor assistência do que na administração intermitente. O midazolan é a droga mais utilizada para sedação contínua da criança gravemente enferma. Os derivados opiáceos e os antiinflamatórios não-hormonais são os analgésicos mais utilizados na criança gravemente enferma. Os opióides associados aos benzodiazepínicos em infusão contínua são os fármacos de eleição em crianças em ventilação mecânica, especialmente a morfina e o fentanil. O uso de protocolos e a monitorização com a utilização de escores clínicos e métodos objetivos como o BIS permitem ajustar mais corretamente a medicação, evitando a supersedação, a subsedação e a síndrome de abstinência. As intervenções não-farmacológicas, como a musicoterapia, o controle de ruídos, a adequada utilização da luz, a massagem e a comunicação com o paciente, são medidas complementares que auxiliam na adaptação da criança ao ambiente hospitalar adverso. CONCLUSÕES: A sedação deve ser adaptada a cada criança em cada momento. O emprego de protocolos que facilitem uma correta seleção de fármacos, uma administração adequada e uma monitorização cuidadosa melhoram a qualidade da sedoanalgesia e reduzem seus efeitos adversos.OBJECTIVES: To review the most frequent recommendations, doses and routes of administration of sedatives, analgesics, and muscle relaxants in children, as well as the methods for monitoring the level of sedation. SOURCES: Review

  17. Lesión de la médula espinal: actualización bibliográfica: fisiopatología y tratamiento inicial Lesão de medula espinal: atualização da literatura: fisiopatologia e tratamento inicial Spinal cord injury: literature update: physiopathology and initial treatment

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    Vicente Ballesteros Plaza

    2012-01-01

    Full Text Available La fisiopatología del trauma raquimedular (TRM es compleja y aún no se conoce completamente. La lesión al cordón espinal está determinada por procesos primarios y secundarios. La lesión primaria se debe a la transmisión de energía mecánica a la médula y las estructuras neurales durante el evento traumático. La lesión secundaria, que compromete estructuras que habían permanecido indemnes después del trauma inicial, desencadena alteraciones en: la perfusión microvascular, la liberación de radicales libres y de neurotransmisores, la peroxidación lipídica, la concentración iónica y la consecuente muerte celular tanto por necrosis como por apoptosis. La investigación en el tratamiento del TRM, basada en el conocimiento actual de estos mecanismos de lesión, ha buscado el desarrollo de intervenciones terapéuticas tempranas que atenúen el efecto de estos mecanismos fisiopatológicos secundarios, tanto en el sitio del accidente, como después del ingreso a un centro de trauma. Dentro de la intervención farmacológica se ha descrito, por su teórico efecto protector en el pronóstico neurológico de los pacientes con TRM, el uso de metil-prednisolona, gangliósidos y medicamentos antagonistas de los opiáceos, del receptor de glutamato y de los canales iónicos. Sin embargo, aún no se ha identificado ninguna intervención que modifique este pronóstico en forma significativa.A fisiopatologia da lesão de medula espinal (LME é complexa e não está completamente esclarecida. A LME é determinada por processos primários e secundários. A lesão inicial é produzida pela transmissão de energia mecânica para a medula espinal e as estruturas neurais. A lesão secundária atua sobre as estruturas que são poupadas pelo trauma inicial, afetando a perfusão microvascular e as concentrações iônicas, desencadeando a liberação de radicais livres e neurotransmissores e ativando a peroxidação lipídica, o que produz a morte celular

  18. Las Farmacodependencias

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    José Francisco Socarrás

    1994-09-01

    Full Text Available

    Ahora, cuando la Corte Constitucional ha despenalizado al farmacodependiente por el consumo de drogas, conviene informar sobre las consecuencias perjudiciales de estas. A quienes deseen un conocimiento detallado al respecto, les recomiendo documentarse en “Enciclopedia de Psiquiatría”, publicada por “El Ateneo” en Buenos Aires.

    El Capítulo respectivo es del doctor Daniel L. Murguia. El denominador corriente de su abuso es sencillamente la dependencia, nombre propuesto por la Organización Mundial de la Salud, definido como el “estado psíquico y a veces físico causado por la interacción entre un organismo vivo y un fármaco”. Su carácter esencial es el impulso psicofísico a consumir el producto en forma continua o periódica, con el fin de experimentar los efectos que acarrea y evitar los malestares de su privación. Todas las drogas del respectivo género, consumidas a dosis altas, tienen efectos psicotóxicos que alteran la conducta y en algunos casos conducen a la muerte.

    Los expertos de la Organización Mundial califican las mencionadas sustancias en seis grupos, a saber:

    1. Morfina y opiáceas, los cuales crean dependencia física y psicológica, con tolerancia precoz, necesidad de aumentar las dosis y síndrome de abstinencia bastante peligroso. Entre los derivados se cuentan los siguientes: Hidromorfina (Dilaudid; oximorfina (Nurmophan; heroína,
    éter diacético de la morfina (Diacetilmorfina; codeína (Metilmorfina; hidrocodeína (Hicadan’ oxicodeína (Perdocan. Los efectos de los opiáceo~ son los siguientes: analgesia, depresión respiratoria y espasmo gastrointestinal. Las dosis tóxicas pueden provocar convulsiones.

    2. Barbitúricos, alcohol y sedantes como el fenobarbital, que provocan así mismo dependencia física.

    3. Anfetaminas, en particular la Bencedrina inhalante, que acarrea dependencia psicológica.

    4. Cocaína, cuya dependencia psíquica es tal que muchos

  19. Fetysz „obiektywności”. „Nasza klasa” Tadeusza Słobodzianka

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    Tomasz Żukowski

    2016-01-01

    completely ignored by the reviewers, however. They were also unable to break through the narration structures of the first type, which are more recognisable. Fetysz „obiektywności”. Nasza klasa Tadeusza Słobodzianka Nasza klasa przyjęta została w Polsce z entuzjazmem. Autora chwalono za odwagę, a jego głos uznano za wyważony i rozsądny w toczącej się od 2000 roku debacie nad zbrodnią w Jedwabnem. Skąd ten entuzjazm, którego brakowało przecież po publikacji Sąsiadów? Jakie zmiany wprowadzone przez Słobodzianka do narracji o Jedwabnem zapewniły mu sukces? Artykuł opisuje recepcję dramatu, która okazuje się wybiórcza. Sięga także do tekstu sztuki, wydobywając dwa porządki prezentowania i objaśniania zdarzeń. W pierwszej warstwie Nasza klasa tworzy obraz stosunków międzyludzkich, w którym znikają społeczne mechanizmy dyskryminacji. Wątek ten podchwytują i rozwijają polscy recenzenci. Wymordowanie Żydów okazuje się następstwem konfliktu równorzędnych grup z podobnymi możliwościami działania i sprawstwa, a więc nieuwikłanych w stosunki dominacji większości nad mniejszością. Stąd wynika symetria krzywd, a w konsekwencji nierozstrzygalność pytania o winę i domniemany tragizm aktorów zdarzeń. Do tego dochodzi psychologiczne wyjaśnianie zachowań i motywacji wzorowane na relacjach rodzinnych. Punkt widzenia uczestników wydarzeń (będący symptomem dyskryminacji zostaje potraktowany jako obiektywizujący opis. Widziane z bliska i psychologizowane perypetie bohaterów zasłaniają tło, jakim jest przemoc grupy dominującej. A tę można wyjaśnić jedynie w kategoriach socjologicznych. Słobodzianek sięga jednak także po opis na poziomie społecznym. Tak konstruuje scenę ślubu Rachelki, rozgrywanie sprawy jej ocalenia po wojnie – niezwykle opisany fenomen społecznego funkcjonowania motywu Sprawiedliwych – dostrzega i opisuje rytuały podporządkowania organizowane dla ocalałych oraz to, jak

  20. Sedação e analgesia em neonatologia Sedación y analgesia en neonatología Sedation and analgesia in neonatology

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    Yerkes Pereira e Silva

    2007-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A importância do estudo da dor em Neonatologia se deve ao fato de que a sensação de dor e estresse significa sofrimento e desconforto para os recém-nascidos e, apesar desse conhecimento, pouco tem sido feito para minimizá-los. Nessa revisão foram discutidas: a prevenção da dor, as medidas não-farmacológicas e farmacológicas para o seu tratamento e a sedação em recém-nascidos. CONTEÚDO: Várias são as medidas não-farmacológicas que podem ser tomadas com intuito de prevenir a dor nas Unidades de Terapia Intensiva Neonatal e também para tornar o ambiente mais humanizado e menos estressante para os pacientes e seus familiares. O tratamento da dor no recém-nascido consiste em medidas não-farmacológicas (sucção não-nutritiva, glicose e farmacológicas (analgésicos não-opióides, opióides e anestésicos locais. A sedação em recém-nascidos é produzida por fármacos que agem diminuindo a atividade, a ansiedade e a agitação do paciente, podendo levar à amnésia de eventos dolorosos ou não-dolorosos. A sedação pode ser feita pela administração de hidrato de cloral, barbitúricos, propofol e benzodiazepínicos. CONCLUSÕES: A prevenção da dor e a indicação de analgesia devem ser individualizadas e sempre consideradas em todos os recém-nascidos portadores de doenças potencialmente dolorosas e/ou submetidos a procedimentos invasivos, cirúrgicos ou não.JUSTIFICATIVA Y OBJETIVOS: La importancia del estudio del dolor en neonatología se debe al hecho de que la sensación de dolor y de estrés significa sufrimiento e incomodidad para los recién nacidos y, a pesar de ese conocimiento poco se ha hecho para reducirlo. Dentro de esa revisión se discutieron: la prevención del dolor, las medidas no farmacológicas ye farmacológicas para su tratamiento y la sedación en recién nacidos. CONTENIDO: Varias son las medidas no-farmacológicas que pueden ser tomadas con el objetivo de prevenir el

  1. Bostezo y epilepsia del lóbulo temporal Yawning and temporal lobe epilepsy

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    S. Muchnik

    2003-04-01

    Full Text Available La epilepsia del lóbulo temporal, es aquella epilepsia parcial donde las estructuras temporales límbicas son las responsables de los principales síntomas ictales. Se caracteriza por la recurrencia de crisis parciales simples y complejas con confusión post-ictal y amnesia del evento. El efecto facilitador del sueño No REM en la propagación de las crisis, como las anormalidades del sueño provocadas por la epilepsia del lóbulo temporal, son evidenciadas claramente en nuestros pacientes. El bostezo es un reflejo fisiológico, principalmente inducido por el despertar y el adormecimiento, puede estar asociado a diferentes enfermedades neurológicas. Su relación con la epilepsia de origen límbico, ha sido escasamente mencionada. Describimos en un paciente, un episodio de bostezos y crisis parcial compleja mientras dormitaba. El EEG mostró actividad irritativa focal, independiente y bilateral en regiones temporales medias. Tratado con carbamazepina 400mg/d, no repitió el episodio. Otro paciente presentó crisis parciales complejas secundariamente generalizadas con episodios de bostezos en el período post-ictal, luego de las siestas. El EEG fue normal y la polisomnografía nocturna mostró actividad irritativa sincrónica y bilateral en regiones temporales medias con generalización secundaria. Tratado con divalproato de sodio 750 mg/d, no se registraron nuevos episodios. La epilepsia del lóbulo temporal, el ciclo sueño-vigilia y el bostezo, parecen compartir no solamente las mismas estructuras anatómicas, sino también los mismos mecanismos neuroquímicos. El hecho de que los opiáceos endógenos sean considerados como parte de un sistema protector que inhibe y previene las crisis, permite postular que el bostezo sería la expresión de los mecanismos inducidos por los opiáceos endógenos que inhiben y previenen las crisis de la epilepsia del lóbulo temporal. Otro punto de vista sería presentar al bostezo simplemente como una forma

  2. Efeitos cardiorrespiratórios da buprenorfina em cães anestesiados pelo desfluorano Cardiorespiratory effects of buprenorphine in dogs anesthetized with desflurane

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    Almir Pereira de Souza

    2005-12-01

    Full Text Available Objetivou-se, com este estudo, avaliar os efeitos da buprenorfina sobre variáveis cardiovasculares e respiratórias em cães durante anestesia com desfluorano. Para tanto, foram utilizados 20 cães adultos, distribuídos em dois grupos (GB e GC. A anestesia foi induzida com propofol (8mg kg-1 IV e em seguida os animais foram intubados com sonda de Magill, a qual foi conectada ao aparelho de anestesia para administração de desfluorano (1,5 CAM. Após 30 minutos, foi aplicado no GB buprenorfina (0,02mg kg-1 e no GC solução de NaCl à 0,9% (0,05ml kg-1. Avaliaram-se: freqüências cardíaca e respiratória (FC e ¦; pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM; débito cardíaco (DC; pressão venosa central (PVC; e as variáveis hemogasométricas pH, PaCO2, PaO2, HCO3, SatO2 e DB. As colheitas dos dados foram feitas aos 30 minutos após o início da administração do desfluorano (MO, 15 minutos após a administração do opióide ou placebo (M15, e a cada 15 minutos após Ml5 (M30, M45, M60 e M75. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (P¦ e o pH tiveram reduções no GB, enquanto a PaCO2 esteve aumentada. Concluiu-se que a inclusão da buprenorfina durante anestesia inalatória pelo desfluorano determina discretas alterações cardiovasculares, bem-como potencializa a hipoventilação promovida pelo desfluorano, com a manifestação de hipercapnia, o que não contra-indica o seu uso em pacientes estáveis.The aim of this study was to evaluate the effects of buprenorphine on cardiovascular and respiratory variables in dogs anesthetized with desflurane. Twenty adult healthy male and female mongrel dogs were randomly distributed in two groups of ten animals each (GB and GC. The anesthetic induction was done using propofol (8mg kg-1, IV, and immediately, the dogs were intubated and submited to desflurane anesthesia administrated at 1.5 MAC. After 30 minutes of induction, animals

  3. Efeitos eletrocardiográficos do butorfanol em cães anestesiados pelo desfluorano Electrocardiographic effects of butorphanol in desflurane anesthetized dogs

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    Paulo Sérgio Patto dos Santos

    2004-08-01

    Full Text Available Objetivou-se com este experimento avaliar as possíveis alterações eletrocardiográficas decorrentes do uso do butorfanol em cães, durante anestesia geral inalatória com desfluorano. Para tal, foram utilizados vinte cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=10 denominados de GS e GB. Os animais foram induzidos à anestesia com propofol (8,4 ± 0,8mg kg-1, IV intubados com sonda orotraqueal de Magill e submetidos à anestesia inalatória pelo desfluorano (10V%. Decorridos 40 minutos da indução, foi administrado aos animais do GS, por via intramuscular, 0,05mL kg-1 de solução fisiológica a 0,9% (salina, enquanto que no GB, foi aplicado butorfanol na dose de 0,4mg kg-1 pela mesma via e em volume equivalente ao empregado no grupo anterior. As observações das variáveis freqüência cardíaca (FC, duração e amplitude da onda P (Ps e PmV, intervalo entre as ondas P e R (PR, duração do complexo QRS (QRSs, amplitude da onda R (RmV, duração do intervalo entre as ondas Q e T (QT e intervalo entre duas ondas R (RR tiveram início imediatamente antes da aplicação do opióide ou salina (M0. Novas mensurações foram realizadas 15 minutos após a administração do butorfanol ou salina (M15 e as demais colheitas foram realizadas à intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75. Os dados numéricos destas variáveis foram submetidos à Análise de Perfil (pThe aim of this work was to evaluate the alterations due to butorphanol administration in desflurane anesthetized dogs over heart rate (HR and electrocardiography (ECG. Twenty adult dogs, males and females, clinically healthy were randomly distributed in two groups of ten animals each (GS and GB. General anesthesia was induced by intravenous administration of propofol (8.4± 0.8mg kg-1 and immediately, the dogs were intubated and submitted to inhalatory anesthesia with desflurane (10V%. After 40 minutes of induction, animals from

  4. Análise clínica e epidemiológica das internações hospitalares de idosos decorrentes de intoxicações e efeitos adversos de medicamentos, Brasil, de 2004 a 2008 Clinical and epidemiological analysis of hospitalizations of elderly due to poisoning and adverse effects of medications, Brazil from 2004 to 2008

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    Tatiana Cruz de Paula

    2012-12-01

    Full Text Available Os idosos são mais suscetíveis aos efeitos adversos dos medicamentos devido a uma diversidade de fatores, tais como o uso excessivo e concomitante de diversos fármacos, erros de administração, alterações fisiológicas no organismo que alteram a farmacodinâmica e a farmacocinética. Com o objetivo de determinar as principais classes terapêuticas envolvidas nas internações hospitalares de idosos decorrentes de intoxicação e efeito adverso de medicamentos, bem como os principais agravos relacionados a esses eventos, foram analisadas 9.793 internações hospitalares de pessoas com 60 anos ou mais, registradas no Brasil pelo Sistema de Internações Hospitalares do SUS (SIH-SUS, no período de 2004 a 2008. Medicamentos não especificados, antibióticos sistêmicos, psicotrópicos, psicoativos, antiepilépticos, sedativos, hipnóticos e antiparkinsonianos, responderam por 57% do total de internações analisadas. Traumatismos e quedas foram os principais agravos relacionados a intoxicação e efeito adverso de medicamentos. As internações por traumatismo apresentaram relação com analgésicos, antitérmicos e antirreumáticos não opiáceos. Já as quedas estavam associadas aos antibióticos sistêmicos, contrariando os estudos que apontam os psicotrópicos como os principais medicamentos envolvidos nesses eventos. Os resultados encontrados refletem a tendência crescente dos problemas associados ao uso de medicamentos por idosos. Verificou-se que o perfil de consumo não é suficiente para explicar as concentrações de casos nas principais classes terapêuticas. Na busca pelas causas, sugere-se a adoção de programas mais efetivos de farmacovigilância, capazes de monitorar as diferentes etapas do processo de uso de medicamentos: prescrição, dispensação, comercialização, administração e adesão ao tratamento.The elderly are more susceptible to adverse drugs effects due to a variety of factors, such as excessive and

  5. Neurobiologia dos transtornos do controle dos impulsos The neurobiology of impulse control disorders

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    Wendol A Williams

    2008-05-01

    Full Text Available OBJETIVO: Revisar os artigos sobre substratos neurobiológicos dos transtornos do controle dos impulsos. O jogo patológico é o foco central desta revisão na medida em que a maioria dos estudos biológicos dos formalmente classificados como transtornos do controle dos impulsos examinou este transtorno. MÉTODO: Foi feita uma busca no banco de dados Medline de artigos publicados de 1966 até o presente para identificar aqueles relevantes para serem revisados neste artigo. DESFECHOS: Estudos pré-clínicos sugerem que a neuromodulação das monoaminas cerebrais está associada à tomada de decisões impulsivas e aos comportamentos de risco. Os estudos clínicos implicam diversos sistemas de neurotransmissores (serotoninérgico, dopaminérgico, adrenérgico e opióide na fisiopatologia do jogo patológico e de outros transtornos do controle dos impulsos. Estudos de neuroimagem preliminares têm indicado o córtex pré-frontal ventromedial e o estriato ventral como atuantes na fisiopatologia do jogo patológico e de outros transtornos do controle dos impulsos. As contribuições genéticas para o jogo patológico parecem substanciais e os estudos iniciais têm relacionado esse transtorno a polimorfismos alélicos específicos, ainda que os achados de varredura genômica ainda tenham que ser publicados. CONCLUSÃO: Mesmo que tenham sido logrados avanços significativos em nossa compreensão sobre os transtornos do controle dos impulsos, mais pesquisas são necessárias para ampliar o conhecimento existente e traduzir esses achados em avanços clínicos.OBJECTIVE: To review the neurobiological substrates of impulse control disorders. Pathological gambling is a main focus of the review in that most biological studies of the formal impulse control disorders have examined this disorder. METHOD: The medical database Medline from 1966 to present was searched to identify relevant articles that were subsequently reviewed to generate this manuscript

  6. Bases neurofisiológicas da dependência do tabaco Neurophysiological basis of tobacco dependence

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    Cleopatra S. Planeta

    2005-10-01

    Full Text Available A maioria dos estudos pré-clínicos e clínicos aponta a nicotina como o principal agente responsável pelo desenvolvimento da dependência ao tabaco. Muitos trabalhos têm demonstrado que as bases neurais da dependência à nicotina são semelhantes àquelas das outras drogas de abuso. A nicotina induz preferência condicionada por lugar e auto-administração e, portanto, atua como reforçador positivo, esse efeito parece ser mediado pelo sistema dopaminérgico mesolímbico. A nicotina também induz à sensibilização comportamental que é provavelmente resultante de alterações da expressão gênica do núcleo acumbens induzidas pela exposição prolongada a essa substância. A suspensão do uso de nicotina resulta em síndrome de abstinência. As evidências indicam que esses sinais e sintomas sejam mediados por receptores colinérgicos nicotínicos centrais e periféricos. Outros neurotransmissores, como por exemplo a serotonina e os peptídeos opióides, também podem estar envolvidos na mediação da dependência e síndrome de abstinência à nicotina. A revisão da literatura mostra a complexidade dos efeitos da nicotina no organismo. A integração entre as abordagens comportamental, neuroquímica e molecular possibilitará a compreensão dos mecanismos neurais da dependência ao tabaco e fornecerá as bases para o desenvolvimento racional de agentes terapêuticos que possam ser utilizados para o tratamento da dependência e síndrome de abstinência ao tabaco.It is generally accepted that nicotine is the major component in tobacco smoke responsible for addiction. Several studies have demonstrated that the neural mechanisms underlying nicotine addiction have much in common with those underlying the mechanisms of addiction to other drugs. Thus, it has been shown that nicotine induces conditioning place preference and self-administration across many species. Repeated treatment with nicotine also induces behavioral sensitization in

