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Sample records for open pivot bi-leaflet

  1. Long-term outcomes following Medtronic Open Pivot valved conduit.

    Science.gov (United States)

    Naidoo, Rishendran; Pearse, Bronwyn; Tesar, Peter J; Yap, Su-Ann; Barnett, Adrian G; Fayers, Trevor

    2014-01-01

    Aortic root replacement is a complex procedure, though subsequent modifications of the original Bentall procedure have made surgery more reproducible. The study aim was to examine the outcomes of a modified Bentall procedure, using the Medtronic Open PivotTM valved conduit. Whilst short-term data on the conduit and long-term data on the valve itself are available, little is known of the long-term results with the valved conduit. Patients undergoing aortic root replacement between February 1999 and February 2010, using the Medtronic Open Pivot valved conduit were identified from the prospectively collected Cardiothoracic Register at The Prince Charles Hospital, Brisbane, Australia. All patients were followed up echocardiographically and clinically. The primary end-point was death, and a Cox proportional model was used to identify factors associated.with survival. Secondary end-points were valve-related morbidity (as defined by STS guidelines) and postoperative morbidity. Predictors of morbidity were identified using logistic regression. A total of 246 patients (mean age 50 years) was included in the study. The overall mortality was 12%, with actuarial 10-year survival 79% and a 10-year estimate of valve-related death of 0.04 (95% CI: 0.004, 0.07). Preoperative myocardial infarction (p = 0.004, HR 4.74), urgency of operation (p = 0.038, HR 2.8) and 10% incremental decreases in ejection fraction (p = 0.046, HR 0.69) were predictive of mortality. Survival was also affected by the valve gradients, with a unit increase in peak gradient reducing mortality (p = 0.021, HR 0.93). Valve-related morbidity occurred in 11 patients. Urgent surgery (p Medtronic Open Pivot valved conduit is a safe and durable option for aortic root replacement, and is associated with low morbidity and 10-year survival of 79%. However, further studies are required to determine the effect of valve gradient on survival.

  2. Laser Doppler anemometry measurements of steady flow through two bi-leaflet prosthetic heart valves

    Directory of Open Access Journals (Sweden)

    Ovandir Bazan

    2013-12-01

    Full Text Available INTRODUCTION: In vitro hydrodynamic characterization of prosthetic heart valves provides important information regarding their operation, especially if performed by noninvasive techniques of anemometry. Once velocity profiles for each valve are provided, it is possible to compare them in terms of hydrodynamic performance. In this first experimental study using laser doppler anemometry with mechanical valves, the simulations were performed at a steady flow workbench. OBJECTIVE: To compare unidimensional velocity profiles at the central plane of two bi-leaflet aortic prosthesis from St. Jude (AGN 21 - 751 and 21 AJ - 501 models exposed to a steady flow regime, on four distinct sections, three downstream and one upstream. METHODS: To provide similar conditions for the flow through each prosthesis by a steady flow workbench (water, flow rate of 17L/min. and, for the same sections and sweeps, to obtain the velocity profiles of each heart valve by unidimensional measurements. RESULTS: It was found that higher velocities correspond to the prosthesis with smaller inner diameter and instabilities of flow are larger as the section of interest is closer to the valve. Regions of recirculation, stagnation of flow, low pressure, and flow peak velocities were also found. CONCLUSIONS: Considering the hydrodynamic aspect and for every section measured, it could be concluded that the prosthesis model AGN 21 - 751 (RegentTM is superior to the 21 AJ - 501 model (Master Series. Based on the results, future studies can choose to focus on specific regions of the these valves.

  3. A biomimetic bi-leaflet mitral prosthesis with enhanced physiological left ventricular swirl restorative capability

    Science.gov (United States)

    Tan, Sean Guo-Dong; Kim, Sangho; Leo, Hwa Liang

    2016-06-01

    Mechanical heart valve prostheses are often implanted in young patients due to their durability and long-term reliability. However, existing designs are known to induce elevated levels of blood damage and blood platelet activation. As a result, there is a need for patients to undergo chronic anti-coagulation treatment to prevent thrombosis, often resulting in bleeding complications. Furthermore, recent studies have suggested that the implantation of a mechanical prosthetic valve at the mitral position results in a significant alteration of the left ventricular flow field which may contribute to flow turbulence. This study proposes a bi-leaflet mechanical heart valve design (Bio-MHV) that mimics the geometry of a human mitral valve, with the aim of reducing turbulence levels in the left ventricle by replicating physiological flow patterns. An in vitro three-dimensional particle velocimetry imaging experiment was carried out to compare the hemodynamic performance of the Bio-MHV with that of the clinically established ATS valve. The Bio-MHV was found to replicate physiological left ventricular flow patterns and produced lower turbulence levels.

  4. Effect of Opening the Sash of a Centre-Pivot Roof Window on Wind Pressure Coefficients

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Wigö, Hans; Heiselberg, Per

    2014-01-01

    This paper describes the effect of outward opening the sash of a window on local and overall wind pressures. Wind tunnel experiments were used for the purpose of evaluation. A centre-pivot roof window on a pitched roof in a modelled scaled building was used in the analysis of wind pressures...

  5. High-resolution fluid-structure interaction simulations of flow through a bi-leaflet mechanical heart valve in an anatomic aorta.

    Science.gov (United States)

    Borazjani, Iman; Ge, Liang; Sotiropoulos, Fotis

    2010-02-01

    We have performed high-resolution fluid-structure interaction simulations of physiologic pulsatile flow through a bi-leaflet mechanical heart valve (BMHV) in an anatomically realistic aorta. The results are compared with numerical simulations of the flow through an identical BMHV implanted in a straight aorta. The comparisons show that although some of the salient features of the flow remain the same, the aorta geometry can have a major effect on both the flow patterns and the motion of the valve leaflets. For the studied configuration, for instance, the BMHV leaflets in the anatomic aorta open much faster and undergo a greater rebound during closing than the same valve in the straight axisymmetric aorta. Even though the characteristic triple-jet structure does emerge downstream of the leaflets for both cases, for the anatomic case the leaflet jets spread laterally and diffuse much faster than in the straight aorta due to the aortic curvature and complex shape of the anatomic sinus. Consequently the leaflet shear layers in the anatomic case remain laminar and organized for a larger portion of the accelerating phase as compared to the shear layers in the straight aorta, which begin to undergo laminar instabilities well before peak systole is reached. For both cases, however, the flow undergoes a very similar explosive transition to the small-scale, turbulent-like state just prior to reaching peak systole. The local maximum shear stress is used as a metric to characterize the mechanical environment experienced by blood cells. Pockets of high local maximum shear are found to be significantly more widespread in the anatomic aorta than in the straight aorta throughout the cardiac cycle. Pockets of high local maximum shear were located near the leaflets and in the aortic arc region. This work clearly demonstrates the importance of the aortic geometry on the flow phenomena in a BMHV and demonstrates the potential of our computational method to carry out image

  6. Effect of Opening the Sash of a Centre-Pivot Roof Window on Wind Pressure Coefficients

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Wigö, Hans; Heiselberg, Per

    2014-01-01

    This paper describes the effect of outward opening the sash of a window on local and overall wind pressures. Wind tunnel experiments were used for the purpose of evaluation. A centre-pivot roof window on a pitched roof in a modelled scaled building was used in the analysis of wind pressures. The ...... pressure distribution nearby the window. The use of wind pressure coefficients from the analysis of sealed plain surface may lead to erroneous estimation of airflow rate.......This paper describes the effect of outward opening the sash of a window on local and overall wind pressures. Wind tunnel experiments were used for the purpose of evaluation. A centre-pivot roof window on a pitched roof in a modelled scaled building was used in the analysis of wind pressures....... The wind pressures were defined in terms of wind pressure coefficients. Traditionally wind pressure coefficients are extracted from the analysis of sealed plain surface. These wind pressure coefficients are used to estimate the natural ventilation rate through windows/openings due to wind effect. Surface...

  7. Twenty-year single-center experience with the medtronic open pivot mechanical heart valve.

    Science.gov (United States)

    Van Nooten, Guido J; Bové, Thierry; Van Belleghem, Yves; François, Katrien; Caes, Frank; Vandenplas, Guy; De Pauw, Michel; Taeymans, Yves

    2014-04-01

    Since May 1992 the Medtronic Open Pivot mechanical heart valve has been implanted routinely at the authors' institution. The study aim was to analyze, retrospectively, the 20-year clinical results of the valve. Between May 1992 and December 2011 a total of 1,520 valves was inserted into 1,382 consecutive patients (1,012 aortic, 473 mitral, 26 tricuspid, 9 pulmonary). The mean age of the patients was 61±13.2 years. Preoperatively, 65% of the patients were in New York Heart Association (NYHA) class III or greater. Frequent comorbidities included atrial fibrillation (n=419), coronary disease (n=357), and diabetes (n=255). The 99% complete follow-up totaled 10,527 patient-years (range 12 to 244 months). Ninety-day mortality was 5.2% (n=73, 8 valve related). Of the 550 total deaths, 240 were cardiac and 56 valve related. Multivariate analysis selected age, NYHA III or greater, concomitant coronary revascularization, and respiratory insufficiency as risk factors for death. Renal failure was considered a risk factor in the aortic and atrial fibrillation in the mitral subgroup. Erratic international normalized ratio (INR), NYHA class III or greater, and non-sinus rhythm were risk factors for thromboembolism; likewise redo operations in the aortic subgroup. Erratic INR and age were risk factors for bleeding as were over-coagulation and coronary revascularization in the aortic subgroup and redo operations and renal failure in mitral patients. This 20-year experience demonstrated excellent clinical outcomes with no structural valve failure. Odds ratio defined aortic patients as the lowest risk for adverse events. By contrast atrial fibrillation and elderly age, in combination with instable anticoagulation, yielded the worst long-term results. Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  8. Mid- to long-term outcome comparison of the Medtronic Hancock II and bi-leaflet mechanical aortic valve replacement in patients younger than 60 years of age: a propensity-matched analysis.

    Science.gov (United States)

    Wang, Yin; Chen, Si; Shi, Jiawei; Li, Geng; Dong, Nianguo

    2016-03-01

    This study aims to compare mid-long-term clinical outcomes between patients younger than 60 years of age undergoing bioprosthetic and mechanical aortic valve replacement. From January 2002 to December 2009, patients younger than 60 years of age who received Medtronic Hancock II porcine bioprostheses were selected and compared with those who received mechanical bi-leaflet valves in the aortic position. A stepwise logistic regression propensity score identified a subset of 112 evenly matched patient-pairs. Mid-long-term outcomes of survival, valve-related reoperations, thromboembolic events and bleeding events were assessed. The follow-up was only 95.1% complete. Fourteen measurable variables were statistically similar for the matched cohort. Postoperative in-hospital mortality was 3.6% (bioprosthetic valves) and 2.7% (mechanical valves) (P = 0.700). Survival at 5 and 10 years was 96.3 and 88.7% for patients receiving bioprosthetic valve replacement versus 96.3 and 87.9% for patients receiving mechanical valve replacement (P = 0.860), respectively. At 5 and 10 years after operations, freedom from valve-related reoperation was 97.2 and 94.8% for patients receiving mechanical valve replacement, and 96.3 and 90.2% for patients receiving bioprosthetic valve replacement (P = 0.296), respectively. There was no difference between freedom from thromboembolic events (P = 0.528) and bleeding events (P = 0.128) between the matched groups during the postoperative 10 years. In patients younger than 60 years of age undergoing aortic valve replacement, mid-long-term survival rate was similar for patients receiving bioprosthetic versus mechanical valve replacement. Bioprosthetic valves were associated with a trend for a lower risk of anticoagulation treatment and did not have significantly greater likelihood of a reoperation. These findings suggest that a bioprosthetic valve may be a reasonable choice for AVR in patients younger than 60 years of age. © The Author 2015. Published by

  9. Comprender: propuesta de pivotes

    Directory of Open Access Journals (Sweden)

    Santiago Alonso

    2011-06-01

    Full Text Available How do we understand? A pivot proposalThe basic question is what it is needed to understand. The proposal is that understanding requires pivots, a useful word to integrate findings in different areas. In that sense, a pivot can be understood as a mental model. It can also be the body, an idea based on embodied cognition. But more fundamentally, our biology and brain are the central pivots for understanding. Therefore, this essay can be seen as a brief travel through three different subjects: Mental Models, Embodied Cognition and Cognitive Neuroscience, all of which are necessary to understand how a person understands.

  10. HPC s Pivot to Data

    Energy Technology Data Exchange (ETDEWEB)

    Parete-Koon, Suzanne [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Caldwell, Blake A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Canon, Richard Shane [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Dart, Eli [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Sciences Network (ESnet); Hick, Jason [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Hill, Jason J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Layton, Chris [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Pelfrey, Daniel S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Shipman, Galen M [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Skinner, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Nam, Hai Ah [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Wells, Jack C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Zurawski, Jason [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Sciences Network (ESnet)

    2014-05-03

    Computer centers such as NERSC and OLCF have traditionally focused on delivering computational capability that enables breakthrough innovation in a wide range of science domains. Accessing that computational power has required services and tools to move the data from input and output to computation and storage. A ''pivot to data'' is occurring in HPC. Data transfer tools and services that were previously peripheral are becoming integral to scientific workflows. Emerging requirements from high-bandwidth detectors, high-throughput screening techniques, highly concur- rent simulations, increased focus on uncertainty quantification, and an emerging open-data policy posture toward published research are among the data-drivers shaping the networks, file systems, databases, and overall compute and data environment. In this paper we explain the pivot to data in HPC through user requirements and the changing resources provided by HPC with particular focus on data movement. For WAN data transfers we present the results of a study of network performance between centers.

  11. en los pivotes centrales

    Directory of Open Access Journals (Sweden)

    Reynaldo Roque Rodés

    2005-01-01

    Full Text Available Se hace una revisión y comentarios sobre las ventajas y limitantes del empleo del LEPA (Low Enery Precision Aplication en los sistemas de riego de pivotes centrales. Estos sistemas o filosofía de manejo del agua para condiciones de escasez o mala calidad del líquido es una alternativa viable para la producción de alimentos. Introducida en la década del 80 en las planicies del sur de Texas, donde la alta evaporación del agua y la necesidad de regar grandes áreas con pivotes centrales obligaba a la búsqueda de una alternativa para incrementar al máximo la eficiencia de aplicación del riego. Aún en fase de estudio e introducción en Cuba para áreas específicas, puede ser una solución de incremento de los rendimientos de los cultivos, empleando menos agua y aguas con calidad limitada

  12. Platelet activation through a Bi-leaflet mechanical heart valve

    Science.gov (United States)

    Hedayat, Mohammadali; Borazjani, Iman

    2016-11-01

    Platelet activation is one of the major drawbacks of the Mechanical Heart Valves (MHVs) which can increase the risk of thrombus formation in patients. The platelet activation in MHVs can be due to the abnormal shear stress during the systole, the backward leakage flow during the diastole, and the flow through the hinge region. We investigate the contribution of each of the above mechanism to the activation of platelets in MHVs by performing simulations of the flow through the MHV and in the hinge region. The large scale heart valve simulations are performed in a straight aorta using a sharp interface curvilinear immersed boundary method along with a strong-coupling algorithm under physiological flow conditions. In addition, in order to perform the simulation of hinge region the flow field boundary conditions are obtained from the largescale simulations during a whole cardiac cycle. In order to investigate the role of hinge flow on platelet activation in MHVs, a 23mm St. Jude Medical Regent valve hinge with three different gap sizes is tested along with different platelet activation models to ensure the consistency of our results with different activation models. We compare the platelet activation of the hinge region against the bulk of the flow during one cardiac cycle. This work is supported by the American Heart Association Grant 13SDG17220022, and the computational resources were partly provided by Center for Computational Research (CCR) at University at Buffalo.

  13. Analysis of Pivot Sampling in Dual-Pivot Quicksort

    DEFF Research Database (Denmark)

    Nebel, Markus E.; Wild, Sebastian; Martinez, Conrado

    2016-01-01

    The new dual-pivot Quicksort by Vladimir Yaroslavskiy—used in Oracle’s Java runtime library since version 7—features intriguing asymmetries. They make a basic variant of this algorithm use less comparisons than classic single-pivot Quicksort. In this paper, we extend the analysis to the case where...

  14. Low target-INR anticoagulation is safe in selected aortic valve patients with the Medtronic Open Pivot mechanical prosthesis: long-term results of a propensity-matched comparison with standard anticoagulation.

    Science.gov (United States)

    Bové, Thierry; Van Belleghem, Yves; François, Katrien; Caes, Frank; De Pauw, Michel; Taeymans, Yves; Van Nooten, Guido J

    2017-06-01

    To investigate the long-term results of a low international normalized ratio (INR)-anticoagulation program in selected patients after aortic valve replacement (AVR) with the Medtronic Open Pivot mechanical heart valve (OPMHV). From January 1993 to December 2012, 909 OPMHV valves were used for single AVR. Patients with preserved sinus rhythm and left ventricular function (Low-INR, n  = 552), were managed to an INR of 1.5-2.5 and compared to patients (Standard-INR, n  = 357) treated with standard anticoagulation (INR 2.5-3.5). Long-term outcome was analysed for survival and valve-related events, on propensity score matched pairs of 169 patients/group. Within a follow-up cumulating 3096 patient-years, 10- and 15-year survival was significantly better for Low-INR patients: 79% and 63% vs 63% and 34% ( P  < 0.001). Multivariate analysis of late mortality identified older age [odds ratio (OR) = 1.05], chronic pulmonary disease (OR = 1.90) and coronary artery disease (OR = 1.57) as patient-related risk factors, and erratic INR (OR = 2.57) as anticoagulation-related factor. The linearized thromboembolic rate was 0.72%/patient-year in Low-INR patients, vs 0.87%/patient-year in Standard-INR patients ( P  = 0.59), revealing INR variability as sole predictor (OR 3.54, 95% confidence interval (CI) 1.20-10.51, P  = 0.022). The linearized bleeding incidence was respectively 0.61%/patient-year and 1.21%/patient-year for Low-INR and Standard-INR patients ( P  = 0.04), retaining older age (OR 1.06, 95% CI 1.02-1.12, P  = 0.009), hypertension (OR 2.06, 95% CI 1.00-4.25, P  = 0.05) and erratic INR (OR 9.83, 95% CI 5.21-18.56, P  < 0.001) as independent risk factors. This study demonstrated that application of an anticoagulation regimen, aiming a low INR, individualized to selected aortic OPMHV patients, is safe and effective over more than 20 years, without increasing the thromboembolic complication rate while lowering the

  15. How Good Is Multi-Pivot Quicksort?

    DEFF Research Database (Denmark)

    Aumüller, Martin; Dietzfelbinger, Martin; Klaue, Pascal

    2016-01-01

    Multi-Pivot Quicksort refers to variants of classical quicksort where in the partitioning step k pivots are used to split the input into k + 1 segments. For many years, multi-pivot quicksort was regarded as impractical, but in 2009 a two-pivot approach by Yaroslavskiy, Bentley, and Bloch was chosen...... for multi-pivot quicksort are devised and analyzed. The analysis shows that the benefits of using multiple pivots with respect to the average comparison count are marginal and these strategies are inferior to simpler strategies such as the well-known median-of-k approach. A substantial part...

  16. Pivotal Response Treatment: Case Reports.

    Science.gov (United States)

    Ventola, Pamela; Friedman, Hannah; Oosting, Devon

    2015-01-01

    The current paper provides an overview of an evidence-based treatment, Pivotal Response Treatment (PRT), for autism spectrum disorder (ASD). The paper describes PRT principles and then illustrates the approach using two case reports. The children are preschool-aged children with high-functioning ASD. They were participating in a four-month clinical trial of PRT. At the start of treatment, they presented with significant social communication impairments, including a minimal understanding of reciprocity, limited play skills, and repetitive behaviors and speech. The paper outlines how behavioral treatment goals were identified and then how activities were designed, using principles of PRT, to target skill acquisition. Following the treatment course, both children made substantial and meaningful gains in social communication skill development.

  17. Extending Teach and Repeat to Pivoting Wheelchairs

    Directory of Open Access Journals (Sweden)

    Guillermo Del Castillo

    2003-02-01

    Full Text Available The paper extends the teach-and-repeat paradigm that has been successful for the control of holonomic robots to nonholonomic wheelchairs which may undergo pivoting action over the course of their taught movement. Due to the nonholonomic nature of the vehicle kinematics, estimation is required -- in the example given herein, based upon video detection of wall-mounted cues -- both in the teaching and the tracking events. In order to accommodate motion that approaches pivoting action as well as motion that approaches straight-line action, the estimation equations of the Extended Kalman Filter and the control equations are formulated using two different definitions of a nontemporal independent variable. The paper motivates the need for pivoting action in real-life settings by reporting extensively on the abilities and limitations of estimation-based teach-and-repeat action where pivoting and near-pivoting action is disallowed. Following formulation of the equations in the near-pivot mode, the paper reports upon experiments where taught trajectories which entail a seamless mix of near-straight and near-pivot action are tracked.

  18. Learning to Pivot with Adversarial Networks

    CERN Document Server

    Louppe, Gilles; Cranmer, Kyle

    2016-01-01

    Many inference problems involve data generation processes that are not uniquely specified or are uncertain in some way. In a scientific context, the presence of several plausible data generation processes is often associated to the presence of systematic uncertainties. Robust inference is possible if it is based on a pivot -- a quantity whose distribution is invariant to the unknown value of the (categorical or continuous) nuisance parameters that parametrizes this family of generation processes. In this work, we introduce a flexible training procedure based on adversarial networks for enforcing the pivotal property on a predictive model. We derive theoretical results showing that the proposed algorithm tends towards a minimax solution corresponding to a predictive model that is both optimal and independent of the nuisance parameters (if that models exists) or for which one can tune the trade-off between power and robustness. Finally, we demonstrate the effectiveness of this approach with a toy example and an...

  19. Single-sided natural ventilation through a centre-pivot roof window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Nielsen, Peter V.; Gunner, Amalie

    2014-01-01

    The characteristics of centre pivot roof windows for wind driven single-sided ventilation has not been studied before. These types of windows are dominating roof windows in Europe. Knowledge of flow characteristics of this kind of window is essential for accurate designing of natural ventilation...... systems. In this study, numerical methods were used to characterise a centre-pivot roof window for wind-driven single-sided ventilation. A 1:20 scale model house of the Energy Flex House (Denmark) was used in this study. The roof slope was 36o. It was found that the single-sided ventilation through...... the centre-pivot roof window can be characterised by a factor called the flow factor. The flow factor was a function of the sash opening-angle and wind direction. The flow factor increased with increase in opening-angle and decreased with increase in wind direction....

  20. Multi-Pivot Quicksort: an Experiment with Single, Dual, Triple, Quad, and Penta-Pivot Quicksort Algorithms in Python

    Science.gov (United States)

    Budiman, M. A.; Zamzami, E. M.; Rachmawati, D.

    2017-03-01

    Dual-pivot quicksort, which was proposed by Yaroslavsky, has been experimentally proven to be more efficient than the classical single-pivot quicksort under the Java Virtual Machine [6]. Moreover, Kushagara, López-Ortiz, and Munro [4] has shown that triple-pivot quicksort runs 7-8% faster than dual-pivot quicksort in C, mutatis mutandis. In this research, we implement and experiment with single, dual, triple, quad, and penta-pivot quicksort algorithms in Python. Our experimental results are as follows. Firstly, the quicksort with single pivot is the slowest among the five variants. Secondly, at least until five (penta) pivots are being used, it is proven that the more pivots are used in a quicksort algorithm, the faster its performance becomes. Thirdly, the increase of speed resulted by adding more pivots tends to decrease gradually.

  1. 76 FR 53425 - Pivotal LNG, Inc.; Notice of Application

    Science.gov (United States)

    2011-08-26

    ... Energy Regulatory Commission Pivotal LNG, Inc.; Notice of Application Take notice that on August 8, 2011, Pivotal LNG, Inc. (Pivotal), Ten Peachtree Place, Suite 1000, Atlanta, Georgia 30309, filed with the... transportation of natural gas as a by-product of the operation of non-jurisdictional liquefied natural gas...

  2. Sequential pivotal mechanisms for public project problems

    CERN Document Server

    Apt, Krzysztof R

    2008-01-01

    It is well-known that for several natural decision problems no budget balanced Groves mechanisms exist. This motivated recent research on designing variants of feasible Groves mechanisms (termed as `redistribution of VCG (Vickrey-Clarke-Groves) payments') that generate reduced deficit. With this in mind, we study sequential Groves mechanisms and consider optimal strategies that can lower the taxes that the players would have to pay under the simultaneous mechanism. We show that in the sequential pivotal mechanism for several variants of public project problems such strategies do exist. These strategies differ from truth-telling. In particular we exhibit an optimal strategy with the property that when each player follows it a maximal social welfare is generated.

  3. Intervention patterns of pivot nurses in oncology.

    Science.gov (United States)

    Skrutkowski, Myriam; Saucier, Andréanne; Ritchie, Judith A; Tran, Ngoc; Smith, Kevin

    2011-01-01

    The Pivot Nurse in Oncology (PNO) is a health care professional dedicated to providing patients with cancer and their families with continuing and consistent supportive care throughout the care trajectory. The purpose of this paper is to describe the variation and frequency of nursing interventions delivered by 12 PNOs at our health centre. An administrative analysis over a three-year period revealed a total of 43,906 interventions that were grouped into 10 categories. This analysis provided a description of the intervention frequency and these interventions were further collapsed into the four role functions of the PNO. Coordination/continuity of care and the assessment of needs and symptoms were identified as the dominant practice domains of the PNO in the professional cancer navigator role.

  4. Excel PivotTables and PivotCharts Your Visual Blueprint for Creating Dynamic Spreadsheets

    CERN Document Server

    McFedries, Paul

    2010-01-01

    Master two of the most powerful features of Excel. Even if you use Excel all the time, you may not be up to speed on two of Excel's most useful features. PivotTable and PivotChart turn long lists of unreadable data into dynamic, easy-to-read tables and charts that highlight the information you need most; you can tweak results with a click or easily fuse data from several sources into one document. Now you can learn how to tap these powerful Excel tools with this practical guide. Using a series of step-by-step tutorials and easy-to-follow screenshots, this book shows you in a visual way how to

  5. Pivotal Response Training. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2016

    2016-01-01

    This intervention report presents findings from a systematic review of "pivotal response training" conducted using the What Works Clearinghouse Procedures and Standards Handbook (version 3.0) and the Children and Students with an Autism Spectrum Disorder review protocol (version 3.0). "Pivotal response training"…

  6. The Discharge Coefficient of a Centre-Pivot Roof Window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Afshari, Alireza; Nielsen, Peter V.

    2012-01-01

    value of discharge coefficient is used. The constant value of discharge coefficient leads to deceptive airflow estimation in the cases of centre-pivot roof windows. The object of this paper is to study and evaluate the discharge coefficient of the centre pivot roof window. Focus is given...

  7. Graph reductions, binary rank, and pivots in gene assembly

    CERN Document Server

    Pflueger, Nathan

    2011-01-01

    In this paper, we describe a graph reduction operation, generalizing three combinatorial graph reduction rules related to gene assembly in ciliates. We study these reductions and their relation to the binary rank of a graph, which is the rank of the adjacency matrix over the finite field with two elements, and relate them to the graph pivot operation. We use these methods to solve two open problems posed by Harju, Li, and Petre regarding a graph formalization of gene assembly in ciliates. The graph formalization of gene assembly considers three reduction rules, called the positive, double, and negative rule, each of which removes one or two vertices from the graph. The graph reductions we define consist precisely of all compositions of these rules. We give algebraic criteria describing those subsets of vertices that can be removed by graph reductions, characterize the number of times the negative rule is applied to remove a given set of vertices, and show that such reductions are path invariant, in the sense ...

  8. Evaluating a Pivot-Based Approach for Bilingual Lexicon Extraction

    Directory of Open Access Journals (Sweden)

    Jae-Hoon Kim

    2015-01-01

    Full Text Available A pivot-based approach for bilingual lexicon extraction is based on the similarity of context vectors represented by words in a pivot language like English. In this paper, in order to show validity and usability of the pivot-based approach, we evaluate the approach in company with two different methods for estimating context vectors: one estimates them from two parallel corpora based on word association between source words (resp., target words and pivot words and the other estimates them from two parallel corpora based on word alignment tools for statistical machine translation. Empirical results on two language pairs (e.g., Korean-Spanish and Korean-French have shown that the pivot-based approach is very promising for resource-poor languages and this approach observes its validity and usability. Furthermore, for words with low frequency, our method is also well performed.

