WorldWideScience

Sample records for operational life extension

  1. The hip and knee replacement operation: an extensive life event.

    Science.gov (United States)

    Gustafsson, Birgitta Åkesdotter; Ekman, Sirkka-Liisa; Ponzer, Sari; Heikkilä, Kristiina

    2010-12-01

    A total hip replacement and a total knee replacement have shown to effectively reduce pain and disability in patients with osteoarthritis of the hip and knee joint despite associated risks. Even though the intervention primarily concerns older people with additional health problems, the patients stand on their feet the day after the operation and are discharged a few days later. Previous research indicates that reflections about life are related to the operation. The aim of this study was to illuminate the meaning of reflections related to hip and knee replacement surgery. A phenomenological hermeneutical approach with a longitudinal design was chosen in order to study the participants' experiences of the hip and knee replacement intervention across the entire perioperative period. Four themes emerged from the structural analysis; choosing the challenge, past memories connect to the current situation, moving from happiness to ordinary everyday life and moving from despair towards reluctant acceptance of unexpected bad conditions for everyday life. There was inner negotiations about having surgery or not, and existential anxiety that reminded people that life cannot be taken for granted. Our findings indicate the operation was seen as an extensive life event including reflections about life and death and about hope and fear. Previous bad experiences of care seemed to influence the way patients dealt with fear and hope. Fear had to be overcome by inner negotiations about undergoing surgery or not. Relief was expressed about surviving the actual operation, but soon after fears arose about how to manage on the actual road to recovery. Hope for a good life grew either stronger or weaker, depending on the progress following the operation. The outcome eventually generated a transition from happiness to ordinary everyday life, or a transition from despair towards reluctant acceptance of unfulfilled expectations. © 2010 The Authors. Scandinavian Journal of Caring Sciences

  2. The Impact Of The MCU Life Extension Solvent On Sludge Batch 8 Projected Operating Windows

    Energy Technology Data Exchange (ETDEWEB)

    Peeler, D. K.; Edwards, T. B.

    2013-06-26

    As a part of the Actinide Removal Process (ARP)/Modular Caustic Side Solvent Extraction Unit (MCU) Life Extension Project, a next generation solvent (NGS) and a new strip acid will be deployed. The strip acid will be changed from dilute nitric acid to dilute boric acid (0.01 M). Because of these changes, experimental testing or evaluations with the next generation solvent are required to determine the impact of these changes (if any) to Chemical Process Cell (CPC) activities, glass formulation strategies, and melter operations at the Defense Waste Processing Facility (DWPF). The introduction of the dilute (0.01 M) boric acid stream into the DWPF flowsheet has a potential impact on glass formulation and frit development efforts since B203 is a major oxide in frits developed for DWPF. Prior knowledge of this stream can be accounted for during frit development efforts but that was not the case for Sludge Batch 8 (SB8). Frit 803 has already been recommended and procured for SB8 processing; altering the frit to account for the incoming boron from the strip effluent (SE) is not an option for SB8. Therefore, the operational robustness of Frit 803 to the introduction of SE including its compositional tolerances (i.e., up to 0.0125M boric acid) is of interest and was the focus of this study. The primary question to be addressed in the current study was: What is the impact (if any) on the projected operating windows for the Frit 803 - SB8 flowsheet to additions of B203 from the SE in the Sludge Receipt and Adjustment Tank (SRAT)? More specifically, will Frit 803 be robust to the potential compositional changes occurring in the SRAT due to sludge variation, varying additions of ARP and/or the introduction of SE by providing access to waste loadings (WLs) of interest to DWPF? The Measurement Acceptability Region (MAR) results indicate there is very little, if any, impact on the projected operating windows for the Frit 803 - SB8 system regardless of the presence or absence of

  3. The Impact Of The MCU Life Extension Solvent On Sludge Batch 8 Projected Operating Windows

    Energy Technology Data Exchange (ETDEWEB)

    Peeler, D. K.; Edwards, T. B.; Stone, M. E.

    2013-08-14

    As a part of the Actinide Removal Process (ARP)/Modular Caustic Side Solvent Extraction Unit (MCU) Life Extension Project, a next generation solvent (NGS) and a new strip acid will be deployed. The strip acid will be changed from dilute nitric acid to dilute boric acid (0.01 M). Because of these changes, experimental testing or evaluations with the next generation solvent are required to determine the impact of these changes (if any) to Chemical Process Cell (CPC) activities, glass formulation strategies, and melter operations at the Defense Waste Processing Facility (DWPF). The introduction of the dilute (0.01M) boric acid stream into the DWPF flowsheet has a potential impact on glass formulation and frit development efforts since B2O3 is a major oxide in frits developed for DWPF. Prior knowledge of this stream can be accounted for during frit development efforts but that was not the case for Sludge Batch 8 (SB8). Frit 803 has already been recommended and procured for SB8 processing; altering the frit to account for the incoming boron from the strip effluent (SE) is not an option for SB8. Therefore, the operational robustness of Frit 803 to the introduction of SE including its compositional tolerances (i.e., up to 0.0125M boric acid) is of interest and was the focus of this study. The primary question to be addressed in the current study was: What is the impact (if any) on the projected operating windows for the Frit 803 – SB8 flowsheet to additions of B2O3 from the SE in the Sludge Receipt and Adjustment Tank (SRAT)? More specifically, will Frit 803 be robust to the potential compositional changes occurring in the SRAT due to sludge variation, varying additions of ARP and/or the introduction of SE by providing access to waste loadings (WLs) of interest to DWPF? The Measurement Acceptability Region (MAR) results indicate there is very little, if any, impact on the projected operating windows for the Frit 803 – SB8 system regardless of the presence or absence

  4. Boiler-turbine life extension

    Energy Technology Data Exchange (ETDEWEB)

    Natzkov, S. [TOTEMA, Ltd., Sofia (Bulgaria); Nikolov, M. [CERB, Sofia (Bulgaria)

    1995-12-01

    The design life of the main power equipment-boilers and turbines is about 105 working hours. The possibilities for life extension are after normatively regulated control tests. The diagnostics and methodology for Boilers and Turbines Elements Remaining Life Assessment using up to date computer programs, destructive and nondestructive control of metal of key elements of units equipment, metal creep and low cycle fatigue calculations. As well as data for most common damages and some technical decisions for elements life extension are presented.

  5. Status and Perspectives of Nuclear Reactor Pressure Vessel Life Extension up to 60 Years Operation in Belgium

    Energy Technology Data Exchange (ETDEWEB)

    Lucon, E.; Chaouadi, R.; Scibetta, M.; Van Walle, E.

    2009-09-15

    The scope of this report involves a safety evaluation of the reactor pressure vessel (RPV) against neutron embrittlement, in the most severely irradiation region (belt line) and in the event of a pressurized thermal shock. The irreplaceable RPV is considered to be the most critical component for lifetime considerations of the nuclear power plant. However, an application for operation extension will also depend upon a number of additional considerations, including the technical assessment of other plant components, as well as non-technical arguments (e.g. political, environmental, economical, strategical that are outside the scope this report. In the hypothesis of a request for operation extension, it is the responsibility of the utilities to provide the safety authorities with an exhaustive dossier demonstrating that safe extended operation is guaranteed. The role of the safety authorities is to critically evaluate the safety dossier for eventually granting the operation extension.

  6. ALGEBRAIC EXTENSION OF *-A OPERATOR

    Institute of Scientific and Technical Information of China (English)

    左红亮; 左飞

    2014-01-01

    In this paper, we study various properties of algebraic extension of∗-A operator. Specifically, we show that every algebraic extension of∗-A operator has SVEP and is isoloid. And if T is an algebraic extension of∗-A operator, then Weyl’s theorem holds for f (T ), where f is an analytic functions on some neighborhood of σ(T ) and not constant on each of the components of its domain.

  7. Fatigue life extension

    Science.gov (United States)

    Matejczyk, D. E.; Lin, J.

    1985-01-01

    Potential fatigue rejuvenation processes were carried out on fatigue-damaged material both with and without observable surface-connected fatigue cracks. The fatigue life of fatigue-damaged MAR-M246(Hf)(DS), a directionally solidified nickel-base superalloy used in turbine airfoils, was extended by reheat treatment. The fatigue life of fatigue-cracked Inconel 718, a wrought nickel-base superalloy used in a wide variety of advanced rocket engine components, was extended by electron-beam welding to close off the surface-connected crack, followed by hot isostatic pressing and reheat treatment.

  8. Life extension and life cycle management

    Energy Technology Data Exchange (ETDEWEB)

    Hoang, H., E-mail: hoa.hoang@ge.co [GE Hitachi Nuclear Energy, 3901 Castle Hayne Rd., Wilmington, NC 28402 (United States)

    2010-10-15

    To continue the effort of nuclear energy as the clean energy offsetting the increase in greenhouse gas emission that contributes to the increased global warming effect, the nuclear industry is focused on the optimization of their current nuclear generation assets. Plant life extension (Plex) and Plant life management (Plim), together with power up rate, are the key strategies for the optimization effort. Plex begins with the process to obtain the regulatory approval for an additional 20 years of operation, beyond the current 40-year limit. This highly standardized process consists of the following steps: 1) Scoping: identify the systems, structures and components for inclusion in the license renewal scope of work. 2) Screening: narrow down the selection of the in-scope systems, structures and components based on passive and long-lived characteristics. 3) Aging management review: demonstrate that aging effects will continue to be managed during the additional 20 years of operation. 4) Time limiting aging analyses: confirm the acceptability of design bases analyses that assume the 40-year plant life as a key input assumptions. To provide a consistent approach for the preparation of the license renewal application, the following are the key guidance documents: NUREG-1800: Standard review plan; NUREG-1801: Generic aging lessons learned; Nuclear Energy Institute NEI 95-10. The objectives of Plim are to focus on improving plant reliability/availability, and to plan for equipment upgrades for efficiency improvement as well as technological obsolescence. Plim is a technical evaluation combined with a risk assessment to produce a long-range business plant with a time horizon of 10 years or longer. Due to its long view nature, this plan will be reviewed on a yearly basis for any required adjustments. The technical evaluation consists of the following major steps: 1) Select systems, structures and components with performance deficiencies experience. 2) Collect operating data

  9. Life Assessment and Life Extension of an Aircraft Wheel

    Directory of Open Access Journals (Sweden)

    M. Aghaie-Khafri

    2012-01-01

    Full Text Available The effect of heat treatment and shot peening on the fatigue life of an aluminum aircraft wheel was studied. The effect of residual stress and heat treatment on the fatigue of specimens was studied by means of fatigue testing, residual stress measurement, and fractography. Finite element simulation was used for life assessment and evaluation of the effect of surface treatments on the life extension of the aircraft wheel. The results obtained show that the operational life of the aircraft wheel extended by imposed compressive residual stress and aging treatment.

  10. Reactor service life extension program

    Energy Technology Data Exchange (ETDEWEB)

    Caskey, G.R.; Sindelar, R.L.; Ondrejcin, R.S.; Baumann, E.W.

    1990-12-31

    A review of the Savannah River Site production reactor systems was initiated in 1980 and led to implementation of the Reactor Materials Program in 1984 to assess reactor safety and reactor service life. The program evaluated performance of the reactor tanks, primary coolant piping, and thermal shields, components of welded construction that were fabricated from Type 304 stainless steel. The structural integrity analysis of the primary coolant system has shown that the pressure boundary is not susceptible to gross rupture, including a double ended guillotine break or equivalent large area bank. Residual service life is potentially limited by two material degradation modes, irradiation damage and intergranular stress corrosion cracking. Analysis of the structural integrity of the tanks and piping has shown that continued safe operation of the reactors for several additional decades is not limited by the material performance of the primary coolant system. Although irradiation damage has not degraded material behavior to an unacceptable level, past experience has revealed serious difficulties with repair welding on irradiated stainless steel. Stress corrosion can be mitigated by newly identified limits on impurity concentrations in the coolant water and by stress mitigation of weld residual stresses. Work continues in several areas: the effects of helium on mechanical behavior of irradiated stainless steel; improved weld methods for piping and the reactor tanks; and a surveillance program to track irradiation effects on the tank walls.

  11. Reactor service life extension program

    Energy Technology Data Exchange (ETDEWEB)

    Caskey, G.R.; Sindelar, R.L.; Ondrejcin, R.S.; Baumann, E.W.

    1990-01-01

    A review of the Savannah River Site production reactor systems was initiated in 1980 and led to implementation of the Reactor Materials Program in 1984 to assess reactor safety and reactor service life. The program evaluated performance of the reactor tanks, primary coolant piping, and thermal shields, components of welded construction that were fabricated from Type 304 stainless steel. The structural integrity analysis of the primary coolant system has shown that the pressure boundary is not susceptible to gross rupture, including a double ended guillotine break or equivalent large area bank. Residual service life is potentially limited by two material degradation modes, irradiation damage and intergranular stress corrosion cracking. Analysis of the structural integrity of the tanks and piping has shown that continued safe operation of the reactors for several additional decades is not limited by the material performance of the primary coolant system. Although irradiation damage has not degraded material behavior to an unacceptable level, past experience has revealed serious difficulties with repair welding on irradiated stainless steel. Stress corrosion can be mitigated by newly identified limits on impurity concentrations in the coolant water and by stress mitigation of weld residual stresses. Work continues in several areas: the effects of helium on mechanical behavior of irradiated stainless steel; improved weld methods for piping and the reactor tanks; and a surveillance program to track irradiation effects on the tank walls.

  12. Substantial Life Extension and Meanings of Life

    NARCIS (Netherlands)

    Derkx, P.H.J.M.

    2009-01-01

    Substantial extension of the human lifespan has become a subject of lively debate. One reason for this is the completion of the Human Genome Project in 2001 and the experimental avenues for biogerontological research the project enables. Another is recent theoretical progress in biogerontology (Aust

  13. Substantial Life Extension and Meanings of Life

    NARCIS (Netherlands)

    Derkx, P.H.J.M.

    2009-01-01

    Substantial extension of the human lifespan has become a subject of lively debate. One reason for this is the completion of the Human Genome Project in 2001 and the experimental avenues for biogerontological research the project enables. Another is recent theoretical progress in biogerontology

  14. Selfadjoint extensions of multipoint singular differential operators

    Directory of Open Access Journals (Sweden)

    Zameddin I. Ismailov

    2013-10-01

    Full Text Available This article describes all selfadjoint extensions of the minimal operator generated by a linear singular multipoint symmetric differential-operator expression for first order in the direct sum of Hilbert spaces of vector-functions. This description is done in terms of the boundary values, and it uses the Everitt-Zettl and the Calkin-Gorbachuk methods. Also the structure of the spectrum of these extensions is studied.

  15. Robustness of Equations Under Operational Extensions

    CERN Document Server

    Mosses, Peter D; Reniers, Michel A; 10.4204/EPTCS.41.8

    2010-01-01

    Sound behavioral equations on open terms may become unsound after conservative extensions of the underlying operational semantics. Providing criteria under which such equations are preserved is extremely useful; in particular, it can avoid the need to repeat proofs when extending the specified language. This paper investigates preservation of sound equations for several notions of bisimilarity on open terms: closed-instance (ci-)bisimilarity and formal-hypothesis (fh-)bisimilarity, both due to Robert de Simone, and hypothesis-preserving (hp-)bisimilarity, due to Arend Rensink. For both fh-bisimilarity and hp-bisimilarity, we prove that arbitrary sound equations on open terms are preserved by all disjoint extensions which do not add labels. We also define slight variations of fh- and hp-bisimilarity such that all sound equations are preserved by arbitrary disjoint extensions. Finally, we give two sets of syntactic criteria (on equations, resp. operational extensions) and prove each of them to be sufficient for...

  16. Central extensions of Lax operator algebras

    Science.gov (United States)

    Schlichenmaier, M.; Sheinman, O. K.

    2008-08-01

    Lax operator algebras were introduced by Krichever and Sheinman as a further development of Krichever's theory of Lax operators on algebraic curves. These are almost-graded Lie algebras of current type. In this paper local cocycles and associated almost-graded central extensions of Lax operator algebras are classified. It is shown that in the case when the corresponding finite-dimensional Lie algebra is simple the two-cohomology space is one-dimensional. An important role is played by the action of the Lie algebra of meromorphic vector fields on the Lax operator algebra via suitable covariant derivatives.

  17. Central extensions of Lax operator algebras

    OpenAIRE

    Schlichenmaier, Martin; Sheinman, Oleg K.

    2007-01-01

    Lax operator algebras were introduced by Krichever and Sheinman as a further development of I.Krichever's theory of Lax operators on algebraic curves. These are almost-graded Lie algebras of current type. In this article local cocycles and associated almost-graded central extensions are classified. It is shown that in the case that the corresponding finite-dimensional Lie algebra is simple the two-cohomology space is one-dimensional. An important role is played by the action of the Lie algebr...

  18. Mixed views about radical life extension

    Directory of Open Access Journals (Sweden)

    Allen Alvarez

    2015-05-01

    Full Text Available Background: Recent studies on public attitudes toward life extension technologies show a mix of ambivalence toward and support for extending the human lifespan (Partridge 2009; Dragojlovic 2013; Funk et al. 2013. Attitudes toward genetic modification of organisms and technological enhancements may be used to categorize individuals according to political or ideological orientation such as technoprogressive or conservative (Hughes 2010 and it could be easy to assume that these categories are related to more general categorizations related to culture, e.g. between Traditional and Secular-rational values in the World Values Survey (Ingelhart & Welzel 2010. This paper discusses how attitudes toward aspects of radical life extension may be related to cultural values as revealed in an online deliberative survey among university students conducted between January 2012 to January 2013. Survey results suggest that attitudes toward radical life extension tend to be mixed among groups categorized as Traditional, Secular-rational, Survivalist, and Self-expressionist. The study explored the relation between responses of 326 university students to 5 key questions on radical life extension (RLE and the cultural values they tend to favor as indicated by their response to 20 statements from the World Values Survey. Design and Method: The survey consisted of 3 stages: an online pre-discussion survey, face-to-face discussion, and post-discussion survey. After completing the 5 main survey questions in stage 1, participants were presented two additional questionnaires: one on cultural attitudes using 20 statements from the 2004-2008 World Values Survey (WVS and another on health attitudes with 12 statements from Dutta-Bergman’s 2004 study. In stage 2, participants were engaged in a face-to-face discussion in class focusing on their responses to the five key questions. After the discussion, they were invited to reconsider the choices and reasons they posted in stage

  19. Life extension of semi-submersible drilling unit

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, I.; Sinclair, C.I.K. [TWI, Cambridge (United Kingdom). Structural Integrity Dept.; Magne, E. [Schlumberger Sedco Forex, Montrouge (France)

    1995-12-31

    This paper describes the life extension of a semi-submersible drilling rig built in the early 1970`s. A nominal design life of 20 years was estimated at the time of building; however, in the interim period, numerous improvements have been made in fatigue life estimation ad life improvement techniques, raising the possibility that a further 20 years of operation could be considered. The life extension strategy made use of a number of aspects of offshore technology which were not available at the time of construction of the rig. Finite element studies and results from offshore research programs were used to gauge the effect of fatigue life improvement techniques. The program demonstrated the feasibility of extending the operation of the rig for a further 20 years, with the interval between in-service inspection increased to every five years. It also provided a valuable database of fracture toughness data for the rig materials, which may be used in future work to address reliability issues.

  20. Computers make rig life extension an option

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The worldwide semisubmersible drilling rig fleet is approaching retirement. But replacement is not an attractive option even though dayrates are reaching record highs. In 1991, Schlumberger Sedco Forex managers decided that an alternative might exist if regulators and insurers could be convinced to extend rig life expectancy through restoration. Sedco Forex chose their No. 704 semisubmersible, an 18-year North Sea veteran, to test their process. The first step was to determine what required restoration, meaning fatigue life analysis of each weld on the huge vessel. If inspected, the task would be unacceptably time-consuming and of questionable accuracy. Instead a suite of computer programs modeled the stress seen by each weld, statistically estimated the sea states seen by the rig throughout its North Sea service and calibrated a beam-element model on which to run their computer simulations. The elastic stiffness of the structure and detailed stress analysis of each weld was performed with ANSYS, a commercially available finite-element analysis program. The use of computer codes to evaluate service life extension is described.

  1. A business model framework for product life extension

    NARCIS (Netherlands)

    Den Hollander, M.C.; Bakker, C.A.

    2012-01-01

    Product life extension is an increase in the utilization period of products. Design research on product life extension strategies has so far mainly focused on technical aspects of products, like ‘prevention engineering’ or ‘design for repair, maintenance and upgradability’, and on individual consume

  2. Life Extension Factor Klotho Enhances Cognition

    Directory of Open Access Journals (Sweden)

    Dena B. Dubal

    2014-05-01

    Full Text Available Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers. Because this allele increased klotho levels in serum, we analyzed transgenic mice with systemic overexpression of klotho. They performed better than controls in multiple tests of learning and memory. Elevating klotho in mice also enhanced long-term potentiation, a form of synaptic plasticity, and enriched synaptic GluN2B, an N-methyl-D-aspartate receptor (NMDAR subunit with key functions in learning and memory. Blockade of GluN2B abolished klotho-mediated effects. Surprisingly, klotho effects were evident also in young mice and did not correlate with age in humans, suggesting independence from the aging process. Augmenting klotho or its effects may enhance cognition and counteract cognitive deficits at different life stages.

  3. Life extension of nuclear power plants. World situation and the USA case

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Pablo T.; Cuesta, Loreto; Serra, Eduardo; Yaguee, Luis [Endesa. C/ Ribera del Loira, No.60, 28042 Madrid (Spain)

    2010-07-01

    Life extension of Nuclear Power Plants above 40 years of operation is an important issue in many countries. The Kyoto limits for CO{sub 2} emissions, the security of supply, the costs and predictability of renewable energy, etc., are putting nuclear energy in the agenda of many countries all around the world. The delay, due to the economic crisis, of the new nuclear projects in many countries, push governments to continue operation of nuclear plants above the 40 years design life. This is the case in the USA, where 59 units have obtained the extension of operation license from 40 to 60 years, and currently have 19 units are in the reviewing process. The life extension of these plants permits savings in CO{sub 2} emissions and in the consumption of additional amounts of fossil fuels. In this paper, the position of the different nuclear countries about the Extension of Life will be reviewed, with a special emphasis on the situation in the USA. In this last case, the NRC approach for operation licenses above 40 years will be explained, and actions taken by nuclear companies in the country will be reviewed. In this country, the debate about life extension over 40 years has been surpassed, and the new technical discussion focuses on the operation of nuclear power plants above 60 years. (authors)

  4. Operation of ULCS - real life

    Directory of Open Access Journals (Sweden)

    Jasna Prpić-Oršić

    2014-12-01

    Full Text Available In this paper the real life operation of ULCS (Ultra Large Container Ships is presented from the point of view of shipmasters. The paper provides interpretation of results of questionnaire filled by masters of large container ships during Tools for Ultra Large Container Ships (TULC EUI FP7 project. This is done in a way that results of questionnaire are further reviewed and commented by experienced master of ULCS. Following phenomena are subject of questionnaire and further discussed in the paper: parametric rolling, slamming, whipping, springing, green water and rogue waves. Special attention is given to the definition of rough sea states as well as to measures that ship masters take to avoid them as well as to the manoeuvring in heavy seas. The role of the wave forecast and weather routing software is also discussed.

  5. Life extension of boilers using weld overlay protection

    Energy Technology Data Exchange (ETDEWEB)

    Lai, G.; Hulsizer, P. [Welding Services Inc., Norcross, GA (United States); Brooks, R. [Welding Services Inc., Welding Services Europe, Spijkenisse (Netherlands)

    1998-12-31

    The presentation describes the status of modern weld overlay technology for refurbishment, upgrading and life extension of boilers. The approaches to life extension of boilers include field overlay application, shop-fabricated panels for replacement of the worn, corroded waterwall and shop-fabricated overlay tubing for replacement of individual tubes in superheaters, generating banks and other areas. The characteristics of weld overlay products are briefly described. Also discussed are successful applications of various corrosion-resistant overlays for life extension of boiler tubes in waste-to-energy boilers, coal-fired boilers and chemical recovery boilers. Types of corrosion and selection of weld overlay alloys in these systems are also discussed. (orig.) 14 refs.

  6. Classification of central extensions of Lax operator algebras

    Science.gov (United States)

    Schlichenmaier, Martin

    2008-11-01

    Lax operator algebras were introduced by Krichever and Sheinman as further developments of Krichever's theory of Lax operators on algebraic curves. They are infinite dimensional Lie algebras of current type with meromorphic objects on compact Riemann surfaces (resp. algebraic curves) as elements. Here we report on joint work with Oleg Sheinman on the classification of their almost-graded central extensions. It turns out that in case that the finite-dimensional Lie algebra on which the Lax operator algebra is based on is simple there is a unique almost-graded central extension up to equivalence and rescaling of the central element.

  7. Establishment of safety verification method for life extension based on periodic safety review

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Soong Pyung; Yeom, Yu Son; Yoon, In Sik; Lee, Jeo Young [Chosun Univ., Gwangju (Korea, Republic of)

    2004-02-15

    Safe management of operating lifetimes of Nuclear Power Plants is a subject of prime interests. As the design life of the Nuclear Power Plant will be ended in 2008, an appropriate procedure for the design life re-assessment or lifetime extension is necessary in Korea. Therefore, the objective of this work is to develop procedural requirements which can be applied to the regulation of lifetime management or life extension of Nuclear Power Plants in Korea. Review on the linkage of the PSR with the extension of the operating lifetime of Nuclear Power Plants was performed to enhance the utilization of PSR results and analysis of the insufficiencies in the license rule in Korea.

  8. On Exceptional Extensions Close to the Generalized Friedrichs Extension of Symmetric Operators

    NARCIS (Netherlands)

    Hassi, Seppo; de Snoo, Henk; Winkler, Henrik

    2007-01-01

    If the Q-function Q corresponding to a closed symmetric operator S with defect numbers (1, 1) and one of its selfadjoint extensions belongs to the Kac class N1 then it is known that all except one of the Q-functions of S belong to N1, too. In this note the situation that the given Q-function does

  9. Structural integrity and life extension of high-temperature components

    Institute of Scientific and Technical Information of China (English)

    WANG Chun; SHEN Shi-ming

    2005-01-01

    Four different topics for high-temperature components, namely the development of the assessment codes for the structural integrity of high-temperature components, the application of continuous damage mechanics and probabilistic damage mode on the life assessment of high-temperature components, the life extension for high-tem perature components and a proposed strategy for remanufacturing of high-temperature components were discussed in this paper. These topics should provide some important insights for the design and re-design of high- temperature components.

  10. Comprehensive life extension evaluated for three-unit station

    Energy Technology Data Exchange (ETDEWEB)

    Morris, C.; Field, J.R.; Wittig, S.

    1988-01-01

    This is an account of a project carried out at the Independence City Power and Light's Blue Valley Station, Missouri, USA. The purpose of this project was to assess the condition of each of the three generating units, to investigate the feasibility and cost of a life extension and turbine capacity improvement program, and to make recommendation for life extension measures. The effort was prompted by deteriorating performance and availability of the units. Also considered were plant modifications to meet anticipated stricter environmental regulations such as acid rain legislation. This project has demonstrated the benefits of a comprehensive program that evaluates the entire plant condition rather than simply reacting to problems as they occur. 2 figs., 5 tabs.

  11. Almost-graded central extensions of Lax operator algebra

    CERN Document Server

    Schlichenmaier, Martin

    2011-01-01

    Lax operator algebras constitute a new class of infinite dimensional Lie algebras of geometric origin. More precisely, they are algebras of matrices whose entries are meromorphic functions on a compact Riemann surface. They generalize classical current algebras and current algebras of Krichever-Novikov type. Lax operators for $\\gl(n)$, with the spectral parameter on a Riemann surface, were introduced by Krichever. In joint works of Krichever and Sheinman their algebraic structure was revealed and extended to more general groups. These algebras are almost-graded. In this article their definition is recalled and classification and uniqueness results for almost-graded central extensions for this new class of algebras are presented. The explicit forms of the defining cocycles are given. If the finite-dimensional Lie algebra on which the Lax operator algebra is based is simple then, up to equivalence and rescaling of the central element, there is a unique non-trivial almost-graded central extension. These results ...

  12. Orion: a glimpse of hope in life span extension?

    Science.gov (United States)

    Muradian, K; Bondar, V; Bezrukov, V; Zhukovsky, O; Polyakov, V; Utko, N

    2010-01-01

    Orion is a multicomponent drug based on derivatives of taurocholic acid and several other compounds. Application of Orion into the feeding medium of Drosophila melanogaster resulted in increased life span and survival at stressful conditions. Two paradoxical features of the drug should be stressed: The "age-threshold" (life span extension was observed only when the drug was applied starting from the second half of life) and induction of "centenarian" flies (older 100 days). Orion enhanced survival at heat shock (38 degrees C) and acidic (pH = 1.6) or alkaline (pH = 11.8) feeding mediums, but not at oxidative stresses modeled by 100% oxygen or application of hydrogen peroxide (H(2)O(2)).

  13. Operational life prediction on gating image intensifier

    Science.gov (United States)

    Dong, Yu-hui; Shen, Zhi-guo; Li, Zhong-li

    2009-07-01

    Operational life is one of the important parameters to evaluate second and super second generation image intensifiers. It can be used not only to monitor manufacturing technique in product line, then the technology on photocathode processing, MCP degassing and MCP producing can be adjusted promptly, but also to eliminate the image intensifiers which have hidden risk on operational life as early as possible. Recently gating image intensifiers are used widely, method to estimate the operational life of gating image intensifier related to its practical operate mode and working condition need to be established urgently. The least square method to analyze the operational life test data in product line was introduced in this paper. Now the data can be analyzed with convenient statistic analyze function on Excel. Using "worksheet function" and "chart wizard" and "data analysis" on Excel to do the least square method calculation, spreadsheets are established to do complex data calculation with worksheet functions. Based on them, formulas to monitor the technology parameters were derived, and the conclusion that the operational life was only related to the decrease slope of photocathode exponential fit curve was made. The decrease slope of photocathode sensitivity exponential fit curve and the decrease percent of the exponential fit photocathode sensitivity can be used to evaluate the qualification of the operational life rapidly. The mathematic models for operational life prediction on image intensifier and gating image intensifier are established respectively based on the acceptable values of the decrease percent of the exponential fit photocathode sensitivity and the expecting signal to noise ratio. The equations predicting the operational life related to duty cycle and input light level on gating image intensifier were derived, and the relationship between them were discussed too. The theory foundation were made herein, so the user can select proper gating image

  14. EXTENSION OF TENSOR PRODUCT FOR OPERATORS ON THE DIRAC OPERATOR EXAMPLE

    Directory of Open Access Journals (Sweden)

    A. A. Boitsev

    2014-07-01

    Full Text Available The paper deals with extension method for the operator which is a sum of tensor products. Boundary triplets approach is used. One of the operators is considered to be densely defined and symmetric with equal deficiency indices, the other one is considered to be bounded and self- adjoint. For self-adjoint extensions construction of the mentioned operator, its boundary triplet is constructed in terms of boundary triplet of symmetric operator. Gamma-field and the Weyl function are obtained using the boundary triplet of symmetric operator. Formulas, connecting gamma-field and the Weyl function of symmetric operator with gamma-field and the Weyl function of the studied operator make it possible to use generic resolvent Krein-type formula for all self-adjoint extensions in this case as well. Theoretical results are applied to the Dirac operator, interesting from the physical point of view. Boundary triplet, gamma-field and the Weyl function are constructed for the Dirac operator. The self-adjoint extensions are obtained by Krein formula. Received results can be useful for correct description of quantum systems interaction.

  15. Metric Extension Operators, Vertex Sparsifiers and Lipschitz Extendability

    CERN Document Server

    Makarychev, Konstantin

    2010-01-01

    We study vertex cut and flow sparsifiers that were recently introduced by Moitra, and Leighton and Moitra. We improve and generalize their results. We give a new polynomial-time algorithm for constructing O(log k / log log k) cut and flow sparsifiers, matching the best existential upper bound on the quality of a sparsifier, and improving the previous algorithmic upper bound of O(log^2 k / log log k). We show that flow sparsifiers can be obtained from linear operators approximating minimum metric extensions. We introduce the notion of (linear) metric extension operators, prove that they exist, and give an exact polynomial-time algorithm for finding optimal operators. We then establish a direct connection between flow and cut sparsifiers and Lipschitz extendability of maps in Banach spaces, a notion studied in functional analysis since 1950s. Using this connection, we prove a lower bound of \\Omega(\\sqrt{log k/log log k}) for flow sparsifiers and a lower bound of \\Omega(\\sqrt[4]{log k/log log k}) for cut sparsif...

  16. The Tortoise Transformation as a Prospect for Life Extension.

    Science.gov (United States)

    Murphy, Timothy F

    2015-12-01

    The value of extending the human lifespan remains a key philosophical debate in bioethics. In building a case against the extension of the species-typical human life, Nicolas Agar considers the prospect of transforming human beings near the end of their lives into Galapagos tortoises, which would then live on decades longer. A central question at stake in this transformation is the persistence of human consciousness as a condition of the value of the transformation. Agar entertains the idea that consciousness could persist in some measure, but he thinks little is to be gained from the transformation because the experiences available to tortoises pale in comparison to those available to human beings. Moreover, he thinks persisting human consciousness and values would degrade over time, being remade by tortoise needs and environment. The value available in the transformation would not, then, make the additional years of life desirable. Agar's account does not, however, dispose of the tortoise transformation as a defensible preference. Some people might still want this kind of transformation for symbolic reasons, but it would probably be better that no human consciousness persist, since that consciousness would be inexpressible as such. Even so, it is not irrational to prefer various kinds of lifespan extension even if they involve significant modifications to human consciousness and values.

  17. Extension theory for elliptic partial differential operators with pseudodifferential methods

    DEFF Research Database (Denmark)

    Grubb, Gerd

    2012-01-01

    This is a short survey on the connection between general extension theories and the study of realizations of elliptic operators A on smooth domains in R^n, n >1. The theory of pseudodifferential boundary problems has turned out to be very useful here, not only as a formulational framework, but also...... for the solution of specific questions. We recall some elements of that theory, and show its application in several cases (including new results), namely to the lower boundedness question, and the question of spectral asymptotics for differences between resolvents....

  18. Nonlinear Control of a Reusable Rocket Engine for Life Extension

    Science.gov (United States)

    Lorenzo, Carl F.; Holmes, Michael S.; Ray, Asok

    1998-01-01

    This paper presents the conceptual development of a life-extending control system where the objective is to achieve high performance and structural durability of the plant. A life-extending controller is designed for a reusable rocket engine via damage mitigation in both the fuel (H2) and oxidizer (O2) turbines while achieving high performance for transient responses of the combustion chamber pressure and the O2/H2 mixture ratio. The design procedure makes use of a combination of linear and nonlinear controller synthesis techniques and also allows adaptation of the life-extending controller module to augment a conventional performance controller of the rocket engine. The nonlinear aspect of the design is achieved using non-linear parameter optimization of a prescribed control structure. Fatigue damage in fuel and oxidizer turbine blades is primarily caused by stress cycling during start-up, shutdown, and transient operations of a rocket engine. Fatigue damage in the turbine blades is one of the most serious causes for engine failure.

  19. LANL Contributions to the B61 LIfe Extension Program

    Energy Technology Data Exchange (ETDEWEB)

    Corpion, Juan Carlos [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-10

    The Los Alamos National Laboratory (LANL) has a long, proud heritage in science and innovation that extends 70 years. Although the Laboratory’s primary responsibility is assuring the safety and reliability of the nation’s nuclear deterrent, Laboratory staff work on a broad range of advanced technologies to provide the best, most effective scientific and engineering solutions to the nation’s critical security challenges. The world is rapidly changing, but this essential responsibility remains the LANL’s core mission. LANL is the Design Laboratory for the nuclear explosive package of the B61 Air Force bomb. The B61-12 Life Extension Program (LEP) activities at LANL will increase the lifetime of the bomb and provide safety and security options to meet security environments both today and in the future. The B61’s multiple-platform functionality, unique safety features, and large number of components make the B61-12 LEP one of the most complex LEPs ever attempted. Over 230 LANL scientists, engineers, technicians, and support personnel from across the Laboratory are bringing decades of interdisciplinary knowledge, technical expertise, and leading-edge capabilities to LANL’s work on the LEP.

  20. Probabilistic fracture mechanics analysis for the life extension estimate of the high flux isotope reactor vessel

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S.J.

    1997-05-01

    The state of the vessel steel embrittlement as a result of neutron irradiation can be measured by its increase in the nil ductility temperature (NDT). This temperature is sometimes referred to as the brittle-ductile transition temperature (DBT) for fracture. The life extension of the High Flux Isotope Reactor (HFIR) vessel is calculated by using the method of fracture mechanics. A new method of fracture probability calculation is presented in this paper. The fracture probability as a result of the hydrostatic pressure test (hydrotest) is used to determine the life of the vessel. The hydrotest is performed in order to determine a safe vessel static pressure. It is then followed by using fracture mechanics to project the safe reactor operation time from the time of the satisfactory hydrostatic test. The life extension calculation provides the following information on the remaining life of the reactor as a function of the NDT increase: (1) the life of the vessel is determined by the probability of vessel fracture as a result of hydrotest at several hydrotest pressures and vessel embrittlement conditions, (2) the hydrotest time interval vs the NDT increase rate, and (3) the hydrotest pressure vs the NDT increase rate. It is understood that the use of a complete range of uncertainties of the NDT increase is equivalent to the entire range of radiation damage that can be experienced by the vessel steel. From the numerical values for the probabilities of the vessel fracture as a result of hydrotest, it is estimated that the reactor vessel life can be extended up to 50 EFPY (100 MW) with the minimum vessel operating temperature equal to 85{degrees}F.

  1. SMART-OLEV—An orbital life extension vehicle for servicing commercial spacecrafts in GEO

    Science.gov (United States)

    Kaiser, Clemens; Sjöberg, Fredrik; Delcura, Juan Manuel; Eilertsen, Baard

    2008-07-01

    Orbital Satellite Services Limited (OSSL) is a satellite servicing company that is developing an orbit life extension vehicle (OLEV) to extend the operational lifetime of geostationary satellites. The industrial consortium of SSC (Sweden), Kayser-Threde (Germany) and Sener (Spain) is in charge to develop and industrialize the space and ground segment. It is a fully commercial program with support of several space agencies during the development phase. The business plan is based on life extension for high value commercial satellites while also providing the satellite operators with various fleet management services such as graveyard burns, slot transfers and on orbit protection against replacement satellite or launch failures. The OLEV spacecraft will be able to dock with a geostationary satellite and uses an electrical propulsion system to extend its life by taking over the attitude control and station keeping functions. The OLEV system is building on the SMART-1 platform developed by Swedish Space Corporation. It was developed for ESA as a technology test-bed to demonstrate the use of electrical propulsion for interplanetary orbit transfer manoeuvres. The concept is called SMART-OLEV and takes advantage of the low cost, low mass SMART-1 platform by a maximum use of recurrent platform technology.

  2. Development of procedural requirements for life extension of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Hun; Son, Moon Kyu [Korea Association for Nuclear Technology, Taejon (Korea, Republic of); Ham, Cheol Hun [The Catholic University of Korea, Seoul (Korea, Republic of); Chang, Keun Sun [Sunmoon Univ., Asan (Korea, Republic of); Paek, Won Phil [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Cheong, Ji Hwan [Baekseok College Cultural Studies, Cheonan (Korea, Republic of)

    2001-03-15

    Current status of regulatory aspects of life extension and upgrading of NPPs is reviewed for major foreign countries. Most countries require similar technical requirements; however, procedural aspects differ country by country. Regulatory systems suitable for NPP life extension is investigated. The procedure and requirements for reassessment of design life should be established first; then it can be incorporated into the PSR system. The concept of 'Current Licensing Basis (CLB)' can be adopted in Korea, but further elaboration for terms and definitions is needed for common understanding between interested groups. The procedure for maintenance and backfitting should also be improved. The Systems, Structures, and Components (SSCs) that require development of regulatory requirements for life extension are identified based on extensive analysis of foreign experiences. By analyzing the rules and regulations related to life extension. Basic directions are suggested to harmonize or establish regulatory systems for life extension, two-step licensing, PSR, and backfitting.

  3. METHODS AND RESEARCH CONCERNING SERVICE LIFE EXTENSION OF SUPORTING STRUCTURES OF TRACTION ROLLING STOCK FOR INDUSTRIAL TRANSPORT

    Directory of Open Access Journals (Sweden)

    O. M. Bondarev

    2014-04-01

    Full Text Available Purpose. The purpose of work is scientifically grounded introduction of the acquired techniques into works for service life extension of the traction and motor rolling stock for industrial transport. Methodology. To achieve the purpose it was analyzed the acquired techniques for service life extension of the traction and motor rolling stock for mainline transport. The acquired techniques during solution of problems concerning the service life extension of rolling stock units were adapted to the locomotives TGM6A and traction aggregates OPE1. Findings. On the basis of experimental and theoretical complex of studies some results were obtained. They gave the ground to determine the possibility of acquired techniques use when solving the problems on service life extension of rolling stock units concerning locomotives TGM6A and traction aggregates OPE1. Originality. On the basis of conducted experimental and theoretical studies scientific maintenance of the works providing extension of service life of traction and motor units of industrial rolling stock was executed. Practical value. Technical solutions and measures, which have to be carried out during operation within the prolonged appointed service life of traction and motor units of industrial rolling stock enterprises using locomotives and traction aggregates to provide the basic technological cycles were developed.

  4. Life Sciences Implications of Lunar Surface Operations

    Science.gov (United States)

    Chappell, Steven P.; Norcross, Jason R.; Abercromby, Andrew F.; Gernhardt, Michael L.

    2010-01-01

    The purpose of this report is to document preliminary, predicted, life sciences implications of expected operational concepts for lunar surface extravehicular activity (EVA). Algorithms developed through simulation and testing in lunar analog environments were used to predict crew metabolic rates and ground reaction forces experienced during lunar EVA. Subsequently, the total metabolic energy consumption, the daily bone load stimulus, total oxygen needed, and other variables were calculated and provided to Human Research Program and Exploration Systems Mission Directorate stakeholders. To provide context to the modeling, the report includes an overview of some scenarios that have been considered. Concise descriptions of the analog testing and development of the algorithms are also provided. This document may be updated to remain current with evolving lunar or other planetary surface operations, assumptions and concepts, and to provide additional data and analyses collected during the ongoing analog research program.

  5. Service Life Extension of the Propulsion System of Long-Term Manned Orbital Stations

    Science.gov (United States)

    Kamath, Ulhas; Kuznetsov, Sergei; Spencer, Victor

    2014-01-01

    . There are no representative ground test articles for some of the components. A 'test everything' approach would require manufacturing new test articles. The paper outlines some of the techniques used for selective testing, by way of cherry picking candidate components based on failure mode effects analysis, system level impacts, hazard analysis, etc. The type of testing required for extending the service life depends on the design and criticality of the component, failure modes and failure mechanisms, life cycle margin provided by the original certification, operational and environmental stresses encountered, etc. When specific failure mechanism being considered and the underlying relationship of that mode to the stresses provided in the test can be correlated by supporting analysis, time and effort required for conducting life extension testing can be significantly reduced. Exposure to corrosive propellants over long periods of time, for instance, lead to specific failure mechanisms in several components used in the propulsion system. Using Arrhenius model, which is tied to chemically dependent failure mechanisms such as corrosion or chemical reactions, it is possible to subject carefully selected test articles to accelerated life test. Arrhenius model reflects the proportional relationship between time to failure of a component and the exponential of the inverse of absolute temperature acting on the component. The acceleration factor is used to perform tests at higher stresses that allow direct correlation between the times to failure at a high test temperature to the temperatures to be expected in actual use. As long as the temperatures are such that new failure mechanisms are not introduced, this becomes a very useful method for testing to failure a relatively small sample of items for a much shorter amount of time. In this article, based on the example of the propulsion system of the first ISS module Zarya, theoretical approaches and practical activities of

  6. Cocoa confers life span extension in Drosophila melanogaster.

    Science.gov (United States)

    Bahadorani, Sepehr; Hilliker, Arthur J

    2008-06-01

    Cocoa is thought to be an excellent source of antioxidants. Here, we investigated the effects of cocoa supplementation on Drosophila melanogaster life span under different oxidative stress conditions. Our results illustrate that a moderate supplementation of cocoa under normoxia increases the average life span, whereas, at higher concentrations, average life span is normal. Under hyperoxia or in a Cu/Zn-superoxide dismutase-deficient background, cocoa exhibited a strong antioxidant activity, significantly increasing the average life span. Nevertheless, cocoa supplementation in a Mn-superoxide dismutase-deficient background enhanced an earlier mortality accompanied by a loss of climbing ability, indicating that cocoa may act as a pro-oxidant in mitochondria under conditions of extreme oxidative stress. Finally, we illustrate that cocoa also acts as a metal chelator in the presence of excess heavy metals, enhancing larval survival to the adult stage on copper or iron-supplemented medium. Taken together, our results document the antioxidative, pro-oxidative, and metal-chelating effects of cocoa on Drosophila melanogaster life span.

  7. Physics based modeling of a series parallel battery pack for asymmetry analysis, predictive control and life extension

    Science.gov (United States)

    Ganesan, Nandhini; Basu, Suman; Hariharan, Krishnan S.; Kolake, Subramanya Mayya; Song, Taewon; Yeo, Taejung; Sohn, Dong Kee; Doo, Seokgwang

    2016-08-01

    Lithium-Ion batteries used for electric vehicle applications are subject to large currents and various operation conditions, making battery pack design and life extension a challenging problem. With increase in complexity, modeling and simulation can lead to insights that ensure optimal performance and life extension. In this manuscript, an electrochemical-thermal (ECT) coupled model for a 6 series × 5 parallel pack is developed for Li ion cells with NCA/C electrodes and validated against experimental data. Contribution of the cathode to overall degradation at various operating conditions is assessed. Pack asymmetry is analyzed from a design and an operational perspective. Design based asymmetry leads to a new approach of obtaining the individual cell responses of the pack from an average ECT output. Operational asymmetry is demonstrated in terms of effects of thermal gradients on cycle life, and an efficient model predictive control technique is developed. Concept of reconfigurable battery pack is studied using detailed simulations that can be used for effective monitoring and extension of battery pack life.

  8. Food losses, shelf life extension and environmental impact of a packaged cheesecake: A life cycle assessment.

    Science.gov (United States)

    Gutierrez, Michele Mario; Meleddu, Marta; Piga, Antonio

    2017-01-01

    Packaging is associated with a high environmental impact. This is also the case in the food industry despite packaging being necessary for maintaining food quality, safety assurance and preventing food waste. The aim of the present study was to identify improvements in food packaging solutions able to minimize environmental externalities while maximizing the economic sustainability. To this end, the life cycle assessment (LCA) methodology was applied to evaluate the environmental performance of new packaging solutions. The environmental impact of packaging and food losses and the balance between the two were examined in relation to a cheesecake that is normally packaged in low density polyethylene film and has a limited shelf life due to microbial growth. A shelf life extension was sought via application of the well-established modified atmosphere packaging (MAP) technique. Samples for MAP (N2/CO2: 70/30) were placed inside multilayer gas barrier trays, which were then wrapped with a multilayer gas and water barrier film (i.e. AerPack packaging); control batches were packaged in gas barrier recycled polyethylene terephthalate (XrPet) trays and wrapped with a XrPet film. Samples were then stored at 20°C and inspected at regular intervals for chemical-physical, microbiological and sensory parameters. Results show that the new packaging solution could considerably extend the shelf life of cheesecakes, thereby reducing food waste and decreasing the overall environmental impact. Moreover, the new packaging allows one to minimize transport costs and to generate economies of scale in manufacturing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Substantial Life Extension and the Fair Distribution of Healthspans.

    Science.gov (United States)

    Wareham, Christopher S

    2016-10-01

    One of the strongest objections to the development and use of substantially life-extending interventions is that they would exacerbate existing unjust disparities of healthy lifespans between rich and poor members of society. In both popular opinion and ethical theory, this consequence is sometimes thought to justify a ban on life-prolonging technologies. However, the practical and ethical drawbacks of banning receive little attention, and the viability of alternative policies is seldom considered. Moreover, where ethicists do propose alternatives, there is scant effort to consider their merits in light of developing world priorities. In response to these shortcomings, I distinguish four policy options and, on the basis of a plausible intuition about fairness, evaluate their implications for a fair distribution of healthy lifespans. I claim that even in developing nations it would be fairest to favor policies that promote equal access to at least one promising category of substantially life-extending intervention: calorie restriction mimetics.

  10. Life-time of turbogenerators and possibilities of its extension. Turbogeneraattoreiden kaeyttoeikae ja sen pidentaemismahdollisuudet

    Energy Technology Data Exchange (ETDEWEB)

    Lindgren, P.; Bovellan, K.; Koistinen, T.; Eerola, H. (Ekono, Helsinki (Finland))

    1987-04-01

    This report has been prepared on an initiative taken by the Industrial Electric and Automation Committee of The Finnish Energy Economy Association. The average running time of turbogenerators of industrial users in Finland is about 100.000 hours and the age about 15-20 years. Under these circumstances the problems of ageing for different components are becoming evident. As and obvious sign of this is the increased number of generator faults and damages in the last few years. The development of structure of different parts and components as well as the development of manufacturing methods and material used during the part 30 years have been described. A special attention has been paid to those matters which are involved in estimated life-time expectance of turbogenerators. Time of introducing new manufacturing methods and material has been defined. Stresses against different components in view of life-time expectance considering the development of structure and material in different manufacturing periods have been explained. Test and inspection methods for defining the state of condition of different components, for locating possible faults and for specifying the preparing measures to be taken, have been explained. Also the requirements for periodic maintenance of different degrees as well as measures to be taken for life-time extension have been described. Factors during different kind of operation of generators and in different operation conditions, which may cause abnormal stresses to certain components have been examined. Also the guidelines for operation as well as criteria for continuation of operation in faulty conditions have been given. A detailed description on generator protection and their testing has been given.

  11. The PREEV project of the Latin American Forum.Regulatory practices on aging and life extension; El proyecto {sup P}reev del Foro Iberoamericano. Practicas reguladoras en envejecimiento y extension de vida.

    Energy Technology Data Exchange (ETDEWEB)

    Figueras, J. M.

    2011-07-01

    The American Forum Plenary approved in 2008 the PREEV project, Regulatory Practices in Aging and Life Extension, whose main objective is to improve the regulatory action with regard to the management programs of life and long-term operation of nuclear power plants in the countries of the region Latin American.

  12. SAVY-4000 Surveillance and Life Extension Program Fiscal Year 2013 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Stone, Timothy A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Blair, Michael W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Weis, Eric [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Veirs, Douglas K. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Smith, Paul Herrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Moore, Murray E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Reeves, Kirk P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kelly, Elizabeth J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Prochnow, David A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worl, Laura A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-03-03

    The Packaging Surveillance Program section of the DOE M441.1-1/sup>1, Nuclear Material Packaging Manual (DOE, 2008) requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” In order to ensure continuing safe storage of nuclear material and the maximization of risk reduction, TA-55 has established a Surveillance Program to ensure storage container integrity for operations within its specified design life. The LANL SAVY-4000 Field Surveillance Plan2 defines the near-term field surveillance plan for SAVY-4000 containers as required by the Manual. A long-term surveillance plan will be established based on the results of the first several years of surveillance and the results of the lifetime extension studies as defined in the Accelerated Aging Plan3. This report details progress in positioning the Surveillance Program for successful implementation in FY14 and status of the Design Life Extension Program in terms of its implementation and data collection for FY13.

  13. A spatio-temporal extension to the map cube operator

    Science.gov (United States)

    Alzate, Juan C.; Moreno, Francisco J.; Echeverri, Jaime

    2012-09-01

    OLAP (On Line Analytical Processing) is a set of techniques and operators to facilitate the data analysis usually stored in a data warehouse. In this paper, we extend the functionality of an OLAP operator known as Map Cube with the definition and incorporation of a function that allows the formulation of spatio-temporal queries. For example, consider a data warehouse about crimes that includes data about the places where the crimes were committed. Suppose we want to find and visualize the trajectory (a trajectory is just the path that an object follows through space as a function of time) of the crimes of a suspect beginning with his oldest crime and ending with his most recent one. In order to meet this requirement, we extend the Map Cube operator.

  14. An extension of the finite cell method using boolean operations

    Science.gov (United States)

    Abedian, Alireza; Düster, Alexander

    2017-01-01

    In the finite cell method, the fictitious domain approach is combined with high-order finite elements. The geometry of the problem is taken into account by integrating the finite cell formulation over the physical domain to obtain the corresponding stiffness matrix and load vector. In this contribution, an extension of the FCM is presented wherein both the physical and fictitious domain of an element are simultaneously evaluated during the integration. In the proposed extension of the finite cell method, the contribution of the stiffness matrix over the fictitious domain is subtracted from the cell, resulting in the desired stiffness matrix which reflects the contribution of the physical domain only. This method results in an exponential rate of convergence for porous domain problems with a smooth solution and accurate integration. In addition, it reduces the computational cost, especially when applying adaptive integration schemes based on the quadtree/octree. Based on 2D and 3D problems of linear elastostatics, numerical examples serve to demonstrate the efficiency and accuracy of the proposed method.

  15. Development of procedural requirements for life extension of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Hoon; Son, Moon Kyu [Korea Association for Nuclear Technology, Taejon (Korea, Republic of); Jeong, Ji Hwan [Baekseok College, Cheonan (Korea, Republic of); Chang, Keun Sun [Sunmoon Univ., Asan (Korea, Republic of); Ham, Chul Hoon [The Catholic University of Korea, Seoul (Korea, Republic of); Chang, Soon Hong [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    2002-03-15

    Technical issues relevant to life extension of NPP were investigated. The GALL report, domestic PSR and periodic inspection rules were reviewed. Technical issues appearing in the safety evaluation reports related to license renewal of Calvert Ciffs 1 and 2 and Qconee 1,2 and 3 NPPs were reviewed. Preliminary study on PSA usage in NPP life extension assessment was performed and further works were suggested. The environment of rules and regulations was analyzed from the viewpoint of plant life extension. Two alternatives are suggested to revise the current domestic nuclear acts.

  16. Organic Finishing Technologies B-52 Paint Life Cycle Extension

    Science.gov (United States)

    2011-08-01

    Material Usage How Project Responds to Goal • Supports C+6 reduction mandated by OSD • Increase Paint Facility availability • Facilitates USAF...2007 MIL-PRF-23377 MIL-PRF-85285 60-001 27 Mar 2006 MIL-PRF-23377 Deft Extended Life Topcoat ( ELT ) 99-GY-001 60-008 24 May 2010 Akzo Nobel 10P20...Akzo 10P20-13 Akzo ECM-6118 (APC) 61-034 UNK UNK UNK 60-055 15 Apr 2010 Deft 02Y-40A Deft ELT 99-GY-13 (APC) 60-018 16 Oct 2008 Akzo 10P20-13 Akzo ECM

  17. 9975 SHIPPING PACKAGE LIFE EXTENSION SURVEILLANCE PROGRAM RESULTS SUMMARY

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, K.; Daugherty, W.; Hackney, B.; Hoffman, E.; Skidmore, E.

    2011-05-27

    Results from the 9975 shipping package Storage and Surveillance Program at the Savannah River Site (SRS) are summarized for justification to extend the life of the 9975 packages currently stored in the K-Area Complex (KAC). This justification is established with the stipulation that surveillance activities will continue throughout the extended time to ensure the continued integrity of the 9975 materials of construction and to further understand the currently identified degradation mechanisms. The 10 year storage life justification was developed prior to storage. A subsequent report was later used to validate the qualification of the 9975 shipping packages for 10 years in storage. However the qualification for the storage period was provided by the monitoring requirements of the 9975 Storage and Surveillance Program. This report summarizes efforts to determine a new safe storage limit for the 9975 shipping package based on the surveillance data collected since 2005 when the 9975 Storage and Surveillance Program began. The Program has demonstrated that the 9975 package has a robust design that can perform under a variety of conditions. The primary emphasis of the on-going 9975 Storage and Surveillance Program is an aging study of the 9975 Viton{reg_sign} containment vessel O-rings and the Celotex{reg_sign} fiberboard thermal insulation at bounding conditions of radiation, elevated temperatures and/or elevated humidity.

  18. PEGylation of antibody fragments for half-life extension.

    Science.gov (United States)

    Jevševar, Simona; Kusterle, Mateja; Kenig, Maja

    2012-01-01

    Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter.

  19. Rehabilitation of heat exchange equipment a key to power plant life extension and performance improvement

    Energy Technology Data Exchange (ETDEWEB)

    Taveau, F.; Huiban, A.M. [Alstom Power Heat Exchange, 78 - Velizy Villacoublay (France)

    2001-07-01

    With the current evolutions of the energy market and the life extension of the power plants, all the equipment initially supplied need one day or another partial or total rehabilitation. For heat exchange equipment, this includes the condensers, feed water heaters and various heat exchangers. Modernization is in particular necessary when in-service monitoring and periodic inspections show significant deteriorations of the tubes and cooling water leakages leading to forced outages or when tube and tube plate materials are no longer suited to cooling water characteristics or to updated specifications of the secondary system. Feedwater heaters and heat exchangers damaged by erosion/corrosion, vibrations, etc. can be re-designed, manufactured and replaced easily. The operation is more complex on condensers and requires technical surveys, study of alternative solutions and has a more direct impact on the global output of the power plant. That is why our conference will focus on the condenser refurbishment. (author)

  20. 75 FR 63506 - Logging Operations; Extension of the Office of Management and Budget's (OMB) Approval of...

    Science.gov (United States)

    2010-10-15

    ... Occupational Safety and Health Administration Logging Operations; Extension of the Office of Management and... specified in its Standard on Logging Operations (29 CFR 1910.266). DATES: Comments must be submitted..., operation, and maintenance of tools, machines, and vehicles the worker/supervisor uses or operates, as...

  1. 9975 SHIPPING PACKAGE LIFE EXTENSION SURVEILLANCE PROGRAM RESULTS SUMMARY

    Energy Technology Data Exchange (ETDEWEB)

    Daugherty, W.; Dunn, K.; Hackney, B.; Hoffman, E.; Skidmore, E.

    2011-01-06

    Results from the 9975 Surveillance Program at the Savannah River Site (SRS) are summarized for justification to extend the life of the 9975 packages currently stored in the K-Area Materials Storage (KAMS) facility from 10 years to 15 years. This justification is established with the stipulation that surveillance activities will continue throughout this extended time to ensure the continued integrity of the 9975 materials of construction and to further understand the currently identified degradation mechanisms. The current 10 year storage life was developed prior to storage. A subsequent report was later used to extend the qualification of the 9975 shipping packages for 2 years for shipping plus 10 years for storage. However the qualification for the storage period was provided by the monitoring requirements of the Storage and Surveillance Program. This report summarizes efforts to determine a new safe storage limit for the 9975 shipping package based on the surveillance data collected since 2005 when the surveillance program began. KAMS is a zero-release facility that depends upon containment by the 9975 to meet design basis storage requirements. Therefore, to confirm the continued integrity of the 9975 packages while stored in KAMS, a 9975 Storage and Surveillance Program was implemented alongside the DOE required Integrated Surveillance Program (ISP) for 3013 plutonium-bearing containers. The 9975 Storage and Surveillance Program performs field surveillance as well as accelerated aging tests to ensure any degradation due to aging, to the extent that could affect packaging performance, is detected in advance of such degradation occurring in the field. The Program has demonstrated that the 9975 package has a robust design that can perform under a variety of conditions. As such the primary emphasis of the on-going 9975 Surveillance Program is an aging study of the 9975 Viton(reg.sign) GLT containment vessel O-rings and the Celotex(reg.sign) fiberboard thermal

  2. A New Extension Theory-based Production Operation Method in Industrial Process

    Institute of Scientific and Technical Information of China (English)

    XU Yuan; ZHU Qunxiong

    2013-01-01

    To explore the problems of dynamic change in production demand and operating contradiction in production process,a new extension theory-based production operation method is proposed.The core is the demand requisition,contradiction resolution and operation classification.For the demand requisition,the deep and comprehensive demand elements are collected by the conjugating analysis.For the contradiction resolution,the conflict between the demand and operating elements are solved by the extension reasoning,extension transformation and consistency judgment.For the operating classification,the operating importance among the operating elements is calculated by the extension clustering so as to guide the production operation and ensure the production safety.Through the actual application in the cascade reaction process of high-density polyethylene (HDPE) of a chemicalplant,cases study and comparison show that the proposed extension theory-based production operation method is significantly better than the traditional experience-based operation method in actual production process,which exploits a new way to the research on the production operating methods for industrial process.

  3. Methods for preservation and extension of shelf life.

    Science.gov (United States)

    Gould, G W

    1996-11-01

    There is potential for spoilage of all foods at some rate or other following harvest, slaughter or manufacture and spoilage may occur at any of the stages between the acquisition of raw materials and the eventual consumption of a food product. These stages include processing, packaging, distribution, retail display, transport, storage and use by the consumer. They are under varying degrees of control that aim to deliver a satisfactory shelf life, to ensure that the finally-consumed product is of high quality and to ensure that it is safe. Spoilage may be caused by a wide range of reactions including some that are essentially physical, some that are chemical, some enzymic and some microbiological. The various forms of microbiological spoilage are preventable to a large degree by a wide range of preservation techniques, most of which act by preventing or inhibiting microbial growth (e.g., chilling, freezing, drying, curing, conserving, vacuum packing, modified atmosphere packing, acidifying, fermenting and adding preservatives). A smaller number of techniques act by inactivating microorganisms (e.g., pasteurization, sterilization and irradiation). Additional techniques restrict the access of microorganisms to products (e.g., aseptic processing and packaging. A major trend is that new and emerging preservation techniques which are coming into use or are under development include more that act by inactivation (e.g., ultrahigh pressure, electroporation, manothermosonication and addition of bacteriolytic enzymes). A further trend is towards the use of procedures that deliver products that are less heavily preserved, have higher quality, are more natural, freer from additives and nutritionally healthier. Less severe preservation procedures are therefore being developed that make use of preservative factors in combinations to deliver (a) less damage to product quality (hurdle technologies); (b) new methods of heating that are better controlled and therefore deliver milder

  4. Submarine Propulsion Shaft Life: Probabilistic Prediction and Extension through Prevention of Water Ingress

    Science.gov (United States)

    2014-06-01

    Inspection. Reliability Engineering and System Safety , 271-292. 47 Shi, P., & Mahadevan, S. (2001). Damage Tolerance Approach for Probabilistic ...Submarine Propulsion Shaft Life: Probabilistic Prediction and Extension through Prevention of Water Ingress By Douglas E. Jonart M.S. Systems...number. 1. REPORT DATE 01 JUN 2014 2. REPORT TYPE 3. DATES COVERED 4. TITLE AND SUBTITLE Submarine Propulsion Shaft Life: Probabilistic

  5. 76 FR 58540 - Proposed Information Collection Request of the ETA 581, Contribution Operations Report; Extension...