  7. Analysis of neutron dose rates on RGTT200K core using MCNP5

    International Nuclear Information System (INIS)

    Suwoto; Zuhair

    2016-01-01

    The conceptual design of RGTT200K (High Temperature Gas-cooled Reactor of 200 MWth Cogeneration) is the non-annular cylindrical reactor core with TRISO kernel coated fuel particles in the form of balls called pebble and cooled by helium gas. The RGTT200K reactor core design adopts high temperature gas cooled reactor (HTGR) technology with inherent passive safety. The RGTT200K spherical fuel called pebble fuel containing thousand of TRISO-coated fuel particles of uranium oxide (UO 2 ) 10 % enriched. TRISO coating comprises four layers, namely: porous carbon buffer layer, inner pyrolytic carbon layer (IPyC, Inner Pyrolytic Carbon), silicon carbide layer (SiC) and a layer of pyrolytic carbon outer portion (OPyC, Outer Pyrolytic Carbon). Modeling and analysis of preliminary calculation of neutron dose rate on normal operating temperature (T kernel =1200K) and accident temperature (T kernel =1800K) of the RGTT200K core were performed using Monte Carlo MCNP5v1.2 code. The continuous energy nuclear data cross-sections was taken from ENDF/B-VII, JENDL-4 and JEFF-3.1 nuclear data files . Double heterogeneity model in TRISO-coated fuel particles kernel and the pebble of RGTT200K core. By utilizing EGS99304 code, the 640 amount of energy group structures (SAND-II neutron group structures) is used in the neutron fluxes and spectrum calculation in RGTT200K reactor. The RGTT200K reactor core is divided into 25 zones (5 zones in radial and 10 zones in axial directions), while the modeling of radiation and biological shielding reactor RGTT200K are used to determine of preliminary neutron dose rate emitted by the neutron source with tally cards are available in the MCNP5v1.2 code. The calculation result analyses of the neutron dose rate distributions are determined using a conversion factor of flux-to-dose taken from International Commission on Radiological Protection, ICRP. The preliminary calculations result show that the neutrons dose rate using ICRP-74 conversion factor for

  8. AGR-1 Compact 4-1-1 Post-Irradiation Examination Results

    Energy Technology Data Exchange (ETDEWEB)

    Demkowicz, Paul Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ploger, Scott A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); van Rooyen, Isabella J. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-02-01

    Destructive post-irradiation examination was performed on AGR-1 fuel Compact 4-1-1, which was irradiated to a final compact-average burnup of 19.4% FIMA (fissions per initial metal atom) and a time-average, volume-average temperature of 1072°C. The analysis of this compact focused on characterizing the extent of fission product release from the particles and examining particles to determine the condition of the kernels and coating layers. The work included deconsolidation of the compact and leach-burn-leach analysis, visual inspection and gamma counting of individual particles, metallurgical preparation of selected particles, and examination of particle cross-sections with optical microscopy, electron microscopy, and elemental analysis. Deconsolidation-leach-burn-leach (DLBL) analysis revealed no particles with failed TRISO or failed SiC layers (as indicated by very low uranium inventory in all of the leach solutions). The total fractions of the predicted compact inventories of fission products Ce-144, Cs-134, Cs-137, and Sr-90 that were present in the compact outside of the SiC layers were <2×10-6, based on DLBL data. The Ag-110m fraction in the compact outside the SiC layers was 3.3×10-2, indicating appreciable release of silver through the intact coatings and subsequent retention in the OPyC layers or matrix. The Eu-154 fraction was 2.4×10-4, which is equivalent to the inventory in one average particle, and indicates a small but measurable level of release from the intact coatings. Gamma counting of 61 individual particles indicated no particles with anomalously low fission product retention. The average ratio of measured inventory to calculated inventory was close to a value of 1.0 for several fission product isotopes (Ce-144, Cs-134, and Cs-137), indicating good retention and reasonably good agreement with the predicted inventories. Measured-to-calculated (M/C) activity ratios for fission products Eu-154, Eu-155, Ru-106, Sb

  9. Różnicowanie infekcyjnego zapalenia krążka międzykręgowego i seronegatywnej spondyloartropatii

    Directory of Open Access Journals (Sweden)

    Maria Maślińska

    2011-06-01

    Full Text Available Objawy infekcyjnego zapalenia krążka międzykręgowego mogąimitować objawy spondyloartropatii seronegatywnych i wymagaćróżnicowania wśród tych jednostek chorobowych (tab. I. Spondyloartropatieseronegatywne to grupa zapalnych chorób przebiegającychz zajęciem stawów kręgosłupa i stawów obwodowych.Wśród zapaleń kości i szpiku infekcyjne zapalenie krążka międzykręgowegostanowi ok. 2–4% wszystkich przypadków. Poniżejprzedstawiono opis przypadku 18-letniego mężczyzny diagnozowanegoz powodu podejrzenia spondyloartropatii. U pacjentawystępowały: ból kręgosłupa o charakterze zapalnym, bóle stawówobwodowych oraz epizody stanów gorączkowych. Po wykluczeniuspondyloartropatii ostatecznie rozpoznano u pacjentainfekcyjne zapalenie krążka międzykręgowego. Dzięki diagnostycemetodą rezonansu magnetycznego możliwe było postawienie diag -nozy (ryc. 1, 2 oraz ocena skuteczności leczenia (ryc. 3, 4. Niew każdym przypadku infekcyjnego zapalenia krążka międzykręgowegomożliwe jest ustalenie czynnika etiologicznego, wówczasw leczeniu należy uwzględnić potencjalne czynniki ryzyka zakażeniaoraz najczęstsze patogeny, będące przyczyną spondylodiscitis,takie jak Staphylococcus aureus (w 50% przypadków i Escherichiacoli (23%. Brak klinicznej poprawy po 2 tygodniach optymalniecelowanej antybiotykoterapii drogą dożylną byłby wskazaniem doleczenia chirurgicznego.Womawianym przypadku rozpoznanie kliniczne potwierdził dobryefekt terapeutyczny prowadzonej antybiotykoterapii, wobec czegonie było wskazań do leczenia operacyjnego. Opisany przypadekwskazuje również na konieczność szybkiej oceny kręgosłupa pierwmetodąrezonansu magnetycznego u pacjentów z bólem zapalnymkręgosłupa i objawami ogólnymi wobec wątpliwości co do ich etiologiii braku wyjaśnienia ich przyczyny klasycznym zdjęciem radiologicznym.Ponieważ bardziej narażeni na infekcyjne zapaleniekrążka międzykręgowego są chorzy z obni

  10. Dynamika zmian temperatury ręki reumatoidalnej po wybranych zabiegach z zakresu termoterapii

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    Małgorzata Gizińska

    2011-08-01

    Full Text Available Wstęp: W procesie usprawniania osób z chorobami reumatycznymi wykorzystuje się wiele zabiegów z zakresu ciepłolecznictwai krioterapii. W dostępnym piśmiennictwie niewiele jest opisówbadań dotyczących efektów termicznych występujących w tkankachw wyniku stosowania takich zabiegów w obrębie ręki reumatoidalnej.Z tego powodu autorzy podjęli próbę określenia przebiegudynamiki zmian temperatury po zastosowaniu powszechniestosowanych u pacjentów z reumatoidalnym zapaleniem stawów(RZS zabiegów z zakresu termoterapii, w aspekcie zmian zachodzącychw mikrokrążeniu podczas 120 minut obserwacji.Materiały i metody: Do dwóch grup przydzielono 27 pacjentówz rozpoznanym RZS (średni wiek badanych 57 ±7,9 roku: I grupaliczyła 14 osób, u których naświetlano jedną rękę promiennikiempodczerwieni IR-A, -B oraz -C, II grupa – 13 osób, u których wykonanozabieg nadmuchu jednej ręki zimnym powietrzem (–30°C.Analizy rozkładu temperatury dokonano na podstawie 120-minutowejobserwacji zmian temperatury powierzchniowej obu rąk, dozapisu której użyto kamery termowizyjnej. U każdej osoby wykonano8 zdjęć termowizyjnych w określonych odstępach czasu:przed zabiegiem, zaraz po zabiegu oraz 5, 15, 30, 45, 60 i 120 minutpo zabiegu.Wyniki: Istotne różnice temperatur mierzonych w kolejnych odstępachczasu zaobserwowano we wszystkich grupach tylko podczas wynopierwszych5 minut po zabiegu (p < 0,05. Maksymalny wzrost temperaturyodnotowany zaraz po zabiegu IR-A, -B, -C wynosił 3,5°C. Ponadmuchu zimnym powietrzem (–30°C maksymalne obniżenietemperatury mierzonej zaraz po zabiegu wynosiło 6,4°C (ryc. 1 i 2.Wnioski: Istotne zmiany temperatury powierzchniowej rąk obserwowanow ciągu pierwszych 5 minut po zabiegu, zarówno ponaświetlaniu IR-A, -B, -C, jak i nadmuchu zimnym powietrzemo temperaturze ok. –30°C. W przypadku zabiegu cieplnego wartośćtemperatury w ciągu tego czasu pozostawała powyżej warto

  11. Yiddish and Judeo-Spanish as Determinants of Identity: As Illustrated in the Jewish Press of the First Half of the Twentieth Century

    Directory of Open Access Journals (Sweden)

    Izabela Olszewska

    2016-12-01

    Full Text Available Yiddish and Judeo-Spanish as Determinants of Identity: As Illustrated in the Jewish Press of the First Half of the Twentieth Century The paper shows an image and functions of Yiddish and Judeo-Spanish languages among Jewish Diaspora groups – the Balkan Sephardim and the Ashkenazim (the Ostjuden group – in the period from the beginning of the twentieth century until the outbreak of World War II. The study is based on the articles from Jewish weeklies, magazines and newspapers from pre-war Bosnia and Hercegovina and from Germany/Poland. It demonstrates a double-sided attitude towards the languages. On the one hand – an image of the languages as determinants of Jewish identity. Touching on this theme, the authors of the paper also try to highlight the images of Yiddish and Judeo-Spanish and as determinants in a narrower sense – of the Sephardi/Ashkenazi identity in that period. On the other hand, the paper shows a tendency to treat the languages as “corrupted” and “dying” languages, and as factors slowing down the assimilation of Jewish groups and also as an obstacle for Zionist ideologies.   Języki jidysz i żydowsko-hiszpański jako wskaźniki tożsamości – na przykładzie żydowskich tekstów prasowych pierwszej połowy XX wieku Artykuł ukazuje obraz i funkcje języków jidysz i żydowsko-hiszpańskiego wśród żydowskich grup diasporowych – bałkańskich Sefardyjczyków oraz Aszkenazyjczyków (Ostjuden – w okresie od początków wieku XX do wybuchu II wojny światowej. Opis oparty jest na artykułach z żydowskich magazynów, tygodników, prasy codziennej z przedwojennej Bośni i Hercegowiny oraz Niemiec/Polski. Ukazany jest ambiwalentny stosunek wobec języków. Z jednej strony – obraz języków jako wskaźników żydowskiej tożsamości, jak również obraz jidysz i żydowsko-hiszpańskiego jako wskaźników tożsamości w węższym ujęciu: tożsamości sefardyjskiej/aszkenazyjskiej w omawianym okresie. Z drugiej

  12. Cortisol sérico e glicemia em cadelas tratadas com tramadol e submetidas à ovário-histerectomia

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    Caldeira Fátima Maria Caetano

    2006-01-01

    Full Text Available O tramadol é um analgésico opióide usado em medicina veterinária, embora existam poucos estudos sobre este fármaco. O objetivo deste trabalho foi avaliar o efeito analgésico promovido pela administração do tramadol, mensurando o cortisol sérico e a glicemia de cadelas. Para isso, foram utilizadas 15 fêmeas, submetidas a ovário-histerectomia sob anestesia geral com isofluorano. Os animais foram divididos em três grupos. Grupo 1 (Tep receberam tramadol pela via epidural (1,0mg kg-1 diluído em água bidestilada ao volume final de 3,0mL e, após 15 minutos, 3,0mL de água bidestilada pela via intravenosa. No grupo 2 (Tiv, foi administrado 3,0mL de água bidestilada pela via epidural e, após 15 minutos, tramadol pela via intravenosa (1,0mg kg-1 diluído em água bidestilada ao volume final de 3,0mL. No grupo 3 (CT, os animais receberam 3,0mL de água bidestilada pela via epidural e, após 15 minutos, 3,0mL de água bidestilada pela via intravenosa. A eficácia de cada regime analgésico foi avaliada durante 12 horas após a administração da injeção epidural. Não houve diferença significativa entre os grupos experimentais para as variáveis estudadas (P>0,05. Foram observadas diferenças significativas dentro de cada tratamento. No grupo Tep houve aumento do cortisol sérico aos 25 minutos do trans-operatório (M3, em relação ao valor obtido imediatamente após a indução anestésica (M2 (P>0,05. Nos tratamentos Tiv e CT, verificou-se elevação das variáveis, duas (M4 e quatro (M5 horas da injeção epidural (P<0,05, quando comparadas ao pré-tratamento (M1. Nesses períodos, as variáveis estudadas no tratamento Tep foram estatisticamente semelhantes ao pré-tratamento (M1. Com base nos resultados, conclui-se que: 1 a metodologia empregada foi sensível para determinar os momentos de maior estresse cirúrgico, dentre os estudados e 2 o tramadol por via epidural produz analgesia mais duradoura quando comparado à administra

  13. Przyczyny oraz czynniki sprzyjające występowaniu zespołu wypalenia zawodowego wśród lekarzy zatrudnionych w publicznych sektorach opieki zdrowotnej

    Directory of Open Access Journals (Sweden)

    Leszek Solecki

    2017-03-01

    Full Text Available Wstęp. Wypalenie zawodowe jest zjawiskiem wystę- pującym coraz częściej wśród pracowników różnych grup zawodowych. Lekarze stanowią grupę bardzo mocno narażoną na ryzyko wystąpienia zespołu wypalenia zawodowego ze względu na charakter wykonywanej pracy. Opis stanu wiedzy. Praca lekarzy i całego personelu nasycona jest czynnikami stresogennymi, które zlokalizowane są w różnych płaszczyznach. Są to cechy osobowościowe, stosunek do pracy oraz struktura i organizacja pracy zawodowej. Wypalenie zawodowe jest procesem długofalowym, w którym kolejne fazy pojawiają się narastająco. Najczęściej wyróżnia się 12 faz. Warunkiem koniecznym dla rozwoju wypalenia zawodowego jest występowanie przewlekłego stresu. Typowymi źródłami stresu występującymi w zawodzie lekarza mogą być: ponoszenie odpowiedzialności za własne działanie, codzienny kontakt z chorobą, wymóg stałej czujności, konieczność kontaktu zarówno z samym chorym jak i jego rodziną, świadomość braku wpływu na losy pacjentów oddziałów opieki paliatywnej, roszczeniowość i niezadowolenie pacjentów, zmianowość, praca w nocy, brak warunków do leczenia (np. złe warunki lokalowe, brak odpowiedniego sprzętu, niedogodności związane z relacjami z personelem szpitala. Podsumowanie. Wypalenie zawodowe można określić jako stan fizycznego, umysłowego i emocjonalnego wyczerpania, który ujawnia się pod postacią chronicznego zmęczenia. Jednocześnie towarzyszy mu negatywna postawa wobec pracy, ludzi i życia, poczucie bezradności oraz beznadziejności położenia. Na wypalenie zawodowe szczególnie narażeni są lekarze, którzy stawiają sobie wysokie cele, są ambitni, dobrze wykonują swoją pracę, pracują pod presją czasu, często na dyżurach trwających wiele godzin.

  14. WSPÓŁCZYNNIK REDUKCJI TEMPERATURY W OBLICZENIACH STRAT CIEPŁA DO PRZESTRZENI NIEOGRZEWANYCH PIWNIC

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    Karolina KURTZ-ORECKA

    Full Text Available Sukcesywne podnoszenie wymagań oszczędności energii, a także zróżnicowanie warunków otoczenia budynku charakterystyczne dla lokalizacji, wymagają szczegółowego podejścia do obliczeń potrzeb cieplnych budynków nowoprojektowanych, jak i istniejących. Zastosowanie w obliczeniach bilansu zapotrzebowania na energię na potrzeby ogrzewania i wentylacji, stałej zryczałtowanej wartości współczynnika redukcji temperatury wydaje się być podejściem niewłaściwym, z uwagi na brak szczegółowych danych krajowych. W artykule, na przykładzie wyników uzyskanych dla trzech obiektów, przedstawiono zmienność współczynnika redukcji temperatury stropów nad nieogrzewanymi piwnicami, w zależności od izolacyjności termicznej przegród zamykających przestrzeni ogrzewaną i nieogrzewaną oraz warunków środowiska zewnętrznego. Wykazano, że zastosowanie do obliczeń potrzeb cieplnych budynku stałej wartości współczynnika redukcji temperatury wiąże się z przeszacowaniem start ciepła z powierzchni stropu nad nieogrzewanymi piwnicami, co prowadzi do istotnego niedostosowania modelu obliczeniowego budynku w odniesieniu do jego rzeczywistego stanu. Przy projektowaniu budynków przeszacowanie zużycia energii często wiąże się z koniecznością wprowadzania kosztownych rozwiązań pozwalających na dotrzymanie wartości granicznych wskaźnika zapotrzebowania na nieodnawialną energię pierwotną, stąd poprawność przyjętego modelu obliczeniowego nabiera istotnej wagi. W przypadku budynków istniejących poddawanych procesowi termomodernizacji, szczegółowo wyznaczony współczynnik redukcji temperatury, a za tym straty ciepła, pozwalają na wskazanie oszczędności energii związanej z ociepleniem ścian nieogrzewanych piwnic. Dokładny opis modelu budynku jest również istotny przy rozliczaniu wsparcia finansowego udzielonego na poprawę efektywności energetycznej budynku i raportowaniu z osiągniętego efektu

  15. Analysis of prescription and dispensation of psychotropic medications in two cities in the State of São Paulo, Brazil Análise da prescrição e dispensação de medicamentos psicotrópicos em dois municípios do Estado de São Paulo

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    Ana Regina Noto

    2002-06-01

    digitados e tabulados. RESULTADOS: Foram processadas 108.215 prescrições, sendo 76.954 de benzodiazepínicos, 26.930 de anorexígenos, 3.540 de opiáceos e 788 de outros. Os benzodiazepínicos mais freqüentes foram: diazepam (31.644, bromazepam (16.911 e clonazepam (7.929 e, entre os anorexígenos, dietilpropiona (14.800 e femproporex (10.942. As mulheres, em geral, receberam mais prescrições em comparação com os homens, especialmente para os anorexígenos, com uma relação dez vezes maior nas prescrições de dietilpropiona e femproporex. As poucas farmácias de manipulação (n=6 chegaram a movimentar mais prescrições do que as drogarias (n=49. Também foi detectada uma série de erros e incoerências nas prescrições analisadas. CONCLUSÕES: Os resultados confirmam a ocorrência de uso irracional e uma série de práticas inadequadas que envolvem a prescrição desses medicamentos no Brasil e, portanto, indicam a necessidade de uma ampla revisão no atual sistema de controle dessas substâncias no país.