  9. Experimental analysis of single sided ventilation through a centre pivot roof window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Afshari, Alireza; Heiselberg, Per

    2015-01-01

    In the present study bidirectional airflow characteristics of a centre-pivot roof window were analysed in-situ. Both wind and temperature differences were present at the time of measurements. Tracer gas technique using N2O gas was used to estimate the air change rates in the experimental space....... Leakages through the experimental space were estimated using the blower door tests. Air-change rates increased with increase in the window sash opening angle. When the window was open all the way, with an average wind speed of 4 m/s, the average air-change rate was 2. Flow factor was used to characterise...

  10. Fiducial inference in the pivotal family of distributions

    Institute of Scientific and Technical Information of China (English)

    XU; Xingzhong; LI; Guoying

    2006-01-01

    In this paper a family, called the pivotal family, of distributions is considered.A pivotal family is determined by a generalized pivotal model. Analytical results show that a great many parametric families of distributions are pivotal. In a pivotal family of distributions a general method of deriving fiducial distributions of parameters is proposed. In the method a fiducial model plays an important role. A fiducial model is a function of a random variable with a known distribution, called the pivotal random element, when the observation of a statistic is given.The method of this paper includes some other methods of deriving fiducial distributions. Specially the first fiducial distribution given by Fisher can be derived by the method. For the monotone likelihood ratio family of distributions, which is a pivotal family, the fiducial distributions have a frequentist property in the Neyman-Pearson view. Fiducial distributions of regular parametric functions also have the above frequentist property. Some advantages of the fiducial inference are exhibited in four applications of the fiducial distribution. Many examples are given, in which the fiducial distributions cannot be derived by the existing methods.

  11. TIPOLOGI GRAMATIKAL DAN SISTEM PIVOT BAHASA PAKPAK-DAIRI

    Directory of Open Access Journals (Sweden)

    Ida Basaria

    2013-07-01

    The pivot testing shows that the deletion of a nominal phrase in PDL can be directly made if it functions as a subject or adverbial. If a nominal phrase functions as a predicate, the deletion cannot be directly made; one of the clauses must be made passive or topicalized first. Based on such a pattern, in can be concluded that PDL belongs to the accusative language typology with a pivot pattern of S/A.

  12. A NEW PRINCIPAL PIVOTING SCHEME FOR BOX LINEAR COMPLEMENTARITY PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    WANGZHEMIN

    1997-01-01

    Judice and Pires developed in recent years principal pivoting methods for the solving ofthe so-called box linear complementarity problems (BLCPs) where the constraint matrices are restrictedly supposed to be of P-matrices. This paper aims at presenting a new principal pivoting scheme for BLCPs where the constraint matrices are loosely supposed to be row sufficient. This scheme can be applied to the solving of convex quadratic programs subject to linear constraints and arbitrary upper and lower bound constraints on variables.

  13. Topic-aware pivot language approach for statistical machine translation

    Institute of Scientific and Technical Information of China (English)

    Jin-song SU; Xiao-dong SHI; Yan-zhou HUANG; Yang LIU; Qing-qiang WU; Yi-dong CHEN; Huai-lin DONG

    2014-01-01

    The pivot language approach for statistical machine translation (SMT) is a good method to break the resource bottleneck for certain language pairs. However, in the implementation of conventional approaches, pivot-side context information is far from fully utilized, resulting in erroneous estimations of translation probabilities. In this study, we propose two topic-aware pivot language approaches to use different levels of pivot-side context. The fi rst method takes advantage of document-level context by assuming that the bridged phrase pairs should be similar in the document-level topic distributions. The second method focuses on the effect of local context. Central to this approach are that the phrase sense can be refl ected by local context in the form of probabilistic topics, and that bridged phrase pairs should be compatible in the latent sense distributions. Then, we build an interpolated model bringing the above methods together to further enhance the system performance. Experimental results on French-Spanish and French-German translations using English as the pivot language demonstrate the effectiveness of topic-based context in pivot-based SMT.

  14. PowerPivot for advanced reporting and dashboards

    CERN Document Server

    Bosco, Robert

    2013-01-01

    A step-by-step tutorial with focused examples that builds progressively from basic to advanced topics and helps you create business intelligence reports and dashboards quickly and efficiently using the PowerPivot add-in.This book is ideal for data analysts, reporting and MIS professionals, business analysts, managers, dashboard makers, business intelligence professionals, self-service business intelligence personnel, and students. It is assumed that you have basic data analysis skills and intermediate level Excel skills. Familiarity with Pivot Tables as well as basic knowledge of VBA scripting

  15. Determination of kinetic energy applied by center pivot sprinklers

    Science.gov (United States)

    The kinetic energy of discrete drops impacting a bare soil surface is generally observed to lead to a drastic reduction in water infiltration rate due to soil surface seal formation. Under center pivot sprinkler irrigation, kinetic energy transferred to the soil prior to crop canopy development can...

  16. Droplet Kinetic Energy from Center-Pivot Sprinklers

    Science.gov (United States)

    The kinetic energy of discrete water drops impacting a bare soil surface is generally observed to lead to a drastic reduction in water infiltration rate due to soil surface seal formation. Under center-pivot sprinkler irrigation, kinetic energy transferred to the soil prior to crop canopy developmen...

  17. Classroom Pivotal Response Teaching for Children with Autism

    Science.gov (United States)

    Stahmer, Aubyn C.; Suhrheinrich, Jessica; Reed, Sarah; Schreibman, Laura; Bolduc, Cynthia

    2011-01-01

    This practical manual and accompanying DVD-ROM present a research-supported behavioral intervention for children with autism that teachers can easily integrate into their existing classroom curriculum. Classroom Pivotal Response Teaching (CPRT) enhances children's motivation and participation in learning; increases the number of learning…

  18. Pivotal Teaching Moments in Technology-Intensive Secondary Geometry Classrooms

    Science.gov (United States)

    Cayton, Charity; Hollebrands, Karen; Okumus, Samet; Boehm, Ethan

    2017-01-01

    This study investigates three teachers' uses of a dynamic geometry program (The Geometer's Sketchpad) in their high school geometry classes over a 2-year period. The researchers examine teachers' actions and questions during pivotal teaching moments to characterize mathematics instruction that utilizes technology. Findings support an association…

  19. Performance evaluation of a center pivot variable rate irrigation system

    Science.gov (United States)

    Variable Rate Irrigation (VRI) for center pivots offers potential to match specific application rates to non-uniform soil conditions along the length of the lateral. The benefit of such systems is influenced by the areal extent of these variations and the smallest scale to which the irrigation syste...

  20. Distraction osteogenesis with pivot plate in the treatment of scaphocephaly.

    Science.gov (United States)

    Nam, Seung Min; Kim, Yong Bae; Shin, Ho Seong; Park, Eun Soo; Jung, Sung Gyun

    2011-01-01

    In scaphocephaly, traditional distraction osteogenesis increases only the bitemporal width. We describe distraction osteogenesis with a pivot plate for scaphocephaly, which not only increases the bitemporal width but also decreases the anteroposterior length. Three patients with scaphocephaly were treated using distraction osteogenesis with a pivot plate between January 2005 and June 2006. These children underwent cranial reshaping by gradual distraction using an external distraction device and pivot plate. The distraction rate was 1 mm/d, and the latency period was 5 days. The follow-up period after distraction osteogenesis ranged from 16 to 24 months. No specific complications, such as accidental removal of the distraction devices, infection, or neurologic problems in any patient, occurred. The mean distraction was 45 mm. The mean cranial index was 73.6. Distraction osteogenesis for scaphocephaly is still in the development stage, but it is becoming accepted as a useful method because of its many advantages. Distraction osteogenesis with a pivot plate for scaphocephaly is better than other distraction osteogenesis techniques because it induces increased bitemporal width and decreased anteroposterior length synchronously.

  1. Remote pivot decoupler pylon: Wing/store flutter suppressor

    Science.gov (United States)

    Hassler, J. M., Jr. (Inventor)

    1986-01-01

    A device for suspending a store from an aerodynamic support surface, such an an aircraft wing, and more specifically, for improving upon singlet pivot decoupler pylons by reducing both frequency of active store, alignment, and alignment system space and power requirements. Two links suspend a lower pylon/rack section and releasable attached store from an upper pylon section mounted under the wing. The links allow the lower pylon section to rotate in pitch about a remote pivot point. A leaf spring connected between the lower section and electrical alignment system servomechanism provides pitch alignment of the lower section/store combination. The servomechanism utilizes an electric servomotor to drive the gear train and reversibly move the leaf spring, thereby maintaining the pitch attitude of the store within acceptable limits. The damper strokes when the lower section rotates to damp large oscillations of store.

  2. An Analysis and Implementation of a Parallel Ball Pivoting Algorithm

    Directory of Open Access Journals (Sweden)

    Julie Digne

    2014-07-01

    Full Text Available The problem of surface reconstruction from a set of 3D points given by their coordinates andoriented normals is a difficult problem, which has been tackled with many different approaches.In 1999, Bernardini and colleagues introduced a very elegant and efficient reconstruction methodthat uses a ball pivoting around triangle edges and adds new triangles if the ball is incidentto three points and contains no other points. This paper details an implementation and parallelization of this algorithm.

  3. Towards a pivotal-based approach for business process alignment

    OpenAIRE

    Ulmer, Jean-Stéphane; Belaud, Jean-Pierre; Le Lann, Jean-Marc

    2011-01-01

    This article focuses on business process engineering, especially on alignment between business analysis and implementation. Through a business process management approach, different transformations interfere with process models in order to make them executable. To keep the consistency of process model from business model to IT model, we propose a pivotal metamodel-centric methodology. It aims at keeping or giving all requisite structural and semantic data needed to perform such transformation...

  4. Gyroscope Pivot Bearing Dimension and Surface Defect Detection

    OpenAIRE

    2011-01-01

    Because of the perceived lack of systematic analysis in illumination system design processes and a lack of criteria for design methods in vision detection a method for the design of a task-oriented illumination system is proposed. After detecting the micro-defects of a gyroscope pivot bearing with a high curvature glabrous surface and analyzing the characteristics of the surface detection and reflection model, a complex illumination system with coaxial and ring lights is proposed. The illumin...

  5. New insights into muscle function during pivot feeding in seahorses.

    Directory of Open Access Journals (Sweden)

    Sam Van Wassenbergh

    Full Text Available Seahorses, pipefish and their syngnathiform relatives are considered unique amongst fishes in using elastic recoil of post-cranial tendons to pivot the head extremely quickly towards small crustacean prey. It is known that pipefish activate the epaxial muscles for a considerable time before striking, at which rotations of the head and the hyoid are temporarily prevented to allow energy storage in the epaxial tendons. Here, we studied the motor control of this system in seahorses using electromyographic recordings of the epaxial muscles and the sternohyoideus-hypaxial muscles with simultaneous high-speed video recordings of prey capture. In addition we present the results from a stimulation experiment including the muscle hypothesised to be responsible for the locking and triggering of pivot feeding in seahorses (m. adductor arcus palatini. Our data confirmed that the epaxial pre-activation pattern observed previously for pipefish also occurs in seahorses. Similar to the epaxials, the sternohyoideus-hypaxial muscle complex shows prolonged anticipatory activity. Although a considerable variation in displacements of the mouth via head rotation could be observed, it could not be demonstrated that seahorses have control over strike distance. In addition, we could not identify the source of the kinematic variability in the activation patterns of the associated muscles. Finally, the stimulation experiment supported the previously hypothesized role of the m. adductor arcus palatini as the trigger in this elastic recoil system. Our results show that pre-stressing of both the head elevators and the hyoid retractors is taking place. As pre-activation of the main muscles involved in pivot feeding has now been demonstrated for both seahorses and pipefish, this is probably a generalized trait of Syngnathidae.

  6. Pivotal Technology Research of Grid Based on Mobile Agent

    Institute of Scientific and Technical Information of China (English)

    CHEN Hong-wei; WANG Ru-chuan

    2004-01-01

    Grid Based on Mobile Agent is a new grid scheme. The purpose of the paper is to solve the pivotal technology of Grid Based on Mobile Agent ( GBMA) combined with thought of Virtual Organization ( VO). In GBMA, virtual organization is viewed as the basic management unit of the grid, and mobile agent is regarded as an important interactive means. Grid architecture, grid resource management and grid task management are the core technology problem of GBMA. The simulation results show that Inter- VO pattern has the obvious advantage because it can make full use of resources from other virtual organizations in GBMA environment.

  7. Gyroscope Pivot Bearing Dimension and Surface Defect Detection

    Directory of Open Access Journals (Sweden)

    Xudong Li

    2011-03-01

    Full Text Available Because of the perceived lack of systematic analysis in illumination system design processes and a lack of criteria for design methods in vision detection a method for the design of a task-oriented illumination system is proposed. After detecting the micro-defects of a gyroscope pivot bearing with a high curvature glabrous surface and analyzing the characteristics of the surface detection and reflection model, a complex illumination system with coaxial and ring lights is proposed. The illumination system is then optimized based on the analysis of illuminance uniformity of target regions by simulation and grey scale uniformity and articulation that are calculated from grey imagery. Currently, in order to apply the Pulse Coupled Neural Network (PCNN method, structural parameters must be tested and adjusted repeatedly. Therefore, this paper proposes the use of a particle swarm optimization (PSO algorithm, in which the maximum between cluster variance rules is used as fitness function with a linearily reduced inertia factor. This algorithm is used to adaptively set PCNN connection coefficients and dynamic threshold, which avoids algorithmic precocity and local oscillations. The proposed method is used for pivot bearing defect image processing. The segmentation results of the maximum entropy and minimum error method and the one described in this paper are compared using buffer region matching, and the experimental results show that the method of this paper is effective.

  8. Gyroscope pivot bearing dimension and surface defect detection.

    Science.gov (United States)

    Ge, Wenqian; Zhao, Huijie; Li, Xudong

    2011-01-01

    Because of the perceived lack of systematic analysis in illumination system design processes and a lack of criteria for design methods in vision detection a method for the design of a task-oriented illumination system is proposed. After detecting the micro-defects of a gyroscope pivot bearing with a high curvature glabrous surface and analyzing the characteristics of the surface detection and reflection model, a complex illumination system with coaxial and ring lights is proposed. The illumination system is then optimized based on the analysis of illuminance uniformity of target regions by simulation and grey scale uniformity and articulation that are calculated from grey imagery. Currently, in order to apply the Pulse Coupled Neural Network (PCNN) method, structural parameters must be tested and adjusted repeatedly. Therefore, this paper proposes the use of a particle swarm optimization (PSO) algorithm, in which the maximum between cluster variance rules is used as fitness function with a linearily reduced inertia factor. This algorithm is used to adaptively set PCNN connection coefficients and dynamic threshold, which avoids algorithmic precocity and local oscillations. The proposed method is used for pivot bearing defect image processing. The segmentation results of the maximum entropy and minimum error method and the one described in this paper are compared using buffer region matching, and the experimental results show that the method of this paper is effective.

  9. Wave Energy, Lever Operated Pivoting Float LOPF Study

    DEFF Research Database (Denmark)

    Margheritini, Lucia

    University in Denmark. The model size was 60cm W x 90cm L x 21cm H. The 60 cm width pointed towards the wave front. The LOPF buoy is characterized by a simple mechanical design with few moving parts and direct electrical output and it is taut moored to the sea bed, so all forces are referenced to the seabed......The fully instrumented Resen Waves Lever Operated Pivoting Float LOPF wave energy buoy model has gone through the first stage of testing in regular waves in scale 1:25 of the North Sea wave conditions, in the 3D deep wave basin at the Hydraulic and Coastal Engineering Laboratory of Aalborg...... for maximum energy output in regular as well as irregular waves. During storms the buoy pivots and streamlines itself to minimize loads on the mooring line. A conservative estimate shows that a full scale system for North Sea conditions has a float size width of 15 m that will, with 60% generator efficiency...

  10. Perturb and Observe Control for an Embedded Point Pivoted Absorber

    Directory of Open Access Journals (Sweden)

    Gianluca Brando

    2016-11-01

    Full Text Available Marine energy sources represent an attractive and inexhaustible reservoir able to contribute to the fulfillment of the world energy demand in accordance with climate/energy regulatory frameworks. Wave energy converter (WEC integration into the main grid requires both the maximization of the harvested energy and the proper management of the generation variability. The present paper focuses on both these mentioned issues. More specifically, it presents an embedded point pivoted absorber (PPA and its related control strategy aimed at maximizing the harvested energy. Experimental and numerical investigations have been carried out in a wave/towing tank facility in order to derive the design characteristics of the full-scale model and demonstrate the validity and effectiveness of the proposed control strategy.

  11. Astrocyte glutamine synthetase: pivotal in health and disease.

    Science.gov (United States)

    Rose, Christopher F; Verkhratsky, Alexei; Parpura, Vladimir

    2013-12-01

    The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis. GS (glutamine synthetase), which catalyses the ATP-dependent condensation of ammonia and glutamate to form glutamine, is an enzyme particularly found in astrocytes. GS plays a pivotal role in glutamate and glutamine homoeostasis, orchestrating astrocyte glutamate uptake/release and the glutamate-glutamine cycle. Furthermore, astrocytes bear the brunt of clearing ammonia in the brain, preventing neurotoxicity. The present review depicts the central function of astrocytes, concentrating on the importance of GS in glutamate/glutamine metabolism and ammonia detoxification in health and disease.

  12. Characteristics of pivotal trials and FDA review of innovative devices.

    Science.gov (United States)

    Rising, Joshua P; Moscovitch, Ben

    2015-01-01

    When patients lack sufficient treatment options for serious medical conditions, they rely on the prompt approval and development of new therapeutic alternatives, such as medical devices. Understanding the development of innovative medical devices, including the characteristics of premarket clinical trials and length of Food and Drug Administration (FDA) review, can help identify ways to expedite patient access to novel technologies and inform recent efforts by FDA to more quickly get these products to patients and physicians. We analyzed publicly available information on clinical trials and premarket FDA review for innovative medical devices that fill an unmet medical need. In this first-of-its-kind study focusing on these products, we extracted data on the length of the pivotal trials, primary study endpoint and FDA review; number of patients enrolled in trials; and in what country the device was available first. We identified 27 approved priority review devices from January 2006 through August 2013. The median duration of pivotal clinical trials was 3 years, ranging from 3 months to approximately 7 years. Trials had a median primary outcome measure evaluation time of one year and a median enrollment of 297 patients. The median FDA review time was 1 year and 3 months. Most priority review devices were available abroad before they were approved in the United States. Our study indicates that addressing the length of clinical studies--and contributing factors, such as primary outcome measures and enrollment--could expedite patient access to innovative medical devices. FDA, manufacturers, Congress and other stakeholders should identify the contributing factors to the length of clinical development, and implement appropriate reforms to address those issues.

  13. Characteristics of pivotal trials and FDA review of innovative devices.

    Directory of Open Access Journals (Sweden)

    Joshua P Rising

    Full Text Available When patients lack sufficient treatment options for serious medical conditions, they rely on the prompt approval and development of new therapeutic alternatives, such as medical devices. Understanding the development of innovative medical devices, including the characteristics of premarket clinical trials and length of Food and Drug Administration (FDA review, can help identify ways to expedite patient access to novel technologies and inform recent efforts by FDA to more quickly get these products to patients and physicians. We analyzed publicly available information on clinical trials and premarket FDA review for innovative medical devices that fill an unmet medical need. In this first-of-its-kind study focusing on these products, we extracted data on the length of the pivotal trials, primary study endpoint and FDA review; number of patients enrolled in trials; and in what country the device was available first. We identified 27 approved priority review devices from January 2006 through August 2013. The median duration of pivotal clinical trials was 3 years, ranging from 3 months to approximately 7 years. Trials had a median primary outcome measure evaluation time of one year and a median enrollment of 297 patients. The median FDA review time was 1 year and 3 months. Most priority review devices were available abroad before they were approved in the United States. Our study indicates that addressing the length of clinical studies--and contributing factors, such as primary outcome measures and enrollment--could expedite patient access to innovative medical devices. FDA, manufacturers, Congress and other stakeholders should identify the contributing factors to the length of clinical development, and implement appropriate reforms to address those issues.

  14. Wave energy, lever operated pivoting float LOPF study

    Energy Technology Data Exchange (ETDEWEB)

    Margheritini, L.

    2012-11-01

    The fully instrumented Resen Waves Lever Operated Pivoting Float LOPF wave energy buoy model has gone through the first stage of testing in regular waves in scale 1:25 of the North Sea wave conditions, in the 3D deep wave basin at the Hydraulic and Coastal Engineering Laboratory of Aalborg University in Denmark. The model size was 60cm W x 90cm L x 21cm H. The 60 cm width pointed towards the wave front. The LOPF buoy is characterized by a simple mechanical design with few moving parts and direct electrical output and it is taut moored to the sea bed, so all forces are referenced to the seabed for maximum energy output in regular as well as irregular waves. During storms the buoy pivots and streamlines itself to minimize loads on the mooring line. A conservative estimate shows that a full scale system for North Sea conditions has a float size width of 15 m that will, with 60% generator efficiency, produce 610 MWh/y (609.497 kWh/y) with an average power output of 69.6 kW, which requires a generator capacity of 700 kW. It is expected the generator efficiency can be increased to 90% in the future. More specific calculations (from EnergiNet) show that with one generator of 695 kW the expected power production is 585 MWh/y; with a generator of 250 kW and 100 kW, the expected power production is 481 MWh/y and 182 MWh/y respectively. In addition there are several areas for future improvements for increased power production. (Author)

  15. Novel and successful free comments method for sensory characterization of chocolate ice cream: A comparative study between pivot profile and comment analysis.

    Science.gov (United States)

    Fonseca, Fernando G A; Esmerino, Erick A; Filho, Elson R Tavares; Ferraz, Juliana P; da Cruz, Adriano G; Bolini, Helena M A

    2016-05-01

    Rapid sensory profiling methods have gained space in the sensory evaluation field. Techniques using direct analysis of the terms generated by consumers are considered easy to perform, without specific training requirements, thus improving knowledge about consumer perceptions on various products. This study aimed to determine the sensory profile of different commercial samples of chocolate ice cream, labeled as conventional and light or diet, using the "comment analysis" and "pivot profile" methods, based on consumers' perceptions. In the comment analysis task, consumers responded to 2 separate open questions describing the sensory attributes they liked or disliked in each sample. In the pivot profile method, samples were served in pairs (consisting of a coded sample and pivot), and consumers indicated the higher and lower intensity attributes in the target sample compared with the pivot. We observed that both methods were able to characterize the different chocolate ice cream samples using consumer perception, with high correlation results and configurational similarity (regression vector coefficient=0.917) between them. However, it is worth emphasizing that comment analysis is performed intuitively by consumers, whereas the pivot profile method showed high analytical and discriminative power even using consumers, proving to be a promising technique for routine application when classical descriptive methods cannot be used.

  16. HTML5 PivotViewer: high-throughput visualization and querying of image data on the web.

    Science.gov (United States)

    Taylor, Stephen; Noble, Roger

    2014-09-15

    Visualization and analysis of large numbers of biological images has generated a bottle neck in research. We present HTML5 PivotViewer, a novel, open source, platform-independent viewer making use of the latest web technologies that allows seamless access to images and associated metadata for each image. This provides a powerful method to allow end users to mine their data. Documentation, examples and links to the software are available from http://www.cbrg.ox.ac.uk/data/pivotviewer/. The software is licensed under GPLv2. © The Author 2014. Published by Oxford University Press.

  17. Pivotal results of the Medtronic Vascular Talent Thoracic Stent Graft System: the VALOR trial.

    Science.gov (United States)

    Fairman, Ronald M; Criado, Frank; Farber, Mark; Kwolek, Christopher; Mehta, Manish; White, Rodney; Lee, Anthony; Tuchek, J Michael

    2008-09-01

    This report summarizes the 30-day and 12-month results of endovascular treatment using the Medtronic Vascular Talent Thoracic Stent Graft System (Medtronic Vascular, Santa Rosa, Calif) for patients with thoracic aortic aneurysms (TAA) who are considered candidates for open surgical repair. The study was a prospective, nonrandomized, multicenter, pivotal trial conducted at 38 sites. Enrollment occurred between December 2003 and June 2005. Standard follow-up interval examinations were prescribed at 1 month, 6 months, 1 year, and annually thereafter. These endovascular results were compared with retrospective open surgical data from three centers of excellence. The Evaluation of the Medtronic Vascular Talent Thoracic Stent Graft System for the Treatment of Thoracic Aortic Aneurysms (VALOR) trial enrolled 195 patients, and 189 were identified as retrospective open surgical subjects. Compared with the open surgery group, the VALOR test group had similar age and sex distributions, but had a smaller TAA size. Patients received a mean number of 2.7 +/- 1.3 stent graft components. The diameters of 25% of the proximal stent graft components implanted were 40 mm. Left subclavian artery revascularization was performed before the initial stent graft procedure in 5.2% of patients. Iliac conduits were used in 21.1% of patients. In 33.5% of patients, the bare spring segment of the most proximally implanted device was in zones 1 or 2 of the aortic arch. In 194 patients (99.5%), vessel access and stent graft deployment were successful at the intended site. The 30-day VALOR results included perioperative mortality, 2.1%; major adverse advents, 41%; incidence of paraplegia, 1.5%; paraparesis, 7.2%; and stroke, 3.6%. The 12-month VALOR results included all-cause mortality, 16.1%; aneurysm-related mortality, 3.1%; conversion to open surgery, 0.5%; target aneurysm rupture, 0.5%; stent graft migration >10 mm, 3.9%; endoleak (12.2%), stent graft patency, 100%; stable or decreasing aneurysm

  18. Laboratory evaluation of the pivot-shift phenomenon with use of kinetic analysis: a preliminary study.

    Science.gov (United States)

    Sanchis-Alfonso, Vicente; Baydal-Bertomeu, José-María; Castelli, Andrea; Montesinos-Berry, Erik; Marín-Roca, Susana; Garrido-Jaén, José-David

    2011-07-06

    Currently, a suitable and reliable noninvasive method to evaluate rotational stability in vivo in anterior cruciate ligament-deficient knees, particularly during sports movements, does not exist. We speculated that if there is a rotational instability, the patient would avoid reaching a high pivoting moment during pivoting activities as a defense mechanism, and that the ground reaction moment, as registered by dynamometric platforms, would be reduced. On the basis of this hypothesis, we developed a study using kinetic analysis to evaluate rotational stability under dynamic loading. Thirty recreationally active athletes, including fifteen healthy subjects and fifteen with an anterior cruciate ligament-deficient knee, were recruited for this study. Patients performed jumping with pivoting with internal tibial rotation and external tibial rotation on the dynamometric platform with both the healthy and the injured limb. The quantitative results were graphically plotted, and the following parameters were evaluated: loading moment, pivoting moment, torque amplitude, loading slope, pivoting slope, percentage of pivoting with load, loading impulse, pivoting impulse, and maximum body rotation angle. There were no significant differences between the dominant and nondominant knees in the control group during the jumping with pivoting and external tibial rotation test with regard to the pivoting moment (p = 0.805), pivoting slope (p = 0.716), pivoting impulse 2 (p = 0.858), and pivoting impulse 3 (p = 0.873). In patients with a chronic tear of the anterior cruciate ligament, there was a significant decrease of the pivoting moment (p = 0.02), pivoting slope (p = 0.005), pivoting impulse 2 (p = 0.006), and pivoting impulse 3 (p = 0.035) during the jumping with pivoting and external tibial rotation test in the anterior cruciate ligament-deficient knee compared with the healthy, contralateral knee. Kinetic analysis with use of a dynamic platform can objectively detect alterations

  19. Plant hormone cross-talk: the pivot of root growth.

    Science.gov (United States)

    Pacifici, Elena; Polverari, Laura; Sabatini, Sabrina

    2015-02-01

    Root indeterminate growth and its outstanding ability to produce new tissues continuously make this organ a highly dynamic structure able to respond promptly to external environmental stimuli. Developmental processes therefore need to be finely tuned, and hormonal cross-talk plays a pivotal role in the regulation of root growth. In contrast to what happens in animals, plant development is a post-embryonic process. A pool of stem cells, placed in a niche at the apex of the meristem, is a source of self-renewing cells that provides cells for tissue formation. During the first days post-germination, the meristem reaches its final size as a result of a balance between cell division and cell differentiation. A complex network of interactions between hormonal pathways co-ordinates such developmental inputs. In recent years, by means of molecular and computational approaches, many efforts have been made aiming to define the molecular components of these networks. In this review, we focus our attention on the molecular mechanisms at the basis of hormone cross-talk during root meristem size determination. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  20. Pivot and cluster strategy: a preventive measure against diagnostic errors

    Directory of Open Access Journals (Sweden)

    Shimizu T

    2012-11-01

    Full Text Available Taro Shimizu,1 Yasuharu Tokuda21Rollins School of Public Health, Emory University, Atlanta, GA, USA; 2Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, JapanAbstract: Diagnostic errors constitute a substantial portion of preventable medical errors. The accumulation of evidence shows that most errors result from one or more cognitive biases and a variety of debiasing strategies have been introduced. In this article, we introduce a new diagnostic strategy, the pivot and cluster strategy (PCS, encompassing both of the two mental processes in making diagnosis referred to as the intuitive process (System 1 and analytical process (System 2 in one strategy. With PCS, physicians can recall a set of most likely differential diagnoses (System 2 of an initial diagnosis made by the physicians’ intuitive process (System 1, thereby enabling physicians to double check their diagnosis with two consecutive diagnostic processes. PCS is expected to reduce cognitive errors and enhance their diagnostic accuracy and validity, thereby realizing better patient outcomes and cost- and time-effective health care management.Keywords: diagnosis, diagnostic errors, debiasing

  1. BOMOD : management and development model for open data

    NARCIS (Netherlands)

    Eckartz, S.M.; Folmer, E.J.A.

