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Sample records for opis dwoch przypadkow

  1. The structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo NAD(+) content in OPI-induced teratogenesis in chickens.

    Science.gov (United States)

    Seifert, Josef

    2016-05-01

    The objective of this study was to determine the structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo nicotinamide adenine dinucleotide (NAD(+)) content in OPI-induced teratogenesis and compare them with those needed for OPI inhibition of yolk sac membrane kynurenine formamidase (KFase), the proposed primary target for OPI teratogens in chicken embryos. The comparative molecular field analysis (COMFA) of three-dimensional quantitative structure-activity relationship (3D QSAR) revealed the electrostatic and steric fields as good predictors of OPI structural requirements to reduce NAD(+) content in chicken embryos. The dominant electrostatic interactions were localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and at the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-6 of the pyrimidinyls and/or N-substituents of crotonamides was the steric structural component that contributed to superiority of those OPI for reducing embryonic NAD(+) levels. Both electrostatic and steric requirements are similar to those defined in our previous study for OPI inhibition of chicken embryo yolk sac membrane KFase. The findings of this study provide another piece of evidence for the cause-and-effect relationship between yolk sac membrane KFase inhibition and reduced embryo NAD(+) content in NAD-associated OPI-induced teratogenesis in chickens.

  2. Structural requirements of organophosphorus insecticides (OPI) to inhibit chicken yolk sac membrane kynurenine formamidase related to OPI teratogenesis.

    Science.gov (United States)

    Seifert, Josef

    2013-03-01

    This paper provides new information related to the mechanism of OPI (organophosphorus insecticides) teratogenesis. The COMFA (comparative molecular field analysis) and COMSIA (comparative molecular similarity indices analysis) suggest that the electrostatic and steric fields are the best predictors of OPI structural requirements to inhibit in ovo chicken embryo yolk sac membrane kynurenine formamidase, the proposed target for OPI teratogens. The dominant electrostatic interactions are localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-2 and carbon-6 of the pyrimidinyls and/or N-substituents and carbon-3 substituents of crotonamides are the steric structural components that contribute to superiority of those OPI as in ovo inhibitors of kynurenine formamidase.

  3. Validation and verification of the OPI 2.0 System

    Directory of Open Access Journals (Sweden)

    Abelson R

    2012-04-01

    Full Text Available Richard Abelson1,2, Keith J Lane3, John Rodriguez3, Patrick Johnston3, Endri Angjeli3, George Ousler3, Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, 2Statistics and Data Corporation, Tempe, AZ, 3Ora, Inc, Andover, MA, USAPurpose: The Ocular Protection Index (OPI 2.0 System was developed to evaluate ocular surface protection under a natural blink pattern and normal visual conditions. The OPI 2.0 System implements fully automated software algorithms which provide a real-time measurement of corneal exposure (breakup area for each interblink interval during a 1-minute video. Utilizing this method, the mean breakup area (MBA and OPI 2.0 (MBA/interblink interval were calculated and analyzed. The purpose of this study was to verify and validate the OPI 2.0 System for its ability to distinguish between dry eye and normal subjects, and to accurately identify breakup area.Methods: In order to verify and validate the OPI 2.0 System, a series of artificial images and a series of still image frames captured during an actual clinical session using fluorescein staining videography were analyzed. Finally, a clinical validation process was completed to determine the effectiveness and clinical relevance of the OPI 2.0 System to differentiate between dry eye and normal subjects.Results: Software analysis verification conducted in a set of artificially constructed images and in actual videos both saw minimal error rates. MBA and OPI 2.0 calculations were able to distinguish between the qualifying eyes of dry eye and normal subjects in a statistically significant fashion (P < 0.001 for both outcomes. As expected, dry eye subjects had a higher MBA and OPI 2.0 than normal subjects (0.232, dry eye; 0.040, normal and 0.039, dry eye; 0.006, normal, respectively. Results for the worst eyes and all qualifying analyses based on staining, forced-stare tear film breakup time, and MBA were

  4. Yet1p-Yet3p interacts with Scs2p-Opi1p to regulate ER localization of the Opi1p repressor.

    Science.gov (United States)

    Wilson, Joshua D; Thompson, Sarah L; Barlowe, Charles

    2011-05-01

    Lipid sensing mechanisms at the endoplasmic reticulum (ER) coordinate an array of biosynthetic pathways. A major phospholipid regulatory circuit in yeast is controlled by Scs2p, an ER membrane protein that binds the transcriptional repressor protein Opi1p. Cells grown in the absence of inositol sequester Scs2p-Opi1p at the ER and derepress target genes including INO1. We recently reported that Yet1p and Yet3p, the yeast homologues of BAP29 and BAP31, are required for normal growth in the absence of inositol. Here we show that the Yet1p-Yet3p complex acts in derepression of INO1 through physical association with Scs2p-Opi1p. Yet complex binding to Scs2p-Opi1p was enhanced by inositol starvation, although the interaction between Scs2p and Opi1p was not influenced by YET1 or YET3 deletion. Interestingly, live-cell imaging analysis indicated that Opi1p does not efficiently relocalize to the ER during inositol starvation in yet3Δ cells. Together our data demonstrate that a physical association between the Yet complex and Scs2p-Opi1p is required for proper localization of the Opi1p repressor to ER membranes and subsequent INO1 derepression.

  5. Classification of SN 2016gmg (=PTSS-16opy), as a Type Ia Supernova

    Science.gov (United States)

    Zhang, Jujia; Xin, Yuxin; Chang, Liang; Wang, Jianguo; Wang, Xiaofeng; Li, Wenxiong; Yang, Zesheng; Li, Bin; Xu, Zhijian; Zhao, Haibin; Wang, Lifan

    2016-09-01

    We obtained an optical spectrum (range 340-900 nm) of SN 2016gmg (=PTSS-16opy), discovered by the PMO-Tsinghua Supernova Survey (PTSS: http://119.78.210.3/ptss2/), on UT Sep. 29.55 2016 with the 2.4 m telescope (LJT + YFOSC) at LiJiang Observatory of Yunnan Observatories (YNAO).

  6. Special Operations Forces Language and Culture Needs Assessment: Oral Proficiency Interview (OPI)

    Science.gov (United States)

    2010-11-02

    understand the grammer rules of a language in order to support continued, more advanced, training.” SOF Language and Culture Needs Assessment Project...the OPI.  “If this is how they are going to test then this is how they need to teach the info”  “I don not have time to do language training as it

  7. Hindi Heritage Language Learners' Performance during OPIs: Characteristics and Pedagogical Implications

    Science.gov (United States)

    Ilieva, Gabriela Nik.

    2012-01-01

    The present paper examines the oral performance of Hindi language learners during practice Oral Proficiency Interviews (OPI) conducted during workshops hosted by New York University and sponsored by STARTALK. The most salient characteristics of the heritage language learners' output are compared with the output of foreign language learners who are…

  8. Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos.

    Science.gov (United States)

    Seifert, Josef

    2014-11-01

    The objective of this study was to identify proteins in mouse livers and chicken embryo yolk sac membranes whose quantities were altered by an organophosphorous insecticide (OPI) treatment and which might be linked, based on their functionality, to the recognized noncholinergic effects of OPI. Mice and fertile chicken eggs were treated with an OPI representative diazinon. The quantitative changes in mouse liver and chicken embryo yolk sac membrane soluble proteins caused by diazinon were determined by two-dimensional electrophoresis. Proteins whose quantity was affected by diazinon were identified by the mass spectrometry. In mouse livers, the altered levels of several enzymes of glucose metabolism were considered with regards to amelioration of hyperglycemia due to diazinon; the reduced levels of 3-hydroxyanthranilate 3,4-dioxygenase to the changes in the l-tryptophan to NAD metabolism caused by pyrimidinyl and crotonamide OPI; the reduced levels of catalase, peroxiredoxin and superoxide dismutase to OPI-increased lipid and/or kynurenine oxidation, the latter effect resulting also in increased urinary excretion of xanthurenic and kynurenic acids; and an increase in glutathione S-methyltransferase to OPI detoxification. In chicken embryo yolk sac membranes, the reduced availability of procollagen-proline dioxygenase may be the factor in micromelia caused by OPI in chicken embryos.

  9. Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.

    Science.gov (United States)

    Blake, E; Allen, J; Thorn, C; Shore, A; Curnow, A

    2013-05-01

    Methyl aminolevulinate photodynamic therapy (MAL-PDT) (a topical treatment used for a number of precancerous skin conditions) utilizes the combined interaction of a photosensitizer (protoporphyrin IX (PpIX)), light of the appropriate wavelength, and molecular oxygen to produce singlet oxygen and other reactive oxygen species which induce cell death. During treatment, localized oxygen depletion occurs and is thought to contribute to decreased efficacy. The aim of this study was to investigate whether an oxygen pressure injection (OPI) device had an effect on localized oxygen saturation levels and/or PpIX fluorescence of skin lesions during MAL-PDT. This study employed an OPI device to apply oxygen under pressure to the skin lesions of patients undergoing standard MAL-PDT. Optical reflectance spectrometry and fluorescence imaging were used to noninvasively monitor the localized oxygen saturation and PpIX fluorescence of the treatment area, respectively. No significant changes in oxygen saturation were observed when these data were combined for the group with OPI and compared to the group that received standard MAL-PDT without OPI. Additionally, no significant difference in PpIX photobleaching or clinical outcome at 3 months between the groups of patients was observed, although the group that received standard MAL-PDT demonstrated a significant increase (pMAL-PDT. Further investigation is therefore required to find a more effective method of MAL-PDT enhancement.

  10. Determination of traces of several pesticides in sunflower oil using organic phase immuno electrodes (OPIEs).

    Science.gov (United States)

    Martini, Elisabetta; Tomassetti, Mauro; Campanella, Luigi

    2015-01-01

    Testing for traces of different pesticides (triazinic, organophosphates and chlorurates), present in hydrophobic matrices such as sunflower oil was checked using new immunosensors working in organic solvent mixtures (OPIEs). The competitive process took place in an n-hexane-chloroform 75% (V/V) mixture, while the subsequent final enzymatic measurement was performed in decane using tert-butylhydroperoxide as substrate of the enzymatic reaction. A Clark electrode was used as transducer and peroxidase enzyme as marker. A linear response of between about 10 nM and 4 μM was usually obtained in the presence of sunflower oil. Immunosensors show satisfactory selectivity and precision and recovery tests carried out on commercial sunflower oil samples gave excellent results. Lastly, theoretical confirmation of the possibility that immunosensors can act positively in organic solvent mixtures was discussed on the basis of Hill׳s coefficient values.

  11. „Alfurkan tatarski” Piotra Czyżewskiego – opis zabytku (grafia z elementami fonetyki

    Directory of Open Access Journals (Sweden)

    Anetta Luto-Kamińska

    2015-12-01

    Full Text Available Alfurkan tatarski by Piotr Czyżewski – description of the old print (graphy with some phonetic aspects  This article discusses Alfurkan tatarski [Tartar Al Furqan] published by Piotr Czyżewski in 1617, which probably is the second expanded edition of the work. Based upon analysis of two copies of this early printing work, it presents some graphic features of the book. Phonetic and dialectal phenomena, which allow us to draw conclusions about the nature of the author’s language and its regional features, remain in close association with some of the print’s graphic elements.   Alfurkan tatarski Piotra Czyżewskiego – opis zabytku (grafia z elementami fonetyki W artykule opisuje się Alfurkan tatarski Piotra Czyżewskiego z 1617 roku, który jest najprawdopodobniej drugim, poszerzonym wydaniem utworu. Na podstawie analizy dwóch egzemplarzy zabytku przedstawiono cechy grafii druku. W ścisłym związku z niektórymi elementami grafii pozostają zagadnienia fonetyczne oraz dialektalne, które umożliwiają formułowanie wniosków na temat języka autora wraz z jego cechami regionalnymi.

  12. ¿Es necesario disponer de tratamientos con buprenorfina/naloxona para los presos dependientes de opiáceos?

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    A. Marco

    Full Text Available La utilización de programas de tratamiento con agonistas opiáceos (TAO, junto con un abordaje psicosocial, es la forma más efectiva de prevenir recaídas en los pacientes con dependencia a opiáceos. Estos programas disminuyen la morbimortalidad así como las conductas de riesgo de transmisión del VIH y de otras infecciones, mejoran la calidad de vida y la retención en tratamiento, y tienen un impacto positivo sobre los comportamientos asociales, por lo que son muy útiles en presos con antecedente de consumo de opiáceos. Los TAO basados en el uso de buprenorfina/naloxona (B/N, igual que los basados en metadona (MT, están actualmente disponibles en España. El tratamiento diversificado ofrece una alternativa de tratamiento para la dependencia de opioides más individualizada y adaptada a las características de los pacientes. En cuanto a eficacia ambos fármacos son muy similares, pero B/N es más segura, con menor perfil de interacciones con posibilidad de dispensación en farmacias una vez que el paciente sea puesto en libertad, lo que puede ayudar a la reintegración social. Económicamente, el tratamiento con B/N es más costoso que el de MT. Se aconseja disponer de las diferentes modalidades de TAO y que estas se prescriban según las características y necesidades de cada caso, sin que la reclusión menoscabe el derecho al tratamiento farmacológico, que debe ser similar al efectuado extrapenitenciariamente.

  13. Factores asociados a presentar parada respiratoria en las sobredosis por opiáceos atendidas en un escenario abierto de consumo de drogas en Barcelona

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    Manel Anoro

    2004-01-01

    Full Text Available Fundamento: Determinar los factores que se asocian a parada respiratoria en las sobredosis por opiáceos (coma, miosis pupilar, depresión respiratoria y respuesta a naloxona atendidas en el barrio de Can Tunis de Barcelona. Métodos: Se realizó un estudio observacional transversal, donde se incluyeron todas las sobredosis por opiáceos atendidas entre marzo del 2001 y junio del 2002. Se registraron las características previas del paciente, las del consumo de opiáceos que produjo la sobredosis, el consumo concomitante de otras substancias y la clínica, mediante una hoja de recogida de datos cumplimentada después de atender la sobredosis. En el análisis se realizó una regresión logística. Resultados: De las 222 sobredosis atendidas un 60,8% presentaron parada respiratoria. Se asoció a ella no haber consumido heroína en los últimas 2 semanas (OR: 1,893; p=0,04 y no haber consumido previamente benzodiazepinas (OR: 0,462; p=0,017. El consumo de alcohol, cocaína o metadona no predispondría a la aparición de parada respiratoria. Conclusiones: Se identifica como factor de riesgo principal para sufrir una parada respiratoria en una sobredosis por opiáceos una abstinencia previa superior a quince días. Por otra parte, el consumo de benzodiazepinas se asocia con la ausencia de parada respiratoria en la sobredosis. Sería interesante analizar otros factores, que podrían confundir nuestros resultados y que no han sido incluidos en el estudio, asociados tanto al consumo de benzodiazepinas como al hecho de no presentar parada respiratoria en una sobredosis.

  14. Alívio da dor crônica não neoplásica com opiáceos Alivio del dolor cronico no neoplásico con opiáceos Non oncologic chronic pain relief with opioids

    Directory of Open Access Journals (Sweden)

    Cibele Andrucioli de Mattos Pimenta

    1999-10-01

    Full Text Available O uso de opiáceos para o controle da dor crônica não relacionada ao câncer é controverso. Avaliar o alívio da dor e as mudanças nas atividades de vida diária advindas da infusão intratecal de opiáceos em 11 doentes, com dor crônica não neoplásica, foram os objetivos deste estudo. Todos os doentes haviam previamente sido submetidos a diversas modalidades terapêuticas sem alívio significativo. Os doentes foram solicitados a avaliar as características da dor e as atividades de vida diária comparando-as antes e após o tratamento com opiáceo intratecal por meio de sistemas implantados. Observou-se alívio da dor. No entanto, melhora da funcionalidade não foi observada com a mesma magnitude.El uso de opiáceo para el control del dolor crónico no relacionado al cáncer es controvertido. Evaluar el alivio del dolor y los cambios en las actividades de la vida diaria debidas a la infusión intratecal de opiáceos, en 11 pacientes con dolor crónico no neoplásico fue el objetivo de este estudio. Todos los pacientes habían previamente sido sometidos a las diversas modalidades terapéuticas sin alivio significativo del dolor. Los pacientes fueron entrevistados y se les solicitó evaluar el dolor y las actividades de la vida diaria, comparando antes y después del tratamiento con opiáceo intratecal. La infusión de opiáceo intratecal resulto en alivio del dolor. Sim embargo, la mejoría de la funcionalidad no fue observada con la misma magnitud.Opioids for non cancer pain control are controversial. The evaluation of the pain relief, changes in quality of life and complications due to long term infusion of opioids in the lumbar subarachnoid space in 11 patients with non cancer pain were the goals of this study. Patients were previously treated with drugs and surgical procedures, without significant pain relief. Patients were asked to compare pain characteristics and daily life activities before and after this treatment. The long term

  15. Tratamiento con enjuagues de ketamina asociado o no a fentanilo transmucoso en el dolor oncológico orofacial resistente a opiáceos mayores

    OpenAIRE

    2015-01-01

    Objetivo: Evaluar la efectividad de los enjuagues de ketamina asociados o no a fentanilo transmucoso en una serie de diversos dolores orofaciales de etiología neoplásica de difícil control analgésico. Material y métodos: Estudio prospectivo de 20 pacientes, con 8 pacientes que recibieron enjuagues de ketamina (40 mg = 4 ml), 8 pacientes que recibieron ketamina asociada a citrato de fentanilo por vía transmucosa oral a dosis de 200 mcg y 4 pacientes con opiáceos sistémicos para el dolor oro...

  16. Diagnostyczna funkcja arteterapii na oddziale psychiatrycznym dla młodzieży – opis przypadku

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    Agnieszka Gmitrowicz

    2012-09-01

    Full Text Available Opis przypadku klinicznego dotyczy analizy dynamiki obrazu psychopatologicznego u pacjentki hospitalizowanej w Klinice Psychiatrii Młodzieżowej, w kontekście twórczości spontanicznej oraz inspirowanej w trakcie indywidualnych zajęć arteterapii. Proces rediagnozy – z choroby afektywnej dwubiegunowej na zaburzenia schizoafektywne – został zapoczątkowany w toku omawiania prac plastycznych pacjentki. W jej twórczości podczas kolejnej fazy depresyjnej bez objawów psychotycznych zaczęły występować: cechy znacznej dezorganizacji, symbole, deformacja postaci, kontaminacje, nieuzasadnione treścią podziały przestrzeni, zachwiania perspektywy, o kilka miesięcy wyprzedzające rozwój pełnoobjawowej psychozy o obrazie schizofrenii. Osiemnastoletnia pacjentka, chorująca od roku, początkowo była leczona z powodu manii w przebiegu choroby afektywnej dwubiegunowej. Prezentowała podwyższony nastrój i napęd, przyspieszony tok myślenia, wypowiadała urojenia wielkościowe, posłannicze, skracała dystans, relacjonowała „wyostrzenie zmysłów”, „poszerzenie świadomości”, chciała „nieść światu piękno”. Relacjonowała, że od dawna obserwuje u siebie wahania nastroju – od stanów „depresji” z uczuciem smutku, wyczerpania, anhedonii, nadmierną sennością, znacznym spadkiem aktywności, myślami samobójczymi do stanów „euforii”, „hiperaktywności”. Krótko po wypisie pacjentka odstawiła leki i po kilku miesiącach trafiła ponownie na oddział z objawami epizodu depresji i tendencjami samobójczymi. W trakcie tej hospitalizacji pacjentce zaproponowano udział w indywidualnych zajęciach arteterapeutycznych z uwagi na jej spontaniczną twórczość plastyczną (w tym malowanie na ścianach oraz odmowę udziału w zajęciach grupowych. Zespół terapeutyczny, w skład którego wchodziła arteterapeutka, określił następujące cele arteterapii: diagnostyczny, komunikacyjny, integracyjny i katartyczny

  17. Literatura, toxicomanías y psicoanálisis : Una lectura de Confesiones de un opiófago ingles

    OpenAIRE

    Romero, Laura

    2014-01-01

    El presente escrito propone una lectura de uno de los textos de Thomas De Quincey, titulado: Confesiones de un opiófago inglés: Extracto de la vida de un académico; libro escrito por el académico en el año 1836, con un interés declarado en que resulte un relato “útil e instructivo” para sus lectores. Luego de situar una relación posible del psicoanálisis con la literatura, mi comentario recorta algunos de los puntos en los cuales De Quincey nos abre camino a la hora de pensar en una clínica p...

  18. AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovora.

    Science.gov (United States)

    Pletzer, Daniel; Schweizer, Gabriel; Weingart, Helge

    2014-09-01

    Transcriptional regulators of the AraC/XylS family have been associated with multidrug resistance, organic solvent tolerance, oxidative stress, and virulence in clinically relevant enterobacteria. In the present study, we identified four homologous AraC/XylS regulators, Rob, SoxS, PliA, and OpiA, from the fire blight pathogen Erwinia amylovora Ea1189. Previous studies have shown that the regulators MarA, Rob, and SoxS from Escherichia coli mediate multiple-antibiotic resistance, primarily by upregulating the AcrAB-TolC efflux system. However, none of the four AraC/XylS regulators from E. amylovora was able to induce a multidrug resistance phenotype in the plant pathogen. Overexpression of rob led to a 2-fold increased expression of the acrA gene. However, the rob-overexpressing strain showed increased resistance to only a limited number of antibiotics. Furthermore, Rob was able to induce tolerance to organic solvents in E. amylovora by mechanisms other than efflux. We demonstrated that SoxS from E. amylovora is involved in superoxide resistance. A soxS-deficient mutant of Ea1189 was not able to grow on agar plates supplemented with the superoxide-generating agent paraquat. Furthermore, expression of soxS was induced by redox cycling agents. We identified two novel members of the AraC/XylS family in E. amylovora. PliA was highly upregulated during the early infection phase in apple rootstock and immature pear fruits. Multiple compounds were able to induce the expression of pliA, including apple leaf extracts, phenolic compounds, redox cycling agents, heavy metals, and decanoate. OpiA was shown to play a role in the regulation of osmotic and alkaline pH stress responses.

  19. Eiríkur Bergmann Einarsson: Opið land: Staða Íslands í samfélagi þjóðanna

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    Magnús Árni Magnússon

    2007-06-01

    Full Text Available Opið land, staða Íslands í samfélagi þjóðanna, eftir Eirík Bergmann Einarsson kom út á vegum bókaforlagsins Skruddu á vormánuðum 2007. Eiríkur er forstöðumaður Evrópufræðaseturs á Bifröst og dósent í stjórnmálafræði við félagsvísindadeild skólans. Hann hefur í á annan áratug fjallað um Evrópumál - og ekki síður þjóðmál - á opinberum vettvangi, sem pistlahöfundur í dagblöðum og tímaritum, sem álitsgjafi í fréttum, sem talsmaður Evrópusambandsins á Íslandi, (en Eiríkur er einn fárra Íslendinga sem hafa starfað fyrir það, svo og bæði sem stjórnmálamaður (Eiríkur var varaþingmaður Samfylkingarinnar kjörtímabilið 2003-2007 og sem fræðimaður. Opið land er fjórða bók höfundar, en fyrri bækur eru Ísland í Evrópu, Evrópuúttekt Samfylkingarinnar 2001, sem Eiríkur ritstýrði, Evrópusamruninn og Ísland, sem kom út á vegum Háskólaútgáfunnar 2003 og Glapræði, sem er skáldsaga og kom út á vegum áðurnefndrar Skruddu 2005.

  20. The Effectiveness of Diagnostic Assessment on the Development of Turkish Language Learners’ Narrative Skills as an Oral Proficiency Interview (OPI Task

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    Anjel Tozcu

    2016-07-01

    Full Text Available This study investigated the effectiveness of diagnostic assessment on improving students’ proficiency in narrating past events, an Oral Proficiency Interview (OPI Level 2 task. It found that students who were given a personalized learning plan subsequent to the diagnostic assessment interview significantly improved their proficiency in basic sentence structures than those in a control group. They used a significantly larger number of cohesive devices as compared to the control group and exhibited significantly increased accuracy in using cohesive devices than a control group. The students in the treatment group worked on the recommended activities based on the data gathered during the diagnostic assessment interview and the pre-interview questionnaires, i.e., the E & L, MBTI, and Barsch. The students in the control group spent the same amount of time reading narrations, doing comprehension exercise,s and following standard teacher feedback for improvement. Although both groups showed increases in accurate use of cohesive devices and proficiency in basic sentence structures, the treatment students showed significantly greater gains than the control students.

  1. Manejo del dolor crónico en Atención Primaria, perfil de prescripción de opiáceos mayores: indicación, coste y efectos secundarios

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    M. Guzmán-Ruiz

    2014-08-01

    Full Text Available Objetivos: el objetivo principal del estudio es conocer las características de la prescripción de opiáceos mayores en Atención Primaria. Material y métodos: se diseña un estudio retrospectivo mediante una cohorte histórica, valorando a los pacientes que hayan consumido opiáceos mayores en todos los centros de salud de Jaén capital durante 2011, mediante un muestreo sistemático, 215 pacientes, calculando el tamaño de muestra para un nivel de confianza 95 %, precisión 5 %, y pérdidas 5 % (ampliando la muestra este 5 % por sesgo de información; Se auditan las historias clínicas recogiendo: edad, sexo, antecedentes personales, nivel social, frecuentación sanitaria, características de la prescripción de opiáceos (dosis, duración, coste, efectos secundarios y uso de otros analgésicos/coadyuvantes. Se procesan los datos para ofrecer un estudio descriptivo y una posterior comparación en función del opiáceo prescrito. Resultados: se valoran 215 pacientes (44 % del total de la población, de los que se obtienen 323 prescripciones de opiáceos en el año de estudio (23 % de la muestra con dos prescripciones de opiáceos y 13 % con tres. Los opiáceos más prescritos son fentanilo (60 % y buprenorfina (22%, por un 3 % de morfina. La buprenorfina es el más usado en monoterapia (70 %, preferentemente en mujeres de edad avanzada y pensionistas, sobre todo para el dolor mixto por parte del médico de familia. El fentanilo se usa principalmente en parches (95 % de las prescripciones de fentanilo y la hidromorfona se emplea en pacientes de menor edad (< 60 años, prescrito por la Unidad del Dolor y Reumatología (43 % y 20 % del total de prescripciones, respectivamente. La oxicodona se emplea más en pacientes de zonas necesitadas de transformación social (46 % del total de opioides prescritos en ZNTS y exclusivamente para el dolor neuropático y mixto (52 % y 48 % respectivamente de las prescripciones totales de oxicodona, sobre todo

  2. Multi-drug resistance gene (MDR1 and opioid analgesia in horses Gene de resistência múltipla aos fármacos e analgesia opióide em eqüinos

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    Cláudio Corrêa Natalini

    2006-02-01

    Full Text Available Opioid absorption in the intestinal tract as well as its effects in the central nervous system is modulated by the P-glycoprotein (P-gp encoded in the Multi-drug Resistance gene (MDR1 also named ATP-binding cassete, subfamily B, member 1 (ABCB1. This MDR1 gene acts as a selective pump. The expression of this protein in humans and rodents inhibits cellular uptake of substrate opioids. The presence of the intestinal iso-enzyme CYP3A4 associated with MDR1 gene decreases the opioid analgesic activity due to an increase in intestinal metabolism, with a predicted intestinal first pass extraction around 20% which significantly influences the oral availability of opioids. In the central nervous system, P-gp expression decreases opioid neuronal uptake diminishing the analgesic effects. It is unknown if horses have the MDR1 gene and P-gp and what are the effects on opioid absorption, metabolism, and analgesia. Identifying the MDR1 gene and P-gp status in horses is of great importance in order to better understand opioid pharmacologic effects in horses.A absorção de opióides no trato intestinal, assim como seus efeitos no sistema nervoso central, são modulados pela P-glicoproteína (P-gp, uma proteína de membrana celular codificada pelo gene MDR1, também chamado ATP-binding cassete, subfamília B, membro 1 (ABCB1 e que atua como bomba seletiva. A expressão desta proteína em roedores e seres humanos inibe a absorção celular de opióides e sua presença no intestino associada à isoenzima CYP3A4 reduz a atividade analgésica dos opióides por ativação do metabolismo intestinal do fármaco. A redução na extração intestinal de fármacos opióides susceptíveis a esta proteína chega a 20%, o que reduz significativamente a biodisponibilidade de opióides administrados por via oral. No sistema nervoso central, a P-gp diminui a captação neuronal dos opióides e seus efeitos analgésicos. Ainda é desconhecido se o gene MDR1 e a P-gp est

  3. First report on spinal hyperbaric opioids in horses Primeiro relato do uso de opióide hiperbárico por via espinhal em cavalos

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    Alexandre da Silva Polydoro

    2006-02-01

    Full Text Available This study is the first to report the use of spinal hyperbaric opioids in horses injected through a lumbar-sacral subarachnoid catheter. The injection of hyperbaric subarachnoid morphine and methadone produced short term intense analgesia over the dermatomes of the perineal, sacral, lumbar, and thoracic areas without cardiorespiratory depression, ataxia or central nervous system excitement. The technique involves the use of 10% dextrose as a hyperbaric solvent producing an average hyperbaric solution with a specific gravity of 1030. The use of spinal hyperbaric opioids in horses can be recommended for short term moderate to severe pain management in this species.Este estudo relata pela primeira vez o uso de opioide hiperbárico por via espinhal em cavalos, administrado através de um cateter subaraquenóide lombo-sacro. Foi demonstrado que a administração de morfina ou metadona hiperbáricos em solução de dextrose 10% produz analgesia intensa e de curta duração sobre os dermatomas perineais, sacrais, lombares e torácicos, sem depressão cardiorrespiratória, ataxia ou excitação do sistema nervoso central. A técnica descrita, neste estudo, produziu soluções com gravidade específica de 1030. O uso de solução hiperbárica de opióides pode ser recomendado para obtenção de analgesia intensa de curta duração no cavalo.

  4. Estudio de utilización de analgésicos opiáceos en un hospital general universitario Study of opioid analgesic use in a general university hospital

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    P. Gómez Salcedo

    2009-10-01

    Full Text Available Objetivo: El objetivo de este trabajo ha sido realizar un estudio de utilización de analgésicos opiáceos en el Hospital Universitario La Paz (Madrid en el año 2008 para conocer cómo se está utilizando este grupo de medicamentos y cuál es la tendencia del consumo. Para ello, se presentan los datos de uso de opiáceos en pacientes ingresados de forma global, por hospitales y por servicios clínicos. Se exponen los datos de consumo de los 5 últimos años y se ha cuantificado el uso del resto de principios activos empleados como analgésicos en nuestro hospital. Material y métodos: Haciendo uso de la metodología recomendada por la Organización Mundial de la Salud para los estudios de utilización de medicamentos en hospitales, presentamos nuestros datos en dosis diarias definidas (DDD por 100 estancias. Los datos de consumo se han obtenido del programa de gestión de medicamentos del Servicio de Farmacia Farma Tools (Dominion® Resultados: El valor global de utilización de opiáceos en 2008 ha sido de 8,1 DDD/100 estancias. Los principios activos más consumidos han sido la morfina parenteral y el fentanilo transdérmico, y entre los 2 representan el 83% del consumo total de opiáceos. En el análisis por hospitales apreciamos que el Hospital General y el de Traumatología son los que presentan un mayor empleo de opiáceos y siguen el mismo patrón de utilización que el global. Los servicios más representativos del consumo de opiáceos han sido las reanimaciones del Hospital General y de Traumatología, los Servicios de Oncología, Cuidados paliativos y Hematología. En estos últimos 5 años se ha producido un incremento global del consumo de aproximadamente el 20%, viéndose implicados todos los principios activos. Con relación al consumo total de analgésicos, los datos reflejan una amplia utilización en el hospital (104 DDD/100 estancias. Los opiáceos representan un 7,4% del consumo total de analgésicos, siendo el paracetamol y

  5. Lumbalgia y ciática crónicas: ¿Usamos adecuadamente los opiáceos? ¿Cirugía de raquis o morfina en el paciente mayor?

    Directory of Open Access Journals (Sweden)

    F. J. Robaina Padrón

    2009-02-01

    Full Text Available La literatura especializada está enviando señales de alarma que se extienden por diferentes organizaciones relacionadas con el estudio y tratamiento del dolor no oncológico y, concretamente, con el manejo farmacológico a largo plazo del dolor de origen lumbar. En este artículo de opinión se intenta llamar la atención acerca de los problemas derivados del uso de los opiáceos potentes a largo plazo para controlar el dolor persistente por enfermedad degenerativa lumbar así como estudiar las relaciones entre la medicación opiácea y la cirugía en este tipo de patología. Las unidades encargadas de realizar este tipo de cirugía en el paciente mayor, por ahora, parece que, en general, no han aceptado o no son muy proclives a la utilización de las técnicas mínimamente invasivas para la cirugía de la columna, obligando a muchos pacientes mayores a someterse a tratamientos prolongados con opiáceos potentes. Publicaciones recientes nos alertan del riesgo de adicción de un tratamiento prolongado con opiáceos, el cual oscila entre el 5-24%. Hay un claro riesgo para los pacientes, para la sociedad en general y para los médicos. Las visitas a los servicios de urgencia relacionadas con el uso del fentanilo han aumentado 50 veces entre los años 1994 y 2002. Se han detectado fallos en los profesionales sanitarios para mantenerse al día en el conocimiento y en el desarrollo de las habilidades precisas para ofrecer buenos tratamientos a sus pacientes (culpabilidad de la ignorancia. Los opiáceos pueden activar mecanismos neurofisiológicos pronociceptivos creando una situación de aumento de sensibilidad al dolor, que ha pasado a denominarse hiperalgesia inducida por opiáceos (HIO. Es muy probable que la disminución en la eficacia analgésica a largo plazo se deba a un fenómeno de HIO. Entre el 18 y el 41% de los pacientes puede estar cayendo en abuso de estos medicamentos. Se ha detectado un incremento del 91,2% en las muertes asociadas

  6. Factores determinantes en las OPI

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    Rodriguez, M.P.

    2008-01-01

    Full Text Available The effect of “underpricing” is closely related to the difference of the price set up in the IPO and the closing price of its first day of trading. This concept has been studied internationally for more than 3 decades and it is lately relevant to emerging countries, particularly in the stock markets in which double digit growth has been an important factor such as the Mexican Stock Market. Here we will find some theoretical studies as well as some behaviors in this matter regarding companies in their first public offer. This article does not pretend to be exhaustive but to bring relevance of several studies and theories, to relate variables in international context to the Mexican Stock Market. Further more, conclusions and follow-up actions in this investigation will aim to have a successful initial public offer.

  7. Współistnienie linijnej IgA dermatozy pęcherzowej z atopowym zapaleniem skóry. Trudności diagnostyczne. Opis przypadku

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    Marcin Zakrzewski

    2011-12-01

    Full Text Available Wprowadzenie: Linijna IgA dermatoza pęcherzowa (ang. linear IgAbullous dermatosis – LABD jest przewlekłą autoimmunologiczną chorobąpęcherzową skóry, która niezwykle rzadko współistnieje z innymischorzeniami. Cel pracy: Przedstawienie wyjątkowo rzadkiego współistnienia LABDz atopowym zapaleniem skóry (AZS. Opis przypadku: Kobieta, lat 28, zgłosiła się do poradni dermatologicznejz powodu rozsianych na skórze całego ciała, układających sięobrączkowato zmian pęcherzowych na rumieniowym podłożu oraznadżerek w obrębie błon śluzowych jamy ustnej. Poza tym na skórzetwarzy, nadgarstków oraz w zgięciach łokciowych stwierdzano zmianytypowe dla AZS. Pacjentka od wczesnego dzieciństwa choruje naAZS, idiopatyczną nadpłytkowość oraz obecnie na bezobjawowewrzodziejące zapalenie jelita grubego. U matki kobiety rozpoznanostwardnienie rozsiane. W badaniu immunofluorescencyjnym bezpośrednimwycinka skóry wykazano obecność linijnych złogów IgA nagranicy skórno-naskórkowej, za pomocą badania immunofluorescencyjnegopośredniego nie stwierdzono obecności przeciwciał reagującychz błoną podstawną, a metodą ELISA przeciwciał anty-NC16A. Napodstawie obrazu klinicznego oraz wykonanych badań rozpoznanoLABD, co dodatkowo potwierdzono badaniem wycinka skóry metodąmikroskopii konfokalnej. Ze względu na nadpłytkowość pacjentkabyła konsultowana hematologicznie i miała wykonaną biopsję szpiku.Rozpoznano u niej nadpłytkowość idiopatyczną. Pomimo zaburzeńhematologicznych podjęto leczenie prednizonem w dawkach zmniejszającychsię (od 40 mg/dobę oraz enoksaparyną. Podczas terapiiobserwowano systematyczną poprawę kliniczną, pęcherze wchłonęłysię, pozostawiając pozapalne przebarwienia. Przy redukcji dawki prednizonuobserwowano stopniowe pogarszanie się zmian skórnych typowychdla AZS, zwłaszcza w obrębie twarzy i kończyn górnych. Z tegowzględu włączono leczenie cyklosporyną A. Wnioski

  8. Diretrizes para o tratamento de pacientes com síndrome de dependência de opióides no Brasil Brazilian guideline for the treatment of patients with opioids dependence syndrome

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    Danilo Antonio Baltieri

    2004-12-01

    Full Text Available Existe uma prevalência relativamente baixa do uso de ópioides no Brasil, em particular envolvendo o uso não médico da codeína e de xaropes que contêm opióides. No entanto, a síndrome de dependência apresenta um significativo impacto total na mortalidade e morbidade. Nos últimos 20 anos, o avanço científico tem modificado nosso entendimento sobre a natureza da adição aos opióides e os variados tratamentos possíveis. A adição é uma doença crônica tratável se o tratamento for realizado e adaptado tendo em vista as necessidades do paciente específico. Há, de um fato, um conjunto de tratamentos que podem efetivamente reduzir o uso da droga, ajudar a gerenciar a fissura pela droga, prevenir recaídas e recuperar as pessoas para o funcionamento social produtivo. O tratamento da dependência de drogas será parte de perspectivas de longo prazo do ponto de vista médico, psicológico e social. Esta diretriz almeja fornecer um guia para os psiquiatras e outros profissionais de saúde que tratam de pacientes com Síndrome de Dependência de Opióides. Ela tece comentários sobre o tratamento somático e psicossocial que é utilizado nesses pacientes e revisa as evidências científicas e seu poder. Da mesma forma, os aspectos históricos, epidemiológicos e neurobiológicos da dependência de opióides são revisados.There is a relatively low prevalence of opioid use in Brazil, particularly involving the non-medical use of codeine and opiate-containing syrups. However, opioid dependence syndrome shows a significant total impact on mortality and morbidity. Over the past 20 years, scientific progress has changed our understanding of the nature of opioid addiction and its various possible treatments. Addiction is a chronic illness treatable if the treatment is well-delivered and tailored to the needs of the particular patient. There is indeed an array of treatments that can effectively reduce drug use, help manage drug cravings

  9. Uma breve história do ópio e dos opióides Una historia breve del opio y de los opioides Opium and opioids: a brief history

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    Danilo Freire Duarte

    2005-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Desde tempos imemoriais, o ópio e os seus derivados, além de exercerem ponderável influência sobre o comportamento dos seres humanos, têm sido empregados como sedativo e como analgésico. A partir do século XIX, com o isolamento dos alcalóides do ópio e as facilidades para o emprego dessas substâncias por via parenteral, houve aumento do interesse pelo uso criterioso dos opióides na área médica e da análise das conseqüências sociais de seu uso abusivo. Justifica-se, pelo exposto, uma revisão histórica do ópio e dos seus derivados. CONTEÚDO: A evolução dos conhecimentos sobre o ópio, produto natural extraído do Papaver somniferum, e sobre os opióides, substâncias naturais, semi-sintéticas e sintéticas extraídas do ópio, bem como as principais referências a essas substâncias desde a Antigüidade foram avaliadas. Foi enfatizado o progresso obtido a partir dos trabalhos de Setürner que resultaram no isolamento da morfina. As investigações conduzidas por outros autores na busca de substâncias sintéticas que apresentassem vantagens sobre os produtos naturais foram mencionadas. A importância da descoberta dos receptores opióides e de seus ligantes endógenos foi sublinhada. CONCLUSÕES: No alvorecer do terceiro milênio, a despeito das pesquisas realizadas com drogas analgésicas de outros grupos farmacológicos, os opióides continuam sendo os analgésicos mais potentes, embora sua eficácia seja contestada em certos tipos de dor. Os atuais conhecimentos de Farmacologia Clínica permitem selecionar o opióide a ser administrado, considerando a doença e as condições do paciente, na busca da melhor relação custo-benefício.JUSTIFICATIVA Y OBJETIVOS: Desde tiempos inmemoriales, el opio y sus derivados, junto con ejerceren ponderable influencia sobre el comportamiento de los seres humanos, han sido empleados como sedante y como analgésico. Desde el siglo XIX, con el aislamiento de los

  10. Przebieg wczesnej rehabilitacji po udarze mózgu i ostrym zespole wieńcowym u chorego z przebytą obustronną amputacją podudzi. Opis przypadku

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    Michał Starosta

    2015-08-01

    Full Text Available Wstęp: Udar niedokrwienny mózgu jako powikłanie ostrego zespołu wieńcowego występuje w około 1,40% przypadków. Kompleksowa rehabilitacja jest niezbędnym elementem leczenia osób po udarze. Opis przypadku: Prezentowany przypadek kliniczny dotyczy pacjenta po udarze mózgu poprzedzonym ostrym zespołem wieńcowym; w przeszłości chory przebył obustronną amputację podudzi. Praca przedstawia przebieg 25-dniowego programu rehabilitacji psychoruchowej, którą prowadzono na oddziale rehabilitacji neurologicznej. Metody: Skuteczność zastosowanego leczenia oceniono za pomocą skal funkcjonalnych (skala czynności życia codziennego, zmodyfikowana skala Rankina, Skala Udaru Narodowego Instytutu Zdrowia, Ocena Motoryczności Rivermead i psychologicznych (Geriatryczna Skala Oceny Depresji Yesavage’a, Krótka Skala Oceny Stanu Umysłowego. Wyniki: Poprawa funkcjonalna dotyczyła przede wszystkim kończyny górnej i ruchów globalnych. Zmniejszyło się nasilenie zaburzeń depresyjnych (21 versus 11 punktów w Geriatrycznej Skali Oceny Depresji Yesavage’a. Znormalizowały się wyniki uzyskiwane przez pacjenta w Krótkiej Skali Oceny Otępień (19 versus 27 punktów. Wnioski: Wcześnie zastosowany indywidualny program rehabilitacji wraz z intensywną terapią psychologiczną to bardzo ważny element leczenia osób z wieloczynnikowym obniżeniem sprawności ruchowej.

  11. O papel dos antagonistas periféricos dos opióides no tratamento da dor e nos cuidados perioperatórios El papel de los antagonistas periféricos de los opioides en el tratamiento del dolor y en los cuidados perioperatorios The role of peripheral opiate antagonists in pain medicine and perioperative care

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    Pedro Paulo Tanaka

    2008-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Estudos clínicos e pré-clínicos sobre os antagonistas periféricos dos opióides aumentaram nosso conhecimento sobre os efeitos dos opióides exógenos e endógenos. CONTEÚDO: Este artigo faz uma revisão dos estudos clínicos e pré-clínicos sobre a disfunção intestinal secundária ao uso de opióides. CONCLUSÕES: Se forem aprovados, esses fármacos podem representar soluções importantes para os problemas encontrados na prática médica com relação ao tratamento da dor.JUSTIFICATIVA Y OBJETIVOS: Estudios clínicos y preclínicos sobre los antagonistas periféricos de los opioides aumentaron nuestro conocimiento sobre los efectos de los opioides exógenos y endógenos. CONTENIDO: Este artículo nos trae una reflexión de los estudios clínicos y preclínicos sobre la disfunción intestinal secundaria al uso de opioides. CONCLUSIONES: Si se aprueban, los referidos fármacos pueden representar soluciones importantes para los problemas encontrados en la práctica médica en relación con el tratamiento del dolor.BACKGROUND AND OBJECTIVES: Pre-clinical and clinical trials of peripheral opiate antagonists have shed new light on the effects of exogenous and endogenous opioids. CONTENTS: This article review preclinical studies and clinical opioid bowel disfunction trials. CONCLUSIONS: If approved these drugs may offer potential solutions to important clinical problems in pain management.

  12. Lumbalgia y ciática crónicas: ¿Usamos adecuadamente los opiáceos? ¿Cirugía de raquis o morfina en el paciente mayor? Chronic lumbar and sciatic pain: Are we using opioids correctly? Spinal surgery vs morphine in the elderly

    OpenAIRE

    F.J. Robaina Padrón

    2009-01-01

    La literatura especializada está enviando señales de alarma que se extienden por diferentes organizaciones relacionadas con el estudio y tratamiento del dolor no oncológico y, concretamente, con el manejo farmacológico a largo plazo del dolor de origen lumbar. En este artículo de opinión se intenta llamar la atención acerca de los problemas derivados del uso de los opiáceos potentes a largo plazo para controlar el dolor persistente por enfermedad degenerativa lumbar así como estudiar las rela...

  13. Personnel Investigations and Clearance Tracking (OPI)

    Data.gov (United States)

    Office of Personnel Management — Security file-related information for the U.S. Office of Personnel Management (OPM)'s employee and contractor personnel. The data is OPM-specific, not government-wide.

  14. Samouszkodzenia jako symptom prodromalny schizofrenii. Opis przypadku

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    Konstantinos Tsirigotis

    2010-06-01

    Full Text Available Celem pracy było przedstawienie przypadku chorego na schizofrenię, który przed ostatecznym zdiagnozowaniem schizofrenii dokonywał samouszkodzeń. Pacjentem był student w wieku 23 lat, a powodem zgłoszenia do psychologa samouszkodzenie. Zgłosił się z matką, zaniepokojoną jego czynem. Pacjent był zorientowany prawidłowo co do miejsca, czasu i własnej osoby, w kontakcie pozornie dobrym. Na lewym ramieniu widać było ranę ciętą. Odczuwał stany agresji, co było powodem dokonywania samouszkodzeń. Prowadził nocny tryb życia, wówczas inni ludzie nie przeszkadzali mu. Jego wypowiedzi były logiczne, zborne, brak było oznak zaburzeń myślenia. Nie sprawiał wrażenia przejętego swoimi przeżyciami i tym, co się z nim dzieje; wyrażane przez niego emocje nie były dostosowane do treści jego wypowiedzi. Jego profil w MMPI był „nerwicowy”, ale inne wskaźniki (kliniczne, diagnostyczne i różnicowe nasuwały podejrzenie psychozy. Dane z wywiadu, rozmowy, obserwacji i MMPI sprawiły, że pacjent został skierowany do psychiatry z podejrzeniem zaburzeń schizofrenicznych. O objawach pozytywnych (produktywnych zaczął mówić dopiero przy analizie treściowej pozycji krytycznych MMPI. Rozpoznanie psychiatryczne potwierdziło podejrzenia schizofrenii; został hospitalizowany i był leczony z rozpoznaniem schizofrenii paranoidalnej. W tym przypadku początek schizofrenii był powolny, ubogoobjawowy, bez objawów ostrych. Przedchorobowa osobowość pacjenta nosiła cechy schizotymii, autystycznego izolowania się – najprawdopodobniej była to już osobowość schizoidalna. Zagadnienie izolowania się można rozpatrywać również w kategoriach zapotrzebowania na stymulację i optimum stymulacji. Odrębnym zagadnieniem są związki samouszkodzeń z substancjami (endorfiny, encefaliny itp. wydzielanymi podczas tego typu autostymulacji. Powyższe dane potwierdzają jeszcze raz znaczenie diagnozy klinicznej (w odróżnieniu od psychometrycznej i wagę jakościowej, klinicznej interpretacji danych psychometrycznych, testowych.

  15. Lumbalgia y ciática crónicas: ¿Usamos adecuadamente los opiáceos? ¿Cirugía de raquis o morfina en el paciente mayor? Chronic lumbar and sciatic pain: Are we using opioids correctly? Spinal surgery vs morphine in the elderly

    Directory of Open Access Journals (Sweden)

    F. J. Robaina Padrón

    2009-02-01

    Full Text Available La literatura especializada está enviando señales de alarma que se extienden por diferentes organizaciones relacionadas con el estudio y tratamiento del dolor no oncológico y, concretamente, con el manejo farmacológico a largo plazo del dolor de origen lumbar. En este artículo de opinión se intenta llamar la atención acerca de los problemas derivados del uso de los opiáceos potentes a largo plazo para controlar el dolor persistente por enfermedad degenerativa lumbar así como estudiar las relaciones entre la medicación opiácea y la cirugía en este tipo de patología. Las unidades encargadas de realizar este tipo de cirugía en el paciente mayor, por ahora, parece que, en general, no han aceptado o no son muy proclives a la utilización de las técnicas mínimamente invasivas para la cirugía de la columna, obligando a muchos pacientes mayores a someterse a tratamientos prolongados con opiáceos potentes. Publicaciones recientes nos alertan del riesgo de adicción de un tratamiento prolongado con opiáceos, el cual oscila entre el 5-24%. Hay un claro riesgo para los pacientes, para la sociedad en general y para los médicos. Las visitas a los servicios de urgencia relacionadas con el uso del fentanilo han aumentado 50 veces entre los años 1994 y 2002. Se han detectado fallos en los profesionales sanitarios para mantenerse al día en el conocimiento y en el desarrollo de las habilidades precisas para ofrecer buenos tratamientos a sus pacientes (culpabilidad de la ignorancia. Los opiáceos pueden activar mecanismos neurofisiológicos pronociceptivos creando una situación de aumento de sensibilidad al dolor, que ha pasado a denominarse hiperalgesia inducida por opiáceos (HIO. Es muy probable que la disminución en la eficacia analgésica a largo plazo se deba a un fenómeno de HIO. Entre el 18 y el 41% de los pacientes puede estar cayendo en abuso de estos medicamentos. Se ha detectado un incremento del 91,2% en las muertes asociadas

  16. Clínicas del dolor y cuidados paliativos en México: manejo del estreñimiento inducido por opiáceos. Conclusiones de un grupo de expertos Pain clinics and palliative care in Mexico: management of opioid-induced constipation. Conclusions of an expert group

    Directory of Open Access Journals (Sweden)

    J.A. Flores Cantisani

    2009-12-01

    Full Text Available A finales de septiembre de 2008, 15 líderes de opinión en el tratamiento del dolor y los cuidados paliativos de México se reunieron en la ciudad de México con el objetivo de elaborar una guía clínica acerca del uso de opiáceos y sus efectos secundarios, con especial acento en el estreñimiento, y se propuso un nuevo esquema de tratamiento. Los participantes trabajan actualmente en unidades de dolor o de paliativos por todo México y algunos son participante activos en la elaboración de medidas reguladoras sobre el uso de opiáceos. Durante la elaboración de esta guía, se ha publicado la Ley de Reforma del Tratamiento Paliativo de México, que ha entrado en vigor el 6 de enero de 2009.At the end of September 2008, 15 leading figures in pain treatment and palliative care in Mexico met in Mexico City to design a clinical guideline on the use of opioids and the secondary effects of these drugs, with special emphasis on constipation. A new treatment scheme was proposed. The participants currently work in pain or palliative care units throughout Mexico and some are active participants in the design of regulatory measures on opioid use. During the drafting of this guideline, the law reforming palliative treatment in Mexico was passed and came into effect on 6th January, 2009.

  17. O uso de opióides no tratamento da dor crônica não oncológica: o papel da metadona El uso de opioides en el tratamiento del dolor crónico no oncológica: el papel de la metadona Opioids for treating non malignant chronic pain: the role of methadone

    Directory of Open Access Journals (Sweden)

    Sady Ribeiro

    2002-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O uso de opióides em dor oncológica já é bastante difundido e comprovado por diversos ensaios clínicos bem controlados. Entretanto, há uma grande controvérsia em relação ao uso em longo prazo de opióides em dor crônica de origem não oncológica, que tem se intensificado de forma importante nos últimos anos. Neste estudo, objetivamos avaliar criticamente as informações disponíveis na literatura a respeito do uso de opióides para tratamento de dor crônica não oncológica e o papel da metadona como opção terapêutica. CONTEÚDO: Os estudos disponíveis ainda são limitados, mas demonstram que determinadas subpopulações de pacientes portadores de dor crônica podem alcançar analgesia importante, com pouca tolerância e baixo potencial para adição, principalmente aqueles refratários aos esquemas terapêuticos convencionais. Morfina é o opióide padrão, mas outras alternativas podem ser utilizadas como oxicodona, hidromorfona ou fentanil. Metadona é um opióide sintético, inicialmente utilizado para prevenir síndrome de abstinência em paciente dependentes, que também constitui uma importante opção no tratamento da dor crônica não oncológica, principalmente dor neuropática. CONCLUSÕES: Apesar do conhecimento crescente sobre o uso de opióides em dor crônica não oncológica, novos estudos melhor controlados ainda são necessários para uma discussão mais científica a respeito do assunto. A metadona administrada por via oral apresenta uma boa relação custo-benefício, representando uma alternativa efetiva para um melhor controle da dor em alguns pacientes.JUSTIFICATIVA Y OBJETIVOS: El uso de opioides en el dolor oncológico ya es bastante difundido y comprobado por diversos ensayos clínicos bien controlados. Entretanto, hay una grande controversia en relación con el uso en largo plazo de opioides en el dolor crónico de origen no oncológica, que se ha intensificado de forma

  18. Rumień guzowaty u dziecka – opis przypadku

    Directory of Open Access Journals (Sweden)

    Bożena Chodynicka

    2011-08-01

    Full Text Available Introduction. Erythema nodosum belongs to a group of diseases connectedwith subcutaneous tissue inflammation. It occurs mainly in people20-40 years of age, more frequently in women. Typical changesappear as inflammatory nodules on the frontal surface of lower legs.There is a significant influence of streptococcal infections on erythemanodosum appearance.Objective. To present a case of erythema nodosum in a child caused bytonsillitis.Case report. A 9-year old girl was admitted to the Department withnumerous, tender, red nodules on the anterior parts of the lower legs.Physical examinations revealed hypertrophy of tonsils. Laboratoryexaminations showed increased erythrocyte sedimentation rate,increased level of C-reactive protein and anti-streptolysin O (ASO. Aftersystemic and topical treatment, significant improvement was achieved.Conclusions. In cases of erythema nodosum in children, it is important toexclude infections of the upper respiratory tract and to carry out theproper treatment.

  19. Vanha koira ei opi uusia temppuja / Lasse Lehtinen

    Index Scriptorium Estoniae

    Lehtinen, Lasse

    2008-01-01

    Euroopa Parlamendi liige Eesti ja Soome välispoliitika erinevustest Venemaa suhtes. Autor tsiteerib katkendeid artiklist: Ilves, Toomas Hendrik. Meloslaisia muistellen. Kanava, 2008, nr. 8, lk. 640-646

  20. Los Organismos Públicos de Investigación (OPIS

    Directory of Open Access Journals (Sweden)

    López Facal, Javier

    1998-05-01

    Full Text Available Not available.El sistema español de I+D está siendo objeto de atención, tanto por parte del Gobierno de la Nación, como por parte de los agentes sociales y de instituciones privadas. Con el fin de aportar datos y reflexiones a este debate, se presenta en este artículo un informe sobre los Organismos Públicos de Investigación en el que se trata de su régimen presupuestario, su estatus jurídico, sus efectivos humanos, su producción científica y tecnológica y su actividad investigadora, y se ofrecen sugerencias para una mayor homologación de estos organismos.

  1. Rejecting the OPI--Again: A Response to Hagen.

    Science.gov (United States)

    Lantolf, James P.; Frawley, William

    1992-01-01

    Addresses the effectiveness of the oral proficiency interview in assessing foreign language skills, responding to arguments regarding the logic of the interview method, the American Council on the Teaching of Foreign Languages (ACTFL) guidelines and levels of proficiency, and the relationship between linguistic knowledge and the bases of…

  2. Factory Model and Test Data Descriptions: OPIS Experiments

    Science.gov (United States)

    1990-03-01

    WNO In 0 NW In4W0In0 % In InN .. . .. 0 I~~~~O O O ; InI nnnnn " nIO " ""IanI~~~nnnnnnnnn~~~~~~~~nI nI nI I nI nnn~~~ nI nInI nI I .... .0W10W InVIV 1...0 i i a- a 0 05. N a, 0 in is a a 0 0ce Er aEa.si sa sa -a -a -a -a -a-aaaaaaaaaa0 00 0 0 0 0 0 0 0 0 - - - - ana n nS a ninS n nS i nSnS n nS i nini ...n ni i nini nini n ni i nini n ni i nini n ni i nini n3oi i ni 0 0 0 0 0 0 0. . . ..0 . . . . . . . . . . . . . . ..00 0 0 0 0 0 0. . . . . 0 ~ .f Va

  3. Postoperative urinary retention: evaluation of patients using opioids analgesic Retención urinaria post-operatoria: evaluación de pacientes en tratamiento analgésico con opioides Retenção urinária pós-operatória: avaliação de pacientes em uso de analgesia com opióides

    Directory of Open Access Journals (Sweden)

    Maria do Carmo Barretto de Carvalho Fernandes

    2007-04-01

    ás frecuente en hombres, así como en aquellos pacientes sometidos a analgesia epidural continua. Se sugiere una orientación y vigilancia adecuadas por el equipo de enfermería, haciendo énfasis en el cateterismo vesical intermitente aséptico, durante el transcurso de la retención urinaria, para prevenir complicaciones del tracto urinario.Os objetivos deste estudo foram determinar a incidência de retenção urinária pós-operatória em pacientes que estavam em uso de analgesia com opióides e descrever o método utilizado para esvaziamento vesical. Trata-se de uma série prospectiva e consecutiva de 1.316 pacientes cirúrgicos de 9/1999 a 4/2003. Dos 1.316 pacientes, 594 não usaram cateterismo de demora no pré-operatório. Desses, 128 pacientes apresentaram retenção urinária, com incidência de 22% (128/594. Houve associação estatisticamente significativa entre a ocorrência de retenção urinária e uso da analgesia peridural contínua (p=0,009. Cerca de 69% dos pacientes apresentaram micção espontânea após a realização de apenas um cateterismo. A incidência de retenção urinária encontrada é semelhante à literatura, sendo mais freqüente em homens e naqueles submetidos à analgesia peridural contínua. Sugere-se orientação e vigilância adequada pela equipe de enfermagem, com ênfase no cateterismo vesical intermitente asséptico, na ocorrência de retenção urinária para prevenção de complicações do trato urinário.

  4. Zmiany skórne w przebiegu ostrej białaczki szpikowej – opis przypadku

    Directory of Open Access Journals (Sweden)

    Waldemar Placek

    2011-08-01

    Full Text Available Introduction. Acute myeloid leukaemia is a malignant neoplastic diseaseof white blood cells. About 80% of acute leukaemias in adult arediagnosed as myeloid leukaemias. The presence of transformed cellclones in bone marrow and blood, which originate from very earlystages of myelopoiesis, is characteristic. Beside systemic symptoms(anaemia, thrombocytopenia there are infiltrations in other organs,including skin. Skin lesions are most frequently non-specific (pruritus,skin spots, erythema multiforme, bullous pemphigoid but can be alsospecific (skin tumours. Cases of diffuse xanthomatoses and myeloidsarcoma have also been found in patients with acute myeloidleukaemia. Skin lesions are present more often in lymphocytic thanmyeloid leukaemias. They may precede the disease or its relapse, occurconcomitantly or after systemic symptoms, and sometimes may be ofprognostic value.Objective. To present the case of a patient in whom skin lesions werethe cause of detailed examinations, which revealed acute myeloidleukaemia.Case report. We present a case of a 61-year old patient with purplebrownnodular lesions 1-3 cm in diameter on the face, scalp skin, trunk,limbs and the oral cavity’s mucous membranes with coexistent intensepruritus and generalized lymphadenopathy. The first skin lesionsoccurred three months earlier. During hospitalization in the Departmentof Dermatology the renewal of blasts in the circulatory blood wasobserved and skin biopsy revealed a large amount of mononuclearcells. The patient was directed to the haematological ward, where thediagnosis of acute myeloid leukaemia was established.Conclusions. Our case indicates that the presence of skin lesions andthorough diagnostic procedures may contribute to the diagnosis ofmalignant neoplastic diseases of white blood cells.

  5. Pattern of Paediatric OpI2tba1micAdmissi012s

    African Journals Online (AJOL)

    Onabolu OO. Pattern of Paediatric Ophthalmic Admissions into the Ogun State University ... per cent) and tumours, (15 per cent) were the four main groups of ocular diseases seen. Measles infection was .... right sided abdominal mass. He died ...

  6. Zespół Felty’ego – opis trzech przypadków

    Directory of Open Access Journals (Sweden)

    Anna Raczkiewicz

    2010-02-01

    Full Text Available Zespół Felty’ego (ZF stanowi rzadkie powikłanie reumatoidalnegozapalenia stawów (RZS. Na obraz zespołu składa się współistnienieRZS, neutropenii i (obligatoryjnie splenomegalii. Dla ZFcharakterystyczne są nasilone stawowe i pozastawowe objawyRZS. Przyczynami neutropenii są prawdopodobnie: zahamowaniedojrzewania prekursorów linii granulocytarnej, hamowanie produkcjiczynnika wzrostu kolonii granulocytów (granulocyte colonystimulating factor – G-CSF przez cytokiny, przeciwciała przeciwkogranulocytom oraz sekwestracja granulocytów. Głównymzagrożeniem dla chorych są nawracające infekcje bakteryjne spowodowaneneutropenią, dotyczące najczęściej układu oddechowegoi skóry. Bardzo rzadkim powikłaniem ZF jest zespół nadlepkości.W diagnostyce neutropenii u chorego na RZS należy wziąćpod uwagę toksyczność stosowanych leków, infekcje wirusoweoraz choroby hematologiczne (głównie białaczkę z dużych ziarnistychleukocytów – T-LGL. W leczeniu ZF stosuje się leki modyfikująceprzebieg choroby (disease-modyfing anti-rheumatic drugs–DMARD, niekiedy również czynniki wzrostu kolonii granulocytów(G-CSF i GM-CSF oraz splenektomię. W pracy opisano trzyprzypadki chorych, u których rozpoznano zespół Felty’ego.

  7. Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries

    NARCIS (Netherlands)

    Tsetse, David

    2008-01-01

    Environmental management is usually a complex issue that involves many scientific disciplines and many stakeholders. Environmental management is therefore much helped by schemes that can guide research, reports and discussions in a manner that makes the interconnections between the key elements of p

  8. Analgesia pós-operatória em pacientes pediátricos: estudo comparativo entre anestésico local, opióides e antiinflamatório não esteróide Analgesia pós-operatoria en pacientes pediátricos: estudio comparativo entre anestésico local, opioides y antiinflamatorio no esteróide Postoperative analgesia in pediatric patients: comparative study among local anesthetics, opioids and non-steroidal anti-inflammatory drugs

    Directory of Open Access Journals (Sweden)

    Miriam Seligman Menezes

    2002-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O tratamento da dor pós-operatória em crianças tem merecido atenção especial nas últimas décadas. O propósito deste estudo foi analisar a analgesia pós-operatória de crianças no que se relaciona à qualidade e à duração da analgesia, à confiabilidade dos métodos de avaliação e à incidência de efeitos colaterais decorrentes das diferentes técnicas de analgesia utilizadas. MÉTODO: Participaram do estudo 100 crianças com idades entre 2 e 12 anos alocadas em 5 grupos de 20 crianças cada, que receberam, logo após a indução da anestesia, os seguintes tratamentos de analgesia: grupo B, bupivacaína a 0,25%, com vasoconstritor, 0,5 a 1 ml.kg-1; grupo F, fentanil, 1,5 µg.kg-1; grupo M, morfina, 30 µg.kg-1, grupo S, sufentanil, 0,3 µg.kg-1, todos por via peridural caudal e o grupo D, que recebeu diclofenaco potássico (1 mg.kg-1 por via retal. A dor foi avaliada por 2 métodos distintos: um predominantemente comportamental, objetivo e o outro de auto-avaliação, subjetivo, durante as primeiras 4 horas e a partir deste momento até a 24ª hora. Efeitos colaterais foram observados e tratados. RESULTADOS: Nas primeiras 4 horas os pacientes dos grupos B, F, M e S apresentaram comportamentos semelhantes, com mínimas necessidades de analgesia complementar. Nas 20 horas restantes o maior tempo de analgesia foi o observado no grupo S, não diferindo dos grupos F e M, mas sendo significativamente superior ao tempo dos grupos B e D. Diclofenaco retal não promoveu alívio efetivo da dor. Maior incidência de efeitos colaterais ocorreu no grupo M que não diferiu do grupo S, mas foi significativamente superior aos grupos F, B e D. Houve correlação positiva e significativa entre os escores das 2 escalas de avaliação de dor. CONCLUSÕES: Os opióides espinhais mostraram-se seguros e efetivos na analgesia pós-operatória em crianças, porém quando comparados à bupivacaína não apresentaram diferen

  9. Is Huntington’s disease a neurological or psychiatric disorder? Case report [Choroba Huntingtona zaburzeniem neurologicznym czy psychiatrycznym? Opis przypadku

    OpenAIRE

    Dubas-Ślemp, Halina; Tylec, Aneta; Michałowska-Marmurowska, Halina; Spychalska, Katarzyna

    2012-01-01

    Huntington’s disease is a rare, although commonly known neurodegenerative disease, caused by dynamic point mutation within the IT-15; it is inherited autosomally dominantly. IT-15 mutation includes multiple (36–250) repetitions of trinucleotide sequence (CAG) encoding a glutamine at the amino end of Huntington (mHtt). It is one of the nine polyglutamine diseases (PolyQ), characterized by a CAG repeat. The pathophysiology of Huntington’s disease is associated with dysfunction and loss of neuro...

  10. Erytrodermia łuszczycowa po ogólnym zastosowaniu kortykosteroidów – opis przypadku

    Directory of Open Access Journals (Sweden)

    Joanna Maj

    2011-11-01

    Full Text Available Introduction. Erythroderma (exfoliative dermatitis is an acute, generalizedinflammation of the skin, which affects at least 90% of its surface.It is a life threatening illness in the course of which various types anddegrees of scaling and itching are observed. The main causes of erythrodermaare psoriasis, atopic dermatitis, drug reactions, mycosis fungoidesand pityriasis rubra pilaris. Psoriatic erythroderma is classified as a secondary erythroderma. It may develop spontaneously or moreoften as a result of incorrect treatment.Objective. To present side effects of oral corticosteroids administrationin a patient with psoriasis.Case report. A 36-year-old woman, suffering from psoriasis for over7 years, was admitted to the hospital inMarch 2011 due to exacerbationof skin lesions up to erythroderma after administration of oral corticosteroidtherapy. Three weeks after corticosteroids withdrawal, significantworsening of the disease was observed. On admission she presentedmassiveskin inflammation, scaling and itching. Laboratory testsrevealed increased markers of inflammation. The patient was treatedwith combined immunosuppressive therapy and topical ointments.After 3 weeks, significant regression of skin lesions and normalizationof laboratory tests were observed.Conclusions. Psoriasis is a common cause of erythroderma in adults.Although in Europe the disease affects about 2% of the population andknowledge of its treatment should be common, cases of systemicadministration of corticosteroids in patients with psoriasis in the treatmentof the underlying disease or of the comorbidities are still beingreported.

  11. “Addiction” to phenelzine – case report [„Uzależnienie” od fenelzyny – opis przypadku

    Directory of Open Access Journals (Sweden)

    Antosik-Wójcińska, Anna Z.

    2013-02-01

    Full Text Available The use of non-selective monoamine oxidase inhibitors (IMAO may be associated with the risk of addiction, which is confirmed by case studies published so far. Harmful use of antidepressants in patients with affective disorders and anxiety is not frequent, but due to the fact that in clinical practice can meet with this phenomenon, we present the case of a 30-year-old patient with a history of using phenelzine who presented a combination of symptoms that meet criteria for addiction. The current classification of ICD-10 does not consist the diagnosis of dependence on antidepressants. In this case, the category F55.0: abuse of a substance which does not cause addiction, should be used. In the literature most often mentioned as a possible substances with addictive potential is a group of non-selective MAO, particularly tranylcypromine. The mechanism of non-selective MAO dependence may be associated with the similarity of their chemical structure to amphetamine (both amphetamine and IMAO are derivatives of phenylethylamine, although the mechanism of action is different. Furthermore, it was noted that there is a group of patients in whom treatment with IMAO is associated with greater risk of abuse of these substances. The study contains the characteristics of this group of patients.

  12. Kiła układu nerwowego jako trudny problem w codziennej praktyce klinicznej – opis przypadku

    Directory of Open Access Journals (Sweden)

    Karolina Mędrek

    2011-07-01

    Full Text Available Introduction. Syphilis still represents an important clinical problem.Involvement of the nervous system is one of the major features of latesyphilis, but may also occur in early syphilis.Objective. To present a case of neurosyphilis in relation to the currentproblems of diagnostics and therapy of Treponema pallidum infection.Case report. We present a 31-year-old woman with neurosyphilis. Atthe beginning the patient was treated with erythromycin, and twelvemonths later, because of insufficient decrease of titre of syphilis tests inthe serum, with doxycycline. Despite the second therapy the titres ofsyphilis tests remained high and therefore after another nine monthsthe patient was referred to our department for further diagnostics andtreatment. Because of the long course of the disease, high titres ofsyphilis tests in the serum and abnormalities in neurological examination(hypoaesthesia below the Th8 level, foot clonus and hyporeflexiain lower extremities T. pallidum neuroinfection was suspected andcerebrospinal fluid was collected. The serological examination of cerebrospinalfluid revealed positive treponemal tests (FTA 1 : 10, TPHA++, while VDRL was negative. Based on the whole clinical presentationand laboratory abnormalities, neurosyphilis was diagnosed andtherapy with crystalline penicillin followed by procaine penicillin wasperformed.Conclusions. Neurosyphilis is characterized by rich symptomatologyand its diagnosis based only on clinical manifestation can be very difficult;particularly subtle symptoms may be easily overlooked. Therefore,evaluation of cerebrospinal fluid is necessary in all questionablepatients in order to establish a correct diagnosis.

  13. Comparative analysis of two diffusion methods for radon Rn-222 estimation in atmospheric air by means of gamma-ray spectroscopy and liquid scintillation counting; Analiza porownawcza dwoch metod dyfuzyjnych pomiaru radonu Rn-222 w powietrzu z wykorzystaniem spektrometru promieni gamma i metody cieklej scyntylacji

    Energy Technology Data Exchange (ETDEWEB)

    Gorzkowski, B.; Pachocki, K.; Pensko, J.; Majle, T.; Rozycki, Z. [Panstwowy Zaklad Higieny, Warsaw (Poland)

    1995-12-31

    The comparative measurements of radon Rn-222 concentration in indoor air some buildings and in radon labour chamber have been conducted using two diffusions methods. The results of parallel measurements using radon charcoal detectors and gamma-ray spectroscopy with liquid alpha scintillation counting (Pico-Rad) have been presented. It was concluded that both methods offer the similar measurements possibilities of radon concentrations in the air from about 30 Bq/m{sup 3} to about 600 Bq/m{sup 3} with the real average divergence between both methods of about {+-}11%. (author). 10 refs, 6 figs, 1 tab.

  14. Yas3p, an Opi1 Family Transcription Factor, Regulates Cytochrome P450 Expression in Response to n-Alkanes in Yarrowia lipolytica*

    OpenAIRE

    Hirakawa, Kiyoshi; Kobayashi, Satoshi; Inoue, Takuro; Endoh-Yamagami, Setsu; Fukuda, Ryouichi; Ohta, Akinori

    2009-01-01

    In the alkane-assimilating yeast Yarrowia lipolytica, the expression of ALK1, a gene encoding cytochrome P450 that catalyzes the first step of n-alkane oxidation, is induced by n-alkanes. We previously demonstrated that two basic helix-loop-helix proteins, Yas1p and Yas2p, activate the transcription of ALK1 in an alkane-dependent manner by forming a heterocomplex and binding to alkane-responsive element 1 (ARE1), a cis-acting element in the ALK1 promoter. Here we i...

  15. Męskość i kobiecość w lekturach szkolnych – opis i analiza projektu „Równia Literacka” Fundacji Punkt Widzenia

    Directory of Open Access Journals (Sweden)

    Ewelina Seklecka

    2016-11-01

    Full Text Available "Masculinity and femininity in school readings – project “Równia Literacka” by Punkt Widzenia (“Point of View” Foundation" The basis for the article is a report on the research “Masculinity and femininity in school readings. Analysis of reading material in primary and middle school from the perspective of equality of sexes”. The report was created and published within the project “Równia Literacka”, which was realized by “Point of View” Foundation as part of the program Obywatele dla Demokracji (Citizens for Democracy, financed by EOG Founds. The Report is freely available at: http://www.punktwidzenia.org.pl/wp-content/uploads/2014/09/Raport-M%C4%99sko%C5%9B%C4%87-i-Kobieco%C5%9B%C4%87-w-lekturach-szkolnych1.pdf

  16. Tratamiento con enjuagues de ketamina asociado o no a fentanilo transmucoso en el dolor oncológico orofacial resistente a opiáceos mayores

    National Research Council Canada - National Science Library

    Manuel Cortiñas Saenz; Fernando Espín Galvez; Inmaculada Alférez García; Miren Beatriz Menoyo Alonso; Ana Vega Salvador; Ana García-Carricondo

    2015-01-01

    Objetivo: Evaluar la efectividad de los enjuagues de ketamina asociados o no a fentanilo transmucoso en una serie de diversos dolores orofaciales de etiología neoplásica de difícil control analgésico. Material y métodos...

  17. Evaluación de la eficacia de un programa de psicoterapia multifamiliar con equipo reflexivo en adictos a opiáceos en tratamiento con metadona

    OpenAIRE

    Marcos Sierra, Juan Antonio

    2010-01-01

    Resumen: El presente estudio consta de dos partes: el marco teórico y el estudio empírico. El punto de partida de los aspectos teóricos lo constituye un análisis de la evolución del consumo de drogas en nuestro país, así como las principales repercusiones de este fenómeno. Se describirán en el capítulo uno los avances registrados en las teorías y modelos explicativos de las drogodependencias. En el capítulo dos se revisarán los estudios de evaluación que se han desarrollado, fundamentalmente ...

  18. Trądzik odwrócony leczony operacyjnie innowacyjnymi technikami redukcji powstałych ubytków – opis przypadku

    Directory of Open Access Journals (Sweden)

    Andrzej Bieniek

    2011-11-01

    Full Text Available Introduction. Acne inversa is a recurrent, suppurative disease manifestedby abscesses, fistulas and scarring.Many conservative therapies areusually disappointing, and an early surgical intervention often remainsthe only successful treatment. This condition has a significant impact onthe quality of the patient’s life; therefore there is a need for introductionof effective therapeutic modalities at every stage of the disease.Objective. Presentation of two innovative techniques of wound closureafter surgical excision of the affected skin areas.Case report. A 42-year-old female patient suffering from acne inversa,treated previously with ineffective methods based on a conservativeapproach, was operated on with the use of tumescent infiltration anaesthesiaand our own surgical techniques such as the “star-like” and“pubic flaps” techniques.Conclusions. Presented data show unequivocally that our own methodsof surgical wound closure are highly effective and that a patientwith acne inversa can tolerate it well. We encourage the use of thesetechniques, but choosing the best option requires an individualapproach.

  19. Tratamiento con enjuagues de ketamina asociado o no a fentanilo transmucoso en el dolor oncológico orofacial resistente a opiáceos mayores

    Directory of Open Access Journals (Sweden)

    Manuel Cortiñas Saenz

    2015-04-01

    Conclusión: Los enjuagues de ketamina son una opción eficaz para el tratamiento del dolor orofacial secundario al cáncer. En caso de presencia de episodios de dolor irruptivo recurrente, la asociación de ketamina en enjuague bucal y citrato de fentanilo oral transmucoso puede ser una opción viable en dolor refractario a otros tratamientos.

  20. Endometrioza o potrójnej lokalizacji: w przegrodzie odbytniczo-pochwowej, w bliźnie po cięciu cesarskim oraz w jajniku – opis przypadku

    Directory of Open Access Journals (Sweden)

    Andrzej Skręt

    2011-10-01

    Full Text Available The authors discuss the symptoms, pathogenesis and treatment of endometriosis of multiple localization:in the recto-vaginal septum, in a post-caesarean scar and in the ovary. In the available literature we found nodata on the prevalence of endometriosis in triple localisation. The authors discuss symptoms, pathogenesis andtreatment of endometriosis concerning the described localisation.

  1. Opiáceo intratecal na dor crônica não neoplásica: alívio e qualidade de vida Intrathecal opioids for treatment of intractable non-malignant pain

    Directory of Open Access Journals (Sweden)

    CIBELE ANDRUCIOLI DE MATTOS PIMENTA

    1998-09-01

    Full Text Available O uso de agentes morfínicos para o controle da dor crônica não relacionada a câncer é controverso. Este estudo aferiu o alívio da dor e as mudanças nas atividades de 11 doentes com dor crônica não associada ao câncer, tratados pela infusão intratecal de fármacos morfínicos através de bombas implantáveis. A dor era neuropática em 5 doentes e miofascial em 6. A duração média da queixa álgica foi 5,3 anos. A média da intensidade da dor antes da infusão foi 8,6. Sete doentes apresentavam dor durante 6 ou mais horas por dia. Após o tratamento, a média de intensidade da dor reduziu-se para 3,9. Somente 1 doente manteve dor com duração superior a 6 horas. O tratamento melhorou o desempenho de 36,36% dos aspectos funcionais avaliados. O tempo médio de tratamento foi 19,6 meses. A infusão crônica de agentes morfínicos por via intratecal proporcionou alívio da dor, mas não melhorou a funcionalidade com a mesma magnitude.The use of opioids for treatment of non-malignant pain is controversial. The evaluation of pain relief and of the quality of life of 11 severely incapacitated chronic non-cancer pain patients treated with long term intrathecal infusion of opioids trought implantable pumps was performed. The mean duration of pain complaints was 5.3 years. The mean pain intensity was 8.6. In 7 patients, pain episodes lasted at least 6 hours daily. The mean duration of the therapy was 19.6 months. After the treatment the mean pain score became 3.9. In only 1 patient, the duration of pain episodes was still longer than 6 hours. Quality of life improved in 36.36% of the cases. The long term spinal opioids through implantable pumps for non-malignant pains results in pain relief but not necessarily improves the quality of life.