    Science.gov (United States)

    2011-09-21

    ... Information Collection Request of the ETA 581, Contribution Operations Report; Extension Without Change AGENCY... Insurance (OUI) of the Employment and Training Administration (ETA) has responsibility for the Tax... Contribution Operations report (Form ETA 581) is a comprehensive report of each state's UI tax operations...

  6. 78 FR 21159 - Additional Requirements for Special Dipping and Coating Operations (Dip Tanks); Extension of the...

    Science.gov (United States)

    2013-04-09

    ... Operations (Dip Tanks); Extension of the Office of Management and Budget's Approval of the Information... Coating Operations (Dip Tanks) (29 CFR 1910.126(g)(4)). DATES: Comments must be submitted (postmarked... Operations (Dip Tanks) (29 CFR 1910.126(g)(4)). The Agency is requesting to retain its previous burden...

  7. Origins of life: An operational definition

    Science.gov (United States)

    Fleischaker, Gail Raney

    1990-03-01

    Two very different models are used for the scientific study of life's origins: in the Troland-Muller model, life is molecular and its defining characteristic is gene function; in the Oparin-Haldane model, life is cellular and its defining characteristic is metabolic function. While each of these models implicitly defines the living, neither provides criteria by which theemergence of life could be recognized in the laboratory. Anoperational definition of the living makes explicit the system logic of metabolic self-production: (1) that whatever form it may take, life is a function of its biochemical processes; (2) that no single biochemical process has integrity apart from an entire network of processes; (3) that a network of processes can have continuity only by being enclosed within a boundary structure, i.e., by the selective partition of a microenvironment as a domain for the bioenergetic-biosynthetic network; and (4) that life is a single phenomenon, distinct in its continuity of capture and storage of energy in such networks, driving the processes that produce its material constituents. This paper presentsautopoiesis as life-defining and discusses the utility of its criteria in our search for the origins of life on Earth. Enactment of the autopoietic criteria would result in aminimal cell and would demonstrate the experimental recapitulation of life's Archaean origins.

  8. Life Span Extension and Neuronal Cell Protection by Drosophila Nicotinamidase*S⃞

    OpenAIRE

    Balan, Vitaly; Gregory S Miller; Kaplun, Ludmila; Balan, Karina; Chong, Zhao-Zhong; Li, Faqi; Kaplun, Alexander; Mark F A VanBerkum; Arking, Robert; Freeman, D. Carl; Maiese, Kenneth; Tzivion, Guri

    2008-01-01

    The life span of model organisms can be modulated by environmental conditions that influence cellular metabolism, oxidation, or DNA integrity. The yeast nicotinamidase gene pnc1 was identified as a key transcriptional target and mediator of calorie restriction and stress-induced life span extension. PNC1 is thought to exert its effect on yeast life span by modulating cellular nicotinamide and NAD levels, resulting in increased activity of Sir2 family class III histone ...

  9. Rehabilitation and extension of the useful operating life of a high pressure casing of the 75 MW steam turbine of the thermoelectric power plant President Juarez in Rosarito, B.C.; Rehabilitacion y extension de vida util de una carcasa de alta presion de la turbina de vapor de 75 MW de la central termoelectrica Presidente Juarez en Rosarito, B.C.

    Energy Technology Data Exchange (ETDEWEB)

    Mazur C, Zdzislaw; Hernandez R, Alejandro; Luna R, Alberto [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Fernandez, Rafael; Nieblas, Enrique [Comision Federal de Electricidad, Rosarito, Baja California (Mexico)

    2004-07-01

    The effective operation of the steam turbines is important to the world industries, but as all machinery, it is necessary to constantly examine and give maintenance to this equipment with the purpose of producing better results. Yet, many steam turbines arrive at an operation period of 30 or 40 years, over their original design capacity. A factor like this, only augments the probabilities of future problems with the casings, such as: thermal fatigue fissures, deformation of the horizontal union and erosion problems in the low pressure housings. The deformation of the casing can affect its capacity to maintain aligned the stationary parts of the turbine, as a consequence, damages can appear in the fixed and rotary components by interference or friction. Also, the water induction can deform the casing to such a degree that, the alignment of the stationary parts is altered until it causes contact and friction between stationary and rotary parts. However, depending on the type and degree of the casing deformation, different methods of rehabilitation can be applied. The core goal is to recover the planarity of the union of the flanges, re-machining the plane of the flange of the upper and lower casing or, alternatively, to carry out a scraping by hand. [Spanish] El funcionamiento eficaz de las turbinas de vapor es importante para las industrias del mundo, pero como toda maquinaria, es necesario examinar y dar mantenimiento constantemente a este equipo con la finalidad de producir mejores resultados. Con todo, muchas turbinas de vapor llegan a un periodo de operacion de 30 o 40 anos, por encima de su capacidad de diseno original. Un factor como este, solo eleva las probabilidades de futuros problemas con las carcasas, tales como: fisuras por fatiga termica, deformacion de la union horizontal y problemas de erosion en las carcasas de baja presion. La deformacion de la carcasa puede afectar su capacidad para mantener alineadas las partes estacionarias de la turbina, como

  10. 77 FR 58996 - Multiple Award Schedule (MAS) Program Continuous Open Season-Operational Change; Extension of...

    Science.gov (United States)

    2012-09-25

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Multiple Award Schedule (MAS) Program Continuous Open Season-- Operational Change; Extension of Comment Period AGENCY: Federal Acquisition Service (FAS), General Services Administration (GSA). ACTION...

  11. 75 FR 15718 - MMS Information Collection Activity: 1010-0086, Sulphur Operations, Extension of a Collection...

    Science.gov (United States)

    2010-03-30

    ... Minerals Management Service MMS Information Collection Activity: 1010-0086, Sulphur Operations, Extension... of extension of an information collection (1010-0086). SUMMARY: To comply with the Paperwork...; Herndon, Virginia 20170-4817. Please reference ICR 1010-0086 in your comment and include your name...

  12. Modeling Operating Modes during Plant Life Cycle

    DEFF Research Database (Denmark)

    Jørgensen, Sten Bay; Lind, Morten

    2012-01-01

    Modelling process plants during normal operation requires a set a basic assumptions to define the desired functionalities which lead to fullfillment of the operational goal(-s) for the plant. However during during start-up and shut down as well as during batch operation an ensemble of interrelate...

  13. Extending the International Space Station Life and Operability

    Science.gov (United States)

    Cecil, Andrew J.; Pitts, R. Lee; Sparks, Ray N.; Wickline, Thomas W.; Zoller, David A.

    2012-01-01

    The International Space Station (ISS) is in an operational configuration with final assembly complete. To fully utilize ISS and extend the operational life, it became necessary to upgrade and extend the onboard systems with the Obsolescence Driven Avionics Redesign (ODAR) project. ODAR enabled a joint project between the Johnson Space Center (JSC) and Marshall Space Flight Center (MSFC) focused on upgrading the onboard payload and Ku-Band systems, expanding the voice and video capabilities, and including more modern protocols allowing unprecedented access for payload investigators to their on-orbit payloads. The MSFC Huntsville Operations Support Center (HOSC) was tasked with developing a high-rate enhanced Functionally Distributed Processor (eFDP) to handle 300Mbps Return Link data, double the legacy rate, and incorporate a Line Outage Recorder (LOR). The eFDP also provides a 25Mbps uplink transmission rate with a Space Link Extension (SLE) interface. HOSC also updated the Payload Data Services System (PDSS) to incorporate the latest Consultative Committee for Space Data Systems (CCSDS) protocols, most notably the use of the Internet Protocol (IP) Encapsulation, in addition to the legacy capabilities. The Central Command Processor was also updated to interact with the new onboard and ground capabilities of Mission Control Center -- Houston (MCC-H) for the uplink functionality. The architecture, implementation, and lessons learned, including integration and incorporation of Commercial Off The Shelf (COTS) hardware and software into the operational mission of the ISS, is described herein. The applicability of this new technology provides new benefits to ISS payload users and ensures better utilization of the ISS by the science community

  14. SET-VALUED EXTENSION OF OPERATORS VIA STEINER SELECTIONS (Ⅰ)-THEORETICAL RESULTS

    Institute of Scientific and Technical Information of China (English)

    Ter(a)n,Pedro; L(o)pez-D(I)an,Miguel

    2002-01-01

    A way to extend operators in spaces of continuous functions to spaces ofcontinuous set-valued functions is proposed. This extension is developed through the Steinerselections of the set-valued functions. Their properties and characteristics of theconvergence of sequences of operators of this class are studied. In Part Ⅱ of this seriessome applications to approximation theory will be shown.

  15. 76 FR 3175 - Proposed Extension of Existing Information Collection; Hoist Operators' Physical Fitness

    Science.gov (United States)

    2011-01-19

    ...' Physical Fitness AGENCY: Mine Safety and Health Administration, Labor. ACTION: Notice of request for public... collection of information in 30 CFR 56.19057 and 57.19057--Hoist Operators' Physical Fitness. MSHA does not... extension of the information collection for 30 CFR 56.19057 and 57.19057 on hoist operators'...

  16. Nuclear power plant life extension: How aging affects performance of containments & other structures

    Institute of Scientific and Technical Information of China (English)

    Robert A Dameron; Sun Junling

    2013-01-01

    This paper focuses on how aging can affect performance of safety-related structures in nuclear power plant (NPP).Knowledge and assessment of impacts of aging on structures are essential to plant life extension analysis,especially performance to severe loadings such as loss-of-coolant-accidents or major seismic events.Plant life extension issues are of keen interest in countries (like the United States) which have a large,aging fleet of NPPs.This paper addresses the overlap and relationship of structure aging to severe loading performance,with particular emphasis on containment structures.

  17. Improving Environmental Management on Small-scale Farms: Perspectives of Extension Educators and Horse Farm Operators

    Science.gov (United States)

    Rebecca, Perry-Hill; Linda, Prokopy

    2015-01-01

    Although the number of small-scale farms is increasing in North America and Europe, few studies have been conducted to better understand environmental management in this sector. We investigate this issue by examining environmental management on horse farms from both the perspective of the "expert" extension educator and horse farm operator. We conducted a Delphi survey and follow-up interviews with extension educators in Indiana and Kentucky. We also conducted interviews and farm assessments with 15 horse farm operators in the two states. Our results suggest a disconnection between the perceptions of extension educators and horse farm operators. Extension educators believed that operators of small horse farms are unfamiliar with conservation practices and their environmental benefits and they found it difficult to target outreach to this audience. In the interviews with horse farm operators, we found that the majority were somewhat familiar with conservation practices like rotational grazing, soil testing, heavy use area protection, and manure composting. It was not common, however, for practices to be implemented to generally recognized standards. The horse farm respondents perceived these practices as interrelated parts of a system of farm management that has developed over time to best deal with the physical features of the property, needs of the horses, and available resources. Because conservation practices must be incorporated into a complex farm management system, traditional models of extension (i.e., diffusion of innovations) may be inappropriate for promoting better environmental management on horse farms.

  18. LEVERAGING AGING MATERIALS DATA TO SUPPORT EXTENSION OF TRANSPORTATION SHIPPING PACKAGES SERVICE LIFE

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, K. [Savannah River National Laboratory; Bellamy, S. [Savannah River National Laboratory; Daugherty, W. [Savannah River National Laboratory; Sindelar, R. [Savannah River National Laboratory; Skidmore, E. [Savannah River National Laboratory

    2013-08-18

    Nuclear material inventories are increasingly being transferred to interim storage locations where they may reside for extended periods of time. Use of a shipping package to store nuclear materials after the transfer has become more common for a variety of reasons. Shipping packages are robust and have a qualified pedigree for performance in normal operation and accident conditions but are only certified over an approved transportation window. The continued use of shipping packages to contain nuclear material during interim storage will result in reduced overall costs and reduced exposure to workers. However, the shipping package materials of construction must maintain integrity as specified by the safety basis of the storage facility throughout the storage period, which is typically well beyond the certified transportation window. In many ways, the certification processes required for interim storage of nuclear materials in shipping packages is similar to life extension programs required for dry cask storage systems for commercial nuclear fuels. The storage of spent nuclear fuel in dry cask storage systems is federally-regulated, and over 1500 individual dry casks have been in successful service up to 20 years in the US. The uncertainty in final disposition will likely require extended storage of this fuel well beyond initial license periods and perhaps multiple re-licenses may be needed. Thus, both the shipping packages and the dry cask storage systems require materials integrity assessments and assurance of continued satisfactory materials performance over times not considered in the original evaluation processes. Test programs for the shipping packages have been established to obtain aging data on materials of construction to demonstrate continued system integrity. The collective data may be coupled with similar data for the dry cask storage systems and used to support extending the service life of shipping packages in both transportation and storage.

  19. Hamiltonian structure of an operator valued extension of Super KdV equations

    CERN Document Server

    Restuccia, A

    2014-01-01

    An extension of the super Korteweg-de Vries integrable system in terms of operator valued functions is obtained. In particular the extension contains the $N=1$ Super KdV and coupled systems with functions valued on a symplectic space. We introduce a Miura transformation for the extended system and obtain its hamiltonian structure. We also obtain an extended Gardner transformation which allows to find an infinite number of conserved quantities of the extended system.

  20. Quality of life of nurses in the operating room

    Directory of Open Access Journals (Sweden)

    Raquel Murano Alfaia dos Santos

    2009-03-01

    Full Text Available Objective: To evaluate the quality of life of operating room nurses and collect their opinions as to the influence their professional activity exerts on their quality of life. Methods: This was a cross-sectional study carried out on a sample of 24 nurses that work in the operating room of a large private hospital in the city of São Paulo. Two questionnaires were applied; one was designed by the authors of this research project, and the other was the Quality of Life Questionnaire (WHOQOL-BREF. Rresults: As to quality of life, the environment domain obtained the highest score, while the psychological domain obtained the lowest. When asked if their professional activity in the operating room influenced their quality of life, most responded affirmatively. Regarding the justifications offered by the nurses for the influence of their professional activity on their quality of life, 50% mentioned environment-related stress, responsibilities, duties, risk situations, relationships with the multiprofessional team, and the type of work carried out in the operating room. Cconclusions: The psychological domain obtained the lowest score in the nurse quality of life evaluation, pointing out the need to facilitate and/or encourage nurses to seek psychological support. As to the influence of their professional activity on their quality of life, the nurses mentioned stress related to their work environment and professional activities in the operating room. This highlights the importance of managers in this area, paying greater attention to the individual and collective needs of their employees.

  1. Quantification of the Service Life Extension and Environmental Benefit of Chloride Exposed Self-Healing Concrete.

    Science.gov (United States)

    Van Belleghem, Bjorn; Van den Heede, Philip; Van Tittelboom, Kim; De Belie, Nele

    2016-12-23

    Formation of cracks impairs the durability of concrete elements. Corrosion inducing substances, such as chlorides, can enter the matrix through these cracks and cause steel reinforcement corrosion and concrete degradation. Self-repair of concrete cracks is an innovative technique which has been studied extensively during the past decade and which may help to increase the sustainability of concrete. However, the experiments conducted until now did not allow for an assessment of the service life extension possible with self-healing concrete in comparison with traditional (cracked) concrete. In this research, a service life prediction of self-healing concrete was done based on input from chloride diffusion tests. Self-healing of cracks with encapsulated polyurethane precursor formed a partial barrier against immediate ingress of chlorides through the cracks. Application of self-healing concrete was able to reduce the chloride concentration in a cracked zone by 75% or more. As a result, service life of steel reinforced self-healing concrete slabs in marine environments could amount to 60-94 years as opposed to only seven years for ordinary (cracked) concrete. Subsequent life cycle assessment calculations indicated important environmental benefits (56%-75%) for the ten CML-IA (Center of Environmental Science of Leiden University-Impact Assessment) baseline impact indicators which are mainly induced by the achievable service life extension.

  2. Quantification of the Service Life Extension and Environmental Benefit of Chloride Exposed Self-Healing Concrete

    Directory of Open Access Journals (Sweden)

    Bjorn Van Belleghem

    2016-12-01

    Full Text Available Formation of cracks impairs the durability of concrete elements. Corrosion inducing substances, such as chlorides, can enter the matrix through these cracks and cause steel reinforcement corrosion and concrete degradation. Self-repair of concrete cracks is an innovative technique which has been studied extensively during the past decade and which may help to increase the sustainability of concrete. However, the experiments conducted until now did not allow for an assessment of the service life extension possible with self-healing concrete in comparison with traditional (cracked concrete. In this research, a service life prediction of self-healing concrete was done based on input from chloride diffusion tests. Self-healing of cracks with encapsulated polyurethane precursor formed a partial barrier against immediate ingress of chlorides through the cracks. Application of self-healing concrete was able to reduce the chloride concentration in a cracked zone by 75% or more. As a result, service life of steel reinforced self-healing concrete slabs in marine environments could amount to 60–94 years as opposed to only seven years for ordinary (cracked concrete. Subsequent life cycle assessment calculations indicated important environmental benefits (56%–75% for the ten CML-IA (Center of Environmental Science of Leiden University–Impact Assessment baseline impact indicators which are mainly induced by the achievable service life extension.

  3. The Ethics of Human Life Extension: The Second Argument from Evolution.

    Science.gov (United States)

    Gyngell, Chris

    2015-12-01

    One argument that is sometimes made against pursuing radical forms of human life extension is that such interventions will make the species less evolvable, which would be morally undesirable. In this article, I discuss the empirical and evaluative claims of this argument. I argue that radical increases in life expectancy could, in principle, reduce the evolutionary potential of human populations through both biological and cultural mechanisms. I further argue that if life extension did reduce the evolvability of the species, this will be undesirable for three reasons: (1) it may increase the species' susceptibility to extinction risks, (2) it may adversely affect institutions and practices that promote well-being, and (3) it may impede moral progress.

  4. The unexpected outcomes of anti-aging, rejuvenation, and life extension studies: an origin of modern therapies.

    Science.gov (United States)

    Stambler, Ilia

    2014-06-01

    The search for life-extending interventions has been often perceived as a purely academic pursuit, or as an unorthodox medical enterprise, with little or no practical outcome. Yet, in fact, these studies, explicitly aiming to prolong human life, often constituted a formidable, though hardly ever acknowledged, motivation for biomedical research and discovery. At least several modern biomedical fields have originated directly from rejuvenation and life extension research: (1) Hormone replacement therapy was born in Charles-Edouard Brown-Séquard's rejuvenation experiments with animal gland extracts (1889). (2) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged "orthobiosis" (c. 1900). (3) The development of clinical endocrinology owed much to Eugen Steinach's "endocrine rejuvenation" operations (c. 1910s-1920s). (4) Tissue transplantations in humans (allografts and xenografts) were first widely performed in Serge Voronoff's "rejuvenation by grafting" experiments (c. 1910s-1920s). (5) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization (c. 1900-1920). (6) Cell therapy (and particularly human embryonic cell therapy) was first widely conducted by Paul Niehans for the purposes of rejuvenation as early as the 1930s. Thus, the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine. Notably, the common principle of these studies was the proactive maintenance of stable, long-term homeostasis of the entire organism.

  5. Self-adjoint Extensions of Schrödinger Operators with ?-magnetic Fields on Riemannian Manifolds

    Directory of Open Access Journals (Sweden)

    T. Mine

    2010-01-01

    Full Text Available We consider the magnetic Schr¨odinger operator on a Riemannian manifold M. We assume the magnetic field is given by the sum of a regular field and the Dirac δ measures supported on a discrete set Γ in M. We give a complete characterization of the self-adjoint extensions of the minimal operator, in terms of the boundary conditions. The result is an extension of the former results by Dabrowski-Šťoviček and Exner-Šťoviček-Vytřas.

  6. Formal Pseudodifferential Operators in One and Several Variables, Central Extensions, and Integrable Systems

    Directory of Open Access Journals (Sweden)

    Jarnishs Beltran

    2015-01-01

    Full Text Available We review some aspects of the theory of Lie algebras of (twisted and untwisted formal pseudodifferential operators in one and several variables in a general algebraic context. We focus mainly on the construction and classification of nontrivial central extensions. As applications, we construct hierarchies of centrally extended Lie algebras of formal differential operators in one and several variables, Manin triples and hierarchies of nonlinear equations in Lax and zero curvature form.

  7. Calibration and Extension of a Discrete Event Operations Simulation Modeling Multiple Un-Manned Aerial Vehicles Controlled by a Single Operator

    Science.gov (United States)

    2013-03-01

    CALIBRATION AND EXTENSION OF A DISCRETE EVENT OPERATIONS SIMULATION MODELING MULTIPLE UN-MANNED AERIAL VEHICLES...DISCRETE EVENT OPERATIONS SIMULATION MODELING MULTIPLE UN-MANNED AERIAL VEHICLES CONTROLLED BY A SINGLE OPERATOR THESIS Presented to the...ENV-13-M-34 CALIBRATION AND EXTENSION OF A DISCRETE EVENT OPERATIONS SIMULATION MODELING MULTIPLE UN-MANNED AERIAL VEHICLES CONTROLLED BY

  8. Shelf life extension of whole-wheat breadsticks: Formulation and packaging strategies.

    Science.gov (United States)

    Alamprese, Cristina; Cappa, Carola; Ratti, Simona; Limbo, Sara; Signorelli, Marco; Fessas, Dimitrios; Lucisano, Mara

    2017-09-01

    The aim of this study was the shelf life extension of whole-wheat breadsticks through the addition of a rosemary extract and packaging under nitrogen. Shelf life was studied at four temperatures (20, 27, 35, 48°C) for up to 200 storage days. The minimal changes observed in moisture, water activity and texture of the samples, coupled with the high peroxide values (13-539meqO2/kgfat) measured at the end of storage, and the exponential increase of hexanal concentrations (up to 13-34mg/kg) confirmed that quality decay of whole-wheat breadsticks is mainly associated to lipid oxidation. The kinetic study of oxidation development and the consumer sensory acceptance determined by the survival analysis demonstrated that the rosemary extract addition yields a 42% shelf life extension, higher than that observed using nitrogen in the package (24-29%). The combination of the formulation and packaging strategies gave the best result (83% shelf life extension at 25°C). Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Shane L Rea

    2007-10-01

    Full Text Available Prior studies have shown that disruption of mitochondrial electron transport chain (ETC function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in humans are known to be pathologically life-shortening. In this study, we have undertaken the first formal investigation of the role of partial mitochondrial ETC inhibition and its contribution to the life-extension phenotype of C. elegans. We have developed a novel RNA interference (RNAi dilution strategy to incrementally reduce the expression level of five genes encoding mitochondrial proteins in C. elegans: atp-3, nuo-2, isp-1, cco-1, and frataxin (frh-1. We observed that each RNAi treatment led to marked alterations in multiple ETC components. Using this dilution technique, we observed a consistent, three-phase lifespan response to increasingly greater inhibition by RNAi: at low levels of inhibition, there was no response, then as inhibition increased, lifespan responded by monotonically lengthening. Finally, at the highest levels of RNAi inhibition, lifespan began to shorten. Indirect measurements of whole-animal oxidative stress showed no correlation with life extension. Instead, larval development, fertility, and adult size all became coordinately affected at the same point at which lifespan began to increase. We show that a specific signal, initiated during the L3/L4 larval stage of development, is sufficient for initiating mitochondrial dysfunction-dependent life extension in C. elegans. This stage of development is characterized by the last somatic cell divisions normally undertaken by C. elegans and also by massive mitochondrial DNA expansion. The coordinate effects of mitochondrial dysfunction on several cell cycle-dependent phenotypes, coupled with recent findings directly linking cell cycle progression with mitochondrial activity in C. elegans, lead us to propose that cell cycle checkpoint control

  10. On extension results for n-cyclically monotone operators in reflexive Banach spaces

    CERN Document Server

    Bot, Radu Ioan

    2009-01-01

    In this paper we provide some extension results for n-cyclically monotone operators in reflexive Banach spaces by making use of the Fenchel duality. In this way we give a positive answer to a question posed by Bauschke and Wang in [4].

  11. Role of mechanics in PLEX [plant life extension]: A technical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Garud, Y.S. (S. Levey, Inc., Campbell, CA (United States))

    1993-01-01

    The mechanics of materials and structures plays an important role in the majority of life prediction and structural integrity evaluations. In many industrial systems this role gets integrated with effects of service environment and material aging; corrosion, oxidation, and irradiation are examples of such effects which require an interdisciplinary approach. Degradation mechanisms related to these effects have been identified as potentially significant to plant life extension (PLEX). In-service inspection and component monitoring are some of the cost effective steps emphasized in the life extension works; usefulness of the results of these steps can be enhanced through the methods needed for the component condition assessment. These methods, therefore, demand an ever increasing accuracy and improvements requiring a better appreciation and integration of the mechanics. The above aspects of PLEX are critically examined with a review of key degradation mechanisms elucidating the role of mechanics. Current design basis and recent developments in the life prediction techniques are discussed identifying areas of further work. Stress corrosion cracking, corrosion fatigue, pressurized thermal shock, and long term material stability under thermal and irradiation aging are some of the phenomena emphasized in this work. The significance of mechanics in treating the subcritical crack growth due to these phenomena is discussed. Also, from the point of view of final failure step, the role of impact energy and fracture toughness is examined with consideration of the time dependant changes in these properties. A perspective is also provided on the assessment of remaining life and safety margins with particular reference to the needs and challenges of the plant life extension. 20 refs., 2 figs.

  12. Extension of the Operating Point of the Mercury IVA from 6 to 8 MV

    Science.gov (United States)

    2013-06-01

    EXTENSION OF THE OPERATING POINT OF THE MERCURY IVA FROM 6 TO 8 MV∗ R. J. Allenξ, R. J. Commisso, G. Coopersteina, P. F. Ottingera and J. W...over 200 shots at 8 MV. I. INTRODUCTION The original design of the Mercury IVA allowed operation at 6 MV and 300 kA [1]. Although the...Operating Point Of The Mercury Iva From 6 To 8 Mv 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e

  13. Moral pluralism versus the total view: why Singer is wrong about radical life extension.

    Science.gov (United States)

    Blackford, R

    2009-12-01

    Peter Singer has argued that we should not proceed with a hypothetical life-extension drug, based on a scenario in which developing the drug would fail to achieve the greatest sum of happiness over time. However, this is the wrong test. If we ask, more simply, which policy would be more benevolent, we reach a different conclusion from Singer's: even given his (admittedly questionable) scenario, development of the drug should go ahead. Singer's rigorous utilitarian position pushes him in the direction of an implausible "total view" utilitarianism when it encounters the problems presented by certain thought experiments. A more pluralistic account of the nature of morality promises to solve these problems, and in this case it reaches a benevolent recommendation on life-extension technology.

  14. Radurization of bananas under commercial conditions: Pt. 2. Shelf- or market-life extension

    Energy Technology Data Exchange (ETDEWEB)

    Brodrick, H.T.; Thord-Gray, R.S.; Strydom, G.J. (Nuclear Development Corp. of South Africa (Pty.) Ltd., Pelindaba, Pretoria)

    1984-04-01

    In two large-scale commercial trials with bananas, a 2 to 4 d extension in marketable life was achieved by radurisation at a dose of 0,60 kGy. The criteria for marketability were based primarily on skin colour and fruit firmness. It was also observed that browning associated with the handling of ripe fruit was significantly less in the radurised fruits.

  15. THE IMPACT OF THE MCU LIFE EXTENSION SOLVENT ON DWPF GLASS FORMULATION EFFORTS

    Energy Technology Data Exchange (ETDEWEB)

    Peeler, D; Edwards, T

    2011-03-24

    As a part of the Actinide Removal Process (ARP)/Modular Caustic Side Solvent Extraction Unit (MCU) Life Extension Project, a next generation solvent (NG-CSSX), a new strip acid, and modified monosodium titanate (mMST) will be deployed. The strip acid will be changed from dilute nitric acid to dilute boric acid (0.01 M). Because of these changes, experimental testing with the next generation solvent and mMST is required to determine the impact of these changes in 512-S operations as well as Chemical Process Cell (CPC), Defense Waste Processing Facility (DWPF) glass formulation activities, and melter operations at DWPF. To support programmatic objectives, the downstream impacts of the boric acid strip effluent (SE) to the glass formulation activities and melter operations are considered in this study. More specifically, the impacts of boric acid additions to the projected SB7b operating windows, potential impacts to frit production temperatures, and the potential impact of boron volatility are evaluated. Although various boric acid molarities have been reported and discussed, the baseline flowsheet used to support this assessment was 0.01M boric acid. The results of the paper study assessment indicate that Frit 418 and Frit 418-7D are robust to the implementation of the 0.01M boric acid SE into the SB7b flowsheet (sludge-only or ARP-added). More specifically, the projected operating windows for the nominal SB7b projections remain essentially constant (i.e., 25-43 or 25-44% waste loading (WL)) regardless of the flowsheet options (sludge-only, ARP added, and/or the presence of the new SE). These results indicate that even if SE is not transferred to the Sludge Receipt and Adjustment Tank (SRAT), there would be no need to add boric acid (from a trim tank) to compositionally compensate for the absence of the boric acid SE in either a sludge-only or ARP-added SB7b flowsheet. With respect to boron volatility, the Measurement Acceptability Region (MAR) assessments also

  16. Deterioration and shelf-life extension of fish and fishery products by modified atmosphere packaging

    Directory of Open Access Journals (Sweden)

    Payap Masniyom

    2011-04-01

    Full Text Available Fish and fishery products have been recognized as a nutrition source due to their high protein content. Moreover, theycontain considerable amount of unsaturated fatty acids, especially omega-3 fatty acids, which are regarded as preventivecompounds. However, shelf-life of seafood is limited by biochemical and microbiological changes. Modified atmospherepackaging (MAP is widely used for minimally processed fishery products including fresh meat for retarding microbial growthand enzymatic spoilage. CO2, O2, and N2 are most often used in MAP. CO2 enriched atmosphere inhibits the autolyticdegradation of fish muscle during storage. However, high levels of CO2 negatively affect product quality, especially by increasingdrip loss and altering texture. Development of satisfactory methods for shelf-life extension that ensure qualitymaintenance of products with minimum loss has drawn the attention of food technologists. The application of MAP andcombination process in seafood is a promising preservation method to extend the shelf-life of fish and fishery products.

  17. Sensory acceptability of squid rings gamma irradiated for shelf-life extension

    Science.gov (United States)

    Tomac, Alejandra; Cova, María C.; Narvaiz, Patricia; Yeannes, María I.

    2017-01-01

    The feasibility of extending the shelf-life of a squid product by gamma irradiation was analyzed. Illex argentinus rings were irradiated at 4 and 8 kGy; and stored at 4±1 °C during 77 days. No mesophilic bacteria, enterobacteriaceae and coliforms were detected in irradiated rings during storage. Psychrotrophic bacteria were significantly reduced by irradiation; their counts were fitted to a growth model which was further used for shelf-life estimations: 3 and 27 days for 0 and 4 kGy, respectively. Initially, non-irradiated as well as irradiated rings had very good sensory scores. The overall acceptability of 4 and 8 kGy rings did not decrease during 27 and 64 days, respectively, while control samples spoiled after 3 days. A radiation dose range for squid rings preservation was defined, which attained the technological shelf-life extension objective, without impairing sensory quality.

  18. 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans.

    Science.gov (United States)

    Chondrogianni, Niki; Georgila, Konstantina; Kourtis, Nikos; Tavernarakis, Nektarios; Gonos, Efstathios S

    2015-02-01

    Protein homeostasis (proteostasis) is one of the nodal points that need to be preserved to retain physiologic cellular/organismal balance. The ubiquitin-proteasome system (UPS) is responsible for the removal of both normal and damaged proteins, with the proteasome being the downstream effector. The proteasome is the major cellular protease with progressive impairment of function during aging and senescence. Despite the documented age-retarding properties of proteasome activation in various cellular models, simultaneous enhancement of the 20S core proteasome content, assembly, and function have never been reported in any multicellular organism. Consequently, the possible effects of the core proteasome modulation on organismal life span are elusive. In this study, we have achieved activation of the 20S proteasome at organismal level. We demonstrate enhancement of proteasome levels, assembly, and activity in the nematode Caenorhabditis elegans, resulting in life span extension and increased resistance to stress. We also provide evidence that the observed life span extension is dependent on the transcriptional activity of Dauer formation abnormal/Forkhead box class O (DAF-16/FOXO), skinhead-1 (SKN-1), and heat shock factor-1 (HSF-1) factors through regulation of downstream longevity genes. We further show that the reported beneficial effects are not ubiquitous but they are dependent on the genetic context. Finally, we provide evidence that proteasome core activation might be a potential strategy to minimize protein homeostasis deficiencies underlying aggregation-related diseases, such as Alzheimer's disease (AD) or Huntington's disease (HD). In summary, this is the first report demonstrating that 20S core proteasome up-regulation in terms of both content and activity is feasible in a multicellular eukaryotic organism and that in turn this modulation promotes extension of organismal health span and life span.

  19. 可扩展操作系统设计方法%A Design Methodology for Extensible Operating Systems

    Institute of Scientific and Technical Information of China (English)

    施笑安; 周兴社; 林奕; 王继晖

    2002-01-01

    Operating systems research has traditionally consisted of adding functions to the operating system or inventing and study new implementations. Regardless of the research goal, the single constant has been that the size and complexity of operating system increase over time. As a result, operating systems become the most single complex piece of software in a computer system. Today's operating system research is aimed at finding new ways to construct the operating system in order to increase its flexibility, allowing it to adapt to change in designing such extensible systems and the array of choices facing the operating system designer. We discuss such question for describing extensible operating systems and then advance four key design point for extensible operating systems, we analyze and argue each point that relate to different extensible technology. Provide scientific methodology for Operaring systems research or development.

  20. Multipoint Lax operator algebras. Almost-graded structure and central extensions

    OpenAIRE

    Schlichenmaier, Martin

    2013-01-01

    Recently, Lax operator algebras appeared as a new class of higher genus current type algebras. Based on I.Krichever's theory of Lax operators on algebraic curves they were introduced by I. Krichever and O. Sheinman. These algebras are almost-graded Lie algebras of currents on Riemann surfaces with marked points (in-points, out-points, and Tyurin points). In a previous joint article of the author with Sheinman the local cocycles and associated almost-graded central extensions are classified in...

  1. Multipoint Lax operator algebras: almost-graded structure and central extensions

    Energy Technology Data Exchange (ETDEWEB)

    Schlichenmaier, M [University of Luxembourg (Luxembourg)

    2014-05-31

    Recently, Lax operator algebras appeared as a new class of higher genus current-type algebras. Introduced by Krichever and Sheinman, they were based on Krichever's theory of Lax operators on algebraic curves. These algebras are almost-graded Lie algebras of currents on Riemann surfaces with marked points (in-points, out-points and Tyurin points). In a previous joint article with Sheinman, the author classified the local cocycles and associated almost-graded central extensions in the case of one in-point and one out-point. It was shown that the almost-graded extension is essentially unique. In this article the general case of Lax operator algebras corresponding to several in- and out-points is considered. As a first step they are shown to be almost-graded. The grading is given by splitting the marked points which are non-Tyurin points into in- and out-points. Next, classification results both for local and bounded cocycles are proved. The uniqueness theorem for almost-graded central extensions follows. To obtain this generalization additional techniques are needed which are presented in this article. Bibliography: 30 titles.

  2. Multipoint Lax operator algebras: almost-graded structure and central extensions

    Science.gov (United States)

    Schlichenmaier, M.

    2014-05-01

    Recently, Lax operator algebras appeared as a new class of higher genus current-type algebras. Introduced by Krichever and Sheinman, they were based on Krichever's theory of Lax operators on algebraic curves. These algebras are almost-graded Lie algebras of currents on Riemann surfaces with marked points (in-points, out-points and Tyurin points). In a previous joint article with Sheinman, the author classified the local cocycles and associated almost-graded central extensions in the case of one in-point and one out-point. It was shown that the almost-graded extension is essentially unique. In this article the general case of Lax operator algebras corresponding to several in- and out-points is considered. As a first step they are shown to be almost-graded. The grading is given by splitting the marked points which are non-Tyurin points into in- and out-points. Next, classification results both for local and bounded cocycles are proved. The uniqueness theorem for almost-graded central extensions follows. To obtain this generalization additional techniques are needed which are presented in this article. Bibliography: 30 titles.

  3. Servicemembers' Group Life Insurance--Veterans' Group Life Insurance regulation update--ABO, VGLI application, SGLI 2-year disability extension. Final rule.

    Science.gov (United States)

    2014-07-31

    This document amends the Department of Veterans Affairs (VA) insurance regulations concerning Servicemembers' Group Life Insurance (SGLI) to reflect the statutory provisions of the Veterans' Benefits Act of 2010, which became law on October 13, 2010, and resulted in the need for amendments to change the SGLI Disability Extension period from 1 year to 2 years in duration; provide SGLI Traumatic Injury Protection (TSGLI) retroactive coverage effective from October 7, 2001, for all qualifying injuries regardless of the geographic location and military operation in which the injuries were incurred; and remove the SGLI and Veterans' Group Life Insurance (VGLI) Accelerated Benefits Option (ABO) discount rate. This rule also clarifies that ``initial premium'' refers to ``initial Veterans' Group Life Insurance premium,'' updates the current address of the Office of Servicemembers' Group Life Insurance (OSGLI), managed by Prudential Insurance Company of America, to reflect where the ABO application is mailed for processing, and corrects the OSGLI phone number. Finally, this rule removes the ABO application form from the regulation, and it corrects and clarifies language concerning the VGLI application period that was inadvertently incorrectly modified in a prior amendment of the regulations.

  4. 76 FR 67480 - Standard on Commercial Diving Operations; Extension of the Office of Management and Budget's (OMB...

    Science.gov (United States)

    2011-11-01

    ... Occupational Safety and Health Administration Standard on Commercial Diving Operations; Extension of the Office of Management and Budget's (OMB) Approval of Information Collection (Paperwork) Requirements AGENCY... requirements specified in the Commercial Diving Operations Standard (29 CFR part 1910, subpart T)....

  5. B61 Mod 12 Life Extension Program Tailkit Assembly (B61 Mod 12 LEP TKA)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-468 B61 Mod 12 Life Extension Program Tailkit Assembly (B61 Mod 12 LEP TKA) As of FY 2017...President’s Budget Defense Acquisition Management Information Retrieval (DAMIR) March 23, 2016 10:38:20 UNCLASSIFIED B61 Mod 12 LEP TKA December 2015...Unit Cost B61 Mod 12 LEP TKA December 2015 SAR March 23, 2016 10:38:20 UNCLASSIFIED 3 PB - President’s Budget PE - Program Element PEO - Program

  6. Modified Atmosphere Systems and Shelf Life Extension of Fish and Fishery Products

    Directory of Open Access Journals (Sweden)

    Christina A. Mireles DeWitt

    2016-06-01

    Full Text Available This review aims at summarizing the findings of studies published over the past 15 years on the application of modified atmosphere (MA systems for shelf life extension of fish and fishery products. This review highlights the importance of CO2 in the preservation of seafood products, and underscores the benefits of combining MA technology with product storage in the superchilled temperature range. It is generally accepted that MA technology cannot improve product quality and should not be utilized as a substitute for good sanitation and strict temperature control. Benefits derived from application of MA, however, can significantly impact preservation of product quality and it subsequent shelf-life. For this reason, this review is the first of its kind to propose detailed handling and quality guidelines for fresh fish to realize the maximum benefit of MA technology.

  7. Modified Atmosphere Systems and Shelf Life Extension of Fish and Fishery Products.

    Science.gov (United States)

    DeWitt, Christina A Mireles; Oliveira, Alexandra C M

    2016-06-28

    This review aims at summarizing the findings of studies published over the past 15 years on the application of modified atmosphere (MA) systems for shelf life extension of fish and fishery products. This review highlights the importance of CO₂ in the preservation of seafood products, and underscores the benefits of combining MA technology with product storage in the superchilled temperature range. It is generally accepted that MA technology cannot improve product quality and should not be utilized as a substitute for good sanitation and strict temperature control. Benefits derived from application of MA, however, can significantly impact preservation of product quality and it subsequent shelf-life. For this reason, this review is the first of its kind to propose detailed handling and quality guidelines for fresh fish to realize the maximum benefit of MA technology.

  8. An extensible operating system design for large-scale parallel machines.

    Energy Technology Data Exchange (ETDEWEB)

    Riesen, Rolf E.; Ferreira, Kurt Brian

    2009-04-01

    Running untrusted user-level code inside an operating system kernel has been studied in the 1990's but has not really caught on. We believe the time has come to resurrect kernel extensions for operating systems that run on highly-parallel clusters and supercomputers. The reason is that the usage model for these machines differs significantly from a desktop machine or a server. In addition, vendors are starting to add features, such as floating-point accelerators, multicore processors, and reconfigurable compute elements. An operating system for such machines must be adaptable to the requirements of specific applications and provide abstractions to access next-generation hardware features, without sacrificing performance or scalability.

  9. Towards gaining renewed balance in life after operable lung cancer

    DEFF Research Database (Denmark)

    Missel, Malene

    Background. Studies involving groups of patients with operable non-small cell lung cancer (NSCLC) provide valuable knowledge on symptoms, quality of life and needs using questionnaires, but knowledge of the perspective of patients diagnosed with lung cancer and the significance of the illness...... and its treatment on their daily lives is scant. Moreover qualitative evidence on patient experiences of participation in rehabilitation is lacking. Objectives. To explore the lived experiences of patients with operable lung cancer in daily life at ‘four critical moments’ during a ‘standard’ illness...... cancer. Methods. Study participants were divided into three samples of patients with operable lung cancer referred for surgery at the Department of Thoracic Surgery, the Heart Centre, Rigshospitalet, University of Copenhagen. Samples I and II involved an exploration of patients’ lived experiences during...

  10. Extension theorems for linear operators on $L_\\infty$ and application to price systems

    CERN Document Server

    Bion-Nadal, Jocelyne

    2011-01-01

    In an $L_\\infty$-framework, we present a few extension theorems for linear operators. We focus the attention on majorant preserving and sandwich preserving types of extensions. These results are then applied to the study of price systems derived by a reasonable restriction of the class of equivalent martingale measures applicable. First we consider equivalent martingale measures with bounds on densities and the corresponding prices bounded by linear minorant and majorant. Then we consider prices bounded by bid-ask dynamics. Finally we study price systems consistent with no-good-deal pricing measures for given bounds on the Sharpe ratio. Within this study we introduce the definition of dynamic no-good-deal pricing measure.

  11. Life Extension Methodologies and Risk-Based Inspection in the Management of Fracture Critical Aeroengine Components

    Science.gov (United States)

    2003-02-01

    stresses. The life-to-first- crack distributions and the propagation lives obtained in the nickel-base superalloys used in aeroengine discs appear to...aircraft. Turbine and compressor discs and shafts are identified as the major fracture critical components. They experience extreme thermo- mechanical...airworthiness, and integrity of fracture components such as discs and shafts throughout their service operation. Such events are non-random and hence

  12. Shelf-life extension of minimally processed carrots by gaseous chlorine dioxide.

    Science.gov (United States)

    Gómez-López, V M; Devlieghere, F; Ragaert, P; Debevere, J

    2007-05-10

    Chlorine dioxide (ClO(2)) gas is a strong oxidizing and sanitizing agent that has a broad and high biocidal effectiveness and big penetration ability; its efficacy to prolong the shelf-life of a minimally processed (MP) vegetable, grated carrots (Daucus carota L.), was tested in this study. Carrots were sorted, their ends removed, hand peeled, cut, washed, spin dried and separated in 2 portions, one to be treated with ClO(2) gas and the other to remain untreated for comparisons. MP carrots were decontaminated in a cabinet at 91% relative humidity and 28 degrees C for up to 6 min, including 30 s of ClO(2) injection to the cabinet, then stored under equilibrium modified atmosphere (4.5% O(2), 8.9% CO(2), 86.6% N(2)) at 7 degrees C for shelf-life studies. ClO(2) concentration in the cabinet rose to 1.33 mg/l after 30 s of treatment, and then fell to nil before 6 min. The shelf-life study included: O(2) and CO(2) headspace concentrations, microbiological quality (mesophilic aerobic bacteria, psychrotrophs, lactic acid bacteria, and yeasts), sensory quality (odour, flavour, texture, overall visual quality, and white blushing), and pH. ClO(2) did not affect respiration rate of MP carrots significantly (alphacarrots was not impaired significantly (alphaview. The shelf-life extension was limited to one day due to the restricted effect of the ClO(2) treatment on yeast counts. Nevertheless, ClO(2) seems to be a promising alternative to prolong the shelf-life of grated carrots.

  13. Exploring the Gap for Effective Extension of Professional Active Life in Europe

    Science.gov (United States)

    Leonard, Will; Afsarmanesh, Hamideh; Msanjila, Simon S.; Playfoot, Jim

    Extending Professional Active Life (ePAL [2]) of elder people in Europe is affected by a number of factors in the market and society, which have the potential to either positively and negatively influence it. Current practices indicate that the European society, while started to act on this subject, is still slow to recognize the rationale behind and importance of fully supporting the extension of active professional life of seniors. Similarly, the capacity of the service sector to fully support the involvement of seniors in economical activities is at present limited, given the huge number of these seniors in different countries who need to be mobilized. This paper seeks to highlight the identified gaps related to effective mechanisms by which Europe can support its willing senior professionals to remain active. The study on gap identification addresses relevant technological, social, and organizational factors and external influences which have the potential to impact successful future life of elderly population. It also presents the methodology that is applied in our study to identify and analyze the gaps between the current practices in this area, the so-called baseline [2], and the desired future for this area as inspired in the ePAL vision [1] addressed in other research.

  14. Bio-fortification and shelf-life extension of idli batter using curry leaves (Murraya koenigii).

    Science.gov (United States)

    Chelliah, R; Ramakrishnan, S R; Premkumar, D; Antony, U

    2016-06-01

    Among several traditional foods of India, idli is one of the most popular and commonly consumed steamed products. A new method of adding Murraya koenigii (curry leaves) to idli batter as a vehicle for fortification and extension of shelf-life has been developed. Dried curry leaves powder was incorporated with other ingredients like rice and dehusked black gram in different proportions to optimize the most palatable formulation. Rate of fermentation and microbial changes in the batter; nutritional qualities, texture and sensory properties of the prepared product were assessed. Incorporation of curry leaves powder (5 %) in idli batter increased the shelf-life and also increased the flavour, texture and appearance of the idli. The calcium content of the prepared idli was 10 times more than that of the control idli, while dietary fiber content increased by 18.6 %. Anti-microbial activity of the curry leaves in idli batter extended the shelf-life from 2 to 5 days when stored at 30 °C.

  15. Study of Thorium-Plutonium Fuel for Possible Operating Cycle Extension in PWRs

    Directory of Open Access Journals (Sweden)

    Klara Insulander Björk

    2013-01-01

    Full Text Available Computer simulations have been carried out to investigate the possibility of extending operating cycle length in the Pressurised Water Reactor Ringhals 3 by the use of thorium-plutonium oxide fuel. The calculations have been carried out using tools and methods that are normally employed for reload design and safety evaluation in Ringhals 3. The 3-batch reload scheme and the power level have been kept unchanged, and a normal uranium oxide fuel assembly designed for a 12-month operating cycle in this reactor is used as a reference. The use of plutonium as the fissile component reduces the worth of control rods and soluble boron, which makes it necessary to modify the control systems. The delayed neutron fraction is low compared with the reference, but simulations and qualitative assessments of relevant transients indicate that the reactor could still be operated safely. Differences in reactivity coefficients are mainly beneficial for the outcome of transient simulations for the thorium based fuel. A 50% extension of the current 12-month operating cycle length should be possible with thorium-plutonium mixed oxide fuel, given an upgrade of the control systems. More detailed simulations have to be carried out for some transients in order to confirm the qualitative reasoning presented.

  16. Ensemble Kalman Filtering with Residual Nudging: An Extension to State Estimation Problems with Nonlinear Observation Operators

    KAUST Repository

    Luo, Xiaodong

    2014-10-01

    The ensemble Kalman filter (EnKF) is an efficient algorithm for many data assimilation problems. In certain circumstances, however, divergence of the EnKF might be spotted. In previous studies, the authors proposed an observation-space-based strategy, called residual nudging, to improve the stability of the EnKF when dealing with linear observation operators. The main idea behind residual nudging is to monitor and, if necessary, adjust the distances (misfits) between the real observations and the simulated ones of the state estimates, in the hope that by doing so one may be able to obtain better estimation accuracy. In the present study, residual nudging is extended and modified in order to handle nonlinear observation operators. Such extension and modification result in an iterative filtering framework that, under suitable conditions, is able to achieve the objective of residual nudging for data assimilation problems with nonlinear observation operators. The 40-dimensional Lorenz-96 model is used to illustrate the performance of the iterative filter. Numerical results show that, while a normal EnKF may diverge with nonlinear observation operators, the proposed iterative filter remains stable and leads to reasonable estimation accuracy under various experimental settings.

  17. Overview of United States Department of Energy activities to support life extension of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, D.L. [USDOE Assistant Secretary for Nuclear Energy, Washington, DC (United States). Office of LWR Safety and Technology; Rosinski, S.T. [Sandia National Labs., Albuquerque, NM (United States)

    1993-11-01

    Today, 109 nuclear power plants provide over 20 percent of the electrical energy generated in the US The operating license of the first of these plants will expire in the year 2000; one-third of the operating licenses will expire by 2010 and the remaining plant licenses are scheduled to expire by 2033. The National Energy Strategy assumes that 70 percent of these plants will continue to operate beyond their current license expiration to assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth. In order to preserve this energy resource in the US three major tasks must be successfully completed: establishment of regulations, technical standards, and procedures for the preparation and review of a license renewal application; development, verification, and validation of technical criteria and bases for monitoring, refurbishing, and/or replacing plant equipment; and demonstration of the regulatory process. Since 1985, the US Department of Energy (DOE) has been working with the nuclear industry and the US Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of nuclear power plants through the renewal of operating licenses. This paper focuses primarily on DOE`s Plant Lifetime Improvement (PLIM) Program efforts to develop the technical criteria and bases for effective aging management and lifetime improvement for continued operation of nuclear power plants. This paper describes current projects to resolve generic technical issues in the principal areas of reactor pressure vessel (RPV) integrity, fatigue, and environmental qualification (EQ).

  18. Community perceptions on the significant extension of life: an exploratory study among urban adults in Brisbane, Australia.

    Science.gov (United States)

    Underwood, Mair; Bartlett, Helen P; Partridge, Brad; Lucke, Jayne; Hall, Wayne D

    2009-02-01

    Some researchers in the field of ageing claim that significant extension of the human lifespan will be possible in the near future. While many of these researchers have assumed that the community will welcome this technology, there has been very little research on community attitudes to life extension. This paper presents the results of an in-depth qualitative study of community attitudes to life extension across age groups and religious boundaries. There were 57 individual interviews, and 8 focus groups (totalling 72 focus group participants) conducted with community members in Brisbane, Australia. Community attitudes to life extension were more varied and complex than have been assumed by some biogerontologists and bioethicists. While some participants would welcome the opportunity to extend their lives others would not even entertain the possibility. This paper details these differences of opinion and reveals contrasting positions that reflect individualism or social concern among community members. The findings also highlight the relationship between Christianity, in particular belief in an afterlife, and attitudes to life extension technology. Overall, the study raises questions about the relationship between interest in life extension, the medicalisation of ageing and the increasing acceptability of enhancement technologies that need to be addressed in more representative samples of the community.

  19. [Quality of life and sexual function of cervical cancer patients following radical hysterectomy and vaginal extension].

    Science.gov (United States)

    Ye, Shuang; Yang, Jiaxin; Cao, Dongyan; Zhu, Lan; Lang, Jinghe; Shen, Keng

    2014-08-01

    To investigate the quality of life and sexual function of cervical cancer patients following radical hysterectomy (RH) and vaginal extension. Case-control and questionnaire- based method was employed in this study. Thirty-one patients of early-stage (I b1-I b2) cervical cancer who had undergone vaginal extension following classic RH in Peking Union Medical College Hospital from December 2008 to September 2012 were included in study group, while 28 patients with matching factors and RH only during the same period were allocated to control group. There was no significant difference between two groups in terms of clinical and demographic variables including age at diagnosis, tumor stage and follow-up time (P > 0.05). Patients were assessed retrospectively by validated self-reported questionnaires the European Organization for Research and Treatment of Cancer Cervix Cancer Module Questionnaire (EORTC QLQ-CX24) mainly for quality of life and sexual function for cervical cancer patients; the Sexual Function and Vaginal Changes Questionnaire (SVQ) further investigates sexual function and vaginal changes of patients with gynecologic malignancy at least 6 months after treatment. Vaginal length acquired by pelvic examination by gynecologic oncologists during follow-up visits was (10.0 ± 1.3) cm and (5.9 ± 1.0)cm in study group and control group respectively (P = 0.000). Sixty-eight percent (21/31) of cases in study group and 64% (18/28) of cases in control group had resumed sexual activity at the time of interview, and the time interval between treatment and regular sexual activity was mean 6 months (range 3-20 months) and mean 5 months (range 1-12 months) in study and control group respectively, in which there was not statistical significance (P > 0.05). No difference was observed regarding pelvic floor symptoms (P > 0.05) while difficulty emptying bladder, incomplete emptying and constipation were most commonly reported. Both group presented with hypoactive sexual desire

  20. Study on shelf life extension of papayas irradiated by /sup 60/Co gamma-rays

    Energy Technology Data Exchange (ETDEWEB)

    Chang, M.S.; Chen, M.D.; Lin, C.T.; Fu, Y.K.

    1984-11-01

    Papayas are one of the main fresh fruits in Taiwan area. Papaya fruits were treated with hot water to pasteurize peels followed by /sup 60/Co gamma-ray irradiation to extend the ripening time. The purpose of synergetic methods is to extend the shelf life of papaya fruits. This experiment was carried out by seven treatments, which were: (1) control group, (2) hot water treatment only, (3) hot water treatment with a 25 krad ..gamma..-irradiation, (4) hot water treatment with a 50 krad ..gamma..-irradiation, (5) hot water treatment with a 75 krad ..gamma..-irradiation, (6) 75 krad ..gamma..-irradiation only, and (7) hot water treatment with a 100 krad ..gamma..-irradiation. The items of observation were: surface yellowing, surface decaying, quality of texture, and length of period lasted after irradiation for 50% marketable papayas. The results of this study showed that a shelf-life extension of six days could be obtained for papayas subjected to hot water (50 to 55/sup 0/C) treatment and a 100 krad irradiation. 3 refs., 2 figs., 2 tabs.

  1. Shelf life extension of whole Norway lobster Nephrops norvegicus using modified atmosphere packaging.

    Science.gov (United States)

    Gornik, Sebastian G; Albalat, Amaya; Theethakaew, Chonchanok; Neil, Douglas M

    2013-11-01

    Once a nuisance by-catch, today the Norway lobster (Nephrops norvegicus) is a valuable UK fisheries commodity. Unfortunately, the species is very susceptible to quality deterioration post harvest as it quickly develops black spots and also spoils rapidly due to bacterial growth. Treatment with chemicals can stop the blackening and carefully monitored cold storage can result in a sensory shelf life of up to 6.5 days. The high susceptibility to spoilage greatly restricts the extent to which N. norvegicus can be distributed to retailers and displayed for sale. The application of modified atmosphere (MA) could be extremely beneficial, allowing the chilled product to stay fresh for a long period of time, thus ensuring higher sales. In the present study, we identified a gas mix for the MA packaging (MAP) of whole N. norvegicus lobster into 200 g retail packs. Our results show that a shelf life extension to 13 days can be achieved when retail packs are stored in MAP at 1 °C. Effectiveness of the MAP was evaluated by using a newly developed QIM for MA-packaged whole N. norvegicus and also by analyzing bacterial plate counts. Changes in the microflora and effects of different storage temperatures on the quality of the MA packs are also presented. The main specific spoilage organism (SSO) of modified atmosphere packaged Norway lobster is Photobacterium phosphoreum.

  2. Protein HESylation for half-life extension: synthesis, characterization and pharmacokinetics of HESylated anakinra.

    Science.gov (United States)

    Liebner, Robert; Mathaes, Roman; Meyer, Martin; Hey, Thomas; Winter, Gerhard; Besheer, Ahmed

    2014-07-01

    Half-life extension (HLE) is becoming an essential component of the industrial development of small-sized therapeutic peptides and proteins. HESylation(®) is a HLE technology based on coupling drug molecules to the biodegradable hydroxyethyl starch (HES). In this study, we report on the synthesis, characterization and pharmacokinetics of HESylated anakinra, where anakinra was conjugated to propionaldehyde-HES using reductive amination, leading to a monoHESylated protein. Characterization using size exclusion chromatography and dynamic light scattering confirmed conjugation and the increase in molecular size, while Fourier transform infrared spectroscopy showed that the secondary structure of the conjugate was not affected by coupling. Meanwhile, microcalorimetry and aggregation studies showed a significant increase in protein stability. Surface plasmon resonance and microscale thermophoresis showed that the conjugate retained its nanomolar affinity, and finally, the pharmacokinetics of the HESylated protein exhibited a 6.5-fold increase in the half-life, and a 45-fold increase in the AUC. These results indicate that HESylation(®) is a promising HLE technology.

  3. Shelf life extension of minimally processed ready-to-cook (RTC) cabbage by gamma irradiation.

    Science.gov (United States)

    Banerjee, Aparajita; Chatterjee, Suchandra; Variyar, Prasad S; Sharma, Arun

    2016-01-01

    Gamma irradiation (0.5-2.5 kGy) in combination with low temperature (4-15 °C) storage was attempted to increase shelf life of ready-to-cook shredded cabbage wrapped in cling films. A maximum extension in shelf life of 8 days, while retaining the microbial and sensory quality, was obtained with an irradiation dose of 2 kGy and storage at 10 °C. Gamma irradiation also inhibited browning of shredded cabbage at their cut edges resulting in enhanced visual appeal. An increase in total antioxidant activity was observed with respect to DPPH and hydroxyl radical scavenging ability while the nitric oxide radical scavenging activity and ferric reducing property remained unaffected with irradiation. Total phenolic, flavonoid and vitamin C content remained unchanged due to irradiation. No significant migration of additives from cling films into stimulant water was observed up to a radiation dose of 2 kGy thus demonstrating the feasibility of such films for above applications.

  4. Model of environmental life cycle assessment for coal mining operations

    Energy Technology Data Exchange (ETDEWEB)

    Burchart-Korol, Dorota, E-mail: dburchart@gig.eu; Fugiel, Agata, E-mail: afugiel@gig.eu; Czaplicka-Kolarz, Krystyna, E-mail: kczaplicka@gig.eu; Turek, Marian, E-mail: mturek@gig.eu

    2016-08-15

    This paper presents a novel approach to environmental assessment of coal mining operations, which enables assessment of the factors that are both directly and indirectly affecting the environment and are associated with the production of raw materials and energy used in processes. The primary novelty of the paper is the development of a computational environmental life cycle assessment (LCA) model for coal mining operations and the application of the model for coal mining operations in Poland. The LCA model enables the assessment of environmental indicators for all identified unit processes in hard coal mines with the life cycle approach. The proposed model enables the assessment of greenhouse gas emissions (GHGs) based on the IPCC method and the assessment of damage categories, such as human health, ecosystems and resources based on the ReCiPe method. The model enables the assessment of GHGs for hard coal mining operations in three time frames: 20, 100 and 500 years. The model was used to evaluate the coal mines in Poland. It was demonstrated that the largest environmental impacts in damage categories were associated with the use of fossil fuels, methane emissions and the use of electricity, processing of wastes, heat, and steel supports. It was concluded that an environmental assessment of coal mining operations, apart from direct influence from processing waste, methane emissions and drainage water, should include the use of electricity, heat and steel, particularly for steel supports. Because the model allows the comparison of environmental impact assessment for various unit processes, it can be used for all hard coal mines, not only in Poland but also in the world. This development is an important step forward in the study of the impacts of fossil fuels on the environment with the potential to mitigate the impact of the coal industry on the environment. - Highlights: • A computational LCA model for assessment of coal mining operations • Identification of

  5. U.S. Nuclear Weapons Modernization - the Stockpile Life Extension Program

    Science.gov (United States)

    Cook, Donald

    2016-03-01

    required to assess many changes at once, or confidence in these weapons would be reduced. The strategy and details of the U.S. Stockpile Life Extension Program will be described in this talk. In brief, the strategy is to reduce the number of weapons in the stockpile while increasing confidence in the weapons that remain and, where possible, increase their safety, increase their security, and reduce their nuclear material quantities and yields. A number of ``myths'' pertaining to nuclear weapons, the SSP, and the Stockpile Life Extension Program will be explored.

  6. Extension of Boolean algebra by a Bayesian operator: application to the definition of a Deterministic Bayesian Logic

    CERN Document Server

    Dambreville, Frederic

    2011-01-01

    This work contributes to the domains of Boolean algebra and of Bayesian probability, by proposing an algebraic extension of Boolean algebras, which implements an operator for the Bayesian conditional inference and is closed under this operator. It is known since the work of Lewis (Lewis' triviality) that it is not possible to construct such conditional operator within the space of events. Nevertheless, this work proposes an answer which complements Lewis' triviality, by the construction of a conditional operator outside the space of events, thus resulting in an algebraic extension. In particular, it is proved that any probability defined on a Boolean algebra may be extended to its algebraic extension in compliance with the multiplicative definition of the conditional probability. In the last part of this paper, a new \\emph{bivalent} logic is introduced on the basis of this algebraic extension, and basic properties are derived.