    2015-01-01

    2014 was a pivotal year in the evolution of open data. For the first time, most governments participated in open data initiatives, making Open Data a world-wide known and accepted concept. In practice, however, both public and private organizations are struggling to recognize and realize the potenti

  2. Pivotal response treatment for autism spectrum disorder: current perspectives

    Directory of Open Access Journals (Sweden)

    Lei J

    2017-06-01

    Full Text Available Jiedi Lei, Pamela Ventola Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA Abstract: Pivotal response treatment (PRT is an evidence-based behavioral intervention based on applied behavior analysis principles aimed to improve social communication skills in individuals with autism spectrum disorder (ASD. PRT adopts a more naturalistic approach and focuses on using a number of strategies to help increase children’s motivation during intervention. Since its conceptualization, PRT has received much empirical support for eliciting therapeutic gains in greater use of functional social communication skills in individuals with ASD. Building upon the empirical evidence supporting PRT, recent advancements have increasingly turned to using interdisciplinary research integrating neuroimaging techniques and behavioral measures to help identify objective biomarkers of treatment, which have two primary purposes. First, neuroimaging results can help characterize how PRT may elicit change, and facilitate partitioning of the heterogeneous profiles of neural mechanisms underlying similar profile of behavioral changes observed over PRT. Second, neuroimaging provides an objective means to both map and track how biomarkers may serve as reliable and sensitive predictors of responder profiles to PRT, assisting clinicians to identify who will most likely benefit from PRT. Together, a better understanding of both mechanisms of change and predictors of responder profile will help PRT to serve as a more precise and targeted intervention for individuals with ASD, thus moving towards the goal of precision medicine and improving quality of care. This review focuses on the recent emerging neuroimaging evidences supporting PRT, offering current perspectives on the importance of interdisciplinary research to help clinicians better understand how PRT works and predict who will respond to PRT. Keywords: PRT, ASD, biomarkers, neuroimaging

  3. Strategic Pivot Toward the Asia-Pacific: Implications for USMC

    Science.gov (United States)

    2013-03-01

    participated: Belize, Canada, Colombia, Costa Rica , El Salvador, France, Guatemala, Honduras, the Netherlands, Nicaragua, Panama, Spain, United...for freedom of navigation and trade, South Korea for political clout and trade, the Philippines for trade and open 10 water fishing rights

  4. Automation of a center pivot using the temperature-time-threshold method of irriation scheduling

    Science.gov (United States)

    A center pivot was completely automated using the temperature-time-threshold (TTT) method of irrigation scheduling. An array of infrared thermometers was mounted on the center pivot and these were used to remotely determine the crop leaf temperature as an indicator of crop water stress. We describ...

  5. Pivotal behavior as the mediator of the relationship between parental responsiveness and children's symbolic behavior.

    Science.gov (United States)

    Chiu, Chun-Hao; Lin, Chu-Sui; Mahoney, Gerald; Cheng, Shu-Fen; Chang, Shu-Hui

    2017-08-01

    Previous research with parents and children with developmental disabilities indicated that the relationship between mothers' responsive style of interaction and children's rate of development was mediated by the simultaneous relationship between mothers' responsiveness and children's social engagement, or pivotal behavior. In this study, we attempted to determine whether children's pivotal behavior might also mediate the relationship between responsiveness and child development in a sample of 165 typically developing toddlers and their Taiwanese parents. Child development was assessed with a parent report measure of children's symbolic behavior. Parental responsiveness and children's pivotal behavior were assessed from observations of parent-child play. Results indicated that parental responsiveness was correlated with children's pivotal behavior, and that both of these variables were correlated with children's symbolic behavior. Structural equation models indicated that the relationship between responsiveness and children's symbolic behavior was fully mediated by children's pivotal behavior. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Hevin plays a pivotal role in corneal wound healing.

    Directory of Open Access Journals (Sweden)

    Shyam S Chaurasia

    with exogenous administration of rhHevin. Thus, hevin plays a pivotal role in the corneal wound healing.

  7. Pivotal results for the Medtronic Valiant Thoracic Stent Graft System in the VALOR II trial.

    Science.gov (United States)

    Fairman, Ronald M; Tuchek, J Michael; Lee, W Anthony; Kasirajan, Karthikeshwar; White, Rodney; Mehta, Manish; Lyden, Sean; Mukherjee, Dipankar; Bavaria, Joseph

    2012-11-01

    We report 30-day and 12-month results of endovascular treatment with the Valiant Thoracic Stent Graft System (Medtronic Vascular, Santa Rosa, Calif) in patients with descending thoracic aortic aneurysms of degenerative etiology. The Valiant stent graft is an evolution of the Talent thoracic stent graft (Medtronic Vascular). The VALOR II (Evaluation of the Clinical Performance of the Valiant Thoracic Stent Graft System in the Treatment of Descending Thoracic Aneurysms of Degenerative Etiology in Subjects Who Are Candidates for Endovascular Repair) was a prospective, nonrandomized, pivotal trial conducted at 24 U.S. sites with enrollment between December 2006 and September 2009. Standard follow-up examinations, including physical examination, computed tomography, and chest radiography, were at 1, 6, and 12 months, and annually through 5 years. VALOR II outcomes were compared with those from the pivotal VALOR (Evaluation of the Medtronic Vascular Talent Thoracic Stent Graft System for the Treatment of Thoracic Aortic Aneurysms) trial of the Talent stent graft, which enrolled 195 patients with similar enrollment criteria. VALOR II enrolled 160 patients. Compared with VALOR patients, VALOR II patients had similar age and sex distribution but higher rates of cardiovascular risk factors and significantly more severe modified Society for Vascular Surgery/American Association for Vascular Surgery risk scores. Stent graft delivery and deployment were successful in 154 patients (96.3%). Outcomes at 30 days in VALOR II were perioperative mortality, 3.1%; major adverse events, 38.1%; paraplegia, 0.6%; paraparesis, 1.9%; and stroke, 2.5%. At 12 months, after the minimum sample size was reached, 151 patients were evaluated: aneurysm-related mortality was 4.0%, stent graft migration was 2.9%, and endoleak was 13.0%. Through 12 months, there were no ruptures, conversions to open surgery, secondary procedures due to endoleak >30 days, or loss of stent graft patency. The Valiant

  8. 5G in Open-Pit Mines

    DEFF Research Database (Denmark)

    Portela Lopes de Almeida, Erika; Caldwell, George; Rodriguez Larrad, Ignacio

    2017-01-01

    5G will play a pivotal role in the digitization of the industrial sector and is expected to make the best use of every bit of spectrum available. In this light, this paper presents the results of an extensive measurement campaign in two iron-ore open-pit mining complexes, at the 700 MHz and 2.6 GHz...

  9. Efficiency of pivot splints as jaw exercise apparatus in combination with stabilization splints in anterior disc displacement without reduction: a retrospective study.

    Science.gov (United States)

    Muhtarogullari, Mehmet; Avci, Mehmet; Yuzugullu, Bulem

    2014-10-09

    To evaluate efficiency of pivot splints in jaw exercises, in combination with stabilization splints, in cases of anterior disc displacement without reduction of temporomandibular joint. Twenty-three patients who referred to the prosthodontics clinic in 1995-1997 were included in the study, where anterior disc displacement without reduction of temporomandibular joint was diagnosed using magnetic resonance imaging and clinical examination. Pivot splints were used for jaw exercises for five minutes long; five times/day and stabilization splints were used at all other times. The patients were followed for 24 weeks. Lateral and protrusive excursions along with maximum mouth opening and were evaluated at each control. Bilateral palpation of temporal, masseter, sternocleidomastoid muscles and TMJ was assessed for pain perception before and after treatment. Data were statistically analyzed using Paired sample t-test and Independent Samples t-test (p displacement without reduction; as normal mandibular range of motion was established and pain was eliminated.

  10. Pivotal response treatment for children with autism spectrum disorders: A systematic review

    NARCIS (Netherlands)

    Verschuur, R.; Didden, H.C.M.; Lang, R.; Sigafoos, J.; Huskens, B.E.B.M.

    2014-01-01

    Intervention studies evaluating pivotal response treatment (PRT) were systematically identified and analyzed. Forty-three studies were summarized in terms of (a) participant characteristics, (b) dependent variables, (c) intervention procedures, (d) intervention outcomes, and (e) certainty of evidenc

  11. 78 FR 66941 - Design Considerations for Pivotal Clinical Investigations for Medical Devices; Guidance for...

    Science.gov (United States)

    2013-11-07

    ... for Medical Devices; Guidance for Industry, Clinical Investigators, Institutional Review Boards and... entitled ``Design Considerations for Pivotal Clinical Investigations for Medical Devices.'' This document... premarket submissions for medical devices and for FDA staff who review those submissions. This...

  12. A study of shallow water’s effect on a ship’s pivot point

    Directory of Open Access Journals (Sweden)

    Jorge Enrique Carreño

    2012-12-01

    Full Text Available Information regarding a turning ship’s pivot point has been collected, taking practical notes and ship maneuvering manuals into account as well as experimental data and simulated results, together revealing consistent behaviour when varying water depth or some ship’s particulars. Results from studies already carried out using the Colombian Navy’s River Support Patrol Vessel (RSPV are included here to estimate the pivot point and contrast results with theory and available observations. Linear manoeuvrability theory was tested and the results revealed poor agreement with kinematic equations. As to the depth variation effect, full-scale experiments confirmed that the pivot point’s position, when in shallow water, always varied in the same way, thereby agreeing with available pivot point information.

  13. The Polynomial Pivots as Initial Values for a New Root-Finding Iterative Method

    Directory of Open Access Journals (Sweden)

    Mario Lázaro

    2015-01-01

    Full Text Available A new iterative method for polynomial root-finding based on the development of two novel recursive functions is proposed. In addition, the concept of polynomial pivots associated with these functions is introduced. The pivots present the property of lying close to some of the roots under certain conditions; this closeness leads us to propose them as efficient starting points for the proposed iterative sequences. Conditions for local convergence are studied demonstrating that the new recursive sequences converge with linear velocity. Furthermore, an a priori checkable global convergence test inside pivots-centered balls is proposed. In order to accelerate the convergence from linear to quadratic velocity, new recursive functions together with their associated sequences are constructed. Both the recursive functions (linear and the corrected (quadratic convergence are validated with two nontrivial numerical examples. In them, the efficiency of the pivots as starting points, the quadratic convergence of the proposed functions, and the validity of the theoretical results are visualized.

  14. A sustainable model for training teachers to use pivotal response training.

    Science.gov (United States)

    Suhrheinrich, Jessica

    2015-08-01

    The increase in the rate of autism diagnoses has created a growing demand for teachers who are trained to use effective interventions. The train-the-trainer model, which involves training supervisors to train others, may be ideal for providing cost-effective training and ongoing support to teachers. Although research supports interventions, such as pivotal response training, as evidence-based, dissemination to school environments has been problematic. This study assessed the benefits of using the train-the-trainer model to disseminate pivotal response training to school settings. A multiple-baseline design was conducted across three training groups, each consisting of one school staff member (trainer), three special education teachers, and six students. Trainers conducted the teacher-training workshop with high adherence to training protocol and met mastery criteria in their ability to implement pivotal response training, assess implementation of pivotal response training, and provide feedback to teachers. Six of the nine teachers mastered all components of pivotal response training. The remaining three teachers implemented 89% of the pivotal response training components correctly. The majority of trainers and teachers maintained their abilities at follow-up. These results support the use of the train-the-trainer model as an effective method of disseminating evidence-based practices in school settings. © The Author(s) 2014.

  15. Efficient Execution Methods of Pivoting for Bulk Extraction of Entity-Attribute-Value-Modeled Data.

    Science.gov (United States)

    Luo, Gang; Frey, Lewis J

    2016-03-01

    Entity-attribute-value (EAV) tables are widely used to store data in electronic medical records and clinical study data management systems. Before they can be used by various analytical (e.g., data mining and machine learning) programs, EAV-modeled data usually must be transformed into conventional relational table format through pivot operations. This time-consuming and resource-intensive process is often performed repeatedly on a regular basis, e.g., to provide a daily refresh of the content in a clinical data warehouse. Thus, it would be beneficial to make pivot operations as efficient as possible. In this paper, we present three techniques for improving the efficiency of pivot operations: 1) filtering out EAV tuples related to unneeded clinical parameters early on; 2) supporting pivoting across multiple EAV tables; and 3) conducting multi-query optimization. We demonstrate the effectiveness of our techniques through implementation. We show that our optimized execution method of pivoting using these techniques significantly outperforms the current basic execution method of pivoting. Our techniques can be used to build a data extraction tool to simplify the specification of and improve the efficiency of extracting data from the EAV tables in electronic medical records and clinical study data management systems.

  16. Woefzela - An open-source platform for ASR data collection in the developing world

    CSIR Research Space (South Africa)

    De Vries, NJ

    2011-08-01

    Full Text Available Building transcribed speech corpora for under-resourced languages plays a pivotal role in developing speech technologies for such languages. The authors have developed an open-source tool for devices running the Android operating system...

  17. Stress optimization of leaf-spring crossed flexure pivots for an active Gurney flap mechanism

    Science.gov (United States)

    Freire Gómez, Jon; Booker, Julian D.; Mellor, Phil H.

    2015-04-01

    The EU's Green Rotorcraft programme is pursuing the development of a functional and airworthy Active Gurney Flap (AGF) for a full-scale helicopter rotor blade. Interest in the development of this `smart adaptive rotor blade' technology lies in its potential to provide a number of aerodynamic benefits, which would in turn translate into a reduction in fuel consumption and noise levels. The AGF mechanism selected employs leaf-spring crossed flexure pivots. These provide important advantages over bearings as they are not susceptible to seizing and do not require maintenance (i.e. lubrication or cleaning). A baseline design of this mechanism was successfully tested both in a fatigue rig and in a 2D wind tunnel environment at flight-representative deployment schedules. For full validation, a flight test would also be required. However, the severity of the in-flight loading conditions would likely compromise the mechanical integrity of the pivots' leaf-springs in their current form. This paper investigates the scope for stress reduction through three-dimensional shape optimization of the leaf-springs of a generic crossed flexure pivot. To this end, a procedure combining a linear strain energy formulation, a parametric leaf-spring profile definition and a series of optimization algorithms is employed. The resulting optimized leaf-springs are proven to be not only independent of the angular rotation at which the pivot operates, but also linearly scalable to leaf-springs of any length, minimum thickness and width. Validated using non-linear finite element analysis, the results show very significant stress reductions relative to pivots with constant cross section leaf-springs, of up to as much as 30% for the specific pivot configuration employed in the AGF mechanism. It is concluded that shape optimization offers great potential for reducing stress in crossed flexure pivots and, consequently, for extending their fatigue life and/or rotational range.

  18. Giving raw data a chance to talk: a demonstration of exploratory visual analytics with a pediatric research database using Microsoft Live Labs Pivot to promote cohort discovery, research, and quality assessment.

    Science.gov (United States)

    Viangteeravat, Teeradache; Nagisetty, Naga Satya V Rao

    2014-01-01

    Secondary use of large and open data sets provides researchers with an opportunity to address high-impact questions that would otherwise be prohibitively expensive and time consuming to study. Despite the availability of data, generating hypotheses from huge data sets is often challenging, and the lack of complex analysis of data might lead to weak hypotheses. To overcome these issues and to assist researchers in building hypotheses from raw data, we are working on a visual and analytical platform called PRD Pivot. PRD Pivot is a de-identified pediatric research database designed to make secondary use of rich data sources, such as the electronic health record (EHR). The development of visual analytics using Microsoft Live Labs Pivot makes the process of data elaboration, information gathering, knowledge generation, and complex information exploration transparent to tool users and provides researchers with the ability to sort and filter by various criteria, which can lead to strong, novel hypotheses.

  19. Identifying and locating land irrigated by center-pivot irrigation systems using satellite imagery

    Science.gov (United States)

    Hoffman, R. O.

    1980-01-01

    A methodology for using Landsat imagery for the identification and location of land irrigated by center-pivot irrigation systems is presented. The procedure involves the use of sets of Landsat band 5 imagery taken separated in time by about three weeks during the irrigation season, a zoom transfer scope and mylar base maps to record the locations of center pivots. Further computer processing of the data has been used to obtain plots of center-pivot irrigation systems and tables indicating the distribution and growth of systems by county for the state of Nebraska, and has been found to be in 95% agreement with current high-altitude IR photography. The information obtainable can be used for models of ground-water aquifers or resource planning.

  20. Pivotal surfaces in inverse hexagonal and cubic phases of phospholipids and glycolipids.

    Science.gov (United States)

    Marsh, Derek

    2011-03-01

    Data on the location and dimensions of the pivotal surfaces in inverse hexagonal (H(II)) and inverse cubic (Q(II)) phases of phospholipids and glycolipids are reviewed. This includes the H(II) phases of dioleoyl phosphatidylethanolamine, 2:1 mol/mol mixtures of saturated fatty acids with the corresponding diacyl phosphatidylcholine, and glucosyl didodecylglycerol, and also the Q(II)(230/G) gyroid inverse cubic phases of monooleoylglycerol and glucosyl didodecylglycerol. Data from the inverse cubic phases are largely compatible with those from inverse hexagonal H(II)-phases. The pivotal plane is located in the hydrophobic region, relatively close to the polar-apolar interface. The area per lipid at the pivotal plane is similar in size to lipid cross-sectional areas found in the fluid lamellar phase (L(α)) of lipid bilayers. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  1. Steps towards commercialization of new power buoy with pivoting arm LOPF

    DEFF Research Database (Denmark)

    2013-01-01

    direct measurements from the model device are: voltage output, the torque on the generator, the arm bending moment produced by the mooring line and the absolute angle of the pivoting float. These allowed to follow the conversion of power in the power train from mechanic to electric power......The fully instrumented Lever Operated Pivoting Float LOPF wave energy buoy model has gone through the first stage of testing in regular waves in scale 1:25 of the North Sea wave conditions, in the 3D deep wave basin at the Hydraulic and Coastal Engineering Laboratory of Aalborg University. Some...

  2. Developing a Simple Unique Head-Discharge Equation for Pivot Weirs with Different Side Contractions

    Directory of Open Access Journals (Sweden)

    neda Sheikh Rezazadeh Nikou

    2016-10-01

    Full Text Available Introduction: Pivot weirs (sharp crested inclined weirs, Fig. 1-a is frequently used for discharge measurement, controlling water surface and flow diversion. Some typical features of pivot weirs are: (a overshot design for better water level control, (b Their application as head gates, turnout or check structure which requiring low head loss and high accuracy, (c ease of removing sediment deposit behind the weir, and (d ability to manage and monitor on-site or operating remotely when connected to a supervisory control and data acquisition (SCADA network. Kindsvater and Carter (8 derived a weir discharge equation based on energy and continuity equations. Hulsing (4 determined head-discharge relationship of inclined suppressed sharp crested weir with the slope of 3:3, 2:3 and 1:3 toward downstream and compared them with the equivalent normal sharp crested weir. In the USBR report on pivot weirs (regarding The Boulder Canyon Project,1948 the head discharge data of the suppressed pivot weir were presented in a channel with 5.5m length, 2.9m depth and 0.61m width. Some field experiments were also carried out in the IID (Imperial Irrigation District on a trapezoidal cross-section (0.61 m bottom width channel with pivot weir of 1.7m length, and two different widths of 1.63m. The flow rate (350-880 lit/s was held constant and different angles (15-50° calibrated instead of holding the angle constant and varying the flow rate. Some other laboratory tests were performed with Wahlin and Replogle (1994 on two pivot weirs with 1.2 m and 1.14 m width for the 0.61 m and 0.46 m length of blade and contraction factor of 0.925. RUBICON Company established an extensive operation on the application and automation of pivot weirs in irrigation channels in Australia (Www.rubicon.com. All previous studies concentrated on modifying the normal rectangular weir head-discharge equation so that it can be used for the pivot weirs. In this study, it is trying to derive a

  3. Excel Data Analysis your visual blueprint for creating and analyzing data, charts and PivotTables

    CERN Document Server

    Etheridge, Denise

    2010-01-01

    Advanced techniques for Excel power users. Crunch and analyze Excel data the way the professionals do with this clean, uncluttered, visual guide to advanced Excel techniques. Using numerous screenshots and easy-to-follow numbered steps, this book clearly shows you how to perform professional-level modeling, charting, data access, data slicing, and other functions. You'll find super techniques for getting the most out of Excel's statistical and financial functions, Excel PivotTables and PivotCharts, Excel Solver and BackSolver, and more.: Provides a clear look at power-using Excel, the world's

  4. Improvement of effective solid angle using virtual-pivot holder and large EDS detector.

    Science.gov (United States)

    Koshiya, Shogo; Kimoto, Koji

    2017-02-01

    This paper describes the effective solid angle improvement achieved using a large-area silicon drift detector together with a virtual-pivot double-tilt specimen holder. The virtual-pivot mechanism enables various designs of specimen-retaining and can reduce the shadowing effect. Energy-dispersive X-ray spectra were measured and converted into effective solid angles using different types of specimen holders and specimens. The investigated shadowing-free mechanical system yielded effective solid angles approaching the nominal solid angle of 0.464sr. In addition, we have demonstrated the availability of the plastic (polyetheretherketone) specimen holder for low system noise.

  5. Experimental Evaluation of the Discharge Coefficient of a Centre-Pivot Roof Window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Afshari, Alireza; Heiselberg, Per

    2013-01-01

    Windows are a component of naturally ventilated buildings. The scientific knowledge of how to estimate of airflow rates through windows is limited, especially in the case of centre-pivot roof windows. The flow through this type of windows is traditionally characterized by the orifice plate flow...... equation. This equation involves a discharge coefficient of the window. The value of the discharge coefficient is the major cause of erroneous estimation of airflow rates. This paper focuses on the experimental study of the discharge coefficient (CD) of a centre-pivot roof window. The measurements were...

  6. Using Pivotal Response Training and Technology to Engage Preschoolers with Autism in Conversations

    Science.gov (United States)

    Stockall, Nancy; Dennis, Lindsay R.

    2014-01-01

    It is well known that children with autism spectrum disorder (ASD) demonstrate a significant delay in language development that impacts their ability to engage in robust conversations. In this article the authors discuss two specific elements of pivotal response training--motivation and self-initiations--for children with ASD. Specific…

  7. Improving Question-Asking Initiations in Young Children with Autism Using Pivotal Response Treatment

    Science.gov (United States)

    Koegel, Robert L.; Bradshaw, Jessica L.; Ashbaugh, Kristen; Koegel, Lynn Kern

    2014-01-01

    Social initiations make up a core deficit for children with autism spectrum disorder (ASD). In particular, initiated questions during social interactions are often minimal or absent in this population. In the context of a multiple baseline design, the efficacy of using the motivational procedures of Pivotal Response Treatment to increase social…

  8. Pivotal Response Treatment for Children with Autism: Core Principles and Applications for School Psychologists

    Science.gov (United States)

    Renshaw, Tyler L.; Kuriakose, Sarah

    2011-01-01

    During the past 2 decades, pivotal response treatment (PRT) has emerged as an evidence-based methodology for intervening with the behavioral, communicative, social, and academic impairments of children with autism. Unlike other highly structured behavioral interventions for autism, PRT emphasizes principles over procedures and focuses on enhancing…

  9. Peer-Mediated Pivotal Response Treatment for Young Children with Autism Spectrum Disorders: A Systematic Review

    Science.gov (United States)

    Boudreau, Ainsley M.; Corkum, Penny; Meko, Katelyn; Smith, Isabel M.

    2015-01-01

    This review examined the effectiveness of peer-mediated pivotal response treatment (PM-PRT) to increase social-communication skills for children with autism spectrum disorders (ASD). A systematic review was conducted of all published studies examining PM-PRT in school-aged children with ASD, based on an established rubric. Five PM-PRT studies…

  10. Evaluation of water distribution under pivot irrigation systems using remote sensing imagery in eastern Nile delta

    Directory of Open Access Journals (Sweden)

    E. Farg

    2017-04-01

    Full Text Available Traditional methods for center pivot evaluation depend on the water depth distribution along the pivot arm. Estimation and mapping the water depth under pivot irrigation systems using remote sensing data is essential for calculating the coefficient of uniformity (CU of water distribution. This study focuses on estimating and mapping water depth using Landsat OLI 8 satellite data integrated with Heerman and Hein (1968 modified equation for center pivot evaluation. Landsat OLI 8 image was geometrically and radiometrically corrected to calculate the vegetation and water indices (NDVI and NDWI in addition to land surface temperature. Results of the statistical analysis showed that the collected water depth in catchment cans is also highly correlated negatively with NDVI. On the other hand water, depth was positively correlated with NDWI and LST. Multi-linear regression analysis using stepwise selection method was applied to estimate and map the water depth distribution. The results showed R2 and adjusted R2 0.93 and 0.88 respectively. Study area or field level verification was applied for estimation equation with correlation 0.93 between the collected water depth and estimated values.

  11. From Pivot to Symmetry Integrating Africa in the Rebalance to Asia

    Science.gov (United States)

    2014-02-13

    could be worse than any kind of pivot. Notes 1 Aaron Friedberg , "The Future of U.S.-China Relations: Is Conflict Inevitable... Friedberg , p. 7. 3 Stephen M. Walt, “Dealing With a Chinese Monroe Doctrine,” New York Times, 26 August 2013, http://www.nytimes.com/roomfordebate/2012/05

  12. Droplet kinetic energy of moving spray-plate center-pivot irrigation sprinklers

    Science.gov (United States)

    The kinetic energy of discrete water drops impacting a bare soil surface generally leads to a drastic reduction in water infiltration rate due to formation of a seal on the soil surface. Under center-pivot sprinkler irrigation, kinetic energy transferred to the soil prior to crop canopy development ...

  13. Characterizing droplet kinetic energy applied by moving spray-plate center pivot irrigation sprinklers

    Science.gov (United States)

    The kinetic energy of discrete drops impacting a bare soil surface is generally observed to lead to a drastic reduction in water infiltration rate due to soil surface seal formation. Under center pivot sprinkler irrigation, kinetic energy transferred to the soil prior to crop canopy development can...