  2. Analgesia peridural para o trabalho de parto e para o parto: efeitos da adição de um opióide Effects of the association of an opioid with epidural analgesia for labor and delivery

    Directory of Open Access Journals (Sweden)

    José Guilherme Cecatti

    1998-07-01

    Full Text Available O objetivo deste estudo foi avaliar a eficácia e segurança da associação bupivacaína com sufentanil para a analgesia no trabalho de parto e do parto por meio de um bloqueio peridural contínuo. Realizou-se um ensaio clínico duplo-cego, prospectivo e aleatório, incluindo sessenta mulheres nulíparas da Maternidade do CAISM/UNICAMP. No momento da analgesia, as mulheres foram aleatoriamente alocadas em dois grupos: BS, recebendo 12,5 mg de bupivacaína com adrenalina mais 30 µg de sufentanil e BP, recebendo 12,5 mg de bupivacaína com adrenalina mais placebo. Foram avaliados os parâmetros relativos à qualidade e duração da analgesia, duração do trabalho de parto e também possíveis efeitos sobre o recém-nascido. Os resultados mostraram a superioridade da adição do sufentanil sobre o grau de analgesia durante o tempo de ação da primeira dose de anestésico local. Não houve aumento na duração do trabalho de parto depois do início da analgesia quando se compararam ambos os grupos, nem qualquer diferença quanto à via de parto. Não houve também diferenças entre os grupos com relação à avaliação dos recém-nascidos. Conclui-se que a associação de 30 µg de sufentanil à primeira dose de bupivacaína é segura e eficaz, melhorando a qualidade da analgesia, sua duração e não afetando a progressão do trabalho de parto e o resultado neonatal.The purpose of the present study was to evaluate the efficacy and safety of the association bupivacaine with sufentanil for labor and delivery analgesia through a continuous epidural blockade, for both mother and the neonate. A randomized double blind prospective clinical trial was performed including sixty nulliparous women at the Maternity of CAISM/UNICAMP. When requesting analgesia, the women were randomly allocated to two groups: BS, receiving 12.5 mg of bupivacaine with adrenaline plus 30 µg of sufentanil and BP, receiving 12.5 mg of bupivacaine with adrenaline plus placebo. The parameters concerning the quality and duration of analgesia, duration of labor, and also possible effects on the neonate were evaluated. The results showed the superiority of the addition of sufentanil regarding the degree of analgesia during the time of action of the first dose of the local anesthetic. There was no increase in the duration of labor after the onset of analgesia when comparing both groups, nor any difference in the route of delivery. Concerning neonate evaluation, there were no differences between the two groups. It is concluded that the association of 30 µg of sufentanil with the first dose of bupivacaine is safe and efficacious. It improved the quality of analgesia, increased its duration, and did not affect the progress of labor and neonatal outcome.

  3. 积极提升执政党的网络舆情引导能力%Actively ImproviNg the RuliNg Party’s Ability to Guide ONliNe Public OpiNioN

    Institute of Scientific and Technical Information of China (English)

    薛小荣; 陆旸

    2015-01-01

    The ability to guide online public opinion refers to the ruling party’s ability to effectively lead the de-velopment situation of internet public opinion. Efforts should be made in four aspects to strengthen this ability. First,master the social causes of public opinion,and proactively carry out psychological counseling. Second, gather all forces and involve the whole party in public opinion governance. Third,persist in the principle of infor-mation openness,and provide positive guidance timely. Fourth,strengthen the principle of govern internet accord-ing to law,and work hard to normalize online behavior.%网络舆情引导能力是指执政党能够对网络舆情发展态势进行有效引导的能力。应该从四个方面着手加强能力建设:一是掌握舆情社会成因,主动开展心理疏导;二是整合舆情治理力量,形成全党参与格局;三是坚持信息公开原则,及时正面加以引导;四是加强依法治网原则,着力规范网络行为。

  4. The use of RHLB battery for the evaluation of the lingual and social skills among psychiatric patients – case study [Zastosowanie baterii RHLB do oceny funkcji językowychi komunikacyjnych pacjentów psychiatrycznych – opis przypadku

    Directory of Open Access Journals (Sweden)

    Gałecki, Piotr

    2012-12-01

    Full Text Available Prosody plays an important role in the process of verbal communication, complementing and emphasising the linguistic and emotional aspects of language. Disturbances of speech prosody are rarely recognised, although aprosodia occurs frequently in patients with schizophrenia. Prosodic disturbance of speech can significantly impair verbal communication and social functioning of patients with schizophrenia. Right-hemisphere is connected with emotional prosody deficits and left-hemisphere with linguistic prosody. The aim of the study is to describe.The Right Hemisphere Language Battery by Karen L. Bryan in the examination of patients with schizophrenia.

  5. Simulation of Rn-222 decay products concentration deposited on a filter. Description of radon1.pas computer program; Symulacja koncentracji produktow rozpadu Rn-222 osadzanych na filtrze. Opis programu komputerowego radon1.pas

    Energy Technology Data Exchange (ETDEWEB)

    Machaj, B. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1996-12-31

    A computer program allowing simulation of activity distribution of {sup 222}Rn short lived decay products deposited on a filter against time is presented, for any radiation equilibrium degree of the decay products. Deposition of the decay products is simulated by summing discrete samples every 1/10 min in the sampling time from 1 to 10 min. The concentration (activity) of the decay products is computed in one minute intervals in the range 1 - 100 min. The alpha concentration and the total activity of {sup 218}Po + {sup 214}Po produced are computed in the range 1 to 100 min as well. (author). 10 refs, 4 figs.

  6. Synthesis and Crystal Structure of Dinuclear Copper Complex [Cu(CH2O(C6H4)N=C(C6H4)O)(Py)]2

    Institute of Scientific and Technical Information of China (English)

    牛德仲; 沐来龙; 路再生; 王玉成; 陈久桐

    2002-01-01

    The complex [Cu2L2(Py)2] (H2L=2-aminobenzoic alcohol condensation salicylaldehyde) was obtained. A single-crystal X-ray study shows that the complex is a binuclear compound (Cu2C38H32N4O4). The coordination geometry about each copper atom is best described as a distorted square pyramid. The compound [Cu2L2(Py)2] belongs to monoclinic system with space group P21, lattice constants: a = 10.3881(1), b = 17.9724(1), c = 17.5800(2) A, β =90.4880(1)°, V= 3282.05(5) A3, Z= 4, Mr =735.75, Dc=1.489 g/cm3, μ= 1.344mm-1, F(000) = 1512, R=0.0519, wR=0.1092 for 6725 reflections with I >2σ(I). The distances between Cu(II) and O atoms are range from 1.898(6) to1.976(5)A, between Cu(II) and N atoms are range from 1.990(6) to 2.369(7)A. The Cu(1)-Cu(2) bond length is 3.024(4) A.

  7. Schizophrenia-like psychotic symptoms in a patient with confirmed Huntington’s disease: A case report [Objawy psychotyczne sugerujące schizofrenię u pacjenta z potwierdzonym rozpoznaniem choroby Huntingtona – opis przypadku

    Directory of Open Access Journals (Sweden)

    Grabski, Bartosz

    2012-08-01

    Full Text Available Aim. The aim of this study is to discuss diagnostic and therapeutic challenges in a patient with a mutation in the gene responsible for the development of Huntington’s disease (HD who presented schizophrenia-like psychotic symptoms. Method. A case report. Results. A 35-year old man with genetically-confirmed HD who developed significant behavioural changes that occurred many years prior to the outbreak of choreic movements. There was a close temporal relationship between an onset of discrete involuntary movements and schizophrenia-like psychotic symptoms (delusions of persecution, reference and bodily change, as well as auditory pseudohallucinations of threatening and commanding voices. At admission (subsequently to a suicidal attempt he was ambivalent, ambitendent and – periodically – agitated. Pharmacotherapeutic regime of olanzapine (20 mg qd and amisulpride (400 mg qd led to a gradual improvement of the patient’s mental status. Conclusions. HD should always be included in the differential diagnosis of psychotic disorders. Patients with HD can exhibit various psychopathological symptoms (including psychotic ones prior to the outbreak of movement symptoms. Both neurologists and psychiatrists should take part in the therapeutic process. Atypical antipsychotics seem to be effective in the discussed group of patients (although the evidence body consists mainly of scarce, low-quality data.

  8. On Student Pilots' English Listening and Speaking Teaching in Perspective of OPI in ICAO English Test%从ICAO英语OPI测试看飞行学生英语听说课教学

    Institute of Scientific and Technical Information of China (English)

    刘武

    2013-01-01

    根据近几年飞行学生ICAO英语OPI测试中反映出的问题,从两个方面反思了基础英语阶段飞行学生英语听说课教学的目标、内容与原则,以及教学实践中的问题与对策.

  9. Las implicaciones de la nueva Ley de la Ciencia en la difusión de los resultados de proyectos científicos en España: Jornada de OPIS y Open Access

    OpenAIRE

    Bernal, Isabel

    2012-01-01

    El 3 de diciembre pasado entró en vigor la nueva Ley de la Ciencia, la Tecnología y la Innovación. Entre las novedades de la Ley cabe destacar el artículo 37 ya que prevé la difusión a través de repositorios de las publicaciones resultantes de los proyectos de investigación financiados por los Presupuestos Generales del Estado. Literalmente, “el personal de investigación cuya actividad investigadora esté financiada mayoritariamente con fondos de los Presupuestos Generales del Estado hará públ...

  10. Wina bez kary – o bezkarności manipulatora

    OpenAIRE

    Łukowski, Piotr

    2015-01-01

    Wielu wybitnych psychologów, takich jak Philip Zimbardo czy Simon Baron-Cohen, stawia fundamentalne pytanie: Jak dobrzy ludzie mogą skłaniać się do zła? Odpowiedź na nie powinna być przedmiotem zainteresowania i stanowić ważny temat również dla prawników. Oczywiście czasami istnieją takie sytuacje, kiedy tzw. dobrzy ludzie stają się sprawcami przestępstwa. Niektóre z tych sytuacji wcale nie są przypadkowe, lecz kreowane przez kogoś, kto dobrze zna metody manipulowania innymi ludźmi. Wówczas m...

  11. Stepwise modification of titanium alkoxy chloride compounds by pyridine carbinol.

    Science.gov (United States)

    Boyle, Timothy J; Ottley, Leigh Anna M; Rodriguez, Mark A; Sewell, Robin M; Alam, Todd M; McIntyre, Sarah K

    2008-11-17

    The stepwise modifications of stoichiometric mixtures of titanium chloride (TiCl 4) and titanium iso-propoxide (Ti(OPr (i)) 4) by 2-pyridine methanol (H-OPy) led to the isolation of a systematically varied, novel family of compounds. The 3:1 reaction mixture of Ti(OPr (i)) 4:TiCl 4 yielded [Cl(OPr (i)) 2Ti(mu-OPr (i))] 2 ( 1). Modification of 1 with 1 and 2 equiv of H-OPy produced [Cl(OPr (i)) 2Ti(mu c-OPy)] 2 ( 2, where mu c = chelating bridge) and "(OPy) 2TiCl(OPr (i))" ( 3, not crystallographically characterized), respectively. Altering the Ti(OPr (i)) 4 to TiCl 4 stoichiometry to 1:1 led to isolation and identification of another dimeric species [Cl 2(OPr (i))Ti(mu-OPr (i))] 2 ( 4). Upon modification with 1 equiv of H-OPy, [Cl 2(OPr (i))Ti(mu c-OPy)] 2 ( 5) was isolated from toluene and (OPy)TiCl 2(OPr (i))(py) ( 6) from py. An additional equivalent of H-OPy led to the monomeric species (OPy) 2TiCl 2 ( 7). Because of the low solubility and similarity in constructs of these compounds, additional analytical data, such as the beryllium dome or BeD-XRD powder analyses, were used to verify the bulk samples, which were found to be in agreement with the single crystal structures.

  12. A novel Interactive Health Communication Application (IHCA) for parents of children with long-term conditions: Development, implementation and feasibility assessment.

    Science.gov (United States)

    Swallow, Veronica; Carolan, Ian; Smith, Trish; Webb, Nicholas J A; Knafl, Kathleen; Santacroce, Sheila; Campbell, Malcolm; Harper-Jones, Melanie; Hanif, Noreen; Hall, Andrew

    2016-01-01

    Few evidence-based, on-line resources exist to support home-based care of childhood long-term conditions. In a feasibility study, children with stages 3, 4, or 5 chronic kidney disease, parents and professionals collaboratively developed a novel Online Parent Information and Support (OPIS) application. Parents were randomized to an intervention arm with access to OPIS or a control arm without access. OPIS usage was assessed using Google Analytics. Parents in the intervention arm completed the Suitability Assessment of Materials (SAM) and User Interface Satisfaction (USE) questionnaires and participated in qualitative interviews. Twenty parents accessed OPIS with a mean of 23.3 (SD 20.8, range 2-64) visits per user. Responses from the SAM and USE questionnaires were positive, most respondents rating OPIS highly and finding it easy to use. Qualitative suggestions include refinement of OPIS components, enabling personalization of OPIS functionalities and proactive endorsements of OPIS by professionals. Implementation of OPIS into standard practice is feasible in the centre where it was developed. Suggested developments will augment reported strengths to inform ongoing testing in the wider UK network of units. Our design and methods are transferrable to developing and evaluating web-applications to support home-based clinical care-giving for other long-term conditions.

  13. Münchausen syndrome by proxy in a forensic psychiatric evaluation – the description of a case and ethical controversy [Przeniesiony zespół Münchausena w opinii sądowo-psychiatrycznej – opis przypadku i kontrowersje etyczne

    Directory of Open Access Journals (Sweden)

    Heitzman, Janusz

    2012-08-01

    Full Text Available Aim. Presentation of the difficulties in diagnosing Münchausen syndrome by proxy. Method. Comparison of four different conclusions in forensic psychiatric opinions issued in one case, due to the need of answering to the questions of the court, in what periods and why was the deterioration of the child’s health, in connection with an allegation that the mother has acted to his detriment. In the first medical-legal opinion the treating physician, while being the head of the ward and the person informing the police of the action against a child by the mother, recognised Münchausen syndrome by proxy. The second opinion was delivered by a psychologist, who stated that the mother distinguished the introspective attitude characterised by excessive, exaggerated accuracy, thoroughness, and did not give a unambiguous answer to the questions of the court. In the third opinion the experts accepted that the functioning of the subject does not create a threat to life and health of the child. The fourth opinion developed by the authors of this paper noted that in the analysed medical records of the childs’ hospitalisation, no arguments were found to recognise Münchausen syndrome by proxy. Results. In the conducted extended ambulant study of the subject and the analysis of the medical documentation of the 31 hospitalisations of the child showed that the improvement of the child’s health was not associated in exclusion of pushing aside the mother from the child, but was the result of the consistency of the therapeutic treatment team, the continuation and the modification of the treatment. Conclusions. In appointing the expert, the art. 196 of the Code of Criminal Procedure should be considered, which states that the expert should not be the treating doctor, because his opinion loses value impartiality. Diagnosis of Münchausen Syndrome by proxy itself stirs up numerous controversies..

  14. Autoaggressive behaviour with patients suffering from type 1 diabetes treated at the Clinic for Psychiatry and Psychotherapy Developmental Age – description of cases [Zachowania autoagresywne u pacjentek chorujących na cukrzycę typu 1 leczonych na oddziale klinicznym psychiatrii i psychoterapii wieku rozwojowego – opis przypadków

    Directory of Open Access Journals (Sweden)

    Hacia, Sabina

    2013-10-01

    Full Text Available Aim. The aim of this study was to observe autoagressive behaviour with patients suffering from type 1 diabetes hospitalized in The Child Psychiatry Department of The Paediatric Centre in Sosnowiec.Method. Analysis of clinical cases, medical documentation and literature. Results. Patients suffered from type 1 diabetes. On account of mental disorders they required treatment in a psychiatric ward. In the course of their hospitalization the appearance of various autoagressive behaviour were observed– the sick deliberately gave a dose of insulin improperly, apply an inadequate diet, and also self-mutilated themselves.Conclusions. Described patients by their own illness (type 1 diabetes in a self-destructive way coped with negative emotions. Autoagressive behaviour were their way of coping with stress, communicating experienced problems to others, they also helped in reducing inner tension. Through autoagression patients express anger, guilt, shame, loneliness, inner emptiness, a lack of confidence or humiliation. The period of adolescence, female gender and the presenceof chronic disease are the factors that could intensify the difficulties described.

  15. Confecção de um modelo experimental in vitro do espaço subaracnóide eqüino para teste de opióides hiperbáricos Making of an in vitro experimental model of equine subarachnoid space to test hyperbaric opioids

    Directory of Open Access Journals (Sweden)

    Alexandre da Silva Polydoro

    2008-04-01

    Full Text Available Com o objetivo de avaliar as características de distribuição de agentes hiperbáricos no líquido cérebro-espinhal (LCE eqüino, é apresentado um modelo in vitro do espaço subaracnóide confeccionado em policloreto de vinila (PVC transparente, no qual se adaptou um cateter para a infusão contínua de glicose a 10%, morfina hiperbárica, buprenorfina hiperbárica e metadona hiperbárica marcadas com azul de metileno para permitir a visualização da distribuição destas substâncias no LCE. Avaliaram-se a distância alcançada pelos diferentes agentes minuto a minuto e a forma de distribuição dos mesmos. Todas as substâncias testadas mostraram comportamento de distribuição vertical a partir da extremidade do cateter, quando se deu o início da migração cranial no LCE, sendo que o avanço máximo registrado foi aos 15 minutos após o término da infusão, com migração de 15cm para glicose a 10%, 13cm para a morfina hiperbárica, 18cm para a buprenorfina hiperbárica e 17cm para a metadona hiperbárica. O modelo proposto mostrou-se eficiente para a avaliação do comportamento físico dos agentes hiperbáricos no interior do espaço subaracnóide, oferecendo a possibilidade de teste de substâncias a serem utilizadas pela via subaracnóide de cavalos.The aim of this study was to evaluate the distribution characteristics of hyperbaric solutions in equine cerebrospinal fluid (CSF, in an in vitro model of the subarachnoid space. The model was made with transparent PVC in which a catheter was adapted to infuse 10% glucose, 10% hyperbaric morphine, hyperbaric buprenorphine, and hyperbaric methadone, dyed with methilene blue in order to visualize the solutions distribution in the CSF. The distance in cm reached by the different agents every minute as well as the pattern of distribution were evaluated. All tested solutions distributed itself in a forward and vertically pattern from the tip of the catheter. Maximum distance reached after 15 minutes were 15cm for 10% glucose, 13cm for hyperbaric morphine, 18cm for hyperbaric buprenorphine, and 17cm for hyperbaric methadone. The proposed model was efficient to evaluate the distribution pattern of hyperbaric solutions in equine CSF, offering a new possibility to physically test the administration of solutions in the equine subarachnoid space.

  16. Autoaggressive behaviour with patients suffering from type 1 diabetes treated at the Clinic for Psychiatry and Psychotherapy Developmental Age – description of cases [Zachowania autoagresywne u pacjentek chorujących na cukrzycę typu 1 leczonych na oddziale klinicznym psychiatrii i psychoterapii wieku rozwojowego – opis przypadków

    OpenAIRE

    Hacia, Sabina; Cichoń, Lena; Nowak, Marta; Fuchs, Anna; Jarosz-Chobot, Przemysława; Janas-Kozik, Małgorzata

    2013-01-01

    Aim. The aim of this study was to observe autoagressive behaviour with patients suffering from type 1 diabetes hospitalized in The Child Psychiatry Department of The Paediatric Centre in Sosnowiec.Method. Analysis of clinical cases, medical documentation and literature. Results. Patients suffered from type 1 diabetes. On account of mental disorders they required treatment in a psychiatric ward. In the course of their hospitalization the appearance of various autoagressive behaviour were obser...

  17. Taking Charge: Teacher Candidates' Preparation for the Oral Proficiency Interview

    Science.gov (United States)

    Sullivan, JoAnn Hammadou

    2011-01-01

    Within second language education, concern over teachers' content knowledge has typically manifested itself as concern over the teacher's target language proficiency. In increasing numbers, teacher preparation programs are turning to ACTFL's Oral Proficiency Interview (OPI) for measurement of this proficiency and using OPI ratings as high-stakes…

  18. The Impact of the Oral Proficiency Interview on One Foreign Language Teacher Education Program

    Science.gov (United States)

    Kissau, Scott

    2014-01-01

    The Oral Proficiency Interview (OPI) has been increasingly used in academia. However, while multiple studies have documented the growth in OPI implementation across the United States and the proficiency rates of its completers, few have focused specifically on foreign language teacher candidates, and even fewer have investigated the impact that…

  19. Merjenje in vzdrževanje pH vrednosti bazenske vode v Termah Čatež

    OpenAIRE

    JUREČIČ, ALEŠ

    2015-01-01

    Diplomsko delo opisuje merjenje pH vrednosti bazenske vode, delovanje referenčne, indikatorske, kombinirane elektrode, njihove lasnosti in uporabo v bazenski industriji. V poglavju 2 opišem pomen, zgodovino pH-ja, delovanje enostavnega pH metra in steklene elektrode, ter njuno kalibracijo. V naslednjem poglavju opišem bazen in sisteme bazena. Vsak sistem bazena opišem glede na njegove naloge in namen. V četrtem poglavju je predstavljena programska in strojna oprema, ki je uporabljena v na...

  20. Multispectral high-resolution hologram generation using orthographic projection images

    Science.gov (United States)

    Muniraj, I.; Guo, C.; Sheridan, J. T.

    2016-08-01

    We present a new method of synthesizing a digital hologram of three-dimensional (3D) real-world objects from multiple orthographic projection images (OPI). A high-resolution multiple perspectives of 3D objects (i.e., two dimensional elemental image array) are captured under incoherent white light using synthetic aperture integral imaging (SAII) technique and their OPIs are obtained respectively. The reference beam is then multiplied with the corresponding OPI and integrated to form a Fourier hologram. Eventually, a modified phase retrieval algorithm (GS/HIO) is applied to reconstruct the hologram. The principle is validated experimentally and the results support the feasibility of the proposed method.

  1. Drug: D02878 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available , postoperative ileus, idiopathic constipation, and irritable bowel syndrome [peripherally restricted mu opi...0.2573 460.5631 D02878.gif Treatment of opioid-induced bowel dysfunction, opioid-induced nausea and vomiting

  2. Disease: H01104 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ination of lymphatic filariasis: do we have the drugs to complete the job? Curr Opi...rica--treatment challenges and prospects. Clin Microbiol Infect 17:977-85 (2011) PMID:20847694 (description) Bockarie MJ, Deb RM Elim

  3. Overexpression of citrus polygalacturonase-inhibiting protein in citrus black rot pathogen Alternaria citri.

    Science.gov (United States)

    Katoh, Hiroshi; Nalumpang, Sarunya; Yamamoto, Hiroyuki; Akimitsu, Kazuya

    2007-05-01

    The rough lemon (Citrus jambhiri) gene encoding polygalacturonase-inhibiting protein (RlemPGIPA) was overexpressed in the pathogenic fungus Alternaria citri. The overexpression mutant AcOPI6 retained the ability to utilize pectin as a sole carbon source, and the overexpression of polygalacturonase-inhibiting protein did not have any effect on the growth of AcOPI6 in potato dextrose and pectin medium. The pathogenicity of AcOPI6 to cause a black rot symptom in citrus fruits was also unchanged. Polygalacturonase-inhibiting protein was secreted together with endopolygalacturonase into culture filtrates of AcOPI6, and oligogalacturonides were digested from polygalacturonic acid by both proteins in the culture filtrates. The reaction mixture containing oligogalacturonides possessed activity for induction of defense-related gene, RlemLOX, in rough lemon leaves.

  4. Síntese, caracterização e estudo das propriedades magnéticas de um polímero de coordenação contendo cobalto(II e cobre(II

    Directory of Open Access Journals (Sweden)

    Tamyris T. da Cunha

    2012-01-01

    Full Text Available This work describes the synthesis and characterization of two new compounds with ligand opy (N-(2-pyridyloxamate: the copper(II precursor [Me4N]2[Cu(opy2].5H2O and CoII CuII coordination polymer {[CoCu(opy2]}n×4nH2O. This latter compound was obtained by reaction of [Me4N]2[Cu(opy2].5H2O and CoCl2.6H2O in water. The heterobimetallic CoII CuII chain was characterized by elemental analysis, IR spectroscopy, thermogravimetry and magnetic measurements. Magnetic characterization revealed typical behavior of one-dimensional (1D ferrimagnetic chain as shown in the curves of temperature (T dependence of magnetic susceptibility (χM, in the form of χMT versus T, and dependence of magnetization (M with applied field (H.

  5. Sufentanil subaracnóideo associado à bupivacaína hiperbárica para analgesia de parto: É possível reduzir a dose do opióide? Sufentanil subaracnóideo asociado a la bupivacaína hiperbárica para analgesia de parto: Es posible reducir la dosis del opioide? Spinal sufentanil associated to hyperbaric bupivacaine: Is it possible to decrease opioid dose?

    Directory of Open Access Journals (Sweden)

    Eduardo Tsuyoshi Yamaguchi

    2004-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A adição de bupivacaína isobárica a doses menores de sufentanil por via subaracnóidea promove analgesia de qualidade satisfatória, com menor incidência de efeitos colaterais. O objetivo do estudo foi avaliar a qualidade da analgesia e a incidência de efeitos colaterais de doses reduzidas de sufentanil subaracnóideo associados à bupivacaína hiperbárica em analgesia de parto. MÉTODO: Foram estudadas prospectivamente 69 gestantes de termo em trabalho de parto. As gestantes foram aleatoriamente divididas em três grupos que receberam, no espaço subaracnóideo, a combinação de 2,5 mg de bupivacaína hiperbárica e 1 ml de solução fisiológica (Grupo Controle; 2,5 mg de bupivacaína hiperbárica e 2,5 µg de sufentanil (Grupo S2,5 ou 2,5 mg de bupivacaína hiperbárica e 5 µg de sufentanil (Grupo S5. A dor, de acordo com a escala analógico visual (EAV de dor e a incidência de efeitos colaterais foram avaliadas a cada 5 minutos nos primeiros quinze minutos e a seguir a cada 15 minutos até o nascimento. O estudo terminava com o nascimento, ou quando a paciente solicitava medicação analgésica de resgate (EAV > 3 cm. RESULTADOS: Os grupos S2,5 e S5 apresentaram maior duração de analgesia (67,2 ± 38,6 e 78,9 ± 38,7 minutos, respectivamente e maior porcentagem de pacientes com analgesia efetiva (100% e 95,6%, respectivamente que o grupo Controle, no qual a duração média de analgesia foi de 35,9 ± 21,6 minutos (p JUSTIFICATIVA Y OBJETIVOS: La adición de bupivacaína isobárica a dosis menores de sufentanil por vía subaracnóidea promueve analgesia de cualidad satisfactoria, con menor incidencia de efectos colaterales. El objetivo del estudio fue evaluar la calidad de la analgesia y la incidencia de efectos colaterales de dosis reducidas de sufentanil subaracnóideo asociados a bupivacaína hiperbárica en analgesia de parto. MÉTODO: Fueron estudiadas prospectivamente 69 embarazadas de término en trabajo de parto. Las embarazadas fueron aleatoriamente divididas en tres grupos que recibieron, en el espacio subaracnóideo, la combinación de 2,5 mg de bupivacaína hiperbárica y 1 mL de solución fisiológica (Grupo Control; 2,5 mg de bupivacaína hiperbárica y 2,5 µg de sufentanil (Grupo S2,5 o 2,5 mg de bupivacaína hiperbárica y 5 µg de sufentanil (Grupo S5. El dolor, de acuerdo con la escala analógico visual (EAV de dolor y la incidencia de efectos colaterales fueron evaluadas a cada 5 minutos en los primeros quince minutos y a seguir a cada 15 minutos hasta el nacimiento. El estudio terminaba con el nacimiento, o cuando la paciente solicitaba medicación analgésica de rescate (EAV > 3 cm. RESULTADOS: Los grupos S2,5 y S5 presentaron mayor duración de analgesia (67,2 ± 38,6 y 78,9 ± 38,7 minutos, respectivamente y mayor porcentaje de pacientes con analgesia efectiva (100% y 95,6%, respectivamente que el grupo Control, en el cual la duración media de analgesia fue de 35,9 ± 21,6 minutos (p BACKGROUND AND OBJECTIVES: The association of isobaric bupivacaine to lower spinal sufentanil dose provides satisfactory analgesia and lower incidence of side effects. This study aimed at evaluating quality of analgesia and incidence of side effects of decreased spinal sufentanil doses associated to hyperbaric bupivacaine for labor analgesia. METHODS: Participated in this study 69 healthy term pregnant patients in active labor. Patients were randomly allocated in three groups receiving spinal combination of 2.5 mg hyperbaric bupivacaine and 1 mL saline solution (Control Group; 2.5 mg hyperbaric bupivacaine and 2.5 µg sufentanil (S2.5 Group or 2.5 mg hyperbaric bupivacaine and 5 µg sufentanil (S5 Group. Pain, using a visual analogue scale (VAS, and side effects were evaluated at 5-minute intervals for the first 15 minutes and then at 15-minute interval until delivery. Study would end with delivery or when patient requested rescue analgesia (VAS > 3 cm. RESULTS: Groups S2.5 and S5 presented longer analgesia duration (67.2 ± 38.6 and 78.9 ± 38.7 minutes, respectively and a larger number of patients with effective analgesia (100% and 95.6%, respectively as compared to Control group where mean analgesia duration was 35.9 ± 21.6 minutes (p < 0.05 with 69.6% of patients with effective analgesia (p < 0.05. CONCLUSIONS: The association of sufentanil to hyperbaric bupivacaine improves quality and prolongs analgesia duration. When associated to 2.5 mg hyperbaric bupivacaine, there is no benefit in administering more than 2.5 µg of sufentanil for labor pain relief.

  6. SENCE V OPENGL

    OpenAIRE

    Kohek, Štefan

    2010-01-01

    V diplomskem delu opišemo metode za ustvarjanje in prikaz senc objektov z uporabo grafične knjižnice OpenGL. Največ poudarka je na projekcijski metodi. Praktični del zajema izdelavo programa, ki omogoča prikaz senc objektov LWO z uporabo projekcijske metode in z uporabo tekstur senc. Na koncu opišemo demonstracijski program.

  7. SPLETNI PORTAL ZA SODNEGA IZVRŠITELJA

    OpenAIRE

    Kraljič, Boštjan

    2011-01-01

    Diplomska naloga predstavlja odprtokodno programsko orodje Joomla, za izdelavo in osveževanje spletnega portala. Xampp paket vsebuje vse potrebne komponente in module za izdelavo spletne strani in temelji na odprtokodni osnovi, spletni strežnik Apache, podatkovna baza Mysql in skriptni jezik PHP. Cilj diplomske naloge je izdelava, upravljanje in raba spletne strani sodnega izvršitelja. V uvodnem delu je opis postavitve spletnega portala CMS Joomla in opis uporabljenih orodij. V osred...

  8. Donor risk index and organ patient index as predictors of graft survival after liver transplantation.

    Science.gov (United States)

    Avolio, A W; Siciliano, M; Barbarino, R; Nure, E; Annicchiarico, B E; Gasbarrini, A; Agnes, S; Castagneto, M

    2008-01-01

    In liver transplantation the identification of risk factors and the risk quantification for each single case represent a field of great interest. There are donor-related and recipient-related risk factors. Donor risk index (DRI) was retrospectively calculated in 223 liver transplant cases. We did not include patients with preoperative diagnosis of hepatocarcinoma and retransplants. The cases were stratified into two classes according to the DRI (low risk, DRIor= 1.7). A new index, namely the organ patient index (OPI) was calculated adding the Model for End-stage Liver Disease (MELD) score to the DRI. Patients were stratified into two classes according to the OPI (low risk, OPI 2.85). The cases with low DRI (n=144) showed better survival than the cases with high DRI (n=82; P< .02). The cases with low OPI (n=173) showed better survival than cases with high OPI (n=50; P< .01). The OPI predicted outcomes better than DRI, increasing the gap in the long-term graft survival between the low- and the high-risk class. The inclusion of the MELD in the new index allowed better prediction of graft survival.

  9. The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device.

    Science.gov (United States)

    Blake, E; Campbell, S; Allen, J; Mathew, J; Helliwell, P; Curnow, A

    2012-12-01

    Topical protoporphyrin (PpIX)-induced photodynamic therapy (PDT) relies on the penetration of the prodrug into the skin lesion and subsequent accumulation of the photosensitizer. Methyl aminolevulinate (MAL)-PDT is an established treatment for thinner and superficial non-melanoma skin cancers (NMSCs) but for the treatment of the thicker nodular basal cell carcinoma (nBCC) enhanced penetration of the prodrug is required. This study employed a new higher pressure, oxygen pressure injection (OPI) device, at the time of Metvix® application with a view to enhancing the penetration of MAL into the tumors. Each patient had Metvix® applied to a single nBCC followed by application of a higher pressure OPI device. Following different time intervals (0, 30, 60, 120 or 180 min) the tumors were excised. The maximum depth and area of MAL penetration achieved in each lesion was measured using PpIX fluorescence microscopy. As expected, an increase in the depth of MAL-induced PpIX accumulation and area of tumor sensitized was observed over time; when the Metvix® cream was applied for 0, 30, 60, 120 and 180 min the median depth of PpIX fluorescence was 0%, 21%, 26.5%, 75.5% and 90%, respectively and the median area of tumor sensitized was 0%, 4%, 6%, 19% and 60%, respectively. As the investigation presented here did not include a control arm, the relative depths of fluorescence observed in this study were statistically compared (using the non-parametric Mann Whitney U test) with the results of our previous study where patients had Metvix® cream applied either with or without the standard pressure OPI device. When the higher pressure OPI device was employed compared to without OPI this increase was observed to be greater following 30, 120, and 180 min although overall not significantly (p=0.835). In addition, no significant difference between the higher pressure OPI device employed here and the previously investigated standard pressure OPI device was observed (p=0.403). However

  10. [Attitudes and beliefs regarding opioid maintenance treatment in Portugal: a survey to physicians, patients and opioid users].

    Science.gov (United States)

    Goulão, João

    2013-01-01

    Introdução: Existem poucos estudos pan-europeus sobre programas terapêuticos com agonistas opiáceos, tanto da perspectiva dos prescritores, como dos doentes que os recebem e dos utilizadores de opióides que se mantêm fora do sistema de tratamento. O projecto ACCESS, um estudo europeu realizado em 11 países, explorou as atitudes e percepções dos médicos, doentes e utilizadores de opióides quanto à qualidade e ao acesso aos programas terapêuticos com agonistas opiáceos. O presente artigo descreve os principais resultados para Portugal.Material e Métodos: Os médicos que tratam doentes dependentes de opióides com recurso a programas terapêuticos com agonistas opiáceos foram inquiridos por entrevista directa; os doentes em programas terapêuticos com agonistas opiáceos, os doentes que não se encontravam em programas terapêuticos com agonistas opiáceos (em tratamento não farmacológico), e os utilizadores activos (pessoas dependentes de opióides que não se encontram actualmente em tratamento) receberam questionários de auto-preenchimento.Resultados: Verificou-se que, tanto os médicos como os doentes avaliam como ‘Bom’ o tratamento dos dependentes de opióides, em Portugal. O acesso ao tratamento foi considerado ‘Fácil’ pela maioria dos doentes e dos médicos, registando-se um elevado nível de satisfação entre os doentes. Contudo, o conhecimento dos doentes quanto às opções dos programas terapêuticos com agonistas opiáceos em Portugal encontra-se ainda abaixo do nível óptimo e as doses dos fármacos dos programas terapêuticos com agonistas opiáceos são frequentemente baixas.Discussão: Os resultados do projecto ACCESS, no que diz respeito a PTAO, são encorajadores e evidenciam quer as áreas de sucesso, quer as áreas que podem ser melhoradas no futuro, no que diz respeito ao sistema de tratamento de dependências de opióides em Portugal.Conclusões: O projecto ACCESS faz uma avaliação importante das atitudes e percep

  11. Cone beam computed tomography: An accurate imaging technique in comparison with orthogonal portal imaging in intensity-modulated radiotherapy for prostate cancer

    Directory of Open Access Journals (Sweden)

    Om Prakash Gurjar

    2016-03-01

    Full Text Available Purpose: Various factors cause geometric uncertainties during prostate radiotherapy, including interfractional and intrafractional patient motions, organ motion, and daily setup errors. This may lead to increased normal tissue complications when a high dose to the prostate is administered. More-accurate treatment delivery is possible with daily imaging and localization of the prostate. This study aims to measure the shift of the prostate by using kilovoltage (kV cone beam computed tomography (CBCT after position verification by kV orthogonal portal imaging (OPI.Methods: Position verification in 10 patients with prostate cancer was performed by using OPI followed by CBCT before treatment delivery in 25 sessions per patient. In each session, OPI was performed by using an on-board imaging (OBI system and pelvic bone-to-pelvic bone matching was performed. After applying the noted shift by using OPI, CBCT was performed by using the OBI system and prostate-to-prostate matching was performed. The isocenter shifts along all three translational directions in both techniques were combined into a three-dimensional (3-D iso-displacement vector (IDV.Results: The mean (SD IDV (in centimeters calculated during the 250 imaging sessions was 0.931 (0.598, median 0.825 for OPI and 0.515 (336, median 0.43 for CBCT, p-value was less than 0.0001 which shows extremely statistical significant difference.Conclusion: Even after bone-to-bone matching by using OPI, a significant shift in prostate was observed on CBCT. This study concludes that imaging with CBCT provides a more accurate prostate localization than the OPI technique. Hence, CBCT should be chosen as the preferred imaging technique.

  12. Comparison of DC and AC Transport in 1.5-7.5 nm Oligophenylene Imine Molecular Wires across Two Junction Platforms: Eutectic Ga-In versus Conducting Probe Atomic Force Microscope Junctions.

    Science.gov (United States)

    Sangeeth, C S Suchand; Demissie, Abel T; Yuan, Li; Wang, Tao; Frisbie, C Daniel; Nijhuis, Christian A

    2016-06-15

    We have utilized DC and AC transport measurements to measure the resistance and capacitance of thin films of conjugated oligophenyleneimine (OPI) molecules ranging from 1.5 to 7.5 nm in length. These films were synthesized on Au surfaces utilizing the imine condensation chemistry between terephthalaldehyde and 1,4-benzenediamine. Near edge X-ray absorption fine structure (NEXAFS) spectroscopy yielded molecular tilt angles of 33-43°. To probe DC and AC transport, we employed Au-S-OPI//GaOx/EGaIn junctions having contact areas of 9.6 × 10(2) μm(2) (10(9) nm(2)) and compared to previously reported DC results on the same OPI system obtained using Au-S-OPI//Au conducting probe atomic force microscopy (CP-AFM) junctions with 50 nm(2) areas. We found that intensive observables agreed very well across the two junction platforms. Specifically, the EGaIn-based junctions showed: (i) a crossover from tunneling to hopping transport at molecular lengths near 4 nm; (ii) activated transport for wires >4 nm in length with an activation energy of 0.245 ± 0.008 eV for OPI-7; (iii) exponential dependence of conductance with molecular length with a decay constant β = 2.84 ± 0.18 nm(-1) (DC) and 2.92 ± 0.13 nm(-1) (AC) in the tunneling regime, and an apparent β = 1.01 ± 0.08 nm(-1) (DC) and 0.99 ± 0.11 nm(-1) (AC) in the hopping regime; (iv) previously unreported dielectric constant of 4.3 ± 0.2 along the OPI wires. However, the absolute resistances of Au-S-OPI//GaOx/EGaIn junctions were approximately 100 times higher than the corresponding CP-AFM junctions due to differences in metal-molecule contact resistances between the two platforms.

  13. Estudo da inclinação do plano palatino em relação à base posterior do crânio em indivíduos portadores de oclusão normal Study of palatal plane inclination related to the posterior cranial base in subjects with normal occlusion

    Directory of Open Access Journals (Sweden)

    Cássia T. Lopes de Alcântara Gil

    2006-10-01

    Full Text Available OBJETIVO: estudar a relação entre o plano palatino e a região posterior da base do crânio, em indivíduos portadores de oclusão normal. METODOLOGIA: a amostra foi constituída por telerradiografias em norma lateral de 95 indivíduos portadores de oclusão normal natural. O plano palatino foi determinado pelos pontos Ena e Enp (Espinha Nasal Anterior e Posterior. Utilizou-se o ponto mais posterior e inferior do osso occipital (OPI, para definição da região póstero-inferior da base do crânio. Avaliou-se o comportamento do ângulo formado pelos planos OPI-Ena e Ena-Enp, denominado ângulo OPI.Ena.Enp, tendo como vértice o ponto Ena. Desta forma, valores angulares próximos a 0º indicaram tendência à coincidência entre os planos OPI-Ena e Ena-Enp, o que equivale a dizer que, nestes casos, a extensão do plano palatino tangencia a base posterior do crânio, representada pelo Ponto OPI. RESULTADOS: a média de valor encontrada em relação ao ângulo OPI.Ena.Enp na referida amostra foi de -0,13º, valor próximo a zero, indicando tendência à coincidência entre os planos OPI-Ena e Ena-Enp. CONCLUSÃO: os resultados indicam que em pacientes portadores de oclusão normal natural, o prolongamento do plano palatino tende a tangenciar a região posterior da base do crânio, o que se revela uma característica estrutural em crânios de indivíduos portadores de oclusão equilibrada.AIM: to study the inclination of the palatal plane in 95 subjects with clinically normal occlusion. METHODS: the study was made using lateral headfilms and the results showed that in normal occlusion the extension of the palatal plane (ANS-PNS passes trough the most posterior and inferior region of the skull, defined as Point "OPI". RESULTS: OPI.Ena.Enp mean value was -0.13º, close to zero. CONCLUSION: the results indicated that in normal occlusion patients the palatal plane presents a tendency to be tangent with posterior cranial base.

  14. Bringing Control System User Interfaces to the Web

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xihui [ORNL; Kasemir, Kay [ORNL

    2013-01-01

    With the evolution of web based technologies, especially HTML5 [1], it becomes possible to create web-based control system user interfaces (UI) that are cross-browser and cross-device compatible. This article describes two technologies that facilitate this goal. The first one is the WebOPI [2], which can seamlessly display CSS BOY [3] Operator Interfaces (OPI) in web browsers without modification to the original OPI file. The WebOPI leverages the powerful graphical editing capabilities of BOY and provides the convenience of re-using existing OPI files. On the other hand, it uses generic JavaScript and a generic communication mechanism between the web browser and web server. It is not optimized for a control system, which results in unnecessary network traffic and resource usage. Our second technology is the WebSocket-based Process Data Access (WebPDA) [4]. It is a protocol that provides efficient control system data communication using WebSocket [5], so that users can create web-based control system UIs using standard web page technologies such as HTML, CSS and JavaScript. WebPDA is control system independent, potentially supporting any type of control system.

  15. Agrometeorological models for groundnut crop yield forecasting in the Jaboticabal, São Paulo State region, Brazil

    Directory of Open Access Journals (Sweden)

    Victor Brunini Moreto

    2015-10-01

    Full Text Available Forecast is the act of estimating a future event based on current data. Ten-day period (TDP meteorological data were used for modeling: mean air temperature, precipitation and water balance components (water deficit (DEF and surplus (EXC and soil water storage (SWS. Meteorological and yield data from 1990-2004 were used for calibration, and 2005-2010 were used for testing. First step was the selection of variables via correlation analysis to determine which TDP and climatic variables have more influence on the crop yield. The selected variables were used to construct models by multiple linear regression, using a stepwise backwards process. Among all analyzed models, the following was notable: Yield = - 4.964 x [SWS of 2° TDP of December of the previous year (OPY] – 1.123 x [SWS of 2° TDP of November OPY] + 0.949 x [EXC of 1° TDP of February of the productive year (PY] + 2.5 x [SWS of 2° TDP of February OPY] + 19.125 x [EXC of 1° TDP of May OPY] – 3.113 x [EXC of 3° TDP of January OPY] + 1.469 x [EXC of 3 TDP of January of PY] + 3920.526, with MAPE = 5.22%, R2 = 0.58 and RMSEs = 111.03 kg ha-1.

  16. Surfactant-directed polypyrrole/CNT nanocables: synthesis, characterization, and enhanced electrical properties.

    Science.gov (United States)

    Zhang, Xuetong; Zhang, Jin; Wang, Rongming; Zhu, Tao; Liu, Zhongfan

    2004-07-19

    We describe here a new approach to the synthesis of size-controllable polypyrrole/carbon nanotube (CNT) nanocables by in situ chemical oxidative polymerization directed by the cationic surfactant cetyltrimethylammonium bromide (CTAB) or the nonionic surfactant polyethylene glycol mono-p-nonylphenyl ether (Opi-10). When carbon nanotubes are dispersed in a solution containing a certain concentration of CTAB or Opi-10, the surfactant molecules are adsorbed and arranged regularly on the CNT surfaces. On addition of pyrrole, some of the monomer is adsorbed at the surface of CNTs and/or wedged between the arranged CTAB or Opi-10 molecules. When ammonium persulfate (APS) is added, pyrrole is polymerized in situ at the surfaces of the CNTs (core layer) and ultimately forms the outer shell of the nanocables. Such polypyrrole/CNT nanocables show enhanced electrical properties; a negative temperature coefficient of resistance at 77-300 K and a negative magnetoresistance at 10-200 K were observed.

  17. Decision Support Systems for Research and Management in Advanced Life Support

    Science.gov (United States)

    Rodriquez, Luis F.

    2004-01-01

    Decision support systems have been implemented in many applications including strategic planning for battlefield scenarios, corporate decision making for business planning, production planning and control systems, and recommendation generators like those on Amazon.com(Registered TradeMark). Such tools are reviewed for developing a similar tool for NASA's ALS Program. DSS are considered concurrently with the development of the OPIS system, a database designed for chronicling of research and development in ALS. By utilizing the OPIS database, it is anticipated that decision support can be provided to increase the quality of decisions by ALS managers and researchers.

  18. Side effects of subarachnoid and epidural sufentanil associated with a local anesthetic in patients undergoing labor analgesia

    OpenAIRE

    Salem, Isabel C.F. [UNESP; Fernanda B. Fukushima; Giane Nakamura; Fábio Ferrari; Navarro,Laís C.; Yara Marcondes Machado Castiglia; Eliana Marisa Ganem

    2007-01-01

    JUSTIFICATIVA E OBJETIVOS: A associação do opióide ao anestésico local melhora a qualidade da analgesia de parto e reduz o risco de toxicidade sistêmica pelo anestésico local. Os opióides, entretanto, podem determinar efeitos colaterais. O objetivo desta pesquisa foi comparar os efeitos adversos determinados pelo sufentanil, administrado por via subaracnóidea, associado à bupivacaína, com aquele determinado pelo sufentanil por via peridural, associado à ropivacaína, nas doses utilizadas no Se...

  19. IZDELAVA VIRTUALNEGA SEJMA S TEHNOLOGIJO X3D

    OpenAIRE

    Lešnik, Marko

    2010-01-01

    V diplomskem delu opišemo proces izdelave sveta navidezne resničnosti, ki simulira okolje sejemskih hal z razstavnimi prostori razstavljalcev ter omogoča obiskovalcu, da se po sejmu prosto sprehaja v spletnem brskalniku. Takšno interaktivno predstavitev sejma v obliki 3D sveta poimenujemo virtualni sejem. Preučili in uporabili smo standardni jezik za opis svetov navidezne resničnosti X3D, ki nam omogoča izgradnjo prototipov 3D gradnikov sveta, katere smo združili v knjižnico objektov X3D. Zas...

  20. Optimal Path Identification Using ANT Colony Optimisation in Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Aniket. A. Gurav

    2013-05-01

    Full Text Available Wireless Sensor Network WSN is tightly constrained for energy, computational power and memory. All applications of WSN require to forward data from remote sensor node SN to base station BS. The path length and numbers of nodes in path by which data is forwarded affect the basic performance of WSN. In this paper we present bio-Inspired Ant Colony Optimisation ACO algorithm for Optimal path Identification OPI for p acket transmission to communicate between SN to BS. Our modified algorithm OPI using ACO cons iders the path length and the number of hops in path for data packet transmission, with an aim to reduce communication overheads .

  1. Efectividad de morfina intratecal versus endovenosa / histerectomía vaginal en el Hospital Occidente de Kennedy

    OpenAIRE

    2009-01-01

    Introducción: la histerectomía vaginal es una cirugía frecuente, esta investigación comparo dos vías de suministro de opiáceos: intratecal y endovenosa en un estudio realizado en el Hospital Occidente de Kennedy. Método: Estudio prospectivo observacional comparando dolor utilizando la escala de dolor numérica verbal y determinando los requerimientos de morfina de rescate y o Aines, describiendo la presencia de efectos secundarios del uso de opiáceos en dos grupos. Resultados: Particip...

  2. POSODOBITEV SPLETNEGA PORTALA E-GRADIV FAKULTETE ZA LOGISTIKO

    OpenAIRE

    Kajba, Zoran

    2013-01-01

    V diplomskem delu opišemo posodobitev portala Blend.Fl iz sistema za upravljanje vsebin Joomla 1.0 na verzijo 2.5. Portal Blend.Fl vsebuje komponente za delo z elektronskimi gradivi. Opišemo sistem za upravljanje vsebin Joomla in njegove razširitve, kjer smo implementacijo komponent dodatno preučili in prikazali. Predstavimo tudi komponenti sistema e-gradiv in njuno delovanje. Komponenti sta namenjeni urejanju poglavij in gradiv, namenjenih študentom Fakultete za logistiko, v povezavi s h...

  3. Charge Transport in 4 nm Molecular Wires with Interrupted Conjugation: Combined Experimental and Computational Evidence for Thermally Assisted Polaron Tunneling.

    Science.gov (United States)

    Taherinia, Davood; Smith, Christopher E; Ghosh, Soumen; Odoh, Samuel O; Balhorn, Luke; Gagliardi, Laura; Cramer, Christopher J; Frisbie, C Daniel

    2016-04-26

    We report the synthesis, transport measurements, and electronic structure of conjugation-broken oligophenyleneimine (CB-OPI 6) molecular wires with lengths of ∼4 nm. The wires were grown from Au surfaces using stepwise aryl imine condensation reactions between 1,4-diaminobenzene and terephthalaldehyde (1,4-benzenedicarbaldehyde). Saturated spacers (conjugation breakers) were introduced into the molecular backbone by replacing the aromatic diamine with trans-1,4-diaminocyclohexane at specific steps during the growth processes. FT-IR and ellipsometry were used to follow the imination reactions on Au surfaces. Surface coverages (∼4 molecules/nm(2)) and electronic structures of the wires were determined by cyclic voltammetry and UV-vis spectroscopy, respectively. The current-voltage (I-V) characteristics of the wires were acquired using conducting probe atomic force microscopy (CP-AFM) in which an Au-coated AFM probe was brought into contact with the wires to form metal-molecule-metal junctions with contact areas of ∼50 nm(2). The low bias resistance increased with the number of saturated spacers, but was not sensitive to the position of the spacer within the wire. Temperature dependent measurements of resistance were consistent with a localized charge (polaron) hopping mechanism in all of the wires. Activation energies were in the range of 0.18-0.26 eV (4.2-6.0 kcal/mol) with the highest belonging to the fully conjugated OPI 6 wire and the lowest to the CB3,5-OPI 6 wire (the wire with two saturated spacers). For the two other wires with a single conjugation breaker, CB3-OPI 6 and CB5-OPI 6, activation energies of 0.20 eV (4.6 kcal/mol) and 0.21 eV (4.8 kcal/mol) were found, respectively. Computational studies using density functional theory confirmed the polaronic nature of charge carriers but predicted that the semiclassical activation energy of hopping should be higher for CB-OPI molecular wires than for the OPI 6 wire. To reconcile the experimental and

  4. VISOKO GOSPODARSKO UČILIŠTE U KRIŽEVCIMA PRILOG OBRAZOVANJU ZA ODRŽIVU I EKOLOŠKU POLJOPRIVREDU

    OpenAIRE

    2009-01-01

    Rad daje pregled uloge koju ima Visoko gospodarsko učilište u Križevcima u području stručnih studija za poljoprivredu u Hrvatskoj i doprinos visokoškolskom obrazovanju za održivu i ekološku poljoprivredu. U radu se također donosi kratki opis povijesnoga razvoja križevačkoga Učilišta i opis suvremenih studijskih programa na razini stručnog i specijalističkog diplomskog studija te specijalističkih seminara u sklopu cjeloživotnoga učenja.

  5. 3-BARVANJE GRAFOV IN OPTIMIZACIJA Z ROJI DELCEV

    OpenAIRE

    Krauser, Aleš

    2009-01-01

    Optimizacija z roji delcev je relativno nova evolucijska tehnika, ki je bila prvotno razvita za reševanje zveznih problemov. Kasneje so se pojavile različne izvedbe za reševanje diskretnih problemov. Na začetku se seznanimo z osnovno in diskretno optimizacijo z roji delcev. Nato spoznamo parametre, ki nastopajo v optimizaciji z roji delcev. Opišemo problem 3-barvanja grafov, ki smo ga izbrali kot diskretni problem za izvajanje optimizacije z roji delcev. Temu sledi opis znanih tradicionalnih ...

  6. Synthesis, characterization and study of the magnetic properties of a coordination polymer containing cobalt(II) and copper(II); Sintese, caracterizacao e estudo das propriedades magneticas de um polimero de coordenacao contendo cobalto(II) e cobre(II)

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Tamyris T. da; Stumpf, Humberto O.; Pereira, Cynthia L.M., E-mail: cynthialopes@ufmg.br [Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil); Pires, Heber S.; Oliveira, Luiz F.C. de [Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Juiz de Fora, MG (Brazil); Pedroso, Emerson F. [Departamento de Quimica, Centro Federal de Educacao Tecnologica de Minas Gerais, Belo Horizonte, MG (Brazil); Nunes, Wallace C. [Instituto de Fisica, Universidade Federal Fluminense, Niteroi, RJ (Brazil)

    2012-07-01

    This work describes the synthesis and characterization of two new compounds with ligand opy (N-(2-pyridyl)oxamate): the copper(II) precursor [Me{sub 4}N]{sub 2}[Cu(opy){sub 2}].5H{sub 2}O and Co{sup II} Cu{sup II} coordination polymer {l_brace}[Co Cu(opy){sub 2}]{r_brace}{sub n}x4nH{sub 2}O. This latter compound was obtained by reaction of [Me{sub 4}N]{sub 2}[Cu(opy){sub 2}].5H{sub 2}O and CoCl{sub 2}.6H{sub 2}O in water. The heterobimetallic Co{sup II} Cu{sup II} chain was characterized by elemental analysis, IR spectroscopy, thermogravimetry and magnetic measurements. Magnetic characterization revealed typical behavior of one-dimensional (1D) ferrimagnetic chain as shown in the curves of temperature (T) dependence of magnetic susceptibility ({chi}{sub M}), in the form of {chi}{sub M}T versus T, and dependence of magnetization (M) with applied field (H). (author)

  7. FIZIKALNA ANALIZA IN DIMENZIONIRANJE PROGE VLAKA SMRTI

    OpenAIRE

    Meh, Anže

    2016-01-01

    V diplomskem delu so predstavljene osnove, ki so potrebne za projektiranje vlakov smrti. V uvodnem delu je predstavljena kratka zgodovina vlakov smrti, njihova razvrstitev in grob opis njihovega sestava in delovanja. Drugi del prikazuje podrobnosti njihovega delovanja in matematično ter fizikalno analizo najpogosteje uporabljenih elementov. V tretjem delu pa je na primeru odseka proge vlaka smrti na grobo prikazano njegovo dimenzioniranje.

  8. DMPD: MDA5/RIG-I and virus recognition. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18272355 MDA5/RIG-I and virus recognition. Takeuchi O, Akira S. Curr Opin Immunol. ...2008 Feb;20(1):17-22. Epub 2008 Feb 12. (.png) (.svg) (.html) (.csml) Show MDA5/RIG-I and virus recognition.... PubmedID 18272355 Title MDA5/RIG-I and virus recognition. Authors Takeuchi O, Akira S. Publication Curr Opi

  9. Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast

    Energy Technology Data Exchange (ETDEWEB)

    Barajas, Daniel; Xu, Kai; Sharma, Monika; Wu, Cheng-Yu; Nagy, Peter D., E-mail: pdnagy2@uky.edu

    2014-12-15

    Positive-stranded RNA viruses induce new membranous structures and promote membrane proliferation in infected cells to facilitate viral replication. In this paper, the authors show that a plant-infecting tombusvirus upregulates transcription of phospholipid biosynthesis genes, such as INO1, OPI3 and CHO1, and increases phospholipid levels in yeast model host. This is accomplished by the viral p33 replication protein, which interacts with Opi1p FFAT domain protein and Scs2p VAP protein. Opi1p and Scs2p are phospholipid sensor proteins and they repress the expression of phospholipid genes. Accordingly, deletion of OPI1 transcription repressor in yeast has a stimulatory effect on TBSV RNA accumulation and enhanced tombusvirus replicase activity in an in vitro assay. Altogether, the presented data convincingly demonstrate that de novo lipid biosynthesis is required for optimal TBSV replication. Overall, this work reveals that a (+)RNA virus reprograms the phospholipid biosynthesis pathway in a unique way to facilitate its replication in yeast cells. - Highlights: • Tombusvirus p33 replication protein interacts with FFAT-domain host protein. • Tombusvirus replication leads to upregulation of phospholipids. • Tombusvirus replication depends on de novo lipid synthesis. • Deletion of FFAT-domain host protein enhances TBSV replication. • TBSV rewires host phospholipid synthesis.

  10. The Impact of Vasoactive Drugs on Oxygenation and Tissue Perfusion

    Science.gov (United States)

    1992-01-01

    useful in the management of congestive heart failure, cardiogenic pulmonary edema , mitral or aortic regurgitation and persistent chest pain...administration include refractory cardiac failure, cardiogenic shock, septic shock, post cardiac surgery, and acute renal failure (Opie, 1991; Budnv... cardiogenic , anaphylactic, and septic shock, and cardiac arrest (Zaritsky & Eisenberg, 1986). Affect on Oxygenation and Tissue Perfusion Epinephrine, as with

  11. Special Operations Forces Language and Culture Needs Assessment Project: Defense Language Aptitude Battery (DLAB): Perspectives from the Field

    Science.gov (United States)

    2010-09-29

    Proficiency Interview (OPI). These studies compared the DLAB to alternatives, such as the Armed Forces Qualification Test (AFQT) and the Wonderlic ...1 This test is now referred to as the Wonderlic Classic Cognitive Ability Test by...the test developers; however, the test will be referred to as the Wonderlic Personnel Test (WPT) in this report. SOF Language and Culture Needs

  12. Detection of physiological changes after exercise via a remote optophysiological imaging system

    Science.gov (United States)

    Sun, Yu; Hu, Sijung; Azorin-Peris, Vicente; Zheng, Jia; Greenwald, Stephen; Chambers, Jonathon; Zhu, Yisheng

    2011-03-01

    A study of blood perfusion mapping was performed with a remote opto-physiological imaging (OPI) system coupling a sensitive CMOS camera and a custom-built resonant cavity light emitting diode (RCLED) ringlight. The setup is suitable for the remote assessment of blood perfusion in tissue over a wide range of anatomical locations. The purpose of this study is to evaluate the reliability and stability of the OPI system when measuring a cardiovascular variable of clinical interest, in this case, heart rate. To this end, the non-contact and contact photoplethysmographic (PPG) signals obtained from the OPI system and conventional PPG sensor were recorded simultaneously from each of 12 subjects before and after 5-min of cycling exercise. The time-frequency representation (TFR) method was used to visualize the time-dependent behavior of the signal frequency. The physiological parameters derived from the images captured by the OPI system exhibit comparable functional characteristics to those taken from conventional contact PPG pulse waveform measurements in both the time and frequency domains. Finally and more importantly, a previously developed opto-physiological model was employed to provide a 3-D representation of blood perfusion in human tissue which could provide a new insight into clinical assessment and diagnosis of circulatory pathology in various tissue segments.

  13. Transformative Colloidal Nanomaterials for Mid- Infrared Devices

    Science.gov (United States)

    2015-06-11

    446 (2005) [2] Hillhouse, H.W., Beard, M.C., “Solar cells from colloidal nanocrystals: Fundamentals, materials, devices, and economics ,” Curr. Op...I., Fischer , A., Hoogland, S., Clifford, J., Klem, E., Levina, L., Sargent, EH., “Ultrasensitive solution-cast quantum dot photodetectors

  14. West Indian Sojourners in Guatemala and Honduras

    Directory of Open Access Journals (Sweden)

    Ronald N. Harpelle

    2012-12-01

    Full Text Available Review of: Race, Nation, and West Indian Immigration to Honduras, 1890-1940. Glenn A. Chambers. Baton Rouge: Louisiana State University Press, 2010. xii +202 pp. (Cloth US$ 35.00Black Labor Migration in Caribbean Guatemala, 1882-1923. Frederick Douglass Opie. Gainesville: University Press of Florida, 2009. 145 pp. (Cloth US$ 65.00

  15. Floating on the Sea of Knowledge

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Edl’tor’8ante:ChinaisCelphratjng.theSOthanniVersaryfifthsfoundingofmePeOPle’sRepubliC.In1949China:brought10OpersOfhumiliationtoanendandthaPeOPleCh$4redwbpnMaoZedonganrtpunCedfroaltherostrumd(thte;GateofHeavenlyPeaceohTian’anmenSquare.t’ChifleS6peOPIS...

  16. Problems in Examining the Validity of the ACTFL Oral Proficiency Interview.

    Science.gov (United States)

    Bachman, Lyle F.

    1988-01-01

    Discusses the problem of measuring the validity of interview ratings in the American Council on the Teaching of Foreign Languages (ACTFL) Oral Proficiency Interviews (OPI), proposes frameworks to distinguish abilities from testing methods, and considers factors affecting test performance. Suggestions for research and development on the ACTFL OPI…

  17. Opinion Leaders' Role in Innovation Diffusion : A Simulation Study

    NARCIS (Netherlands)

    van Eck, P.S.; Leeflang, P.S.H.; Jager, W.

    2011-01-01

    This study investigates the critical role that opinion leaders (or influentials) play in the adoption process of new products. Recent existing reseach evidence indicates a limited effect of opinion leaders on diffusion processes, yet these studies take into account merely the network position of opi

  18. Dicty_cDB: Contig-U10387-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1093015537142 Global-Ocean-Sampling_GS-35-01-01-1... 46 1.3 1 ( FG600026 ) PF_T3_08R_A10_25JUL2003_080 Opi...um poppy root cDNA... 46 1.3 1 ( EW991615 ) LJGD-L7_G03 Adult female Lutzomyia long

  19. Another Look at Correlations between the Oral Proficiency Interview and the Zertifikat Deutsch als Fremdsprache.

    Science.gov (United States)

    Vazulik, Johannes; Brown, Cheri

    A study supplementing earlier research by Lalande and Schweckendiek investigated comparisons and correlations obtained from testing a group of 17 university students of German using both the American Council on the Teaching of Foreign Languages (ACTFL) Oral Proficiency Interview (OPI) and the most recent revision of the examination for the…

  20. Talking and Testing: Discourse Approaches to the Assessment of Oral Proficiency. Studies in Bilingualism, Volume 14.

    Science.gov (United States)

    Young, Richard, Ed.; He, Agnes Weiyun, Ed.

    Papers on second language oral proficiency testing include: "Language Proficiency Interviews: A Discourse Approach" (Agnes Weiyun He, Richard Young); "Re-Analyzing the OPI: How Much Does It Look Like Natural Conversation?" (Marysia Johnson, Andrea Tyler); "Evaluating Learner Interactional Skills: Conversation at the Micro Level" (Heidi…

  1. Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast.

    Science.gov (United States)

    Hickman, Mark J; Petti, Allegra A; Ho-Shing, Olivia; Silverman, Sanford J; McIsaac, R Scott; Lee, Traci A; Botstein, David

    2011-11-01

    A yeast strain lacking Met4p, the primary transcriptional regulator of the sulfur assimilation pathway, cannot synthesize methionine. This apparently simple auxotroph did not grow well in rich media containing excess methionine, forming small colonies on yeast extract/peptone/dextrose plates. Faster-growing large colonies were abundant when overnight cultures were plated, suggesting that spontaneous suppressors of the growth defect arise with high frequency. To identify the suppressor mutations, we used genome-wide single-nucleotide polymorphism and standard genetic analyses. The most common suppressors were loss-of-function mutations in OPI1, encoding a transcriptional repressor of phospholipid metabolism. Using a new system that allows rapid and specific degradation of Met4p, we could study the dynamic expression of all genes following loss of Met4p. Experiments using this system with and without Opi1p showed that Met4 activates and Opi1p represses genes that maintain levels of S-adenosylmethionine (SAM), the substrate for most methyltransferase reactions. Cells lacking Met4p grow normally when either SAM is added to the media or one of the SAM synthetase genes is overexpressed. SAM is used as a methyl donor in three Opi1p-regulated reactions to create the abundant membrane phospholipid, phosphatidylcholine. Our results show that rapidly growing cells require significant methylation, likely for the biosynthesis of phospholipids.

  2. The Development and Validation of a Korean C-Test Using Rasch Analysis

    Science.gov (United States)

    Lee-Ellis, Sunyoung

    2009-01-01

    Despite the importance of having a reliable and valid measure of Second Language (L2) proficiency, L2 researchers of less commonly taught languages rarely have such a tool. Existing proficiency measures (e.g., DLPT, OPI) are often costly, labor-intensive, time-consuming, or unavailable to the public. With the intent to provide a practical and…

  3. Reliability and the ACTFL Oral Proficiency Interview: Reporting Indices of Interrater Consistency and Agreement for 19 Languages

    Science.gov (United States)

    Surface, Eric A.; Dierdorff, Erich C.

    2003-01-01

    The reliability of the ACTFL Oral Proficiency Interview (OPI) has not been reported since ACTFL revised its speaking proficiency guidelines in 1999. Reliability data for assessments should be reported periodically to provide users with enough information to evaluate the psychometric characteristics of the assessment. This study provided the most…

  4. RAPD markers associated with resistance to blackleg disease in ...

    African Journals Online (AJOL)

    user

    2006-11-16

    Nov 16, 2006 ... OPE12, and OPI01) were polymorphic, while the SSR markers were monomorphic. Chi-square analysis indicated that 5 .... Therefore, molecular markers linked to resistant genes must be developed so that, the ..... The polymorphism information content (PIC value) indi- cates that some primers were more ...

  5. How groups contest depends on group power and the likelihood that power determines victory and defeat

    NARCIS (Netherlands)

    Kamans, Elanor; Otten, Sabine; Gordijn, Ernestine H.; Spears, Russell

    2010-01-01

    The aim of the current study was to show that the type of conflict behavior (constructive vs. unconstructive) groups use in conflicts depends on their power position as well as the likelihood that power determines victory and defeat. In an alleged online debate, we created a conflict between two opi

  6. Another Look at Correlations between the Oral Proficiency Interview and the Zertifikat Deutsch als Fremdsprache.

    Science.gov (United States)

    Vazulik, Johannes; Brown, Cheri

    A study supplementing earlier research by Lalande and Schweckendiek investigated comparisons and correlations obtained from testing a group of 17 university students of German using both the American Council on the Teaching of Foreign Languages (ACTFL) Oral Proficiency Interview (OPI) and the most recent revision of the examination for the…

  7. Disease: H00381 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available rol 11:301-11 (2001) PMID:21514129 Coller BA, Clements DE Dengue vaccines: progress and challenges. Curr Opi...f dengue. Vaccine 29:7221-8 (2011) PMID:11590668 (deacription) Kurane I, Takasaki T Dengue fever and dengue haemorrhagic fever: chall...enges of controlling an enemy still at large. Rev Med Vi

  8. 75 FR 82026 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

    Science.gov (United States)

    2010-12-29

    ... G Donata Holding SE. G Miriam Schaeffer. G OPI Products Inc. 20110306 G Zensar Technologies, Ltd. G... Medical Edge Healthcare Group, P.A. 20110336 G Everest Re Group, Ltd. G Michael A. Miller. G Heartland... Laboratories, L.L.C. 20110252 G Energy XXI (Bermuda) Limited. G Exxon Mobil Corporation. G Mobile Eugene...

  9. Experiment list: SRX331076 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available he spatio-temporal expression pattern of C34F6.9::EGFP fusion protein was examined through in vivo microsc...opy. This strain was used for ChIP-seq experiments to map the in vivo binding sites

  10. Experiment list: SRX331074 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available he spatio-temporal expression pattern of C34F6.9::EGFP fusion protein was examined through in vivo microsc...opy. This strain was used for ChIP-seq experiments to map the in vivo binding sites

  11. GenBank blastx search result: AK104002 [KOME

    Lifescience Database Archive (English)

    Full Text Available opy of the insertion element IS2 is inserted after cloning in E.coli by duplicating a 5 base pair sequence. This is the wildtype TRP5 gene before insertion of IS2.|PLN PLN 6e-22 +1 ...

  12. Effects of exercise and supraphysiological dose of nandrolone decano-ate on the rat plasma opioid level: a brief report

    Directory of Open Access Journals (Sweden)

    Mehdi Mohebi

    2014-06-01

    Conclusion: In the present study we show that chronic nandrolone decanoate admin-istration attenuates effects of two weeks swimming exercise on serum opioid peptide and reduces the level of beta-endorphin and met-enkephalin. Keeping in mind that opi-oidergic system play an important role in behavior, athletes abusing anabolic steroid drugs may potentially experience changes in mood and behavior.

  13. Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae.

    Science.gov (United States)

    Sánchez-Fortún, S; Sanz, F; Barahona, M V

    1996-10-01

    The acute toxicity of chlorpyrifos, methylchlorpyrifos, parathion and methylparathion to three age classes of Artemia salina was determined. In general, A. salina 24-h old was less sensitive to these organophosphorous insecticides (OPI) than A. salina 48-h old and A. salina 48-h old was significantly more tolerant than A. salina 72-h old, in contrast, chlorpyrifos was equally toxic to A. salina 48- and 72-h old. There were some differences among the three age classes of A. salina in the relative order of toxicity of OPI tested. The rank order of toxicity to A. salina 48-h old was methylparathion salina 24- and 72-h old it was methylparathion = parathion Artemia salina 24-h old was investigated. The lethal action of OPI tested was completely prevented by pretreatment of Artemia salina 24-h old with 2-PAM (10(-5) M) and atropine (10(-4 )M). However no concentration of hexamethonium, pirenzepine or AF-DX 116 protected 100% of the animals poisoned by LC84 of the OPI selected, maximum protection obtained was 71 to 88%. In contrast, the maximum inhibition of mortality obtained with AF-DX 116 pretreatment was about 55% because this compound was used at concentrations which were non toxic to control Artemia salina. Atropine, hexamethonium, pirenzepine, AF-DX 116 and 2-PAM afforded 50 % protection (IC50) of Artemia salina against mortality by LC84 of the OPI selected at concentrations in the range of 6.62x10(-7)-1.6x10(-6) M, 2. 38x10(-4)-2.05x10(-3)M, 8.91x10(-7)-1.24x10(-6) M, 9.66x10(-8)-1. 34x10(-7 )M, and 1.95x10(-8)-2.73x10(-8 )M, respectively. Pretreatment of atropine plus 2-PAM to determine whether this combination afforded greater inhibition of the lethality induced by four OPI tested than pretreatment with either atropine or 2-PAM alone was investigated. Atropine (10(-5) M) in combination with 2-PAM (10(-7 )M) inhibited completely the acute toxicity of all OPI tested, while the pretreatment with atropine (10(-6) M) plus 2-PAM at the same concentration gave a

  14. Pyrolytic synthesis and luminescence of porous lanthanide Eu-MOF.

    Science.gov (United States)

    Jin, Guangya; Liu, Zhijian; Sun, Hongfa; Tian, Zhiyong

    2016-02-01

    A lanthanide metal coordination polymer [Eu2(BDC)3(DMSO)(H2O)] was synthesized by the reaction of europium oxide with benzene-1,3-dicarboxylic acid (H2BDC) in a mixed solution of dimethyl sulfoxide (DMSO) and water under hydrothermal conditions. The crystal structure of Eu2(BDC)3(DMSO)(H2O) was characterized by X-ray diffraction (XRD). Thermo-gravimetric analysis of Eu2(BDC)3(DMSO)(H2O) indicated that coordinated DMSO and H2O molecules could be removed to create Eu2(BDC)3(DMSO)(H2O)-py with permanent microporosity, which was also verified by powder XRD (PXRD) and elemental analysis. Both Eu2(BDC)3(DMSO)(H2O) and Eu2(BDC)3(DMSO)(H2O)-py showed mainly Eu-based luminescence and had characteristic emissions in the range 550-700 nm.

  15. STOCK MARKET WEALTH-EFFECTS DURING PRIVATIZATION INITIAL PUBLIC OFFERS IN CHILE (1984-1989

    Directory of Open Access Journals (Sweden)

    ROBERTO J. SANTILLÁN SALGADO

    2010-01-01

    económicas y políticas prevalecientes. En particular, se presentan los detalles operativos del mecanismo de emisión de acciones, complementado con un estudio estadístico de los Rendimientos Ajustados por el Mercado de las OPIs. Aunque el tamaño de la muestra es limitado y no permite alcanzar una validez externa, el análisis confirma la presencia de patrones de desempeño muy similares a los observados en OPIs tanto privadas como privatizadoras, de acuerdo con otros estudios relacionados (Aggarwal, Leal y Hernández, 1993; Dewenter y Malatesta, 1997; Loughran, Ritter y Rydqvist, 1994; Perotti y Guney, 1993.

  16. Designing low-complexity electrical consumer products for ecological use.

    Science.gov (United States)

    Sauer, Juergen; Wiese, Bettina S; Rüttinger, Bruno

    2003-11-01

    This study examined the environmental impact of low-complexity electrical consumer products during their use in a domestic context. In the experimental scenario, 48 users were asked to use a kettle under different conditions. On-product information (OPI), task instruction, and kettle design were employed as independent variables in a mixed multi-factorial design to examine their effects on different parameters of ecological performance (e.g., water and electricity consumption). Measures of user variables (environmental concern, knowledge, domestic habits, environmental control beliefs) were also taken to examine their relationship with performance parameters. The results revealed main effects of ecological task instruction, OPI and (partly) kettle design on ecological user behaviour. Habits, environmental concern and control beliefs were found to be related to performance parameters whereas knowledge was not. The implications of the results for product design are discussed against the background of a strong prevalence of habits and low ecological user motivation.

  17. Influência da codeína, associada ou não ao anestésico local, na duração do bloqueio sensitivo, motor e proprioceptivo do nervo ciático de rato

    OpenAIRE

    Talita Girio Carnaval

    2011-01-01

    A melhora na eficácia do bloqueio sensitivo induzida pela associação ou injeção prévia do opióide tramadol foi comprovada em animais e em humanos, sugerindo potencialização ou sinergismo de efeitos. No entanto, ainda não há estudos sobre a influência da associação da codeína ao anestésico local (AL) injetada concomitante ou previamente ao bloqueio funcional (sensitivo, motor e proprioceptivo) do nervo ciático. Dessa forma, o objetivo deste trabalho foi estudar a influência do analgésico opiói...

  18. EPICS Input/Output Controller (IOC) application developer`s guide. APS Release 3.12

    Energy Technology Data Exchange (ETDEWEB)

    Kraimer, M.R.

    1994-11-01

    This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers.

  19. Multiple Optimal Path Identification using Ant Colony Optimisation in Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Aniket. A. Gurav

    2013-10-01

    Full Text Available Wireless Sensor Network WSN is tightly constrained for resources like energy, computational power andmemory. Many applications of WSN require to communicate sensitive information at sensor nodes SN toBase station BS. The basic performance of WSN depends upon the path length and numbers of nodes in thepath by which data is forwarded to BS. In this paper we present bio-inspired Ant Colony Optimisation ACOalgorithm for Optimal Path Identification OPI for packet transmission to communicate between SN to BS.Our modified algorithm OPI using ACO is base-station driven which considers the path length and thenumber of hops in path for data packet transmission. This modified algorithm finds optimal path OP aswell as several suboptimal paths between SN & BS which are useful for effective communication.

  20. Synthesis and characterization of polymeric azido Zn(II) and Ni(II) complexes based on 3-hydroxypyridine

    Science.gov (United States)

    Mautner, Franz A.; Berger, Christian; Domian, Elisabeth; Fischer, Roland C.; Massoud, Salah S.

    2016-10-01

    The synthesis and structural characterization of two new complexes catena-[Ni(3-O-py)(3-HO-py)2(μ1,3-N3)(H2O)] (1) and catena-[Zn(μ-3-O-py)(μ1,1-N3)] (2), where 3-HO-py = 3-hydroxypyridine, are reported. The complexes were characterized by the elemental microanalyses, IR, and X-ray crystallography and by UV-Vis spectroscopy for complex 1. Single crystal X-ray crystallography revealed the polymeric nature of the complexes: 1 as 1D with a single EE azide bridging, and 2 as 2D with μ(O,O‧,N) bridging of the deprotonated 3-O-py anions and di-EO azide groups, respectively. In 1 the neutral and deprotonated 3-hydroxypyridine molecules act only as N-terminal ligands. The emission spectral properties of the Zn(II) complex were investigated.

  1. Izdelava kinematičnega modela in poprocesorja dvoosne stružnice v okolju Siemens NX

    OpenAIRE

    Kešpret, Sandi

    2014-01-01

    Magistrsko delo v prvem delu obravnava teoretične splošne osnove simulacij CNC strojev – stružnic. V nadaljevanju so obravnavane simulacije v programskem paketu Siemens NX. Jedro magistrske naloge zavzema podroben opis izdelave simulacije stroja CNC stružnice GF – NDM 16 ter poprocesorja. V zaključku sledijo komentar, analiza in primerjava dobljenih rezultatov z rezultati, dobljenimi s sorodnim programskim paketom.

  2. NCBI nr-aa BLAST: CBRC-OANA-01-2124 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OANA-01-2124 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-150 69% ...

  3. NCBI nr-aa BLAST: CBRC-ETEL-01-0228 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0228 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-149 91% ...