  7. Model of environmental life cycle assessment for coal mining operations.

    Science.gov (United States)

    Burchart-Korol, Dorota; Fugiel, Agata; Czaplicka-Kolarz, Krystyna; Turek, Marian

    2016-08-15

    This paper presents a novel approach to environmental assessment of coal mining operations, which enables assessment of the factors that are both directly and indirectly affecting the environment and are associated with the production of raw materials and energy used in processes. The primary novelty of the paper is the development of a computational environmental life cycle assessment (LCA) model for coal mining operations and the application of the model for coal mining operations in Poland. The LCA model enables the assessment of environmental indicators for all identified unit processes in hard coal mines with the life cycle approach. The proposed model enables the assessment of greenhouse gas emissions (GHGs) based on the IPCC method and the assessment of damage categories, such as human health, ecosystems and resources based on the ReCiPe method. The model enables the assessment of GHGs for hard coal mining operations in three time frames: 20, 100 and 500years. The model was used to evaluate the coal mines in Poland. It was demonstrated that the largest environmental impacts in damage categories were associated with the use of fossil fuels, methane emissions and the use of electricity, processing of wastes, heat, and steel supports. It was concluded that an environmental assessment of coal mining operations, apart from direct influence from processing waste, methane emissions and drainage water, should include the use of electricity, heat and steel, particularly for steel supports. Because the model allows the comparison of environmental impact assessment for various unit processes, it can be used for all hard coal mines, not only in Poland but also in the world. This development is an important step forward in the study of the impacts of fossil fuels on the environment with the potential to mitigate the impact of the coal industry on the environment.

  8. Leveraging Available Data to Support Extension of Transportation Packages Service Life

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, K.; Abramczyk, G.; Bellamy, S.; Daugherty, W.; Hackney, B.; Hoffman, E.; Skidmore, E.; Stefek, T.

    2012-06-12

    Data obtained from testing shipping package materials have been leveraged to support extending the service life of select shipping packages while in nuclear materials transportation. Increasingly, nuclear material inventories are being transferred to an interim storage location where they will reside for extended periods of time. Use of a shipping package to store nuclear materials in an interim storage location has become more attractive for a variety of reasons. Shipping packages are robust and have a qualified pedigree for their performance in normal operation and accident conditions within the approved shipment period and storing nuclear material within a shipping package results in reduced operations for the storage facility. However, the shipping package materials of construction must maintain a level of integrity as specified by the safety basis of the storage facility through the duration of the storage period, which is typically well beyond the one year transportation window. Test programs have been established to obtain aging data on materials of construction that are the most sensitive/susceptible to aging in certain shipping package designs. The collective data are being used to support extending the service life of shipping packages in both transportation and storage.

  9. Technological evaluation for the extension of the operation license to the nuclear power plant of Laguna Verde; Evaluacion tecnologica para la extension de la licencia de operacion de la Central Nucleoelectrica Laguna Verde

    Energy Technology Data Exchange (ETDEWEB)

    Arganis J, C. R.; Medina A, A. L., E-mail: carlos.arganis@inin.gob.m [ININ, Departamento de Tecnologia de Materiales, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-07-01

    At the present time one of the tendencies in the nuclear industry is the renovation of operation licenses of the nuclear power plants, with the purpose of prolonging their operation 20 years more than the time settled down in their original license, which is of 30 years for the case of the nuclear power plant of Laguna Verde. This allows the electric power generation for a major period of time and to a relatively low price, giving this way a bigger competitiveness to the power stations of nuclear power. However, to request the license extension of the nuclear power plant requires to get ready the documentation and necessary studies for: to maintain a high level of security, to optimize the operation, maintenance and service life of the structures, systems and components, to maintain an acceptable level of performance, to maximize the recovery of the investment about the service of the nuclear power plant and to preserve the sure conditions for a major operation period at the license time. This paper describes the studies conducted by the Materials Technology Department of the Instituto Nacional de Investigaciones Nucleares (ININ) to substantiate the required documentation for obtaining the extension of operating license of the nuclear power plant. These studies are focused mainly in the reactor pressure vessels of both units, as well as in the deposit of noble metals and the influence of the sludges (crud s) in this deposit. (Author)

  10. Shelf-life extension of refrigerated Mediterranean mullet (Mullus surmuletus) using modified atmosphere packaging.

    Science.gov (United States)

    Pournis, Nikolaos; Papavergou, Aikaterini; Badeka, Anastasia; Kontominas, Michael G; Savvaidis, Ioannis N

    2005-10-01

    The present work evaluated the quality and freshness characteristics and the effect of modified atmosphere packaging (MAP) on the shelf-life extension of refrigerated Mediterranean mullet using microbiological, biochemical, and sensory analyses. Fresh open sea red mullet (Mullus surmuletus) were packaged in four different atmospheres: M1, 10%/20%/70% (O2/ CO2/N2); M2, 10%/40%/50% (O2/CO2/N2); M3, 10%/60%/30% (O2/CO2/N2); identical fish samples were packaged in air. All fish were kept under refrigeration (4 +/- 0.5 degrees C) for 14 days. Of the three gas atmospheres, the 10%/40%/50% (M2) and 10%/ 60%/30% (M3) gas mixtures were the most effective for inhibiting growth of aerobic microflora in mullet samples until day 10 of refrigerated storage. H2S-producing bacteria and pseudomonads were part of the mullet microflora and their growth was partly inhibited under MAP conditions. Between these two bacterial groups, H2S-producing bacteria (including Shewanella putrefaciens) were dominant toward the end of the storage period, regardless of the packaging conditions. Brochothrix thermosphacta and lactic acid bacteria were found to be members of the final microbial flora of MAP and air-packaged mullet, whereas the Enterobacteriaceae population was lower than other bacterial groups. Of the chemical freshness indices determined, thiobarbituric acid values were variable in mullet samples irrespective of packaging conditions indicative of no specific oxidative rancidity trend. Based on sensorial data and aerobic plate count, trimethylamine nitrogen and total volatile basic nitrogen limit values in the range of ca. 15 to 23 and 52 to 60 mg N/100 g of fish muscle were obtained, respectively, for mullet packaged under modified atmosphere and air. Sensory analyses (odor and taste attributes) showed that the limit of sensorial acceptability was reached after ca. 6 days for the samples packaged in air, 8 days for the M1 and M3 samples, and after 10 days for the M2 samples. Respective

  11. Shelf life extension and sensory evaluation of birch tree sap using chemical preservatives

    Directory of Open Access Journals (Sweden)

    Maciej Bilek

    2016-10-01

    Full Text Available The aim of this study was to assess the stability of the birch tree sap, depending on the addition and concentration of two chemical factors, ie. potassium sorbate and acids: malic, citric or lactic. As in our previous studies we found that the optimal physical parameter to assess the stability of birch sap is turbidity measurement, we used turbidimeter for estimate the effectiveness of shelf life extending. Sensory evaluation was carried out by university sensory panel with 8 skilled people (students and teachers with pre-selection and basic training of sensory methodology. On the other hand artificial perception measurements were realized by electronic nose. Birch tree sap stability without addition of preservatives, both room temperature and refrigerated, is less than three days. The effectiveness of preservation of birch tree sap depends on the concentration of acids. Independently of storage temperature, samples that received stability during the whole one-month storage period, were those with potassium sorbate and three acids in the highest concentrations, ie. malic acid at 0.3%, citric acid at 0.5% and lactic acid at 0.5%. Unfortunately, concentrations of acids, which allow extension of shelf life at least for one month in a room temperature, are characterized by the worst sensory evaluation rating. Thus, they should be corrected by the use of additives for improving the flavor, such as fruit syrups or herbal extracts. On the other hand, additionally storage in a refrigerated conditions allows one-month-stability for the sample with the highest sensory evaluation rating, ie. with the addition of lactic acid at 0.1% and potassium sorbate, which taste not need to be corrected.

  12. 75 FR 17162 - Dipping and Coating Operations (Dip Tanks) Standard; Extension of the Office of Management and...

    Science.gov (United States)

    2010-04-05

    ... Occupational Safety and Health Administration Dipping and Coating Operations (Dip Tanks) Standard; Extension of the Office of Management and Budget's Approval of the Information Collection (Paperwork) Requirement... collection requirement specified in its Standard on Dipping and Coating Operations (Dip Tanks) (29 CFR...

  13. A study on the optimization of plant life extension and decommissioning for the improvement of economy in nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae In; Jung, K. J.; Chung, U. S.; Baik, S. T.; Park, S. K.; Lee, D. G.; Kim, H. R.; Park, B. Y

    2000-01-01

    Fundamentals on the plan, the national policy, the safety securities for the life extension of the nuclear power plant was established from the domestic/abroad documents and case studies in relation with the life extension and decommissioning of the nuclear power plant. Concerning the decommissioning of the nuclear power plant, the management according to decommissioning stages was analyzed by the investigation of the domestic/abroad standard of the decommissioning (decontamination. dismantling) technology and regulation. Moreover, the study on the cost estimation method has been carried out for the decommissioning of the nuclear power plant. (author)

  14. What reassurances do the community need regarding life extension? Evidence from studies of community attitudes and an analysis of film portrayals.

    Science.gov (United States)

    Underwood, Mair

    2014-04-01

    It is increasingly recognized that community attitudes impact on the research trajectory, entry, and reception of new biotechnologies. Yet biogerontologists have generally been dismissive of public concerns about life extension. There is some evidence that biogerontological research agendas have not been communicated effectively, with studies finding that most community members have little or no knowledge of life extension research. In the absence of knowledge, community members' attitudes may well be shaped by issues raised in popular portrayals of life extension (e.g., in movies). To investigate how popular portrayals of life extension may influence community attitudes, I conducted an analysis of 19 films depicting human life extension across different genres. I focussed on how the pursuit of life extension was depicted, how life extension was achieved, the levels of interest in life extension shown by characters in the films, and the experiences of extended life depicted both at an individual and societal level. This paper compares the results of this analysis with the literature on community attitudes to life extension and makes recommendations about the issues in which the public may require reassurance if they are to support and accept life extension technologies.

  15. Condition assessment and trending of condenser tube degradation for condenser life extension

    Science.gov (United States)

    Friant, C. Lee; Schlegel, Jennifer L.

    1995-05-01

    Eddy current testing (ET) is routinely used to assess tubing condition in heat exchangers at power plants. Generally, ET results provided by typical final report formats are not well- suited for facilitating condition assessments, especially when the component has a significant number of tubes. The main condenser at Calvert Cliffs Nuclear Power Plant (CCNPP) Unit #1 contains nearly 50,000 tubes. An accurate condition assessment based on 2,500 pages of final reports generated from a 100% condenser inspection in 1992 proved difficult, if not impossible, without some type of automated data management system. With the aid of a data management system, engineering recommendations, founded on database queries and graphics, can be made quickly and reliably. These displays effectively communicate information about overall condition, are helpful in making operating decisions, and aid in predicting future performance. Standard procedures for critical heat exchanger inspections require trending of indication growth over time to determine a rate of tube degradation. Specifically, for the 1994 ET inspection of CCNPP Unit #1 condenser, the size of indications were compared against their 1992 value to determine a mean growth rate. The results of these efforts are presented along with a discussion of how Baltimore Gas and Electric has used eddy current data to prolong the operating life of this condenser while ensuring leak tightness.

  16. Statistical and Probabilistic Extensions to Ground Operations' Discrete Event Simulation Modeling

    Science.gov (United States)

    Trocine, Linda; Cummings, Nicholas H.; Bazzana, Ashley M.; Rychlik, Nathan; LeCroy, Kenneth L.; Cates, Grant R.

    2010-01-01

    NASA's human exploration initiatives will invest in technologies, public/private partnerships, and infrastructure, paving the way for the expansion of human civilization into the solar system and beyond. As it is has been for the past half century, the Kennedy Space Center will be the embarkation point for humankind's journey into the cosmos. Functioning as a next generation space launch complex, Kennedy's launch pads, integration facilities, processing areas, launch and recovery ranges will bustle with the activities of the world's space transportation providers. In developing this complex, KSC teams work through the potential operational scenarios: conducting trade studies, planning and budgeting for expensive and limited resources, and simulating alternative operational schemes. Numerous tools, among them discrete event simulation (DES), were matured during the Constellation Program to conduct such analyses with the purpose of optimizing the launch complex for maximum efficiency, safety, and flexibility while minimizing life cycle costs. Discrete event simulation is a computer-based modeling technique for complex and dynamic systems where the state of the system changes at discrete points in time and whose inputs may include random variables. DES is used to assess timelines and throughput, and to support operability studies and contingency analyses. It is applicable to any space launch campaign and informs decision-makers of the effects of varying numbers of expensive resources and the impact of off nominal scenarios on measures of performance. In order to develop representative DES models, methods were adopted, exploited, or created to extend traditional uses of DES. The Delphi method was adopted and utilized for task duration estimation. DES software was exploited for probabilistic event variation. A roll-up process was used, which was developed to reuse models and model elements in other less - detailed models. The DES team continues to innovate and expand

  17. From classical Lagrangians to Hamilton operators in the Standard-Model Extension

    CERN Document Server

    Schreck, Marco

    2016-01-01

    In this article we investigate whether a theory based on a classical Lagrangian for the minimal Standard-Model Extension (SME) can be quantized such that the result is equal to the corresponding low-energy Hamilton operator obtained from the field-theory description. This analysis is carried out for the whole collection of minimal Lagrangians found in the literature. The upshot is that first quantization can be performed consistently. The unexpected observation is made that at first order in Lorentz violation and at second order in the velocity the Lagrangians are related to the Hamilton functions by a simple transformation. Under mild assumptions, it is shown that this holds universally. This result is used successfully to obtain classical Lagrangians for two complicated sectors of the minimal SME that have not been considered in the literature so far. Therefore, it will not be an obstacle anymore to derive such Lagrangians even for involved sets of coefficients - at least to the level of approximation state...

  18. From classical Lagrangians to Hamilton operators in the standard model extension

    Science.gov (United States)

    Schreck, M.

    2016-07-01

    In this article we investigate whether a theory based on a classical Lagrangian for the minimal Standard Model Extension (SME) can be quantized such that the result is equal to the corresponding low-energy Hamilton operator obtained from the field-theory description. This analysis is carried out for the whole collection of minimal Lagrangians found in the literature. The upshot is that the first quantization can be performed consistently. The unexpected observation is made that at first order in Lorentz violation and at second order in the velocity, the Lagrangians are related to the Hamilton functions by a simple transformation. Under mild assumptions, it is shown that this holds universally. That result is used successfully to obtain classical Lagrangians for two complicated sectors of the minimal SME that have not been considered in the literature so far. Therefore, it will not be an obstacle anymore to derive such Lagrangians even for involved sets of coefficients—at least to the level of approximation stated above.

  19. A study of storage life extension for high performance chemically amplified resist coated blanks

    Science.gov (United States)

    Yang, Sin-Ju; Seo, Sung-Min; Ko, Sang-Hoon; Cha, Han-Sun; Kang, Geung-Won; Nam, Kee-Soo; Seo, Woong-Won; Jung, Woo-Kyun; Cho, Hyun-Kyoon; Kim, Jin-Min; Choi, Sang-Soo

    2005-06-01

    The importance of advanced e-beam writing system and chemically amplified resist (CAR) coated blank is increasing gradually in high-end grade photomask manufacture according to CD embodiment of 90 nm and beyond technology node requiring because of the shrinkage of design rule in the semiconductor industry. However, many studies have been reported that CAR has several troubles and especially, CAR sensitivity change is occurred by airborne molecular contamination (AMC). So, the storage life of CAR coated blank is shortened. This problem may cause the difficulty of high-end grade photomask manufacture because it is hard to secure stable mean to target (MTT) and CD uniformity by sensitivity change, T-top profile and footing profile. Therefore, the purpose of this paper is to investigate the storage life extension for high performance CAR coated blank through improvement of the packing materials. Firstly, a variety of packing materials were collected and the selected packing materials were analyzed by Automatic Thermal Desorption Gas Chromatograph/Mass Spectrometer (ATD GC/MS) and Ion Chromatograph (IC) to examine AMC generated from the packing materials. As a result, molecular condensables such as alcohols, hydrocarbons and fatty acids were detected and molecular acids and molecular bases those are NH4+, Cl-, NOx- and SOx- were also detected from the packing materials, respectively. From the above results, we selected the best packing materials which generated the least AMC and the worst packing materials which generated the most AMC. Additionally, we verified photomask process with CAR coated blanks which were packed with those packing materials with post coating delay (PCD) by 50 kV e-beam writing system. In consequence, dose to clear (DTC) showed 4.6 μC/cm2 at 0 day PCD for both of the best and the worst packing materials of CAR coated blank. After 90 days PCD, DTC variation was only 0.4 μC/cm2 for the best packing materials, but DTC variation of 4.0 μC/cm2

  20. 75 FR 8698 - Extension of Request for Scientific Views for Draft 2009 Update Aquatic Life Ambient Water...

    Science.gov (United States)

    2010-02-25

    ... of the request for scientific views. SUMMARY: On December 30, 2009 (74 FR 69086), EPA announced the... 1, 2010 (a 60-day request for scientific views). Since publication, the Agency has received several... AGENCY Extension of Request for Scientific Views for Draft 2009 Update Aquatic Life Ambient Water...

  1. Cybernetic principles of aging and rejuvenation: the buffering- challenging strategy for life extension.

    Science.gov (United States)

    Heylighen, Francis

    2014-01-01

    Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held in check by maximizing buffering capacity, range of compensatory actions, and knowledge about which action to apply to which disturbance. This suggests a general strategy for rejuvenating the organism by increasing its capabilities of adaptation. Buffering can be optimized by providing sufficient rest together with plenty of nutrients: amino acids, antioxidants, methyl donors, vitamins, minerals, etc. Knowledge and the range of action can be extended by subjecting the organism to an as large as possible variety of challenges. These challenges are ideally brief so as not to deplete resources and produce irreversible damage. However, they should be sufficiently intense and unpredictable to induce an overshoot in the mobilization of resources for damage repair, and to stimulate the organism to build stronger capabilities for tackling future challenges. This allows them to override the trade-offs and limitations that evolution has built into the organism's repair processes in order to conserve potentially scarce resources. Such acute, "hormetic" stressors strengthen the organism in part via the "order from noise" mechanism that destroys dysfunctional structures by subjecting them to strong, random variations. They include heat and cold, physical exertion, exposure, stretching, vibration, fasting, food toxins, micro-organisms, environmental enrichment and psychological challenges. The proposed buffering-challenging strategy may be able to extend life indefinitely, by forcing a periodic rebuilding and extension of capabilities, while using the Internet as an endless source of new knowledge about how to deal with disturbances.

  2. Life-cycle cost-benefit analysis of extensive vegetated roof systems.

    Science.gov (United States)

    Carter, Timothy; Keeler, Andrew

    2008-05-01

    The built environment has been a significant cause of environmental degradation in the previously undeveloped landscape. As public and private interest in restoring the environmental integrity of urban areas continues to increase, new construction practices are being developed that explicitly value beneficial environmental characteristics. The use of vegetation on a rooftop--commonly called a green roof--as an alternative to traditional roofing materials is an increasingly utilized example of such practices. The vegetation and growing media perform a number of functions that improve environmental performance, including: absorption of rainfall, reduction of roof temperatures, improvement in ambient air quality, and provision of urban habitat. A better accounting of the green roof's total costs and benefits to society and to the private sector will aid in the design of policy instruments and educational materials that affect individual decisions about green roof construction. This study uses data collected from an experimental green roof plot to develop a benefit cost analysis (BCA) for the life cycle of extensive (thin layer) green roof systems in an urban watershed. The results from this analysis are compared with a traditional roofing scenario. The net present value (NPV) of this type of green roof currently ranges from 10% to 14% more expensive than its conventional counterpart. A reduction of 20% in green roof construction cost would make the social NPV of the practice less than traditional roof NPV. Considering the positive social benefits and relatively novel nature of the practice, incentives encouraging the use of this practice in highly urbanized watersheds are strongly recommended.

  3. 77 FR 37839 - Veterans' Group Life Insurance (VGLI) No-Health Period Extension

    Science.gov (United States)

    2012-06-25

    ... removal of the words ``Servicemembers' Group Life Insurance or,'' which refers to Retired Reservist SGLI... 38 CFR Part 9 Life insurance, Military personnel, Veterans. Dated: June 20, 2012. Robert C....

  4. Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

    Directory of Open Access Journals (Sweden)

    Sager Jennifer

    2008-05-01

    Full Text Available Abstract Background Dietary restriction (DR increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood. Results Using bacterial food deprivation as a means of DR in C. elegans, we show that transient DR confers long-term benefits including stress resistance and increased longevity. Consistent with studies in the fruit fly and in mice, we demonstrate that DR also enhances survival when initiated late in life. DR by bacterial food deprivation significantly increases life span in worms when initiated as late as 24 days of adulthood, an age at which greater than 50% of the cohort have died. These survival benefits are, at least partially, independent of food consumption, as control fed animals are no longer consuming bacterial food at this advanced age. Animals separated from the bacterial lawn by a barrier of solid agar have a life span intermediate between control fed and food restricted animals. Thus, we find that life span extension from bacterial deprivation can be partially suppressed by a diffusible component of the bacterial food source, suggesting a calorie-independent mechanism for life span extension by dietary restriction. Conclusion Based on these findings, we propose that dietary restriction by bacterial deprivation increases longevity in C. elegans by a combination of reduced food consumption and decreased food sensing.

  5. MODEL 9975 LIFE EXTENSION TEST PACKAGE 3 - INTERIM REPORT - JANUARY 2017

    Energy Technology Data Exchange (ETDEWEB)

    Daugherty, W. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-01-31

    Life extension package LE3 (9975-03203) has been instrumented and subjected to an elevated temperature environment for approximately 8 years. During this time, the cane fiberboard has been maintained at a maximum temperature of ~160 - 165 °F, which was established by a combination of internal (19 watts) and external heat sources. Several tests and parameters were used to characterize the package components. Results from these tests generally indicate agreement between this full-scale shipping package and small-scale laboratory tests on fiberboard samples, including the degradation models based on the laboratory tests. These areas of agreement include the rate of change of fiberboard weight, dimensions and density, and change in fiberboard thermal conductivity. Corrosion of the lead shield occurred at a high rate during the first several weeks of aging, but dropped significantly after most of the moisture in the fiberboard migrated away from the lead shield. Dimensional measurements of the lead shield indicate that no significant creep deformation has occurred. This is consistent with literature data that predict a very small creep deformation for the time at temperature experienced by this package. The SCV O-rings were verified to remain leak-tight after ~5 years aging at an average temperature of ~170 °F. This package provides an example of the extent to which moisture within a typical fiberboard assembly can redistribute in the presence of a temperature gradient such as might be created by a 19 watt internal heat load. The majority of water within the fiberboard migrated to the bottom layers of fiberboard, with approximately 2 kg of water (2 liters) eventually escaping from the package. Two conditions have developed that are not consistent with package certification requirements. The axial gap at the top of the package increased to a maximum value of 1.549 inches, exceeding the 1 inch criterion. In addition, staining and/or corrosion have formed in a few spots

  6. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.

    Science.gov (United States)

    Khan, Maruf H; Ligon, Melissa; Hussey, Lauren R; Hufnal, Bryce; Farber, Robert; Munkácsy, Erin; Rodriguez, Amanda; Dillow, Andy; Kahlig, Erynn; Rea, Shane L

    2013-10-01

    While numerous life-extending manipulations have been discovered in the nematode Caenorhabditis elegans, one that remains most enigmatic is disruption of oxidative phosphorylation. In order to unravel how such an ostensibly deleterious manipulation can extend lifespan, we sought to identify the ensemble of nuclear transcription factors that are activated in response to defective mitochondrial electron transport chain (ETC) function. Using a feeding RNAi approach, we targeted over 400 transcription factors and identified 15 that, when reduced in function, reproducibly and differentially altered the development, stress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animals. Seven of these transcription factors--AHA-1, CEH-18, HIF-1, JUN-1, NHR-27, NHR-49 and the CREB homolog-1 (CRH-1)-interacting protein TAF-4--were also essential for isp-1 life extension. When we tested the involvement of these seven transcription factors in the life extension of two other Mit mutants, namely clk-1(qm30) and tpk-1(qm162), TAF-4 and HIF-1 were consistently required. Our findings suggest that the Mit phenotype is under the control of multiple transcriptional responses, and that TAF-4 and HIF-1 may be part of a general signaling axis that specifies Mit mutant life extension.

  7. A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties.

    Directory of Open Access Journals (Sweden)

    Felix Unverdorben

    Full Text Available Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD from streptococcal protein G (SpGC3 as module for half-life extension. SpGC3 is capable of binding to the Fc region as well as the CH1 domain of Fab arms under neutral and acidic conditions.Using site-directed mutagenesis, we generated a Fab-selective mutant (SpGC3Fab to avoid possible interference with the FcRn-mediated recycling process and improved its affinity for mouse and human IgG by site-directed mutagenesis and phage display selections. In mice, this affinity-improved mutant (SpGC3FabRR conferred prolonged plasma half-lives compared with SpGC3Fab when fused to small recombinant antibody fragments, such as single-chain Fv (scFv and bispecific single-chain diabody (scDb. Hence, the SpGC3FabRR domain seems to be a suitable fusion partner for the half-life extension of small recombinant therapeutics.The half-life extension properties of SpGC3 can be retained by restricting binding to the Fab fragment of serum immunoglobulins and can be improved by increasing binding activity. The modified SpGC3 module should be suitable to extend the half-life of therapeutic proteins and, thus to improve therapeutic activity.

  8. Can Quality of Work Life Affect Work Performance among Government Agriculture Extension Officers? A Case from Malaysia

    Directory of Open Access Journals (Sweden)

    O. Jamilah

    2010-01-01

    Full Text Available Problem statement: The importance of agriculture industry in enhancing the country economy cannot be denied. Recently, a total of USD 1.7 billion has been allocated by the government to boost this industry. Beside of this huge allocation, do the policy implementers which are the agriculture extension officers have adequate work performance to carry out the responsibility given to them? Approach: This study would like to discover whether quality of work life among the agriculture extension employee do have impact their work performance or not. It is necessary to estimate quality of work life function in enhancing work performance, analyze the most important factor and variables on this work performance. The instruments used for collecting data were: A scale on individual and family life, a scale on safety and security on the organization, a scale on interpersonal relationship in the organization, a scale on job satisfaction, a scale on organizational policies and management style, a scale on personnel health and well being, a scale on work environment, a scale on remuneration and a scale on organizational support. The data were analyzed PASW software. Results: Results depict that all of the nine qualities of work life studied have significant and positive relationship with work performance where the highest relationship occurred between individual and family life with work performance. Multiple regression analysis demonstrated that five factors which are individual and family life, job satisfaction, organization policy and management style, work environment and remuneration are the main contributors to work performance among government agricultural extension employees. Conclusion/Recommendations: From the results gained, it can be concluded that aspect of individual and family life is the highest contributor to work performance among government agriculture extension officer. It can be noted that more courses on how to manage individual and family

  9. 26 CFR 1.381(d)-1 - Operations loss carryovers of life insurance companies.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Operations loss carryovers of life insurance... loss carryovers of life insurance companies. For the application of part V, subchapter C, chapter 1 of the Code to operations loss carryovers of life insurance companies, see section 812(f) and §...

  10. On the assessment of biological life support system operation range

    Science.gov (United States)

    Bartsev, Sergey

    Biological life support systems (BLSS) can be used in long-term space missions only if well-thought-out assessment of the allowable operating range is obtained. The range has to account both permissible working parameters of BLSS and the critical level of perturbations of BLSS stationary state. Direct approach to outlining the range by statistical treatment of experimental data on BLSS destruction seems to be not applicable due to ethical, economical, and saving time reasons. Mathematical model is the unique tool for the generalization of experimental data and the extrapolation of the revealed regularities beyond empirical experience. The problem is that the quality of extrapolation depends on the adequacy of corresponding model verification, but good verification requires wide range of experimental data for fitting, which is not achievable for manned experimental BLSS. Possible way to improve the extrapolation quality of inevitably poorly verified models of manned BLSS is to extrapolate general tendency obtained from unmanned LSS theoretical-experiment investigations. Possibilities and limitations of such approach are discussed.

  11. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.

    Science.gov (United States)

    Park, Sang-Kyu; Link, Christopher D; Johnson, Thomas E

    2010-02-01

    Recent studies have shown that the rate of aging can be modulated by diverse interventions. Dietary restriction is the most widely used intervention to promote longevity; however, the mechanisms underlying the effect of dietary restriction remain elusive. In a previous study, we identified two novel genes, nlp-7 and cup-4, required for normal longevity in Caenorhabditis elegans. nlp-7 is one of a set of neuropeptide-like protein genes; cup-4 encodes an ion-channel involved in endocytosis by coelomocytes. Here, we assess whether nlp-7 and cup-4 mediate longevity increases by dietary restriction. RNAi of nlp-7 or cup-4 significantly reduces the life span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span of long-lived mutants resulting from reduced insulin/IGF-1 signaling or dysfunction of the mitochondrial electron transport chain. The life-span extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevented significantly in nlp-7 and cup-4 mutants. RNAi knockdown of genes encoding candidate receptors of NLP-7 and genes involved in endocytosis by coelomocytes also specifically shorten the life span of the eat-2 mutant. We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans.

  12. A study on the optimization of plant life extension and decommissioning for the improvement of economy in nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae In; Jung, K. J.; Chung, U. S.; Baik, S. T.; Park, S. K.; Lee, D. G.; Kim, H. R.; Park, B. Y

    2001-01-01

    Fundamental concepts on the life extension of the nuclear power plant and decommissioning optimization were established from the domestic abroad information and case analyses. Concerning the decommissioning of the nuclear power plant, the management according to decommissioning stages was analyzed by the investigation of the standard of the decommissioning(decontamination dismantling) regulation. Moreover, basics were set for the decommissioning of domestic nuclear power plants and research reactors from the analyses on the decommissioning technology and precedence.

  13. On Some Extensions of Szasz Operators Including Boas-Buck-Type Polynomials

    Directory of Open Access Journals (Sweden)

    Sezgin Sucu

    2012-01-01

    Full Text Available This paper is concerned with a new sequence of linear positive operators which generalize Szasz operators including Boas-Buck-type polynomials. We establish a convergence theorem for these operators and give the quantitative estimation of the approximation process by using a classical approach and the second modulus of continuity. Some explicit examples of our operators involving Laguerre polynomials, Charlier polynomials, and Gould-Hopper polynomials are given. Moreover, a Voronovskaya-type result is obtained for the operators containing Gould-Hopper polynomials.

  14. A life cycle cost economics model for projects with uniformly varying operating costs. [management planning

    Science.gov (United States)

    Remer, D. S.

    1977-01-01

    A mathematical model is developed for calculating the life cycle costs for a project where the operating costs increase or decrease in a linear manner with time. The life cycle cost is shown to be a function of the investment costs, initial operating costs, operating cost gradient, project life time, interest rate for capital and salvage value. The results show that the life cycle cost for a project can be grossly underestimated (or overestimated) if the operating costs increase (or decrease) uniformly over time rather than being constant as is often assumed in project economic evaluations. The following range of variables is examined: (1) project life from 2 to 30 years; (2) interest rate from 0 to 15 percent per year; and (3) operating cost gradient from 5 to 90 percent of the initial operating costs. A numerical example plus tables and graphs is given to help calculate project life cycle costs over a wide range of variables.

  15. A life cycle cost economics model for projects with uniformly varying operating costs. [management planning

    Science.gov (United States)

    Remer, D. S.

    1977-01-01

    A mathematical model is developed for calculating the life cycle costs for a project where the operating costs increase or decrease in a linear manner with time. The life cycle cost is shown to be a function of the investment costs, initial operating costs, operating cost gradient, project life time, interest rate for capital and salvage value. The results show that the life cycle cost for a project can be grossly underestimated (or overestimated) if the operating costs increase (or decrease) uniformly over time rather than being constant as is often assumed in project economic evaluations. The following range of variables is examined: (1) project life from 2 to 30 years; (2) interest rate from 0 to 15 percent per year; and (3) operating cost gradient from 5 to 90 percent of the initial operating costs. A numerical example plus tables and graphs is given to help calculate project life cycle costs over a wide range of variables.

  16. Parametric Extension of the Most Preferred OWA Operator and Its Application in Search Engine's Rank

    Directory of Open Access Journals (Sweden)

    Xiuzhi Sang

    2013-01-01

    Full Text Available Most preferred ordered weighted average (MP-OWA operator is a new kind of neat (dynamic weight OWA operator in the aggregation operator families. It considers the preferences of all alternatives across the criteria and provides unique aggregation characteristics in decision making. In this paper, we propose the parametric form of the MP-OWA operator to deal with the uncertainty preference information, which includes MP-OWA operator as its special case, and it also includes the most commonly used maximum, minimum, and average aggregation operators. A special form of parametric MP-OWA operator with power function is proposed. Some properties of the parametric MP-OWA operator are provided and the advantages of them in decision making problems are summarized. The new proposed parametric MP-OWA operator can grasp the subtle preference information of the decision maker according to the application context through multiple aggregation results. They are applied to rank search engines considering the relevance of the retrieved queries. An search engine ranking example illustrates the application of parametric MP-OWA operator in various decision situations.

  17. 77 FR 66069 - Veterans' Group Life Insurance (VGLI) No-Health Period Extension

    Science.gov (United States)

    2012-11-01

    ...,'' which refer to Retired Reservist SGLI, which was discontinued by Public Law 104-275 as an independent..., 2012, for publication. List of Subjects in 38 CFR Part 9 Life insurance, Military personnel,...

  18. An Analysis of the U.S. Navy P-3C Orion Service Life Extension Program

    Science.gov (United States)

    2013-09-01

    service life assessment program ( SLAP ) to determine not only the severity of the corrosion problem, but also the structural life remaining on the...airframe. In addition, SLAP offered corrective structural remedies if the aircraft were suitable for SLEP. SLAP results were promising: The airframe...a third of its fleet on the ramp. This thesis analyzes the challenges of SLEP. 14. SUBJECT TERMS P-3C Orion, SLEP, SLAP , SRP 15

  19. 75 FR 54366 - BOEMRE Information Collection Activity: 1010-0086, Sulphur Operations, Extension of a Collection...

    Science.gov (United States)

    2010-09-07

    ... 30, 2010, we published a Federal Register notice (75 FR 15718) announcing that we would submit this... Bureau of Ocean Management, Regulation and Enforcement BOEMRE Information Collection Activity: 1010-0086.... ACTION: Notice of extension of an information collection (1010-0086). SUMMARY: To comply with...

  20. Three lectures on global boundary conditions and the theory of self--adjoint extensions of the covariant Laplace--Beltrami and Dirac operators on Riemannian manifolds with boundary

    CERN Document Server

    Ibort, A

    2012-01-01

    In these three lectures we will discuss some fundamental aspects of the theory of self-adjoint extensions of the covariant Laplace-Beltrami and Dirac operators on compact Riemannian manifolds with smooth boundary emphasizing the relation with the theory of global boundary conditions. Self-adjoint extensions of symmetric operators, specially of the Laplace-Beltrami and Dirac operators, are fundamental in Quantum Physics as they determine either the energy of quantum systems and/or their unitary evolution. The well-known von Neumann's theory of self-adjoint extensions of symmetric operators is not always easily applicable to differential operators, while the description of extensions in terms of boundary conditions constitutes a more natural approach. Thus an effort is done in offering a description of self-adjoint extensions in terms of global boundary conditions showing how an important family of self-adjoint extensions for the Laplace-Beltrami and Dirac operators are easily describable in this way. Moreover ...

  1. Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

    Science.gov (United States)

    Hans, Harvir; Lone, Asad; Aksenov, Vadim; Rollo, C David

    2015-01-01

    We examined the impacts of aspirin and metformin on the life history of the cricket Acheta domesticus (growth rate, maturation time, mature body size, survivorship, and maximal longevity). Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls). Increases in general survivorship were even more pronounced, with low-dose aspirin yielding mean longevity 234 % of controls (i.e., health span). Metformin strongly reduced growth rates of both genders (140 % of controls) than aspirin (~118 % of controls). Crickets maturing on low aspirin showed no evidence of a trade-off between maturation mass and life extension. Remarkably, by 100 days of age, aspirin-treated females were significantly larger than controls (largely reflecting egg complement). Unlike the reigning dietary restriction paradigm, low aspirin conformed to a paradigm of "eat more, live longer." In contrast, metformin-treated females were only ~67 % of the mass of controls. Our results suggest that hormetic agents like metformin may derive significant trade-offs with life extension, whereas health and longevity benefits may be obtained with less cost by agents like aspirin that regulate geroprotective pathways.

  2. Meat shelf-life and extension using collagen/gelatin coatings: a review.

    Science.gov (United States)

    Antoniewski, M N; Barringer, S A

    2010-08-01

    Different factors lead to the end of shelf-life for fresh meat products. The factors depend upon the animal including breed difference and muscle fiber type, external influences such as diet and stress, and post-harvest storage conditions including time, temperature, and packaging atmosphere. The characteristics that indicate the end of shelf-life for fresh meat products include water loss/purge accumulation, color deterioration due to myoglobin oxidation, rancidity due to lipid oxidation, and microbial spoilage. The characteristics can be measured and studied in the laboratory. Meat shelf-life is extended with the application of a surface coating because it provides a water and oxygen barrier. Collagen and gelatin coatings are used as a barrier on meat products to reduce purge, color deterioration, aroma deterioration, and spoilage, improve sensory scores, and act as an antioxidant.

  3. Extension of shelf life of whole and peeled shrimp with organic acid salts and bifidobacteria.

    Science.gov (United States)

    Al-Dagal, M M; Bazaraa, W A

    1999-01-01

    Microbiological and sensory characteristics of treated whole and peeled shrimp from the east coast of Saudi Arabia were evaluated. Shrimp samples were treated with organic acid salts with or without Bifidobacterium breve culture and stored in ice. Peeling alone extended the microbiological shelf life by 4 days. Treatment of whole shrimp with sodium acetate alone or potassium sorbate with bifidobacteria prolonged the microbiological shelf life by 3 days and increased the microbial generation time from 12.8 h (control) to 30.1 h or 31.4 h, respectively. The microbiological and sensory shelf life of peeled shrimp treated with sodium acetate was more than 17 days. Sodium acetate extended the microbial lag phase and lengthened the generation time (38.7 h compared to 15.8 h for the control). Micrococci and coryneforms were the predominant microorganisms in whole shrimp during storage. Treatment with sodium acetate maintained better sensory characteristics for peeled shrimp than potassium sorbate combined with bifidobacteria.

  4. SET-VALUED EXTENSION OF OPERATORS VIA STEINER SELECTIONS(Ⅱ)-APPLICATIONS TO APPROXIMATION

    Institute of Scientific and Technical Information of China (English)

    Ter(a)n,Pedro; L(o)pez-D(I)az,Miguel

    2002-01-01

    On the basis of Part (Ⅰ) of this series some applications to the approximation ofset-valued functions are obtained: Korovkin type theorems, a method to extend classicalapproximation operators to the set-valued setting and a Jackson type estimate.

  5. VITASCOPE: Extensible and Scalable 3D Visualization of Simulated Construction Operations

    OpenAIRE

    Kamat, Vineet Rajendra

    2003-01-01

    In the domain of operations design and analysis, the ability to see a 3D animation of processes that have been simulated allows for three very important things: 1) The developer of a simulation model can ascertain that there are no errors in the coding (Verification); 2) The experts, field personnel, and decision makers can discover differences between the way they understand the operation and the way the model developer understands it (Validation); and 3) A model can be communicated effectiv...

  6. Spoilage and shelf-life extension of fresh fish and shellfish.

    Science.gov (United States)

    Ashie, I N; Smith, J P; Simpson, B K

    1996-01-01

    Fresh fish and shellfish are highly perishable products due to their biological composition. Under normal refrigerated storage conditions, the shelf life of these products is limited by enzymatic and microbiological spoilage. However, with increasing consumer demands for fresh products with extended shelf life and increasing energy costs associated with freezing and frozen storage, the fish-processing industry is actively seeking alternative methods of shelf life preservation and marketability of fresh, refrigerated fish and at the same time economizing on energy costs. Additional methods that could fulfill these objectives include chemical decontamination, low-dose irradiation, ultra-high pressure, and modified atmosphere packaging (MAP). This review focuses on the biochemical and microbiological composition of fresh fish/shellfish, the spoilage patterns in these products, factors influencing spoilage, and the combination treatments that can be used in conjunction with refrigeration to extend the shelf life and keeping quality of fresh fish/shellfish. The safety concerns of minimally processed/MAP fish, specifically with respect to the growth of Clostridium botulinum type E, is also addressed.

  7. Clinical and operational value of the extensively drug-resistant tuberculosis definition.

    Science.gov (United States)

    Migliori, G B; Besozzi, G; Girardi, E; Kliiman, K; Lange, C; Toungoussova, O S; Ferrara, G; Cirillo, D M; Gori, A; Matteelli, A; Spanevello, A; Codecasa, L R; Raviglione, M C

    2007-10-01

    Currently, no information is available on the effect of resistance/susceptibility to first-line drugs different from isoniazid and rifampicin in determining the outcome of extensively drug-resistant tuberculosis (XDR-TB) patients, and whether being XDR-TB is a more accurate indicator of poor clinical outcome than being resistant to all first-line anti-tuberculosis (TB) drugs. To investigate this issue, a large series of multidrug-resistant TB (MDR-TB) and XDR-TB cases diagnosed in Estonia, Germany, Italy and the Russian Federation during the period 1999-2006 were analysed. Drug-susceptibility testing for first- and second-line anti-TB drugs, quality assurance and treatment delivery was performed according to World Health Organization recommendations in all study sites. Out of 4,583 culture-positive TB cases analysed, 361 (7.9%) were MDR and 64 (1.4%) were XDR. XDR-TB cases had a relative risk (RR) of 1.58 to have an unfavourable outcome compared with MDR-TB cases resistant to all first-line drugs (isoniazid, rifampicin ethambutol, streptomycin and, when tested, pyrazinamide), and an RR of 2.61 compared with "other" MDR-TB cases (those susceptible to at least one first-line anti-TB drug among ethambutol, pyrazinamide and streptomycin, regardless of resistance to the second-line drugs not defining XDR-TB). The emergence of extensively drug-resistant tuberculosis confirms that problems in tuberculosis management are still present in Europe. While waiting for new tools which will facilitate management of extensively drug-resistant tuberculosis, accessibility to quality diagnostic and treatment services should be urgently ensured and adequate public health policies should be rapidly implemented to prevent further development of drug resistance.

  8. Stabilizing control system preventing loss of synchronism from extension and its actual operating experience

    Energy Technology Data Exchange (ETDEWEB)

    Matsuzawa, K.; Yanagihashi, K.; Tsukita, J. [Tokyo Electric Power Co. (Japan); Sato, M.; Nakamura, T.; Takeuchi, A.

    1995-08-01

    This paper presents a stabilizing control system that was implemented to the power system of Tokyo Electric Power Company and worked successfully, shedding the minimum number of generators and preventing the extension of loss of synchronism to the other generators when a severe fault occurred on May 22, 1992. The stabilizing control system measures voltage and current at the rate of 600 Hz, predicts the change of phase angles of generators and decides the minimum number of generators to be shed for stabilization when instability is predicted and sheds them.

  9. The Whyalla No. 2 blast furnace life extension with improved productivity and quality

    Energy Technology Data Exchange (ETDEWEB)

    Ward, R.F.; Broadbent, P.F.; Tsalapatis, J.

    1993-01-01

    The performance of the Whyalla No. 2 Blast Furnace has previously been reported, and at the time of that report it was planned that the furnace would be relined in January 1993. The actions and improvements previously reported have proved to be more beneficial than it was initially thought possible, and have since been progressed to the stage where a campaign life in excess of 15 years is now realistically targeted. This paper highlights the actions that have proved successful in exceeding 12 years of campaign life and current average productivity of 2.1 t/m[sup 3]/d I.V., fuel rate of less than 500 kg/thm and Hot Metal Silicon standard deviation less than 0.1%.

  10. High-cycle Fatigue Life Extension of Glass Fiber/Polymer Composites with Carbon Nanotubes

    Institute of Scientific and Technical Information of China (English)

    Christopher S Grimmer; C K H Dharan

    2009-01-01

    The present work shows that the addition of small volume fractions of multi-walled carbon nanotubes (CNTs) to the matrix results in a significant increase in the high-cycle fatigue life. It is proposed that carbon nanotubes tend to inhibit the formation of large cracks by nucleating nano-scale damage zones. In addition, the contribution to energy absorption from the fracture of nanotubes bridging across nano-scale cracks and from nanotube pull-out from the matrix are mechanisms that can improve the fatigue life. An energy-based model was proposed to estimate the additional strain energy absorbed in fatigue. The distributed nanotubes in the matrix appear to both distribute damage as well as inhibit damage propagation resulting in an overall improvement in the fatigue strength of glass fiber composites.

  11. Shelf life extension of fresh turmeric ( Curcuma longa L.) using gamma radiation

    Science.gov (United States)

    Dhanya, R.; Mishra, B. B.; Khaleel, K. M.; Cheruth, Abdul Jaleel

    2009-09-01

    Gamma radiation processing was found to extend shelf life of fresh turmeric. A 5 kGy radiation dose and 10 °C storage temperature was found to keep peeled turmeric samples microbe free and acceptable until 60 days of storage. The control sample without radiation treatment spoiled within a week of storage. The changes in color, texture and moisture content of fresh turmeric due to radiation treatment were found to be statistically insignificant.

  12. Shelf life extension of fresh turmeric (Curcuma longa L.) using gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Dhanya, R. [P.G. Department and Research Centre in Botany, Sir Syed College, Taliparamba 670142, Kerala (India); Mishra, B.B. [Food Technology Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Khaleel, K.M. [P.G. Department and Research Centre in Botany, Sir Syed College, Taliparamba 670142, Kerala (India)], E-mail: khaleelchovva@yahoo.co.in; Cheruth, Abdul Jaleel [DMJM International (Cansult Maunsell/AECOM Ltd.), Consultant of Gardens Sector Projects, Alain Municipality and Eastern Emirates, P.O. Box 1419, Al-Ain, Abu Dhabi (United Arab Emirates)], E-mail: abdul79jaleel@yahoo.co.in

    2009-09-15

    Gamma radiation processing was found to extend shelf life of fresh turmeric. A 5 kGy radiation dose and 10 {sup o}C storage temperature was found to keep peeled turmeric samples microbe free and acceptable until 60 days of storage. The control sample without radiation treatment spoiled within a week of storage. The changes in color, texture and moisture content of fresh turmeric due to radiation treatment were found to be statistically insignificant.

  13. Reactor Dosimetry Aspects of the Service Life Extension of the Hungarian Paks NPP

    Directory of Open Access Journals (Sweden)

    Zsolnay Eva M.

    2016-01-01

    Full Text Available The service life of the Hungarian Paks Nuclear Power Plant (NPP will be extended from the originally planned 30 years to 50 years. To improve the reliability of the results obtained in frame of the old reactor pressure vessel (RPV surveillance programme, new methods have been developed, and based on them, the old exposition data have been re-evaluated for all the four reactor units. At the same time, a new RPV surveillance programme has been developed and introduced, and long term irradiations have been performed to determine the radiation damage of the surveillance specimens due to the high fast neutron exposition. Neutron transport calculations have been performed with a validated neutron transport code system to determine the fast neutron exposition of the RPVs during the extended service life. The cavity dosimetry is in the introductory phase. This paper presents the new developments in the field of the RPV surveillance dosimetry and summarises the results obtained. According to the results the service life of the NPP can safely be extended for the planned 50 years.

  14. Use of E-Beam for Shelf-Life Extension and Sanitizing of Marinated Pork Loin

    Science.gov (United States)

    García-Márquez, I.; Ordóñez, J. A.; Cambero, M. I.; Cabeza, M. C.

    2012-01-01

    The effectiveness of E-beam radiation to extend the shelf-life of marinated pork loin slices stored at 4 and 8°C (temperature abuse) has been studied. The shelf-life was extended from 7 to 16 and >20 days after the application of 1 and 2 kGy, respectively. In the event of a temperature abuse occuring during the product distribution (e.g., increase to 8°C), the shelf-life would be extended from 5 to 10 and 16 days, respectively, when applying the doses mentioned previously. From a public health point of view, the irradiation of marinated pork loin may be marketable for a longer period of time of up to two weeks, and guarantees a practically Salmonella and Listeria-free product. Minor changes are produced by the E-beam treatment in the main sensory and rheological characteristics. The odor was the most affected feature, but the off-odors diminished with increased storage. In any case, testers judged the samples to be adequate for marketing. PMID:23227053

  15. Shelf-life extension and sanitation of fresh pork loin by E-beam treatment.

    Science.gov (United States)

    García-Márquez, Irene; Cambero, María I; Ordóñez, Juan A; Cabeza, María C

    2012-12-01

    The usefulness of electron beam (E-beam) irradiation to increase the shelf life of whole fresh pork loin stored at 4°C has been studied. The shelf life was extended from 5 to 11 and 20 days after the application of 1 and 2 kGy, respectively. If a temperature abuse situation were to occur during product distribution (e.g., increase to 8°C), the shelf life would be extended from 3 to 8 and 15 days, respectively, after application of the same doses. When considering Listeria monocytogenes from a public health point of view, the irradiated whole fresh loin may be marketable for periods longer than 2 weeks, thus guaranteeing a practically Listeria-free product. Irradiation produced no important changes in the rheological characteristics of the meat. Although the sensory quality of irradiated meat was scored lower than the control immediately after irradiation, after 5 days in storage, irradiated meat scored higher than or not different from the control.

  16. Use of E-Beam for Shelf-Life Extension and Sanitizing of Marinated Pork Loin

    Directory of Open Access Journals (Sweden)

    I. García-Márquez

    2012-01-01

    Full Text Available The effectiveness of E-beam radiation to extend the shelf-life of marinated pork loin slices stored at 4 and 8°C (temperature abuse has been studied. The shelf-life was extended from 7 to 16 and >20 days after the application of 1 and 2 kGy, respectively. In the event of a temperature abuse occuring during the product distribution (e.g., increase to 8°C, the shelf-life would be extended from 5 to 10 and 16 days, respectively, when applying the doses mentioned previously. From a public health point of view, the irradiation of marinated pork loin may be marketable for a longer period of time of up to two weeks, and guarantees a practically Salmonella and Listeria-free product. Minor changes are produced by the E-beam treatment in the main sensory and rheological characteristics. The odor was the most affected feature, but the off-odors diminished with increased storage. In any case, testers judged the samples to be adequate for marketing.

  17. LIFE Cost of Electricity, Capital and Operating Costs

    Energy Technology Data Exchange (ETDEWEB)

    Anklam, T

    2011-04-14

    Successful commercialization of fusion energy requires economic viability as well as technical and scientific feasibility. To assess economic viability, we have conducted a pre-conceptual level evaluation of LIFE economics. Unit costs are estimated from a combination of bottom-up costs estimates, working with representative vendors, and scaled results from previous studies of fission and fusion plants. An integrated process model of a LIFE power plant was developed to integrate and optimize unit costs and calculate top level metrics such as cost of electricity and power plant capital cost. The scope of this activity was the entire power plant site. Separately, a development program to deliver the required specialized equipment has been assembled. Results show that LIFE power plant cost of electricity and plant capital cost compare favorably to estimates for new-build LWR's, coal and gas - particularly if indicative costs of carbon capture and sequestration are accounted for.

  18. Krein-like extensions and the lower boundedness problem for elliptic operators on exterior domains

    DEFF Research Database (Denmark)

    Grubb, Gerd

    2012-01-01

    Artiklen behandler to problemer for realisationer af elliptiske differentialoperatorer, ved funktionalanalytiske og pseudodifferentielle metoder. Det ene er spørgsmålet om ækvivalens af nedad begrænsethed af realisationen og en dertil hørende operator på randen, som besvares bekræftende for ydre ...

  19. An extensive catalog of operators for the coupled evolution of metamodels and models

    NARCIS (Netherlands)

    Herrmannnsdoerfer, M.; Vermolen, S.D.; Wachsmuth, G.

    2010-01-01

    Modeling languages and thus their metamodels are subject to change. When a metamodel is evolved, existing models may no longer conform to it. Manual migration of these models in response to metamodel evolution is tedious and error-prone. To significantly automate model migration, operator-based

  20. An Examination of Operational Availability in Life Cycle Cost Models

    Science.gov (United States)

    1983-09-01

    Systems. Kenneth E. Marks, H. Garrison Massey, and Brent D. Bradley. Rand No. R-2287-AF. Santa Monica CA: The Rand Corporation, October 1978. AD...AFB OH, September 1982. AD A123045. Bryan, Noreen S.; Jacqueline J. Rosen; and Nancey T. Marland. "A New Life Cycle Cost Model: Flexible, Interactive

  1. Expert Panel Recommendations for Hanford Double-Shell Tank Life Extension

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Charles W; Bush, Spencer H; Berman, Herbert Stanton; Czajkowski, Carl J; Divine, James R; Posakony, Gerald J; Johnson, A B; Elmore, Monte R; Reynolds, D A; Anantatmula, Ramamohan P; Sindelar, Robert L; Zapp, Philip E

    2001-06-29

    Expert workshops were held in Richland in May 2001 to review the Hanford Double-Shell Tank Integrity Project and make recommendations to extend the life of Hanford's double-shell waste tanks. The workshop scope was limited to corrosion of the primary tank liner, and the main areas for review were waste chemistry control, tank inspection, and corrosion monitoring. Participants were corrosion experts from Hanford, Savannah River Site, Brookhaven National Lab., Pacific Northwest National Lab., and several consultants. This report describes the current state of the three areas of the program, the final recommendations of the workshop, and the rationale for their selection.

  2. Veterans' Group Life Insurance (VGLI) no-health period extension. Final rule.

    Science.gov (United States)

    2012-11-01

    The Department of Veterans Affairs (VA) is issuing this final rule that amends the regulations governing eligibility for Veterans' Group Life Insurance (VGLI) to extend to 240 days the current 120-day "no-health" period during which veterans can apply for VGLI without proving that they are in good health for insurance purposes. The purpose of this rule is to increase the opportunities for disabled veterans to enroll in VGLI, some of whom would not qualify for VGLI coverage under existing provisions. This document adopts as a final rule, without change, the proposed rule published in the Federal Register on June 25, 2012.

  3. LCC-OPS: Life Cycle Cost Application in Aircraft Operations

    NARCIS (Netherlands)

    Suwondo, E.

    2007-01-01

    Observation of current practices in aircraft operations and maintenance shows limited consideration of cost savings applied by aircraft modifications, maintenance program optimisation and aircraft selection. This is due to hidden (maintenance dependent) costs and difficulties in quantifying the

  4. Stable, inflatable life raft for high seas rescue operations

    Science.gov (United States)

    Barnett, J. H., Jr.; Harrison, F.; Marak, R.; Radnofsky, M. I.

    1971-01-01

    Raft is easily deployed and highly maneuverable in water. It has false bottom of water ballast containers attached to underside, making it exceptionally stable platform from which swimmers can operate. Raft is attachable to external moorings.

  5. LCC-OPS: Life Cycle Cost Application in Aircraft Operations

    NARCIS (Netherlands)

    Suwondo, E.

    2007-01-01

    Observation of current practices in aircraft operations and maintenance shows limited consideration of cost savings applied by aircraft modifications, maintenance program optimisation and aircraft selection. This is due to hidden (maintenance dependent) costs and difficulties in quantifying the util

  6. Shelf-life extension of Pacific white shrimp using algae extracts during refrigerated storage.

    Science.gov (United States)

    Li, Yingchang; Yang, Zhongyan; Li, Jianrong

    2017-01-01

    Shrimp is a low-fat, high-protein aquatic product, and is susceptible to spoilage during storage. To establish an effective method for the quality control of Pacific white shrimp, the effects of polyphenols (PP) and polysaccharides (PS) from Porphyra yezoensis on the quality of Pacific white shrimp were assessed during refrigerated storage. Pacific white shrimp samples were treated with 5 g L(-1) polyphenols, and 8 g L(-1) polysaccharides, then stored at 4 ± 1 °C for 8 days. All samples were subjected to measurement of total viable count (TVC), pH, total volatile basic nitrogen (TVB-N), K-value, thiobarbituric acid (TBA), polyphenol oxidase (PPO) activity, and were also assessed by sensory evaluation. The results showed that PP, PS, and the mixture of polyphenols and polysaccharides (PP+PS) could inhibit the increase of total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA) and K-value, and reduce total viable count (TVC) compared with the control group. PP could also inhibit polyphenol oxidase (PPO) activity. Sensory evaluation proved the efficacy of PP and PS by maintaining the overall quality of Pacific white shrimp during refrigerated storage. Moreover, PP+PS could extend the shelf-life of shrimp by 3-4 days compared with the control group. PP+PS could more effectively maintain quality and extend shelf-life during refrigerated storage. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  7. Effect of nisin on shelf-life extension of filleted rainbow trout (Oncorhynchus mykiss

    Directory of Open Access Journals (Sweden)

    Shabnam Behnama

    2016-08-01

    Full Text Available The objective of this study was to investigate influence of nisin on quality and shelf-life of filleted rainbow trout (Oncorhynchus mykiss during 16 days storage at 4oC by biochemical and microbial assessments. The obtained results revealed that nisin treated samples showed lower (P<0.05 biochemical (peroxide value, thiobarbituric acid-index, pH, free fatty acids, and total volatile base nitrogen and bacteriological (total viable counts and lactic acid bacteria attributes during whole storage time compared with the untreated fillets, which can be related to bactericidal and antioxidant activity of the nisin. However, total volatile base nitrogen and total viable count values exceeded above the acceptability on day 8 and 12 of storage for the samples treated without and with nisin, respectively. The results of this study according to biochemical and bacteriological data indicated that nisin enhanced the quality and shelf-life of filleted rainbow trout from 4 to 8 days during storage at 4oC.

  8. Extension of the shelf life of guava by individual packaging with cling and shrink films.

    Science.gov (United States)

    Rana, Seema; Siddiqui, Saleem; Goyal, Ankit

    2015-12-01

    Guava is a climacteric fruit so physico-chemical changes continuously occur after harvest till fruit become unfit for consumption and suffers from post harvest losses. The main objective of this work was to assess the effectiveness of individual film in form of Shrink and Cling wrap on shelf life of guava. Fruits were individually packed in polythene bags (LDPE) of 200 gauge thickness by Shrink and Cling wrapping and stored at 7 ± 3 °C. Individual wrapping reduced the magnitude of changes during storage i.e., ripening process drastically as evident from lower total soluble solids, higher ascorbic acid, polyphenol content with lower polyphenol oxidase activity and physiological loss of weight (PLW) was less than 3.5 %. Film wrapping preserved freshness of wrapped fruits as they remained acceptable for whole storage time in contrast to control fruits which turned unacceptable by 15(th) day of storage. Control fruits showed significant compositional changes as well as in polyphenol content, ascorbic acid and reduced number of marketable fruits while Cling and Shrink wrapping enhanced the shelf life by 10 days.

  9. Shelf life extension of fresh fruit and vegetables by chitosan treatment.

    Science.gov (United States)

    Romanazzi, Gianfranco; Feliziani, Erica; Baños, Silvia Bautista; Sivakumar, Dharini

    2017-02-11

    Among alternatives that are currently under investigation to replace the use of synthetic fungicides to control postharvest diseases in fresh produce and to extend their shelf life, chitosan application has shown promising disease control, at both preharvest and postharvest stages. Chitosan shows a dual mode of action, on the pathogen and on the plant, as it reduces the growth of decay-causing fungi and foodborne pathogens and induces resistance responses in the host tissues. Chitosan coating forms a semipermeable film on the surface of fruit and vegetables, thereby delaying the rate of respiration, decreasing weight loss, maintaining the overall quality, and prolonging the shelf life. Moreover, the coating can provide a substrate for incorporation of other functional food additives, such as minerals, vitamins, or other drugs or nutraceutical compounds that can be used to enhance the beneficial properties of fresh commodities, or in some cases the antimicrobial activity of chitosan. Chitosan coating has been approved as GRAS substance by USFDA, and its application is safe for the consumer and the environment. This review summarizes the most relevant and recent knowledge in the application of chitosan in postharvest disease control and maintenance of overall fruit and vegetable quality during postharvest storage.

  10. Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.

    Science.gov (United States)

    Lu, Shu-Ping; Kato, Michiko; Lin, Su-Ju

    2009-06-19

    NAD(+) (nicotinamide adenine dinucleotide) is an essential cofactor involved in various biological processes including calorie restriction-mediated life span extension. Administration of nicotinamide riboside (NmR) has been shown to ameliorate deficiencies related to aberrant NAD(+) metabolism in both yeast and mammalian cells. However, the biological role of endogenous NmR remains unclear. Here we demonstrate that salvaging endogenous NmR is an integral part of NAD(+) metabolism. A balanced NmR salvage cycle is essential for calorie restriction-induced life span extension and stress resistance in yeast. Our results also suggest that partitioning of the pyridine nucleotide flux between the classical salvage cycle and the NmR salvage branch might be modulated by the NAD(+)-dependent Sir2 deacetylase. Furthermore, two novel deamidation steps leading to nicotinic acid mononucleotide and nicotinic acid riboside production are also uncovered that further underscore the complexity and flexibility of NAD(+) metabolism. In addition, utilization of extracellular nicotinamide mononucleotide requires prior conversion to NmR mediated by a periplasmic phosphatase Pho5. Conversion to NmR may thus represent a strategy for the transport and assimilation of large nonpermeable NAD(+) precursors. Together, our studies provide a molecular basis for how NAD(+) homeostasis factors confer metabolic flexibility.

  11. Fantastic voyage: live long enough to live forever. The science behind radical life extension questions and answers.

    Science.gov (United States)

    Kurzweil, Ray; Grossman, Terry

    2009-01-01

    Putting an end to human aging is now becoming a reality, and immortality is no longer just a dream. Through what we are calling "Fantastic Voyage," we provide a guide to achieving life extension through various means, thereby slowing down aging and disease processes. The three components of Fantastic Voyage are: Bridge One--Aggressively applying today's knowledge. Bridge Two--Putting biotechnology, such as gene technologies, to use with therapeutic cloning and rejuvenation medicine. Bridge Three--Putting nanotechnology to use by developing a means to rebuild our bodies and brains with nanobots. Many of these technology solutions can be simulated today through the use of targeted supplements, designed to address the specific needs of an individual, such as insulin resistance, cholesterol and homocysteine levels, and inflammation. To slow aging now, we propose a program of supplementing aggressively, eating foods that impede aging and disease processes, and reversing inflammation through diet. We also provide guidance to customize each program to the specific needs of the individual. Emerging technologies in rational drug design, tissue engineering, gene therapy, and nanobots (among others) promise a future of automated life extension. The use of such technologies, and the resulting dramatic increases in productivity in all areas of human endeavor, will enable us to live in a world in which all our physical needs can be met.

  12. Water-based oligochitosan and nanowhisker chitosan as potential food preservatives for shelf-life extension of minced pork.