  14. Neural Mechanisms of Improvements in Social Motivation after Pivotal Response Treatment: Two Case Studies

    Science.gov (United States)

    Voos, Avery C.; Pelphrey, Kevin A.; Tirrell, Jonathan; Bolling, Danielle Z.; Vander Wyk, Brent; Kaiser, Martha D.; McPartland, James C.; Volkmar, Fred R.; Ventola, Pamela

    2013-01-01

    Pivotal response treatment (PRT) is an empirically validated behavioral treatment that has widespread positive effects on communication, behavior, and social skills in young children with autism spectrum disorder (ASD). For the first time, functional magnetic resonance imaging was used to identify the neural correlates of successful response to…

  15. Subexponential lower bounds for randomized pivoting rules for the simplex algorithm

    DEFF Research Database (Denmark)

    Friedmann, Oliver; Hansen, Thomas Dueholm; Zwick, Uri

    2011-01-01

    The simplex algorithm is among the most widely used algorithms for solving linear programs in practice. With essentially all deterministic pivoting rules it is known, however, to require an exponential number of steps to solve some linear programs. No non-polynomial lower bounds were known, prior...

  16. Integration of wireless sensor networks into automatic irrigation scheduling of a center pivot

    Science.gov (United States)

    A six-span center pivot system was used as a platform for testing two wireless sensor networks (WSN) of infrared thermometers. The cropped field was a semi-circle, divided into six pie shaped sections of which three were irrigated manually and three were irrigated automatically based on the time tem...

  17. VERTICAL PROJECTION EFFICIENCY OF PIVOT POINTS USING ELECTRONIC TACHEOMETER DURING CONSTRUCTION OF BUILDINGS AND STRUCTURES

    Directory of Open Access Journals (Sweden)

    M. S. Nesterenok

    2014-01-01

    Full Text Available The paper shows that functional limitation of zenith devices and introduction of modern high-accuracy electronic tacheometers should lead to substitution of the mentioned devices for tacheometers in geodesic works concerning vertical projection of pivot points of the constructed buildings and structures. However the electronic tacheometer has not been considered in the function of a zenith device in ТКП 45-1.03-26-2006.Special experiemnts and practical works executed by UE “Geokart” has proved that in accordance with its design the electronic tacheometer equipped with a compensator for small inclinations and zenith prism attachment for ocular can be applied as a vertical projection device while setting sighting line of a telescope in a fixed vertical position. Corresponding experiments have been carried out for multi-storied building of business centre located in the M. Tank Street in Minsk in order to obtain comparative characteristics of vertical projection accuracy with the help of tacheometer TOPCON GPT 7501 and zenith device PZL-100. An initial point of the staked grid has been situated at the elevation ±0,0 м, standard graph elevation has been equal to +49,5 м (concrete slab of the 14th floor, projection height referred to the device has been equal to Н = 47,8 м. Both devices have been set on the same stand using a purpose made adaptive device in order to exclude centering errors. Deviation in position of final projection points on the standard graph which were obtained with the help of two devices has been equal to 1.2 mm, that testifies practical equal accuracy of the zenith device and tacheometer for vertical projection function.Additional advantage of the electronic tacheometer in comparison with special vertical projection devi ces lies in the fact that in the case of a certain misalignment of geodesic openings in intermediate floors ta- cheometer deviating from the vertical makes it possible to carry out initial point

  18. Efficient Storage and Querying of Horizontal Tables Using a PIVOT Operation in Commercial Relational DBMSs

    Science.gov (United States)

    Shin, Sung-Hyun; Moon, Yang-Sae; Kim, Jinho; Kim, Sang-Wook

    In recent years, a horizontal table with a large number of attributes is widely used in OLAP or e-business applications to analyze multidimensional data efficiently. For efficient storing and querying of horizontal tables, recent works have tried to transform a horizontal table to a traditional vertical table. Existing works, however, have the drawback of not considering an optimized PIVOT operation provided (or to be provided) in recent commercial RDBMSs. In this paper we propose a formal approach that exploits the optimized PIVOT operation of commercial RDBMSs for storing and querying of horizontal tables. To achieve this goal, we first provide an overall framework that stores and queries a horizontal table using an equivalent vertical table. Under the proposed framework, we then formally define 1) a method that stores a horizontal table in an equivalent vertical table and 2) a PIVOT operation that converts a stored vertical table to an equivalent horizontal view. Next, we propose a novel method that transforms a user-specified query on horizontal tables to an equivalent PIVOT-included query on vertical tables. In particular, by providing transformation rules for all five elementary operations in relational algebra as theorems, we prove our method is theoretically applicable to commercial RDBMSs. Experimental results show that, compared with the earlier work, our method reduces storage space significantly and also improves average performance by several orders of magnitude. These results indicate that our method provides an excellent framework to maximize performance in handling horizontal tables by exploiting the optimized PIVOT operation in commercial RDBMSs.

  19. Open access

    NARCIS (Netherlands)

    Valkenburg, P.M.

    2015-01-01

    Open access week Van 19 tot en met 25 oktober 2015 vond wereldwijd de Open Access Week plaats. Tijdens deze week werden er over de hele wereld evenementen georganiseerd waar open access een rol speelt. Ook in Nederland zijn er diverse symposia, workshops en debatten georganiseerd zoals het debat in

  20. The Pivot to Asia: Can It Serve as the Foundation for American Grand Strategy in the 21st Century

    Science.gov (United States)

    noting the growing importance of India and Chinas efforts to expand their influence into Central Asia, Europe, Africa , and Latin America. Dr. Stuart...complicated its efforts to keep its focus on the pivot strategy in the IAP region . He concludes with some lessons for strategists, derived from the Obama teams experience with the pivot.

  1. Two independent pivotal statistics that test location and misspecification and add-up to the Anderson-Rubin statistic

    NARCIS (Netherlands)

    Kleibergen, F.R.

    2002-01-01

    We extend the novel pivotal statistics for testing the parameters in the instrumental variables regression model. We show that these statistics result from a decomposition of the Anderson-Rubin statistic into two independent pivotal statistics. The first statistic is a score statistic that tests loc

  2. Mobile Technologies and Augmented Reality in Open Education

    Science.gov (United States)

    Kurubacak, Gulsun, Ed.; Altinpulluk, Hakan, Ed.

    2017-01-01

    Novel trends and innovations have enhanced contemporary educational environments. When applied properly, these computing advances can create enriched learning opportunities for students. "Mobile Technologies and Augmented Reality in Open Education" is a pivotal reference source for the latest academic research on the integration of…

  3. In Vitro Durability - Pivot bearing with Diamond Like Carbon for Ventricular Assist Devices

    CERN Document Server

    de Sá, Rosa Corrêa Leoncio; Leão, Tarcísio Fernandes; da Silva, Evandro Drigo; da Fonseca, Jeison Willian Gomes; da Silva, Bruno Utiyama; Leal, Edir Branzoni; Moro, João Roberto; de Andrade, Aron José Pazin; Bock, Eduardo Guy Perpétuo

    2015-01-01

    Institute Dante Pazzanese of Cardiology (IDPC) develops Ventricular Assist Devices (VAD) that can stabilize the hemodynamics of patients with severe heart failure before, during and/or after the medical practice; can be temporary or permanent. The ADV's centrifugal basically consist of a rotor suspended for system pivoting bearing; the PIVOT is the axis with movement of rotational and the bearing is the bearing surface. As a whole system of an implantable VAD should be made of long-life biomaterial so that there is no degradation or deformation during application time; surface modification techniques have been widely studied and implemented to improve properties such as biocompatibility and durability of applicable materials. The Chemical Vapour Deposition technique allows substrates having melting point higher than 300 {\\deg}C to be coated, encapsulated, with a diamond like carbon film (DLC); The test simulated the actual conditions in which the system of support remains while applying a ADV. The results hav...

  4. Pivotal temperature and sexual dimorphism of Podocnemis expansa hatchlings (Testudines: Podocnemididae from Bananal Island, Brazil

    Directory of Open Access Journals (Sweden)

    Adélio Lubiana

    2009-09-01

    Full Text Available A common problem when trying to identify the sex of hatchling turtles is that juveniles are not obviously externally dimorphic and current techniques to identify sex are often invasive. In this paper, 300 eggs of Podocnemis expansa from Bananal Island, state of Tocantins (Brazil, were incubated at constant temperatures. The carapaces of the hatchlings were photographed and subjected to geometric morphometric analysis. The hatchlings were subsequently euthanized and had their gonads removed for sex determination. The pivotal temperature of P. expansa was 33.5ºC, confirming that this species has the highest pivotal temperature among reptiles. Geometric morphometric analysis of the shape of the carapace proved efficient in differentiating the sex of the hatchlings and confirmed that this methodology can be efficient for studies that need to ascertain the sex ratio in P. expansa hatchlings.

  5. Safer and More Efficient Ship Handling with the Pivot Point Concept

    Directory of Open Access Journals (Sweden)

    Seong-Gi Seo

    2016-12-01

    Full Text Available The concept of the pivot point of a turning ship has been in existence for more than two centuries. It was not, however, properly understood from the beginning, and thus some misconceptions developed. This in turn caused it to be viewed as something mystical, thus preventing ship handling from scientific approach. The concept is expounded in a fresh light, deriving an equation for the definition and others for the calculation of the pivot point location both in general and for specific examples in an idealized condition. The implications of the derived equations are discussed. The results of a verification experiment are presented, which proved centuries’ of teachings and learnings to have been incorrect. A number of exercises for both steady and unsteady cases have been suggested for the training of the practitioners in the light of these new findings.

  6. One-year pivotal trial outcomes of the Nellix system for endovascular aneurysm sealing.

    Science.gov (United States)

    Carpenter, Jeffrey P; Cuff, Robert; Buckley, Clifford; Healey, Christopher; Hussain, Sajjad; Reijnen, Michel M P J; Trani, Jose; Böckler, Dittmar

    2017-02-01

    The Nellix EndoVascular Aneurysm Sealing (EVAS) System (Endologix, Inc, Irvine, Calif) is a novel approach to abdominal aortic aneurysm (AAA) treatment whereby polymer is used to fill the AAA sac. We report 1-year results of the investigational device exemption pivotal trial. Eligible patients were treated at 30 sites in the United States and Europe. Inclusion criteria required an asymptomatic infrarenal AAA, with a neck length ≥10 mm and ≤60° angle, iliac artery blood lumen diameter 9 to 35 mm, access artery diameter ≥6 mm, and serum creatinine ≤2 mg/dL. Follow-up included computed tomography angiography scans at 30 days, 6 months, and 1 year that were evaluated by a core laboratory. The primary safety end point was 30-day major adverse events (MAEs), which were compared with a performance goal of year, which was compared with a performance goal of >80%. Treatment success required procedural technical success and absence of AAA rupture during follow-up, conversion to open surgical repair, endoleak (type I or III) at 1 year, migration >10 mm causing complications or requiring secondary intervention, aneurysm enlargement, or secondary procedures through 1 year for resolution of endoleak, device obstruction or occlusion, or device defect. Of 150 treated patients, 149 (99.3%) completed 1-year follow-up. The MAEs rate at 30 days was 2.7% (95% confidence interval, 0.7%-6.7%), satisfying the primary safety end point (year treatment success was 94% (95% confidence interval, 88.6%-97.4%), achieving the primary effectiveness end point (>80%). At 1 year, key secondary outcomes included 6.7% MAEs, 4.7% serious device-related events, 1.3% AAA-related mortality, 3.7% secondary interventions, and 0.7% surgical conversions. MAEs through 1 year included death (n = 6), stroke (n = 3), bowel ischemia (n = 2), renal failure (n = 2), respiratory failure (n = 2), and myocardial infarction (n =1). One iatrogenic AAA rupture occurred and one AAA rupture

  7. U.S.“Pivot to Asia" Faces Numerous Problems Ahead

    Institute of Scientific and Technical Information of China (English)

    Hong; Yuan

    2014-01-01

    <正>It is generally believed that U.S.pivot to Asia or the rebalancing in Asia-Pacific derives from its psychology,which is more fear of China’s rise than China’s wish to challenge America.So far there is no effective evidence showing that China is challenging the United States,but fear of China can be seen everywhere in the United States.Therefore,the biggest global objective of the United States is

  8. The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload

    OpenAIRE

    Masataka Ikeda; Tomomi Ide; Takeo Fujino; Yuka Matsuo; Shinobu Arai; Keita Saku; Takamori Kakino; Yasuhiro Oga; Akiko Nishizaki; Kenji Sunagawa

    2015-01-01

    The heart has two major modalities of hypertrophy in response to hemodynamic loads: concentric and eccentric hypertrophy caused by pressure and volume overload (VO), respectively. However, the molecular mechanism of eccentric hypertrophy remains poorly understood. Here we demonstrate that the Akt-mammalian target of rapamycin (mTOR) axis is a pivotal regulator of eccentric hypertrophy during VO. While mTOR in the heart was activated in a left ventricular end-diastolic pressure (LVEDP)-depende...

  9. Time-Resolved Micro PIV in the Pivoting Area of the Triflo Mechanical Heart Valve.

    Science.gov (United States)

    Vennemann, Bernhard M; Rösgen, Thomas; Carrel, Thierry P; Obrist, Dominik

    2016-09-01

    The Lapeyre-Triflo FURTIVA valve aims at combining the favorable hemodynamics of bioprosthetic heart valves with the durability of mechanical heart valves (MHVs). The pivoting region of MHVs is hemodynamically of special interest as it may be a region of high shear stresses, combined with areas of flow stagnation. Here, platelets can be activated and may form a thrombus which in the most severe case can compromise leaflet mobility. In this study we set up an experiment to replicate the pulsatile flow in the aortic root and to study the flow in the pivoting region under physiological hemodynamic conditions (CO = 4.5 L/min / CO = 3.0 L/min, f = 60 BPM). It was found that the flow velocity in the pivoting region could reach values close to that of the bulk flow during systole. At the onset of diastole the three valve leaflets closed in a very synchronous manner within an average closing time of 55 ms which is much slower than what has been measured for traditional bileaflet MHVs. Hot spots for elevated viscous shear stresses were found at the flanges of the housing and the tips of the leaflet ears. Systolic VSS was maximal during mid-systole and reached levels of up to 40 Pa.

  10. Plant responses, climate pivot points, and trade-offs in water-limited ecosystems

    Science.gov (United States)

    Munson, Seth M.

    2013-01-01

    Plant species in dryland ecosystems are limited by water availability and may be vulnerable to increases in aridity. Methods are needed to monitor and assess the rate of change in plant abundance and composition in relation to climate, understand the potential for degradation in dryland ecosystems, and forecast future changes in plant species assemblages. I employ nearly a century of vegetation monitoring data from three North American deserts to demonstrate an approach to determine plant species responses to climate and critical points over a range of climatic conditions at which plant species shift from increases to decreases in abundance (climate pivot points). I assess these metrics from a site to regional scale and highlight how these indicators of plant performance can be modified by the physical and biotic environment. For example, shrubs were more responsive to drought and high temperatures on shallow soils with limited capacity to store water and fine-textured soils with slow percolation rates, whereas perennial grasses were more responsive to precipitation in sparse shrublands than in relatively dense grasslands and shrublands, where competition for water is likely more intense. The responses and associated climate pivot points of plant species aligned with their lifespan and structural characteristics, and the relationship between responses and climate pivot points provides evidence of the trade-off between the capacity of a plant species to increase in abundance when water is available and its drought resistance.

  11. Optimal irrigation water allocation for a center pivot using remotely sensed data

    Science.gov (United States)

    Hassan Esfahani, L.; McKee, M.

    2013-12-01

    Efficient irrigation can help avoid crop water stress, undesirable leaching of nutrients, and yield reduction due to water shortage, and runoff and soil erosion due to over irrigation. Gains in water use efficiency can be achieved when water application is precisely matched to the spatially distributed crop water demand. This is important to produce high quality crops and otherwise conserve water for greatest efficiency of use. Irrigation efficiency is a term which defines irrigation performance based on indicators such as irrigation uniformity, crop production, economic return and water resources sustainability. The present paper introduces a modeling approach for optimal water allocation to a center pivot irrigation unit in consideration of these types of indicators. Landsat images, weather data and field measurements were used to develop a soil water balance model using Artificial Neural Networks (ANN). The model includes two main modules, one for soil water forecasting and one for optimization of water allocation. The optimization module uses Genetic Algorithms (GA) to identify optimal crop water application rates based on the crop type, growing stage and sensitivity to water stress. The forecasting module allocates water through time across the area covered by the center pivot considering the results from the previous period of irrigation and the operational limitations of the center pivot irrigation system. The model was tested for a farm equipped with a modern sprinkler irrigation system in Scipio, Utah. The solution obtained from the model used up to 30 percent less water without reducing the benefits realized by the irrigator than traditional operating procedures.

  12. Open hardware for open science

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Inspired by the open source software movement, the Open Hardware Repository was created to enable hardware developers to share the results of their R&D activities. The recently published CERN Open Hardware Licence offers the legal framework to support this knowledge and technology exchange.   Two years ago, a group of electronics designers led by Javier Serrano, a CERN engineer, working in experimental physics laboratories created the Open Hardware Repository (OHR). This project was initiated in order to facilitate the exchange of hardware designs across the community in line with the ideals of “open science”. The main objectives include avoiding duplication of effort by sharing results across different teams that might be working on the same need. “For hardware developers, the advantages of open hardware are numerous. For example, it is a great learning tool for technologies some developers would not otherwise master, and it avoids unnecessary work if someone ha...

  13. Open Access

    Science.gov (United States)

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder…

  14. Open Access

    Science.gov (United States)

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder…

  15. Open Source and Open Standards

    NARCIS (Netherlands)

    Koper, Rob

    2006-01-01

    Publication reference: Koper, R. (2008). Open Source and Open Standards. In J. M. Spector, M. Merrill, J. van Merriënboer & M. P. Driscol (Eds.), Handbook of Research on Educational Communications and Technology (3rd ed., pp. 355-368). New York: Routledge.

  16. Kalman Filter-based Single-baseline GNSS Data Processing without Pivot Satellite Changing

    Directory of Open Access Journals (Sweden)

    ZHANG Baocheng

    2015-09-01

    Full Text Available Single-baseline global navigation satellite system (GNSS data are able to be processed into a batch of parameters such as positions, timing information as well as atmospheric delays. The applications of relevance, therefore, consist of relative positioning, time and frequency transfer and so forth. To achieve real-time capability, these parameters are usually estimated by means of Kalman-filter. Moreover, the reliability of these parameters can be further strengthened by forming and then successfully fixing a set of independent double-differenced (DD integer ambiguities. For this purpose, the filter function model is commonly set up based on the DD observation equations (DD filter model. In order to preserve the continuity of the filter, DD filter model needs to explicitly refer to another pivot satellite once the previous one becomes invisible. This thereby implies that, before being predicted to the next epoch, the former filtered DD ambiguity vector has to be “mapped” with respect to the newly-defined pivot satellite. In addition to that, the estimated receiver phase clocks using DD filter model may soak up distinct between-receiver single-differenced (SD ambiguities belonging to different pivot satellites and would thereby be subject to apparent “integer jumps”. In this contribution, SD observation equations involving estimable DD ambiguity parameters are alternatively selected as the filter function model (SD filter model. Our analyses suggest that, both DD and SD filter models are equivalent in theory, but differ from each other as far as their implementations are concerned. Typically, for SD filter model, no effort should be made to map DD ambiguities, thus implying less intensive computational burden and better flexibility than DD filter model. At the same time, receiver phase clocks determined by SD filter model are free from “integer jumps” and thus are particularly beneficial for frequency transfer.

  17. Motion within the unstable cervical spine during patient maneuvering: the neck pivot-shift phenomenon.

    Science.gov (United States)

    Lador, Ran; Ben-Galim, Peleg; Hipp, John A

    2011-01-01

    Cervical extrication collars are applied to millions of blunt trauma victims despite the lack of any evidence that a collar can protect against secondary injuries to the cervical spine. Cadaver studies support that in the presence of a dissociative injury, substantial motion can occur within the occipitocervical spine with collar application or during patient transfers. Little is known about the biomechanics of cervical stabilization; hence, it is difficult to develop and test improved immobilization strategies. Severe unstable injuries were created in seven fresh whole human cadavers. Rigid collars were applied with the body in a neutral position. Computed tomographic examinations were obtained before and after tilting the body or backboard as would be done during patient transport or to inspect the back. Relative displacements between vertebrae at the site of the injury were measured from the Computed tomographic examinations. The overall relative alignment between body and collar was assessed to understand the mechanisms that may facilitate motion at the injury site. Intervertebral motion averaged 7.7 mm±6.8 mm in the axial plain and 2.9 mm±2.5 mm in the cranial-caudal direction. The rigid collars appeared to create pivot points where the collar contacts the head in the region under the ear and where the collar contacts the shoulders. Rigid cervical collars appear to create pivot points that shift the center of rotation lateral to the spine and contribute to the intervertebral motions that were measured. Immobilization strategies that avoid these neck pivot-shift phenomena may help to reduce secondary injuries to the cervical spine. The whole cadaver model with simulation of patient maneuvers may provide an effective test method for cervical immobilization.

  18. Clusters and pivots for evaluating a large numberof alternatives in AHP

    Directory of Open Access Journals (Sweden)

    Alessio Ishizaka

    2012-04-01

    Full Text Available AHP has been successful in many cases but it has a major limitation: a larger number of alternatives requires a high number of judgements in the comparison matrices. In order to reduce this problem,we present a method with clusters and pivots. This method also helps with a further four problems of the Analytic Hierarchy Process. It enlarges the comparison scale, facilitates the construction of a consistent or near consistent matrix, eliminates the problem of the choice of the priorities derivation method and allows the use of incomparable alternatives.

  19. Tropical grasslands: A pivotal place for a more multi-functional agriculture.

    Science.gov (United States)

    Boval, Maryline; Angeon, Valérie; Rudel, Tom

    2017-02-01

    Tropical grasslands represent a pivotal arena for the sustainable intensification of agriculture in the coming decades. The abundant ecosystem services provided by the grasslands, coupled with the aversion to further forest destruction, makes sustainable intensification of tropical grasslands a high policy priority. In this article, we provide an inventory of agricultural initiatives that would contribute to the sustainable intensification of the tropical grassland agro-ecosystem, and we recommend a shift in the scientific priorities of animal scientists that would contribute to realization of a more agro-ecological and multi-functional agriculture in the world's tropical grasslands.

  20. Open IS

    DEFF Research Database (Denmark)

    Germonprez, Matt; Crowston, Kevin; Avital, Michel

    2013-01-01

    The collective intelligence and collective action of “open” communities have produced a variety of complex knowledge goods and radical social change. The Information Systems (IS) community has invested significant effort into researching open communities and the ecosystems in which they operate...... therefore seeks to stimulate a thoughtful and dynamic discussion around the proposition that becoming a more open community will enhance the IS discipline’s scholarly inquiry and global impact....

  1. Open IS

    DEFF Research Database (Denmark)

    Germonprez, Matt; Crowston, Kevin; Avital, Michel

    2013-01-01

    The collective intelligence and collective action of “open” communities have produced a variety of complex knowledge goods and radical social change. The Information Systems (IS) community has invested significant effort into researching open communities and the ecosystems in which they operate...... therefore seeks to stimulate a thoughtful and dynamic discussion around the proposition that becoming a more open community will enhance the IS discipline’s scholarly inquiry and global impact....

  2. Pivotal connection for articulated column of sea-bed working structure. Leddforbindelse for en soeyle for arbeide paa havbunnen

    Energy Technology Data Exchange (ETDEWEB)

    Tuson, S.; Chilardi, J.P.

    1984-08-20

    The invention relates to a pivotal connecting device of the kind forming a universal Cardan joint coupling in particular for a compliant or articulated column of a sea-bed working structure, said column being pivotally connected to a base member, wherein said universal Cardan joint coupling is associated with one or more rigid connecting ducts for conveying the flow of at least one fluid between said base member and said column. 4 drawings.

  3. Resilience Pivots: Stability and Identity in a Social-Ecological-Cultural System

    Directory of Open Access Journals (Sweden)

    Stephanie J. Rotarangi

    2014-03-01

    Full Text Available How is cultural resilience achieved in the face of significant social and ecological change? Is resilience compatible with changed structures, functions, and feedbacks as long as identity is maintained? The concept of cultural resilience has been less explored than its older siblings ecological resilience, social resilience, and social-ecological resilience. We seek to redress the balance, drawing from resilience thinking to examine how a New Zealand Māori tribal group of landowners retained strong cultural identity and connectedness to their land despite enduring significant changes in land use, economy, tenure, and governance. The landowners negotiated radical transformations in the ecology and land use of their home lands on terms that supported matters of cultural importance. The key resilience concepts of adaptation and transformation were helpful in analyzing the trajectory of change, but fell short of representing the elements of stability that supported the cultural resilience of the landowners. The concept of resilience pivots was designed to address this conceptual gap, and to offer another heuristic to resilience thinking by focusing on stability rather than change. Resilience pivots are those elements of a resilient system that remain stable despite adaptation or even transformation of other elements of that system, and in doing so support the maintenance of the system's distinctive identity.

  4. Open access

    CERN Document Server

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder consent, and many authors, musicians, filmmakers, and other creators who depend on royalties are understandably unwilling to give their consent. But for 350 years, scholars have written peer-reviewed journal articles for impact, not for money, and are free to consent to open access without losing revenue. In this concise introduction, Peter Suber tells us what open access is and isn't, how it benefits authors and readers of research, how we pay for it, how it avoids copyright problems, how it has moved from the periphery to the mainstream, and what its future may hold. Distilling a decade of Suber's influential writing and thinking about open access, this is the indispe...

  5. Open Brief

    Directory of Open Access Journals (Sweden)

    Andrew Leach

    2013-11-01

    Full Text Available To commence the thirtieth annual conference of the Society of Architectural Historians, Australia and New Zealand (SAHANZ, held on Australia’s Gold Coast in July 2013, ten delegates were invited with very little warning to take five minutes and one image to offer a provocation on the open matters of architectural history in the present moment. The term “open” was taken as the conference theme—a device used by SAHANZ meetings not so much to define the scope of papers presented as to declare the conference flavour year by year. It was not, therefore, an open conference (anything goes so much as a conference on open issues (where, indeed, to go.  The ten interlocutors were invited after the conference to document their interventions and they are presented here as a record of the preoccupations of a specific moment and institutional geography with all the idiosyncrasies and commonalities it might reveal to a broader audience.

  6. Open Education and the Open Science Economy

    Science.gov (United States)

    Peters, Michael A.

    2009-01-01

    Openness as a complex code word for a variety of digital trends and movements has emerged as an alternative mode of "social production" based on the growing and overlapping complexities of open source, open access, open archiving, open publishing, and open science. This paper argues that the openness movement with its reinforcing structure of…

  7. The Open

    Directory of Open Access Journals (Sweden)

    Saitya Brata Das

    2009-12-01

    Full Text Available In the Open darkness and light, remembrance and oblivion, coming into existence and disappearing in death play their originary co-belonging, or co-figuration. Existence belongs to this opening and is exposed to its coming to presence: it is on the basis of this originary opening, this originary historical which is revealed to this mortal being called ‘man,’ on the basis of this revelation, man founds something like politics and history. There thus comes into existence out of this freedom, out of this “play space”2, this field called ‘polis’3 where there takes place war and festival, where historical revolutions tear apart history, brings ruptures and discontinuities in the very mode of his existence, where man seeks the foundation of his own foundation (which is his metaphysical task , where occurs the dialectics of negativity between man and man, where man puts at stake his own death, his own dissolution, and by the power of his own dissolution stands in relation to the total world that he seeks to dominate. This means that man’s attempts to metaphysically found his own political and historical existence must presuppose a far more originary non-foundation, the differentiating revealing of the open, the ungrounded spacing play, or playing space of natality and mortality.

  8. Open innovation

    DEFF Research Database (Denmark)

    West, Joel; Bogers, Marcel

    2017-01-01

    by small, new, and not-for-profit organizations, as well as the linkage of individual actions and motivations to open innovation. Other opportunities include better measuring the costs, benefits, antecedents, mediators and moderators of the effects of OI on performance, and understanding why and how OI...

  9. Off-design performance loss model for radial turbines with pivoting, variable-area stators

    Science.gov (United States)

    Meitner, P. L.; Glassman, A. J.

    1980-01-01

    An off-design performance loss model was developed for variable stator (pivoted vane), radial turbines through analytical modeling and experimental data analysis. Stator loss is determined by a viscous loss model; stator vane end-clearance leakage effects are determined by a clearance flow model. Rotor loss coefficient were obtained by analyzing the experimental data from a turbine rotor previously tested with six stators having throat areas from 20 to 144 percent of design area and were correlated with stator-to-rotor throat area ratio. An incidence loss model was selected to obtain best agreement with experimental results. Predicted turbine performance is compared with experimental results for the design rotor as well as with results for extended and cutback versions of the rotor. Sample calculations were made to show the effects of stator vane end-clearance leakage.