  16. Używki w ciąży – alcohol = Stimulants in pregnancy – alcohol

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    AGNIESZKA KONSTANCJA PAWŁOWSKA-MUC

    2015-08-01

    Używki w ciąży - alkohol Streszczenie Wprowadzenie. Spożywanie alkoholu kobiety w wieku rozrodczym jest problemem wielu krajów świata. Stwarza ono duże zagrożenie dla ich zdrowia prokreacyjnego, prawidłowego przebiegu ciąży, zdrowia noworodka i dziecka w późniejszym okresie jego życia. Cel pracy. Celem pracy było ukazanie skali problemu oraz skutków spożywania alkoholu przez kobiety w okresie ciąży. Skrócony opis stanu wiedzy. Z przeglądu piśmiennictwa wynika, iż skala problemu jest trudna do oszacowania. Negatywnych skutków jest zdecydowanie więcej niż pozytywnych. Dotychczas nie określono jeszcze bezpiecznej dawki alkoholu dla ciężarnych, a kobiet spożywających napoje alkoholowe w tym czasie jest wciąż za duża. Świadomość konsekwencji takich zachowań nie zawsze idzie w parze z całkowitą rezygnacją z picia alkoholu podczas ciąży. Podsumowanie. Istnieje potrzeba większego niż dotychczas angażowania się pracowników medycznych (lekarzy położników i położnych w działalność nie tylko informacyjną, lecz także edukacyjną i wspierającą.   Słowa kluczowe: alkohol, ciąża, płód, zdrowie.                                             Stimulants in pregnancy - alcohol Abstract Introduction. Alcohol consumption by women in the reproductive period is a current problem in many countries around the world. It poses a great threat to their reproductive health, the correct parturition, the health of the newborn and the child in the later part of its life. Aim. It was the aim of this work to present the scale of the problem as well as the results of women’s alcohol consumption during pregnancy. Brief description of the state of the art. The review of the bibliography indicates that the scale of the problem is hard to assess. Negative effects are much more prevalent than the positive ones. A safe unit dose for pregnant women has not yet been established and the number of women

  17. Negligência das classificações diagnósticas atuais com os fenômenos dissociativos do transtorno de estresse pós-traumático Negligence of current diagnostic classifications in dissociative phenomena of posttraumatic stress disorder

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    Alessandra Azevedo Lima

    2007-01-01

    Full Text Available CONTEXTO: Apesar da importância crescente da dissociação no transtorno de estresse pós-traumático (TEPT, os sintomas dissociativos não são contemplados pelos critérios diagnósticos das classificações oficiais (CID-10 e DSM-IV. A hipótese de um subtipo dissociativo para o TEPT tem sido corroborada por pesquisas em psicofisiologia, neuroimagem funcional, psicoendocrinologia e sistemas opióides. Pretende-se demonstrar a insuficiência dos critérios vigentes na detecção dos sintomas dissociativos no TEPT mediante relato de um caso com sintomas dissociativos persistentes desde o trauma. RELATO DE CASO: O paciente preenche critérios para TEPT e transtorno depressivo maior pelo DSM-IV. Embora também preencha critérios para transtorno de despersonalização, esse diagnóstico é impossibilitado na presença de TEPT. O paciente apresentou sintomas conversivos peritraumáticos, avaliados pela Escala de Imobilidade Tônica, e sintomas dissociativos proeminentes, peritraumáticos e atuais, já que obteve escores significativos no Questionário de Experiências Dissociativas Peritraumáticas e na Escala de Experiências Dissociativas. Após 3 anos de tratamento, não houve melhora do quadro. CONCLUSÃO: O reconhecimento da importância dos fenômenos dissociativos/conversivos no TEPT poderá contribuir para o aprimoramento do diagnóstico, investigações sobre sua fisiopatologia e o desenvolvimento de tratamentos mais eficazes.BACKGROUND: In spite of the growing importance of dissociation in post traumatic stress disorder (PTSD, dissociative symptoms are not included in the diagnostic criteria of official classifications (CID-10, DSM-IV. Research in psychophysiology, functional neuroimaging, psycho-endocrinology and opioid systems provides support for a dissociative subtype of PTSD. CASE REPORT: A case study on a PTSD patient with persistent dissociative symptoms since the trauma will show that current criteria are insufficient for

  18. Consumo de Álcool e Outras Drogas em uma Faculdade de Medicina do Sul de Minas Gerais / Consumption of Alcohol and Other Drugs in a Medical School in Southern Minas Gerais

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    Jorge Gelvane Tostes

    2016-06-01

    Full Text Available Objetivo: Traçar o perfil e estabelecer a prevalência do consumo álcool e/ou outras drogas entre os estudantes de uma faculdade de medicina do Sul de Minas Gerais. Materiais e Métodos: Os dados foram coletados com 419 alunos matriculados na faculdade no ano de 2013, a partir de questionário anônimo, o qual apresentou variáveis de idade, sexo, série do curso, uso de bebida alcoólica e drogas, frequência no ultimo mês (Julho/2013. Resultados: Constatou-se que 99% dos estudantes entrevistados já fizeram uso de bebida alcoólica ao menos uma vez na vida, sendo que 73% relataram que o ingresso na faculdade aumentou o consumo. Observou-se que o consumo é maior entre o sexo masculino. Quanto ao uso de outras drogas, 43,6% dos entrevistados relataram que fizeram uso ao menos uma vez na vida. No último mês (Julho/2013, 87,6% consumiram álcool, 23,4% tabaco, 13,4% maconha, 6,9% estimulantes, 6,2% tranquilizantes, 5,5% inalantes, 4,8% alucinógenos, 1,7% cocaína /crack, 0,2% opiácios. Conclusão: Os dados mostram que estudantes de medicina desta faculdade tendem a consumir drogas até duas vezes mais do que população em geral, A droga mais usada continua sendo o álcool, mas há consumo expressivo de outras substâncias como a maconha e cocaína. Objective: To describe a profile and establish the prevalence of alcohol consumption and / or other drugs among students of a medical school in southern Minas Gerais. Materials and Methods: Data were collected with 419 students enrolled in college in 2013 , from anonymous questionnaire , which presented variables of age, sex, year in the course, use of alcohol and drugs, frequency in the last month (July / 2013. Results: 99% of surveyed students were found to have already made use of alcohol at least once in their lifetime, and 73% reported entrance in college increased consumption. Higher consumption was observed among males. Regarding use of other drugs, 43.6% of the respondents have used

  19. Betel leaf toothpastes inhibit dental plaque formation on fixed orthodontic patients

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    Rizka Amelia Mayasari

    2011-12-01

    Full Text Available Background: Brackets, archwires, ligatures, and other fixed orthodontic appliance components complicate the use of conventional oral-hygiene measures. This often results in significant plaque accumulation around the bracket bases. The addition of betel leaf extract in toothpaste is expected to inhibit the growth of dental plaque. Purpose: The purpose of this study was to evaluate the effect of betel leaf toothpaste in inhibiting plaque formation on the fixed orthodontic patients. Methods: This study was done on dental student of Airlangga University aged 18–24 years, have been wearing fixed orthodontic appliances for 1–2 years, have no systemic diseases. The samples were divided into two groups, consisting of 20 samples. First group of samples brushed their teeth with betel group of samples brushed their teeth with betel brushed their teeth with betel leaf toothpaste and the second using placebo. The subjects were instructed to brush their teeth using Scrub method until reaching zero (0 scor of orthodontic plaque index (OPI. Plaque scores were taken again 4 hours after brushing. The statistical analysis was done by using paired t test. Results: The average of accumulated plaque on group that use betel leaf toothpaste was 25.54 and placebo was 41.09. The result showed that there was significant difference in plaque accumulation between the group with betel leaf toothpaste and placebo 4 hours after brushing (p = 0.001. Conclusion: In conclusion, betel leaf toothpaste is effective in inhibiting the dental plaque formation on the fixed orthodontic patients. Latar belakang: Bracket, kawat busur, kawat ligatur dan komponen peranti ortodonti cekat yang lain mempersulit pembersihan gigi secara konvensional. Hal ini sering menyebabkan terjadinya akumulasi plak di sekitar dasar braket. Penambahan ekstrak daun sirih yang mempunyai efek bakterisid pada pasta gigi diharapkan dapat menghambat pertumbuhan plak. Tujuan: Tujuan penelitian ini adalah untuk

  20. Niewirusowy transfer genów do komórek skóry – wybrane metody = Non-viral gene transfer into skin cells – selected methods

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    Ewelina Wędrowska

    2016-01-01

    3Department of Pathobiochemistry and Clinical Chemistry, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland       Streszczenie   Wprowadzenie: Skóra jako największy i najłatwiej dostępny narząd stanowi atrakcyjny cel dla terapii genowej, która od wielu lat budzi ogromne nadzieje środowiska naukowego. Jednakże, próby terapii przeprowadzone z wykorzystaniem wektorów wirusowych wykazały szereg wad i ograniczeń m.in. obserwowano indukcję odpowiedzi immunologicznej, losową integrację transgenu z genomem gospodarza i/lub niską wydajność jego ekspresji. Dlatego, wciąż poszukuje się alternatywnych, skuteczniejszych i jednocześnie bezpieczniejszych metod transferu genów. Atrakcyjnej alternatywy upatruje się w metodach niewirusowych. Cel pracy: Przedstawienie wybranych metod niewirusowego transferu genów wykorzystywanych w terapii genowej chorób skóry. Skrócony opis stanu wiedzy: Terapia genowa chorób skóry obejmuje wykorzystanie wektorów plazmidowych jako nośnika genów terapeutycznych, a także metod ich dostarczania do komórek takich jak: elektroporacja, mikroiniekcja, sonikacja, wykorzystanie nośników lipidowych i polimerów kationowych. Podsumowanie: Niewirusowe metody transferu genów oferują pewne zalety włączając niską toksyczność, brak infekcyjności oraz łatwość i niskie koszty produkcji w porównaniu z technikami wirusowymi. Niewirusowe metody wydają się być obiecującym narzędziem terapii genowej chorób skóry w szczególności nowotworów tego narządu.   Słowa kluczowe: plazmid, transfer genów, skóra, wirus, terapia genowa.     Summary Introduction: Skin, the largest and most accessible organ of the human body is considered as an ideal gene therapy target. However, various types of viral vectors used in classical gene therapy have a number of disadvantages, such as possibility of immune response induction, random integration of inserts into the host genome or low expression efficiency

  1. Acesso rápido à via aérea Rapid airway access

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    Sérgio L. Amantéa

    2003-11-01

    Full Text Available OBJETIVO: O artigo visa rever os passos da obtenção de uma via aérea segura no atendimento da criança criticamente enferma. FONTES DOS DADOS: Revisão de artigos a partir da busca na base de dados Medline até abril de 2003, utilizando os unitermos intubação, crianças e sedação. SÍNTESE DOS DADOS: O comprometimento da via aérea é incomum, porém quando ocorre, depende de profissionais treinados para a rápida obtenção da via aérea, de maneira segura, precoce e sem causar prejuízos para tais pacientes. O método preconizado para tal abordagem é a seqüência rápida de intubação que além de preparação, utiliza sedação e bloqueador neuromuscular. Observamos que não é possível a aplicação de um protocolo único de intubação, pois depende da indicação e condições do paciente. Definimos doses das medicações mais utilizadas em nosso meio, pois acreditamos que pouco se conhece do real efeito de drogas sedativas e analgésicas. Na maioria das situações, a associação de um analgésico opióide (fentanil na dose de 5 a 10 µg/kg e um sedativo (midazolam 0,5 mg/kg e um bloqueador neuromuscular são suficientes para a intubação traqueal. CONCLUSÕES: Treinamento, conhecimento, habilidade na obtenção da via aérea são fundamentais para o intensivista pediátrico e são vitais para o adequado atendimento de crianças gravemente enfermas. Apresentamos um texto objetivo e dinâmico, visando a oferecer subsídios para a geração de protocolos a serem implementados de acordo com facilidades e dificuldades de cada serviço.OBJECTIVE: To review the steps involved in safe airway management in critically ill children. SOURCES OF DATA: Review of articles selected through Medline until April 2003 using the following key words: intubation, children, sedation. SUMMARY OF THE FINDINGS: Airway compromise is rare, but whenever it occurs, the situation depends on professionals trained to carry out safe, early, and rapid airway

  2. Frakcja lipidowa i białkowa nasion konopi siewnych (C. sativa L. oraz jej korzystny wpływ na zdrowie człowieka = Lipid and protein fraction of hemp seed (C. sativa L. and its beneficial influence on human health

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    Grzegorz Dąbrowski

    2016-09-01

      Abstrakt Wprowadzenie i cel pracy: Konopie siewne wykorzystywane są od tysięcy lat do produkcji włókien oraz oleju z nasion. W ostatnim czasie nasiona tej rośliny wykorzystuje się także do produkcji izolatów i hydrolizatów białek. Celem niniejszej pracy jest opisanie składu frakcji tłuszczowej i białkowej nasion konopi siewnych oraz potencjału zdrowotnego oleju oraz izolatów i hydrolizatów białkowych pochodzących z tego surowca. Skrócony opis stanu wiedzy: Nasiona konopi są bogatym źródłem oleju oraz białka. Skład oleju jest korzystny z żywieniowego punktu widzenia z uwagi na duży udział niezbędnych nienasyconych kwasów tłuszczowych (NNKT oraz korzystne proporcje kwasów n-6/n-3. Olej konopny zawiera także duże ilości związków bioaktywnych, takich jak fitosterole, karotenoidy, polifenole i tokoferole. Białko konopi cechuje się dobrym składem aminokwasów oraz jest źródłem bioaktywnych peptydów o działaniu antyoksydacyjnym. Podsumowanie: Ze względu na zawartość oleju o korzystnym składzie kwasów tłuszczowych i wartościowego białka, nasiona konopi powinny być coraz częściej wprowadzane do codziennej diety. Słowa kluczowe: konopie siewne, NNKT, bioaktywne peptydy, tokoferole, fitosterole, polifenole, karotenoidy   Abstract Introduction and purpose: Hemp are used for thousands of years to obtain the fiber and seed oil. Recently, the hemp seeds are also used for the production of protein hydrolysates and isolates. The aim of this study is to describe the composition of the fat and protein fractions. In addition health benefits of the consumption of the oil  and protein hydrolysates and isolates will be described. Brief description of the state of the knoweledge: Hemp seeds are a rich source of oil and protein. The oil composition is beneficial from a nutritional point of view due to the high content of essential fatty acids (EFAs in the optimal ratio of n-6 / n-3. Hemp oil also contains large amounts of a

  3. Medicamentos de venta libre en el Brasil

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    Isabela Heineck

    1998-06-01

    Full Text Available En el presente estudio se analizaron los 100 productos del mercado farmacéutico popular (de venta libre más vendidos en el Brasil, en el período comprendido entre junio de 1992 y junio de 1993. Se excluyeron 23 productos alimentarios clasificados como medicamentos. La muestra, formada por 77 medicamentos, representaba aproximadamente 67% del consumo en valores y 76,8% del consumo en unidades de las especialidades vendidas en el mercado popular. Para la clasificación de los medicamentos, se utilizó el sistema anatómico-terapéutico-químico (ATC. Las especialidades también se clasificaron con la metodología del valor intrínseco, que considera la eficacia y los riesgos de las mismas. La mayoría de las especialidades (91% mostraron "poco valor intrínseco" (dudoso/nulo, relativo, inaceptable, y 70% correspondieron a combinaciones en dosis fijas. Solo 10 especialidades pertenecían a la Relación Nacional de Medicamentos, producida por el Ministerio de Salud, y cuatro a la lista de medicamentos esenciales de la OMS. Los grupos terapéuticos a los que pertenecían las especialidades fueron, en orden de mayor a menor frecuencia, el aparato digestivo, la piel, el aparato genitourinario, el aparato musculosquelético, el sistema nervioso central, los antiparasitarios, el aparato respiratorio y los órganos de los sentidos. El subgrupo terapéutico de mayor venta fue el de preparaciones para la garganta, mientras que el que representó el mayor valor en ventas fue el de los analgésicos no opiáceos y antipiréticos. Los resultados confirman la hipótesis planteada de que los medicamentos de venta libre en el Brasil presentan mala calidad terapéutica y de que el consumo de muchas de estas especialidades farmacéuticas representa gastos innecesarios para la población. Se puede afirmar también que algunos de esos medicamentos no deberían estar disponibles para una población que no está al corriente de las complicaciones asociadas con su

  4. Programas de mantenimiento de metadona con servicios auxiliares: un estudio de coste-efectividad Methadone maintenance programs with supplementary services: a cost-effectiveness study

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    E. Puigdollers

    2003-04-01

    Full Text Available Objetivo: Actualmente, los programas de mantenimiento con metadona (PMM son la mejor alternativa de tratamiento para los adictos a opiáceos. Se pretende valorar el coste-efectividad de tres PMM que ofrecían diferentes servicios auxiliares utilizando como medida de efectividad el incremento de la calidad de vida. Métodos: Estudio de seguimiento a 12 meses de 586 pacientes que iniciaron tratamiento con metadona en los centros de atención y seguimiento municipales de Barcelona. Para medir la evolución de la calidad de vida se utilizó el Perfil de Salud de Nottingham (PSN. Se calcularon los costes unitarios estándar y el coste total por paciente a partir de los registros de actividad. Los datos sociodemográficos, de salud y toxicológicos se obtuvieron a través de una entrevista semiestructurada. El análisis coste-efectividad se realizó mediante dos modelos multivariados con idénticas variables de ajuste. Resultados: Cuanto mayor es la intensidad de programa, más elevado es el coste. Los modelos ajustados detectaron un aumento significativo de la calidad de vida (mejora de un 8% en el PSN y de los costes (17% entre el programa de intensidad baja y el de intensidad media. Conclusiones: El programa de media intensidad demostró la mejor relación coste-efectividad pero, dadas las limitaciones del estudio, es difícil ser taxativo en la generalización de sus resultados.Objective: Methadone maintenance programs (MMP currently offer the best treatment for opioid-addicted patients. The aim of this study was to examine the cost-effectiveness of three MMPs that offered varying levels of supplementary services. Health-related quality of life was used as a measure of effectiveness. Methods: A 12-month follow-up study of 586 patients beginning methadone treatment in Drug Care Centers in Barcelona was performed. The Nottingham Health Profile was used to measure quality of life. Standard unit costs and total cost per patient were calculated from

  5. Avaliação da analgesia pós-operatória em pacientes submetidos à cirurgia orificial com anestesia local associada ou não à morfina Evaluation of the postoperative analgesia in patients submitted to anorectal surgery with local anesthesia associated or not the morphine

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    Juvenal da Rocha Torres Neto

    2007-03-01

    Full Text Available Ainda não esta comprovada a eficácia dos derivados morfínicos ao nível de receptores opióides periféricos. Estudos procuram demonstrar o poder da droga em interferir na intensidade da dor quando infiltrada em nervos periféricos. Avaliamos, então, a infiltração local de morfina associada à anestesia local em cirurgias orificiais proctológicas. Nesse estudo foram analisados 61 pacientes, independentemente do gênero, sendo divididos aleatoriamente em dois grupos: a um grupo foi associada morfina ao anestésico local enquanto ao outro houve a administração do anestésico local sem a droga morfínica. Os pacientes de ambos os grupos foram submetidos à sedação e analgesia pós-operatória padronizadas. Foram avaliados: a intensidade da dor, a analgesia pós-operatória e a morbidade. A intensidade da dor, no momento de seu surgimento, foi semelhante nos dois grupos; o tempo de analgesia pós-operatória foi maior no grupo em que a morfina foi administrada, entretanto, não se mostrou estatisticamente significativo; as complicações pós-operatórias foram irrelevantes nos dois grupos. Dessa forma, a infiltração local de morfina na região anorretal tem benefícios em relação à analgesia pós-operatória que não mostraram significância estatística e não aumenta a incidência dos efeitos colaterais tão temidos relacionados às drogas morfínicas como retenção urinária e prurido.It has not been proved the efficacy of morphine derived at periphery opium receivers. Studies are trying to demonstrate the power of the drug to interfere in the intensity of surgical pain while infiltrating in the periphery nerves. This study evaluated the infiltration of morphine associated with local anesthesia in anorectal surgery. Sixty one patients were analyzed, male and female, divided in two groups: in one group was associated morphine in the local anesthesia while in the other group only the local anesthetic was used. The patients of both

  6. Neuroprotección en la encefalopatia hipóxico isquémica perinatal: Tratamientos con eficacia clínica demostrada y perspectivas futuras Neuroprotection in perinatal hypoxic-ischemic encephalopathy: Effective treatment and future perspectives

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    Agustín Legido

    2007-01-01

    Full Text Available El objetivo de este trabajo es revisar el resultado de estudios clínicos recientes que han demostrado el efecto neuroprotector de algunas terapias en la encefalopatía hipóxico-isquémica (EHI perinatal y presentar las perspectivas futuras de otras investigaciones clínicas y experimentales. Terapias con eficacia clínica demostrada. Alopurinol: Bloquea la producción de radicales libres tras hipoxia-isquemia. En un estudio reciente, los niños con corazón izquierdo hipoplásico tratados con alopurinol, pero no aquéllos con otras cardiopatías, tuvieron un número significativamente menor de complicaciones que los controles, incluyendo muerte, convulsiones, coma o problemas cardíacos. Opiáceos: En otro estudio reciente, un grupo de recién nacidos con EHI tratados con morfina o fentanil tuvieron un grado menor de lesión cerebral en la RMN y un mejor pronóstico neurológico. Hipotermia: Tanto la hipotermia localizada (cerebral como la sistémica (todo el cuerpo tienen un efecto neuroprotector en recién nacidos seleccionados tras sufrir EHI. Perspectivas Futuras. Fármacos antiepilépticos. Estos tienen mecanismos de acción múltiple que pueden bloquear la cascada bioquímica de lesión neuronal en EHI. Otras modalidades terapéuticas. Entre ellas hay que destacar el estudio de la terapia neuroprotectora combinada, los factores de crecimiento, la terapia genética, el transplante de células madre y la vacunación neuroprotectora. En conclusión, un mejor conocimiento de los mecanismos moleculares de la patogenia de la EHI y mejores estudios clínicos con terapias neuroprotectoras abrirá nuevas posibilidades terapéuticas aplicables en la práctica clínica. Todo ello mejorará sin lugar a duda el pronóstico de los recién nacidos con EHI.The aim of this paper is to review the results of recent clinical studies of some therapies that have demonstrated a neuroprotective effect in perinatal hypoxic-ischemic encephalopathy (HIE and to

  7. Cetamina: aspectos gerais e relação com a esquizofrenia Ketamine: general aspects and relationship with schizophrenia

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    Silvânia M. M. Vasconcelos

    2005-01-01

    Full Text Available A cetamina é uma droga anestésica desenvolvida em 1965 pelos laboratórios norte-americanos Parke & Davis, tendo como objetivo principal sua utilização em anestesias humanas e veterinárias. Entretanto, seu uso tornou-se constante entre os jovens, sendo consumida em festas como um potente alucinógeno. Já quanto a pesquisas laboratoriais, essa droga tem sido utilizada como modelo para induzir esquizofrenia em animais. Com o objetivo de realizar-se um estudo de revisão da cetamina como anestésico e potencial modelo de esquizofrenia, foi feita uma pesquisa bibliográfica na internet, utilizando programas de pesquisa científica (Pubmed, Medline e Lilacs, além de pesquisa em trabalhos relacionados ao assunto. A administração da cetamina no homem promove o bloqueio dos receptores glutamatérgicos ionotrópicos do tipo N-metil-D-aspartato (NMDA e antagoniza os receptores de acetilcolina nicotínicos e muscarínicos, bem como os receptores monoaminérgicos e opióides. O bloqueio dos receptores glutamatérgicos promoverá um quadro sintomático semelhante ao de um paciente esquizofrênico. Além disso, a administração da cetamina durante a sinaptogênese pode lesar neurônios corticais, límbicos, talâmicos e estriatais, promovendo uma disfunção na neurotransmissão glutamatérgica e propiciando a manifestação de sintomas psicóticos na vida adulta. Entre esses sintomas, podemos citar o surgimento da esquizofrenia. Somando-se a isso, a droga proporciona uma série de efeitos sistêmicos, desde uma simples anestesia, passando pela sedação, depressão respiratória e até a morte.Ketamine is an anesthetic agent developed in 1965 by Park & Davis laboratories to be used as a general anesthetic in humans and animals. However, its use became popular among young people and it's frequently available at parties to produce hallucination. In laboratorial researches, this drug has been used as a model of schizophrenia in animals. This work