  4. NCBI nr-aa BLAST: CBRC-HSAP-20-0024 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-20-0024 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 0.0 100% ...

  5. NCBI nr-aa BLAST: CBRC-TBEL-01-1256 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-1256 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 4e-61 91% ...

  6. NCBI nr-aa BLAST: CBRC-PVAM-01-0526 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-0526 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-77 86% ...

  7. NCBI nr-aa BLAST: CBRC-PHAM-01-0451 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-0451 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 0.0 98% ...

  8. NCBI nr-aa BLAST: CBRC-ACAR-01-1160 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-1160 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-138 64% ...

  9. NCBI nr-aa BLAST: CBRC-CFAM-24-0010 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-24-0010 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 0.0 96% ...

  10. NCBI nr-aa BLAST: CBRC-MEUG-01-1362 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-1362 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-106 80% ...

  11. NCBI nr-aa BLAST: CBRC-TGUT-23-0006 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-23-0006 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-141 66% ...

  12. NCBI nr-aa BLAST: CBRC-GGAL-20-0003 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGAL-20-0003 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-141 66% ...

  13. NCBI nr-aa BLAST: CBRC-MMUR-01-0596 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-0596 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 0.0 96% ...

  14. NCBI nr-aa BLAST: CBRC-PABE-21-0028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-21-0028 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 0.0 98% ...

  15. NCBI nr-aa BLAST: CBRC-MLUC-01-0678 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0678 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 0.0 91% ...

  16. NCBI nr-aa BLAST: CBRC-CJAC-01-0417 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0417 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-121 99% ...

  17. NCBI nr-aa BLAST: CBRC-DNOV-01-1501 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1501 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-152 92% ...

  18. NCBI nr-aa BLAST: CBRC-EEUR-01-1541 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1541 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 2e-82 88% ...

  19. NCBI nr-aa BLAST: CBRC-MDOM-01-0382 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-01-0382 gb|AAV38759.1| opiate receptor-like 1 [synthetic construct] gb|AAV38760.1| opiate... receptor-like 1 [synthetic construct] gb|AAX43081.1| opiate receptor-like 1 [synthetic construct] gb|AAX43082.1| opi...ate receptor-like 1 [synthetic construct] AAV38759.1 1e-171 79% ...

  20. De l'importance des orbites periodiques: Detection et applications

    Science.gov (United States)

    Doyon, Bernard

    L'ensemble des Orbites Periodiques Instables (OPIs) d'un systeme chaotique est intimement relie a ses proprietes dynamiques. A partir de l'ensemble (en principe infini) d'OPIs cachees dans l'espace des phases, on peut obtenir des quantites dynamiques importantes telles les exposants de Lyapunov, la mesure invariante, l'entropie topologique et la dimension fractale. En chaos quantique (i.e. l'etude de systemes quantiques qui ont un equivalent chaotique dans la limite classique), ces memes OPIs permettent de faire le pont entre le comportement classique et quantique de systemes non-integrables. La localisation de ces cycles fondamentaux est un probleme complexe. Cette these aborde dans un premier temps le probleme de la detection des OPIs dans les systemes chaotiques. Une etude comparative de deux algorithmes recents est presentee. Nous approfondissons ces deux methodes afin de les utiliser sur differents systemes dont des flots continus dissipatifs et conservatifs. Une analyse du taux de convergence des algorithmes est aussi realisee afin de degager les forces et les limites de ces schemes numeriques. Les methodes de detection que nous utilisons reposent sur une transformation particuliere de la dynamique initiale. Cette astuce nous a inspire une methode alternative pour cibler et stabiliser une orbite periodique quelconque dans un systeme chaotique. Le ciblage est en general combine aux methodes de controle pour stabiliser rapidement un cycle donne. En general, il faut connaitre la position et la stabilite du cycle en question. La nouvelle methode de ciblage que nous presentons ne demande pas de connaitre a priori la position et la stabilite des orbites periodiques. Elle pourrait etre un outil complementaire aux methodes de ciblage et de controle actuelles.

  1. Computer-Assisted Integration of Knowledge in the Context of Identification of the Causes of Defects in Castings

    Directory of Open Access Journals (Sweden)

    Kluska-Nawarecka S.

    2014-06-01

    Full Text Available W pracy naszkicowano zasady tworzenia scenariuszy działań diagnostycznych przy określeniu przyczyn powstawania wad odlewów. Przedstawiono zasady działania informatycznego systemu integracji danych opartego na zastosowaniu technologii Extract-Trasform-Load, oraz opis prototypowej realizacji tego systemu, a także przykłady przeprowadzonych testów.

  2. Prikazi koplja te luka i strijele na srednjovjekovnim nadgrobnim spomenicima iz Dalmatinske Zagore

    OpenAIRE

    Kužić, Krešimir

    2002-01-01

    Autor opisuje reljefne prikaze kopalja i lukova sa strijelama na kamicima iz Dalmatinske zagore. Nakon uvodne tipološke obrade oružjâ, navodi se latinsko i hrvatsko nazivlje za pojedine podvrste kopalja i lukova. Zatim slijedi opis i iz toga izvedena datacija prikaza dvaju kopalja i dvaju lukova sa strijelama na srednjovjekovnim nadgrobnim spomenicima. U zaključnom dijelu rada naveden je razlog odbacivanja tih oružja.

  3. TEHNOLOGIJE 3D TISKALNIKOV

    OpenAIRE

    Kolar, Nataša

    2016-01-01

    Diplomsko delo predstavi razvoj tiskanja skozi čas. Podrobneje so opisani 3D tiskalniki, ki uporabljajo različne tehnologije 3D tiskanja. Predstavljene so različne tehnologije 3D tiskanja, njihova uporaba in narejeni prototipi oz. končni izdelki. Diplomsko delo opiše celoten postopek, od zamisli, priprave podatkov in tiskalnika do izdelave prototipa oz. končnega izdelka.

  4. Electron Microscopy to Correlate Cell Structure and Biochemical Activity

    Science.gov (United States)

    1993-03-10

    Plasmodium coatneyi-infected rhesus monkeys: a primate model for human cerebral malaria. Memorias do Instituto Osvald Cruz (In Press). 24. Sim, K.L...P. coatney1 and found th.’t cvtoadherence of PRBC to ei.dothelial cells is a consistent feature of infections with this primate parasite. Cerebral ...Malaria; iaraunoe loct ror.-micros.’opy ; Chemotherapy; DFO; Cerebral malaria; HA 1 17 SECURITY CLASSIFICATION Of REPORT Unclass1 fled 1

  5. On a Fully Nonlinear Parabolic Equation and the Asymptotic Behaviour of its Solutions

    Science.gov (United States)

    1981-10-01

    and Universidad Complutense de Madrid , SPAIN " Sponsored by the United States Army under Contract No flAAG29-80-C-0041. l opy VNSPECrc>/ A2...weakly in H (Q), when t + ¶, to a function 0 * Universidad de Santander and Universidad Complutense de Madrid , SPAIN Sponsored hy the United States Army...variational inequality ’i accretive operator, asymptotic behaviour / . ~, 4, Work Unit Number 1 (Applied Analysis) " / . / " *• Universidad de Santander

  6. STANDARDI TRAJNOSTNE ARHITEKTURE : ZELENA STREHA

    OpenAIRE

    Kerin, Helenca

    2010-01-01

    Zelene strehe predstavljajo neizkoriščen potencial, s katerim lahko naravi povrnemo odvzete zelene površine zaradi gradnje in s tem dvignemo nivo kvalitete bivanja. Diplomsko delo obravnava zeleno streho kot arhitekturni element, ki s svojimi lastnostmi predstavlja standard trajnostne arhitekture. Podan je splošen opis razvoja zelene strehe skozi zgodovino ter vloga zelene strehe v urbanem okolju. Predstavljene so osnovne značilnosti zelene strehe ter opisani posamezni sestavi. V nadalje...

  7. Characterization of Surface Film Growth During Electrochemical Process: Nickel/Nickel Alloys in Seawater

    Science.gov (United States)

    2006-11-01

    of the structure of nickel electrodes during hydrogen evolution in sulfuric acid electrolysis. Those investigators reported that by x-ray diffraction...to a constant potential of - 500 mV, respectively. The diffraction patterns were analyzed. It was found that, apart from the initial hydrogen gas...Acual XPS sOWr c 4C opy+ MOf acWualXpS spectagenertedby cuvefztthW DP -_4 D.COIWohI•MIpeaksof thwcurvefitted XPS spectra Figure 73. Nickel peaks

  8. Ergonomsko oblikovanje delovnega mesta s pomočjo računalniških simulacij

    OpenAIRE

    Hribernik, Blaž

    2016-01-01

    V diplomskem delu ergonomsko oblikovanje delovnega mesta je predstavljena ergonomska analiza montaže sestava zaslonke. V uvodnem delu je predstavljen namen ergonomije in njen pomen, ergonomska metoda OWAS, RULA in podjetje HSS. Osrednji del diplomske naloge predstavlja opis delovnega mesta in oceno kontrole z vidika ergonomskih načel, ročni preračun ergonomske metode OWAS in analizo delovnega mesta z uporabo programskega paketa Human simulation Jack. Zaključni del diplome pa predstavlja rezu...

  9. La pena de muerte en la Convención Americana sobre Derechos Humanos y en la jurisprudencia de la Corte Interamericana

    OpenAIRE

    Sergio García Ramírez

    2005-01-01

    En el presente artículo, el autor, a través del estudio de la Convención Americana sobre Derechos Humanos y la jurisprudencia de la Corte Interamericana y otros instrumentos internacionales sobre derechos humanos, discute los criterios y decisiones más importantes adoptadas por la Corte Interamericana de Derechos Humanos sobre la pena de muerte. El estudio de los diversos convenios, convenciones, tratados y jurisprudencia internacional, permite conocer el alcance y aplicabilidad de nuevas opi...

  10. Los sectores institucionales en la producción científica española de difusión internacional

    OpenAIRE

    González–Albo, Borja; Aparicio, Javier; Moreno, Luz; Bordons, María

    2016-01-01

    Institutional sectors —groups of centers with similar characteristics and types of R&D— constitute an interesting unit of analysis that can also serve as a useful framework for benchmarking purposes in R&D studies. The analysis of Spanish scientific output included in the Web of Science database (2000–2011) shows the predominance of Universities (66%), followed by the Public Research Organisations (OPI) (23%) and the Health Sector (18%). Non–profit organizations (ESAL) (10%), which include bo...

  11. O liturgijskom ruhu u fundusu Gradskog muzeja Varaždin

    OpenAIRE

    Mesek, Ariana

    2012-01-01

    U ovome radu autorica donosi pregled razvoja i mijene oblika liturgijskog ruha kroz povijest, simboliku liturgijskih boja, govori o svilenim tkaninama u liturgiji te osnovnim uzrocima njihova propadanja. Nadalje, daje pregled razvoja tekstilne proizvodnje i dekorativne motivike od samih početaka proizvodnje na europskom tlu. Na pregledan način donosi tipologiju motiva prisutnih na tkaninama od kojih je izrađeno liturgijsko ruho koje se nalazi u fundusu Gradskog muzeja Varaždin uz opis svakog ...

  12. Models of a Service System for Production Machine Maintenance

    Science.gov (United States)

    1983-11-01

    Craighead DRSMC-SA (R)/Mr. B. Witherspoon DRSMC-SAS (R)/Mr. D. Eckman Mr. F. Northey Mr, J. Wasson DRSMC-SAL (R)/Mr. N. Trier DRSMC-SAA (R...Mr. B. White DRSMC-OPP (R)/Mr. P. Woodhouse DRSMC-OPI (R)/Mr. R. Heider DRSMC-LEP-L (R)/Ms. Sandi Paul Chief Benet Weapons Lab, LCWCL

  13. Methods for Choosing Buffer Size in Tandem Production Operations

    Science.gov (United States)

    1983-08-01

    DRSMC Craig Colledge -IRP George Cowan -IRD Mohan Devaraju -IRI-M Bob Gunnare -IRI Jim Kilar -IRI Matt Craighead -PP Don Eckman -6AS Fred...Northey -SAS Jim Wasson -SAS Herman Michels -SAL Norm Trier -SAL Byron White -SAA Don Wahlgren -ASM Brian Walters -ASA Dennis Winegar -LEM Paul ...Woodhouse -OPP Dick Heider -OPI Sandi Paul -LEP-L 39 ANNEXES COMPUTER SOURCE PROGRAMS The program listings in these annexes are written in

  14. VARNOSTNA TVEGANJA PRI RAZVOJU INFORMACIJSKIH REŠITEV S POMOČJO SISTEMOV ZA UPRAVLJANJE VSEBIN

    OpenAIRE

    Leskovar, Uroš

    2015-01-01

    V diplomskem delu je obravnavana problematika varnostnih tveganj pri razvoju in uporabi informacijskih rešitev kadar uporabljamo sisteme za upravljanje vsebin. Varnost v informacijskih sistemih je pogosto ogrožena, kljub vedno novejšim tehnologijam. Diplomsko delo zajema splošen opis treh najpogostejših sistemov za upravljanje vsebin, primerjavo preteklih testiranj sistemov, varnostno testiranje s pomočjo navodil drugih organizacij in pregled najpogostejših nevarnosti. Ugotovljeno je bilo, da...

  15. Fourth Aircraft Interior Noise Workshop

    Science.gov (United States)

    1992-07-01

    OPi »0Pi 60 I !J:-»*C Predicted pressure fifld or ik- Irf’.K’id c :.• o’":,•.• S: •"• r’V" different unc weps KU • Scheme of computation...I--: MODEL VALIDATION AKALTSIS I 4 Acoustic Mockup shaker test simulation * 16 shakers with simultaneously sinusodial force ( 95 Hz

  16. Kazenskopravni vidiki zdravniške evtanazije : diplomsko delo visokošolskega strokovnega študija Varnost in policijsko delo

    OpenAIRE

    Kastelic, Stina

    2013-01-01

    V diplomski nalogi so opredeljene razlike med usmrtitvami s strani zdravnikov ter zdravniško evtanazijo. Odgovarjamo tudi na vprašanje, ali lahko pacient v skladu z veljavno slovensko zakonodajo veljavno privoli v to, da ga nekdo usmrti. V diplomski nalogi je opisan pojem evtanazije, predstavljena je njena zgodovina oziroma razvoj in razumevanje evtanazije vse od antičnih časov dalje. Predstavljene so tudi vrste evtanazije in njihov opis, razlika med posrednim in neposrednim ravnanjem ter pal...

  17. AcEST: DK961339 [AcEST

    Lifescience Database Archive (English)

    Full Text Available r|B8XXI2|B8XXI2_ANNCH Expansin OS=Annona cherimola GN=Exp3 PE=2... 88 2e-16 tr|A4GV02|A4GV02_CALPC Alpha expansin protein 3 OS=Calotr...opis pr... 88 2e-16 tr|Q9ZP39|Q9ZP39_TOBAC Alpha-expansin OS=Nicotiana tabacum GN=N

  18. Integral Manifolds of Slow Adaptation.

    Science.gov (United States)

    1986-08-01

    1984 :Av-I.,,’L n,>/or iDist Pecelnl THESIS Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in...UNCLASSIFIED F/G 9/3 NUL E17hhhhh EhhhhhhhhhEl Jll MViCR(,,(’OPY RESOLUTION TESI % . ’ "v" ," " ,# ’% = 1111 .0 U ’"’ %%’ ’%=U 2 8 " "" , 89 following

  19. Identification of Random Amplified Polymorphic DNA Markers Linked to the Co-4 Resistance Gene to Colletotrichum lindemuthianum in Common Bean.

    Science.gov (United States)

    de Arruda, M C; Alzate-Marin, A L; Chagas, J M; Moreira, M A; de Barros, E G

    2000-07-01

    ABSTRACT New cultivars of the common bean (Phaseolus vulgaris) with durable resistance to anthracnose can be developed by pyramiding major resistance genes using marker-assisted selection. To this end, it is necessary to identify sources of resistance and molecular markers tightly linked to the resistance genes. The objectives of this work were to study the inheritance of resistance to anthracnose in the cultivar TO (carrying the Co-4 gene), to identify random amplified polymorphic DNA (RAPD) markers linked to Co-4, and to introgress this gene in the cultivar Rudá. Populations F(1), F(2), F(2:3), BC(1)s, and BC(1)r from the cross Rudá x TO were inoculated with race 65 of Colletotrichum lindemuthianum, causal agent of bean anthracnose. The phenotypic ratios (resistant/susceptible) were 3:1 in the F(2) population, 1:1 in the BC(1)s, and 1:0 in the BC(1)r, confirming that resistance to anthracnose in the cultivar TO was monogenic and dominant. Six RAPD markers linked to the Co-4 gene were identified, four in the coupling phase: OPY20(830C) (0.0 centimorgan [cM]), OPC08(900C) (9.7 cM), OPI16(850C) (14.3 cM), and OPJ01(1,380C) (18.1 cM); and two in the repulsion phase: OPB03(1,800T) (3.7 cM) and OPA18(830T) (17.4 cM). OPY20(830C) and OPB03(1,800T), used in association as a codominant pair, allowed the identification of the three genotypic classes with a high degree of confidence. Marker OPY20(830C), which is tightly linked to Co-4, is being used to assist in breeding for resistance to anthracnose.

  20. Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Feddersen, Søren; Neergaard, Thomas B F; Knudsen, Jens;

    2007-01-01

    proteins involved in fatty acid and phospholipid synthesis (e.g. FAS1, FAS2, ACC1, OLE1, INO1 and OPI3), glycolysis and glycerol metabolism (e.g. GPD1 and TDH1), ion transport and uptake (e.g. ITR1 and HNM1) and stress response (e.g. HSP12, DDR2 and CTT1). In the present study, we show that transcription...

  1. Diffuse reflectance spectroscopy and optical polarization imaging of in-vivo biological tissue

    Science.gov (United States)

    Mora-Núñez, A.; Castillejos, Y.; García-Torales, G.; Martínez-Ponce, G.

    2013-11-01

    A number of optical techniques have been reported in the scientific literature as accomplishable methodologies to diagnose diseases in biological tissue, for instance, diffuse reflectance spectroscopy (DRS) and optical polarization imaging (OPI). The skin is the largest organ in the body and consists of three primary layers, namely, the epidermis (the outermost layer exposed to the world), the dermis, and the hypodermis. The epidermis changes from to site to site, mainly because of difference in hydration. A lower water content increase light scattering and reduce the penetration depth of radiation. In this work, two hairless mice have been selected to evaluate their skin features by using DRS and OPI. Four areas of the specimen body were chosen to realize the comparison: back, abdomen, tail, and head. From DRS, it was possible to distinguish the skin nature because of different blood irrigation at dermis. In the other hand, OPI shows pseudo-depolarizing regions in the measured Mueller images related to a spatially varying propagation of the scattered light. This provides information about the cell size in the irradiated skin.

  2. Improvement of photocatalytic activity of silver nanoparticles by radio frequency oxygen plasma irradiation

    Science.gov (United States)

    Fang, Yingcui; Zhang, Bing; Hong, Liu; Yao, Damao; Xie, Zhiqiang; Jiang, Yang

    2015-07-01

    Photocatalytic activity (PA) of silver nanoparticles (AgNPs) induced by radio frequency (RF) oxygen plasma irradiation (OPI) is investigated in this paper. An improvement in PA by 365% and 181% has been achieved when 15 nm AgNPs irradiated by oxygen plasma for 2 s were used to degrade 10-5 M Rhodamine 6 G (R6G) under ultraviolet (UV) and visible lights, respectively. The PA caused by OPI is better than that induced by the localized surface plasma resonance (LSPR) of AgNPs. The mechanism for the improvement was explored by scanning electron microscopy (SEM), x-ray photoelectron spectroscopy (XPS) and UV-vis absorption spectra. The OPI-induced formation of AgO/AgNP and Ag2O/AgNP-heterogeneous photocatalysts and electrophilic oxygen are considered to be responsible for the PA improvement. This investigation deepens our understanding of oxygen-assisted photocatalysis of AgNPs and provides a practical approach using solar light for broad spectra photocatalysis with high efficiency.

  3. Estudo cefalométrico individualizado do posicionamento da maxila em indivíduos com equilíbrio facial e oclusão normal Individual cephalometric study of the position of the maxilla in subjects with good facial balance and normal occlusion

    Directory of Open Access Journals (Sweden)

    Fernando Penteado Lopes da Silva

    2008-12-01

    Full Text Available INTRODUÇÃO: o posicionamento da maxila no esqueleto craniofacial tem sido motivo de investigação por diversos autores. Traduzindo suas idéias por meio de medidas lineares ou angulares, tais autores definiram o que consideraram como a posição "ideal", "normal" e, ainda, "aceitável" ou "inaceitável" da maxila, relacionando-a, na maioria das vezes, com a base do crânio. A partir da avaliação de indivíduos com oclusão considerada normal e com bom equilíbrio facial, eram calculados valores médios e desvios-padrão de determinadas medidas, os quais eram tomados como parâmetros para avaliações cefalométricas de pacientes distintos. OBJETIVOS: diante das divergências de opiniões encontradas na literatura, a proposta do presente estudo foi avaliar o posicionamento da maxila nos sentidos vertical e ântero-posterior, além da sua inclinação, numa amostra de 94 indivíduos com oclusão normal e equilíbrio facial. MÉTODOS: foram determinadas correlações entre medidas do próprio indivíduo: OPI-N com OPI-ENA e N-ENA com ENA-ENP. CONCLUSÕES: a partir dos fortes índices de correlação encontrados, concluiu-se que a medida OPI-N pode ser tomada como referência para determinação de OPI-ENA, da mesma forma que ENA-ENP pode ser considerada para determinação de N-ENA, definindo, respectivamente, a posição da maxila nos sentidos sagital e vertical. A inclinação da maxila, representada aqui pelo ângulo OPI.ENA.ENP, teve valor médio estatisticamente próximo a 0º (zero grau, indicando forte tendência do prolongamento posterior do plano palatino (ENA-ENP tangenciar a base posterior do crânio (ponto OPI, o que se revela como uma importante característica de indivíduos com oclusão normal e equilíbrio facial.INTRODUCTION: The position of the maxilla in the skull is subject of investigation by many authors. Transmitting their ideas trough linear and angular measurements, they defined what is considered as "ideal", "normal

  4. ADMINISTRAÇÃO EPIDURAL DE OPIÓIDES EM CÃES EPIDURAL OPIOIDS ADMINISTRATION IN DOGS

    Directory of Open Access Journals (Sweden)

    Carlos Augusto Araújo Valadão

    2002-04-01

    Full Text Available Os opióides têm sido utilizados em Medicina Veterinária há vários anos como alternativa para o alívio da dor pós-operatória ou traumática. Atualmente, tem-se dado maior valor ao controle da dor nos animais, visando a oferecer melhores condições de recuperação ao paciente traumatizado ou recém-operado. A morfina foi o primeiro opióide usado em animais. Mais recentemente, a administração dessa substância, por via epidural, vem sendo empregada no controle da dor com resultados promissores. Assim, nesta revisão, abordam-se vários aspectos referentes aos efeitos e às indicações da administração epidural de opióides em cães.Opioids have been used for several years to relieve traumatic pain in Veterinary Medicine. The painful stimulus are implicated with delayed tissue recuperation of surgical wounds. Today, a great importance has been given to pre-emptive control of post operative pain in animals. Indeed, the use of epidural morphine, the first opioid substance used in animals, has provided excellent analgesia and good condition at the immediate post operative period. In addition, several aspects concerning the effects indications and forms of epidural opioids injections in dogs are considered in this review.

  5. Disorder effects in cuprates

    Science.gov (United States)

    Vobornik, I.; Grioni, M.; Berger, Helmuth; Forro, Laszlo; Pavuna, Davor; Margaritondo, Giorgio; Karkin, A.; Kelley, Ronald J.; Onellion, Marshall

    2000-09-01

    We report on ab-plane resistivity ((rho) ) and angle-resolved photoemission (ARPES) spectra for Bi2Sr2CaCu2O8+x single crystals irradiated with neutrons or electron-beam irradiation. Both the normal and superconducting states were measured with angle-resolved photoemission. Electron-beam irradiation leads to an increase in the residual resistivity, and a decrease in the superconducting transition temperature (Tc). The resistivity data does not indicate any pseudogap; the resistivity is linear from Tc to 300 K for all levels of disorder, and the slope (d(rho) /dT) is the same for all levels of disorder. The superconducting state ARPES data exhibits no change in the binding energy of the 'peak' for Brillouin zone locations near the (O,(pi) ) point. The peak spectral intensity decreases with increasing disorder, the gap fills in, but the peak neither shifts nor broadens. The normal state exhibits a pseudogap developing with disorder; the size of the pseudogap increases as the residual resistivity increases. The pseudogap is anisotropic, largest near the (O,(pi) ) point and zero in the direction. Neutron-beam irradiation causes an increase in the residual resistivity. The resistivity data exhibit a change of slope and indications of a pseudogap for neutron irradiation. For normal state ARPES data of neutron-beam irradiated samples, there is also an anisotropic pseudogap; it is also zero in the direction and large near the (O,(pi) ) point. We discuss implications of these data.

  6. Growth of Thin, Anisotropic, π-Conjugated Molecular Films by Step-Wise `Click' Assembly of Molecular Building Blocks: Characterizing Reaction Yield, Surface Coverage, and Film Thickness vs. Addition Step Number

    Science.gov (United States)

    Demissie, Abel; Haugstad, Greg; Frisbie, C. Daniel

    2015-03-01

    Molecular electronics is an active field of nanotechnology that has gained much interest due to the advent of modern microscopy techniques, and thin film synthesis using click chemistry - an approach which has enabled scientists to achieve a sub-angstrom control of monolayer length. Among the major challenges to grow oriented, surface-confined wires by click chemistry is development of synthetic routes that yield monodisperse wires, and lack of systematic way to measure the surface coverage of molecules. In this work, we report a comprehensive characterization of π-conjugated oligophenylene imine (OPI) wires synthesized step-wise by imine condensation click chemistry. OPI wire synthesis began with a self-assembled monolayer (SAM) of 4-formylthiophenol or 4-aminothiophenol on Au, followed by alternate addition of terepthaldehyde or phenylenediamine. OPI wires were characterized after each monomer addition via Rutherford backscattering spectrometry, x-ray photoelectron spectroscopy, cyclic voltammetry, reflection-absorption infra-red spectroscopy, and nuclear reaction analysis. We have determined an average extent of reaction greater than 98% completion for each growth step using five different techniques. Overall, these nanoscale scale surface characterization techniques proved to be an extremely sufficient method for monitoring wire growth and surface coverage.

  7. Description of a novel viral tool to identify and quantify ovine faecal pollution in the environment.

    Science.gov (United States)

    Rusiñol, Marta; Carratalà, Anna; Hundesa, Ayalkibet; Bach, Alex; Kern, Anita; Vantarakis, Apostolos; Girones, Rosina; Bofill-Mas, Sílvia

    2013-08-01

    Farmed animals such as sheep, cattle, swine and poultry play an important role in microbial contamination of water, crops and food, and introduce large quantities of pathogens into the environment. The ability to determine the origin of faecal pollution in water resources is essential when establishing a robust and efficient water management system. Animal-specific viruses have previously been suggested as microbial source tracking tools, but specific ovine viral markers have not been reported before now. Previous studies have shown that polyomaviruses are host-specific, highly prevalent and are commonly excreted in urine. Furthermore, they have been reported to infect several vertebrate species but not sheep. That situation encouraged the study of a new putative ovine polyomavirus (OPyV) and its use to determine whether faecal pollution originates from ovine faecal/urine contamination. Putative OPyV DNA was amplified from ovine urine and faecal samples using a broad-spectrum nested PCR (nPCR). Specific nested PCR and quantitative PCR assays were developed and applied to faecal and environmental samples, including sheep slurries, slaughterhouse wastewater effluents, urban sewage and river water samples. Successful amplification by PCR was achieved in sheep urine samples, sheep slaughterhouse wastewater and downstream sewage effluents. The assay was specific and was negative in samples of human, bovine, goat, swine and chicken origin. Ovine faecal pollution was detected in river water samples by applying the designed methods. These results provide a quantitative tool for the analysis of OPyV as a suitable viral indicator of sheep faecal contamination that may be present in the environment.

  8. Pobreza, movimiento social y mujer

    Directory of Open Access Journals (Sweden)

    Elsa Patiño Tovar

    2005-01-01

    Full Text Available Los movimientos sociales en Puebla se han nutrido ampliamente de la participación de las mujeres; sobre todo, cuando hablamos de las organizaciones populares independientes (OPI. Su participación ha mantenido vivas a muchas organizaciones que de otra manera habrían desaparecido ya, pues no sólo participan en las tareas cotidianas de la organización sino, también, son las primeras en dar la cara cuando hay enfrentamientos con el gobierno y sus organizaciones corporativas, en donde han repelido agresiones incluso violentas. Sin embargo, a pesar de que las OPI se compongan en 90% por mujeres, sus líderes son hombres y ellas son base, no dirigencia. El machismo se mantiene en la mentalidad de ellos… y de ellas, que aceptan que sean los hombres quienes tomen las riendas, porque ellas se sienten inseguras para encabezar a la organización y, además, las tareas del hogar tampoco se los permiten. La lucha de la mujer por sus derechos ha tenido un fuerte impacto internacional, pero tal parece que en las OPI de Puebla este proceso no ha logrado penetrar lo suficiente como para romper los propios límites que se ha impuesto la mujer por una larga tradición que la atrapa en su papel de esposa y ama de casa. En este artículo nos interesa explorar las razones por las que la participación en los movimientos sociales ha permitido que la mujer comprenda su situación, pero no la ha inducido a modificarla.

  9. Developement of a large proton accelerator for innovative researches; development of low energy high current beam transport system

    Energy Technology Data Exchange (ETDEWEB)

    Ko, In Soo; Namkung, Won; Cho, M. H.; Kim, K. N.; Kim, J. H.; Bae, Y. S.; Kim, Y.; Kim, K. H.; Shim, K. Y. [Pohang University of Science and Technology, Pohang (Korea)

    2001-04-01

    We have designed the beam transport system to connect the ion source and the RFQ. In this design, we have finalized the positions of solenoids and various beam diagnostic device. We have finalize the physical and mechanical designs of solenoids, and these designs are already adopted to produce the actual solenoids. We have also studied about EPICS, Experimental Physics and Industrial Control System, to control a stepper motor as a tuner of the RFQ designed for KOMACEPICS is a real time control system for a large scale system such as accelerators and tokamaks. The purpose of this thesis is to establish a test system based on the EPICS. A Sun UtraSPARC 5 workstation is used as the Operator Interface(OPI) console, and a VME chassis contained a Motorola MVME162 single board computer is used as the Input/Output Controller(IOC). A stepper motor controller is connected to the IOC via an RS-232C as a field bus. The EPICS base, extensions, and the real time OS vxWorks are installed on the workstation. The real time OS image can be downloaded to the IOC via the FTP when the test station is started. We have installed an IOC application as a device and driver support layer for the serial communication with an RS-232C on the workstation. We have designed the IOC database configuration files and a graphic user interface style OPI panel which was programmed by the MEDM. With this OPI, we can control the stepper motor using EPICS. 17 refs., 33 figs., 9 tabs. (Author)

  10. Rapid Epidemiological Assessment of Onchocerciasis in a Tropical Semi-Urban Community, Enugu State, Nigeria

    Directory of Open Access Journals (Sweden)

    JE Eyo

    2013-03-01

    Full Text Available Background: This study was carried out in Opi-Agu a tropical semi-urban autonomous community comprising of three villages in Enugu State, Nigeria, between the months of April and June 2010. It was designed to determine the prevalence of Onchocerca volvulus infection and assess the perception of the disease among the inhabitants of this community.Methods: A total number of 305 individuals comprising of 148 males and 157 females were ex­amined for various manifestations of onchocerciasis symptoms using rapid epidemiological assess­ment (REA method.Results: Out of this number, 119 (39.02% individuals were infected. Prevalence of infection among age groups and villages varied. Age group 41 yr and above had the highest (31.00% prevalence, while among the villages, Ogbozalla village ranked higher (45.71% than the other villages. Overall the prevalence of infection among the sexes revealed that males were more infected (43.24% than the females (35.03%. Lichenified onchodermatitis (LOD was the most prevalent (35.29% onchocercia­sis symptom among others identified in the area, while leopard skin (LS had the lowest (20.17% occurrence and blindness (0.00% which is the most devastating effect of O. volvulus infec­tion was not observed. Questionnaire responses from 410 individuals revealed that 34.8% respon­dent from Idi village and 28.1% from Ibeku village believed that O. volvulus infection occurs through poor personal hygiene. Bite of blackfly ranked least (10.6% among the respondent’s knowledge of the causes of onchocerciasis in Opi-Agu community.Conclusion: Opi-Agu community members had poor knowledge of onchocerciasis, the vector and of its etiologic organism. There is need for integration of community health education with mass chemo­therapy

  11. The effects of different pre-game motivational interventions on athlete free hormonal state and subsequent performance in professional rugby union matches.

    Science.gov (United States)

    Cook, Christian J; Crewther, Blair T

    2012-07-16

    We examined the effect of different pre-match motivational interventions on athlete free testosterone (T) and cortisol (C) concentrations and subsequent match performance in professional rugby union. Male participants (n=12) playing at a senior or academy level in rugby union were recruited and each completed three interventions (15 min each) before a competitive game; 1) watching a video clip of successful skill execution by the player with positive coach feedback [VPCF1]; 2) watching a video clip of successful skill execution by an opposing player with cautionary coach feedback [VCCF], 3) the player left alone to self-motivate [SM1]. The first and last interventions were retested [VPCF2 and SM2]. Salivary free T and C measures were taken pre-intervention and pre-game. Within each game, players were rated by coaching staff on a key performance indicator (KPI) from identified skills and an overall performance indicator (OPI), where 1 = best performance to 5 = worst performance. The VPCF1 and VPCF2 interventions both promoted significant T responses (11.8% to 12.5%) before each game and more so than SM1, SM2 and VCCF. The VCCF approach produced the largest C response (17.6%) and this differed from all other treatments. The VPCF interventions were also associated with better game KPI (1.5 to 1.8) and OPI ratings (1.7 to 1.8) than SM1, SM2 and/or VCCF. Across all treatments, greater individual T responses and lower C responses were associated with better KPI and OPI outcomes. In conclusion, the pre-game presentation of motivational strategies to athletes involving specific video footage and coach feedback produced different outcomes on two indicators of match performance, which were also associated with changes in free hormonal state. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Characterization of the porosity in TRISO coated fuel particles and its effect on the relative thermal diffusivity

    Energy Technology Data Exchange (ETDEWEB)

    Bari, Klaudio, E-mail: klaudiobari@icloud.com [School of Mechanical, Aerospace and Civil Engineering (MACE), University of Manchester, Pariser Building, Manchester M60 1QD (United Kingdom); Osarinmwian, Charles [School of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); López-Honorato, Eddie [Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav), Unidad Saltillo, Av. Industria Metalúrgica 1062, Ramos Arizpe, Coahuila 25900 (Mexico); Abram, Timothy J. [School of Mechanical, Aerospace and Civil Engineering (MACE), University of Manchester, Pariser Building, Manchester M60 1QD (United Kingdom)

    2013-12-15

    Highlights: • Identification of the porosity in 3D using Image Based Modelling (IBM). • The porosity volume fractions are varied 15.2–25.9 vol% in TRISO particles. • Comparison of IBM results with mercury intrusion and helium pycnometry. • The porosity in TRISO reduces the thermal diffusivity by factor 79–88%. • Open and closed pores can be identified using IBM. - Abstract: A heat transfer model for a Tri-structural Isotropic (TRISO) coated fuel particle was developed using Image Based Modelling (IBM). Computed X-ray tomography at a resolution of 0.7 μm was used to quantify the porosity of each layer. In order to study the thermal diffusivity of these coatings, an internal heat pulse was simulated in the kernel and the temperature, as a function of time, was measured from the surface of the Outer Pyrolitic Carbon (OPyC). Consequently, the half rise time of the temperature increase was found. The novel idea behind this technique is that once a heat pulse propagates through the particle layers, the half rise time of the temperature can be obtained from different spots on the OPyC surface. The article presents a correlation between the pore size distribution (measured by X-ray tomography) and the relative thermal diffusivity. The average porosities in OPyC (relative to the volume of the ceramic coating) measured using helium pycnometry, mercury intrusion porosimetry and X-ray tomography were 12.3 vol%, 9.0 vol% and 11.1 vol%, respectively.

  13. Famous Hyperboreans

    Directory of Open Access Journals (Sweden)

    Pär Sandin

    2014-11-01

    Full Text Available The individual Hyperboreans appearing in ancient literature are presented with a review of the Greek and Latin sources and collections of references. Most of the mythological characters are briefly discussed, but the literary evolution of the legends of Abaris and of the “Hyperborean maidens” are treated in some detail. Some of the literary sources receive scholarly treatment, the paper including philological notes on [Aristeas Epic.] fr. 11 Bernabé (the passage is inspired by an interpretation of the name Abaris; Call. Dian. 204–5 (includes an allusion to the Hyperborean maiden Upis/Opis; Call. Del. 293–95 (the passage hints at an etymology of the word Περφερέες; and ἐκεῖνοι in 295 is sound; Call. Aet. fr. 186.26–30 Pfeiffer (discussion of the myth of Orion and Opis; D.H. 1.43.1–2 (discussion of the myth of Palantho and Heracles; Hecat.Abd. FGrH 264 frr. 7, 12 (discussion of the different information about the Hyperborean leadership that is given in the two fragments; Hdt. 4.35 (interpretation of the phrase ἅμα αὐτοῖσι τοῖσι θεοῖσι; Iambl. VH 32.217 (the stated opinions of Abaris seem similar to those professed in Heraclid.Pont. fr. 75 Wehrli; Verg. Aen. 11.857–58 (the utterance of Opis alludes to the death of Orion as presented in Euphorion, Callimachus and pseudo-Apollodorus.

  14. Muzej krapinskih neandertalaca kao izvor medicinskih refleksija

    OpenAIRE

    Salopek, Igor

    2010-01-01

    Novootvoreni Muzej krapinskih neandertalaca s dvosegmentarnim postavom: prikazom karakteristika života krapinskog pračovjeka te suvremenih znanja o evoluciji života na Zemlji izvor je znanstvene, stručne i edukativne spoznaje posjetiteljima, kao i reprezent najbogatijeg nalazišta fosilnih ostataka neandertalaca u svijetu. U ovom radu ukratko je prikazan stručnoznanstveni posjet Muzeju članova Hrvatskoga znanstvenog društva za povijest zdravstvene kulture, ispreplećući pritom opis funkcije i p...

  15. Ophiuroidea das regiões antártica e subantártica: 1. sobre três espécies de Gorgonocephalidae e Ophiacanthidae Ophiuroidea from antarctic and subantarctic regions: 1. on three species of Gorgonocephalidae and Ophiacanthidae

    Directory of Open Access Journals (Sweden)

    Ana Maria Gouveia Monteiro

    1983-01-01

    Full Text Available É estudada a distribuição geográfica e a variação de caracteres morfológicos de três espécies de ofiuroides (OpiLacantha antartica, Astrotoma agassizzi e Gorgonecephalus chilensis das regiões Antártica e Subantãrtica. São também apresentadas observações sobre biologia reprodutiva.The geographical distribution and the variation of morphological characters of three (Gorgonecephalus chilensis, Astroma agassizii, Ophiacantha antartica from the Antarctic and Subantarctic regions are studied. Observations on reproductive biology are presented.

  16. ELEKTRIČNE LASTNOSTI HIDRIRANIH RAVNINSKIH LIPIDNIH DVOSLOJEV

    OpenAIRE

    Velikonja, Aljaž

    2014-01-01

    Osnovni gradnik membrane biološke celice je dvojna plast lipidnih molekul, pretežno sestavljena iz glicerofosfolipidov, proteinov ter drugih molekul. Čeprav je celična membrana nehomogena struktura, lahko nekatere njene osnovne fizikalne lastnosti dovolj dobro opišemo s študijem hidriranega ravninskega lipidnega dvosloja, sestavljenega izključno iz lipidnih molekul. Nekatere od teh lastnosti (npr. dolžina in nasičenost maščobnih verig) so odvisne tudi od temperature, zato se s temperaturo spr...

  17. Pancreatitis aguda necrotizante en una intoxicación fatal por metadona Acute necrotizing pancreatitis in a fatal poisoning with methadone

    OpenAIRE

    Sibón, A.; Ballesteros, S.; Martínez, M. C.

    2004-01-01

    La pancreatitis necrotizante es una causa infrecuente de muerte súbita. La metadona, un fármaco empleado en el tratamiento sustitutivo de adictos a opiáceos, ha sido responsable de muertes tras su ingestión accidental por niños cuando estaba a su alcance, en intentos autolíticos o después de un período de abstinencia en pacientes con tolerancia. La muerte se debe a depresión del sistema nervioso central y depresión respiratoria. Reportamos un caso de muerte súbita con pancreatitis aguda necro...

  18. Biliary acute pancreatitis: a review

    Institute of Scientific and Technical Information of China (English)

    Osvaldo M. Tiscomia; Susana Hamamura; Enriqueta S. de Lehmann; Graciela Otero; Hipólito Waisman; Patricia Tiscornia-Wasserman; Simmy Bank

    2000-01-01

    @@INTRODUCTION It is axiomatic that the most effective and soundly based plan of treatment of any disorder is one aimed at the mechanism or mechanisms responsible for its development[1]. This basic notion, coupled with recent reports[2- 11] in which, surprisingly there is a total lack of reference to the probable involvement of autonomic-arc-reflexes in the physiopathogenesis of biliary acute pancreatitis have prompted this presentation. Undoubtedly, this disease entity has numerous causes, an obscure physiopathology, few effective remedies, and, often, an unpredictable outcome. At the turn of the century, Opie[12,13] brought to light the association between gallstone migration and acute pancreatitis.

  19. Efeito analgésico da morfina e tramadol na artrite e sinovite induzidas experimentalmente em bovinos

    OpenAIRE

    Nogueira,Geison Morel

    2013-01-01

    Enfermidades que desenvolvem estímulos nociceptivos podais são frequentes na clínica de bovinos. O uso de analgésicos opióides, em ruminantes é limitado ou indefinido, como no caso do tramadol. Objetivou-se avaliar os efeitos analgésicos do sulfato de morfina e cloridrato de tramadol em bovinos, submetidos à artrite e sinovite interfalângica distal transitórias. Foram utilizados seis bovinos no protocolo de indução experimental de artrite e sinovite, através da administração intra-articular d...

  20. Whither Elite Cohesion in Mexico: A Comment

    Science.gov (United States)

    1988-11-01

    Generacicnes: Los Protagonistas de Ia Reforma y la Revoluci(n Mexicana, Secretaria de Educacion Pblica, Consejo Nacional de Fomento Educat ivo, Mexico City...t-, ~ ir;opy 000 WHITHER ELITE COHESION IN MEXICO : A COMMENT David Ronfeldt November 1988 DTIC ELECTEI Novo 6 la ... . ... ,D The RAND...Monica, CA 90406 21:8 WHITHER ELITE COHESION IN MEXICO : A COMMENT Pavii Ronfeldt Por dec:ies . .I(,xi -as had a ,henomena!!y cohr sive ruling e I ite non

  1. Protección miocárdica por el pre y el poscondicionamiento anestésico

    OpenAIRE

    Rubens Campana Pasqualin; José Otávio Costa Auler Jr

    2008-01-01

    JUSTIFICATIVA E OBJETIVO: A isquemia miocárdica perioperatória é um evento comumente observado no período perioperatório podendo aumentar significativamente a morbimortalidade pós-cirúrgica. As propriedades cardioprotetoras dos anestésicos voláteis e dos opióides têm sido estudadas durante algumas décadas e hoje constituem poderosas ferramentas no manuseio de pacientes com doença coronariana isquêmica. O objetivo desta revisão foi fornecer fundamentos da proteção miocárdica por precondicionam...

  2. Efeitos da naloxona, da metissergida e da fentolamina, por via subaracnóidea, sobre a modulação da dor, através do teste de formalina modificado, em ratos

    OpenAIRE

    Oscar César Pires

    2009-01-01

    Aferentes nociceptivos primários se projetam da periferia para o corno posterior da medula espinhal onde ativam grande número de neurônios de segunda ordem e de projeção. Há evidências de que a passagem de informações nociceptivas pelo CPME seguindo para níveis rostrais do sistema nervoso central, sofre profundas influências excitatórias e inibitórias. A presente pesquisa teve como objetivo comparar os efeitos dos antagonistas de opióides (naloxona), de serotonina (metissergida) e de noradren...

  3. Geometrija za analitike učenja

    OpenAIRE

    Divjak, Blaženka; Maretić, Marcel

    2016-01-01

    Analitike učenja usredotočene su na obrazovne izazove vezane uz postizanje svrsishodnog učenja. Vrednovanje postizanja ishoda učenja izrazito utječe na učenje. Međutim, podaci o procesu vrednovanja vrlo rijetko se koriste u postojećim analitikama učenja. Nadalje, postojeće implementacije i analize procesa istorazinskog (vršnjačkog) vrednovanja nisu zadovoljavajuće. Ovaj rad predstavlja izradu i upotrebu matematičkog modela za opis i računanje vezano uz istorazinsko vrednovanje. Razvijeni mode...

  4. Nadgradnja sporočilnega sistema na fakultetnih informacijskih sistemih

    OpenAIRE

    Farkaš, Aleš

    2015-01-01

    V diplomski nalogi podajam rešitev nadgradnje poštnih strežnikov nekaterih članic omrežja Univerze v Ljubljani. Prehod smo izvedli iz starega sporočilnega sistema Microsoft Exchange Server 2003 na Microsoft Exchange Server 2010. Poleg nadgradnje sporočilnih sistemov smo nadgradili tudi strežnike - nosilce aktivnega imenika na različico Windows Server 2008 R2. V prvem delu poleg splošnega pregleda strežnika Exchange in odjemalca Outlook opišemo še del omrežja Univerze ter podamo glavne l...

  5. Dexmedetomidina en pacientes pediátricos con requerimientos de ventilación mecánica y sus efectos sobre el síndrome de abstinencia

    OpenAIRE

    Rojas Cárdenas, Diana Emperatriz

    2009-01-01

    INTRODUCCION : Una de las prioridades del manejo en cuidado crítico pediátrico es la prevención y tratamiento del dolor y la ansiedad del paciente que requiere ventilación mecánica, utilizando diferentes alternativas farmacológicas, la más usada en pediatría es la basada en hipnosis que utiliza un opiáceo y una benzodiacepina , usualmente fentanyl y midazolam , pero con un riesgo reportado de producir síndrome de abstinencia cuando es usado de manera prolongada y su suspensión es abrupta1, si...

  6. Trabajadores agrícolas y subjetividad en California

    OpenAIRE

    Florencio Posadas Segura

    2014-01-01

    En este trabajo se explora el problema de la subjetividad de los trabajadores agríco - las, partiendo de la hipótesis de que éstos consideran malas sus condiciones de vida y de trabajo. Mediante el trabajo de campo se demostraron sus conocimientos y opi - niones sobre su situación laboral y existencial en el Valle de San Joaquín California durante 2007 y 2008. Se descubrió que la visión del trabajador agrícola está basada en la subjetivación y reinterpretación de sus circunstancias objetivas ...

  7. Uso do Tramadol no controle da tosse crônica : estudo N-DE-1 e revisão sistemática

    OpenAIRE

    Louly, Priscila Gebrim

    2008-01-01

    Este trabalho foi realizado a partir de um caso clínico em que uma paciente do Hospital Universitário de Brasília observou melhora da tosse crônica, secundária a uma pneumopatia intersticial, com o uso de tramadol 50 mg 12/12h, que havia sido prescrito para a dor. Esse fato fez com que a paciente utilizasse o tramadol continuamente. Não foram encontrados na literatura estudos clínicos que evidenciassem a atividade antitussígena do tramadol, um analgésico opióide. O presente trabalho utilizou ...

  8. VPLIV POLIELEKTROLITOV NA VSEBNOST SUHE SNOVI V ODPADNEM AKTIVNEM BLATU

    OpenAIRE

    Zrilić, Nika

    2015-01-01

    Magistrsko delo obravnava problematiko s področja čiščenja odpadnih voda, pri katerih uporabljamo konvencionalni postopek čiščenja z aktivnim blatom. Zajema opis odpadne vode, virov in njenih lastnosti ter predstavlja postopek čiščenja z aktivnim blatom, proces flokulacije in uporabo različnih polielektrolitov pri procesu dehidracije blata. V preliminarnih poskusih, ki smo jih izvedli na ČN Ptuj, smo s spreminjanjem pretoka na centrifugi preverili, kako omenjena sprememba vpliva na vsebnost s...

  9. Boat Tourists’ Perception of Environmental Problems : A Case Study in Estonian, Finnish and Swedish Archipelago

    OpenAIRE

    Palkeinen, Anne

    2013-01-01

    Tiivistelmä Meri- ja rannikkoalueiden turismi on yksi nopeimmin kasvavista turismin muodoista. Viimeisen kolmen vuosikymmenen aikana turismi merialueilla on lisääntynyt suuresti. Suuresta kasvusta huolimatta sen vaikutuksia on alettu laajemmin tutkia vasta viime vuosina. Tässä työssä tutkitaan vapaa-ajan veneilijöiden käsityksiä ympäristöongelmista Eestin, Suomen ja Ruotsin saaristossa. Tutkimuksessa käytetään strukturoituja kyselylomakkeita. Tutkimukseen osallistui 144 veneilijää. Opi...

  10. Ultrafast internal conversion of excited cytosine via the lowest pipi electronic singlet state.

    Science.gov (United States)

    Merchán, Manuela; Serrano-Andrés, Luis

    2003-07-09

    Computational evidence at the CASPT2 level supports that the lowest excited state pipi* contributes to the S1/S0 crossing responsible for the ultrafast decay of singlet excited cytosine. The computed radiative lifetime, 33 ns, is consistent with the experimentally derived value, 40 ns. The nOpi* state does not play a direct role in the rapid repopulation of the ground state; it is involved in a S2/S1 crossing. Alternative mechanisms through excited states pisigma* or nNpi* are not competitive in cytosine.

  11. Extraction, Purification and Characterization of Protease from Digestive Tract of Octopus vulgaris%章鱼消化道蛋白酶的分离纯化及性质

    Institute of Scientific and Technical Information of China (English)

    任佩; 王莹; 金玉兰; 朴美子

    2012-01-01

    以章鱼加工下脚料消化道为原料,经硫酸铵沉淀、纤维素CM-52阳离子交换层析、DEAE-SephadexA50阴离子交换层析、SDS-PAGE电泳等方法,从中提取纯化出一种蛋白酶电泳纯样品OP-I,并对其性质进行研究。结果表明:该酶分子质量为80.5kD。最适反应温度为55-60℃,pH值为7-9。金属蛋白酶抑制剂(EDTA)可以完全抑制该酶的活性。Mn^2+、Ca^2+、Mg^2+对OP-I有激活作用,酶促动力学研究显示其米氏常数量‰为0.33mmol/L,Vmax为66.7mg/(mL·min)。%An electrophoretically pure protease, named as OP-I, was obtained from the digestive tract of Octopus vulgaris by ammonium sulfate precipitation, cellulose CM-52 cation-exchange chromatography, DEAE-Sephadex A50 anion-exchange chromatography and SDS-PAGE. Its properties were also characterized. The results showed that the molecular weight of the protease was 80.5 kD and its optimal reaction temperature and pH were 55 - 60 ℃and 7 - 9, respectively. OP-I could be completely inhibited by EDTA, a metalloproteinase inhibitor. In contrast, Mn^2+, Ca^2+ and Mg^2+could stimulate OP-I activity. Moreover, the Km of OP-I was 0.33 mmol/L and Vmax was 66.7 mg/(mL · min)as determined by kinetic studies.

  12. Eficácia analgésica da dexmedetomidina comparada ao sufentanil em cirurgias intraperitoneais: estudo comparativo

    OpenAIRE

    Marangoni,Marco Aurélio; Castiglia, Yara Marcondes Machado [UNESP; Medeiros,Tiago Pechutti

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: A dexmedetomidina, agonista alfa2-adrenérgico com especificidade alfa1:alfa2 1:1620, não determina depressão respiratória, sendo utilizada no intra-operatório como sedativo e analgésico. Esse fármaco tem sido empregado com os opióides em anestesia de procedimentos com elevado estímulo doloroso, como os abdominais intraperitoneais, não havendo referências sobre seu uso como analgésico único. Comparou-se a dexmedetomidina ao sufentanil em procedimentos intraperitoneai...

  13. Mathematical Model and Simulator of Rotor With Vibrating Blades Model / Matematyczny I Symulator Stopnia Wirnikowego Z Drgającymi Łopatkami

    Directory of Open Access Journals (Sweden)

    Wachłaczenko Michał

    2014-12-01

    Full Text Available Tematem publikacji jest opis modelu matematycznego ułopatkowanej tarczy stopnia wirującego silnika odrzutowego. Poprawnie stworzony model matematyczny wirnika pozwala na stworzenie modelu symulacyjnego, który może posłużyć do generowania danych tip-timing. Przede wszystkim jest on potrzebny do badania odpowiedzi łopatek wieńca wirnikowego na wymuszenie w postaci zmian prędkości obrotowej silnika. Pozwala to na określenie warunków pracy silnika odrzutowego, dla których mogło by nastąpić jego uszkodzenie

  14. 急性有机磷农药中毒16例抢救临床分析

    Institute of Scientific and Technical Information of China (English)

    张新军; 孙振华

    2010-01-01

    @@ 急性有机磷农药中毒(acute organophosphorous insecticides poisoning,AOPP)是基层医院急诊常见病,因有机磷杀虫药(organophosphorous insecticides,OPI)毒性强,致死率高,所以抢救必须及时准确.武警新疆总队南疆指挥部医院自2004年至今抢救收治AOPP 16例,均成功救治,现报告如下.

  15. 有机磷杀虫药中毒

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    有机磷杀虫药(organophosphorous insecticides,OPI)中毒主要通过抑制体内胆碱酯酶(cholinesterase,ChE)活性,失去分解乙酰胆碱(acetylcholine,ACh)能力,引起体内生理效应部位ACh大量蓄积,使胆碱能神经持续过度兴奋,表现毒蕈碱样、烟碱样和中枢神经系统等中毒症状和体征.严重者常死于呼吸衰竭.

  16. RAZVOJ APLIKACIJ Z OGRODJEM OSGi

    OpenAIRE

    Blazin, Miha

    2011-01-01

    V diplomski nalogi opišemo, kako poteka razvoj aplikacij z ogrodjem OSGi. Glavne značilnost ogrodja so dinamičnost, modularnost in orientacija k storitvam. V praktičnem delu diplomske naloge izdelamo spletno aplikacijo, ki omogoča pogovor med uporabniki. Pri tem izdelamo večje število modulov OSGi, ki nam skupaj tvorijo končno aplikacijo. Za dostop do aplikacije izdelamo namizni, spletni, kakor tudi mobilni odjemalec. V zaključku diplomske naloge nato ugotovimo, kakšne prednosti nam prinaša r...

  17. SISTEM ZA NADZOR PROMETA IPTV

    OpenAIRE

    2013-01-01

    V diplomski nalogi bom predstavil sistem za nadzor prometa IPTV v telekomunikacijskem omrežju s pomočjo IPTV sond, ki nadzorujejo promet IPTV od dobavitelja signala pa vse do končnega uporabnika. V prvem delu sta opis in struktura elementov za delovanje IPTV, namenjenega za prenos signala od izvora do uporabnika storitev. Predstavljeni so standardi in mehanizmi stiskanja podatkov, pregled protokolov za prenos podatkov po omrežju ter elementi in arhitektura IPTV. V osrednjem delu naloge se bom...

  18. Novi pogledi na anatomiju grkljana dobrog dupina (Tursiops truncatus).

    OpenAIRE

    Brzica, Hrvoje; Špiranec, Katarina; Zečević, Iva; Lucić, Hrvoje; Gomerčić, Tomislav; Đuras, Martina

    2015-01-01

    Grkljan sisavaca je organ koji predstavlja zaštitu od ulaska hrane u dišni sustav, a većini sisavaca služi i za proizvodnju zvuka. Iako je općenita anatomija grkljana kitova odavno poznata, detalji su slabo proučavani što je za posljedicu imalo razne nedosljednosti u dostupnoj literaturi, pogotovo na temu prirode dorzalnih parnih hrskavica aritenoepiglotične cijevi i nabora sluznice u grkljanskoj šupljini. Cilj ovog rada je iznijeti potanki opis struktura grkljana dobrog dupina (Tursiops trun...

  19. Programas de mantenimiento de metadona con servicios auxiliares: un estudio de coste-efectividad

    OpenAIRE

    Puigdollers E.; Cots F; Brugal M.T.; Torralba L.; Domingo-Salvany A.

    2003-01-01

    Objetivo: Actualmente, los programas de mantenimiento con metadona (PMM) son la mejor alternativa de tratamiento para los adictos a opiáceos. Se pretende valorar el coste-efectividad de tres PMM que ofrecían diferentes servicios auxiliares utilizando como medida de efectividad el incremento de la calidad de vida. Métodos: Estudio de seguimiento a 12 meses de 586 pacientes que iniciaron tratamiento con metadona en los centros de atención y seguimiento municipales de Barcelona. Para medir la ev...

  20. Programas de mantenimiento de metadona con servicios auxiliares: un estudio de coste-efectividad Methadone maintenance programs with supplementary services: a cost-effectiveness study

    OpenAIRE

    E. Puigdollers; F. Cotsas; Brugal, M. T.; L. Torralba; Domingo-Salvany, A.

    2003-01-01

    Objetivo: Actualmente, los programas de mantenimiento con metadona (PMM) son la mejor alternativa de tratamiento para los adictos a opiáceos. Se pretende valorar el coste-efectividad de tres PMM que ofrecían diferentes servicios auxiliares utilizando como medida de efectividad el incremento de la calidad de vida. Métodos: Estudio de seguimiento a 12 meses de 586 pacientes que iniciaron tratamiento con metadona en los centros de atención y seguimiento municipales de Barcelona. Para medir la ev...

  1. First Record of Co – Infection of Three Clinostomatid Parasites in Cichlids (Osteichthyes: Cichlidae in a Tropical Freshwater Lake

    Directory of Open Access Journals (Sweden)

    GC Onyishi

    2012-07-01

    Full Text Available The present study investigated the effects of first record of co-infection of three Clinostomum sp.; Clinostomum Complanatum (Rudolphi, 1819, C. tilapiae (Ukoli, 1966, and Euclinostomum hetereostomum (1809 in Tilapia zilii. There was differential parasitic effects resulting in selection for relatively better adaptiveness to hosts microhabitats, more population size, and frequent host location of these parasites during the one year survey (Nov 2007- Oct 2008 in Opi Lake, Nigeria. Prevalence of 9.4 % was recorded in C. complanatum, 10.4 % in E. heterostomum and 4.8% in C. tilapiae. The parasites were recovered from three major microhabitats of buccal cavity, skin and eye.

  2. Statistics for the Maximum of Several Positive Random Variables with Application to Networking.

    Science.gov (United States)

    1984-12-01

    Witherspoon 1 AMSMC-OAA-S (R)/Mr. D. Eckman * 1 AMSMC-OAA-S (R)/Mr. G. Moeller 1AMSMC-OAA-L (R)/Mr. N. Trier 1AMSMC-OAA-A (R)/Mr. B. White 1 AMSMC-OPP (R)fMr...P. Woodhouse * 12 - DISTRIBUTION LIST (Cont’d) I No. of 1 AMSMC-OPI (R)/Mr. R. Heider 2 AMSMC-LEP-L (R)/Ms Sandi Paul 1 AMCPM-ADG-L (R)/Mr. J. Wasson

  3. System pomiaru koncentracji operatora maszyn i urządzeń górniczych

    Directory of Open Access Journals (Sweden)

    Jerzy Jagoda

    2017-04-01

    Full Text Available W artykule przedstawiono system zwiększający bezpieczeństwo pracy operatora maszyny i urządzeń w oparciu o pomiar poziomu koncentracji uwagi. Powstał on w odpowiedzi na wyniki analiz stanu bezpieczeństwa pracy WUG wskazujące, że najczęstszą przyczyną wypadków jest „niedostateczna koncentracja przy wykonywaniu pracy”. W artykule przedstawiono analizę rozwiązań rynkowych związanych z podjętą tematyką oraz opis proponowanego rozwiązania w postaci koncepcji systemu.

  4. Niveles plasmáticos de beta-endorfina en el ciclo menstrual y en la dismenorrea

    OpenAIRE

    2015-01-01

    Se realiza la valoración de las concentraciones plasmáticas de beta-endorfina en el ciclo menstrual y en la mujer dismenorreica, para lo que se estudian un grupo de jóvenes fértiles, todas ellas voluntarias, no estando ninguna sometida a tratamiento hormonal ni a anticoncepción. La sangre obtenida en días concretos del ciclo por punción venosa es analizada por RIA para obtener las concentraciones del opiáceo, determinándose las gonadotropinas y los esteroides ováricos por ELISA. La beta-endor...

  5. Uso do Tramadol no controle da tosse crônica : estudo N-DE-1 e revisão sistemática

    OpenAIRE

    Louly, Priscila Gebrim

    2008-01-01

    Este trabalho foi realizado a partir de um caso clínico em que uma paciente do Hospital Universitário de Brasília observou melhora da tosse crônica, secundária a uma pneumopatia intersticial, com o uso de tramadol 50 mg 12/12h, que havia sido prescrito para a dor. Esse fato fez com que a paciente utilizasse o tramadol continuamente. Não foram encontrados na literatura estudos clínicos que evidenciassem a atividade antitussígena do tramadol, um analgésico opióide. O presente trabalho utilizou ...

  6. MIKROKRMILNIŠKI SISTEM ZA MERJENJE TEMPERATURE IN RELATIVNE VLAŽNOSTI

    OpenAIRE

    Obojnik, Žiga

    2016-01-01

    V prvem delu diplomskega dela je na kratko predstavljena zgodovina merjenja temperature in temperaturne lestvice. Podrobneje so opisani ključni elektronski elementi, ki smo jih uporabil in sicer senzor za merjenje temperature in relativne vlažnosti SHT75, mikrokrmilnik PIC16f648a, štirivrstični zaslon LCD, napajalnik Traco Power ter programska oprema MikroC, Altium Designer in PICkit2. V zadnjem delu diplomskega dela je prikazana električna shema, 3D model vezja, izdelava tiskanine , opis de...

  7. KERTAKÄYTTÖISET SALASANAT TIETOVERKOISSA

    OpenAIRE

    Pienmunne, Juhamatti; Paulow, Jari

    2009-01-01

    Opinnäytetyössä tarkastellaan ja tutkitaan RSA SecurID -tuoteperhettä ja kertakäyttösalasanajärjestelmän toimintaa tietoliikennelaboratorio-olosuhteissa. RSA SecurID on julkiseen avaimeen perustuva salausjärjestelmä, jossa RSA SecurID -tokenien ja RSA SecurID -ohjelmiston välille luodaan turvattu yhteys. Toimeksiantajan pyynnöstä opinnäytetyössä keskityttiin järjestelmän asennukseen ja testaamiseen, jotta RSA SecurID:n toiminnasta saadaan riittävästi käytännön tietoa ja kokemusta. Opi...

  8. Implicación del sistema glutamatergico y del GHB en la adicción a la morfina y a la cocaína

    OpenAIRE

    Maldonado Adrián, Concepción

    2007-01-01

    RESUMEN El Objetivo general de la presente Tesis Doctoral fue el de estudiar la participación de la neurotransmisión glutamatérgica y del GHB en la adicción a los opiáceos y a la cocaína. En primer lugar hemos pretendido observar la contribución de estos dos sistemas de neurotransmisión en los efectos que la morfina presenta sobre las conductas sociales. Nuestra hipótesis fue que la afectación del sistema glutamatérgico, concretamente bloqueando los receptores NMDA (utilizando Memantina y ...

  9. A Phase Space Monitoring of Injected Beam of J-PARC MR

    Science.gov (United States)

    Hatakeyama, Shuichiro; Toyama, Takeshi

    Beam power of J-PARC MR (30 GeV Proton Synchrotron Main Ring) has been improved since 2008 and now achieved over 200 kW for the user operation. A part of beam loss is localized at the beam injection phase so it is important to monitor the beam bunch behavior in the transverse direction. In this paper it is described the method how to measure the position and momentum for each injected beam bunch using Beam Position Monitors (BPMs). It is also mentioned some implementation of an operator's interface (OPI) to display the plots of injected and circulating beam bunches in phase space coordinate.

  10. The Provincial Magnate Prohibiting Opium---TAO Shu%严禁鸦片的疆臣领袖--陶澍

    Institute of Scientific and Technical Information of China (English)

    陈蒲清

    2015-01-01

    TAO Shu’s opium ban,his prohibiting opium acts,and the repeated consultation of LIN Zexu to him,prove that TAO Shu was the first provincial magnate conducting large -scale destruction of opium,and was the political leader advocating prohibiting opi-um.%陶澍的禁烟主张、禁烟行动,以及林则徐禁烟反复征询陶澍意见,证明陶澍是最早大规模销毁鸦片的封疆大吏,是主张严禁鸦片的政坛领袖人物。

  11. One-way data transfer for PLC to VME status reporting at the Advanced Photon Source

    Science.gov (United States)

    Stein, S. J.

    1994-12-01

    The Personnel Safety System for the experimental beamlines at the Advanced Photon Source will use a large number of Allen Bradley Programmable Logic Controllers (PLC) to replace conventional relay logic. PLCs allow for the design of a very advanced safety system that can handle a large number of I/O points. Certain situations require monitoring of the safety system from various locations around the storage ring via the EPICS OPI (operator interface) consoles. This presentation covers the chosen method for transferring data from the Personnel Safety System into an EPICS database. Specifications on PLC ladder design, EPICS database design and hardware selection are also discussed.

  12. Eficacia y tolerabilidad de esteroides epidurales vs. Dosis bajas de esteroides mas metamizol mas D-propoxifeno administrados por vía paravertebral en pacientes con síndrome post-laminectomía Efficacy and tolerability of epidural steroids vs low doses of steroids plus metamizol plus propoxyphene administered paravertebrally for postaminectomy syndrome patients

    OpenAIRE

    J.A. Aldrete; U. Guevara; H. J. Arenoso; O. L. Ceraso

    2006-01-01

    El reconocimiento de la acción antinociceptiva de los antiinflamatorios no esteroideos (AINEs) ha motivado su combinación con dosis moderadas de opiáceos con objeto de obtener una mayor analgesia, mientras que se reduce la necesidad de emplear dosis altas de esteroides. Un grupo de 142 pacientes adultos, que habían desarrollaron radiculopatía y lumbalgia después de la primera discectomia, en los que se demostró radiologicamente fibrosis y cicatriz periradicular, en el sitio de operación, se d...

  13. PLESNI ODZIV PREDŠOLSKIH OTROK NA VIVALDIJEVO GLASBO

    OpenAIRE

    Vrhovnik, Natalija; Novak, Ksenija

    2014-01-01

    Diplomsko delo obravnava plesne dejavnosti otrok na predšolski stopnji. V teoretičnem delu so podane vsebine, ki izhajajo iz baroka oz. iz časa, v katerem je ustvarjal Antonio Vivaldi. Opisana je opredelitev umetnosti, dotaknemo se estetike ter otrokovih potreb po plesu. V drugem delu teoretičnega dela predstavimo življenjepis Antonia Vivaldija, obdobje, v katerem je živel, nato sledi opis njegovega dela Štirje letni časi. Namen empiričnega dela je bil preučiti plesni odziv otrok na ...

  14. Sraštenost prstiju uz istodobnu višestruku nerazvijenost mekuši na sve četiri noge sa sekundarnom kontrakturom duboke fleksorne tetive u šteneta.

    OpenAIRE

    Rodríguez-Alarcón, Carlos A.; Beristain-Ruiz, Diana M.; Itzá, Mateo F.; Rivera-Barreno, Ramón

    2014-01-01

    U radu je iznesen opis i procjena stanja u dvomjesečnog, 7 kg teškog šteneta, belgijskog Malinois ovčara, s jednostavnom i potpunom sraštenošću prstiju, nerazvijenim metakarpalnim/metatarzalnim mekušina na sve 4 noge te s kontrakturama duboke digitalne fleksorne tetive na lijevoj prednjoj i desnoj stražnjoj nozi. U slučaju prve lijeve noge obavljeno je presjecanje duboke digitalne fleksorne tetive (2. do 5. prsta) na razini gornje i srednje falange. Operacija stražnje noge nije obavljena jer ...

  15. SPREMLJANJE GRADNJE Z UPORABO RAZŠIRJENE RESNIČNOSTI (AUGMENTED REALITY) NA PRIMERU NASELJE KOLIŠČARJI

    OpenAIRE

    Kumalić, Emir

    2013-01-01

    Magistrsko delo obravnava opis ter uporabo nove tehnologije gradbene informatike v gradbenem sektorju, s poudarkom na »augmented reality« oz. na razširjeno resničnost. Predstavlja se uporaba 4D modeliranja objekta s povezavo mobilnih aplikacijskih programov, ki prikazuje razširjeno resničnost v naravi. V nalogi je bil izdelan digitalni 3D model zgodovinsko-arheološkega objekta naselje Koliščarji na Ljubljanskem barju, ki smo ga s pomočjo programa Navisworks Manager pretvorili v 4D model ter s...

  16. Pobreza, movimiento social y mujer

    OpenAIRE

    Elsa Patiño Tovar

    2005-01-01

    Los movimientos sociales en Puebla se han nutrido ampliamente de la participación de las mujeres; sobre todo, cuando hablamos de las organizaciones populares independientes (OPI). Su participación ha mantenido vivas a muchas organizaciones que de otra manera habrían desaparecido ya, pues no sólo participan en las tareas cotidianas de la organización sino, también, son las primeras en dar la cara cuando hay enfrentamientos con el gobierno y sus organizaciones corporativas, en do...

  17. Metoda stohastičnih končnih elementov v modeliranju konstrukcij

    OpenAIRE

    Melink, Teja

    2015-01-01

    V disertaciji je razvit splošni simbolni pristop k avtomatizaciji metode stohastičnih končnih elementov v modeliranju konstrukcij. Uporabljen je hibridni simbolnonumerični pristop, v katerem so kombinirani: program za simbolno računanje Mathematica, avtomatski generator kode z vgrajeno tehniko avtomatskega odvajanja AceGen, ter okolje za končne elemente AceFEM. Za opis in diskretizacijo stohastičnega polja je izbrana Karhunen-Loèvova (K-L) dekompozicija. Za izračun determinističnih členov K-L...

  18. Primerjava montessori in waldorfske pedagogike

    OpenAIRE

    Čufar, Anja

    2016-01-01

    Diplomsko delo Primerjava montessori in waldorfske pedagogike je sestavljeno iz teoretičnega in empiričnega dela. Teoretičen del vsebuje opis značilnosti montessori in waldorfske pedagogike. V njem sta omenjena Maria Montessori, začetnica pedagogike montessori, in Rudolf Steiner, začetnik waldorfske pedagogike. Tu najdemo podatke, kdaj sta se pedagogiki pojavili v svetu in kdaj v Sloveniji. V tem delu sem izpostavila kriterije, s katerimi sem primerjala montessori pedagogiko in waldorfsko ...

  19. Uporaba umetne inteligence za reševanje zahtevnih inženirskih problemov

    OpenAIRE

    Šikovec, Simon

    2013-01-01

    diplomsko delo opisuje različne metode umetne inteligence in njihovo uporabo v inženirstvu. V uvodnem delu je razčlenitev umetne inteligence in splošen opis, ki mu sledi nekaj primerov. S primeri, kot sta na primer optimizacija obdelovalnih parametrov in napovedovanje oziroma obnašanje sistema v prihodnosti, želimo pokazati, da je uporaba umetne inteligence učinkovit pristop za reševanje inženirskih problemov. Na koncu obeh primerov prikažemo, da je uporaba metod umetne inteligence učinkovita...

  20. Acousto-Optic Processing of 2-D Signals Using Temporal and Spatial Integration.

    Science.gov (United States)

    1986-04-29

    manufactured the 1 -D correlation of the nth row of f(x y) with all the for many years. Consequently reliable and relatively rowstofh(.The1-D correlation formson...sdmtos o ieadlgtm-dce ihwihw a vrom oeo h iiain dulaionare ithr th acust -optc (O)’ r te elctr- o thetwoindiidul moulaors opi E. fet.Ec yp fmdltrhsison h...Erasure Writing Mode, the conventional green light ( - 514 nm) and read out with an auxiliary red degenerate four-wave mixing geometry is modified to

  1. Robust Flight Controllers.

    Science.gov (United States)

    1983-12-01

    30C 153 GO TC 293.3 ___34:463 CALL llS(CT.KStCCICO3y~zooO 1c 33. IwMAv1hN3,osCqUM0,WINE WFqFT,8T qGToHT 0OTR9,.1 I Prt𔄃.9~ff. ,OPI’XgUX , SAGA ,OA...Aeronautical Engineering Department. Permanent Address: 3221 Twilight Court, #103 Topeka, Kansas 66109 4.5 II ," ., , . .., . . ,. ,.- ., . , , ’% . ~ -w

  2. ACCELERATORS Control system for the CSNS ion source test stand

    Science.gov (United States)

    Lu, Yan-Hua; Li, Gang; Ouyang, Hua-Fu

    2010-12-01

    A penning plasma surface H- ion source test stand for the CSNS has just been constructed at the IHEP. In order to achieve a safe and reliable system, nearly all devices of the ion source are designed to have the capability of both local and remote operation function. The control system consists of PLCs and EPICS real-time software tools separately serving device control and monitoring, PLC integration and OPI support. This paper summarizes the hardware and software implementation satisfying the requirements of the ion source control system.

  3. Modeliranje procesa biološke obrade otpadne vode na komunalnom uređaju grada Velika Gorica

    OpenAIRE

    Čurlin, M.; Bevetek, A.; Ležajić, Z.; Deverić Meštrović, B.; Kurtanjek, Ž.

    2008-01-01

    Obrada otpadne vode s aktivnim muljem izrazito je složen fizikalni, kemijski i biološki proces. Nestalnost sastava i protoka otpadne vode te vremenski promjenjive reakcije mješovite kulture mikroorganizama uvjetuju njegovu nelinearnost i nestacionarnost. Optimalno vođenje procesa je kompleksan zadatak, ali pravilno izrađen matematički model može poslužiti kao osnova za rješavanje. U ovom radu izrađena su dva modela za opis procesa obrade otpadne vode na uređaju grada Velika Gorica, sa zadaćom...

  4. Genetic analysis and molecular mapping of maize (Zea mays L.) stalk rot resistant gene Rfg1.

    Science.gov (United States)

    Yang, D E; Zhang, C L; Zhang, D S; Jin, D M; Weng, M L; Chen, S J; Nguyen, H; Wang, B

    2004-02-01

    One single pathogen Fusarium graminearum Schw. was inoculated to maize inbred lines 1,145 (Resistant) and Y331 (Susceptive), and their progenies of F(1), F(2) and BC(1)F(1) populations. Field statistical data revealed that all of the F(1) individuals were resistant to the disease and that the ratio of resistant plants to susceptive plants was 3:1 in the F(2) population, and 1:1 in the BC(1)F(1 )population. The results revealed that a single dominant gene controls the resistance to F. graminearum Schw. The resistant gene to F. graminearum Schw. was denominated as Rfg1 according to the standard principle of the nomenclature of the plant disease resistant genes. RAPD (randomly amplified polymorphic DNA) combined with BSA (bulked segregant analysis) analysis was carried out in the developed F(2) and BC(1)F(1 )populations, respectively. Three RAPD products screened from the RAPD analysis with 820 Operon 10-mer primers showed the linkage relation with the resistant gene Rfg1. The three RAPD amplification products (OPD-20(1000), OPA-04(1100) and OPY-04(900)) were cloned and their copy numbers were determined. The results indicated that only OPY-04(900) was a single-copy sequence. Then, OPY-04(900) was used as a probe to map the Rfg1 gene with a RIL F(7) mapping population provided by Henry Nguyen, which was developed from the cross "S3xMo17". Rfg1 was primarily mapped on chromosome 6 between the two linked markers OPY-04(900) and umc21 (Bin 6.04-6.05). In order to confirm the primary mapping result, 25 SSR (simple sequence repeat) markers and six RFLP (restriction fragment length polymorphism) markers in the Rfg1 gene-encompassing region were selected, and their linkage relation with Rfg1 was analyzed in our F(2) population. Results indicated that SSR marker mmc0241 and RFLP marker bnl3.03 are flanking the Rfg1 gene with a genetic distance of 3.0 cM and 2.0 cM, respectively. This is the first time to name and to map a single resistant gene of maize stalk rot through a

  5. Pojetí románu u Maria Vargase Llosy: teorie a praxe (La casa verde)

    OpenAIRE

    Dvořák, Lubor

    2007-01-01

    This study is focused on the fi rst creat ive period of the novel ist Mario Vargas Llosa, which is bordered approximately by the era of the "Boom" of the new hispanoamerican novel . The aim of this study is to out l ine Vargas Llosa's view on l i terature and i ts funct ion, wri ter and his mission, relat ionship between the fict ion and the real i ty and the piece creat ion process. The study examines these opi - nions from the point of view of thei r general val idi ty and observes the exte...

  6. Infantry Instructors’ Conference. 15-19 July 1963

    Science.gov (United States)

    1963-01-01

    primary functions are of a logistical nature. Ocl PLAY SOT N *UnG XO HG CO 4ON LOG NCr g(voCC) VR .1 am.4 INXO OPY PLAT LDR MAINT OFF MAINT SOT $UP OFF 4...operating-in the Mediter - ranean, at Normandy, and in the Southwest Pacific. The concept during the Korean conflict was that of Ranger Infantry...trailers, two 3/4-ton 7 trucks with trailers, a- 1/4-toin truck with one AN/ VR -46 radio, and a 5-ton wrecker. The maintenance platoon of the mechanized

  7. Efeito inibidor do crescimento tumoral pela metionina-encefalina

    Directory of Open Access Journals (Sweden)

    Georgia Mascarenhas

    1992-03-01

    Full Text Available A metionina-enceflalina (Met-Ehk é um pentapeptídeo opióide derivado do pró-normônio proencefalina A. presente em células neuroendócrinas e hematopoéticas. Estudos experimentais evidenciam seu papel na indução, ativação e controle de eventos imunomodula-dores, inclusive com potente efeito inibidor do crescimento tumoral. O presente estudo demonstra que o efeito inibidor da Met-Enk no crescimento de um fibro-histiocitoma, em camundongos BALB/cJ, é influenciado pelo protocolo utilizado, via de administração e dose do pentapeptídeo opióide utilizada no tratamento. A administração de Met_Enk por via intracerebral retardou de forma eficiente o processo de tumorigênese, aumentando a sobrevida dos animais e reduzindo de forma significativa a área tumoral final. Dose baixa (0,25 mg/kg de Met-Enk administrada por via intracerebral foi ainda mais potente no controle da tumorigênese.