    Science.gov (United States)

    Chantarasataporn, Patomporn; Tepkasikul, Preenapha; Kingcha, Yutthana; Yoksan, Rangrong; Pichyangkura, Rath; Visessanguan, Wonnop; Chirachanchai, Suwabun

    2014-09-15

    Water-based chitosans in the forms of oligochitosan (OligoCS) and nanowhisker chitosan (CSWK) are proposed as a novel food preservative based on a minced pork model study. The high surface area with a positive charge over the neutral pH range (pH 5-8) of OligoCS and CSWK lead to an inhibition against Gram-positive (Staphylococcus aureus, Listeria monocytogenes, and Bacillus cereus) and Gram-negative microbes (Salmonella enteritidis and Escherichia coli O157:H7). In the minced pork model, OligoCS effectively performs a food preservative for shelf-life extension as clarified from the retardation of microbial growth, biogenic amine formation and lipid oxidation during the storage. OligoCS maintains almost all myosin heavy chain protein degradation as observed in the electrophoresis. The present work points out that water-based chitosan with its unique morphology not only significantly inhibits antimicrobial activity but also maintains the meat quality with an extension of shelf-life, and thus has the potential to be used as a food preservative.

  13. Feedback-assisted extension of the tokamak operating space to low safety factor

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, J. M., E-mail: jmh2130@columbia.edu; Bialek, J. M.; Navratil, G. A.; Olofsson, K. E. J.; Shiraki, D.; Turco, F. [Department of Applied Mathematics and Applied Physics, Columbia University, New York, New York 10027-6900 (United States); Baruzzo, M.; Bolzonella, T.; Marrelli, L.; Martin, P.; Piovesan, P.; Piron, C.; Piron, L.; Terranova, D.; Zanca, P. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Hyatt, A. W.; Jackson, G. L.; La Haye, R. J.; Lanctot, M. J.; Strait, E. J. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); and others

    2014-07-15

    Recent DIII-D and RFX-mod experiments have demonstrated stable tokamak operation at very low values of the edge safety factor q(a) near and below 2. The onset of n = 1 resistive wall mode (RWM) kink instabilities leads to a disruptive stability limit, encountered at q(a) = 2 (limiter plasmas) and q{sub 95} = 2 (divertor plasmas). However, passively stable operation can be attained for q(a) and q{sub 95} values as low as 2.2. RWM damping in the q(a) = 2 regime was measured using active MHD spectroscopy. Although consistent with theoretical predictions, the amplitude of the damped response does not increase significantly as the q(a) = 2 limit is approached, in contrast with damping measurements made approaching the pressure-driven RWM limit. Applying proportional gain magnetic feedback control of the n = 1 modes has resulted in stabilized operation with q{sub 95} values reaching as low as 1.9 in DIII-D and q(a) reaching 1.55 in RFX-mod. In addition to being consistent with the q(a) = 2 external kink mode stability limit, the unstable modes have growth rates on the order of the characteristic wall eddy-current decay timescale in both devices, and a dominant m = 2 poloidal structure that is consistent with ideal MHD predictions. The experiments contribute to validating MHD stability theory and demonstrate that a key tokamak stability limit can be overcome with feedback.

  14. Effect of gamma-irradiation for shelf life extension of chicken meat

    Energy Technology Data Exchange (ETDEWEB)

    Prachasitthisak, Y. [Office of Atomic Energy for Peace, Bangkok (Thailand); Ito, Hitoshi

    1996-09-01

    On the study of microbiological quality of 12 samples of chicken meat produced in several different area in Japan, total aerobic bacteria were determined as 8x10{sup 4} to 5x10{sup 7} per g. Coliforms were 8x10{sup 1} to 3x10{sup 4} per g with Escherichia, Proteus and Klebsiella. Dominant putrefactive bacteria were determined as lactic acid bacteria, Pseudomonas and Flavobacterium. The shelf life of irradiated chicken meat at 1 kGy extended more than 6 days at 10degC storage. Irradiation of chicken meat at 3 kGy extended 12 days. Coliforms were disappeared at 1 kGy irradiation. (author)

  15. Extreme life extension: investing in cryonics for the long, long term.

    Science.gov (United States)

    Romain, Tiffany

    2010-04-01

    This article explores American conceptualizations of finance, the future, the limits of biological time, and the possibilities of biotechnoscience through an investigation of the social world of cryonics-the freezing of the dead with the hope of future revival. I describe some of the cosmologies of life, death, time, and the management of the future that circulate within cryonics communities, and I draw out relationships between cryonics practices and discourses and more common forms of personal future management prevalent within American neoliberal capitalism. I also illustrate similarities and differences between cryonics and more mainstream biomedical technologies. In doing so, I argue that cryonics is one American manifestation of anxieties about aging, time, and the future. I investigate the impact of biotechnologies on self-making and biosociality, and argue that crafting of selves can be deeply entwined with practices of investment or hope in the future of biomedicine and technology.

  16. Transitions in waste treatment as a driver for product life extension

    DEFF Research Database (Denmark)

    Lauridsen, Erik Hagelskjær; Jørgensen, Michael Søgaard

    2015-01-01

    Increasing amounts of energy are used for provision of resources. Recycling, refurbishment and reuse practices are recurring elements in visions of the future low carbon and resource efficient society. Visions of improved waste management practices are, however, confronted with the inherent...... waste treatment process. Previously improved treatment of waste was perceived as closely linked to waste incineration technology and widely shielded from the contextualisation of demands for increased reuse, recycling and improved resource efficiency. This regime seems now gradually to become somewhat...... that emphasise prolonged product life and stresses the importance of avoiding down cycling of products and material streams. The destabilisation of the old incineration regime thus opens up for new opportunities with both new policies and potentially new social practices. This paper describes a number...

  17. Safe extension of red blood cell storage life at 4{degree}C

    Energy Technology Data Exchange (ETDEWEB)

    Bitensky, M.; Yoshida, Tatsuro

    1996-04-01

    The project sought to develop methods to extend the storage life of red blood cells. Extended storage would allow donor to self or autologous transfusion, expand and stabilize the blood supply, reduce the cost of medical care and eliminate the risk of transfusion related infections, including a spectrum of hepatitides (A, B and C) and HIV. The putative cause of red blood cell spoilage at 4 C has been identified as oxidative membrane damage resulting from deoxyhemoglobin and its denaturation products including hemichrome, hemin and Fe{sup 3+}. Trials with carbon monoxide, which is a stabilizer of hemoglobin, have produced striking improvement of red blood cell diagnostics for cells stored at 4 C. Carbonmonoxy hemoglobin is readily converted to oxyhemoglobin by light in the presence of oxygen. These findings have generated a working model and an approach to identify the best protocols for optimal red cell storage and hemoglobin regeneration.

  18. Shelf Life Extension of Maple pea (Pisum sativum var. arvense L. Spread Using Sous Vide

    Directory of Open Access Journals (Sweden)

    Ķirse Asnate

    2016-12-01

    Full Text Available The aim of this study was to determine the effect of sous vide packaging on the shelf life of maple pea (Pisum sativum var. arvense L. spread. Pea spreads were made of ground re-hydrated cooked maple peas ‘Bruno’ (Pisum sativum var. arvense L., to which salt, citric acid, oil, and spices were added. Pea spread was stored in polyamide/polyethylene (PA/PE film pouches, packaged in vacuum and hermetically sealed. Pea spread pouches were heat treated in a water bath, then rapidly cooled in ice-water and stored at 4.0 ± 0.5 °C. Sous vide was applied in three different heat regimens +(65.0; 80.0 and 100.0 ± 0.5 °C with cooking times 5, 10, 15, 20, 25, and 30 min at a constant temperature. Total plate count was determined according to ISO 4833-1:2014 on Plate Count Agar and Enterobacteriaceae determination was performed in accordance with ISO 21528-2:2004 on Violet Red Bile Glucose Agar. Total plate count in pea spread without thermal treatment was 3.41 log10 CFU g−1, in all sous vide packaged pea spread samples microbial contamination was significantly lower (p < 0.05. Enterobacteriaceae were not detected in any samples. It is possible to extend the shelf life of sous vide maple pea spread up to 14 weeks when stored at 4.0 ± 0.5 °C.

  19. The worker honeybee fat body proteome is extensively remodeled preceding a major life-history transition.

    Directory of Open Access Journals (Sweden)

    Queenie W T Chan

    Full Text Available Honeybee workers are essentially sterile female helpers that make up the majority of individuals in a colony. Workers display a marked change in physiology when they transition from in-nest tasks to foraging. Recent technological advances have made it possible to unravel the metabolic modifications associated with this transition. Previous studies have revealed extensive remodeling of brain, thorax, and hypopharyngeal gland biochemistry. However, data on changes in the abdomen is scarce. To narrow this gap we investigated the proteomic composition of abdominal tissue in the days typically preceding the onset of foraging in honeybee workers. In order to get a broader representation of possible protein dynamics, we used workers of two genotypes with differences in the age at which they initiate foraging. This approach was combined with RNA interference-mediated downregulation of an insulin/insulin-like signaling component that is central to foraging behavior, the insulin receptor substrate (irs, and with measurements of glucose and lipid levels. Our data provide new insight into the molecular underpinnings of phenotypic plasticity in the honeybee, invoke parallels with vertebrate metabolism, and support an integrated and irs-dependent association of carbohydrate and lipid metabolism with the transition from in-nest tasks to foraging.

  20. EXPERIENCES OF OPERATING AND STUDYING IN SECOND LIFE: STUDYING IN SECOND LIFE:

    Directory of Open Access Journals (Sweden)

    Riitta LISKI

    2011-08-01

    Full Text Available The Educational Association Citizens´ Forum SKAF ry is an educational institution for non-formal education. The Citizens’ Forum has been an active Second Life participant since 2007, researching its potential and challenges in educational use and non-governmental organisation activities. The first training sessions were organised in 2008 on a block of land rented from EduFinland I island. Later, ownership was acquired of the Suomi ry (Finland ry island, which was customised to serve Finnish organisations and non-governmental organisations (further NGO. The Citizens’ Forum’s training courses have covered training in Second Life and the organisation of cooperative meetings and various other events in Second Life. The overall length of training sessions has been one month. Each course has consisted of 3-5. 1.5 hour meetings in Second Life and interim tasks completed either individually or in small groups. In addition to Second Life, Moodle, an online learning environment, has been employed in which tasks, experiences and feedback have been gathered and which has also contained written summaries of what was learned during the Second Life meetings. The Second Life environment has also been regularly utilised in Citizens’ Forum staff and various other work group work related meetings.Funding and ventures 2008: Ministry of Education special funding, Initiation of Second Life courses and construction of environment 2009-2010: ESF programme Open Learning Environments-AVO venture, development and implementation of Second Life educational programmes.This article is based on practical experiences gained from Ø suitability of cooperative educational processes for Second LifeØ constructing a Second Life environment for educational useØ suitability of Second Life technology and tools for education and team workØ practical methods related to educational situations .

  1. Extension of market concept with market-driven optimisation of distribution system operation

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Østergaard, Jacob

    2013-01-01

    This report describes the development of a pricing mechanism for the alleviation of congestion at the 10kV distribution network level using demand flexibility in a 5-minute real-time market environment. Demand was incorporated into an OPF based market clearing procedure in which demand bids were...... not explicitly submitted, but derived from historic demand response behaviour. The locational prices resulting from this local optimisation were used to alleviate the congestion that would result from response to a global price, as issued within the EcoGrid EU real time market for system balancing services from...... distributed resources. A complementary direct control framework was developed to operate in tandem with the pricing mechanism to ensure the reliable alleviation of congestion...

  2. Sex-specific Tradeoffs With Growth and Fitness Following Life-span Extension by Rapamycin in an Outcrossing Nematode, Caenorhabditis remanei.

    Science.gov (United States)

    Lind, Martin I; Zwoinska, Martyna K; Meurling, Sara; Carlsson, Hanne; Maklakov, Alexei A

    2016-07-01

    Rapamycin inhibits the nutrient-sensing TOR pathway and extends life span in a wide range of organisms. Although life-span extension usually differs between the sexes, the reason for this is poorly understood. Because TOR influences growth, rapamycin likely affects life-history traits such as growth and reproduction. Sexes have different life-history strategies, and theory predicts that they will resolve the tradeoffs between growth, reproduction, and life span differently. Specifically, in taxa with female-biased sexual size dimorphism, reduced growth may have smaller effects on male fitness. We investigated the effects of juvenile, adult, or life-long rapamycin treatment on growth, reproduction, life span, and individual fitness in the outcrossing nematode Caenorhabditis remanei Life-long exposure to rapamycin always resulted in the strongest response, whereas postreproductive exposure did not affect life span. Although rapamycin resulted in longer life span and smaller size in males, male individual fitness was not affected. In contrast, size and fitness were negatively affected in females, whereas life span was only extended under high rapamycin concentrations. Our results support the hypothesis that rapamycin affects key life-history traits in a sex-specific manner. We argue that the fitness cost of life-span extension will be sex specific and propose that the smaller sex generally pay less while enjoying stronger life-span increase.

  3. Extension shelf life of batte by using hydrocolloids and gamma irradiation

    Directory of Open Access Journals (Sweden)

    Mervat M. Anwar

    2015-10-01

    Full Text Available Batte (is baked french one of the most baked coated most prevalent in the markets after the cake wrapping. Batte exposed generally two types of corruption which is occurring phenomenon of (anti-staling and corruption microbial (molds. In this study produced batte with an attempt to prolong the period of its validity by addition 1.5% hydrocolloids, (which is 0.5% sodium alginate, 0.5% k-carrageenan and 0.5% hydroxyl propyl methylcellulose (HPMC to hard wheat flour 72% (HWF to improve materials for mellowness and anti-staling, whereas batte exposed to gamma irradiation at doses 0.5, 1, 1.5, 2, 3 and 5 kGy to decrease microbial load. Hydrocolloids at 1.5% improved the rheological properties of dough farinogragh and aextensograph parameters. The hydrocolloids increase flexibility, rubber and freshness of batte to 24 days compared to 8 days in control sample. Thiobarbituric acid (T.B.A values at the end of storage at room temperature (ranged to 0.253–0.352 mg malonaldehyde/kg that were less than these mentioned by the Egyptian Standard. Also, gamma irradiation reduced the total bacterial count of batte product. Sensory evaluation of produced batte was done. The addition of 1.5% hydrocolloids and exposed to gamma irradiation had higher freshness and increase shelf-life for 20, 25, 30, 35 and 40 days against only 15 days for control sample.

  4. Improvement of mechanical properties and life extension of high reliability structural components by laser shock processing

    Science.gov (United States)

    Ocaña, J. L.; Morales, M.; Porro, J. A.; Iordachescu, D.; Díaz, M.; Ruiz de Lara, L.; Correa, C.

    2011-05-01

    Profiting by the increasing availability of laser sources delivering intensities above 109 W/cm2 with pulse energies in the range of several Joules and pulse widths in the range of nanoseconds, laser shock processing (LSP) is being consolidating as an effective technology for the improvement of surface mechanical and corrosion resistance properties of metals and is being developed as a practical process amenable to production engineering. The main acknowledged advantage of the laser shock processing technique consists on its capability of inducing a relatively deep compression residual stresses field into metallic alloy pieces allowing an improved mechanical behaviour, explicitly, the life improvement of the treated specimens against wear, crack growth and stress corrosion cracking. Following a short description of the theoretical/computational and experimental methods developed by the authors for the predictive assessment and experimental implementation of LSP treatments, experimental results on the residual stress profiles and associated surface properties modification successfully reached in typical materials (specifically Al and Ti alloys) under different LSP irradiation conditions are presented. In particular, the analysis of the residual stress profiles obtained under different irradiation parameters and the evaluation of the corresponding induced surface properties as roughness and wear resistance are presented.

  5. A study and extension of second-order blind source separation to operational modal analysis

    Science.gov (United States)

    Antoni, J.; Chauhan, S.

    2013-02-01

    Second-order blind source separation (SOBSS) has gained recent interest in operational modal analysis (OMA), since it is able to separate a set of system responses into modal coordinates from which the system poles can be extracted by single-degree-of-freedom techniques. In addition, SOBSS returns a mixing matrix whose columns are the estimates of the system mode shapes. The objective of this paper is threefold. First, a theoretical analysis of current SOBSS methods is conducted within the OMA framework and its precise conditions of applicability are established. Second, a new separation method is proposed that fixes current limitations of SOBSS: It returns estimate of complex mode shapes, it can deal with more active modes than the number of available sensors, and it shows superior performance in the case of heavily damped and/or strongly coupled modes. Third, a theoretical connection is drawn between SOBSS and stochastic subspace identification (SSI), which stands as one of the points of reference in OMA. All approaches are finally compared by means of numerical simulations.

  6. Feasibility for Orbital Life Extension of a CubeSat in the Lower Thermosphere

    Science.gov (United States)

    Blandino, John J.; Martinez-Baquero, Nicolas; Demetriou, Michael A.; Gatsonis, Nikolaos A.; Paschalidis, Nicholas

    2016-01-01

    Orbital flight of CubeSats at altitudes between 150 and 250 km has the potential to enable a new class of scientific, commercial, and defense-related missions. A study is presented to demonstrate the feasibility of extending the orbital lifetime of a CubeSat in a 210 km orbit. Propulsion consists of an electrospray thruster operating at a 2 W, 0.175 mN thrust, and an specific impulse (Isp) of 500 s. The mission consists of two phases. In phase 1, the CubeSat is deployed from a 414 km orbit and uses the thruster to deorbit to the target altitude of 210 km. In phase 2, the propulsion system is used to extend the mission lifetime until propellant is fully expended. A control algorithm based on maintaining a target orbital energy is presented that uses an extended Kalman filter to generate estimates of the orbital dynamic state, which are periodically updated by Global Positioning System measurements. For phase 1, the spacecraft requires 25.21 days to descend from 414 to 210 km, corresponding to a delta V = 96.25 m/s and a propellant consumption of 77.8 g. Phase 2 lasts 57.83 days, corresponding to a delta V = 119.15 m/s, during which the remaining 94.2 g of propellant are consumed.

  7. Extension gap needs more than 1-mm laxity after implantation to avoid post-operative flexion contracture in total knee arthroplasty.

    Science.gov (United States)

    Okamoto, Shigetoshi; Okazaki, Ken; Mitsuyasu, Hiroaki; Matsuda, Shuichi; Mizu-Uchi, Hideki; Hamai, Satoshi; Tashiro, Yasutaka; Iwamoto, Yukihide

    2014-12-01

    In total knee arthroplasty (TKA), a high soft-tissue tension in extension at the time of operation would cause a post-operative flexion contracture. However, how tight the extension gap should be during surgery to avoid a post-operative flexion contracture remains unclear. The hypothesis is that some laxity in the intraoperative extension gap is necessary to avoid the post-operative flexion contracture. A posterior-stabilized TKA was performed for 75 osteoarthritic knees with a varus deformity. The intraoperative extension gap was measured using a tensor device that provides the gap length and the angle between the femoral component and the tibial cut surface. The medial component gap was defined as the gap calculated by subtracting the selected thickness of the tibial component, including the polyethylene liner, from the extension gap at the medial side. Then, the patients were divided into three groups according to the medial component gap, and post-operative extension angle measured 1 year after the surgery was compared between each groups. One year post-operatively, a flexion contracture of more than 5° was found in 0/34 patients when the medial component gap was more than 1 mm, in 2/26 (8%) patients when the gap was between 0 and 1 mm, and in 3/15 (20%) patients when the gap was contracture. As a clinical relevance, this study clarified the optimal extension gap to avoid the post-operative flexion contracture. Prospective comparative study, Level II.

  8. The essence of reliability estimation during operational life for achieving high system dependability

    NARCIS (Netherlands)

    Khan, M.A.; Kerkhoff, Hans G.

    2013-01-01

    System dependability has become important for critical applications in recent years as technology is moving towards smaller dimensions. Achieving high dependability can be supported by reliability estimations during the operational life. In addition this requires a workflow for regularly monitoring

  9. The essence of reliability estimation during operational life for achieving high system dependability

    NARCIS (Netherlands)

    Khan, Muhammad Aamir; Kerkhoff, Hans G.

    2013-01-01

    System dependability has become important for critical applications in recent years as technology is moving towards smaller dimensions. Achieving high dependability can be supported by reliability estimations during the operational life. In addition this requires a workflow for regularly monitoring

  10. A continuous labour supply model in microsimulation: a life-cycle modelling approach with heterogeneity and uncertainty extension.

    Directory of Open Access Journals (Sweden)

    Jinjing Li

    Full Text Available This paper advances a structural inter-temporal model of labour supply that is able to simulate the dynamics of labour supply in a continuous setting and addresses two main drawbacks of most existing models. The first limitation is the inability to incorporate individual heterogeneity as every agent is sharing the same parameters of the utility function. The second one is the strong assumption that individuals make decisions in a world of perfect certainty. Essentially, this paper offers an extension of marginal-utility-of-wealth-constant labour supply functions known as "Frisch functions" under certainty and uncertainty with homogenous and heterogeneous preferences. The lifetime models based on the fixed effect vector decomposition yield the most stable simulation results, under both certain and uncertain future wage assumptions. Due to its improved accuracy and stability, this lifetime labour supply model is particularly suitable for enhancing the performance of the life cycle simulation models, thus providing a better reference for policymaking.

  11. A continuous labour supply model in microsimulation: a life-cycle modelling approach with heterogeneity and uncertainty extension.

    Science.gov (United States)

    Li, Jinjing; Sologon, Denisa Maria

    2014-01-01

    This paper advances a structural inter-temporal model of labour supply that is able to simulate the dynamics of labour supply in a continuous setting and addresses two main drawbacks of most existing models. The first limitation is the inability to incorporate individual heterogeneity as every agent is sharing the same parameters of the utility function. The second one is the strong assumption that individuals make decisions in a world of perfect certainty. Essentially, this paper offers an extension of marginal-utility-of-wealth-constant labour supply functions known as "Frisch functions" under certainty and uncertainty with homogenous and heterogeneous preferences. The lifetime models based on the fixed effect vector decomposition yield the most stable simulation results, under both certain and uncertain future wage assumptions. Due to its improved accuracy and stability, this lifetime labour supply model is particularly suitable for enhancing the performance of the life cycle simulation models, thus providing a better reference for policymaking.

  12. Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.

    Science.gov (United States)

    Reverter-Branchat, Gemma; Cabiscol, Elisa; Tamarit, Jordi; Sorolla, M Alba; Angeles de la Torre, M; Ros, Joaquim

    2007-11-01

    Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol, regenerating NAD+. In Saccharomyces cerevisiae, Adh1p is oxidatively modified during ageing and, consequently, its activity becomes reduced. To analyse whether maintaining this activity is advantageous for the cell, a yeast strain with an extra copy of the ADH1 gene (2xADH1) was constructed, and the effects on chronological and replicative ageing were analysed. The strain showed increased survival in stationary phase (chronological ageing) due to induction of antioxidant enzymes such as catalase and superoxide dismutases. In addition, 2xADH1 cells displayed an increased activity of silent information regulator 2 (Sir2)p, an NAD+-dependent histone deacetylase, due to a higher NAD+/NADH ratio. As a consequence, a 30% extension in replicative life span was observed. Taken together, these results suggest that the maintenance of enzymes that participate in NAD+/NADH balancing is important to chronological and replicative life-span parameters.

  13. Coherent Synchrotron Radiation A Simulation Code Based on the Non-Linear Extension of the Operator Splitting Method

    CERN Document Server

    Dattoli, Giuseppe

    2005-01-01

    The coherent synchrotron radiation (CSR) is one of the main problems limiting the performance of high intensity electron accelerators. A code devoted to the analysis of this type of problems should be fast and reliable: conditions that are usually hardly achieved at the same time. In the past, codes based on Lie algebraic techniques have been very efficient to treat transport problem in accelerators. The extension of these method to the non-linear case is ideally suited to treat CSR instability problems. We report on the development of a numerical code, based on the solution of the Vlasov equation, with the inclusion of non-linear contribution due to wake field effects. The proposed solution method exploits an algebraic technique, using exponential operators implemented numerically in C++. We show that the integration procedure is capable of reproducing the onset of an instability and effects associated with bunching mechanisms leading to the growth of the instability itself. In addition, parametric studies a...

  14. Implementing an extension of the analytical hierarchy process using ordered weighted averaging operators with fuzzy quantifiers in ArcGIS

    Science.gov (United States)

    Boroushaki, Soheil; Malczewski, Jacek

    2008-04-01

    This paper focuses on the integration of GIS and an extension of the analytical hierarchy process (AHP) using quantifier-guided ordered weighted averaging (OWA) procedure. AHP_OWA is a multicriteria combination operator. The nature of the AHP_OWA depends on some parameters, which are expressed by means of fuzzy linguistic quantifiers. By changing the linguistic terms, AHP_OWA can generate a wide range of decision strategies. We propose a GIS-multicriteria evaluation (MCE) system through implementation of AHP_OWA within ArcGIS, capable of integrating linguistic labels within conventional AHP for spatial decision making. We suggest that the proposed GIS-MCE would simplify the definition of decision strategies and facilitate an exploratory analysis of multiple criteria by incorporating qualitative information within the analysis.

  15. Extended Aging Theories for Predictions of Safe Operational Life of Critical Airborne Structural Components

    Science.gov (United States)

    Ko, William L.; Chen, Tony

    2006-01-01

    The previously developed Ko closed-form aging theory has been reformulated into a more compact mathematical form for easier application. A new equivalent loading theory and empirical loading theories have also been developed and incorporated into the revised Ko aging theory for the prediction of a safe operational life of airborne failure-critical structural components. The new set of aging and loading theories were applied to predict the safe number of flights for the B-52B aircraft to carry a launch vehicle, the structural life of critical components consumed by load excursion to proof load value, and the ground-sitting life of B-52B pylon failure-critical structural components. A special life prediction method was developed for the preflight predictions of operational life of failure-critical structural components of the B-52H pylon system, for which no flight data are available.

  16. A Venus Rover Capable of Long Life Surface Operations

    Science.gov (United States)

    Evans, M.; Shirley, J. H.; Abelson, R. D.

    2005-12-01

    Access to the surface of Venus would allow planetary scientists to address a number of currently open questions. Among these are the elemental and mineralogical composition of the surface; the interaction of the surface with the atmosphere; the atmospheric composition, especially isotope ratios of key species; the nature of the planetary volcanism (present activity, emissions to the atmosphere, and composition); planetary seismicity; the local surface meteorology (winds and pressure variability); and the surface geology and morphology at particular locations on the surface. A long lived Venus rover mission could be enabled by utilizing a novel Stirling engine system for both cooling and electric power. Previous missions to the Venus surface, including the Pioneer Venus and Venera missions, survived for only a few hours. The rover concept described in the present study is designed for a surface lifetime of 60 days, with the potential of operating well beyond that. A Thermo-Acoustic Stirling Heat Engine (TASHE) would convert the high-temperature (~1200 °C) heat from General Purpose Heat Source (GPHS) modules into acoustic power which then drives a linear alternator and a pulse tube cooler to provide electric power and remove the large environmental heat load. The "cold" side of the engine would be furnished by the ambient atmosphere at 460 °C. This short study focused on the feasibility of using the TASHE system in this hostile environment to power a ~650 kg rover that would provide a mobile platform for science measurements. The instrument suite would collect data on atmospheric and surface composition, surface stratigraphy, and subsurface structure. An Earth-Venus-Venus trajectory would be used to deliver the rover to a low entry angle allowing an inflated ballute to provide a low deceleration and low heat descent to the surface. All rover systems would be housed in a pressure vessel in vacuum with the internal temperature maintained by the TASHE below 50 °C. No

  17. Certain issues about unexpected ejection of gas and life saving operations

    Energy Technology Data Exchange (ETDEWEB)

    Kristian, B.; Szazados, I.

    1984-01-01

    Prerequisites for sudden ejections of methane are examined, along with measures to prevent its spread along mine drifts in the coal mines of Hungary (VNR). Light is shed on the problems of saving people who end up in dangerous zones and for organizing operations to prepare and train miners in life saving operations. Experience in the organization of such operations in the mines of the Mechek coal basin showed their practical expedience.

  18. Resveratrol and life extension

    National Research Council Canada - National Science Library

    Agarwal, Beamon; Baur, Joseph A

    2011-01-01

    .... The polyphenol resveratrol activates SIRT1 in an in vitro assay, and produces changes that resemble CR in vivo , including improvements in insulin sensitivity, endurance, and overall survival in obese mice...

  19. Operational plans for life science payloads - From experiment selection through postflight reporting

    Science.gov (United States)

    Mccollum, G. W.; Nelson, W. G.; Wells, G. W.

    1976-01-01

    Key features of operational plans developed in a study of the Space Shuttle era life science payloads program are presented. The data describes the overall acquisition, staging, and integration of payload elements, as well as program implementation methods and mission support requirements. Five configurations were selected as representative payloads: (a) carry-on laboratories - medical emphasis experiments, (b) mini-laboratories - medical/biology experiments, (c) seven-day dedicated laboratories - medical/biology experiments, (d) 30-day dedicated laboratories - Regenerative Life Support Evaluation (RLSE) with selected life science experiments, and (e) Biomedical Experiments Scientific Satellite (BESS) - extended duration primate (Type I) and small vertebrate (Type II) missions. The recommended operational methods described in the paper are compared to the fundamental data which has been developed in the life science Spacelab Mission Simulation (SMS) test series. Areas assessed include crew training, experiment development and integration, testing, data-dissemination, organization interfaces, and principal investigator working relationships.

  20. Operational plans for life science payloads - From experiment selection through postflight reporting

    Science.gov (United States)

    Mccollum, G. W.; Nelson, W. G.; Wells, G. W.

    1976-01-01

    Key features of operational plans developed in a study of the Space Shuttle era life science payloads program are presented. The data describes the overall acquisition, staging, and integration of payload elements, as well as program implementation methods and mission support requirements. Five configurations were selected as representative payloads: (a) carry-on laboratories - medical emphasis experiments, (b) mini-laboratories - medical/biology experiments, (c) seven-day dedicated laboratories - medical/biology experiments, (d) 30-day dedicated laboratories - Regenerative Life Support Evaluation (RLSE) with selected life science experiments, and (e) Biomedical Experiments Scientific Satellite (BESS) - extended duration primate (Type I) and small vertebrate (Type II) missions. The recommended operational methods described in the paper are compared to the fundamental data which has been developed in the life science Spacelab Mission Simulation (SMS) test series. Areas assessed include crew training, experiment development and integration, testing, data-dissemination, organization interfaces, and principal investigator working relationships.

  1. Shelf-life extension of minimally processed and gamma irradiated red beet (Beta vulgaris ssp. vulgaris L.), Cv. early wonder

    Energy Technology Data Exchange (ETDEWEB)

    Hernandes, Nilber Kenup; Vital, Helio de Carvalho [Centro Tecnologico do Exercito (CTEx), Rio de Janeiro, RJ (Brazil). Div. de Defesa Quimica, Biologica e Nuclear (DDQBN)]. E-mail: nilberkenup@ctex.eb.br; vital@ctex.eb.br; Coneglian, Regina Celi Cavestre [Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropedica, Rio de Janeiro, RJ (Brazil). Inst.de Agronomia. Dept. de Fitotecnia]. E-mail: rccconeg@ufrrj.br; Godoy, Ronoel Luiz de Oliveira [EMBRAPA Agroindustria de Alimentos, Rio de Janeiro, RJ (Brazil)]. E-mail: ronoel@ctaa.embrapa.br

    2007-07-01

    This work investigated the effects of gamma irradiation on the shelf-life extension and safety of minimally processed red beet (Beta vulgaris ssp. vulgaris L.) by performing microbiological, chemical and sensory analyses. Red beets were harvested 73 days after transplanting and their tuberous parts were minimally processed and separated in two groups: control (non-irradiated) and irradiated (0.5, 1.0 and 1.5 kGy). Tests for Salmonella sp., total and fecal coliforms, total count of aerobic mesophilic and lactic-acid bacteria were performed during the 21-day storage at 8 deg C. They indicated that the samples irradiated with 1.0 and 1.5 kGy remained in good conditions throughout storage while the unirradiated samples did not last 7 days. Chemical analyses indicated that the concentrations of vitamins B1 and B2 were not affected by irradiation. In contrast the amounts of fructose and glucose increased during storage while the one for sucrose decreased. In addition four series of sensory evaluations including appearance and aroma indicated that the samples irradiated with 1.0 and 1.5 kGy remained good for consumption for 20 days. Therefore it was concluded that the use of the doses of 1.0 and 1.5 kGy produced the best effects on the conservation of the samples without harming the sensory characteristics and nutritional constituents tested. (author)

  2. Shelf life extension of ricotta cheese using coatings of galactomannans from nonconventional sources incorporating nisin against Listeria monocytogenes.

    Science.gov (United States)

    Martins, Joana T; Cerqueira, Miguel A; Souza, Bartolomeu W S; Carmo Avides, Maria do; Vicente, António A

    2010-02-10

    Shelf life extension of Ricotta cheese was evaluated at 4 degrees C upon the use of edible coatings made of galactomannans from Gleditsia triacanthos incorporating nisin against Listeria monocytogenes. Three different treatments were tested in cheese: samples without coating; samples with coating without nisin; and samples with coating containing 50 IU x g(-1) of nisin. To test the effectiveness of the treatments against L. monocytogenes, the surface of the cheese was inoculated with a suspension of the microorganism. Microbiological and physical-chemical analyses of the cheese samples were performed during 28 days. Results showed that the cheese coated with nisin-added galactomannan film was the treatment presenting the best results in terms of microbial growth delay (p < 0.05). The addition of nisin also affects (p < 0.05) the physical and mechanical properties of the films: O(2) permeability decreased from 1.84 to 1.35 x 10(-12) cm(3) x (Pa x s x m)(-1); CO(2) permeability increased from 1.96 to 6.31 x 10(-12) cm(3).(Pa x s x m)(-1); opacity increased from 3.68 to 4.59%; tensile strength ranged from 0.84 to 1.46 MPa; and elongation at break improved from 50.93 to 68.16%. These results demonstrate that novel galactomannan-based edible coatings, when combined with nisin, may provide consumer-friendly alternatives to reduce L. monocytogenes postcontamination on cheese products during storage.

  3. Life Cycle Assessment of Slop Water Management in Challenging Offshore Drilling Operations

    OpenAIRE

    Okiemute, Anthony

    2015-01-01

    Abstract Offshore oil and gas drilling operations generates slop water, which are formed when wastewater originating from multiple sources becomes contaminated with drilling fluid components and have to be disposed or treated prior to discharge in compliance with local discharge regulations. The logistics and treatment of slop water have been suggested to represent a significant part of the life-cycle environmental footprint of offshore drilling operations but poorly understood due to lac...

  4. Meeting a Growing Demand: Texas A&M AgriLife Extension Service's Early Childhood Educator Online Training Program

    Science.gov (United States)

    Green, Stephen

    2013-01-01

    Demand for professional development training in the early childhood field has grown substantially in recent years. To meet the demand, Texas A&M AgriLife Extension Service's Family Development and Resource Management unit developed the Early Childhood Educator Online Training Program, a professional development system that currently…

  5. An indirect technique for estimating reliability of analog and mixed-signal systems during operational life

    NARCIS (Netherlands)

    Khan, M.A.; Kerkhoff, Hans G.

    2013-01-01

    Reliability of electronic systems has been thoroughly investigated in literature and a number of analytical approaches at the design stage are already available via examination of the circuit-level reliability effects based on device-level models. Reliability estimation during operational life of an

  6. An indirect technique for estimating reliability of analog and mixed-signal systems during operational life

    NARCIS (Netherlands)

    Khan, Muhammad Aamir; Kerkhoff, Hans G.

    2013-01-01

    Reliability of electronic systems has been thoroughly investigated in literature and a number of analytical approaches at the design stage are already available via examination of the circuit-level reliability effects based on device-level models. Reliability estimation during operational life of an

  7. Useful life extension of steam-turbine elements by means of welding processes; Extension de la vida util de los elementos de las turbinas de vapor mediante procesos de soldadura

    Energy Technology Data Exchange (ETDEWEB)

    Mazur Czerwiec, Zdzislaw; Cristalinas Navarro, Victor Manuel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1994-03-01

    The elements of the flow system in the steam turbines are subjected to a natural or accelerated wear during their operation. The stationary and the rotating blades are parts of the turbine that present damages, faults or materials wear, after some service periods, that can be from mechanical or metallurgical origin and prevent its continuous operation. This is also revealed in the equipment availability, reliability and performance diminution. Several cases are presented of recovery, and useful life extension of worn stationary blades (nozzle blocks and diaphragms), and rotating blades by means of welding processes executed in several fossil fuel power plants of Comision Federal de Electricidad. For each specific case, wear type or damage, the special processes based in welding processes, were developed. The blade recovery process also includes: the stress relieving, machining, special coating, quality control and tool design. Once the recovery process is completed, the components were installed back in the turbines for their utilization. The application of the welding technologies developed for blade recovery, represents just a fraction of the cost of new blades, that results in an economic saving. [Espanol] Los elementos del sistema de flujo de las turbinas de vapor sufren un desgaste natural o acelerado durante su operacion. Los alabes fijos y moviles son las partes de la turbina que despues de ciertos periodos de servicio presentan danos, fallas o desgaste del material que pueden ser de origen mecanico o metalurgico y no permiten su operacion continua. Esto se refleja tambien en la disminucion de la disponibilidad, confiabilidad y rendimiento del equipo. Se presentan varios casos de recuperacion y prolongacion de la vida util de alabes fijos (bloques de toberas y diafragmas) y moviles danados y gastados a causa de procesos de soldadura que se llevaron a cabo en varias plantas termoelectricas de la Comision Federal de Electricidad. Para cada caso especifico

  8. A close examination of under-actuated attitude control subsystem design for future satellite missions' life extension

    Science.gov (United States)

    Lam, Quang M.; Barkana, Itzhak

    2014-12-01

    Satellite mission life, maintained and prolonged beyond its typical norm of their expectancy, are primarily dictated by the state of health of its Reaction Wheel Assembly (RWA), especially for commercial GEO satellites since torquer bars are no longer applicable while thruster assistant is unacceptable due to pointing accuracy impact during jet firing. The RWA is the primary set of actuators (as compared to thrusters for orbit maintenance and maneuvering) mainly responsible for the satellite mission for accurately and precisely pointing its payloads to the right targets to conduct its mission operations. The RWA consisting of either a set of four in pyramid or three in orthogonal is the primary set of actuators to allow the satellite to achieve accurate and precise pointing of the satellite payloads towards the desired targets. Future space missions will be required to achieve much longer lives and are currently perceived by the GEO satellite community as an "expected norm" of 20 years or longer. Driven by customers' demands/goals and competitive market have challenged Attitude Control Subsystems (ACS) engineers to develop better ACS algorithms to address such an emerging need. There are two main directions to design satellite's under-actuated control subsystem: (1) Attitude Feedback with Zero Momentum Principle and (2) Attitude Control by Angular Velocity Tracking via Small Time Local Controllability concept. Successful applications of these control laws have been largely demonstrated via simulation for the rest to rest case. Limited accuracy and oscillatory behaviors are observed in three axes for non-zero wheel momentum while realistic loss of a wheel scenario (i.e., fully actuated to under-actuated) has not been closely examined! This study revisits the under-actuated control design with detailed set ups of multiple scenarios reflecting real life operating conditions which have put current under-actuated control laws mentioned earlier into a re-evaluation mode

  9. Analysis on Service Life of Hot-end Components of Gas Turbine Using Equivalent Operation

    Directory of Open Access Journals (Sweden)

    Taixing Wang

    2013-01-01

    Full Text Available The reliability of the gas turbine depends on the technical status and the maintenance level of the hot-end components in a large part.The three main factors influencing on the service life of the hot-end components of the gas turbine were analyzed first.On this basis,various common service life assessment methods for gas turbine were discussed in detail.Aiming at the features of the M701F gas-steam combined cycle unit in Huizhou LNG power plant,a gas turbine life assessment method based on equivalent operation time analysis was put forward.The calculation result of an example shows that the equivalent operation time analysis method is a simple and practical assessment method.

  10. Gas spark switches with increased operating life for Marx generator of lightning test complex

    Energy Technology Data Exchange (ETDEWEB)

    Bykov, Yu. A.; Krastelev, E. G., E-mail: ekrastelev@yandex.ru [Russian Academy of Sciences, Joint Institute for High Temperature (Russian Federation)

    2016-12-15

    A new design of gas spark switches with an increased operating life and stable dynamic characteristics for the Marx generator of the lightning test complex has been developed. The switches are characterized by the following parameters in the mode of operation: voltage up to 80 kV, discharge current up to 50 kA, flowing charge up to 3.5 C/pulse. An increased operating life is achieved by using torus-shaped electrodes with increased working surface area and a trigger electrode in the form of a thick disk with a hole located between them. Low breakdown delay time and high stability of breakdown voltage under dynamic conditions are provided by gas preionization in the spark gap using UV radiation of an additional corona discharge in the axial region.

  11. Pebble Bed Reactor Power Systems for Lunar Outposts: Long Operation Life and End-of Life Storage

    Science.gov (United States)

    El-Genk, Mohamed S.; Schriener, Timothy M.

    2010-09-01

    The Pellet Bed Reactor(PeBR) and power system for supporting future lunar outposts offer many desirable design, operation and safety features and address post operation storage of spent nuclear fuel. In addition to its long, full power operation life of 66 year, the PeBR is launched without fuel and loaded after placement below grade on the lunar surface with spherical fuel pellets, designed to fully contain fission products. The fuel pellets(~1.0 cm dia.) are launched separately in subcritical canisters. The post-operation PeBR is stored below grade for > 300 year to allow the radioactivity in the spent fuel to decay to a sufficiently low level. The PeBR power system, designed for avoidance of single point failures in reactor cooling and energy conversion, nominally generates ~100 kWe at a thermal efficiency of ~ 21%. In addition to the sectored reactor core, it uses three Closed Brayton Cycle loops with centrifugal flow turbo-machines for energy conversion and He-Xe(40 g/mol) binary gas mixture working fluid and reactor coolant.

  12. Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice

    Directory of Open Access Journals (Sweden)

    Christina B. Leibrock

    2016-02-01

    Full Text Available Background/Aims: Klotho is required for the inhibitory effect of FGF23 on 1,25(OH2D3 formation and Klotho-hypomorphic mice (kl/kl suffer from severe tissue calcification due to excessive 1,25(OH2D3 formation with subsequent increase of Ca2+ and phosphate concentrations and stimulation of osteogenic signaling. The excessive tissue calcification dramatically accelerates aging and leads to premature death of the animals. Osteogenic signaling in those mice is disrupted by treatment with NH4Cl, which prevents tissue calcification and early death of kl/kl mice. The present study explored whether the beneficial effects of NH4Cl treatment could be mimicked by NH4NO3 treatment. Methods: The kl/kl mice had free access to tap water either without or with addition of NH4NO3 (0.28 M starting with the mating of the parental generation. Calcification of trachea, lung, kidney, stomach, heart and vessels was visualized by histology with von Kossa staining. Plasma phosphate concentration was determined utilizing photometry, blood gas and electrolytes utilizing a blood Gas and Chemistry Analysis System and plasma 1,25(OH2D3 concentration with ELISA. Results: In untreated kl/kl mice plasma 1,25(OH2D3 and phosphate concentrations were elevated, and the mice suffered from marked calcification of all tissues analyzed. Untreated kl/kl mice further suffered from respiratory acidosis due to marked lung emphysema. NH4NO3-treatment decreased both, blood pCO2 and HCO3-, decreased calcification of trachea, lung, kidney, stomach, heart and vessels and increased the life span of kl/kl mice more than 1.7-fold (♂ or 1.6-fold (♀ without significantly affecting extracellular pH or plasma concentrations of 1,25(OH2D3, Ca2+, phosphate, Na+, and K+. Conclusions: NH4NO3-treatment turns respiratory acidosis into metabolic acidosis and mitigates calcification thus leading to a substantial extension of kl/kl mice survival.

  13. Environmental Control and Life Support Integration Strategy for 6-Crew Operations

    Science.gov (United States)

    Duchesne, Stephanie M.; Tressler, Chad H.

    2010-01-01

    The International Space Station (ISS) crew complement has increased in size from 3 to 6 crew members. In order to support this increase in crew on ISS, the United States on-orbit Segment (USOS) has been outfitted with a suite of regenerative Environmental Control and Life Support (ECLS) hardware including an Oxygen Generation System (OGS), Waste and Hygiene Compartment (WHC), and a Water Recovery System (WRS). The WRS includes the Urine Processor Assembly (UPA) and the Water Processor Assembly (WPA). With this additional life support hardware, the ISS has achieved full redundancy in its on-orbit life support system between the t OS and Russian Segment (RS). The additional redundancy created by the Regenerative ECLS hardware creates the opportunity for independent support capabilities between segments, and for the first time since the start of ISS, the necessity to revise Life Support strategy agreements. Independent operating strategies coupled with the loss of the Space Shuttle supply and return capabilities in 2010 offer new and unique challenges. This paper will discuss the evolution of the ISS Life Support hardware strategy in support of 6-Crew on ISS, as well as the continued work that is necessary to ensure the support of crew and ISS Program objectives through the life of station

  14. Task Shifting Provision of Contraceptive Implants to Community Health Extension Workers: Results of Operations Research in Northern Nigeria.

    Science.gov (United States)

    Charyeva, Zulfiya; Oguntunde, Olugbenga; Orobaton, Nosa; Otolorin, Emmanuel; Inuwa, Fatima; Alalade, Olubisi; Abegunde, Dele; Danladi, Saba'atu

    2015-09-01

    Contraceptive use remains low in Nigeria, with only 11% of women reporting use of any modern method. Access to long-acting reversible contraceptives (LARCs) is constrained by a severe shortage of human resources. To assess feasibility of task shifting provision of implants, we trained community health extension workers (CHEWs) to insert and remove contraceptive implants in rural communities of Bauchi and Sokoto states in northern Nigeria. We conducted 2- to 3-week training sessions for 166 selected CHEWs from 82 facilities in Sokoto state (September 2013) and 84 health facilities in Bauchi state (December 2013). To assess feasibility of the task shifting approach, we conducted operations research using a pretest-posttest design using multiple sources of information, including surveys with 151 trained CHEWs (9% were lost to follow-up) and with 150 family planning clients; facility observations using supply checklists (N = 149); direct observation of counseling provided by CHEWs (N = 144) and of their clinical (N = 113) skills; as well as a review of service statistics (N = 151 health facilities). The endline assessment was conducted 6 months after the training in each state. CHEWs inserted a total of 3,588 implants in 151 health facilities over a period of 6 months, generating 10,088 couple-years of protection (CYP). After practicing on anatomic arm models, most CHEWs achieved competency in implant insertions after insertions with 4-5 actual clients. Clinical observations revealed that CHEWs performed implant insertion tasks correctly 90% of the time or more for nearly all checklist items. The amount of information that CHEWs provided clients increased between baseline and endline, and over 95% of surveyed clients reported being satisfied with CHEWs' services in both surveys. The study found that supervisors not only observed and corrected insertion skills, as needed, during supervisory visits but also encouraged CHEWs to conduct more community

  15. The Centre for Continuing Education and Extension Services: A Legacy of Excellence and Access to Life-long Learning

    Directory of Open Access Journals (Sweden)

    Christina Rahming-Nwosa

    2015-02-01

    Full Text Available A review of the history and evolution of the Centre for Continuing Education and Extension Services and the various programmes it has developed to support the work of the College of The Bahamas.

  16. A case of industrial safety appraisal for extension of service life of GTK-10-4 gas turbines used at gas transmission stations

    Science.gov (United States)

    Rybnikov, A. I.; Kovalev, A. G.; Kryukov, I. I.; Leont'ev, S. A.; Moshnikov, A. V.

    2017-04-01

    It is shown that the extended life and enhanced operational reliability of parts and subassemblies of the most popular GTK-10-4 gas transmission plants are determined by the enhanced efficiency of the control over technical condition and operational safety of turbine plants in conformity with industrial safety requirements imposed on gas pipeline compressor stations. It has been established that the materials of parts and subassemblies of gas turbine plants with different, especially with maximal operating time, shall be exposed to NDT for the purpose of determining the actual mechanical characteristics of these materials with different operating time and calculating residual life. The analysis of damageability and operating conditions has helped to identify parts and subassemblies for repair or replacement with the highest frequency of unacceptable defects. These parts and subassemblies have been shown to include base members of the axial compressor (AC), a turbine housing, an axial compressor rotor, high- and low-pressure turbine (HPT and LPT) discs, a 12-part holder, the housing of the holder of HPT and LPT guiding blades, a sealed baffler, and working and guiding AC, LPT and HPT blades. The most typical operational defects have been enumerated and analyzed. It has been determined that the primary task of the industrial safety appraisal for extending the life of GTK-10-4 with limit-exceeding operating time is to thoroughly examine HPT and LPT discs with more than 130,000 hours of operating time and establish by DT methods characteristics of materials for evaluation, taking account of their degradation, and residual life of critical turbine elements. In addition, it has been shown that the service life of HP turbine discs can be extended by replacing the disc material (EP-428 12% chromium steel) with a material with a higher linear expansion factor that somewhat exceeds the expansion factor of EI-893 nickel alloy used to melt out working blades.

  17. Optimization of Life Cycle Extension of Asphalt Concrete Mixtures in regard to Material Properties, Structural Design, and Economic Implications

    Directory of Open Access Journals (Sweden)

    Jan Mikolaj

    2016-01-01

    Full Text Available Design of ACM life cycle is defined with respect to traffic load acting on the pavement and road class for a period of about 20 years. In practice, reconstruction is usually pending until the end of the life cycle after which the reconstruction takes place and the original materials are replaced by new materials. Life cycle of the pavement construction in road structure is significantly longer than that of the ACM; it is therefore necessary to consider ACM from a long term viewpoint, that is, exceeding their life expectancy. This paper describes a methodology which consists of analytical calculations, experimental measurements, and optimization of the ACM life cycle with the use of a rehabilitation action to provide new physical properties of pavement surfacing in different periods of the original life cycle. The aim is to attain maximal economic effectiveness, by minimizing financial costs for rehabilitation and maintenance and economic costs of road user. Presented method allows deriving optimal life cycle from various rehabilitation alternatives for particular ACM with the fact that all the necessary parameters are derived from specific experimental measurements and calculations. The method is applicable to all types of ACM materials; however, for each material, it is necessary to carry out the necessary measurements and tests. The article describes the methodology and case study results for a particular type of ACM material.

  18. Combination of glazing, nisin treatment and radiation processing for shelf-life extension of seer fish (Scomberomorous guttatus) steaks

    Science.gov (United States)

    Kakatkar, Aarti S.; Gautam, Raj Kamal; Shashidhar, Ravindranath

    2017-01-01

    Fish and fishery products are most perishable. Combination of chilling with gamma irradiation, edible coatings, addition of antimicrobials etc has been applied to extend the shelf life. In the present study, a process to enhance the shelf life of seer fish (Scomberomorus guttatus) steaks using combination of coating prepared from gel dispersion of same fish; incorporated with nisin and gamma irradiation is described. A combination of glazing incorporated with nisin and irradiation at 2 kGy and 5 kGy increased the shelf life of the steaks from 7 days up to 34 and 42 days respectively on chilled storage.

  19. Analysis of the extension and reduction method of qualified life used in equipment with ambiental qualification; Analisis del metodo de extension y reduccion de vida calificada utilizado en equipo con calificacion ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Serrano R, M.L. [CNSNS, 03020 Mexico D.F. (Mexico)].e -mail: mlserrano@cnsns.gob.mx

    2005-07-01

    With the purpose of reducing costs of acquisition, maintenance, design, hour-man, dose, production, etc. or by changes in the temperature of service, diverse Nuclear Plants (NP) in the world have been carried out extensions and reductions of life of equipment and/or components related with the safety. The used methods are mainly tests type on equipment or component aged quickly, tests type on equipment or component aged naturally and use of the Arrhenius model with monitoring of temperatures in place. The present article carries out an analysis of the Arrhenius model with monitoring of temperatures in place, which is presented in two variants, equation (1) and (2), since it is the but used by the NP with extension purposes and reduction of qualified life. As back information, it was made one search of investigations, applied to diverse fields of the science that try about the reliability of the results provided by Arrhenius for the aging case. The results of the analysis indicate: I) that this method make uncertainties in some intervals of temperature and 2) which of the two variants it provides data more reliable. (Author)

  20. Functional Status and Quality of Life in Survivors of Extracorporeal Membrane Oxygenation After the Norwood Operation.

    Science.gov (United States)

    Friedland-Little, Joshua M; Uzark, Karen; Yu, Sunkyung; Lowery, Ray; Aiyagari, Ranjit; Hirsch-Romano, Jennifer C

    2017-06-01

    Infants who require extracorporeal membrane oxygenation (ECMO) support after a Norwood operation are at increased risk for early and late death compared with patients who do not require ECMO post-Norwood. Little is known about the effect that ECMO post-Norwood has on functional status and quality of life among long-term survivors. We prospectively evaluated functional status and health-related quality of life in 12 surviving patients (cases) and 19 corresponding patients (controls) from a previous retrospective case-control assessment of long-term survival in patients requiring ECMO post-Norwood. Functional status was assessed with the Vineland Adaptive Behavior Scale-II, and health-related quality of life was assessed with the Pediatric Quality of Life Inventory (PedsQL) core and cardiac modules. There were no differences in demographics, extracardiac or genetic anomalies, or age at follow-up assessment between ECMO cases and non-ECMO controls. The Vineland Adaptive Behavior Scale-II scores were comparable between groups, with both groups demonstrating function in the normal range in all four domains tested. The only difference in PedsQL scores between cases and controls was perceived physical appearance, which was lower among ECMO survivors by both patient and proxy report. PedsQL scores of both groups were comparable to published scores for patients with single-ventricle congenital heart disease but generally lower than scores for the healthy population. The requirement for ECMO support after a Norwood operation does not appear to significantly affect functional status or quality of life among the subset of patients who achieve long-term survival. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  1. 75 FR 18545 - MMS Information Collection Activity: 1010-0067, Oil and Gas Well-Completion Operations, Extension...

    Science.gov (United States)

    2010-04-12

    ... Minerals Management Service MMS Information Collection Activity: 1010-0067, Oil and Gas Well- Completion.... ACTION: Notice of extension of an information collection (1010-0067). SUMMARY: To comply with the...; 381 Elden Street, MS-4024; Herndon, Virginia 20170-4817. Please reference ICR 1010-0067 in...

  2. High oxygen and high carbon dioxide modified atmospheres for shelf-life extension of minimally processed carrots

    NARCIS (Netherlands)

    Amanatidou, A.; Slump, R.A.; Gorris, L.G.M.; Smid, E.J.

    2000-01-01

    The impact of high O2 + high CO2 modified atmospheres (MA), on the preservation of minimally processed carrots was studied. A combination of 50% O2 + 30% CO2 prolonged the shelf life of sliced carrots compared to storage in air by 2 to 3 d. When the carrots received a pre-treatment with a 0.1%

  3. Qualification of Life Extension Schemes for Engine Components (Homologation des Programmes de Prolongation du cycle de vie des Organes Moteur)

    Science.gov (United States)

    1999-03-01

    gasses to permeate to the stabilised Zirconia . There are two main production surface of the substrate surface. Another process routes, air plasma spray and...in the paper illustrates that short term life © Crown Copyright 1998/DERA increases of up to 20% are sometimes at the price of less Published with

  4. High oxygen and high carbon dioxide modified atmospheres for shelf-life extension of minimally processed carrots

    NARCIS (Netherlands)

    Amanatidou, A.; Slump, R.A.; Gorris, L.G.M.; Smid, E.J.

    2000-01-01

    The impact of high O2 + high CO2 modified atmospheres (MA), on the preservation of minimally processed carrots was studied. A combination of 50% O2 + 30% CO2 prolonged the shelf life of sliced carrots compared to storage in air by 2 to 3 d. When the carrots received a pre-treatment with a 0.1% citri

  5. Vase Life Extension of Rose Cut Flowers (Rosa Hybirida as Influenced by Silver Nitrate and Sucrose Pulsing

    Directory of Open Access Journals (Sweden)

    Mohy E.N.E. Elgimabi

    2011-01-01

    Full Text Available Problem statement: This experiment was carried out in the laboratory of the Department of the Biology, Taif University, Saudi Arabia. Approach: The study was conducted to investigated the silver nitrate (AgNO3 and sucrose at different concentration on rose cut flowers longevity, which determined on the basis of wilting, chlorophyll retention and carbohydrate degradation .The treatments were, water control, 20, 30 or 50 ppm AgNO3 and sucrose at 1,2or 3% w/v. Results: The results showed, flower vase life was prolonged by all AgNO3 treatments. The best concentration was 30 ppm .The effect was further improved when AgNO3 was combined with 3% sucrose, which recorded the best vase life compared to other concentrations of sucrose .The per cent of wilting was minimized as result of using this combined treatment However the per cent of wilting increased with the increase in concentrations of AgNO3 and complete wilting occurred after 10, 8 and 7 days when treated with 20, 30 and 50 ppm of AgNO3, respectively, while sucrose shortened the period to reach wilting. Also AgNO3 at 30 ppm retarded the chlorophyll as well as carbohydrate degradation during the postharvest life. The experiments were repeated three times with three replicates and a completely randomized design had been used. The experiments extended from February, 2006-September, 2008. The difference between means was performed using Duncan multiple range test at 0.05 levels. Conclusion: A significant improvement in vase life of rose cut flowers was occurred when treated with 30 ppm (AgNO3 more effects when combined with 3% (w/v sucrose, so we recommended that to use the previous treatments with this concentrations for a long vase life and commercial productions.

  6. From bioterrorism exercise to real-life public health crisis: lessons for emergency hotline operations.

    Science.gov (United States)

    Uscher-Pines, Lori; Bookbinder, Sylvia H; Miro, Suzanne; Burke, Thomas

    2007-01-01

    Although public health agencies routinely operate hotlines to communicate key messages to the public, they are rarely evaluated to improve hotline management. Since its creation in 2003, the New Jersey Department of Health & Senior Services' Emergency Communications Center has confronted two large-scale incidents that have tested its capabilities in this area. The influenza vaccine shortage of 2004 and the April 2005 TOPOFF 3 full-scale bioterrorism exercise provided both real-life and simulated crisis situations from which to derive general insights into the strengths and weaknesses of hotline administration. This article identifies problems in the areas of staff and message management by analyzing call volume data and the qualitative observations of group feedback sessions and semistructured interviews with hotline staff. It also makes recommendations based on lessons learned to improve future hotline operations in public health emergencies.

  7. Refractory Metal Heat Pipe Life Test - Test Plan and Standard Operating Procedures

    Science.gov (United States)

    Martin, J. J.; Reid, R. S.

    2010-01-01

    Refractory metal heat pipes developed during this project shall be subjected to various operating conditions to evaluate life-limiting corrosion factors. To accomplish this objective, various parameters shall be investigated, including the effect of temperature and mass fluence on long-term corrosion rate. The test series will begin with a performance test of one module to evaluate its performance and to establish the temperature and power settings for the remaining modules. The performance test will be followed by round-the-clock testing of 16 heat pipes. All heat pipes shall be nondestructively inspected at 6-month intervals. At longer intervals, specific modules will be destructively evaluated. Both the nondestructive and destructive evaluations shall be coordinated with Los Alamos National Laboratory. During the processing, setup, and testing of the heat pipes, standard operating procedures shall be developed. Initial procedures are listed here and, as hardware is developed, will be updated, incorporating findings and lessons learned.

  8. OMNIITOX - operational life-cycle impact assessment models and information tools for practitioners

    DEFF Research Database (Denmark)

    Molander, S; Lidholm, Peter; Schowanek, Diederik

    2004-01-01

    of this case study-driven project are briefly presented and put in relation to the aims of contributing to an operational life cycle-impact assessment (LCIA) model for impacts of toxicants. The present situation has been characterised by methodological difficulties, both regarding choice......This article is the preamble to a set of articles describing initial results from an on-going European Commission funded, 5th Framework project called OMNIITOX, Operational Models aNd Information tools for Industrial applications of eco/TOXicological impact assessments. The different parts...... of the characterisation model(s) and limited input data on chemical properties, which often has resulted in the omission of toxicants from the LCIA, or at best focus on well characterised chemicals. The project addresses both problems and integrates models, as well as data, in an information system – the OMNIITOX IS...

  9. Life satisfaction in patients with and without spinal cord ischemia after advanced endovascular therapy for extensive aortic disease at mid-term follow-up.

    Science.gov (United States)

    Mehmedagic, Irma; Santén, Stefan; Jörgensen, Sophie; Acosta, Stefan

    2016-11-11

    Advanced endovascular aortic repair can be used to treat patients with extensive and complex aortic disease who are at risk of spinal cord ischaemia. The aim of this study was to compare whether life satisfaction differs between patients with and without spinal cord ischaemia at mid-term follow-up. Nested case-control study. Among patients undergoing advanced endovascular aortic repair between 2009 and 2012, 18 patients with spinal cord ischaemia and 33 without were interviewed at home. The Life Satisfaction Questionnaire (LiSat-11) and the Satisfaction With Life Scale (SWLS) were used. LiSat-11 found that patients with spinal cord ischaemia were more dissatisfied with their activities of daily living than were patients without spinal cord ischaemia (p=0.012). Both groups had similar, very low, scores in the sexual life domain; median 2.0 (interquartile range (IQR) 1.5-3.0) and 3.0 (IQR 2.0-4.0), respectively. There was no difference in SWLS between the groups. This study cohort of patients who underwent advanced endovascular aortic repair was rather homo-genous in their rating of life satisfaction and there was little difference between mid-term survivors who had spinal cord ischaemia and those who did not.

  10. Generation of life events in bipolar spectrum disorders: a re-examination and extension of the stress generation theory.

    Science.gov (United States)

    Bender, Rachel E; Alloy, Lauren B; Sylvia, Louisa G; Urosevic, Snezana; Abramson, Lyn Y

    2010-09-01

    The extent to which stress generation occurs in bipolar spectrum disorders (BSD) is not well understood. The present study examined whether 75 BSD participants experienced elevated rates of behavior-dependent life events, as compared with 38 normal control participants. Within the BSD group, we also examined whether depressive or hypomanic symptoms prospectively predicted increases in various types of negative and positive life events. Results indicated that BSD participants experienced overall increases in behavior-dependent events over the follow-up, as compared with normal controls. At the symptom level, the event generation process occurred in more specific event domains. Results suggest that the stress generation theory of unipolar depression can be extended to BSD and that the type of generated events may be polarity-specific.