  8. „В името на Кирил и Методий“. Кирило-методиевската идея и социалистическата пропаганда

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    Десислава [Desislava] Найденова [Naĭdenova

    2017-10-01

    Full Text Available “In the name of Cyril and Methodius”: The Cyrillo-Methodian idea and the socialist propaganda The paper aims to describe and analyze the dynamics of transformation undergone by the symbolism of the Cyrillo-Methodian oeuvre in the socialist propaganda in Bulgaria. The work and lives of the two saints represent the different national paradigms and state priorities before and after 1944. In the years from 1878 to 1944, St. Cyril and Methodius became a symbol of Bulgarian national identity. They were used in political propaganda to justify the Bulgarian territorial claims in the Balkans in an attempt to achieve the national ideal. On the contrary, after the socialist propaganda during the years of World War II, the Cyrillo-Methodian work became a symbol of Slavic unity and solidarity with the Soviet Union. The idea of Cyril and Methodius as a symbol of internationalism and fraternal unity of the Slavic peoples was developed by socialist propaganda in the years after 1944 and has in fact dominated the scientific interpretations of their work from that time on. The paper is based on unpublished communist addresses from the feast of St. Cyril and Methodius in 1942 and 1943 and other documents from the Central State Archives in Sofia and the Scientific Archives of the Bulgarian Academy of Sciences.   „W imię Cyryla i Metodego”. Idea cyrylometodejska i propaganda socjalistyczna Celem artykułu są opis i analiza dynamiki transformacji symboliki misji cyrylometodejskiego w propagandzie socjalistycznej w Bułgarii. Dzieło i życie śś. Cyryla i Metodego wpisują się w różne paradygmaty narodowe i priorytety państwowe przed i po roku 1944. W okresie od 1878 do 1944 roku stali się oni symbolem bułgarskiej tożsamości narodowej. Ich figury są używane w propagandzie politycznej, aby uzasadnić bułgarskie pretensje terytorialne na Bałkanach w dążeniu do osiągniecia narodowego ideału. Natomiast w wyniku propagandy socjalistycznej w

  9. Consumo de substâncias psicoativas por adolescentes escolares de Ribeirão Preto, SP (Brasil. I - Prevalência do consumo por sexo, idade e tipo de substância

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    Gilson M. Muza

    1997-02-01

    Full Text Available INTRODUÇÃO: A preocupação suscitada quanto ao consumo de substâncias psicoativas pelos adolescentes tem mobilizado grandes esforços em todo o mundo na produção de conhecimento sobre este fenômeno. Decidiu-se estudar as taxas de prevalência de consumo de substâncias psicoativas de uso lícito e ilícito, sua distribuição por idade, sexo e a idade da primeira experiência com essas substâncias, entre adolescentes escolares do Município de Ribeirão Preto, SP, Brasil. MATERIAL DE MÉTODO: Um questionário devidamente adaptado e submetido a um teste de confiabilidade foi auto-aplicado a uma amostra proporcional de 1.025 adolescentes matriculados na oitava série do primeiro grau e primeiro, segundo e terceiro anos do segundo grau, das escolas públicas e privadas do município estudado. O questionário continha questões sobre o uso de dez classes de substâncias psicoativas, questões demográficas e informações de validação, além de questões de percepção e comportamento intrínseco ao consumo de drogas. RESULTADOS: Da amostra 88,9% consumiram bebidas alcoólicas alguma vez na vida; 37,7% utilizaram o tabaco; 31,1% os solventes; 10,5% os medicamentos; 6,8% a maconha; 2,7% a cocaína; 1,6% os alucinógenos e 0,3% consumiu alguma substância a base de opiácios. As taxas de consumo cresceram com a idade, para todas as substâncias; no entanto, o uso de tabaco e de substâncias ilícitas mostrou uma desaceleração nos anos que compreendem o final da adolescência. Verificou-se que os meninos consumiram mais do que as meninas, exceto para os medicamentos, com as meninas consumindo barbitúricos, anfetaminas e tranqüilizantes em proporções semelhantes ou maiores que os meninos. A idade da primeira experiência mostrou que o acesso às substâncias psicoativas ocorreu em idades bastante precoces. CONCLUSÕES: As substâncias psicoativas, sejam lícitas ou ilícitas, são freqüentemente experimentadas na adolescência, tanto

  10. Consumo de substâncias psicoativas por adolescentes escolares de Ribeirão Preto, SP (Brasil. I - Prevalência do consumo por sexo, idade e tipo de substância

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    Muza Gilson M.

    1997-01-01

    Full Text Available INTRODUÇÃO: A preocupação suscitada quanto ao consumo de substâncias psicoativas pelos adolescentes tem mobilizado grandes esforços em todo o mundo na produção de conhecimento sobre este fenômeno. Decidiu-se estudar as taxas de prevalência de consumo de substâncias psicoativas de uso lícito e ilícito, sua distribuição por idade, sexo e a idade da primeira experiência com essas substâncias, entre adolescentes escolares do Município de Ribeirão Preto, SP, Brasil. MATERIAL DE MÉTODO: Um questionário devidamente adaptado e submetido a um teste de confiabilidade foi auto-aplicado a uma amostra proporcional de 1.025 adolescentes matriculados na oitava série do primeiro grau e primeiro, segundo e terceiro anos do segundo grau, das escolas públicas e privadas do município estudado. O questionário continha questões sobre o uso de dez classes de substâncias psicoativas, questões demográficas e informações de validação, além de questões de percepção e comportamento intrínseco ao consumo de drogas. RESULTADOS: Da amostra 88,9% consumiram bebidas alcoólicas alguma vez na vida; 37,7% utilizaram o tabaco; 31,1% os solventes; 10,5% os medicamentos; 6,8% a maconha; 2,7% a cocaína; 1,6% os alucinógenos e 0,3% consumiu alguma substância a base de opiácios. As taxas de consumo cresceram com a idade, para todas as substâncias; no entanto, o uso de tabaco e de substâncias ilícitas mostrou uma desaceleração nos anos que compreendem o final da adolescência. Verificou-se que os meninos consumiram mais do que as meninas, exceto para os medicamentos, com as meninas consumindo barbitúricos, anfetaminas e tranqüilizantes em proporções semelhantes ou maiores que os meninos. A idade da primeira experiência mostrou que o acesso às substâncias psicoativas ocorreu em idades bastante precoces. CONCLUSÕES: As substâncias psicoativas, sejam lícitas ou ilícitas, são freqüentemente experimentadas na adolescência, tanto

  11. EPICS device support module as ATCA system manager for the ITER fast plant system controller

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Paulo F., E-mail: pricardofc@ipfn.ist.utl.pt [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico – Universidade Técnica de Lisboa, Lisboa (Portugal); Santos, Bruno; Gonçalves, Bruno; Carvalho, Bernardo B.; Sousa, Jorge; Rodrigues, A.P.; Batista, António J.N.; Correia, Miguel; Combo, Álvaro [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico – Universidade Técnica de Lisboa, Lisboa (Portugal); Correia, Carlos M.B.A. [Centro de Instrumentação, Departamento de Física, Universidade de Coimbra, Coimbra (Portugal); Varandas, Carlos A.F. [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico – Universidade Técnica de Lisboa, Lisboa (Portugal)

    2013-10-15

    Highlights: ► In Nuclear Fusion, demanding security and high-availability requirements call for redundancy to be available. ► ATCA based Nuclear Fusion Systems are composed by several electronic and mechanical component. ► Control and monitoring of ATCA electronic systems are recommended. ► ITER Fast Plant System Controller Project CODAC system prototype. ► EPICS device support module as External ATCA system manager solution. -- Abstract: This paper presents an Enhanced Physics and Industrial Control System (EPICS) device support module for the International Thermonuclear Experimental Reactor (ITER) Fast Plant System Controller (FPSC) project based in Advanced Telecommunications Computing Architecture (ATCA) specification. The developed EPICS device support module provides an External System Manager (ESM) solution for monitoring and control the ITER FPSC ATCA shelf system and data acquisition boards in order to take proper action and report problems to a control room operator or high level management unit in case of any system failure occurrence. EPICS device support module acts as a Channel Access (CA) server to report problems and publish ATCA system data information to the control room operator, high level management unit or other CA network clients such as Control System Studio Operator Interfaces (CSS OPIs), Best Ever Alarm System Toolkit (BEAST), Best Ever Archive Utility (BEAUTY) or other CA client applications. EPICS device support module communicates with the ATCA Shelf manager (ShM) using HTTP protocol to send and receive commands through POST method in order to get and set system and shelf components properties such as fan speeds measurements, temperatures readings, module status and ATCA boards acquisition and configuration parameters. All system properties, states, commands and parameters are available through the EPICS device support module CA server in EPICS Process Variables (PV) and signals format. ATCA ShM receives the HTTP protocol

  12. Zespół napięcia przedmiesiączkowego – mit czy rzeczywistość = Premenstrual syndrome – myth or reality

    Directory of Open Access Journals (Sweden)

    Klaudia Pałucka

    2016-06-01

      Adres do korespondencji: Klaudia Pałucka Katedra i Klinika Ginekologii i Endokrynologii Ginekologicznej UM w Lublinie Al. Racławickie 23 20-049 Lublin, Poland tel./fax. 81-7183286 claudiapalucka@onet.pl Kierownik kliniki: prof. dr hab. n. med. L. Putowski   Streszczenie Wprowadzenie. W drugiej fazie cyklu miesiączkowego u większości kobiet pojawiają się dość specyficzne objawy natury somatycznej i psychicznej, które uznawane są za fizjologię. U 20-40% z nich mogą jednak świadczyć o patologii. Cel pracy. Celem pracy było wyjaśnienie, czym jest zespół napięcia przedmiesiączkowego, jak go rozpoznać oraz na czym polega pomoc chorej kobiecie. Materiał i metoda. Przy użyciu haseł przedmiotowych przeszukano uniwersytecką bazę danych, PubMed i MEDLINE. Przeszukanie elektroniczne ograniczono do prac w języku polskim i angielskim, opublikowanych w latach 2005-2015. Wyłoniono ogółem 55 pozycji (głównie lekarskich, z czego wykorzystano 34 oraz jedną ze strony internetowej Amerykańskiego Towarzystwa Położników i Ginekologów. Opis zebranego materiału. Z przeglądu piśmiennictwa wynika, że zespół napięcia przedmiesiączkowego to nie mit, lecz realny problem osobisty i medyczny. Zaburza funkcjonowanie kobiet w życiu społecznym i zawodowym. Rozpoznanie wymaga minimum dwumiesięcznej obserwacji objawów oraz wykluczenia innych chorób. Modyfikacja stylu życia i ewentualne leczenie farmakologiczne poprawiają samopoczucie i jakość życia kobiet. Przegląd piśmiennictwa ukazał dużą rozbieżność stanowisk autorów w omawianych kwestiach oraz zasugerował kierunki dalszych dociekań.   Słowa kluczowe: cykl miesiączkowy, zespół napięcia przedmiesiączkowego, dysforyczne zaburzenia przedmiesiączkowe.     Summary Introduction. Specific symptoms of somatic and psychological nature appear in the second phase of the menstrual cycle of many women. These symptoms are considered to be physiological, however, 20-40 % of them

  13. O que os pediatras conhecem sobre avaliação e tratamento da dor no recém-nascido? What do pediatricians know about pain assessment and treatment in newborn infants?

    Directory of Open Access Journals (Sweden)

    Aurimery G. Chermont

    2003-06-01

    Full Text Available OBJETIVO: analisar os conhecimentos dos pediatras que atuam com pacientes neonatais em relação à avaliação e o tratamento da dor do recém-nascido. MÉTODOS: estudo transversal com 104 pediatras (de um total de 110 que trabalhavam em 1999 a 2001, nas sete unidades de terapia intensiva e nos 14 berçários da cidade de Belém, e responderam a um questionário escrito com perguntas a respeito do seu perfil demográfico e do conhecimento de métodos de avaliação e de tratamento da dor no recém-nascido. RESULTADOS: cem por cento dos médicos referiram acreditar que o recém-nascido sente dor, mas apenas um terço deles conhecia alguma escala para avaliar a dor nessa faixa etária. A maioria dos entrevistados referia perceber a presença de dor no recém-nascido por meio de parâmetros comportamentais. O choro foi o preferido para avaliar a dor do bebê a termo; a mímica facial para o prematuro, e a freqüência cardíaca para o neonato em ventilação mecânica. Menos de 10% dos entrevistados diziam usar analgesia para punções venosas e capilares; 30 a 40% referiam empregar analgesia para punções lombares, dissecações venosas, drenagens de tórax e ventilação mecânica. Menos da metade dos entrevistados referiu aplicar medidas para o alívio da dor no pós-operatório de cirurgia abdominal em neonatos. O opióide foi o medicamento mais citado para a analgesia (60%, seguido pelo midazolam (30%. CONCLUSÃO: os pediatras demonstraram pouco conhecimento a respeito dos métodos de avaliação e tratamento da dor no período neonatal. Há necessidade de reciclagens e de atualização no tema para os profissionais de saúde que atuam com recém-nascidos doentes.OBJECTIVE: to analyze the knowledge of pediatricians who work with neonatal patients regarding the evaluation and treatment of pain in newborn infants. METHODS: cross-sectional study of 104 pediatricians (out of 110 who were working during 1999 to 2001 in seven intensive care units

  14. Asyndetic sentences with a concretiser

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    Tanasić Sreto Z.

    2015-01-01

    second clauses concretisers with conclusive, exclusive, temporal, adversative, causal, concessive, manner, spatial, gradational, respective and explanatory meanings. An array of subtypes occur within some of the types, depending on what semantic relation between the clauses is assigned by the concretisers. Finally, it is woth noting that this paper has more consistently solved the problem of exclusive and conclusive clauses as well. It is not well founded to place them among compound sentences because those sentences have their own conjunctions, whereas these are without conjunctions; it is also not well founded to classify them within some types of compound sentences because some of their classes stand out on account of characteristical conjunctions. Conclusive and exclusive clauses, as the paper demonstrates, are two types of asyndetic sentences with concretisers, the kind better represented in Serbian and which, in their entirety, are a model of asyndetic sentences. [Projekat Ministarstva nauke Republike Srbije, br. 178021: Opis i standardizacija savremenog srpskog jezika

  15. Otkaz hidrauličkog sistema čekića kao posledica kontaminacije čvrstim česticama

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    Mitar T. Jocanović

    2014-02-01

    Full Text Available Hidraulični sistemi mobilnih mašina su često kontaminirani čvrstim česticama. Čvrste čestice povećavaju intenzitet abrazivnog habanja hidrauličnih komponenata, i čine jednim od glavnih uzročnika otkaza sistema. U radu je dat prikaz reprezentativnog primera uticaja čvrstih čestica na povećano habanje delova hidrauličnog čekića bagera u eksploatacionim uslovima bagera u cementnoj industriji. Uvod Kontaminacija radnog fluida hidrauličnog sistema, jedan je od najvećih neprijatelja mobilnih mašina. Na mobilnim mašinama, koje se obično koriste u kontaminiranoj sredini, potrebno je pravilnim projektovanjem zaštititi hidraulični sistem posebno od eksterne kontaminacije. Uticaj kontaminanata na rad i pouzdanost hidrauličnih komponenata, a time i hidrauličnih sistema, može značajno da smanji planirani eksploatacioni vek. U radu je dat prikaz uticaja kontaminacije radnog fluida hidrauličnog sistema bagera preko radnog dela, hidrauličnog čekića. Uočeno je da zbog loše konstrukcije čekića i nepravilnog izbora povratnog filtera u hidrauličnom sistemu bagera,  u toku rada dolazi do prodora kontaminanata u vidu čvrstih čestica koje dovode do povećanja habanja radnih delova hidrauličnih komponenata (prvenstveno pogonske hidraulične pumpe kao i radnih delova hidrauličnog čekića. Da bi se shvatio uticaj kontaminacije hidrauličnog ulja čvrstim česticama, u radu je priložena foto-dokumentacija kritičnih delova pojedinih komponenti koje su oštećene. Takođe, izvršena je ekonomska analiza koja ukazuje na potrebu da se na mobilnim mašinama izvrši adekvatno filtriranje hidrauličnog fluida. Opis rada hidrauličnog sistema čekića Dat je opis jednog radnog ciklusa hidrauličnog čekića. Radni proces izazivanja udaraca čekićem zahteva kontinualno ponavljanje prethodno opisanog ciklusa. Iz navedenog se vidi da je rad hidrauličnog čekića veoma dinamičan ciklus kretanja određenih delova čekića, koji da bi

  16. Analgesia controlada pelo paciente com fentanil e sufentanil no pós-operatório de reconstrução de ligamentos do joelho: estudo comparativo Analgesia controlada por el paciente con fentanil o sufentanil en el pós-operatorio de reconstrucción de ligamentos de la rodilla: estudio comparativo Patient controlled analgesia with fentanyl or sufentanil in the postoperative period of knee ligament reconstruction: comparative study

    Directory of Open Access Journals (Sweden)

    Marcelo Negrão Lutti

    2002-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os opióides têm sido utilizados por via peridural associados ou não a anestésicos locais para analgesia pós-operatória de forma contínua e/ou em bolus controlado pelo paciente. O objetivo deste estudo foi comparar a analgesia pós-operatória entre o fentanil e sufentanil em infusão contínua e em bolus por via peridural, em pacientes submetidos à reconstrução de ligamento do joelho. MÉTODO: Participaram do estudo 70 pacientes com idades entre 16 e 47 anos, estado físico ASA I e II, divididos aleatoriamente em dois grupos: Grupo F (fentanil e Grupo S (sufentanil. Todos os pacientes foram submetidos à anestesia peridural com bupivacaína a 0,5% (100 mg com epinefrina 1:200.000 associada a fentanil (100 mg. Ao final da cirurgia, os pacientes receberam fentanil (Grupo F ou sufentanil (Grupo S por via peridural em regime de infusão contínua mais bolus liberados pelo paciente. No Grupo F foi utilizada solução fisiológica (85 ml contendo fentanil 500 µg (10 ml e bupivacaína (5 ml a 0,5%. No Grupo S foi utilizada solução fisiológica (92 ml contendo sufentanil 150 µg (3 ml e bupivacaína (5 ml a 0,5%. Para os dois grupos a bomba de infusão foi programada inicialmente em 5 ml.h-1, com dose de 2 ml em bolus liberado pelo paciente num intervalo de 15 minutos. Foram comparados os seguintes parâmetros: dor, número de bolus acionados, consumo de opióides, bloqueio motor, sedação e efeitos colaterais. RESULTADOS: Não houve diferença entre os grupos quanto à qualidade da analgesia, sendo a maioria de boa qualidade (EAV 0 a 2. Houve diferença quanto ao número de bolus liberados. No Grupo F solicitou mais bolus que o Grupo S. Não houve diferença quanto ao volume total e tempo de infusão total. Não houve bloqueio motor após a instituição da analgesia controlada pelo paciente. A incidência de vômitos e retenção urinária foi maior no Grupo S e quanto à sedação e ao prurido, não houve

  17. Avaliação algimétrica por estímulo nociceptivo térmico e pressórico em cães pré-tratados com levomepromazina, midazolam e quetamina associados ou não ao butorfanol ou buprenorfina The algimetry evaluation for thermic and pressoric nociceptive stimulus in pre treated dogs with methotrimeprazine, midazolam and ketamine associated or not with butorphanol or buprenorphine

    Directory of Open Access Journals (Sweden)

    André Leguthe Rosa

    2005-02-01

    Full Text Available OBJETIVO: Quantificar a dor em cães sob anestesia dissociativa através de estímulo térmico e pressórico e o período hábil de dois analgésicos opióides. MÉTODOS: Empregaram-se 30 cães alocados em três grupos (n=10, onde os animais de GI receberam levomepromazina e midazolam associado na mesma seringa à quetamina. Os animais de GII receberam o mesmo tratamento de GI porém associado ao butorfanol e por fim os animais de GIII receberam o mesmo tratamento de GI associando-se a buprenorfina. Procedeu se a avaliação paramétrica rotineira, empregando-se, entretanto, a termoalgimetria mensurada em °C em média de 52°C e a pressoalgimetria em kg. RESULTADOS: Na termoalgimetria houve diferença significativa em GI nos momentos M0 e M1,e em M4 e M5. Em GII houve diferença em M0, M1, M5 e M6. Em GIII houve diferença entre momentos M0 e M1. Na pressoalgimetria houveram diferenças em GI em diferentes momentos: M0, M2 e M3. Em GII observaram-se diferenças em todos os momentos. Em GIII observaram-se diferenças em M0 e M9. Ocorreram diferenças entre os grupos, sendo o M2 de GII menor que GI e GIII. Já em M4 e M5 de GIII demonstrou-se maior que GI e GII. E na avaliação dos períodos observou-se um período de latência significativamente maior em GI, porém com período hábil e de recuperação menor em relação à GII e GIII. Já a recuperação do tônus postural foi maior em GIII seguido de GII e finalmente de GI. CONCLUSÃO: O método empregado para mensuração do estímulo álgico foi eficiente, observando-se um período hábil analgésico de 3 horas para o butorfanol e de 6 horas para a buprenorfina.PURPOSE: This study aimed at quantifies the pain in dogs under dissociative anesthesia, across thermal and pressoric stimulus and quantify the reasonable period between two different opioids analgesics. METHODS: In this study, 30 dogs were used and, divided into three groups of 10 animals each, in which the animals of GI received