  8. Designing a web-application to support home-based care of childhood CKD stages 3-5: qualitative study of family and professional preferences.

    Science.gov (United States)

    Swallow, Veronica M; Hall, Andrew G; Carolan, Ian; Santacroce, Sheila; Webb, Nicholas J A; Smith, Trish; Hanif, Noreen

    2014-02-18

    There is a lack of online, evidence-based information and resources to support home-based care of childhood CKD stages 3-5. Qualitative interviews were undertaken with parents, patients and professionals to explore their views on content of the proposed online parent information and support (OPIS) web-application. Data were analysed using Framework Analysis, guided by the concept of Self-efficacy. 32 parents, 26 patients and 12 professionals were interviewed. All groups wanted an application that explains, demonstrates, and enables parental clinical care-giving, with condition-specific, continously available, reliable, accessible material and a closed communication system to enable contact between families living with CKD. Professionals advocated a regularly updated application to empower parents to make informed health-care decisions. To address these requirements, key web-application components were defined as: (i) Clinical care-giving support (information on treatment regimens, video-learning tools, condition-specific cartoons/puzzles, and a question and answer area) and (ii) Psychosocial support for care-giving (social-networking, case studies, managing stress, and enhancing families' health-care experiences). Developing a web-application that meets parents' information and support needs will maximise its utility, thereby augmenting parents' self-efficacy for CKD caregiving, and optimising outcomes. Self-efficacy theory provides a schema for how parents' self-efficacy beliefs about management of their child's CKD could potentially be promoted by OPIS.

  9. Thermodynamic Description Of Ternary Fe-B-X Systems. Part 2: Fe-B-Ni

    Directory of Open Access Journals (Sweden)

    Miettinen J.

    2014-06-01

    Full Text Available Przedstawiono termodynamiczny opis trójskładnikowego układu Fe-B-Ni w kontekście nowej bazy danych dla układów Fe-B-X (X = Cr, Ni, Mn, Si, Ti, V, C. Parametry termodynamiczne dwuskładnikowych stopów Fe-B. Fe-Ni i B-Ni zostały są zaczerpnięte z wcześniejszych opracowań, przy tym opis B-Ni został nieznacznie zmodyfikowany. Parametry dla układu Fe-B-Ni zostały zoptymalizowane w tej pracy w oparciu o eksperymentalne równowagi fazowe i dane termodynamiczne zaczerpnięte z literatury. Roztwory stałe w układzie Fe-B-Ni opisano przy użyciu modelu roztworu substytucyjnego, a borki traktowane są jako fazy stechiometryczne lub półstechiometryczne typu (A.BpCq opisane przy użyciu modelu dwu podsieci.

  10. Excitation of the 6. 13-MeV state of /sup 16/O by. pi. /sup +/ mesons with momentum 2. 0 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Kirpichnikov, I.V.; Kuznetsov, V.A.; Starostin, A.S.

    1984-12-01

    We have measured the angular distribution of ..gamma.. rays with energy 6.13 MeV emitted on excitation of the 3/sup -/ level of the /sup 16/O nucleus by ..pi..'u+ mesons with momentum 2.0 GeV/c. We have determined the alignment of the nucleus in the final state and have obtained partial cross sections for the reaction /sup 16/O(..pi.., X)/sup 16/O*(3/sup -/) characterized by definite values of spin projection on the axis coinciding with the direction of the incident beam. The results of the measurements at small-pion-scattering angles are in good agreement with calculations carried out in the glauber theory for the quasielastic reaction /sup 16/O(..pi.., ..pi..')/sup 16/O*(3/sup -/). However, a significant fraction of the excitation cross section (approx. =0.5 sigma/sub exc/) is due to scattering into large angles and can be assigned to channels with production of new particles.

  11. Excitation of the /sup 16/O (6. 13 MeV) nucleus by. pi. /sup +/ mesons at the 2. 0 GeV/c momentum

    Energy Technology Data Exchange (ETDEWEB)

    Kirpichnikov, I.V.; Kuznetsov, V.A.; Starostin, A.S. (Gosudarstvennyj Komitet po Ispol' zovaniyu Atomnoj Ehnergii SSSR, Moscow. Inst. Teoreticheskoj i Ehksperimental' noj Fiziki)

    1984-12-01

    Angular distribution of ..gamma.. radiation with an energy of 6.13 MeV, emitted at the excitation of the 3- level in /sup 16/O nuclei by ..pi../sup +/ mesons with the momentum of 2.0 GeV/c, has been measured. The alignment of the final nucleus is determined, the partial cross sections of the /sup 16/O(..pi.., X)/sup 16/O* (3/sup -/) reaction characterized by the definite spin projection to axis of the incident beam direction are obtained. For small pion scattering angles the results of the measurements are in good agreement with the calculations performed in the framework of the Glauber theory for the quasi-elastic /sup 16/O(..pi.., ..pi..')/sup 16/O*(3/sup -/). However, a considerable part of the excitation cross section (approximately 0.5sigmasub(exc)) is due to the scattering at large angles and can be ascribed to channels with a particle production.

  12. Atuação da enfermeira na cordotomia cervical percutânea para controle da dor oncológica

    Directory of Open Access Journals (Sweden)

    Maria Cecília Iksilara

    2003-04-01

    Full Text Available A dor oncológica é, freqüentemente, progressiva e incapacitante. Um terço dos pacientes em tratamento e dois terços dos pacientes com doença avançada referem ter dor. Os tratamentos iniciam-se com medicações analgésicas não opióides e drogas adjuvantes, passando para opióides com aumento progressivo das doses e procedimentos neurocirúrgicos, quando há indicação. Cordotomia cervical percutânea é um procedimento neurocirúrgico para tratamento da dor oncológica unilateral, especialmente em extremidades, que proporciona alívio imediato e baixa morbidade. A participação da enfermeira na efetividade desse tratamento tem sido imprescindível, razão pela qual a autora resolveu relatar a experiência, pouco freqüente em trabalhos publicados em nosso meio.

  13. Learning from the data: mining of large high-throughput screening databases.

    Science.gov (United States)

    Yan, S Frank; King, Frederick J; He, Yun; Caldwell, Jeremy S; Zhou, Yingyao

    2006-01-01

    High-throughput screening (HTS) campaigns in pharmaceutical companies have accumulated a large amount of data for several million compounds over a couple of hundred assays. Despite the general awareness that rich information is hidden inside the vast amount of data, little has been reported for a systematic data mining method that can reliably extract relevant knowledge of interest for chemists and biologists. We developed a data mining approach based on an algorithm called ontology-based pattern identification (OPI) and applied it to our in-house HTS database. We identified nearly 1500 scaffold families with statistically significant structure-HTS activity profile relationships. Among them, dozens of scaffolds were characterized as leading to artifactual results stemming from the screening technology employed, such as assay format and/or readout. Four types of compound scaffolds can be characterized based on this data mining effort: tumor cytotoxic, general toxic, potential reporter gene assay artifact, and target family specific. The OPI-based data mining approach can reliably identify compounds that are not only structurally similar but also share statistically significant biological activity profiles. Statistical tests such as Kruskal-Wallis test and analysis of variance (ANOVA) can then be applied to the discovered scaffolds for effective assignment of relevant biological information. The scaffolds identified by our HTS data mining efforts are an invaluable resource for designing SAR-robust diversity libraries, generating in silico biological annotations of compounds on a scaffold basis, and providing novel target family specific scaffolds for focused compound library design.

  14. Recovery of gait pattern after medial patellofemoral ligament reconstruction for objective patellar instability.

    Science.gov (United States)

    Carnesecchi, O; Philippot, R; Boyer, B; Farizon, F; Edouard, P

    2016-01-01

    Gait pattern alterations were previously reported in association with objective patellar instability (OPI). Gait pattern comparison between a series of patients having undergone medial patellofemoral ligament (MPFL) reconstruction and a sample of control subjects. Thirty patients at 6 months postoperatively after MPFL reconstruction and thirty control subjects were enrolled in the study for a clinical and biomechanical assessment including gait analysis at three selected walking rates using the GAITRite(®) system. The mean raw IKDC score was 73 (± 19), and the mean Kujala knee function was 84 (± 17.5). The study of gait did not demonstrate any significant difference between the two groups at a normal and fast walking rate. At a 10 km/h running speed, the single-support phase was significantly shortened by a mean 2.33% (p clinical results in the management of OPI. At 6 months postoperatively, the patient gait pattern was similar to that observed in healthy subjects at a normal and fast walking speed. However, our study revealed persistent gait abnormalities at a 10 km/h running speed. These gait alterations seemed to be related to the ligament reconstruction in itself due to the higher strain applied on the reconstructed MPFL during running cycle (10 km/h). Level of evidence IV.

  15. Spectro radiometry Applied to Soil Science; Espectrorradiometria Aplicada a la Ciencia del Suelo

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, T.; Chabrillat, S.; Guerrero, C.; Jimenez, M.; Lopez, F.; Palacios, A.; Pelayo, M.; Rodriguez, M.

    2012-07-01

    This work is the result of an internal course that was held in CIEMAT under the framework of activities within the ''Itinerario Formativo: Tecnicas experimentales de apoyo a la Investigacion I+D+I'', as part of the Programa de Acciones Conjuntas de OPIs (CIEMAT, INTA and IGME) financed by the Instituto Nacional de Administracion Publica (INAP). The course was aimed at researchers, technical staff and students associated to the different OPIs introducing them to spectroradiometric techniques for determining soil properties and processes and obtain a thorough insight into the compilation and applications of spectral libraries. This course was directed and organized by CIEMAT with experts specialized in the field of spectro radiometry presenting the corresponding theory and application as well as practical work carried out in the laboratory and in the field. The course is within the research lines carried out by the group Unidad de Conservacion y Recuperacion de Suelos of the Departamento de Medio Ambiente in CIEMAT. (Author)

  16. Urine levels of drugs for which Triage DOA screening was positive.

    Science.gov (United States)

    Moriya, Fumio

    2009-04-01

    The purpose of this study was to investigate the relationship between urine levels of target drugs of abuse for which Triage DOA gave positive results, as well as the cut-off levels for these drugs. Thirty-eight forensic urine samples positive for commonly abused drugs were involved. Of these samples, 12 were positive for barbiturates (BAR), 11 for benzodiazepines (BZO), 8 for opiates (OPI), 7 for amphetamines (AMP), and 4 for tricyclic antidepressants (TCA). In the BAR-positive urine samples, phenobarbital, amobarbital or barbital was detected at concentrations higher than cut-off levels. In the BZO-positive samples, diazepam, nordiazepam, triazolam, nitrazepam and/or midazolam was detected at concentrations lower than cut-off levels; in the triazolam-involved urine, alpha-hydroxytriazolam, a metabolite of triazolam, showed concentrations higher than cut-off level. In the AMP-positive samples, methamphetamine was detected at concentrations higher than cut-off level. Urine samples positive for OPI contained total dihydrocodeine, codeine or morphine at concentrations higher than cut-off levels. In TCA-positive samples, amitriptyline was detected at concentrations higher or lower than cut-off level, and clomipramine was detected at a concentration much lower than cut-off level. Metabolites of BZO and TCA, which are not typically analyzed by instrumental procedures, may cross-react to varying degrees with the antibodies used for Triage DOA.

  17. Human-, Ovine-, and Bovine-Specific Viral Source Tracking Tools to Discriminate Between the Major Fecal Sources in Agricultural Waters.

    Science.gov (United States)

    Rusiñol, Marta; Moriarty, Elaine; Lin, Susan; Bofill-Mas, Sílvia; Gilpin, Brent

    2016-03-01

    This study evaluated the sources of fecal contamination in different river catchments, using a combination of microbial source tracking tools, for human, ruminant, ovine and bovine livestock, in order to define appropriate water management strategies. Every source of waterway pollution was evaluated in river water samples from one urban river catchment and two important farming regions in New Zealand. Fecal pollution was initially measured by testing Escherichia coli and evaluating the presence of human- and ruminant-associated DNA markers of Bacteroidales (BiAdo, BacHum-UCD, BacH, and BacR) and human and ruminant fecal sterols/stanols ratios. Then specific fecal pollution sources were assessed with previously reported quantitative PCR assays targeting human-, bovine-, and ovine-specific viruses: human adenoviruses (HAdV), human JC polyomaviruses, bovine polyomaviruses (BPyV), and ovine polyomaviruses (OPyV). High level of ruminant fecal contamination was detected all over the farming areas, whereas no ruminant sources were identified in the urban river sampling sites. BacR was the most frequently observed ruminant marker and OPyV and BPyV allowed the identification of ovine and bovine fecal sources. The human fecal viral marker (HAdV) was the most frequently observed human marker, highly abundant in the urban sites, and also present in farming areas. This is the first study using simultaneously the ovine and the bovine viral markers to identify and quantify both bovine and ovine fecal pollution.

  18. Influence of Propolis on Hygiene, Gingival Condition, and Oral Microflora in Patients with Cleft Lip and Palate Treated with Fixed Orthodontic Appliances

    Directory of Open Access Journals (Sweden)

    Agnieszka Machorowska-Pieniążek

    2013-01-01

    Full Text Available The aim of this study was to evaluate the influence of 3% ethanol extract of propolis (EEP on hygiene, gingival and microbiological status of oral cavity in patients with cleft lip and palate treated with fixed orthodontic appliances. The study included forty-one nonsyndromic complete unilateral of bilateral cleft lip and palate subjects with fixed appliance on at least 10 teeth. Twenty-one subjects were instructed to brush their teeth three times a day using toothpaste with propolis. Control group included twenty subjects who were asked to brush their teeth three times a day using a toothpaste without propolis. API, OPI, GI, and supragingival bacterial plaque were taken from each subject twice: baseline and after using the toothpaste for 35 days. The final examinations showed statistically significant decrease in OPI, GI, and the percentage of the Actinomyces spp. and Capnocytophaga spp. compared with baseline in propolis group subjects. The improvement in oral health in these patients confirms antibacterial, anti-inflammatory, and regenerative properties of propolis.

  19. Identification and Gene Mapping of Completely Dominant Earliness in Rice

    Institute of Scientific and Technical Information of China (English)

    DENG Xiao-jian; ZHOU Kai-da; LI Ren-duan; CHUN Ze; LI Ping; WANG Wen-ming; ZHAI Wen-xue; ZHU Li-huang

    2002-01-01

    The completely dominant earliness was identified in a genic male-sterile and early maturing indica line 6442S-7. F1 progenies from 6442S-7 crossed with thirteen various types of medium- or latematuring varieties, shared the same heading date as 6442S-7. The segregation of heading date in the F2 and B1F1 populations showed that the earliness of 6442S-7 is mainly controlled by two dominant major genes. The local linkage map of one dominant earliness gene harbored in 6442S-7 was constructed with F2 population and four kinds of molecular marker techniques. The results showed that the gene was located between a RFLPmarker C515 and a RAPD marker OPI 11. 557 on the terminal region of short arm of rice chromosome 3,10.9cM and 1.5 cM from C515 and OPI11. 557, respectively. The genetic distances from the target gene to twoSSR markers, RM22 and RM231, and one AFLP marker, PT671, were 3.0, 6.7 and 12.4 cM, respectively. This gene, being identified and mapped first, is designated tentatively as Ef-cd (t). As a new genetic resource of completely dominant earliness, 6442S-7 has splendid future in rice improvement.

  20. Oxygen isotopes unravel the role of microorganisms in phosphate cycling in soils.

    Science.gov (United States)

    Tamburini, Federica; Pfahler, Verena; Bünemann, Else K; Guelland, Kathi; Bernasconi, Stefano M; Frossard, Emmanuel

    2012-06-05

    Phosphorus (P) is considered the ultimate limiting nutrient for plants in most natural systems and changes in the distribution of inorganic and organic P forms during soil development have been well documented. In particular, microbial activity has been shown to be an important control on P cycling but its contribution in building up the pool of plant-available P during soil development is still poorly quantified. To determine the importance of different biological processes on P cycling, we analyzed the isotopic composition of oxygen in phosphate (δ(18)O-Pi) from the parent material, soil microorganisms, the available P pool, and from the vegetation along a 150-year soil chronosequence of a glacier forefield. Our results show that at all sites, δ(18)O-Pi of microbial Pi is within the range expected for the temperature-dependent equilibrium between phosphate and water. In addition, the isotopic signature of available Pi is close to the signature of microbial Pi, independently of the contribution of parent material Pi, vegetation Pi or Pi released from organic matter mineralization. Thus, we show that phosphate is cycled through soil microorganisms before being released to the available pool. This isotopic approach demonstrates for the first time in the field and over long time scales, and not only through controlled experiments, the role of the microbial activity in cycling of P in soils.

  1. Synthesis and characterization of six-membered pincer nickelacycles and application in alkylation of benzothiazole

    Indian Academy of Sciences (India)

    HANUMANPRASAD PANDIRI; DIPESH M SHARMA; RAJESH G GONNADE; BENUDHAR PUNJI

    2017-08-01

    Six-membered pincer nickelacycle complexes have been synthesized and employed for the catalytic C–H bond alkylation of benzothiazole. The pincer nickelacycle, {κP, κC, κP-(2-i Pr₂ POCH₂ C₆H₃-6-CH₂OPi Pr₂)}NiBr, [(i Pr₄-POCCCOP)NiBr (2)] was synthesized by the reaction of 1,3-i Pr₂POCH₂-C₆H₄-CH₂OPi Pr₂ [(i Pr₄-POCCCOP)−H (1)] with (CH₃CN) ₂NiBr₂ in the presence of Et₃N via the C(2)–H activation on ligand 1. Treatment of [(i Pr₄-POCCCOP)NiBr] (2) with AgOAc afforded the complex [(i Pr₄-POCCCOP)Ni(OAc)] (3) in good yield. Both the complexes 2 and 3 were characterized by ¹H,¹³C and ³¹P-NMR spectral analysis. Further, the molecular structures of complexes 2 and 3 were established by X-ray crystallography. The complex 2 was found to be an active catalyst for the C–H bond alkylation of benzothiazole with alkyl halides containing β–hydrogen atoms.

  2. Preparation of Simulated LBL Defects for Round Robin Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, Charles A [ORNL; Hunn, John D [ORNL; Montgomery, Fred C [ORNL

    2016-01-01

    A critical characteristic of the TRISO fuel design is its ability to retain fission products. During reactor operation, the TRISO layers act as barriers to release of fission products not stabilized in the kernel. Each component of the TRISO particle and compact construction plays a unique role in retaining select fission products, and layer performance is often interrelated. The IPyC, SiC, and OPyC layers are barriers to the release of fission product gases such as Kr and Xe. The SiC layer provides the primary barrier to release of metallic fission products not retained in the kernel, as transport across the SiC layer is rate limiting due to the greater permeability of the IPyC and OPyC layers to many metallic fission products. These attributes allow intact TRISO coatings to successfully retain most fission products released from the kernel, with the majority of released fission products during operation being due to defective, damaged, or failed coatings. This dominant release of fission products from compromised particles contributes to the overall source term in reactor; causing safety and maintenance concerns and limiting the lifetime of the fuel. Under these considerations, an understanding of the nature and frequency of compromised particles is an important part of predicting the expected fission product release and ensuring safe and efficient operation.

  3. Pyridine-2,6-diyl dinitroxides as room-temperature triplet ligands

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Hinako; Tonegawa, Asato; Ishida, Takayuki, E-mail: takayuki.ishida@uec.ac.jp [Department of Engineering Science, The University of Electro-Communications, Tokyo (Japan)

    2016-02-01

    We have proposed tert-butyl 2-pyridyl nitroxide radicals as a promising paramagnetic chelating ligand, where the direct radical-metal bond leads to strong magnetic interaction. We successfully synthesized and isolated PyBN derivatives (pyridine-2,6-diyl bis(tert-butyl nitroxides)). The molecular and crystal structures of the target biradicals, MesPyBN, AntPyBN and tBuOPyBN were determined from the X-ray crystal structure analysis, which possess mesityl, 9-anthryl and tert-butoxy groups at the 5-position of the pyridine ring, respectively. The ground triplet state was characterized by means of SQUID susceptometry for each compound. On heating, the χ{sub m}T values of all the PyBN derivatives increased and reached a plateau at ca. 1.0 cm{sup 3} K mol{sup −1} at 300 K. It implies that biradicals behaved as triplet molecules even at room temperature, or 2J/k{sub B} >> 300 K. From the decay monitored in solution electron-spin resonance spectroscopy, MesPyBN was the most persistent, while tBuOPyBN was the most reactive, of the three.

  4. Overexpression of the NADP+-specific isocitrate dehydrogenase gene (icdA) in citric acid-producing Aspergillus niger WU-2223L.

    Science.gov (United States)

    Kobayashi, Keiichi; Hattori, Takasumi; Hayashi, Rie; Kirimura, Kohtaro

    2014-01-01

    In the tricarboxylic acid (TCA) cycle, NADP(+)-specific isocitrate dehydrogenase (NADP(+)-ICDH) catalyzes oxidative decarboxylation of isocitric acid to form α-ketoglutaric acid with NADP(+) as a cofactor. We constructed an NADP(+)-ICDH gene (icdA)-overexpressing strain (OPI-1) using Aspergillus niger WU-2223L as a host and examined the effects of increase in NADP(+)-ICDH activity on citric acid production. Under citric acid-producing conditions with glucose as the carbon source, the amounts of citric acid produced and glucose consumed by OPI-1 for the 12-d cultivation period decreased by 18.7 and 10.5%, respectively, compared with those by WU-2223L. These results indicate that the amount of citric acid produced by A. niger can be altered with the NADP(+)-ICDH activity. Therefore, NADP(+)-ICDH is an important regulator of citric acid production in the TCA cycle of A. niger. Thus, we propose that the icdA gene is a potentially valuable tool for modulating citric acid production by metabolic engineering.

  5. O papel dos bloqueios anestésicos no tratamento da dor de origem cancerosa

    Directory of Open Access Journals (Sweden)

    Oliveira Amaury Sanchez

    2003-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Tradicionalmente os anestesiologistas desenvolveram as técnicas de anestesia regional que hoje dominam. Para participarem do tratamento dos pacientes com dores crônicas, necessitam transferir os conhecimentos adquiridos, além das indicações cirúrgicas, indicando-os no momento correto, tornando-os úteis e eficazes, num atendimento que deve ser multidisciplinar. O objetivo deste trabalho é mostrar aos anestesiologistas que os bloqueios anestésicos, no tratamento da dor crônica de origem cancerosa, para serem úteis e eficazes, devem ser indicados no momento correto inserindo-os como parte de um tratamento sistêmico, do qual deve-se participar ativamente. CONTEÚDO: O uso correto do protocolo da Organização Mundial da Saúde proporciona diretriz para o controle da dor na maioria dos pacientes com moléstia cancerosa avançada. A eficácia desta abordagem é demonstrada nos seus três primeiros passos, com pequeno número de complicações. Contudo, há pacientes que experimentam efeitos colaterais indesejáveis aos medicamentos opióides sistêmicos e a presença de metástases ósseas e as neuropatias podem determinar efeitos deletéricos nesses pacientes. Técnicas invasivas são raramente indicadas, mas podem resultar em analgesia no tratamento das dores resistentes aos opióides quando usados adequadamente. CONCLUSÕES: Bloqueios com agentes neurolíticos que exigiam alto grau de perícia dos anestesiologistas são as últimas opções de tratamento quando as drogas sistêmicas não mantêm o efeito desejado ou produzem efeitos colaterais de difícil tratamento. Bloqueios anestésicos e injeção de drogas opióides por via subaracnóidea, têm lugar de destaque no tratamento da dor de origem cancerosa e devem ser considerados em situações específicas como parte de um tratamento multidisciplinar.

  6. Avaliação da buprenorfina pelas vias intravenosa ou intramuscular em cães anestesiados pelo desfluorano

    Directory of Open Access Journals (Sweden)

    Souza Almir Pereira de

    2004-01-01

    Full Text Available Objetivou-se avaliar comparativamente os efeitos da buprenorfina, administrada pelas vias intramuscular(IM ou intravenosa (IV, sobre variáveis cardiovasculares, em cães anestesiados com desfluorano. Para tanto, foram utilizados dezesseis cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=8 denominados de GI e GII. Em ambos os grupos, a anestesia foi induzida com propofol (8 mg/kg, IV e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desfluorano (1,5 CAM. Após 30 minutos do início da anestesia inalatória, foi aplicado no GI buprenorfina na dose de 0,02 mg/kg pela via IV, enquanto no GII administrou-se o opióide na mesma dose porém pela via IM. Avaliaram-se: freqüência cardíaca (FC; pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM; débito cardíaco (DC; pressão venosa central (PVC e pressão da artéria pulmonar (PAP. As colheitas foram feitas nos seguintes momentos: M1 - 30 minutos após o início da anestesia inalatória antes da aplicação do opióide; M2 - 15 minutos após a administração da buprenorfina; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (p<0,05. As variáveis PAS, PAM, DC, PVC e PAP, não apresentaram alterações significativas de seus valores em ambos os grupos. Entretanto, a FC e a PAD apresentaram reduções significativas após a administração do opióide apenas no GI. Assim, pôde-se concluir que a buprenorfina administrada pelas vias IV ou IM não interferiu nos índices cardiovasculares de forma a manifestar efeitos clínicos importantes em cães anestesiados com desfluorano.

  7. A single-center study evaluating the effect of the controlled adverse environment (CAEsm model on tear film stability

    Directory of Open Access Journals (Sweden)

    Abelson R

    2012-11-01

    Full Text Available Richard Abelson,1,2 Keith J Lane,3 John Rodriguez,3 Patrick Johnston,3 Endri Angjeli,3 George Ousler,3 Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, 2Statistics and Data Corporation, Tempe, AZ; 3Ora, Inc, Andover, MA, USAPurpose: To investigate use of an improved ocular tear film analysis protocol (OPI 2.0 in the Controlled Adverse Environment (CAESM model of dry eye disease, and to examine the utility of new metrics in the identification of subpopulations of dry eye patients.Methods: Thirty-three dry eye subjects completed a single-center, single-visit, pilot CAE study. The primary endpoint was mean break-up area (MBA as assessed by the OPI 2.0 system. Secondary endpoints included corneal fluorescein staining, tear film break-up time, and OPI 2.0 system measurements. Subjects were also asked to rate their ocular discomfort throughout the CAE. Dry eye endpoints were measured at baseline, immediately following a 90-minute CAE exposure, and again 30 minutes after exposure.Results: The post-CAE measurements of MBA showed a statistically significant decrease from the baseline measurements. The decrease was relatively specific to those patients with moderate to severe dry eye, as measured by baseline MBA. Secondary endpoints including palpebral fissure size, corneal staining, and redness, also showed significant changes when pre- and post-CAE measurements were compared. A correlation analysis identified specific associations between MBA, blink rate, and palpebral fissure size. Comparison of MBA responses allowed us to identify subpopulations of subjects who exhibited different compensatory mechanisms in response to CAE challenge. Of note, none of the measures of tear film break-up time showed statistically significant changes or correlations in pre-, versus post-CAE measures.Conclusion: This pilot study confirms that the tear film metric MBA can detect changes in the ocular surface

  8. Thiazolidone derivatives as inhibitors of chikungunya virus.

    Science.gov (United States)

    Jadav, Surender Singh; Sinha, Barij Nayan; Hilgenfeld, Rolf; Pastorino, Boris; de Lamballerie, Xavier; Jayaprakash, Venkatesan

    2015-01-07

    A series of arylalkylidene derivatives of 1,3-thiazolidin-4-one (1-20) were synthesized and tested for their antiviral activity against chikungunya virus (LR2006_OPY1) in Vero cell culture by CPE reduction assay. Five compounds (7-9, 16 and 19) were identified to have anti-ChikV activity at lower micro molar concentration. The compounds 7, 8, 9, 16 and 19 inhibited the virus at 0.42, 4.2, 3.6, 40.1 and 6.8 μM concentrations respectively. Molecular docking simulation has been carried out using the available X-ray crystal structure of the ChikV nsp2 protease, in order to elucidate the possible mechanism of action. Interaction of ligands with ChikV nsp2 protease (PDB Code: 3TRK) suggested the possible mechanism of protease inhibition to act as potent anti-ChikV agents.

  9. A hybrid algorithm for the segmentation of books in libraries

    Science.gov (United States)

    Hu, Zilong; Tang, Jinshan; Lei, Liang

    2016-05-01

    This paper proposes an algorithm for book segmentation based on bookshelves images. The algorithm can be separated into three parts. The first part is pre-processing, aiming at eliminating or decreasing the effect of image noise and illumination conditions. The second part is near-horizontal line detection based on Canny edge detector, and separating a bookshelves image into multiple sub-images so that each sub-image contains an individual shelf. The last part is book segmentation. In each shelf image, near-vertical line is detected, and obtained lines are used for book segmentation. The proposed algorithm was tested with the bookshelf images taken from OPIE library in MTU, and the experimental results demonstrate good performance.

  10. An Iterative Technique for Designing Finite Impulse Response Chebyshev MTI Filters with Nonlinear Delay

    Science.gov (United States)

    1978-03-01

    Passband Ripple Passband Lower Passbaisd Ripple Passband Lower in Passband Weights N Edge IHz) fPASS (d8) RPe Edge ( Hzj fPASS (dB) RpB Edge (Hz) Ripple (dB...NN IIV 24 THIS PAGE IS BtST QUALITY MR&QXCABLE RhM COrY R±albH.Md TD DDC . w u- w F-ii W _jL 4 0 W X Z-C :1[M (’ ’ ’ 𔃻(4C z z3 z 11 z k-i I 1’ t...L~ THIS PAGE IS BEST QUALITY PRACTICABLE 31 EFOM OPY FUlRNISIE TD DDQ .~ x z S. < w W, w r -c N 0 r z~’ Nr Z-C14c;L ciw I-- ED w w. w’ ;= ’L 0 to CC

  11. Langley Integrated Total Force (L-ITF) Beddown and Logistics Support Center (LSC) Environmental Assessment

    Science.gov (United States)

    2006-05-01

    Please contact me at (804) 698-4:l?5 or John Asher at (804) 698-4339 for darification or these comments. Sincerely. Ellie Irons. Program Manager...sent on 11 Milyl $Cih’>fE<ctorlly adaress your comment$ 011 our Draft EA II everything ls In order. please contact Mr John Asher at the VDEQ Ofrrce...EnYJtonmental Rev1e1v Coordmulor TO: DATE: C.:OPIES: S I "BJ’ECT: Apr1l 10.2006 San jay 11unmaR,ari. W:tste 01V1~1uo Eti\\’I!Onmenu&J ReVJew Man~)’lcr

  12. Técnicas de anestesia loco-regional en la clínica felina

    OpenAIRE

    S. Cervantes

    2011-01-01

    El desarrollo de la cirugía y el control del dolor producido por ésta hacen muy útil la aplicación de técnicas de anestesia local en la especie felina. Las características diferenciales de esta especie hacen necesario que se conozca detalladamente los fármacos y las técnicas utilizadas para que su aplicación sea útil e inocua. En una primera parte del artículo profundizaremos en los principales fármacos utilizados (opiáceos, alfa2-agonistas y anestésicos locales) y en sus propiedades; en la s...

  13. Modeling of Damage Evolution and Martensitic Transformation in Austenitic Steel at Cryogenic Temperature

    Directory of Open Access Journals (Sweden)

    Ryś Maciej

    2015-12-01

    Full Text Available W artykule przedstawiono konstytutywny model materiału podlegającemu przemianie fazowej wywołanej odkształceniami plastycznymi oraz rozwojowi uszkodzeń. Przemiana fazowa opisana jest modelem liniowym. Ponadto, w pracy uwzględniono izotropowy rozwój uszkodzeń. Opis konstytutywny został zaimplementowany w komercyjnym programie Abaqus/Explicit z wykorzystaniem zewnętrznej procedury użytkownika VUMAT. Dokonano symulacji testu jednoosiowego rozciągania w celu porównania wyników eksperymentalnych z numerycznymi. Jako przykład rzeczywistego elementu konstrukcyjnego, pracującego w warunkach temperatur kriogenicznych, dokonano symulacji pracy kompensatora.

  14. The Open Perimetry Interface: an enabling tool for clinical visual psychophysics.

    Science.gov (United States)

    Turpin, Andrew; Artes, Paul H; McKendrick, Allison M

    2012-01-01

    Perimeters are commercially available instruments for measuring various attributes of the visual field in a clinical setting. They have several advantages over traditional lab-based systems for conducting vision experiments, including built-in gaze tracking and calibration, polished appearance, and attributes to increase participant comfort. Prior to this work, there was no standard to control such instruments, making it difficult and time consuming to use them for novel psychophysical experiments. This paper introduces the Open Perimetry Interface (OPI), a standard set of functions that can be used to control perimeters. Currently the standard is partially implemented in the open-source programming language R on two commercially available instruments: the Octopus 900 (a projection-based bowl perimeter produced by Haag-Streit, Switzerland) and the Heidelberg Edge Perimeter (a CRT-based system produced by Heidelberg Engineering, Germany), allowing these instruments to be used as a platform for psychophysical experimentation.

  15. Absorbing angles, Steiner minimal trees, and antipodality

    CERN Document Server

    Martini, Horst; de Wet, P Oloff; 10.1007/s10957-009-9552-1

    2011-01-01

    We give a new proof that a star $\\{op_i:i=1,...,k\\}$ in a normed plane is a Steiner minimal tree of its vertices $\\{o,p_1,...,p_k\\}$ if and only if all angles formed by the edges at o are absorbing [Swanepoel, Networks \\textbf{36} (2000), 104--113]. The proof is more conceptual and simpler than the original one. We also find a new sufficient condition for higher-dimensional normed spaces to share this characterization. In particular, a star $\\{op_i: i=1,...,k\\}$ in any CL-space is a Steiner minimal tree of its vertices $\\{o,p_1,...,p_k\\}$ if and only if all angles are absorbing, which in turn holds if and only if all distances between the normalizations $\\frac{1}{\\|p_i\\|}p_i$ equal 2. CL-spaces include the mixed $\\ell_1$ and $\\ell_\\infty$ sum of finitely many copies of $R^1$.

  16. The spaces of the margin. History of Sexuality and LGBTIQ studies from an interdisciplinary perspective

    Directory of Open Access Journals (Sweden)

    Elisabetta Bini

    2013-10-01

    Full Text Available The essay offers an overview of LGBTIQ studies, by analyzing several texts that have influenced the debate and research about the history of sexuality and LGBTIQ identities. The first part examines the forms of exchange and contamination between LGBTIQ and historical studies. The author argues that, since they emerged in the 1970s, LGBTIQ studies have aimed at challenging the specific forms of discrimination carried out against gays and lesbians, by highlighting the historical and social construction of sexuality and sexual identities. The essay focuses in particular on the importance of works by Michel Foucault, Adrienne Rich, Monique Wittig, Judith Butler, Teresa de Lauretis and American “women of color,” and their influence on historical research. The second part of the essay examines the photographs taken by several artists whose work focuses on sexual identities, such as Claude Cahun, Nan Goldin, Catherine Opie and Del LaGrace Volcano.

  17. A New Generation of Visible-Light Curing Units

    Science.gov (United States)

    1988-12-01

    OP50 , OPI01, OP300, OP400) Danbury...6.0 x 5.875 6.00 Yes 5. OP50 1.875 x 3.0 x 4.25 3.25 No 6. OP101 2.0 x 4.250 x 3.00 3.00 No 7. OP300 2.0 x 6.875 x 4.25 4.30 No 8. OP400 5.0 x 6.25 x...Unit to wand cord length 1. Trans 8𔃺" 7𔃺" 2. Visi 610" 710" 3. Helio 6𔄀" 5󈧷 4. Pris 7𔄃" 6𔄁" 5. OP50 919" 6󈧭 6. OP101 5𔄁" 5𔃺 7. OP300 5𔄂"

  18. Fiziologija laktacije i mehanička mužnja

    OpenAIRE

    Džidić, Alen

    1999-01-01

    Glavni cilj ovog članka je da opiše interakciju između fiziologije laktacije i mehaničke mužnje. To je važno da bi se izbjegli loši utjecaji (npr: mastitis, broj somatskih stanica, itd.). Dio u kojem je opisana anatomija vimena prikazuje kakvo je vime potrebno da bi ono bilo zdravo i imalo visok prinos mlijeka. Dio u kojem je opisana mehanička mužnja pokazuje parametre mužnje potrebne za dobru i jednostavnu mužnju. Glavni zaključak o interakciji između fiziologije laktacije i mehaničke mužnje...

  19. Neurological manifestations of HIV-AIDS at a tertiary care center in western Maharashtra

    Directory of Open Access Journals (Sweden)

    Virendra C Patil

    2014-07-01

    Full Text Available Background: There is an increasing incidence of patients infected with human immunodeficiency virus (HIV in India. The neurological manifestations of the disease are being seen more frequently. The nervous system is the most frequent and serious target of HIV infection. Aims and Objectives: To elucidate the spectrum of neurological involvement in patients with HIV infection at a tertiary care teaching hospital in western Maharashtra. We investigated various neurological manifestations of HIV including opportunistic infections (OPIs and non-opportunistic infections (non-OPIs. Settings and Design: This was a retrospective observational study conducted at a tertiary care center in western Maharashtra over a period of 2 years from Jan 2009 to Dec 2010. Materials and Methods: A total of 81 HIV seropositive patients of both genders, of age >18 years, with neurological manifestations admitted at a tertiary care center were studied for clinical parameters, laboratory investigations and imaging. Statistical Analysis: Data were coded by numbers and double entered in a computer software SSPE-11 trial version. Results: A total of 179 patients admitted with HIV infection, of which 81 (45.25% presented with neurological manifestations (neuro-acquired immunodeficiency syndrome [AIDS], were enrolled in the study. Overall, 53 (65.43% patients were male (34 years ± 11 and 28 (34.56% were female (29 years ± 8. The male patients were outnumbered compared with the female patients, with P = 0.02. A total of 45 (55.55% patients had OPIs and 36 (44.44% patients had non-oppurtunistic neurological manifestations affecting the nervous system (P = 1573; insignificant. A total of 15 (18.51% patients had immune reconstitution syndrome on antiretroviral therapy (A total of 11 (13.58% patients had seizures, eight (9.87% had ischemic stroke, eight (9.87% had aseptic meningitis, two (2.46% had intracranial hemorrhage, two (2.46% had vacuolar myelopathy, four (4.93% had AIDS

  20. Functions of generalized bounded variation and summability of Fourier series

    Energy Technology Data Exchange (ETDEWEB)

    D' Antonio, L.A.

    1986-01-01

    A definition is given for a Banach space of regulated functions in a manner analogous to that for functions of ordered ..lambda..-bounded variation, but using intervals of equal length and requiring that the functions satisfy a generalized continuity condition. A summability method is given that is effective on Fourier series of function in this Banach space but not on Fourier series of functions in larger such spaces. This method is defined as the convolution of a function with a kernel obtained by multiplying the Dirichlet kernel with a certain simple function, where this simple function is 2..pi..-periodic, even, and decreasing on (O,..pi..). Two methods equivalent to this method are also discussed, and analogues of the Dini test and the localization principles are proven. Finally, necessary and sufficient conditions are given for everywhere convergence and for uniform convergence of the summability method under every change of variable.

  1. Agent orange herbicides, organophosphate and triazinic pesticides analysis in olive oil and industrial oil mill waste effluents using new organic phase immunosensors.

    Science.gov (United States)

    Martini, Elisabetta; Merola, Giovanni; Tomassetti, Mauro; Campanella, Luigi

    2015-02-15

    New immunosensors working in organic solvent mixtures (OPIEs) for the analysis of traces of different pesticides (triazinic, organophosphates and chlorurates) present in hydrophobic matrices such as olive oil were developed and tested. A Clark electrode was used as transducer and peroxidase enzyme as marker. The competitive process took place in a chloroform-hexane 50% (V/V) mixture, while the subsequent enzymatic final measurement was performed in decane and using tert-butylhydroperoxide as substrate of the enzymatic reaction. A linear response of between about 10nM and 5.0μM was usually obtained in the presence of olive oil. Recovery tests were carried out in commercial or artisanal extra virgin olive oil. Traces of pesticides were also checked in the oily matrix, in pomace and mill wastewaters from an industrial oil mill. Immunosensors show good selectivity and satisfactory precision and recovery tests performed in olive oil gave excellent results.

  2. The New Edition of Chopin’s Correspondence

    Directory of Open Access Journals (Sweden)

    Helman-Bednarczyk Zofia

    2016-12-01

    Full Text Available Some of Fryderyk Chopin’s letters were published individually or in groups already in the 2nd half of the 19th century. With the passage of time, more letters from and to Chopin were printed in monographs dedicated to his life and work. The first editions of Chopin’s collected letters come from the 1st half of the 20th century (by Scharlitt and von Guttry in Germany, Henryk Opieński – in Poland. B.E. Sydow’s Fryderyk Chopin’s Correspondence of 1955 continues to be used as the basic source edition by Chopin biographers. It has many strong points, but has become largely outdated.

  3. Production of yogurt with enhanced levels of gamma-aminobutyric acid and valuable nutrients using lactic acid bacteria and germinated soybean extract.

    Science.gov (United States)

    Park, Ki-Bum; Oh, Suk-Heung

    2007-05-01

    Yogurt with high levels of gamma-aminobutyric acid (GABA), free amino acids and isoflavones was developed using lactic acid bacteria (LAB) and germinated soybean extract. Fermented soya milk (GABA soya yogurt) produced with starter and substrate had the GABA concentration of 424.67 microg/gDW, whereas fermented milk produced by a conventional method had GABA less than 1.5 microg/gDW. The GABA soya yogurt also contained significantly high levels of free amino acids and isoflavones compared with other conventional yogurts. The results suggested that the Lactobacillus brevis OPY-1 and germinated soybean possessed a prospect to be applied in dairy and other health products with high nutritive values and functional properties.

  4. USO DE DROGAS PSICOTRÓPICAS POR POLICIAIS MILITARES DE GOIÂNIA E APARECIDA DE GOIÂNIA, GOIÁS, BRASIL

    OpenAIRE

    Costa,Sérgio Henrique Nascente

    2009-01-01

    Drogas lícitas, como o álcool, e ilícitas, como a maconha, a cocaína, os opióides e as anfetaminas são utilizadas por milhões de pessoas no mundo. Os prejuízos à saúde ocorrem em virtude da intoxicação aguda ou crônica, e também devido às alterações comportamentais e psicomotoras que essas substâncias provocam nos usuários. Uma das situações que merecem especial atenção é o uso de drogas no ambiente de trabalho, notadamente em empresas e/ou instituições que necessitam de con...

  5. Uso abusivo de benzidamina no Brasil: uma abordagem em farmacovigilância

    OpenAIRE

    2010-01-01

    p.717-724 O uso abusivo de medicamentos tem sido objeto de crescente interesse em saúde pública e geralmente veiculado na imprensa brasileira. Dentre os medicamentos, objeto de abuso e que causam dependência física e/ou psíquica, incluemse os barbitúricos, benzodiazepínicos, analgésicos opióides e anfetaminas. Os analgésicos, antitérmicos e antiinflamatórios não esteroidais, apesar de não fazerem parte dessa relação de fármacos, estão, geralmente, associados ao uso recreativo ou fins não t...

  6. Metal Stents in Management of Pancreatic Pseudocyst and Walled Off Necrosis

    Directory of Open Access Journals (Sweden)

    Rajesh Paramasivam

    2016-08-01

    Full Text Available The science behind pancreatitis and its complications is an ever evolving and challenging field. More than two centuries after the first description of pancreatic pseudocyst by Eugene Opie, some clear consensus and guidelines have evolved. Atlanta Symposium in 1992 attempted to offer a global ‘consensus’ and a universally applicable classification system for acute pancreatitis, tough comprehensive; some of the definitions were confusing [1]. Recent data and deeper understanding of pathophysiology of organ failure and necrotising pancreatitis, and the advent of superior diagnostic imaging have propelled towards the formation of revised Atlanta classification in 2012. Local complications of acute pancreatitis among others are acute pancreatic fluid collection, pancreatic pseudocyst, acute necrotic collection and walled-off necrosis. Rarer complications are gastric outlet dysfunction, splenic and portal vein thrombosis, and colonic necrosis

  7. Ocena jakości obsługi klienta w procesie kształtowania jego satysfakcji

    OpenAIRE

    2012-01-01

    Celem pracy jest analiza wybranych sposobów oceny jakości obsługi klienta w procesie kształtowania jego satysfakcji. W pracy skupiono się na istocie i zastosowaniu mystery shopping. W części teoretycznej pracy zostały przedstawione wybrane zagadnienia z zakresu marketingu usług, satysfakcji klienta, standardów obsługi klienta, a także metodologia badań satysfakcji klienta. W części praktycznej pracy znajduje się opis badania jakości obsługi klientów ING Banku Śląskiego, kt...

  8. Recursions for statistical multiple alignment.

    Science.gov (United States)

    Hein, Jotun; Jensen, Jens Ledet; Pedersen, Christian N S

    2003-12-09

    Algorithms are presented that allow the calculation of the probability of a set of sequences related by a binary tree that have evolved according to the Thorne-Kishino-Felsenstein model for a fixed set of parameters. The algorithms are based on a Markov chain generating sequences and their alignment at nodes in a tree. Depending on whether the complete realization of this Markov chain is decomposed into the first transition and the rest of the realization or the last transition and the first part of the realization, two kinds of recursions are obtained that are computationally similar but probabilistically different. The running time of the algorithms is O(Pi id=1 Li), where Li is the length of the ith observed sequences and d is the number of sequences. An alternative recursion is also formulated that uses only a Markov chain involving the inner nodes of a tree.

  9. Model improwizacji polifonicznej na tle popularnych metod improwizacji w muzyce rozrywkowej

    Directory of Open Access Journals (Sweden)

    Adam Fulara

    2012-12-01

    Full Text Available Artykuł składa się z dwóch części. Pierwsza z nich, bardziej ogólna, zawiera opis zjawisk związanych z improwizacją, zwłaszcza gitarową, z wyszczególnieniem problemów wykonawczych stojących przed improwizatorem. Dwa punkty widzenia zostały przedstawione: pierwszy, szczegółowy, opisuje po kolei elementy muzyki i ich znaczenie w procesie improwizacji, drugi bardziej ogólny mówi o zjawiskach, których nie da się opisać, ani analizować w prosty sposób, bądź są inne w przypadku każdego utworu. Należy do nich interakcja pomiędzy członkami zespołu, wyrażanie emocji poprzez muzykę i problematykę poszukiwań własnego głosu w sztuce. Ta część zawiera jeszcze opis trzech zupełnie różnych podejść do improwizacji na gitarze. Pierwsza to wykorzystanie centrum tonalnego (wzbogaconego napięciami dominantowymi, druga metoda polega na połączeniu harmonii utworu ze stosowanymi skalami (stosowana w muzyce fusion, trzecia polega na ścisłym wykorzystaniu dźwięków akordowych w improwizacji bez stosowania skal (charakterystyczna dla muzyki bebop. Druga część tekstu zawiera opis szczególnego rodzaju improwizacji polifonicznej z wykorzystaniem tappingu oburęcznego na gitarze. Model ten stoi w opozycji do trzech wcześniej przedstawionych sposobów rozumienia improwizacji gitarowej. System opiera się zarówno na metodach stosowanych w polifonii renesansu i baroku (m. in. melodia wiodąca Cantus Firmus, reguły kontrapunktu, jak i na założeniach jednogłosowej improwizacji bebopowej (wykorzystanie dźwięków wiodących, rozwiązania charakterystyczne dla czterodźwięków naturalnych. Opis ten nawiązuje do pierwszej części artykułu, grupując zagadnienia wokół poszczególnych elementów dzieła muzycznego. Ta część zawiera uwagi i spostrzeżenia zebrane w ciągu ośmiu lat poszukiwań własnej drogi muzycznej autora.

  10. The new control system of HLS linac and transport line

    Institute of Scientific and Technical Information of China (English)

    LIU Gong-Fa; LI Wei-Min; LI Jing-Yi; LI Chuan; CHEN Li-Ping; BAO Xun; WANG Ji-Gang; XUAN Ke

    2005-01-01

    The new linac and transport line control system of Hefei Light Source (HLS) is a distributed control system based on EPICS (Experimental Physics and Industrial Control System). Industrial PC (IPC) is widely used as not only Input/Output Controller (IOC) but also device controller. Besides industrial PC, PLC and microcontroller are also used as device controllers. The software for industrial PC based device controller is developed based on VxWorks real-time operating system. The software for PLC and microcontroller are written with ladder software package and assemble language, respectively. PC with Linux and SUN workstation with Solaris are used as operator interfaces (OPI). High level control is made up of some EPICS tools and Tcl/Tk scripts.

  11. Development of an Integrated Performance Model for TRISO-Coated Gas Reactor Particle Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Petti, David Andrew; Miller, Gregory Kent; Martin, David George; Maki, John Thomas

    2005-05-01

    The success of gas reactors depends upon the safety and quality of the coated particle fuel. The understanding and evaluation of this fuel requires development of an integrated mechanistic fuel performance model that fully describes the mechanical and physico-chemical behavior of the fuel particle under irradiation. Such a model, called PARFUME (PARticle Fuel ModEl), is being developed at the Idaho National Engineering and Environmental Laboratory. PARFUME is based on multi-dimensional finite element modeling of TRISO-coated gas reactor fuel. The goal is to represent all potential failure mechanisms and to incorporate the statistical nature of the fuel. The model is currently focused on carbide, oxide nd oxycarbide uranium fuel kernels, while the coating layers are the classical IPyC/SiC/OPyC. This paper reviews the current status of the mechanical aspects of the model and presents results of calculations for irradiations from the New Production Modular High Temperature Gas Reactor program.

  12. Exploring a Novel Mechanism of Docetaxel Resistance in Prostate Cancer

    Science.gov (United States)

    2014-05-01

    pros~ tto ~:"’OW" DTX ~fi!!S IU ~~~be JetiVII"/ fly 1."\\1’~ I’Mte!~o~~.Ja ~!IOI"t, \\lo’t);ch ruds 10 G4,.11. ot1 ~ ~•• u4 ·~~’ ~~ Howt-Y.,, 1":虫...P’Cilla c.a.no.r o.I!J ttO ’+- DTX· .-.o~ cytot~ty &.’let G2;Mtn.tOCJC ll’l’ttt F ... ~t. l~ ey!Opi’«~Wt ... Kt ~r CXCl t2 W.JJ ’-*’Jo.td ~1’#𔃻 Pl"•trt

  13. Importância da avaliação e padronização analgésica em serviços de emergência Importancia de la evaluación y estandartización analgésica en servicios de emergencia Importance of pain evaluation and standardization of analgesic medication in emergency services

    Directory of Open Access Journals (Sweden)

    Ana Marial Calil

    2010-01-01

    Full Text Available OBJETIVOS: Conhecer a medicação antiálgica utilizada em pacientes que sofreram acidentes de transporte, o padrão analgésico e pontuar a intensidade da dor. MÉTODOS: Estudo descritivo, exploratório e longitudinal com abordagem quantitativa, que abrangeu 100 pacientes envolvidos em acidentes de transporte admitidos para tratamento em hospital referência para trauma. RESULTADOS: A dor foi identificada em 90,0% dos pacientes, sendo as de forte e média intensidade as mais frequentes; não se encontrou prescrição antiálgica em 48% dos casos. Maior uso medicamentoso foi encontrado em vítimas com lesões em membros e nos sete casos em que a dor foi totalmente aliviada, 5 (66,7% foram utilizados opióides. CONCLUSÃO: A dor é um fenômeno comum associado ao trauma com sub-tratamento e sub-avaliação em nosso meio, e o uso de opióides para dores reconhecidamente muito intensas ainda é um recurso pouco utilizado na emergência, mesmo em pacientes hemodinamicamente estáveis e com Escala de Coma de Gasglow=15.OBJETIVOS: Conocer los medicamentos antiálgicos utilizados en pacientes que sufrieron accidentes de transporte, conocer el estándar analgésico y dar puntajes a la intensidad del dolor. MÉTODOS: Estudio descriptivo, exploratorio y longitudinal con abordaje cuantitativo, que comprendió 100 pacientes que sufrieron accidentes de transporte y fueron admitidos para tratamiento en un hospital de referencia para tratamiento de traumas. RESULTADOS: El dolor fue identificado en 90,0% de los pacientes, siendo los dolores más frecuentes los de fuerte y media intensidad; no se encontró prescripción antiálgica en 48% de los casos. El mayor uso medicamentoso fue encontrado en víctimas con lesiones en miembros y entre los siete casos en que el dolor fue totalmente aliviado, en 5 (66,7% fueron utilizados opiáceos. CONCLUSIÓN: El dolor es un fenómeno común asociado al trauma con sub-tratamiento y sub-evaluación en nuestro medio, y el uso

  14. Ocena vpliva znanja zaposlenih v zdravstveni negi na obravnavo mladostnikov s samopoškodovalnim vedenjem

    OpenAIRE

    Pintar Babič, Matejka

    2016-01-01

    Z izrazom nesamomorilno samopoškodovalno vedenje opišemo namerno povzročanje poškodb lastnega telesa na način, ki ni družbeno sprejemljiv in nima samomorilnega namena. Najpogostejše je v obdobju mladostništva. Posameznikom prinaša različne ugodnosti, načeloma pa služi kot način lajšanja notranjih napetosti. Večina mladostnikov, ki se samopoškodujejo, to storijo z namenom, da bi se pomirili, sprostili in ponovno zmogli nadzorovati svojo čustveno stisko. Prve zapise o samopoškodovalnem vedenju ...

  15. La cannabis.

    Directory of Open Access Journals (Sweden)

    José Vicente Stalrich Canet

    1981-01-01

    Full Text Available En los últimos 20 ó 30 años hemos visto nuevos tipos de drogas que anteriormente no existían en nuestro mundo occidental o bien tenían una difusión bastante localizada y estable; me refiero, sobre todo, a los psicofármacos, los opiáceos y la cannabis corno las más importantes sin olvidar, no obstante, otras también actuales: los alucinógenos (sintéticos y naturales, inhalantes, etc. Estas nuevas r drogas conviven en nuestra sociedad con las otras más clásicas y generadoras de multitud de problemas como son el alcohol y el tabaco

  16. La cannabis.

    OpenAIRE

    José Vicente Stalrich Canet

    1981-01-01

    En los últimos 20 ó 30 años hemos visto nuevos tipos de drogas que anteriormente no existían en nuestro mundo occidental o bien tenían una difusión bastante localizada y estable; me refiero, sobre todo, a los psicofármacos, los opiáceos y la cannabis corno las más importantes sin olvidar, no obstante, otras también actuales: los alucinógenos (sintéticos y naturales), inhalantes, etc. Estas nuevas r drogas conviven en nuestra sociedad con las otras más clásicas y generadoras de multitud de pro...

  17. Asistencia a las urgencias psiquiátricas en Albacete.

    Directory of Open Access Journals (Sweden)

    Miguel Abia Cuchillo

    1992-01-01

    Full Text Available Se han examinado las características de los pacientes atendidos en la Unidad de Urgencias Psiquiátricas de Albacete durante el año 1990. De los datos obtenidos destacan: 1 Los trastornos por alcohol y opiáceos fueron el grupo más numeroso, con casi un tercio de las urgencias. 2 Casi los dos tercios de las urgencias estuvieron entre las edades de 15 a 40 años. 3 Casi la cuarta parte de las mismas se quedaron ingresadas en la Unidad de Hospitalización Psiquiátrica. Y 4 La escasa incidencia de las urgencias enviadas por el juez.

  18. Estudo da atividade antidiarréica e antisecretória intestinal do látex do Croton urucurana Baill

    Directory of Open Access Journals (Sweden)

    Luilma Albuquerque Gurgel

    2002-01-01

    Full Text Available O presente trabalho tem por objetivo avaliar uma possível atividade antidiarréica e anti-secretória intestinal do látex do Croton urucurana Baill. justificando seu uso como antidiarréico. Foram utilizados os modelos animais de diarréia induzida por óleo de rícino e secreção intestinal induzida pela toxina da cólera. Os resultados sugerem que o látex apresenta atividade antidiarréica, confirmando seu uso popular. Muito embora seu mecanismo de ação não seja claro, seu efeito é independente da participação de mecanismo opióide ou nitriérgico.

  19. Técnicas de anestesia loco-regional en la clínica felina

    OpenAIRE

    Cervantes, S.

    2011-01-01

    El desarrollo de la cirugía y el control del dolor producido por ésta hacen muy útil la aplicación de técnicas de anestesia local en la especie felina. Las características diferenciales de esta especie hacen necesario que se conozca detalladamente los fármacos y las técnicas utilizadas para que su aplicación sea útil e inocua. En una primera parte del artículo profundizaremos en los principales fármacos utilizados (opiáceos, alfa2-agonistas y anestésicos locales) y en sus propiedades; en la s...

  20. Aptitud física y educación: su estudio y aplicabilidad en el ámbito de la educación secundaria

    OpenAIRE

    Martínez-López, Emilio José

    2011-01-01

    El punto de partida de este trabajo de investigación, tiene como núcleo principal la evaluación de la condición física en la educación física de las enseñanzas medias. La hipótesis principal, se origina en la consideración de que para llevar a cabo dicha evaluación se deben aplicar al alumnado pruebas de aptitud física. La estructura de este trabajo presenta cuatro objetivos principales: 1,- Conocer la calidad de las pruebas de aptitud física aplicables en educación física. 2,- Conocer la opi...

  1. Ketamina en el manejo del dolor refractario por cáncer

    Directory of Open Access Journals (Sweden)

    Karla Sofía Vargas Rumoroso

    2006-06-01

    Full Text Available Los pacientes con cáncer presentan dolor en el rango entre moderado e intenso durante el transcurso de su enfermedad, principalmente en la etapa terminal. La escalera analgésica de la Organización Mundial de la Salud (OMS se ha empleado como guía terapéutica para tratar a estos pacientes; utiliza tres grupos de fármacos: opiáceos, antiinflamatorios no esteroideos (AINES y coadyuvantes. Dentro de estos últimos se encuentra la ketamina, un derivado fenciclidínico que interactúa con los receptores N-metil-D-aspartato (NMDA. Tradicionalmente ha sido utilizado como inductor de la anestesia general, y en dosis subanestésicas se emplea para el tratamiento del dolor refractario al uso de opioides.

  2. The potential toxicity of diazinon on physiological factors in male rat.

    Science.gov (United States)

    Alahyary, P; Poor, M Ilkhani; Azarbaijani, F Fathy; Nejati, V

    2008-01-01

    Diazinon is an Organophosphate Insecticide (OPI) is commonly used in agriculture to protect of crops and to control pests in home gardens and farms. Many alterations observed by diazinon have been described, such as; alterations in blood factors (RBC, Hb and Hct), plasma testosterone and glucose levels. We selected 12 albino Wistar rats weighting between 220-280 g were divided into two experimental groups, as follow, control group and diazinon treated group. The effects of diazinon, on rat interstitial cell testosterone production, blood factors and plasma glucose levels were evaluated. Male rats were treated orally with a single dose of 1/4 LD50 of diazinon. Animals received treatment for 28 days. Present results indicated that in diazinon treated group, plasma glucose and testosterone levels increased compared to control. Also in diazinon group, reduce of blood factors were observed than control. In conclusion, diazinon disturbs the synthesis of testosterone and glucose release from liver into blood and it led to anemia.

  3. Dor neuropática induzida : efeito da natação sobre a alodinia mecânica, serotonina e CGRP (peptídeo relacionado ao gene da calcitonina) no corno dorsal da medula espinhal de ratos

    OpenAIRE

    2009-01-01

    O objetivo deste estudo foi analisar os efeitos de um protocolo de natação sobre a alodinia mecânica e possíveis alterações no corno dorsal da medula espinhal de ratos machos adultos com dor neuropática crônica experimental, induzida por constrição crônica do nervo ciático. No experimento 1 foi testado o efeito do protocolo de natação na produção de analgesia e se este é mediado pelo sistema opióide endógeno em ratos com dor muscular crônica experimental. No experimento 2, estudou-se o efeito...

  4. Identification of surveillance and control priority areas for dengue and other arboviruses transmitted by Aedes aegypti in Natal-RN, Brazil: experience report.

    Science.gov (United States)

    Barbosa, Isabelle Ribeiro; Tavares, Alessandre de Medeiros; Torres, Úrsula Priscila da Silva; Nascimento, Carlos André do; Moura, Márcia Cristina Bernardo de Melo; Vieira, Valderi Barbosa; Araújo, Josélio Maria Galvão de; Gama, Renata Antonacci

    2017-01-01

    to report the vigi@dengue experience, held in the municipality of Natal-RN, Brazil, from October/2015 to May/2016. entomological indicators were obtained from the oviposition traps, epidemiological indicators from notifications on the online Information System for Notifiable Diseases (Sinan-dengue), active search for cases and viral RNA detection (RTq-PCR) in arthropods and human serum samples; risk levels have been created based on these indicators; categories of interventions for each risk level have been established. early identification of epidemics in three areas of the municipality, with guidance for field work for the most vulnerable areas; the municipality presented ovitrap positivity index (OPI) of 40% and eggs density index (EDI) of 51 eggs/ovitraps; identification of CHIKV, DENV-1 and DENV-3 in Natal-RN. the strategy identified the early emergence of epidemics in specific locations; it was helpful in the guidance of control measures for the areas of major risk.

  5. Insights into the Deactivation of 5-Bromouracil after UV Excitation

    CERN Document Server

    Peccati, Francesca; González, Leticia

    2016-01-01

    5-Bromouracil is a nucleobase analogue that can replace thymine in DNA strands and acts as a strong radiosensitizer, with potential applications in molecular biology and cancer therapy. Here, the deactivation of 5-bromouracil after UV irradiation is investigated in the singlet and triplet manifold by accurate quantum chemistry calculations and nonadiabatic dynamics simulations. It is found that after irradiation to the bright 1pipi* state, three main relaxation pathways are in principle possible: relaxation back to the ground state, intersystem crossing, and C-Br photodissociation. Based on accurate MS-CASPT2 optimizations, we propose that ground state relaxation should be the predominant deactivation pathway in gas phase. We then employ different electronic structure methods to assess their suitability to carry out excited-state dynamics simulations. MRCIS was used in surface hopping simulations to compute the ultrafast intersystem crossing dynamics, which mostly involves the 1nOpi* and 3pipi* states.

  6. Incidência de infecção em pacientes com cateter peridural tunelizado Incidencia de infección en pacientes con cateter peridural tunelizado Infection incidence in patients with tunneled peridural catheter

    Directory of Open Access Journals (Sweden)

    Maria Cecilia Iksilara

    2005-04-01

    Full Text Available O cateter peridural tunelizado como via de administração de opiáceos vem sendo utilizado desde o início de 1980. Pacientes com dor crônica, que não obtêm alívio com medicamentos por outras vias, são muito beneficiados com infusão de opiáceo associado a um anestésico local por via peridural. Entretanto, ainda existem dúvidas sobre a eficácia do método, no manuseio e, conseqüentemente, quanto ao risco de infecção e outras complicações. Sendo a equipe de enfermagem fundamental para efetivar o tratamento para o alívio da dor, esse estudo propõe demonstrar como manter a técnica segura. Foram acompanhados 27 pacientes com dor crônica entre 2002 e 2004, que utilizaram o cateter peridural por 18 dias em média, implantados em nível torácico ou lombar. Não houve complicações como abcesso peridural, meningite ou hematoma peridural. A satisfação dos pacientes quanto a analgesia foi evidente.El cateter peridural tunelizado, como via de administración de opióides, es utilizado desde el comienzo de 1980. Pacientes con dolor crónico, que no tienen alivio con medicamentos por otras vias, son muy beneficiados con la administración de opióides, asociados a un anestésico local por via peridural. Sin embargo, aún existen dudas sobre la eficacia del método, en el manejo y, como consecuencia, en el riesgo de infección y otras complicaciones. Siendo el equipo de enfermería fundamental para ejecutar el tratamiento para alivio del dolor, esto estudio se propone a presentar como mantener la técnica segura. Vinte y siete pacientes con dolor crónica, entre 2002 a 2004, que utilizarón el cateter peridural por 18 dias en media, fuerón seguidos. Los cateteres fuerón implantados al nivele toracico o lumbar. No se presentaran complicaciones como absceso peridural, meningitis o hematoma peridural. La satisfacción de los pacientes quanto analgesia fué evidente.The tunneled epidural catheter as an administration access for opiates

  7. Environmental and health risks associated with reuse of wastewater for irrigation

    Directory of Open Access Journals (Sweden)

    Eman Shakir

    2017-03-01

    Full Text Available The present study focuses on the environmental and health risks associated with the use of treated wastewater produced from Al-Rustamia third extension plant for irrigation. The measured data are used to evaluate comprehensive pollution index (CPI and organic pollution index (OPI. The average CPI was found as 0.69 which indicated to be slightly polluted for all seasons and a similar result was also obtained with OPI, which is found to slightly vary in the range 1.29–1.60 which indicates as being to be contaminated. Also to evaluate its suitability for irrigation purposes, Sodium Adsorption Ratio (SAR, Soluble Sodium Percentage (SSP and Residual Sodium Carbonate (RSC were calculated following standard equations and found experimentally as (8.70, (74.76 and (2.68 respectively. Irrigation water classes are used for Salinity hazard (EC and Sodium hazard (SAR to assess water suitability for irrigation, and it is found that samples in summer and autumn in the class of C3-S1, indicate high salinity and low sodium water, while in spring and winter in the class of C4-S1, they indicate very high-salinity. Furthermore, the data indicate a slight to moderate degree of restriction on the use of this treated wastewater in irrigation due to chloride hazard. RSC value is more than 1.25 at all seasons, indicating that samples in summer and autumn are doubtful for irrigation purposes, while the samples in spring and winter are unsuitable for irrigation.

  8. Land-use intensification impact on phosphorus fractions in highly weathered tropical soils

    Science.gov (United States)

    Maranguit, Deejay; Guillaume, Thomas; Kuzyakov, Yakov

    2016-04-01

    Deforestation and land-use intensification in tropics have increased over the past decades, driven by the demand for agricultural products. Despite the fact that phosphorus (P) is one of the main limiting nutrients for agricultural productivity in the tropics, the effect of land-use intensification on P availability remains unclear. The objective was to assess the impacts of land-use intensification on soil inorganic and organic P fractions of different availability (Hedley sequential fractionation) and P stocks in highly weathered tropical soils. We compared the P availability under extensive land-use (rubber agroforest) and intensive land-use with moderate fertilization (rubber monoculture plantations) or high fertilization (oil palm monoculture plantations) in Indonesia. The phosphorus stock was dominated by inorganic forms (60 to 85%) in all land-use types. Fertilizer application increased easily-available inorganic P (i.e., H2O-Pi, NaHCO3-Pi) in intensive rubber and oil palm plantations compared to agroforest. However, the easily-available organic P (NaHCO3-extractable Po) was reduced by half under oil palm and rubber. The decrease of moderately available and non-available P by land-use intensification means that fertilization maintains only short-term soil fertility that is not sustainable in the long run due to the depletion of P reserves. The mechanisms of this P reserve depletion are: soil erosion (here assessed by C/P ratio), mineralization of soil organic matter (SOM) and export of P with yield products. Easily-available P fractions (i.e., H2O-Pi, NaHCO3-Pi and Po) and total organic P were strongly positively correlated with carbon content suggesting that SOM plays a critical role in maintaining P availability. Therefore, the ecologically based management is necessary in mitigating SOM losses to increase the sustainability of agricultural production in P limited highly weathered tropical soils.

  9. Estudio comparativo para el manejo del dolor en el reemplazo total de rodilla. [Comparative ­study­ for­ pain­ management ­in­ total­ knee ­replacement

    Directory of Open Access Journals (Sweden)

    César Pesciallo

    2015-01-01

    Full Text Available In­tro­duc­ción: El objetivo de este trabajo es comparar la infiltración intraoperatoria de los tejidos blandos periarticulares versus la utilización de bloqueos de los nervios periféricos (ciático y femoral para el manejo del dolor posoperatorio de la artroplastia total de rodilla. Materiales­ y ­Métodos: Se evaluaron, en forma prospectiva, 60 pacientes tratados, que fueron divididos en dos grupos iguales: grupo A, con infiltración intraoperatoria y grupo B, con bloqueo de los nervios femoral y ciático antes de la cirugía. Resultados: El dolor fue significativamente menor en el grupo B (bloqueados que en el grupo de control A (infiltrados entre las 4 y las 8 horas poscirugía (p = 0,008. Al segundo y al tercer días de la cirugía, la curva de dolor se invirtió y fue estadísticamente menor en el grupo A (p = 0,009 y p = 0,023, respectivamente. Conclusiones:­ Al evaluar los resultados se observó que ambos métodos fueron eficaces para el tratamiento del dolor posquirúrgico e, incluso, para disminuir el consumo de opiáceos. Los bajos niveles de dolor y el menor uso de opiáceos en el posoperatorio inmediato dieron lugar a una mejor rehabilitación y a un mayor bienestar general para el paciente.

  10. Indicators for wild animal offtake: methods and case study for African mammals and birds

    Directory of Open Access Journals (Sweden)

    Daniel J. Ingram

    2015-09-01

    Full Text Available Unsustainable exploitation of wild animals is one of the greatest threats to biodiversity and to millions of people depending on wild meat for food and income. The international conservation and development community has committed to implementing plans for sustainable use of natural resources and has requested development of monitoring systems of bushmeat offtake and trade. Although offtake monitoring systems and indicators for marine species are more developed, information on harvesting terrestrial species is limited. Building on approaches developed to monitor exploitation of fisheries and population trends, we have proposed two novel indicators for harvested terrestrial species: the mean body mass indicator (MBMI assessing whether hunters are relying increasingly on smaller species over time, as a measure of defaunation, by tracking body mass composition of harvested species within samples across various sites and dates; and the offtake pressure indicator (OPI as a measure of harvesting pressure on groups of wild animals within a region by combining multiple time series of the number of harvested individuals across species. We applied these two indicators to recently compiled data for West and Central African mammals and birds. Our exploratory analyses show that the MBMI of harvested mammals decreased but that of birds rose between 1966/1975 and 2010. For both mammals and birds the OPI increased substantially during the observed time period. Given our results, time-series data and information collated from multiple sources are useful to investigate trends in body mass of hunted species and offtake volumes. In the absence of comprehensive monitoring systems, we suggest that the two indicators developed in our study are adequate proxies of wildlife offtake, which together with additional data can inform conservation policies and actions at regional and global scales.

  11. The Elwha Science Education Project (ESEP): Engaging an Entire Community in Geoscience Education

    Science.gov (United States)

    Young, R. S.; Kinner, F.

    2008-12-01

    Native Americans are poorly represented in all science, technology and engineering fields. This under- representation results from numerous cultural, economic, and historical factors. The Elwha Science Education Project (ESEP), initiated in 2007, strives to construct a culturally-integrated, geoscience education program for Native American young people through engagement of the entire tribal community. The ESEP has developed a unique approach to informal geoscience education, using environmental restoration as a centerpiece. Environmental restoration is an increasingly important goal for tribes. By integrating geoscience activities with community tradition and history, project stakeholders hope to show students the relevance of science to their day-to-day lives. The ESEP's strength lies in its participatory structure and unique network of partners, which include Olympic National Park; the non-profit, educational center Olympic Park Institute (OPI); a geologist providing oversight and technical expertise; and the Lower Elwha Tribe. Lower Elwha tribal elders and educators share in all phases of the project, from planning and implementation to recruitment of students and discipline. The project works collaboratively with tribal scientists and cultural educators, along with science educators to develop curriculum and best practices for this group of students. Use of hands-on, place-based outdoor activities engage students and connect them with the science outside their back doors. Preliminary results from this summer's middle school program indicate that most (75% or more) students were highly engaged approximately 90% of the time during science instruction. Recruitment of students has been particularly successful, due to a high degree of community involvement. Preliminary evaluations of the ESEP's outcomes indicate success in improving the outlook of the tribe's youth towards the geosciences and science, in general. Future evaluation will be likewise participatory

  12. Oxime and atropine failure to prevent intermediate syndrome development in acute organophosphate poisoning

    Directory of Open Access Journals (Sweden)

    Vučinić Slavica

    2013-01-01

    Full Text Available Introduction. Intermediate syndrome (IMS was described a few decades ago, however, there is still a controversy regarding its exact etiology, risk factors, diagnostic parameters and required therapy. Considering that acute poisonings are treated in different types of medical institutions this serious complication of organophosphate insecticide (OPI poisoning is frequently overlooked. The aim of this paper was to present a case of IMS in organophosphate poisoning, which, we believe, provides additional data on the use of oxime or atropine. Case report. After a well-resolved cholinergic crisis, the patient developed clinical presentation of IMS within the first 72 h from deliberate malathion ingestion. The signs of IMS were weakness of proximal limb muscles and muscles innervated by motor cranial nerves, followed by the weakness of respiratory muscles and serious respiratory insufficiency. Malathion and its active metabolite were confirmed by analytical procedure (liquid chromatography-mass spectrometry. Pralidoxime methylsulphate, adiministered as a continuous infusion until day 8 (total dose 38.4 g, and atropine until the day 10 (total dose 922 mg did not prevent the development of IMS, hence the mechanical ventilation that was stopped after 27 h had to be continued until the day 10. Conclusion. Continuous pralidoxime methylsulphate infusion with atropine did not prevent the development of IMS, most likely due to the delayed treatment and insufficient oxime dose but also because of chemical structure and lipophilicity of ingested OPI. A prolonged intensive care monitoring and respiratory care are the key management for the intermediate syndrome. [Projekat Ministarstva nauke Republike Srbije, br. OI 176018, No. 46009

  13. Crash protectiveness to occupant injury and vehicle damage: An investigation on major car brands.

    Science.gov (United States)

    Huang, Helai; Li, Chunyang; Zeng, Qiang

    2016-01-01

    This study sets out to investigate vehicles' crash protectiveness on occupant injury and vehicle damage, which can be deemed as an extension of the traditional crash worthiness. A Bayesian bivariate hierarchical ordered logistic (BVHOL) model is developed to estimate the occupant protectiveness (OP) and vehicle protectiveness (VP) of 23 major car brands in Florida, with considering vehicles' crash aggressivity and controlling external factors. The proposed model not only takes over the strength of the existing hierarchical ordered logistic (HOL) model, i.e. specifying the order characteristics of crash outcomes and cross-crash heterogeneities, but also accounts for the correlation between the two crash responses, driver injury and vehicle damage. A total of 7335 two-vehicle-crash records with 14,670 cars involved in Florida are used for the investigation. From the estimation results, it's found that most of the luxury cars such as Cadillac, Volvo and Lexus possess excellent OP and VP while some brands such as KIA and Saturn perform very badly in both aspects. The ranks of the estimated safety performance indices are even compared to the counterparts in Huang et al. study [Huang, H., Hu, S., Abdel-Aty, M., 2014. Indexing crash worthiness and crash aggressivity by major car brands. Safety Science 62, 339-347]. The results show that the rank of occupant protectiveness index (OPI) is relatively coherent with that of crash worthiness index, but the ranks of crash aggressivity index in both studies is more different from each other. Meanwhile, a great discrepancy between the OPI rank and that of vehicle protectiveness index is found. What's more, the results of control variables and hyper-parameters estimation as well as comparison to HOL models with separate or identical threshold errors, demonstrate the validity and advancement of the proposed model and the robustness of the estimated OP and VP.