  11. Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.

    Science.gov (United States)

    Mouchiroud, Laurent; Molin, Laurent; Dallière, Nicolas; Solari, Florence

    2010-01-01

    Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age.

  12. Combined effects of thermosonication and slightly acidic electrolyzed water on the microbial quality and shelf life extension of fresh-cut kale during refrigeration storage.

    Science.gov (United States)

    Mansur, Ahmad Rois; Oh, Deog-Hwan

    2015-10-01

    This study evaluated the efficacy of thermosonication combined with slightly acidic electrolyzed water (SAcEW) on the shelf life extension of fresh-cut kale during storage at 4 and 7 °C. Each kale (10 ± 0.2 g) was inoculated to contain approximately 6 log CFU/g of Listeria monocytogenes. Each inoculated or uninoculated samples was dip treated at 40 °C for 3 min with deionized water, thermosonication (400 W/L), SAcEW (5 mg/L), sodium chlorite (SC; 100 mg/L), sodium hypochlorite (SH; 100 mg/L), and thermosonication combined with SAcEW, SC, and SH (TS + SAcEW, TS + SC, and TS + SH, respectively). Growths of L. monocytogenes and spoilage microorganisms and changes in sensory (overall visual quality, browning, and off-odour) were evaluated. The results show that lag time and specific growth rate of each microorganism were not significantly (P > 0.05) affected by treatment and storage temperature. Exceeding the unacceptable counts of spoilage microorganisms did not always result in adverse effects on sensory attributes. This study suggests that TS + SAcEW was the most effective method to prolong the shelf life of kale with an extension of around 4 and 6 days at 4 and 7 °C, respectively, and seems to be a promising method for the shelf life extension of fresh produce.

  13. An Extensive comparison of operating-lease capitalisation approaches and their unavoidable assumptions : Are further disclosures desirable?

    NARCIS (Netherlands)

    Lückerath – Rovers, M.; Bos, de A.

    2009-01-01

    Previous research of Imhoff, Lipe and Wright (1991), Beattie, Edwards and Goodacre (1998) and others has shown that the capitalisation of operating leases on the balance sheet has a major impact on the accounting ratios. This empirical study expands previous research on two issues. First, we refine

  14. An Extensive comparison of operating-lease capitalisation approaches and their unavoidable assumptions : Are further disclosures desirable?

    NARCIS (Netherlands)

    Lückerath – Rovers, M.; Bos, de A.

    2009-01-01

    Previous research of Imhoff, Lipe and Wright (1991), Beattie, Edwards and Goodacre (1998) and others has shown that the capitalisation of operating leases on the balance sheet has a major impact on the accounting ratios. This empirical study expands previous research on two issues. First, we refine

  15. Non-oxidative dehydroaromatization of methane:an effective reaction regeneration cyclic operation for catalyst life extension

    OpenAIRE

    Portilla Ovejero, Mª Teresa; LLOPIS ALONSO, FRANCISCO; LLOPIS ALONSO, FRANCISCO JAVIER; Martínez, Cristina

    2015-01-01

    Non-oxidative methane aromatization is an attractive direct route for producing higher hydrocarbons. It is highly selective to benzene despite the low conversion due to thermodynamic limitations, and Mo/H-ZSM-5, the first catalyst proposed for this reaction, is still considered as one of the most adequate. The major problem of this process is the severe catalyst deactivation due to the rapid build-up of carbonaceous deposits on the catalysts. Here we present an effective regeneration procedur...

  16. A new tool for life cycle inventories of agricultural machinery operations

    Directory of Open Access Journals (Sweden)

    Daniela Lovarelli

    2016-03-01

    Full Text Available The interest in environmental assessments about agricultural processes is fast growing and asking for new tools for accurate impact evaluations. The methodology commonly used to go through these studies is the life cycle assessment, of which the inventory phase (life cycle inventory, LCI is an essential step. For studies focusing on agricultural productions, the completion of LCI is particularly complex: taking into account the pedo-climatic and mechanical operative variability is evidently difficult. However, the prediction of the environmental impact of mechanical operations caused by the agricultural sector is essential to quantify the impact categories for which it is responsible. A new tool, ENVIAM, was developed to complete LCI to guarantee the availability of local data that describe the mechanical and pedo-climatic conditions occurring in the Po Valley area and widely applicable as well. It calculates mechanical power requests, directly consumed inputs (i.e., fuel, lubricant and material consumption of a productive system by taking into account soil texture, specific machinery operations and coupling solutions as defined by the user. A subdivision of working time and defined engine load have been considered to calculate fuel consumption; with regard to outputs, exhaust gases emissions from internal combustion engines have been assessed by evaluating the emissive stages of belonging as stated by the EU Directive. A case study was also performed to highlight the differences that occur when an analysis is fulfilled in a context with features different from the average, and resulted in significant variations for the inventory. In more details, a comparison was carried out both with Ecoinvent database and within ENVIAM. With regard to fuel consumption, by changing the soil texture, the analysis showed a range between 64%-184% for sandy and clay soils, respectively, if compared with medium texture ones. With this tool, local contexts defined

  17. Development of a model to compute the extension of life supporting zones for Earth-like exoplanets.

    Science.gov (United States)

    Neubauer, David; Vrtala, Aron; Leitner, Johannes J; Firneis, Maria G; Hitzenberger, Regina

    2011-12-01

    A radiative convective model to calculate the width and the location of the life supporting zone (LSZ) for different, alternative solvents (i.e. other than water) is presented. This model can be applied to the atmospheres of the terrestrial planets in the solar system as well as (hypothetical, Earth-like) terrestrial exoplanets. Cloud droplet formation and growth are investigated using a cloud parcel model. Clouds can be incorporated into the radiative transfer calculations. Test runs for Earth, Mars and Titan show a good agreement of model results with observations.

  18. Extension of gas utilization operation time in case of decreasing methane concentration; Verlaengerung der Betriebsdauer von Gasverwertungsanlagen bei fallenden Methankonzentrationen

    Energy Technology Data Exchange (ETDEWEB)

    Hegemann, Tim [DMT GmbH und Co. KG, Essen (Germany); Brandt, Andreas [Steag GmbH, Essen (Germany). Bereich Grubengas NRW; Minegas GmbH, Essen (Germany)

    2013-06-15

    In the Ruhr area Minegas GmbH (Minegas) currently operates gas engines on abandoned mine methane at round about 17 different locations. In the course of time the methane content decreases at some production sites, while in unison the carbon dioxide content increases. Whereas the composition of abandoned mine methane and landfill gas are slightly different, the worsening of the quality is comparable, making it harder to operate the gas engines or even prevent them from running. The minimum methane concentration in the gas-mixture needed for the combustion in the gas engines can theoretically be lowered by adding pure oxygen to the gas mixture. That way, depending on the production site and the future development, the utilization of methane can be extended for years - while using the existing gas engines and technologies. (orig.)

  19. Extension of the shelf life of prawns (Penaeus japonicus) by vacuum packaging and high-pressure treatment.

    Science.gov (United States)

    López-Caballero, M E; Pérez-Mateos, M; Borderías, J A; Montero, P

    2000-10-01

    The present study has investigated the application of high pressures (200 and 400 MPa) in chilled prawn tails, both conventionally stored (air) and vacuum packaged. Vacuum packaging and high-pressure treatment did extend the shelf life of the prawn samples, although it did affect muscle color very slightly, giving it a whiter appearance. The viable shelf life of 1 week for the air-stored samples was extended to 21 days in the vacuum-packed samples, 28 days in the samples treated at 200 MPa, and 35 days in the samples pressurized at 400 MPa. Vacuum packaging checked the onset of blackening, whereas high-pressure treatment aggravated the problem. From a microbiological point of view, batches conventionally stored reached about 6 log CFU/g or even higher at 14 days. Similar figures were reached in total number of bacteria in vacuum-packed samples and in pressurized at 200-MPa samples at 21 days. When samples were pressurized at 400 MPa, total numbers of bacteria were below 5.5 log CFU/g at 35 days of storage. Consequently, a combination of vacuum packaging and high-pressure treatment would appear to be beneficial in prolonging freshness and preventing spotting.

  20. Defectivity and particle reduction for mask life extension, and imprint mask replication for high-volume semiconductor manufacturing

    Science.gov (United States)

    Emoto, Keiji; Sakai, Fumio; Sato, Chiaki; Takabayashi, Yukio; Nakano, Hitoshi; Takabayashi, Tsuneo; Yamamoto, Kiyohito; Hattori, Tadashi; Hiura, Mitsuru; Ando, Toshiaki; Kawanobe, Yoshio; Azuma, Hisanobu; Iwanaga, Takehiko; Choi, Jin; Aghili, Ali; Jones, Chris; Irving, J. W.; Fletcher, Brian; Ye, Zhengmao

    2016-03-01

    Imprint lithography has been shown to be an effective technique for replication of nano-scale features. Jet and Flash* Imprint Lithography (J-FIL*) involves the field-by-field deposition and exposure of a low viscosity resist deposited by jetting technology onto the substrate. The patterned mask is lowered into the fluid which then quickly flows into the relief patterns in the mask by capillary action. Following this filling step, the resist is crosslinked under UV radiation, and then the mask is removed, leaving a patterned resist on the substrate. Criteria specific to any lithographic process for the semiconductor industry include overlay, throughput and defectivity. The purpose of this paper is to describe the technology advancements made in the reduction of particle adders in an imprint tool and introduce the new mask replication tool that will enable the fabrication of replica masks with added residual image placement errors suitable for memory devices with half pitches smaller than 15nm. Hard particles on a wafer or mask create the possibility of creating a permanent defect on the mask that can impact device yield and mask life. By using material methods to reduce particle shedding and by introducing an air curtain system, test stand results demonstrate the potential for extending mask life to better than 1000 wafers. Additionally, a new replication tool, the FPA-1100 NR2 is introduced. Mask chuck flatness simulation results were also performed and demonstrate that residual image placement errors can be reduced to as little as 1nm.

  1. The Effects of Life Domains, Constraints, and Motivations on Academic Dishonesty: A Partial Test and Extension of Agnew's General Theory.

    Science.gov (United States)

    Cochran, John K

    2017-08-01

    Recently, Robert Agnew introduced a new general theory of crime and delinquency in which he attempted to corral the vast array of theoretical "causes" of criminal conduct into a more parsimonious statement organized into one of five life domains: self, family, peers, school, and work as well as constraints against crime and motivation for it. These domains are depicted as the source of constraints and motivations and whose effects are, in part, mediated by these constraints and motivations. Based on self-report data on academic dishonesty from a sample of college students, the present study attempts to test this general theory. While several of the life domain variables had significant effects of cheating in the baseline model, all of these effects were fully mediated by constraints and motivations. In the final model, academic dishonesty was observed to be most significantly affected by the perceived severity of formal sanction threats, the number of credit hours enrolled, the frequency of skipping classes, and pressure from friends.

  2. Evaluation of the integrity and duration of the Laguna Verde nuclear power plant life- Plant Life Management program (PLIM). TC MEX 04/53 Technical Cooperation Project; Evaluacion de la integridad y extension de vida de la planta de potencia nuclear Laguna Verde- Programa de manejo de vida de planta (PLIM). Proyecto de cooperacion tecnica TC MEX 04/53

    Energy Technology Data Exchange (ETDEWEB)

    Arganis J, C.R.; Diaz S, A.; Aguilar T, J.A. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2006-07-01

    As part of the IAEA TC MEX 04/53 Project 'Evaluation of the integrity and extension of life of the Laguna Verde nuclear power plant Handling Program of plant' whose objective is the one of beginning the actions to apply the methodology of Handling of plant life in the Unit 1 of the Laguna Verde Nucleo electric Central for to obtain the Renovation of License in 2020 the ININ, through the Department of Synthesis and Characterization of materials has carried out more of 20 analysis of susceptibility to the intergranular cracking for corrosion under effort in interns so much of the reactor of the unit 1 like of the unit 2 documenting the current state of components based on the type or types of materials that conform them, to it thermomechanical history, operational and of production, as well as of the particularities associated to its use and operation. For the application of the methodology of life handling of plant 5 structure systems or pilot components were selected, to carry out the programs of handling of the aging and handling of plant life: The encircling of the reactor core (Core Shroud), the reactor pressure vessel (Reactor Pressure Vessel), the primary container (Primary Containment), the recirculation system of feeding water (Reactor Feed Water) and cables. (Author)

  3. Operational energy in the life cycle of residential dwellings: The experience of Spain and Colombia

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, Oscar [University of Rovira i Virgili, Environmental and Analysis Management Group (AGA), Department of Chemical Engineering, Av. Paisos Catalanes 26, 43007 Tarragona (Spain); University of Pamplona, Department of Industrial Engineering, Km 1 Via Bucaramanga, Pamplona, N de S (Colombia); Castells, Francesc [University of Pamplona, Department of Industrial Engineering, Km 1 Via Bucaramanga, Pamplona, N de S (Colombia); Sonnemann, Guido [University of Rovira i Virgili, Visiting Senior Research Fellow, AGA Group (AGA) (Spain)

    2010-02-15

    Life Cycle Assessment (LCA) has been applied within the residential building sector of two buildings, one in each a developed (Spain) and a developing (Colombia) country. The main goal of this paper involves the environmental loads and also brings together the operational energy for activities during the operation phase such as HVAC, domestic hot water, electrical appliances, cooking and illumination. The present research compares two real scenarios: Situation 1, where 100% of the dwelling's energy is supplied with electricity only and Situation 2, where dwellings can be operated with natural gas plus electricity. The results for the environmental impacts using natural gas plus electricity show that of the Spanish environmental impacts air conditioning had the highest impact with approximately 27-42% due to the electricity used to power it. In Colombian results showed that electrical appliances had the highest environmental impacts in the same order of magnitude with approximately 60% and cooking had the best reduction of emissions due to the use of natural gas, from 10% down to less than 2%. The origin of the energy source used in each Country plays an important role to minimize environmental impacts, as was demonstrated by the environmental impacts of its use in Colombia where 78% of the electricity came from hydroelectric plants whereas in Spain it is more mixed, fossil fuels represented 55%, nuclear 18% and wind 9%. In summary, LCA has been applied because this methodology supports the decision making to concern environmental sustainability. (author)

  4. Los Alamos National Laboratory Request for Proposals: Trident Laser System (TLS) Redeployment and Life Extension, October 5, 2016

    Energy Technology Data Exchange (ETDEWEB)

    Stringer, Steven F. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-04

    In May 2016, LANS announced that the Trident Laser Facility would cease operating effective September 15, 2016. That date was subsequently extended. The current plan is to operate for an additional, limited period in early CY 2017, and to leverage that activity to provide a training opportunity to the party that will redeploy the TLS. The TLS will then be disassembled and packaged for shipping to the new site, where it may be reconstituted and continue to be used by the physics research community. It is LANS’ intent that Trident will be sited with an organization that will supply its own funding for TLS installation, calibration, and lifecycle operation. Ideally, the receiving party will plan to upgrade TLS with new capability. The equipment to be transferred includes the laser, its power supply, target station and chamber, and a suite of diagnostic instrumentation. Under a Joint Use Agreement it is anticipated that all equipment will remain property of the Laboratory and subject to on-site configuration verification.

  5. Optimisation of battery operating life considering software tasks and their timing behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Lipskoch, Henrik

    2010-02-19

    Users of mobile embedded systems have an interest in long battery operating life. The longer a system can operate without need for recharge or battery replacement, the more will maintenance cost and the number of faults due to insufficient power supply decrease. Operating life is prolonged by saving energy, which may reduce available processing time. Mobile embedded systems communicating with other participants like other mobiles or radio stations are subject to time guarantees ensuring reliable communication. Thus, methods that save energy by reducing processing time are not only subject to available processing time but subject to the embedded system's time guarantees. To perform parameter optimisations offline, decisions can be taken early at design time, avoiding further computations at run-time. Especially, to compute processor shutdown durations offline, no extra circuitry to monitor system behaviour and to wake up the processor needs to be designed, deployed, or power supplied: only a timer is required. In this work, software tasks are considered sharing one processor. The scheduling algorithm earliest deadline first is assumed, and per-task, a relative deadline is assumed. Tasks may be instantiated arbitrarily as long as this occurrence behaviour is given in the notion of event streams. Scaling of the processor's voltage and processor shutdown are taken into account as methods for saving energy. With given per task worst-case execution times and the tasks' event streams, the real-time feasibility of the energy optimised solutions is proven. The decision which energy saving solution provides longest operating life is made with the help of a battery model. The used real-time feasibility test has the advantage that it can be approximated: this yields an adjustable number of linear optimisation constraints. Reducing the processor's voltage reduces processor frequency, therefore, execution times increase. The resulting slowdown becomes the

  6. Drug discovery using very large numbers of patents. General strategy with extensive use of match and edit operations

    Science.gov (United States)

    Robson, Barry; Li, Jin; Dettinger, Richard; Peters, Amanda; Boyer, Stephen K.

    2011-05-01

    A patent data base of 6.7 million compounds generated by a very high performance computer (Blue Gene) requires new techniques for exploitation when extensive use of chemical similarity is involved. Such exploitation includes the taxonomic classification of chemical themes, and data mining to assess mutual information between themes and companies. Importantly, we also launch candidates that evolve by "natural selection" as failure of partial match against the patent data base and their ability to bind to the protein target appropriately, by simulation on Blue Gene. An unusual feature of our method is that algorithms and workflows rely on dynamic interaction between match-and-edit instructions, which in practice are regular expressions. Similarity testing by these uses SMILES strings and, less frequently, graph or connectivity representations. Examining how this performs in high throughput, we note that chemical similarity and novelty are human concepts that largely have meaning by utility in specific contexts. For some purposes, mutual information involving chemical themes might be a better concept.

  7. Effect of quince seed mucilage edible films incorporated with oregano or thyme essential oil on shelf life extension of refrigerated rainbow trout fillets.

    Science.gov (United States)

    Jouki, Mohammad; Yazdi, Farideh Tabatabaei; Mortazavi, Seyed Ali; Koocheki, Arash; Khazaei, Naimeh

    2014-03-17

    The effects of quince seed mucilage film (QSMF) containing oregano (O) or thyme (T) essential oil on shelf life extension of rainbow trout (Oncorhynchus mykiss) fillets during refrigerated storage (4°C) were evaluated over a period of 18days. Films were prepared in four different concentrations of essential oils, including 0, 1, 1.5 and 2%. The control and the wrapped fillet samples were analyzed periodically for microbiological (aerobic and psychrotrophic count, Pseudomonas spp., H2S-producing bacteria, lactic acid bacteria, and Enterobacteriaceae), chemical (TBA, TVB-N, TMA-N), and sensory characteristics. Bacteria grew most quickly in trout fillets stored in air, followed by those wrapped with QSMF and the lowest counts were in wrapped samples with QSMF+2%T. Pseudomonas spp., Enterobacteriaceae and LAB counts were significantly lower in samples wrapped with QSMF+2%T. The lowest TBA value was obtained in fillets wrapped QSMF containing 2% oregano essential oil. The strong antioxidant activity of QSMF+2%O was related to the composition of oregano essential oil. The GC analysis of essential oil components revealed that carvacrol (81.85%) was the major component of oregano essential oil. TBA value varied for all treatments and remained lower than 2mg MDA/kg throughout storage. The formation of TVB-N, TMA-N increased with time of storage. TVB-N and TMA-N correlated well with the microbiological data, indicating that along with TVB-N, TMA-N may serve as a useful index for fillets spoilage. QSMF extended the microbial shelf life of rainbow trout fillets by 2days, whereas the QSMF+1%O, QSMF+1.5%O, QSMF+2%O, QSMF+1%T, QSMF+1.5%T and QSMF+2%T resulted in a significant shelf life extension of the trout fillets by 3, 5, 9, 6, 10 and 11days, respectively, as compared to the control samples.

  8. Wind Turbine Blade Life-Time Assessment Model for Preventive Planning of Operation and Maintenance

    Directory of Open Access Journals (Sweden)

    Mihai Florian

    2015-09-01

    Full Text Available Out of the total wind turbine failure events, blade damage accounts for a substantial part, with some studies estimating it at around 23%. Current operation and maintenance (O&M practices typically make use of corrective type maintenance as the basic approach, implying high costs for repair and replacement activities as well as large revenue losses, mainly in the case of offshore wind farms. The recent development and evolution of condition monitoring techniques, as well as the fact that an increasing number of installed turbines are equipped with online monitoring systems, offers a large amount of information on the blades structural health to the decision maker. Further, inspections of the blades are often performed in connection with service. In light of the obtained information, a preventive type of maintenance becomes feasible, with the potential of predicting the blades remaining life to support O&M decisions for avoiding major failure events. The present paper presents a fracture mechanics based model for estimating the remaining life of a wind turbine blade, focusing on the crack propagation in the blades adhesive joints. A generic crack propagation model is built in Matlab based on a Paris law approach. The model is used within a risk-based maintenance decision framework to optimize maintenance planning for the blades lifetime.

  9. Long-term health-related quality of life improvements among patients treated with lurasidone: results from the open-label extension of a switch trial in schizophrenia.

    Science.gov (United States)

    Awad, George; Ng-Mak, Daisy; Rajagopalan, Krithika; Hsu, Jay; Pikalov, Andrei; Loebel, Antony

    2016-06-01

    Long-term improvement of health-related quality of life (HRQoL) in schizophrenia may improve adherence and reduce relapse and rehospitalization. This analysis examines long-term changes in HRQoL among patients with schizophrenia switched to lurasidone from other antipsychotics. Patients who completed an open-label 6-week switch study continued on lurasidone for an additional 24-weeks. HRQoL was measured using the self-reported Personal Evaluation of Transitions in Treatment (PETiT) scale and Short-Form 12 (SF-12) questionnaire. The PETiT assessed HRQoL via total and domain scores (adherence-related attitude and psychosocial functioning). The SF-12 assessed patients' mental and physical component summary scores (MCS and PCS). Mean changes from the initial baseline were calculated at extension baseline and extension endpoint using analysis of covariance models. Analyses were further stratified by prior antipsychotic medication and responder status; responders were defined as having a ≥20 % improvement in Positive and Negative Syndrome Scale during the first 6-weeks of treatment. The analysis included 144 patients with PETIT or SF-12 data who received ≥1 dose of lurasidone. Mean (standard deviation) PETiT total score improved significantly from 34.9 (9.3) at baseline to 39.5 (8.9) at extension baseline and 39.1 (9.0) at extension endpoint, representing improvements of 4.5 (7.9) and 5.1 (7.2) points, respectively (both p schizophrenia experienced HRQoL improvements that were sustained for an additional 24 weeks of treatment. Further study is warranted to understand the implications of these improvements in terms of employment, adherence, relapse, and rehospitalization. Clinical trials.gov identifier NCT01143090 (June 10th, 2010).

  10. Shelf life extension and antioxidant activity of 'Hayward' kiwi fruit as a result of prestorage conditioning and 1-methylcyclopropene treatment.

    Science.gov (United States)

    Park, Yong Seo; Im, Myeng He; Gorinstein, Shela

    2015-05-01

    Kiwi fruits (Actinidia deliciosa C.F. Liang et A.R. Ferguson) were treated by prestorage conditioning (20 °C for 2 days), 1-methylcyclopropene (1-MCP, 1 ppm for 16 h) and conditioning plus 1-MCP. After the treatment the fruits were immediately stored at 0 °C during 24 weeks. Flesh firmness gradually decreased with storage time and the rate of its loss was lower in 1-MCP and conditioning plus 1-MCP treatments than those of control or conditioning. However, SSC, acidity and pH did not change among treatments. Starch content decreased during the storage time regardless of treatments. Oppositely the amount of reducing sugars increased at the same duration of the treatments. Rate and incidence of fruit decay was the lowest in fruit treated with conditioning plus 1-MCP treatment. Fruit decay mainly caused pathogen Botrytis cinerea and its rate significantly decreased with conditioning plus 1-MCP treatment. Ethylene and respiration abruptly increased after 8 weeks of storage, but their contents were lower in 1-MCP and conditioning plus 1-MCP. Total soluble phenolics, flavonoids, and total antioxidant capacities were much higher than in other treatments. Kiwi fruits treated with conditioning plus 1-MCP extended the shelf life by reducing the rate of fruit decay and softening during the storage. The bioactive compounds and total antioxidant status of fruits increased during the treatment.

  11. Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans.

    Science.gov (United States)

    Asthana, Jyotsna; Yadav, Deepti; Pant, Aakanksha; Yadav, A K; Gupta, M M; Pandey, Rakesh

    2016-09-01

    The advancements in the field of gerontology have unraveled the signaling pathways that regulate life span, suggesting that it might be feasible to modulate aging. To this end, we isolated a novel phytomolecule Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside (ARX) from Premna integrifolia and evaluated its antiaging effects in Caenorhabditis elegans The spectral data analysis revealed the occurrence of a new compound ARX. Out of the three tested pharmacological doses of ARX, viz. 5, 25, and 50 µM, the 25-µM dose was able to extend life span in C. elegans by more than 39%. The present study suggests that ARX affects bacterial metabolism, which in turn leads to dietary restriction (DR)-like effects in the worms. The effect of ARX on worms with mutations (mev-1, eat-2, sir-2.1, skn-1, daf-16, and hsf-1) indicates that ARX-mediated life-span extension involves mechanisms associated with DR and maintenance of cellular redox homeostasis. This study is the first time report on longevity-promoting activity of ARX in C. elegans mediated by stress and DR-regulating genes. This novel phytomolecule can contribute in designing therapeutics for managing aging and age-related diseases.

  12. An Extension to the Owa-Srivastava Fractional Operator with Applications to Parabolic Starlike and Uniformly Convex Functions

    Directory of Open Access Journals (Sweden)

    Oqlah Al-Refai

    2009-01-01

    Full Text Available Let 𝒜 be the class of analytic functions in the open unit disk . We define Θα,β:𝒜→𝒜 by (Θα,βf(z:=Γ(2−αzαDzα(Γ(2−βzβDzβf(z,(α,β≠2,3,4…, where Dzγf is the fractional derivative of f of order γ. If α,β∈[0,1], then a function f in 𝒜 is said to be in the class SPα,β if Θα,βf is a parabolic starlike function. In this paper, several properties and characteristics of the class SPα,β are investigated. These include subordination, characterization and inclusions, growth theorems, distortion theorems, and class-preserving operators. Furthermore, sandwich theorem related to the fractional derivative is proved.

  13. The extension of shelf-life of chicken meat after application of caraway and anise essential oils and vacuum packaging

    Directory of Open Access Journals (Sweden)

    Maciej Kluz

    2016-01-01

    Full Text Available Normal 0 21 false false false SK X-NONE X-NONE The effect of caraway (CEO and anise (AEO essential oils as well as vacuum packaging (VP in extending of the shelf life of fresh chicken breast meat stored at 4 °C was investigated. CEO and AEO were used at concentrations 0.2% v/w with and without VP. Microbiological properties of chicken breast meat were monitored over a 16 day period. The microbiological parameters as the anaerobic plate count (AC, Enterobacteraceae, lactic acid bacteria and Pseudomonas spp. counts were detected. The anaerobic plate counts ranged from 2.77 log cfu.g-1 in all tested group on 0 day to 5.45 log cfu.g-1 on 16 day in control group stored in air condition. The number of lactic acid bacteria ranged from 3.20 log cfu.g-1 in all tested group on 0 day to 4.75 log cfu.g-1 on 16 day in control group stored in air condition. Enterobacteriaceae counts ranged from 0.00 to 4.25 log cfu.g-1 on 16 day in control group stored in air condition. The number of Pseudomonas spp. ranged from 0.00 log cfu.g-1 in all tested group on 0 day to 2.65 log cfu.g-1 on 16 day in control group stored in air condition. Statistically significant differences (P≤0.001 were found among tested group in all tested microorganisms. Among the antimicrobial combination treatments were examined in the study, the as application of vacuum packaging, EDTA, and essential oils were the most effective against the growth of lactic acid bacteria and Enterobactericeae and to a less extent on anaerobic plate count. The results of this present study suggest the possibility of using the essential oil of caraway and anise as natural food preservatives and potential source of antimicrobial ingredients for chicken breast meat.

  14. Useful life extension of steam turbine rotors; Alargamiento de la vida en rotores de turbina de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Arelle, Carlos [Turbomaquinas S. A. de C.V., La Piedad, Michoacan (Mexico)

    2007-11-15

    The continuous use of steam turbines, the chemistry of the steam itself and the variations of operation velocities, cause the gradual deterioration by erosion, oxidation and/or corrosion of the rotors and blades. When this happens most of the original manufacturers recommend to rectify the areas, diminishing the surfaces, or to compare with a new rotor. TURBOMAQUINARIAS S.A. de C.V. has developed the most reliable and safe methods to return the rotor to its original dimensions and in case of recurrent problems such as erosion, oxidation and/or wear, it offers the alternative of attaching coatings metallurgically compatible with which these problems are eliminated or diminished that might show up on the rotor surface as well as in the body of the discs or of the blades. These restoring methods are recommended by the international standards such as API 687. [Spanish] El uso continuo de las turbinas de vapor, la quimica del mismo vapor y la variacion de las velocidades de operacion, ocasionan el deterioro gradual por erosion, oxidacion y/o corrosion de los rotores y de los alabes. Al ocurrir esto la mayoria de los fabricantes originales recomiendan rectificar las areas, disminuyendo las superficies, o bien comparar un rotor nuevo. TURBOMAQUINARIAS S.A. de C.V. ha desarrollado los metodos mas confiables y seguros para devolver a su rotor las dimensiones originales y en caso de problemas recurrentes tales como erosion, oxidacion y/o desgaste, ofrece la alternativa de agregar recubrimientos metalurgicamente compatibles con los cuales se eliminan o se disminuyen estos problemas que pueden presentarse tanto en la superficie del rotor como del cuerpo de los discos o bien de los alabes. Estos metodos de restauracion son recomendados por las normas internacionales tales como la API 687.

  15. DETERMINATION OF MAIN OUTPUT PARAMETERS FOR HYDROFICATED CONSTRUCTION AND ROAD-BUILDING MACHINES AT OPERATIONAL STAGE OF THEIR LIFE CYCLE

    Directory of Open Access Journals (Sweden)

    A. N. Maximenko

    2014-01-01

    Full Text Available Usage efficiency of mechanical engineering products is determined by level of their operating capability. Expenses connected with provision of operating capability for the whole operational period exceed initial cost of the products by 6-10-fold. Moreover , while being used the expenses have a tendency to increase with reduction of output parameters that ensure product application efficiency for its intended purpose. It is necessary to take into account these changes at manufacturing stages of mechanical engineering products. Maximum efficiency can be obtained at the operational stage of the product life cycle only as a result of complex and interrelated measures during designing, manufacturing and usage of the specific product for its intended purpose with due account of its output parameter dynamics. While using the product an analysis of its output parameter dynamics will make it possible to determine maximum value of the operating capability, operational expenses and best practices for obtaining maximum profit per operating time unit.Taking hydroficated excavators of the 5th grade as an example the paper presents dynamics of main output parameters at the operational stage of their life cycle; reveals the main factor influencing on intensity of hydroficated machine operating capability reduction; substantiates an expediency of taking into account output parameter dynamics while evaluating efficiency of its usage; proposes a methodology for determination of or a pay-off time period for recoupment of expenses pertaining to machine procurement and optimum time period for operational stage, its life cycle that corresponds to obtaining maximum profit.Nowadays constant values of main output parameters (operating capability, self cost of machine-hour corresponding to the beginning of operation are to be taken into account while determining expediency of machine creation. Practically they significantly change in the process of machine operation this

  16. Study of the state of the art of the technologies for the extension of the useful life of the gas turbine buckets; Estudio del estado del arte de las tecnologias de extension de la vida util de los alabes de turbina de gas

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Gutierrez, Ramiro Arturo

    1995-10-01

    In the present work a revision of the state of the art of the technologies involved in the extension of useful life of the buckets of a gas turbine is made. Among the subjects that are presented, stand out the following ones: materials for the manufacture of blades; processes of blade manufacturing; Wearing down of blades after a prolonged service; evaluation methods for blades; Limits of repair for blades rehabilitated by welding and strong welding; cleaning of blades; recovery heat treatments; Isostatic compression in hot; Welding of blades; electrical laser beam machining; coating for blades; shotpeening of the blades; balance of blades. In addition as a contribution of the present work, the development of a flow chart for the repair of buckets of gas turbines that exhibit the following typical wearing downs: corrosion, oxidation, erosion, frictions, impact and thermofluency. It is also included as a contribution, a proposal of rehabilitation for the extension of the useful life of the first stage blades of the 3 gas turbines Asea Brown Boveri (ABB) model 11 D-5 MCA, 61.2 MW that operate in the combined cycle thermoelectric power station El Sauz located in the state of Queretaro, Mexico. [Espanol] En el presente trabajo se realiza una revision del estado del arte de las tecnologias involucradas en la extension de vida util de los alabes de turbina de gas. Entre los temas que se presentan destacan los siguientes: materiales para la fabricacion de alabes; procesos de fabricacion de alabes; desgaste en alabes despues de un servicio prolongado; Metodos de evaluacion para alabes; limites de reparacion para alabes rehabilitados por soldadura y soldadura fuerte; limpieza de alabes; tratamientos termicos de recuperacion; Compresion isostatica en caliente; soldadura de alabes; maquinados electricos y con rayo laser; Recubrimientos para alabes; granallado de alabes; balance de alabes. Ademas se presenta como aportacion del presente trabajo, el desarrollo de un diagrama de

  17. EFFECTIVENESS OF PHYSIOTHERAPY MANAGEMENT OVER QUALITY OF LIFE IN POST OPERATIVE GYNAECOLOGICAL PATIENTS

    Directory of Open Access Journals (Sweden)

    Ponmathi .P

    2016-10-01

    Full Text Available Background: Gynaecological surgeries refer to surgery on the female reproductive system. Woman may undergo a Gynaecological surgery for different reasons, including; Uterine prolapse, Cancer of the uterus, cervix, or ovaries, Endometriosis, Bleeding, Adenomyosis etc.Gynaecological surgeries includes procedures such as hysterectomy, oopherectomy, salphingectomy, myomectomy, ovarin cystectomy, etc. The Physiotherapy referral is essential in such cases but most of time the patients are not referred for Physiotherapy. Hence the current study was undertaken. Thus the objective is to find out the Effectiveness of Physiotherapy management over quality of life in post-operative Gynaecological patients. Methods: 32 females who underwent Gynecological surgery were taken into the study and divided conveniently into Group A and Group B consisting of 16 females each. Physiotherapy intervention given to Group A includes- Breathing exercises, Coughing techniques, Circulatory exercises, Knee rolling, log rolling, patient made to sit, Abdominal exercises, Pelvic tilting, Getting in and out of the bed, Pelvic floor exercises and mobilization inside the ward, outside the ward and stair climbing where as conventional treatment which includes Breathing exercises and Back care were given to Group B for a period of 5 days. Outcome measures used were VAS (Visual Analog Scale and ASIS (Abdominal Surgery Impact Scale. Results: There was a significant difference in post test score of VAS (p=0.0001 and ASIS (p=0.0001 in Group A as compared to Group B. Conclusion: This study revealed that physiotherapy intervention performed immediately after Gynecological surgery improves quality of life of the patients and a scheduled exercise program benefits the patient more than conventional Physiotherapy management and it should be emphasized to all the post Gynecological surgery Patients.

  18. Optimisation of battery operating life considering software tasks and their timing behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Lipskoch, Henrik

    2010-02-19

    Users of mobile embedded systems have an interest in long battery operating life. The longer a system can operate without need for recharge or battery replacement, the more will maintenance cost and the number of faults due to insufficient power supply decrease. Operating life is prolonged by saving energy, which may reduce available processing time. Mobile embedded systems communicating with other participants like other mobiles or radio stations are subject to time guarantees ensuring reliable communication. Thus, methods that save energy by reducing processing time are not only subject to available processing time but subject to the embedded system's time guarantees. To perform parameter optimisations offline, decisions can be taken early at design time, avoiding further computations at run-time. Especially, to compute processor shutdown durations offline, no extra circuitry to monitor system behaviour and to wake up the processor needs to be designed, deployed, or power supplied: only a timer is required. In this work, software tasks are considered sharing one processor. The scheduling algorithm earliest deadline first is assumed, and per-task, a relative deadline is assumed. Tasks may be instantiated arbitrarily as long as this occurrence behaviour is given in the notion of event streams. Scaling of the processor's voltage and processor shutdown are taken into account as methods for saving energy. With given per task worst-case execution times and the tasks' event streams, the real-time feasibility of the energy optimised solutions is proven. The decision which energy saving solution provides longest operating life is made with the help of a battery model. The used real-time feasibility test has the advantage that it can be approximated: this yields an adjustable number of linear optimisation constraints. Reducing the processor's voltage reduces processor frequency, therefore, execution times increase. The resulting slowdown becomes the

  19. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

    Science.gov (United States)

    Lane, Rebecca K.; Borror, Megan B.; Bokov, Alex F.; Link, Christopher D.; Rea, Shane L.

    2016-01-01

    Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C. elegans not only adapts to disruption of the mitochondrial electron transport chain, but in many instances responds with extended lifespan. Studies have shown various retrograde responses are activated in these animals, including the well-studied ATFS-1-dependent mitochondrial unfolded protein response (UPRmt). Such processes fall under the greater rubric of cellular surveillance mechanisms. Here we identify a novel p38 signaling cascade that is required to extend life when the mitochondrial electron transport chain is disrupted in worms, and which is blocked by disruption of the Mitochondrial-associated Degradation (MAD) pathway. This novel cascade is defined by DLK-1 (MAP3K), SEK-3 (MAP2K), PMK-3 (MAPK) and the reporter gene Ptbb-6::GFP. Inhibition of known mitochondrial retrograde responses does not alter induction of Ptbb-6::GFP, instead induction of this reporter often occurs in counterpoint to activation of SKN-1, which we show is under the control of ATFS-1. In those mitochondrial bioenergetic mutants which activate Ptbb-6::GFP, we find that dlk-1, sek-3 and pmk-3 are all required for their life extension. PMID:27420916

  20. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.

    Directory of Open Access Journals (Sweden)

    Erin Munkácsy

    2016-07-01

    Full Text Available Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C. elegans not only adapts to disruption of the mitochondrial electron transport chain, but in many instances responds with extended lifespan. Studies have shown various retrograde responses are activated in these animals, including the well-studied ATFS-1-dependent mitochondrial unfolded protein response (UPRmt. Such processes fall under the greater rubric of cellular surveillance mechanisms. Here we identify a novel p38 signaling cascade that is required to extend life when the mitochondrial electron transport chain is disrupted in worms, and which is blocked by disruption of the Mitochondrial-associated Degradation (MAD pathway. This novel cascade is defined by DLK-1 (MAP3K, SEK-3 (MAP2K, PMK-3 (MAPK and the reporter gene Ptbb-6::GFP. Inhibition of known mitochondrial retrograde responses does not alter induction of Ptbb-6::GFP, instead induction of this reporter often occurs in counterpoint to activation of SKN-1, which we show is under the control of ATFS-1. In those mitochondrial bioenergetic mutants which activate Ptbb-6::GFP, we find that dlk-1, sek-3 and pmk-3 are all required for their life extension.

  1. Use of Plantago major seed mucilage as a novel edible coating incorporated with Anethum graveolens essential oil on shelf life extension of beef in refrigerated storage.

    Science.gov (United States)

    Behbahani, Behrooz Alizadeh; Shahidi, Fakhri; Yazdi, Farideh Tabatabaei; Mortazavi, Seyed Ali; Mohebbi, Mohebbat

    2017-01-01

    In this study, Plantago major seed mucilage (PMSM) was extracted from whole seeds using hot-water extraction (HWE). The dill (D) essential oil components were identified through gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) and its antioxidant properties were examined through the methods of 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP) and ß-carotene-linoleic acid assay (B-CL). Total phenolic content (TPC) was characterized through the Folin-Ciocalteu method and the antimicrobial effect was evaluated on 10 pathogenic microorganisms. PMSM edible coating incorporated were prepared in four different concentrations of essential oils, including 0, 0.5, 1 and 1.5% (w/w). The control and the coated beef samples were analyzed periodically for microbiological (total viable count, psychrotrophic count, Escherichia coli, Staphylococcus aureus and fungi), chemical (thiobarbituric acid, peroxide value and pH), and sensory characteristics. The IC50, FRAP, B-CL and TPC of the dill essential oil were equal to 11.44μg/ml, 9.45mmol/g, 82.86 and 162.65μg/ml GAE, respectively. PMSM extended the microbial shelf life of beef by 3days, whereas the PMSM+0.5%D, PMSM+1%D and PMSM+1.5%D resulted in a significant shelf life extension of the beef by 6, 9 and 9days, respectively, as compared to the control samples.

  2. USING OF NON-DESTRUCTIVE TEST OF ACCOUSTIC EMISSION FOR PROLONGING THE OPERATION LIFE OF COMPOSITE PRESSURE CYLINDERS

    Directory of Open Access Journals (Sweden)

    Zdeněk CÁB1

    2016-12-01

    Full Text Available Financial crisis in the years 2008 to 2013 had a negative effects also in a state administration, and as well in a purchase, renewing and services of technical means of fire protection. Under the terms of School educational and vocational establishment of the Fire and Rescue Service of the Czech republic (FRS CR, center in Frydek - Mistek, this condition was fully displayed at the FRS CR at the state of composite pressure cylinders (PCs, that are from the point of view of operation of the breathing apparatuses, and other technical means such as bags, sealing means, means for works on water, that are inevitable for their operability. In this article prolongation of an operation life of PCs is described, on the basis of supplementary nondestructive acoustic emission testing (AT, that is a part of hydraulic pressure test. In conclusion it is written the state of PCs after the operation life having been prolonged and before their final decommissioning.

  3. An assessment of quality of life of operated cases of esophageal atresia in the community

    Directory of Open Access Journals (Sweden)

    Harshjeet Singh Bal

    2016-01-01

    Full Text Available Aims: To evaluate the outcome of the operated children of esophageal atresia (EA focusing on their early and late morbidity and mortality and quality of life (QoL of survivors. Settings and Design: A cross-sectional follow-up with retrospective analysis of available medical and surgical records of children who underwent repair for EA. Materials and Methods: The medical records of the children who underwent repair for EA during the period from 2000 to 2011 at the Christian Medical College Hospital, Vellore, were collected retrospectively. Patients with parents were invited to visit the hospital for follow-up and nutritional status, digestive and respiratory symptoms, status of associated anomalies and QoL assessment of children done. QoL assessment was done using the PedsQL™ 4.0 generic core scales questionnaire comprising 4 scale scores: physical, emotional, social functioning, and school functioning. Mean scores are calculated based on a 5-point response scale for each item and transformed to a 0-100 scale with a higher score representing better QoL. Statistical Analysis Used: Statistical Package for Social Sciences (SPSS version 16 using Chi-square or Fisher′s exact test. Results: Of 79 patients operated during the said period, there were 10 deaths and a total of 69 (87% children survived. Of the 66 patients available for follow-up, we interviewed 30 parents and children while for the remaining 36 children, out-patients charts were reviewed retrospectively. Mean follow-up duration was 3.56 years. The height and weight for age measurement showed 47% and 56% of children respectively as below the 5 th percentile. Main problems faced by operated EA children were of the respiratory (26% and gastroesophageal (36% tracts. In spite of the mentioned problems faced, the overall QoL of this group appeared good. In 23 of 30 patients, who answered PedsQL™ , more than 70% had scores >85 out of 100 in QoL scoring. Conclusions: While survivals of the

  4. The effect of organic manures in soilless culture on shelf-life extension of strawberry fruit (Fragaria × ananassa Duch. cv. Camarosa

    Directory of Open Access Journals (Sweden)

    S. Bidaki

    2014-07-01

    Full Text Available   Growing media could affect quality and shelf life of strawberry fruits. In the present study, effect of seven growing media including a control medium (50% cocopeat + 50% perlite v/v , and media supplemented with either 10, 20 and 40% of vermicompost or cattle manure in a completely randomized design with three replications was studied on postharvest quality and shelf life extension of Camarosa strawberry fruits . Freshly picked strawberry fruits were submerged in 1 mM putrescine solution for 5 minutes and after being air-dried at room temperature, were kept in plastic containers at 4 ºC refrigerator. After 15 days, total soluble solids ( TSS, total acidity (TA, TSS/TA ratio, fruit firmness and the percentage of fruit weight loss were determined . The results of analysis of variance showed that growing media had significant effect on fruit firmness, TA, TSS, TSS/TA ratio and percentage of fruit weight loss. The lowest fruit weight loss (16.2% belonged to 10% cattle manure medium and the highest weight loss (36% was observed in control medium. The highest fruit TSS content (19.13% was observed in the growing medium containing 40% vermicompost. Since soilless culture growing media of strawberry are pathogen-free, no fruit was rotted before or after the harvest. Therefore, by using organic fertilizers in growing media, not only there is no need to use chemical fungicides, but also it would be possible to increase postharvest shelf life of strawberry fruits.

  5. Preventive maintenance and life time assessment with respect to cyclic operation; Foerebyggande underhaall och livslaengdsbedoemning med avseende paa cyklisk drift

    Energy Technology Data Exchange (ETDEWEB)

    Storesund, Jan

    2011-03-15

    Procedures that may be used for the life time assessments and growth laws for failure mechanisms with respect to cyclic operation has been compiled. Experience and analyzes of the effects of cyclical operation of steam drums, steam boxes, steam accumulators and valves has been compiled. For the strain-induced corrosion cracking in steam drums a correlation between the voltage level and the crack growth rate has been developed.

  6. Energy-Efficient Through-Life Smart Design, Manufacturing and Operation of Ships in an Industry 4.0 Environment

    Directory of Open Access Journals (Sweden)

    Joo Hock Ang

    2017-04-01

    Full Text Available Energy efficiency is an important factor in the marine industry to help reduce manufacturing and operational costs as well as the impact on the environment. In the face of global competition and cost-effectiveness, ship builders and operators today require a major overhaul in the entire ship design, manufacturing and operation process to achieve these goals. This paper highlights smart design, manufacturing and operation as the way forward in an industry 4.0 (i4 era from designing for better energy efficiency to more intelligent ships and smart operation through-life. The paper (i draws parallels between ship design, manufacturing and operation processes, (ii identifies key challenges facing such a temporal (lifecycle as opposed to spatial (mass products, (iii proposes a closed-loop ship lifecycle framework and (iv outlines potential future directions in smart design, manufacturing and operation of ships in an industry 4.0 value chain so as to achieve more energy-efficient vessels. Through computational intelligence and cyber-physical integration, we envision that industry 4.0 can revolutionise ship design, manufacturing and operations in a smart product through-life process in the near future.

  7. The need for operating guidelines and a decision making framework applicable to the discovery of non-intelligent extraterrestrial life

    Science.gov (United States)

    Race, Margaret S.; Randolph, Richard O.

    While formal principles have been adopted for the eventuality of detecting intelligent life in our galaxy (SETI Principles), no such guidelines exist for the discovery of non-intelligent extraterrestrial life within the solar system. Current scientifically based planetary protection policies for solar system exploration address how to undertake exploration, but do not provide clear guidance on what to do if and when life is detected. Considering that martian life could be detected under several different robotic and human exploration scenarios in the coming decades, it is appropriate to anticipate how detection of non-intelligent, microbial life could impact future exploration missions and activities, especially on Mars. This paper discusses a proposed set of interim guidelines based loosely on the SETI Principles and addresses issues extending from the time of discovery through future handling and treatment of extraterrestrial life on Mars or elsewhere. Based on an analysis of both scientific and ethical considerations, there is a clear need for developing operating protocols applicable at the time of discovery and a decision making framework that anticipates future missions and activities, both robotic and human. There is growing scientific confidence that the discovery of extraterrestrial life in some form is nearly inevitable. If and when life is discovered beyond Earth, non-scientific dimensions may strongly influence decisions about the nature and scope of future missions and activities. It is appropriate to encourage international discussion and consideration of the issues prior to an event of such historical significance.

  8. EXPERIENCES OF OPERATING AND STUDYING IN SECOND LIFE: Conclusions for Training Design

    Directory of Open Access Journals (Sweden)

    Riitta LISKI

    2011-08-01

    Full Text Available The Educational Association Citizens´ Forum SKAF ry is an educational institution for non-formal education. The Citizens’ Forum has been an active Second Life participant since 2007, researching its potential and challenges in educational use and non-governmental organisation activities. The first training sessions were organised in 2008 on a block of land rented from EduFinland I island. Later, ownership was acquired of the Suomi ry (Finland ry island, which was customised to serve Finnish organisations and non-governmental organisations (further NGO. The citizens’ Forum’s training courses have covered training in Second Life and the organisation of cooperative meetings and various other events in Second Life. The overall length of training sessions has been one month. Each course has consisted of 3-5. 1.5 hour meetings in Second Life and interim tasks completed either individually or in small groups. In addition to Second Life, Moodle, an online learning environment, has been employed in which tasks, experiences and feedback have been gathered and which has also contained written summaries of what was learned during the Second Life meetings. The Second Life environment has also been regularly utilised in Citizens’ Forum staff and various other work group work related meetings.Funding and ventures 2008: Ministry of Education special funding, Initiation of Second Life courses and construction of environment 2009-2010: ESF programme Open Learning Environments-AVO venture, development and implementation of Second Life educational programmes.This article is based on practical experiences gained from Ø suitability of cooperative educational processes for Second LifeØ constructing a Second Life environment for educational useØ suitability of Second Life technology and tools for education and team workØ practical methods related to educational situations .

  9. Orthogonal assembly of a designed ankyrin repeat protein-cytotoxin conjugate with a clickable serum albumin module for half-life extension.

    Science.gov (United States)

    Simon, Manuel; Frey, Raphael; Zangemeister-Wittke, Uwe; Plückthun, Andreas

    2013-11-20

    The generation of drug conjugates for safe and effective tumor targeting requires binding proteins tolerant to functionalization by rational engineering. Here, we show that Designed Ankyrin Repeat Proteins (DARPins), a novel class of binding proteins not derived from antibodies, can be used as building blocks for facile orthogonal assembly of bioconjugates for tumor targeting with tailored properties. DARPin Ec1, which targets the Epithelial Cell Adhesion Molecule (EpCAM), was genetically modified with a C-terminal cysteine for conjugation of the small molecule cytotoxin monomethylauristatin F (MMAF). In addition, it was N-terminally functionalized by metabolic introduction of the non-natural amino acid azidohomoalanine to enable linkage of site-specifically dibenzocyclooctyne-modified mouse serum albumin (MSA) for half-life extension using Cu(I)-free click chemistry. The conjugate MSA-Ec1-MMAF was assembled to obtain high yields of a pure and stable drug conjugate as confirmed by various analytical methods and in functional assays. The orthogonality of the assembly led to a defined reaction product and preserved the functional properties of all modules, including EpCAM-specific binding and internalization, FcRn binding mediated by MSA, and cytotoxic potency. Linkage of MMAF to the DARPin increased receptor-specific uptake of the drug while decreasing nonspecific uptake, and further coupling of the conjugate to MSA enhanced this effect. In mice, albumin conjugation increased the serum half-life from 11 min to 17.4 h, resulting in a more than 22-fold increase in the area-under-the-curve (AUC). Our data demonstrate the promise of the DARPin format for facile modular assembly of drug conjugates with improved pharmacokinetic performance for tumor targeting.

  10. Combined effect of an oxygen absorber and oregano essential oil on shelf life extension of rainbow trout fillets stored at 4 degrees C.

    Science.gov (United States)

    Mexis, S F; Chouliara, E; Kontominas, M G

    2009-09-01

    In the present study the combined effect of an O2 absorber and oregano essential oil (0.4% v/w) on shelf life extension of rainbow trout fillets (Onchorynchus mykiss) stored under refrigeration (4 degrees C) was investigated. The study was based on microbiological [TVC, Pseudomonas spp., Lactic Acid Bacteria, H2S-producing bacteria including Shewanella putrefaciens, Enterobacteriaceae and Clostridium spp.), physicochemical (pH, PV, TBA, TVBN and Drip loss) and sensory (odor, taste) changes occurring in the product as a function of treatment and storage time. Aerobically-packaged rainbow trout fillets stored at 4 degrees C were taken as control samples. Results showed that TVC exceeded 7 log cfu/g on day 4 of storage for control samples, day 7-8 for samples containing oregano oil, day 9 for samples containing the O2 absorber and day 12-13 for samples containing the O2 absorber and oregano oil. Pseudomonas spp., Enterobacteriaceae and LAB were only partially inhibited by the O2 absorber and/or the oregano oil. In all cases the inhibition effect was more pronounced when the combination of O2 absorber with oregano essential oil was used. pH decreased from an initial value of 6.65-6.09 and subsequently increased to 6.86 due to formation of protein decomposition products. % Drip loss ranged between 7% and 11-12% at the end of the product shelf life. PV values ranged between 11.4 and 27.0 meq O2/kg oil while malondialdehyde (MDA) ranged between 9.6 and 24.5 mg/kg. TVBN ranged between 10.6 and 54.6 mg/kg at the time of sensory rejection. Sensory shelf life was 4 days for the control samples, 7-8 days for samples containing oregano oil, 13-14 days for samples containing the O2 absorber and 17 days for samples containing the O2 absorber plus oregano oil.

  11. Extension of radiative transfer code MOMO, matrix-operator model to the thermal infrared - Clear air validation by comparison to RTTOV and application to CALIPSO-IIR

    Science.gov (United States)

    Doppler, Lionel; Carbajal-Henken, Cintia; Pelon, Jacques; Ravetta, François; Fischer, Jürgen

    2014-09-01

    1-D radiative transfer code Matrix-Operator Model (MOMO), has been extended from [0.2-3.65 μm] the band to the whole [0.2-100 μm] spectrum. MOMO can now be used for the computation of a full range of radiation budgets (shortwave and longwave). This extension to the longwave part of the electromagnetic radiation required to consider radiative transfer processes that are features of the thermal infrared: the spectroscopy of the water vapor self- and foreign-continuum of absorption at 12 μm and the emission of radiation by gases, aerosol, clouds and surface. MOMO's spectroscopy module, Coefficient of Gas Absorption (CGASA), has been developed for computation of gas extinction coefficients, considering continua and spectral line absorptions. The spectral dependences of gas emission/absorption coefficients and of Planck's function are treated using a k-distribution. The emission of radiation is implemented in the adding-doubling process of the matrix operator method using Schwarzschild's approach in the radiative transfer equation (a pure absorbing/emitting medium, namely without scattering). Within the layer, the Planck-function is assumed to have an exponential dependence on the optical-depth. In this paper, validation tests are presented for clear air case studies: comparisons to the analytical solution of a monochromatic Schwarzschild's case without scattering show an error of less than 0.07% for a realistic atmosphere with an optical depth and a blackbody temperature that decrease linearly with altitude. Comparisons to radiative transfer code RTTOV are presented for simulations of top of atmosphere brightness temperature for channels of the space-borne instrument MODIS. Results show an agreement varying from 0.1 K to less than 1 K depending on the channel. Finally MOMO results are compared to CALIPSO Infrared Imager Radiometer (IIR) measurements for clear air cases. A good agreement was found between computed and observed radiance: biases are smaller than 0.5 K

  12. Phenix reactor: a review of 35 year long operating life; Le reacteur Phenix: bilan de 35 ans de fonctionnement

    Energy Technology Data Exchange (ETDEWEB)

    Martin, L.; Dall' Ava, D.; Rochwerger, D.; Goux, D. [CEA Marcoule 30 (France); Guidez, J.; Martin, Ph.; Seran, J.L. [CEA Saclay 91 - Gif sur Yvette (France); Sauvage, J.F.; Prele, G.; Guihard, J. [Electricite de France (EDF), 75 - Paris (France); Bernardin, B.; Vanier, M.; Zaetta, A.; Latge, Ch. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Fontaine, B.; Jolly, J.A.; Gros, J.; Pepe, D. [CEA Marcoule, Centrale Phenix, 30 (France); Pelletier, M.; Pillon, S. [CEA Cadarache, Dept. d' Etudes des Combustibles, 13 - Saint Paul lez Durance (France); Escaravage, C.; Gelineau, O.; Dupraz, R.; Dirat, J.F.; Giraud, M. [AREVA NP, 92 - Paris la Defense (France); Michaille, P. [CEA Dam, DP2I, Mar (France)

    2009-01-15

    Phenix reactor that was commissioned in 1973, had its final shutdown during the beginning of 2009. This series of articles presents the main contributions of Phenix over its 35 years of operating life in material sciences, the handling of sodium, the design of fast reactors, core physics and reactor safety. Other articles recall the feedback experience on particular components like sodium pumps, steam generators or intermediate heat exchangers and about reactor maintenance. This power plant was first an experimental reactor that, with its hot cells, has performed important irradiation programs concerning mainly fast reactor technology and transmutation as a tool for burning actinides. One article reviews the environmental impact of this reactor over its operating life in terms of waste production and dosimetry. (A.C.)

  13. Reduce operational cost and extend the life of pipeline infrastructure by automating remote cathodic protection systems

    Energy Technology Data Exchange (ETDEWEB)

    Rosado, Elroy [Freewave Technologies, Inc., Boulder, CO (United States). Latin America

    2009-07-01

    Energy and Pipeline Companies wrestle to control operating costs largely affected by new government regulations, ageing buried metal assets, rising steel prices, expanding pipeline operations, new interference points, HCA encroachment, restrictive land use policies, heightened network security, and an ageing soon-to-retire work force. With operating costs on the rise, seemingly out of control, many CP and Operations Professionals look to past best practices in cost containment through automation. Many companies achieve solid business results through deployment of telemetry and SCADA automation of remote assets and now hope to expand this success to further optimize operations by automating remote cathodic protection systems. This presentation will provide examples of how new remote cathodic protection systems are helping energy and pipeline companies address the growing issue of the aging pipeline infrastructure and reduce their costs while optimizing their operations. (author)

  14. Remaining useful life estimation for deteriorating systems with time-varying operational conditions and condition-specific failure zones

    Institute of Scientific and Technical Information of China (English)

    Li Qi; Gao Zhanbao; Tang Diyin; Li Baoan

    2016-01-01

    Dynamic time-varying operational conditions pose great challenge to the estimation of system remaining useful life (RUL) for the deteriorating systems. This paper presents a method based on probabilistic and stochastic approaches to estimate system RUL for periodically moni-tored degradation processes with dynamic time-varying operational conditions and condition-specific failure zones. The method assumes that the degradation rate is influenced by specific oper-ational condition and moreover, the transition between different operational conditions plays the most important role in affecting the degradation process. These operational conditions are assumed to evolve as a discrete-time Markov chain (DTMC). The failure thresholds are also determined by specific operational conditions and described as different failure zones. The 2008 PHM Conference Challenge Data is utilized to illustrate our method, which contains mass sensory signals related to the degradation process of a commercial turbofan engine. The RUL estimation method using the sensor measurements of a single sensor was first developed, and then multiple vital sensors were selected through a particular optimization procedure in order to increase the prediction accuracy. The effectiveness and advantages of the proposed method are presented in a comparison with exist-ing methods for the same dataset.

  15. A life cycle cost economics model for automation projects with uniformly varying operating costs. [applied to Deep Space Network and Air Force Systems Command

    Science.gov (United States)

    Remer, D. S.

    1977-01-01

    The described mathematical model calculates life-cycle costs for projects with operating costs increasing or decreasing linearly with time. The cost factors involved in the life-cycle cost are considered, and the errors resulting from the assumption of constant rather than uniformly varying operating costs are examined. Parameters in the study range from 2 to 30 years, for project life; 0 to 15% per year, for interest rate; and 5 to 90% of the initial operating cost, for the operating cost gradient. A numerical example is presented.

  16. A life cycle cost economics model for automation projects with uniformly varying operating costs. [applied to Deep Space Network and Air Force Systems Command

    Science.gov (United States)

    Remer, D. S.

    1977-01-01

    The described mathematical model calculates life-cycle costs for projects with operating costs increasing or decreasing linearly with time. The cost factors involved in the life-cycle cost are considered, and the errors resulting from the assumption of constant rather than uniformly varying operating costs are examined. Parameters in the study range from 2 to 30 years, for project life; 0 to 15% per year, for interest rate; and 5 to 90% of the initial operating cost, for the operating cost gradient. A numerical example is presented.

  17. Creep life management system for a turbine engine and method of operating the same

    Science.gov (United States)

    Tralshawala, Nilesh; Miller, Harold Edward; Badami, Vivek Venugopal; Vittal, Sameer; Sexton, Daniel White

    2016-11-15

    A creep life management system includes at least one sensor apparatus coupled to a first component. The at least one sensor apparatus is configured with a unique identifier. The creep life management system also includes at least one reader unit coupled to a second component. The at least one reader unit is configured to transmit an interrogation request signal to the at least one sensor apparatus and receive a measurement response signal transmitted from the at least one sensor apparatus. The creep life management system further includes at least one processor programmed to determine a real-time creep profile of the first component as a function of the measurement response signal transmitted from the at least one sensor apparatus.

  18. IPO operational algorithm teams throughout the life cycle of NPOESS environmental satellites

    Science.gov (United States)

    Duda, James L.; Emch, Pamela G.

    2004-09-01

    The tri-agency Integrated Program Office (IPO) created Operational Algorithm Teams (OATs) in 1997 to provide scientific advice for managing the development and operation of the National Polar-orbiting Operational Environmental Satellite System (NPOESS). The scientific advice focuses on (1) assuring sound science in instrument and systems design in addition to (2) assuring development and implementation of sound scientific algorithms. This paper outlines the role of IPO operational algorithm teams from mission conception, through instrument design and development, algorithm science code development and conversion to operational code, data processing system implementation, calibration, validation, and, finally, operational data and products distribution to a range of users for weather, national security, and climate science. The composition of the algorithm science teams changes substantially as the sensors and algorithms are developed, tested, integrated, launched, become operational, and age on-orbit. The concept of leveraging our heritage scientists has proven successful with many tangible benefits to the government, the contractor teams, and, ultimately, the nation's taxpayers.

  19. Training and certification program of the operating staff for a 90-day test of a regenerative life support system

    Science.gov (United States)

    1972-01-01

    Prior to beginning a 90-day test of a regenerative life support system, a need was identified for a training and certification program to qualify an operating staff for conducting the test. The staff was responsible for operating and maintaining the test facility, monitoring and ensuring crew safety, and implementing procedures to ensure effective mission performance with good data collection and analysis. The training program was designed to ensure that each operating staff member was capable of performing his assigned function and was sufficiently cross-trained to serve at certain other positions on a contingency basis. Complicating the training program were budget and schedule limitations, and the high level of sophistication of test systems.