  10. Impact of Functional Electrical Stimulation of Lower Limbs during Sitting Pivot Transfer Motion for Paraplegic People

    Directory of Open Access Journals (Sweden)

    Jovana Jovic

    2013-01-01

    Full Text Available Individuals with Spinal Cord Injury (SCI, perform Sitting Pivot Transfer (SPT motion around fifteen times a day using upper extremities. It can lead to upper limbs pain and often shoulder complications. In this paper, we investigate the influence of Functional Electrical Stimulation (FES on SPT motion of a paraplegic person. First, we proposed to develop a dynamic optimization method in order to predict SPT motion of an able‐bodied subject. This approach has been validated by comparing the computed SPT trajectories with the ones measured during the experiment with an able‐bodied subject. Then, we used the optimization tool to analyze the influence of FES on the SPT maneuver of paraplegic persons. Our results suggest that FES can decrease arm participation during the transfer motion of a paraplegic person.

  11. Frequency domain wave equation forward modeling using gaussian elimination with static pivoting

    Science.gov (United States)

    Jian-Yong, Song; Xiao-Dong, Zheng; Yan, Zhang; Ji-Xiang, Xu; Zhen, Qin; Xue-Juan, Song

    2011-03-01

    Frequency domain wave equation forward modeling is a problem of solving large scale linear sparse systems which is often subject to the limits of computational efficiency and memory storage. Conventional Gaussian elimination cannot resolve the parallel computation of huge data. Therefore, we use the Gaussian elimination with static pivoting (GESP) method for sparse matrix decomposition and multi-source finite-difference modeling. The GESP method does not only improve the computational efficiency but also benefit the distributed parallel computation of matrix decomposition within a single frequency point. We test the proposed method using the classic Marmousi model. Both the single-frequency wave field and time domain seismic section show that the proposed method improves the simulation accuracy and computational efficiency and saves and makes full use of memory. This method can lay the basis for waveform inversion.

  12. Impact of Functional Electrical Stimulation of Lower Limbs during Sitting Pivot Transfer Motion for Paraplegic People

    Directory of Open Access Journals (Sweden)

    Jovana Jovic

    2013-01-01

    Full Text Available Individuals with Spinal Cord Injury (SCI, perform Sitting Pivot Transfer (SPT motion around fifteen times a day using upper extremities. It can lead to upper limbs pain and often shoulder complications. In this paper, we investigate the influence of Functional Electrical Stimulation (FES on SPT motion of a paraplegic person. First, we proposed to develop a dynamic optimization method in order to predict SPT motion of an able-bodied subject. This approach has been validated by comparing the computed SPT trajectories with the ones measured during the experiment with an able-bodied subject. Then, we used the optimization tool to analyze the influence of FES on the SPT maneuver of paraplegic persons. Our results suggest that FES can decrease arm participation during the transfer motion of a paraplegic person.

  13. Achieving numerical accuracy and high performance using recursive tile LU factorization with partial pivoting

    KAUST Repository

    Dongarra, Jack

    2013-09-18

    The LU factorization is an important numerical algorithm for solving systems of linear equations in science and engineering and is a characteristic of many dense linear algebra computations. For example, it has become the de facto numerical algorithm implemented within the LINPACK benchmark to rank the most powerful supercomputers in the world, collected by the TOP500 website. Multicore processors continue to present challenges to the development of fast and robust numerical software due to the increasing levels of hardware parallelism and widening gap between core and memory speeds. In this context, the difficulty in developing new algorithms for the scientific community resides in the combination of two goals: achieving high performance while maintaining the accuracy of the numerical algorithm. This paper proposes a new approach for computing the LU factorization in parallel on multicore architectures, which not only improves the overall performance but also sustains the numerical quality of the standard LU factorization algorithm with partial pivoting. While the update of the trailing submatrix is computationally intensive and highly parallel, the inherently problematic portion of the LU factorization is the panel factorization due to its memory-bound characteristic as well as the atomicity of selecting the appropriate pivots. Our approach uses a parallel fine-grained recursive formulation of the panel factorization step and implements the update of the trailing submatrix with the tile algorithm. Based on conflict-free partitioning of the data and lockless synchronization mechanisms, our implementation lets the overall computation flow naturally without contention. The dynamic runtime system called QUARK is then able to schedule tasks with heterogeneous granularities and to transparently introduce algorithmic lookahead. The performance results of our implementation are competitive compared to the currently available software packages and libraries. For example

  14. Pivotal response treatment for preschoolers with autism spectrum disorder: Defining a predictor profile.

    Science.gov (United States)

    Fossum, Kristin-Lee; Williams, Loriann; Garon, Nancy; Bryson, Susan E; Smith, Isabel M

    2017-08-31

    Behavioral characteristics of children with autism spectrum disorder (ASD) who respond positively to Pivotal Response Treatment (PRT) have been described previously, based on single-subject design research. The present study examined several such characteristics, as well as positive affect, as predictors of expressive language (EL) gains in a representative sample of preschoolers with ASD (n = 57) enrolled in a PRT-based community early intervention program. Children's cognitive ability, positive affect, and levels of appropriate toy contact measured at the start of intervention each contributed significantly to the prediction of EL outcomes. Together these variables accounted for 40% of the total outcome variance. In addition, a profile of increased EL ability, positive affect and appropriate toy contact, and decreased social avoidance and stereotyped and repetitive vocalizations was associated with greater gains during intervention. Results are discussed in relation to their implications for understanding both the variable treatment response documented in children with ASD and how to tailor treatment to optimize individual benefit. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. The study examined behavior of 57 preschoolers who made the greatest and least gains from 1 year of a community Pivotal Response Treatment program. Using pre-treatment videos, we saw that children who made the most progress showed more language, positive affect, and appropriate interactions with toys, also less avoidance of people and fewer repetitive vocalizations. Behavior profiles can be used to match treatment to individual children's needs. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

  15. Open Source, Open Access, Open Review, Open Data. Initiativen zu mehr Offenheit in der digitalen Welt

    OpenAIRE

    Herb, Ulrich

    2011-01-01

    The article discusses the principles of openess, open access and open availability of information based on the examples of open access to scientific information, open government data, open geographical data and open source software.

  16. Open Source, Open Access, Open Review, Open Data. Initiativen zu mehr Offenheit in der digitalen Welt

    OpenAIRE

    Herb, Ulrich

    2011-01-01

    The article discusses the principles of openess, open access and open availability of information based on the examples of open access to scientific information, open government data, open geographical data and open source software.

  17. OpenAPC. Open-Access-Publikationskosten als Open Data

    OpenAIRE

    Tullney, Marco

    2015-01-01

    Präsentationsfolien zum Vortrag „OpenAPC. Open-Access-Publikationskosten als Open Data“ in der Session „Ausgestaltung eines wissenschaftsadäquaten APC-Marktes: Grundsätze, Finanzierungsansätze und Management“ der Open-Access-Tage 2015 in Zürich (https://www.open-access.net/community/open-access-tage/open-access-tage-2015-zuerich/programm/#c1974)

  18. A Multicenter Pivotal Study to Evaluate Tissue Stabilized-Guided Subcision Using the Cellfina Device for the Treatment of Cellulite With 3-Year Follow-up.

    Science.gov (United States)

    Kaminer, Michael S; Coleman, William P; Weiss, Robert A; Robinson, Deanne M; Grossman, Jody

    2017-06-28

    Cellulite is a common female cosmetic concern for which no single treatment option had been proven effective over the long term. A novel tissue stabilized-guided subsicion system (TS-GS system) has demonstrated significant reduction in the appearance of cellulite after treatment. The objective of this extended follow-up period was to assess the effectiveness of TS-GS out to 3 years after initial treatment. After completing an open-label, multicenter, pivotal study, 45 subjects were followed for an extended period of up to 3 years after receiving a single treatment using the TS-GS system. Treatment areas were photographed prior to the procedure and at multiple time points post-treatment throughout the 3 years. In this open-label study, subjects served as their own controls. Effectiveness was assessed based on blinded independent physician panel assessments of improvement from baseline using a cellulite severity scale. Subject aesthetic improvement and patient-reported satisfaction were also collected. The results of this trial supported Food and Drug Administration clearance of the device for the long-term reduction in the appearance of cellulite following TS-GS. These data further demonstrate the safety and efficacy of this treatment with no reduction in treatment benefits out to 3 years.

  19. On the Controllability and Observability of Actively Lubricated Journal Bearings with Pads Featuring Different Nozzle-Pivot Configurations

    DEFF Research Database (Denmark)

    Salazar, Jorge Andrés González; Santos, Ilmar

    2017-01-01

    and/or actively high pressurized oil into the rotor-pad gap through, commonly, a single radial nozzle. For the work goal, a four degrees-of-freedom (DOFs) ALB system linking the mechanical with the hydraulic dynamics is presented and studied, comprising: (i) the vertical journal movement, (ii) the pad...... tilt angle, (iii) the vertical pad movement-due to the pivot flexibility, and (iv) the controllable force as the hydraulic DOF. The test rig consists of a rigid rotor supported by a single rocker-pivoted rigid pad. A thorough parametric study is carried out by investigating the effects of: (a) nozzle...

  20. Open Images

    DEFF Research Database (Denmark)

    Sanderhoff, Merete

    2013-01-01

    Museums around the world hold enormous troves of public domain artworks. In digitized form, they can be powerful tools for research and learning, as well as building blocks, in the hands of students, teachers, scholars, developers, and creative people. By opening up their digitized assets for reuse......, museums have a unique opportunity to broaden the scope of their public mission to serve and educate the public on 21st century media terms. What could be controversial about that? Art museums have a long legacy of restricting access to high quality images of artworks in order to protect them from improper...

  1. Open University

    CERN Document Server

    Pentz,M

    1975-01-01

    Michel Pentz est née en Afrique du Sud et venu au Cern en 1957 comme physicien et président de l'associaion du personnel. Il est également fondateur du mouvement Antiapartheid de Genève et a participé à la fondation de l'Open University en Grande-Bretagne. Il nous parle des contextes pédagogiques, culturels et nationaux dans lesquels la méthode peut s'appliquer.

  2. Pivot method for global optimization: A study of structures and phase changes in water clusters

    Science.gov (United States)

    Nigra, Pablo Fernando

    In this thesis, we have carried out a study of water clusters. The research work has been developed in two stages. In the first stage, we have investigated the properties of water clusters at zero temperature by means of global optimization. The clusters were modeled by using two well known pairwise potentials having distinct characteristics. One is the Matsuoka-Clementi-Yoshimine potential (MCY) that is an ab initio fitted function based on a rigid-molecule model, the other is the Sillinger-Rahman potential (SR) which is an empirical function based on a flexible-molecule model. The algorithm used for the global optimization of the clusters was the pivot method, which was developed in our group. The results have shown that, under certain conditions, the pivot method may yield optimized structures which are related to one another in such a way that they seem to form structural families. The structures in a family can be thought of as formed from the aggregation of single units. The particular types of structures we have found are quasi-one dimensional tubes built from stacking cyclic units such as tetramers, pentamers, and hexamers. The binding energies of these tubes form sequences that span smooth curves with clear asymptotic behavior; therefore, we have also studied the sequences applying the Bulirsch-Stoer (BST) algorithm to accelerate convergence. In the second stage of the research work, we have studied the thermodynamic properties of a typical water cluster at finite temperatures. The selected cluster was the water octamer which exhibits a definite solid-liquid phase change. The water octamer also has several low lying energy cubic structures with large energetic barriers that cause ergodicity breaking in regular Monte Carlo simulations. For that reason we have simulated the octamer using paralell tempering Monte Carlo combined with the multihistogram method. This has permited us to calculate the heat capacity from very low temperatures up to T = 230 K. We

  3. Small ruminant macrophage polarization may play a pivotal role on lentiviral infection.

    Science.gov (United States)

    Crespo, Helena; Bertolotti, Luigi; Juganaru, Magda; Glaria, Idoia; de Andrés, Damián; Amorena, Beatriz; Rosati, Sergio; Reina, Ramsés

    2013-09-26

    Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal role on the host's innate and adaptative immune responses against parasites by becoming differentially activated. Macrophage heterogeneity can tentatively be classified into classically differentiated macrophages (M1) through stimulation with IFN-γ displaying an inflammatory profile, or can be alternatively differentiated by stimulation with IL-4/IL-13 into M2 macrophages with homeostatic functions. Since infection by SRLV can modulate macrophage functions we explored here whether ovine and caprine macrophages can be segregated into M1 and M2 populations and whether this differential polarization represents differential susceptibility to SRLV infection. We found that like in human and mouse systems, ovine and caprine macrophages can be differentiated with particular stimuli into M1/M2 subpopulations displaying specific markers. In addition, small ruminant macrophages are plastic since M1 differentiated macrophages can express M2 markers when the stimulus changes from IFN-γ to IL-4. SRLV replication was restricted in M1 macrophages and increased in M2 differentiated macrophages respectively according to viral production. Identification of the infection pathways in macrophage populations may provide new targets for eliciting appropriate immune responses against SRLV infection.

  4. Dichromatic state sum models for four-manifolds from pivotal functors

    CERN Document Server

    Bärenz, Manuel

    2016-01-01

    A family of invariants of smooth, oriented four-dimensional manifolds is defined via handle decompositions and Kirby calculus. It is shown that some of them are stronger than the signature and Euler invariant. The invariants are parameterised by a pivotal functor from a spherical fusion category into a ribbon fusion category. A state sum formula for the invariant is constructed via a chain mail procedure, so a large class of topological state sum models can be phrased in terms of it. Most prominently, the Crane-Yetter state sum over an arbitrary ribbon fusion category is recovered, including the nonmodular case. Another example is the four-dimensional Dijkgraaf-Witten model. Derivations of state space dimensions of some TQFTs as special cases agree with recent calculations of ground state degeneracies in Walker-Wang models. It is also shown that the Crane-Yetter invariant for nonmodular categories is stronger than signature and Euler invariant. Relations to different approaches to quantum gravity such as Cart...

  5. Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis.

    Science.gov (United States)

    Rizzoti, Karine; Lovell-Badge, Robin

    2017-04-15

    Along with the sub-ventricular zone of the forebrain lateral ventricles and the sub-granular zone of the dentate gyrus in the hippocampus, the hypothalamus has recently emerged as a third gliogenic and neurogenic niche in the central nervous system. The hypothalamus is the main regulator of body homeostasis because it centralizes peripheral information to regulate crucial physiological functions through the pituitary gland and the autonomic nervous system. Its ability to sense signals originating outside the brain relies on its exposure to blood-born molecules through the median eminence, which is localized outside the blood brain barrier. Within the hypothalamus, a population of specialized radial glial cells, the tanycytes, control exposure to blood-born signals by acting both as sensors and regulators of the hypothalamic input and output. In addition, lineage-tracing experiments have recently revealed that tanycytes represent a population of hypothalamic stem cells, defining them as a pivotal cell type within the hypothalamus. Hypothalamic neurogenesis has moreover been shown to have an important role in feeding control and energy metabolism, which challenges previous knowledge and offers new therapeutic options.

  6. Tlx3 Function in the Dorsal Root Ganglion is Pivotal to Itch and Pain Sensations

    Directory of Open Access Journals (Sweden)

    Chengcheng Huang

    2017-06-01

    Full Text Available Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Here, our RNAseq and in situ hybridization data show that the transcription factor Tlx3 is required for the expression of a majority of itch-related molecules in the dorsal root ganglion (DRG. As a result, Tlx3F/F;Nav1.8-cre mice exhibit significantly attenuated acute and dry skin-induced chronic itch. Furthermore, our study indicates that TRPV1 plays a pivotal role in the chronic itch evoked by dry skin and allergic contact dermatitis (ACD. The mutants also display impaired response to cold and inflammatory pain and elevated response to capsaicin, whereas the responses to acute mechanical, thermal stimuli and neuropathic pain remain normal. In Tlx3F/F;Nav1.8-cre mice, TRPV1 is derepressed and expands predominantly into IB4+ non-peptidergic (NP neurons. Collectively, our data reveal a molecular mechanism in regulating the development of pruriceptors and controlling itch and pain sensations.

  7. Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors.

    Science.gov (United States)

    Mattarollo, Stephen R; Loi, Sherene; Duret, Helene; Ma, Yuting; Zitvogel, Laurence; Smyth, Mark J

    2011-07-15

    We show, in a series of established experimental breast adenocarcinomas and fibrosarcomas induced by carcinogen de novo in mice, that the therapeutic efficacy of doxorubicin treatment is dependent on CD8 T cells and IFN-γ production. Doxorubicin treatment enhances tumor antigen-specific proliferation of CD8 T cells in tumor-draining lymph nodes and promotes tumor infiltration of activated, IFN-γ-producing CD8 T cells. Optimal doxorubicin treatment outcome also requires both interleukin (IL)-1β and IL-17 cytokines, as blockade of IL-1β/IL-1R or IL-17A/IL-17Rα signaling abrogated the therapeutic effect. IL-23p19 had no observed role. The presence of γδ T cells, but not Jα18(+) natural killer T cells, at the time of doxorubicin treatment was also important. In tumor samples taken from breast cancer patients prior to treatment with anthracycline chemotherapy, a correlation between CD8α, CD8β, and IFN-γ gene expression levels and clinical response was observed, supporting their role in the therapeutic efficacy of anthracyclines in humans. Overall, these data strongly support the pivotal contribution of both innate and adaptive immunity in treatment outcomes of anthracycline chemotherapy. ©2011 AACR.

  8. Effect of pivot location and passive heave on propulsion from a pitching airfoil

    Science.gov (United States)

    Mackowski, A. W.; Williamson, C. H. K.

    2017-01-01

    We experimentally investigate the propulsive characteristics of a pitching NACA 0012 airfoil section, with emphasis on thrust and propulsive efficiency, at a Reynolds number of 1.7 ×104 . For the sake of mechanical simplicity, we consider an airfoil restricted to a single actuator in the pitching direction. We examine the effect of changing the airfoil's axis of rotation, finding that contrary to Garrick's linear theory, there exists a pitching axis near the airfoil that maximizes propulsive efficiency. Next, we examine the effect of placing passive springs on the airfoil in the heave (transverse) direction using our Cyber-Physical Fluid Dynamics technique. This elastic heaving motion allows the airfoil to combine pitching and heaving modes while being actuated only in the pitching direction. Two sets of dynamics are considered: one case where the airfoil is weighted unevenly and pitched about its center of mass (so that the resulting heaving motion is independent of inertial forces), and another case where the airfoil's center of mass is fixed at its centroid. For pitching at an amplitude of 8∘ and a reduced frequency k of two, we find that elastic heave produces a maximum propulsive efficiency of 35%, compared to 25% without any heave motion. Further, while operating at the same efficiency as the static-pivot case, we find that passive heaving greatly increases the magnitude of the airfoil's thrust. The airfoil configurations with highest propulsive efficiency generally involve pitching near or ahead of the airfoil's leading edge.

  9. Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.

    Science.gov (United States)

    Alaimo, Alessandro; Alberdi, Araitz; Gomis-Perez, Carolina; Fernández-Orth, Juncal; Bernardo-Seisdedos, Ganeko; Malo, Covadonga; Millet, Oscar; Areso, Pilar; Villarroel, Alvaro

    2014-01-01

    Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, helices A and B, and it is required for exit from the endoplasmic reticulum. However, the molecular mechanisms by which CaM controls channel trafficking are currently unknown. Here we used two complementary approaches to explore the molecular events underlying the association between CaM and Kv7.2 and their regulation by Ca(2+). First, we performed a fluorometric assay using dansylated calmodulin (D-CaM) to characterize the interaction of its individual lobes to the Kv7.2 CaM binding site (Q2AB). Second, we explored the association of Q2AB with CaM by NMR spectroscopy, using (15)N-labeled CaM as a reporter. The combined data highlight the interdependency of the N- and C-lobes of CaM in the interaction with Q2AB, suggesting that when CaM binds Ca(2+) the binding interface pivots between the N-lobe whose interactions are dominated by helix B and the C-lobe where the predominant interaction is with helix A. In addition, Ca(2+) makes CaM binding to Q2AB more difficult and, reciprocally, the channel weakens the association of CaM with Ca(2+).

  10. Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.

    Directory of Open Access Journals (Sweden)

    Alessandro Alaimo

    Full Text Available Kv7.2 (KCNQ2 is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM binds to two intracellular C-terminal segments of Kv7.2 channels, helices A and B, and it is required for exit from the endoplasmic reticulum. However, the molecular mechanisms by which CaM controls channel trafficking are currently unknown. Here we used two complementary approaches to explore the molecular events underlying the association between CaM and Kv7.2 and their regulation by Ca(2+. First, we performed a fluorometric assay using dansylated calmodulin (D-CaM to characterize the interaction of its individual lobes to the Kv7.2 CaM binding site (Q2AB. Second, we explored the association of Q2AB with CaM by NMR spectroscopy, using (15N-labeled CaM as a reporter. The combined data highlight the interdependency of the N- and C-lobes of CaM in the interaction with Q2AB, suggesting that when CaM binds Ca(2+ the binding interface pivots between the N-lobe whose interactions are dominated by helix B and the C-lobe where the predominant interaction is with helix A. In addition, Ca(2+ makes CaM binding to Q2AB more difficult and, reciprocally, the channel weakens the association of CaM with Ca(2+.

  11. Minimal clinically important difference in Parkinson's disease as assessed in pivotal trials of pramipexole extended release.

    Science.gov (United States)

    Hauser, Robert A; Gordon, Mark Forrest; Mizuno, Yoshikuni; Poewe, Werner; Barone, Paolo; Schapira, Anthony H; Rascol, Olivier; Debieuvre, Catherine; Fräßdorf, Mandy

    2014-01-01

    Background. The minimal clinically important difference (MCID) is the smallest change in an outcome measure that is meaningful for patients. Objectives. To calculate the MCID for Unified Parkinson's Disease Rating Scale (UPDRS) scores in early Parkinson's disease (EPD) and for UPDRS scores and "OFF" time in advanced Parkinson's disease (APD). Methods. We analyzed data from two pivotal, double-blind, parallel-group trials of pramipexole ER that included pramipexole immediate release (IR) as an active comparator. We calculated MCID as the mean change in subjects who received active treatment and rated themselves "a little better" on patient global impression of improvement (PGI-I) minus the mean change in subjects who received placebo and rated themselves unchanged. Results. MCIDs in EPD (pramipexole ER, pramipexole IR) for UPDRS II were -1.8 and -2.0, for UPDRS III -6.2 and -6.1, and for UPDRS II + III -8.0 and -8.1. MCIDs in APD for UPDRS II were -1.8 and -2.3, for UPDRS III -5.2 and -6.5, and for UPDRS II + III -7.1 and -8.8. MCID for "OFF" time (pramipexole ER, pramipexole IR) was -1.0 and -1.3 hours. Conclusions. A range of MCIDs is emerging in the PD literature that provides the basis for power calculations and interpretation of clinical trials.

  12. Square-Root Lasso: Pivotal Recovery of Sparse Signals via Conic Programming

    CERN Document Server

    Belloni, Alexandre; Wang, Lie

    2010-01-01

    We propose a pivotal method for estimating high-dimensional sparse linear regression models, where the overall number of regressors $p$ is large, possibly much larger than $n$, but only $s$ regressors are significant. The method is a modification of LASSO, called square-root LASSO. The method neither relies on the knowledge of the standard deviation $\\sigma$ of the regression errors nor does it need to pre-estimate $\\sigma$. Despite not knowing $\\sigma$, square-root LASSO achieves near-oracle performance, attaining the convergence rate $\\sigma \\sqrt{(s/n)\\log p}$, and thus matching the performance of the standard LASSO that knows $\\sigma$. Moreover, we show that these results are valid for both Gaussian and non-Gaussian errors, under some mild moment restrictions, using moderate deviation theory. Finally, we formulate the square-root LASSO as a solution to a convex conic programming problem, which allows us to use efficient computational methods, such as interior point methods, to implement the estimator.

  13. A long term clinical outcome of the Medial Pivot Knee Arthroplasty System.

    Science.gov (United States)

    Macheras, George A; Galanakos, Spyridon P; Lepetsos, Panagiotis; Anastasopoulos, Panagiotis P; Papadakis, Stamatios A

    2017-03-01

    The ideal total knee arthroplasty (TKA) should provide maximum range of motion and functional stability for all desired daily activities and, if possible, to replicate normal knee kinematics and function. The ADVANCE® Medial Pivot (AMP) Knee System was designed with a highly congruent medial compartment and a less conforming lateral compartment to more closely mimic the kinematics of the normal knee and to offer more stability through out of range of motion (ROM). The purpose of this study was to evaluate the long-term clinical and radiographic outcomes of this TKA system. Three hundred and twenty-five (325) patients (347 knees) with knee osteoarthritis underwent a TKA using the AMP prosthesis in our Department. For evaluation, objective and subjective clinical rating systems along with radiograph series were used. The average follow-up was 15.2years. All patients showed a statistically significant improvement (p<0.0005) in the Knee Society clinical rating system, Western Ontario and McMaster Universities Osteoarthritis Index questionnaire, SF-12® questionnaire, and Oxford knee score. The majority of patients (94%) were able to perform age-appropriate activities with a mean knee flexion of 120° (range, 105°-135°) at final follow-up. Survival analysis showed a cumulative success rate of 98.8% at 17years. The obtained results demonstrate excellent long-term clinical outcome for this knee design. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  14. "Anatomic" single-bundle anterior cruciate ligament reconstruction reduces both anterior translation and internal rotation during the pivot shift.

    Science.gov (United States)

    Porter, Mark D; Shadbolt, Bruce

    2014-12-01

    The ability of single-bundle anterior cruciate ligament (ACL) reconstruction to restore rotational control has been questioned by proponents of the double-bundle technique. The term anatomic positioning has become popularized in recognition of the incorrect positioning sometimes used in the past, which may have contributed to the lack of rotation control. The pivot-shift test remains the most clinically useful measure of ACL deficiency, and it is now possible to measure it both accurately and objectively using computer navigation. Single-bundle ACL reconstruction will reduce anterior translation and internal rotation of the tibia during the pivot-shift test when compared with the contralateral uninjured knee. Descriptive laboratory study. A total of 20 patients with an acute isolated ACL rupture underwent reconstruction with a single-bundle autologous hamstring graft. Computer navigation was used intraoperatively to plot the pivot shift before and after reconstruction. The opposite uninjured knee was used as a control. Statistical analysis was used to compare the pivot shifts before and after surgery. Single-bundle ACL reconstruction produced a significant reduction in anterior translation, from a mean ± SD of 17.4 ± 3.80 mm to 6.4 ± 1.95 mm (P operated knee both before and after surgery. It is possible to reduce both anterior translation and internal rotation, which occur during the pivot-shift test in the ACL-deficient knee, using single-bundle ACL reconstruction, when measured at the time of surgery. However, normal motion is not fully restored. © 2014 The Author(s).