  18. Analgesia pós-operatória multimodal em cirurgia ginecológica videolaparoscópica ambulatorial: comparação entre parecoxib e tenoxicam Analgesia pos-operatoria multimodal en cirugía ginecológica videolaparoscópica ambulatorial: comparación entre parecoxib y tenoxican Multimodal analgesia in outpatient videolaparoscopic gynecologic surgery: comparison between parecoxib and tenoxicam

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    Sérgio D. Belzarena

    2005-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Avaliar as características da analgesia pós-operatória em pacientes submetidas à cirurgia ginecológica videolaparoscópica ambulatorial, comparando o efeito de parecoxib e tenoxicam venoso em um estudo duplamente encoberto. MÉTODO: Foram estudadas, prospectivamente, 60 pacientes divididas aleatoriamente em 2 grupos. Todas receberam sedação pré-operatória com midazolam. Um dos grupos (P recebeu, antes de iniciar a cirurgia, 40 mg de parecoxib e o outro (T 20 mg de tenoxicam. Na sala de operação foi feita raquianestesia com bupivacaína e sufentanil. A analgesia pós-operatória foi avaliada mediante a intensidade da dor com escalas verbal e visual, a localização da dor (incisional, visceral, no ombro e o consumo de analgésicos suplementares. Os efeitos colaterais adversos foram registrados. A satisfação da paciente com a técnica foi pesquisada. RESULTADOS: A qualidade analgésica foi excelente, com 76% das pacientes do grupo P e 83% das pacientes do grupo T sem queixa de dor nem uso de analgésicos no pós-operatório. Não houve diferença entre os grupos em todos os critérios e períodos de avaliação analgésica. A incidência de efeitos adversos foi pequena, embora prurido de intensidade leve e curta duração tenha ocorrido freqüentemente. Todas as pacientes ficaram satisfeitas ou muito satisfeitas com a técnica empregada. CONCLUSÕES: Uma técnica de analgesia multimodal, com um componente de anestésico local e opióide por via subaracnóidea associado a AINE venoso, produz analgesia pós-operatória de excelente qualidade com poucos efeitos colaterais adversos em cirurgia videolaparoscópica ginecológica ambulatorial. A escolha do AINE não parece importante para obter estes resultados.JUSTIFICATIVA Y OBJETIVOS: Evaluar las características de la analgesia pos-operatoria en pacientes sometidas a cirugía ginecológica videolaparoscópica ambulatorial, comparando el efecto de parecoxib y

  19. Telemonitorização domiciliária de insuficientes respiratórios crónicos graves e de doentes asmáticos

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    Manuela Zamith

    2009-05-01

    Full Text Available Resumo: Durante nove meses avaliámos um dispositivo portátil para transferência de dados pela Internet entre doentes e profissionais de saúde: oximetria, ECG, respostas a questionários e mensagens. Foram incluídos 51 insuficientes respiratórios crónicos (IRC graves acompanhados no Hospital de Pulido Valente (Lisboa e no Hospital do Espírito Santo (Évora e 21 asmáticos deste último hospital. A utilização e a aceitação deste dispositivo foram avaliadas através de questionários que registaram a opi-nião dos doentes e dos profissionais de saúde. Nos IRC de Lisboa avaliou-se a repercussão deste programa sobre internamentos hospitalares e qualidade de vida dos doentes.Aprender a utilizar o sistema foi mais difícil para os doentes IRC; a maioria (80% teve problemas com o equipamento, qualificados como raros/ocasionais em 62% dos casos.Para 31 doentes IRC seguidos no hospital de Lisboa, a utilização do sistema foi classificada como correcta em12 doentes, incorrecta em 7 e razoável em12 doentes. Os primeiros tiveram redução do número e duração dos internamentos em relação a igual período anterior ao programa de telemonitorização e melhoria da qualidade de vida, em particular no domínio da actividade. Com este sistema de telemonitorização 80% dos doentes IRC sentiram-se mais/muito mais apoiados e 33 (75% utilizariam este sistema no futuro, se ele estivesse disponível. No grupo de doentes asmáticos, 81% gostariam de manter este tipo de vigilância. O serviço foi considerado útil pelos investigadores. Concluímos que a telemonitorização domiciliária constitui uma contribuição positiva para a gestão dos doentes crónicos e a sua divulgação deverá ser considerada no futuro.Rev Port Pneumol 2009; XV (3: 385-418 Abstract: For 9 months we evaluated a portable device to transfer patient-clinician data by

  20. Świadomość i przekonania ojców na temat współczesnych zagrożeń i bezpieczeństwa dzieci = The awareness and conviction of the fathers on contemporary risks and safety of children

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    Jan Urmański

    2017-02-01

    1Department of Emotion and Motivation Psychology, The John Paul II Catholic University of Lublin   STRESZCZENIE   Wprowadzenie: Współcześnie obserwuje się coraz bardziej zróżnicowane niebezpieczeństwa i zagrożenia, na które narażone są dzieci. Troska ze strony rodziców jest kluczowym czynnikiem chroniącym bezpieczeństwo dzieci. Szczególne znaczenie w wychowaniu i ochronie dzieci ma aktywna postawa ojców. Cel pracy: Zbadać świadomość oraz przekonania ojców na temat współczesnych zagrożeń i bezpieczeństwa dzieci i młodzieży. Zanalizować stan wiedzy ojców co do potencjalnych zagrożeń oraz stopień ich zaangażowania w wychowywanie dzieci. Materiał i metoda: Przeprowadzone zostało badanie ankietowe na grupie 439 ojców posiadających co najmniej jedno dziecko poniżej 18 roku życia. Została opracowana specjalna ankieta badawcza składającą się z 11 pytań, w tym trzech otwartych, oraz metryczki stanowiącej opis podstawowych cech społeczno-demograficznych respondenta. Wyniki: Wyniki badań wskazały na istotne różnice pomiędzy grupą ojców reprezentujących próbę ogólnopolską a tzw. aktywnymi, wyróżniającymi się większym zaangażowaniem w wychowywanie dzieci. Wnioski: Do kluczowych wniosków należy przede wszystkim wskazanie przez 94% ojców aktywnych przekonania co do wpływu na bezpieczeństwo dzieci. O 33% mniej ojców z grupy ogólnopolskiej zadeklarowało takie przekonanie. Można wnioskować, że aktywna postawa względem bycia ojcem silnie koreluje z poczuciem sprawczości. Ponadto ojcowie reprezentujący próbę ogólnopolską wskazują na inne źródła niebezpieczeństw niż ojcowie tzw. aktywni, w których ocenie pierwotnym źródłem niebezpieczeństwa dla młodego pokolenia jest brak silnej relacji rodzic – dziecko.   Słowa kluczowe: współczesne zagrożenia, bezpieczeństwo dzieci, zaangażowane ojcostwo   ABSTRACT Introduction: Today observed increasingly diverse dangers and threats to which

  1. Ropivacaína isolada e associada ao fentanil ou ao tramadol administrados pela via peridural em cães Ropivacaine individually and in combination with fentanyl or tramadol, administered by peridural via in dogs

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    Bruno Monteiro da Silva

    2008-11-01

    Full Text Available A anestesia peridural é amplamente difundida no meio veterinário, utilizando-se o anestésico local isolado ou associado aos opióides, capazes de promover aumento do efeito analgésico. O objetivo deste estudo foi avaliar a função cardiorrespiratória e analgésica da ropivacaína isolada ou associada ao fentanil ou tramadol. Para tanto, oito cães foram tranqüilizados com acepromazina, submetidos à anestesia peridural com um dos seguintes protocolos: GR (ropivacaína, GRF (ropivacaína + fentanil, GRT (ropivacaína + tramadol, em volume total de 0,25ml kg-1, e foram avaliados os parâmetros: freqüência cardíaca e respiratória, temperatura retal, pressão arterial sistólica, e gasometria do sangue arterial, os bloqueios sensitivo e motor, o grau de sedação e a ocorrência de possíveis efeitos indesejáveis. A diminuição da freqüência cardíaca nos grupos GRF e GRT foi mais intensa e ocorreu hipotermia significativa no GRF. Foi evidenciada sedação severa em GRF e GRT. O período de recuperação foi mais curto nos animais de GRT. O GRT foi o grupo que apresentou bloqueio mais cranial. Foram observadas bradicardia, hipotermia e síndrome de Shiff-Sherrington no período trans-anestésico em animais de todos os grupos. Nas 24 horas de período pós-anestésico, não foram evidenciados efeitos indesejáveis nos grupos. O GRF apresentou maior duração de anestesia e analgesia, enquanto que o GRT apresentou a menor duração de anestesia com analgesia intermediária e o GR apresentou duração intermediária, com menor analgesia. Não foram encontradas alterações respiratórias e hemogasométricas, porém, bradicardia, hipotermia e síndrome de Schiff-Sherrington, alterações trans-anestésicas comuns na anestesia peridural foram encontradas.Peridural anesthesia is broadly applied in the Veterinary field, using the isolated local anesthetic or in combination with opiates capable to increase the analgesic effect. This research

  2. Hemogasometria e variáveis cardiopulmonares após administração do butorfanol em cães anestesiados pelo desfluorano sob ventilação espontânea Acid-base and cardiopulmonary effects after butorphanol administration in spontaneously breathing dogs anesthetized by desflurane

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    Paulo Sérgio Patto dos Santos

    2007-04-01

    Full Text Available Este experimento teve por objetivos avaliar as possíveis alterações cardiopulmonares e hemogasométricas decorrentes do uso do butorfanol em cães submetidos à anestesia pelo desfluorano sob ventilação espontânea. Para tal, foram utilizados vinte cães adultos, clinicamente saudáveis, pesando 12±3kg. Os animais foram distribuídos igualmente em dois grupos, GS e GB, e induzidos à anestesia com propofol (8,4±0,8mg kg-1, IV, intubados e submetidos à anestesia inalatória pelo desfluorano (10V%. Decorridos 40 minutos da indução, foi administrado aos animais do GS 0,05mL kg-1 de solução fisiológica a 0,9% (salina, enquanto que, no GB, foi aplicado butorfanol na dose de 0,4mg kg-1, ambos pela via intramuscular. As observações das variáveis freqüências cardíaca (FC e respiratória (f, pressões arteriais sistólica (PAS, diastólica (PAD e média (PAM, pH arterial (pH, pressão parcial de oxigênio no sangue arterial (PaO2, pressão parcial de dióxido de carbono no sangue arterial (PaCO2, déficit de base (DB, bicarbonato (HCO3 e saturação de oxigênio na hemoglobina (SatO2 tiveram início imediatamente antes da aplicação do opióide ou salina (M0. Novas mensurações foram realizadas 15 minutos após a administração do butorfanol ou salina (M15 e as demais colheitas foram realizadas a intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75. Os dados numéricos dessas variáveis foram submetidos à Análise de Perfil (PThe cardiopulmonary and acid-base effects of butorphanol in desflurane anesthetized dogs breathing spontaneously were evaluated. Twenty adult healthy, male and female dogs were used. They were separated into two groups of 10 animals each (GS and GB. Anesthesia was induced with propofol (8.4±0.8mg kg-1 IV and maintained with desflurane (10V%. After 40 minutes of induction, the animals from GS received saline solution at 0.9% (0.05mL kg-1 and from GB received butorphanol (0.4mg kg-1

  3. Palenie papierosów w ciąży = Cigarette smoking in pregnancy

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    Agnieszka Konstancja Pawłowska-Muc

    2016-01-01

    4 Doctoral Candidate at the Department and Clinic of Gynaecology and Gynaecological Endocrinology, School of Health Studies, Medical University of Lublin, Al. Racławickie 23   Adres do korespondencji: mgr piel. Agnieszka Konstancja Pawłowska-Muc Ośrodek Kształcenia Podyplomowego Pielęgniarek i Położnych Radomski Szpital Specjalistyczny im. dr Tytusa Chałubińskiego w Radomiu, ul. Lekarska 4 tel. 48  3615616; fax: 48 3615437 e-mail: agmich@vp.pl   Streszczenie Wprowadzenie. Palenie papierosów jest dużym problemem zdrowotnym i społeczno – ekonomicznym. Stanowi zagrożenie dla rozrodu, przebiegu ciąży i zdrowia dziecka. Cel pracy. Ukazanie problemu palenia papierosów przez kobiety ciężarne na podstawie przeglądu piśmiennictwa.             Skrócony opis stanu wiedzy. W opracowaniu przedstawiono epidemiologię i skalę problemu oraz konsekwencje palenia w okresie ciąży, z uwzględnieniem podziału na przebieg ciąży i zdrowie dziecka. Omówiono też świadomość kobiet odnośnie negatywnych skutków takich zachowań. Podsumowanie. Z przeglądu piśmiennictwa wynika, że palenie papierosów przez kobiety ciężarne nie należy do rzadkości. Skala problemu nie jest łatwa do oceny, gdyż wiele z nich po prostu nie przyznaje się do tego. Negatywne konsekwencje palenia w ciąży są dość liczne i dotyczą zarówno jej przebiegu, jak i stanu noworodka oraz zdrowia dziecka w późniejszym okresie życia. Istnieje potrzeba kształtowania postaw antynikotynowych, zwłaszcza wśród dziewcząt i kobiet w wieku rozrodczym.   Słowa kluczowe: kobieta ciężarna, palenie papierosów w ciąży.                                                                   Summary Introduction. Smoking cigarettes is a major health and social-economical problem. It poses a threat to reproduction, parturition and the health of the baby. Aim. Illustrating the problem of smoking cigarettes by

  4. Składniki mineralne w orzechach występujących w składzie „mieszanek studenckich” = Minerals in nuts which are components of „Trail Mix”

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    Natalia Mikołajczak

    2016-09-01

    Wydział Nauki o Żywności, Uniwersytet Warmińsko-Mazurski w Olsztynie   Uniwersytet Warmińsko-Mazurski w Olsztynie, Katedra Przetwórstwa i Chemii Surowców Roślinnych Pl. Cieszyński 1, 10-726 Olsztyn e-mail: natalia.mikolajczak@uwm.edu.pl   Streszczenie   Wprowadzenie i cel pracy: Orzechy stanowią cenną grupę żywności pod względem wartości żywieniowej, dlatego też są jednym z głównych składników wykorzystywanych w produkcji mieszanek studenckich. Obecność orzechów w codziennej diecie konsumenta ma pozytywny wpływ na organizm poprzez redukcję poziomu cholesterolu we krwi, przeciwdziałanie nowotworom i cukrzycy czy również wspomaganie utraty masy ciała. Wszystkie te korzyści wynikają ze składu chemicznego orzechów i obecności w nich wielu wartościowych składników odżywczych, w szczególności składników mineralnych. Celem pracy był przegląd aktualnego piśmiennictwa na temat zawartości poszczególnych składników mineralnych w orzechach, będących składnikami tradycyjnych mieszanek studenckich, czyli laskowych, włoskich, arachidowych, nerkowcach oraz migdałach. Skrócony opis stanu wiedzy: Orzechy to cenne źródło składników mineralnych, zarówno mikro, jak i makroelementów. Przede wszystkim, orzechy laskowe, włoskie, arachidowe oraz migdały dostarczają znacznych ilości potasu, którego zawartość w 100 g surowca odnotowuje się na poziomie wyższym niż 500 mg. Z kolei zawartość fosforu obecna jest na zbliżonym poziomie jedynie w migdałach. Mikroelementy takie jak żelazo, miedź, cynk i mangan występują we wszystkich orzechach w ilości 5-10 mg/100 g. Podsumowanie: Zebrane dane literaturowe potwierdzają fakt, że analizowane rodzaje orzechów są cennym źródłem zarówno mikro, jak i makroelementów. Są one bogactwem potasu, fosforu, magnezu oraz wapnia. Ponadto, dostarczają także znacznych ilości żelaza, cynku oraz manganu.   Słowa kluczowe: składniki mineralne, orzechy laskowe, orzechy

  5. A sedação e analgesia de crianças submetidas à ventilação mecânica estariam sendo superestimadas? Sedation and analgesia in children submitted to mechanical ventilation could be overestimated?

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    Ana Sfoggia

    2003-08-01

    Full Text Available OBJETIVO: descrever o perfil de uso de analgésicos e sedativos em crianças submetidas à ventilação mecânica, internadas em uma UTI pediátrica de referência, em um período de 12 meses, avaliando o tempo de uso dessas drogas, as doses diárias utilizadas e a incidência de síndrome de abstinência. MÉTODOS: estudo de coorte prospectivo (abril de 2001 a março de 2002, envolvendo crianças em ventilação mecânica (via tubo traqueal por um período superior a 12 horas, com idade entre 30 dias e 15 anos, que tivessem sucesso no processo de extubação (excluídos os óbitos ou aqueles que necessitassem reintubação. Uma equipe não envolvida com a assistência coletava os dados diariamente, até o 28º dia de ventilação mecânica (tempo máximo de seguimento para aqueles que eventualmente permanecessem um tempo superior a 28 dias em ventilação artificial, sendo o principal desfecho a dose, infundida às 12h da manhã, de morfina, fentanil, quetamina e midazolam (assumindo esta como a dose média naquele dia para cada uma destas drogas. O diagnóstico de síndrome de abstinência foi definido através de pesquisa no prontuário (registro do diagnóstico ou tomada de medidas terapêuticas neste sentido e por entrevista com o médico assistente de cada paciente, realizada nos dias subseqüentes à extubação. A pesquisa foi aprovada pelo Comitê de Ética e Pesquisa do HSL-PUCRS. RESULTADOS: dos 127 pacientes elegíveis para este estudo, obtivemos dados de 124 pacientes (16,0+29,5 meses, 58% meninos; 92 definidos como clínicos e 32 como cirúrgicos. Cada criança utilizou uma média de 1,7 sedativos-analgésicos em infusão por dia (sem diferença entre pacientes clínicos e cirúrgicos. Os opióides (morfina e fentanil foram as drogas mais utilizadas em ambos grupos (fentanil o preferido entre os clínicos, e a morfina entre os cirúrgicos, pOBJECTIVE: to describe the pattern of analgesic and sedative infusions in children submitted

  6. Specyficzne warianty języków narodowych: polski północnokresowy i niemiecki nadwołżański. Perspektywy badań porównawczych

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    Jolanta Mędelska

    2015-12-01

    . In the Soviet period, a peculiar cultural dialect developed, based on the dialects of Volga German. The author discusses the points of contact and divergence in the history of Volga German and Polish Northern Kresy dialect, indicating possible directions for comparative research.   Specyficzne warianty języków narodowych: polski północnokresowy i niemiecki nadwołżański. Perspektywy badań porównawczych Autorka zajmuje się szczególnymi kodami językowymi: polszczyzną północnokresową i niemczyzną nadwołżańską. Są to odmiany języków narodowych, które rozwijały się w niezwykłych warunkach. Oba znajdowały się poza terytorium etnicznym i występowały głównie w postaci rozległych wysp językowych. Polszczyzna północnokresowa ukształtowała się na ziemiach dzisiejszej Litwy, Białorusi, Łotwy w dwóch odmianach. Polacy dobrowolnie przenoszący się do miast i miasteczek Wielkiego Księstwa Litewskiego przenieśli na te tereny język polski, który z czasem przejmowały miejscowe warstwy wyższe, polonizując się i wytwarzając specyficzny miejscowy dialekt kulturalny. W II połowie XIX w. dialekt ten zaczęli przejmować chłopi litewscy i białoruscy. W ten sposób powstały zwarte obszary języka polskiego za północno-wschodnią granicą etniczną, czyli gwary północnokresowe. Obie odmiany polszczyzny rozwijały się w Imperium Rosyjskim, gdzie poddawane były rusyfikacji. Ponownie trafiły w orbitę silnego oddziaływania języka rosyjskiego po II wojnie światowej. W Litewskiej Socjalistycznej Republice Radzieckiej na ich podstawie ukształtował się nowy północnokresowy dialekt kulturalny. Dialekty niemieckie Powołża należą do gwar przeniesionych, trafiły nad Wołgę w XVIII w. wraz z przybyszami z różnych stron Niemiec, na nowym miejscu uległy modyfikacji, polegającej głównie na wymieszaniu poszczególnych gwar. Długo rozwijały się w izolacji zarówno od rosyjskiego otoczenia, jak i od innych odmian j

  7. Iliohypogastric/ilioinguinal nerve block in inguinal hernia repair for postoperative pain management: comparison of the anatomical landmark and ultrasound guided techniques