  20. A Further Examination of Operational Availability in Life Cycle Cost Models

    Science.gov (United States)

    1984-09-01

    supportabil i t/, where opePational availability acti: as a measurable surrogate for supportabil ’ty. The modified model uses the DOD’s fAIG approved...of Opep ational I Availabiiity in Life Cycle Cost Modelsthe orientatisn process was greatly simpi ified. in that earl i er ef ort the ku thor had

  1. Remaining useful life estimation for deteriorating systems with time-varying operational conditions and condition-specific failure zones

    Directory of Open Access Journals (Sweden)

    Li Qi

    2016-06-01

    Full Text Available Dynamic time-varying operational conditions pose great challenge to the estimation of system remaining useful life (RUL for the deteriorating systems. This paper presents a method based on probabilistic and stochastic approaches to estimate system RUL for periodically monitored degradation processes with dynamic time-varying operational conditions and condition-specific failure zones. The method assumes that the degradation rate is influenced by specific operational condition and moreover, the transition between different operational conditions plays the most important role in affecting the degradation process. These operational conditions are assumed to evolve as a discrete-time Markov chain (DTMC. The failure thresholds are also determined by specific operational conditions and described as different failure zones. The 2008 PHM Conference Challenge Data is utilized to illustrate our method, which contains mass sensory signals related to the degradation process of a commercial turbofan engine. The RUL estimation method using the sensor measurements of a single sensor was first developed, and then multiple vital sensors were selected through a particular optimization procedure in order to increase the prediction accuracy. The effectiveness and advantages of the proposed method are presented in a comparison with existing methods for the same dataset.

  2. Dams life. Dams in operation; La vie des barrages. Barrages en exploitation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This paper summarizes the conclusions of the annual inspections of French dams in operation (fissures, water oozing, concrete swelling etc..). Only the observations which require a special attention are reported. (J.S.)

  3. Lithium Battery Electrolytes for Long Cycle Life and Wide Operating Temperature Range Project

    Data.gov (United States)

    National Aeronautics and Space Administration — New lithium battery electrolytes must be developed if these they are to be successfully deployed on NASA Platforms operating at -100oC to +100oC. Giner, Inc. has...

  4. An Optimal Operating Strategy for Battery Life Cycle Costs in Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Yinghua Han

    2014-01-01

    Full Text Available Impact on petroleum based vehicles on the environment, cost, and availability of fuel has led to an increased interest in electric vehicle as a means of transportation. Battery is a major component in an electric vehicle. Economic viability of these vehicles depends on the availability of cost-effective batteries. This paper presents a generalized formulation for determining the optimal operating strategy and cost optimization for battery. Assume that the deterioration of the battery is stochastic. Under the assumptions, the proposed operating strategy for battery is formulated as a nonlinear optimization problem considering reliability and failure number. And an explicit expression of the average cost rate is derived for battery lifetime. Results show that the proposed operating strategy enhances the availability and reliability at a low cost.

  5. Premium cost optimization of operational and maintenance of green building in Indonesia using life cycle assessment method

    Science.gov (United States)

    Latief, Yusuf; Berawi, Mohammed Ali; Basten, Van; Budiman, Rachmat; Riswanto

    2017-06-01

    Building has a big impact on the environmental developments. There are three general motives in building, namely the economy, society, and environment. Total completed building construction in Indonesia increased by 116% during 2009 to 2011. It made the energy consumption increased by 11% within the last three years. In fact, 70% of energy consumption is used for electricity needs on commercial buildings which leads to an increase of greenhouse gas emissions by 25%. Green Building cycle costs is known as highly building upfront cost in Indonesia. The purpose of optimization in this research improves building performance with some of green concept alternatives. Research methodology is mixed method of qualitative and quantitative approaches through questionnaire surveys and case study. Assessing the successful of optimization functions in the existing green building is based on the operational and maintenance phase with the Life Cycle Assessment Method. Choosing optimization results were based on the largest efficiency of building life cycle and the most effective cost to refund.

  6. Wind turbine blade life-time assessment model for preventive planning of operation and maintenance

    DEFF Research Database (Denmark)

    Florian, Mihai; Sørensen, John Dalsgaard

    2014-01-01

    Out of the total wind turbine failure events, blade damage accounts for a substantial part, with some studies estimating it at around 23%. Current operation and maintenance (O&M) practices typically make use of corrective type maintenance as the basic approach, implying high costs for repair...

  7. Wind Turbine Blade Life-Time Assessment Model for Preventive Planning of Operation and Maintenance

    DEFF Research Database (Denmark)

    Florian, Mihai; Sørensen, John Dalsgaard

    2015-01-01

    Out of the total wind turbine failure events, blade damage accounts for a substantial part, with some studies estimating it at around 23%. Current operation and maintenance (O&M) practices typically make use of corrective type maintenance as the basic approach, implying high costs for repair...

  8. Post operative radiation therapy in endometrial carcinoma : reducing overtreatment and improving quality of life

    NARCIS (Netherlands)

    Nout, Remi Abubakar

    2013-01-01

    This thesis describes the results of the first en second Post Operative Radiation Therapy in Endometrial Cancer (PORTEC) trials. The 15-year results of PORTEC-1 confirm the importance of the prognostic factors age, grade and depth of myometrial invasion for selection of patients with

  9. J-对称微分算子的J-对称扩张的J-辛几何刻画%Complex J-Symplectic Geometry Characterization for J-Symmetric Extensions of J-Symmetric Differential Operators

    Institute of Scientific and Technical Information of China (English)

    王万义; 孙炯

    2003-01-01

    本文利用J-辛几何,刻画了J-对称微分算子的J-对称扩张.%We give complex J-symplectic geometry characterizations for J-symmetric exten-sions of J-symmetric ordinary differential operators.

  10. Operational amplifiers

    CERN Document Server

    Dostal, Jiri

    1993-01-01

    This book provides the reader with the practical knowledge necessary to select and use operational amplifier devices. It presents an extensive treatment of applications and a practically oriented, unified theory of operational circuits.Provides the reader with practical knowledge necessary to select and use operational amplifier devices. Presents an extensive treatment of applications and a practically oriented, unified theory of operational circuits

  11. Virtualization of Legacy Instrumentation Control Computers for Improved Reliability, Operational Life, and Management.

    Science.gov (United States)

    Katz, Jonathan E

    2017-01-01

    Laboratories tend to be amenable environments for long-term reliable operation of scientific measurement equipment. Indeed, it is not uncommon to find equipment 5, 10, or even 20+ years old still being routinely used in labs. Unfortunately, the Achilles heel for many of these devices is the control/data acquisition computer. Often these computers run older operating systems (e.g., Windows XP) and, while they might only use standard network, USB or serial ports, they require proprietary software to be installed. Even if the original installation disks can be found, it is a burdensome process to reinstall and is fraught with "gotchas" that can derail the process-lost license keys, incompatible hardware, forgotten configuration settings, etc. If you have running legacy instrumentation, the computer is the ticking time bomb waiting to put a halt to your operation.In this chapter, I describe how to virtualize your currently running control computer. This virtualized computer "image" is easy to maintain, easy to back up and easy to redeploy. I have used this multiple times in my own lab to greatly improve the robustness of my legacy devices.After completing the steps in this chapter, you will have your original control computer as well as a virtual instance of that computer with all the software installed ready to control your hardware should your original computer ever be decommissioned.

  12. Characteristics of fishing operations, environment and life history contributing to small cetacean bycatch in the northeast Atlantic.

    Directory of Open Access Journals (Sweden)

    Susie Brown

    Full Text Available Fisheries bycatch is a key threat to cetacean species globally. Managing the impact requires an understanding of the conditions under which animals are caught and the sections of the population affected. We used observer data collected on an albacore tuna gillnet fishery in the northeast Atlantic, to assess operational and environmental factors contributing to bycatch of common and striped dolphins, using generalised linear models and model averaging. Life history demographics of the captured animals were also investigated. In both species, young males dominated the catch. The age ratio of common dolphins was significantly different from that estimated for the population in the region, based on life tables (G = 17.1, d.f. = 2, p = 0.002. Skewed age and sex ratios may reflect varying vulnerability to capture, through differences in behaviour or segregation in populations. Adult females constituted the second largest portion of the bycatch for both species, with potential consequences for population sustainability. Depth was the most important parameter influencing bycatch of both species and reflected what is known about common and striped dolphin habitat use in the region as the probability of catching common dolphins decreased, and striped dolphins increased, with increasing depth. Striped dolphin capture was similarly influenced by the extent to which operations were conducted in daylight, with the probability of capture increasing with increased operations in the pre-sunset and post-sunrise period, potentially driven by increased ability of observers to record animals during daylight operations, or by diurnal movements increasing contact with the fishery. Effort, based on net length and soak time, had little influence on the probability of capturing either species. Our results illustrate the importance of assessing the demographic of the animals captured during observer programmes and, perhaps more importantly, suggest that effort

  13. Environmental impact assessment of a package type IFAS reactor during construction and operational phases: a life cycle approach.

    Science.gov (United States)

    Singh, Nitin Kumar; Singh, Rana Pratap; Kazmi, Absar Ahmad

    2017-05-01

    In the present study, a life cycle assessment (LCA) approach was used to analyse the environmental impacts associated with the construction and operational phases of an integrated fixed-film activated sludge (IFAS) reactor treating municipal wastewater. This study was conducted within the boundaries of a research project that aimed to investigate the implementation related challenges of a package type IFAS reactor from an environmental perspective. Along with the LCA results of the construction phase, a comparison of the LCA results of seven operational phases is also presented in this study. The results showed that among all the inputs, the use of stainless steel in the construction phase caused the highest impact on environment, followed by electricity consumption in raw materials production. The impact of the construction phase on toxicity impact indicators was found to be significant compared to all operational phases. Among the seven operational phases of this study, the dissolved oxygen phase III, having a concentration of ∼4.5 mg/L, showed the highest impact on abiotic depletion, acidification, global warming, ozone layer depletion, human toxicity, fresh water eco-toxicity, marine aquatic eco-toxicity, terrestrial eco-toxicity, and photochemical oxidation. However, better effluent quality in this phase reduced the eutrophication load on environment.

  14. Changes in Health-Related Quality of Life During Rehabilitation in Patients With Operable Lung Cancer

    DEFF Research Database (Denmark)

    Sommer, Maja S.; Trier, Karen; Vibe-Petersen, Jette

    2016-01-01

    comprised supervised group exercise program, 2 hours weekly for 12 weeks, combined with individual counseling. The study endpoints were self-reported HRQoL (Functional Assessment of Cancer Therapy-Lung, European Organization for Research and Treatment in Cancer-Quality of Life Questionnaire-QLQ-C30, Short......-Form-36) and self-reported distress, anxiety, depression, and social support (National Comprehensive Cancer Network Distress Thermometer, Hospital Anxiety and Depression Scale, Multidimensional Scale of Perceived Social Support), measured presurgery, postintervention, 6 months, and 1 year after surgery....... RESULTS: Forty patients were included, 73% of whom completed rehabilitation. Results on emotional well-being (P mental health component score (P = .0004) showed an overall statistically significant improvement during the study. CONCLUSION: This feasibility...

  15. WAYS TO IMPROVE THE RELIABILITY AND OPERATING LIFE OF SMALL-SIZE ELECTROMAGNETIC VALVE

    Directory of Open Access Journals (Sweden)

    Gennadii Zaionchkovskyi

    2015-04-01

    Full Text Available This article considers the main ways of improving the reliability and durability of small-size electromagnetic valves. Major changes in the technical state of the valve components under dynamic operating loads were revealed using the results of resource tests of two-position valves with polarized electromagnetic actuator. Aneffective way for reducing the dynamic loads has proved to be the introduction of the damping element into the kinematic scheme of the electromagnetic valve actuator. Damping elements efficiency in reducing dynamic loads has been confirmed experimentally.

  16. Changes in quality of life and perceptions of general health before and after operation of wind turbines.

    Science.gov (United States)

    Jalali, Leila; Bigelow, Philip; McColl, Stephen; Majowicz, Shannon; Gohari, Mahmood; Waterhouse, Ryan

    2016-09-01

    Ontario is Canada's provincial leader in wind energy, with over 4000 MW of installed capacity supplying approximately five percent of the province's electricity demand. Wind energy is now one of the fastest-growing sources of renewable power in Canada and many other countries. However, its possible negative impact on population health, as a new source of environmental noise, has raised concerns for people living in proximity to wind turbines (WTs). The aims of this study were to assess the effect of individual differences and annoyance on the self-reported general health and health-related quality of life (QOL) of nearby residents, using a pre- and post-exposure design. Prospective cohort data were collected before and after WT operations, from the individuals (n = 43) in Ontario, Canada. General health and QOL metrics were measured using standard scales, such as SF12, life satisfaction scales developed by Diener (SWLS) and the Canadian Community Health Survey (CCHS-SWL). The mean values for the Mental Component Score of SF12 (p = 0.002), SWLS (p < 0.001), and CCHS-SWL (p = 0.044) significantly worsened after WT operation for those participants who had a negative attitude to WTs, who voiced concerns about property devaluation, and/or who reported being visually or noise annoyed.

  17. Aumento da vida útil e microbiologia da carne suína embalada em atmosfera modificada Shelf life extension and microbiology of pork meat packaged in modified atmosphere

    Directory of Open Access Journals (Sweden)

    Sérgio Borges Mano

    2002-01-01

    with either 1.0 L of air (100%, nitrogen (100%, 20/80 or 40/60 CO2/O2 and finally sealed. Samples were subdivided into two batches and stored in walk-in cold rooms at 1 and 7ºC. Samples were taken at different days of storage and pH and gas concentration (CO2/O2/N2 were determined. Likewise, total viable, lactic acid bacteria, Enterobacteriaceae, Brochothrix thermosphacta and Pseudomonas were counted. Bacterial growth parameters were assessed using Gompertz equations. As expected, modified atmosphere packaging extended the pork meat shelf life. However, modified atmospheres enriched with CO2 and at 1ºC showed a greater effectiveness. The samples conserved in MAP enriched in CO2, as much to 7 as to 1ºC, maintained the constant pH during the period of storage. At 1 and 7ºC the lag phases and the duplication times of the total microbiota were progressively larger in the following order: air (100%, N2 (100%, 20/80 and 40/60 CO2/O2. In accordance with the results, it can be concluded that, by as much to 1 as to 7ºC, the use of the modified atmospheres slowed the growth of the spoilage bacteria of pork meat, favoring the extension of the useful life, mainly in the MAP enriched with CO2.

  18. Is there life after Buckley's formocresol? Part II - Development of a protocol for the management of extensive caries in the primary molar.

    Science.gov (United States)

    Patchett, C L; Srinivasan, V; Waterhouse, P J

    2006-05-01

    To produce a working clinical protocol for pulp therapy techniques in the extensively carious primary molar. The International Agency for Research on Cancer has recently classified formaldehyde as carcinogenic to human beings. As such, a medicament that can be used to replace formocresol in clinical practice should be identified. Part I of this paper explored the currently available alternative interventions and materials to formocresol in the form of a narrative review following an extensive literature search. Part II now presents the formation of a specialist group to establish an evidence-based protocol, for the management of the extensively carious primary molar. A protocol and key points document have been developed to assist clinicians in their treatment planning. Areas for further postgraduate training are identified.

  19. Operational Phase Life Cycle Assessment of Select NASA Ground Test Facilities

    Science.gov (United States)

    Sydnor, George H.; Marshall, Timothy J.; McGinnis, Sean

    2011-01-01

    NASA's Aeronautics Test Program (ATP) is responsible for many large, high-energy ground test facilities that accomplish the nation s most advanced aerospace research. In order to accomplish these national objectives, significant energy and resources are consumed. A select group of facilities was analyzed using life-cycle assessment (LCA) to determine carbon footprint and environmental impacts. Most of these impacts stem from electricity and natural gas consumption, used directly at the facility and to generate support processes such as compressed air and steam. Other activities were analyzed but determined to be smaller in scale and frequency with relatively negligible environmental impacts. More specialized facilities use R-134a, R-14, jet fuels, or nitrogen gas, and these unique inputs can have a considerable effect on a facility s overall environmental impact. The results of this LCA will be useful to ATP and NASA as the nation looks to identify its top energy consumers and NASA looks to maximize research output and minimize environmental impact. Keywords: NASA, Aeronautics, Wind tunnel, Keyword 4, Keyword 5

  20. Evaluating life cycle costs of perpetual pavements in China using operational pavement management system

    Directory of Open Access Journals (Sweden)

    Saud A. Sultan

    2016-10-01

    Full Text Available Highway transportation is considered as vital factor in China’s economic growth; many high grade highways have been constructed in China during the last decades. The research and application of perpetual asphalt pavement (PP technology have been deployed in China since 2000. The semi-rigid pavement has been normally considered as typical pavement of high class highways in the design according to the Chinese experience. The objective of this research is to evaluate the performance of different Chinese perpetual pavements using operational pavement management system and to examine its suitability for use in the design and construction of more economical and durable pavements. It has been found that the use of thin asphalt layers over semi-rigid pavement foundation in PP structure will create more sustainable, economical, and durable PP structures in comparison with typical thick asphalt layers PP structures.

  1. Evaluation of Antibacterial properties of the suspension of Ginger, Black Pepper, Vinegar, Honey and its application in Shelf life extension of Agaricus bisporus

    OpenAIRE

    Nitin Jain; Himanshu Karaiya; Kumari Amrita; Swapnil Tiwari; Vishakha Dubey; C. Ramalingam

    2013-01-01

    Suspensions of vinegar, honey, black pepper and ginger were examined for antibacterial activity against Salmonella sp., Pseudomonas sp. and E.coli by agar well diffusion technique. The prepared suspensions were applied on Agaricus bisporus to evaluate suspensions effect for increasing the shelf life of it. Vinegar suspension showed better antibacterial effect and good result on Agaricus bisporus to increase its shelf life as compared to honey suspension. Enzymatic spoilage of Agaricus bisporu...

  2. Increasing the efficiency and lifetime extension of turbine condensers by means of monitoring its condition and operation; Leistungssteigerung und Lebensdauerverlaengerung von Turbinenkondensatoren durch Zustands- und Betriebsueberwachung

    Energy Technology Data Exchange (ETDEWEB)

    Czolkoss, Wolfgang [Taprogge GmbH, Wetter (Germany). Abt. Anwendungstechnik

    2010-07-01

    Loss in capacity and operational availability in steam power plants is often caused by adverse conditions in turbine condensers. Therefore, monitoring the condition and overall operation of the turbine condenser is an important part of maintaining an efficiently operating power station and preventing costly tube replacements. The operation of the tube cleaning system is of particular importance. Reference on monitoring tube cleaning as well as on the detection and elimination of malfunctions are given in order to detect fouling and corrosion problems in due time and to launch remedial measures. (orig.)

  3. Enhancement of the life of refractories through the operational experience of plasma torch melter

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Young Pyo [Technology Institute, Korea Radioactive waste Agency (KORAD), Daejeon (Korea, Republic of); Choi, Jaang Young [Chungnam National University, Daejeon (Korea, Republic of)

    2016-06-15

    The properties of wastes for melting need to be considered to minimize the maintenance of refractory and to discharge the molten slags smoothly from a plasma torch melter. When the nonflammable wastes from nuclear facilities such as concrete debris, glass, sand, etc., are melted, they become acid slags with low basicity since the chemical composition has much more acid oxides than basic oxides. A molten slag does not have good characteristics of discharge and is mainly responsible for the refractory erosion due to its low liquidity. In case of a stationary plasma torch melter with a slant tapping port on the wall, a fixed amount of molten slags remains inside of tapping hole as well as the melter inside after tapping out. Nonmetallic slags keep the temperature higher than melting point of metal because metallic slags located on the bottom of melter by specific gravity difference are simultaneously melted when dual mode plasma torch operates in transferred mode. In order to minimize the refractory erosion, the compatible refractories are selected considering the temperature inside the melter and the melting behavior of slags whether to contact or noncontact with molten slags. An acidic refractory shall not be installed in adjacent to a basic refractory for the resistibility against corrosion.

  4. Improvement in operating conditions of coke oven batteries with long service life

    Energy Technology Data Exchange (ETDEWEB)

    Obertenev, V.N.; Bondarchuk, P.N.; Krut' ko, I.G.; Sheptovitskii, M.S.; Kaftan, Yu.S.; Shul' ga, I.V.; Vol' fovskii, A.G. (Mariupol' skii Koksokhimicheskii Zavod (USSR))

    1991-01-01

    Discusses operation of the coke oven battery No 1 in the Mariupol' coking plant constructed in 1949. Twenty-five of 69 coke oven chambers had liners deformed due to wear. In 1988-1989 a number of failures occurred due to accumulation of pyrolysis products and tar on coke oven walls. Excessive liner wear negatively influenced coking conditions (e.g. reducing the bulk density of charged coal, increasing the buildup on coke oven walls, increasing the density and viscosity of coal tar and content of solid particles in the tar). Increased viscosity and content of solid particles in the tar increased failure rates of a tar transport system. Coal tar properties in the Mariupol' plant and 8 other plants in the USSR are comparatively evaluated. Specific properties of coal tar from the Mariupol' plant and their causes were determined. On the basis of the evaluations coal tar properties were controlled by changing coal mixture composition (content of gas coal was reduced to 32% of G and GZh types). Reducing content of gas coal in the mixtures reduced coke oven failure rate, increased coke compression strength by 0.6% and reduced coke abrasion by 0.25%. 5 refs.

  5. Tool Condition Monitoring and Remaining Useful Life Prognostic Based on a Wireless Sensor in Dry Milling Operations.

    Science.gov (United States)

    Zhang, Cunji; Yao, Xifan; Zhang, Jianming; Jin, Hong

    2016-05-31

    Tool breakage causes losses of surface polishing and dimensional accuracy for machined part, or possible damage to a workpiece or machine. Tool Condition Monitoring (TCM) is considerably vital in the manufacturing industry. In this paper, an indirect TCM approach is introduced with a wireless triaxial accelerometer. The vibrations in the three vertical directions (x, y and z) are acquired during milling operations, and the raw signals are de-noised by wavelet analysis. These features of de-noised signals are extracted in the time, frequency and time-frequency domains. The key features are selected based on Pearson's Correlation Coefficient (PCC). The Neuro-Fuzzy Network (NFN) is adopted to predict the tool wear and Remaining Useful Life (RUL). In comparison with Back Propagation Neural Network (BPNN) and Radial Basis Function Network (RBFN), the results show that the NFN has the best performance in the prediction of tool wear and RUL.

  6. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.

    Science.gov (United States)

    Yen, Kelvin; Patel, Harshil B; Lublin, Alex L; Mobbs, Charles V

    2009-03-01

    The free radical theory of aging is one of the most prominent theories of aging and senescence, but has yet to be definitively proven. If free radicals are the cause of senescence, then the cellular anti-oxidant system should play a large role in lifespan determination. Because superoxide dismutase (SOD) plays a central role in detoxifying superoxide radicals, we have examined the effects of mutational inactivation of each isoform of sod on normal lifespan and lifespan extension by dietary restriction (DR) or cold-/hypothermic-induced longevity (CHIL). We find no significant decrease in lifespan for control worms or worms undergoing DR when sod isoforms are knocked-out even though sod mutational inactivation produces hypersensitivity to paraquat. In contrast, sod-1 inactivation significantly reduces lifespan extension by CHIL, suggesting that CHIL requires a specific genetic program beyond simple reduction in metabolic rate. Furthermore, CHIL paradoxically increases lifespan while reducing resistance to oxidative stress, further disassociating oxidative stress resistance and lifespan.

  7. Serotonin Transporter-Linked Polymorphic Region (5-HTTLPR) Genotype and Stressful Life Events Interact to Predict Preschool-Onset Depression: A Replication and Developmental Extension

    Science.gov (United States)

    Bogdan, Ryan; Agrawal, Arpana; Gaffrey, Michael S.; Tillman, Rebecca; Luby, Joan L.

    2014-01-01

    Background: Scientific enthusiasm about gene × environment interactions, spurred by the 5-HTTLPR (serotonin transporter-linked polymorphic region) × SLEs (stressful life events) interaction predicting depression, have recently been tempered by sober realizations of small effects and meta-analyses reaching opposing conclusions. These mixed findings…

  8. Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting.

    Science.gov (United States)

    Meyer, Saskia; Nederend, Maaike; Jansen, J H Marco; Reiding, Karli R; Jacobino, Shamir R; Meeldijk, Jan; Bovenschen, Niels; Wuhrer, Manfred; Valerius, Thomas; Ubink, Ruud; Boross, Peter; Rouwendal, Gerard; Leusen, Jeanette H W

    2016-01-01

    Antibody therapy is a validated treatment approach for several malignancies. All currently clinically applied therapeutic antibodies (Abs) are of the IgG isotype. However, not all patients respond to this therapy and relapses can occur. IgA represents an alternative isotype for antibody therapy that engages FcαRI expressing myeloid effector cells, such as neutrophils and monocytes. IgA Abs have been shown to effectively kill tumor cells both in vitro and in vivo. However, due to the short half-life of IgA Abs in mice, daily injections are required to reach an effect comparable to IgG Abs. The relatively long half-life of IgG Abs and serum albumin arises from their capability of interacting with the neonatal Fc receptor (FcRn). As IgA Abs lack a binding site for FcRn, we generated IgA Abs with the variable regions of the Her2-specific Ab trastuzumab and attached an albumin-binding domain (ABD) to the heavy or light chain (HCABD/LCABD) to extend their serum half-life. These modified Abs were able to bind albumin from different species in vitro. Furthermore, tumor cell lysis of IgA-Her2-LCABD Abs in vitro was similar to unmodified IgA-Her2 Abs. Pharmacokinetic studies in mice revealed that the serum exposure and half-life of the modified IgA-Her2 Abs was extended. In a xenograft mouse model, the modified IgA1 Abs exhibited a slightly, but significantly, improved anti-tumor response compared to the unmodified Ab. In conclusion, empowering IgA Abs with albumin-binding capacity results in in vitro and in vivo functional Abs with an enhanced exposure and prolonged half-life.

  9. Pre-operative renal artery embolization and suprarenal IVC filter placement for prevention of fat embolization in renal angiomyolipoma with venous extension.

    Science.gov (United States)

    Cornman-Homonoff, Joshua; Li, David; Schiffman, Marc

    2017-01-26

    Though generally considered benign, angiomyolipomas can invade through the renal vein into the inferior vena cava, putting patients at risk of catastrophic pulmonary fat embolization. Venous invasion is thus an indication for surgical resection but is thought to increase the risk of adverse operative outcomes including intraoperative hemorrhage and embolization of fat and/or tumor thrombus. We report a novel approach to mitigating these complications illustrated in the case of a 43-year-old woman with IVC-invasive renal AML who underwent successful radical nephrectomy after concurrent pre-operative renal artery embolization and placement of a retrievable suprarenal IVC filter.

  10. Microbiological stabilization of tiger nuts' milk beverage using ultra-high pressure homogenization. A preliminary study on microbial shelf-life extension.

    Science.gov (United States)

    Codina-Torrella, I; Guamis, B; Zamora, A; Quevedo, J M; Trujillo, A J

    2018-02-01

    Tiger nuts' milk beverages are highly perishable products. For this reason, the interest of food industry for their commercialization makes necessary the application of preservation treatments to prolong their shelf-life. In the current study, the effect of ultra-high pressure homogenization (UHPH) on the microbiological and sensory qualities of tiger nuts' milk beverage was evaluated. Characteristics of UHPH-treated products (at 200 and 300 MPa, with inlet temperature of 40 °C) were compared with those of raw (RP) and conventionally homogenized-pasteurized (H-P) beverages, after treatment and during cold storage at 4 °C. Microbiological quality of beverages was studied by enumerating total counts, psychrotrophic bacteria, lactobacilli, enterobacteria, molds and yeasts, and mesophilic spores. Evolution of color and sensory characteristics of beverages were also determined. Microbiological shelf-life of the tiger nuts' milk beverages was extended from 3 to 25, 30 and 57 days by applying H-P and UHPH treatments at 200 and 300 MPa, respectively. Color of beverages was the only attribute that differentiated UHPH samples from the others, with greater luminosity and whiteness. Hence, UHPH treatments showed to be an alternative to the conventional H-P for obtaining tiger nuts' milk beverages with an improved microbiological shelf-life and good sensorial characteristics. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

    NARCIS (Netherlands)

    Sartipi, S.; Jansma, H.; Bosma, D.; Boshuizen, B.; Makkee, M.; Gascon, J.; Kapteijn, F.

    2013-01-01

    Design and operation of a “six-flow fixed-bed microreactor” setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controll

  12. A Proficiency Based Stepwise Endovascular Curricular Training (PROSPECT) Program Enhances Operative Performance in Real Life: A Randomised Controlled Trial.

    Science.gov (United States)

    Maertens, H; Aggarwal, R; Moreels, N; Vermassen, F; Van Herzeele, I

    2017-09-01

    Healthcare evolution requires optimisation of surgical training to provide safe patient care. Operating room performance after completion of proficiency based training in vascular surgery has not been investigated. A randomised controlled trial evaluated the impact of a Proficiency based Stepwise Endovascular Curricular Training program (PROSPECT) on the acquisition of endovascular skills and the transferability of these skills to real life interventions. All subjects performed two endovascular interventions treating patients with symptomatic iliac and/or superficial femoral artery stenosis under supervision. Primary outcomes were technical performances (Global Rating Scale [GRS]; Examiner Checklist), operative metrics, and patient outcomes, adjusted for case difficulty and trainee experience. Secondary outcomes included knowledge and technical performance after 6 weeks and 3 months. Thirty-two general surgical trainees were randomised into three groups. Besides traditional training, the first group (n = 11) received e-learning and simulation training (PROSPECT), the second group (n = 10) only had access to e-learning, while controls (n = 11) did not receive supplementary training. Twenty-nine trainees (3 dropouts) performed 58 procedures. Trainees who completed PROSPECT showed superior technical performance (GRS 39.36 ± 2.05; Checklist 63.51 ± 3.18) in real life with significantly fewer supervisor takeovers compared with trainees receiving e-learning alone (GRS 28.42 ± 2.15; p = .001; Checklist 53.63 ± 3.34; p = .027) or traditional education (GRS 23.09 ± 2.18; p = .001; Checklist 38.72 ± 3.38; p = .001). Supervisors felt more confident in allowing PROSPECT trained physicians to perform basic (p = .006) and complex (p = .003) procedures. No differences were detected in procedural parameters (such as fluoroscopy time, DAP, procedure time, etc.) or complications. Proficiency levels were maintained up to 3 months. A structured

  13. “Not Just an Apartment Building”: Residents’ Quality of Life in a Social Housing Co-operative

    Directory of Open Access Journals (Sweden)

    Angela Eileen Wisniewski

    2010-01-01

    Full Text Available The objective of this study was to examine the impact that two social housing complexes have had on their residents' quality of life. These two complexes, known as Tannery Court Co-operative Ltd., target a specific segment of the affordable housing market: non-elderly singles. A mixed-methods approach was used to assess the quality of life of residents. The data collection strategy used semi-structured interviews conducted with the help of a questionnaire. A total of 43 interviews were completed at the two building sites. Analysis of interview and questionnaire data identified six areas of improvement in residents' quality of life. These are life in general (an overarching dimension, housing (the focus of the Tannery Court intervention, neighbourhood (including safety and appearance, food, self-confidence (an enabling dimension for future development of projects and goals among the residents, and financial situation (a key dimension because of its multiple impacts on other aspects of life. / L'objectif de cette recherche était d'évaluer l'impact des deux complexes de logements coopératifs Tannery Court sur la qualité de vie des résidants. Ces complexes ciblent un segment particulier du marché du logement social, les célibataires d'âge actif et vivant en deçà du seuil de la pauvreté. Cette étude utilise une méthodologie mixte pour évaluer la situation et la qualité de vie des résidants. La stratégie de cueillette de données s'appuie sur des entrevues semi-dirigées effectuées à l'aide d'un questionnaire. Au total, nous avons complété 43 entrevues. Six aspects de la qualité de vie se sont améliorés de façon significative. Il s'agit de la vie en général (une dimension globale, le logement (l'objectif premier visé par l'équipe de Tannery Court, le quartier de résidence (dimensions importantes de la localisation d'un complexe comme la sécurité et l'apparence la confiance en soi (une dimension clé pour le d

  14. Progressive activation of degradation processes in solid oxide fuel cells stacks: Part I: Lifetime extension by optimisation of the operating conditions

    Science.gov (United States)

    Nakajo, Arata; Mueller, Fabian; Brouwer, Jacob; Van herle, Jan; Favrat, Daniel

    2012-10-01

    The degradation of solid oxide fuel cells (SOFC) depends on stack and system design and operation. A methodology to evaluate synergistically these aspects to achieve the lowest production cost of electricity has not yet been developed. A repeating unit model, with as degradation processes the decrease in ionic conductivity of the electrolyte, metallic interconnect corrosion, anode nickel particles coarsening and cathode chromium contamination, is used to investigate the impact of the operating conditions on the lifetime of an SOFC system. It predicts acceleration of the degradation due to the sequential activation of multiple processes. The requirements for the highest system efficiency at start and at long-term differ. Among the selected degradation processes, those on the cathode side here dominate. Simulations suggest that operation at lower system specific power and higher stack temperature can extend the lifetime by a factor up to 10, because the beneficial decrease in cathode overpotential prevails over the higher release of volatile chromium species, faster metallic interconnect corrosion and higher thermodynamic risks of zirconate formation, for maximum SRU temperature below 1150 K. The counter-flow configuration, combined with the beneficial effect of internal reforming on lowering the parasitic air blower consumption, similarly yields longer lifetime than co-flow.

  15. Six-flow operations for catalyst development in Fischer-Tropsch synthesis: bridging the gap between high-throughput experimentation and extensive product evaluation.

    Science.gov (United States)

    Sartipi, Sina; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge; Kapteijn, Freek

    2013-12-01

    Design and operation of a "six-flow fixed-bed microreactor" setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4 mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.

  16. Application of monolithic lining to tundish and extension of tundish life with improvement of refractories; Tandeisshu futeiseika to taikabutsu kaizen ni yoru jumyo kojo

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Eiichiro; Fujta, Takashi; Tanikawa, Kanji [Kobe Steel Corp., Hyogo (Japan)

    1999-06-01

    As a part of realization of monolithic liming of a tundish lining refractory, a study on 2CC and 3CC tundish monolithic refractories was carried out to improve placing efficiency and extend its life. Main inspection points were set on (1) casting facility specifications and (2) structure and material. A force feeding pump system with a high degree of freedom for placing layout was selected. It was judged preferable than a hopper dolly type ladle repair facility in the degree of freedom for a placing site and facility expenses, though little inferior at maintenance. A force feeding pump is combined with a boom to enable the facility to cast for plural objects. Low expansion and creep properties were given to the refractory by reviewing the addition of the expansive material and the structure was improved by setting anchor blocks at corner parts. The cost of refractories was reduced and labor saving of refractory placing workers was achieved by widely extending the life. (NEDO)

  17. Nuclear Weapons: NNSA Has a New Approach to Managing the B61-12 Life Extension, but a Constrained Schedule and Other Risks Remain

    Science.gov (United States)

    2016-02-01

    approaching the end of their operational lives, NNSA and DOD have underscored the importance of beginning production of the B61-12 in 2020 and...federal program office and federal program manager located at Kirtland Air Force Base in Albuquerque, New Mexico , which is also the site of NNSA’s...2019 2020 2020 W88 ALT 370 First Production Unit Dated Not discussed Not provided 2018e Not provided 2019 2020 2020 Cruise Missile

  18. Likelihood Algorithm of Linear Static Sensor Network Life Cycle Maximum Extension%线性静态传感网络生命周期极大似然延展算法

    Institute of Scientific and Technical Information of China (English)

    金海

    2015-01-01

    The linear static sensor network life cycle is affected by data fusion fault tolerance performance of the network, in order to improve the network life cycle, the need to improve the fault tolerance performance of network data fusion, improve data accuracy of reconstruction. The traditional method is using the sensor nodes in the sensor network credibility extension algorithm based on life cycle analysis, data redundancy cannot effectively remove the cluster head nodes, power consump-tion. A maximum likelihood estimation of life cycle extension algorithm for linear static sensor network based on the method is proposed. To construct the static sensor network linear model, set the number and position of the beacon node and inter node communication radius, data fusion, analyzes the redundancy of data fusion based on the maximum likelihood method, get the perturbation equation of linear sensor network life cycle extension, thus to realize the maximum likelihood algorithm improved life cycle extension. Simulation results show that the algorithm of data fusion quality is good, use fixed point itera-tion to speed up the convergence of the algorithm, greatly saving network energy and delay of the network life cycle.%线性静态传感网络的生命周期受到网络中数据融合容错性能的影响,为了提高网络的生命周期,需要提高网络数据融合的容错性能,提高数据重构精度.传统方法采用基于传感器节点信誉度集分析的传感网络生命周期延展算法,无法有效去除簇头节点的数据冗余,功耗较大.提出一种基于极大似然估计法的线性静态传感网络的生命周期延展算法.进行线性静态传感网络模型构建,设置信标节点的个数和位置以及节点间通信半径,进行数据融合处理,根据极大似然法进行数据融合的冗余性分析,得到线性传感网络的生命周期延展的扰动方程,由此实现了极大似然生命周期延展算法改进.仿真结果表

  19. Design, construction, and operation of a life-cycle test system for the evaluation of flue gas cleanup processes

    Energy Technology Data Exchange (ETDEWEB)

    Pennline, H.W.; Yeh, James T.; Hoffman, J.S. [USDOE Pittsburgh Energy Technology Center, PA (United States); Longton, E.J.; Vore, P.A.; Resnik, K.P.; Gromicko, F.N. [Gilbert/Commonwealth, Inc., Library, PA (United States)

    1995-12-01

    The Pittsburgh Energy Technology Center of the US Department of Energy has designed, constructed, and operated a Life-Cycle Test Systems (LCTS) that will be used primarily for the investigation of dry, regenerable sorbent flue gas cleanup processes. Sorbent continuously cycles from an absorber reactor where the pollutants are removed from the flue gas, to a regenerator reactor where the activity of the spent sorbent is restored and a usable by-product stream of gas is produced. The LCTS will initially be used to evaluate the Moving-Bed Copper Oxide Process by determining the effects of various process parameters on SO{sub 2} and NO{sub x} removals. The purpose of this paper is to document the design rationale and details, the reactor/component/instrument installation, and the initial performance of the system. Although the Moving-Bed Copper Oxide Process will be investigated initially, the design of the LCTS evolved to make the system a multipurpose, versatile research facility. Thus, the unit can be used to investigate various other processes for pollution abatement of SO{sub 2}, NO{sub x}, particulates, air toxics, and/or other pollutants.

  20. SMART marine goals, targets and management - Is SDG 14 operational or aspirational, is 'Life Below Water' sinking or swimming?

    Science.gov (United States)

    Cormier, Roland; Elliott, Michael

    2017-08-02

    The United Nations Sustainable Development Goals (SDG), adopted in September 2015, are accompanied by targets which have to be met individually and collectively by the signatory states. SDG14 Life Below Water aims to lay the foundation for the integrated and sustainable management of the oceans. However, any environmental management has to be based around targets which are SMART - specific, measurable, achievable, realistic and time bounded - otherwise it is not possible to determine whether management actions are successful and achieve the desired aims. The discussion here shows that many of the targets adopted for SDG14, and especially a detailed analysis of Target 1, are aspirational rather than fully quantified. In order to move towards making the targets operational, we advocate merging the language of environmental management with that used by industry for linking risks to the environment, management performance and ensuing controls. By adopting an approach which uses Key Performance Indicators ('KPIs'), Key Risk Indicators ('KRIs') and Key Control Indicators ('KCIs'), we advocate that a degree of rigour leading to defendable actions can be brought to marine management. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification.

    Directory of Open Access Journals (Sweden)

    Robert E White

    Full Text Available Epstein-Barr virus (EBV is able to drive the transformation of B-cells, resulting in the generation of lymphoblastoid cell lines (LCLs in vitro. EBV nuclear proteins EBNA3A and EBNA3C are necessary for efficient transformation, while EBNA3B is dispensable. We describe a transcriptome analysis of BL31 cells infected with a series of EBNA3-knockout EBVs, including one deleted for all three EBNA3 genes. Using Affymetrix Exon 1.0 ST microarrays analysed with the MMBGX algorithm, we have identified over 1000 genes whose regulation by EBV requires one of the EBNA3s. Remarkably, a third of the genes identified require more than one EBNA3 for their regulation, predominantly EBNA3C co-operating with either EBNA3B, EBNA3A or both. The microarray was validated by real-time PCR, while ChIP analysis of a selection of co-operatively repressed promoters indicates a role for polycomb group complexes. Targets include genes involved in apoptosis, cell migration and B-cell differentiation, and show a highly significant but subtle alteration in genes involved in mitosis. In order to assess the relevance of the BL31 system to LCLs, we analysed the transcriptome of a set of EBNA3B knockout (3BKO LCLs. Around a third of the genes whose expression level in LCLs was altered in the absence of EBNA3B were also altered in 3BKO-BL31 cell lines.Among these are TERT and TCL1A, implying that EBV-induced changes in the expression of these genes are not required for B-cell transformation. We also identify 26 genes that require both EBNA3A and EBNA3B for their regulation in LCLs. Together, this shows the complexity of the interaction between EBV and its host, whereby multiple EBNA3 proteins co-operate to modulate the behaviour of the host cell.

  2. Application of Multi-level Extensible Method to Urban Subway Operation Safety Evaluation%多级可拓评价方法在地铁运营安全评价中的应用

    Institute of Scientific and Technical Information of China (English)

    潘科; 王洪德; 石剑云

    2011-01-01

    根据地铁运营的特点及国家地铁建设法规及运营标准的要求,比较全面、系统地构建地铁运营安全评价指标体系.为了弥补现有地铁运营安全评价方法的不足,建立以可拓法为核心的地铁运营安全的多级可拓评价模型.并以北京地铁某线路为实例,确定该线路及其运营子系统的风险等级.针对评价结果提出预防地铁运营事故的有关对策,为我国地铁运营安全综合评价提供一种新的评价方法.理论分析和实例计算表明:该方法在地铁运营安全评价中有较好的适用性.该项工作可为我国地铁运营安全评价的深入研究提供参考.%The safety evaluation index system of subway operation is established on the basis of the characteristics of subway operation and the stipulations specified in the national subway construction and operation laws and regulations of our country. In order to make up for the deficiencies of the present subway operation safety evaluation method, the multi-level extensible evaluation model for subway operation safety is developed with the extension method as the core. One line of the Beijing Subway is studied as an example. The risk degrees of the line and its subsystems are determined. Countermeasures are proposed to prevent accidents in subway operation. A new method for comprehensive evaluation of subway operation safety in China is put forward. Theoretical analysis and case study indicate that the new method is applicable to subway operation safety evaluation and it provides reference in further deep research of subway operation safety evaluation in our country.

  3. FIELD TEST INSTRUCTION 100-NR-2 OPERABLE UNIT DESIGN OPTIMIZATION STUDY FOR SEQUESTRATION OF SR-90 SATURATED ZONE APATITE PERMEABLE REACTIVE BARRIER EXTENSION

    Energy Technology Data Exchange (ETDEWEB)

    BOWLES NA

    2010-10-06

    The objective of this field test instruction is to provide technical guidance for aqueous injection emplacement of an extension apatite permeable reactive barrier (PRE) for the sequestration of strontium-90 (Sr-90) using a high concentration amendment formulation. These field activities will be conducted according to the guidelines established in DOE/RL-2010-29, 100-NR-2 Design Optimization Study, hereafter referred to as the DOS. The DOS supports the Federal Facility Agreement Consent Order (EPA et al., 1989), Milestone M-16-06-01, and 'Complete Construction of a Permeable Reactive Barrier at 100-N.' Injections of apatite precursor chemicals will occur at an equal distance intervals on each end of the existing PRE to extend the PRB from the existing 91 m (300 ft) to at least 274 m (900 ft). Field testing at the 100-N Area Apatite Treatability Test Site, as depicted on Figure 1, shows that the barrier is categorized by two general hydrologic conceptual models based on overall well capacity and contrast between the Hanford and Ringold hydraulic conductivities. The upstream portion of the original barrier, shown on Figure 1, is characterized by relatively low overall well specific capacity. This is estimated from well development data and a lower contrast in hydraulic conductivity between the Hanford formation and Ringold Formations. Comparison of test results from these two locations indicate that permeability contrast between the Hanford formation and Ringold Formation is significantly less over the upstream one-third of the barrier. The estimated hydraulic conductivity for the Hanford formation and Ringold Formation over the upstream portion of the barrier based on observations during emplacement of the existing 91 m (300 ft) PRB is approximately 12 and 10 m/day (39 and 32 ft/day), respectively (PNNL-17429). However, these estimates should be used as a rough guideline only, as significant variability in hydraulic conductivity is likely to be observed in

  4. Research on Life Determination and Extension of Missile Weapon System Based on Multilevel Finite Element%基于多级有限元方法的导弹武器定寿延寿研究

    Institute of Scientific and Technical Information of China (English)

    常新龙; 张有宏; 岳春国; 余堰峰; 刘万雷

    2011-01-01

    提出了多级有限元的概念,将导弹结构定寿延寿工作划分为3个有限元分析步骤进行,在有限元分析的过程中考虑了导弹结构原始状态、老化缺陷状态及修理/换件的影响,对导弹结构强度及剩余寿命进行了科学准确的评判.利用该理论对含有老化和裂纹等损伤因素的药柱结构质量状态和对出现的裂纹损伤进行修复的效果进行了评价.结果表明,该方法科学合理,可为导弹武器系统定寿延寿工作提供一定的理论参考.%The concept of multilevel finite element was presented. The life determination and extension of missile structure was divided to three finite element analysis steps. In the finite element analysis, the influence of original state, weathering state, and repair or replacement of missile structure was considered. The structural strength and residual life of missile structure was estimated exactly. Using this method, the quality state of grain considering factors such as aging and crack damage and the effect of repair for crack damage were evaluated. The results showed that this method is scientific and can provide a reference for life determination and extension of missile weapon system.

  5. Vase Life Extension and Chlorophyll Fluorescence Yield of Bougainvillea Flower as Influenced by Ethanol to Attain Maximum Environmental Beautification as Ornamental Components

    Directory of Open Access Journals (Sweden)

    A. B.M. Hossain

    2008-01-01

    Full Text Available The study was conducted to investigate the effect of ethanol at different concentrations (ET on bougainvillea flower longevity and delay senescence in storage condition. The treatments were water control, 2% ET, 4% ET, 8% ET, 10% ET, 20% ET, 30% ET, 40% ET, 50% ET and 70% ET. Flower longevity was 2 days more in 4, 8% and 10% ethanol than water control and other concentrations of ethanol. Petal wilting and senescence were occurred 2 days later in 4, 8 and 10% ET than in water control. Percent petal's color changed was later in water 4, 8% and 10% than in control, 2, 20, 30, 40, 50 and 70% ET. Chlorophyll fluorescence intensity (photosynthetic yield followed by time (ms at different ethanol concentrations was higher in 4, 8 and 10% ET than in water control and other concentrations. Fo (lower fluorescence was lower in 4, 8 and 10% ET than in water and other concentrations. However, Fm and Fv [(higher fluorescence and relative variable fluorescence (Fm-Fo] were higher in 4, 8 and 10% ET than in other ET concentrations. Fv/Fm (quantum yield or photosynthetic yield was higher in 4, 8 and 10% ET than in other ET concentrations. The result showed flower vase life was significantly affected by ethanol concentrations and longevity was higher in 4, 8 and 10% ethanol than in water control and other concentrations.

  6. Studies and research concerning BNFP: life of project operating expenses for away-from-reactor (AFR) spent fuel storage facility. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Shallo, F. A.

    1979-09-01

    Life of Project operating expenses for a licensed Away-From-Reactor (AFR) Spent Fuel Storage Facility are developed in this report. A comprehensive business management structure is established and the functions and responsibilities for the facility organization are described. Contractual provisions for spent fuel storage services are evaluated.

  7. Extensions of WC-OWA operator and their applications in risk multi-attribute decision making%WC-OWA算子的拓展及其在风险型多属性决策中的应用

    Institute of Scientific and Technical Information of China (English)

    陈春芳; 朱传喜; 余克弟

    2011-01-01

    The extensions of the weighted C-OWA (WC-OWA) operators ware investigated. Some new aggregation operators and the properties of them were obtained. Futhernore.it proposd an approach to solve risk multi-attribute decision making,in which the attribute values were interval numbers. Finally,an illustrative example was illustrated to show the feasibility of the approach.%研究WC-OWA算子的拓展形式,得到了一些新的数据集成算子,并对其性质进行了研究.在此基础上,探讨属性值以区间形式给出的风险型多属性决策的方法,并用实例进行分析说明该方法的可行性.

  8. Multilayer Multidimensional Extension Set Theory

    Institute of Scientific and Technical Information of China (English)

    CAO Shao-zhong; YANG Guo-wei; TU Xu-yan

    2006-01-01

    In order to study the contradiction problem of multilayer multidimensional complex systems, the concepts of extension field and stable field of intersection and union of multilayer multidimensional extension set are given. Then the related operations and properties are discussed. The results of study expand the concepts of intersection and union of extension set to a general situation, and provide the theoretical basis for production of the concepts of intersection and union of multilayer multidimensional matter element system extension set. In this way, it will be possible that matter element system theory is used to creative designs of complex systems.

  9. Ultraviolet Extensions

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Side-by-Side Comparison Click on image for larger view This ultraviolet image from NASA's Galaxy Evolution Explorer shows the Southern Pinwheel galaxy, also know as Messier 83 or M83. It is located 15 million light-years away in the southern constellation Hydra. Ultraviolet light traces young populations of stars; in this image, young stars can be seen way beyond the main spiral disk of M83 up to 140,000 light-years from its center. Could life exist around one of these far-flung stars? Scientists say it's unlikely because the outlying regions of a galaxy are lacking in the metals required for planets to form. The image was taken at scheduled intervals between March 15 and May 20, 2007. It is one of the longest-exposure, or deepest, images ever taken of a nearby galaxy in ultraviolet light. Near-ultraviolet light (or longer-wavelength ultraviolet light) is colored yellow, and far-ultraviolet light is blue. What Lies Beyond the Edge of a Galaxy The side-by-side comparison shows the Southern Pinwheel galaxy, or M83, as seen in ultraviolet light (right) and at both ultraviolet and radio wavelengths (left). While the radio data highlight the galaxy's long, octopus-like arms stretching far beyond its main spiral disk (red), the ultraviolet data reveal clusters of baby stars (blue) within the extended arms. The ultraviolet image was taken by NASA's Galaxy Evolution Explorer between March 15 and May 20, 2007, at scheduled intervals. Back in 2005, the telescope first photographed M83 over a shorter period of time. That picture was the first to reveal far-flung baby stars forming up to 63,000 light-years from the edge of the main spiral disk. This came as a surprise to astronomers because a galaxy's outer territory typically lacks high densities of star-forming materials. The newest picture of M83 from the Galaxy Evolution Explorer is shown at the right, and was taken over a longer period of time. In fact, it is one of the

  10. An operational method for the evaluation of resource use and environmental impacts of dairy farms by life cycle assessment.

    Science.gov (United States)

    van der Werf, Hayo M G; Kanyarushoki, Claver; Corson, Michael S

    2009-08-01

    This paper describes and applies EDEN-E, an operational method for the environmental evaluation of dairy farms based on the life cycle assessment (LCA) conceptual framework. EDEN-E requires a modest amount of data readily available on-farm, and thus can be used to assess a large number of farms at a reasonable cost. EDEN-E estimates farm resource use and pollutant emissions mostly at the farm scale, based on-farm-gate balances, amongst others. Resource use and emissions are interpreted in terms of potential impacts: eutrophication, acidification, climate change, terrestrial toxicity, non-renewable energy use and land occupation. The method distinguishes for each total impact a direct component (impacts on the farm site) and an indirect component (impacts associated with production and supply of inputs used). A group of 47 dairy farms (41 conventional and six organic) was evaluated. Expressed per 1000kg of fat-and-protein-corrected milk, total land occupation was significantly larger for organic than for conventional farms, while total impacts for eutrophication, acidification, climate change, terrestrial toxicity, and non-renewable energy use were not significantly different for the two production modes. When expressed per ha of land occupied all total impacts were significantly larger for conventional than organic farms. This study largely confirms previously published findings concerning the effect of production mode on impacts of dairy farms. However, it strikingly reveals that, for the set of farms examined, the contribution of production mode to overall inter-farm variability of impacts was minor relative to inter-farm variability within each of the two production modes examined. The mapping of impact variability through EDEN-E opens promising perspectives to move towards sustainable farming systems by identifying the structural and management characteristics of the farms presenting the lowest impacts.

  11. Strategy for Spacecraft Performance and Mission Extension

    Science.gov (United States)

    Canela, M.; Vogel, P.; Lorza-Pitt, R.; Duesmann, B.

    2010-12-01

    The preservation of the In-Orbit performance of the ESA Earth Observation Satellites and the extension of their operational life as long as possible (or as necessary) is one of the main roles of the Post Launch Support Office (PLSO). In most of the cases, innovative ideas and developments adapted to each particular situation have to be implemented. Specific methods, tools and procedures have been put into practice, but close collaboration with the flight operation and product quality teams, together with the support from the ESA experts and industry is the key of the success. The excellent performance of ERS and ENVISAT are the result of the effort of all the engineers involved in these objectives.

  12. Factors influencing the departure of South African advanced life support paramedics from pre-hospital operational practice

    Directory of Open Access Journals (Sweden)

    Stuart Hackland

    2011-06-01

    Conclusion: Whilst the job of an ALS paramedic is difficult and demanding, it was not operational factors that appeared to cause the majority of ALS paramedics to leave operational practice, but rather organisational and career-based factors. These factors should be addressed in order to improve job satisfaction, with the objective of retaining more operational paramedics for longer.

  13. Standard Operating Procedure for Using the NAFTA Guidance to Calculate Representative Half-life Values and Characterizing Pesticide Degradation

    Science.gov (United States)

    Results of the degradation kinetics project and describes a general approach for calculating and selecting representative half-life values from soil and aquatic transformation studies for risk assessment and exposure modeling purposes.

  14. Analysis of Extension Categorical Data Mining Process for the Extension Interior Designing

    Institute of Scientific and Technical Information of China (English)

    Hui Ma; Guangtian Zou

    2016-01-01

    On the basis of extension architectonics, this paper researches the process of extension categorical data mining for extension interior design. In accordance with the theory of extension data mining, the extension categorical data mining for the extension interior design can be divided into data preparation, the operation of mining and knowledge application. The paper expatiates the main content and cohesive relations of each link, and emphatically discusses extension acquisition, analysis extension, categorical mining extension, knowledge application extension and other several core nodes that are related with data. Through the knowledge fusion of extension architectonics and data mining, the paper discusses the process of knowledge requirements with multiple classification under different mining targets. The purpose of this paper is to explore a whole categorical data mining process of interior design from extension design data to the design of knowledge discovery and extension application.

  15. Life assessment of gas turbine blades after long term service

    Energy Technology Data Exchange (ETDEWEB)

    Auerkari, Pertti; Salonen, Jorma [VTT, Espoo (Finland); Maekinen, Sari [Helsingin Energia, Helsinki (Finland); Karvonen, Ikka; Tanttari, Heikki [Lappeenrannan Laempoevoima, Lappeenranta (Finland); Kangas, Pekka [Neste Oil, Kilpilahti (Finland); Scholz, Alfred [Technische Univ. Darmstadt (Germany); Vacchieri, Erica [Ansaldo Richerche, Genoa (Italy)

    2010-07-01

    Turbine blade samples from three land based gas turbines have been subjected to systematic condition and life assessment after long term service (88000 - 109000 equivalent operating hours, eoh), when approaching the nominal or suggested life limits. The blades represent different machine types, materials and design generations, and uncooled blading outside the hottest front end of the turbine, i.e. blades with relatively large size and considerable expected life. For a reasonable assessment, a range of damage mechanisms need to be addressed and evaluated for the impact in the residual life. The results suggested significant additional safe life for all three blade sets. In some cases this could warrant yet another life cycle comparable to that of new blades, even after approaching the nominal end of life in terms of recommended equivalent operating hours. This is thought to be partly because of base load combined cycle operation and natural gas fuel, or modest operational loading if the design also accounted for more intensive cycling operation and more corrosive oil firing. In any case, long term life extension is only appropriate if not intervened by events of overloading, overheating or other sudden events such as foreign object damage (FOD), and if supported by the regular inspection and maintenance program to control in-service damage. Condition based assessment therefore remains an important part of the blade life management after the decision of accepted life extension. (orig.)

  16. Least cost options for life extension

    Energy Technology Data Exchange (ETDEWEB)

    Davis, F.; Bradaric, M. [Bechtel Corp., San Francisco, CA (United States)

    1995-12-01

    Rehabilitation of existing electric generating capacity offers one of the most cost-effective ways of meeting near-term power needs in many Eastern and Central European countries. In particular, the uncertainty associated with other supply sources and severe capital constraints tends to favor investments which maximize the utilization of existing fossil-fired equipment. However, it is critical that least-cost planning principles, including the consideration of environmental impacts, be applied to the economic analysis of rehabilitation options. This paper draws on Bechtel`s experience in applying least-cost planning to plant rehabilitation studies in Bulgaria, Romania and Slovakia. The examples provided illustrate the importance of least-cost planning and the effect of the value placed on environmental emissions.

  17. On Nilpotent Extensions of Algebras

    Institute of Scientific and Technical Information of China (English)

    Adam W. Marczak; Jerzy Plonka

    2007-01-01

    In this paper, we investigate essentially n-ary term operations of nilpotent extensions of algebras. We detect the connection between term operations of an original algebra and its nilpotent extensions. This structural point of view easily leads to the conclusion that the number of distinct essentially n-ary term operations of a proper algebraic nilpotent extension (ひ) of an algebra (ワ) is given by the formula pn(ひ)={pn(ワ)+1 for n=1,{pn(ワ) otherwise. We show that in general the converse theorem is not true. However, we suppose that if a variety V is uniquely determined by its pn-sequences, the converse theorem is also satisfied. In the second part of the paper, we characterize generics of nilpotent shifts of varieties and describe cardinalities of minimal generics. We give a number of examples and pose some problems.

  18. A 205 Hour Krypton Propellant Life Test of the SPT-100 Operating at 3 kW

    Science.gov (United States)

    2013-09-01

    Ballistic Missile Defense Organization (BMDO) led efforts to transfer SPT technology to the United States so that western spacecraft could benefit from their...the performance of the SPT-100 operating on krypton was characterized using an inverted pendulum thrust stand over a wide range of thruster operating

  19. 胃癌术后患者生活质量研究%STUDY OF QUALITY OF LIFE IN PATIENTS WITH GASTRIC CANCER AFTER OPERATION

    Institute of Scientific and Technical Information of China (English)

    李文英; 曹淑红; 张晓峰; 庞艳玲; 宋春惠; 闫继霞

    2011-01-01

    [目的]调查胃癌术后患者生活质量(QOL),探讨影响QOL的相关因素.[方法]用胃癌患者生活质量问卷(QLQ-STO22)和生活质量核心问卷(QLQ-C30)组合问卷对116例胃癌术后1年的患者(胃癌组)进行调查,选择同期行胃部手术的非胃癌患者50例作为对照. [结果] (1)胃癌组生活质量评分高于对照组. (2)单因素比较显示QOL在不同年龄、家庭收入、营养锻炼、定期复查保健、职业性质、UICC-TNM分期、手术方式、根治度、联合脏器切除和术后化疗方面存在差异,P< 0.05. (3)多因素Logistic回归进入主效应模型的变量是:年龄,营养锻炼,定期复查保健,手术方式、根治度、联合脏器切除和术后化疗.[结论]胃癌术后患者的QOL较差,年龄、手术方式、根治度、联合脏器切除、术后化疗、营养锻炼和定期复查是影响QOL的强相关因素.%[Objective] To investigate the quality of life (QOL) and the main influencing factors in patients with gastric cancer after operation. [Methods] 116 patients with gastric cancer (gastric cancer group) were investigated by using Quality of life Questionnaire of Stomach 22 (QLQ-STO22) and Quality of life Core Questionnaire (QLQ-C30) in one years after operation, and control group was 50 gastric operation cases without gastric cancer. [ Results] ( 1) The gastric cancer group score of quality of life were higher than those of control group. (2) Univariate analysis indicated that quality of life was related to age, family income, pay attention to nutrition and physical exercise, regular re-examination and care, job, UICC-TNM stage, operation method, extent of tumor resection, combined multiple organ resection and postoperative chemotherapy (P < 0.05). (3) Age, nutrition and physical exercise, regular re-examination and care, operation method, extent of tumor resection, combined multiple organ resection and postoperative chemotherapy entered multivariate logistic regression

  20. Remaining Life Analysis of Boiler Tubes on Behalf of Hoop Stresses Produced During Operation of Power Plant

    Directory of Open Access Journals (Sweden)

    Mohd. Zeeshan Gauri

    2014-07-01

    Full Text Available Boiler tube material plays an important role in efficient power generation from a fossil fuel power plant. In order to meet out the gap between fluids to increase heat available per unit mass flow of steam. Waste heat utilization phenomenon is a big challenge on fossil fuel power plants as after use of high grade coal in thermal power plants the efficiency of power plants is not at the level of required value. Clean and efficient power generation with economical aspects is the basic need of growing power generation plants to justify the quality of power and clean power generation. Life analysis technique to calculate remaining life of boiler tubes at critical zones of high temperature requires much attention and is an important hypothesis in research field. Generation of repetitive and fluctuating stress during flow of high temperature and pressure fluid require proper attention on the methodology to be used to calculate the efficiency of system and absorption efficiency of tube material. In this paper complete mathematical analysis of boiler tubes is conducted for calculation of remaining life of boiler tubes, Hoop stress values are calculated and used with mathematical tool to calculate the efficiency. Hoop stress based calculation of efficiency is more reliable and may give more accurate and practical aspects based results.