  14. Material Performance of Fully-Ceramic Micro-Encapsulated Fuel under Selected LWR Design Basis Scenarios: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    B. Boer; R. S. Sen; M. A. Pope; A. M. Ougouag

    2011-09-01

    The extension to LWRs of the use of Deep-Burn coated particle fuel envisaged for HTRs has been investigated. TRISO coated fuel particles are used in Fully-Ceramic Microencapsulated (FCM) fuel within a SiC matrix rather than the graphite of HTRs. TRISO particles are well characterized for uranium-fueled HTRs. However, operating conditions of LWRs are different from those of HTRs (temperature, neutron energy spectrum, fast fluence levels, power density). Furthermore, the time scales of transient core behavior during accidents are usually much shorter and thus more severe in LWRs. The PASTA code was updated for analysis of stresses in coated particle FCM fuel. The code extensions enable the automatic use of neutronic data (burnup, fast fluence as a function of irradiation time) obtained using the DRAGON neutronics code. An input option for automatic evaluation of temperature rise during anticipated transients was also added. A new thermal model for FCM was incorporated into the code; so-were updated correlations (for pyrocarbon coating layers) suitable to estimating dimensional changes at the high fluence levels attained in LWR DB fuel. Analyses of the FCM fuel using the updated PASTA code under nominal and accident conditions show: (1) Stress levels in SiC-coatings are low for low fission gas release (FGR) fractions of several percent, as based on data of fission gas diffusion in UO{sub 2} kernels. However, the high burnup level of LWR-DB fuel implies that the FGR fraction is more likely to be in the range of 50-100%, similar to Inert Matrix Fuels (IMFs). For this range the predicted stresses and failure fractions of the SiC coating are high for the reference particle design (500 {micro}mm kernel diameter, 100 {micro}mm buffer, 35 {micro}mm IPyC, 35 {micro}mm SiC, 40 {micro}mm OPyC). A conservative case, assuming 100% FGR, 900K fuel temperature and 705 MWd/kg (77% FIMA) fuel burnup, results in a 8.0 x 10{sup -2} failure probability. For a &apos

  15. Estudo comparativo entre cetorolaco e cetoprofeno no controle da dor pós-operatória de uvulopalatofaringoplastia A comparative study between Ketorolac and Ketoprofen in postoperative pain after uvulopalatopharyngoplasty

    Directory of Open Access Journals (Sweden)

    Lucas Gomes Patrocínio

    2007-06-01

    Full Text Available A dor no pós-operatório imediato apresenta-se como um grave problema, requerendo do médico uma adequada assistência. Na Otorrinolaringologia, merece atenção especial a dor após uvulopalatofaringoplastia (UPFP. OBJETIVO: Comparar a eficácia na analgesia pós-operatória do cetorolaco com o cetoprofeno em UPFP. PACIENTES E MÉTODOS: Estudo prospectivo, randomizado, duplo-cego com 24 pacientes submetidos à UPFP, divididos em 2 grupos, sendo que 14 receberam cetorolaco e 10 cetoprofeno. Avaliação da intensidade da dor através de escala visual analógica e necessidade do uso associado de opióide (tramadol. RESULTADOS: Dos 14 pacientes que receberam cetorolaco, apenas 3 (21% necessitaram uso complementar de opióide, enquanto que 7 (70% do grupo do cetoprofeno o fizeram. Após 12 horas de cirurgia, houve um predomínio de 71% dos pacientes que receberam cetorolaco, com dor leve ou até ausência desta, enquanto 70% dos do cetoprofeno referiram dor moderada ou incômoda. Após 24 horas de cirurgia, 60% dos pacientes que fizeram uso de cetoprofeno referiam dor moderada a incômoda, ao passo que 86% dos do cetorolaco referiram dor leve à ausência. CONCLUSÃO: Conclui-se que o cetorolaco é mais eficaz em relação ao cetoprofeno no tratamento da dor pós-operatória imediata de UPFP, pois houve dor de menor intensidade e menor uso de opióide.Postoperative pain is a serious problem, requiring an appropriate response from the medical doctor. In otolaryngology special attention is needed after uvulopalatopharyngoplasty (UP3. AIM: To compare the efficacy of postoperative analgesia using ketorolac and ketoprofen after UP3. PATIENTS AND METHODS: A prospective, randomized, double-blind study was made of 24 patients that were divided into 2 groups (14 received ketorolac and 10 received ketoprofen. Pain intensity was based on an analog visual scale and the need for opioids (tramadol. RESULTS: Of the 13 patients that received ketorolac, 3 (21

  16. The "oligoanalgesia problem" in the emergency care O "problema oligoanalgesia" no cuidado da emergência

    Directory of Open Access Journals (Sweden)

    Ana Maria Calil

    2007-01-01

    Full Text Available INTRODUCTION: Pain is a common occurrence in trauma victims that provokes harmful effects on the body. However, there is a gap in the literature about this problem, which is still underevaluated and undertreated in Brazil, especially concerning the use of opioids. OBJECTIVES: To estimate pain intensity and the use of analgesia in traffic accident victims. MATERIALS AND METHODS: A prospective study, involving 100 accident victims (traffic accidents, who were interviewed at 2 separate posttraumatic moments, in a reference hospital of the city of São Paulo. All the medications used for these victims were recorded. All patients displayed a Glasgow Coma Scale (ECGl of 15, had stable hemodynamic parameters, and were brought directly from the scene of the accident. RESULTS: Pain of moderate and severe intensity (in 90% of cases was the most noted. After a 3-hour period, a significant number of patients with pain (48% continued without analgesia, and few opioids were used. CONCLUSION: Pain is a common event associated with trauma. It is still undertreated and underevaluated in Brazil, and the use of opioids for admittedly very severe pain is not frequently employed in the Emergency Service even in hemodynamically stable patients and with a Glasgow Coma Scale of 15.INTRODUÇÃO: A dor é um evento comum em vítimas de trauma com efeitos nocivos ao organismo, no entanto, há uma lacuna na literatura sobre essa problemática ainda sub-avaliada e sub-tratada em nosso meio, sobretudo na utilização de opióides. OBJETIVOS: Aferir a intensidade dolorosa e o uso da analgesia em vítimas de acidentes de transportes. MATERIAL E MÉTODO: Estudo prospectivo, envolvendo 100 vítimas de causas externas (acidentes de transporte, que foram entrevistadas em dois momentos distintos pós-trauma em um hospital de referência no Município de São Paulo.. Foram anotadas todas as medicações em uso para essas vítimas. Todos os pacientes tinham Escala de Coma de Gasglow

  17. Associação de fentanil ou sufentanil à bupivacaína a 0,5% isobárica em raquianestesia: estudo comparativo

    Directory of Open Access Journals (Sweden)

    Neves José Francisco Nunes Pereira das

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Desde a descoberta dos receptores opióides e um maior entendimento da neurofarmacologia da medula espinhal em relação à transmissão e inibição do impulso nociceptivo, tem aumentado o interesse na utilização de drogas por via subaracnóidea, em Anestesiologia e tratamento da dor. O presente estudo tem como finalidade avaliar prospectivamente a eficácia clínica da adição de fentanil (25 µg e sufentanil (5 µg à bupivacaína isobárica (10 mg,em pacientes submetidos à raquianestesia para tratamento cirúrgico de varizes de MMII. MÉTODO: Participaram do estudo 60 pacientes, estado físico ASA I e II, com idades abaixo de 60 anos, submetidos à raquianestesia para tratamento cirúrgico de varizes e divididos aleatoriamente em três grupos: B (bupivacaína isobárica 10 mg, BF (bupivacaína isobárica 10 mg e fentanil 25 µg e BS (bupivacaína isobárica 10 mg e sufentanil 5 µg.A raquianestesia foi realizada em decúbito lateral esquerdo, punção lombar entre L3-L4, com agulha de Quincke 27G. Após a raquianestesia foram avaliados: tempo de latência, o nível de bloqueio sensitivo e bloqueio motor. No período per-operatório foram anotados: hipotensão arterial, bradicardia, depressão respiratória, diminuição da saturação periférica da hemoglobina pelo oxigênio, náuseas, vômitos, prurido e tremor. No período pós-operatório foi pesquisado o tempo de analgesia. RESULTADOS: Os grupos foram homogêneos. O tempo de latência, o bloqueio motor e o tempo de analgesia não apresentaram diferença significativa. O nível de bloqueio sensitivo mostrou diferença entre o grupo controle e os grupos contendo opióides em todos os momentos estudados. Prurido foi o efeito colateral mais freqüente nos grupos contendo opióides. CONCLUSÕES: A adição de fentanil (25 µg e sufentanil (5 µg à bupivacaína a 0,5% isobárica (10 mg em raquianestesia altera o nível de bloqueio sensitivo.

  18. Dosis efectiva de hidromorfona en pacientes con dolor crónico oncológico: experiencia de 4 años en el Centro Médico Nacional "20 de Noviembre" ISSSTE Effective dose of hydromorphone in patients with chronic oncologic pain: a four-year experience in the Centro Médico Nacional 20 de Noviembre, a public hospital in Mexico

    Directory of Open Access Journals (Sweden)

    E. Rionda

    2009-07-01

    Full Text Available Antecedentes: Aproximadamente 6,35 millones de nuevos casos de cáncer se diagnostican anualmente. El 90% de los pacientes con cáncer avanzado presentan dolor. El objetivo en el tratamiento del dolor oncológico es aliviar el dolor, interrumpiendo la transmisión o modulándolo a nivel cerebral o espinal. La Organización Mundial de la Salud (OMS desarrolló una escala de tres escalones para manejar el dolor oncológico. En el escalón I se incluyen analgésicos no opiáceos + coadyuvantes; en el escalón II se incluyen opiáceos leves + coadyuvantes y en el escalón III se incluyen opiáceos potentes + coadyuvantes. Material y métodos: Se revisaron 72 expedientes, en un total de 4 años, de todos los pacientes con dolor crónico oncológico que hayan estado en tratamiento con hidromorfona. En este trabajo obtuvimos la dosis promedio en la que se logró un buen control del dolor (escala analógica visual [EVA] Background: Approximately 6.35 million patients are diagnosed with cancer annually. Around 90% of patients with advanced cancer have pain. Treatment of oncologic pain aims to relieve pain by modulating or interrupting transmission in the spine or brain. The World Health Organization (WHO has developed a three-step ladder for cancer pain management. At step I, non-opioid plus adjuvant drugs are included. Step II includes opioids for mild to moderate pain plus adjuvants, and step III includes opioids for moderate to severe pain plus adjuvants. Material and methods: We reviewed 72 files corresponding to all the patients with chronic cancer pain that had been treated with hydromorphone during the previous 4 years in our hospital and calculated the mean dose at which the patients reported good pain control (Visual Analog Scale [VAS] < 4. We also studied the most common adverse effects, and whether any of the patients discontinued the treatment, and if so, the reasons for discontinuance. The type of cancer in each patient and the length

  19. Associação de fentanil ou sufentanil à bupivacaína a 0,5% isobárica em raquianestesia: estudo comparativo

    Directory of Open Access Journals (Sweden)

    José Francisco Nunes Pereira das Neves

    2002-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Desde a descoberta dos receptores opióides e um maior entendimento da neurofarmacologia da medula espinhal em relação à transmissão e inibição do impulso nociceptivo, tem aumentado o interesse na utilização de drogas por via subaracnóidea, em Anestesiologia e tratamento da dor. O presente estudo tem como finalidade avaliar prospectivamente a eficácia clínica da adição de fentanil (25 µg e sufentanil (5 µg à bupivacaína isobárica (10 mg,em pacientes submetidos à raquianestesia para tratamento cirúrgico de varizes de MMII. MÉTODO: Participaram do estudo 60 pacientes, estado físico ASA I e II, com idades abaixo de 60 anos, submetidos à raquianestesia para tratamento cirúrgico de varizes e divididos aleatoriamente em três grupos: B (bupivacaína isobárica 10 mg, BF (bupivacaína isobárica 10 mg e fentanil 25 µg e BS (bupivacaína isobárica 10 mg e sufentanil 5 µg.A raquianestesia foi realizada em decúbito lateral esquerdo, punção lombar entre L3-L4, com agulha de Quincke 27G. Após a raquianestesia foram avaliados: tempo de latência, o nível de bloqueio sensitivo e bloqueio motor. No período per-operatório foram anotados: hipotensão arterial, bradicardia, depressão respiratória, diminuição da saturação periférica da hemoglobina pelo oxigênio, náuseas, vômitos, prurido e tremor. No período pós-operatório foi pesquisado o tempo de analgesia. RESULTADOS: Os grupos foram homogêneos. O tempo de latência, o bloqueio motor e o tempo de analgesia não apresentaram diferença significativa. O nível de bloqueio sensitivo mostrou diferença entre o grupo controle e os grupos contendo opióides em todos os momentos estudados. Prurido foi o efeito colateral mais freqüente nos grupos contendo opióides. CONCLUSÕES: A adição de fentanil (25 µg e sufentanil (5 µg à bupivacaína a 0,5% isobárica (10 mg em raquianestesia altera o nível de bloqueio sensitivo.

  20. Los sectores institucionales en la producción científica española de difusión internacional

    Directory of Open Access Journals (Sweden)

    González–Albo, Borja

    2016-03-01

    Full Text Available Institutional sectors —groups of centers with similar characteristics and types of R&D— constitute an interesting unit of analysis that can also serve as a useful framework for benchmarking purposes in R&D studies. The analysis of Spanish scientific output included in the Web of Science database (2000–2011 shows the predominance of Universities (66%, followed by the Public Research Organisations (OPI (23% and the Health Sector (18%. Non–profit organizations (ESAL (10%, which include both Traditional Entities with non-Profit Aims (ETSAL and new Research Structures with non-Profit Aims (EISAL, show the highest impact values, regardless of whether indicators based on impact factors (normalised position, percentage of articles in the first quartile or on citations are used. Universities present a more evenly distributed thematic profile and it is the only sector specialized in fields such as Social Sciences, Humanities or Mathematics, while the Health Sector is highly specialized in Clinical Medicine. During the period studied, the different sectors tended to increase their scientific production, to publish in higher impact factor journals and to intensify the level of collaboration and internationalization of their publications. Especially noteworthy is the strong rise of non–profit organizations, in particular the case of EISAL, which conduct high impact research mainly in Biomedicine. No relationship has been found between the areas in which the sectors are specialized and those in which they obtain the highest impact.Los sectores institucionales, como agrupaciones de centros con características similares en su actividad y orientación a la investigación, constituyen una interesante unidad de análisis que puede servir además como marco de referencia en los estudios de I+D. El análisis de la producción científica de España (2000–2011 recogida en la base de datos Web of Science permite observar el predominio del sector

  1. Plasma and cerebrospinal fluid alfentanil, butorphanol, and morphine concentrations following caudal epidural administration in horses Concentrações plasmáticas e no líquido cérebro-espinhal de alfentanil, butorfanol e morfina após administração epidural caudal em eqüinos

    Directory of Open Access Journals (Sweden)

    Cláudio Corrêa Natalini

    2006-10-01

    Full Text Available This study was conducted with the objective of determining the plasma and cerebrospinal fluid (CSF concentrations after epidurally administered alfentanil, butorphanol, and morphine in horses. Five clinically healthy adult horses were studied. Morphine 0.1mg kg-1, alfentanil 0.02mg kg-1, and butorphanol 0.08mg kg-1 in equal volumes (20ml were epidurally injected. A 10-ml sample of CSF and blood were drawn at sampling times before the epidural administration and at 5, 10, 20, 30, 40, 50, 60 and 120 minutes, and hourly for 24 hours Enzyme-linked immonosorbent assay (ELISA was used as the screening test to detect the injected opioids. ANOVA and Bonferroni’s test were used with a P values Este estudo foi realizado com o objetivo de se detectar as concentrações plasmáticas e no líquido cérebro-espinhal de alfentanil, butorfanol e morfina administrados por via epidural caudal em cavalos. Foram utilizados cinco eqüinos adultos, clinicamente hígidos. Doses de morfina (0,1mg kg-1, alfentanil (0,02mg kg-1, e butorfanol (0,08mg kg-1, diluídos em volume idêntico de 20ml em solução salina 0,9%, foram administrados por via epidural. Uma amostra de 10ml de sangüe venoso e de líqüido cérebro-espinhal foram colhidas anteriormente à administração epidural e 5, 10, 20, 30, 40, 50, 60 e 120 minutos e a cada hora por 24 horas. O teste enzyme-linked immunosorbent assay (ELISA foi utilizado como método analítico para detecção dos opióides. Os resultados foram avaliados com teste ANOVA e Bonferroni com valor de P<0,05. O teste de ELISA mostrou-se eficiente para detecção plasmática e no LCE de alfentanil, butorfanol, e morfina administrados por via epidural. A administração epidural de alfentanil em eqüinos produz níveis no líquido cérebro-espinhal mais rapidamente que no plasma. Opióides de maior hidrossolubilidade tais como morfina e butorfanol produzem níveis plasmáticos mais rapidamente do que no líquido cérebro-espinhal quando

  2. The effect of a hydrological model structure and rainfall data on the accuracy of flood description in an upland catchment

    Directory of Open Access Journals (Sweden)

    Wałęga Andrzej

    2015-12-01

    Full Text Available Wpływ struktury modelu i danych opadowych na dokładność opisu wezbrań na przykładzie zlewni wyżynnej. Celem pracy było określenie wpływu struktury modelu hydrologicznego i jakości danych opadowych na parametry wezbrań uzyskane z symulacji. Badania prowadzono w zlewni rzeki Stobnicy - prawostronnego dopływu Wisłoka. Przyjęto następujące założenia: wzrost liczby stacji opadowych pozwala na dokładniejszy opis przebiegu wezbrania przez model oraz model o parametrach rozłożonych pozwala na dokładniejszy opis reakcji zlewni na opad niż model o parametrach skupionych. Obliczenia prowadzono w programie HEC-HMS 3.4. Analizy wykazały, że zwiększenie liczby stacji opadowych nieznacznie poprawia jakość pracy modelu (w przypadku uwzględnienia większej liczby stacji opadowych w modelu współczynnik efektywności wzrósł średnio o 4,1%. Ponadto wykazano, że w przypadku zlewni o nieznacznym zróżnicowaniu warunków topograficznych i użytkowania lepsze wyniki symulacji wezbrań uzyskano dla modelu o parametrach skupionych w porównaniu do modelu o parametrach rozłożonych. Uwzględnienie dodatkowo procesu kalibracji nieznacznie poprawiło jakość pracy modelu niezależnie od jego struktury i ilości stacji opadowych. Wieloczynnikowa analiza wariancji MANOVA wykazała, że uzyskane różnice w efektywności pracy modelu dla różnych wariantów nie były statystycznie istotne. Ze względu na ograniczony materiał empiryczny dotyczący epizodów opad-odpływ, uzyskane wyniki mogą być obdarzone znaczną niepewnością i należy traktować je jako przyczynek do dalszych badań.

  3. TMSR硝酸盐自然循环回路控制系统设计%Design of nitrate natural circulation loop control system in TMSR

    Institute of Scientific and Technical Information of China (English)

    张宁; 郭冰; 韩立欣; 周大勇

    2015-01-01

    Background: Nitrate natural circulation loop (NNCL) is one of experimental platform in thorium-based molten salt reactor (TMSR), which was designed to study the heat transfer behavior and corrosion behavior of direct reactor auxiliary cooling system (DRACS).Purpose: This study aims to implement a distributed control system (DCS) with functionalities of system control, online state monitor and experimental data acquisition in NNCL. Methods: An experimental physics and industrial control system (EPICS) based distributed control system was designed for this project. An optimized support module structure was designed for I/O operation with low-level PLCs to improve the performance of input/output controller (IOC) runtime database, and a PostgreSQL database was employed for data archive by RDB ChannelArchiver. A control system studio (CSS) interface and MATLAB was implemented in operator interface (OPI) computers, for visual operation and experimental data calculation.Results: Testing for online operation and history data acquisition in OPI interface proved that the control system satisfied all requirements of NNCL control and state monitor with long-term effective.Conclusion: The system could provide efficient and reliable routine for online operation and would well support advanced study of DRACS on this NNCL platform.%为了对硝酸盐自然循环回路(Nitrate Natural Circulation Loop, NNCL)的各子系统及设备的运行状态进行在线监测及远程控制,设计并实现了具有分布式结构的控制系统,并根据工程实际对其软件模块进行了改进。主要包括对过程控制软件包进行结构优化,以提高多通道模式下数据传输效率;使用PostgreSQL关系型数据库取代本地数据存储方式进行数据存档管理和和查询;在操作员计算机中更新人机界面软件以获得更好的界面效果,配置MATLAB在线驱动接口用于数据在线处理。经过运行测试表明,此系统可长期有

  4. Ação central do naloxone sobre as ß-endorfinas e hormônio luteinizante (LH em ovelhas ovariectomizadas e hipoglicêmicas

    Directory of Open Access Journals (Sweden)

    Angela Maria Xavier Eloy

    1999-01-01

    Full Text Available Com a finalidade de se investigar o efeito no Sistema Nervoso Central (SNC do opióide antagonista naloxone hidrocloride sobre a liberação do hormônio luteinizante (LH em ovelhas ovariectomizadas e hipoglicêmicas, utilizaram-se oito fêmeas mestiças oriundas das raças Mule e Suffolk, pesando 65,7 ± 3,6 kg. Duas semanas antes do início dos trabalhos, os animais foram canulados bilateralmente nos ventrículos. Foram feitos dois tratamentos (TI- animais não-estressados; TII- animais estressados, que foram subdivididos em três grupos (solução salina, 1 mg e 2 mg de naloxone. Os animais foram distribuídos, aleatoriamente, dentro das parcelas e foram feitas repetições com intervalo de uma semana, até que se alcançassem quatro observações por tratamento. No TI não se observou alteração nas concentrações de ß-endorfinas e LH, enquanto no TII, apesar de os animais não apresentarem alterações nos níveis de ß-endorfinas após injeção intracerebroventricular (i.c.v. de 1 mg de naloxone, observou-se diminuição significativa (p<0,05 após injeção (i.c.v. de 2 mg. No TII, as concentrações de LH aumentaram significativamente (p<0,05 após injeção (i.c.v. de 1 e 2 mg de naloxone. Conclui-se, portanto, que mesmo na ausência dos esteróides gonadais, os opióides endógenos estão envolvidos no controle do LH em animais hipoglicêmicos.

  5. Epistatic roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes.

    Directory of Open Access Journals (Sweden)

    Konstantin A Tsetsarkin

    Full Text Available Between 2005 and 2007 Chikungunya virus (CHIKV caused its largest outbreak/epidemic in documented history. An unusual feature of this epidemic is the involvement of Ae. albopictus as a principal vector. Previously we have demonstrated that a single mutation E1-A226V significantly changed the ability of the virus to infect and be transmitted by this vector when expressed in the background of well characterized CHIKV strains LR2006 OPY1 and 37997. However, in the current study we demonstrate that introduction of the E1-A226V mutation into the background of an infectious clone derived from the Ag41855 strain (isolated in Uganda in 1982 does not significantly increase infectivity for Ae. albopictus. In order to elucidate the genetic determinants that affect CHIKV sensitivity to the E1-A226V mutation in Ae. albopictus, the genomes of the LR2006 OPY1 and Ag41855 strains were used for construction of chimeric viruses and viruses with a specific combination of point mutations at selected positions. Based upon the midgut infection rates of the derived viruses in Ae. albopictus and Ae. aegypti mosquitoes, a critical role of the mutations at positions E2-60 and E2-211 on vector infection was revealed. The E2-G60D mutation was an important determinant of CHIKV infectivity for both Ae. albopictus and Ae. aegypti, but only moderately modulated the effect of the E1-A226V mutation in Ae. albopictus. However, the effect of the E2-I211T mutation with respect to mosquito infections was much more specific, strongly modifying the effect of the E1-A226V mutation in Ae. albopictus. In contrast, CHIKV infectivity for Ae. aegypti was not influenced by the E2-1211T mutation. The occurrence of the E2-60G and E2-211I residues among CHIKV isolates was analyzed, revealing a high prevalence of E2-211I among strains belonging to the Eastern/Central/South African (ECSA clade. This suggests that the E2-211I might be important for adaptation of CHIKV to some particular conditions

  6. Epistatic roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes.

    Science.gov (United States)

    Tsetsarkin, Konstantin A; McGee, Charles E; Volk, Sara M; Vanlandingham, Dana L; Weaver, Scott C; Higgs, Stephen

    2009-08-31

    Between 2005 and 2007 Chikungunya virus (CHIKV) caused its largest outbreak/epidemic in documented history. An unusual feature of this epidemic is the involvement of Ae. albopictus as a principal vector. Previously we have demonstrated that a single mutation E1-A226V significantly changed the ability of the virus to infect and be transmitted by this vector when expressed in the background of well characterized CHIKV strains LR2006 OPY1 and 37997. However, in the current study we demonstrate that introduction of the E1-A226V mutation into the background of an infectious clone derived from the Ag41855 strain (isolated in Uganda in 1982) does not significantly increase infectivity for Ae. albopictus. In order to elucidate the genetic determinants that affect CHIKV sensitivity to the E1-A226V mutation in Ae. albopictus, the genomes of the LR2006 OPY1 and Ag41855 strains were used for construction of chimeric viruses and viruses with a specific combination of point mutations at selected positions. Based upon the midgut infection rates of the derived viruses in Ae. albopictus and Ae. aegypti mosquitoes, a critical role of the mutations at positions E2-60 and E2-211 on vector infection was revealed. The E2-G60D mutation was an important determinant of CHIKV infectivity for both Ae. albopictus and Ae. aegypti, but only moderately modulated the effect of the E1-A226V mutation in Ae. albopictus. However, the effect of the E2-I211T mutation with respect to mosquito infections was much more specific, strongly modifying the effect of the E1-A226V mutation in Ae. albopictus. In contrast, CHIKV infectivity for Ae. aegypti was not influenced by the E2-1211T mutation. The occurrence of the E2-60G and E2-211I residues among CHIKV isolates was analyzed, revealing a high prevalence of E2-211I among strains belonging to the Eastern/Central/South African (ECSA) clade. This suggests that the E2-211I might be important for adaptation of CHIKV to some particular conditions prevalent in

  7. Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients.

    Science.gov (United States)

    Maes, M; Christophe, A; Delanghe, J; Altamura, C; Neels, H; Meltzer, H Y

    1999-03-22

    Depression is associated with a lowered degree of esterification of serum cholesterol, an increased C20:4omega6/C20:5omega3 ratio and decreases in omega3 fractions in fatty acids (FAs) or in the red blood cell membrane. The aims of the present study were to examine: (i) serum phospholipid and cholesteryl ester compositions of individual saturated fatty acids (SFAs), monounsaturated FAs (MUFAs) and polyunsaturated FAs (PUFAs) in major depressed patients vs. healthy volunteers; (ii) the relationships between the above FAs and lowered serum zinc (Zn), a marker of the inflammatory response in depression; and (iii) the effects of subchronic treatment with antidepressants on FAs in depression. The composition of the FAs was determined by means of thin layer chromatography in conjunction with gas chromatography. Lipid concentrations were assayed by enzymatic colorimetric methods. The oxidative potential index (OPI) of FAs was computed in 34 major depressed inpatients and 14 normal volunteers. Major depression was associated with: increased MUFA and C22:5omega3 proportions and increased C20:4omega6/C20:5omega3 and C22:5omega6/C22:6omega3 ratios; lower C22:4omega6, C20:5omega3 and C22:5omega3 fractions in phospholipids; lower C18:3omega3, C20:5omega3 and total (sigma)omega3 FAs, and higher C20:4omega6/C20:5omega3 and sigmaomega6/sigmaomega3 ratios in cholesteryl esters; lower serum concentrations of phospholipids and cholesteryl esters; and a decreased OPI. In depression, there were significant and positive correlations between serum Zn and C20:5omega3 and C22:6omega3 fractions in phospholipids; and significant inverse correlations between serum Zn and the sigmaomega6/sigmaomega3, C20:4omega6/C20:5omega3, and C22:5omega6/C22:6omega3 ratios in phospholipids. There was no significant effect of antidepressive treatment on any of the FAs. The results show that, in major depression, there is a deficiency of omega3 PUFAs and a compensatory increase in MUFAs and C22:5omega6 in

  8. Tratamiento del dolor en el paciente oncológico Treatment of pain in the oncology patient

    Directory of Open Access Journals (Sweden)

    A.M. Araujo

    2004-01-01

    Full Text Available El dolor es un síntoma de alta prevalencia en los pacientes con cáncer y deteriora de forma importante su calidad de vida. Con las medidas enunciadas por la OMS en 1986, que divide en tres escalones ascendentes las distintas opciones terapéuticas de las que disponemos, el dolor puede ser controlado en un alto porcentaje de casos. Aquellos pacientes difíciles de controlar con estas medidas, se pueden beneficiar de la aplicación de técnicas de neuromodulación por expertos en el tratamiento del dolor crónico. El correcto manejo de los distintos fármacos (AINES, opiáceos y coadyuvantes, el conocimiento de sus efectos secundarios, la pérdida del miedo a los opiáceos y el conocimiento de los distintos síndromes álgicos asociados al paciente oncológico, deben ir de la mano con la adecuada valoración del dolor según las distintas escalas, tanto en la fase de instauración del tratamiento, como en el seguimiento del paciente.Pain is a symptom with a high prevalence in patients with cancer and causes an important deterioration in their quality of life. With the measures laid out by the WHO in 1986, which divides the different therapeutic options available in three ascending steps, pain can be controlled in a high percentage of cases. Those patients who are difficult to control with these measures can benefit from the application of neuromodulation techniques by experts in the treatment of chronic pain. The correct employment of the different medicines (non-steroidal anti-inflammatory medicines, opiates and coadjuvants, knowledge of the secondary effects, loss of fear in the face of opiates and knowledge of the different algic syndromes associated with the oncology patient, must be accompanied by a suitable evaluation of the pain according to the different scales, both in the phase of the treatment’s initiation and in the follow-up of the patient.

  9. Desarrollo tecnológico y estudio de estabilidad del citrato de fentanilo 0,05 mg/mL Technological development and stability study of fentanyl citrate 0.05 mg/mL

    Directory of Open Access Journals (Sweden)

    Alejandro Saúl Padrón Yaqui

    2004-12-01

    Full Text Available El citrato de fentanilo es un potente analgésico opiácico, análogo sintético de la morfina, que se emplea ampliamente como anestésico narcótico en cirugía durante la premedicación y mantenimiento de la anestesia, y el período posoperatorio. Se desarrolló una formulación de citrato de fentanilo para administración por vía parenteral. Se obtuvo un medicamento que cumple con todos los requisitos de calidad exigidos y tiene un tiempo de vida útil de 2 años, a temperatura ambiente, que mantiene invariables sus características físicas, químicas y microbiológicas.Fentanyl citrate is a poweful opiatic analgesic, a synthetic analogue of morphine, which is widely used as narcotic analgesic in surgery preoperativey, during surgery and postoperativey.. A fentanyl citrate formulation to be parenterally administered was developed. The resulting drug fulfills all the quality requeriments and has a useful lifetime of two years, at room temperature, and keeps its physical, chemical and microbiological features unchanged.

  10. Post-irradiation examination of capsule P13T

    Energy Technology Data Exchange (ETDEWEB)

    Scheffel, W.J.

    1981-08-01

    Postirradiation examination revealed excellent performance of the H-451 and TS-1240 graphite bodies and fuel rods irraidated to a peak fluence of 8.0 x 10/sup 25/ n/m/sup 2/ (E > 29 fJ)/sub HTGR/ and to a peak volume-average fuel rod temperature of 1215/sup 0/C. A range of fuel rod variables was tested matrix filler graphite, shim particles, compositions; no variable was detrimental to the rod integrity. Particle batches with coating designs representative of the LHTGR (Large HTGR) design requirements exhibited fair irradiation performance to full fast neutron exposure ((8.0 x 10/sup 25/ n/m/sup 2/) (E > 29 fJ)/sub HTGR/) and burnups of 75%. True in-service particle failures were concluded to be <0.3% for all P13T particles. The observed failure was attributed to the outer pyrolytic carbons (OPyC) layer. The failure fraction for 32 P13T fuel rods are greater than predicted, but the mean observed value is less than predicted up to fast fluences of approx. 6.0 x 10/sup 25/ n/m/sup 2/ (E > 29 fJ)/sub HTGT/ at 50% confidence. Incipient degradation of the SiC coating due to palladium attack was observed in the HEU UC/sub 2/-TRISO and the UCO (oxygen/uranium ratio (O/U) = 0.64) fuel rods.

  11. PERCEPCIÓN DE LOS ESTUDIANTES DE UNA EXPERIENCIA DE USO DIDÁCTICO DE BLOG DOCENTE EN EDUCACIÓN SUPERIOR

    Directory of Open Access Journals (Sweden)

    J. Pere Molina Alventosa

    2016-01-01

    Full Text Available En este trabajo se estudia la percepción de los estudiantes de una experien - cia en el uso didáctico de un blog docente durante cuatro cursos académicos en una asignatura universitaria. Los datos se recogieron a través de las con - testaciones de los estudiantes a un post del blog donde se les solicitaba que realizasen una valoración del mismo. A través de un análisis cualitativo se definieron cinco categorías: el blog como herramienta de innovación educati - va, el blog como recurso de organización flexible e hipertextual, el blog como entorno de aprendizaje participativo, el blog como agente de cambio del rol docente y propuestas de mejora. Los resultados ponen de manifiesto una opi - nión favorable del alumnado en cuanto al uso del blog, ya que lo consideran un recurso motivador que les permite ampliar y profundizar en los conteni - dos de la asignatura gracias a sus múltiples utilidades y a las posibilidades de interacción y comunicación que ofrece. La disponibilidad permanente del blog permite acercar la asignatura a los estudiantes y sus posibilidades parti - culares de aprendizaje, permitiendo también la comunicación tanto entre el profesor y el alumnado como entre estos últimos.

  12. Eficacia y tolerancia de la pregabalina en el tratamiento del dolor neuropático: Estudio multicéntrico Efficacy and safety of pregabalin in neuropathic pain: Multicenter study

    Directory of Open Access Journals (Sweden)

    V. De Sanctis-Briggs

    2011-10-01

    Full Text Available Introducción: Se pretendió evaluar la eficacia y tolerabilidad de la pregabalina, para el tratamiento del dolor neuropático en las Unidades de Dolor hospitalarias. Material y método: Estudio prospectivo, multicéntrico, abierto, que se llevó a cabo en 10 unidades del dolor de hospitales de Cataluña. Se prescribió pregabalina, a criterio del facultativo, de manera consecutiva. Criterios de inclusión: consentimiento, dolor neuropático, mayor de edad y paciente externo. Criterios de exclusión: alteraciones cognitivas, embarazo. Se estipularon 5 visitas: basal, 15 días, 1 mes, 2 y 3 meses de tratamiento. La titulación de las dosis de pregabalina estaba preespecificada. Se registró edad, sexo, tipo de dolor neuropático, EVA (basal, 15 días, 1 mes, 2 meses, 3 meses, escala MOS de sueño (basal y tercer mes, tratamiento farmacológico concomitante y episodios de efectos adversos. Se crearon 3 grupos de estudio: pregabalina + antiinflamatorios no esteroideos (AINE + antidepresivos tricíclicos (AINE + ATC, pregabalina + AINE + ansiolíticos (AINE + ANS, pregabalina + AINE + opioides (AINE + OPI. Se efectuó prueba paramétrica t de Student y test no paramétrico de Wilcoxon para datos apareados de variables cuantitativas. Resultados: Se reclutaron 578 pacientes de los que 472 (81,66% completaron el estudio. El 98,8% recibieron politerapia. El alivio del dolor registró una media de -3,6 (± 1,9 (p Aim and objective: This study was intended to avaluate the efficacy and tolerability of pregabalin in patients with neuropathic pain and concomitant medication. Material and methods: Investigator-initiated, prospective multicenter study, open-label, uncontrolled conducted in 10 pain units from Catalonia hospitals. Pregabalin was consecutively prescribed at the physicians' discretion to avoid selective bias. Inclusion criteria were: outpatient, age >18 years, admission diagnosis as "neuropathic pain" and informed consent. Exclusion criteria were

  13. Sintaksa, semantika, pragmatika u istro romanskim tekstovima: o nekim zanimljivim slučajevima višeznačnosti

    Directory of Open Access Journals (Sweden)

    Pavao Tekavčić

    1988-12-01

    Full Text Available U prilogu se, u okviru projekta studija suvremenih istroromanskih (prvenstveno rovinjskih tekstova, proučavaju primjeri dvo- ili višeznačnosti rečenica. Uz primjere uvijek se daje i potrebni opis situacije, jer situacija i/ili kontekst redovito omogučuju pravilno razumijevanje a tirne i razrješavaju višeznačnost (pa višeznačnosti redovito i nema kad rečenica biva »uronjena« u kontekst i/ili situaciju postajući tako iskaz. Većina analiziranih primjera dopušta dvije ili tri interpretacije (»čitanja«, neki i više (čak do pet. Po vrstama rečenica najčešće su pogodbene, zatim odnosne pa neki drugi tipovi. Višeznačnost je večinom na sintaktičkoj, samo u nekim malobrojnim primjerima na morfološkoj ili fonetskoj razini. Razrješenje višeznačnosti moguće je u velikoj večini primjerâ, zahvaljujući pragmatičkim i/ili tekstovnim faktorima; kada to nije moguće, specifično lingvistička sredstva ne mogu pomoći, što dokazuje superiornost pragmalingvističkih i tekstovnih faktora u funkcioniranju jezika.

  14. On internal definite reference in Slavic languages

    Directory of Open Access Journals (Sweden)

    Piper Predrag J.

    2014-01-01

    Full Text Available The considered examples of use of the “such and such“ type of expression in Serbian and other Slavic languages and their analysis show that they represent a special type of reference and hold a special place in the system of pronominal words and expressions. Regardless of the fact that they can take a variety of functions, which are discussed in the article, their main function is to refer to what is determined for participants in a primary communicative situation, denoted by an utterance within an utterance, but which is undetermined for participants in a secondary communicative situation (with the exception of cases of same participants being involved in both primary and secondary situations. The forms of expressing internal definite reference are not entirely the same in all Slavic languages, although reduplication of pronominal demonstrative prevails with a high degree of match in their functions. The highest match is found when performing their main function of internal definite reference, while the lowest match is found when performing the function of euphemistic replacement of invective. [Projekat Ministarstva nauke Republike Srbije, br. 178021: Opis i standardizacija savremenog srpskog jezika

  15. OPINIÓN DE LOS ESTUDIANTES DE PSICOLOGÍA SOBRE LA INCLUSIÓN DE ACTIVIDADES DEPORTIVAS Y CULTURALES EN SU FORMACIÓN PROFESIONAL

    Directory of Open Access Journals (Sweden)

    Berenice Orozco Lagunas

    2015-01-01

    Full Text Available Según la Asociación Nacional de Universidades e Instituciones de Educación Superior, la univer - sidad debe brindar una formación integral y profesional, preparar en alguna disciplina científica y ofrecer actividades complementarias. Por ello, el objetivo de esta investigación fue conocer la opi - nión de estudiantes de Psicología de la Universidad del Estado de Morelos respecto a actividades extracurriculares en su formación. Participaron cien estudiantes regulares de diversos semestres, a quienes se aplicó un cuestionario de once preguntas para conocer su opinión acerca de las activi - dades extracurriculares y su tiempo libre. Los resultados muestran que una parte considerable del alumnado gozaba de tiempo libre por semana, manifestando interés en participar en dichas activi - dades y apoyando la implementación de estas en el currículo profesional. Los autores concluyen que es importante incluir las actividades deportivas y culturales en el plan de estudios, pues dotan de herramientas cognitivas y reportan importantes beneficios físicos en la formación de los estudiantes.

  16. Development of a Radial Deconsolidation Method

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Montgomery, Fred C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-12-01

    A series of experiments have been initiated to determine the retention or mobility of fission products* in AGR fuel compacts [Petti, et al. 2010]. This information is needed to refine fission product transport models. The AGR-3/4 irradiation test involved half-inch-long compacts that each contained twenty designed-to-fail (DTF) particles, with 20-μm thick carbon-coated kernels whose coatings were deliberately fabricated such that they would crack under irradiation, providing a known source of post-irradiation isotopes. The DTF particles in these compacts were axially distributed along the compact centerline so that the diffusion of fission products released from the DTF kernels would be radially symmetric [Hunn, et al. 2012; Hunn et al. 2011; Kercher, et al. 2011; Hunn, et al. 2007]. Compacts containing DTF particles were irradiated at Idaho National Laboratory (INL) at the Advanced Test Reactor (ATR) [Collin, 2015]. Analysis of the diffusion of these various post-irradiation isotopes through the compact requires a method to radially deconsolidate the compacts so that nested-annular volumes may be analyzed for post-irradiation isotope inventory in the compact matrix, TRISO outer pyrolytic carbon (OPyC), and DTF kernels. An effective radial deconsolidation method and apparatus appropriate to this application has been developed and parametrically characterized.

  17. BADANIE MIESZANEK MINERALNO-ASFALTOWYCH W WARUNKACH ŚCINANIA PRZY KONTROLOWANEJ SZTYWNOŚCI WZDŁUŻNEJ

    Directory of Open Access Journals (Sweden)

    Adam ZOFKA

    2016-07-01

    Full Text Available W artykule przedstawiono koncepcję nowej metody badania próbek z mieszanki mineralno-asfaltowej w warunkach ścinania z ciśnieniem bocznym. Dotychczas stosowane metody badawcze ścinania z obciążeniem bocznym opierają się na ocenie właściwości mieszanki mineralno-asfaltowej przy ścinaniu w warunkach stałej siły wzdłużnej lub stałej objętości badanej próbki. Nowa metoda badawcza pozwala na badanie ścinania przy stałej sztywności wzdłużnej. Aby możliwe było badanie według tej metody, zaprojektowano i wykonano specjalną przystawkę o nazwie AST (ang. Advanced Shear Tester. W artykule przedstawiono zarówno opis procesu twórczego podczas projektowania przystawki, jak wykonane urządzenie. Zaprezentowano pierwsze wyniki badań walidacyjnych uzyskanych przy użyciu przystawki na próbkach UHMW-PE oraz z mieszanki mineralno-asfaltowej.

  18. An Estimation of Gas Pressure in a TRISO of 350 MWth Block-Type HTR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Min; Jo, C. K.; Cho, M. S. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    An estimation of gas pressure in a TRISO with a UCO kernel has been performed under the normal operation conditions of a HTR. The following conclusions are drawn through the analysis. - The major gas species is xenon below 1000 .deg. C, and cesium starts to significantly build up between 1000 and 1100 .deg. C. - The lower the PF is, the earlier cesium gas begins to form and the higher the total gas pressure is. - The total gas pressure in a TRISO is about 28 MPa at temperature of 1300 .deg. C, PF of 25%, and EFPD of 1500. - The low PF is desirable on fuel economy. The analyses of stress and failure of TRISOs will be used to determine whether the pressures are tolerable or not. The HTR will be operated for an extended fuel burnup of more than 150 GWd/MTU. Its fuel should survives the long irradiation. The block-type HTR fuel is a cylindrical graphite compact in which a large number of tri-isotropic coated fuel particles (TRISOs) are embedded. A TRISO consists of a kernel at its central region and four coating layers surrounding the kernel: buffer, IPyC (inner pyrocarbon), SiC (silicon carbide), and OPyC (outer pyrocarbon), from the inside. In a usual UO{sub 2} TRISO, a very high gas pressure builds up due to the extended operation of a HTR. Nuclear fissions in a kernel produces free oxygen.

  19. Trabajadores agrícolas y subjetividad en California

    Directory of Open Access Journals (Sweden)

    Florencio Posadas Segura

    2014-01-01

    Full Text Available En este trabajo se explora el problema de la subjetividad de los trabajadores agríco - las, partiendo de la hipótesis de que éstos consideran malas sus condiciones de vida y de trabajo. Mediante el trabajo de campo se demostraron sus conocimientos y opi - niones sobre su situación laboral y existencial en el Valle de San Joaquín California durante 2007 y 2008. Se descubrió que la visión del trabajador agrícola está basada en la subjetivación y reinterpretación de sus circunstancias objetivas de trabajo y de vida. Se concluyó que los trabajadores agrícolas opinan que sus condiciones son pé - simas porque sus derechos laborales, sociales y humanos no se reconocen o respetan, la crisis económica, social y política de Estados Unidos les perjudica y el Tratado de Libre Comercio entre México, Estados Unidos y Canadá ( TLCAN sólo podría beneficiarles con una reforma migratoria.

  20. Phosphatidic acid and phosphoinositides facilitate liposome association of Yas3p and potentiate derepression of ARE1 (alkane-responsive element one)-mediated transcription control.

    Science.gov (United States)

    Kobayashi, Satoshi; Hirakawa, Kiyoshi; Horiuchi, Hiroyuki; Fukuda, Ryouichi; Ohta, Akinori

    2013-12-01

    In the n-alkane assimilating yeast Yarrowia lipolytica, the expression of ALK1, encoding a cytochrome P450 that catalyzes terminal mono-oxygenation of n-alkanes, is induced by n-alkanes. The transcription of ALK1 is regulated by a heterocomplex that comprises the basic helix-loop-helix transcription activators, Yas1p and Yas2p, and binds to alkane-responsive element 1 (ARE1) in the ALK1 promoter. An Opi1 family transcription repressor, Yas3p, represses transcription by binding to Yas2p. Yas3p localizes in the nucleus when Y. lipolytica is grown on glucose but localizes to the endoplasmic reticulum (ER) upon the addition of n-alkanes. In this study, we showed that recombinant Yas3p binds to the acidic phospholipids, phosphatidic acid (PA) and phosphoinositides (PIPs), in vitro. The ARE1-mediated transcription was enhanced in vivo in mutants defective in an ortholog of the Saccharomyces cerevisiae gene PAH1, encoding PA phosphatase, and in an ortholog of SAC1, encoding PIP phosphatase in the ER. Truncation mutation analyses for Yas3p revealed two regions that bound to PA and PIPs. These results suggest that the interaction with acidic phospholipids is important for the n-alkane-induced association of Yas3p with the ER membrane.

  1. Comprehensive evaluation of future site alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Shain, D.I.; Jones, M.E.; Ryan, K.

    1994-04-01

    Due to rapid changes occurring within the Nuclear Weapons complex, the need for integrated planning designed to combine multiple program needs into one strategic plan has become a necessity. This is more apparent as diverse DOE programs compete for dwindling resources. These programs range from traditional production operations, environmental and waste management, to facility transition, economic development, decontamination and decommissioning, and environmental restoration activities. Each program can influence another, thus increasing the difficulty of distinguishing program elements. The method in developing comprehensive plans becomes even more complicated when environmental compliance issues, regulatory agreements and stakeholder values are considered. AT the Department of Energy`s (DOE) Rocky Flats Plant (RFP), all of these program conditions exist. This paper addresses a set of tools which are being developed at RFP that provides key planning elements and alternatives assessment for the DOE`s Office of Planning and Integration (OPI) and National Environmental Policy Act (NEPA) Compliance Officer at RFP. This set of tools is referred to as the Systems Engineering Analysis (SEA).

  2. Dwa przypadki scleromyxedema

    Directory of Open Access Journals (Sweden)

    Jadwiga Dwilewicz-Trojaczek

    2011-01-01

    Full Text Available Wprowadzenie: Scleromyxedema jest przewlekłą chorobą zaliczaną domucynoz. Kryteria jej rozpoznania to: charakterystyczne twardzinopodobnezmiany skórne, gammopatia monoklonalna bez współistniejącychzaburzeń funkcji tarczycy, awbadaniu histopatologicznym rozplemfibroblastów i złogi mucyny w przestrzeniach międzykomórkowych. Cel pracy: Przedstawienie dwóch przypadków scleromyxedema o różnymobrazie klinicznym. Opis przypadku: Przedstawiamy dwóch pacjentów chorujących na scleromyxedema:67-letniego, u którego klinicznie dominowały stwardnienia,oraz 53-letniego z przewagą wykwitów o charakterze grudek. U każdegoz chorych stosowano odmienną, indywidualnie dobraną terapię.Pierwszemu podawano początkowo prednizon i chlorambucil, a następniepulsy prednizonu i cyklofosfamidu, drugi był leczony pulsami melfalanu.Stosowane leczenie doprowadziło do stłumienia procesu chorobowego,zwolniło jego postęp, jednak nie spowodowało remisji. Wnioski: Niezależnie od obrazu klinicznego leczenie scleromyxedemanastręcza trudności w związku z ograniczoną skutecznością stosowanychmetod, ich działaniami niepożądanymi lub ograniczoną dostępnością.

  3. Utility-aware screening with clique-oriented prioritization.

    Science.gov (United States)

    Swamidass, S Joshua; Calhoun, Bradley T; Bittker, Joshua A; Bodycombe, Nicole E; Clemons, Paul A

    2012-01-23

    Most methods of deciding which hits from a screen to send for confirmatory testing assume that all confirmed actives are equally valuable and aim only to maximize the number of confirmed hits. In contrast, "utility-aware" methods are informed by models of screeners' preferences and can increase the rate at which the useful information is discovered. Clique-oriented prioritization (COP) extends a recently proposed economic framework and aims--by changing which hits are sent for confirmatory testing--to maximize the number of scaffolds with at least two confirmed active examples. In both retrospective and prospective experiments, COP enables accurate predictions of the number of clique discoveries in a batch of confirmatory experiments and improves the rate of clique discovery by more than 3-fold. In contrast, other similarity-based methods like ontology-based pattern identification (OPI) and local hit-rate analysis (LHR) reduce the rate of scaffold discovery by about half. The utility-aware algorithm used to implement COP is general enough to implement several other important models of screener preferences.

  4. The Influence of Fabrication Conditions on the Physical Properties of PLZT:Nd3+ Ceramics

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    Płonska M.

    2013-12-01

    Full Text Available Celem niniejszej pracy było zbadanie wpływu warunków wytwarzania i zastosowanej domieszki neodymu na właściwości fizyczne ceramiki (Pbo.98Lao.o2(Zro.65Tio.35o.9s03, określanej mianem PLZT:Nd3+. Wszystkie proszki przygotowanych składów syntetyzowano metodą konwencjonalną, z tlenków o wysokiej czystości (>99.9%. Próbki ceramiczne zagęszczano techniką swobodnego spiekania i jednoosiowego prasowania na gorąco. Wykonane badania dały szczegółowy opis zależności między stosowaną domieszką oraz przyjętymi warunkami wytwarzania oraz wpływu na dielektryczne i optyczne właściwości otrzyma- nych materiałów ceramicznych. Optymalne warunki przygotowania PLZT:Nd3+, jak również zastosowane stężenia aktywatora Nd3+ zostały określone w odniesieniu do potencjalnych zastosowań optoelektronicznych.

  5. In vivo reconstitution of algal triacylglycerol production in Saccharomyces cerevisiae

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    Chun-Hsien eHung

    2016-02-01

    Full Text Available The current fascination with algal biofuel production stems from a high lipid biosynthetic capacity and little conflict with land plant cultivation. However, the mechanisms which enable algae to accumulate massive oil remain elusive. An enzyme for triacylglycerol (TAG biosynthesis in Chlamydomonas reinhardtii, CrDGTT2, can produce a large amount of TAG when expressed in yeast or higher plants, suggesting a unique ability of CrDGTT2 to enhance oil production in a heterologous system. Here, we performed metabolic engineering in Saccharomyces cerevisiae by taking advantage of CrDGTT2. We suppressed membrane phospholipid biosynthesis at the log phase by mutating OPI3, enhanced TAG biosynthetic pathway at the stationary phase by overexpressing PAH1 and CrDGTT2, and suppressed TAG hydrolysis on growth resumption from the stationary phase by knocking out DGK1. The resulting engineered yeast cells accumulated about 70-fold of TAG compared with wild type cells. Moreover, TAG production was sustainable. Our results demonstrated the enhanced and sustainable TAG production in the yeast synthetic platform.

  6. Intoxicación por drogas

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    I. Gainza

    Full Text Available El consumo de drogas ilegales en nuestro país ha experimentado un notable cambio en los últimos años, relegando a la heroína e incorporando la cocaína, los derivados anfetamínicos como el "éxtasis" (MDMA, el "éxtasis líquido" (GHB y, en menor medida, la ketamina. Se lleva a cabo una revisión de la intoxicación aguda por opiáceos y de su tratamiento en los servicios de urgencias, teniendo en cuenta el descenso progresivo de los casos que se presentan con el advenimiento de nuevas formas de administración, así como la presencia de nuevas drogas adictivas que han dado lugar a un desplazamiento en los hábitos de consumo. Se expone la intoxicación por cocaína haciendo referencia a la clínica, el diagnóstico y el tratamiento. Se realiza una revisión sobre el cannabis y sus derivados, la historia de su consumo y preparaciones utilizadas, los efectos que producen en los distintos sistemas del organismo y sus principales mecanismos de acción. Por último se comentan los efectos del LSD y de las setas alucinógenas.

  7. BADANIE EWOLUCJI STANU TECHNICZNEGO BUDYNKU

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    Beata NOWOGOŃSKA

    2016-07-01

    Full Text Available Perspektywa utrzymania budynków mieszkalnych w odpowiednim stanie technicznym narzuca zadania optymalnego planowania prac remontowych, a prawidłowe opracowanie zakresu i programu remontu wymaga ustalenia diagnozy. Diagnostyka stanowi podstawę właściwie prowadzonej działalności remontowej w każdym obiekcie technicznym. Diagnoza obejmuje zadania dotyczące zarówno oceny aktualnego stanu technicznego jak i prognozy rozwoju zmian tego stanu. Prognostyczny opis czasu życia budynku w ujęciu matematycznym pozwala na opracowanie precyzyjnych strategii przywracających odpowiedni poziom efektywności eksploatacyjnych. Opracowany model predykcji właściwości użytkowych budynku pozwala na przewidywanie zmian stanu technicznego budynku. W artykule przedstawiona jest problematyka badania ewolucji stanu technicznego wykonanego w technologii tradycyjnej. Budynek i jego elementy składowe w każdej chwili użytkowania znajdują się w pewnym stanie technicznym, a zmiany stanu technicznego traktuje się jako ciąg stanów uporządkowanych według wartości zmiennej czasowej. W artykule zaprezentowana jest także ocena zgodności zaproponowanego modelu z wynikami kontroli okresowych budynków w Żarach.

  8. Opinion - Thyroid (dysfunction in heart failure: is it a potential target for medical treatment?

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    Alessandro Pingitore

    2005-07-01

    Full Text Available Alessandro Pingitore, Giorgio IervasiInstitute of Clinical Physiology, CNR, Pisa, ItalyIntroductionCurrently, there is little doubt that activation of the neuroendocrine (NE system is predominately responsible for the progressive decline of heart function in heart failure (HF. This is due to the complex action of neurotransmitters, hormonal factors, and/or immunological pathways. Evidence that supports this point of view is the clear prognostic benefit and the reduction of HF progression by using NE-guided therapeutic approaches (SOLVD investigators 1992; Eichhorn and Bristow 1996; Packer et al 1996; Opie 2004; Solomon et al 2004. However, the fact that HF represents one of the major causes of morbidity and mortality in Western countries also suggests that the current portfolio of NE antagonists fails to completely explain and possibly counteract disease progression (Guyatt and Deveraux 2004. In this context, interest in the relationship between thyroid hormones (THs and HF is increasingly gaining prominence. The chief reason for the latter is the emerging novel actions of THs on the cardiovascular system and, more specifically, the role of TH as a prognostic biomarker of cardiac disease as well as the potential benefit of TH administration in patients with HF.

  9. A DANÇA E O XAMANISMO: OS PROCESSOS EDUCATIVOS MITO-RITUALÍSTICO DO COTIDIANO GUARANI

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    ANA LUISA TEIXEIRA DE MENEZES

    2008-06-01

    Full Text Available ABSTRACT: This article aims at developing a reflection over the Guarani dance and shamanism, highlighting the mythological and ritualistic aspects within an ordinary and educative process. In the dance, a conscious of collectivity is experienced through thought andfeeling. The experience provoked by the collectivity in the dance can be translated as nhaderetê, body of all, divine and joy producer. In the daily bleakness, the Guarani produce beauty and joy, because these are the expression of their divine entities. Throughout conversation and testimonies of young Guarani, we sought to highlight their elaborations of the mythological knowledge and daily living. The rite has a living function of the myth and these two aspects areperceived as interweaved to the dance and to the Opy. All these aspects are lived by the young and adults in a very disturbing way that leads them to a permanent movement of questioning, search and redefinition. In this process, the Opy, the Karai and the dance are highlighted as basis of the Guarani culture and serv as stabilization points within a very dynamic daily. The dance, as rite, transports the Guarani to a time when they acknowledge their identities, in a life rhythm. The Guarani rite is linked to a deep structure of the emotional collective organization, in a vital function, of spiritual elevation and integration to their belonging system. To the Guarani, Nhanderú taught the dance and enforced them to dance. This becomes from a mythological perception and its appearance is confounded with the own Guarani existence. Thespirituality appears from a vital relation of movement. The shamanistic education is learned by the senses. The main knowledge notion is the Arandurekó, knowledge that is learned throughoutlife, in proper time and rhythm. The dance-rhythm enables the connection between body and spirit, proportioning a sensible hearing of gestures, diseases, and behavior as reflexive learningspaces. By putting

  10. Radosław Kaleta, Białorusko-polska homonimia międzyjęzykowa, Warszawa: Slawistyczny Ośrodek Wydawniczy, 2014, 167 ss.

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    Maksim Duszkin

    2015-12-01

    Full Text Available Review The text is a presentation of R. Kaleta's book Białorusko-polska homonimia międzyjęzykowa published in 2014 by the Slavic Publishing Centre of the Institute of Slavic Studies PAS. The monograph includes an analysis of source literature and some theoretical reflections on a phenomenon of the so-called interlanguage homonymy. The book also includes a brief vocabulary of selected Belarusian-Polish interlanguage homonyms.   Recenzja W recenzji przedstawiono wydaną w 2014 r. w Slawistycznym Ośrodku Wydawniczym Instytutu Slawistyki PAN książkę R. Kalety Białorusko-polska homonimia międzyjęzykowa. Monografia zawiera między innymi opis literatury przedmiotu oraz rozważania teoretyczne, dotyczące zjawiska tzw. hominimii międzyjęzykowej. Znaleźć w niej można również słowniczek wybranych białorusko-polskich hominimów międzyjęzykowych.

  11. Acceptance Test Data for BWXT Coated Particle Batch 93164A Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    Coated particle fuel batch J52O-16-93164 was produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), or may be used as demonstration production-scale coated particle fuel for other experiments. The tristructural-isotropic (TRISO) coatings were deposited in a 150-mm-diameter production-scale fluidizedbed chemical vapor deposition (CVD) furnace onto 425-μm-nominal-diameter spherical kernels from BWXT lot J52L-16-69316. Each kernel contained a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO) and was coated with four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batch was sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batch was designated by appending the letter A to the end of the batch number (i.e., 93164A).

  12. The Effectiveness of Emotion Regulation Training and Cognitive Therapy on the Emotional and Addictional Problems of Substance Abusers

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    Mahmoud Golzari

    2010-06-01

    Full Text Available "n Objectives: The purpose of this study was to investigate the effectiveness of emotional regulation training group therapy, based on Dialectical Behavioral Therapy(DBT and Cognitive Therapy, on improving emotional regulation and distress tolerance skills and relapse prevention in addicts . "nMethod: In a quasiexperimental study, 39 patients with the diagnosis of opioid dependence based on DSM-IV criteria were randomly assigned in to two experimental and one control groups. The experimental groups took 10 ninety-minute sessions of group therapy. The subjects were evaluated using the Opiate Treatment Index (OPI, General Health Questionnaire-28 (GHQ-28, and Distress Tolerance and Difficulties in Emotion Regulation Scales prior to the start of treatment, and at the sixteenth session. The control group did not take group therapy and was merely treated with naltrexone. Data were analyzed using repeated measures ANOVA and ÷ 2 test . Results: Scheffe test showed that both emotion regulation training and cognitive therapy were more effective than naltrexone increasing distress tolerance, emotion regulation enhancement, and decreasing the amount of drug abuse, health improvement, social functioning, somatic symptoms, anxiety, social dysfunction and depression enhancement(P<0.05. In addition, emotion regulation training was more effective than cognitive therapy, increasing distress tolerance and emotional regulation enhancement (p<0.05. Conclusion: It seems that DBT skill training increase the effectiveness of pharmacotherapy and is more effective than cognitive therapy.

  13. Green-Ampt approximations: A comprehensive analysis

    Science.gov (United States)

    Ali, Shakir; Islam, Adlul; Mishra, P. K.; Sikka, Alok K.

    2016-04-01

    Green-Ampt (GA) model and its modifications are widely used for simulating infiltration process. Several explicit approximate solutions to the implicit GA model have been developed with varying degree of accuracy. In this study, performance of nine explicit approximations to the GA model is compared with the implicit GA model using the published data for broad range of soil classes and infiltration time. The explicit GA models considered are Li et al. (1976) (LI), Stone et al. (1994) (ST), Salvucci and Entekhabi (1994) (SE), Parlange et al. (2002) (PA), Barry et al. (2005) (BA), Swamee et al. (2012) (SW), Ali et al. (2013) (AL), Almedeij and Esen (2014) (AE), and Vatankhah (2015) (VA). Six statistical indicators (e.g., percent relative error, maximum absolute percent relative error, average absolute percent relative errors, percent bias, index of agreement, and Nash-Sutcliffe efficiency) and relative computer computation time are used for assessing the model performance. Models are ranked based on the overall performance index (OPI). The BA model is found to be the most accurate followed by the PA and VA models for variety of soil classes and infiltration periods. The AE, SW, SE, and LI model also performed comparatively better. Based on the overall performance index, the explicit models are ranked as BA > PA > VA > LI > AE > SE > SW > ST > AL. Results of this study will be helpful in selection of accurate and simple explicit approximate GA models for solving variety of hydrological problems.

  14. Characteristics of terrestrial basaltic rock populations: Implications for Mars lander and rover science and safety

    Science.gov (United States)

    Craddock, Robert A.; Golombek, Matthew P.

    2016-08-01

    We analyzed the morphometry of basaltic rock populations that have been emplaced or affected by a variety of geologic processes, including explosive volcanic eruptions (as a proxy for impact cratering), catastrophic flooding, frost shattering, salt weathering, alluvial deposition, and chemical weathering. Morphometric indices for these rock populations were compared to an unmodified population of rocks that had broken off a solidified lava flow to understand how different geologic processes change rock shape. We found that a majority of rocks have an sphericity described as either a disc or sphere in the Zingg classification system and posit that this is a function of cooling fractures in the basalt (Zingg [1935] Schweiz. Miner. Petrogr. Mitt., 15, 39-140). Angularity (roundness) is the most diagnostic morphometric index, but the Corey Shape Factor (CSF), Oblate-Prolate Index (OPI) and deviation from compactness (D) also sometimes distinguished weathering processes. Comparison of our results to prior analyses of rock populations found at the Mars Pathfinder, Spirit, and Curiosity landing sites support previous conclusions. The observation that the size-frequency distribution of terrestrial rock populations follow exponential functions similar to lander and orbital measurements of rocks on Mars, which is expected from fracture and fragmentation theory, indicates that these distributions are being dominantly controlled by the initial fracture and fragmentation of the basalt.

  15. Problemy diagnostyczne na podstawie obserwowanego przypadku chorej z nużliwością mięśni prążkowanych, współwystępowaniem zespołu toczniopodobnego i rozpoznaną boreliozą

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    Antoni Hrycek

    2010-10-01

    Full Text Available Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU.Nużliwość mięśni prążkowanych jest chorobą, której współistnieniez TRU nie jest zbyt częste, lecz sporadycznie pojawiały się jużopisy takich przypadków.W niniejszej pracy przedstawiono opis chorej z rozpoznaną nużliwościąmięśni prążkowanych, u której wykonano tymektomię i pokilkunastu latach od tego momentu rozpoznano zespół toczniopodobny.Dołączenie się boreliozy jeszcze bardziej skomplikowałoobraz kliniczny choroby. W pracy przedstawiono trudności diagnostyczne,jakie wystąpiły w obserwowanym przypadku.

  16. The Electronic Historical Latvian Dictionary Based on the Corpus of Early Written Latvian Texts

    Directory of Open Access Journals (Sweden)

    Everita Andronova

    2016-12-01

    Główny nacisk położono na opis haseł słownikowych, zawierający istotne uwagi praktyczne i teoretyczne. Omówiono poszczególne części hasła słownikowego, po czym umieszczono komentarz odnoszący się do różnych kwestii związanych z daną częścią (np. wybór hasła wyrazowego i przedstawienia wersji pisowni i do przyję­tych rozwiązań. Szczególną uwagę poświęcono główce hasła, objaśnieniu znaczenia wynikającego z przykładów występujacych w korpusie, różnym rodzajom kolokacji i ich przedstawieniu w słowniku, jak też informacjom etymologicznym. Na końcu zamieszczono zwięzły przegląd oprogramowania słownikowego TLex 2013, oparty na doświadczeniu autorów, zdobytym podczas pracy z tym narzędziem.

  17. Current perspectives of acute pain treatment Perspectivas actuales de tratamiento del paciente con dolor agudo

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    Tiberio Alvarez Echeverri

    1993-03-01

    Full Text Available

    In the last years opioids have become of great importance in the relief of postoperative and other forms of acute pain. Reasons for this trend have been the availability of agonist opioids like phentanyl. sulphentanyl and alphentanyl and the results of research on the physlology. The pharmacology and the chemistry of drug receptors and neurotransmitters. The studies on chemicals other than opioids that contribute to pain relief when administered through different ways. specially the spinal. Have also influenced such a trend.

    En los últimos años los opiáceos han adquirido gran importancia en el alivio del dolor agudo especialmente del tipo postoperatorio. Una de las razones ha sido la disponibilidad de morfínicos agonistas como el fentanil, el sufentanil y el alfentanil; otra es la investigación de la fisiología, la farmacología y la química de los receptores y los neurotransmisores como de sustancias diferentes a los opláceos, aplicadas por diferentes vías en especial la espinal, que coadyuvan al alivio del dolor.

  18. Salvia divinorum Epling & Játiva (Maria Pastora e Salvinorina A: crescente uso recreacional e potencial de abuso Salvia divinorum Epling & Játiva ("ska María Pastora" and Salvinorin A: increasing recreational use and abuse potential

    Directory of Open Access Journals (Sweden)

    R.J. Schneider

    2010-09-01

    Full Text Available A planta Salvia divinorum Epling & Játiva (SDI, da família Lamiaceae, tem sido usada por séculos pela cultura mazateca e vem ganhando popularidade como droga recreacional nos últimos anos. Seu princípio ativo - Salvinorina A (SA - é agonista dos receptores opióides kappa, com potencial psicotrópico. A utilização da planta vem crescendo na Europa e na América do Norte, apesar de ainda não existirem provas concretas sobre abuso. A presente revisão da literatura contemporânea aborda as evidências sobre o potencial de abuso de SDI, bem como o crescente uso recreacional, ainda que seja alucinógeno permitido legalmente e de fácil compra em muitos países.The plant Salvia divinorum Epling & Játiva (SDI, of the Lamiaceae family, has been used for centuries by the Mazateca culture and has gained popularity as a recreational drug in the last years. Its active principle, Salvinorin A (SA, is a potentially psychotropic agonist of the kappa opioid receptors. The use of SDI has increased in Europe and North America, although there are no concrete proofs about abuse. The present review discusses current evidence on potential SDI abuse, as well as its increasing recreational use, although it is considered a legalized hallucinogen easily acquired in many countries.

  19. Formação do acadêmico de enfermagem e seu contato com as drogas psicoativas

    Directory of Open Access Journals (Sweden)

    Violante Augusta Braga Batista

    2004-01-01

    Full Text Available Objetivamos aprender junto al estudiante de enfermería de la UFC el conocimiento que tiene sobre las drogas psicoactivas y su percepción en cuanto a su uso. Investigación descriptiva, dentro de un abordaje cuanti-cualitativo, realizada con 38 estudiantes de enfermería del 4º y el 8º semestres del 2002. Utilizamos un cuestionario autoaplicable con preguntas abiertas y cerradas. Constatamos que las sustancias mas utilizadas fueron el alcohol y los inhaladores; nunca usaron macoña, crack, cocaína, anfetaminas y opiáceos; desaprueban el uso de cocaina, crack e inhalantes; refieren tener algún tipo de información o conocimiento sobre la dependencia química adquiridos a través de los medios de comunicación o universidad. Con el estudio nos aproximamos, un poco mas, al universo del estudiante de enfermería y su relación con la dependencia química.

  20. Metabolism of hydrophobic carbon sources and regulation of it in n-alkane-assimilating yeast Yarrowia lipolytica.

    Science.gov (United States)

    Fukuda, Ryouichi

    2013-01-01

    A potent ability to assimilate hydrophobic compounds, including n-alkanes and fatty acids as carbon sources, is one of important characteristics of the yeast Yarrowia lipolytica, and has been studied for both basic microbiological interest and biotechnological applications. This review summarizes recent progress on the metabolism of n-alkanes and its transcriptional control in response to n-alkanes and to fatty acids in Y. lipolytica. In the metabolism of n-alkanes, cytochromes P450ALK catalyze their initial hydroxylation to fatty alcohols, which are subsequently converted to fatty acids and utilized. The transcription of ALK1, encoding a predominant cytochrome P450ALK, is regulated in response to n-alkanes by two basic helix-loop-helix transcription activators, Yas1p and Yas2p, and Opi1-family transcription repressor Yas3p. Transcription of the genes involved in fatty acid utilization and peroxisome biogenesis is controlled by Ctf1-family Zn2Cys6 type transcription factor Por1p in response to fatty acids in Y. lipolytica.

  1. 方寸炫彩 秀色从指尖开始

    Institute of Scientific and Technical Information of China (English)

    甄丽娜

    2013-01-01

    <正>转眼间已是初冬季节,专柜内新款的冬装、彩妆早已粉墨登场,美女们开始辗转于各柜台挑选,为自己的魅力形象做储备。都说北方冬季的到来,女人将是城市一道靓丽的风景线;漂亮的指甲造型、优雅得体的衣着妆容相得益彰,让这个萧瑟的冬季变得闪亮。国际大牌的色彩诱惑甲油品牌繁多,纵观整个甲油市场,美国OPI和CND两个国际美甲品牌因其自身优质的产品质量,丰富的色彩而受到众多女性消费者的喜爱。OPI,成立于二十世纪七十年代,是国际顶级时尚杂志中"出镜率"最高的专业美甲品牌;其产品涉及手、足保养护理系列,全身保养系列、指

  2. [Effect of transcutaneous acupoint electric stimulation on perioperative intravenous anesthesia in patients of transsphenoidal pituitary tumor resection].

    Science.gov (United States)

    Chen, Xue; Wang, Bao-Guo; Li, Jin; An, Li-Xin

    2013-08-01

    To observe the impacts of transcutaneous acupoint electric stimulation on hemodynamics, anesthetic and relevant complications in patients of transsphenoidal pituitary tumor resection (TPTR). Ninety cases of the selective TPTR were randomized into a transcutaneous acupoint electric stimulation group (group T), a sham-acupoint group (group S) and a control group (group C); 30 cases in each one. In group T, the transcutaneous acupoint electric stimulation at Hegu (LI 4), Waiguan (TE 5), Jinmen (BL 63), Taichong (LR 3), Zusanli (ST 36) and Qiuxu (GB 40). In group S, the transcutaneous acupoint electric stimulation was applied to the sham-acupoints. In group C, the acupoints selected were same as those in group T, but the electrode pads were just attached on the related points with no-electric stimulation. The electric stimulation lasted from analgesic induction till the end of the operation. The endotracheal intubation was done under the induction by propofol, fentanyl and vecuronium bromide. Propofol and remifentanil were maintained till the end of operation. Blood pressure, heart rate, bispectral index (BIS) value, anesthetic and postoperative recovery situation were recorded. The hemodynamics maintained stably in each group. In group T, the mean arterial pressure 1 min after intubation, after extubation and during directional force recovery was all lower than the other two groups respectively (all Pelectric stimulation improves the stability of hemodynamics in perioperative stage, reduces the intraoperative opi oids dosages and improves the quality of anesthetic recovery.

  3. Drugs of abuse detection in saliva based on actuated optical method

    Science.gov (United States)

    Shao, Jie; Li, Zhenyu; Jiang, Hong; Wang, Wenlong; Wu, Yixuan

    2014-12-01

    There has been a considerable increase in the abuse of drugs during the past decade. Combing drug use with driving is very dangerous. More than 11% of drivers in a roadside survey tested positive for drugs, while 18% of drivers killed in accidents tested positive for drugs as reported in USA, 2007. Toward developing a rapid drug screening device, we use saliva as the sample, and combining the traditional immunoassays method with optical magnetic technology. There were several methods for magnetic nanoparticles detection, such as magnetic coils, SQUID, microscopic imaging, and Hall sensors. All of these methods were not suitable for our demands. By developing a novel optical scheme, we demonstrate high-sensitivity detection in saliva. Drugs of abuse are detected at sub-nano gram per milliliter levels in less than 120 seconds. Evanescent wave principle has been applied to sensitively monitor the presence of magnetic nanoparticles on the binding surface. Like the total internal reflection fluorescence microscope (TIRFM), evanescent optical field is generated at the plastic/fluid interface, which decays exponentially and penetrates into the fluid by only a sub-wavelength distance. By disturbance total internal reflection with magnetic nanoparticles, the optical intensity would be influenced. We then detected optical output by imaging the sensor surface onto a CCD camera. We tested four drugs tetrahydrocannabinol (THC), methamphetamine (MAMP), ketamine (KET), morphine (OPI), using this technology. 100 ng mL-1 sensitivity was achieved, and obvious evidence showed that this results could be improved in further researches.

  4. ANALIZA STRUKTURE STAVOVA I MI ŠLJENJA NASTAVNIKA RAZREDNE NASTAVE PREMA FIZIČKOM VASPITANJU

    Directory of Open Access Journals (Sweden)

    Enver Međedović

    2007-05-01

    Full Text Available and ac ti vity in so cial or ga ni za ti ons for physi cal cul tu re, en ga ged pe da go gu es physi cal cul tu res in pe da go gic ac ti vity, analyses and for ti fi ca tion re spon si bi lity in work sport union com mu nity, par ti ci pa tion school on con test in fra me school union for sport and olympic edu ca tion, en ga ge ment on re se arch pro ject, opi nion abo ut or ga ni za tion work physi cal edu ca tion from I to IV gra des pri mary school, sum pos si bi lity for advance ment physi cal edu ca tion thro ugh co o pe ra tion with pe da go gic of fi ce, in fl u en ce school equ ip ment te ac her on qu a lity of work. On pat tern of 60 te ac hers physi cal edu ca tion, pe da go gu es physi cal edu ca tion which work in pri mary and high school on re gion com mu nity No vi Pa zar a way qu e sti on mark are at ta i ned re sults which are il lu stra ting ta bu lar, grap hic, de scrip ti ve met hod.

  5. Acceptance Test Data for Candidate AGR-5/6/7 TRISO Particle Batches BWXT Coater Batches 93165 93172 Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    Coated particle fuel batches J52O-16-93165, 93166, 93168, 93169, 93170, and 93172 were produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). Some of these batches may alternately be used as demonstration coated particle fuel for other experiments. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μmnominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A).

  6. EFFECT OF METHIONINE ENKEPHALIN ON MIGRATION OF MACROPHAGES FROM MICE WITH IMPAIRED LIVER

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective To observe the effects of methionine enkephalin (M-Enk) on migration of macrophages from mice with impaired liver and its immunomodulatory mechanisms. Methods Liver of mice was impaired by feeding CCl4 and macrophage migration inhibitory factor (MMIF) was produced by Con A-stimulated spleen lympho- cytes. Inhibition of macrophage migration was measured in reaction system by adding M-Enk. Results Migration of macrophages in both liver-impaired and control group were suppressed by MMIF, but the suppression might be re- versed by adding 1 μmol/L M-Enk (P<0. 05). M-Enk could significantly inhibit in vitro both of the combination of MMIF with macrophages and production of MMIF from lymphocytes (P<0. 01). Macrophages from liver-imparied group showed a higher sensitivity compared to the control group (P<0. 05). Conclusion The study suggests that opi- oid peptieds play an important role in the modulation of the immune response under stress as liver impairment.

  7. Intoxicación aguda por heroína

    Directory of Open Access Journals (Sweden)

    Guillermo Porras-Morales

    2004-03-01

    Full Text Available La intoxicación por opiáceos se presenta casi siempre como consecuencia de una sobredosis accidental de un derivado de éstos, usualmente la heroína por inyección. Otras formas de intoxicación, a las que no somos ajenos en nuestro medio, son los llamados correos de drogas, "body packers" o mulas, utilizados en el tráfico internacional de transporte de drogas. En estos casos la droga es generalmente tragada, envuelta en condones, que pueden contener heroína o cocaína. Su ruptura puede conducir a toxicidad severa y letal. Los antecedente de un viaje reciente en avión en un paciente con cuadro clínico de intoxicación, pueden justificar la indicación de una radiografía de abdomen como método diagnóstico e incluso la cirugía para limpieza intestinal como parte de su abordaje terapéutico.

  8. [Topsoil phosphorus forms and availability of different soil and water conservation plantations in typical black soil region, northeast China].

    Science.gov (United States)

    Yang, Xiao-Yan; Fan, Rui-Ying; Wang, En-Heng; Xia, Xiang-You; Chen, Xiang-Wei

    2014-06-01

    Aiming to understand soil phosphorus status of plantations in typical black soil region of Northeast China, the topsoil (0-10 cm) phosphorus fractionations and its availability were examined in four soil and water conservation plantations dominantly composed of Larix gmelini, Fraxinus mandshurica, Pinus sylvestris var. mongolica and Populus nigra var. italica x P. cathayan, respectively. The results showed that total P, Olsen-P and the concentration of different P fractionations in F. mandshurica and P. nigra var. italica x P. cathayan plantations were significantly higher than that of the other two coniferous plantations. Organic P was the major fractionation in the four plantations' topsoil, and sodium hydroxide extractable organic P (NaOH-Po ) representing moderately labile organic phosphorus was predominant, which accounted for 58.9% of total P. The contents of H2O-Pi and NaHCO3-P which were more labile to plant were lower, only accounting for 1.2% and 6.6% of total P, respectively. Except for NaHCO3-Po, all the other P fractions of four plantations correlated with each other, and they also had significant correlations with soil organic matter, total P, Olsen-P. Compared with the coniferous plantations, the broadleaf plantations presented higher availability of phosphorus.

  9. Phosphatidate phosphatase regulates membrane phospholipid synthesis via phosphatidylserine synthase.

    Science.gov (United States)

    Carman, George M; Han, Gil-Soo

    2017-08-16

    The yeast Saccharomyces cerevisiae serves as a model eukaryote to elucidate the regulation of lipid metabolism. In exponentially growing yeast, a diverse set of membrane lipids are synthesized from the precursor phosphatidate via the liponucleotide intermediate CDP-diacylglycerol. As cells exhaust nutrients and progress into the stationary phase, phosphatidate is channeled via diacylglycerol to the synthesis of triacylglycerol. The CHO1-encoded phosphatidylserine synthase, which catalyzes the committed step in membrane phospholipid synthesis via CDP-diacylglycerol, and the PAH1-encoded phosphatidate phosphatase, which catalyzes the committed step in triacylglycerol synthesis are regulated throughout cell growth by genetic and biochemical mechanisms to control the balanced synthesis of membrane phospholipids and triacylglycerol. The loss of phosphatidate phosphatase activity (e.g., pah1Δ mutation) increases the level of phosphatidate and its conversion to membrane phospholipids by inducing Cho1 expression and phosphatidylserine synthase activity. The regulation of the CHO1 expression is mediated through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Consequently, phosphatidate phosphatase activity regulates phospholipid synthesis through the transcriptional regulation of the phosphatidylserine synthase enzyme. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc.

    Science.gov (United States)

    Iwanyshyn, Wendy M; Han, Gil-Soo; Carman, George M

    2004-05-21

    Zinc is an essential nutrient required for the growth and metabolism of eukaryotic cells. In this work, we examined the effects of zinc depletion on the regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae. Zinc depletion resulted in a decrease in the activity levels of the CDP-diacylglycerol pathway enzymes phosphatidylserine synthase, phosphatidylserine decarboxylase, phosphatidylethanolamine methyltransferase, and phospholipid methyltransferase. In contrast, the activity of phosphatidylinositol synthase was elevated in response to zinc depletion. The level of Aut7p, a marker for the induction of autophagy, was also elevated in zinc-depleted cells. For the CHO1-encoded phosphatidylserine synthase, the reduction in activity in response to zinc depletion was controlled at the level of transcription. This regulation was mediated through the UAS(INO) element and by the transcription factors Ino2p, Ino4p, and Opi1p that are responsible for the inositol-mediated regulation of UAS(INO)-containing genes involved in phospholipid synthesis. Analysis of the cellular composition of the major membrane phospholipids showed that zinc depletion resulted in a 66% decrease in phosphatidylethanolamine and a 29% increase in phosphatidylinositol. A zrt1Delta zrt2Delta mutant (defective in the plasma membrane zinc transporters Zrt1p and Zrt2p) grown in the presence of zinc exhibited a phospholipid composition similar to that of wild type cells depleted for zinc. These results indicated that a decrease in the cytoplasmic levels of zinc was responsible for the alterations in phospholipid composition.