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    Abdurrahman Demirci

    2014-09-01

    ultrassom e a de marcos anatômicos para o manejo da dor no pós-operatório em casos de herniorrafia inguinal em adultos. Métodos: Foram randomicamente divididos 40 pacientes, estado físico ASA I-II, em dois grupos iguais: nos grupos AN (técnica de marcos anatômicos e US (técnica guiada por ultrassom, o bloqueio dos nervos ílio-hipogástrico/ilioinguinal foi feito com 20 mL de levobupivacaína a 0,5% antes da cirurgia com as técnicas especificadas. Escore de dor na avaliação pós-operatória, tempo de primeira mobilização, tempo de internação hospitalar, escore de satisfação com a analgesia no pós-operatório, efeitos colaterais induzidos por opiáceos e complicações relacionadas ao bloqueio foram avaliados durante 24 horas de pós-operatório. Resultados: Escores EVA em repouso na sala de recuperação e todos os valores clínicos durante o acompanhamento foram significativamente menores no grupo ultrassom (p < 0,01 ou p < 0,001. Escores EVA em movimento na sala de recuperação e todos os valores clínicos durante o acompanhamento foram significativamente menores no grupo ultrassom (p < 0,001 em todos os tempos avaliados. Enquanto os tempos de internação e da primeira mobilização foram significativamente menores, os índices de satisfação com a analgesia foram significativamente maiores no grupo ultrasom (p < 0,05, p < 0,001, p < 0,001, respectivamente. Conclusão: De acordo com o nosso estudo, o bloqueio dos nervos ílio-hipogástrico/ilioinguinal guiado por US em herniorrafias inguinais em adultos proporciona uma analgesia mais eficaz e maior satisfação com a analgesia do que com a técnica de marcos anatômicos. Além disso, pode-se sugerir que a observação das estruturas anatômicas com a US pode aumentar o sucesso do bloqueio e minimizar as complicações relacionadas ao bloqueio. Keywords: Inguinal herniorrhaphy, Iliohypogastric/ilioinguinal nerve block, Ultrasound, Landmark, Postoperative pain management, Levobupivacaine

  8. Consumo de substâncias psicoativas por adolescentes escolares de Ribeirão Preto, SP (Brasil. I - Prevalência do consumo por sexo, idade e tipo de substância The consumption of psychoactive substances by adolescents in schools in an urban area of Southeastern region of Brazil. I - Prevalence by sex, age and kind of substance

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    Gilson M. Muza

    1997-02-01

    Full Text Available INTRODUÇÃO: A preocupação suscitada quanto ao consumo de substâncias psicoativas pelos adolescentes tem mobilizado grandes esforços em todo o mundo na produção de conhecimento sobre este fenômeno. Decidiu-se estudar as taxas de prevalência de consumo de substâncias psicoativas de uso lícito e ilícito, sua distribuição por idade, sexo e a idade da primeira experiência com essas substâncias, entre adolescentes escolares do Município de Ribeirão Preto, SP, Brasil. MATERIAL DE MÉTODO: Um questionário devidamente adaptado e submetido a um teste de confiabilidade foi auto-aplicado a uma amostra proporcional de 1.025 adolescentes matriculados na oitava série do primeiro grau e primeiro, segundo e terceiro anos do segundo grau, das escolas públicas e privadas do município estudado. O questionário continha questões sobre o uso de dez classes de substâncias psicoativas, questões demográficas e informações de validação, além de questões de percepção e comportamento intrínseco ao consumo de drogas. RESULTADOS: Da amostra 88,9% consumiram bebidas alcoólicas alguma vez na vida; 37,7% utilizaram o tabaco; 31,1% os solventes; 10,5% os medicamentos; 6,8% a maconha; 2,7% a cocaína; 1,6% os alucinógenos e 0,3% consumiu alguma substância a base de opiácios. As taxas de consumo cresceram com a idade, para todas as substâncias; no entanto, o uso de tabaco e de substâncias ilícitas mostrou uma desaceleração nos anos que compreendem o final da adolescência. Verificou-se que os meninos consumiram mais do que as meninas, exceto para os medicamentos, com as meninas consumindo barbitúricos, anfetaminas e tranqüilizantes em proporções semelhantes ou maiores que os meninos. A idade da primeira experiência mostrou que o acesso às substâncias psicoativas ocorreu em idades bastante precoces. CONCLUSÕES: As substâncias psicoativas, sejam lícitas ou ilícitas, são freqüentemente experimentadas na adolescência, tanto

  9. Używki w ciąży – kofeina = Stimulants in pregnancy – caffeine

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    Agnieszka Konstancja Pawłowska-Muc

    2015-06-01

    3 Independent Obstetric Skills Workshop, Medical University of Lublin, ul. Staszica 4/6   Adres do korespondencji: mgr piel. Agnieszka Konstancja Pawłowska-Muc Ośrodek Kształcenia Podyplomowego Pielęgniarek i Położnych Radomski Szpital Specjalistyczny im. dr Tytusa Chałubińskiego w Radomiu, ul. Lekarska 4 tel. 48  3615616; fax: 48 3615437 e-mail: agmich@vp.pl   Używki w ciąży - kofeina Streszczenie Wprowadzenie. Kofeina należy do substancji psychoaktywnych, ogólnodostępnych i najbardziej rozpowszechnionych na całym świecie. Jej wpływ na zdrowie kobiet, przebieg ciąży i rozwój płodu jest od lat przedmiotem wielu dyskusji, sporów i dociekań naukowych. Cel pracy. Przegląd piśmiennictwa na temat wpływu działania kofeiny na organizm kobiety oraz skutków jej spożywania w okresie ciąży i laktacji. Skrócony opis stanu wiedzy. Działanie kofeiny na organizm kobiety oraz jej wpływ na przebieg ciąży i zdrowie dziecka nie zostały dotychczas w pełni poznane. Znajduje się ona w wielu produktach, a to sprawia, że jej całkowite, dzienne spożycie jest trudne do oceny.             Podsumowanie. Z przeglądu piśmiennictwa wynika, że duży odsetek kobiet ciężarnych ma zwyczaj codziennego picia herbaty i/lub kawy z kofeiną. Zakres embriotoksycznego działania tej substancji zależy od jej dawki, częstości spożywania oraz stanu zdrowia kobiety ciężarnej. Stanowiska  autorów, co do stosowania napojów zawierających kofeinę w tym czasie, a także ich skutków, są podzielone. Większość jednak podziela pogląd, iż w ciąży i w okresie laktacji należy ograniczyć, a najlepiej zaniechać, spożywanie takich napojów. Zasadne jest zatem, aby działania promujące i wspierające zdrowy styl życia kobiet w wieku rozrodczym dotyczyły, między innymi, tej kwestii. Słowa kluczowe: kofeina, ciężarna, zdrowie, ciąża, płód.   Stimulants in pregnancy - caffeine Summary Introduction. Caffeine belongs to the group of

  10. Uso da metadona no tratamento da dor neuropática não-oncológica: relato de casos Uso de la metadona en el tratamiento del dolor neuropático no oncológico: relato de casos Methadone to treat non-oncologic neuropathic pain: case reports

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    Jeane Pereira da Silva Juver

    2005-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O relato inclui sete casos de pacientes com dor neuropática crônica não-oncológica que não haviam obtido resultados satisfatórios com os tratamentos clássicos com antidepressivos tricíclicos e anticonvulsivantes. O uso da metadona, opióide sintético, semelhante à morfina, por via oral, é referido como alternativa no tratamento da dor neuropática pela sua ação antagonista não-competitiva sobre os receptores NMDA. Este estudo tem como objetivo avaliar o uso da metadona no tratamento de pacientes portadores de dores crônicas de origem neuropática não-oncológica que não melhoraram com os tratamentos clássicos. RELATO DOS CASOS: São apresentados sete casos nos quais a dose de metadona foi titulada em consultas subseqüentes e as variáveis escore da intensidade álgica segundo a escala de faces, efeitos colaterais e melhora da capacidade funcional foram analisados no 1º, 7º, 14º, 30º e 180º dias após o início do uso da medicação. Houve redução do escore da intensidade álgica e a ocorrência de efeitos colaterais como constipação, sedação, náuseas, cefaléia e insônia. Não foram observados efeitos colaterais do tipo euforia, sudorese, mioclonias, retenção urinária, redução de libido e depressão respiratória. CONCLUSÕES: Os pacientes apresentaram resposta que foi considerada satisfatória ao uso da medicação, em baixas doses; controle dos efeitos colaterais com medidas simples e melhora representativa da capacidade funcional. A inclusão da metadona, nas condições deste estudo, mostrou-se uma opção eficaz, segura e de baixo custo, para o tratamento das dores de origem neuropáticas não-oncológicas.JUSTIFICATIVA Y OBJETIVOS: El relato incluye siete casos de pacientes con dolor neuropático crónico no oncológico, que no habían logrado resultados satisfactorios con los tratamientos clásicos con antidepresivos tricíclicos y anticonvulsivantes. El uso de la metadona

  11. Regularities in the Changes of Absorber Material Properties as a Function of Absorber Concentration; Regularite des Variations des Proprietes des Substances Absorbantes en Fonction de la Concentration de l'Absorbant; Zakonomernosti izmeneniya svojstv poglashchayushchikh materialov v zavisimosti ot kontsentratsii poglotitelya; Leyes de Variacion de las Propiedades de los Materiales Absorbentes en Funcion de la Concentracion del Absorbente

    Energy Technology Data Exchange (ETDEWEB)

    Portnoj, K. I.

    1964-06-15

    raboty v re akto r ah na teplovyh i promezhutochnyh nejtronah. Pogloshhajushhte materialy, soderzhashhie bor, naprimer boridy,obladajut nizkimi mehanicheskimi svojstvami, chto svjazano s osobennostjami ih kristallicheskoj struktury. M a terialy, soderzhashhie okisly redkozemel'nyh jelementov (samarij, evropij, gadolinij, disprozij idr.), dispergirovannye v matrice iz splava tipa nimonik ili v nerzhavejushhej stali znachitel'no izmenjajut mehanicheskie svojstva v zavisimosti ot koncentracii poglotitelja. Avtory vyskazali gipotezu ob obrazovanii maksimumo pogloshhajushhej sposobnosti pri vzaimnom legirovanii poglotitelej. Jeta gipoteza poluchila dal'nejshee podtverzhdenie opy tami s mnogimi metallicheskimi i nemetallicheskimi pogloshhajushhimi sistemami v reaktorah na teplovyh i promezhutochnyh nejtronah. (author)

  12. Profilaxia do prurido causado pela administração subaracnóidea de sufentanil: efeitos do droperidol, da nalbufina, do ondansetron e da combinação deles Profilaxis del prurito inducido por la administración subaracnoidea de sufentanil: influencia do droperidol, da nalbufina, do ondansetron y da combinacion de elles Prevention of itching after spinal sufentanil: effects of droperidol, nalbuphine, ondansetron and the association of them

    Directory of Open Access Journals (Sweden)

    André Kolm

    2006-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O uso espinhal de opióides pode causar alguns efeitos indesejáveis, dentre os quais, o mais freqüente é o prurido que, apesar de sua baixa morbidade, pode proporcionar desconforto intenso ao paciente e prolongar o período de internação. O objetivo deste estudo foi avaliar diversas opções terapêuticas no tratamento profilático do prurido após administração de sufentanil por via subaracnóidea. MÉTODO: Foram distribuídos de maneira aleatória, por sorteio, 100 pacientes a serem submetidos à intervenção cirúrgica não-obstétricas em cinco grupos, de acordo com o tratamento utilizado: controle (ausência de tratamento - C; droperidol 2,5 mg (D; nalbufina 10 mg (N; associação dos medicamentos anteriores (DN e ondansetron 8 mg (O. O prurido foi avaliado quantitativamente 30 minutos, 1, 2, e 3 horas após a administração subaracnóidea de sufentanil. RESULTADOS: Os grupos C e O apresentaram incidência significativamente maior de prurido em relação aos grupos D, N e DN. Entretanto, não houve diferença significativa na necessidade de tratamento específico com naloxona entre os grupos tratados. CONCLUSÕES: O tratamento profilático do prurido neste estudo, independentemente do fármaco utilizado, diminuiu sua intensidade e limitou a necessidade de tratamento específico com naloxona.JUSTIFICATIVA Y OBJETIVOS: El uso espinal de opioides puede ser causa de efectos indeseables, entre los que el prurito es el más frecuente y a pesar de su escasa morbilidad puede ser causa de intenso desconfort y prolongar el tiempo de internación. El objetivo de este estudio es evaluar diferentes opciones terapéuticas para la prevención del prurito que ocurre después de la administración subaracnoidea de sufentanil. MÉTODO: Cien pacientes que iban a recibir cirugías no obstétricas fueron divididos aleatoriamente (sorteo en 5 grupos de acuerdo al tratamiento preventivo usado: control (sin tratamiento, grupo C

  13. Riscos Empresariais Divulgados nas Ofertas Públicas de Ações no BrasilEnterprise Risk Disclosed in Initial Public Offering in BrazilRiesgos Empresariales Divulgados en las Ofertas Públicas de Acciones en Brasil

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    CUNHA, Paulo Roberto da

    2011-12-01

    IPO listed in the Brazilian Securities Commission (CVM in 2008. The sample consisted of 10 companies from various segments. We have adopted a criterion score by which it was found that the average percentage score achieved was 59% of disclosure. We have also defined indicators of the level of disclosure by risk category and by company. Within these categories, this percentage ranged from 42% of the category “risks of issuing” up to 85% in category “risks related to the shareholder”. As for the scores of companies, the lowest score was obtained by Le Lis Blanc, 51%, while the Vale do Rio Doce has obtained the highest score, 66% of the total possible. In conclusion, it was found that the level of disclosure of risks in stock offering prospectus is not yet satisfactory. Possible causes for this phenomenon are analyzed.RESUMENLa reglamentación vigente en Brasil determina que las empresas que desean captar recursos financieros el mercado de capitales mediante la emisión de acciones deberán elaborar un Prospecto de Oferta Pública de Acciones (OPI en el que deben informar, entre otras cosas, todos los riesgos que pueden afectar el negocio. El objetivo de este artículo es investigar el grado de exposición de los riesgos empresariales informados en estos prospectos. El diseño metodológico fue descriptivo con un enfoque cualitativo. El objeto de análisis consistió en los Prospectos Definitivos de Oferta Pública de Acciones, catalogados en la Comisión de Valores Mobiliarios (CVM en 2008. La muestra abarcó 10 empresas de diversos segmentos. Se adoptó un criterio de puntuación que permitió corroborar que el porcentaje medio de puntuación alcanzado fue del 59% de exposición. También se definieron indicadores del grado de exposición por categoría de riesgo y por empresa. Ese porcentaje osciló entre el 42% de la categoría “riesgos del emisor” hasta un 85% en la categoría “riesgos relacionados con el accionista.” En lo que se refiere a la

  14. Analgesia adjuvante e alternativa Analgesia adyuvante y alternativa Adjuvant and alternative analgesia

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    Nilton Bezerra do Vale

    2006-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Embora a dor aguda e a crônica sejam habitualmente controladas com intervenções farmacológicas, 14 métodos complementares de analgesia adjuvante e alternativa (AAA podem reduzir o uso e abuso na prescrição de analgésicos e diminuir os efeitos colaterais que eventualmente comprometem o estado fisiológico do paciente. CONTEÚDO: Todos os mecanismos antiálgicos atuam através da via espinal de controle da comporta de Melzack e Wall e/ou através da transdução do sinal nos sistemas de neurotransmissão e neuromodulação central relacionados com analgesia, relaxamento e humor: peptidérgico, monaminérgico, gabaérgico, colinérgico e canabinóide. A analgesia adjuvante complementar é habitualmente utilizada nos tratamentos fisiátricos, ortopédicos, reumatológicos, obstétricos e com acupuntura. A analgesia alternativa complementar pode potencializar os métodos analgésicos convencionais, a exposição à luz do sol matutino, luz e cores sob luz artificial, o tempo (T - anestésicos gerais mais potentes à noite, opióides de manhã e anestésicos locais à tarde, dieta, bom humor e riso, espiritualidade, religião, meditação, musicoterapia, hipnose e efeito placebo. CONCLUSÕES: Se a dor aguda é um mecanismo de defesa, a dor crônica é um estado patológico desagradável relacionado com a depressão endógena e a uma baixa qualidade de vida. É importante estabelecer relações interdisciplinares entre a Medicina adjuvante e alternativa nas terapias analgésicas e antiinflamatórias clássicas.JUSTIFICACIÓN Y OBJETIVOS: Aunque el dolor agudo y el crónico sean habitualmente controlados con intervenciones farmacológicas, 14 métodos complementarios de analgesia adyuvante y alternativa (AAA pueden reducir el uso y el abuso en la prescripción de analgésicos y disminuir los efectos colaterales que eventualmente comprometen el estado fisiológico del paciente. CONTENIDO: Todos los mecanismos anti

  15. Eficácia analgésica da dexmedetomidina comparada ao sufentanil em cirurgias intraperitoneais: estudo comparativo Eficacia analgésica de la dexmedetomidina comparada al sufentanil en cirugías intraperitoneales: estudio comparativo Analgesic efficacy of dexmedetomidine as compared to sufentanil in intraperitoneal surgeries: comparative study

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    Marco Aurélio Marangoni

    2005-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A dexmedetomidina, agonista alfa2-adrenérgico com especificidade alfa1:alfa2 1:1620, não determina depressão respiratória, sendo utilizada no intra-operatório como sedativo e analgésico. Esse fármaco tem sido empregado com os opióides em anestesia de procedimentos com elevado estímulo doloroso, como os abdominais intraperitoneais, não havendo referências sobre seu uso como analgésico único. Comparou-se a dexmedetomidina ao sufentanil em procedimentos intraperitoneais, de pacientes com mais de 60 anos de idade. MÉTODO: Foram estudados 41 pacientes divididos aleatoriamente em dois grupos: GS (n = 21, que recebeu sufentanil, e GD (n = 20, dexmedetomidina, ambos na indução e manutenção da anestesia. Os pacientes receberam etomidato (GS e GD com midazolam (GD na indução, isoflurano e óxido nitroso na manutenção da anestesia. Foram avaliados os atributos hemodinâmicos (pressão arterial média e freqüência cardíaca, tempos de despertar e de extubação ao final da anestesia, locais onde os pacientes foram extubados - sala de operação (SO ou sala de recuperação pós-anestésica (SRPA, tempo de permanência na SRPA, necessidade de analgesia suplementar e antiemético na SRPA, complicações apresentadas na SO e SRPA, índice de Aldrete-Kroulik na alta da SRPA e a necessidade de máscara de oxigênio na alta da SRPA. RESULTADOS: Não houve diferença quanto à estabilidade hemodinâmica e GD apresentou menor tempo de permanência na SRPA e menor necessidade de máscara de oxigênio na alta da SRPA. CONCLUSÕES: A dexmedetomidina pode ser utilizada como analgésico isolado em operações intraperitoneais em pacientes com mais de 60 anos, determinando estabilidade hemodinâmica semelhante à do sufentanil, com melhores características de recuperação.JUSTIFICATIVA Y OBJETIVOS: La dexmedetomidina, agonista alfa2-adrenérgico con especificidad alfa1:alfa2 1:1620, no determina depresión respiratoria

  16. Medicamentos de venta libre en el Brasil Over-the-counter drugs in Brazil

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    Isabela Heineck

    1998-06-01

    Full Text Available En el presente estudio se analizaron los 100 productos del mercado farmacéutico popular (de venta libre más vendidos en el Brasil, en el período comprendido entre junio de 1992 y junio de 1993. Se excluyeron 23 productos alimentarios clasificados como medicamentos. La muestra, formada por 77 medicamentos, representaba aproximadamente 67% del consumo en valores y 76,8% del consumo en unidades de las especialidades vendidas en el mercado popular. Para la clasificación de los medicamentos, se utilizó el sistema anatómico-terapéutico-químico (ATC. Las especialidades también se clasificaron con la metodología del valor intrínseco, que considera la eficacia y los riesgos de las mismas. La mayoría de las especialidades (91% mostraron "poco valor intrínseco" (dudoso/nulo, relativo, inaceptable, y 70% correspondieron a combinaciones en dosis fijas. Solo 10 especialidades pertenecían a la Relación Nacional de Medicamentos, producida por el Ministerio de Salud, y cuatro a la lista de medicamentos esenciales de la OMS. Los grupos terapéuticos a los que pertenecían las especialidades fueron, en orden de mayor a menor frecuencia, el aparato digestivo, la piel, el aparato genitourinario, el aparato musculosquelético, el sistema nervioso central, los antiparasitarios, el aparato respiratorio y los órganos de los sentidos. El subgrupo terapéutico de mayor venta fue el de preparaciones para la garganta, mientras que el que representó el mayor valor en ventas fue el de los analgésicos no opiáceos y antipiréticos. Los resultados confirman la hipótesis planteada de que los medicamentos de venta libre en el Brasil presentan mala calidad terapéutica y de que el consumo de muchas de estas especialidades farmacéuticas representa gastos innecesarios para la población. Se puede afirmar también que algunos de esos medicamentos no deberían estar disponibles para una población que no está al corriente de las complicaciones asociadas con su

  17. End-of-life care in COPD: A survey carried out with Portuguese Pulmonologists

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    C. Gaspar

    2014-05-01

    dos médicos indicaram que raramente iniciaram conversas sobre o fim de vida com os seus doentes com DPOC (48,5%. A maioria nunca/raramente sugeriram a toma de decisão sobre a utilização de ventilação mecânica invasiva (68,4%. As conversas foram descritas como ocorrendo, na sua maioria, durante/após uma exacerbação grave (53,7%. Apenas 37,5% dos participantes indicaram tratar a dispneia frequentemente/sempre com opiáceos. Apenas 9,6% indicaram que nunca/raramente trataram a ansiedade/depressão. A maioria dos participantes considerou a conversa sobre questões de fim de vida como sendo difícil/muito difícil (89,0%. Os motivos mais frequentemente indicados foram a sensação de que os doentes não estavam preparados para essa conversa (70,0%, medo de tirar a esperança aos doentes (58,0% e falta de formação (51,0%. Conclusão: A comunicação sobre o fim de vida entre o doente e os médicos na DPOC ainda não é suficientemente boa. A formação nesta área e a criação de protocolos formais para iniciar os cuidados em fim de vida foram identificados como fatores importantes a melhorar. Keywords: COPD, Palliative care, End-of-life, Communication, Palavras-chave: DPOC, Cuidados paliativos, Fim de vida, Comunicação

  18. Influência da naloxona e metisergida sobre o efeito analgésico do laser em baixa intensidade em modelo experimental de dor Influencia de la naloxona y la metisergida sobre el efecto analgésico del láser en baja intensidad en modelo experimental de dolor Influence of naloxone and methysergide on the analgesic effects of low-level laser in an experimental pain model

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    André Peres e Serra

    2010-06-01

    ; Luz no coherente; LPT + Naloxona y LPT + Metisergida. RESULTADOS: La fototerapia con láser en baja intensidad demostró ser un método analgésico eficaz, mientras que el uso de la fuente de luz no coherente no demostró poseer ningún efecto analgésico. El uso de naloxona bloqueó el efecto analgésico del LPT, mientras que el uso de metisergida no afectó la analgesia del LPT. CONCLUSIONES: La LPT en los parámetros utilizados tuvo un efecto analgésico. La analgesia de la LPT es mediada por receptores opióides periféricos. La LPT parece que no interactúa con los receptores serotoninérgicos periféricos.BACKGROUND AND OBJECTIVES: Although the mechanism of action of laser phototherapy (LPT is not known, it is a promising analgesic method. The aim of this study was to evaluate whether the action of LPT depends on the activation of peripheral opioid or serotonergic receptors. METHOD: Inflammatory pain was induced through the injection of carrageenin in the left posterior paw of male Wistar rats. The InGaAIP visible laser diode (660 nm with fluency of 2.5 J.cm-2 was used. Von Frey filaments were used to analyze mechanical hyperalgesia. Animals were separated into five groups: Carrageenin; Laser (LPT; Non-coherent light; LPT + Naloxone; and LPT + Methysergide. RESULTS: Low-Level Laser phototherapy proved to be an effective analgesic method, while non-coherent light did not show a similar effect. The use of naloxone blocked the analgesic effect of LPT, while methysergide did not affect LPT-induced analgesia. CONCLUSIONS: According to the parameter used in this study, LPT produced analgesia. Analgesia induced by laser phototherapy is mediated by peripheral opioid receptors. Laser phototherapy does not seem to interact with peripheral serotonergic receptors.