  15. OpenER, a Dutch Initiative in Open Educational Resources

    Science.gov (United States)

    Schuwer, Robert; Mulder, Fred

    2009-01-01

    Over the period 2006-2008, the Dutch Open Universiteit Nederland conducted an experiment in which Open Educational Resources (OER) were offered in an effort to bridge the gap between informal and formal learning and to establish a new style of entry portal to higher education with no barriers at all. OpenER received considerable attention both in…

  16. The glial scar-monocyte interplay: a pivotal resolution phase in spinal cord repair.

    Directory of Open Access Journals (Sweden)

    Ravid Shechter

    Full Text Available The inflammatory response in the injured spinal cord, an immune privileged site, has been mainly associated with the poor prognosis. However, recent data demonstrated that, in fact, some leukocytes, namely monocytes, are pivotal for repair due to their alternative anti-inflammatory phenotype. Given the pro-inflammatory milieu within the traumatized spinal cord, known to skew monocytes towards a classical phenotype, a pertinent question is how parenchymal-invading monocytes acquire resolving properties essential for healing, under such unfavorable conditions. In light of the spatial association between resolving (interleukin (IL-10 producing monocytes and the glial scar matrix chondroitin sulfate proteoglycan (CSPG, in this study we examined the mutual relationship between these two components. By inhibiting the de novo production of CSPG following spinal cord injury, we demonstrated that this extracellular matrix, mainly known for its ability to inhibit axonal growth, serves as a critical template skewing the entering monocytes towards the resolving phenotype. In vitro cell culture studies demonstrated that this matrix alone is sufficient to induce such monocyte polarization. Reciprocal conditional ablation of the monocyte-derived macrophages concentrated at the lesion margins, using diphtheria toxin, revealed that these cells have scar matrix-resolving properties. Replenishment of monocytic cell populations to the ablated mice demonstrated that this extracellular remodeling ability of the infiltrating monocytes requires their expression of the matrix-degrading enzyme, matrix metalloproteinase 13 (MMP-13, a property that was found here to be crucial for functional recovery. Altogether, this study demonstrates that the glial scar-matrix, a known obstacle to regeneration, is a critical component skewing the encountering monocytes towards a resolving phenotype. In an apparent feedback loop, monocytes were found to regulate scar resolution. This

  17. The pivotal role of semantic memory in remembering the past and imagining the future

    Directory of Open Access Journals (Sweden)

    Muireann eIrish

    2013-04-01

    Full Text Available Episodic memory refers to a complex and multifaceted process which enables the retrieval of richly detailed evocative memories from the past. In contrast, semantic memory is conceptualised as the retrieval of general conceptual knowledge divested of a specific spatiotemporal context. The neural substrates of the episodic and semantic memory systems have been dissociated in healthy individuals during functional imaging studies, and in clinical cohorts, leading to the prevailing view that episodic and semantic memory represent functionally distinct systems subtended by discrete neurobiological substrates. Importantly, however, converging evidence focusing on widespread neural networks now points to significant overlap between those regions essential for retrieval of autobiographical memories, episodic learning, and semantic processing. Here we review recent advances in episodic memory research focusing on neurodegenerative populations which has proved revelatory for our understanding of the complex interplay between episodic and semantic memory. Whereas episodic memory research has traditionally focused on retrieval of autobiographical events from the past, we also include evidence from the recent paradigm shift in which episodic memory is viewed as an adaptive and constructive process which facilitates the imagining of possible events in the future. We examine the available evidence which converges to highlight the pivotal role of semantic memory in providing schemas and meaning whether one is engaged in autobiographical retrieval for the past, or indeed, is endeavouring to construct a plausible scenario of an event in the future. It therefore seems plausible to contend that semantic processing may underlie most, if not all, forms of episodic memory, irrespective of temporal condition.

  18. COSTRUIRE TESTI, STRUTTURARE CONVERSAZIONI: LA DIDATTICA DEI SEGNALI DISCORSIVI COME ELEMENTI PIVOT DELL'INTERAZIONE VERBALE

    Directory of Open Access Journals (Sweden)

    Paloma Pernas

    2011-07-01

    Full Text Available Questo articolo intende analizzare un aspetto importante ma spesso trascurato della didattica dell’italiano come L2/LS: i segnali discorsivi (SD nell’interazione orale spontanea. La prima parte dell’articolo riporta i risultati di uno studio sull’acquisizione dei segnali discorsivi da parte di apprendenti ispanofoni in contesto formale. Questi dati, raccolti nell’ambito di una ricerca corpus-based, sono risultati utili per migliorare la didattica di questi importanti meccanismi dell’interazione orale. La seconda parte dell’articolo passa in rassegna i manuali di italiano più usati nelle scuole spagnole che insegnano lingue straniere agli adulti, con particolare riferimento alla dimensione testuale e ai SD in particolare. Come risultato di questa rassegna critica, si propone una selezione delle attività didattiche maggiormente coerenti, da un lato, con un effettivo approccio comunicativo e, dall’altro, con i nostri risultati acquisizionali.     Constructing texts, structuring conversations: didactics of discourse markers as pivotal elements in verbal interaction   This paper aims to shed light on an important yet neglected aspect of Italian in L2/FL teaching: discourse markers in oral interaction. The first part reports the outcomes of Italian DM acquisition by Spanish learners in formal contexts, gathered  from corpus-based research, which can be useful for improving Italian DM teaching and learning. The second part is a review of the most commonly used Italian textbooks in Spanish language schools for adult learners, focusing on the oral textual dimension and specially DM. The result of this review is a selection of the DM learning activities most suited to a communicative approach and our acquisitional findings.

  19. Openness initiative

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, S.S. [Los Alamos National Lab., NM (United States)

    1995-12-31

    Although antinuclear campaigns seem to be effective, public communication and education efforts on low-level radioactive waste have mixed results. Attempts at public information programs on low-level radioactive waste still focus on influencing public opinion. A question then is: {open_quotes}Is it preferable to have a program focus on public education that will empower individuals to make informed decisions rather than trying to influence them in their decisions?{close_quotes} To address this question, a case study with both quantitative and qualitative data will be used. The Ohio Low-Level Radioactive Waste Education Program has a goal to provide people with information they want/need to make their own decisions. The program initiated its efforts by conducting a statewide survey to determine information needed by people and where they turned for that information. This presentation reports data from the survey and then explores the program development process in which programs were designed and presented using the information. Pre and post data from the programs reveal attitude and knowledge shifts.

  20. Landpower in Asia -- Historical Insights for the Pivot to the Pacific

    Science.gov (United States)

    2013-05-23

    Www.nytimes.com, November 21, 2011, http://www.nytimes.com/2011/11/22/us/politics/ death -of-deficit-deal-opens-up-new-campaign- of-blame.html?_r=1&ref...in the Pacific increased, the dueling “Twin Drives” strategy allowed both a Navy- dominated Central Pacific offensive and an Army-led Southwest...www.nytimes.com/2011/11/22/us/politics/ death -of-deficit-deal-opens-up-new- campaign-of-blame.html?_r=1&ref=opinion (accessed October 11, 2012). “Taiwan

  1. Gallbladder removal - open

    Science.gov (United States)

    Cholecystectomy - open; Surgery - gallbladder - open ... a medical instrument called a laparoscope ( laparoscopic cholecystectomy ). Open gallbladder surgery is used when laparoscopic surgery cannot ...

  2. Opening Address

    Science.gov (United States)

    Crovini, L.

    1994-01-01

    Ladies and Gentlemen To quote Mr Jean Terrien: "Physics must be one step ahead of metrology". A long-serving Director of the BIPM, he said these words when visiting the IMGC in 1970 as a member of the scientific board of our Institute. At that time it was still an open question whether the IMGC should start research work on the absolute measurement of silicon lattice spacing. Mr Terrien underlined the revolutionary character of x-ray interferometry and, eventually, he caused the balance needle to lean towards the ... right direction. Mr Terrien correctly foresaw that, like Michelson's interferometer of 1880, x-ray interferometry could have a prominent place in today's science and technology. And while, in the first case, after more than a century we can see instruments based on electromagnetic wave interaction within every one's reach in laboratories and, sometimes, in workshops, in the second case, twenty-five years since the first development of an x-ray interferometer we can witness its role in nanometrology. Today and tomorrow we meet to discuss how to go beyond the sixth decimal place in the value of the Avogadro constant. We are aware that the quest for this achievement requires the cooperation of scientists with complementary capabilities. I am sure that the present workshop is a very good opportunity to present and discuss results and to improve and extend existing cooperation. The new adjustment of fundamental constants envisaged by the CODATA Task Group is redoubling scientists' efforts to produce competitive values of NA. The results of the measurements of the silicon lattice spacing in terms of an optical wavelength, which were available for the 1986 adjustment, combined with the determination of silicon molar volume, demonstrate how such an NA determination produces a consistent set of other constants and opens the way to a possible redefinition of the kilogram. We shall see in these two days how far we have progressed along this road. For us at the

  3. DMPD: Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory mediators. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16978535 Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory media...l) (.csml) Show Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory media...egulation of dendritic cell-derivedinflammatory mediators. Authors Harizi H, Gualde N. Publication Cell Mol

  4. Open life science research, open software and the open century

    Institute of Scientific and Technical Information of China (English)

    Youhua Chen

    2015-01-01

    At the age of knowledge explosion and mass scientific information, I highlighted the importance of conducting open science in life and medical researches through the extensive usage of open software and documents. The proposal of conducting open science is to reduce the limited repeatability of researches in life science. I outlined the essential steps for conducting open life science and the necessary standards for creating, reusing and reproducing open materials. Different Creative Commons licenses were presented and compared of their usage scope and restriction. As a conclusion, I argued that open materials should be widely adopted in doing life and medical researches.

  5. Open life science research, open software and the open century

    National Research Council Canada - National Science Library

    Youhua Chen

    2015-01-01

    At the age of knowledge explosion and mass scientific information, I highlighted the importance of conducting open science in life and medical researches through the extensive usage of open software and documents...

  6. Open Standards, Open Source, and Open Innovation: Harnessing the Benefits of Openness

    Science.gov (United States)

    Committee for Economic Development, 2006

    2006-01-01

    Digitization of information and the Internet have profoundly expanded the capacity for openness. This report details the benefits of openness in three areas--open standards, open-source software, and open innovation--and examines the major issues in the debate over whether openness should be encouraged or not. The report explains each of these…

  7. New design of care: Assessment of an interdisciplinary orthopaedic clinic with a pivot nurse in the province of Quebec.

    Science.gov (United States)

    Poder, Thomas G; Bellemare, Christian; Bédard, Suzanne K; He, Jie; Lemieux, Renald

    2010-01-01

    New designs of care in orthopaedic clinics are needed to cope with the shortage of orthopaedic surgeons and the lengthening of waiting times. To assess the effectiveness of an interdisciplinary orthopaedic clinic with a pivot nurse in the Canadian province of Quebec with regard to accessibility, quality of care, efficacy and efficiency of the clinic, and patient's quality of life. Two strategies were developed: (1) a selected cohort of new patients attending an orthopaedic service from February to September 2008 were entered into a database recording patient details, source of referral, diagnosis, satisfaction, and quality of life (36-Item Short Form Health Survey version 2). In this setting, 2 sets of questionnaires were administered to the patients: the first one during the first visit and the second one, 2 months later. A total of 243 patients from the case control were compared with 89 patients of the case study, where an interdisciplinary orthopaedic clinic with a pivot nurse has been developed; (2) costs per patient were calculated using the staff timesheets provided by the two orthopaedic clinics. The results showed a significant reduction in the waiting-list duration (accessibility) in the case study clinic owing to a strong decrease in the inappropriate consultations with the orthopaedic consultant. The quality of care remained high, and the target surgeries for total hip and knee replacement were reached, despite a strong shortage of orthopaedic doctors. Interdisciplinary orthopaedic clinic with a pivot nurse is a new approach in the province of Quebec and first results are encouraging.

  8. Development of computer tablet software for clinical quantification of lateral knee compartment translation during the pivot shift test.

    Science.gov (United States)

    Muller, Bart; Hofbauer, Marcus; Rahnemai-Azar, Amir Ata; Wolf, Megan; Araki, Daisuke; Hoshino, Yuichi; Araujo, Paulo; Debski, Richard E; Irrgang, James J; Fu, Freddie H; Musahl, Volker

    2016-01-01

    The pivot shift test is a commonly used clinical examination by orthopedic surgeons to evaluate knee function following injury. However, the test can only be graded subjectively by the examiner. Therefore, the purpose of this study is to develop software for a computer tablet to quantify anterior translation of the lateral knee compartment during the pivot shift test. Based on the simple image analysis method, software for a computer tablet was developed with the following primary design constraint - the software should be easy to use in a clinical setting and it should not slow down an outpatient visit. Translation of the lateral compartment of the intact knee was 2.0 ± 0.2 mm and for the anterior cruciate ligament-deficient knee was 8.9 ± 0.9 mm (p software provides reliable, objective, and quantitative data on translation of the lateral knee compartment during the pivot shift test and meets the design constraints posed by the clinical setting.

  9. Johns Hopkins's first professorship in philosophy: a critical pivot point in the history of American psychology.

    Science.gov (United States)

    Green, Christopher D

    2007-01-01

    The first professorship in philosophy at Johns Hopkins University was contested in the early 1880s by two of the most prominent and influential scholars in America: Charles Sanders Peirce and George Sylvester Morris. A third figure also vied for the position, although he was much less well known at the time: Granville Stanley Hall. Through a series of unexpected circumstances, Hall ultimately won the professorship and then used it to leverage an extraordinary career that included his opening the first American research laboratory in psychology, establishing the American Journal of Psychology, becoming president of Clark University, founding the American Psychological Association, and profoundly affecting the character of developmental psychology in America.

  10. Investigation of the crossed flexure pivot and the dynamics of the momentum management system spacecraft control component and the dynamically tuned gyroscope

    Science.gov (United States)

    Cain, Jeffrey Stuart

    1999-11-01

    The Momentum Management System (MMS) is a novel concept which incorporates the rate sensing capabilities of the Dynamically Tuned Gyro (DTG) and the actuation ability of a gimballed momentum wheel. The mechanical components of the MMS and DTG consist of a rotor, gimbal and shaft which are connected using crossed flexure pivots. This document presents a static and vibration analysis of the crossed flexure pivot and a kinematic and dynamic analysis of the Dynamically Tuned Gyroscope and the Momentum Management System. Hamilton's principle of minimum energy is used to develop static and vibrational models of the crossed flexure pivot. These models were used to design the pivots used in the MMS. Comparisons are made between the static model results and those found in the literature. A discussion of the effects of large angle deflections and wide pivot strips is also included. In order to provide additional experimental validation of the static equations, a pivot was designed and tested and the results compared to the theoretical model. The static model showed that the torsional stiffness of the crossed flexure pivot is dependent on the applied loads and that the buckling load is lower than previously thought. The vibration analysis was used to find the unforced, fundamental frequencies of the crossed flexure pivots used in the MMS. A two body stability analysis of the DTG and MMS involving the gimbal and rotor was performed using small angle equations. This included a study of the effect of using bearings instead of the crossed flexure pivots. The DTG and MMS were found to be unstable only in extreme cases. The dynamic equations were derived using Lagrange's Equations and Hamilton's Canonical Equations. The dynamic equations are used in a numerical simulation which allows the MMS to be modelled. The results show that the three body analysis involving the rotor, gimbal and shaft is more accurate than the standard two body analysis seen in the literature, especially when

  11. Sandia OpenSHMEM

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-15

    Sandia OpenSHMEM is an implementation of the OpenSHMEM Standard over the Portals 4 Networking API and the OpenFabrics Interface (OFI). Sandia OpenSHMEM is designed to be a low-overhead implementation of the OpenSHMEM standard which takes advantage of the many features of the Portals 4 specification.

  12. Open access, open education resources and open data in Uganda.

    Science.gov (United States)

    Salvo, Ivana Di; Mwoka, Meggie; Kwaga, Teddy; Rukundo, Priscilla Aceng; Ernest, Dennis Ssesanga; Osaheni, Louis Aikoriogie; John, Kasibante; Shafik, Kasirye; de Sousa, Agostinho Moreira

    2015-01-01

    As a follow up to OpenCon 2014, International Federation of Medical Students' Associations (IFMSA) students organized a 3 day workshop Open Access, Open Education Resources and Open Data in Kampala from 15-18 December 2014. One of the aims of the workshop was to engage the Open Access movement in Uganda which encompasses the scientific community, librarians, academia, researchers and students. The IFMSA students held the workshop with the support of: Consortium for Uganda University Libraries (CUUL), The Right to Research Coalition, Electronic Information for Libraries (EIFL), Makerere University, International Health Sciences University (IHSU), Pan African Medical Journal (PAMJ) and the Centre for Health Human Rights and Development (CEHURD). All these organizations are based or have offices in Kampala. The event culminated in a meeting with the Science and Technology Committee of Parliament of Uganda in order to receive the support of the Ugandan Members of Parliament and to make a concrete change for Open Access in the country.

  13. Open heart surgery

    Science.gov (United States)

    Heart surgery - open ... lung machine is used in most cases during open heart surgery. While the surgeon works on the ... with these procedures, the surgeon may have to open the chest to do the surgery.

  14. Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: Stress, intestinal hyperpermeability and inflammation

    Institute of Scientific and Technical Information of China (English)

    Ashkan Farhadi; Jeremy Z Fields; Ali Keshavarzian

    2007-01-01

    Mast cells (MC) are pivotal elements in several physiological and immunological functions of the gastrointestinal (GI) tract. MC translate the stress signals that has been transmitted through brain gut axis into release of proinflammatory mediators that can cause stimulation of nerve endings that could affect afferent nerve terminals and change their perception, affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals, modulate the inflammation. Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis.

  15. Apraxia of lid opening

    Directory of Open Access Journals (Sweden)

    Jebasingh Y

    2006-01-01

    Full Text Available Apraxia of lid opening is a condition where patients do not have ptosis but have difficulty in overcoming levator palpebrae inhibition. We report a patient who presented with difficulty in opening eyelids with out diurnal variation, ptosis or blepharospasm. The diagnosis of Apraxia of lid opening is confirmed by electro physiology. The possibility of apraxia of lid opening should be considered in patients who present with difficulty in opening eyes. Various causes of Apraxia of lid opening are discussed.

  16. Three-dimensional kinematic and kinetic analysis of knee rotational stability in ACL-deficient patients during walking, running and pivoting

    DEFF Research Database (Denmark)

    Bohn, Marie Bagger; Petersen, Annemette Krintel; Nielsen, Dennis Brandborg

    2016-01-01

    and kinetic data were collected from both legs of 44 ACLD patients and 16 healthy controls during walking, running and a pivoting maneuver (descending a staircase and immediately pivoting 90° on the landing leg). Motion data were captured using 8 high-speed cameras and a force-plate. Reflective markers were...... intact knees (ACLI) and a knee healthy control group during walking, running and 90° pivoting. We hypothesized a larger tibial internal rotation, a smaller knee joint external moment and a lower rotational stiffness in the ACLD group compared to the ACLI and the control group. METHODS: Kinematic......: The tibial internal rotation of the ACLD knee was not significantly different from the ACLI knee during all three tasks. During walking and running, the tibial rotation of the control group was significantly different from both legs of the ACL-injured patient. For pivoting, no difference in tibial rotation...

  17. A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB project

    Directory of Open Access Journals (Sweden)

    Merle Corinne SC

    2012-05-01

    Full Text Available Abstract Background There have been no major advances in tuberculosis (TB drug development since the first East African/British Medical Research Council short course chemotherapy trial 35 years ago. Since then, the landscape for conducting TB clinical trials has profoundly changed with the emergence of HIV infection, the spread of resistant TB bacilli strains, recent advances in mycobacteriological capacity, and drug discovery. As a consequence questions have arisen on the most appropriate approach to design and conduct current TB trials. To highlight key issues discussed: Is a superiority, equivalence, or non-inferiority design most appropriate? What should be the primary efficacy outcome? How to consider re-infections in the definition of the outcome? What is the optimal length of patient follow-up? Is blinding appropriate when treatment duration in test arm is shorter? What are the appropriate assumptions for sample size calculation? Methods Various drugs are currently in the development pipeline. We are presenting in this paper the design of the most recently completed phase III TB trial, the OFLOTUB project, which is the pivotal trial of a registration portfolio for a gatifloxacin-containing TB regimen. It is a randomized, open-label, multicenter, controlled trial aiming to evaluate the efficacy and safety of a gatifloxacin-containing 4-month regimen (trial registration: ClinicalTrial.gov database: NCT00216385. Results In the light of the recent scientific and regulatory discussions, we discuss some of the design issues in TB clinical trials and more specifically the reasons that guided our choices, in order to best answer the trial objectives, while at the same time satisfying regulatory authority requirements. Conclusion When shortening TB treatment, we are advocating for a non-inferiority, non-blinded design, with a composite unfavorable endpoint assessed 12 months post treatment completion, and added trial procedures specifically

  18. The effects of pressure and temperature on the energetics and pivotal surface in a monoacylglycerol/water gyroid inverse bicontinuous cubic phase.

    Science.gov (United States)

    Tang, T-Y Dora; Seddon, Annela M; Jeworrek, Christoph; Winter, Roland; Ces, Oscar; Seddon, John M; Templer, Richard H

    2014-05-07

    We have studied the effect of pressure and temperature on the location of the pivotal surface in a lipid inverse bicontinuous gyroid cubic phase (Q(G)(II)), described by the area at the pivotal surface (An), the volume between the pivotal surface and the bilayer midplane (Vn), and the molecular volume of the lipid (V). Small angle X-ray scattering (SAXS) was used to measure the swelling behaviour of the lipid, monolinolein, as a function of pressure and temperature, and the data were fitted to two different geometric models: the parallel interface model (PIM), and the constant mean curvature model (CMCM). The results show that an increase in temperature leads to a shift in the location of the pivotal surface towards the bilayer midplane, whilst an increase in pressure causes the pivotal surface to move towards the interfacial region. In addition, we describe the relevance of An, Vn and V for modeling the energetics of curved mesophases with specific reference to the mean curvature at the pivotal surface and discuss the significance of this parameter for modelling the energetics of curved mesophases.

  19. Effects of two types of sprinklers and height in the irrigation of sugar beet with a centre pivot

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, J. N.; Tarjuelo, J. M.; Juan, J. A. de

    2012-11-01

    The main objective of this paper is to analyse the effects of sprinkler type and height above the ground on soil water uniformity (CUs) and sugar beet yield. Irrigation was performed with a centre pivot operating under field conditions with two types of sprinklers, one with a stationary plate (SPS) and the other with a moving plate (MPS), at two heights (1 and 2.5 m). The average coefficient of uniformity (CU) of water application of individual irrigation events with SPS ranged from 74 to 81%, compared to nearly 90% from MPS. The value of the cumulative coefficient of uniformity for the set of irrigation events (CUa) for all sprinkler-height combinations exceeded 90%, a value similar to that obtained for CUS. Results do not show a clear advantage in the final crop response by using sprinklers with MPS or SPS. However, MPS, and especially those located at 1 m in height with a spacing of 1.5 m, have higher water application uniformity, achieving higher yield and yield indexes, as well as higher water use efficiency. The final yield of sugar beet was more influenced by the amount of soil water available for the crop than the small differences in soil water uniformity obtained with the centre pivot. (Author) 62 refs.

  20. A study on the effectiveness of investment strategy based on the concept of pivot points levels using Matthews criterion

    Directory of Open Access Journals (Sweden)

    Antoni Wiliński

    2013-04-01

    Full Text Available In this work, the possibility of assessing traditional investment strategy based on the pivot points for using with other than the commonly used criterion is examined. The authors attempted to apply the Matthews Correlation Coefficient (further reffered as MCC criterion based on a confusion matrix when assessing the strategy to include more factors than the traditional criteria (such as profit, profit vs. Risk, Sharpe ratio, Calmar ratio and to express these factors by one number. The criterion based on a confusion matrix is, in authors beliefs, unique in this application and gives a fairly valuable estimation of trading strategy. An example of several strategies tested on EURUSD 1h time series in selected intervals in the years 2012-2013 is considered. Among these strategies there is a simple strategy based on the concept of pivot points levels and more complex derivative strategies, based on the vector of optimized values of certain parameters. These strategies are evaluated using both traditional criteria and modification of MCC proposed by the authors.

  1. Development of offset pivot guide%偏摆式纠偏机构的研究与设计

    Institute of Scientific and Technical Information of China (English)

    张杰; 裴全喜

    2015-01-01

    重点介绍了偏摆式纠偏机构中纠偏框架和驱动装置的工作原理及结构设计,利用辊筒支架上3个支点的直线运动实现纠偏框架的摆动,驱动装置采用扭轮摩擦传动方式. 由于采用了特殊的工作原理和方法,使纠偏装置具有了更好的适用性和经济性.%It focus on the working principle and structure design of guiding frame and driving device for the offset pivot guide , using linear motion of three pivots of roller bracket to realize swing of the guiding frame , designs the driving device for adopting twist -roller friction drive .Because of adopting especial working principle and means, the guiding system has more applicability and economy .

  2. TLR4-mediated expression of Mac-1 in monocytes plays a pivotal role in monocyte adhesion to vascular endothelium.

    Science.gov (United States)

    Lee, Seung Jin; Choi, Eun Kyoung; Seo, Kyo Won; Bae, Jin Ung; Park, So Youn; Kim, Chi Dae

    2014-01-01

    Toll-like receptor 4 (TLR4) is known to mediate monocyte adhesion to endothelial cells, however, its role on the expression of monocyte adhesion molecules is unclear. In the present study, we investigated the role of TLR4 on the expression of monocyte adhesion molecules, and determined the functional role of TLR4-induced adhesion molecules on monocyte adhesion to endothelial cells. When THP-1 monocytes were stimulated with Kdo2-Lipid A (KLA), a specific TLR4 agonist, Mac-1 expression was markedly increased in association with an increased adhesion of monocytes to endothelial cells. These were attenuated by anti-Mac-1 antibody, suggesting a functional role of TLR4-induced Mac-1 on monocyte adhesion to endothelial cells. In monocytes treated with MK886, a 5-lipoxygenase (LO) inhibitor, both Mac-1 expression and monocyte adhesion to endothelial cells induced by KLA were markedly attenuated. Moreover, KLA increased the expression of mRNA and protein of 5-LO, suggesting a pivotal role of 5-LO on these processes. In in vivo studies, KLA increased monocyte adhesion to aortic endothelium of wild-type (WT) mice, which was attenuated in WT mice treated with anti-Mac-1 antibody as well as in TLR4-deficient mice. Taken together, TLR4-mediated expression of Mac-1 in monocytes plays a pivotal role on monocyte adhesion to vascular endothelium, leading to increased foam cell formation in the development of atherosclerosis.

  3. Libraries Can Make Open Access Happen Today by Simply Redirecting Subscription Funds: An Update on the SCOAP3 Initiative

    CERN Document Server

    Gentil-Beccot, Anne

    2008-01-01

    This article reviews the SCOAP3 initiative which aims to redirect the subscription funds used for the core journals in High Energy Physics, to make them Open Access. This model re-interprets the role of librarians in the Open Access debate. As they are the pivot of the current system, by keeping the lifeblood of scientific information flowing to their scientists, the authors argue that they are the best placed to make it change and take advantage of it.

  4. Glaucoma, Open-Angle

    Science.gov (United States)

    ... Programs Home > Statistics and Data > Glaucoma, Open-angle Glaucoma, Open-angle Open-angle Glaucoma Defined In open-angle glaucoma, the fluid passes ... 2010 2010 U.S. Age-Specific Prevalence Rates for Glaucoma by Age and Race/Ethnicity The prevalence of ...

  5. JISC Open Access Briefing Paper

    OpenAIRE

    Swan, Alma

    2005-01-01

    What Open Access is. What Open Access is not. How is Open Access provided? Open Access archives or repositories. Open Access journals. Why should authors provide Open Access to their work? Further information and resources

  6. JISC Open Access Briefing Paper

    OpenAIRE

    Swan, Alma

    2005-01-01

    What Open Access is. What Open Access is not. How is Open Access provided? Open Access archives or repositories. Open Access journals. Why should authors provide Open Access to their work? Further information and resources

  7. Resource planning for gas utilities: Using a model to analyze pivotal issues

    Energy Technology Data Exchange (ETDEWEB)

    Busch, J.F.; Comnes, G.A.

    1995-11-01

    With the advent of wellhead price decontrols that began in the late 1970s and the development of open access pipelines in the 1980s and 90s, gas local distribution companies (LDCs) now have increased responsibility for their gas supplies and face an increasingly complex array of supply and capacity choices. Heretofore this responsibility had been share with the interstate pipelines that provide bundled firm gas supplies. Moreover, gas supply an deliverability (capacity) options have multiplied as the pipeline network becomes increasing interconnected and as new storage projects are developed. There is now a fully-functioning financial market for commodity price hedging instruments and, on interstate Pipelines, secondary market (called capacity release) now exists. As a result of these changes in the natural gas industry, interest in resource planning and computer modeling tools for LDCs is increasing. Although in some ways the planning time horizon has become shorter for the gas LDC, the responsibility conferred to the LDC and complexity of the planning problem has increased. We examine current gas resource planning issues in the wake of the Federal Energy Regulatory Commission`s (FERC) Order 636. Our goal is twofold: (1) to illustrate the types of resource planning methods and models used in the industry and (2) to illustrate some of the key tradeoffs among types of resources, reliability, and system costs. To assist us, we utilize a commercially-available dispatch and resource planning model and examine four types of resource planning problems: the evaluation of new storage resources, the evaluation of buyback contracts, the computation of avoided costs, and the optimal tradeoff between reliability and system costs. To make the illustration of methods meaningful yet tractable, we developed a prototype LDC and used it for the majority of our analysis.