  11. Information draft on the development of air standards for isopropyl benzene

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    Isopropyl benzene, also commonly referred to as cumene, is a colourless liquid with a sharp, penetrating odour. It is derived from the distillation of coal tar, naphtha and petroleum. It is used mainly as an intermediate in the production of phenol, acetone, and alpha-methyl styrene, all of which are components in plastic resins. Isopropyl benzene is also used as a solvent and thinner for paints and enamels and as an octane booster in aviation gasoline. In 1996, reported atmospheric releases in Canada amounted to 16.4 tonnes, of which 9.1 tonnes were from Ontario sources. Isopropyl benzene is not a significant threat to health in low concentrations. Inhalation exposure can cause dizziness, light-headedness and fainting. Contact with isopropyl benzene can irritate the skin, eyes, nose and mouth. The current Ontario half-hour interim Point of Impingement (OPI) standard and the one-hour Ambient Air Quality Criterion (AAQC) are both set at 100 microgram/cubic meter on the basis of the odour nuisance property of the substance. A review of applicable literature from world-wide sources (and summarized in this report) reveal that four US agencies have developed air quality criteria for isopropyl benzene based on the health effects of the compound. These criteria range from 9 to 585 micrograms/cubic meter for an annual average basis and from 87 to 400 microgram/cubic meter on a 24-hour basis. 40 refs., 1 tab., appendix.

  12. Terpenóides com atividade sobre o Sistema Nervoso Central (SNC Terpenoids with activity in the Central Nervous System (CNS

    Directory of Open Access Journals (Sweden)

    Carolina S. Passos

    2009-03-01

    Full Text Available Os terpenóides constituem um vasto grupo de metabólitos secundários com ações sobre o SNC, destacando-se suas atividades sedativa, ansiolítica, antinociceptiva, anticonvulsivante, pró-convulsivante e alucinógena. Neste trabalho foi realizada uma revisão bibliográfica sobre terpenóides com ações descritas no SNC, enfocando moléculas e sistemas neurotransmissores relacionados com sua atividade. As substâncias abordadas encontram-se divididas em mono, sesqui, di, tri e meroterpenóides e incluem compostos isolados e plantas que apresentam ação principalmente sobre os sistemas neurotransmissores GABAérgico, glutamatérgico, dopaminérgico e opióide.The terpenoids are a large group of secondary metabolites which display many activities in the CNS, such as sedative, ansiolytic, antinociceptive, anticonvulsant, pro-convulsant and hallucinogenic. In this work we performed a research on terpenoids that exert effects on the CNS, focusing molecules and neurotransmitter systems related to their actions. The substances approached were classified as mono, sesqui, di, tri and meroterpenoids and include isolated compounds and plants which exert activities mainly on GABAergic, glutamatergic, dopaminergic and opioid neurotransmitter systems.

  13. Determination of trace mercury in water based on N-octylpyridinium ionic liquids preconcentration and stripping voltammetry.

    Science.gov (United States)

    Li, Zhenhan; Xia, Shanhong; Wang, Jinfen; Bian, Chao; Tong, Jianhua

    2016-01-15

    A novel method for determination of trace mercury in water is developed. The method is performed by extracting mercury firstly with ionic liquids (ILs) and then detecting the concentration of mercury in organic media with anodic stripping voltammetry. Liquid-liquid extraction of mercury(II) ions by four ionic liquids with N-octylpyridinium cations ([OPy](+)) was studied. N-octylpyridinium tetrafluoroborate and N-octylpyridinium trifluoromethylsulfonate were found to be efficient and selective extractant for mercury. Temperature controlled dispersive liquid phase microextraction (TC-DLPME) technique was utilized to improve the performance of preconcentration. After extraction, precipitated IL was diluted by acetonitrile buffer and mercury was detected by differential pulse stripping voltammetry (DPSV) with gold disc electrode. Mercury was enriched by 17 times while interfering ions were reduced by two orders of magnitude in the organic media under optimum condition. Sensitivity and selectivity for electrochemical determination of mercury were improved by using the proposed method. Tap, pond and waste water samples were analyzed with recoveries ranging from 81% to 107% and detection limit of 0.05 μg/L.

  14. Search for dinucleon decay into pions at Super-Kamiokande

    CERN Document Server

    Gustafson, J; Haga, Y; Hayato, Y; Ikeda, M; Iyogi, K; Kameda, J; Kishimoto, Y; Miura, M; Moriyama, S; Nakahata, M; Nakajima, T; Nakano, Y; Nakayama, S; Orii, A; Sekiya, H; Shiozawa, M; Takeda, A; Tanaka, H; Tomura, T; Wendell, R A; Irvine, T; Kajita, T; Kametani, I; Kaneyuki, K; Nishimura, Y; Richard, E; Okumura, K; Labarga, L; Fernandez, P; Berkman, S; Tanaka, H A; Tobayama, S; Kearns, E; Raaf, J L; Stone, J L; Sulak, L R; Goldhaber, M; Carminati, G; Kropp, W R; Mine, S; Weatherly, P; Renshaw, A; Smy, M B; Sobel, H W; Takhistov, V; Ganezer, K S; Hartfiel, B L; Hill, J; Hong, N; Kim, J Y; Lim, I T; Akiri, T; Himmel, A; Scholberg, K; Walter, C W; Wongjirad, T; Ishizuka, T; Tasaka, S; Jang, J S; Learned, J G; Matsuno, S; Smith, S N; Hasegawa, T; Ishida, T; Ishii, T; Kobayashi, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Suzuki, T TsukamotoA T; Takeuchi, Y; Yano, T; Hirota, S; Huang, K; Ieki, K; Kikawa, T; Minamino, A; Nakaya, T; Suzuki, K; Takahashi, S; Fukuda, Y; Choi, K; Itow, Y; Mitsuka, G; Suzuki, T; Mijakowski, P; Hignight, J; Imber, J; Jung, C K; Palomino, J L; Yanagisawa, C; Ishino, H; Kayano, T; Kibayashi, A; Koshio, Y; Mori, T; Sakuda, M; Kuno, Y; Tacik, R; Kim, S B; Okazawa, H; Choi, Y; Nishijima, K; Koshiba, M; Suda, Y; Totsuka, Y; Yokoyama, M; Bronner, C; Martens, K; Marti, Ll; Suzuki, Y; Vagins, M R; Martin, J F; de Perio, P; Konaka, A; Wilking, M J; Chen, S; Zhang, Y; Wilkes, R J

    2015-01-01

    A search for dinucleon decay into pions with the Super-Kamiokande detector has been performed with an exposure of 282.1 kiloton-years. Dinucleon decay is a process that violates baryon number by two units. We present the first search for dinucleon decay to pions in a large water Cherenkov detector. The modes $^{16}$O$(pp) \\rightarrow$ $^{14}$C$\\pi^{+}\\pi^{+}$, $^{16}$O$(pn) \\rightarrow$ $^{14}$N$\\pi^{+}\\pi^{0}$, and $^{16}$O$(nn) \\rightarrow$ $^{14}$O$\\pi^{0}\\pi^{0}$ are investigated. No significant excess in the Super-Kamiokande data has been found, so a lower limit on the lifetime of the process per oxygen nucleus is determined. These limits are: $\\tau_{pp\\rightarrow\\pi^{+}\\pi^{+}} > 7.22 \\times 10^{31}$ years, $\\tau_{pn\\rightarrow\\pi^{+}\\pi^{0}} > 1.70 \\times 10^{32}$ years, and $\\tau_{nn\\rightarrow\\pi^{0}\\pi^{0}} > 4.04 \\times 10^{32}$ years. The lower limits on each mode are about two orders of magnitude better than previous limits from searches for dinucleon decay in iron.

  15. Automatic Addition of Genre Information in a Japanese Dictionary

    Directory of Open Access Journals (Sweden)

    BLIN, Raoul

    2012-10-01

    Full Text Available This article presents the method used for the automatic addition of genre information to the Japanese entries in a Japanese-French dictionary. The dictionary is intended for a wide audience, ranging from learners of Japanese as a second language to researchers. The genre characterization is based on the statistical analysis of corpora representing different genres. We will discuss the selection of genres and corpora, the tool and method of analysis, the difficulties encountered during this analysis and their solutions.-----Članek predstavlja metodo za samodejno dodajanje informacij o žanru k japonskim iztočnicam v japonsko-francoskem slovarju, ki je namenjen tako učencem japonščine kot tujega jezika kot tudi raziskovalcem. Žanrski opis je osnovan na statistični analizi korpusov različnih žanrov. Članek opisuje izbiro žanrov in korpusov, orodja in metode za analizo, težave pri analizi in rešitve zanje.

  16. Fentanilo en el dolor irruptivo oncológico

    Directory of Open Access Journals (Sweden)

    J. Moya Riera

    2013-06-01

    Full Text Available El control del dolor en el paciente oncológico es un aspecto importante en la calidad de la asistencia a las personas. El fármaco de elección en el tratamiento del DIO requiere una potencia adecuada y una muy rápida velocidad de absorción. Esta velocidad es un aspecto crítico. Las preparaciones de fentanilo, debido a su gran potencia, son probablemente los fármacos que el clínico debe emplear en el DIO, pero no todas las preparaciones de fentanilo presentan una cinética similar. Las propiedades farmacocinéticas del comprimido bucal de fentanilo (CBF con tecnología OraVescent®, han mostrado una gran velocidad de absorción, mucho más rápida que otras preparaciones de opiáceos. Se dispone de evidencia suficiente que indica que la preparación de CBF es eficaz en los episodios de DIO. El CBF ha mostrado eficacia también en dolor irruptivo no relacionado con el cáncer.

  17. Międzynarodowy Standard Sprawozdawczości Finansowej dla Małych i Średnich Przedsiębiorstw - istota, ocena, przyszłość

    Directory of Open Access Journals (Sweden)

    Marcin Kędzior

    2010-11-01

    Full Text Available Celem artykułu jest przedstawienie istoty oraz ocena oraz określenie przyszłości Międzynarodowego Standardu Sprawozdawczości Finansowej dla Małych i Średnich Przedsiębiorstw. W opracowaniu zaprezentowano definicję sektora małych i średnich przedsiębiorstw, cele i potrzeby wprowadzenia standardu. W dalszej części przeprowadzono opis standardów, dokonano jego oceny, a także przedstawiono opinie przedstawicieli wybranych organizacji księgowych i audytorskich w Europie. Poddano analizie wpływ MSSF dla MŚP na sektor MŚP oraz badania dotyczące MSSF dla MŚP. Zaprezentowano krajowe systemy rachunkowości po wprowadzeniu tych standardów, a także zarysowano ich przyszłość na świecie i dokonano oceny całego projektu.

  18. OUTRAS ALEGRIAS: CACHAÇA E CAUIM NA EMBRIAGUEZ MBYÁ-GUARANI

    Directory of Open Access Journals (Sweden)

    Guilherme Orlandini Heurich

    2015-12-01

    Full Text Available Resumo A partir de trabalho de campo realizado entre os Mbyá-guarani, este artigo procura compreender os sentidos que toma a embriaguez proporcionada pelo consumo de cachaça, focando na descrição dos Mbyá sobre a alteração e os "bailes", bem como na relação entre a cachaça e os espectros ãgue. Lanço mão da expressão "outras alegrias" que descreve a alegria proporcionada pelos bailes e pela embriaguez, principalmente em oposição à alegria experienciada na "casa cerimonial" (opy. Mostro, por outro lado, que as "outras alegrias" precisam ser pensadas também como "alegrias-Outras", pois quando a embriaguez se torna raiva contra os próprios parentes, os mortos aparecem como o sujeito primordial dessa alteração que a cachaça proporciona. Por fim, associo a embriaguez de cachaça a etnografias sobre cauinagens de outros povos ameríndios, sugerindo aproximações e diferenças com esses contextos. Para os Mbyá, a embriaguez é uma forma de alegria e também de alteração, na qual a pessoa se aproxima dos espíritos dos mortos e pode, no limite, tomar os seus parentes por contrários.

  19. The dynamics of LTR retrotransposon accumulation across 25 million years of panicoid grass evolution.

    Science.gov (United States)

    Estep, M C; DeBarry, J D; Bennetzen, J L

    2013-02-01

    Sample sequence analysis was employed to investigate the repetitive DNAs that were most responsible for the evolved variation in genome content across seven panicoid grasses with >5-fold variation in genome size and different histories of polyploidy. In all cases, the most abundant repeats were LTR retrotransposons, but the particular families that had become dominant were found to be different in the Pennisetum, Saccharum, Sorghum and Zea lineages. One element family, Huck, has been very active in all of the studied species over the last few million years. This suggests the transmittal of an active or quiescent autonomous set of Huck elements to this lineage at the founding of the panicoids. Similarly, independent recent activity of Ji and Opie elements in Zea and of Leviathan elements in Sorghum and Saccharum species suggests that members of these families with exceptional activation potential were present in the genome(s) of the founders of these lineages. In a detailed analysis of the Zea lineage, the combined action of several families of LTR retrotransposons were observed to have approximately doubled the genome size of Zea luxurians relative to Zea mays and Zea diploperennis in just the last few million years. One of the LTR retrotransposon amplification bursts in Zea may have been initiated by polyploidy, but the great majority of transposable element activations are not. Instead, the results suggest random activation of a few or many LTR retrotransposons families in particular lineages over evolutionary time, with some families especially prone to future activation and hyper-amplification.

  20. Remifentanilo vs. bloqueo central epidural para control del dolor postoperatorio en cirugía vascular de urgencias Remifentanyl versus epidural central blockade for the management of postoperative pain in emergency vascular surgery

    Directory of Open Access Journals (Sweden)

    A. Quirante

    2004-12-01

    Full Text Available El correcto tratamiento del dolor postoperatorio constituye una prioridad dentro de los objetivos del anestesiólogo. En pacientes con patología vascular severa quirúrgica, el tratamiento analgésico efectivo se suele realizar mediante bloqueo continuo epidural. Sin embargo, la administración de analgésicos, tanto opiáceos como no opiáceos, por vía intravenosa, es una alternativa a la vía epidural cuando esta es desestimada. Caso clínico: Presentamos el caso de un paciente varón de 63 años portador de un bypass fémoro-poplíteo a primera porción en miembro inferior izquierdo, el cual es intervenido quirúrgicamente y con carácter urgente tras el diagnóstico de falso aneurisma séptico de arteria iliaca izquierda con rotura de anastomosis fémoro-poplítea. Se optó por una anestesia general basada en la analgesia con remifentanilo frente a bloqueo central epidural dado el carácter urgente de la cirugía y la ingesta habitual de antiagregantes plaquetarios. Se planificó como estrategia analgésica postoperatoria la administración de remifentanilo a dosis sedoanalgésicas (Introduction: The appropriate management of postoperative pain is a priority among the objectives of the anesthesiologist. In patients with severe surgical vascular pathology, an effective analgesic treatment is usually provided with epidural continuous blockade. However, the intravenous administration of analgesics, either opiates or non opiates, is an alternative to the epidural route when this has to be dismissed. Clinical case: We present the case of a 63-years old male patient carrying a femoro-popliteus bypass in the first portion of the left lower limb that underwent emergency surgery after being diagnosed of a false septic aneurysm in the left iliac artery with breakage of the femoro-popliteus anastomosis. General anesthesia based on remifentanyl was decided instead of epidural central blockade due to the urgent nature of the surgery and the regular

  1. Comunicado acerca de las Sustancias que Producen Drogadicción

    Directory of Open Access Journals (Sweden)

    Academia Nacional de Medicina

    1994-09-01

    Full Text Available

    Informe y conclusiones de la Comisión designada por la Academia Nacional de Medicina para el estudio sobre DROGADICCIÓN, integrada por los Académicos Roberto De Zubiría, Coordinador; José Francisco Socarrás, Enrique Núñez Olarte, Mario Camacho Pinto, Guillermo Sánchez Medina y con intervención del Académico Fernando Sánchez Torres.

    La Comisión nombrada por la presidencia de la Academia Nacional de Medicina de Colombia para redactar las conclusiones sobre los trabajos presentados acerca de las sustancias que producen drogadicción, se ha reunido en varias oportunidades y determinado proponer a la consideración de la Academia las siguientes conclusiones:

    1. La drogadicción es una enfermedad neuropsicológica y social cuyo desarrollo frecuente suele ser el consumo abusivo de drogas para sentirse en condiciones placenteras y evitar el dolor o malestar corriente en la adaptación a las variedades ambientales y en consecuencia del trabajo o de las pesadumbres de la vida corriente. Es bien sabido que en el cerebro existen seis grupos de receptores opiáceos, de los cuales uno regula la conducta emocional, otro la percepción del dolor, y uno más la disforia, todo lo cual provoca las modificaciones respectivas en el comportamiento.

    2. Los farmacodependientes tienen un perfil caracterológico distorsionado; inmadurez flagrante, poderosas tendencias narcisistas y autodestructivas, exigencia a vivir sólo el presente de modo agradable y gratificante, incapacidad para enfrentar tensiones ante las cuales emplean la evasión y la negación de la realidad, mediante mecanismos imaginativos, para lo cual ciertas drogas son de una ayuda inigualable.

    3. Lo anterior implica que todo farmacodependiente requiere tratamiento médico, psiquiátrico y social, teniendo en cuenta la clase de fármacos a la que es adicto. Tales fármacos son los siguientes: a Los depresores que provocan dependencia física y

  2. Redução do efeito analgésico da estimulação elétrica nervosa transcutânea de baixa freqüência em ratos tolerantes à morfina Reduction in analgesic effect from low-frequency transcutaneous electrical nerve stimulation in morphine-tolerant rats

    Directory of Open Access Journals (Sweden)

    MA Resende

    2006-09-01

    Full Text Available OBJETIVO: Investigar o efeito da TENS de baixa (10 Hz e alta freqüência(130 Hz aplicadas na pata inflamada do rato após tratamento crônico com morfina. MÉTODO: Foram utilizados 140 ratos Holtzman fêmeas, nos quais a carragenina (Cg 250 µg/0,1ml foi administrada na pata posterior direita para a indução da inflamação. TENS de baixa e alta freqüência foi aplicada por 20 min, após 2 h e 30 min da Cg e seu efeito medido através do método de Randall-Selitto. O antagonista opióide Naltrexona (3mg/kg,sc, foi administrado 30 minutos antes da TENS para verificar a liberação de substâncias opióides endógenas. A tolerância foi obtida após administração da morfina (10 mg/kg,sc, duas vezes ao dia, durante sete dias. O tratamento com TENS de baixa e alta freqüência foi realizado no oitavo dia às 2 h e 30 min após Cg. A análise estatística foi feita pelo método da análise de variância ANOVA (One Way seguido de um teste "post hoc" (Teste de Bonferroni, com nível de significância quando p OBJECTIVE: To investigate the effects of low (10 Hz and high-frequency (130 Hz transcutaneous electrical nerve stimulation (TENS applied to inflamed paws of rats following chronic treatment with morphine. METHOD: 140 female Holtzman rats were utilized. Carrageenan (250 µg/0.1 ml was administered to the right hind paws to induce inflammation. Two and a half hours after carrageenan injection, low and high frequency TENS was applied to the inflamed paw for 20 min, and its effect was measured via the Randall-Selitto method. The opioid antagonist naltrexone (3.0 mg/kg, subcutaneously was administered 30 min before TENS, to verify the release of endogenous opioids. Morphine tolerance (10 mg/kg, subcutaneously was induced by twice-daily injection over seven days. Low and high frequency TENS treatment was carried out on the eighth day, 2.5 hours after carrageenan injection. Statistical analysis was performed using one-way analysis of variance (ANOVA

  3. Samario-153-Lexidronam (EDTMP en el tratamiento de las metástasis óseas Samarium-153-Lexidronam (EDTMP for the management of bone metastases

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    F. Torre

    2004-02-01

    Full Text Available Las metástasis óseas son una complicación frecuente en pacientes neoplásicos, en este sentido, el tejido óseo ocupa el tercer lugar de todos los órganos y sistemas con metástasis después del pulmón e hígado. Aproximadamente un 75% de los enfermos con metástasis óseas sufrirán dolor, siendo estas la causa más frecuente de dolor en pacientes con cáncer. El dolor óseo aumenta con los movimientos y a la presión, limitando la autonomía del enfermo y su calidad de vida. El tratamiento incluye varios abordajes terapéuticos complementarios entre sí, como AINE, opiáceos, bifosfonatos, radioterapia, radioisótopos, cirugía y técnicas intervencionistas. Presentamos dos casos clínicos, el primero una mujer diagnosticada de carcinoma de mama y el segundo un hombre con adenocarcinoma de próstata y carcinoma vesical, ambos casos con diseminación metastásica ósea. Ante la persistencia del dolor y la dificultad en su control fueron tratados con Samario-Lexidronam (Sm-153, Quadramet® con resultados satisfactorios. Se consiguió disminuir el dolor, también el descenso en el consumo de opiáceos a pesar de la progresión de la enfermedad. El Sm-153 es un radioisótopo emisor de radiaciones beta y gamma. Presenta una semivida física corta, una alta afinidad por el esqueleto óseo y una eliminación urinaria. El alivio del dolor es del 65-80%, el inicio de la analgesia es rápido y la duración de esta es de 8 a 12 semanas con escasos efectos secundarios.Bone metastases are a frequent complication in cancer patients. Bone tissue ranks third, after lung and liver, of all the organs and systems with metastases. Approximately 75 per cent of patients with bone metastases will suffer pain, this being the most frequent cause of pain in cancer patients. Bone pain increases with movement and pressure, restricting patient autonomy and quality of life. The treatment includes several complementary therapeutic regimes: NSAIs, opiates

  4. Remifentanil na prática clínica Remifentanil en la práctica clínica Remifentanil in the clinical practice

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    Rogério Luiz da Rocha Videira

    2004-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O remifentanil é o opióide mais recentemente introduzido na prática anestésica. O objetivo desse estudo foi rever a literatura, com ênfase na informação de interesse clínico publicada no período de janeiro de 2000 a dezembro de 2002. CONTEÚDO: Os principais estudos sobre remifentanil são descritos e agrupados por áreas de interesse para a anestesia clínica. Aspectos como dose recomendada, equipamento e forma de uso, analgesia de transição e áreas em que o uso ainda é controverso, como para sedação, cirurgia pediátrica, obstétrica e terapia intensiva, são discutidos. CONCLUSÕES: O remifentanil é atualmente o opióide mais adequado para administração por infusão venosa contínua e pode tornar mais eficiente a prática clínica do anestesiologista ao serem seguidas as recomendações para o seu uso.JUSTIFICATIVA Y OBJETIVOS: El remifentanil es el opioide más recientemente introducido en la práctica anestésica. El objetivo de ese estudio fue rever la literatura, con énfasis en la información de interés clínico publicada en el período de enero de 2000 a diciembre de 2002. CONTENIDO: Los principales estudios sobre remifentanil son descritos y agrupados por áreas de interés para la anestesia clínica. Aspectos como dosis recomendada, equipamiento y forma de uso, analgesia de transición y áreas en que el uso aún es controvertido, como para sedación, cirugía pediátrica, obstétrica y terapia intensiva, son discutidos. CONCLUSIONES: El remifentanil es actualmente el opioide más adecuado para la administración por infusión venosa continua y puede hacer más eficiente la práctica clínica del anestesista a partir del momento en que sean seguidas las recomendaciones para su uso.BACKGROUND AND OBJECTIVES: Remifentanil is the newest opioid for anesthetic procedures. This study aimed at reviewing the literature, with emphasis on information of clinical interest published from January 2000

  5. Do opioid receptors play a role in the pathogenesis of the inflammatory response in acute pancreatitis? Os receptores opioides desempenham papel na patogênese da resposta inflamatória na pancreatite aguda?

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    Artur Penido

    2012-09-01

    Full Text Available PURPOSE: To investigate the effect of the opioid blocker naltrexone in the inflammatory response in acute pancreatitis (AP. METHODS: Acute pancreatitis was induced in anesthetized male Wistar rats by retrograde injection of 2.5% sodium taurocholate diluted in 0.5ml saline into the main pancreatic duct. Animals were randomized to the following experimental groups: Control Group (n=9: animals received an intraperitoneal injection of saline solution (0.5ml, 15 minutes before the induction of AP. Naltrexone Group (n=9: animals received an intraperitoneal injection of naltrexone 0.5ml (15 mg/kg, 15 minutes before induction of AP. Peritoneal levels of TNF-α and serum levels of IL-6 and amylase were determined The volume of the ascitic fluid was also evaluated. Myeloperoxidase (MPO activities were analyzed in homogenates of pulmonary tissue. RESULTS: There were no significant differences in the ascitic fluid volume, nor in TNF-a and IL-6 levels in the naltrexone group compared to controls. Treatment with naltrexone did not affect the lung MPO activity compared to control group. CONCLUSIONS: The opioid receptors don't play an important role in the pathogenesis of the inflammatory response in acute pancreatitis. If opioids affect leukocytes inflammatory signaling, there are no major implications in the pathogenesis of acute pancreatitis.OBJETIVO: Investigar o efeito do bloqueador opióide naltrexone na resposta inflamatória da pancreatite aguda. METODOS: Pancreatite aguda foi induzida em ratos machos Wistar, através de injeção retrógada de solução de taurocolato de sódio a 2,5% nos ductos pancreáticos. Os animais foram alocados em dois grupos: Grupo controle (n=9 animais receberam 0,5 ml de solução salina intra-peritonial 15 minutos antes da indução da pancreatite aguda e Grupo naltrexone (n=9 animais receberam naltrexone (15mg/kg de peso, em 0,5 ml de volume final por via intraperitoneal, 15 minutos antes da indução da pancreatite aguda

  6. Asociación de otras drogas de abuso en la intoxicación por cocaína

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    JL Echarte Pazos

    2011-01-01

    Full Text Available El objetivo del presente trabajo ha sido llevar a cabo un análisis de las urgencias atendidas en un hospital urbano de tercer nivel que se han relacionado con el consumo de cocaína. Para ello se ha realizado un estudio retrospectivo, con exclusión del área de pediatría y ginecología, durante los años 2005 y 2006. Se revisaron todas las asistencias clínicas que consultaron por intoxicación por cocaína. Los datos fueron analizados con el paquete estadístico SPSS 15.0 para windows. Durante el periodo de estudio se produjeron 1.531 intoxicaciones (1,2% del total de las urgencias. De éstas, 327 eran por cocaína (21,4% de las intoxicaciones. La edad media fue de 31 (8 años y la moda de 26 años. Un 76,5% eran varones. El 69,1% ingresaron en ambulancia. La mayor afluencia se produjo en fin de semana (46,8% y en horario nocturno (54,1%. El 53,2% eran consumidores habituales y el 25,4% esporádicos. Un 55,7% asociaron más de 2 drogas: el 53,5% alcohol, el 31,2% opiáceos, el 17.4% benzodiacepinas, el 17,1% cannabis, el 11,3% GHB y el resto otras drogas. El 77,1% consumieron en un lugar público. Tenían antecedentes de intoxicaciones previas un 59,3%. El 93% presentaban síntomatología: (52,6% neurológicos, 48% conductuales, 28,4% cardiovasculares, 19% respiratorios y 8,3% digestivos. Se administraron antídotos a un 20,5%. El destino final fue alta en las primeras 12 horas en el 60,9%, con solo un 5,7% de ingresos. Se realizó valoración psiquiátrica en el 21,1%. En conclusión, el perfil del usuario que consulta por intoxicación por cocaína es un varón de 26 años traído en ambulancia de un lugar público, en fin de semana, en horario nocturno, consumidor habitual, con sintomatología cardiológica y neurológica y dado de alta en menos de 12 horas. La intoxicación aguda por cocaína no es pura. Destaca la asociación de alcohol, opiáceos y benzodiacepinas. Menos de una cuarta parte fueron valorados por Psiquiatría. Palabras

  7. Bloqueio do plexo lombar no compartimento do psoas para analgesia pós-operatória em cirurgias ortopédicas Lumbar plexus blockage on psoas compartment for postoperative analgesia after orthopaedic surgeries

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    Luiz Eduardo Imbelloni

    2008-01-01

    Full Text Available OBJETIVOS: O plexo lombar foi localizado entre os músculos quadrado lombar e psoas maior. O objetivo deste estudo foi avaliar a eficácia da injeção única de bupivacaína 0,25% através do bloqueio do compartimento do psoas na analgesia pós-operatória em pacientes de cirurgias ortopédicas. MÉTODO: Quarenta pacientes receberam bloqueio do plexo lombar no compartimento do psoas através da localização com estimulador de nervos e injeção de bupivacaína a 0,25%. Avaliou-se a analgesia e a intensidade da dor às 4, 8, 12, 16, 20 e 24 horas após o término da cirurgia, assim como opióides de resgate. RESULTADOS: Os nervos ilioinguinal, genitofemoral, cutâneo femoral lateral, femoral e obturatório foram bloqueados em 90% dos pacientes. O bloqueio reduziu o regaste de opióides administrados, sendo que 52,5% dos pacientes não necessitaram de complementação analgésica, com duração de 24 horas. Não foram observados sinais e sintomas clínicos da toxicidade da bupivacaína, nem seqüelas associadas com o bloqueio dos nervos. CONCLUSÕES: Este estudo mostra que a injeção no espaço do compartimento do psoas é fácil de realizar com efetivo bloqueio dos cinco nervos. O bloqueio do plexo lombar no compartimento do psoas pode ser recomendado para o uso na analgesia pós-operatória após cirurgias ortopédicas.OBJECTIVES: The lumbar plexus is located between the quadratus lumborum and the psoas major muscles. The aim of this study was to evaluate the efficacy of a single 0.25% bupivacaine injection through the psoas compartment blockage in postoperative analgesia of patients undergoing orthopedic surgery. METHODS: 40 patients received lumbar plexus blockage at the psoas compartment through nerve stimulator and a 0.25% bupivacaine 40-ml injection. Analgesia and pain severity were evaluated at 4, 8, 12, 16, 20 and 24 hours after surgery, similarly to rescue opioids. RESULTS: The ilioinguinal, genitofemoral, lateral cutaneous of the

  8. Incidência de tremor em anestesia peridural com ou sem fentanil: estudo comparativo

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    Abreu Múcio Paranhos de

    2004-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A maioria dos trabalhos encontrados na literatura, relacionando a influência dos opióides administrados por via peridural com o tremor intra e pós-operatório, foram realizados com grupos de pacientes obstétricas, nas quais a resposta do centro termorregulador pode ser diferente das pacientes não grávidas. O objetivo deste trabalho foi comparar o bloqueio peridural com e sem fentanil, quanto à incidência de tremores e outras complicações no intra e pós-operatório em pacientes submetidos à cirurgia de varizes sob anestesia peridural com bupivacaína a 0,5% com adrenalina a 1:200.000. MÉTODO: Trinta e quatro pacientes, estado físico ASA I e II, submetidos à cirurgia para tratamento de varizes de membros inferiores, foram divididos aleatoriamente em 2 grupos (n = 17, e receberam midazolam (0,05 mg.kg-1, por via venosa seguido de anestesia peridural lombar, utilizando-se no grupo S, 20 ml bupivacaína a 0,5% (com vasoconstritor associado a 2 ml de solução fisiológica a 0,9% e no grupo F, 20 ml de bupivacaína a 0,5% (com vasoconstritor associada ao fentanil (100 µg. Foram estudados: incidência de tremor, temperatura dos pacientes, necessidade do uso de meperidina, e a incidência de náuseas e vômitos nos seguintes momentos: M1 - admissão do paciente na sala de operação; M2 - imediatamente antes da anestesia; M3 - 30 minutos após o término da injeção do anestésico local; M4 - 60 minutos após o término da injeção do anestésico local; M5 - 90 minutos após o término da injeção do anestésico local; M6 - final da anestesia; M7 - antecedendo a alta da sala de recuperação pós-anestésica. RESULTADOS: Quanto aos dados antropométricos, estado físico, tempo médio de duração da anestesia e cirurgia, temperatura dos pacientes e da sala de operação e incidência de náuseas e vômitos não houve diferença estatística entre os grupos. Houve diferença estatística aos 60 minutos (M4 e

  9. DANCE AND SHAMANISM: MITH-RITUALISTIC EDUCATIONAL PROCESS IN GUARANI’S EVERYDAY LIFE

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    Ana Luisa Menezes

    2008-06-01

    Full Text Available Este artigo busca desenvolver uma reflexão sobre a dança Guarani e o xamanismo, enfocando os aspectos mitológicos e ritualísticos dentro de um processo educativo e cotidiano. Na dança, a consciência da coletividade é vivenciada através do pensamento e do sentimento. A vivência provocada pelo coletivo na dança pode ser traduzida como nhandereté, corpo de todos, como divina e produtora de alegria. Nas intempéries do cotidiano, o Guarani produz beleza e alegria, porque são a expressão de suas identidades divinas. Através de conversas e depoimentos com os jovens Guaranis, buscou-se enfocar as elaborações feitas por estes, do conhecimento mitológico e da vivência cotidiana.O rito cumpre uma função vivificadora do mito e estes dois aspectos são percebidos como entrelaçados à dança e à Opy. Todos estes aspectos são vividos pelos jovens e adultos de uma forma muito inquietante que os levam à um movimento permanente de indagações, buscas e redefinições. Dentro desse processo, a Opy, o Karaí e a dança são destacadas como fundantes da cultura Guarani e servem como pontos de estabilização dentro de um cotidiano tão dinâmico. A dança, enquanto rito, transporta os Guaranis a um tempo de reconhecimento de suas identidades, de um ritmo de vida. O rito Guarani está ligado a uma estrutura profunda de organização coletiva emocional, dentro de uma função vital, de elevação espiritual e uma integração ao seu sistema de pertença. Para os Guaranis, Nhanderú ensinou a dança e mandou dançar a dança. Esta surge de uma percepção mitológica e o seu surgimento confunde-se com a própria existência Guarani. A espiritualidade nasce de uma relação vital, de movimento.A educação xamânica é apreendida pelos sentidos. A noção principal de conhecimento é o Arandurekó, conhecimento que se aprende ao longo da vida, num tempo-ritmo próprio. A dança-rito possibilita a conexão entre corpo e espírito, proporcionando

  10. Dr. House: Patología dual en el médico

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    Mariano A. BELLINA

    2016-09-01

    Full Text Available Dr. House es una serie dramática estadounidense cuyo personaje central es el Dr. Gregory House, médi? co que dirige una unidad de diagnóstico (con otros tres doctores en el Hospital Universitario Princeton? Plainsboro, en Nueva Jersey. Dr. House utiliza un proceso lógico especial como base para llegar al diagnóstico. La Unidad que dirige el Dr. House trata pacientes que han sido evaluados previamente por otros doctores sin haber alcanzado un diagnóstico. Los diagnósticos oscilan desde algunos muy comunes a enfermedades raras. House no respeta las reglas y procedimientos comunes en la Medicina tradicional, tiene conflictos interpersonales graves (así como falta de empatía y no muestra interés por otras prácticas clínicas que no sean las suyas. Sufre un dolor crónico intenso en la pierna derecha por el que comienza a prescribirse Vicodin® (hidrocodona, al que acaba haciéndose dependiente. Nuestra hipótesis es que House es un caso típico de patología dual, PD (coexistencia de trastorno por uso de sustancias y otra enfermedad mental, en concreto: de dependencia de opiáceos y trastorno mixto de personalidad (comparte rasgos del trastorno de la personalidad antisocial y narcisista. La PD no es infrecuente en médicos dada la demora en pedir ayuda y la fácil accesibilidad a algunas sustancias.

  11. Avaliação e alívio da dor no recém-nascido

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    Erica da Paixão Crescêncio

    2009-03-01

    Full Text Available Este estudo buscou identificar como os enfermeiros de unidade neonatal avaliam a dor no recém-nascido e quais asmedidas realizadas por eles para alívio da dor. Trata-se de um estudo quantitativo, transversal, com 32 enfermeirosque trabalhavam na unidade neonatal de um hospital particular do município de São Paulo, e que responderam a umformulário sobre a avaliação e condutas realizadas na dor do recém-nascido. Dentre os parâmetros citados pelosenfermeiros para a avaliação da dor, a expressão facial e o choro foram as mais citadas, seguido de alteração desinais vitais, agitação e os parâmetros utilizados na escala NIPS (fisiológicos e comportamentais. Os métodosfarmacológicos mais citados pelos profissionais para o alívio da dor do RN foram o uso de analgésicosantiinflamatórios não-esteroidais, os opóides potentes, sedativos, os opiódes fracos e os anestésicos locais. E ostratamentos não farmacológicos de alívio da dor foram a mudança de decúbito, seguido de massagem local, sucçãonão nutritiva (chupeta ou dedo enluvado e o banho de imersão. Assim, conclui-se que os enfermeiros avaliam a dorpela expressão facial e o choro. E utilizam analgésico antiinflamatório não-esteroidal, a mudança de decúbito, amassagem local e a sucção não nutritiva para alívio da dor.

  12. Uso não-médico de medicamentos psicoativos entre escolares do ensino fundamental e médio no Sul do Brasil

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    Tatiane da Silva Dal Pizzol

    2006-01-01

    Full Text Available O objetivo do presente estudo é investigar a prevalência de uso não-médico de medicamentos entre escolares da rede de ensino público e privado de Passo Fundo, Rio Grande do Sul, Brasil, e sua distribuição em relação a fatores sócio-demográficos. Por meio de um delineamento transversal, foi aplicado um questionário de autopreenchimento a 5.057 estudantes a partir da quinta série do ensino fundamental até o terceiro ano do ensino médio. O questionário continha perguntas sobre o uso, sem receita médica, de anfetamínicos, ansiolíticos, barbitúricos, anticolinérgicos, opiáceos, orexígenos e anabolizantes. Da amostra, 7,7% consumiram ansiolíticos alguma vez na vida, 6,4% consumiram anfetamínicos, 2,2%, anabolizantes, e 1,1%, barbitúricos. Estudantes do sexo feminino apresentaram maior consumo de ansiolíticos e anfetamínicos, enquanto que o consumo de anabolizantes foi maior no sexo masculino. O padrão de consumo de medicamentos psicoativos é semelhante ao observado em adultos, sugerindo a necessidade de inclusão de crianças e adolescentes nas campanhas educativas para prevenção do uso indevido de medicamentos.

  13. The effect of baclofen on spontaneous and evoked behavioural expression of experimental neuropathic chronic pain Efeito do baclofeno sobre a expressão comportamental espontânea e evocada da dor crônica neuropática experimental

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    TEREZINHA DE JESUS T. SANTOS

    1999-09-01

    Full Text Available Baclofen (beta-p-chlorophenyl-GABA has been used in humans to treat spasticity, as well as trigeminal neuralgia. Since GABA (gamma-aminobutyric acid has been implicated in inhibitory and analgesic effects in the nervous system, it was of interest to study the effect of baclofen in experimental neuropathic pain. With this purpose, experiments were carried out in 17 neuropathic rats with constrictive sciatic injury, as described by Bennet and Xie (1988, taking as pain parameters scratching behaviour and the latency to the thermal nociceptive stimulus. The results showed that baclofen induces, in a dose-dependent manner, significant decrease (p O baclofeno (beta-p-clorofenil-GABA é usado em seres humanos para tratar espasticidade, assim como neuralgia do trigêmeo. Como o GABA (ácido amino-gama-butírico tem sido implicado em efeitos inibitórios e analgésicos no sistema nervoso, tornou-se de interesse estudar o efeito do baclofeno em dor neuropática experimental. Com esse objetivo, foram realizados experimentos em 17 ratos neuropáticos com lesão constritiva do nervo ciático, como descrito por Bennet e Xie (1988, tomando como parâmetros de dor o comportamento de coçar-se (scratching e a latência ao estímulo térmico nociceptivo. Os resultados mostraram que o baclofeno induziu, de forma dose-dependente, diminuição significativa (p < 0,05 do comportamento de coçar-se e aumento significativo (p < 0,05 da latência ao estímulo térmico nociceptivo. A ausência de antagonismo pela naloxona sugere a não participação de mecanismo opióide-mediado nesse efeito analgésico do baclofeno em dor neuropática experimental.

  14. Intoxicación aguda por heroína

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    Guillermo Porras-Morales

    2004-03-01

    Full Text Available La intoxicación por opiáceos se presenta casi siempre como consecuencia de una sobredosis accidental de un derivado de éstos, usualmente la heroína por inyección. Otras formas de intoxicación, a las que no somos ajenos en nuestro medio, son los llamados correos de drogas, "body packers" o mulas, utilizados en el tráfico internacional de transporte de drogas. En estos casos la droga es generalmente tragada, envuelta en condones, que pueden contener heroína o cocaína. Su ruptura puede conducir a toxicidad severa y letal. Los antecedente de un viaje reciente en avión en un paciente con cuadro clínico de intoxicación, pueden justificar la indicación de una radiografía de abdomen como método diagnóstico e incluso la cirugía para limpieza intestinal como parte de su abordaje terapéutico.Most of opioid related deaths for overdose are accidental and are primarily due to intravenous heroin use. Other forms of poisoning may occur in the so called body packers ("mulas", who are used in international drug transportation. These patients generally swallow small quantities of wrapped cocaine or heroin in an attempt to smuggle the drugs across international borders. Their breakage can lead to severe and lethal toxicity. The history of a recent a flight in a patient with a clinical syndrome of poisoning, should justify the indication of abdominal x-rays for diagnosis and also surgery for "intestinal cleaning" as part of his therapeutic approach.

  15. Diario de una vida que no pudo ser: Estudio fenomenológico sobre la drogodependencia

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    Juan M. Leyva-Moral

    Full Text Available Justificación: El profesional de enfermería juega un papel crucial en la atención a las personas drogodependientes ya que son la puerta de entrada al conocimiento de las familias, del barrio y de los jóvenes. Conocer dicha realidad puede resultar útil para diseñar estrategias de promoción de la salud así como campañas de prevención. Objetivo: El objetivo de este estudio es conocer el significado que la persona drogodependiente atribuye a su drogadicción. Diseño: Estudio cualitativo con un enfoque fenomenológico. Metodología: Carmen es una mujer de 41 años, adicta a opiáceos desde los 17 años, ingresada en la Unidad de Patología Dual de un centro neuropsiquiátrico en Barcelona, durante el mes de septiembre de 2006. Para la recogida de datos se utilizó un diario semi-estructurado. Resultados: Se describe la drogadicción como algo negativo, responsable de sentimientos de tristeza, fracaso, destrucción y un gran deterioro emocional secundario a los sentimientos de culpabilidad. La participante describe este fenómeno en tres fases: uso-abuso-adicción. Conclusión: El diario elaborado por Carmen permite conocer el significado de la drogadicción y del internamiento para su deshabituación.

  16. Development and use of a genitourinary pathology digital teaching set for trainee education

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    Li Li

    2010-01-01

    Full Text Available Background : Automated, high-speed, high-resolution whole slide imaging (WSI robots are becoming increasingly robust and capable. This technology has started to have a significant impact on pathology practice in various aspects including resident education. To be sufficient and adequate, training in pathology requires gaining broad exposure to various diagnostic patterns through teaching sets, which are traditionally composed of glass slides. Methods: A teaching set of over 295 glass slides has been used for resident training at the Division of Genitourinary Pathology, Department of Pathology, University of Pittsburgh Medical Center. Whole slide images were prepared from these slides using an Aperio ScanScope CS scanner. These images and case-related information were uploaded on a web-based digital teaching model. Results: The web site is available at: https://www.secure.opi.upmc.edu/genitourinary/index.cfm. Once logged in, users can view the list of cases, or search cases with or without diagnoses shown. Each case can be accessed through an option button, where the clinical history, gross findings are initially shown. Whole slide images can be accessed through the links on the page, which allows users to make diagnoses on their own. More information including final diagnosis will display when the diagnosis-button is clicked. Conclusion: The web-based digital study set provides additional educational benefits to using glass slides. Residents or other users can remotely access whole slide images and related information at their convenience. Searching and sorting functions and self-testing mode allow a more targeted study. It would also prepare residents with competence to work with whole slide images. Further, the model can be expanded to include pre-rotation and post-rotation exams, and/or a virtual rotation system, which may potentially make standardization of pathology resident training possible in the future.

  17. Apendagitis epiploica primaria: Clínica y evolución de 73 casos

    Directory of Open Access Journals (Sweden)

    Graciela M Vázquez

    2014-12-01

    Full Text Available La apendagitis epiploica primaria es una enfermedad relativamente infrecuente dentro de los diagnósticos diferenciales del abdomen agudo. Describimos las características clínicas y evolución de una serie de 73 casos de apendagitis epiploica primaria. Se realizó una búsqueda de imágenes ecográficas y tomográficas con diagnóstico de apendagitis en el sistema de información hospitalario electrónico del Hospital Alemán entre abril del 2007 y julio del 2013 y posteriormente se revisaron sus historias clínicas. Se incluyeron 73 casos; la edad promedio fue de 45 años (± 16, 54 (74% eran varones. El motivo de consulta fue dolor abdominal: en fosa ilíaca izquierda en 65 (el 89% de los casos; en fosa ilíaca derecha en seis (8% y en otras localizaciones en dos (3%. Se les realizó ecografía abdominal a 44 (60%, tomografía computarizada a 21 (29%, y ambos estudios a 8 (11%. En el 49% de los casos se solicitó interconsulta con el servicio de cirugía. Recibieron tratamiento con antibióticos 15 (21% pacientes, de los cuales el 73% fue indicado por un médico clínico. Recibieron tratamiento ambulatorio con antiinflamatorios no esteroides 67 (92%; dos requirieron cirugía laparoscópica, dos internación y dos opiáceos. La apendagitis epiploica es infrecuente dentro de los diagnósticos diferenciales de abdomen agudo, pero es una entidad que no debe ser desconocida por los médicos para prevenir intervenciones innecesarias y el uso excesivo de antibióticos.

  18. Controllable synthesis of conducting polypyrrole nanostructures.

    Science.gov (United States)

    Zhang, Xuetong; Zhang, Jin; Song, Wenhui; Liu, Zhongfan

    2006-01-26

    Wire-, ribbon-, and sphere-like nanostructures of polypyrrole have been synthesized by solution chemistry methods in the presence of various surfactants (anionic, cationic, or nonionic surfactant) with various oxidizing agents [ammonium persulfate (APS) or ferric chloride (FeCl3), respectively]. The surfactants and oxidizing agents used in this study have played a key role in tailoring the nanostructures of polypyrrole during the polymerization. It is inferred that the lamellar structures of a mesophase are formed by self-assembly between the cations of a long chain cationic surfactant [cetyltrimethylammonium bromide (CTAB) or dodeyltrimethylammonium bromide (DTAB)] and anions of oxidizing agent APS. These layered mesostructures are presumed to act as templates for the formation of wire- and ribbon-like polypyrrole nanostructures. In contrast, if a short chain cationic surfactant octyltrimethylammonium bromide (OTAB) or nonionic surfactant poly(ethylene glycol) mono-p-nonylphenyl ether (Opi-10) is used, sphere-like polypyrrole nanostructures are obtained, whichever of the oxidizing agents mentioned above is used. In this case, micelles resulting from self-assembly among surfactant molecules are envisaged to serve as the templates while the polymerization happens. It is also noted that, if anionic surfactant sodium dodeyl surfate (SDS) is used, no characteristic nanostructures of polypyrrole were observed. This may be attributed to the doping effect of anionic surfactants into the resulting polypyrrole chains, and as a result, micelles self-assembled among surfactant molecules are broken down during the polymerization. The effects of monomer concentration, surfactant concentration, and surfactant chain length on the morphologies of the resulting polypyrrole have been investigated in detail. The molecular structures, composition, and electrical properties of the nanostructured polypyrrole have also been investigated in this study.

  19. EVALUACIÓN PSICOLÓGICA DEL ABUSO DE FÁRMACOS OPIOIDES

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    José Luis Carballo

    2016-01-01

    Full Text Available El incremento de la preinscripción de fármacos analgésicos opioides se ha asociado a un aumento de las tasas de abuso y las consecuencias negativas asociadas a su uso inadecuado. Diversos organismos sanitarios internacionales recomiendan la realización de una evaluación global y multidisciplinar del paciente durante todo el proceso terapéutico con opiáceos, con el fin de identificar un posible abuso. Ante la ausencia de quías específicas en el ámbito sanitario español, el objetivo de este artículo ha sido presentar una propuesta de evaluación psicológica, en base a los principales instrumentos de evaluación, disponibles actualmente para evaluar el abuso de opioides. Se establecen pautas para el proceso de evaluación en función de las variables psicológicas que puedan predecir y mantener dicho abuso, clasificando todo ello en función del momento del proceso terapéutico en el que los pacientes se encuentren, Aunque existen instrumentos con buenas propiedades psicométricas, son necesarias futuras investigaciones para la adaptación, traducción y validación de éstos a población española. Al mismo tiempo son necesarios futuros estudios que profundicen en estrategias de prevención e intervención para reducir la probabilidad de abuso en pacientes tratados con fármacos opioides.

  20. Choroba kociego pazura – diagnostyka i leczenie

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    Małgorzata Wieczorek

    2011-08-01

    Full Text Available Choroba kociego pazura (cat scratch disease – CSD jest rzadkorozpoznawaną chorobą bakteryjną o różnym obrazie klinicznym.Najczęściej przebiega w postaci miejscowej limfadenopatii, u ok.50% pacjentów może wywoływać objawy choroby rozrostowej,w pojedynczych przypadkach mogą wystąpić objawy ze stronyukładu mięśniowo-szkieletowego: zapalenie kości, artropatia lubmialgia.W pracy przedstawiono opis bardzo wcześnie zdiagnozowanej klinicznie,potwierdzonej laboratoryjnie na podstawie badań serologicznychi molekularnych CSD u 10-letniego chłopca.Pierwsze objawy w postaci powiększenia węzłów chłonnych zaobserwowanopo 2–3 tygodniach od zadrapania okolicy lewego barkuprzez kota. W badaniu USG stwierdzono powiększenie, obrzęki przekrwienie węzłów chłonnych lewego ramienia i przedramienia.W 11. dobie wystąpiła gorączka o torze hektycznym. Zmianyw wynikach badań laboratoryjnych – przyspieszony OB i leukocytoza– pojawiły się dopiero w 14. dobie, w 21. dobie zaobserwowanozwiększenie stężenia białka C-reaktywnego (C-reactive protein– CRP. Wyniki pozostałych badań były w normie przez cały czastrwania choroby.Pomimo terapii cefetamet pivoxil rozpoczętej w 10. dobie choroby,w 16. dobie wytworzył się ropień w pobliżu węzła chłonnego okolicyłokciowej. Zmiany ustąpiły całkowicie po zabiegu chirurgicznymi zastosowaniu netylmycyny.

  1. Thelazia Callipaeda and Eye Infections

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    Otašević Suzana

    2014-09-01

    Full Text Available Infekcije oka mogu da izazovu metazoe-helminti. Dugo se za ove parazitoze verovalo da su rasprostranjene samo u tropskim krajevima sveta. U poslednje vreme najčešće su opisane subkonjuktivalne infekcije adultima ili nezrelim formama vrste D. repens, koje su filarije kanida i za koje je čovek samo slučajni nosilac. S obzirom na činjenicu da se na teritoriji grada Niša dijagnostikuje telazioza (thelasiosis kod pasa, opis morfoloških karakteristika roda, životnog ciklusa, rasprostranjenosti i kliničkog značaja ovog uzročnika zoonoza prvenstveno je bio cilj ovog rada. Rod Thelazia (Spirurida, Thelaziidae obuhvata kosmopolitsku grupu očnih crva spirurids, odgovornih za očne infekcije domaćih i divljih životinja i ljudi koje se prenose različitim vrstama mušica. Morfološki odrasli crvi su kremasto bele boje, končastog izgleda, dužine do 2 cm. Dokazano je da su muve reda Diptera, porodice Drosophilidae, roda Phortica, vektori i prelazni domaćini vrste T. callipaeda. Nematode lokalizovane u konjunktivalnom prostoru, suznim putevima i okolnim okularnim tkivima kanida, felida, glodara i ljudi, mogu izazvati blage simptome (pojačano suzenje, svrab, osećaj stranog tela, bol, otok, zamagljen vid, eksudativni konjunktivitis do onih jako ozbiljnih i teških (zamućenje i ožiljavanje konjunktive i rožnjače, ulceracije rožnjače i keratitis ukoliko se ne leče. Kako bi se obezbedila sigurna dijagnoza telazioze i sprovođenje odgovarajućeg tretmana primarnih problema i komplikacija, neophodno je kontinuirano medicinsko obaveštavanje i svest o ovoj infekciji.

  2. Tratamento farmacológico da dependência do álcool The pharmacologic treatment of the alcohol dependence

    Directory of Open Access Journals (Sweden)

    Luís André Castro

    2004-05-01

    Full Text Available As intervenções farmacológicas podem ter um papel crucial na redução do craving, consumo de álcool e manutenção da abstinência. Este artigo revisa a farmacoterapia para a dependência de álcool com ênfase na naltrexona, dissulfiram e acamprosato. O antagonista opióide naltrexona diminui taxas de recaída, reduz dias de consumo e prolonga períodos de abstinência. Acamprosato restaura a atividade normal dos sistemas glutamato e GABA. Dissulfiram tem demonstrado ser mais efetivo para pacientes que acreditam em sua eficácia e permaneçam aderentes ao tratamento. Ondansetron tem-se mostrado promissor na dependência de álcool de início precoce, mas necessita estudos mais extensivos. Topiramato (até 300 mg/dia foi mais eficaz do que placebo no tratamento da dependência de álcool.The pharmacological intervention can play a crucial role in the reduction of craving and drinking and the maintenance of abstinence. This article reviews pharmacotherapy for alcohol dependence with an emphasis on the naltrexone, dissulfiram and acamprosate. The opioid antagonist naltrexone lowers relapse rate, reduces drinking days and prolongs periods of abstinence. Acamprosate restores the normal activity of glutamate and GABA systems. Disulfiram has been shown to be most effective for patients who believe in its efficacy and remain compliant with the treatment. Ondansetron, has shown promise in the early-onset alcohol dependence but needs more extensive study. Topiramate (up to 300 mg per day was more efficacious than placebo in the treatment of alcohol dependence.

  3. Controle da dor no pós-operatório de cirurgia cardíaca: uma breve revisão

    Directory of Open Access Journals (Sweden)

    Luciano Ramos de Lima

    2008-06-01

    Full Text Available Este estudo teve como objetivo identificar as terapêuticas analgésicas para controle da dor no pós-operatório de pacientes submetidos à cirurgia cardíaca e os instrumentos utilizados para mensurar a experiência dolorosa. Trata-se de uma pesquisa bibliográfica realizada por meio de revisão da literatura nas bases de dados eletrônicos LILACS, revistas eletrônicas da SciELO, dissertações e teses. Foram utilizados os descritores analgesia, analgesia controlada pelo paciente, cirurgia cardíaca, avaliação e dor pós-operatória. O levantamento dos dados ocorreu em maio de 2007 e foram selecionados estudos publicados no período de maio de 1997 a maio de 2007. Na análise realizou-se síntese reflexiva dos estudos. Dos 23 estudos levantados foram utilizados 8 artigos e uma dissertação de mestrado. A técnica de analgesia mais utilizada foi a Analgesia Controlada pelo Paciente (ACP e os medicamentos mais utilizado foram os opióides, como a morfina, seguidos por antiflamatórios não esteroidais (AINEs e dipirona. Não foram encontrados estudos que utilizaram a terapêutica não farmacológica. Os instrumentos de avaliação de dor frequentemente utilizados nestes estudos incluíram as escalas unidimensionais como a escala numérica verbal e a escala analógica visual. Ficou também evidenciado que os enfermeiros estão pouco envolvidos em pesquisas que abordam o controle da dor no período pós-operatório de cirurgia cardíaca.

  4. Bases biológicas do transtorno de estresse pós-traumático Biological basis of posttraumatic stress disorder

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    Frederico G Graeff

    2003-06-01

    Full Text Available A pesquisa neuroendocrinológica dos sistemas fisiológicos envolvidos no estresse evidencia hiper função do eixo simpato-adrenal em conjunto com uma redução da atividade do eixo hipotálamo-hipófise-adrenal (HHA em pacientes com estresse pós-traumático (TEPT. Uma resposta prejudicada do cortisol aos estressores parece estar associada com um aumento da vulnerabilidade ao desenvolvimento do TEPT. O excesso de catecolaminas, sem o pareamento do aumento dos corticóides promoveria uma consolidação excessiva das memórias traumáticas e a indevida generalização para outras situações estressantes. Sintomas como o entorpecimento e flashbacks têm sido relacionados com o aumento de opióides endógenos. Estudos de neuroimagem evidenciam uma redução do volume hipocampal no TEPT, que tem sido relacionada a alterações cognitivas e anormalidades do eixo HHA encontrados no TEPT.Neuroendocrinological research on the physiological systems involved in stress evidenced hyper functioning of the sympatho-adrenal axis together with reduced activity of the hypothalamic-pituitary-adrenal axis in patients with posttraumatic stress disorder (PTSD. An impaired corticoid response to stressors seems to be associated with enhanced vulnerability to PTSD. Excess catecholamines, unchecked by corticoids would promote over consolidation of traumatic memories and undue generalization to other stressful situations. Symptoms such as numbing and flashbacks have been related to endogenous opioids. Neuroimaging studies evidenced a reduction of hippocampal volume in PTSD patients, which has been related to both cognitive changes and abnormalities of the HPA axis that are found in PTSD.

  5. Photoproduction of the kaon(+)kaon(-)(1750)

    Science.gov (United States)

    Mitchell, Ryan Edward

    2003-07-01

    While photoproduction has often been advertised as an important environment in which to study light meson spectroscopy, solid experimental results are sparse. In fact, beyond the relatively straightforward photoproduction of the rho, o, and φ mesons, the few results of exclusive photoproduction that do exist are poorly understood, and several, perhaps, have even been misinterpreted. After extensively reviewing the sometimes tenuous history of the exclusive photoproduction of the "rho'(1600)," the "opi0(1250)," the "o(1650)," and the "K+K -(1750)," new results from the E831/FOCUS photoproduction experiment at Fermilab are presented which address the interpretation of the K+K-(1750). This enhancement in low-pT K +K- pairs at a mass near 1750 MeV/c2 has been observed by several previous photoproduction experiments, but, despite several apparent inconsistencies, it has always been interpreted as the JPC = 1-- φ(1680) meson. With nearly two orders of magnitude more events than any previous observation of the K+ K-(1750), and based on precise measurements of its mass and width, and its absence from the K* K final state, the FOCUS data can finally render this interpretation implausible. In addition, several steps have been taken towards establishing a new interpretation. Based on limited angular analyses of its decay and the beam energy dependence of its production, we argue that, in the absence of any wild interference scenarios, the K+ K-(1750) has JPC ≠ 1--, and, in fact, the most likely assignment appears to be 2++. It is hoped that this work can help set the stage for future reevaluations and new insights in photoproduction.

  6. Analiza primene IMM algoritma za praćenje manevrišućih ciljeva / Analysis of IMM algorithm for maneuvering target tracking

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    Zvonko Radosavljević

    2005-05-01

    Full Text Available U radu je analizirana primena IMM algoritma sa tri modela Kalmanovih filtara, za praćenje cilja pomoću osmatračkog radara. Prvi Kalmanov filtar podešen je da prati ciljeve koji se kreću po pravolinijskoj trajektoriji bez ubrzanja, drugi prati ciljeve koji se kreću ubrzano i vrše blag manevar, a treći je namenjen za praćenje ciljeva koji se kreću ubrzano i vrše oštar manevar. Dat je opis algoritma kao i vrednosti odgovarajućih parametara i matrica prelaza za Kalmanove filtre, kao i uporedna analiza algoritma u odnosu na standardan Kalmanov filtar šestog reda. Prikazani rezultati srednje kvadratne greške praćenja po x i у koordinati pokazuju opravdanost izbora predložene metode praćenja. / This paper considers comparative analysis the problem of maneuvering target tracking to IMM algorithm with 3 standard Kalman filters and same standard Kalman filter 6. order, using data from TWS radar. The first Kalman filter from IMM algorithms is tuned for tracking of target moving along the rectilinear trajectory -without acceleration, the second tracks the targets with acceleration and gentle maneuver, and the third Kalman filter tracks the target with acceleration and sharp maneuver. The mathematical model of algorithm and values of appropriate parameters and Kalman filter matrices, are presented. The results of RMSE of tracking in x and у coordinates, show the validity of the proposed method.

  7. Consequence clauses with a meaning of measure and degree

    Directory of Open Access Journals (Sweden)

    Nikolić Marina M.

    2015-01-01

    Full Text Available The objective of this paper is to present a new classification of consequence clauses that is based on a category of degree. Based on that parameter, consequence clauses are classified into the ones that have a meaning of degree and the ones that don’t have that meaning. Furthemore, consequence clauses with a meaning of degree can be divided into the clauses with a meaning of measure (Napolju je toliko hladno da smo se odmah vratili iz šetnje./It is so cold outside that we had to return immediately back; On je takav prevarant, da će te sigurno preći/ He is such a chouse - he will cheat for sure. and into excessive clauses (Previše je debela da uđe u tu haljinu/ She is too fat to fit in this dress; Devojčica je premalena da ostane sama kod kuće/ The girl is too small to stay at home alone; Buka je bila dovoljna da natera dete u plač/The noise was loud enough to cause the baby cry. The article provides the arguments that the category of degree in this sentences is grammaticalized with the help of certain modifiers and a conjunction of result da. The author applies the onomasiological method in the analysis and uses the theory of semantic locations. An existence of certain meanings is confirmed by the transformational test. [Projekat Ministarstva nauke Republike Srbije, br. 178021: Opis i standardizacija savremenog srpskog jezika, potprojekat: Sintaksa složene rečenice

  8. LPL gene mutation as the cause of severe hypertriglyceridemia in the course of ketoacidosis in a patient with newly diagnosed type 1 diabetes mellitus.

    Science.gov (United States)

    Nocoń-Bohusz, Julita; Wikiera, Beata; Basiak, Aleksander; Śmigiel, Robert; Noczyńska, Anna

    2016-02-18

    Wstęp. Ciężka hipertrójglicerydemia to stan, w którym stężenie trójglicerydów (TG) przekracza 1000 mg/dl. Za zaburzenie to mogą odpowiadać mutacje w genie lipazy lipoproteinowej (LPL), apolipoproteiny C2 (APOC2) i apolipoproteiny A5 (APOA5) dziedziczone w sposób autosomalnie recesywny. Cel. W pracy przedstawiamy pacjenta, u którego manifestacji klinicznej cukrzycy towarzyszyła kwasica metaboliczna oraz skrajna hiperlipidemia. Opis pacjenta. 2,5 letni chłopiec przyjęty został do szpitala z kwasicą ketonową (pH – 7,0, BE -20 mmol/l , HCO3 10 mmol/l), stężeniem glukozy 850 mg%, hiponatremią (Na 100 mmol/l) oraz hiperlipidemią (trójglicerydy (TG) 13493 mg/dl, cholesterol całkowity (TC) 734 mg/dl). Zastosowano leczenie, uzyskując prawidłowe glikemie oraz normalizację zaburzeń lipidowych. U dziecka rozpoznano heterozygotyczną mutację genu LPL. Intensywna insulinoterapia i prawidłowe wyrównanie metaboliczne cukrzycy typu 1 gwarantują prawidłowy lipidogram u pacjenta do chwili obecnej. Wniosek. Rozpoznając skrajną hipertrójglicerydemię w kwasicy ketonowej w przebiegu cukrzycy typu 1, należy ostrożnie interpretować wyniki badań laboratoryjnych oraz dążyć do wykonania badania genetycznego u pacjenta, także u najbliższych jego krewnych.

  9. Detection of oligonucleotide hybridization on a single microparticle by time-resolved fluorometry: quantitation and optimization of a sandwich type assay.

    Science.gov (United States)

    Hakala, H; Mäki, E; Lönnberg, H

    1998-01-01

    Uniformly sized (50 micro m) porous glycidyl methacrylate/ethylene dimethacrylate particles (SINTEF) were used as the solid phase in a sandwich type mixed-phase hybridization assay based on time-resolved fluorescence detection on a single particle. These particles were coated with oligodeoxyribonucleotide probes by conventional phosphoramidite chain assembly. An oligodeoxyribonucleotide bearing a photoluminescent europium(III) chelate, ¿2,2',2",2"'-¿¿4'-¿4"'-[(4, 6-dichloro-1,3,5-triazin-2-yl)amino]phenyl¿-2,2':6',2"-terpyrid ine-6, 6"-diyl¿bis(methylenenitrilo)¿tetrakis(acetato)¿eur opi um(III), was hybridized to a complementary sequence of the target oligonucleotide, and the resulting duplex was further hybridized to the particle-bound probes. The latter binding was quantified by time-resolved measurement of the emission signal of a single particle. Kinetics of hybridization and the effect of the concentration of the target oligomer and the fluorescently tagged probe on the efficiency of hybridization were studied. The intensity of the emission signal was linearly related to the concentration of the target oligomer over a range of 5 orders of magnitude. The length of the complementary region between the target oligomer and the particle-bound probe was varied, and the effect of point mutations and deletions on the hybridization efficiency was determined in each case. The maximal selectivity was observed with 10-16-base pair complementary sequences, the optimal length depending on the oligonucleotide loading on the particle. Discrimination between the complete matches and point mismatches was unequivocal, a single point mutation and/or deletion decreasing the efficiency of hybridization by more than 2 orders of magnitude.

  10. en Pontevedra durante el año 2001

    Directory of Open Access Journals (Sweden)

    P. Fernández

    2005-01-01

    Full Text Available Se presenta un estudio epidemiológico de las intoxicaciones agudas por psicofármacos y drogas de abuso (excluyendo el alcohol, atendidas en el Servicio de Urgencias de adultos del Complejo Hospitalario de Pontevedra (CHOP durante el año 2001. Utilizando el test cualitativo de screening de drogas de abuso Triage TM8 (Biosite Diagnostics, se analizaron 554 orinas, de las cuales 318 resultaron positivas, lo que supone un 0,56% del total de urgencias atendidas en este Centro durante este año. Se observa un claro predominio de las intoxicaciones por psicofármacos (208 casos, seguidos de la cocaína (56 casos, marihuana (28 casos, opiáceos (16 casos y anfetaminas (10 casos. El 55% de los pacientes eran varones, con una edad media de 32,1 años. Entre los antecedentes registrados destaca la drogadicción (78 casos, el tratamiento previo con psicofármacos (60 casos y los antecedentes psiquiátricos (43 casos. Los síntomas neurológicos, en especial los derivados del deterioro del nivel de conciencia, fueron los más frecuentes (37%, relacionados mayoritariamente con el consumo de psicofármacos. El tratamiento más aplicado fue el inespecífico (54% y, aunque casi un 45% precisó ingreso hospitalario, su baja letalidad (<1% confirma el carácter banal y la evolución satisfactoria de la mayoría de los pacientes.

  11. Physiological and histopathological changes in the liver of male rats exposed to paracetamol and diazinon

    Institute of Scientific and Technical Information of China (English)

    Abdel-Tawab H Mossa; Tarek M Heikal; Enayat Abdel Aziz Omara

    2012-01-01

    Objective: The present study was conducted to evaluate the adverse effect of exposure to Diazinon (DIA) and Paracetamol (PARA) and their combination on male rats. Methods: Rats were orally administered PARA at a dose of 66.66 mg a.i. kg-1 body weight (maximum administration dose) and DIA at a dose 12.50 mg a.i. kg-1 b.wt. (1/100 LD50) for 28 consecutive days. Results:Significantly, decreased of body weights were observed in all treated groups, while significant increase in relative liver weight were recorded in DIA and DIA+PARA-treated groups compared to control rats. Liver dysfunction enzymes (e.g., aspartate aminotransferase, AST; alanine aminotransferase, ALT; alkaline phosphatase, ALP and lactate dehydrogenase, LDH) and Lipid Peroxidation Level (LPO) were increased in DIA, PARA and DIA+PARA-treated groups. Treatment of DIA and DIA+PARA caused significant decrease in the activity of serum Cholinesterase (ChE). PARA, DIA and PARA+DIA treatments caused histopathological changes and decreases in DNA content in liver cells of rats. The severities of such observations were more pronounced in their combined exposure. Conclusions: We can conclude that both paracetamol at maximum administration dose and diazinon caused biochemical and histopathological alteration in the liver of male rats. The severities of such observations were more pronounced in their combined exposure. The data throw light on the problem of simultaneous exposure to OPIs and commonly used drugs especially among agriculture sector workers in developing countries, where the handling of drugs (e.g., PARA) is mainly without medical prescription. Further studies, applied to pregnant women, newborns and childhood may be of great significance.

  12. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

    Directory of Open Access Journals (Sweden)

    Robyn D Moir

    2012-08-01

    Full Text Available The ability to store nutrients in lipid droplets (LDs is an ancient function that provides the primary source of metabolic energy during periods of nutrient insufficiency and between meals. The Fat storage-Inducing Transmembrane (FIT proteins are conserved ER-resident proteins that facilitate fat storage by partitioning energy-rich triglycerides into LDs. FIT2, the ancient ortholog of the FIT gene family first identified in mammals has two homologs in Saccharomyces cerevisiae (SCS3 and YFT2 and other fungi of the Saccharomycotina lineage. Despite the coevolution of these genes for more than 170 million years and their divergence from higher eukaryotes, SCS3, YFT2, and the human FIT2 gene retain some common functions: expression of the yeast genes in a human embryonic kidney cell line promotes LD formation, and expression of human FIT2 in yeast rescues the inositol auxotrophy and chemical and genetic phenotypes of strains lacking SCS3. To better understand the function of SCS3 and YFT2, we investigated the chemical sensitivities of strains deleted for either or both genes and identified synthetic genetic interactions against the viable yeast gene-deletion collection. We show that SCS3 and YFT2 have shared and unique functions that connect major biosynthetic processes critical for cell growth. These include lipid metabolism, vesicular trafficking, transcription of phospholipid biosynthetic genes, and protein synthesis. The genetic data indicate that optimal strain fitness requires a balance between phospholipid synthesis and protein synthesis and that deletion of SCS3 and YFT2 impacts a regulatory mechanism that coordinates these processes. Part of this mechanism involves a role for SCS3 in communicating changes in the ER (e.g. due to low inositol to Opi1-regulated transcription of phospholipid biosynthetic genes. We conclude that SCS3 and YFT2 are required for normal ER membrane biosynthesis in response to perturbations in lipid metabolism and ER

  13. Seasonal forecasts of drought indices in African basins

    Directory of Open Access Journals (Sweden)

    E. Dutra

    2012-09-01

    Full Text Available Vast parts of Africa rely on the rainy season for livestock and agriculture. Droughts can have a severe impact in these areas which often have a very low resilience and limited capabilities to mitigate their effects. This paper tries to assess the predictive capabilities of an integrated drought monitoring and forecasting system based on the Standard precipitation index (SPI. The system is firstly constructed by temporally extending near real-time precipitation fields (ECMWF ERA-Interim reanalysis and the Climate Anomaly Monitoring System-Outgoing Longwave Radiation Precipitation Index, CAMS-OPI with forecasted fields as provided by the ECMWF seasonal forecasting system and then is evaluated over four basins in Africa: the Blue Nile, Limpopo, Upper Niger, and Upper Zambezi. There are significant differences in the quality of the precipitation between the datasets depending on the catchments, and a general statement regarding the best product is difficult to make. All the datasets show similar patterns in the South and North West Africa, while there is a low correlation in the tropical region which makes it difficult to define ground truth and choose an adequate product for monitoring. The Seasonal forecasts have a higher reliability and skill in the Blue Nile, Limpopo and Upper Niger in comparison with the Zambezi. This skill and reliability depends strongly on the SPI time-scale, and more skill is observed at larger time-scales. The ECMWF seasonal forecasts have predictive skill which is higher than using climatology for most regions. In regions where no reliable near real-time data is available, the seasonal forecast can be used for monitoring (first month of forecast. Furthermore, poor quality precipitation monitoring products can reduce the potential skill of SPI seasonal forecasts in two to four months lead time.

  14. Avaliação do efeito antinociceptivo e da toxicidade aguda do extrato aquoso da Hyptis fruticosa Salmz. ex Benth Evaluation of the analgesic effect and acute toxicity of the aqueous extract of Hyptis fruticosa (Salmz. ex Benth.

    Directory of Open Access Journals (Sweden)

    Aline B.L. Silva

    2006-12-01

    Full Text Available Este trabalho descreve o efeito antinociceptivo e a toxicidade aguda do extrato aquoso das folhas da Hyptis fruticosa Salmz. ex Benth. (Lamiaceae. O extrato aquoso liofilizado, administrado por via oral, reduziu as contorções abdominais induzidas por ácido acético (200, 400 e 500 mg/kg e o tempo de reação dos animais na primeira fase do teste da formalina (100 mg/kg e 400 mg/kg. No teste da placa quente, o extrato aquoso aumentou o tempo de latência ao calor (100 e 200 mg/kg tendo este efeito sido revertido pelo antagonista opióide naloxona (5 mg/kg; i.p.. No ensaio de toxicidade aguda, não foi detectada a morte de nenhum animal após tratamento com doses de até 5 g/kg (v.o. do extrato. Em conclusão, os resultados obtidos indicam que o extrato aquoso da Hyptis fruticosa apresenta efeito antinociceptivo em camundongos e não apresenta toxicidade aguda nas doses testadas.The antinociceptive effect and the acute toxicity of Hyptis fruticosa leaves were evaluated through the administration of its aqueous extract in mice. The extract, administered orally (200, 400, and 500 mg/kg, reduced the nociceptive response in the writhing test as well as in the early phase of the formalin test (100 and 400 mg/kg and it increased the latency time in the hot plate test (100 and 200 mg/kg. The antinociceptive effect was reversed by naloxone (5 mg/kg, i.p.. Moreover, no animal deaths were observed in doses up to 5 g/kg. In conclusion, the aqueous extract of Hyptis fruticosa showed no acute toxicity at the evaluated doses and revealed antinociceptive effect in mice. Such effects are possibly associated with the opioid system activation.

  15. Genetic Differentiation of Archachatina marginata Populations from Three Vegetation Zones Using Radom Amplified Polymorphic DNA Polymerase Chain Reaction

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    Comfort O. AFOLAYAN

    2015-09-01

    Full Text Available The genetic differentiation of Archachatina marginata populations from three different zones of Nigeria was studied with a view to delimiting them into sub-species. One hundred and nineteen (119 snail specimens were collected, comprising of forty (40 specimens from Yenagoa (Mangrove forest and from Kabba (Guinea Savanna and thirty nine (39 specimens were from Ile-Ife (Rainforest. Eight parameters of the shell specimens of A. marginata which included height of shell, width of shell, aperture height, aperture width, spire length, spire width, penultimate whorl length and first whorl length were subjected to Principal Component Analysis (PCA and Canonical Variates Analysis (CVA to delimit the populations into sub-species. DNA of the various populations was extracted from the foot muscle using CTAB (Cetyl Trimethyl Ammonium Bromide method, which was subjected to RAPD analysis. The RAPD studies employed five (5 oligonucleotide primers (OPB – 17, OPH – 12, OPH – 17, OPI – 06 and OPU – 14 to amplify DNA from 27 samples of A. marginata selected. All five primers produced different band patterns, and the number of fragments amplified per primer varied. Among them, OPB- 17 gave DNA profiles with more numerous bands than the others primers. Both PCA and CVA produced overlapped clusters of A. marginata specimens from the three vegetation zones. The height of shell was observed to be the most variable feature and preferably the most suitable parameter for population grouping. Analysis of the proportions of polymorphic loci and band sharing based on similarity indices for A. marginata samples indicated a relatively high level of genetic variation in the populations from the three areas.

  16. Programas de mantenimiento de metadona con servicios auxiliares: un estudio de coste-efectividad

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    Puigdollers E.

    2003-01-01

    Full Text Available Objetivo: Actualmente, los programas de mantenimiento con metadona (PMM son la mejor alternativa de tratamiento para los adictos a opiáceos. Se pretende valorar el coste-efectividad de tres PMM que ofrecían diferentes servicios auxiliares utilizando como medida de efectividad el incremento de la calidad de vida. Métodos: Estudio de seguimiento a 12 meses de 586 pacientes que iniciaron tratamiento con metadona en los centros de atención y seguimiento municipales de Barcelona. Para medir la evolución de la calidad de vida se utilizó el Perfil de Salud de Nottingham (PSN. Se calcularon los costes unitarios estándar y el coste total por paciente a partir de los registros de actividad. Los datos sociodemográficos, de salud y toxicológicos se obtuvieron a través de una entrevista semiestructurada. El análisis coste-efectividad se realizó mediante dos modelos multivariados con idénticas variables de ajuste. Resultados: Cuanto mayor es la intensidad de programa, más elevado es el coste. Los modelos ajustados detectaron un aumento significativo de la calidad de vida (mejora de un 8% en el PSN y de los costes (17% entre el programa de intensidad baja y el de intensidad media. Conclusiones: El programa de media intensidad demostró la mejor relación coste-efectividad pero, dadas las limitaciones del estudio, es difícil ser taxativo en la generalización de sus resultados.

  17. Pancreatitis aguda necrotizante en una intoxicación fatal por metadona Acute necrotizing pancreatitis in a fatal poisoning with methadone

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    A. Sibón

    2004-01-01

    Full Text Available La pancreatitis necrotizante es una causa infrecuente de muerte súbita. La metadona, un fármaco empleado en el tratamiento sustitutivo de adictos a opiáceos, ha sido responsable de muertes tras su ingestión accidental por niños cuando estaba a su alcance, en intentos autolíticos o después de un período de abstinencia en pacientes con tolerancia. La muerte se debe a depresión del sistema nervioso central y depresión respiratoria. Reportamos un caso de muerte súbita con pancreatitis aguda necrotizante y hemorrágica, hemorragia suprarrenal y edema pulmonar en el contexto de una sobredosis por metadona en un paciente en programa de mantenimiento. Se descartaron otras causas frecuentes de pancreatitis como el alcoholismo crónico o la patología de tracto biliar. Discutimos la constelación de hallazgos para sugerir un posible mecanismo fisiopatológico.Necrotic pancreatitis is a rare cause of sudden death. Methadone, a drug used as a substitution treatment in heroin addicts, has been responsible for deaths after accidental ingestion by children of carelessly stored methadone, in suicide attempts or after a period of abstinence in tolerant patients. Death results from central nervous system and respiratory depression. We report a case of a sudden death with acute hemorrhagic and necrotizing pancreatitis, suprarenal haemorrhagia and pulmonary edema in the context of an overdose of methadone in a patient in an opioid maintenance program. Other frequent causes of pancreatitis such as chronic alcoholism and biliary tract disease were ruled out. We discuss the constellation of findings with regard to possible pathophysiological mechanisms.