  19. Measurement of Small Values of Hydrostatic Pressure with the Compensation of Atmospheric Pressure Influence / Pomiar Małych Wartości Ciśnienia Hydrostatycznego Z Kompensacją Wpływu Ciśnienia Atmosferycznego

    Science.gov (United States)

    Broda, Krzysztof; Filipek, Wiktor

    2013-09-01

    structure has been simplified and the measurement accuracy has increased. Znajomość rozkładu ciśnienia (lub różnicy ciśnień) determinuje opis przepływu płynu przez ośrodek porowaty. W przypadku dużych liczb Reynoldsa nie nastręcza to większych trudności, lecz dla przepływów laminarnych (tj. dla liczb Re (Bear, 1988; Duckworth, 1983; Troskolański, 1957) z zakresu 0.01 do 3) jest to praktycznie niemożliwe w oparciu o dostępne na rynku przyrządy. Przyczyny powodujące taką sytuację zostały omówione w poprzednim opracowaniu (Broda i Filipek, 2012), w którym zwrócono uwagę na trudności pomiarów związane z napięciem powierzchniowym czy włoskowatością (Adamson, 1997). Zaproponowano (Broda i Filipek, 2012) nową, autorską metodę pomiaru bardzo małych różnic ciśnień oraz skonstruowano odpowiednie stanowisko składające się z dwóch oddzielnych zbiorników pomiarowych oraz przeprowadzono pomiary. Z przeprowadzonych badań (Broda i Filipek, 2012) wynikała konieczność zastosowania stabilizacji temperatury urządzenia oraz kompensacji wpływu ciśnienia atmosferycznego na proces pomiarowy. Niniejsza publikacja przedstawia wyniki kontynuacji badań nad metodami i aparaturą do pomiaru bardzo małych różnic ciśnień z uwzględnieniem zdobytych doświadczeń, w oparciu o nowe stanowisko pomiarowe, którego zasadę działania i budowę przedstawiono na rys. 1-5, kolejno przedstawiając koncepcję wykonania pomiaru małych wartości ciśnienia hydrodynamicznego z kompensacją wpływu ciśnienia atmosferycznego rys. 1; ilustrację obrazującą stan odpowiadający przypadkowi braku przepływu płynu przez badany obiekt rys. 2; omawiając stan odpowiadający przypadkowi przepływu płynu przez badany obiekt rys. 3. Kolejno omówiono stan odpowiadający pomiarowi spadku ciśnienia na badanym obiekcie rys. 4 oraz przedstawiono metodykę pomiaru (zależności (1) - (20)). Zdjęcie stanowiska badawczego oraz jego elementów ilustruje rys. 5. W

  20. „Słownik wyrazów obcego a mniej jasnego pochodzenia…” Jana Karłowicza – wyrazem wiedzy i zamiłowań lituanistycznych autora

    Directory of Open Access Journals (Sweden)

    Kristina Rutkovska

    2016-12-01

    same time, he documented Lithuanian realities, giving them detailed descriptions. He provided much to linguists researchers who intensively practiced typological and comparative linguistics of Lithuanian words in the nineteenth century, citing unknown tokens of direct contacts with Lithuanianism, not listed in the then existing collections of Lithuanian lexis (Kurschat, Nesselmann.   Słownik wyrazów obcego a mniej jasnego pochodzenia… Jana Karłowicza – wyrazem wiedzy i zamiłowań lituanistycznych autora Przedmiotem opisu w artykule jest leksyka litewska, występująca w Słowniku wyrazów obcego a mniej jasnego pochodzenia… (SWO Jana Karłowicza, który był zaangażo­wany w badania nad językiem i kulturą litewską wieloaspektowo – badał narzecza litewskie, nazwy miejscowe, inicjował badania nad folklorem litewskim. Publikował też materiały z Litwy (opisy etnograficzne, folklor, opis języka szlachty żmudzkiej w czasopiśmie „Wisła”, uprzednio je redagując i umieszczając w tekście komentarze do leksyki litewskiej. Jego zbiory onomastyczne, podobnie jak i studium O języku litewskim, zostało na nowo odkryte przez językoznawców litewskich, poświęcono im odrębne opracowania. Solidna wiedza z zakresu językoznawstwa porównawczego i własne doświadczenie badacza języka i kultury litewskiej, praca z litewskimi materiałami drukowanymi, rękopiśmiennymi czy też pochodzącymi z badań terenowych na Litwie pozwoliły mu na wykorzystanie tej wiedzy i materiałów w bardzo różnorodny sposób. Umieszcza on w dokumentacji do wyrazów analizowanych w SWO wyrazy pochodzenia litewskiego i obok – zapożyczenia słowiańskie do gwar litewskich, tym samym przyczyniając się pośrednio do badań nad leksyką obcą w gwarach litewskich. Taki sposób interpretacji historycznojęzykowych był do zaakceptowania w owych czasach, kiedy metodologia badań etymologicznych dopiero się kształtowała, a każdy przejaw języka był wart dokumentowania

  1. Zatrucie tlenkiem węgla – drogi narażenia, obraz kliniczny, metody leczenia = Carbon monoxide poisoning, routes of exposure, clinical manifestation, treatment

    Directory of Open Access Journals (Sweden)

    Magdalena Sowa

    2015-04-01

    3Wojewódzka Stacja Pogotowia Ratunkowego w Bydgoszczy   Adres do korespondencji: mgr Magdalena Sowa Katedra i Zakład Laseroterapii i Fizjoterapii Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy ul. Marii Skłodowskiej – Curie 9 85 – 094 Bydgoszcz e – mail: magdalena.sowa@cm.umk.pl   Streszczenie   Wprowadzenie: Tlenek węgla (CO jest bezbarwnym, bezwonnym, niedrażniącym i toksycznym gazem, niewykrywalnym przez narządy zmysłów. Powstaje on w wyniku niecałkowitego spalenia substancji, produktów zawierających węglowodory (np. gazy przemysłowe, węgiel drewno. Według badań stanowi jedną z najczęstszych przyczyn zatruć inhalacyjnych na świecie. Cel pracy: Celem pracy była analiza dróg narażenia, obrazu klinicznego oraz metod leczenia zatrucia tlenkiem węgla. Skrócony opis stanu wiedzy: Toksyczność tegoż związku jest silnie związana z jego wysokim powinowactwem do hemoglobiny (około 200 razy większe od tlenu. Strukturami najbardziej newralgicznymi i najbardziej narażonymi na działanie CO są serce i ośrodkowy układ nerwowy (OUN. Patomechanizm działania polega na wiązaniu się tlenku węgla z atomem żelaza w cząsteczce hemu, tworząc związek zwany karboksyhemoglobiną (COHb. Wentylacja powietrzem zwierającym CO wiedzie do hipoksji tkankowej czyli niedotlenienia. Zwolnieniu, a następnie zahamowaniu ulegają metaboliczne procesy oksydacyjne, dochodzi do akumulacji kwaśnych metabolitów, przyczyniających się do rozszerzenia tętnic mózgowych a w konsekwencji przekrwienia mózgu. Podsumowanie: Liczba zatruć tlenkiem węgla w Polsce jest znacznie większa niż w innych krajach Europy. W ostatnich latach zaobserwowano znaczny spadek śmiertelności spowodowanej zatruciem CO, jednakże nadal bardzo wysoki koszt zdrowotny, wyrażający się w tysiącach pacjentów tracących zdrowie  a nawet życie, skłania do dbałości o skuteczność  działań prewencyjnych.   S

  2. Causal-implicative relationships in the Serbian hypotaxis (Complex of generative complex sentences

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    Vojvodić Dojčil P.

    2015-01-01

    relations. In this way, “modus-dictum” relationships are realized in concessive sentences, because in a certain sense a subordinate clause (with a propositional frame - modus interprets the contents of a main clause (proposition - dictum. The author emphasizes a special role of a referral (either explicit or implicit to the source and credibility of the information communicated by the addresser, whereby the source can be presented by both observations and gained experience of the addresser (direct evidentiality as well as other people, or logical reasoning which is based on his/her own beliefs and assumptions (indirect evidentiality. Statistical analysis of a frequency of conjunctions (and thus the sentences as well with generative semantics in the concluding section of the article allows the author to conclude that certain types of texts - in this particular case the texts are represented by the New Testament discourse - are characterized precisely by the causal-implicative orientation of the hypotaxis, because more than 1/3 of a total text of the four gospels uses precisely sentences with a causal meaning. The author concludes that this result confirms further that the causal- implicative syntactic structures considered in this article demand further, even deeper, research. [Projekat Ministarstva nauke Republike Srbije, br. 178021: Opis i standardizacija savremenog srpskog jezika

  3. Condutas usuais entre os reumatologistas brasileiros: levantamento nacional Routine clinical practices of Brazilian rheumatologists: national overview

    Directory of Open Access Journals (Sweden)

    Marta M. C. Medeiros

    2006-04-01

    ão-hormonais (AINHs (89,3%, relaxante muscular (72,9%, fisioterapia (33,3%. O repouso no leito foi orientado por 31,6% dos especialistas. Num caso de lombalgia crônica com raio X recente mostrando espondilolistese grau 1 e discoartrose, 39,6% dos reumatologistas não solicitavam nenhum exame adicional, enquanto 26,2% e 24,4% solicitavam tomografia computadorizada (TC e ressonância nuclear magnética (RNM, respectivamente. As condutas mais indicadas nesse caso foram: fisioterapia (75,1%, relaxante muscular (48,5%, RPG (45,6%, exercícios físicos (41%, AINH seletivo da Cox-2 (40,5%, amitriptilina (35,3%, analgésicos opióides (34,7%. Outros cenários de artrose de joelho e ombro doloroso foram apresentados. CONCLUSÕES: a baixa taxa de devolução dos questionários pode refletir uma prática ainda não-incorporada na nossa cultura. O perfil dos reumatologistas respondedores é muito semelhante entre as regiões. A maioria das condutas escolhidas está de acordo com as melhores evidências disponíveis, refletindo uma homogeneidade de abordagem terapêutica entre os reumatologistas. Embora este estudo traga importantes dados sobre a prática reumatológica, pode não ser representativo da população de reumatologistas brasileiros, tendo em vista o baixo percentual de respondedores.OBJECTIVE: Evaluate routine clinical practices of Brazilian rheumatologists. METHOD: Virtual clinical scenarios representing a range of rheumatological practical situations were sent by mail to 831 specialists certified by the Brazilian Society of Rheumatology (SBR with postage-paid envelopes for reply. RESULTS: Only 21.4% of the questionnaires were returned. The average age of responding rheumatologists was 42.7 years (SD=11.7, with an average time since graduation from medical school of 19.8 years (SD=10.1. In a clinical scenario describing early active rheumatoid arthritis most respondents (84.7% chose to initiate treatment with prednisone or prednisolone. The most chosen disease modifying

  4. Revisão sobre o uso de gabapentina para controle da dor pós-operatória Revisión sobre el uso de gabapentina para el control del dolor postoperatorio Review of the use of gabapentin in the control of postoperative pain

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    Jefferson Clivatti

    2009-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A gabapentina tem sido utilizada como adjuvante no tratamento da dor pós-operatória com componente neuropático. É responsável pela inibição da sensibilização central, diminuindo a dor pós-operatória. CONTEÚDO: Foram selecionados todos os estudos clínicos com distribuição aleatória que avaliaram o efeito da gabapentina na dor pós-operatória em humanos entre 2002 e 2007. Foram encontrados 26 artigos publicados. Em 17 estudos os pacientes receberam dose única pré-operatória que variou de 300 a 1.200 mg entre 30 min e duas horas antes dos procedimentos. Nos demais estudos a medicação foi iniciada entre uma e 24 horas antes dos procedimentos, foi continuada por dois a dez dias na dose de 1.200 a 1.800 mg.dia-1. Para medida de intensidade da dor foram utilizadas a Escala Analógica Visual ou Numérica. Em 75% dos que receberam somente dose pré os escores foram menores com uso de gabapentina e também em 55,6% dos que receberam dose pré e pós. O consumo de opióide foi menor em 82,4% dos que receberam dose pré e em 77,8% dos que receberam pré e pós. Em estudos que usaram pré, quatro não descreveram efeitos adversos; não houve diferença em 52,9%, mais náusea ou vômito em 11,8%, mais tontura em 5,9%, mais sedação em 5,9%, menos náusea ou vômito em um e menos retenção urinária em um. Em estudos que usaram pré e pós, quatro não descreveram efeitos adversos; não houve diferença em 22,2%, mais náusea ou vômito em 11,1%, mais tontura em 22,2% e mais sedação em 11,1%. CONCLUSÕES: A gabapentina usada tanto antes como antes e após a operação promove diminuição da intensidade da dor e da necessidade de complementação analgésica.JUSTIFICATIVA Y OBJETIVOS: La gabapentina ha sido utilizada como adyuvante en el tratamiento del dolor postoperatorio con componente neuropático. Es responsable de la inhibición de la sensibilización central, disminuyendo el dolor postoperatorio

  5. Analgesia pós-operatória com bloqueio bilateral do nervo pudendo com bupivacaína S75:R25 a 0,25%: estudo piloto em hemorroidectomia sob regime ambulatorial Analgesia pos-operatoria con bloqueo bilateral del nervio pudendo con bupivacaína S75:R25 a 0,25%: estudio piloto en hemorroidectomia bajo régimen ambulatorial Bilateral pudendal nerves block for postoperative analgesia with 0.25% S75:R25 bupivacaine: pilot study on outpatient hemorrhoidectomy

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    Luiz Eduardo Imbelloni

    2005-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A hemorroidectomia pode ser realizada sob várias técnicas anestésicas e em regime ambulatorial. A dor pós-operatória é intensa e pode atrasar o retorno para a residência. O objetivo deste estudo foi avaliar as vantagens e a realização do bloqueio bilateral dos nervos pudendos para analgesia pós-operatória em hemorroidectomias. MÉTODO: O bloqueio bilateral dos nervos pudendos com bupivacaína S75:R25 a 0,25% foi realizado com estimulador de nervos em 35 pacientes submetidos à hemorroidectomia sob raquianestesia. Foram avaliadas intensidade da dor, duração da analgesia, analgesia de demanda e eventuais complicações relacionadas à técnica. Os dados foram avaliados às 6, 12, 18, 24 e 30 horas após o término da intervenção cirúrgica. RESULTADOS: Em todos os pacientes, foi obtido sucesso com a estimulação de ambos os nervos pudendos. Em nenhum momento da avaliação ocorreu dor intensa. Até 12 horas após o bloqueio, todos os pacientes apresentaram anestesia na região perineal; com 18 horas, 17 pacientes e 24 horas; 10 pacientes A analgesia pós-operatória foi ótima em 18 pacientes; satisfatória, em cinco pacientes; e insatisfatória, em sete pacientes. A duração média da analgesia foi de 23,77 horas. Não ocorreram alterações da pressão arterial, da freqüência cardíaca, nem foram observadas náuseas ou vômitos. Todos os pacientes tiveram micção espontânea. Nenhuma complicação local ou sistêmica foi relacionada ao anestésico local. Vinte e sete pacientes classificaram de excelente a técnica de analgesia e apenas três pacientes do sexo masculino ficaram satisfeitos o que foi justificado pela anestesia no pênis. CONCLUSÕES: O bloqueio bilateral dos nervos pudendos, orientado por estimulador de nervos, proporciona a analgesia de excelente qualidade, com baixa necessidade de opióides, sem complicações local ou sistêmica e sem retenção urinária. Estudos controlados

  6. Analgesia peridural contínua: análise da eficácia, efeitos adversos e fatores de risco para ocorrência de complicações Analgesia peridural continua: análisis de la eficacia, efectos adversos y factores de riesgo para ocurrencia de complicaciones Continuous epidural analgesia: analysis of efficacy, side effects and risk factors

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    Leonardo Teixeira Domingues Duarte

    2004-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A analgesia promovida pela infusão peridural de anestésico local com analgésicos opióides é reconhecidamente de boa qualidade e com poucos efeitos adversos. O objetivo deste estudo foi determinar o número, formas e gravidade das complicações pós-operatórias relacionadas à analgesia peridural e à inserção do cateter peridural. MÉTODO: Foram avaliados, retrospectivamente, 469 pacientes submetidos à analgesia peridural pós-operatória entre 18/10/1999 e 18/10/2001. A analgesia peridural foi conduzida usando-se solução de bupivacaína a 0,1% com fentanil (1 a 5 µg.ml-1, iniciando-se a infusão de 3 ml.h-1. A velocidade de infusão era ajustada de acordo com a queixa álgica do paciente. Foram analisadas as seguintes variáveis: a duração da infusão peridural; a ocorrência de efeitos adversos e complicações, relacionando-os aos dados demográficos, tipo de cirurgia e posição do cateter peridural; e a qualidade da analgesia obtida com a técnica (escala analógico-visual de dor e índice de satisfação do paciente. RESULTADOS: Os cateteres peridurais permaneceram implantados uma média de 2,2 dias, variando de 6 horas a 10 dias, e o índice global de complicações relacionadas à técnica foi de 46,3%, sendo que a maioria foi de pequena magnitude, sem repercussão clínica. Destas, 13,9% estavam relacionadas diretamente ao cateter peridural (desconexão, exteriorização, dor lombar, inflamação e infecção local. Outras complicações mais comumente encontradas foram vômitos e retenção urinária. A analgesia pós-operatória foi efetiva com 97,2% dos pacientes referindo satisfação com a técnica. Pacientes sem dor ou com dor leve, no primeiro, segundo e terceiro dias de pós-operatório, constituíram, respectivamente, 80,1%, 92,8% e 93,3% da população estudada. CONCLUSÕES: A analgesia peridural contínua é efetiva e segura. As complicações ocorridas não foram consideradas graves

  7. Administração inadvertida de 4 mg de morfina por via subaracnóidea: relato de caso Administración inadvertida de 4 mg de morfina por vía subaracnoidea: relato de caso Accidental subarachnoid administration of 4 mg of morphine: case report

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    Bruno Salomé de Morais

    2008-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A administração de morfina por via subaracnóidea é técnica bem estabelecida para analgesia pós-operatória devido a sua eficácia, segurança e baixo custo. A administração inadvertida de 4 mg de morfina por via subaracnóidea complicada por fibrilação atrial ap��s administração de naloxona foi o objetivo desse relato. RELATO DO CASO: Paciente do sexo masculino, 45 anos, 75 kg, 1,72 m, estado físico ASA II, hipertenso, a ser submetido à reconstrução do ligamento cruzado anterior do joelho esquerdo. Após a realização da raquianestesia, foi constatada troca da ampola de morfina, com administração de 4 mg (0,4 mL da ampola de 10 mg por via subaracnóidea. A freqüência respiratória oscilou entre 12 e 16 incursões respiratórias por minuto e o paciente manteve-se estável hemodinamicamente sem queixas no intra-operatório. Após 30 minutos da admissão na SRPA, apresentou vômitos e sudorese, tratados com 0,4 mg de naloxona seguidos de infusão contínua de 0,2 mg.h-1 até o desaparecimento dos sintomas. A infusão contínua de naloxona foi mantida na Unidade de Terapia Intensiva (UTI, onde a pressão arterial, freqüência cardíaca, freqüência respiratória, saturação de oxigênio foram monitoradas, assim como a presença de náusea, prurido, vômito, sedação, dor e retenção urinária observadas. Após 2 horas de admissão na UTI, o paciente apresentou fibrilação atrial aguda sem instabilidade hemodinâmica. O ritmo sinusal foi restabelecido após 150 mg de amiodarona e interrupção da infusão de naloxona. Nas 18 horas seguintes apresentou estabilidade hemodinâmica e evoluiu sem outras intercorrências até a alta hospitalar. CONCLUSÕES: O presente relato alerta para o risco de troca de medicamentos durante o ato anestésico e ressalta a importância do encaminhamento dos pacientes em tratamento de sobredose de opióides à UTI em virtude de seus potenciais efeitos adversos