  1. Potential relevance of pre-operative quality of life questionnaires to identify candidates for surgical treatment of genital prolapse: a pilot study

    Directory of Open Access Journals (Sweden)

    Chauvin Christian

    2012-03-01

    Full Text Available Abstract Background To evaluate prolapse-related symptoms, quality of life and sexuality of patients with validated questionnaires before and after surgery for genital prolapse and assess relevance of such an evaluation to select women for surgery. Methods From November 2009 to April 2010, 16 patients operated on for genital prolapse of grade greater than or equal to 2 (POP-Q classification were evaluated prospectively by three questionnaires of quality of life Pelvic Floor Distress Inventory (PFDI-20, Pelvic Floor Impact Questionnaire (PFIQ-7 and Pelvic Organ Prolaps/Urinary Incontinence Sexual Questionnaire (PISQ-12. Data were collected the day before surgery and 6 weeks postoperatively. Results Eleven patients had laparoscopic surgery and five vaginal surgery. There was a significant decrease in pelvic heaviness, vaginal discomfort and urinary symptoms after surgery. The score of symptoms of prolapse, the PFDI-20 score was 98.5 preoperatively and 31.8 postoperatively (p Conclusions This study suggests that surgery improves quality of life of patients with genital prolapse. Quality of life questionnaires could help select good candidates for surgery. Further studies are required to determine threshold to standardize indications of surgery.

  2. Studies and development of essential systems in the surveillance program, life extension potential of the vessel and master curve in nuclear power plants; Estudios y desarrollo de sistemas necesarios en el programa de vigilancia, potencial extension de vida de la vasija y curva maestra en nucleoelectricas

    Energy Technology Data Exchange (ETDEWEB)

    Romero C, J.; Hernandez C, R.; Rocamontes A, M.; Perez R, N., E-mail: jesus.romero@inin.gob.m [ININ, Departamento de Automatizacion e Instrumentacion, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-07-01

    The nuclear power plants owners should demonstrate that the effects of the embrittlement by neutronic radiation do not commit the structural integrity of the pressure vessel of the nuclear reactors, so much under conditions of routine operation as below an accident postulate. In consequence, in Mexico surveillance programs of the vessels of the nuclear power plant of Laguna Verde exist, in which three surveillance capsules are have by reactor. A surveillance capsule is composed by a support and between six and eight containers for test tubes and dosemeters. The containers for test tubes are of two types: rectangular container for Charpy V test tubes and cylindrical container for tension test tubes. These test tubes are subject to a same or bigger neutronic flow that of the vessel, being representative witness of the mechanical conditions of the vessel. The objective of to assay the test tubes to impact is to evaluate the embrittlement grade of the vessel beforehand during its useful life of operation, as well as to determinate the running of the ductile-fragile transition temperature in function of the time. (Author)

  3. An application of modulated poisson processes to aging evaluation for the extension of qualified life of nuclear power plant equipment; Uma aplicacao de processos pontuais modulados a avaliacao do envelhecimento para a extensao da vida qualificada de equipamentos de centrais nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Saldanha, Pedro Luiz da Cruz

    2003-03-01

    The modulated power law process (MPLP) is a three-parameter stochastic point process model that can be used to describe the failures time of reparable systems. While the power law process implies that a system is exactly on the same condition just after a repair as just before a failure, the MPLP allows for the system to be affected both by failure and repair. For this reason this model is adequate for evaluating the recurrent events that incorporate both time trends and effects of past events such as the renewal type behavior. The purpose of this study is to evaluate the MPLP as a model for the rate of occurrence of failures of a repairable system to decide for an extension of qualified life in the context of licence renewal of a nuclear power plant. Standard statistical techniques, such as the maximum likelihood and linear regression models, are applied to estimate parameters of the MPLP. As a conclusion of the study, the MPLP is adequate for modelling rate of occurrence of failures that are time dependent, and can be used where the aging mechanisms are present in the operation of repairable systems. (author)

  4. Enhanced Life Prediction Technology for Engine Rotor Life Extension (ERLE)

    Science.gov (United States)

    2008-09-01

    Enright , R. Craig McClung, Luc J. Huyse, Harry Millwater, Tom Conquest, Ana Del Amo, and Simeon Fitch Southwest Research Institute SEPTEMBER... ROBERT MARSHALL, Deputy Division Chief Metals, Ceramics, and NDE Division Materials and Manufacturing...ELEMENT NUMBER 62102F 6. AUTHOR(S) Stephen J. Hudak, Jr., Michael P. Enright , R. Craig McClung, and Luc J. Huyse (Southwest Research

  5. 镇江市征润州污水处理厂改扩建工程设计与运行%Design and operation of reconstruction and extension project of Zhengrunzhou Wastewater Treatment Plant in Zhenjiang City

    Institute of Scientific and Technical Information of China (English)

    袁绍春; 张智; 王敏; 胡坚; 赵冀平; 陈滨; 喻一萍

    2011-01-01

    Modified oxidation pond was applied to the second stage reconstruction and extension project of Zhengrunzhou Wastewater Treatment Plant in Zhenjiang City. Design scale of second-phase project was 5. 5×104 m3/d and the capacity of CAST could catch up to 1. 25×105 m3/d by setting regulating pond. There existed two combinations of pond system and CAST system: parallel operation to increase capacity in recent period, serial operation to improve the treatment efficiency in long-term. Diving aeration was recommended for aerated pond and biological pond. The bottom sludge and residual sludge were discharged into film constructed filter drying bed. The operation data showed that average pollutants removal rate of pond system was above 70% and the effluent quality met the standards. This paper introduced the treatment process, design parameters, equipments and investment, and the design characteristics were also summarized.%镇江市征润州污水处理厂二期改扩建工程规模为5.5万m3/d,采用改良型氧化塘工艺,同时设置调节塘使原CAST系统处理水量达到12.5万m3/d.塘系统与CAST系统可形成两种组合:近期并联运行扩容,远期串联运行提标.曝气塘和生物塘采用潜水曝气方式,底泥和剩余污泥排入覆膜人工滤层干化床.运行数据表明,塘系统对各污染物的平均去除率均在70%以上,出水水质达标.介绍了工艺流程、设计参数、设备配置情况及项目投资,并总结了设计特点.

  6. The BGAN extension programme

    Science.gov (United States)

    Rivera, Juan J.; Trachtman, Eyal; Richharia, Madhavendra

    2005-11-01

    Mobile satellite telecommunications systems have undergone an enormous evolution in the last decades, with the interest in having advanced telecommunications services available on demand, anywhere and at any time, leading to incredible advances. The demand for braodband data is therefore rapidly gathering pace, but current solutions are finding it increasingly difficult to combine large bandwidth with ubiquitous coverage, reliability and portability. The BGAN (Broadband Global Area Network) system, designed to operate with the Inmarsat-4 satellites, provides breakthrough services that meet all of these requirements. It will enable broadband connection on the move, delivering all the key tools of the modern office. Recognising the great impact that Inmarsat's BGAN system will have on the European satellite communications industry, and the benefits that it will bring to a wide range of European industries, in 2003 ESA initiated the "BGAN Extension" project. Its primary goals are to provide the full range of BGAN services to truly mobile platforms, operating in aeronautical, vehicular and maritime environments, and to introduce a multicast service capability. The project is supported by the ARTES Programme which establishes a collaboration agreement between ESA, Inmarsat and a group of key industrial and academic institutions which includes EMS, Logica, Nera and the University of Surrey (UK).

  7. A Global Strategy to Clear the "Space Protected Zones" from the Spacecrafts, at their End of Operative Life

    Science.gov (United States)

    Balduccini, M.; Portelli, C.

    2009-03-01

    The increasing number of orbiting spacecrafts is "pushing-up" the problem of controlling the risk of collision with orbital debris. Several European Space Agencies (ASI, BNSC, CNES, DLR and ESA) recently decided to adopt a common "European Code of Conduct for Space Debris Mitigation". This paper focuses on the Code Requirement relevant to clear the space volume around Geosyncronous Earth Orbit (GEO) at the satellite end of life, as well as the one that imposes a maximum residual orbital life of 25 years to defunct Spacecrafts (S/C) orbiting up to 2000 Km of altitude. The optimal technical solution to meet such requirements is significantly different basing on mission and S/C characteristics, namely the orbit altitude, the S/C dimensions and ballistic coefficient, the dry mass, the on board propulsion type. This paper intends to help the S/C designers to identify the most promising technical solutions that guarantee the compliance with the Space Debris Mitigation Code requirements, and minimise the impact on their S/C. After an introduction, where the Code Requirements are recalled and commented, the paper defines the orbit altitude ranges for which an homogeneous debris control strategy can be efficiently developed. Then, the core part of the paper is constituted by the analysis of each orbital ranges above, and to the consequent definition of the most promising approach for clearing the orbit after the End Of Service (EOS). Such approaches include: a)"do nothing" where Code Requirements will be met by any S/C original design, b) utilise aero-brakes to accelerate the natural de-orbiting, c) utilise a propulsion module to de-orbit from Low Earth Orbit (LEO) or, d) to increase orbital altitude above the LEO protected one, e) utilise the S/C own propulsion to perform the graveyard firing of GEO satellites, supported by the use of an accurate, and reliable, residual propellant gauging system that assures the availability of the propellant for the manoeuvre. In addition

  8. Breathing exercises improve post-operative pulmonary function and quality of life in patients with lung cancer: A meta-analysis.

    Science.gov (United States)

    Liu, Wei; Pan, Ying-Li; Gao, Cai-Xiang; Shang, Zuo; Ning, Li-Juan; Liu, Xing

    2013-04-01

    Previous research has shown that breathing exercises may improve the prognosis and health status in patients with lung cancer by enhancing pulmonary function and quality of life (QOL). However, individually published results are inconclusive. The aim of the present meta-analysis was to evaluate the clinical value of breathing exercises on post-operative pulmonary function and QOL in patients with lung cancer. A literature search of Pubmed, Embase, the Web of Science and CBM databases was conducted from their inception through to October 2012. Crude standardized mean differences (SMDs) with 95% confidence intervals (CIs) were used to assess the effect of breathing exercises. A total of eight clinical studies were ultimately included with 398 lung cancer patients. When all the eligible studies were pooled into the meta-analysis, there was a significant difference between the pre-intervention and post-intervention results of breathing exercises on post-operative pulmonary function; forced expiratory volume in 1 sec (FEV1): SMD, 3.37; 95% CI, 1.97-4.77; Pintervention with breathing exercises; there were significant differences between the pre-intervention and post-intervention results on the ability of self-care in daily life (SMD, -1.00; 95% CI, -1.467 to -0.52; P<0.001), social activities (SMD, -0.94; 95% CI, -1.73 to -0.15; P=0.02), symptoms of depression (SMD, -0.91; 95% CI, -1.25 to -0.57; P<0.001) and symptoms of anxiety (SMD, -0.91; 95% CI, -1.20 to -0.63; P<0.001). Results from the present meta-analysis suggest that breathing exercises may significantly improve post-operative pulmonary function and QOL in patients with lung cancer.

  9. Definition of the minimum longitude of insert in the rebuilding of Charpy test tubes for surveillance and life extension of vessels in Mexico; Definicion de la longitud minima de inserto en la reconstitucion de probetas Charpy para vigilancia y extension de vida de vasijas en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Romero C, J.; Hernandez C, R.; Rocamontes A, M., E-mail: jesus.romero@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2011-11-15

    In the National Institute of Nuclear Research (Mexico) a welding system for the rebuilding of Charpy test tubes has been developed, automated, qualified and used for the surveillance of the mechanical properties (mainly embrittlement) of the vessel. This system uses the halves of the rehearsed Charpy test tubes of the surveillance capsules extracted of the reactors, to obtain, of a rehearsed test tube, two reconstituted test tubes. This rebuilding process is used so much in the surveillance program like in the potential extension of the operation license of the vessel. To the halves of Charpy test tubes that have been removed the deformed part by machine are called -insert- and in a very general way the rebuilding consists in weld with the welding process -Stud Welding- two metallic implants in the ends of the insert, to obtain a reconstituted test tube. The main characteristic of this welding are the achieved small dimensions, so much of the areas welded as of the areas affected by the heat. The applicable normative settles down that the minim longitude of the insert for the welding process by Stud Welding it should be of 18 mm, however according to the same normative this longitude can diminish if is demonstrated analytic or experimentally that the central volume of 1 cm{sup 3} in the insert is not affected. In this work the measurement of the temperature profiles to different distances of the welding interface is presented, defining an equation for the maximum temperatures reached in function of the distance, on the other hand the real longitude affected in the test tube by means of metallography is determined and this way the minimum longitude of the insert for this developed rebuilding system was determined. (Author)

  10. Journal of Agricultural Extension

    African Journals Online (AJOL)

    Mission Statement The mission of the "Journal of Agricultural Extension" is to publish ... diffusion and adoption of innovations; extension communication models and ... Socio-Economic Determinants of Cocoyam Farmer's Strategies for Climate ...

  11. Cycle-life testing of 100-Ah class lithium-ion battery in a simulated geosynchronous-Earth-orbit satellite operation

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xianming; Sone, Yoshitsugu; Naito, Hitoshi; Yamada, Chisa; Segami, Go; Kibe, Koichi [Institute of Aerospace Technology, Japan Aerospace Exploration Agency, Tsukuba Space Center, Sengen 2-1-1, Ibaraki 305-8505 (Japan)

    2006-09-29

    In this paper, we review our work on cycle-life testing of a 100-Ah class lithium-ion battery in a simulated geosynchronous-Earth-orbit (GEO) satellite operation. The battery consists of ten 100-Ah lithium-ion (10) cells in a series, with a high energy density exceeding 100Whkg{sup -1} at the battery level. We simulate the eclipse period in real-time testing with five depth-of-discharge (DOD) patterns at an ambient temperature of 15{sup o}C. We also simulate a sun-shine period in 8-day thermally accelerated full-charge storage at an ambient temperature of 25{sup o}C, which in our experience corresponds to full-charge storage of a half-year operation at 0{sup o}C. Eighteen eclipse seasons have presently been completed, corresponding to 9 years of GEO operation. The battery maintained a high voltage near 3.4V at the end of the discharge, even when the DOD was set at 70%. The voltage dispersion of 10 cells was also sufficiently small in the range of 48mV. The cell temperature reached a maximum of 29{sup o}C and maintained minimal dispersion smaller than 4{sup o}C even when the battery was discharged at a high DOD of 70%. (author)

  12. EXTENSIVE NECROTIZING FASCIITIS OF TRUNK FOLLOWING APPENDICECTOMY

    Directory of Open Access Journals (Sweden)

    Siddharth

    2015-03-01

    Full Text Available Acute appendicitis is usually diagnosed and managed easily with a low mortality and morbidity. However, in 20.74% patients, acute appendicitis may occasionally become extraordinarily complicated and life threatening with significant morbidity and mortality . [1] We report a case of 44 year old male, a known case of Diabetes Mellitus since 4 years (on irregular treatment who was brought to our hospital with severe pain in right lower quadrant of abdomen since 4 days. On examination, patient had tachycardia, tender ness and guarding in the right iliac fossa. Laboratory results revealed leucocytosis and raised blood glucose levels. Measures for glycemic control were initiated. At exploratory laparotomy, an inflamed and retrocaecal appendix ruptured at the base with sm all local abscess was found. Abscess was drained and appendectomy done. Initially patient did well but at the end of second post - operative week, the patient started having pain and swelling over posterior chest wall, flank, sacral and occipital regions sug gestive of inflammation. CT abdomen and pelvis showed extensive necrotizing fasciitis of trunk, occiput and sacrum. Repeated multiple fasciotomies were performed over the back. The patient finally recovered fully at the end of 8 th post - operative week

  13. CANONICAL EXTENSIONS OF SYMMETRIC LINEAR RELATIONS

    NARCIS (Netherlands)

    Sandovici, Adrian; Davidson, KR; Gaspar, D; Stratila, S; Timotin, D; Vasilescu, FH

    2006-01-01

    The concept of canonical extension of Hermitian operators has been recently introduced by A. Kuzhel. This paper deals with a generalization of this notion to the case of symmetric linear relations. Namely, canonical regular extensions of symmetric linear relations in Hilbert spaces are studied. The

  14. Operating Mode of Low Carbon Buildings in Full Life Cycle%低碳建筑全寿命周期内的运行模式研究

    Institute of Scientific and Technical Information of China (English)

    李瑞; 贾广征

    2011-01-01

    At present, low-carbon building market is lack of effective support of policy, economy, technology and so on in China, and the condition of market operation needs to be improved. Based on the analysis of the status of low-carbon buildings, investigating to running of low-carbon buildings from the low carbon building life cycle.%目前,我国低碳建筑市场在运行过程中缺乏政策、经济、技术等方面的有效支撑,还需进一步改善.本文在分析我国低碳建筑现状的基础上,从全寿命周期角度出发,对各阶段低碳建筑的运行进行探讨.

  15. STRATEGY FOR MAINTAINING AND RECOVERY OF WORKING ABILITY OF BUILDING AND ROAD-BUILDING MACHINERY WITH DUE ACCOUNT OF CHANGES IN OUTPUT PARAMETERS AT STAGE OF THEIR LIFE CYCLE OPERATION

    Directory of Open Access Journals (Sweden)

    A. Мaksimenko

    2013-01-01

    Full Text Available The paper proposes a strategy for maintaining and recovery of machinery working ability with due account of changes in technical and economic indicators (TEI in the process of its operation. Productivity, working cost of machine hour, operating efficiency ratio, inter-shift operating efficiency,  and other TEI are changing in the process of machine operation. While operating building and road-building machinery it is possible to obtain maximum effect only with the help of complex interacting events at stages of life cycle of a concrete machine and with due account of TEI dynamics in the process of its usage. 

  16. Cost of enlarged operating zone for an existing Francis runner

    Science.gov (United States)

    Monette, Christine; Marmont, Hugues; Chamberland-Lauzon, Joël; Skagerstrand, Anders; Coutu, André; Carlevi, Jens

    2016-11-01

    Traditionally, hydro power plants have been operated close to best efficiency point, the more stable operating condition for which they have been designed. However, because of changes in the electricity market, many hydro power plants operators wish to operate their machines differently to fulfil those new market needs. New operating conditions can include whole range operation, many start/stops, extensive low load operation, synchronous condenser mode and power/frequency regulation. Many of these new operating conditions may impose more severe fatigue damage than the traditional base load operation close to best efficiency point. Under these conditions, the fatigue life of the runner may be significantly reduced and reparation or replacement cost might occur sooner than expected. In order to design reliable Francis runners for those new challenging operating scenarios, Andritz Hydro has developed various proprietary tools and design rules. These are used within Andritz Hydro to design mechanically robust Francis runners for the operating scenarios fulfilling customer's specifications. To estimate residual life under different operating scenarios of an existing runner designed years ago for best efficiency base load operation, Andritz Hydro's design rules and tools would necessarily lead to conservative results. While the geometry of a new runner can be modified to fulfil all conservative mechanical design rules, the predicted fatigue life of an existing runner under off-design operating conditions may appear rather short because of the conservative safety factor included in the calculations. The most precise and reliable way to calculate residual life of an existing runner under different operating scenarios is to perform a strain gauge measurement campaign on the runner. This paper presents the runner strain gage measurement campaign of a mid-head Francis turbine over all the operating conditions available during the test, the analysis of the measurement signals

  17. Thermal vacuum real-life test of an Marconi Space and Defence Systems (MSDS) solar-array drive mechanism (MSDS 002). First four years of operation

    Science.gov (United States)

    Parker, K.; Douglas, A.; Burke, W. R.

    1981-01-01

    The first part of a 7 yr life test on a mechanism which turns a satellite solar array at 1rev/day is reported. A thermal transfer shroud, surrounding the mechanism in a vacuum chamber, is held at a constant temperature of 22.5 C while the shaft temperature, measured near the top of the shaft at the large bearing, is changed at 6-monthly intervals so that it operates alternately at 60 and 10 C. At the beginning of each 6-monthly cycle, 30 eclipse simulations are performed, i.e., the shaft temperature is reduced from 60 C to 0 C in 72 min and is returned to 60 C in as short a time as possible. Apart from a very small increase in motor power during eclipse simulation, no changes in the mechanism parameters occur with temperature. The mechanism operates within motor power and angular rotation accuracy specifications. The electrical noise on all slip rings increased during the first two years, but then slowly decreased. Certain slip ring pairs show a noise level in excess of the arbitrary limits set at the start of the test, and two slip ring pairs give large periodic noise transients which may be due to mechanical damage to the slip rings or brushes.

  18. Type Safe Extensible Programming

    Science.gov (United States)

    Chae, Wonseok

    2009-10-01

    Software products evolve over time. Sometimes they evolve by adding new features, and sometimes by either fixing bugs or replacing outdated implementations with new ones. When software engineers fail to anticipate such evolution during development, they will eventually be forced to re-architect or re-build from scratch. Therefore, it has been common practice to prepare for changes so that software products are extensible over their lifetimes. However, making software extensible is challenging because it is difficult to anticipate successive changes and to provide adequate abstraction mechanisms over potential changes. Such extensibility mechanisms, furthermore, should not compromise any existing functionality during extension. Software engineers would benefit from a tool that provides a way to add extensions in a reliable way. It is natural to expect programming languages to serve this role. Extensible programming is one effort to address these issues. In this thesis, we present type safe extensible programming using the MLPolyR language. MLPolyR is an ML-like functional language whose type system provides type-safe extensibility mechanisms at several levels. After presenting the language, we will show how these extensibility mechanisms can be put to good use in the context of product line engineering. Product line engineering is an emerging software engineering paradigm that aims to manage variations, which originate from successive changes in software.

  19. Torque-wrench extension

    Science.gov (United States)

    Peterson, D. H.

    1981-01-01

    Torque-wrench extension makes it easy to install and remove fasteners that are beyond reach of typical wrenches or are located in narrow spaces that prevent full travel of wrench handle. At same time, tool reads applied torque accurately. Wrench drive system, for torques up to 125 inch-pounds, uses 2 standard drive-socket extensions in aluminum frame. Extensions are connected to bevel gear that turns another bevel gear. Gears produce 1:1 turn ratio through 90 degree translation of axis of rotation. Output bevel has short extension that is used to attach 1/4-inch drive socket.

  20. Experimental Research on Operation Life of Special Magnetic Grease Seal%特种磁脂密封的寿命试验研究*

    Institute of Scientific and Technical Information of China (English)

    吴露; 张秋翔; 蔡纪宁; 李双喜; 李岚

    2013-01-01

    Aimed at the seal reliability problems of special magnetic grease in large motor evaporative cooling technolo-gy under the working condition of large diameter and clearance,an experimental device for special magnetic grease seal was designed. The effects of magnetic grease filling dosage,shaft speed,seal gap,cooling water flow and seal series on the seal life were researched through operation tests. The results show that the seal life of special magnetic grease can be im-proved by reducing filling dosage of magnetic grease and increasing seal gap under the same seal bearing capacity. The seal life of special magnetic grease has no obvious change with stable performance within certain range of the speed. When out of the speed,the seal life is gradually reduced with increasing of the speed. The seal life of special magnetic grease can be improved effectively by increasing the flow rate of cooling water and increasing seal series. But the seal life can not be obvi-ously increased with too much of the water flow,and the seal series is limited by the seal axial size. Therefore,comprehen-sive consideration should be given in the selection of these two parameters.%  针对大直径、大间隙工况下大型电机蒸发冷却技术中特种磁脂密封的可靠性问题,设计一种特种磁脂密封试验装置,通过试验研究磁脂填加量、转轴转速、密封间隙、冷却水流量以及密封级数对磁脂密封寿命的影响。结果表明:相同密封承压能力下,降低磁脂填加量、增大密封间隙对提高密封寿命起到显著作用。磁脂密封在一定转速范围内性能稳定,运转寿命无明显变化;当转速超过稳定范围时,随转速的增大,磁脂密封寿命将逐渐降低。增大冷却水流量、增加密封级数能有效提高磁脂密封寿命,但冷却水流量过大对密封寿命提高不明显,而密封级数则会受到密封轴向尺寸限制,为此在二者参数的选取上应给予综合考虑。

  1. Kentucky's Urban Extension Focus

    Science.gov (United States)

    Young, Jeffery; Vavrina, Charles

    2014-01-01

    Defining the success of Urban Extension units is sometimes challenging. For those Extension agents, specialists, administrators, and others who have worked to bring solid, research-based programming to urban communities, it is no surprise that working in these communities brings its own unique and sometimes difficult challenges. Kentucky's Urban…

  2. Extension Online: Utilizing Technology to Enhance Educational Outreach

    Science.gov (United States)

    Green, Stephen

    2012-01-01

    Extension Online is an Internet-based online course platform that enables the Texas AgriLife Extension Service's Family Development and Resource Management (FDRM) unit to reach tens of thousands of users across the U.S. annually with research-based information. This article introduces readers to Extension Online by describing the history of its…

  3. [Localization Establishment of an Interdisciplinary Intervention Model to Prevent Post-Operative Delirium in Older Patients Based on 'Hospital Elder Life Program'].

    Science.gov (United States)

    Wang, Yan-Yan; Liao, Yu-Lin; Gao, Lang-Li; Hu, Xiu-Ying; Yue, Ji-Rong

    2017-06-01

    Postoperative delirium is a significant complication in elderly patients. The occurrence of delirium may increase the related physical and psychological risks, delay the length of hospital stays, and even lead to death. According to the current evidence-based model, the application of interdisciplinary intervention may effectively prevent delirium, shorten the length of hospital stays, and save costs. To establish a culturally appropriate interdisciplinary intervention model for preventing postoperative delirium in older Chinese patients. The authors adapted the original version of the Hospital Elder Life Program (HELP©) from the Hebrew Senior Life Institute for Aging Research of Harvard University by localizing the content using additional medical resources and translating the modified instrument into Chinese. Furthermore, the final version of this interdisciplinary intervention model for postoperative delirium was developed in accordance with the "guideline of delirium: diagnosis, prevention and management produced by the National Institute for Health and Clinical Excellence in 2010" and the "clinical practice guideline for postoperative delirium in older adults" produced by American geriatrics society in 2014. Finally, the translated instrument was revised and improved using discussions, consultations, and pilot study. The abovementioned procedure generated an interdisciplinary intervention model for preventing postoperative delirium that is applicable to the Chinese medical environment. The content addresses personnel structure and assignment of responsibility; details of interdisciplinary intervention protocols and implementation procedures; and required personnel training. The revised model is expected to decrease the occurrence of post-operative delirium and other complications in elderly patients, to help them maintain and improve their function, to shorten the length of their hospital stays, and to facilitate recovery.

  4. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals Trauma Systems Consultation ... Your Operation Guidance for after the operation including review of attached equipment and ways for you to ...

  5. NURBS curve blending using extension

    Institute of Scientific and Technical Information of China (English)

    Yong-jin LIU; Rong-qi QIU; Xiao-hui LIANG

    2009-01-01

    Curve and surface blending is an important operation in CAD systems, in which a non-uniform rational B-spline (NURBS) has been used as the de facto standard. In local comer blending, two curves intersecting at that comer are first made disjoint, and then the third blending curve is added-in to smoothly join the two curves with G1-or G2-continuity. In this paper we present a study to solve the joint problem based on curve extension. The following nice properties of this extension algorithm are exploited in depth: (1) The parameterization of the original shapes does not change; (2) No additional fragments are created.Various examples are presented to demonstrate that our solution is simple and efficient.

  6. Rehabilitation treatment of ankylosis after relaxing and plastic operation of adhesion of knee extension apparatus%伸膝装置粘连松解成形术后康复治疗膝关节僵直

    Institute of Scientific and Technical Information of China (English)

    史桂秋; 尹中华

    2002-01-01

    Background:Ankylosis is the result of adhesion of knee extension apparatus that is often the complications of trauma of femoral shaft and knee .Because ankylosis will impair the flexion of knee joint,postoperational exercise is the key to rebuild flexing function of knee joint.

  7. Algebraic extensions of fields

    CERN Document Server

    McCarthy, Paul J

    1991-01-01

    ""...clear, unsophisticated and direct..."" - MathThis textbook is intended to prepare graduate students for the further study of fields, especially algebraic number theory and class field theory. It presumes some familiarity with topology and a solid background in abstract algebra. Chapter 1 contains the basic results concerning algebraic extensions. In addition to separable and inseparable extensions and normal extensions, there are sections on finite fields, algebraically closed fields, primitive elements, and norms and traces. Chapter 2 is devoted to Galois theory. Besides the fundamenta

  8. Analysis of capacitive effect and life estimation of hydrodynamic journal bearings on repeated starts and stops of a machine operating under the influence of shaft voltages

    Science.gov (United States)

    Prashad, Har; Rao, K. N.

    1994-07-01

    A theoretical analysis has been carried out to study the capacitive effect and life estimation of hydrodynamic journal bearings on repeated starts and stops of a machine operating under the influence of shaft voltages. The analysis gives the time required for the charge accumulation and increase of charge with time on the liner surface of a journal bearing based on bearing capacitance, resistance of film thickness, and the shaft voltage. Also, it investigates the effect of gradual leakage of the accumulated charges with time as the shaft voltage falls when the power supply to the machine is switched off. This paper gives an approach to determine the ratio of the number of shaft revolutions required for charge accumulation and gradual discharge of the accumulated charges on the liner surface of a bearing depending on bearing-to-shaft voltage. Also, the number of repeated starts and stops before initiation of craters on the liner surface of a hydrodynamic journal bearing is established to restrict deterioration and damage of the liner. The diagnosis has the potential to study the transient effect of the shaft voltages on a journal bearing during the start and stop cycle of a machine.

  9. Cotorsion Pair Extensions

    Institute of Scientific and Technical Information of China (English)

    De Xu ZHOU

    2009-01-01

    Assume that S is an almost excellent extension of R. Using functors Hom R(S,-) and -(×)R S, we establish some connections between classes of modules (L)R and (L)S, cotorsion pairs ((A)R, (A)R)and ((A)S, (B)S). If (L)S is a T-extension or (and) H-extension of (L)R, we show that (L)S is a (resp., monomorphic, epimorphic, special) preenveloping class if and only if so is (L)R. If (S, S) is a TH-extension of ((A)R,(B)R), we obtain that ((A)S,(B)S) is complete (resp., of finite type, of cofinite type, hereditary, perfect, n-tilting) if and only if so is ((A)R,(B)R).

  10. Type extension trees

    DEFF Research Database (Denmark)

    Jaeger, Manfred

    2006-01-01

    We introduce type extension trees as a formal representation language for complex combinatorial features of relational data. Based on a very simple syntax this language provides a unified framework for expressing features as diverse as embedded subgraphs on the one hand, and marginal counts...... of attribute values on the other. We show by various examples how many existing relational data mining techniques can be expressed as the problem of constructing a type extension tree and a discriminant function....

  11. Type extension trees

    DEFF Research Database (Denmark)

    Jaeger, Manfred

    2006-01-01

    We introduce type extension trees as a formal representation language for complex combinatorial features of relational data. Based on a very simple syntax this language provides a unified framework for expressing features as diverse as embedded subgraphs on the one hand, and marginal counts...... of attribute values on the other. We show by various examples how many existing relational data mining techniques can be expressed as the problem of constructing a type extension tree and a discriminant function....

  12. Extension of the Schrodinger equation

    Science.gov (United States)

    Somsikov, Vyacheslav

    2017-03-01

    Extension of the Schrodinger equation is submitted by removing its limitations appearing due to the limitations of the formalism of Hamilton, based on which this equation was obtained. For this purpose the problems of quantum mechanics arising from the limitations of classical mechanics are discussed. These limitations, in particular, preclude the use of the Schrodinger equation to describe the time symmetry violation. The extension of the Schrodinger equation is realized based on the principle of duality symmetry. According to this principle the dynamics of the systems is determined by the symmetry of the system and by the symmetry of the space. The extension of the Schrodinger equation was obtained from the dual expression of energy, represented in operator form. For this purpose the independent micro - and macro-variables that determine respectively the dynamics of quantum particle system relative to its center of mass and the movement of the center of mass in space are used. The solution of the extended Schrodinger equation for the system near equilibrium is submitted. The main advantage of the extended Schrodinger equation is that it is applicable to describe the interaction and evolution of quantum systems in inhomogeneous field of external forces.

  13. Long-Term Outcome and Quality of Life of Patients With Endometrial Carcinoma Treated With or Without Pelvic Radiotherapy in the Post Operative Radiation Therapy in Endometrial Carcinoma 1 (PORTEC-1) Trial

    NARCIS (Netherlands)

    Nout, Remi A.; van de Poll-Franse, Lonneke V.; Lybeert, Marnix L. M.; Warlam-Rodenhuis, Carla C.; Jobsen, Jan J.; Mens, Jan Willem M.; Lutgens, Ludy C. H. W.; Pras, Betty; van Putten, Wim L. J.; Creutzberg, Carien L.

    2011-01-01

    Purpose To determine the long-term outcome and health-related quality of life (HRQL) of patients with endometrial carcinoma (EC) treated with or without pelvic radiotherapy in the Post Operative Radiation Therapy in Endometrial Carcinoma 1 (PORTEC-1) trial. Patients and Methods Between 1990 and 1997

  14. Symmetric Functional Model for Extensions of Hermitian

    CERN Document Server

    Ryzhov, V

    2006-01-01

    This paper offers the functional model of a class of non-selfadjoint extensions of a Hermitian operator with equal deficiency indices. The explicit form of dilation of a dissipative extension is offered and the symmetric form of Sz.Nagy-Foia\\c{s} model as developed by B.~Pavlov is constructed. A variant of functional model for a general non-selfadjoint non-dissipative extension is formulated. We illustrate the theory by two examples: singular perturbations of the Laplace operator in~$L_2(\\Real^3)$ by a finite number of point interactions, and the Schr\\"odinger operator on the half axis~$(0, \\infty)$ in the Weyl limit circle case at infinity.

  15. Borosonic inspection and remaining useful operational life estimation of steam turbine rotors; Inspeccion borosonica y estimacion de vida remanente de rotores de turbinas de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Carnero P, Jose A; Dorantes G, Oscar; Munoz Q, Rodolfo; Serrano R, Luis E. [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2004-07-01

    The turbo-generators used in the electric power generation frequently go through transitory operations (start ups, shut downs or power changes). Such actions cause that certain critical components of the turbines, such as rotors and casings, are put under cycles of repetitive stresses, which consume its useful life. The frequency whereupon these transitory thermal cycles happen result in the presence of high thermo-mechanical stresses that produce fatigue (damage) in the rotor material. With time, at the increase of the material fatigue, fissures form that can inclusively lead to severe, catastrophic faults. The borosonic inspection consists in introducing and positioning an automatic probe in the central drill of the rotor, this allows the non-destructive inspection with longitudinal ultrasonic beam, ultrasonic cross-sectional and ultrasonic superficial. This way, it is possible to detect and locate geometric discontinuities (superficial and volumetric), in at least 100 mm of depth from the drill surface in its entire periphery and throughout the rotor length. [Spanish] Los turbogeneradores empleados en la generacion de energia electrica con frecuencia realizan operaciones transitorias (arranques, paros o cambios de potencia). Acciones tales, provocan que ciertos componentes criticos de las turbinas, como los rotores y carcasas, sean sometidos a ciclos de esfuerzos repetitivos, lo que consume su vida util. La frecuencia con que ocurren estos ciclos termicos transitorios da como resultado la presencia de altos esfuerzos termomecanicos que producen una fatiga (dano) en el material del rotor. Con el tiempo, al incrementarse la fatiga del material, se forman fisuras que pueden conducir a fallas severas, catastroficas inclusive. La inspeccion borosonica consiste en introducir y posicionar una sonda automatica en el barreno central del rotor, ello permite la inspeccion no destructiva con haz ultrasonico longitudinal, haz ultrasonico transversal y haz ultrasonico

  16. Safety and efficacy of botox injection in alleviating post-operative pain and improving quality of life in lower extremity limb lengthening and deformity correction

    Directory of Open Access Journals (Sweden)

    Finley Allen

    2007-09-01

    Full Text Available Abstract Background Distraction osteogenesis is the standard treatment for the management of lower limb length discrepancy of more than 3 cm and bone loss secondary to congenital anomalies, trauma or infection. This technique consists of an osteotomy of the bone to be lengthened, application of an external fixator, followed by gradual and controlled distraction of the bone ends. Although limb lengthening using the Ilizarov distraction osteogenesis principle yields excellent results in most cases, the technique has numerous problems and is not well tolerated by many children. The objective of the current study is to determine if Botulinum Toxin A (BTX-A, which is known to possess both analgesic and paralytic actions, can be used to alleviate post-operative pain and improve the functional outcome of children undergoing distraction osteogenesis. Methods/Design The study design consists of a multi centre, randomized, double-blinded, placebo-controlled trial. Patients between ages 5–21 years requiring limb lengthening or deformity correction using distraction will be recruited from 6 different sites (Shriners Hospital for Children in Montreal, Honolulu, Philadelphia and Portland as well as DuPont Hospital for Children in Wilmington, Delaware and Hospital for Sick Children in Toronto, Ont. Approximately 150 subjects will be recruited over 2 years and will be randomized to either receive 10 units per Kg of BTX-A or normal saline (control group intraoperatively following the surgery. Functional outcome effects will be assessed using pain scores, medication dosages, range of motion, flexibility, strength, mobility function and quality of life of the patient. IRB approval was obtained from all sites and adverse reactions will be monitored vigorously and reported to IRB, FDA and Health Canada. Discussion BTX-A injection has been widely used world wide with no major side effects reported. However, to the best of our knowledge, this is the first time BTX

  17. Neurocognitive function and quality of life in patients with newly diagnosed brain metastasis after treatment with intra-operative cesium-131 brachytherapy: a prospective trial.

    Science.gov (United States)

    Pham, Anthony; Yondorf, Menachem Z; Parashar, Bhupesh; Scheff, Ronald J; Pannullo, Susan C; Ramakrishna, Rohan; Stieg, Philip E; Schwartz, Theodore H; Wernicke, A Gabriella

    2016-03-01

    Intraoperative permanent Cesium-131 (Cs-131) brachytherapy can provide a viable alternative to WBRT with excellent response rates and minimal toxicity. This study reports the results of the prospective trial of the impact of intraoperative Cs-131 on neurocognitive function and quality of life (QoL) in patients with resected brain metastases. Between 2010 and 2012, 24 patients with newly diagnosed metastasis to the brain were accrued on a prospective protocol and treated with Cs-131 brachytherapy seeds after surgical resection. Physicians administered the mini-mental status examination (MMSE) and functional assessment of cancer therapy-brain (FACT-Br) questionnaire to all patients before treatment and again every 2 months for the duration of 6 months with additional follow-up again at 12 months. Wilcoxon rank sum test was used to analyze statistically significant changes in MMSE over time and paired t test was used to analyze changes in FACT-BR. There was a statistical improvement in overall FACT-BR score at 4 and 6 months of follow-up when compared to baseline (162 vs. 143, P = 0.004; 164 vs. 143, P = 0.005 respectively) with a non-significant trend toward improvement at 2 and 12 months (154 vs. 143, P = 0.067; 159 vs. 149, P = 0.4). MMSE score was statistically improved at 4 and up to 12 months compared to pre-treatment MMSE (30 vs. 29, P = 0.017; 30 vs. 29, P = 0.001 respectively). Patients with brain metastasis who received intra-operative permanent Cs-131 brachytherapy implants saw an improvement of their neurocognitive status and self-assessment of QoL. In addition to the excellent local control of metastasis, this approach may contribute to the improvements in cognitive function and QOL.

  18. EXTENSIVE READING IN CHINA

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    IntroductionMost teachers and students in China are quite familiar with the term‘extensive reading’,but how itshould be taught still remains a problem.This paper covers the aims of extensive reading and the methodsand materials used in the course.Then some practical suggestions will be given to make the course moreinteresting and efficient.According to Dzao(1990).extensive reading is‘the course where other reading skills-speed,predictionand making inference-can be developed,’and‘where there is practice in geting the gist,in summarisingmain ideas,in understanding the author’s purpose and theme...’.So the aims of this course are todevelop general reading skills,the ability,to read quickly and to grasp the main ideas of the text.Toachieve these,students must enlarge their vocabulary,so this is also regarded as one of the aims.

  19. Failure Mode Identification and End of Life Scenarios of Offshore Wind Turbines: A Review

    Directory of Open Access Journals (Sweden)

    Maria Martinez Luengo

    2015-08-01

    Full Text Available In 2007, the EU established challenging goals for all Member States with the aim of obtaining 20% of their energy consumption from renewables, and offshore wind is expected to be among the renewable energy sources contributing highly towards achieving this target. Currently wind turbines are designed for a 25-year service life with the possibility of operational extension. Extending their efficient operation and increasing the overall electricity production will significantly increase the return on investment (ROI and decrease the levelized cost of electricity (LCOE, considering that Capital Expenditure (CAPEX will be distributed over a larger production output. The aim of this paper is to perform a detailed failure mode identification throughout the service life of offshore wind turbines and review the three most relevant end of life (EOL scenarios: life extension, repowering and decommissioning. Life extension is considered the most desirable EOL scenario due to its profitability. It is believed that combining good inspection, operations and maintenance (O&M strategies with the most up to date structural health monitoring and condition monitoring systems for detecting previously identified failure modes, will make life extension feasible. Nevertheless, for the cases where it is not feasible, other options such as repowering or decommissioning must be explored.

  20. Android Access Control Extension

    Directory of Open Access Journals (Sweden)

    Anton Baláž

    2015-12-01

    Full Text Available The main objective of this work is to analyze and extend security model of mobile devices running on Android OS. Provided security extension is a Linux kernel security module that allows the system administrator to restrict program's capabilities with per-program profiles. Profiles can allow capabilities like network access, raw socket access, and the permission to read, write, or execute files on matching paths. Module supplements the traditional Android capability access control model by providing mandatory access control (MAC based on path. This extension increases security of access to system objects in a device and allows creating security sandboxes per application.

  1. Recent extensions to GALPROP

    CERN Document Server

    Strong, A W

    2015-01-01

    Some recent extensions to the GALPROP cosmic-ray propagation package are described. The enhancements include: an accurate solution option, improved convection formulation, alternative spatial boundary conditions, polarized synchrotron emission, new magnetic field models, updated gamma-ray production cross-sections, free-free radio emission and absorption, primary positrons, additional injection spectral breaks, deuterium production by pp fusion, hadronic energy losses, improved HEALPix skymap format, compatibility with latest HEALPix release, and various bug fixes. The Explanatory Supplement has been extensively updated, including details of these enhancements. A compatible plot package GALPLOT for GALPROP output is also provided, as well as other related software.

  2. 已婚育龄妇女宫颈癌术后性生活质量的调查分析%Investigation and analysis in the sexual life quality of females at the reproductive ages after cervix cancer operation

    Institute of Scientific and Technical Information of China (English)

    孙美玲; 孟春艳; 刘梅梅; 路丽

    2008-01-01

    Objective To explore the sexual life quality of females at the reproductive ages after cervix cancer operation and supply evidence for establishment of correspondindg nursing measure. Methods We investigated the frequency of sexual life and satisfaction degree of sexual life in 40 females at the reproductive ages after cervix cancer operation by face-to-face investigations using questionnaires before and 4 months after operations. Then the difference of sexual life quality before and after operation were compared and analyzed. Results The frequency of sexual life (P<0.01,P<0.05) and satisfaction degree of sexual life (P<0.01,P<0.05) were evidently decreased. The sexual life quality was lower than that before operation. Conclusion The sexual life quality could be affected by many factors such as economic conditions, culture background, sexual conceptions and the attitude of their partners.%目的 了解育龄妇女宫颈癌术后性生活的情况,为制订相应的护理措施提供依据.方法 通过调查问卷方式进行逐一面对面调查,对40例育龄期宫颈癌患者,进行手术前、手术后4个月的性生活频率、性生活满意度的调查,比较分析宫颈癌患者手术前后性生活质量的差别.结果 宫颈癌患者术后的性生活频率及性生活满意度明显降低(P<0.05),性生活质量明显低于手术前.结论 经济条件、文化背景、性观念及配偶的态度等因素对宫颈癌患者术后的性生活质量均有影响.

  3. Mobile Applications for Extension

    Science.gov (United States)

    Drill, Sabrina L.

    2012-01-01

    Mobile computing devices (smart phones, tablets, etc.) are rapidly becoming the dominant means of communication worldwide and are increasingly being used for scientific investigation. This technology can further our Extension mission by increasing our power for data collection, information dissemination, and informed decision-making. Mobile…

  4. Extensions of tempered representations

    NARCIS (Netherlands)

    Opdam, E.; Solleveld, M.

    2013-01-01

    Let π, π′ be irreducible tempered representations of an affine Hecke algebra H with positive parameters. We compute the higher extension groups Ext nH(π,π′) explicitly in terms of the representations of analytic R-groups corresponding to π and π′. The result has immediate applications to the computa

  5. Extending Extensive Reading

    Science.gov (United States)

    Day, Richard R.

    2015-01-01

    The April 2015 issue of "Reading in a Foreign Language" featured a discussion forum on extensive reading (ER). Most of the authors, recognized authorities on ER, discussed their views of the principles of ER, particularly in establishing and conducting ER programs. The purpose of this discussion is to review developments in the practice…

  6. 妇科恶性肿瘤患者41例术后性生活分析%Sexual life analysis in 41 patients after operation of gynecological malignant tumors

    Institute of Scientific and Technical Information of China (English)

    衣尚

    2002-01-01

    @@ Gynecological malignant tumors can affect female characteristics in women.Although the malignant tumors might attack different parts or cause different lesions they have similar effects on the patients. The patients feel that they don't have sexual attractive force any longer and have hyposexuality.The purpose of the present article is to study the sexual life in patients with gynecological malignant tumors after operation so that the clinicians could grasp physiological and psychological conditions of the patients and improve their quality of life.

  7. Modal extension rule

    Institute of Scientific and Technical Information of China (English)

    WU Xia; SUN Jigui; LIN Hai; FENG Shasha

    2005-01-01

    Modal logics are good candidates for a formal theory of agents. The efficiency of reasoning method in modal logics is very important, because it determines whether or not the reasoning method can be widely used in systems based on agent. In this paper,we modify the extension rule theorem proving method we presented before, and then apply it to P-logic that is translated from modal logic by functional transformation. At last, we give the proof of its soundness and completeness.

  8. Supersymmetric extension of the Snyder algebra

    Energy Technology Data Exchange (ETDEWEB)

    Gouba, L., E-mail: lgouba@ictp.it [Abdus Salam International Centre for Theoretical Physics (ICTP), Strada Costiera 11, 34014 Trieste (Italy); Stern, A., E-mail: astern@bama.ua.edu [Dept. of Physics and Astronomy, Univ. of Alabama, Tuscaloosa, Al 35487 (United States)

    2012-04-11

    We obtain a minimal supersymmetric extension of the Snyder algebra and study its representations. The construction differs from the general approach given in Hatsuda and Siegel ( (arXiv:hep-th/0311002)) and does not utilize super-de Sitter groups. The spectra of the position operators are discrete, implying a lattice description of space, and the lattice is compatible with supersymmetry transformations. -- Highlights: Black-Right-Pointing-Pointer A new supersymmetric extension of the Snyder algebra is constructed. Black-Right-Pointing-Pointer The extension is minimal and the construction does not involve supersymmetric de Sitter algebras. Black-Right-Pointing-Pointer An involution is defined for the system and discrete representations are constructed. Black-Right-Pointing-Pointer The representations imply a spatial lattice and the lattice spacing is half that of the bosonic case. Black-Right-Pointing-Pointer A differential operator representation is given for fields on super-momentum space.

  9. Life cycle of transformer oil

    Directory of Open Access Journals (Sweden)

    Đurđević Ksenija R.

    2008-01-01

    Full Text Available The consumption of electric power is constantly increasing due to industrialization and population growth. This results in much more severe operating conditions of transformers, the most important electrical devices that make integral parts of power transmission and distribution systems. The designed operating life of the majority of worldwide transformers has already expired, which puts the increase of transformer reliability and operating life extension in the spotlight. Transformer oil plays a very important role in transformer operation, since it provides insulation and cooling, helps extinguishing sparks and dissolves gases formed during oil degradation. In addition to this, it also dissolves moisture and gases from cellulose insulation and atmosphere it is exposed to. Further and by no means less important functions of transformer are of diagnostic purpose. It has been determined that examination and inspection of insulation oil provide 70% of information on transformer condition, which can be divided in three main groups: dielectric condition, aged transformer condition and oil degradation condition. By inspecting and examining the application oil it is possible to determine the condition of insulation, oil and solid insulation (paper, as well as irregularities in transformer operation. All of the above-mentioned reasons and facts create ground for the subject of this research covering two stages of transformer oil life cycle: (1 proactive maintenance and monitoring of transformer oils in the course of utilization with reference to influence of transformer oil condition on paper insulation condition, as well as the condition of the transformer itself; (2 regeneration of transformer oils for the purpose of extension of utilization period and paper insulation revitalization potential by means of oil purification. The study highlights advantages of oil-paper insulation revitalization over oil replacement. Besides economic, there are

  10. Journal of Agricultural Extension Vol. 15 (2), December, 2011 http ...

    African Journals Online (AJOL)

    Irohibe and Agwu

    well as factors for enhancing its performance were studied. ... implemented across the globe. ... ministry-based extension system, project based extension, sectoral/ ... develop analytical skill, critical thinking and creativity, and also help them to learn how ... animal cycle. .... test possible innovation under real life condition.

  11. Modification of the Fc Region of a Human Anti-oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half-life in Cynomolgus Monkeys.

    Science.gov (United States)

    Nnane, Ivo P; Han, Chao; Jiao, Qun; Tam, Susan H; Davis, Hugh M; Xu, Zhenhua

    2017-01-28

    The purpose of this study was to evaluate the pharmacokinetics (PK) of anti-oncostatin M (OSM) IgG1 monoclonal antibodies, CNTO 1119 and its Fc variant (CNTO 8212), which incorporates the LS(Xtend) mutation to extend terminal half-life (T1/2 ), after a single intravenous (IV) or subcutaneous (SC) administration in cynomolgus monkeys, and to predict human PK. In study 1, single doses of CNTO 1119 and CNTO 8212 were administered IV or SC at 3 mg/kg to cynomolgus monkeys (n = 3 per group). In study 2, single doses of CNTO 8212 were administered IV at 1, 5 or 20 mg/kg, or SC at 5 mg/kg to cynomolgus monkeys (n = 5 per group). Serial blood samples were collected for assessment of serum concentrations of CNTO 1119 and/or CNTO 8212. A two-compartment population PK model with first-order elimination was utilized to simultaneously describe the serum concentrations of CNTO 1119 and CNTO 8212 over time after IV and SC administration in cynomolgus monkeys. The typical population PK parameter estimates for CNTO 1119 in cynomolgus monkeys were clearance (CL) = 2.81 mL/day/kg, volume of distribution of central compartment (V1 ) = 31.3 mL/kg, volume of distribution of peripheral compartment (V2 ) = 23.3 mL/kg, absolute bioavailability (F) = 0.84 and T1/2 = 13.4 days. In comparison, the typical population PK parameter estimates for CNTO 8212 in cynomolgus monkeys were CL = 1.41 mL/day/kg, V1 = 39.8 mL/kg, V2 = 32.6 mL/kg, F = 0.75 and T1/2 = 35.7 days. The mean CL of CNTO 8212 was ~50% lower compared with that for CNTO 1119 in cynomolgus monkeys. The overall volume of distribution (V1 +V2 ) for CNTO 8212 was about 32% larger compared with that for CNTO 1119, but generally similar to the vascular volume in cynomolgus monkeys. The T1/2 of CNTO 8212 was significantly (p monkeys. Thus, the modification of the Fc portion of an anti-OSM IgG1 mAb for higher FcRn binding affinity resulted in lower systemic clearance and a longer terminal half-life in cynomolgus monkeys. CNTO 8212

  12. EXTENSIONS OF SOME INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    By using a simple analytic method the following inequalities are proved:(bx+y-ax+y)/(bx-ax)≥[(x+y)/x][(a+b)/2]y,for 0<a<b,x≥1,y>0,x+y≥2;(bx+y-ax+y)/(bx-ax)<[(x+y)/x][(a+b)/2]y,for0<a<b,0<x<1,y>0,x+y≤2.These inequalities are the extensions of inequalities of Qi Feng, Xu Senlin and Zheng Lin. And a conjection of Qi Feng is proved not true.

  13. Extensive air showers

    CERN Document Server

    Rao, M V S

    1997-01-01

    Ultrahigh energy cosmic rays carry information about their sources and the intervening medium apart from providing a beam of particles for studying certain features of high energy interactions currently inaccessible at man-made accelerators. They can at present be studied only via the extensive air showers (EAS's) they generate while passing through the Earth's atmosphere, since their fluxes are too low for the experiments of limited capability flown in balloons and satellites. The EAS is generated by a series of interactions of the primary cosmic ray and its progeny with the atmospheric nucle

  14. Shelf-life extension of refrigerated sea bass slices wrapped with fish protein isolate/fish skin gelatin-ZnO nanocomposite film incorporated with basil leaf essential oil.

    Science.gov (United States)

    Arfat, Yasir Ali; Benjakul, Soottawat; Vongkamjan, Kitiya; Sumpavapol, Punnanee; Yarnpakdee, Suthasinee

    2015-10-01

    Microbiological, chemical and sensory changes of sea bass slices wrapped with fish protein isolate (FPI)/fish skin gelatin (FSG) films incorporated with 3 % ZnO nanoparticles (ZnONP) (w/w, based on protein content) and 100 % basil leaf essential oil (BEO) (w/w, based on protein content) during storage of 12 days at 4 °C were investigated. Sea bass slices wrapped with FPI/FSG-ZnONP-BEO film had the lowest growth of psychrophilic bacteria, lactic acid bacteria and spoilage microorganisms including Pseudomonas , H2S-producing bacteria and Enterobacteriaceae throughout storage of 12 days in comparison with those wrapped with FPI/FSG-BEO, FPI/FSG-ZnONP, FPI/FSG film, polypropylene film (PP film) and the control (without wrapping), respectively (P life of sea bass slices was longest for samples wrapped with FPI/FSG-ZnONP-BEO film (12 days), as compared to the control (6 days) (P < 0.05).

  15. Optimization of life cycle management costs

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, A.K. [Stone & Webster Engineering Corp., Boston, MA (United States)

    1994-12-31

    As can be seen from the case studies, a LCM program needs to address and integrate, in the decision process, technical, political, licensing, remaining plant life, component replacement cycles, and financial issues. As part of the LCM evaluations, existing plant programs, ongoing replacement projects, short and long-term operation and maintenance issues, and life extension strategies must be considered. The development of the LCM evaluations and the cost benefit analysis identifies critical technical and life cycle cost parameters. These {open_quotes}discoveries{close_quotes} result from the detailed and effective use of a consistent, quantifiable, and well documented methodology. The systematic development and implementation of a plant-wide LCM program provides for an integrated and structured process that leads to the most practical and effective recommendations. Through the implementation of these recommendations and cost effective decisions, the overall power production costs can be controlled and ultimately lowered.

  16. [Physical rehabilitation in extensively burned patients].

    Science.gov (United States)

    Martín Martínez, V; Díez Sanz, Ma J; Corona Fernández, O; García Aragón, A; González Fraile, L

    2014-02-01

    The rehabilitation of the extensively burned patient aims to prevent and minimize consequences of the own lesion this is supported by three pillars: 1) postural treatment to prevent contractures; 2) kinesiotherapy to maintain/restore joint range of movement and muscle strength; 3) functional recovery. Physical therapy is essential in the multidisciplinary team. A coordinated team assures better results and positively influences the quality of life of the patients.

  17. Life Extending Minimum-Time Path Planning for Hexapod Robot

    Directory of Open Access Journals (Sweden)

    Xin Wu

    2011-06-01

    Full Text Available This paper presents a minimum‐time path planning scheme for life‐extending operation of legged robots, illustrated with a six‐legged walking robot (hexapod. The focus of this study is on extending the bearing fatigue life for leg joints. As a typical treatment, the minimum‐time path planning is performed through a bisecting‐plane (BP algorithm with the constraints of maximum joint angular velocity and acceleration. Based on bearing fatigue life theory, its fatigue life increases while the dynamic radial force on the bearing decreases. By imposing more rigorous constraint on the dynamic radial force, the minimum‐time path planning algorithm is thus revised by reinforcing the constraint of maximum radial force based on the expectation of life extension. A symmetric hexapod with 18 degree‐of‐freedom (DOF is adopted as the illustrative example for simulation study. The simulation results validate the effectiveness of possible life extending with moderate compromise in transient performance.

  18. Leveling of battery load and extension of battery life by serial connection of electric double layer capacitors with batteries for electric vehicles. Experimental results on the small model; Denki jidoshayo denchi to denki nijuso capacitor no chokuretsu setsuzoku ni yoru denchi futan no heijunka oyobi denchijumyo no enshinka. (kogata model ni yoru jikken seika). Kogata model ni yoru jikken seika

    Energy Technology Data Exchange (ETDEWEB)

    Takehara, J.; Okubo, N.; Miyaoka, K. [Chugoku Electric Power Co. Inc., Hiroshima (Japan)

    1996-10-25

    The load leveling method of batteries for electric vehicles was studied for extension of a battery life and mileage every charging. Under large load fluctuation conditions such as deceleration and acceleration, use of electric power sources other than battery for peek load at acceleration can improve a battery life, output power capacity and mileage every charging. Combination of effective recovery of regenerative power at deceleration with its discharge at acceleration is one of the effective methods. The electric double layer capacitors are serially connected with the batteries, regenerative power is charged only into the capacitors, and both voltages of the battery and capacitor are applied to a power circuit. Battery load is reduced by load on the capacitor. Until the capacitor is re-charged by regenerative power after full discharge, power is supplied only by battery through a diode. Capacitor power is used as effectively as possible until approaching considerably low voltage. As peak load of the battery is reduced by 30%, the mileage increases by 5.7%, and the battery cycle life becomes 1.5 times longer. 7 refs., 5 figs., 3 tabs.

  19. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and Emergency Preparedness Rural Trauma Team Development Course Trauma Evaluation and Management Trauma CME Nora ...

  20. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Online Guide to Choosing a Surgical Residency Practice Management Workshops Patients and Family Patient Education Patient Education ... Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and ...

  1. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Online Guide to Choosing a Surgical Residency Practice Management Workshops Patients and Family Patient Education Patient Education ... Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and ...

  2. Re-appraisal and extension of the Gratton-Vargas two-dimensional analytical snowplow model of plasma focus. III. Scaling theory for high pressure operation and its implications

    Science.gov (United States)

    Auluck, S. K. H.

    2016-12-01

    practice of designs optimized at pressures less than 10 mbar of deuterium. These examples show that the upper limit for operating pressure is of technological (and not physical) origin.

  3. Health-related quality of life is poor but does not vary with cardiovascular disease burden among patients operated for severe atherosclerotic disease

    NARCIS (Netherlands)

    Haitjema, Saskia; de Borst, Gert Jan; de Vries, Jean Paul; Moll, Frans; Pasterkamp, Gerard; den Ruijter, Hester

    2014-01-01

    Background: Patients with cardiovascular disease (CVD) are reported to have a poorer health-related quality of life (HRQoL) compared to healthy age- and gender-matched individuals. Moreover, HRQoL seems to predict survival in CVD populations. We studied HRQoL and the association with outcome during

  4. Quotient Semigroups and Extension Semigroups

    Indian Academy of Sciences (India)

    Rong Xing; Changguo Wei; Shudong Liu

    2012-08-01

    We discuss properties of quotient semigroup of abelian semigroup from the viewpoint of *-algebra and apply them to a survey of extension semigroups. Certain interrelations among some equivalence relations of extensions are also considered.

  5. Nuclear plant operation: achieving excellence through quality

    Energy Technology Data Exchange (ETDEWEB)

    Bergstrom, L. [Barseback Nuclear Power Plant (Sweden); Bergeron, J.P. [Electricite de France (EDF), 75 - Paris (France); Coakley, W. [and others

    1992-07-01

    Nuclear power operation is characterised by a very high level of safety and availability resulting in economically competitive electricity production. This achievement must not only be maintained but must be further developed if nuclear power is to regain momentum in the light of its widely recognized environmental advantages. Therefore this meeting bring together all those, managers and technical staff, responsible for the operation of the nuclear in order to allow them to exchange views, experience and knowledge on fundamental aspects such as: management philosophy, quality assurance, human resources and international co-operation; focusing on training (incident analysis and management), human factors and experience feedback; maintenance philosophy, life extension and upgrading, organisation and administration. (A.L.B.)

  6. Operations and maintenance philosophy

    Energy Technology Data Exchange (ETDEWEB)

    DUNCAN, G.P.

    1999-10-28

    This Operations and Maintenance (O&M) Philosophy document is intended to establish a future O&M vision, with an increased focus on minimizing worker exposure, ensuring uninterrupted retrieval operations, and minimizing operation life-cycle cost. It is intended that this document would incorporate O&M lessons learned into on-going and future project upgrades.

  7. Why Army Program Managers Struggle As Life Cycle Managers: A Study of the PM’s Roles, Responsibilities, and Barriers In the Execution of Operations and Support

    Science.gov (United States)

    2016-09-01

    Support, O&S, life cycle 15. NUMBER OF PAGES 77 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY CLASSIFICATION...Instruction DRU Direct Report Unit E&MD Engineering and Manufacturing Development FD Full Deployment FORSCOM U.S. Army Forces Command FRP Full...another all the way up to the Secretary of Defense. This separation helps to focus PMs on supporting the programs they manage in a balanced fashion

  8. Covariant Projective Extensions

    Institute of Scientific and Technical Information of China (English)

    许天周; 梁洁

    2003-01-01

    @@ The theory of crossed products of C*-algebras by groups of automorphisms is a well-developed area of the theory of operator algebras. Given the importance and the success ofthat theory, it is natural to attempt to extend it to a more general situation by, for example,developing a theory of crossed products of C*-algebras by semigroups of automorphisms, or evenof endomorphisms. Indeed, in recent years a number of papers have appeared that are concernedwith such non-classicaltheories of covariance algebras, see, for instance [1-3].

  9. Benchmark Tests for Stirling Convertor Heater Head Life Assessment Conducted

    Science.gov (United States)

    Krause, David L.; Halford, Gary R.; Bowman, Randy R.

    2004-01-01

    A new in-house test capability has been developed at the NASA Glenn Research Center, where a critical component of the Stirling Radioisotope Generator (SRG) is undergoing extensive testing to aid the development of analytical life prediction methodology and to experimentally aid in verification of the flight-design component's life. The new facility includes two test rigs that are performing creep testing of the SRG heater head pressure vessel test articles at design temperature and with wall stresses ranging from operating level to seven times that (see the following photograph).