  8. Light-Driven Contact Hearing Aid for Broad-Spectrum Amplification: Safety and Effectiveness Pivotal Study.

    Science.gov (United States)

    Gantz, Bruce J; Perkins, Rodney; Murray, Michael; Levy, Suzanne Carr; Puria, Sunil

    2017-03-01

    Demonstrate safety and effectiveness of the light-driven contact hearing aid to support FDA clearance. A single-arm, open-label investigational-device clinical trial. Two private-practice and one hospital-based ENT clinics. Forty-three subjects (86 ears) with mild-to-severe bilateral sensorineural hearing impairment. Bilateral amplification delivered via a light-driven contact hearing aid comprising a Tympanic Lens (Lens) with a customized platform to directly drive the umbo and a behind-the-ear sound processor (Processor) that encodes sound into light pulses to wirelessly deliver signal and power to the Lens. The primary safety endpoint was a determination of "no change" (PTA4 hearing at the 120-day measurement interval. The primary efficacy endpoint was improvement in word recognition using NU-6 at the 30-day measurement interval over the baseline unaided case. Secondary efficacy endpoints included functional gain from 2 to 10 kHz and speech-in-noise improvement over the baseline unaided case using both omnidirectional and directional microphones. The results for the 86 ears in the study determined a mean change of -0.40 dB in PTA4, indicating no change in residual hearing (p Hearing in Noise Test was 0.75 dB (p = 0.028) and 3.14 dB (p < 0.0001) for the omnidirectional and directional microphone modes, respectively. The safety and effectiveness data supported a de novo 510(k) submission that received clearance from the FDA.

  9. Pivotal role of hMT+ in long-range disambiguation of interhemispheric bistable surface motion.

    Science.gov (United States)

    Duarte, João Valente; Costa, Gabriel Nascimento; Martins, Ricardo; Castelo-Branco, Miguel

    2017-10-01

    It remains an open question whether long-range disambiguation of ambiguous surface motion can be achieved in early visual cortex or instead in higher level regions, which concerns object/surface segmentation/integration mechanisms. We used a bistable moving stimulus that can be perceived as a pattern comprehending both visual hemi-fields moving coherently downward or as two widely segregated nonoverlapping component objects (in each visual hemi-field) moving separately inward. This paradigm requires long-range integration across the vertical meridian leading to interhemispheric binding. Our fMRI study (n = 30) revealed a close relation between activity in hMT+ and perceptual switches involving interhemispheric segregation/integration of motion signals, crucially under nonlocal conditions where components do not overlap and belong to distinct hemispheres. Higher signal changes were found in hMT+ in response to spatially segregated component (incoherent) percepts than to pattern (coherent) percepts. This did not occur in early visual cortex, unlike apparent motion, which does not entail surface segmentation. We also identified a role for top-down mechanisms in state transitions. Deconvolution analysis of switch-related changes revealed prefrontal, insula, and cingulate areas, with the right superior parietal lobule (SPL) being particularly involved. We observed that directed influences could emerge either from left or right hMT+ during bistable motion integration/segregation. SPL also exhibited significant directed functional connectivity with hMT+, during perceptual state maintenance (Granger causality analysis). Our results suggest that long-range interhemispheric binding of ambiguous motion representations mainly reflect bottom-up processes from hMT+ during perceptual state maintenance. In contrast, state transitions maybe influenced by high-level regions such as the SPL. Hum Brain Mapp 38:4882-4897, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley

  10. OpenGL Insights

    CERN Document Server

    Cozzi, Patrick

    2012-01-01

    Get Real-World Insight from Experienced Professionals in the OpenGL Community With OpenGL, OpenGL ES, and WebGL, real-time rendering is becoming available everywhere, from AAA games to mobile phones to web pages. Assembling contributions from experienced developers, vendors, researchers, and educators, OpenGL Insights presents real-world techniques for intermediate and advanced OpenGL, OpenGL ES, and WebGL developers. Go Beyond the Basics The book thoroughly covers a range of topics, including OpenGL 4.2 and recent extensions. It explains how to optimize for mobile devices, explores the design

  11. Dimensions of Openness

    DEFF Research Database (Denmark)

    Dalsgaard, Christian; Thestrup, Klaus

    2015-01-01

    as a matter of engaging educational activities in sociocultural practices of a surrounding society. Openness is not only a matter of opening up the existing, but of developing new educational practices that interact with society. The paper outlines three pedagogical dimensions of openness: transparency...... practices. Openness as joint engagement in the world aims at establishing interdependent collaborative relationships between educational institutions and external practices. To achieve these dimensions of openness, educational activities need to change and move beyond the course as the main format...... for openness. With examples from a university case, the paper discusses how alternative pedagogical formats and educational technologies can support the three dimensions of openness....

  12. Open access and open source in chemistry

    Directory of Open Access Journals (Sweden)

    Todd Matthew H

    2007-02-01

    Full Text Available Abstract Scientific data are being generated and shared at ever-increasing rates. Two new mechanisms for doing this have developed: open access publishing and open source research. We discuss both, with recent examples, highlighting the differences between the two, and the strengths of both.

  13. Een boekje open over Open Source ERP

    NARCIS (Netherlands)

    Sneller, A.C.W.(L.)

    2009-01-01

    Er zijn vele ERP-systemen die met behulp van open source worden ontwikkeld. Organisaties die open source ERP willen implementeren staan voor twee strategische keuzes: hoe zit het met de continuïteit en wie gaat het systeem onderhouden?

  14. Open Government and (Linked (Open (Government (Data

    Directory of Open Access Journals (Sweden)

    Christian Philipp Geiger

    2012-12-01

    Full Text Available This article explores the opening and the free usage of stored public sector data, supplied by state. In the age of Open Government and Open Data it’s not enough just to put data online. It should be rather weighed out whether, how and which supplied public sector data can be published. Open Data are defined as stored data which could be made accessible in a public interest without any restrictions for usage and distribution. These Open Data can possibly be statistics, geo data, maps, plans, environmental data and weather data in addition to materials of the parliaments, ministries and authorities. The preparation and the free access to existing data permit varied approaches to the reuse of data, discussed in the article. In addition, impulses can be given for Open Government – the opening of state and administration, to more transparency, participation and collaboration as well as to innovation and business development. The Open Data movement tries to get to the bottom of current publication processes in the public sector which could be formed even more friendly to citizens and enterprises.

  15. Cryopreservation of testicular tissue or testicular cell suspensions: a pivotal step in fertility preservation

    Science.gov (United States)

    Onofre, J.; Baert, Y.; Faes, K.; Goossens, E.

    2016-01-01

    BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or genetic predisposition can occur at any age. Although semen cryopreservation is the first reflex for preserving male fertility, this cannot help out prepubertal boys. Yet, these boys do have spermatogonial stem cells (SSCs) that able to produce sperm at the start of puberty, which allows them to safeguard their fertility through testicular tissue (TT) cryopreservation. SSC transplantation (SSCT), TT grafting and recent advances in in vitro spermatogenesis have opened new possibilities to restore fertility in humans. However, these techniques are still at a research stage and their efficiency depends on the amount of SSCs available for fertility restoration. Therefore, maintaining the number of SSCs is a critical step in human fertility preservation. Standardizing a successful cryopreservation method for TT and testicular cell suspensions (TCSs) is most important before any clinical application of fertility restoration could be successful. OBJECTIVE AND RATIONALE This review gives an overview of existing cryopreservation protocols used in different animal models and humans. Cell recovery, cell viability, tissue integrity and functional assays are taken into account. Additionally, biosafety and current perspectives in male fertility preservation are discussed. SEARCH METHODS An extensive PubMED and MEDline database search was conducted. Relevant studies linked to the topic were identified by the search terms: cryopreservation, male fertility preservation, (immature)testicular tissue, testicular cell suspension, spermatogonial stem cell, gonadotoxicity, radiotherapy and chemotherapy. OUTCOMES The feasibility of fertility restoration techniques using frozen-thawed TT and TCS has been proven in animal models. Efficient protocols for cryopreserving human TT exist and are currently applied in the clinic. For TCSs, the highest post-thaw viability reported after vitrification is 55.6 ± 23

  16. Development of an automated method to detect sitting pivot transfer phases using biomechanical variables: toward a standardized method

    Directory of Open Access Journals (Sweden)

    Desroches Guillaume

    2012-02-01

    Full Text Available Abstract Background Sitting pivot transfer (SPT is one of the most important, but at the same time strenuous at the upper extremity, functional task for spinal cord injured individuals. In order to better teach this task to those individuals and to improve performance, a better biomechanical understanding during the different SPT phases is a prerequisite. However, no consensus has yet been reached on how to depict the different phases of the SPT. The definition of the phases of the SPT, along with the events characterizing these phases, will facilitate the interpretation of biomechanical outcome measures related to the performance of SPTs as well as strengthen the evidence generated across studies. Methods Thirty-five individuals with a spinal cord injury performed two SPTs between seats of similar height using their usual SPT technique. Kinematics and kinetics were recorded using an instrumented transfer assessment system. Based on kinetic and kinematic measurements, a relative threshold-based algorithm was developed to identify four distinct phases: pre-lift, upper arm loading, lift-pivot and post-lift phases. To determine the stability of the algorithm between the two SPTs, Student t-tests for dependent samples were performed on the absolute duration of each phase. Results The mean total duration of the SPT was 2.00 ± 0.49 s. The mean duration of the pre-lift, upper arm loading, lift-pivot and post-lift phases were 0.74 ± 0.29 s, 0.28 ± 0.13 s, 0.72 ± 0.24 s, 0.27 ± 0.14 s whereas their relative contributions represented approximately 35%, 15%, 35% and 15% of the overall SPT cycle, respectively. No significant differences were found between the trials (p = 0.480-0.891. Conclusion The relative threshold-based algorithm used to automatically detect the four distinct phases of the SPT, is rapid, accurate and repeatable. A quantitative and thorough description of the precise phases of the SPT is prerequisite to better interpret biomechanical

  17. Loss model for off-design performance analysis of radial turbines with pivoting-vane, variable-area stators

    Science.gov (United States)

    Meitner, P. L.; Glassman, A. J.

    1980-01-01

    An off-design performance loss model for a radial turbine with pivoting, variable-area stators is developed through a combination of analytical modeling and experimental data analysis. A viscous loss model is used for the variation in stator loss with setting angle, and stator vane end-clearance leakage effects are predicted by a clearance flow model. The variation of rotor loss coefficient with stator setting angle is obtained by means of an analytical matching of experimental data for a rotor that was tested with six stators, having throat areas from 20 to 144% of the design area. An incidence loss model is selected to obtain best agreement with experimental data. The stator vane end-clearance leakage model predicts increasing mass flow and decreasing efficiency as a result of end-clearances, with changes becoming significantly larger with decreasing stator area.

  18. Potential for Photovoltaic Solar Installation in Non-Irrigated Corners of Center Pivot Irrigation Fields in the State of Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, B.

    2011-07-01

    The State of Colorado expressed an interest in assessing the potential for photovoltaic (PV) solar installations on non-irrigated corners of center-pivot irrigation (CPI) fields throughout the state. Using aerial imagery and irrigated land data available from the Colorado Water Conservation Board, an assessment of potentially suitable sites was produced. Productivity estimates were calculated from that assessment. The total area of non-irrigated corners of CPI fields in Colorado was estimated to be 314,674 acres, which could yield 223,418 acres of installed PV panels assuming 71% coverage in triangular plots. The total potential annual electricity production for the state was estimated to be 56,821 gigawatt hours (GWH), with an average of 1.3 GWH per available plot.

  19. The possible pivotal role of the eastward dust transport from Central Asia in the global temperature decrease

    Institute of Scientific and Technical Information of China (English)

    LIU Mingzhe; WEI Wenshou

    2006-01-01

    It is generally considered that the occurrence of glacial-interglacial gyrations can be explained with the Milankovitch theory. However, the solutions of some problems in the theory are currently not derived yet. After researching the eastward dust transport from Central Asia, we have found that there is a positive feedback mechanism between the eastward dust transport and the global temperature decrease. This magnifies the effect of solar radiation change in the high-latitude area of the Northern Hemisphere, and results in the occurrence of the global glacial epoch. The positive feedback mechanism starts with the reduction of solar radiation in the high-latitude area of the Northern Hemisphere. Subsequently, the global temperature decreases and global glacial epoch occurs, in which the pivotal factor is the eastward dust transport from Central Asia.With the theory of the positive feedback mechanism,some problems in the Milankovitch theory can be solved well.

  20. Loss model for off-design performance analysis of radial turbines with pivoting-vane, variable-area stators

    Science.gov (United States)

    Meitner, P. L.; Glassman, A. J.

    1980-01-01

    An off-design performance loss model for a radial turbine with pivoting, variable-area stators is developed through a combination of analytical modeling and experimental data analysis. A viscous loss model is used for the variation in stator loss with setting angle, and stator vane end-clearance leakage effects are predicted by a clearance flow model. The variation of rotor loss coefficient with stator setting angle is obtained by means of an analytical matching of experimental data for a rotor that was tested with six stators, having throat areas from 20 to 144% of the design area. An incidence loss model is selected to obtain best agreement with experimental data. The stator vane end-clearance leakage model predicts increasing mass flow and decreasing efficiency as a result of end-clearances, with changes becoming significantly larger with decreasing stator area.

  1. Comprehensive characterization of a theophylline riboswitch reveals two pivotal features of Shine-Dalgarno influencing activated translation property.

    Science.gov (United States)

    Cui, Wenjing; Cheng, Jintao; Miao, Shengnan; Zhou, Li; Liu, Zhongmei; Guo, Junling; Zhou, Zhemin

    2017-03-01

    Tuneable gene expression controlled by synthetic biological elements is of great importance to biotechnology and synthetic biology. The synthetic riboswitch is a pivotal type of elements that can easily control the heterologous gene expression in diverse bacteria. In this study, the theophylline-dependent synthetic riboswitch and the corresponding variants with varied spacings between Shine-Dalgarno (SD) sequence and start codon were employed to comprehensively characterize the induction and regulation properties through combining a strong promoter aprE in Bacillus subtilis. Amongst the sets of newly constructed expression elements, the expression element with 9-bp spacing exhibited the higher expression level, a superior induction fold performance, and a considerably lower leaky expression than those with longer or shorter spacings. The riboswitch expression element with 9-bp spacing showed an approximately linear dose dependence from 0 to 8 mM of theophylline. Modification of the SD sequence through the insertion of a single A base prior to the native sequence enables the increase of the expression level post induction while decreasing the induction fold as a result of the elevated leaky level. The riboswitch elements with the engineered SD and the optimal 9-bp spacing exhibit an altered dose dependency in which the approximately linear range shifts to 0-4 mM, although it has a similar profile to the induction process. These results not only provide comprehensive data for the induced expression by a theophylline riboswitch combined with a strong native promoter from B. subtilis but also provide the two pivotal features of SD essential to the modular design of other synthetic riboswitches.

  2. Open Payments Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — Open Payments (otherwise known as the Sunshine Act) - Open Payments is a Congressionally-mandated transparency program that increases awareness of financial...

  3. Open Payments Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — Open Payments (otherwise known as the Sunshine Act) - Open Payments is a Congressionally-mandated transparency program that increases awareness of financial...

  4. OpenCities Project

    Data.gov (United States)

    US Agency for International Development — The Open Cities Project aims to catalyze the creation, management and use of open data to produce innovative solutions for urban planning and resilience challenges...

  5. Open Hardware Business Models

    Directory of Open Access Journals (Sweden)

    Edy Ferreira

    2008-04-01

    Full Text Available In the September issue of the Open Source Business Resource, Patrick McNamara, president of the Open Hardware Foundation, gave a comprehensive introduction to the concept of open hardware, including some insights about the potential benefits for both companies and users. In this article, we present the topic from a different perspective, providing a classification of market offers from companies that are making money with open hardware.

  6. Open Source Business Solutions

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2008-01-01

    Full Text Available This analyses the Open source movement. Open source development process and management is seen different from the classical point of view. This focuses on characteristics and software market tendencies for the main Open source initiatives. It also points out the labor market future evolution for the software developers.

  7. OpenFlow cookbook

    CERN Document Server

    Smiler S, Kingston

    2015-01-01

    This book is intended for network protocol developers, SDN controller application developers, and academics who would like to understand and develop their own OpenFlow switch or OpenFlow controller in any programming language. With basic understanding of OpenFlow and its components, you will be able to follow the recipes in this book.

  8. Open Rotor Development

    Science.gov (United States)

    Van Zante, Dale E.; Rizzi, Stephen A.

    2016-01-01

    The ERA project executed a comprehensive test program for Open Rotor aerodynamic and acoustic performance. System studies used the data to estimate the fuel burn savings and acoustic margin for an aircraft system with open rotor propulsion. The acoustic measurements were used to produce an auralization that compares the legacy blades to the current generation of open rotor designs.

  9. Openness as infrastructure

    Directory of Open Access Journals (Sweden)

    Wilbanks John

    2011-10-01

    Full Text Available Abstract The advent of open access to peer reviewed scholarly literature in the biomedical sciences creates the opening to examine scholarship in general, and chemistry in particular, to see where and how novel forms of network technology can accelerate the scientific method. This paper examines broad trends in information access and openness with an eye towards their applications in chemistry.

  10. Implementing OpenShift

    CERN Document Server

    Miller, Adam

    2013-01-01

    A standard tutorial-based approach to using OpenShift and deploying custom or pre-built web applications to the OpenShift Online cloud.This book is for software developers and DevOps alike who are interested in learning how to use the OpenShift Platform-as-a-Service for developing and deploying applications, how the environment works on the back end, and how to deploy their very own open source Platform-as-a-Service based on the upstream OpenShift Origin project.

  11. Deploying OpenStack

    CERN Document Server

    Pepple, Ken

    2011-01-01

    OpenStack was created with the audacious goal of being the ubiquitous software choice for building public and private cloud infrastructures. In just over a year, it's become the most talked-about project in open source. This concise book introduces OpenStack's general design and primary software components in detail, and shows you how to start using it to build cloud infrastructures. If you're a developer, technologist, or system administrator familiar with cloud offerings such as Rackspace Cloud or Amazon Web Services, Deploying OpenStack shows you how to obtain and deploy OpenStack softwar

  12. OpenSubspace

    DEFF Research Database (Denmark)

    Müller, Emmanuel; Assent, Ira; Günnemann, Stephan

    2009-01-01

    Subspace clustering and projected clustering are recent research areas for clustering in high dimensional spaces. As the field is rather young, there is a lack of comparative studies on the advantages and disadvantages of the different algorithms. Part of the underlying problem is the lack...... of available open source implementations that could be used by researchers to understand, compare, and extend subspace and projected clustering algorithms. In this paper, we discuss the requirements for open source evaluation software. We propose OpenSubspace, an open source framework that meets...... these requirements. OpenSubspace integrates state-of-the-art performance measures and visualization techniques to foster research in subspace and projected clustering....

  13. The application of the instantaneous states reduction to the orbital monitoring of pivotal arcs of the Chang’E-1 satellite

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In the Chinese lunar exploration project,the Chang’E-1 (CE-1) satellite was jointly monitored by the United S-band range and Doppler and the VLBI technique. A real-time reduction of the tracking data is realized to deduce the time series of the instantaneous state vectors (ISV) (position and velocity vec-tors) of the CE-1 satellite,and is applied to the orbital monitoring of pivotal arcs. This paper introduces this real-time data reduction method and its application to the orbital monitoring of pivotal arcs of the CE-1 satellite in order to serve as a source of criticism and reference.

  14. Openness, Web 2.0 Technology, and Open Science

    Science.gov (United States)

    Peters, Michael A.

    2010-01-01

    Open science is a term that is being used in the literature to designate a form of science based on open source models or that utilizes principles of open access, open archiving and open publishing to promote scientific communication. Open science increasingly also refers to open governance and more democratized engagement and control of science…

  15. Open-ended education

    DEFF Research Database (Denmark)

    Nørgård, Rikke Toft; Paaskesen, Rikke Berggreen

    2016-01-01

    THE ARTICLE DESCRIBES OPEN-ENDED EDUCATION FOR 21ST CENTURY LEARNING AS THE COMING TOGETHER OF OPEN-ENDED TECHNOLOGY, OPEN-ENDED PROJECTS, AND OPEN-ENDED INSTITUTIONS IN WAYS THAT FOSTER AND PROMOTE FUTURE EDUCATION FOR CITIZENSHIP IN SOCIETY. THROUGH THE CASE OF THE CODING PIRATES FUTURE ISLAND......, THE ARTICLE DEMONSTRATES HOW OPEN-ENDED EDUCATION CAN BE PRACTICED TO FOSTER AND PROMOTE TECHNOLOGICAL IMAGINATION, ENTERPRISING, AND PARTICIPATION. THIS PRACTICE IS THEN DEVELOPED INTO A THEORETICAL MODEL FOR THE CONCEPT OF OPEN-ENDED EDUCATION AS A WAY OF AND FRAMEWORK FOR PRACTICING FUTURE EDUCATION FOR 21......ST CENTURY LEARNING WITH NEW TECHNOLOGIES. THE ARTICLE PRESENTS AN ANSWER TO THE CALL FOR 21ST CENTURY LEARNING AS THOROUGHLY COLLABORATIVE, COMMUNICATIVE, CREATIVE, AND CRITICALLY REFLECTIVE THROUGH THE CASE AND THE CONCEPT OF OPEN-ENDED EDUCATION. IT OUTLINES THE IMPLICATIONS OF THIS CALL...

  16. Open algebraic surfaces

    CERN Document Server

    Miyanishi, Masayoshi

    2000-01-01

    Open algebraic surfaces are a synonym for algebraic surfaces that are not necessarily complete. An open algebraic surface is understood as a Zariski open set of a projective algebraic surface. There is a long history of research on projective algebraic surfaces, and there exists a beautiful Enriques-Kodaira classification of such surfaces. The research accumulated by Ramanujan, Abhyankar, Moh, and Nagata and others has established a classification theory of open algebraic surfaces comparable to the Enriques-Kodaira theory. This research provides powerful methods to study the geometry and topology of open algebraic surfaces. The theory of open algebraic surfaces is applicable not only to algebraic geometry, but also to other fields, such as commutative algebra, invariant theory, and singularities. This book contains a comprehensive account of the theory of open algebraic surfaces, as well as several applications, in particular to the study of affine surfaces. Prerequisite to understanding the text is a basic b...

  17. Open Access @ DTU

    DEFF Research Database (Denmark)

    Ekstrøm, Jeannette

    Open Access is high on the agenda in Denmark and internationally. Denmark has announced a national strategy for Open Access that aims to achieve Open Access to 80% in 2017 and 100% in 2022 to peer review research articles. All public Danish funders as well as H2020 requires that all peer review...... articles that is an outcome of their funding will be Open Access. Uploading your full texts (your final author manuscript after review ) to DTU Orbit is a fundamental part of providing Open Access to your research. We are here to answer all your questions with regards to Open Access and related topics...... such as copyright, DTU Orbit, Open Access journals, APCs, Vouchers etc....

  18. Open-ended education

    DEFF Research Database (Denmark)

    Nørgård, Rikke Toft; Paaskesen, Rikke Berggreen

    2016-01-01

    THE ARTICLE DESCRIBES OPEN-ENDED EDUCATION FOR 21ST CENTURY LEARNING AS THE COMING TOGETHER OF OPEN-ENDED TECHNOLOGY, OPEN-ENDED PROJECTS, AND OPEN-ENDED INSTITUTIONS IN WAYS THAT FOSTER AND PROMOTE FUTURE EDUCATION FOR CITIZENSHIP IN SOCIETY. THROUGH THE CASE OF THE CODING PIRATES FUTURE ISLAND......, THE ARTICLE DEMONSTRATES HOW OPEN-ENDED EDUCATION CAN BE PRACTICED TO FOSTER AND PROMOTE TECHNOLOGICAL IMAGINATION, ENTERPRISING, AND PARTICIPATION. THIS PRACTICE IS THEN DEVELOPED INTO A THEORETICAL MODEL FOR THE CONCEPT OF OPEN-ENDED EDUCATION AS A WAY OF AND FRAMEWORK FOR PRACTICING FUTURE EDUCATION FOR 21......ST CENTURY LEARNING WITH NEW TECHNOLOGIES. THE ARTICLE PRESENTS AN ANSWER TO THE CALL FOR 21ST CENTURY LEARNING AS THOROUGHLY COLLABORATIVE, COMMUNICATIVE, CREATIVE, AND CRITICALLY REFLECTIVE THROUGH THE CASE AND THE CONCEPT OF OPEN-ENDED EDUCATION. IT OUTLINES THE IMPLICATIONS OF THIS CALL...

  19. OpenSHS: Open Smart Home Simulator

    Directory of Open Access Journals (Sweden)

    Nasser Alshammari

    2017-05-01

    Full Text Available This paper develops a new hybrid, open-source, cross-platform 3D smart home simulator, OpenSHS, for dataset generation. OpenSHS offers an opportunity for researchers in the field of the Internet of Things (IoT and machine learning to test and evaluate their models. Following a hybrid approach, OpenSHS combines advantages from both interactive and model-based approaches. This approach reduces the time and efforts required to generate simulated smart home datasets. We have designed a replication algorithm for extending and expanding a dataset. A small sample dataset produced, by OpenSHS, can be extended without affecting the logical order of the events. The replication provides a solution for generating large representative smart home datasets. We have built an extensible library of smart devices that facilitates the simulation of current and future smart home environments. Our tool divides the dataset generation process into three distinct phases: first design: the researcher designs the initial virtual environment by building the home, importing smart devices and creating contexts; second, simulation: the participant simulates his/her context-specific events; and third, aggregation: the researcher applies the replication algorithm to generate the final dataset. We conducted a study to assess the ease of use of our tool on the System Usability Scale (SUS.

  20. Transmissible endoplasmic reticulum stress from myocardiocytes to macrophages is pivotal for the pathogenesis of CVB3-induced viral myocarditis

    Science.gov (United States)

    Zhang, Hui; Yue, Yan; Sun, Tianle; Wu, Xuejie; Xiong, Sidong

    2017-01-01

    Infiltrating macrophages have been proven as a pivotal pathological inflammatory cell subset in coxsackievirus B3 (CVB3) induced viral myocarditis. However, the mechanisms underlying the initiation and promotion of macrophage pro-inflammatory responses are still blur. We previously reported that cardiac ER stress contributed to CVB3-induced myocarditis by augmenting inflammation. In this study, we focused on the influence of ER stress on the macrophage inflammatory responses in the viral myocarditis. We found that ER stress was robustly induced in the cardiac infiltrating macrophages from CVB3-infected mice, and robustly facilitated the production of pro-inflammatory cytokines (IL-6, IL-12, MCP-1 and IP-10). Consistently, adoptive transfer of ER stressed macrophages significantly worsened the viral myocarditis; while transfer of ER stress-inhibited macrophages obviously alleviated the myocarditis. To our surprise, this significantly activated ER stress was not directly caused by the virus stimulation, but was transferred from the CVB3-infected, ER stressed myocardiocytes via soluble molecules in a TLR2, 4-independent way. In the present study, we reported that the transmissible ER stress from the infected myocardiocytes to macrophages could augment the pro-inflammatory responses and promoted the pathogenesis of viral myocarditis. Blocking ER stress transmission, instead of inhibiting its initiation, may represent novel therapeutic strategies against viral myocarditis. PMID:28176833

  1. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver.

    Science.gov (United States)

    Zhao, Yunze; Zhou, Jie; Liu, Dan; Dong, Fang; Cheng, Hui; Wang, Weili; Pang, Yakun; Wang, Yajie; Mu, Xiaohuan; Ni, Yanli; Li, Zhuan; Xu, Huiyu; Hao, Sha; Wang, Xiaochen; Ma, Shihui; Wang, Qian-fei; Xiao, Guozhi; Yuan, Weiping; Liu, Bing; Cheng, Tao

    2015-11-19

    The fetal liver (FL) serves as a predominant site for expansion of functional hematopoietic stem cells (HSCs) during mouse embryogenesis. However, the mechanisms for HSC development in FL remain poorly understood. In this study, we demonstrate that deletion of activating transcription factor 4 (ATF4) significantly impaired hematopoietic development and reduced HSC self-renewal in FL. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region was not affected. The migration activity of ATF4(-/-) HSCs was moderately reduced. Interestingly, the HSC-supporting ability of both endothelial and stromal cells in FL was significantly compromised in the absence of ATF4. Gene profiling using RNA-seq revealed downregulated expression of a panel of cytokines in ATF4(-/-) stromal cells, including angiopoietin-like protein 3 (Angptl3) and vascular endothelial growth factor A (VEGFA). Addition of Angptl3, but not VEGFA, partially rescued the repopulating defect of ATF4(-/-) HSCs in the culture. Furthermore, chromatin immunoprecipitation assay in conjunction with silencing RNA-mediated silencing and complementary DNA overexpression showed transcriptional control of Angptl3 by ATF4. To summarize, ATF4 plays a pivotal role in functional expansion and repopulating efficiency of HSCs in developing FL, and it acts through upregulating transcription of cytokines such as Angptl3 in the microenvironment.