  8. Efeito preemptivo da morfina por via venosa na analgesia pós-operatória e na resposta ao trauma cirúrgico Efecto preemptivo de la morfina por vía venosa en la analgesia pós-operatoria y en la respuesta al trauma quirúrgico The effect of preemptive intravenous morphine on postoperative analgesia and surgical stress response

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    Levent Kiliçkan

    2001-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Embora os primeiros estudos sobre analgesia preemptiva tenham demonstrado que o bloqueio pré-operatório com anestésicos locais ou a medicação pré-anestésica com opióides sistêmicos eram mais eficazes no alívio da dor pós-operatória do que qualquer outro tratamento, o resultado de outros estudos comparando os efeitos do tratamento pré operatório ao mesmo tratamento iniciado após a cirurgia, produziram efeitos inconsistentes. As razões para essa falta de consistência não são claras. São poucos os estudos sobre a relação entre analgesia preemptiva e o consumo de analgésicos e a resposta ao trauma cirúrgico. O objetivo deste estudo foi avaliar o efeito preemptivo da morfina por via venosa preemptiva no consumo pós-operatório de analgésicos e na resposta ao trauma cirúrgico. MÉTODO: Participaram deste estudo 60 pacientes, estado físico ASA I ou II, com idades entre 20 e 60 anos, escalados para histerectomia abdominal total e salpingo-ooferectomia bilateral, que foram aleatoriamente distribuídos em três grupos de 20 pacientes. Grupo I (n=20 - 0,15 mg.kg-1 de morfina após a indução anestésica e soro fisiológico durante o fechamento do peritônio. Grupo II (n=20 - soro fisiológico após a indução e 0,15 mg.kg-1 de morfina durante o fechamento do peritônio. Grupo III (n=20 soro fisiológico durante a indução e o fechamento do peritônio. Foram medidos os níveis sangüíneos de cortisol e de glicose e feita a contagem de leucócitos nos períodos pré e pós-operatórios. RESULTADOS: O consumo total de morfina pós-operatória foi significativamente mais baixo no grupo I comparado ao grupo III (p JUSTIFICATIVA Y OBJETIVOS: No obstante los primeros estudios sobre analgesia preemptiva hayan demostrado que el bloqueo pré-operatorio con anestésicos locales o la medicación pré-anestésica con opioides sistemicos eran mas eficaces en el alivio del dolor pós-operatorio de que cualquier

  9. Análise clínica e terapêutica dos pacientes oncológicos atendidos no programa de dor e cuidados paliativos do Hospital Universitário Clementino Fraga Filho no ano de 2003 Análisis clínico y terapéutico de los pacientes oncológicos atendidos en el programa de dolor y cuidados paliativos del Hospital Universitario Clementino Fraga Filho en el año 2003 Clinical and therapeutic analysis of oncology patients treated at the pain and palliative care program of the Hospital Universitário Clementino Fraga Filho in 2003

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    Giselane Lacerda Figueredo Salamonde

    2006-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os cuidados paliativos têm como meta principal o controle da dor e de outros sintomas nos pacientes com doenças crônicas, sem possibilidade de cura, sobretudo no câncer avançado. A dor intensa acomete 75% dos pacientes com câncer avançado, interferindo na qualidade de vida e segundo a OMS é considerada uma emergência médica mundial. Este estudo avaliou o perfil dos pacientes oncológicos do Programa de Tratamento da Dor Crônica e Cuidados Paliativos do HUCFF/FM/UFRJ, ressaltando a atuação do anestesiologista, as medicações utilizadas, a humanização do tratamento e a melhor qualidade de vida do paciente. MÉTODO: Retrospectivamente, foram analisados os prontuários dos pacientes oncológicos no ano de 2003. Destacaram-se os parâmetros: idade, raça, sexo, doenças preexistentes, órgão de origem do câncer, tipo de dor e outros sintomas, medicações utilizadas, rotinas hospitalares e o término do tratamento. RESULTADOS: Os tipos de dor encontrados foram nociceptiva, neuropática e incidental, avaliadas utilizando-se a escala unidimensional de faces. Verificou-se a analgesia controlada pelo paciente (PCA com metadona, via oral, em ambiente domiciliar na 1ª semana. Após esse período, o paciente retornava ao ambulatório para o cálculo da dose regular da metadona. Outros opióides utilizados foram codeína, tramadol, morfina e oxicodona. Além da dor, os pacientes apresentaram: constipação, náuseas, vômitos, delirium, alteração do sono e dispnéia. Os neurolépticos, corticóides e laxantes foram usados como fármacos adjuvantes. CONCLUSÕES: A analgesia controlada pelo paciente utilizando a metadona mostrou-se segura e eficaz pela não-ocorrência de efeitos colaterais significativos. O conhecimento clínico e farmacológico do anestesiologista na equipe multiprofissional proporcionou melhor atendimento para o alívio dos sintomas dos pacientes e humanização no período final de vida

  10. Experiência clínica com o uso de sedativos em terapia intensiva: estudo retrospectivo Experiencia clínica con el uso de sedativos en la terapia intensiva: estudio retrospectivo Clinical experience with sedatives in the intensive care unit: a retrospective study

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    Geraldo Rolim Rodrigues Júnior

    2002-11-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Dentre as indicações mais freqüentes de sedação em pacientes internados em Unidades de Terapia Intensiva (UTI estão a instituição e a manutenção de ventilação artificial, a ansiedade e procedimentos desconfortáveis ou dolorosos. O objetivo deste estudo retrospectivo foi verificar as indicações e as técnicas mais comuns de sedação em pacientes graves internados na Unidade de Terapia Intensiva Cirúrgica da Escola Paulista de Medicina (EPM/UNIFESP durante um período de 11 meses. MÉTODO: Após terem sido excluídos os pacientes que permaneceram na UTI menos de 24 horas ou estavam sem exames indispensáveis para o cálculo do índice de gravidade (APACHE II, a amostra ficou reduzida a 307 pacientes. Foram analisadas as técnicas mais utilizadas, as indicações de sedação e a associação de bloqueadores neuromusculares. RESULTADOS: A sedação foi administrada em 37,4% dos pacientes. Entre as indicações de sedação estão os distúrbios de natureza psiquiátrica, como delírio, agitação, medo e ansiedade. Estas corresponderam a 25,77% de todas as indicações. A maioria dos pacientes ventilados artificialmente também necessita de sedativos. Instalação e manutenção de ventilação mecânica corresponderam à maioria das indicações, em torno de 57,73% dentre os pacientes sedados. Procedimentos como intubação traqueal e broncoscopia tiveram 11,34% das indicações e controle do metabolismo (coma barbitúrico e tétano, 5,15%. As técnicas mais comumente utilizadas incluíram opióides isolados ou associados a benzodiazepínicos. Neste estudo, o fentanil foi utilizado em 58% das técnicas, isoladamente, e em 21,64% associado ao midazolam. Haloperidol, diazepam, propofol e tiopental somaram 19,5%. Bloqueadores neuromusculares foram utilizados em 22,7% dos casos em pacientes ventilados artificialmente. CONCLUSÕES: A sedação é recurso terapêutico freqüente em Terapia Intensiva, comumente

  11. Anestesia para o recém-nascido submetido a cirurgia cardíaca com circulação extracorpórea Anestesia para el recién nacido sometido a cirugía cardiaca con circulación extracorpórea Anesthesia for the newborn submitted to cardiac surgery with cardiopulmonary bypass

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    Sérgio Bernardo Tenório

    2005-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As doenças congênitas do coração atingem 0,8% dos recém-nascidos (RN vivos, sendo que muitos necessitam de correção cirúrgica ainda no período neonatal. A cirurgia cardíaca com circulação extracorpórea (CEC, nesta faixa etária, associa-se a maior incidência de complicações, devido à imaturidade funcional da criança, à falta de equipamentos de CEC que sejam totalmente compatíveis com as dimensões do RN e às dificuldades técnicas para correção da lesão cardíaca. Este artigo tem o propósito de apresentar os aspectos relacionados à técnica anestésica, a CEC e seus efeitos em RN. CONTEÚDO: Elevadas doses de fentanil ou sufentanil provêm adequada anestesia sem interferir na estabilidade cardiocirculatória. A depressão respiratória residual dos opióides não é problema neste grupo de pacientes porque a maioria necessita assistência respiratória no pós-operatório imediato. A entrada em CEC pode ser acompanhada de hipotensão arterial por manipulação do coração e/ou sangramento. O posicionamento inadequado das cânulas venosas e aórtica pode causar sérias complicações, como insuficiente fluxo encefálico ou dificuldade na drenagem venosa. São comuns a utilização de hipotermia profunda e a parada circulatória total durante a CEC. A hipotermia modifica a viscosidade do sangue que é tratada com hemodiluição e traz implicações para a correção do pH (alfa-stat versus pH stat. No desmame da CEC é freqüente ocorrer baixo débito cardíaco e ajustes em um ou em todos os seus componentes ( pré-carga, contratilidade, pós-carga e freqüência cardíaca podem ser necessários. Além das drogas clássicas, como a adrenalina e a dopamina, pode ser necessário o emprego de outras substâncias como a aprotinina, o óxido nítrico ou os inibidores da fosfodiesterase. CONCLUSÕES: O anestesiologista tem papel preponderante no ajuste da homeostasia durante o período peri

  12. Estudo prospectivo das repercussões de baixas doses de remifentanil na função sinoatrial e na condução e refratariedade cardíaca Estudio prospectivo de las repercusiones de bajas dosis de remifentanil en la función sinoatrial en la conducción y refractariedad cardiaca Prospective study on the repercussions of low doses of remifentanil on sinoatrial function and in cardiac conduction and refractory period

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    Simone Soares Leite

    2007-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O remifentanil é um opióide com início e término de ação rápidos, cujo uso em procedimentos de curta duração vem se propagando nos últimos anos. Entre os efeitos colaterais descritos, há relatos de bradicardia e assistolia. O objetivo deste estudo foi avaliar os efeitos desse fármaco na condução e refratariedade cardíaca, em humanos. MÉTODO: Estudo prospectivo de 16 pacientes, entre 18 e 65 anos, de ambos os sexos, ASA I a III, submetidos a estudo eletrofisiológico intracardíaco eletivo. Foram excluídos os pacientes com doença do nódulo sinoatrial e os portadores de bloqueios cardíacos graves. No laboratório de eletrofisiologia, os pacientes foram inicialmente sedados com midazolam (0,03 mg.kg-1, após 5 minutos (M0 avaliou-se o grau de sedação de intensidade de dor, pressões arteriais sistólica e diastólica, freqüências cardíaca e respiratória e saturação de oxigênio. O eletrofisiologista avaliou as variáveis de condução cardíaca (duração do QRS, intervalos AA, AH, HV e PA, o tempo de recuperação do nódulo sinoatrial e as variáveis de refratariedade cardíaca (período refratário do átrio direito, período refratário do ventrículo direito e período refratário do nódulo atrioventricular. Após as medidas iniciais o remifentanil foi introduzido (bolus de 0,5 µg.kg-1 + infusão de 0,05 µg.kg-1.min-1 e após 20 minutos as mesmas variáveis foram reavaliadas (M1. RESULTADOS: Observou-se diminuição das pressões sistólica e diastólica (p = 0,0001 entre M0 e M1, sem diferença estatística significativa da freqüência respiratória ou da saturação de oxigênio. Houve aumento do intervalo átrio-His (p = 0,006 e do tempo de recuperação do nódulo sinoatrial (p = 0,0004, do período refratário do átrio direito (p = 0,001 e do período refratário do nódulo atrioventricular (p = 0,0001, porém não houve diminuição da freqüência cardíaca basal entre M0 e M1

  13. Application of Relevance Maps in Multidimensional Classification of Coal Types / Zastosowanie Map Odniesienia W Wielowymiarowej Klasyfikacji Typów Węgla

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    Niedoba, Tomasz

    2015-03-01

    żdej cechy (współrzędnej) zostaje przyporządkowany punkt odniesienia reprezentujący tą cechę. Czyli przy danych 7-wymiarowych umieszczamy na płaszczyźnie 7 takich punktów odniesienia reprezentujących poszczególne współrzędne. Rozkład punktów reprezentujących przedstawiane wielowymiarowe dane odzwierciedla relacje pomiędzy tymi danymi a cechami. Im bardziej i-ta cecha występuje w danym obiekcie (czyli i-ta współrzędna ma większą wartość), tym bliżej powinien leżeć punkt reprezentujący dany obiekt względem punktu odniesienia reprezentującego i-tą cechę (współrzędną). W ten sposób każdy punkt odniesienia reprezentujący daną cechę, dzieli płaszczyznę na obszary bardziej oraz mniej zależne od cechy nr i (mniej oraz bardziej odległe od punktu odniesienia reprezentującego i-tą cechę). Dokładny opis algorytmu przedstawiono w podrozdziale 3 artykułu. Za pomocą omawianej metody dokonano wizualizacji danych dotyczących przedstawionych typów węgla. Uzyskane rezultaty przedstawiono na rysunkach 1-9. Widoki te pokazują sposób, w jaki 7-wymiarowe dane zostają przekształcone przy pomocy mapy odniesienia do dwóch wymiarów. Algorytm wizualizacji przy użyciu mapy odniesienia działa tak by pomimo znacznej redukcji liczby wymiarów, w jak największym stopniu odległości pomiędzy punktem reprezentującym konkretny wektor danych a punktami odniesienia zależały od współrzędnych tego wektora danych. W ten sposób na ekranie 2-wymiarowym, możemy zobaczyć istotne cechy danych 7-wymiarowych. Na rysunkach 1-4 widać, w jaki sposób wzrasta grupowanie punktów reprezentujących trzy różne klasy węgla (31, 34.2 oraz 35) wraz ze wzrostem parametru ITER. Widać, że punkty będące obrazami danych reprezentujących te same klasy węgla zaczynają zajmować osobne podobszary oraz zaczynają się grupować. Jednak w niektórych częściach przestrzeni obrazy punktów reprezentujących różne klasy węgla zachodzą na siebie. Przez

  14. Importância da hemoglobina glicada no controle do diabetes mellitus e na avaliação de risco das complicações crônicas Glycohemoglobin importance in the diabetes mellitus control and in the risk evaluation of chronic complications

    Directory of Open Access Journals (Sweden)

    Nairo Massakazu Sumita

    2008-06-01

    atingida, representando efetivo controle, em ambas as condições é abaixo de 7%, tanto no adulto como no adulto jovem. Para as crianças durante a fase pré-puberal, o nível aceitável de A1C é de até 8% e, na fase puberal, até 8,5%. Nos pacientes idosos, a A1C de até 8% é considerada apropriada, uma vez que a tentativa de um controle muito rígido da glicemia nesta faixa etária, assim como nas fases pré-puberal e puberal, pode induzir a efeitos colaterais indesejados, como, por exemplo, hipoglicemia. Para a paciente gestante não está indicado o acompanhamento do controle glicêmico pela dosagem de A1C, sendo mais eficiente o controle dos níveis das glicemias de jejum e duas horas após as refeições e a dosagem de frutosamina, que corresponde ao conjunto das proteínas plasmáticas glicosadas. O grande diferencial da A1C em relação à glicemia de jejum é que os níveis daquela variam mais lentamente, dependendo da meia-vida das hemácias, portanto não retornam ao normal imediatamente depois da normalização da glicose no sangue. O tempo para que a A1C atinja os níveis adequados após um período de hiperglicemia é de aproximadamente dez semanas. Assim, a repetição do exame de A1C para avaliar a eficácia de um tratamento deve ser realizada somente dois a três meses depois do início ou da modificação do esquema terapêutico. Doenças que alteram a sobrevida das hemácias, como anemia hemolítica e hemorragia, por reduzirem sua vida média, podem resultar em valores falsamente baixos de Hb A1C, enquanto as anemias por carência de ferro, de vitamina B12 ou de folato, que aumentam a vida média das hemácias, resultam em valores falsamente elevados. Na dependência da metodologia utilizada, outras condições clínicas podem interferir no resultado de A1C, como hipertrigliceridemia, hiperbilirrubinemia, uremia, alcoolismo crônico, uso prolongado de opiáceos ou de salicilatos. O posicionamento oficial brasileiro recomenda a utilização de m

  15. Prikazi

    Directory of Open Access Journals (Sweden)

    Drahomira Gavranović

    2012-02-01

    nazivom U potrazi za našom pisanom baštinom: izazovi, perspektive, pitanja. Autor prikazuje stanje rukopisnih zbirki u zemljama istočne i jugoistočne Europe (Armenija, Bugarska, Rumunjska, Albanija, Makedonija i Hrvatska. U radu se govori o postupcima zaštite, digitalizacije i katalogizacije te mogućnostima provedbi znanstvenih istraživanja na dosad potpuno nepoznatim zbirkama. Autor daje primjere istraživanja koja bi se mogla provoditi na tim vrijednim rukopisnim zbirkama, od istraživanja načina čitanja samih rukopisa do istraživanja fragmenata, vodenih žigova, palimpsesta i sl. Rad je ovo koji otvara mnoga zanimljiva istraživačka pitanja. Autorica J. Lakuš izradila je rad pod naslovom Stare knjige, bibliografija i njezine istraživačke mogućnosti. Autorica nas u svome radu upoznaje s istraživanjima u području historijske bibliografije, unutar kojeg se knjiga promatra u širem kontekstu te se, osim uobičajenih bibliografskih podataka, bilježe npr. i podaci o posvetama, knjižarskim oglasima, cijeni knjige, vlasništvu i drugim zanimljivostima na knjigama i u njima. S obzirom da se knjigom bave različiti korisnici koji imaju različite potrebe (knjižničari, bibliografi, povjesničari..., autorica drži da bi bibliografije trebale biti prilagođene njihovim potrebama. Treći rad u ovoj cjelini posvećen je knjižarskim katalozima. Autorica E. Netchine u radu pod naslovom Knjižarski katalozi u zbirci Nacionalne knjižnice Francuske u Parizu: znanstveni opis zbirke efemerne građe donosi izvrstan primjer dobre prakse. Vrlo je malo istraživanja posvećeno proučavanju knjižarskih kataloga i stoga je ovaj rad iznimno značajan za sve koji se žele baviti tom temom. Nacionalna knjižnica Francuske objavila je znanstveni opis svoje zbirke knjižarskih kataloga tiskanih u Europi u razdoblju od 1473. do 1810. godine. Iznimno je to djelo koje čini polazište mnogim budućim istraživačima ove efemerne građe. Jedna od tema unutar druge cjeline ovoga

  16. Fabrication and Testing of Prototype APM-Clad UO{sub 2} Fuel Elements; Fabrication et essai de prototypes de cartouches de combustible en bioxyde d'uranium gaine d'aluminium (APM); Izgotovlenie i ispytanie prototipa toplivnykh ehlementov na osnove UO{sub 2} s obolochkoj iz alyuminiya metodom poroshkovoj metallurgii; Elaboracion y ensayo de elementos combustibles prototipo de UO{sub 2} con revestimiento de aluminio sinterizado

    Energy Technology Data Exchange (ETDEWEB)

    Ballif, III, J. L.; Friske, W. H.; Gordon, R. B. [Atomics International, Canoga Park, California (United States)

    1963-11-15

    compatibilidad entre el material PMA y el UO{sub 2} . De estos trabajos, se deduce que, en las condiciones actuales, el metodo de union eutectica es el mas adecuado para cerrar los extremos de los revestimientos; con la compresion vibratoria, se obtuvieron densidades del combustible del orden del 80 al 88% del valor teorico, y no se produjo reaccion alguna entre el material PMA y el UO{sub 2} en el intervalo de temperaturas de funcionamiento del POPR (temperatura maxima de 850{sup o}F en la superficie de separacion entre el combustible y el revestimiento). Como resultado de estos trabajos, se han elaborado cinco elementos combustibles prototipo de UO{sub 2}, revestido con material PMA, para ensayarlos en el reactor experimental de moderador organico (OMRE). Cada elemento esta compuesto por 24 o 25 barras de combustible revestidas de material PMA, dispuestas en grupos de 5 x 5 en una caja para combustible de acero niquelado o de material PMA. Con el proposito de aumentar la superficie, el revestimiento extruido de material PMA lleva ocho aletas dispuestas en espiral con un paso de 45 o 90{sup o}/pie , cuya funcion es mejorar la transmision de calor. Los cierres de los extremos de las barras de combustible se han realizado por union eutectica de tapones de aluminio plateado a los tubos de material PMA. Los elementos combustibles estan dotados de instrumentos para: 1 . Medir las temperaturas de la superficie del revestimiento y del refrigerante; 2. Detectar defectos de las barras de combustible; 3 . Modificar la velocidad del refrigerante (como medio para obtener una temperatura maxima de la superficie del revestimiento de 850{sup o}F); 4. Medir la velocidad del refrigerante; 5. Medir la acumulacion de gases de fision. Dichos elementos se instalaron en e l reactor OMRE con el proposito de obtener grados de combustion de 25 000 a 30 000 MWd/t de uranio. El 1- de abril de 1963 habian alcanzado grados de combustion acumulativos que oscilaban entre 7700 y 12 000 MWd/t de uranio. Dos de