  10. A Classification of BPEL Extensions

    Directory of Open Access Journals (Sweden)

    Oliver Kopp

    2011-10-01

    Full Text Available The Business Process Execution Language (BPEL has emerged as de-facto standard for business processes implementation. This language is designed to be extensible for including additional valuable features in a standardized manner. There are a number of BPEL extensions available. They are, however, neither classified nor evaluated with respect to their compliance to the BPEL standard. This article fills this gap by providing a framework for classifying BPEL extensions, a classification of existing extensions, and a guideline for designing BPEL extensions.

  11. Effectiveness of Agricultural Extension Activities

    Directory of Open Access Journals (Sweden)

    Ali AL-Sharafat

    2012-01-01

    Full Text Available Problem statement: Jordans agricultural extension service is seriously under-staffed and its effectiveness is consequently compromised. Reservations are being expressed about the performance and capability of the agricultural extension system in Jordan. The performance of this sector has been disappointing and has failed to transfer agricultural technology to the farmers. The main objective of this study is to assess the effectiveness of Jordans agricultural extension services. Approach: The effect of extension services on olive productivity in the study area was investigated. A total number of 60 olive producers were selected to be interviewed for this study. This number was enough to achieve the study objectives. The interviewed producers were distributed almost equally within olive production locations in the study area. The sample obtained through the simple random sampling technique. The two groups had been chosen and distributed randomly into an experimental group (30 farmers; 10 for each source of extension service and control group (30 farmers. The experimental group received extension services and the control group received no extension services. Two interview-cum-structured questionnaires were designed and used to collect information and data for this study. The first instrument was designed for farmers who received extension services and the second from farmers who received no extension services. Another questionnaire was designed for administrators of extension organizations concerned with providing extension services to farmers. To find the differences that may exist between two studied groups, One Way Analysis of Variance (ANOVA, t-test and LSD test via Statistical Package for Social Sciences software (SPSS were used. The average net profit obtained from an area of one dynamo of olive farm was the main item to be considered in determining the effectiveness of agricultural extension activities. Results and Conclusion: The results of

  12. Capacitated arc routing problem and its extensions in waste collection

    Science.gov (United States)

    Fadzli, Mohammad; Najwa, Nurul; Luis, Martino

    2015-05-01

    Capacitated arc routing problem (CARP) is the youngest generation of graph theory that focuses on solving the edge/arc routing for optimality. Since many years, operational research devoted to CARP counterpart, known as vehicle routing problem (VRP), which does not fit to several real cases such like waste collection problem and road maintenance. In this paper, we highlighted several extensions of capacitated arc routing problem (CARP) that represents the real-life problem of vehicle operation in waste collection. By purpose, CARP is designed to find a set of routes for vehicles that satisfies all pre-setting constraints in such that all vehicles must start and end at a depot, service a set of demands on edges (or arcs) exactly once without exceeding the capacity, thus the total fleet cost is minimized. We also addressed the differentiation between CARP and VRP in waste collection. Several issues have been discussed including stochastic demands and time window problems in order to show the complexity and importance of CARP in the related industry. A mathematical model of CARP and its new version is presented by considering several factors such like delivery cost, lateness penalty and delivery time.

  13. Capacitated arc routing problem and its extensions in waste collection

    Energy Technology Data Exchange (ETDEWEB)

    Fadzli, Mohammad; Najwa, Nurul [Institut Matematik Kejuruteraan, Universiti Malaysia Perlis, Kampus Pauh Putra, 02600 Arau, Perlis (Malaysia); Luis, Martino [Othman Yeop Abdullah Graduate School of Business, Universiti Utara Malaysia, 06010 Sintok, Kedah (Malaysia)

    2015-05-15

    Capacitated arc routing problem (CARP) is the youngest generation of graph theory that focuses on solving the edge/arc routing for optimality. Since many years, operational research devoted to CARP counterpart, known as vehicle routing problem (VRP), which does not fit to several real cases such like waste collection problem and road maintenance. In this paper, we highlighted several extensions of capacitated arc routing problem (CARP) that represents the real-life problem of vehicle operation in waste collection. By purpose, CARP is designed to find a set of routes for vehicles that satisfies all pre-setting constraints in such that all vehicles must start and end at a depot, service a set of demands on edges (or arcs) exactly once without exceeding the capacity, thus the total fleet cost is minimized. We also addressed the differentiation between CARP and VRP in waste collection. Several issues have been discussed including stochastic demands and time window problems in order to show the complexity and importance of CARP in the related industry. A mathematical model of CARP and its new version is presented by considering several factors such like delivery cost, lateness penalty and delivery time.

  14. Development of life evaluation technology for nuclear power plant components

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin [Sungkyunkwan Univ., Seoul (Korea, Republic of); Kwon, J. D. [Yeungnam Univ., Gyeongsan (Korea, Republic of); Kang, K. J. [Chonnam National Univ., Gwangju (Korea, Republic of)] (and others)

    2001-03-15

    This research focuses on development of reliable life evaluation technology for nuclear power plant (NPP) components, and is divided into two parts, development of life evaluation systems for pressurized components and evaluation of applicability of emerging technology to operating plants. For the development of life evaluation system for nuclear pressure vessels, the following seven topics are covered: development of expert systems for integrity assessment of pressurized components, development of integrity evaluation systems of steam generator tubes, prediction of failure probability for NPP components based on probabilistic fracture mechanics, development of fatigue damage evaluation technique for plant life extension, domestic round robin analysis for pressurized thermal shock of reactor vessels, domestic round robin analysis of constructing P--T limit curves for reactor vessels, and development of data base for integrity assessment. For evaluation of applicability of emerging technology to operating plants, on the other hand, the following eight topics are covered: applicability of the Leak-Before-Break analysis to Cast S/S piping, collection of aged material tensile and toughness data for aged Cast S/S piping, finite element analyses for load carrying capacity of corroded pipes, development of Risk-based ISI methodology for nuclear piping, collection of toughness data for integrity assessment of bi-metallic joints, applicability of the Master curve concept to reactor vessel integrity assessment, measurement of dynamic fracture toughness, and provision of information related to regulation and plant life extension issues.

  15. Developing Extension Professionals to Develop Extension Programs: A Case Study for the Changing Face of Extension

    Directory of Open Access Journals (Sweden)

    Scott R. Cummings

    2015-06-01

    Full Text Available Development of Cooperative Extension programs depends upon the skills and abilities of competent Extension professionals. The most effective manner of building program development competencies in these Extension professionals is through professional development. A wide variety of competencies are necessary for Extension professionals to develop programs, including strong interpersonal skills. Differences exist between the professional development efforts of Extension institutions and are highlighted herein. Major challenges to delivery of professional development include time and budget, but these can be overcome through planning and innovation and use of online or hybrid methods. Professional development for program development is essential to furthering Extension’s mission, especially during times of rapid change.

  16. Possibilities for the detection of microbial life on extrasolar planets.

    Science.gov (United States)

    Knacke, Roger F

    2003-01-01

    We consider possibilities for the remote detection of microbial life on extrasolar planets. The Darwin/Terrestrial Planet Finder (TPF) telescope concepts for observations of terrestrial planets focus on indirect searches for life through the detection of atmospheric gases related to life processes. Direct detection of extraterrestrial life may also be possible through well-designed searches for microbial life forms. Satellites in Earth orbit routinely monitor colonies of terrestrial algae in oceans and lakes by analysis of reflected ocean light in the visible region of the spectrum. These remote sensing techniques suggest strategies for extrasolar searches for signatures of chlorophylls and related photosynthetic compounds associated with life. However, identification of such life-related compounds on extrasolar planets would require observations through strong, interfering absorptions and scattering radiances from the remote atmospheres and landmasses. Techniques for removal of interfering radiances have been extensively developed for remote sensing from Earth orbit. Comparable techniques would have to be developed for extrasolar planet observations also, but doing so would be challenging for a remote planet. Darwin/TPF coronagraph concepts operating in the visible seem to be best suited for searches for extrasolar microbial life forms with instruments that can be projected for the 2010-2020 decades, although resolution and signal-to-noise ratio constraints severely limit detection possibilities on terrestrial-type planets. The generation of telescopes with large apertures and extremely high spatial resolutions that will follow Darwin/TPF could offer striking possibilities for the direct detection of extrasolar microbial life.

  17. Framatome ANP worldwide experience in ageing and plant life management

    Energy Technology Data Exchange (ETDEWEB)

    Daeuwel, W.; Kastner, B.; Nopper, H. [Framatome ANP (Germany)

    2004-07-01

    The deregulation of the power generation industry has resulted in increased competitive pressure and is forcing operators to improve plant operating economy while maintaining high levels of plant safety. A key factor to meet this challenge is to apply a comprehensive plant life management (PLIM) approach which addresses all relevant ageing and degradation mechanisms regarding the safety concept, plant components and documentation, plant personnel, consumables, operations management system and administrative controls. For this reason, Framatome ANP has developed an integrated PLIM concept focussing on the safety concept, plant components and documentation. Representative examples for plant wide analyses are described in the following. The results of the analyses support the plant owner for taking the strategic decisions, involved in plant life extension (PLEX). (orig.)

  18. Electrical power transmission and distribution aging and life extension techniques

    CERN Document Server

    Chudnovsky, Bella H

    2012-01-01

    ""The focus of this unique reference book is four critical areas in the manufacturing of power distribution components. These areas are plating, lubrication, insulator failure, and maintenance. ... The many SEM images, x-ray studies, photos, and tabular data make for a very convenient reference source for diagnosing plating problems. ... Examples often help to drive home a point, and many case studies illustrating the various failure modes described throughout the book are included. These could prove to be an invaluable source of information when trying to diagnose unknown field failures. ...

  19. Application of subsize specimens in nuclear plant life extension

    Energy Technology Data Exchange (ETDEWEB)

    Rosinski, S.T. [Sandia National Labs., Albuquerque, NM (United States); Kumar, A.S. [Missouri Univ., Rolla, MO (United States); Cannon, S.C. [Westinghouse Hanford Co., Richland, WA (United States); Hamilton, M.L. [Pacific Northwest Lab., Richland, WA (United States)

    1991-12-31

    The US Department of Energy is sponsoring a research effort through Sandia National Laboratories and the University of Missour-Rolla to test a correlation for the upper shelf energy (USE) values obtained from the impact testing of subsize Charpy V-notch specimens to those obtained from the testing of full size samples. The program involves the impact testing of unirradiated and irradiated full, half, and third size Charpy V-notch specimens. To verify the applicability of the correlation on LWR materials unirradiated and irradiated full, half, and third size Charpy V-notch specimens of a commercial pressure vessel steel (ASTM A533 Grade B) will be tested. This paper will provide details of the program and present results obtained from the application of the developed correlation methodology to the impact testing of the unirradiated full, half, and third size A533 Grade B Charpy V-notch specimens.

  20. Application of subsize specimens in nuclear plant life extension

    Energy Technology Data Exchange (ETDEWEB)

    Rosinski, S.T. (Sandia National Labs., Albuquerque, NM (United States)); Kumar, A.S. (Missouri Univ., Rolla, MO (United States)); Cannon, S.C. (Westinghouse Hanford Co., Richland, WA (United States)); Hamilton, M.L. (Pacific Northwest Lab., Richland, WA (United States))

    1991-01-01

    The US Department of Energy is sponsoring a research effort through Sandia National Laboratories and the University of Missour-Rolla to test a correlation for the upper shelf energy (USE) values obtained from the impact testing of subsize Charpy V-notch specimens to those obtained from the testing of full size samples. The program involves the impact testing of unirradiated and irradiated full, half, and third size Charpy V-notch specimens. To verify the applicability of the correlation on LWR materials unirradiated and irradiated full, half, and third size Charpy V-notch specimens of a commercial pressure vessel steel (ASTM A533 Grade B) will be tested. This paper will provide details of the program and present results obtained from the application of the developed correlation methodology to the impact testing of the unirradiated full, half, and third size A533 Grade B Charpy V-notch specimens.

  1. SAVY 4000 Container Filter Design Life and Extension Implementation

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Murray E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Reeves, Kirk Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Smith, Paul Herrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stone, Timothy Amos [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-23

    The SAVY 4000 is a general purpose, reusable container for the storage of solid nuclear material inside a nuclear facility. The canister has a permitted loading for material with a thermal output not to exceed 25 watts. This wattage limit applies to all containers, regardless of their size.

  2. Chromium Elimination and Cannon Life Extension for Gun Tubes

    Science.gov (United States)

    2012-08-30

    Material Science Mr. Josh Hydrew ARES Inc. Manufacturing Mr. Don Butler High Energy Metals, Inc. Cladding Technology • To eliminate...process. • To demonstrate and validate the effectiveness of a cannon tube explosively clad with tantalum-10 tungsten (Ta-10W) liner to decrease...erosion- resistant chrome cobalt alloy matrix with 15% tungsten. Stellite is used as M60 machine gun barrel liner. Tantalum Cobalt Tungsten

  3. Heat exchanger life extension via in-situ reconditioning

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, David E.; Muralidharan, Govindarajan

    2016-06-28

    A method of in-situ reconditioning a heat exchanger includes the steps of: providing an in-service heat exchanger comprising a precipitate-strengthened alloy wherein at least one mechanical property of the heat exchanger is degraded by coarsening of the precipitate, the in-service heat exchanger containing a molten salt working heat exchange fluid; deactivating the heat exchanger from service in-situ; in a solution-annealing step, in-situ heating the heat exchanger and molten salt working heat exchange fluid contained therein to a temperature and for a time period sufficient to dissolve the coarsened precipitate; in a quenching step, flowing the molten salt working heat-exchange fluid through the heat exchanger in-situ to cool the alloy and retain a supersaturated solid solution while preventing formation of large precipitates; and in an aging step, further varying the temperature of the flowing molten salt working heat-exchange fluid to re-precipitate the dissolved precipitate.

  4. Lax operator algebras

    OpenAIRE

    Krichever, Igor M.; Sheinman, Oleg K.

    2007-01-01

    In this paper we develop a general concept of Lax operators on algebraic curves introduced in [1]. We observe that the space of Lax operators is closed with respect to their usual multiplication as matrix-valued functions. We construct the orthogonal and symplectic analogs of Lax operators, prove that they constitute almost graded Lie algebras and construct local central extensions of those Lie algebras.

  5. Full Life Cycle Research at the Ketzin Pilot Site, Germany - From Safe and Successful CO2 Injection Operation to Post-Injection Monitoring and Site Closure

    Science.gov (United States)

    Liebscher, A. H.

    2016-12-01

    The Ketzin pilot site near Berlin, Germany, was initiated in 2004 as the first European onshore storage project for research and development on geological CO2 storage. The operational CO2 injection period started in June 2008 and ended in August 2013 when the site entered the post-injection closure period. During these five years, a total amount of 67 kt of CO2 was safely injected into a saline aquifer (Upper Triassic sandstone) at a depth of 630 m - 650 m. In fall 2013, the first observation well was partially plugged in the reservoir section; full abandonment of this well finished in 2015 after roughly 2 years of well closure monitoring. Abandonment of the remaining 4 wells will be finished by 2017 and hand-over of liability to the competent authority is planned for end of 2017. The CO2 injected was mainly of food grade quality (purity > 99.9%). In addition, 1.5 kt of CO2 from the pilot capture facility "Schwarze Pumpe" (oxyfuel power plant CO2 with purity > 99.7%) was injected in 2011. The injection period terminated with a CO2-N2 co-injection experiment of 650 t of a 95% CO2/5% N2 mixture in summer 2013 to study the effects of impurities in the CO2 stream on the injection operation. During regular operation, the CO2 was pre-heated on-site to 40 - 45°C prior to injection to ensure a single-phase injection process and avoid any phase transition or transient states within the injection facility or the reservoir. Between March and July 2013, just prior to the CO2-N2 co-injection experiment, the injection temperature was stepwise decreased down to 10°C within a "cold-injection" experiment to study the effects of two-phase injection conditions. During injection operation, the combination of different geochemical and geophysical monitoring methods enabled detection and mapping of the spatial and temporal in-reservoir behaviour of the injected CO2 even for small quantities. After the cessation of CO2 injection, post-injection monitoring continued and two additional

  6. Extensibility in Model-Based Business Process Engines

    Science.gov (United States)

    Sánchez, Mario; Jiménez, Camilo; Villalobos, Jorge; Deridder, Dirk

    An organization’s ability to embrace change, greatly depends on systems that support their operation. Specifically, process engines might facilitate or hinder changes, depending on their flexibility, their extensibility and the changes required: current workflow engine characteristics create difficulties in organizations that need to incorporate some types of modifications. In this paper we present Cumbia, an extensible MDE platform to support the development of flexible and extensible process engines. In a Cumbia process, models represent participating concerns (control, resources, etc.), which are described with concern-specific languages. Cumbia models are executed in a coordinated way, using extensible engines specialized for each concern.

  7. Think - Baltic Extension / Kalle Kask

    Index Scriptorium Estoniae

    Kask, Kalle

    2002-01-01

    Tallinna TÜ Rehabilitatsiooni tehnoloogia keskus korraldas pressikonverentsi, kus tutvustati osalemist EL V raamprogrammis Think - Baltic Extension, mis on suunatud puuetega inimeste tööhõive tagamisele

  8. Think - Baltic Extension / Kalle Kask

    Index Scriptorium Estoniae

    Kask, Kalle

    2002-01-01

    Tallinna TÜ Rehabilitatsiooni tehnoloogia keskus korraldas pressikonverentsi, kus tutvustati osalemist EL V raamprogrammis Think - Baltic Extension, mis on suunatud puuetega inimeste tööhõive tagamisele

  9. Influence factors of sexual life in patients with cervical cancer after operation and nursing intervention%宫颈癌患者手术后性生活质量的影响因素及护理干预

    Institute of Scientific and Technical Information of China (English)

    杜云

    2013-01-01

    Objective To evaluate the influence factors of sexual life in patients with cervical cancer after operation and nursing intervention.Methods To analyse the factors affecting the quality of life in 172 cases of cervical cancer patients after operation and the nursing intervention.Results Age,treatment,family economic conditions,practitioners as well as the level of education is relevant factors affecting the postoperative sex; intervention group patients orgasm,sexual arousal of sexual desire,satisfaction,vaginal lubrication,pain,and sexual life times,and satisfaction were better than the control group (P < 0.05).Conclusions Age,treatment,family economic conditions,practitioners as well as the level of education is relevant factors affecting postoperative sexual life; nursing intervention can improve the postoperative quality of life of patients with cervical cancer.%目的 探讨宫颈癌患者手术后性生活质量的影响因素及护理干预措施.方法 对172例宫颈癌患者手术后性生活质量的影响因素进行分析,采用相应的护理干预措施.结果 年龄、治疗方式、家庭经济条件、从业情况以及文化程度是影响手术后性生活质量的相关因素,干预组患者的性高潮、性兴奋、性欲望、满意度、阴道润滑、疼痛、性生活次数以及满意度等均优于对照组(P<0.05).结论 年龄、治疗方式、家庭经济条件、从业情况以及文化程度是影响术后性生活的相关因素,护理干预可提高宫颈癌患者术后性生活质量.

  10. Prolongamento da vida pós-colheita de bananas-maçã submetidas ao 1-metilciclopropeno (1-MCP - qualidade sensorial e física Extension of postharvest life of 'Apple1 banana subjected to1-methylcyclopropene (1-MCP - sensory and physical quality

    Directory of Open Access Journals (Sweden)

    Ana Carla Marques Pinheiro

    2010-03-01

    Full Text Available Objetivou-se avaliar o efeito do 1-metilciclopropeno (1-MCP sobre a qualidade e extensão da vida pós-colheita de bananas-maçã. Frutas no grau 2 de coloração da casca foram tratadas com 50 nL.L-1 de 1-MCP durante 0 (controle, 6, 9, 12 e 24 horas. Posteriormente, foram armazenadas sob condição ambiente: 22± 2 ºC 85± 5% UR. Avaliaram-se as características sensoriais: aparência dos frutos no grau 4 (frutos mais verdes que amarelos e grau 7 (frutos amarelos com pontuações marrons de coloração da casca; descasque, aroma, sabor, firmeza da polpa e aspecto global nos frutos no grau 7, utilizando-se um teste de aceitabilidade através de escala hedônica de 9 pontos; e ainda a intenção de compra nos frutos nos graus 4 e 7, através de escala de 5 pontos. Avaliou-se também, visualmente, a extensão da vida pós-colheita, e, instrumentalmente, a coloração da casca e firmeza da polpa. Conclui-se que a aplicação de 50 nL.L-1 por um período de 12 horas é a mais adequada, pois promove extensão na vida pós-colheita de bananas-maçã, armazenadas em temperatura ambiente, em aproximadamente 11 dias, sem alterar a qualidade sensorial, a intenção de compra, coloração da casca e firmeza dos frutos quando maduros, comparados ao controle.The objective of this work was to evaluate the effect of 1-methylcyclopropene (1-MCP on the quality and extension of postharvest life of 'Apple1 banana. The fruit, at degree 2 of peel color was treated with 50 nL.L-1 of 1-MCP for 0 (control, 6, 9, 12 and 24 hours. Next, It was stored at room temperature: 22± 2 ºC 85± 5 per cent RH. The following sensory characteristics were evaluated: appearance of the fruit at degree 4 (greener than yellow and degree 7 (yellow with brown spots of peel color; peeling, aroma, flavor, firmness of pulp and global aspect of the fruit at degree 7, using a test of acceptability using the 9-point hedonic scale and also the intention of buying the fruit at degrees 4 and 7

  11. Fatigue life evaluation of a cracked pipeline pipe operating under variable; Estudo da vida em fadiga com variacao de pressao interna em tubos com defeitos

    Energy Technology Data Exchange (ETDEWEB)

    Betanzos, J.; Mattei, F. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil); Strohaecker, T. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Programa de Pos-graduacao em Engenharia de Minas, Metalurgia e Materiais; Marinho, R.; Hoppe, R.; Donato, G. [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2005-07-01

    Fatigue cracks in welded joints are commonly found in gas and oil pipelines and usually pumping is interrupted for repair. The strength of welded joints with defects, and consequently, the useful life of a pipeline, is an important information that could lead to great improvements in the reliability. To evaluate the working conditions determined by standards, specimens with 22'' diameter and 1/2'' wall thickness API 5L X60 pipes were used. Two semi-elliptical cracks were electro spark machined, with 50% and 25% of the tube wall thickness depths and a length/depth ratio of 1/20. Both defects were located in the HAZ of the tube longitudinal seam weld. Applying a cyclic internal pressure it was possible to propagate a fatigue crack until a through-thickness condition. The results show that the pressures to initiate crack propagation are too much higher than the pressures allowed by the standards for this kind of defect. (author)

  12. Applications and extensions of degradation modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, F.; Subudhi, M.; Samanta, P.K. (Brookhaven National Lab., Upton, NY (United States)); Vesely, W.E. (Science Applications International Corp., Columbus, OH (United States))

    1991-01-01

    Component degradation modeling being developed to understand the aging process can have many applications with potential advantages. Previous work has focused on developing the basic concepts and mathematical development of a simple degradation model. Using this simple model, times of degradations and failures occurrences were analyzed for standby components to detect indications of aging and to infer the effectiveness of maintenance in preventing age-related degradations from transforming to failures. Degradation modeling approaches can have broader applications in aging studies and in this paper, we discuss some of the extensions and applications of degradation modeling. The application and extension of degradation modeling approaches, presented in this paper, cover two aspects: (1) application to a continuously operating component, and (2) extension of the approach to analyze degradation-failure rate relationship. The application of the modeling approach to a continuously operating component (namely, air compressors) shows the usefulness of this approach in studying aging effects and the role of maintenance in this type component. In this case, aging effects in air compressors are demonstrated by the increase in both the degradation and failure rate and the faster increase in the failure rate compared to the degradation rate shows the ineffectiveness of the existing maintenance practices. Degradation-failure rate relationship was analyzed using data from residual heat removal system pumps. A simple linear model with a time-lag between these two parameters was studied. The application in this case showed a time-lag of 2 years for degradations to affect failure occurrences. 2 refs.

  13. Applications and extensions of degradation modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, F.; Subudhi, M.; Samanta, P.K. [Brookhaven National Lab., Upton, NY (United States); Vesely, W.E. [Science Applications International Corp., Columbus, OH (United States)

    1991-12-31

    Component degradation modeling being developed to understand the aging process can have many applications with potential advantages. Previous work has focused on developing the basic concepts and mathematical development of a simple degradation model. Using this simple model, times of degradations and failures occurrences were analyzed for standby components to detect indications of aging and to infer the effectiveness of maintenance in preventing age-related degradations from transforming to failures. Degradation modeling approaches can have broader applications in aging studies and in this paper, we discuss some of the extensions and applications of degradation modeling. The application and extension of degradation modeling approaches, presented in this paper, cover two aspects: (1) application to a continuously operating component, and (2) extension of the approach to analyze degradation-failure rate relationship. The application of the modeling approach to a continuously operating component (namely, air compressors) shows the usefulness of this approach in studying aging effects and the role of maintenance in this type component. In this case, aging effects in air compressors are demonstrated by the increase in both the degradation and failure rate and the faster increase in the failure rate compared to the degradation rate shows the ineffectiveness of the existing maintenance practices. Degradation-failure rate relationship was analyzed using data from residual heat removal system pumps. A simple linear model with a time-lag between these two parameters was studied. The application in this case showed a time-lag of 2 years for degradations to affect failure occurrences. 2 refs.

  14. Frames and extension problems I

    DEFF Research Database (Denmark)

    Christensen, Ole

    2014-01-01

    In this article we present a short survey of frame theory in Hilbert spaces. We discuss Gabor frames and wavelet frames and set the stage for a discussion of various extension principles; this will be presented in the article Frames and extension problems II (joint with H.O. Kim and R.Y. Kim)....

  15. Extension and the Practicing Veterinarian

    Science.gov (United States)

    Meyerholz, G. W.

    1974-01-01

    In order for Extension programs of veterinary medicine to succeed, good relationships are needed among university veterinarians, practicing local veterinarians, county Extension agents and the clientele. This author attempts to define some roles and relationships and offer some suggestions for the improvement of relationships to increase…

  16. An extension of heat hierarchy

    OpenAIRE

    Wang, Joe S.

    2014-01-01

    We propose a formally completely integrable extension of heat hierarchy based on the space of symmetries isomorphic to the Weyl algebra $\\mathcal{A}_1$. The extended heat hierarchy will be the basic model for the analysis of the extension of KP hierarchy, and other integrable equations.

  17. Extensive Reading Coursebooks in China

    Science.gov (United States)

    Renandya, Willy A.; Hu, Guangwei; Xiang, Yu

    2015-01-01

    This article reports on a principle-based evaluation of eight dedicated extensive reading coursebooks published in mainland China and used in many universities across the country. The aim is to determine the extent to which these coursebooks reflect a core set of nine second language acquisition and extensive reading principles. Our analysis shows…

  18. A Novel Active Network Architecture Based on Extensible Services Router

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Active networks are a new kind of packet-switched networks in which packets have code fragments that are executed on the intermediary nodes (routers). The code can extend or modify the foundation architecture of a network. In this paper, the authors present a novel active network architecture combined with advantages of two major active networks technology based on extensible services router. The architecture consists of extensible service router, active extensible components server and key distribution center (KDC). Users can write extensible service components with programming interface. At the present time, we have finished the extensible services router prototype system based on Highly Efficient Router Operating System (HEROS), active extensible components server and KDC prototype system based on Linux.

  19. Need for consent of a law extending the operating life of nuclear power plants; Zustimmungsbeduerftigkeit eines Gesetzes zur Verlaengerung der Laufzeiten von Kernkraftwerken

    Energy Technology Data Exchange (ETDEWEB)

    Degenhart, Christoph [Leipzig Univ. (Germany)

    2010-11-15

    The article deals with the question whether a law extending nuclear power plant life beyond the residual periods of time laid down in the law of April 22, 2002 requires consent of the Federal Council. The Atomic Energy Act needed the consent of the Federal Council pursuant to Article 87c, Basic Law, as its Section 24 determines that central functions of licensing and supervision be exercised by the federal states on behalf of the Federal Government. This has not changed after the current version of the norm. Increasing the residual quotas of electricity by amending Annex 3 of Sec.7, Para.1a, Atomic Energy Act, per se does not require consent. This is a substantive provision. Sec.24, Atomic Energy Act, does not need to be amended. The Federal Council, which consented to the original legislation, thus does not bear continued responsibility for the law. Every law must be treated as a separate entity in terms of legislative method. The Federal Council, with its first consent to the piece of legislation, ''approves'' this systemic shift. Renewed consent is required only in case of another systemic shift. This is the case when the provision about administrative responsibility takes on a very different meaning and impact no longer supported by the earlier consent. According to decisions by the Federal Constitutional Court, this expressly applies also to administration by commission. What is required is a comparison of administrative duties before and after entry into force of the amending law; mere quantitative shifts of administrative burdens do not cause a systemic shift. Whether the inclusion of backfitting obligations would be associated with regulations in administrative procedures has not been decided. In its ruling of May 4, 2010, the Federal Constitutional Court confirms that these do not require consent within the framework of Art.85 Para.1, Basic Law. (orig.)

  20. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 5: PEP environmental specification

    Science.gov (United States)

    1979-01-01

    This specification establishes the natural and induced environments to which the power extension package may be exposed during ground operations and space operations with the shuttle system. Space induced environments are applicable at the Orbiter attach point interface location. All probable environments are systematically listed according to each ground and mission phase.

  1. Hausdorff operators on Euclidean spaces

    Institute of Scientific and Technical Information of China (English)

    CHEN Jie-cheng; FAN Da-shan; WANG Si-lei

    2013-01-01

    Hausdorff operator is an important operator raised from the dilation on Euclidean space and rooted in the classical summability of number series and Fourier series. It is also connected to many well known operators in real and complex analysis. This article is a survey of some recent developments and extensions on the Hausdorff operator. Particularly, various boundedness properties of the Hausdorff operators, studied recently by our research group, are addressed.

  2. Cohomological vertex operators

    CERN Document Server

    Viña, Andrés

    2016-01-01

    Given a Calabi-Yau manifold and considering the $B$-branes on it as objects in the derived category of coherent sheaves, we identify the vertex operators for strings between two branes with elements of the cohomology groups of Ext sheaves. We define the correlation functions for these general vertex operators. Strings stretching between two coherent sheaves are studied as homological extensions of the corresponding branes. In this context, we relate strings between different pairs of branes when there are maps between these branes. We also interpret some strings with ghost number $k$ as obstructions for lifts or extensions of strings with ghost number $k-1$.

  3. Learning Joomla! 3 extension development

    CERN Document Server

    Plummer, Tim

    2013-01-01

    A practical guide with step-by-step examples that build on each other so you can learn by doing and get hands-on knowledge about creating your plugins, modules, and components in Joomla.""Learning Joomla! 3 Extension Development, Third Edition"" is for developers who want to create their own Joomla extensions. It is assumed you will have some basic PHP, HTML, and CSS knowledge, but you don't need any prior Joomla programming experience. This book will also be useful to people who just want to make minor customizations to existing Joomla extensions and build on the work of others in the open so

  4. Programming Reactive Extensions and LINQ

    CERN Document Server

    Liberty, Jesse

    2011-01-01

    Pro Reactive Extensions and LINQ is a deep dive into the next important technology for .NET developers: Reactive Extensions. This in-depth tutorial goes beyond what is available anywhere else to teach how to write WPF, Silverlight, and Windows Phone applications using the Reactive Extensions (Rx) to handle events and asynchronous method calls. Reactive programming allows you to turn those aspects of your code that are currently imperative into something much more event-driven and flexible. For this reason, it's sometimes referred to as LINQ for Events. Reactive programming hinges on the concep

  5. Evaluation of mechanical tractor pedal extensions.

    Science.gov (United States)

    Kelso, S A; Stangherlin, A M; Mann, D D

    2008-10-01

    Many farmers with disabilities choose to modify their work environments to accommodate their personal abilities; however, modified tractors may present greater risk to the operator as they are often one-of-a-kind designs that have not been subjected to rigorous safety testing. The objective of this research was to evaluate mechanical tractor pedal , extensions from a safety perspective. This objective was achieved by identifying potential hazards associated with the introduction of a pedal extension into the cab environment so that both existing and novel designs could be compared using a common methodology. Based on review of the published literature, 19 potential hazards associated with the introduction of a pedal extension into the cab of a tractor were identified. A hazard self-assessment worksheet (HSAW), created based on the 19 hazards, was validated through a pilot study. The overall inter-rater reliability and concurrent criterion validity proved to be acceptable. With the use of the HSAW six pedal extensions (three existing designs and three novel designs) were evaluated by 14 experts. Statistical analysis of the results did not identify a "best" design; however, several important trends were observed. Four of the six designs tended to block access to the exit path. The two designs that did not block access to the exit path might be considered to be the best designs for the tractors used in this study, but other designs likely would have been acceptable if they had been custom-fit for these tractors. The results of this research suggest that custom fabrication of pedal extensions for each specific tractor will likely yield the safest work environment for those who choose to use this assistive technology.

  6. Form Sums of Nonnegative Selfadjoint Operators

    NARCIS (Netherlands)

    Hassi, S.; Sandovici, A.; Snoo, H.S.V. de; Winkler, Henrik; Sandovici, 27740

    2006-01-01

    The sum of two unbounded nonnegative selfadjoint operators is a nonnegative operator which is not necessarily densely defined. In general its selfadjoint extensions exist in the sense of linear relations (multivalued operators). One of its nonnegative selfadjoint extensions is constructed via the fo

  7. An Improved Distortion Operator for Insurance Risks

    Institute of Scientific and Technical Information of China (English)

    GAO Jian-wei; QIU Wan-hua

    2002-01-01

    This paper reviews the distortion function approach developed in the actuarial literature for insurance risks. The main aim of this paper is to derive an extensive distortion operator, and to propose a new premium principle based on this extensive distortion operator. Furthermore, the non-robustness of general distortion operator is also discussed. Examples are provided using Bernoulli, Pareto, Lognormal and Gamma distribution assumptions.

  8. The Line Operations Safety Audit Program: Transitioning From Flight Operations to Maintenance and Ramp Operations

    Science.gov (United States)

    2011-09-01

    A Line Operations Safety Audit ( LOSA ) is a voluntary safety program that collects safety data during normal airline operations and was originally...maintenance and ramp operations. This report provides a review of the use of LOSA , discusses LOSA’s essential operating characteristics, lessons learned on...the flight deck, and describes the extension of LOSA to maintenance and ramp operations. The research team developed tools for airlines and

  9. Extension agents and conflict narratives

    DEFF Research Database (Denmark)

    Bond, Jennifer Lauren

    2016-01-01

    conflict. Originality: This work contributes to a growing body of literature interested in the role of extension agents in conflict management. By applying Q methodology, this work has shown that while extension agents are involved in conflict management, their perceptions of these conflicts are subjective......Purpose: This work investigated the narratives of development extensionists in relation to natural resource conflict, in order to understand the competing discourses surrounding the wicked problems of natural resource management in Laikipia County, Kenya. Methodology: Q methodology was used...... to elicit the conflict narratives present among extension professionals. A concourse of 221 statements were devised from interviews and group discussions with key informants and a final sample of 49 statements was used for the sorting. Thirteen Q-sorts were undertaken with among rural extension...

  10. Decentralizing Agricultural Extension: Alternative Strategies.

    Science.gov (United States)

    Rivera, William M.

    1997-01-01

    Examines government strategies for decentralizing agricultural extension, concluding that such changes are largely determined by the country's constitutional status. Reviews decentralization guidelines for structural and fiscal reforms and participatory management systems. (SK)

  11. Paths of Developing Trust Products of Life Insurance under the Mo de of Separated Operation%分业经营模式下人寿保险信托产品的发展途径

    Institute of Scientific and Technical Information of China (English)

    管延芳

    2016-01-01

    在分业经营模式下,人寿保险信托产品作为一种保险和信托组合的新产品悄然出现。从信托财产的角度分析了人寿保险信托产品的递进性及其共赢模式,针对人寿保险信托产品发展中存在的法律空白、兑付危机、教育短板、监管分立等问题,提出了制定并完善相关法律法规、提高信托机构内控水平、宣扬信托理念、调整监管体系等发展途径。%Under the mode of separate operation, trust products of life insurance as a kind of new products with combination of insur-ance and trust emerge quietly.This paper analyzes the progressive nature and the win-win model of trust products of life insurance from the angle of trust property, in view of problems existing in its development such as legal gaps, payment crisis, educational short board and separated supervision, it gives ways of improving regulatory, enhancing the internal control level of trust institution, advocating the concept of trust and adjusting regulatory system.

  12. 两种全盆底重建术后患者生活质量的初步研究%Clinical observation on quality of life of two different operative methods of total pelvic floor reconstruction

    Institute of Scientific and Technical Information of China (English)

    王红; 张晓红; 王建六

    2009-01-01

    Objective To compare patients' quality of life followed by Prolift operation and the revised total pelvic floor reconstruction with Gynemesh.Methods Thirty one patients underwent total pelvic floor reconstruction surgery were divided into two groups,including 14 cases treated by Prolift surgery and 17 cases treated by the revised total pelvic floor construction with Gynemesh.The body weight index(BWI),menopausal age and gravidity history did not show significant difference between two groups(P >0.05).The patients' age with 63±9 in Prolift group was significantly lower than 69±5 in Gynemesh group (P <0.05).Questionnair score of quality of life were collected and evaluated pre-and post-operation.Result (1) Preoperative scores:there was no significantly different scores of the following index between two groups (P >0.05),which were 91±42 in pelvic floor impact query,100±59 in pelvic floor distress query and 77±26 in sexual life query in Prolift group,65±56 in pelvic floor impact query,89±73 in pelvic floor distress query and 75±18 in sexual life query in Gynemesh group.(2) Postoperative scores:similarly,there was also no significantly different scores in the following index between two groups (P > 0.05),which were 7±15 in pelvic floor impact query,27±24 in pelvic floor distress query and 79±43 in sexual life query in Prolift group,13±24 in pelvic floor impact query,24±21 in pelvic floor distress query and 74±15 in sexual life query in Gynemesh group.Conclusions The patients' quality of life were improved after Prelift operation and the revised total pelvic floor construction with Gynemesh.However,about quality of sexual life,Prolift operation did much better than revised pelvic surgery with Gynemesh.%目的 观察两种全盆底重建术对患者生活质量的影响.方法 应用Prolift盆底悬吊系统行全盆底重建术14例(Prolift组),应用Gynemesh聚丙烯补片行改良全盆底重建术17例(Gynemesh组).两组患者体重指数、

  13. Review of progress in modelling for the assessment of the operating life of a nuclear power plant; Panorama des progres de la modelisation au service de la duree de vie des centrales

    Energy Technology Data Exchange (ETDEWEB)

    Monnier, B. [Electricite de France (EDF/RD), 78 - Chatou (France); Gilles, Ph. [FRAMATOME ANP, 92 - Paris-La-Defence (France); Chauliac, Ch. [CEA Saclay, Dir. de l' Energie Nucleaire DEN/DSOE, 91 - Gif sur Yvette (France)

    2004-07-01

    This article reviews the contributions of simulation and modelling to the assessment of the service life of a nuclear power plant. 4 aspects are considered. The first aspect concerns the operating life of the reactor vessel, in order to evaluate its aging a series of more or less intertwined modelling is necessary, they concern thermal-hydraulic transients, neutron fluences, damages due to irradiation and thermal-mechanical behaviour. The second aspect is the use of simulation to optimize non-destructive testing (NDT) particularly to assess the performances and limits of NDT methods in order to assure safety in any situation. The third aspect concerns the simulation of welding in order to assess the risk of defect occurrence, the pile-up of residual stresses and the feasibility of a complex welding. The last aspect is a global simulation of a nuclear unit as a whole involving its main components such as vessel, pumps, steam generators, turbine...; their maintenance, their failure risks in order to define indicator parameters that are relevant to the real state of the plant. (A.C.)

  14. Frames and extension problems II

    DEFF Research Database (Denmark)

    Christensen, Ole; Kim, Hong Oh; Kim, Rae Young

    2014-01-01

    This article is a follow-up on the article Frames and Extension Problems I. Here we will go into more recent progress on the topic and also present some open problems.......This article is a follow-up on the article Frames and Extension Problems I. Here we will go into more recent progress on the topic and also present some open problems....

  15. COCLEFT EXTENSIONS OF HOPF ALGEBRAS

    Institute of Scientific and Technical Information of China (English)

    祝家贵

    2006-01-01

    Let B and H be finitely generated projective Hopf algebras over a commutative ring R,with B cocommutative and H commutative. In this paper we investigate cocleft extensions of Hopf algebras, and prove that the isomorphism classes of cocleft Hopf algebras extensions of B by H are determined uniquely by the group C(B, H) = ZC(B, H)/d(B, H) .

  16. Preferred extensions as stable models

    OpenAIRE

    2008-01-01

    Given an argumentation framework AF, we introduce a mapping function that constructs a disjunctive logic program P, such that the preferred extensions of AF correspond to the stable models of P, after intersecting each stable model with the relevant atoms. The given mapping function is of polynomial size w.r.t. AF. In particular, we identify that there is a direct relationship between the minimal models of a propositional formula and the preferred extensions of an argumentation framework by w...

  17. COMPATIBLE EXTENSIONS OF FUZZY RELATIONS

    Institute of Scientific and Technical Information of China (English)

    Irina GEORGESCU

    2003-01-01

    In 1930 Szpilrajn proved that any strict partial order can be embedded in a strict linear order.This theorem was later refined by Dushnik and Miller (1941), Hansson (1968), Suzumura (1976),Donaldson and Weymark (1998), Bossert (1999). Particularly Suzumura introduced the important concept of compatible extension of a (crisp) relation. These extension theorems have an important role in welfare economics. In particular Szpilrajn theorem is the main tool for proving a known theorem of Richter that establishes the equivalence between rational and congruous consumers. In 1999 Duggan proved a general extension theorem that contains all these results. In this paper we introduce the notion of compatible extension of a fuzzy relation and we prove an extension theorem for fuzzy relations. Our result generalizes to fuzzy set theory the main part of Duggan's theorem. As applications we obtain fuzzy versions of the theorems of Szpilrajn, Hansson and Suzumura. We also prove that an asymmetric and transitive fuzzy relation has a compatible extension that is total, asymmetric and transitive.Our results can be useful in the theory of fuzzy consumers. We can prove that any rational fuzzyconsumer is congruous, extending to a fuzzy context a part of Richter's theorem. To prove that acongruous fuzzy consumer is rational remains an open problem. A proof of this result can somehowuse a fuzzy version of Szpilrajn theorem.

  18. 宫颈浸润癌患者术后性生活质量调查分析%Investigation and analysis on the quality of sexual life of patients with invasive cervical cancer after operation

    Institute of Scientific and Technical Information of China (English)

    陈美一; 李秀云; 马利国; 刘雪婧

    2011-01-01

    Objective: To investigate the change of quality of sexual life of patients with invasive cervical cancer after operation and the effect factors. Methods: 87 patients with invasive cervical cancer who received surgery in the hospital from January 2003 to January 2010 were surveyed by a questionnaire, QOL was used in the study, then the results were analyzed by t test, variance analysis and stepwise regression analysis. Results: After treatment, the quality of sexual life of patients with invasive cervical cancer decreased significantly, the effect factors included age, treatment modality, family financial situation, employment situation and educational level (P<0. 05) . Conclusion: The quality of sexual life of patients with invasive cervical cancer is affected by many factors, correct health education contributes to recovery of patients after operation.%目的:调查宫颈浸润癌术后患者性生活质量的变化及影响因素.方法:对2003年1月~2010年1月深圳市人民医院87例经手术治疗的宫颈浸润癌患者进行问卷调查,生字质量量表应用欧洲癌症研究和治疗机构的生存质量量表C30( EORTC QLQ - C30),结果应用t检验,方差分析及逐步回归分析.结果:宫颈癌患者治疗后性生活质量明显下降,影响患者性生活质量的因素包括:年龄、治疗方式、家庭经济、从业状况、文化程度(P<0.05).结论:宫颈癌患者性生活质量受多因素影响,正确的健康教育有助于患者术后性生活的恢复.

  19. Family Life Program Accountability Norms: How Do Your Results Compare?

    Science.gov (United States)

    Fetsch, Robert J.

    1997-01-01

    Participants in cooperative extension family life programs (N=916) identified family strains, coping, quality of life, self-esteem, stress, and willingness to support extension services with tax dollars. The resulting normative data can be used to measure the impact of cooperative extension programs. (SK)

  20. LIMB Demonstration Project Extension and Coolside Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Goots, T.R.; DePero, M.J.; Nolan, P.S.

    1992-11-10

    This report presents results from the limestone Injection Multistage Burner (LIMB) Demonstration Project Extension. LIMB is a furnace sorbent injection technology designed for the reduction of sulfur dioxide (SO[sub 2]) and nitrogen oxides (NO[sub x]) emissions from coal-fired utility boilers. The testing was conducted on the 105 Mwe, coal-fired, Unit 4 boiler at Ohio Edison's Edgewater Station in Lorain, Ohio. In addition to the LIMB Extension activities, the overall project included demonstration of the Coolside process for S0[sub 2] removal for which a separate report has been issued. The primary purpose of the DOE LIMB Extension testing, was to demonstrate the generic applicability of LIMB technology. The program sought to characterize the S0[sub 2] emissions that result when various calcium-based sorbents are injected into the furnace, while burning coals having sulfur content ranging from 1.6 to 3.8 weight percent. The four sorbents used included calcitic limestone, dolomitic hydrated lime, calcitic hydrated lime, and calcitic hydrated lime with a small amount of added calcium lignosulfonate. The results include those obtained for the various coal/sorbent combinations and the effects of the LIMB process on boiler and plant operations.

  1. Optimization of process operation to prolong service life of MTBE catalyst%优化工艺操作延长甲基叔丁基醚催化剂使用寿命

    Institute of Scientific and Technical Information of China (English)

    李军

    2016-01-01

    The factors affecting the service life of the catalyst for synthesis of methyl tert butyl ether(MTBE), such as metal ions,basic nitrogen compounds,water and C5 of the raw material,excess temperature and improper control of alfin ratio in operation,were introduced. In order to prolong the service life of the catalyst, the influencing factors were analyzed and the countermeasures were formulated. The catalyst operation cycle was prolonged from 695 days and 668 days to 928 days by strictly controlling the raw materials, increasing the replacement frequency of demineralized water of washing system,controlling the appropriate proportion of alfin ratio and appropriately enhancing reaction temperatures and so on;the high purity and conversion rate of MTBE product were ensured. The firm foundation for the long period operation of the device was laid.%介绍了原料中金属离子、碱性氮化物、水分、碳五以及操作中存在的超温和醇烯比控制不当等影响甲基叔丁基醚催化剂使用寿命的因素。为了达到延长催化剂使用寿命的目的,从影响因素进行分析并制定对策,通过对生产原料严格把关、增加水洗系统除盐水更换频次、控制合适醇烯比及适当升高反应温度等措施,将催化剂运行周期由之前的695天和668天提高至928天,并保证了较高的甲基叔丁基醚产品纯度和转化率,为装置的长周期运行打下坚实基础。

  2. Recent Life Assessment Technology for Existing Steam Turbines

    Science.gov (United States)

    Saito, Kiyoshi; Sakuma, Akira; Fukuda, Masataka

    A large and growing portion of electricity is produced by aging thermal power plants. Although excellent, high quality materials such as CrMoV steel and 12% Cr steel, etc. are used for the steam turbines, various forms of metallurgical degradation, due to creep and fatigue, etc. affect the parts and components during long-term operation at high temperature. Extending the life of steam turbines and ensuring high reliability requires life assessment technology, scheduled repairing, conversion, modification and upgrading of components in order to provide a stable power supply. As the high temperature parts and components of aged steam turbines are mainly metallurgically damaged by creep, fatigue and the interaction of both, life assessment combined with analytical and nondestructive methods is essential for realizing strategic plant life extension. We have developed a life assessment technology that takes material degradation into consideration, and have applied the procedure to more than 650 units and 2500 components since 1983. A rotor bore replication device was developed in 1989 for the purpose of nondestructive observation of creep voids and supporting the validity of life prediction results. This paper describes the technical features and applied experience of recent life assessment technology for existing high temperature steam turbines.

  3. Segment-specific adhesion as a driver of convergent extension.

    Directory of Open Access Journals (Sweden)

    Renske M A Vroomans

    2015-02-01

    Full Text Available Convergent extension, the simultaneous extension and narrowing of tissues, is a crucial event in the formation of the main body axis during embryonic development. It involves processes on multiple scales: the sub-cellular, cellular and tissue level, which interact via explicit or intrinsic feedback mechanisms. Computational modelling studies play an important role in unravelling the multiscale feedbacks underlying convergent extension. Convergent extension usually operates in tissue which has been patterned or is currently being patterned into distinct domains of gene expression. How such tissue patterns are maintained during the large scale tissue movements of convergent extension has thus far not been investigated. Intriguingly, experimental data indicate that in certain cases these tissue patterns may drive convergent extension rather than requiring safeguarding against convergent extension. Here we use a 2D Cellular Potts Model (CPM of a tissue prepatterned into segments, to show that convergent extension tends to disrupt this pre-existing segmental pattern. However, when cells preferentially adhere to cells of the same segment type, segment integrity is maintained without any reduction in tissue extension. Strikingly, we demonstrate that this segment-specific adhesion is by itself sufficient to drive convergent extension. Convergent extension is enhanced when we endow our in silico cells with persistence of motion, which in vivo would naturally follow from cytoskeletal dynamics. Finally, we extend our model to confirm the generality of our results. We demonstrate a similar effect of differential adhesion on convergent extension in tissues that can only extend in a single direction (as often occurs due to the inertia of the head region of the embryo, and in tissues prepatterned into a sequence of domains resulting in two opposing adhesive gradients, rather than alternating segments.

  4. Extensive fitness and human cooperation.

    Science.gov (United States)

    van Hateren, J H

    2015-12-01

    Evolution depends on the fitness of organisms, the expected rate of reproducing. Directly getting offspring is the most basic form of fitness, but fitness can also be increased indirectly by helping genetically related individuals (such as kin) to increase their fitness. The combined effect is known as inclusive fitness. Here it is argued that a further elaboration of fitness has evolved, particularly in humans. It is called extensive fitness and it incorporates producing organisms that are merely similar in phenotype. The evolvability of this mechanism is illustrated by computations on a simple model combining heredity and behaviour. Phenotypes are driven into the direction of high fitness through a mechanism that involves an internal estimate of fitness, implicitly made within the organism itself. This mechanism has recently been conjectured to be responsible for producing agency and goals. In the model, inclusive and extensive fitness are both implemented by letting fitness increase nonlinearly with the size of subpopulations of similar heredity (for the indirect part of inclusive fitness) and of similar phenotype (for the phenotypic part of extensive fitness). Populations implementing extensive fitness outcompete populations implementing mere inclusive fitness. This occurs because groups with similar phenotype tend to be larger than groups with similar heredity, and fitness increases more when groups are larger. Extensive fitness has two components, a direct component where individuals compete in inducing others to become like them and an indirect component where individuals cooperate and help others who are already similar to them.

  5. Second central extension in Galilean covariant field theory

    CERN Document Server

    Hagen, C R

    2002-01-01

    The second central extension of the planar Galilei group has been alleged to have its origin in the spin variable. This idea is explored here by considering local Galilean covariant field theory for free fields of arbitrary spin. It is shown that such systems generally display only a trivial realization of the second central extension. While it is possible to realize any desired value of the extension parameter by suitable redefinition of the boost operator, such an approach has no necessary connection to the spin of the basic underlying field.

  6. Nonlocal Operational Calculi for Dunkl Operators

    Directory of Open Access Journals (Sweden)

    Ivan H. Dimovski

    2009-03-01

    Full Text Available The one-dimensional Dunkl operator $D_k$ with a non-negative parameter $k$, is considered under an arbitrary nonlocal boundary value condition. The right inverse operator of $D_k$, satisfying this condition is studied. An operational calculus of Mikusinski type is developed. In the frames of this operational calculi an extension of the Heaviside algorithm for solution of nonlocal Cauchy boundary value problems for Dunkl functional-differential equations $P(D_ku = f$ with a given polynomial $P$ is proposed. The solution of these equations in mean-periodic functions reduces to such problems. Necessary and sufficient condition for existence of unique solution in mean-periodic functions is found.

  7. Preferred extensions as stable models

    CERN Document Server

    Nieves, Juan Carlos; Cortés, Ulises

    2008-01-01

    Given an argumentation framework AF, we introduce a mapping function that constructs a disjunctive logic program P, such that the preferred extensions of AF correspond to the stable models of P, after intersecting each stable model with the relevant atoms. The given mapping function is of polynomial size w.r.t. AF. In particular, we identify that there is a direct relationship between the minimal models of a propositional formula and the preferred extensions of an argumentation framework by working on representing the defeated arguments. Then we show how to infer the preferred extensions of an argumentation framework by using UNSAT algorithms and disjunctive stable model solvers. The relevance of this result is that we define a direct relationship between one of the most satisfactory argumentation semantics and one of the most successful approach of non-monotonic reasoning i.e., logic programming with the stable model semantics.

  8. Fish Culture Economics and Extension

    Directory of Open Access Journals (Sweden)

    E.N. Ogamba

    2012-12-01

    Full Text Available Fish culture economics and extension was reviewed to enable fish culturist plan effectively before involved in fish culture and practices. The cost and benefits of fish culture need be known before participation in the business. There is need for cross-link between research and the fishing community. Prior to introduction of any new innovation in fisheries extension and evaluation of such programmers, the agency responsible for such exercise should have full knowledge of the existing farming practice/techniques and the reasons behind them. In assessing or evaluating the impact of any new techniques or programmers, consideration should be given to such factors as natural conditions, local infrastructures, socio cultural setting, farmers’ production aims and labor economics. The study reviews the types of feasibility study, a typical feasibility study and report on a fish farm project and detail analysis of culture extension to enable fish culturist plan effectively before involved in fish culture and practices.

  9. On extensions of Leibniz algebras

    Science.gov (United States)

    Rakhimov, I. S.; Said Husain, Sh. K.; Mohammed, M. A.

    2017-09-01

    This paper is dedicated to the study extensions of Leibniz algebras using the annihilator approach. The extensions methods have been used earlier to classify certain classes of algebras. In the paper we first review and adjust theoretical background of the method for Leibniz algebras then apply it to classify four-dimensional Leibniz algebras over a field K. We obtain complete classification of four-dimensional nilpotent Leibniz algebras. The main idea of the method is to transfer the “base change” action to an action of automorphism group of the algebras of smaller dimension on cocycles constructed by the annihilator extensions. The method can be used to classify low-dimensional Leibniz algebras over other finite fields as well.

  10. Stable extensions by line bundles

    CERN Document Server

    Teixidor-i-Bigas, M

    1997-01-01

    Let C be an algebraic curve of genus g. Consider extensions E of a vector bundle F'' of rank n'' by a vector bundle F' of rank n'. The following statement was conjectured by Lange: If 0extensions like this with E stable. We prove this result for the generic curve when F' is a line bundle. Our method uses a degeneration argument to a reducible curve.

  11. MEMOS: a mobile extensible memory aid system.

    Science.gov (United States)

    Schulze, Hendrik

    2004-01-01

    Memory disturbances are a frequent outcome of brain damages. Maintenance or enhancement of the patients' quality of life requires enormous effort on the part of caregivers. To support patients with brain injuries, the mobile distributed care system named MEMOS (Mobile Extensible Memory System) was designed, implemented, and tested in the day-care clinic for cognitive neurology at Leipzig University. MEMOS is implemented as a distributed system, using CORBA technologies and Enterprise Java Beans. A special palmtop computer, the Personal Memory Assistant (PMA), reminds the patient of important tasks and supervises the patient's actions. The PMA communicates with the stationary care system via a bi-directional cellular radio connection. The stationary care system was developed to be dependable and scalable. This paper describes the design and function of the MEMOS system.

  12. Extension of Subjective Logic for Time- Related Trust

    Institute of Scientific and Technical Information of China (English)

    HUANG Chen-lin; HU Hua-ping

    2005-01-01

    To describe the dynamic property of trust relationship, we propose a time-related trust model and extend Josang's subjective logic to fit for time-related trust model.The extension includes propositional conjunction, disjunction and negation for traditional logic and discounting and consensus operators that are evidential operators specially designed for the propagation and computation of trust relationships.With the extension of subjective logic for time-related trust,our time-related trust model is suitable to model the dynamic trust relationship in practice. Finally an example of reputation assessment is offered to demonstrate the usage of our trust model.

  13. Parsing with Regular Expressions & Extensions to Kleene Algebra

    DEFF Research Database (Denmark)

    Grathwohl, Niels Bjørn Bugge

    . In the second part of this thesis, we study two extensions to Kleene algebra. Chomsky algebra is an algebra with a structure similar to Kleene algebra, but with a generalized mu-operator for recursion instead of the Kleene star. We show that the axioms of idempotent semirings along with continuity of the mu......-operator completely axiomatize the equational theory of the context-free languages. KAT+B! is an extension to Kleene algebra with tests (KAT) that adds mutable state. We describe a test algebra B! for mutable tests and give a commutative coproduct between KATs. Combining the axioms of B! with those of KAT and some...

  14. Modeling of useful operating life of radioelectronics

    Directory of Open Access Journals (Sweden)

    Nevlyudova V. V.

    2014-08-01

    Full Text Available The author considers the possibility of using the laws of nonequilibrium thermodynamics to determine the relationship between controlled parameters of radioelectronics and the displayed environment, as well as the construction of a deterministic model of the processes of manufacturing defects development. This possibility is based on the observed patterns of change in the amount of content area, in accordance with the principles of behavior of the thermodynamic parameters characterizing the state of the real environment (entropy, the quantity of heat, etc.. The equation for the evolution of the technical state of radioelectronics is based on the deterministic kinetic model of the processes occurring in the multi-component environment, and on the observation model, which takes into account the errors caused by external influences instability and uncertainty.

  15. Modeling of useful operating life of radioelectronics

    National Research Council Canada - National Science Library

    Nevlyudova V. V

    2014-01-01

    The author considers the possibility of using the laws of nonequilibrium thermodynamics to determine the relationship between controlled parameters of radioelectronics and the displayed environment...

  16. Intestinal ostomy's effect on patients' life quality of post-operation%肠造口术前定位对患者术后生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    梁惠兰; 李春梅; 陈锦坚; 孔群容; 郑小明; 邓顺华

    2014-01-01

    Objective To explore the effect of intestinal ostomy on patients' complications and life quality after operation.Methods We selected 60 patients among those who were in hospital and accepted intestinal ostomy from January to December 2013.Then we randomly divided them into two groups-experimental group and control group.The position of intestinal ostomy on patients' body in control group was decided by doctor during the operation after anesthesia while that on patients' body group in experimental group was determined by doctors,professional nurses and patients together.We compared these two groups for the differences in aspects of infection,complications happening rate,patients' self-care ability and life quality.Results The happening rate of complication in experimental group was obviously lower than that in control group and patients' self-care ability in experimental group was stronger than that in control group.Conclusion Locating the position of intestinal ostomy can decrease the happening rate of complication and improve patients' self-care ability and life quality after operation.%目的 探讨肠造口术前定位对患者术后并发症及生活质量的影响.方法 选择2013年1月至12月在我院住院行肠造口手术患者60例,随机分为实验组和对照组各30例.对照组肠造口位置由手术医生在手术室患者麻醉后术中定位;实验组肠造口位置在术前由手术医生、经过肠造口专业培训的肠造口专科护士及患者一起作肠造口定位标志.比较两组术后切口感染、造口旁疝、造口凹陷、造口粪漏等并发症的发生率及患者术后自我护理能力以及生活质量.结果 实验组切口感染、造口旁疝、造口凹陷、造口粪漏的发生率明显低于对照组(10.00% vs.33.33%),自我护理能力比对照组显著提高(100.00% vs.83.33%).结论 肠造口术前定位能降低患者肠造口术后并发症的发生率,提高患者日后长远的自我护理效果及术后生活质量.

  17. The validation of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30 in pre-operative patients with brain tumor in China

    Directory of Open Access Journals (Sweden)

    Zhang Hong-ying

    2011-04-01

    Full Text Available Abstract Background Health related quality of life (HRQOL has increasingly emphasized on cancer patients. The psychometric properties of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0 in brain tumor patients wasn't proven, and there was no baseline HRQOL in brain tumor patients prior to surgery. Methods The questionnaire EORTC QLQ-C30 (version 3.0 was administered at three time points: T1, the first or the second day that patients were hospitalized after the brain tumor suspected or diagnosed by MRI or CT; T2, 1 to 2 days after T1, (T1 and T2 were both before surgery; T3, the day before discharge. Clinical variables included disease histologic types, cognitive function, and Karnofsky Performance Status. Results Cronbach's alpha coefficients for multi-item scales were greater than .70 and multitrait scaling analysis showed that most of the item-scale correlation coefficients met the standards of convergent and discriminant validity, except for the cognitive functioning scale. All scales and items exhibited construct validity. Score changes over peri-operation were observed in physical and role functioning scales. Compared with mixed cancer patients assessed after surgery but before adjuvant treatment, brain tumor patients assessed pre-surgery presented better function and fewer symptoms. Conclusions The standard Chinese version of the EORTC QLQ-C30 was overall a valid instrument to assess HRQOL in brain tumor patients in China. The baseline HRQOL in brain tumor patients pre-surgery was better than that in mixed cancer patients post-surgery. Future study should modify cognitive functioning scale and examine test-retest reliability and response validity.

  18. Handbook of offshore oil and gas operations

    National Research Council Canada - National Science Library

    Speight, James G

    2015-01-01

    Handbook of Offshore Oil and Gas Operations is an authoritative source providing extensive up-to-date coverage of the technology used in the exploration, drilling, production, and operations in an offshore setting...

  19. Hamiltonian realizations of nonlinear adjoint operators

    NARCIS (Netherlands)

    Fujimoto, Kenji; Scherpen, Jacquelien M.A.; Gray, W. Steven

    2002-01-01

    This paper addresses the issue of state-space realizations for nonlinear adjoint operators. In particular, the relationships between nonlinear Hilbert adjoint operators, Hamiltonian extensions and port-controlled Hamiltonian systems are established. Then, characterizations of the adjoints of control

  20. Hamiltonian Realizations of Nonlinear Adjoint Operators

    NARCIS (Netherlands)

    Fujimoto, Kenji; Scherpen, Jacquelien M.A.; Gray, W. Steven

    2000-01-01

    This paper addresses state-space realizations for nonlinear adjoint operators. In particular the relationship among nonlinear Hilbert adjoint operators, Hamiltonian extensions and port-controlled Hamiltonian systems are clarified. The characterization of controllability, observability and Hankel ope