  18. Yeast PAH1-encoded phosphatidate phosphatase controls the expression of CHO1-encoded phosphatidylserine synthase for membrane phospholipid synthesis.

    Science.gov (United States)

    Han, Gil-Soo; Carman, George M

    2017-08-11

    The PAH1-encoded phosphatidate phosphatase (PAP), which catalyzes the committed step for the synthesis of triacylglycerol in Saccharomyces cerevisiae, exerts a negative regulatory effect on the level of phosphatidate used for the de novo synthesis of membrane phospholipids. This raises the question whether PAP thereby affects the expression and activity of enzymes involved in phospholipid synthesis. Here, we examined the PAP-mediated regulation of CHO1-encoded phosphatidylserine synthase (PSS), which catalyzes the committed step for the synthesis of major phospholipids via the CDP-diacylglycerol pathway. The lack of PAP in the pah1Δ mutant highly elevated PSS activity, exhibiting a growth-dependent up-regulation from the exponential to the stationary phase of growth. Immunoblot analysis showed that the elevation of PSS activity results from an increase in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the CHO1 promoter indicated that Cho1 expression in the pah1Δ mutant is induced through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. The abrogation of Cho1 induction and PSS activity by a CHO1 UASINO mutation suppressed pah1Δ effects on lipid synthesis, nuclear/endoplasmic reticulum membrane morphology, and lipid droplet formation, but not on growth at elevated temperature. Loss of the DGK1-encoded diacylglycerol kinase, which converts diacylglycerol to phosphatidate, partially suppressed the pah1Δ-mediated induction of Cho1 and PSS activity. Collectively, these data showed that PAP activity controls the expression of PSS for membrane phospholipid synthesis. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Evolution of the apomixis transmitting chromosome in Pennisetum

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    Yamada-Akiyama Hitomi

    2011-10-01

    Full Text Available Abstract Background Apomixis is an intriguing trait in plants that results in maternal clones through seed reproduction. Apomixis is an elusive, but potentially revolutionary, trait for plant breeding and hybrid seed production. Recent studies arguing that apomicts are not evolutionary dead ends have generated further interest in the evolution of asexual flowering plants. Results In the present study, we investigate karyotypic variation in a single chromosome responsible for transmitting apomixis, the Apospory-Specific Genomic Region carrier chromosome, in relation to species phylogeny in the genera Pennisetum and Cenchrus. A 1 kb region from the 3' end of the ndhF gene and a 900 bp region from trnL-F were sequenced from 12 apomictic and eight sexual species in the genus Pennisetum and allied genus Cenchrus. An 800 bp region from the Apospory-Specific Genomic Region also was sequenced from the 12 apomicts. Molecular cytological analysis was conducted in sixteen Pennisetum and two Cenchrus species. Our results indicate that the Apospory-Specific Genomic Region is shared by all apomictic species while it is absent from all sexual species or cytotypes. Contrary to our previous observations in Pennisetum squamulatum and Cenchrus ciliaris, retrotransposon sequences of the Opie-2-like family were not closely associated with the Apospory-Specific Genomic Region in all apomictic species, suggesting that they may have been accumulated after the Apospory-Specific Genomic Region originated. Conclusions Given that phylogenetic analysis merged Cenchrus and newly investigated Pennisetum species into a single clade containing a terminal cluster of Cenchrus apomicts, the presumed monophyletic origin of Cenchrus is supported. The Apospory-Specific Genomic Region likely preceded speciation in Cenchrus and its lateral transfer through hybridization and subsequent chromosome repatterning may have contributed to further speciation in the two genera.

  20. Comparison of Homogeneous and Heterogeneous CFD Fuel Models for Phase I of the IAEA CRP on HTR Uncertainties Benchmark

    Energy Technology Data Exchange (ETDEWEB)

    Gerhard Strydom; Su-Jong Yoon

    2014-04-01

    Computational Fluid Dynamics (CFD) evaluation of homogeneous and heterogeneous fuel models was performed as part of the Phase I calculations of the International Atomic Energy Agency (IAEA) Coordinate Research Program (CRP) on High Temperature Reactor (HTR) Uncertainties in Modeling (UAM). This study was focused on the nominal localized stand-alone fuel thermal response, as defined in Ex. I-3 and I-4 of the HTR UAM. The aim of the stand-alone thermal unit-cell simulation is to isolate the effect of material and boundary input uncertainties on a very simplified problem, before propagation of these uncertainties are performed in subsequent coupled neutronics/thermal fluids phases on the benchmark. In many of the previous studies for high temperature gas cooled reactors, the volume-averaged homogeneous mixture model of a single fuel compact has been applied. In the homogeneous model, the Tristructural Isotropic (TRISO) fuel particles in the fuel compact were not modeled directly and an effective thermal conductivity was employed for the thermo-physical properties of the fuel compact. On the contrary, in the heterogeneous model, the uranium carbide (UCO), inner and outer pyrolytic carbon (IPyC/OPyC) and silicon carbide (SiC) layers of the TRISO fuel particles are explicitly modeled. The fuel compact is modeled as a heterogeneous mixture of TRISO fuel kernels embedded in H-451 matrix graphite. In this study, a steady-state and transient CFD simulations were performed with both homogeneous and heterogeneous models to compare the thermal characteristics. The nominal values of the input parameters are used for this CFD analysis. In a future study, the effects of input uncertainties in the material properties and boundary parameters will be investigated and reported.

  1. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

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    Robyn D Moir

    2012-08-01

    Full Text Available The ability to store nutrients in lipid droplets (LDs is an ancient function that provides the primary source of metabolic energy during periods of nutrient insufficiency and between meals. The Fat storage-Inducing Transmembrane (FIT proteins are conserved ER-resident proteins that facilitate fat storage by partitioning energy-rich triglycerides into LDs. FIT2, the ancient ortholog of the FIT gene family first identified in mammals has two homologs in Saccharomyces cerevisiae (SCS3 and YFT2 and other fungi of the Saccharomycotina lineage. Despite the coevolution of these genes for more than 170 million years and their divergence from higher eukaryotes, SCS3, YFT2, and the human FIT2 gene retain some common functions: expression of the yeast genes in a human embryonic kidney cell line promotes LD formation, and expression of human FIT2 in yeast rescues the inositol auxotrophy and chemical and genetic phenotypes of strains lacking SCS3. To better understand the function of SCS3 and YFT2, we investigated the chemical sensitivities of strains deleted for either or both genes and identified synthetic genetic interactions against the viable yeast gene-deletion collection. We show that SCS3 and YFT2 have shared and unique functions that connect major biosynthetic processes critical for cell growth. These include lipid metabolism, vesicular trafficking, transcription of phospholipid biosynthetic genes, and protein synthesis. The genetic data indicate that optimal strain fitness requires a balance between phospholipid synthesis and protein synthesis and that deletion of SCS3 and YFT2 impacts a regulatory mechanism that coordinates these processes. Part of this mechanism involves a role for SCS3 in communicating changes in the ER (e.g. due to low inositol to Opi1-regulated transcription of phospholipid biosynthetic genes. We conclude that SCS3 and YFT2 are required for normal ER membrane biosynthesis in response to perturbations in lipid metabolism and ER

  2. "Hot Issue" no Mercado de IPO e suas Consequências para as Empresas Emitentes e Investidores: o Mercado do Reino Unido em 2000

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    João Batista Amorim Toniato

    2007-01-01

    Full Text Available Os gerentes fazem uso do fato de que as ofertas públicas iniciais (OPIs ou IPOs - Initial Public Offerings são eventos discricionários para selecionar a hora de se tornar público, causando ciclos nos mercados de novas emissões. Este trabalho oferece a evidência de cincos estudos clínicos realizados no Mercado IPO em 2000 no Reino Unido, sugerindo que os mercados chamados de "Hot Issue" intensificam duas outras anomalias bem documentadas na área de finanças: o underpricing inicial e o desempenho inferior em longo prazo de emissões novas. Várias explicações comportamentais para o desempenho do retorno dos IPOs estudados são explorados. Nesta investigação o modelo Rock que relaciona o nível de underpricing em curto prazo de IPOs com a assimetria de informação entre investidores parece trabalhar em seu oposto preciso devido ao intenso nível de especulação sobre as emissões. Essa análise comportamental também oferece apoio ao modelo de divergência de opiniões já que o observado desempenho inferior em longo prazo pode ser associado à disponibilidade de informação prévia a respeito da empresa. Gestão de rentabilidade através de acumulações discricionárias anteriores à flutuação também está presente, influenciando o desempenho de empresas onde esta análise pode ser realizada. Os resultados somam-se ao desafio que o comportamento de IPOs apresentam para a hipótese de eficiência do mercado.

  3. Variabilidade da freqüência cardíaca em cães anestesiados com infusão contínua de propofol e sufentanil Heart rate variability in dogs anesthetized with propofol and sufentanil

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    R. Carareto

    2007-04-01

    Full Text Available Foram avaliados os efeitos do propofol associado ao sufentanil sobre o balanço das atividades simpática e parassimpática do coração, investigando-se um possível efeito dose dependente do opióide. Analisou-se a variabilidade da freqüência cardíaca (VFC de 12 cães adultos pré-medicados com maleato de acepromazina e anestesiados com propofol e três doses diferentes de sufentanil, que variou de 0,025 a 0,1µg/kg/min. Registrou-se o eletrocardiograma 15 minutos após a medicação pré-anestésica e 15, 30, 60, 90 e 120 minutos após a indução anestésica. A VFC foi calculada no domínio da freqüência, mediante análise de 10 intervalos RR consecutivos. Houve redução acentuada da freqüência cardíaca, mas a VFC permaneceu relativamente inalterada.The effects of propofol and sufentanil on cardiac sympathetic and parasympathetic balance were studied, in order to evaluate if sufentanil plays a role in this balance. The heart rate variability of 12 adult dogs was assessed, after premedication with acepromazine and anesthetized with propofol and three different doses of sufentanil, ranging from 0.025 to 0.1µg/kg/min. Electrocardiograms were recorded 15 minutes after premedication and 15, 30, 60, 90, and 120 minutes after anesthetic induction. Heart rate variability was calculated in frequency domain through the analysis of 10 consecutive RR intervals. Results showed an absence of important changes in heart rate variability, although a significant decrease in heart rate was observed.

  4. Towards the Lexicographic Description of the Grammatical Behaviour of Japanese Loanwords: A Case Study

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    MOGI, Toshinobu

    2012-10-01

    Full Text Available The present papers offers a case study of a Japanese loanword verb, with the aim of contributing to corpus-based research on Japanese loanwords and of providing a foundation for the compilation of a dictionary of grammatical patterns of loanwords for learners of Japanese as a foreign language. The case study presents an analysis of actual usage of loanword suru-verbs in the large-scale Balanced Corpus of Contemporary Written Japanese, which is followed by a detailed analysis of all examples of the polysemous verb katto-suru. It is thereby shown how corpora can help in describing loanwords by matching a word’s meaning with its patterns of usage, and how such a description can be useful to learners of Japanese as a foreign language.-----Pričujoči članek predstavlja študijo primera japonskega glagola tujega izvora, z namenom prispevati h korpusno-osnovanim raziskavam japonskih tujk in obenem predlagati osnovne smernice za sestavo slovarja slovničnih vzorcev japonskih tujk za učence japonščine kot tujega jezika. Predstavljena je analiza rabe samostalniških glagolov na -suru v velikem uravnoteženem korpusu sodobne pisne japonščine (BCCWJ, čemur sledi podrobna analiza vseh primerov večpomenskega glagola katto-suru. S tem je prikazano, kako lahko uporaba korpusa pripomore k opisu tujk z vzporejanjem podpomenov in vzorcev rabe posameznih besed ter kako lahko tak opis koristi učencem japonščine kot tujega jezika.

  5. Binding characteristics of sigma2 receptor ligands Características estruturais de ligantes do receptor sigma2

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    Richard A. Glennon

    2005-03-01

    Full Text Available Sigma (sigma receptors, once considered a type of opioid receptor, are now recognized as representing a unique receptive entity and at least two different types of sigma receptors have been identified: sigma1 and sigma2 receptors. Evidence suggests that these receptors might be targeted and exploited for the development of agents potentially useful for the treatment of several central disorders. This review primarily describes some of our efforts to understand those structural features that contribute to sigma2 receptor binding, and some recent work by other investigators is also included. Despite an inability to formulate a unified pharmacophore model for sigma2 binding due to the diversity of structure-types that bind at the receptor, and to the conformational flexibility of these ligands, significant progress has been made toward the development of some very high-affinity agents.Receptores sigma (sigma, considerados como um tipo de receptor opióide, sigma ão hoje considerados como uma entidade receptora singular. Pelo menos dois subtipos desses receptores foram identificados: sigma1e sigma2. Há evidências de que esses receptores devam ser explorados como alvo para o desenvolvimento de agentes potencialmente úteis para o tratamento de várias disfunções centrais. Esta revisão descreve, principalmente, alguns dos nossos esforços para compreender as características estruturais que contribuem para a ligação no receptor sigma2 , e incluem-se alguns trabalhos recentes desenvolvidos por outros pesquisadores. Apesar da incapacidade de formular um modelo de farmacóforo único para ligação no receptor s 2, em razão da diversidade de estruturas que a ele se ligam e da flexibilidade conformacional desses ligantes, houve progresso significativo no desenvolvimento de agentes de alta afinidade.

  6. Detección de benzodiacepinas en sujetos fallecidos por Reacción Aguda a Drogas en Galicia (1997-2011

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    D Miguel-Arias

    2016-01-01

    Full Text Available La muerte por reacción aguda a drogas constituye la complicación más grave del consumo de sustancias y una de las principales causas de mortalidad entre la población drogodependiente. Los análisis toxicológicos llevados a cabo en fallecidos muestran la presencia de múltiples sustancias debido a la extensión del patrón de policonsumo. La combinación más habitual (y más peligrosa, es la de varias sustancias depresoras del sistema nervioso central, en particular la asociación de opiáceos con benzodiacepinas y/o alcohol. Este hecho, junto con la extensión del uso y abuso de estos psicofármacos, con o sin prescripción facultativa, determina que estas sustancias sean detectadas con mucha frecuencia entre los fallecidos por esta causa. Estudiamos todas las muertes por reacción aguda tras consumo de drogas (n=805 en la Comunidad Autónoma de Galicia entre los años 1997- 2011. La mayoría de ellos eran varones (91,2%, solteros (47,7%, con una edad media de 34,3 años y con larga trayectoria de consumo.La presencia de benzodiacepinas fue detectada en el 42,4 % de todos los fallecidos. A lo largo de los años de estudio se observan diferencias significativas en este porcentaje, pero sin una tendencia clara. La sustancia que se encuentra con más frecuencia es el alprazolam, seguido del nordiazepam, diazepam y lormetazepam.

  7. A COMPARATIVE STUDY ON HYPOTHALAMIC MECHANISMS OF ANALGESIA INDUCED BY FOUR KINDS OF ACUPUNCTURE THERAPIES IN ADJUVANT ARTHRITIS RATS

    Institute of Scientific and Technical Information of China (English)

    FU Yi; LIANG Fan-rong; TAO Qiao-lin

    2005-01-01

    Objective: To compare the mechanisms of analgesia induced by four kinds of acupuncture therapies at the hypothalamic level in adjuvant arthritic rats. Methods: Forty-eight SD rats were randomized into normal, model, electroacupuncture (EA), filiform needle (FN), pricking blood-letting (BL) and point injection (PI) groups, with 8 cases in each. EA (20-100 Hz, 2-4 V and duration of 20 min), FN, BL PI were respectively applied to "Kunlun" (昆仑BL 60). Arthritis model was established by injecting complete Freund's adjuvant (0.1 mL) into the rat's right foot pad. Behavioral reactions, pain threshold (latency of tail flick to heat stimulation) and local swelling severity (foot volume) were detected; the contents of β-endorphin (β-EP) and adrenocorticotropin (ACTH) were assayed with radioimmunoassay; and the expression of pro-opi-omelanocortin (POMC) mRNA in hypothalamus were determined with hybridization method. Results: The pain threshold was significantly enhanced by all the four kinds of acupuncture therapies, and the effects of EA and PI were more obvious (P0.05). The content of β-EP in the hypothalamus was obviously elevated by EA and FN (P0.05). The content of ACTH in hypothalamus was considerably elevated by PI (P<0.05), but not by the other three therapies. The expression of POMCmRNA in hypothalamus was significantly strengthened by EA and FN (P<0.01), but not by the other two therapies. Conclusion: EA, filiform needle, blood-letting and point-injection all can produce analgesic effect in adjuvant arthritis rats, the effect of EA and filiform needle may be related to their resultant increase of hypothalamic β-EP, and that of point-injection related to the increase of hypothalamic ACTH level.

  8. Upitne rečenice u današnjem rovinjsko istroromanskom govoru

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    Pavao Tekavčić

    1987-12-01

    Full Text Available Ovaj je rad dio studija današnjega istroromanskog dijalekta grada Rovinja, idioma na kojem pišu suvremeni rovinjski pisci Giusto Curto, Giovanni Santin, Giovanni i Antonio Pellizzer, u antologiji nagradenih radova pod naslovom lstria Nobilissima. Zbog obimnosti materijala studiraju se samo nezavisne upitne rečenice, na korpusu od 747 primjera. Upitne su rečenice važan dio sintakse rečenice i perioda, odnosno iskaza i teksta, a uz svoju osnovnu funkciju (traženje informacija mogu imati i druge, sekundarne funkcije prvenstveno pragmatičke prirode. Nakon pregleda temeljnih kategorija potrebnih za opis i analizu upitnih rečenica analizira se izbor od 91 primjera (koneksionalne, nuklearne, alternativne, eliptične rečenice, rečenice pitanja »na kvadrat« i »jeke i nadovezivanja«. rečenice stopljene iz dvaju različitih tipova i, na kraju, fosilizirane upitne rečenice k oje u današnjem jeziku funkcioniraju kao pragmatičke formule za izražavanje rezignacije, negacije, strogosti, najave važnih dijelova iskaza itd.. U suvremenoj su rovinjskoj prozi zastupani svi glavni tipovi upitnih rečenica, što s jedne strane dokazuje njihovu važnost u spontanom govoru, a s druge strane svjedoči i o umješnosti autorii koji, pišući na rovinjskom, umiju donijeti na pozornicu (ili pred čitaoca živi i spontani govor svoga kraja.

  9. The clinical value of two surgical methods in the treatment of uterine scar defect%两种手术方式在子宫瘢痕缺损治疗中的价值

    Institute of Scientific and Technical Information of China (English)

    梁凤霞; 黄玉玲

    2014-01-01

    Objective The clinical value Of hysterOscOPic electric resectiOn and vaginal rePair Of uterine scar in the treatment Of uterine scar defect were analyzed. Methods 36 cases with uterine scar defect in Dalang Hospital of Dongguan City frOm January 2009 tO February 2013 were cOllected,all cases were diagnOsed by B - ultrasOund and hysterOscOPy,the medical theraPy was invalid. All cases were given hysterOscOPic electric resectiOn Or aginal rePair Of uterine scar accOrding tO fertility requirement,with 16 cases in the hysterOscOPe grOuP and 20 cases in the vaginal surgery grOuP,Patients were fOllOw - uP 6 mOnths tO 1 year POst - OPeratiOn. Results In the hysterOscOPy grOuP 5 cases were healed,6 cases were with an imPrOvement,5 cases were with nO effect,the tOtal effective rate was 68. 75% ;In the vaginal surgery grOuP,13 cases were healed,7 cases were with an imPrOvement,the tOtal effective rate was 100% . The length Of hOsPital stay,hOsPitalizatiOn exPenses in vaginal surgery grOuP were significantly increased than that in hysterOscOPy grOuP(P < 0. 05). Conclusion The vaginal rePair Of uterine scar in the treatment Of uterine scar defect is minimally invasive with effectiveness. FOr thOse Patients with nO fertility requirement Or have ecOnOmic difficulties can chOOse hysterOscOPic electric resectiOn,which alsO have gOOd effect tO alleviate symPtOms.%目的:采用宫腔镜电切或阴式子宫瘢痕修补术治疗剖宫产术后子宫瘢痕缺损,分析两种手术方式的临床应用价值。方法收集东莞市大朗医院2009年1月至2013年2月通过阴道 B 超及宫腔镜确诊子宫瘢痕缺损并经药物治疗无效的病例36例,按有无生育要求行宫腔镜电切或经阴道行子宫切口瘢痕缺损切除重新缝合,其中宫腔镜组16例,阴式手术组20例,术后跟踪随访6个月至1年。结果宫腔镜组治愈5例,好转6例,无效5例,总有效率68.75%;阴式手术组治愈13例,好转7例,总有效率100%。住

  10. Drogadicción, Fármaco-Dependencia o Drogadicción

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    Mario Camacho Pinto

    1994-09-01

    13adrenérgicos y a los histamínicos. Actualmente se admite la existencia de seis grupos de estos receptores opioides en el cerebro, de los cuales uno regula la conducta emocional, otro la percepción del dolor y la analgesia, otro las alucinaciones y la disforia, etc. Aparece claramente definido que el sistema nervioso central y también el periférico, las a encefalinas actúan como neurotransmisores, mientras que las 13endorfinas actúan como neuro-hormonas.

    Se admiten 15 roles a los péptidos opioides endógenos, entre los cuales es conducente citar: percepción del dolor, drogadicción opiácea, liberación de hormonas, memoria, conducta sexual e integración y respuesta al estrés.

    El estudio de los receptores opiáceos realizado por Hiller y asociados, ha demostrado que la más alta densidad del “binding” o ligazón ocurre en el sistema límbico, en las áreas asociadas con la percepción del dolor y/o su modulación (tálamo, sustancia gris periacueductal, cuerno gris dorsal de la médula espinal y también en el nervio vago, la médula suprarrenal, la placentay el tracto gastrointestinal.

    El papel de los receptores opiáceos en el desarrollo de la tolerancia, adicción o abstinencia está en estudio; el conocimiento actual sugiere que su fisiopatología puede estar más relacionada con los efectos posreceptor, a ejemplo de la alteración del ciclo adenosina monofosfato.

    Agentes Neurotóxicos
    Está médicamente demostrado que las drogas estimulantes o euforizantes pueden dar intoxicación, con daño temporal o permanente, por varios mecanismos tales como la inactivación de enzimas y coenzima~ esenciales para los mecanismos de oxidación; alteración de vasos nutrientes; manifestaciones alérgicas o inmunológicas; efectos nocivos sobre los neurotransmisores; alteración en el balance ácido-base o en las concentracions iónicas. Algunos casos llegan a simular entidades neurológicas o a acentuar una pre

  11. Relación del efecto analgésico de fentanilo agudo con la regulación a la alta de los receptores 5-HT1A cerebrales en la rata Relationship between the analgesic effect of acute fentanyl and upregulation of brain 5-HT1A receptors in the rat

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    I. Bellido

    2004-07-01

    Full Text Available Los agonistas 5-HT1A presentan efecto analgésico. El efecto analgésico de los agonistas µ puede ser bloqueado por antagonistas selectivos 5-HT1A. Para determinar el mecanismo de producción del sinergismo observado entre los receptores µ y serotoninérgico 5-HT1A en relación con su efecto antinociceptivo, determinamos el efecto analgésico de fentanilo tras estímulo nociceptivo de tipo térmico y mecánico en la rata relacionándolo con la afinidad y la densidad máxima de los receptores 5-HT1A de trece áreas cerebrales mediante técnicas de autorradiografía. Fentanilo presentó un efecto analgésico dosis y tiempo dependiente ante los dos estímulos nociceptivos. Paralelamente a la aparición del efecto analgésico, fentanilo originó una regulación a la alta de los receptores 5-HT1A al incrementar de forma dosis-dependiente su densidad sin modificar su afinidad. La dosis mayor de fentanilo (12,8 µg.kg-1 originó un incremento de la densidad de los receptores 5-HT1A estadísticamente significativo y que se correlacionó de forma positiva con su efecto analgésico en las áreas terminales corticales fronto-parietal externa (+64%, interna (+69% y piriforme (+113%, las regiones del hipocampo CA1 (+111% y DGm (+60%, los núcleos amigdalinos PMCo (+101% y AHiAL (+91% y el hipotálamo (+127%. El efecto analgésico de fentanilo en tratamiento agudo se explicaría, al menos, por dos mecanismos. Su capacidad de estimular la neurotransmisión opiácea actuando directamente sobre los receptores opiáceos µ. Y porque, al incrementar los niveles de 5-HT a nivel central y al regular a la alta los receptores 5-HT1A de zonas cerebrales terminales, se facilitaría la estimulación de estos receptores. Dado que los receptores 5-HT1A postsinápticos actúan como heteroreceptores de efecto inhibidor sobre neuronas no serotoninérgicas originando una hiperpolarización neuronal, fentanilo, al facilitar el estímulo de estos receptores originaría una

  12. 基于经验模态分解样本熵的肌电信号识别%EMG SignaI Recognition Based on EMD SampIe Entropy

    Institute of Scientific and Technical Information of China (English)

    席旭刚; 朱海港; 罗志增; 张启忠

    2014-01-01

    AccOrding tO the chaOtic and nOnIinear characteristics Of surface eIectrOmyOgraphy( sEMG ),a fast and efficient hands mOvement sEMG pattern recOgnitiOn methOd fOr reaI-time cOntrOI Of myOeIectric prOsthetic hand is designed. A muIti-mOdeIing pattern recOgnitiOn methOd Of sEMG features based On the empiricaI mOde decOmpOsitiOn( EMD ) sampIe entrOpy and cIustering anaIysis is prOpOsed. First,it decOmpOses the sEMG signaI intO a set Of intrinsic mOde functiOns ( IMF),then cOmbines sOme Of the IMF which cOntains the usefuI infOrmatiOn accOrding tO frequency effectiveness,and caIcuIates the sampIe entrOpy Of the cOmbinatiOn. The sampIe entrOpy Of twO sEMG Of the extensOr carpi uInaris and fIexOr carpi uInaris cOnstitute the feature vectOr,the cIustering cIassifier which based On principaI axis cIustering arithmetic is appIied tO cIassify the fOur hand mOvements. The resuIt shOws that fOur mOvements( hand extensiOn,hand grasps,wrist spreads and wrist bends ) are successfuIIy identified. The average recOgnitiOn rate is 93%. The methOd achieved high recOgnitiOn rate,anti-interference abiIity and Iess cOmputatiOn,that is suitabIe fOr the cOntrOI Of the myOeIectric prOsthetic hand.%针对表面肌电信号非线性、噪声强等特点,设计一种快速有效的表面肌电信号手部多运动模式识别方法,用于肌电假手的实时控制。提出了一种基于经验模态分解样本熵和聚类分析的表面肌电信号多运动模式识别方法。该方法对动作持续阶段的信号首先进行经验模态分解,将其分解为多个平稳的固有模态函数( IMF),再依据频率有效度选取若干个包含肌电信号有效信息的IMF分量求和后,计算其样本熵。以尺侧腕伸肌和尺侧腕屈肌两路肌电信号对应的EMD样本熵作为特征向量,设计了主轴核聚类算法的聚类分类器进行模式识别。成功识别了展拳、握拳、腕上翻和腕下翻4种动作,平均识别率达到93%。该方法取

  13. Manejo de la analgesia postoperatoria en las primeras 24 horas en un Hospital de segundo nivel: Estudio observacional Postoperative analgesia treatment during the first 24 hours in a second level hospital.

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    D. L. Fernández

    2006-01-01

    Full Text Available Objetivo: Evaluar el cumplimiento y eficacia de la medicación analgésica no protocolizada y utilizada en un hospital de segundo nivel en las 24 h posteriores a cirugía, donde la intensidad del dolor está catalogada como moderada severa. Método: Estudio prospectivo y observacional. Se incluyeron 119 pacientes mayores de 18 años, intervenidos de cirugía traumatológica: prótesis total de cadera, rodilla, artrodesis vertebral, cirugía de hombro y laparotomías. Ante la falta de protocolos, la medicación analgésica postoperatoria de base y de rescate fue prescrita según criterio del anestesiólogo responsable. La administración de cloruro mórfico y el empleo de los dispositivos de administración: catéteres peridurales, PCA (analgesia controlada por el paciente quedaron restringidos a la unidad de recuperación anestésica (URPA y al área crítica. En planta de hospitalización los opiáceos prescritos fueron la meperidina por vía intramuscular y el tramadol endovenoso. Los opiáceos siempre se asociaron a analgésicos parenterales como metamizol, diclofenaco o paracetamol Se valoró la intensidad del dolor (VAS 0-100 mm y escala verbal EV 1-4 24 h después de la cirugía (24 y se registró la máxima intensidad de dolor percibida en el primer día de postoperatorio (Max. Se consideró el porcentaje de pacientes con dolor no controlado (DNC: VAS >30 y EV >2 para los momentos 24 y Max. Se consignaron las dosis de fármacos analgésicos de base y rescate, prescritos y consumidos. Para cada analgésico prescrito como base, se calculó la diferencia porcentual entre la dosis media prescrita y la dosis media consumida, indicador que se denominó grado de cumplimiento (GC. Resultados: Intensidad de dolor 24: VAS 27.8 ± 22.6, EV 2; porcentaje de pacientes con DNC según VAS /EV: 36.1/ 42.8%, respectivamente. Max: VAS 58.4 ± 28.9, EV 4; DNC según VAS/EV : 79.8 / 82.3 %, respectivamente. Prescripción de opiáceos (Nº pacientes, X ± DE

  14. Analgesia pós-operatória para procedimentos cirúrgicos ortopédicos de quadril e fêmur: comparação entre bloqueio do compartimento do psoas e bloqueio perivascular inguinal Analgesia postoperatoria para procedimientos quirúrgicos ortopédicos de cadera y fémur: comparación entre bloqueo del compartimiento del psoas y bloqueo perivascular inguinal Postoperative analgesia for orthopedic surgeries of the hip and femur: a comparison between psoas compartment and inguinal paravascular blocks

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Imbelloni

    2006-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Este estudo avaliou a eficácia da injeção única de bupivacaína a 0,25% no compartimento do psoas ou perivascular inguinal por meio do estimulador de nervos periféricos para analgesia pós-operatória em pacientes submetidos a intervenções cirúrgicas ortopédicas. MÉTODO: Cem pacientes receberam bloqueio do plexo lombar através do compartimento do psoas e foram comparados com 100 pacientes que receberam bloqueio do plexo lombar via perivascular inguinal, identificados pelo estimulador de nervos periféricos com a injeção de 40 mL bupivacaína a 0,25% sem epinefrina. A analgesia nos nervos ilioinguinal, genitofemoral, cutâneo femoral lateral, femoral e obturatório foi avaliada 4, 8, 12, 16, 20 e 24 horas após o final da intervenção cirúrgica. A intensidade da dor foi também avaliada no mesmo período. A quantidade de opióides administrada no pós-operatório foi anotada. Em cinco pacientes de cada grupo, estudo radiográfico com contraste não-iônico foi realizado para avaliar a dispersão da solução anestésica. RESULTADOS: Os nervos ilioinguinal, genitofemoral, cutâneo femoral lateral, femoral e obturatório foram bloqueados em 92% dos pacientes no compartimento do psoas versus 62% no bloqueio perivascular inguinal. O bloqueio do plexo lombar reduziu a necessidade de opióides e 42% dos pacientes submetidos ao bloqueio do compartimento do psoas e 36% dos pacientes no bloqueio inguinal não necessitaram de analgésico adicional no pós-operatório. A duração da analgesia foi em torno de 21 horas com bloqueio do compartimento do psoas e 15 horas com bloqueio perivascular inguinal. CONCLUSÕES: O bloqueio do compartimento do psoas e perivascular inguinal é uma excelente técnica para analgesia pós-operatória em intervenções cirúrgicas ortopédicas reduzindo a necessidade de opióides. Este estudo mostrou que a injeção no compartimento do psoas foi mais fácil e mais efetiva no bloqueio

  15. Drogas emergentes (II: el pharming

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    G. Burillo-Putze

    2013-04-01

    Full Text Available El uso por la población joven de fármacos con y sin receta médica con fines recreativos, ha tenido escasa atención por los médicos. En USA, uno de cada cinco adolescentes han usado fármacos con finalidad recreativa, y en el servicio de Urgencias, las consultas por abuso de fármacos han superado a las de drogas ilegales. Aunque es España existen pocos datos, este consumo se sitúa, según las encuestas, entre el 3,1 y el 8,6%. Los fármacos más utilizados son el dextrometorfán y el metilfenidato. El primero, de venta sin receta, presenta una sintomatología variable, dosis y acción metabólica dependiente, el cual varía desde la euforia a las alucinaciones. El metilfenidato se utiliza como estimulante sustituto de la cocaína, tanto por vía oral como nasal e intravenosa, siendo uno de los fármacos con más desvío hacia el mercado ilícito a nivel mundial. Otras sustancias como el modafinilo y el propofol presentan un uso no médico en principio de escasa incidencia, pero con un potencial de abuso a tener en cuenta, sobre todo en el ámbito sanitario. Finalmente, opiáceos como el fentanilo, la oxicodona y la buprenorfina, de reciente generalización en el arsenal terapéutico de muchas especialidades médicas y con nuevas presentaciones farmacéuticas, están produciendo fenómenos de abuso, dependencia y comercio ilícito. Las demandas de tratamiento de desintoxicación, la mezcla con sustancias ilegales y los casos de muerte, alertan sobre el abuso de estos fármacos.

  16. Sufentanil intratecal para revascularização do miocárdio

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    Caetano Nigro Neto

    2014-04-01

    Full Text Available Contexto: pacientes de cirurgia cardíaca submetidos a revascularização do miocárdio com circulação extracorpórea. Objetivo: avaliar o efeito hemodinâmico da adição de sufentanil intratecal para anestesia geral. Desenho: estudo prospectivo, randômico e aberto, após aprovação do Comitê de Ética em Pesquisa. Cenário: estudo monocêntrico feito no Instituto Dante Pazzanese de Cardiologia, São Paulo, Brasil. Pacientes: foram submetidos à revascularização eletiva 40 pacientes de ambos os sexos que assinaram o termo de consentimento informado. Critérios de exclusão: doença renal crônica, procedimentos de emergência, reoperações, contraindicação para raquianestesia, fração de ejeção do ventrículo esquerdo inferior a 40%, índice de massa corporal acima de 32 kg/m2 e uso de nitroglicerina. Intervenções: os pacientes foram randomizados para receber (ou não 1μg/kg de sufentanil intratecal. Anestesia foi induzida e mantida com infusão contínua de sevoflurano e remifentanil. Principais medidas de desfecho: variáveis hemodinâmicas, níveis sanguíneos de troponina I cardíaca, peptídeo natriurético do tipo B, interleucina-6 e fator de necrose tumoral alfa durante e após a cirurgia. Resultados: os pacientes do grupo sufentanil precisaram de menos suporte inotrópico com dopamina, comparados aos do grupo controle (9,5% vs 58%, p = 0,001, e menos aumentos de doses de remifentanil (62% vs 100%, p = 0,004. Os dados hemodinâmicos em oito intervalos de tempo diferentes e os dados bioquímicos não apresentaram diferenças entre os grupos. Conclusões: os pacientes que receberam sufentanil intratecal apresentaram uma estabilidade hemodinâmica maior, como sugerido pelo suporte inotrópico reduzido, e menos ajustes nas doses intravenosas de opiáceos.

  17. Uso de medicações por via subaracnóidea no tratamento da dor crônica

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    Rocha Anita Perpétua Carvalho

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A dor crônica é um desafio para a Medicina atual. Novos métodos e medicamentos têm sido propostos com o intuito de controlar os sintomas álgicos. A via de administração subaracnóidea tem se mostrado como uma alternativa viável e segura, embora necessite continuamente ser objeto de estudo de muitos pesquisadores. O objetivo deste trabalho é fazer uma revisão dos medicamentos disponíveis no arsenal terapêutico já consagrados pelo uso e os que se mostram promissores na atualidade para a prática clínica diária. CONTEÚDO: Nesta revisão são avaliados vários fármacos que apresentam ação analgésica quando utilizada via neuroeixo. Opióides, anestésicos locais, agonistas alfa2-adrenérgicos, antagonistas dos aminoácidos excitatórios e inibitórios, acetilcolina, inibidores da acetilcolinesterase, bloqueadores dos canais de cálcio, adenosina, serotonina, antidepressivos tricíclicos e inibidores da síntese de prostaglandinas são analisados no que concerne aos seus efeitos farmacológicos, incluindo os indesejáveis. CONCLUSÕES: Muitos avanços foram registrados no controle dos sintomas álgicos após a utilização das substâncias citadas por via raquidiana, onde certamente algumas serão aproveitadas e enriquecerão o arsenal terapêutico e outras relegadas temporária ou definitivamente. Entretanto, ainda serão necessários muitos estudos clínicos e experimentais para que estes conhecimentos possam ser incorporados e utilizados com segurança pelos profissionais que lidam com o tratamento da dor crônica.

  18. Impacto do exercício na dor crônica

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    Marlon Alves Subtil da Oliveira

    2014-06-01

    Full Text Available INTRODUÇÃO: A dor é uma experiência subjetiva, que pode resultar de características teciduais, mas que também abrange fatores de várias ordens, incluindo os emocionais, culturais e individuais. A dor crônica é persistente ou recorrente, por mais de 3 meses, de causa desconhecida e não está necessariamente associada a uma lesão no organismo. Os gastos associados a essa condição de saúde estimulam o sistema a investigar intervenções eficazes para o tratamento das dores em geral. O fenômeno da analgesia induzida pelo exercício é sobretudo observado em atletas e os mecanismos envolvidos ainda são desconhecidos, embora haja tendência a aceitar a ação do sistema opióide endógeno. OBJETIVO: Investigar o efeito de um programa de exercícios físicos sobre a dor crônica inespecífica. MÉTODO: A amostra foi constituída por 29 indivíduos que aderiram a um programa de exercícios domiciliares. Sendo aplicado o Questionário Internacional de Atividade Física (IPAQ que permite estimar o tempo semanal gasto em atividades físicas de intensidade leve, moderada e vigorosa e a Escala Visual Analógica (EVA que foi utilizada para avaliar a intensidade da dor. A análise estatística foi realizada de forma descritiva e inferencial. CONCLUSÃO: A aplicação de programas multidisciplinares, predominando a prescrição de exercícios aeróbicos, de fortalecimento e alongamentos, em um protocolo de exercícios domiciliares apresentou melhora efetiva no limiar de dor em paciente com dor crônica inespecífica.

  19. Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain Possível efeito analgésico da vigabatrina na dor neuropática crônica experimental animal

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    NILZA D. ALVES

    1999-12-01

    Full Text Available Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model. For testing pain symptoms, spontaneous (scratching and evoked behaviors to noxious (46o C and non-noxious (40o C thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA on experimental neuropathic pain, as shown by the significant (pO uso de anticonvulsivantes no tratamento de neuralgias despertou um interesse em testar novas drogas anticonvulsivantes, e dentre essas a vigabatrina por possuir mecanismo de ação gabaérgico. Para isso, foram usados 41 ratos Wistar e em 25 deles induziu-se neuropatia ciática constritiva (modelo de Bennett & Xie. Para testar sintomas de dor, foram quantificados comportamentos espontâneos (coçar-se e evocados, por meio de estímulos térmicos nocivos (46oC e não-nocivos (40oC. Além disso, realizou-se estudo comparativo da vigabatrina com outros anticonvulsivantes analgésicos. Os resultados mostraram um possível efeito analgésico, dose-dependente, de vigabatrina (gama-vinil-GABA em dor neuropática experimental. Isso foi evidenciado pela diminuição significativa (p<0,05 do comportamento de coçar-se e pelo aumento significativo (p<0,05 da latência de retirada da pata posterior direita a estímulos térmicos nocivos. Isso foi corroborado por achados semelhantes em experimentos com anticonvulsivantes (carbamazepina, fenitoína e ácido valpróico analgésicos. Esse possível efeito analgésico da vigabatrina (ainda não descrito na literatura não é mediado pelo sistema opióide.

  20. Uso não-médico de medicamentos psicoativos entre escolares do ensino fundamental e médio no Sul do Brasil Non-medical use of psychoactive medicines among elementary and high school students in Southern Brazil

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    Tatiane da Silva Dal Pizzol

    2006-01-01

    Full Text Available O objetivo do presente estudo é investigar a prevalência de uso não-médico de medicamentos entre escolares da rede de ensino público e privado de Passo Fundo, Rio Grande do Sul, Brasil, e sua distribuição em relação a fatores sócio-demográficos. Por meio de um delineamento transversal, foi aplicado um questionário de autopreenchimento a 5.057 estudantes a partir da quinta série do ensino fundamental até o terceiro ano do ensino médio. O questionário continha perguntas sobre o uso, sem receita médica, de anfetamínicos, ansiolíticos, barbitúricos, anticolinérgicos, opiáceos, orexígenos e anabolizantes. Da amostra, 7,7% consumiram ansiolíticos alguma vez na vida, 6,4% consumiram anfetamínicos, 2,2%, anabolizantes, e 1,1%, barbitúricos. Estudantes do sexo feminino apresentaram maior consumo de ansiolíticos e anfetamínicos, enquanto que o consumo de anabolizantes foi maior no sexo masculino. O padrão de consumo de medicamentos psicoativos é semelhante ao observado em adultos, sugerindo a necessidade de inclusão de crianças e adolescentes nas campanhas educativas para prevenção do uso indevido de medicamentos.The objective of this study is to assess the prevalence of and risk factors for the non-medical use of psychoactive medicines among students at public and private schools of Passo Fundo, Southern Brazil. A cross-sectional study was carried out using a questionnaire administered to 5,057 students from the 5th grade of elementary school to the 3rd year of high school. The questionnaire contained questions about the use of amphetamines, tranquilizers, barbiturates, anticholinergics, opioids, appetite stimulants, and anabolic steroids. Of the sample total, 7.7% had consumed tranquilizers sometime during their lives, 6.4% had used amphetamines, 2.2% had used anabolic steroids, and 1.1% had used barbiturates. Female students reported significantly greater consumption of tranquilizers and amphetamines, while anabolic

  1. Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy.

    Science.gov (United States)

    Rice, A S C; Farquhar-Smith, W P; Nagy, I

    2002-01-01

    , endogenous and exogenous, in analgesia have been recently reviewed elsewhere (Rice, Curr Opi Invest Drugs 2001; 2: 399-414; Pertwee, Prog Neurobil 2001; 63: 569-611; Rice, Mackie, In: Evers A. S, ed. Anesthetic Pharmacology: Physiologic Principles and Clinical Practice. St. Louis: Harcourt Health Sciences, 2002). Since a major goal in the development of cannabinoid-based analgesics is to divorce the antinociceptive effects from the psychotrophic effects, the discussion will focus on the antinociceptive effects produced at the spinal cord and/or peripheral level as these areas are the most attractive targets in this regard. A mechanistic discussion of the "framework" for analgesia will be followed by a description of studies examining the role of endocannabinoids in relieving pain; since the elucidation of these effects was undertaken using synthetic cannabinoids, reference will also be made to such studies, in the context of endocannabinoids.

  2. Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil Estudo comparativo entre anestesia venosa total alvo-controlada e por infusão contínua em cães pré-tratados com levomepromazina e tratados com propofol e remifentanila

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    Eduardo Hatschbach

    2008-02-01

    ínua e boa hipnose. CONCLUSÕES: As doses de propofol utilizadas em ambas as técnicas, após o pré-tratamento de levomepromazina e associadas ao opióide, foram eficazes para a realização cirúrgica. A técnica de anestesia alvo controlada obteve um menor consumo de anestésico (propofol com períodos mais rápidos de recuperação.

  3. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel.

    Science.gov (United States)

    Teo, Wei Suong; Ling, Hua; Yu, Ai-Qun; Chang, Matthew Wook

    2015-01-01

    Biodiesel is a mixture of fatty acid short-chain alkyl esters of different fatty acid carbon chain lengths. However, while fatty acid methyl or ethyl esters are useful biodiesel produced commercially, fatty acid esters with branched-chain alcohol moieties have superior fuel properties. Crucially, this includes improved cold flow characteristics, as one of the major problems associated with biodiesel use is poor low-temperature flow properties. Hence, microbial production as a renewable, nontoxic and scalable method to produce fatty acid esters with branched-chain alcohol moieties from biomass is critical. We engineered Saccharomyces cerevisiae to produce fatty acid short- and branched-chain alkyl esters, including ethyl, isobutyl, isoamyl and active amyl esters using endogenously synthesized fatty acids and alcohols. Two wax ester synthase genes (ws2 and Maqu_0168 from Marinobacter sp.) were cloned and expressed. Both enzymes were found to catalyze the formation of fatty acid esters, with different alcohol preferences. To boost the ability of S. cerevisiae to produce the aforementioned esters, negative regulators of the INO1 gene in phospholipid metabolism, Rpd3 and Opi1, were deleted to increase flux towards fatty acyl-CoAs. In addition, five isobutanol pathway enzymes (Ilv2, Ilv5, Ilv3, Aro10, and Adh7) targeted into the mitochondria were overexpressed to enhance production of alcohol precursors. By combining these engineering strategies with high-cell-density fermentation, over 230 mg/L fatty acid short- and branched-chain alkyl esters were produced, which is the highest titer reported in yeast to date. In this work, we engineered the metabolism of S. cerevisiae to produce biodiesels in the form of fatty acid short- and branched-chain alkyl esters, including ethyl, isobutyl, isoamyl and active amyl esters. To our knowledge, this is the first report of the production of fatty acid isobutyl and active amyl esters in S. cerevisiae. Our findings will be useful for

  4. Diario de una vida que no pudo ser: Estudio fenomenológico sobre la drogodependencia Diary of a life that could not be: A phenomenological stugy of drug addiciton

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    Juan M. Leyva-Moral

    2007-09-01

    Full Text Available Justificación: El profesional de enfermería juega un papel crucial en la atención a las personas drogodependientes ya que son la puerta de entrada al conocimiento de las familias, del barrio y de los jóvenes. Conocer dicha realidad puede resultar útil para diseñar estrategias de promoción de la salud así como campañas de prevención. Objetivo: El objetivo de este estudio es conocer el significado que la persona drogodependiente atribuye a su drogadicción. Diseño: Estudio cualitativo con un enfoque fenomenológico. Metodología: Carmen es una mujer de 41 años, adicta a opiáceos desde los 17 años, ingresada en la Unidad de Patología Dual de un centro neuropsiquiátrico en Barcelona, durante el mes de septiembre de 2006. Para la recogida de datos se utilizó un diario semi-estructurado. Resultados: Se describe la drogadicción como algo negativo, responsable de sentimientos de tristeza, fracaso, destrucción y un gran deterioro emocional secundario a los sentimientos de culpabilidad. La participante describe este fenómeno en tres fases: uso-abuso-adicción. Conclusión: El diario elaborado por Carmen permite conocer el significado de la drogadicción y del internamiento para su deshabituación.Justification: Nurses play a crutial role in taking care of people with drug-abuse problems since they know the reality of families, the neighbourhood and the youths. Knowing this reality can be useful to design strategies of health promotion as well as prevention campaigns. Aim: The main aim of this study is to ascertain the meaning that a drug user gives to her situation with substance misuse. Design: Qualitative study based with a phenomenological approach. Methodology: Carmen is a 41 years old woman, addict to opioids since she was 17. Data was collected using a diary while she was admitted in a Dual Pathology Unit in a neuro-psichiatric hospital in Barcelona during September 2006. Results: Drug addiction is drescribed by the participant

  5. Treatment of restless legs syndrome Tratamento da síndrome das pernas inquietas

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    Tiago Spolador

    2006-12-01

    Full Text Available OBJECTIVE: Restless legs syndrome is a neurological disorder characterized by a desire to move limbs, which is usually only present or worsens during rest or at night. The objective of this article was to review the available literature about pharmacological treatment for this disorder. METHOD: A search of recent literature was undertaken on online databases (Medline, Pubmed, Scielo and Lilacs. RESULTS: 502 articles were retrieved, of which 30 were selected. Dopaminergic agents, anticonvulsants, opioids, benzodiazepines, zolpidem, entacapone and ketamine were all effective on the restless legs syndrome treatment. One study showed that iron was not effective. CONCLUSIONS: Based on few double-blind, randomized, controlled trials, it seems that the best options to treat restless legs syndrome patients are gabapentin and L-dopa associated to its sustained release formulation.OBJETIVO: A síndrome das pernas inquietas é um transtorno neurológico caracterizado por um desejo incontrolável de mover os membros, que comumente está somente presente ou piora ao descanso ou à noite. O objetivo do trabalho foi a revisão da literatura disponível sobre o tratamento farmacológico para a síndrome das pernas inquietas. MÉTODO: Pesquisa da literatura recente realizada em bases de dados eletrônicas (Medline, Pubmed, Scielo e Lilacs. RESULTADOS: Quinhentos e dois artigos foram encontrados, dos quais 30 foram selecionados. Os agentes dopaminérgicos, os anticonvulsantes, os opióides, os benzodiazepínicos, o zolpidem, o entacapone e a ketamina foram eficazes no tratamento da síndrome das pernas inquietas. Um estudo mostrou que o ferro não foi eficaz. CONCLUSÕES: Baseado nos poucos estudos duplo-cegos, randomizados e controlados, parece que as melhores opções para tratar os pacientes com síndrome das pernas inquietas são a gabapentina e L-dopa associada à sua formulação de liberação lenta.

  6. Intoxicación por drogas Drug poisoning

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    I. Gainza

    2003-01-01

    Full Text Available El consumo de drogas ilegales en nuestro país ha experimentado un notable cambio en los últimos años, relegando a la heroína e incorporando la cocaína, los derivados anfetamínicos como el "éxtasis" (MDMA, el "éxtasis líquido" (GHB y, en menor medida, la ketamina. Se lleva a cabo una revisión de la intoxicación aguda por opiáceos y de su tratamiento en los servicios de urgencias, teniendo en cuenta el descenso progresivo de los casos que se presentan con el advenimiento de nuevas formas de administración, así como la presencia de nuevas drogas adictivas que han dado lugar a un desplazamiento en los hábitos de consumo. Se expone la intoxicación por cocaína haciendo referencia a la clínica, el diagnóstico y el tratamiento. Se realiza una revisión sobre el cannabis y sus derivados, la historia de su consumo y preparaciones utilizadas, los efectos que producen en los distintos sistemas del organismo y sus principales mecanismos de acción. Por último se comentan los efectos del LSD y de las setas alucinógenas.A review is made of acute poisoning by opiates and its treatment in the emergency services, bearing in mind the progressive decline in the number of cases presented with the arrival of new forms of their administration, as well as the presence of new addictive drugs that have resulted in a shift in consumption habits. Reference is also made to the way in which the different types of existing substances originated, with the aim of achieving a better understanding of their use and in order to administer the most suitable treatment when poisoning occurs. Cocaine poisoning is discussed, with reference to its clinical picture, diagnosis and treatment. The consumption of illegal drugs in our country has undergone a notable change in recent years, with heroin being relegated and the incorporation of cocaine, amphetamine derivatives such as "ecstasy" (MDMA, "liquid ecstasy" (GHB and, to a lesser extent, ketamine. A review is made

  7. ZASTOSOWANIE SIECI NEURONOWYCH TYPU HOPFIELDA W DIAGNOSTYCE NAWIERZCHNI DROGOWYCH

    Directory of Open Access Journals (Sweden)

    Marcin STANIEK

    2016-07-01

    Full Text Available Artykuł dotyczy zagadnień diagnostyki nawierzchni drogowych z wykorzystaniem metod przetwarzania obrazów cyfrowych wspomaganych zastosowaniem sieci neuronowej typu Hopfielda w procesie wzajemnego dopasowania pikseli pary obrazów nawierzchni drogi. Para obrazów rejestrowana z wykorzystaniem stereowizyjnego mobilnego stanowiska pomiarowego, opracowanego przez autora, definiowana jest jako stereo-obraz drogi. W artykule opisano ograniczenia rozwiązań stereowizyjnych oraz przedstawiono problem niejednoznaczności dopasowania dla obszarów o jednakowej intensywności. Określono problem obiektów przesłaniających się w polu widzenia kamer, zidentyfikowano ograniczenia ciągłości wynikające z nagłej zmiany funkcji intensywności obrazów, oraz zwrócono uwagę na typowe ograniczenia związane z przetwarzaniem i rozpoznawaniem obrazów cyfrowych. Podczas implementacji sieci neuronowej zdefiniowano kryteria, których minimalizacja jako składowych funkcji energii pozwoliła na uzyskanie optymalnego dopasowania pikseli stereo-obrazów, tym samym właściwego odwzorowania nawierzchni drogowej. Do rozwiązania zadania optymalizacji wielokryterialnej zaproponowano kryteria maksymalizacji i jednoznaczności dopasowania pikseli oraz kolejności przyporządkowania sekwencji pikseli w obu stereo-obrazach, a także kryterium ciągłości mapy dysparycji. Opis matematyczny składowych energii sieci neuronowej określono w artykule. Ocenę zastosowania sieci neuronowej zdefiniowano jako różnicę pomiędzy pomiarami głębi z wykorzystaniem sieci neuronowej oraz bez jej zastosowania. Do oceny zaproponowanego rozwiązania przeprowadzono pomiary z wykorzystaniem mobilnego stanowiska stereowizyjnego, które porównano z pomiarami statycznymi z wykorzystaniem skanowania laserowego w zdefiniowanych przekrojach pomiarowych drogi. Zastosowana sieć neuronowa typu Hopfielda pozwoliła na zwiększenie liczby pikseli poprawnie przypisanych w

  8. Skórna postać leiszmaniozy u pacjenta powracającego z Maroka

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    Aleksander Garlicki

    2010-09-01

    Full Text Available Wprowadzenie: Leiszmanioza jest tropikalną chorobą pasożytniczą,wywołaną przez pierwotniaki z rodzaju Leishmania. RezerwuaremLeishmania są ludzie i zwierzęta, a wektorem przenoszącym pasożytakomary z rodzaju Phlebotomus i Lutzomyia. Wyróżnia się trzy postaciechoroby: skórną, śluzówkowo-skórną i trzewną. Cel pracy: Zwrócenie uwagi na narastający problem zawlekaniachorób z krajów tropikalnych i trudności w rozpoznaniu skórnej lei szmaniozy. Opis przypadku: Pacjent, lat 29, został przyjęty do Kliniki z powoduowrzodzenia II palca stopy lewej po powrocie z 16-dniowego pobytuw Maroku. Początkowo był diagnozowany w miejscu zamieszkania,gdzie wykluczono leiszmaniozę, opierając się na negatywnych wynikachbadań zeskrobin skórnych i testów serologicznych. Po przyjęciudo Kliniki pobrano wycinek ze zmiany skórnej palca do badania histopatologicznego,w którym stwierdzono zmiany sugerujące tę chorobę.Do leczenia włączono ketokonazol na 4 tygodnie, uzyskując niewielkąpoprawę. Po tej terapii obserwowano stałą, choć wolną, poprawę miejscowąi po kolejnych 3 miesiącach doszło do całkowitego wygojeniazmian skórnych. Wnioski: W procesie diagnostycznym skórnej leiszmaniozy należyuwzględnić ocenę histopatologiczną wycinka ze zmiany. W związkuz coraz częstszymi wyjazdami do stref występowania leiszmaniozynależy oczekiwać zwiększenia liczby przypadków tej choroby w Polsce.

  9. Transtorno de estresse pós-traumático em pacientes de unidade de terapia intensiva Post-traumatic stress disorder in intensive care unit patients

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    Andrea Vannini Santesso Caiuby

    2010-03-01

    Full Text Available O transtorno de estresse pós-traumático tem sido descrito em pacientes após tratamento em unidade de terapia intensiva. O objetivo foi revisar estudos sobre os aspectos psicológicos e as intervenções terapêuticas destes pacientes após internação em unidade de terapia intensiva. Trinta e oito artigos foram incluídos. A prevalência de transtorno de estresse pós-traumático variou de 17% a 30% e a incidência de 14% a 24%. Os fatores de risco foram: história prévia de ansiedade, depressão ou pânico, ter memórias traumáticas ilusórias (memórias derivadas de formações psíquicas como sonho e delirium, tempo de ventilação mecânica, experiências estressantes, crenças e comportamentos de característica depressiva. Doses altas de opióides, sintomas na retirada da sedação ou analgesia e o uso de lorazepam foram relacionados ao aumento de delirium e de memória ilusória. A sintomatologia do transtorno pode ser reduzida com a administração de hidrocortisona, com a interrupção diária da sedação e não foram encontrados estudos de efetividade de intervenção psicológica.Post-traumatic stress disorder has been detected in patients after treatment in intensive care unit. The main goal of this study is to review the psychological aspects and therapeutic interventions on those patients after their treatment on intensive care unit. Thirty eight articles have been included. The prevalence of post-traumatic stress disorder has varied from 17% up to 30% and the incidence from 14% to 24%. The risk factors were: previous anxiety historic, depression or panic, having delusional traumatic memories (derived from psychic formations as dreams and delirium, belief effects, depressive behavior, stressing experiences and mechanical ventilation. High doses of opiates, symptoms caused by sedation or analgesia reduction and the use of lorazepam were related with the increase of delirium and delusional memory. The disorder sintomatology

  10. Tolerabilidad y eficacia de la morfina versus hidromorfona en analgesia epidural posquirúrgica con bupivacaína en un hospital universitario: ensayo ciego, con asignación aleatoria

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    Wilson Lescano

    2008-11-01

    Full Text Available OBJETIVO: comparar la frecuencia de efectos adversos (prurito, retención urinaria, náuseas, vómito, sedación y la eficacia analgésica entre hidromorfona y morfina en la analgesia epidural posoperatoria. MÉTODOS: ensayo clínico prospectivo, aleatorizado, ciego, para comparar los efectos adversos frecuentes relacionados con la morfina y la hidromorfona en dosis equivalentes asociadas a bupivacaína por vía epidural, en pacientes programados para cirugía mayor. Cada paciente recibió una combinación de hidromorfona 10 g/mL más bupivacaína al 0,1% (Grupo 1, HB o morfina 30 g/mL más bupivacaína 0,1% (Grupo 2, MB.Los pacientes se evaluaron a las 24 horas posoperatorias y se registraron los efectos adversos. RESULTADOS: participaron 142 pacientes: 71 en el Grupo HB y 71 en el Grupo MB. Las frecuencias de efectos adversos fueron como sigue en los grupos HB y MB, respectivamente: náuseas 31% y 36,6% (p = 0,54; vómito 25,4% y 19,7% (p = 0,42; sedación 14,1% y 15,5% (p =0,81; retención urinaria 7% y 11,3% (p = 0,38; prurito 31% y 43,7% (p = 0,11. No hubo diferencias estadísticamente significativas entre los dos grupos. La media en la escala verbal numérica medida a las 24 horas para dolor dinámico fue de 2,82 (± 2,5 y de 3,42 (± 2,8 para los grupos HB y MB, respectivamente (p = 0,16. La media de dolor en reposo tampoco mostró diferencia significativa. CONCLUSIÓN: no hay diferencias en la tolerabilidad entre la morfina 30 g /mL y la hidromorfona 10 g/mL como parte de un esquema combinado con bupivacaína al 0,1% para analgesia epidural posoperatoria y ambos opiáceos proveen analgesia efectiva y comparable.

  11. Aspectos neurofarmacológicos do uso crônico e da Síndrome de Abstinência do Alcool Neuropharmacological aspects of chronic alcohol use and withdrawal syndrome

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    Marcos Zaleski

    2004-05-01

    Full Text Available O objetivo deste artigo é o de revisar e descrever as principais alterações neurofarmacológicas causadas pela exposição crônica ao álcool, assim como os fenômenos ocorridos durante o período de abstinência. São apresentados dados referentes às alterações neuroadaptativas e de tolerância ocorridas nos principais sistemas de monoaminas, aminoácidos neurotransmissores e canais de cálcio, o que está relacionado a uma piora no prognóstico de portadores de comorbidades psiquiátricas com o consumo de álcool. São também descritos alguns estudos relevantes que demonstram o envolvimento de outros mecanismos de ação do álcool no sistema nervoso central, como o envolvimento de opióides, entre outras substâncias. O artigo reafirma a importância, para clínicos e pesquisadores, de um sempre maior entendimento do mecanismo de ação central do álcool, pois dele depende a busca por novas opções farmacológicas, tanto para a redução dos danos provocados pelo seu uso crônico, como para o tratamento da síndrome de abstinência a esta substância.The objective of this paper is to review and describe the main neuropharmacological changes caused by the chronic use of alcohol and those observed during its withdrawal period. The results show international data referring to the involvement of monoamine systems, neurotransmitters and calcium channels in both neuroadaptation and tolerance to alcohol effects and withdrawal. Relevant studies showing the participation of other systems in those mechanisms, as opioids and other substances, are also shown. The article reinforces the importance, for both physicians and researchers, of an always growing understanding of alcohol central mechanisms of action. This understanding is necessary to new pharmacological options to alcohol harm reduction as well as to alcohol withdrawal treatment.

  12. THE SLAVO-RUSSIAN EUCHOLOGION OF THE GREAT CHURCH AND ITS GREEK ORIGINAL

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    T. I. Afanas’eva

    2015-01-01

    Full Text Available The following article looks at the composition of the Slavo-Russian Euchologion of the Great Church according to State Historical Museum (Moscow manuscript Syn.900 incomparison with three Greek copies of this work, which were introduced by Miguel Arranz (Paris, Coisl.213, Grottaferrata, Γ.β.Ι. and Athens 662. It is concluded that the Slavo-Russian version, created at the turn of the XIV–XV centuries, serves as evidence for existence of a new edition of the Euchologion of theGreatChurch, which was most likely completed under Patriarch Philotheus. This edition of the  Euchologion  preserved  many  unique  features  of  the  oldest  Greek  сopy  – Coisl. 213 of 1027, which was written at the request of priest Strategius from thechurchofSt. Sophia. In this way, it preserved, more than other Greek copies of the patriarchal prayer books, the rites of the Holy Week performed in the Great church as well as lities for different places inConstantinople, and prayers for various needs. In addition, it also included a number of new rites and prayers for monastic tonsure, communion and repentance, as well as had an inserted Church New Year rite, edited by Patriarch Philotheus. The structure of the ᾀσματικὴ ἀκολουθία went through serious changes: it was re-arranged and broken up into two parts. The Slavonic scribe translated only some services that were in the Greek codex, that is only those that were previously unknown or not very well known in Rus’. For instance, the Slavonic version does not include rites of baptism, marriage, burial, Great Blessing of Water, or the Prayer of Genuflection for the Holy Week, all of which were widely known in Rus’. When translating theConstantinoplerites, the Russian scribe left out all of the toponyms, which, as the author of this article thinks, shows his attempt to adapt these services to the Russian ones.

  13. Uso abusivo de benzidamina no Brasil: uma abordagem em farmacovigilância Use abusive of benzydamine in Brazil: an overview in pharmacovigilance

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    Daniel Marques Mota

    2010-05-01

    Full Text Available O uso abusivo de medicamentos tem sido objeto de crescente interesse em saúde pública e geralmente veiculado na imprensa brasileira. Dentre os medicamentos, objeto de abuso e que causam dependência física e/ou psíquica, incluemse os barbitúricos, benzodiazepínicos, analgésicos opióides e anfetaminas. Os analgésicos, antitérmicos e antiinflamatórios não esteroidais, apesar de não fazerem parte dessa relação de fármacos, estão, geralmente, associados ao uso recreativo ou fins não terapêuticos. O objetivo deste ensaio é apresentar informações sobre o uso abusivo de benzidamina no Brasil. Trata-se de um estudo descritivo do tipo exploratório, em que foram utilizadas diferentes estratégias metodológicas adotadas na prática de regulação em farmacovigilância. O uso abusivo desse fármaco foi constatado na literatura científica, imprensa e internet. Em função da facilidade na compra de medicamentos sujeitos à prescrição médica, entre outros fatores, devem-se exigir meios e formas para monitorar a comercialização e utilização de medicamentos, assegurando seu uso seguro e racional, incluindo o fortalecimento da farmacovigilância no Brasil.The abusive drug use has been object of increasing concern in public health and is commonly issued in the Brazilian press. Amongst medicines, those that are abuse substances and cause physical and/or psychic dependence, barbiturates, benzodiazepines, opioid analgesics and amphetamines are included. Analgesics, antipyretics and non-steroidal anti-inflammatory drugs, even not making part of this list, are generally associated with recreational use or non therapeutical purpose. The objective of this essay is to present information on the abusive use of benzydamine in Brazil. The present study is an exploratory essay in which different methodological strategies adopted in the regulatory practice of pharmacovigilance have been used. The abusive use of this drug was evidenced in

  14. HIGH-TEMPERATURE SAFETY TESTING OF IRRADIATED AGR-1 TRISO FUEL

    Energy Technology Data Exchange (ETDEWEB)

    Stempien, John D.; Demkowicz, Paul A.; Reber, Edward L.; Chrisensen, Cad L.

    2016-11-01

    primary goals. First, the test was intended to assess the retention of fission products in loose kernels without the effects of the other TRISO layers (buffer, IPyC, SiC, and OPyC) or the graphitic matrix material comprising the compact. Second, this test served as an evaluation of the FACS fission product condensation plate collection efficiency.

  15. Memantyna w leczeniu zaburzeń afektywnych

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    Dominik Strzelecki

    2011-06-01

    Full Text Available Celem pracy było przedstawienie właściwości przeciwdepresyjnych i normotymicznych memantyny, leku obecnie zarejestrowanego w leczeniu cięższych postaci otępienia typu alzheimerowskiego. W pracy, oprócz przybliżenia podstawowych informacji na temat tej substancji, skupiliśmy się na przedstawieniu dotychczas opublikowanych wyników jej stosowania w zaburzeniach afektywnych. Dostępne piśmiennictwo klinicznych zastosowań memantyny jest w tym zakresie bardzo ubogie, obejmuje pojedyncze badania w niewielkich grupach pacjentów z zaburzeniami depresyjnymi nawracającymi, w manii w przebiegu choroby afektywnej dwubiegunowej, jak również kilka opisów kazuistycznych, w tym w epizodzie depresyjnym w przebiegu zaburzenia dwubiegunowego. Wstępne wyniki są dość optymistyczne, jakkolwiek nie upoważniają na obecnym etapie do jednoznacznych konkluzji. Podkreślane jest duże bezpieczeństwo stosowania memantyny oraz, co oczywiste, potrzeba przeprowadzenia kolejnych, dobrze zaplanowanych metodologicznie badań, które objęłyby większe grupy pacjentów, a także oceniałyby działanie memantyny u chorych z depresją dwubiegunową czy epizodem mieszanym ChAD. Ze względu na szybkie działanie kliniczne antagonistów glutaminianergicznego receptora NMDA memantyna byłaby interesującą i wygodną alternatywą terapeutyczną, z perspektywy zastosowania w codziennej pracy klinicznej znacznie korzystniejszą, dużo bezpieczniejszą i łatwiejszą w zastosowaniu od ketaminy, innego antagonisty NMDA. Co wydaje się szczególnie ważne, memantyna daje potencjalnie szansę na poprawę funkcjonowania poznawczego, co jest wykorzystywane w terapii otępień, zaś w zaburzeniach afektywnych dotychczas praktycznie nie było badane.

  16. Efeito antinociceptivo e antiinflamatório do extrato aquoso da entrecasca de Coutarea hexandra Schum. (Rubiaceae Antinociceptive and anti-inflammatory properties of Coutarea hexandra barks aqueous extract Schum. (Rubiaceae

    Directory of Open Access Journals (Sweden)

    Josefina E.X. Lucena

    2006-03-01

    Full Text Available No estado de Sergipe, o chá da entrecasca de Coutarea hexandra Shum. (Rubiaceae é popularmente utilizado no combate à dor e à inflamação. Estes usos etnofarmacológicos vieram motivar os estudos sobre os efeitos antinociceptivo e antiinflamatório, bem como sobre a toxicidade aguda do extrato aquoso liofilizado da entrecasca de Coutarea hexandra. Doses orais do extrato aquoso significativamente reduziram as contorções abdominais induzidas por ácido acético, aumentaram o tempo de latência ao calor no teste da placa quente, reduziram o edema de pata induzido por carragenina e, na segunda fase do teste da formalina, também reduziram a resposta dos animais à formalina. O efeito detectado no teste da formalina não foi revertido por naloxona ou cafeína. Nos ensaios de toxicidade aguda, não foi observada a morte de nenhum animal até a dose de 5 g/kg. Em conclusão, o extrato aquoso da entrecasca de C. hexandra possui efeitos antiinflamatório e antinociceptivo e não apresenta toxicidade aguda em camundongos. O efeito antinociceptivo não está relacionado à ativação dos sistemas opióide e adenosina e, ao menos parcialmente, é decorrente da atuação do extrato aquoso em nível central.The aqueous extract of Coutarea hexandra Shum. (Rubiaceae is extensively used on local folk medicine as anti-inflammatory and antinociceptive. In view of these facts, it was of our interest to evaluate the anti-inflammatory and antinociceptive activities. Its acute toxicity was also evaluated. The aqueous extract of Coutarea hexandra reduced acetic acid-induced writhing, increased the latency in the hot plate test, and reduced the second phase nociceptive response in the formalin test. Neither naloxone nor caffeine reversed aqueous extract of Coutarea hexandra effect in the second phase of the formalin test. The aqueous extract of Coutarea hexandra also reduced the rat paw edema induced by carrageenan. There was no animal death with doses up to 5 g

  17. Growth hormone therapy in a girl with Turner syndrome and diabetes type 1 - case report.

    Science.gov (United States)

    Obara-Moszynska, Monika; Banaszak, Magdalena; Niedziela, Marek

    2015-01-01

    Wstęp. Badania wskazują na złożoną etiologię nieprawidłowego metabolizmu węglowodanów w zespole Turnera (ZT). W związku z tymi zaburzeniami leczenie rekombinowanym hormonem wzrostu (rGH ) w ZT może być związane z powikłaniami, szczególnie że hormon wzrostu ma działanie diabetogenne. Opis przypadku. Wywiad okołoporodowy jest nieznany (pacjent adoptowany w wieku 4 lat). W wieku 11 lat ze względu na typowy fenotyp rozpoznano ZT. Kariotyp: 45,X[43]/46,X,i(X)(q10)[7]. W tym samym wieku rozpoznano cukrzycę insulinozależną na podstawie wyników laboratoryjnych. Rozpoczęto konwencjonalną insulinoterapię. W trakcie hospitalizacji, w wieku 12 lat, wzrost wynosił 123,5 cm (- 4,4 SD), W tym samym wieku rozpoczęto leczenie rGH w dawce 0,045 mg/kg mc/dobę. Po 3 miesiącach tempo wzrastania zwiększyło się do 8,2 cm/rok. W wieku 13 lat zainicjowano terapię preparatem 17β-estradiolu. Po upływie 3 lat i 4 miesięcy leczenie rGH przerwano z powodu niskiego tempa wzrastania. Wzrost dziewczynki wynosił 140 cm (-4SD). Dwa lata po zakończeniu leczenia rGH wzrost wynosił 141,2 cm. Po zakończeniu leczenia rGH zapotrzebowanie dzienne na insulinę zmniejszyło się z 50–60 jm./dobę do 38–44 jm./dobę. Wnioski. Decyzja włączenia terapii rGH w ZTz cukrzycą jest z pewnością trudna. W momencie rozpoczęcia lecze­nia rGH klinicysta musi mieć na uwadze ryzyko powikłań metabolicznych, ale także świadomość, że daje pacjen­towi szansę na poprawę wzrostu końcowego. Z punktu widzenia prawidłowego rozwoju psychoemocjonalnego zmniejszenie deficytu wzrostu jest bardzo ważne.

  18. Seasonal forecasts of drought indices in African basins

    Science.gov (United States)

    Dutra, Emanuel; Di Giuseppe, Francesca; Wetterhall, Fredrik; Pappenberge, Florian

    2013-04-01

    Vast parts of Africa rely on the rainy season for livestock and agriculture. Droughts can have a severe impact in these areas which often have a very low resilience and limited capabilities to mitigate drought impacts. In this work we assess the predictive capabilities of an integrated drought monitoring and seasonal forecasting system (up to 5 months lead time) based on the Standardized Precipitation Index (SPI). The system is constructed by extending near real-time monthly precipitation fields (ERA-Interim reanalysis and the Climate Anomaly Monitoring System-Outgoing Longwave Radiation Precipitation Index, CAMS-OPI) with monthly forecasted fields as provided by the European Centre for Medium-Range Weather Forecasts (ECMWF) seasonal forecasting system. This new seamless approach to merge monitoring and forecasting fields of precipitation to generate SPI at different time-scales is evaluated within the framework of the EU project DEWFORA. In particular, the evaluation was preformed over four basins in Africa: the Blue Nile, Limpopo, Upper Niger, and Upper Zambezi. There are significant differences in the quality of the precipitation between the datasets depending on the catchments, and a general statement regarding the best product is difficult to make. All the datasets show similar spatial and temporal patterns in the South and North West Africa, while there is a low correlation in the equatorial area which makes it difficult to define ground truth and choose an adequate product for monitoring. The Seasonal forecasts have a higher reliability and skill in the Blue Nile, Limpopo and Upper Niger in comparison with the Zambezi. This skill and reliability depends strongly on the SPI time-scale, and more skill is observed at longer time-scales. The ECMWF seasonal forecasts have predictive skill which is higher than using climatology for most regions. In regions where no reliable near real-time data is available, the seasonal forecast can be used for monitoring (first

  19. SU-E-T-25: A Dosimetric Comparison of Three-Dimension Conformal and Intensity-Modulated Radiation Therapy in Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo, N; Maneru, F; Fuentemilla, N; Olasolo, J; Gracia, M; Pellejero, S; Bragado, L; Lozares, S; Miquelez, S; Martin, M [Complejo Hospitalario de Navarra, Pamplona, Navarra (Spain)

    2015-06-15

    Purpose: dosimetric comparison of 3DCRT and IMRT in 9 esophageal cancer. The aim of this paper is to know which of these two techniques is dosimetrically more favorable dosimetrically at both the CTV coverage and dose obtained in the relevant organs at risk, in this case, lungs and heart, as the spinal cord received in all cases below 45 Gy. Methods: we chose 9 patients from our center (CHN) with the same type of esophageal cancer and in which the prescribed dose was the same, 54 Gy. For these treatments we have used the same fields and the same angles (AP (0 °), OPD (225°–240°) and OPI (125°–135°)).All plans have been implemented using Eclipse (version 11.0) with AAA( Analytical Anisotropic Algorithm )(Version 11.0.31). Results: To analyze the coverage of the CTV, we have evaluated the D99% and found that the average dose received by 99% of CTV with IMRT is 53.8 ± 0.4 Gy (99.6% of the prescribed dose) and the mean value obtained with 3DCRT is 52.3 ± 0.6 Gy (96.8% of the prescribed dose).The last data analyzed was the D2% of PTV, a fact that gives us information on the maximum dose received by our PTV. D2% of the PTV for IMRT planning is 55.4 ± 0.4 Gy (102.6% of the prescribed dose) and with 3DCRT is 56.8 ± 0.7 Gy (105.2% of the prescribed dose).All parameters analyzed at risk organs (V30, V40, V45 and V50 for the case of heart and V5, V10, V15 and V20 for the case of the lungs) provide us irradiated volume percentages lower in IMRT than 3DCRT. Conclusion: IMRT provides a considerable improvement in the coverage of the CTV and the doses to organs at risk.

  20. Community ecology and spatial distribution of trees in a tropical wet evergreen forest in Kaptai national park in Chittagong Hill Tracts, Bangladesh

    Institute of Scientific and Technical Information of China (English)

    S.M.Feroz; Md Rabiul Alam; Prokash Das; Abdullah Al Mamun

    2014-01-01

    We investigated the floristic composition, woody species diversity and spatial distribution of trees in a tropical wet evergreen forest in Kaptai national park in Chittagong Hill Tracks, Bangladesh. We recorded 25 families, 37 genera, 40 species and 1771 woody individuals in a 0.09 ha plot. Euphorbiaceae and Moraceae were the most species-rich families, and Castanopsis, Ficus and Terminalia were the most species-rich genera. Bursera serrata Wall. ex Colebr. was the dominant species in terms of highest importance value (13%). Trema orientalis (L.) Bl was typically a light demanding species as it appeared in the top can-opy with only one individual having the seventh highest IV, but had no regeneration. The expected maximum number of species (Smax) was 140, indicating that many species may invade the forest as the Smax is greater than the recorded total number of species. The nature of the disappear-ance and appearance of species in the present forest reflects instability of floristic composition. The values of Shannon’s index H′ and Pielou’s index J′ (evenness) were 3.36 bit and 0.63, respectively. These values show moderately high species diversity as compared to other subtropical forests in the tropics. In addition, a sample area of 200 m2 in this forest would be sufficient for measuring the diversity indices H′ and J′ , whereas the trend of J′may indicate the rate of equality of individuals among the different species decreased with increasing area. The distribu-tion pattern for the total stand was completely random. However, the dominant species showed aggregate distribution for small areas, but random distribution for large areas. The spatial association between species showed that the strongest positive interspecific association oc-curred between Streblus asper Lour. and Castanea indica Roxb. (ω =0.51). As a whole, most species were weakly associated with each other, of which 58%species associations were completely negative. The result of

  1. Acceptance Test Data for the AGR-5/6/7 Irradiation Test Fuel Composite Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-05-01

    Coated particle composite J52R-16-98005 was produced by Babcock and Wilcox Technologies (BWXT) as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). This composite was comprised of four coated particle fuel batches J52O-16-93165B (26%), 93168B (26%), 93169B (24%), and 93170B (24%), chosen based on the Quality Control (QC) data acquired for each individual candidate AGR-5/6/7 batch. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT Lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A). Secondary upgrading by sieving was performed on the A-designated batches to remove particles with missing or very-thin buffer layers that were identified during previous analysis of the individual batches for defective IPyC, as reported in the acceptance test data report for the AGR-5/6/7 production batches [Hunn et al. 2017]. The additionally-upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93165B).

  2. Prevención del suicidio en médicos

    Directory of Open Access Journals (Sweden)

    José Carlos Mingote Adán

    2013-06-01

    Full Text Available Se sabe que la tasa de suicidio en médicos es mayor que en la población general. La salud de los médicos ha recibido escasa atención de sus colegas, a pesar de la considerable y creciente evidencia de que la morbilidad es alta en la profesión. Cuidar de otras personas genera estrés en los cuidadores. El estrés por la incertidumbre clínica y el temor al fracaso son rasgos importantes de la cultura médica. La paradoja es que el cuidado de los pacientes genera estrés pero es también la fuente de gratificación más importante del médico. Se sabe que aquellos que cuidan de los demás a menudo tienen grandes dificultades para buscar y recibir ayuda para ellos mismos. Las tasas de suicidio de los médicos en Estados Unidos, Inglaterra y otros países son más altas que las de la población general y las de otras profesiones. La tasa de suicidio de los médicos es ligeramente mayor que la de la población general, mientras que la de las médicas es claramente superior. Esta tendencia es más pronunciada entre psiquiatras y anestesistas. Los médicos tienen unas necesidades asistenciales específicas por sufrir elevados niveles de alcoholismo, dependencia de drogas, rupturas matrimoniales, enfermedad mental y suicidio. La automedicación es muy frecuente entre los médicos, en especial con hipnóticos, antidepresivos y analgésicos opiáceos. Muchas de estas dificultades están relacionadas con el estrés, elevada responsabilidad y tiempo insuficiente para trabajar y vivir conciliando las demandas laborales y familiares. Muchos médicos tienen grandes dificultades para discutir sus problemas con los colegas y se tratan a ellos mismos, de forma notablemente peligrosa. El fácil acceso de los médicos a las drogas implica que el abuso de drogas sea un riesgo ocupacional potencial de hombres y mujeres.

  3. miRNA Signatures in Sera of Patients with Active Pulmonary Tuberculosis

    Science.gov (United States)

    Valente, Ilaria C.; Norbis, Luca; Sotgiu, Giovanni; Bosu, Roberta; Ambrosi, Alessandro; Codecasa, Luigi R.; Goletti, Delia; Matteelli, Alberto; Ntinginya, Elias N.; Aloi, Francesco; Heinrich, Norbert; Reither, Klaus; Cirillo, Daniela M.

    2013-01-01

    Several studies showed that assessing levels of specific circulating microRNAs (miRNAs) is a non-invasive, rapid, and accurate method for diagnosing diseases or detecting alterations in physiological conditions. We aimed to identify a serum miRNA signature to be used for the diagnosis of tuberculosis (TB). To account for variations due to the genetic makeup, we enrolled adults from two study settings in Europe and Africa. The following categories of subjects were considered: healthy (H), active pulmonary TB (PTB), active pulmonary TB, HIV co-infected (PTB/HIV), latent TB infection (LTBI), other pulmonary infections (OPI), and active extra-pulmonary TB (EPTB). Sera from 10 subjects of the same category were pooled and, after total RNA extraction, screened for miRNA levels by TaqMan low-density arrays. After identification of “relevant miRNAs”, we refined the serum miRNA signature discriminating between H and PTB on individual subjects. Signatures were analyzed for their diagnostic performances using a multivariate logistic model and a Relevance Vector Machine (RVM) model. A leave-one-out-cross-validation (LOOCV) approach was adopted for assessing how both models could perform in practice. The analysis on pooled specimens identified selected miRNAs as discriminatory for the categories analyzed. On individual serum samples, we showed that 15 miRNAs serve as signature for H and PTB categories with a diagnostic accuracy of 82% (CI 70.2–90.0), and 77% (CI 64.2–85.9) in a RVM and a logistic classification model, respectively. Considering the different ethnicity, by selecting the specific signature for the European group (10 miRNAs) the diagnostic accuracy increased up to 83% (CI 68.1–92.1), and 81% (65.0–90.3), respectively. The African-specific signature (12 miRNAs) increased the diagnostic accuracy up to 95% (CI 76.4–99.1), and 100% (83.9–100.0), respectively. Serum miRNA signatures represent an interesting source of biomarkers for TB disease with the

  4. miRNA signatures in sera of patients with active pulmonary tuberculosis.

    Directory of Open Access Journals (Sweden)

    Paolo Miotto

    Full Text Available Several studies showed that assessing levels of specific circulating microRNAs (miRNAs is a non-invasive, rapid, and accurate method for diagnosing diseases or detecting alterations in physiological conditions. We aimed to identify a serum miRNA signature to be used for the diagnosis of tuberculosis (TB. To account for variations due to the genetic makeup, we enrolled adults from two study settings in Europe and Africa. The following categories of subjects were considered: healthy (H, active pulmonary TB (PTB, active pulmonary TB, HIV co-infected (PTB/HIV, latent TB infection (LTBI, other pulmonary infections (OPI, and active extra-pulmonary TB (EPTB. Sera from 10 subjects of the same category were pooled and, after total RNA extraction, screened for miRNA levels by TaqMan low-density arrays. After identification of "relevant miRNAs", we refined the serum miRNA signature discriminating between H and PTB on individual subjects. Signatures were analyzed for their diagnostic performances using a multivariate logistic model and a Relevance Vector Machine (RVM model. A leave-one-out-cross-validation (LOOCV approach was adopted for assessing how both models could perform in practice. The analysis on pooled specimens identified selected miRNAs as discriminatory for the categories analyzed. On individual serum samples, we showed that 15 miRNAs serve as signature for H and PTB categories with a diagnostic accuracy of 82% (CI 70.2-90.0, and 77% (CI 64.2-85.9 in a RVM and a logistic classification model, respectively. Considering the different ethnicity, by selecting the specific signature for the European group (10 miRNAs the diagnostic accuracy increased up to 83% (CI 68.1-92.1, and 81% (65.0-90.3, respectively. The African-specific signature (12 miRNAs increased the diagnostic accuracy up to 95% (CI 76.4-99.1, and 100% (83.9-100.0, respectively. Serum miRNA signatures represent an interesting source of biomarkers for TB disease with the potential to

  5. WPŁYW SUBSTYTUCJI WŁÓKIEN BAZALTOWYCH PRZEZ WŁÓKNA WĘGLOWE NA WŁAŚCIWOŚCI MECHANICZNE PRĘTÓW B/CFRP (HFRP

    Directory of Open Access Journals (Sweden)

    Kostiantyn PROTCHENKO

    2016-07-01

    Full Text Available W niniejszym artykule przedstawiono analityczne i numeryczne obliczenia mechanicznych właściwości obecnie opracowywanych prętów hybrydowych HFRP (Hybrid Fibre Reinforced Polymer powstałych poprzez zastąpienie (substytucję części włókien bazaltowych BFRP (Basalt Fibre Reinforced Polymer włóknami węglowymi CFRP (Carbon Fibre Reinforced Polymer. W tym aspekcie termin ,,substytucja” rozumiany będzie jako modyfikacja prętów BFRP polegająca na zastąpieniu pewnej części włókien bazaltowych przez włókna węglowe. Celem analizy jest określenie optymalnego modelu prętów hybrydowych HFRP, które stanowiłyby realną alternatywę dla prętów stalowych stosowanych do zbrojenia konstrukcji betonowych. Zamiana włókien bazaltowych, włóknami węglowymi prowadzi do uzyskania lepszych właściwości mechanicznych prętów. Względy ekonomiczne skłaniają do ograniczenia procentowego udziału włókien węglowych w prętach HFRP do rozsądnej wielkości, oraz zastosowaniu włókien węglowych o stosunkowo niedużej wytrzymałości (Low Strength Carbon Fibres jak na włókna CFRP. W pracy przedstawiony został opis struktury pręta hybrydowego, oszacowanie właściwości mechanicznych wzdłuż i w poprzek włókien, a także wpływ układu włókien w przekroju poprzecznym pręta na jego zachowanie mechaniczne. Analizę przeprowadzono dla różnych proporcji udziału włókien węglowych do włókien bazaltowych (1:9; 1:4; 1:3; 1:2; 1:1 w prętach HFRP. Rozpatrzono dwa przypadki rozmieszczenia włókien w przekroju poprzecznym pręta (Bar Architecture. Pierwszy z włóknami węglowymi zlokalizowanymi w rdzeniu, natomiast drugi z włóknami węglowymi usytuowanymi w powierzchniowej warstwie pręta.

  6. Los determinantes institucionales de las patentes del Consejo Superior de Investigaciones Científicas: una aproximación histórica y una dialéctica con la Economía

    Directory of Open Access Journals (Sweden)

    Azagra Caro, Joaquín M.

    2009-06-01

    Full Text Available To date, normative studies on the generation of public patents have focused on universities. This paper extends the analysis to public research organisations (PRO. From both a historic and economic standpoint, and via the interpretation of three institutional factors (the change in the political and legal background, the dominance of certain areas of science over others, and the increase in technological cooperation, the reasons moving the Consejo Superior de Investigaciones Científicas (CSIC; the Spanish Research Council to file patents were examined. The impact of these quantified factors on patenting was examined from 1987 to the present. The institutional framework of bodies such as the CSIC was found to favour a patenting culture. The historical approach adopted defined homogeneous analytical periods and guided the interpretation of the results and their effects over time, while the economic approach allowed some of the relationships seen to be quantified and questioned the validity of merely descriptive classifications (e.g., scientific areas according to number of patents.

    Hasta la fecha los estudios normativos sobre el origen de patentes públicas han estado centrados en las patentes universitarias. Con este artículo extendemos el análisis a las patentes generadas en los organismos públicos de investigación (OPI. Desde una doble perspectiva, la histórica y la económica, y a través de la interpretación de tres factores institucionales (evolución de los cambios políticos y legales, primacía de unas áreas científicas sobre otras y aumento de la cooperación tecnológica se analiza qué lleva al Consejo Superior de Investigaciones Científicas (CSIC a patentar. Para el último período, desde 1987, hemos cuantificado el impacto de estos factores en las patentes. Hemos concluido que el marco institucional resulta eficaz en un organismo como el CSIC para crear una cultura favorable a la patente. La aproximación hist

  7. Analysis of Natural Graphite, Synthetic Graphite, and Thermosetting Resin Candidates for Use in Fuel Compact Matrix

    Energy Technology Data Exchange (ETDEWEB)

    Trammell, Michael P [ORNL; Pappano, Peter J [ORNL

    2011-09-01

    The AGR-1 and AGR-2 compacting process involved overcoating TRISO particles and compacting them in a steel die. The overcoating step is the process of applying matrix to the OPyC layer of TRISO particles in a rotating drum in order to build up an overcoat layer of desired thickness. The matrix used in overcoating is a mixture of natural graphite, synthetic graphite, and thermosetting resin in the ratio, by weight, of 64:16:20. A wet mixing process was used for AGR-1 and AGR-2, in that the graphites and resin were mixed in the presence of ethyl alcohol. The goal of the wet mixing process was to 'resinate' the graphite particles, or coat each individual graphite particle with a thin layer of resin. This matrix production process was similar to the German, Chinese, Japanese, and South African methods, which also use various amount of solvent during mixing. See Appendix 1 for information on these countries matrix production techniques. The resin used for AGR-1 and AGR-2 was provided by Hexion, specifically Hexion grade Durite SC1008. Durite SC1008 is a solvated (liquid) resole phenolic resin. A resole resin does not typically have a hardening agent added. The major constituent of SC1008 is phenol, with minor amounts of formaldehyde. Durite SC1008 is high viscosity, so additional ethyl alcohol was added during matrix production in order to reduce its viscosity and enhance graphite particle resination. The current compacting scale up plan departs from a wet mixing process. The matrix production method specified in the scale up plan is a co-grinding jet mill process where powdered phenolic resin and graphite are all fed into a jet mill at the same time. Because of the change in matrix production style, SC1008 cannot be used in the jet milling process because it is a liquid. The jet milling/mixing process requires that a suite of solid or powdered resins be investigated. The synthetic graphite used in AGR-1 and AGR-2 was provided by SGL Carbon, grade KRB2000. KRB

  8. The migration of synthetic magnetic nanoparticle labeled dendritic cells into lymph nodes with optical imaging

    Directory of Open Access Journals (Sweden)

    Su H

    2013-10-01

    Full Text Available Hang Su,1,* Yongbin Mou,1,* Yanli An,2 Wei Han,1 Xiaofeng Huang,1 Guohua Xia,3 Yanhong Ni,1 Yu Zhang,4 Jianmin Ma,1 Qingang Hu1,5 1Center Laboratory of Stomatology, Stomatological Hospital Affiliated Medical School, Nanjing University, Nanjing, People's Republic of China; 2Jiangsu Key Lab of Molecular and Function Imaging, Department of Radiology; 3Department of Hematology, Zhongda Hospital, Medical School, 4State Key Laboratory of Molecule and Bimolecular Electronics, Jiangsu Provincial Laboratory for Biomaterials and Devices; Southeast University, Nanjing, People's Republic of China; 5Leeds Dental Institute, Faculty of Medicine and health, University of Leeds, Leeds, United Kingdom*These authors contributed equally to this workBackground: The successful biotherapy of carcinoma with dendritic cell (DC vaccines pivotally relies on DCs’ migratory capability into lymph tissues and activation of T cells. Accurate imaging and evaluation of DC migration in vivo have great significance during antitumor treatment with DC vaccine. We herein examined the behavior of DCs influenced by synthetic superparamagnetic iron oxide (SPIO nanoparticle labeling.Methods: γ-Fe2O3 nanoparticles were prepared and DCs, which were induced from bone marrow monocytes of enhanced green fluorescent protein (EGFP transgenic mice, were labeled. The endocytosis of the SPIO, surface molecules, cell apoptosis and fluorescence intensity of EGFP-DCs were displayed by Prussian blue staining and flow cytometry (FCM, respectively. After EGFP-DCs, labeled with SPIO, were injected into footpads (n = 5 for 24 hours, the mice were examined in vivo by optical imaging (OPI. Meanwhile, confocal imaging and FCM were applied, respectively, to detect the migration of labeled DCs into draining lymph nodes.Results: Nearly 100% of cells were labeled by the SPIO, in which the intracellular blue color gradually deepened and the iron contents rose with the increase of labeling iron concentrations

  9. X-ray Analysis of Defects and Anomalies in AGR-5/6/7 TRISO Particles

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-06-01

    Coated particle fuel batches J52O-16-93164, 93165, 93166, 93168, 93169, 93170, and 93172 were produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), or may be used for other tests. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.4%-enriched uranium carbide and uranium oxide (UCO), with the exception of Batch 93164, which used similar kernels from BWXT lot J52L-16-69316. The TRISO-coatings consisted of a ~50% dense carbon buffer layer with 100-μmnominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. Each coated particle batch was sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batch was designated by appending the letter A to the end of the batch number (e.g., 93164A). Secondary upgrading by sieving was performed on the upgraded batches to remove specific anomalies identified during analysis for Defective IPyC, and the upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93165B). Following this secondary upgrading, coated particle composite J52R-16-98005 was produced by BWXT as fuel for the AGR Program’s AGR-5/6/7 irradiation test in the INL ATR. This composite was comprised of coated particle fuel batches J52O-16-93165B, 93168B, 93169B, and 93170B.

  10. Correlation Relationship of Performance Shaping Factors (PSFs) for Human Reliability Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bheka, M. Khumalo; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2014-10-15

    between PSFs using correlation analysis and identify patterns in the PSFs using Principal Factor Analysis (PFA). The study is specifically based on Operational Performance Information Systems (OPIS) database. This study was conducted to determine causal relationships between PSFs and also find sets of PSFs (error forcing context) which contribute more to human error probabilities. These goals were achieved using correlation and principal factor analysis.

  11. Cleptomania: características clínicas e tratamento Kleptomania: clinical characteristics and treatment

    Directory of Open Access Journals (Sweden)

    Jon E Grant

    2008-05-01

    Full Text Available OBJETIVOS: A cleptomania, um transtorno incapacitante do controle dos impulsos, caracteriza-se pelo furto repetitivo e incontrolável de itens que são de pequena utilidade para a pessoa acometida por esse transtorno. Apesar de seu histórico relativamente longo, a cleptomania continua sendo pouco entendida pelo público geral, pelos clínicos e pelos que dela sofrem. MÉTODO: Este artigo revisa a literatura sobre o que se sabe a respeito das características clínicas, histórico familiar, neurobiologia e opções de tratamento para indivíduos com cleptomania. RESULTADOS: A cleptomania geralmente tem seu início no final da adolescência ou no início da vida adulta, e parece ser mais comum em mulheres. A comorbidade psiquiátrica ao longo da vida com outros transtornos de controle de impulsos (20-46%, de uso de substâncias (23-50% e de humor (45-100% é freqüente. Indivíduos com cleptomania sofrem de prejuízo significativo em sua capacidade de funcionamento social e ocupacional. A cleptomania pode responder ao tratamento com terapia cognitivo-comportamental e com várias farmacoterapias (lítio, antiepilépticos e antagonistas de opióides. CONCLUSÕES: A cleptomania é um transtorno incapacitante que resulta em uma vergonha intensa, bem como problemas legais, sociais, familiares e ocupacionais. São necessários estudos de tratamento em ampla escala.OBJECTIVES: Kleptomania, a disabling impulse control disorder, is characterized by the repetitive and uncontrollable theft of items that are of little use to the afflicted person. Despite its relatively long history, kleptomania remains poorly understood to the general public, clinicians, and sufferers. METHOD: This article reviews the literature for what is known about the clinical characteristics, family history, neurobiology, and treatment options for individuals with kleptomania. RESULTS: Kleptomania generally has its onset in late adolescence or early adulthood and appears to be more

  12. Gravity of injury and analgesia in patients who suffered traffic accidents Gravedad de la lesión y analgesia en pacientes que sufrieron accidentes de tránsito Gravidade da lesão e analgesia em pacientes que sofreram acidentes de transporte

    Directory of Open Access Journals (Sweden)

    Ana Maria Calil

    2008-01-01

    fueron de gravedad igual o menor a 3, indicativo de lesiones de gravedad leve, moderada y seria, localizadas principalmente en cuatro regiones corporales; en cuanto a la analgesia, la dipirona apareció como la droga más utilizada y se constató un reducido uso de opioides.OBJETIVOS: Identificar a freqüência e gravidade das lesões em acidentados de transporte e as drogas analgésicas utilizadas. MÉTODOS: Estudo retrospectivo, com amostra de 200 prontuários de pacientes internados no pronto-socorro de um Hospital referência para o atendimento ao trauma. A gravidade das lesões foram caracterizadas por índices de gravidade anatômicos e a terapêutica analgésica com base na Escada Analgésica da Organização Mundial de Saúde. RESULTADOS: Os principais achados apontaram as lesões em membros, cabeça, face e superfície externa como as mais freqüentes, e em 85% dos casos com gravidade menor ou igual que 3; quanto a analgesia verificou-se que 46,6% dos pacientes receberam dipirona e paracetamol , entre os opióides destacou-se a meperidina com 10,4%. CONCLUSÃO: A maioria das lesões foram de gravidade igual ou menor a 3, indicativo de lesões de gravidade leve, moderada e séria, localizadas principalmente em quatro regiões corpóreas; quanto à analgesia, a dipirona apareceu como a droga mais utilizada e constatou-se reduzido uso de opióides.

  13. Apnéia na sala de recuperação pós-anestésica: relato de caso Apnea en la sala de recuperación pós-anestésica: relato de caso Apnea in the postanesthetic recovery room: case report

    Directory of Open Access Journals (Sweden)

    Joel Massari Rezende

    2003-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A depressão respiratória é uma complicação que pode ocorrer no pós-operatório quando se utilizam opióides na anestesia. O objetivo deste relato é discutir um caso de apnéia em paciente que chegou consciente à sala de recuperação pós-anestésica (SRPA, após ter sido submetido à tireoidectomia sob anestesia geral com propofol, fentanil e isoflurano. RELATO DO CASO: Paciente do sexo feminino, 50 anos, 60 kg, estado físico ASA I, submetida à tireoidectomia sob anestesia geral induzida com propofol (140 mg, fentanil (350 µg, atracúrio (30 mg e mantida com isoflurano, duas doses subseqüentes em bolus de atracúrio (10 mg cada e ventilação controlada mecânica. No final da cirurgia, após antagonização do bloqueio neuromuscular, a paciente foi extubada, obedeceu aos comandos para respirar e colaborou na passagem à maca, sendo transportada para a SRPA, aonde chegou consciente. Minutos após, apresentou apnéia, cianose e inconsciência. Foi realizada ventilação manual com oxigênio a 100% seguida de injeção de naloxona (0,2 mg por via venosa, havendo retorno da ventilação espontânea e da consciência. CONCLUSÕES: Os cuidados ventilatórios no pós-operatório, durante o transporte, admissão à SRPA e permanência nessa unidade, devem ser contínuos em pacientes que receberam opióides, mesmo demonstrando estar conscientes ao deixarem a sala cirúrgica.JUSTIFICATIVA Y OBJETIVOS: La depresión respiratoria es una complicación que puede ocurrir en el pós-operatorio cuando se utilizan opioides en la anestesia. El objetivo de este relato es discutir un caso de apnea en paciente que llegó consciente a la sala de recuperación pós-anestésica (SRPA, después de haber sido sometido a tireoidectomia sobre anestesia general con propofol, fentanil e isoflurano. RELATO DE CASO: Paciente del sexo femenino, 50 años, 60 kg, estado físico ASA I, sometida a la tireoidectomia sobre anestesia general

  14. Transferência placentária de drogas Placental drug transfer

    Directory of Open Access Journals (Sweden)

    Ricardo de Carvalho Cavalli

    2006-09-01

    Full Text Available Grávidas podem depender do uso de medicações para minimizar os agravos da doença preexistente. A gravidez, por si só, pode causar situações que comprometem o bem-estar materno, como náuseas e vômitos, as quais necessitam de tratamento. O obstetra deve estar atento à transferência placentária de drogas e à exposição do feto a agentes teratogênicos ou tóxicos, que podem comprometer o seu desenvolvimento ou mesmo sua vida futura.O transporte através da placenta envolve o movimento de moléculas entre três compartimentos: sangue materno, citoplasma do sinciciotrofoblasto e sangue fetal. Esse movimento pode ocorrer pelos seguintes mecanismos: difusão simples, difusão facilitada, transporte ativo, bombas classe P, V, F e grande família ABC e endocitose. Com o uso de anticonvulsivantes a incidência de malformações maiores em recém-nascidos expostos é de 4 a 6%, comparado com 2 a 4% na população geral. A politerapia é mais lesiva, especialmente se o ácido valpróico e a hidantoína fazem parte da associação. Para as pacientes epilépticas clinicamente assintomáticas há dois anos recomenda-se a suspensão da drogas em uso, porém se apresentam crises, torna-se prudente consultar neurologista para discussão da terapia anticonvulsivante com melhores benefícios e menores efeitos colaterais. Os anestésicos locais e os opióides são largamente utilizados durante a resolução da gestação. A lidocaína utilizada como anestésico por via perineal para episiotomia, na dose fixa de 400 mg, apresenta alta concentração plasmática materna e alta taxa de transferência placentária no momento do nascimento, que vem alertar para o cuidado no uso de doses repetidas. A bupivacaína administrada por via epidural representa anestésico seguro, apresentando-se na forma racêmica e com transferência placentária em torno de 30%. A fentanila, anestésico opióide, utilizado por via epidural na resolução por cesariana, na dose

  15. Fetysz „obiektywności”. „Nasza klasa” Tadeusza Słobodzianka

    Directory of Open Access Journals (Sweden)

    Tomasz Żukowski

    2016-01-01

    completely ignored by the reviewers, however. They were also unable to break through the narration structures of the first type, which are more recognisable. Fetysz „obiektywności”. Nasza klasa Tadeusza Słobodzianka Nasza klasa przyjęta została w Polsce z entuzjazmem. Autora chwalono za odwagę, a jego głos uznano za wyważony i rozsądny w toczącej się od 2000 roku debacie nad zbrodnią w Jedwabnem. Skąd ten entuzjazm, którego brakowało przecież po publikacji Sąsiadów? Jakie zmiany wprowadzone przez Słobodzianka do narracji o Jedwabnem zapewniły mu sukces? Artykuł opisuje recepcję dramatu, która okazuje się wybiórcza. Sięga także do tekstu sztuki, wydobywając dwa porządki prezentowania i objaśniania zdarzeń. W pierwszej warstwie Nasza klasa tworzy obraz stosunków międzyludzkich, w którym znikają społeczne mechanizmy dyskryminacji. Wątek ten podchwytują i rozwijają polscy recenzenci. Wymordowanie Żydów okazuje się następstwem konfliktu równorzędnych grup z podobnymi możliwościami działania i sprawstwa, a więc nieuwikłanych w stosunki dominacji większości nad mniejszością. Stąd wynika symetria krzywd, a w konsekwencji nierozstrzygalność pytania o winę i domniemany tragizm aktorów zdarzeń. Do tego dochodzi psychologiczne wyjaśnianie zachowań i motywacji wzorowane na relacjach rodzinnych. Punkt widzenia uczestników wydarzeń (będący symptomem dyskryminacji zostaje potraktowany jako obiektywizujący opis. Widziane z bliska i psychologizowane perypetie bohaterów zasłaniają tło, jakim jest przemoc grupy dominującej. A tę można wyjaśnić jedynie w kategoriach socjologicznych. Słobodzianek sięga jednak także po opis na poziomie społecznym. Tak konstruuje scenę ślubu Rachelki, rozgrywanie sprawy jej ocalenia po wojnie – niezwykle opisany fenomen społecznego funkcjonowania motywu Sprawiedliwych – dostrzega i opisuje rytuały podporządkowania organizowane dla ocalałych oraz to, jak

  16. Sedação e analgesia em neonatologia Sedación y analgesia en neonatología Sedation and analgesia in neonatology

    Directory of Open Access Journals (Sweden)

    Yerkes Pereira e Silva

    2007-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A importância do estudo da dor em Neonatologia se deve ao fato de que a sensação de dor e estresse significa sofrimento e desconforto para os recém-nascidos e, apesar desse conhecimento, pouco tem sido feito para minimizá-los. Nessa revisão foram discutidas: a prevenção da dor, as medidas não-farmacológicas e farmacológicas para o seu tratamento e a sedação em recém-nascidos. CONTEÚDO: Várias são as medidas não-farmacológicas que podem ser tomadas com intuito de prevenir a dor nas Unidades de Terapia Intensiva Neonatal e também para tornar o ambiente mais humanizado e menos estressante para os pacientes e seus familiares. O tratamento da dor no recém-nascido consiste em medidas não-farmacológicas (sucção não-nutritiva, glicose e farmacológicas (analgésicos não-opióides, opióides e anestésicos locais. A sedação em recém-nascidos é produzida por fármacos que agem diminuindo a atividade, a ansiedade e a agitação do paciente, podendo levar à amnésia de eventos dolorosos ou não-dolorosos. A sedação pode ser feita pela administração de hidrato de cloral, barbitúricos, propofol e benzodiazepínicos. CONCLUSÕES: A prevenção da dor e a indicação de analgesia devem ser individualizadas e sempre consideradas em todos os recém-nascidos portadores de doenças potencialmente dolorosas e/ou submetidos a procedimentos invasivos, cirúrgicos ou não.JUSTIFICATIVA Y OBJETIVOS: La importancia del estudio del dolor en neonatología se debe al hecho de que la sensación de dolor y de estrés significa sufrimiento e incomodidad para los recién nacidos y, a pesar de ese conocimiento poco se ha hecho para reducirlo. Dentro de esa revisión se discutieron: la prevención del dolor, las medidas no farmacológicas ye farmacológicas para su tratamiento y la sedación en recién nacidos. CONTENIDO: Varias son las medidas no-farmacológicas que pueden ser tomadas con el objetivo de prevenir el

  17. Remifentanil: o regime de infusão faz diferença na prevenção das respostas circulatórias à intubação traqueal? Remifentanil: ¿el régimen de infusión es la diferencia en la prevención de las respuestas circulatorias a la intubación traqueal? Remifentanil: does the infusion regimen make a difference in the prevention of hemodynamic responses to tracheal intubation?

    Directory of Open Access Journals (Sweden)

    Fernando Squeff Nora

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os opióides em doses elevadas diminuem a resposta circulatória à intubação traqueal. Entretanto, o lento perfil de recuperação dos opióides tradicionais pode limitar a utilização em altas doses. O remifentanil possui tempo de início e de término de ação rápidos e previsíveis, o que o diferencia dos demais. O objetivo primário deste estudo foi verificar a hipótese de que não há necessidade de iniciar a administração de remifentanil antes da indução com o propofol. MÉTODO: Foram avaliados 30 pacientes, divididos em dois grupos, que receberam anestesia geral venosa total. No Grupo 1, a infusão de remifentanil (0,3 µg.kg-1.min-1 foi iniciada dois minutos antes da indução e, no Grupo 2, juntamente com a indução. Foram avaliadas as pressões arteriais sistólica, diastólica e média (PAS, PAD, PAM, freqüência cardíaca (FC, concentrações no local efetor de propofol (CEF-prop e de remifentanil (CEF-remi em três momentos: basal (M0; após a perda do contato verbal (M1; e após a intubação traqueal (M2. RESULTADOS: As pressões arteriais apresentaram reduções significativas em ambos os grupos, em M1 e M2. A CEF-remi foi maior no Grupo 1, em M1 e maior, no Grupo 2, em M2 (p JUSTIFICATIVA Y OBJETIVOS: Los opioides en dosis elevadas disminuyen la respuesta circulatoria a la intubación traqueal. Sin embargo, el lento perfil de recuperación de los opioides tradicionales puede limitar la utilización en altas dosis. El remifentanil posee tiempo de inicio y de término de acción rápidos y previsibles, lo que lo diferencia de los demás. El objetivo primario de este estudio fue verificar la hipótesis de que no hay necesidad de iniciar la administración de remifentanil antes de la inducción con el propofol. MÉTODO: Fueron evaluados 30 pacientes, divididos en dos grupos, que recibieron anestesia general intravenosa total. En el Grupo 1, la infusión de remifentanil (0,3 µg.kg-1.min-1 se

  18. Eficacia y tolerabilidad de esteroides epidurales vs. Dosis bajas de esteroides mas metamizol mas D-propoxifeno administrados por vía paravertebral en pacientes con síndrome post-laminectomía Efficacy and tolerability of epidural steroids vs low doses of steroids plus metamizol plus propoxyphene administered paravertebrally for postaminectomy syndrome patients

    Directory of Open Access Journals (Sweden)

    J. A. Aldrete

    2006-10-01

    Full Text Available El reconocimiento de la acción antinociceptiva de los antiinflamatorios no esteroideos (AINEs ha motivado su combinación con dosis moderadas de opiáceos con objeto de obtener una mayor analgesia, mientras que se reduce la necesidad de emplear dosis altas de esteroides. Un grupo de 142 pacientes adultos, que habían desarrollaron radiculopatía y lumbalgia después de la primera discectomia, en los que se demostró radiologicamente fibrosis y cicatriz periradicular, en el sitio de operación, se dividieron en dos subgrupos al azar. El grupo A (69 pacientes, fue tratado con inyecciones peridurales de 80 mg de metilprednisolona (MTP en 3ml de bupivacaína 0.25% (BPV después de obtener medidas controles de dolor, actividad física y la ingestión de medicamentos usando el Esquema del Progreso del Dolor, obteniendo un promedio control antes de iniciar el tratamiento. El grupo B (73 pacientes fue tratado con inyecciones paravertebrales en los niveles L4-L5 y L5-S1, de 5 mg de metamizol (DPN, y 12.5 mg de propoxifeno (PPX agregados a 10 mg de MTP y 1 ml de BPV 0.5%, bilateralmente en cuatro sesiones. Las mismas evaluaciones se llevaron a cabo cada 3 semanas después de cada tratamiento. Todos los pacientes mejoraron clínicamente, sin observarse diferencias significativas entre ambos grupos; Cuando se compararon los valores totales de mejoría clínica, se observaron los niveles controles significativos (p> 0.05 solo cuando se compararon con las mediciones de mejoría clínica, tomadas antes de iniciar el tratamiento en ambos grupos. Se presentaron efectos secundarios como incremento de peso, equimosis, edema fascies lunar y eritema facial en los pacientes del grupo A. La punción dural incidental (3 y cefalea por punción dural (2 se encontraron solo en el grupo A. Un paciente requirió ser tratado con un parche hematico epidural. Ocurrió parestesia en 1 paciente de cada grupo. No se encontraron diferencias significativas de mejoria entre grupos

  19. Las Farmacodependencias

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    José Francisco Socarrás

    1994-09-01

    Full Text Available

    Ahora, cuando la Corte Constitucional ha despenalizado al farmacodependiente por el consumo de drogas, conviene informar sobre las consecuencias perjudiciales de estas. A quienes deseen un conocimiento detallado al respecto, les recomiendo documentarse en “Enciclopedia de Psiquiatría”, publicada por “El Ateneo” en Buenos Aires.

    El Capítulo respectivo es del doctor Daniel L. Murguia. El denominador corriente de su abuso es sencillamente la dependencia, nombre propuesto por la Organización Mundial de la Salud, definido como el “estado psíquico y a veces físico causado por la interacción entre un organismo vivo y un fármaco”. Su carácter esencial es el impulso psicofísico a consumir el producto en forma continua o periódica, con el fin de experimentar los efectos que acarrea y evitar los malestares de su privación. Todas las drogas del respectivo género, consumidas a dosis altas, tienen efectos psicotóxicos que alteran la conducta y en algunos casos conducen a la muerte.

    Los expertos de la Organización Mundial califican las mencionadas sustancias en seis grupos, a saber:

    1. Morfina y opiáceas, los cuales crean dependencia física y psicológica, con tolerancia precoz, necesidad de aumentar las dosis y síndrome de abstinencia bastante peligroso. Entre los derivados se cuentan los siguientes: Hidromorfina (Dilaudid; oximorfina (Nurmophan; heroína,
    éter diacético de la morfina (Diacetilmorfina; codeína (Metilmorfina; hidrocodeína (Hicadan’ oxicodeína (Perdocan. Los efectos de los opiáceo~ son los siguientes: analgesia, depresión respiratoria y espasmo gastrointestinal. Las dosis tóxicas pueden provocar convulsiones.

    2. Barbitúricos, alcohol y sedantes como el fenobarbital, que provocan así mismo dependencia física.

    3. Anfetaminas, en particular la Bencedrina inhalante, que acarrea dependencia psicológica.

    4. Cocaína, cuya dependencia psíquica es tal que muchos

  20. Anestesia venosa total em regime de infusão alvo-controlada: uma análise evolutiva Anestesia venosa total en régimen de infusión objeto controlada: un análisis evolutivo Total intravenous anesthesia as a target-controlled infusion: an evolutive analysis

    Directory of Open Access Journals (Sweden)

    Fernando Squeff Nora

    2008-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A anestesia venosa total (AVT sofreu diversos avanços desde o início da utilização da técnica. Desde a síntese dos primeiros anestésicos venosos, com a introdução dos barbitúricos (1921 e do tiopental (1934, a AVT evoluiu até o desenvolvimento da AVT com auxílio de bombas com infusão alvo-controlada (IAC. O primeiro modelo farmacocinético para uso em IAC foi descrito por Schwilden em 1981. Foi demonstrado, a partir daí, que era possível manter a concentração plasmática desejada de um fármaco utilizando-se bomba de infusão gerenciada por computador. CONTEÚDO: Este artigo visou a descrever as bases teóricas da IAC, a apresentar uma proposta de desenvolvimento de um vocabulário comum em IAC ainda não publicado no Brasil e a fazer uma análise crítica dos aspectos atuais da IAC no mundo e no Brasil. CONCLUSÕES: A chegada de novas bombas de infusão dotadas dos modelos farmacocinéticos do remifentanil, sufentanil e propofol inaugura outro capítulo da AVT e alinha o Brasil com a tendência mundial em IAC. Esses sistemas possibilitarão a IAC de hipnóticos e opióides concomitantemente. A conclusão mais importante, no entanto, refere-se à economia à medida que os fármacos utilizados nessas bombas não ficarão restritos apenas a uma empresa farmacêutica, a exemplo do que ocorreu com o propofol. Hoje já se dispõe de equipamentos para utilização de propofol e opióides, em IAC, que aceitam qualquer apresentação farmacêutica com a vantagem da possibilidade de alteração da concentração do fármaco na seringa, de acordo com a diluição desejada.JUSTIFICATIVA Y OBJETIVOS: La anestesia venosa total (AVT tuvo diversos avances desde el inicio de la utilización de la técnica. Desde la síntesis de los primeros anestésicos venosos, con la introducción de los barbitúricos (1921 y del tiopental (1934, la AVT evolucionó hasta el desarrollo de la AVT con el auxilio de bombas con infusi

  1. Recomendaciones de prevención y tratamiento de las náuseas y vómitos postoperatorios y/o asociados a las infusiones de opioides Recommendations for the prevention and treatment of postoperative and/or opioid infusion-related nausea and vomiting

    Directory of Open Access Journals (Sweden)

    J. I. Gómez-Arnau

    2011-02-01

    Full Text Available Las náuseas y los vómitos postoperatorios (NVPO producen malestar e insatisfacción del paciente y aumentan la necesidad de cuidados. La infusión de opiáceos, frecuente como tratamiento analgésico postoperatorio, puede inducir náuseas y/o vómitos (NV. Este trabajo tiene como objetivo el desarrollo de recomendaciones de prevención y tratamiento de ambos problemas. Con este fin se constituyó un Grupo de Trabajo de acuerdo con los estatutos de la Sociedad Española de Anestesiología y Reanimación. Dicho grupo realizó una evaluación crítica de artículos relevantes sobre el manejo de las NV perioperatorios precoces y tardíos tanto en adultos como en niños. Tras varias reuniones y discusión se acordaron las siguientes recomendaciones (resumen: 1. Todos los pacientes sometidos a cirugía deben ser evaluados respecto al riesgo de desarrollar NVPO. Se recomiendan las escalas de Apfel et al. para adultos y de Eberhart et al. para niños, ambas son útiles y fáciles de aplicar; 2. En los adultos con riesgo moderado o alto y en todos los niños se deben adoptar medidas de reducción del riesgo basal; 3. La profilaxis con un fármaco es útil en pacientes de riesgo bajo (Apfel 1 o Eberhart 1 sometidos a anestesia general. En los demás pacientes se debe realizar profilaxis con 2 o más fármacos y reducir el riesgo basal (abordaje multimodal; 4. Dexametasona, droperidol y ondansetrón (setrones en general tienen similar eficacia. La elección de fármaco debe tener en consideración factores individuales en cada paciente; 5. El tratamiento de las NVPO establecidas debe hacerse preferentemente con un fármaco diferente al empleado en la profilaxis. El fármaco más efectivo es el ondansetrón; 6. Debe evaluarse la posibilidad de NVPO tras el alta del paciente en cirugía ambulatoria o en la sala de hospitalización en cirugía con ingreso. No existen evidencias suficientes para formular una estrategia de prevención de las NV tardíos; 7

  2. Bostezo y epilepsia del lóbulo temporal Yawning and temporal lobe epilepsy

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    S. Muchnik

    2003-04-01

    Full Text Available La epilepsia del lóbulo temporal, es aquella epilepsia parcial donde las estructuras temporales límbicas son las responsables de los principales síntomas ictales. Se caracteriza por la recurrencia de crisis parciales simples y complejas con confusión post-ictal y amnesia del evento. El efecto facilitador del sueño No REM en la propagación de las crisis, como las anormalidades del sueño provocadas por la epilepsia del lóbulo temporal, son evidenciadas claramente en nuestros pacientes. El bostezo es un reflejo fisiológico, principalmente inducido por el despertar y el adormecimiento, puede estar asociado a diferentes enfermedades neurológicas. Su relación con la epilepsia de origen límbico, ha sido escasamente mencionada. Describimos en un paciente, un episodio de bostezos y crisis parcial compleja mientras dormitaba. El EEG mostró actividad irritativa focal, independiente y bilateral en regiones temporales medias. Tratado con carbamazepina 400mg/d, no repitió el episodio. Otro paciente presentó crisis parciales complejas secundariamente generalizadas con episodios de bostezos en el período post-ictal, luego de las siestas. El EEG fue normal y la polisomnografía nocturna mostró actividad irritativa sincrónica y bilateral en regiones temporales medias con generalización secundaria. Tratado con divalproato de sodio 750 mg/d, no se registraron nuevos episodios. La epilepsia del lóbulo temporal, el ciclo sueño-vigilia y el bostezo, parecen compartir no solamente las mismas estructuras anatómicas, sino también los mismos mecanismos neuroquímicos. El hecho de que los opiáceos endógenos sean considerados como parte de un sistema protector que inhibe y previene las crisis, permite postular que el bostezo sería la expresión de los mecanismos inducidos por los opiáceos endógenos que inhiben y previenen las crisis de la epilepsia del lóbulo temporal. Otro punto de vista sería presentar al bostezo simplemente como una forma

  3. Treg 细胞及 FOxP3在子宫内膜异位症患者的表达及临床意义%The expression and clinical significance of Treg cells and transcription factor Foxp3 in patients with endometriosis

    Institute of Scientific and Technical Information of China (English)

    李素红; 冯春蝶; 付秀虹

    2014-01-01

    目的:观察调节性 T 细胞(regulatOry T cells,Treg cells)在子宫内膜异位症(endOmetriOsis, EMT)患者外周血中的频率及转录因子 FOxP3在异位内膜、在位内膜和正常内膜组织中的表达,旨在探讨 Treg细胞及 FOxP3与 EMT 的关系。方法选取35例 EMT 患者作为研究组,15例因畸胎瘤行手术的患者为对照组,采集两组患者的外周血,应用流式细胞技术检测两组外周血中 Treg 细胞的频率;留取35例 EMT 患者的异位内膜组织,20例 EMT 患者中因不孕或月经异常行宫腔镜检查术者的在位内膜组织,15例因妇科良性疾病行宫腔镜检查术者的正常内膜组织,采用免疫组化法检测比较异位内膜、在位内膜及正常内膜组织中 FOxP3的表达。结果 Treg 细胞在 EMT 患者外周血中的频率显著低于对照组(P <0.05);转录因子 FOxP3在异位内膜组织中表达的阳性率显著高于在位内膜及正常内膜组织(P <0.05)。结论 Treg 细胞频率在 EMT 患者外周血中显著下降,在异位内膜组织中显著升高,Treg 细胞分布失衡与 EMT 的发病关系密切。%Objective TO Observe the frequency Of regulatOry T(Treg)cells in PeriPheral blOOd Of Patients with endOmetriOsis(EMT)and the exPressiOn Of transcriPtiOn factOr FOxP3 in ectOPic endOmetrium,eutOPic endOmetrium and nOrmal endOmetrium tissues,tO exPlOre the relatiOnshiP between Treg cells,FOxP3 and EMT. Methods 35 EMT cases and 15 cases with teratOma were selected as study grOuP and cOntrOl grOuP seParately,the PeriPheral blOOd Of twO grOuPs were cOllected,the frequency Of Treg cells in PeriPheral blOOd were detected by flOw cytOmetry technique;EctOPic endOmetrium tissues Of 35 ETM cases were extracted,eutOPic endOmetrium Of 20 Patients cOnducted hysterOscOPy examinatiOn fOr infertility Or menstrual abnOrmalities were extracted,nOrmal endOmetrium tissues Of 15 cases cOnducted hysterOscOPy examinatiOn fOr benign gynec

  4. Otkaz hidrauličkog sistema čekića kao posledica kontaminacije čvrstim česticama

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    Mitar T. Jocanović

    2014-02-01

    Full Text Available Hidraulični sistemi mobilnih mašina su često kontaminirani čvrstim česticama. Čvrste čestice povećavaju intenzitet abrazivnog habanja hidrauličnih komponenata, i čine jednim od glavnih uzročnika otkaza sistema. U radu je dat prikaz reprezentativnog primera uticaja čvrstih čestica na povećano habanje delova hidrauličnog čekića bagera u eksploatacionim uslovima bagera u cementnoj industriji. Uvod Kontaminacija radnog fluida hidrauličnog sistema, jedan je od najvećih neprijatelja mobilnih mašina. Na mobilnim mašinama, koje se obično koriste u kontaminiranoj sredini, potrebno je pravilnim projektovanjem zaštititi hidraulični sistem posebno od eksterne kontaminacije. Uticaj kontaminanata na rad i pouzdanost hidrauličnih komponenata, a time i hidrauličnih sistema, može značajno da smanji planirani eksploatacioni vek. U radu je dat prikaz uticaja kontaminacije radnog fluida hidrauličnog sistema bagera preko radnog dela, hidrauličnog čekića. Uočeno je da zbog loše konstrukcije čekića i nepravilnog izbora povratnog filtera u hidrauličnom sistemu bagera,  u toku rada dolazi do prodora kontaminanata u vidu čvrstih čestica koje dovode do povećanja habanja radnih delova hidrauličnih komponenata (prvenstveno pogonske hidraulične pumpe kao i radnih delova hidrauličnog čekića. Da bi se shvatio uticaj kontaminacije hidrauličnog ulja čvrstim česticama, u radu je priložena foto-dokumentacija kritičnih delova pojedinih komponenti koje su oštećene. Takođe, izvršena je ekonomska analiza koja ukazuje na potrebu da se na mobilnim mašinama izvrši adekvatno filtriranje hidrauličnog fluida. Opis rada hidrauličnog sistema čekića Dat je opis jednog radnog ciklusa hidrauličnog čekića. Radni proces izazivanja udaraca čekićem zahteva kontinualno ponavljanje prethodno opisanog ciklusa. Iz navedenog se vidi da je rad hidrauličnog čekića veoma dinamičan ciklus kretanja određenih delova čekića, koji da bi

  5. Anormalidades de fluxo sangüíneo cerebral em indivíduos dependentes de cocaína Cerebral blood flow abnormalities in cocaine dependent subjects

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    Sergio Nicastri

    2000-06-01

    Full Text Available INTRODUÇÃO: Nos últimos anos, tem havido relatos de anormalidades do fluxo sanguíneo cerebral em indivíduos com o abuso de cocaína, detectadas por meio de tomografia computadorizada por emissão de fóton único (SPECT. Esse padrão anormal de perfusão cerebral tem sido associado a prejuízos cognitivos mas não a alterações observáveis por meio de exames de neuroimagem estrutural. Um problema envolvendo a maioria dos trabalhos publicados sobre esse tema é a inclusão de um grande número de usuários de heroína nas amostras estudadas. Essa outra droga também parece afetar o padrão de perfusão cerebral, particularmente durante estados de abstinência. MÉTODOS: Quatorze pacientes dependentes de cocaína (nenhum com uso de opióides e 14 voluntários normais (grupo controle foram submetidos a exames de SPECT com dímero de etil-cisteína marcado com tecnécio-99m. A análise dos exames de SPECT foi realizada por meio de análise visual qualitativa das imagens obtidas (procedimento padrão na prática clínica, realizada por um radiologista não informado sobre o diagnóstico dos indivíduos avaliados. RESULTADOS: A análise visual revelou um padrão sugestivo de irregularidades do fluxo sangüíneo cerebral em nove pacientes, mas em apenas dois controles (p = 0,018; teste exato de Fisher bicaudal. CONCLUSÕES: Anormalidades de circulação cerebral podem ter relação com prejuízos cognitivos relatados em populações de dependentes de cocaína. Embora déficits de perfusão cerebral associados ao uso de cocaína possam ser irreversíveis, têm surgido relatos na literatura de tratamentos para essas anormalidades de fluxo sangüíneo. Alterações de fluxo sangüíneo cerebral associadas à dependência de cocaína ocorrem mesmo na ausência de abuso ou dependência de opióides.INTRODUCTION: In the last years, there have been reports of abnormalities in brain blood flow of cocaine abusers, detected by single photon computed

  6. Lesión de la médula espinal: actualización bibliográfica: fisiopatología y tratamiento inicial Lesão de medula espinal: atualização da literatura: fisiopatologia e tratamento inicial Spinal cord injury: literature update: physiopathology and initial treatment

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    Vicente Ballesteros Plaza

    2012-01-01

    Full Text Available La fisiopatología del trauma raquimedular (TRM es compleja y aún no se conoce completamente. La lesión al cordón espinal está determinada por procesos primarios y secundarios. La lesión primaria se debe a la transmisión de energía mecánica a la médula y las estructuras neurales durante el evento traumático. La lesión secundaria, que compromete estructuras que habían permanecido indemnes después del trauma inicial, desencadena alteraciones en: la perfusión microvascular, la liberación de radicales libres y de neurotransmisores, la peroxidación lipídica, la concentración iónica y la consecuente muerte celular tanto por necrosis como por apoptosis. La investigación en el tratamiento del TRM, basada en el conocimiento actual de estos mecanismos de lesión, ha buscado el desarrollo de intervenciones terapéuticas tempranas que atenúen el efecto de estos mecanismos fisiopatológicos secundarios, tanto en el sitio del accidente, como después del ingreso a un centro de trauma. Dentro de la intervención farmacológica se ha descrito, por su teórico efecto protector en el pronóstico neurológico de los pacientes con TRM, el uso de metil-prednisolona, gangliósidos y medicamentos antagonistas de los opiáceos, del receptor de glutamato y de los canales iónicos. Sin embargo, aún no se ha identificado ninguna intervención que modifique este pronóstico en forma significativa.A fisiopatologia da lesão de medula espinal (LME é complexa e não está completamente esclarecida. A LME é determinada por processos primários e secundários. A lesão inicial é produzida pela transmissão de energia mecânica para a medula espinal e as estruturas neurais. A lesão secundária atua sobre as estruturas que são poupadas pelo trauma inicial, afetando a perfusão microvascular e as concentrações iônicas, desencadeando a liberação de radicais livres e neurotransmissores e ativando a peroxidação lipídica, o que produz a morte celular

  7. Conocimientos y actitudes de pacientes y personal sanitario frente al dolor postoperatorio Patients´and health professionals´knowledge and attitudes towards postoperative pain

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    D. L. Fernández-Galinski

    2007-01-01

    Full Text Available Introducción: La falta de actualización del personal sanitario en el tema del dolor postoperatorio perpetúa conceptos y conductas erróneas que perjudican la recuperación de los pacientes. En el contexto de la creación de una Unidad de Dolor Agudo y previamente al desarrollo de un plan de formación, se diseñó el presente estudio para conocer el nivel de conocimientos y las actitudes de pacientes y personal sanitario en relación al dolor postoperatorio. Material y método: Estudio realizado en un hospital de 765 camas (240 quirúrgicas. Se distribuyeron 100 cuestionarios a pacientes mayores de 18 años tributarios de intervención quirúrgica programada, con preguntas referidas al dolor postoperatorio en sus antecedentes quirúrgicos y las expectativas ante la próxima operación. Se repartieron 100 cuestionarios entre enfermería de hospitalización, indagando sobre el conocimiento de diferentes técnicas analgésicas y actitudes respecto al manejo de opiáceos. El personal médico quirúrgico que recibió 65 cuestionarios fue consultado acerca de las complicaciones y tratamiento del dolor postoperatorio. Resultados: El 79% (IC 95%: 68-87 de los pacientes entrevistados había sido operado anteriormente. El 39% (IC 95%: 27-51 de los mismos recordaba haber sentido dolor en el postoperatorio y de ellos el 46 % catalogaba al dolor como moderado - intenso. En relación a la futura intervención quirúrgica, el 65% (IC 95%:54-75 prefería que se le administrase morfina antes de padecer dolor. En el ámbito de la enfermería, el 18% (IC 95%: 10-27 y el 10% (IC 95%: 4-17 del personal desconocía el manejo de opiáceos por vía intramuscular y vía intravenosa respectivamente. El tratamiento del dolor con anestésicos locales por vía peridural era desconocido para el 23% (IC 95%: 4-33. Para el 46% (IC 95%:35-57 de la enfermería encuestada, el temor a los efectos indeseables de los mórficos, condicionaba su administración. Sólo el 53% (IC 95

  8. Estudo comparativo da eficácia analgésica pós-operatória de 20, 30 ou 40 mL de ropivacaína no bloqueio de plexo braquial pela via posterior Estudio comparativo de la eficacia analgésica postoperatoria de 20, 30 o 40 mL de ropivacaína en el bloqueo de plexo braquial por la vía posterior A comparative study on the postoperative analgesic efficacy of 20, 30, or 40 mL of ropivacaine in posterior brachial plexus block

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    Marcos Guilherme Cunha Cruvinel

    2007-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As intervenções cirúrgicas por via artroscópica no ombro estão relacionadas com a dor pós-operatória de grande intensidade. Dentre as técnicas de analgesia, o bloqueio do plexo braquial é a que oferece os melhores resultados. O objetivo deste estudo foi determinar qual volume de anestésico local no bloqueio de plexo braquial pela via posterior propicia analgesia pós-operatória para essas operações de maneira mais eficiente. MÉTODO: Noventa pacientes submetidos a bloqueio do plexo braquial pela via posterior foram divididos aleatoriamente em três grupos de 30. Grupo 1 - volume de 20 mL; Grupo 2 - volume de 30 mL; e Grupo 3 - volume de 40 mL. Em todos os grupos, o anestésico usado foi a ropivacaína a 0,375%. O bloqueio foi avaliado por meio da pesquisa de sensibilidade térmica utilizando-se algodão embebido em álcool e a dor pós-operatória foi avaliada seguindo-se uma escala numérica verbal (ENV nas primeiras 24 horas. RESULTADOS: Nos três grupos a analgesia pós-operatória foi similar segundo os parâmetros avaliados; ENV de dor média, tempo até a primeira queixa de dor e consumo de opióides no pós-operatório. No grupo de 20 mL houve um maior consumo de analgésicos não-opióides após a 12ª hora de pós-operatório. Nos grupos de 30 e 40 mL a extensão do bloqueio foi muito maior. CONCLUSÕES: Este estudo mostrou que o bloqueio do plexo braquial pela via posterior é uma técnica que promove analgesia eficaz para intervenções cirúrgicas no ombro. Os três diferentes volumes estudados promoveram analgesia similar. A maior extensão do bloqueio com volumes maiores não se traduziu em melhor analgesia.JUSTIFICATIVA Y OBJETIVOS: Las intervenciones quirúrgicas por vía artroscópica en hombro están relacionadas al dolor postoperatorio de gran intensidad. Entre las técnicas de analgesia, el bloqueo del plexo braquial es el que ofrece los mejores resultados. El objetivo de este estudio

  9. Sedação e analgesia em crianças: uma abordagem prática para as situações mais freqüentes Analgesia and sedation in children: practical approach for the most frequent situations

    Directory of Open Access Journals (Sweden)

    Santiago Mencía Bartolomé

    2007-05-01

    Full Text Available OBJETIVOS: Revisar as indicações, doses e formas de administração dos sedativos, analgésicos e relaxantes musculares mais utilizados na criança, bem como os métodos de monitorização da sedação. FONTES DOS DADOS: Levantamento bibliográfico utilizando a base de dados MEDLINE e revisão da experiência em nossas unidades de cuidados intensivos pediátricos. SÍNTESE DOS DADOS: A administração contínua de drogas analgésicas e sedativas impede o aparecimento das fases de subsedação e requer menor assistência do que na administração intermitente. O midazolan é a droga mais utilizada para sedação contínua da criança gravemente enferma. Os derivados opiáceos e os antiinflamatórios não-hormonais são os analgésicos mais utilizados na criança gravemente enferma. Os opióides associados aos benzodiazepínicos em infusão contínua são os fármacos de eleição em crianças em ventilação mecânica, especialmente a morfina e o fentanil. O uso de protocolos e a monitorização com a utilização de escores clínicos e métodos objetivos como o BIS permitem ajustar mais corretamente a medicação, evitando a supersedação, a subsedação e a síndrome de abstinência. As intervenções não-farmacológicas, como a musicoterapia, o controle de ruídos, a adequada utilização da luz, a massagem e a comunicação com o paciente, são medidas complementares que auxiliam na adaptação da criança ao ambiente hospitalar adverso. CONCLUSÕES: A sedação deve ser adaptada a cada criança em cada momento. O emprego de protocolos que facilitem uma correta seleção de fármacos, uma administração adequada e uma monitorização cuidadosa melhoram a qualidade da sedoanalgesia e reduzem seus efeitos adversos.OBJECTIVES: To review the most frequent recommendations, doses and routes of administration of sedatives, analgesics, and muscle relaxants in children, as well as the methods for monitoring the level of sedation. SOURCES: Review

  10. Efeitos adversos do sufentanil associado ao anestésico local pelas vias subaracnóidea e peridural em pacientes submetidas à analgesia de parto Efectos adversos del sufentanil asociado al anestésico local por las vías subaracnoidea y peridural en pacientes sometidas a la analgesia de parto Side effects of subarachnoid and epidural sufentanil associated with a local anesthetic in patients undergoing labor analgesia

    Directory of Open Access Journals (Sweden)

    Isabel C.F. Salem

    2007-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A associação do opióide ao anestésico local melhora a qualidade da analgesia de parto e reduz o risco de toxicidade sistêmica pelo anestésico local. Os opióides, entretanto, podem determinar efeitos colaterais. O objetivo desta pesquisa foi comparar os efeitos adversos determinados pelo sufentanil, administrado por via subaracnóidea, associado à bupivacaína, com aquele determinado pelo sufentanil por via peridural, associado à ropivacaína, nas doses utilizadas no Serviço de Anestesia, em gestantes submetidas à analgesia de parto. MÉTODO: Participaram do estudo 60 pacientes, estado físico ASA I e II, com idade entre 15 e 42 anos, com gestação a termo e fetos saudáveis, submetidas à analgesia de parto. Foram distribuídas de forma aleatória em dois grupos: G1 - Duplo bloqueio - bupivacaína a 0,5% (2,5 mg e sufentanil (5 µg pela via subaracnóidea, G2 - Peridural - ropivacaína a 0,2% (20 mg e sufentanil (10 µg pela via peridural. Para doses complementares foi administrada ropivacaína a 0,2% (12 mg e para resolução do parto, ropivacaína a 1% (50 mg. As pacientes foram avaliadas após analgesia (M1 com relação a hipotensão arterial, bradicardia materna, prurido, náusea, vômito, depressão respiratória e sedação. No pós-operatório (M2, quanto à presença de náusea, vômito, prurido, sedação, retenção urinária e dor. Os recém-nascidos foram avaliados pelo índice de Apgar. Para análise estatística, foram utilizados teste t de Student, Mann-Whitney e Qui-quadrado. RESULTADOS: Os grupos foram similares com relação à idade, ao peso, à altura, à duração do período de trabalho de parto após analgesia, ao Apgar dos recém-nascidos, à ocorrência de hipotensão arterial, bradicardia, náusea, vômito, prurido e retenção urinária. A sedação foi mais freqüente nas pacientes de G2, em M1 (50% com diferença estatística significativa. CONCLUSÕES: O sufentanil nas doses

  11. 中药镇痛机理研究概述%Research on Analgesia Mechanism of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    陆怡; 朱元章; 朱国福; 潘颖宜

    2015-01-01

    目的:对中药的镇痛机理研究进行综述。方法:查阅近5年的国内外文献,对中药在中枢和外周神经系统中调节β-内啡肽(β-EP)、5-羟色胺(5-HT)、前列腺素 E2(PGE2)、一氧化氮(NO)等的作用进行归纳、分析、总结。结果:通过中枢神经系统发挥镇痛作用的途径主要包括增加阿片肽类的含量、抑制第二信使神经递质 NO 的释放、降低脑组织中 PGE2的含量以及提高中枢5-HT 的含量等;通过外周神经系统发挥镇痛作用的途径主要包括减少外周致痛物质、减轻局部致痛物质的堆积、增加外周内源镇痛物质的释放以及调节原癌基因(c-fos)等。结论:应进一步加强对中药镇痛机制的研究,为镇痛中药的进一步开发利用提供参考。%Objective:To review the analgesic mechanism of Chinese medicine.Methods:The regulation of beta-endorphin(β-EP),5-hydroxytryptamine (5-HT),prostaglandin2 (PGE2 ),nitric oxide (NO)and so on in central nervous system and peripheral nervous system were analyzed and concluded based on the recent five years’studies from home and abroad.Results:Analgesic effect played through the central nervous system was effected by increasing the content of endogenous analgesic substances like opi-oid peptide,cutting down the second messenger of neurotransmitter like NO,reducing the content of PGE2 in brain tissue and rai-sing the content of the central 5-HT;analgesic effect played through the peripheral nervous system was effected by reducing the pe-ripheral algogenic substance and inducing pain caused by the secretion of pain,inducing the accumulation of part algogenic sub-stance,increasing the releasing peripheral endogenous analgesia material and adjusting the c-fos gene.Conclusion:Basic research should be conducted to do further study.

  12. Assessment of TVOC and Odor in the Remediation Site of Contaminated Soil and Groundwater Using Electronic Nose%基于电子鼻土壤与地下水污染修复现场TVOC和恶臭的评估

    Institute of Scientific and Technical Information of China (English)

    田秀英; 蔡强; 刘锐; 张永明

    2013-01-01

    According to the conditions of a contaminated soil and groundwater remediation site in Shanghai, the self-built electronic nose was applied to detect VOCs and odor of previously remedied soil and groundwater, remedying soil and groundwater, and the air above and around the site. Combining the formula of TPI and OPI, the value of each point was got and was shown in figures. Results showed:① Comparing the determination results of previously remedied with remedying contaminated soil and groundwater, the concentration of TVOC and odor was overall declined. The result was consistent with the fact. The detection result of electronic nose was proved to be right; ② In the remediation process of soil and groundwater, the volatilization of VOCs and odor was inflected by temperature and works of crushing, adding medicine and turning the soil on time. The concentration showed a trend of overall decline with stage rising, so the electronic noses can be used for dynamic monitoring of the whole remediation process; ③ Combined with the GIS, the electronic noses can preliminary assess space pollution situation caused by the remediation of contaminated soil and groundwater and the influence on the residence in the surrounding region. However, further study on the refined classification of the impact degree is needed.%根据上海某土壤与地下水污染修复现场情况,应用自主研发的电子鼻系统(iSA-M1)分别对未修复及修复过程中的土壤和地下水、修复场地上空及周边空气中的VOCs和恶臭类气体进行检测.结合前期研究所得TPI和OPI公式,求得各点的值,并将其用图表示.结果表明:①修复后TVOC和恶臭的浓度总体呈下降趋势;②在土壤和地下水修复过程中,VOCs和恶臭的挥发受气象要素和作业的影响,其浓度在总体下降的过程中伴随着阶段性上升现象;③结合GIS技术,电子鼻能初步用于评估土壤和地下水修复现场造成的空间污染情况及对周围

  13. Estudio médico-legal del homicidio en la provincia de Sevilla (2004-2007: Especial referencia a los homicidios de mujeres en el contexto de violencia de género Medico-legal study of the homicide in the province of Seville (2004-07: Special reference to the female victims inside the gender violence

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    J. Lucena

    2008-01-01

    Full Text Available Este estudio retrospectivo analiza los 57 homicidios ocurridos en la provincia de Sevilla durante un periodo de cuatro años (2004-2007. Se han estudiado diversas variables relacionadas con los mismos obteniéndose los siguientes resultados: la tasa media de homicidios ha sido de 0.77 por 100.000 habitantes; el arma blanca es el método más utilizado seguido por el arma de fuego, contusiones y asfixia mecánica; las víctimas son en su mayoría varones (relación hombre/mujer 2:1 con una edad media de 46 ± 21.2 años; el mayor número de casos se registra en fines de semana (sábado y domingo y durante el mes de octubre. El análisis toxicológico de las víctimas detectó etanol en el 47.4%, benzodiacepinas en el 14%, cocaína en el 12.3%, opiáceos en el 10.5% y tetrahidrocannabinol en el 8.8%. Se ha hecho una valoración más detallada de los casos de homicidio dentro del contexto de violencia de género dada su alta incidencia en nuestro país. En 18 de 19 casos, las mujeres murieron a manos de su pareja, ex-pareja o familiar en primer grado. Los resultados han sido comparados con estudios similares realizados tanto en el ámbito nacional como internacionalThis retrospective study analyzes the 57 homicides occurred in the province of Seville in a period of four years (2004-2007. Some variables related with the homicides have been studied with the following results: the mean homicide rate was 0.77 per 100.000 inhabitants; sharp injury was the most frequent mechanism followed by shot gun, contusions and mechanical asphyxia; victims are in major part of cases males (male/female ratio 2:1 with a mean age of 46 ± 21.2 years; homicides are more frequents in weekend (Saturday and Sunday and during October. Toxicological analysis of the victims showed ethanol in 47.4%, benzodiazepines in 14%, cocaine in 12.3%, opium derivatives in 10.5% and tetrahydrocannabinol in 8.8%. A detailed analyses was also carried out in the cases of homicides occurred

  14. Programas de mantenimiento de metadona con servicios auxiliares: un estudio de coste-efectividad Methadone maintenance programs with supplementary services: a cost-effectiveness study

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    E. Puigdollers

    2003-04-01

    Full Text Available Objetivo: Actualmente, los programas de mantenimiento con metadona (PMM son la mejor alternativa de tratamiento para los adictos a opiáceos. Se pretende valorar el coste-efectividad de tres PMM que ofrecían diferentes servicios auxiliares utilizando como medida de efectividad el incremento de la calidad de vida. Métodos: Estudio de seguimiento a 12 meses de 586 pacientes que iniciaron tratamiento con metadona en los centros de atención y seguimiento municipales de Barcelona. Para medir la evolución de la calidad de vida se utilizó el Perfil de Salud de Nottingham (PSN. Se calcularon los costes unitarios estándar y el coste total por paciente a partir de los registros de actividad. Los datos sociodemográficos, de salud y toxicológicos se obtuvieron a través de una entrevista semiestructurada. El análisis coste-efectividad se realizó mediante dos modelos multivariados con idénticas variables de ajuste. Resultados: Cuanto mayor es la intensidad de programa, más elevado es el coste. Los modelos ajustados detectaron un aumento significativo de la calidad de vida (mejora de un 8% en el PSN y de los costes (17% entre el programa de intensidad baja y el de intensidad media. Conclusiones: El programa de media intensidad demostró la mejor relación coste-efectividad pero, dadas las limitaciones del estudio, es difícil ser taxativo en la generalización de sus resultados.Objective: Methadone maintenance programs (MMP currently offer the best treatment for opioid-addicted patients. The aim of this study was to examine the cost-effectiveness of three MMPs that offered varying levels of supplementary services. Health-related quality of life was used as a measure of effectiveness. Methods: A 12-month follow-up study of 586 patients beginning methadone treatment in Drug Care Centers in Barcelona was performed. The Nottingham Health Profile was used to measure quality of life. Standard unit costs and total cost per patient were calculated from

  15. 血浆β-内啡肽水平和阿片类药物治疗癌痛的临床观察

    Institute of Scientific and Technical Information of China (English)

    方美玉; 龚黎燕; 姜初明; 顾丹琳

    2013-01-01

    Objective To investigate the association of plasmaβ-endorphin(BE)levels with cancer pain relief in patients receiving different opioid analgesic modalities. Methods The prospective interventional study was conducted in 42 opi-oid-naieve patients with cancer pain due to lung, liver and gastric malignancies. After initiate opioid titration, pain relief was pro-vided with the fol owing modalities:oral continuous release morphine, oxycodon or transdermal fentanyl. Blood samples were tak-en before treatment and one week later with stable pain relief obtained by various treatment modalities. Plasma BE levels were measured by competitive radioimmunoassay using 125I β-endorphin. Pain levels were determined using a Numerical Rating Scale. Results Average pain scores decreased from 6.93±1.73 (SD) before treatment to 2.24±0.88 (SD) after treatment (P<0.0001). Satisfactory pain relief was obtained with each of the three treatment modalities and was associated with a significant in-crease in plasma BE levels. The mean plasma BE level for al groups was 17.92±3.43 pg/ml before treatment, and that was in-creased to 27.73±5.10 pg/ml after pain relief by three analgesic modalities (P<0.05). Conclusion Plasma BE levels increased with improved pain control in patients with malignancies, which suggests that plasma BE levels may serve as an objective mea-sure of cancer pain severity.%  目的观察癌痛患者接受阿片类药物镇痛治疗前后体内β-内啡肽(BE)的血浆浓度变化,探讨镇痛治疗疗效与血浆BE浓度的关系.方法选取应用阿片类缓释制剂治疗的癌痛患者42例,在治疗前接受数字分级疼痛评分(NRS),并利用放免法检测治疗前BE血浆浓度.1周后疼痛控制后复查NRS和BE血浆浓度.结果患者治疗前后BE血浆浓度有统计学差异[(17.92±3.43)pg/ml vs(27.73±5.10)pg/ml,P<0.05],治疗前后NRS评分也有统计学差异[(6.93±1.73)分vs(2.24±0.88)分,P<0.05].相关性分析提示治疗前后患者

  16. O que os pediatras conhecem sobre avaliação e tratamento da dor no recém-nascido? What do pediatricians know about pain assessment and treatment in newborn infants?

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    Aurimery G. Chermont

    2003-06-01

    Full Text Available OBJETIVO: analisar os conhecimentos dos pediatras que atuam com pacientes neonatais em relação à avaliação e o tratamento da dor do recém-nascido. MÉTODOS: estudo transversal com 104 pediatras (de um total de 110 que trabalhavam em 1999 a 2001, nas sete unidades de terapia intensiva e nos 14 berçários da cidade de Belém, e responderam a um questionário escrito com perguntas a respeito do seu perfil demográfico e do conhecimento de métodos de avaliação e de tratamento da dor no recém-nascido. RESULTADOS: cem por cento dos médicos referiram acreditar que o recém-nascido sente dor, mas apenas um terço deles conhecia alguma escala para avaliar a dor nessa faixa etária. A maioria dos entrevistados referia perceber a presença de dor no recém-nascido por meio de parâmetros comportamentais. O choro foi o preferido para avaliar a dor do bebê a termo; a mímica facial para o prematuro, e a freqüência cardíaca para o neonato em ventilação mecânica. Menos de 10% dos entrevistados diziam usar analgesia para punções venosas e capilares; 30 a 40% referiam empregar analgesia para punções lombares, dissecações venosas, drenagens de tórax e ventilação mecânica. Menos da metade dos entrevistados referiu aplicar medidas para o alívio da dor no pós-operatório de cirurgia abdominal em neonatos. O opióide foi o medicamento mais citado para a analgesia (60%, seguido pelo midazolam (30%. CONCLUSÃO: os pediatras demonstraram pouco conhecimento a respeito dos métodos de avaliação e tratamento da dor no período neonatal. Há necessidade de reciclagens e de atualização no tema para os profissionais de saúde que atuam com recém-nascidos doentes.OBJECTIVE: to analyze the knowledge of pediatricians who work with neonatal patients regarding the evaluation and treatment of pain in newborn infants. METHODS: cross-sectional study of 104 pediatricians (out of 110 who were working during 1999 to 2001 in seven intensive care units

  17. Różnicowanie infekcyjnego zapalenia krążka międzykręgowego i seronegatywnej spondyloartropatii

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    Maria Maślińska

    2011-06-01

    Full Text Available Objawy infekcyjnego zapalenia krążka międzykręgowego mogąimitować objawy spondyloartropatii seronegatywnych i wymagaćróżnicowania wśród tych jednostek chorobowych (tab. I. Spondyloartropatieseronegatywne to grupa zapalnych chorób przebiegającychz zajęciem stawów kręgosłupa i stawów obwodowych.Wśród zapaleń kości i szpiku infekcyjne zapalenie krążka międzykręgowegostanowi ok. 2–4% wszystkich przypadków. Poniżejprzedstawiono opis przypadku 18-letniego mężczyzny diagnozowanegoz powodu podejrzenia spondyloartropatii. U pacjentawystępowały: ból kręgosłupa o charakterze zapalnym, bóle stawówobwodowych oraz epizody stanów gorączkowych. Po wykluczeniuspondyloartropatii ostatecznie rozpoznano u pacjentainfekcyjne zapalenie krążka międzykręgowego. Dzięki diagnostycemetodą rezonansu magnetycznego możliwe było postawienie diag -nozy (ryc. 1, 2 oraz ocena skuteczności leczenia (ryc. 3, 4. Niew każdym przypadku infekcyjnego zapalenia krążka międzykręgowegomożliwe jest ustalenie czynnika etiologicznego, wówczasw leczeniu należy uwzględnić potencjalne czynniki ryzyka zakażeniaoraz najczęstsze patogeny, będące przyczyną spondylodiscitis,takie jak Staphylococcus aureus (w 50% przypadków i Escherichiacoli (23%. Brak klinicznej poprawy po 2 tygodniach optymalniecelowanej antybiotykoterapii drogą dożylną byłby wskazaniem doleczenia chirurgicznego.Womawianym przypadku rozpoznanie kliniczne potwierdził dobryefekt terapeutyczny prowadzonej antybiotykoterapii, wobec czegonie było wskazań do leczenia operacyjnego. Opisany przypadekwskazuje również na konieczność szybkiej oceny kręgosłupa pierwmetodąrezonansu magnetycznego u pacjentów z bólem zapalnymkręgosłupa i objawami ogólnymi wobec wątpliwości co do ich etiologiii braku wyjaśnienia ich przyczyny klasycznym zdjęciem radiologicznym.Ponieważ bardziej narażeni na infekcyjne zapaleniekrążka międzykręgowego są chorzy z obni

  18. Pacientes que rehúsan el tratamiento antirretroviral en el medio penitenciario Patients who refuse antiretroviral treatment in prison

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    L. Sordo-del Castillo

    2008-06-01

    Full Text Available Introducción: En los estudios existentes sobre pacientes VIH+ la población a estudio ha sido tomada de manera homogénea, sin diferenciar aquella que cumple los requerimientos terapéuticos de la que no lo hace. Quizás por la dificultad en el acceso al grupo de pacientes que rehúsan el tratamiento antirretroviral. El medio penitenciario nos permite acceder a esta población, hasta hoy no estudiada. El objetivo de este estudio es describir el estado clínico y psicosocial de los reclusos seropositivos que rehúsan el TARV, comparándolo con el de aquellos que sí están en TARV o no se les indica tomarlo. Métodos: Estudio transversal con 585 reclusos VIH positivos ingresados en tres prisiones andaluzas entre mayo-julio de 2004. Como variable de agrupación se empleó rehusar el TARV, tomarlo o no hacerlo por no estar indicado. Como independientes se incluyeron sociodemográficas, psicosociales, clínicas y relacionadas con el medio penitenciario. Resultados: El 16,8% de los reclusos rehusaban el TARV, mientras el 56,3% estaban en tratamiento y al 26,8% no le estaba indicado. Entre los reclusos que rehusaban el TARV aparece una mayor prevalencia de coinfección por VHC, mayor consumo intrapenitenciario de opiáceos y tratamiento con metadona, más juicios pendientes y más entradas en prisión. Conclusiones: Estos resultados ponen de relieve la existencia de un grupo poblacional, accesible gracias al medio penitenciario, con características propias que no sigue las indicaciones terapéuticas y que representa un riesgo no sólo para su salud, sino para la de la comunidad.Introduction: Current studies of HIV+ patients in the prison population have been carried out without considering differences that might exist between patients who accept retroviral treatment and those who do not. One possible reason for this may be the difficulty in gaining access to patients who refuse antiretroviral treatment. However, the prison environment makes it

  19. Neuroprotección en la encefalopatia hipóxico isquémica perinatal: Tratamientos con eficacia clínica demostrada y perspectivas futuras Neuroprotection in perinatal hypoxic-ischemic encephalopathy: Effective treatment and future perspectives

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    Agustín Legido

    2007-01-01

    Full Text Available El objetivo de este trabajo es revisar el resultado de estudios clínicos recientes que han demostrado el efecto neuroprotector de algunas terapias en la encefalopatía hipóxico-isquémica (EHI perinatal y presentar las perspectivas futuras de otras investigaciones clínicas y experimentales. Terapias con eficacia clínica demostrada. Alopurinol: Bloquea la producción de radicales libres tras hipoxia-isquemia. En un estudio reciente, los niños con corazón izquierdo hipoplásico tratados con alopurinol, pero no aquéllos con otras cardiopatías, tuvieron un número significativamente menor de complicaciones que los controles, incluyendo muerte, convulsiones, coma o problemas cardíacos. Opiáceos: En otro estudio reciente, un grupo de recién nacidos con EHI tratados con morfina o fentanil tuvieron un grado menor de lesión cerebral en la RMN y un mejor pronóstico neurológico. Hipotermia: Tanto la hipotermia localizada (cerebral como la sistémica (todo el cuerpo tienen un efecto neuroprotector en recién nacidos seleccionados tras sufrir EHI. Perspectivas Futuras. Fármacos antiepilépticos. Estos tienen mecanismos de acción múltiple que pueden bloquear la cascada bioquímica de lesión neuronal en EHI. Otras modalidades terapéuticas. Entre ellas hay que destacar el estudio de la terapia neuroprotectora combinada, los factores de crecimiento, la terapia genética, el transplante de células madre y la vacunación neuroprotectora. En conclusión, un mejor conocimiento de los mecanismos moleculares de la patogenia de la EHI y mejores estudios clínicos con terapias neuroprotectoras abrirá nuevas posibilidades terapéuticas aplicables en la práctica clínica. Todo ello mejorará sin lugar a duda el pronóstico de los recién nacidos con EHI.The aim of this paper is to review the results of recent clinical studies of some therapies that have demonstrated a neuroprotective effect in perinatal hypoxic-ischemic encephalopathy (HIE and to

  20. Influence of ethanol and morphine on pain perception evoked by deep tissue injury A influência do etanol e da morfina sobre a percepção dolorosa provocada por injúria tecidual profunda

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    Gustavo Hauber Gameiro

    2004-09-01

    para beber. Após esse período, foi administrado morfina (10 mg/kg i.p. 30 minutos antes da realização do teste da formalina na ATM. A morfina teve o mesmo efeito analgésico nos 2 grupos, demonstrando que o tratamento com etanol não foi capaz de alterar a potência analgésica da morfina. Os resultados mostraram que o etanol é capaz de alterar as respostas nociceptivas relacionadas à dor proveniente de tecidos profundos, como a ATM, e a ausência de interação entre o etanol e a morfina indica que a analgesia induzida pelo etanol é mediada por mecanismos não-opióides.