  2. Simultaneous Five-axis Motion for Identifying Geometric Deviations Through Simulation in Machining Centers with a Double Pivot Head

    Science.gov (United States)

    Dassanayake, Muditha; Yamamoto, Ken; Tsutsumi, Masaomi; Saito, Akinori; Mikami, Shigetaka

    In this paper, simultaneous five-axis control motions were newly proposed to identify the ten inherent deviations to double pivot head type five-axis machines. This motion was designed for the application of a ball bar to the measurements. The ball bar can be applied to the motion by changing the ball bar's sensitive direction in the axial, radial and tangential directions in relation to the A-axis rotation. All the three ball bar settings can be changed in a single arrangement, with a magnetic clamp fixed onto the main spindle. This leads to reduce the setting errors and setting time as well. The ten deviations are identified by using three measurements, two of which are taken in the axial direction motion while the third is extracted using the tangential or radial direction motion. From the axial direction motion, seven deviations are estimated; four of these estimations are made using the observation equation while the other three are made using simple geometric relations. The remaining three of the ten deviations are determined by using tangential or radial motion. The validity of the proposed method is confirmed by simulations.

  3. Ultrasensitive colorimetric detection of circulating tumor DNA using hybridization chain reaction and the pivot of triplex DNA

    Science.gov (United States)

    Li, Ruimin; Zou, Li; Luo, Yanwei; Zhang, Manjun; Ling, Liansheng

    2017-03-01

    This work presents an amplified colorimetric biosensor for circulating tumor DNA (ctDNA), which associates the hybridization chain reaction (HCR) amplification with G-Quadruplex DNAzymes activity through triplex DNA formation. In the presence of ctDNA, HCR occurs. The resulting HCR products are specially recognized by one sequence to include one GGG repeat and the other containing three GGG repeats, through the synergetic effect of triplex DNA and asymmetrically split G-Quadruplex forming. Such design takes advantage of the amplification property of HCR and the high peroxidase-like catalytic activity of asymmetrically split G-Quadruplex DNAzymes by means of triplex DNA formation, which produces color signals in the presence of ctDNA. Nevertheless, in the absence of ctDNA, no HCR happens. Thus, no triplex DNA and G-Quadruplex structure is formed, producing a negligible background. The colorimetric sensing platform is successfully applied in complex biological environments such as human blood plasma for ctDNA detection, with a detection limit corresponding to 0.1 pM. This study unambiguously uses triplex DNA forming as the pivot to integrate nucleic acid amplification and DNAzymes for producing a highly sensitive signal with low background.

  4. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.

    Science.gov (United States)

    Goldmann, Tobias; Wieghofer, Peter; Müller, Philippe F; Wolf, Yochai; Varol, Diana; Yona, Simon; Brendecke, Stefanie M; Kierdorf, Katrin; Staszewski, Ori; Datta, Moumita; Luedde, Tom; Heikenwalder, Mathias; Jung, Steffen; Prinz, Marco

    2013-11-01

    Microglia are brain macrophages and, as such, key immune-competent cells that can respond to environmental changes. Understanding the mechanisms of microglia-specific responses during pathologies is hence vital for reducing disease burden. The definition of microglial functions has so far been hampered by the lack of genetic in vivo approaches that allow discrimination of microglia from closely related peripheral macrophage populations in the body. Here we introduce a mouse experimental system that specifically targets microglia to examine the role of a mitogen-associated protein kinase kinase kinase (MAP3K), transforming growth factor (TGF)-β-activated kinase 1 (TAK1), during autoimmune inflammation. Conditional depletion of TAK1 in microglia only, not in neuroectodermal cells, suppressed disease, significantly reduced CNS inflammation and diminished axonal and myelin damage by cell-autonomous inhibition of the NF-κB, JNK and ERK1/2 pathways. Thus, we found TAK1 to be pivotal in CNS autoimmunity, and we present a tool for future investigations of microglial function in the CNS.

  5. Infection by Toxoplasma gondii Specifically Induces Host c-Myc and the Genes This Pivotal Transcription Factor Regulates

    Science.gov (United States)

    Franco, Magdalena; Shastri, Anjali J.

    2014-01-01

    Toxoplasma gondii infection has previously been described to cause dramatic changes in the host transcriptome by manipulating key regulators, including STATs, NF-κB, and microRNAs. Here, we report that Toxoplasma tachyzoites also mediate rapid and sustained induction of another pivotal regulator of host cell transcription, c-Myc. This induction is seen in cells infected with all three canonical types of Toxoplasma but not the closely related apicomplexan parasite Neospora caninum. Coinfection of cells with both Toxoplasma and Neospora still results in an increase in the level of host c-Myc, showing that c-Myc is actively upregulated by Toxoplasma infection (rather than repressed by Neospora). We further demonstrate that this upregulation may be mediated through c-Jun N-terminal protein kinase (JNK) and is unlikely to be a nonspecific host response, as heat-killed Toxoplasma parasites do not induce this increase and neither do nonviable parasites inside the host cell. Finally, we show that the induced c-Myc is active and that transcripts dependent on its function are upregulated, as predicted. Hence, c-Myc represents an additional way in which Toxoplasma tachyzoites have evolved to specifically alter host cell functions during intracellular growth. PMID:24532536

  6. Open Data and Beyond

    Directory of Open Access Journals (Sweden)

    Frederika Welle Donker

    2016-04-01

    Full Text Available In recent years, there has been an increasing trend of releasing public sector information as open data. Governments worldwide see the potential benefits of opening up their data. The potential benefits are more transparency, increased governmental efficiency and effectiveness, and external benefits, including societal and economic benefits. The private sector also recognizes potential benefits of making their datasets available as open data. One such company is Liander, an energy network administrator in the Netherlands. Liander views open data as a contributing factor to energy conservation. However, to date there has been little research done into the actual effects of open data. This research has developed a monitoring framework to assess the effects of open data, and has applied the framework to Liander’s small-scale energy consumption dataset.

  7. Open port sampling interface

    Energy Technology Data Exchange (ETDEWEB)

    Van Berkel, Gary J

    2017-04-25

    A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate, the first volumetric flow rate exceeding the second volumetric flow rate, wherein liquid at the open end will receive sample, liquid containing sample material will be drawn into and through the liquid exhaust conduit, and liquid will overflow from the open end.

  8. The Effect of Pivotal Response Treatment in Children with Autism Spectrum Disorders: A Non-Randomized Study with a Blinded Outcome Measure

    Science.gov (United States)

    Duifhuis, E. A.; den Boer, J. C.; Doornbos, A.; Buitelaar, J. K.; Oosterling, I. J.; Klip, H.

    2017-01-01

    Purpose of this quasi-experimental trial was to investigate the effect of Pivotal response treatment (PRT) versus treatment as usual (TAU) on autism symptoms. Children with autism spectrum disorder (ASD), aged 3-8 years, received either PRT (n = 11) or TAU (n = 13). Primary outcome measure was the total score on the Autism Diagnostic Observation…

  9. Increasing Opportunities for Question-Asking in School-Aged Children with Autism Spectrum Disorder: Effectiveness of Staff Training in Pivotal Response Treatment

    Science.gov (United States)

    Verschuur, Rianne; Huskens, Bibi; Verhoeven, Ludo; Didden, Robert

    2017-01-01

    Deficits in question-asking are common in children with autism spectrum disorder (ASD). Furthermore, their opportunities to self-initiate questions are often hindered by directive behavior of their conversation partners. This study assessed the effectiveness of staff training in pivotal response treatment (PRT) on staff member-created…

  10. A Randomized Clinical Trial Comparison between Pivotal Response Treatment (PRT) and Adult-Driven Applied Behavior Analysis (ABA) Intervention on Disruptive Behaviors in Public School Children with Autism

    Science.gov (United States)

    Mohammadzaheri, Fereshteh; Koegel, Lynn Kern; Rezaei, Mohammad; Bakhshi, Enayatolah

    2015-01-01

    Children with autism often demonstrate disruptive behaviors during demanding teaching tasks. Language intervention can be particularly difficult as it involves social and communicative areas, which are challenging for this population. The purpose of this study was to compare two intervention conditions, a naturalistic approach, Pivotal Response…

  11. Open-mindedness

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Open-mindness1 is a much-valued2 quality of human being. We value such a quality, because it is good to society as a whole. Almost all the great men are marked with such a quality. It is the openness to things new and strange. Open-minded person is willing toconsider new opinions, new arguments and new way of doing things.

  12. Opening and Closing in Open Systems.

    Science.gov (United States)

    Klapp, Orrin E.

    In open information systems, such as in the case of human interchange with the self and the environment, input quantities have no upper limits. The human information utilization system, however, is psychologically and behaviorally unable to accept ever increasing loads of information. Because of this apparent fact, human information systems should…

  13. Visitors speak openly on the Open Day

    CERN Multimedia

    2004-01-01

    On Open Day, CERN was filled with visitors from around Europe—and beyond—who toured the LHC detector sites and visited a multitude of experimental halls and workshops across the Meyrin and Prevessin sites, the vast majority in buildings normally closed to the public.

  14. Open3DQSAR

    DEFF Research Database (Denmark)

    Tosco, Paolo; Balle, Thomas

    2011-01-01

    Open3DQSAR is a freely available open-source program aimed at chemometric analysis of molecular interaction fields. MIFs can be imported from different sources (GRID, CoMFA/CoMSIA, quantum-mechanical electrostatic potential or electron density grids) or generated by Open3DQSAR itself. Much focus...... has been put on automation through the implementation of a scriptable interface, as well as on high computational performance achieved by algorithm parallelization. Flexibility and interoperability with existing molecular modeling software make Open3DQSAR a powerful tool in pharmacophore assessment...

  15. Open data for citizens

    DEFF Research Database (Denmark)

    Götzen, Amalia De; Morelli, Nicola

    2016-01-01

    A large quantity of open data is now available to institutions, business and citizens. The potential of such new resource, though, has not been explored yet, also because of a lack of perspectives and scenarios on how open data can be used. The workshop aims at broadening the perspectives...... on the use of open data by investigating new scenarios for a wide use of open data, where citizens without any IT skills can be involved in a co-design session with the relevant stakeholders....

  16. Open data assessment

    Science.gov (United States)

    Trifonov, Roumen; Yoshinov, Radoslav; Jekov, Boyan; Pavlova, Galya

    2017-06-01

    The last decade together with rapidly developing of Information and Communication Technologies data and its variety of application fields gaining in popularity. Initially the data becomes Big. Everyday accumulation of so big amount of data and the possibility to analyze it contributes to the ease of modern life. The curiosity of the world enforces the Big Data to become Open and then to connect the available open data in linked. This article presents the Open data and their implication in different fields. Detailed is examined the quality of Open data as the methodology for its evaluation is presented.

  17. SEMI-OPENNESS AND ALMOST-OPENNESS OF INDUCED MAPPINGS

    Institute of Scientific and Technical Information of China (English)

    HuangXianjiu; ZengFanping; ZhangGengrong

    2005-01-01

    Given a mapping f between continua. Let 2f and C(f) mean the induced mappings between hyperspaces. Relations are studied under the conditions :f is semi-open (almost open, respectively), 2f is semi-open (almost open, respectively) and C(f) is semi-open (almost open, respectively).

  18. Pro OpenSSH

    CERN Document Server

    Stahnke, Michael

    2006-01-01

    SSH, acronym for Secure Socket Shell, is for users and administrators wishing to establish secure communication between disparate networks. 'Pro OpenSSH', authored by two Fortune 100 system administrators, provides readers with a highly practical reference for configuring and deploying OpenSSH in their own environment.

  19. OpenShift cookbook

    CERN Document Server

    Gulati, Shekhar

    2014-01-01

    If you are a web application developer who wants to use the OpenShift platform to host your next big idea but are looking for guidance on how to achieve this, then this book is the first step you need to take. This is a very accessible cookbook where no previous knowledge of OpenShift is needed.

  20. Open Data and Beyond

    NARCIS (Netherlands)

    Welle Donker, Frederika; Loenen, Van Bastiaan; Bregt, Arnold

    2016-01-01

    In recent years, there has been an increasing trend of releasing public sector information as open data. Governments worldwide see the potential benefits of opening up their data. The potential benefits are more transparency, increased governmental efficiency and effectiveness, and external

  1. OpenJDK cookbook

    CERN Document Server

    Kasko, Alex; Mironchenko, Alexey

    2015-01-01

    If you are an experienced Java developer using Java 7 platform and want to get your grips on OpenJDK for Java development, this is the book for you. JDK users who wish to migrate to OpenJDK will find this book very useful.

  2. Open Rotor Aeroacoustic Modelling

    Science.gov (United States)

    Envia, Edmane

    2012-01-01

    Owing to their inherent fuel efficiency, there is renewed interest in developing open rotor propulsion systems that are both efficient and quiet. The major contributor to the overall noise of an open rotor system is the propulsor noise, which is produced as a result of the interaction of the airstream with the counter-rotating blades. As such, robust aeroacoustic prediction methods are an essential ingredient in any approach to designing low-noise open rotor systems. To that end, an effort has been underway at NASA to assess current open rotor noise prediction tools and develop new capabilities. Under this effort, high-fidelity aerodynamic simulations of a benchmark open rotor blade set were carried out and used to make noise predictions via existing NASA open rotor noise prediction codes. The results have been compared with the aerodynamic and acoustic data that were acquired for this benchmark open rotor blade set. The emphasis of this paper is on providing a summary of recent results from a NASA Glenn effort to validate an in-house open noise prediction code called LINPROP which is based on a high-blade-count asymptotic approximation to the Ffowcs-Williams Hawkings Equation. The results suggest that while predicting the absolute levels may be difficult, the noise trends are reasonably well predicted by this approach.

  3. Open Data and Beyond

    NARCIS (Netherlands)

    Welle Donker, Frederika; Loenen, Van Bastiaan; Bregt, Arnold

    2016-01-01

    In recent years, there has been an increasing trend of releasing public sector information as open data. Governments worldwide see the potential benefits of opening up their data. The potential benefits are more transparency, increased governmental efficiency and effectiveness, and external benefits

  4. Open G(2) strings

    NARCIS (Netherlands)

    de Boer, J.; de Medeiros, P.; El-Showk, S.; Sinkovics, A.

    2008-01-01

    We consider an open string version of the topological twist previously proposed for sigma-models with G(2) target spaces. We determine the cohomology of open strings states and relate these to geometric deformations of calibrated submanifolds and to flat or anti-self-dual connections on such submani

  5. Bisimilarity of Open Terms

    NARCIS (Netherlands)

    Rensink, Arend; Palamidessi, C.; Parrow, J.

    1997-01-01

    The standard way of lifting a binary relation, R, from closed terms of an algebra to open terms is to define its closed-instance extension, R_{ci}, which holds for a given pair of open terms if and only if R holds for all their closed instantiations. In this paper, we study alternatives for the case

  6. Creating Open Source Conversation

    Science.gov (United States)

    Sheehan, Kate

    2009-01-01

    Darien Library, where the author serves as head of knowledge and learning services, launched a new website on September 1, 2008. The website is built with Drupal, an open source content management system (CMS). In this article, the author describes how she and her colleagues overhauled the library's website to provide an open source content…

  7. Open source community organization

    CSIR Research Space (South Africa)

    Molefe, Onkgopotse M

    2009-05-01

    Full Text Available Open Source communities (OSCs), sometimes referred to as virtual or online communities play a significant role in terms of the contribution they continue to make in producing user-friendly Open Source Software (OSS) solutions. Many projects have...

  8. Open Verlinde line operators

    CERN Document Server

    Gaiotto, Davide

    2014-01-01

    We reformulate the action of Verlinde line operators on conformal blocks in a 3d TFT language and extend it to line operators labelled by open paths joining punctures on the Riemann surface. We discuss the possible applications of open Verlinde line operators to quantum Teichm\\"uller theory, supersymmetric gauge theory and quantum groups

  9. All channels open

    NARCIS (Netherlands)

    Frank Huysmans; Jos de Haan

    2010-01-01

    Original title: Alle kanalen staan open. The rapid changes taking place in the media landscape in the Netherlands - characterised by digitisation and convergence of media technologies - raise the question of how the Dutch are dealing with the many new opportunities that have opened up. All channels

  10. Mastering OpenStack

    CERN Document Server

    Khedher, Omar

    2015-01-01

    This book is intended for system administrators, cloud engineers, and system architects who want to deploy a cloud based on OpenStack in a mid- to large-sized IT infrastructure. If you have a fundamental understanding of cloud computing and OpenStack and want to expand your knowledge, then this book is an excellent checkpoint to move forward.

  11. OpenStack essentials

    CERN Document Server

    Radez, Dan

    2015-01-01

    If you need to get started with OpenStack or want to learn more, then this book is your perfect companion. If you're comfortable with the Linux command line, you'll gain confidence in using OpenStack.

  12. Open Access policy effectiveness

    OpenAIRE

    Swan, Alma

    2015-01-01

    This presentation discusses the policy elements that are necessary for an effective open access policy, according to the findings of the analysis of the revamped ROARMAP tool for open access policies by PASTEUR4OA. It contains graphs, charts and numbers for evidence-based arguments

  13. Creating Open Source Conversation

    Science.gov (United States)

    Sheehan, Kate

    2009-01-01

    Darien Library, where the author serves as head of knowledge and learning services, launched a new website on September 1, 2008. The website is built with Drupal, an open source content management system (CMS). In this article, the author describes how she and her colleagues overhauled the library's website to provide an open source content…

  14. The Open Access Divide

    Directory of Open Access Journals (Sweden)

    Jingfeng Xia

    2013-10-01

    Full Text Available This paper is an attempt to review various aspects of the open access divide regarding the difference between those academics who support free sharing of data and scholarly output and those academics who do not. It provides a structured description by adopting the Ws doctrines emphasizing such questions as who, what, when, where and why for information-gathering. Using measurable variables to define a common expression of the open access divide, this study collects aggregated data from existing open access as well as non-open access publications including journal articles and extensive reports. The definition of the open access divide is integrated into the discussion of scholarship on a larger scale.

  15. Open-Minded Cognition.

    Science.gov (United States)

    Price, Erika; Ottati, Victor; Wilson, Chase; Kim, Soyeon

    2015-11-01

    The present research conceptualizes open-minded cognition as a cognitive style that influences how individuals select and process information. An open-minded cognitive style is marked by willingness to consider a variety of intellectual perspectives, values, opinions, or beliefs-even those that contradict the individual's opinion. An individual's level of cognitive openness is expected to vary across domains (such as politics and religion). Four studies develop and validate a novel measure of open-minded cognition, as well as two domain-specific measures of religious and political open-minded cognition. Exploratory and confirmatory factor analysis (controlling for acquiescence bias) are used to develop the scales in Studies 1 to 3. Study 4 demonstrates that these scales possess convergent and discriminant validity. Study 5 demonstrates the scale's unique predictive validity using the outcome of Empathic Concern (Davis, 1980). Study 6 demonstrates the scale's unique predictive validity using the outcomes of warmth toward racial, religious, and sexual minorities.

  16. Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas

    Directory of Open Access Journals (Sweden)

    Cong D

    2015-08-01

    Full Text Available Dan Cong,1 Mengzi He,2 Silin Chen,2 Xiaoli Liu,1 Xiaodong Liu,2 Hui Sun11Jilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, People’s Republic of China–Japan Union Hospital, 2Key Laboratory of Radiobiology (Ministry of Health, School of Public Health, Jilin University, Changchun, Jilin, People’s Republic of ChinaAbstract: In the present study, we analyzed microRNA (miRNA and gene expression profiles using 499 papillary thyroid carcinoma (PTC samples and 58 normal thyroid tissues obtained from The Cancer Genome Atlas database. A pivotal regulatory network of 18 miRNA and 16 targets was identified. Upregulated miRNAs (miR-222, miR-221, miR-146b, miR-181a/b/d, miR-34a, and miR-424 and downregulated miRNAs (miR-9-1, miR-138, miR-363, miR-20b, miR-195, and miR-152 were identified. Among them, the upregulation of miR-424 and downregulation of miR-363, miR-195, and miR-152 were not previously identified. The genes CCNE2 (also known as cyclin E2, E2F1, RARA, CCND1 (cyclin D1, RUNX1, ITGA2, MET, CDKN1A (p21, and COL4A1 were overexpressed, and AXIN2, TRAF6, BCL2, RARB, HSP90B1, FGF7, and PDGFRA were downregulated. Among them, CCNE2, COL4A1, TRAF6, and HSP90B1 were newly identified. Based on receiver operating characteristic curves, several miRNAs (miR-222, miR-221, and miR-34a and genes (CCND1 and MET were ideal diagnostic indicators, with sensitivities and specificities greater than 90%. The combination of inversely expressed miRNAs and targets improved diagnostic accuracy. In a clinical feature analysis, several miRNAs (miR-34a, miR-424, miR-20b, and miR-152 and genes (CCNE2, COL4A1, TRAF6, and HSP90B1 were associated with aggressive clinical features, which have not previously been reported. Our study not only identified a pivotal miRNA regulatory network associated with PTC but also provided evidence that miRNAs and target genes can be used as biomarkers in PTC diagnosis and clinical

  17. Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

    Science.gov (United States)

    Marinković, Aleksandar; Mih, Justin D.; Park, Jin-Ah; Liu, Fei

    2012-01-01

    Lung fibroblast functions such as matrix remodeling and activation of latent transforming growth factor-β1 (TGF-β1) are associated with expression of the myofibroblast phenotype and are directly linked to fibroblast capacity to generate force and deform the extracellular matrix. However, the study of fibroblast force-generating capacities through methods such as traction force microscopy is hindered by low throughput and time-consuming procedures. In this study, we improved at the detail level methods for higher-throughput traction measurements on polyacrylamide hydrogels using gel-surface-bound fluorescent beads to permit autofocusing and automated displacement mapping, and transduction of fibroblasts with a fluorescent label to streamline cell boundary identification. Together these advances substantially improve the throughput of traction microscopy and allow us to efficiently compute the forces exerted by lung fibroblasts on substrates spanning the stiffness range present in normal and fibrotic lung tissue. Our results reveal that lung fibroblasts dramatically alter the forces they transmit to the extracellular matrix as its stiffness changes, with very low forces generated on matrices as compliant as normal lung tissue. Moreover, exogenous TGF-β1 selectively accentuates tractions on stiff matrices, mimicking fibrotic lung, but not on physiological stiffness matrices, despite equivalent changes in Smad2/3 activation. Taken together, these results demonstrate a pivotal role for matrix mechanical properties in regulating baseline and TGF-β1-stimulated contraction of lung fibroblasts and suggest that stiff fibrotic lung tissue may promote myofibroblast activation through contractility-driven events, whereas normal lung tissue compliance may protect against such feedback amplification of fibroblast activation. PMID:22659883

  18. Pivotal Role of PGE2 and IL-10 in the Cross-Regulation of Dendritic Cell-Derived Inflammatory Mediators

    Institute of Scientific and Technical Information of China (English)

    Hedi Harizi; Norbert Gualde

    2006-01-01

    Exposure to pathogens induces antigen-presenting cells (APC) such as macrophages and dendritic cells (DC) to produce various endogenous mediators, including arachidonic acid (AA)-derived eicosanoids, cytokines, and nitric oxide (NO). Many secreted products of activated APC can act by themselves in an autocrine manner and modulate their function. Moreover, the cross-interaction between endogenous bioactive molecules regulates the function of professional APC with important consequences for their ability to activate and sustain immune and inflammatory responses, and to regulate immune homeostasis. Although neglected for many years when compared to their role in cardiovascular homeostasis, cancer and inflammation, the importance of eicosanoids in immunology is becoming more defined. The role of prostaglandin (PG) E2 (PGE2), one of the best known and most well studied eicosanoids,is of particular interest. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. Uniquely among haematopoietic cytokines, interleukin-10 (IL-10) is a pleiotropic molecule that displays both immunostimulatory and immunoregulatory activities. IL-10 has attached much attention because of its anti-inflammatory properties. It modulates expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, particularly macrophages and DC. We previously reported that PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC), and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. BM-DC may be considered as an important model to study complex interactions between endogenous mediators, and autocrine IL-10 plays a pivotal role in the crossregulation of AA-derived lipid mediators, cytokines, and NO, with critical effects on immune and inflammatory responses. Cellular & Molecular Immunology. 2006;3(4):271-277.

  19. Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release

    Directory of Open Access Journals (Sweden)

    Robert A. Hauser

    2014-01-01

    Full Text Available Background. The minimal clinically important difference (MCID is the smallest change in an outcome measure that is meaningful for patients. Objectives. To calculate the MCID for Unified Parkinson’s Disease Rating Scale (UPDRS scores in early Parkinson’s disease (EPD and for UPDRS scores and “OFF” time in advanced Parkinson’s disease (APD. Methods. We analyzed data from two pivotal, double-blind, parallel-group trials of pramipexole ER that included pramipexole immediate release (IR as an active comparator. We calculated MCID as the mean change in subjects who received active treatment and rated themselves “a little better” on patient global impression of improvement (PGI-I minus the mean change in subjects who received placebo and rated themselves unchanged. Results. MCIDs in EPD (pramipexole ER, pramipexole IR for UPDRS II were −1.8 and −2.0, for UPDRS III −6.2 and −6.1, and for UPDRS II + III −8.0 and −8.1. MCIDs in APD for UPDRS II were −1.8 and −2.3, for UPDRS III −5.2 and −6.5, and for UPDRS II + III −7.1 and −8.8. MCID for “OFF” time (pramipexole ER, pramipexole IR was −1.0 and −1.3 hours. Conclusions. A range of MCIDs is emerging in the PD literature that provides the basis for power calculations and interpretation of clinical trials.

  20. Open innovation with an effective open innovation team.

    OpenAIRE

    Vanvoorden, Jonas

    2014-01-01

    This master's thesis explores how open innovation teams can successfully support open innovation inside of an organisation. Open innovation is a paradigm introduced by Henry Chesbrough (2003) a decade ago. It expands the innovation potential of organisations by opening them up to new ways of working with external partners. To implement open innovation, many companies rely on a small group of managers named open innovation teams. Although open innovation teams can potentially be vital for impl...

  1. Demystifying Open Access

    Energy Technology Data Exchange (ETDEWEB)

    Mele, Salvatore (CERN)

    2007-05-30

    The tenets of Open Access are to grant anyone, anywhere and anytime free access to the results of scientific research. HEP spearheaded the Open Access dissemination of scientific results with the mass mailing of preprints in the pre-WWW era and with the launch of the arXiv preprint system at the dawn of the '90s. The HEP community is now ready for a further push to Open Access which retains all the advantages of the peer-review system and, at the same time, brings the spiraling cost of journal subscriptions under control. I will present a possible plan for the conversion to Open Access of HEP peer-reviewed journals, through a consortium of HEP funding agencies, laboratories and libraries: SCOAP3 (Sponsoring Consortium for Open Access Publishing in Particle Physics). SCOAP3 will engage with scientific publishers towards building a sustainable model for Open Access publishing, which is as transparent as possible for HEP authors. In this talk I will present a short overview of the history of Open Access in HEP, the details of the SCOAP3 model and the outlook for its implementation.

  2. OpenNI cookbook

    CERN Document Server

    Falahati, Soroush

    2013-01-01

    This is a Cookbook with plenty of practical recipes enriched with explained code and relevant screenshots to ease your learning curve. If you are a beginner or a professional in NIUI and want to write serious applications or games, then this book is for you. Even OpenNI 1 and OpenNI 1.x programmers who want to move to new versions of OpenNI can use this book as a starting point. This book uses C++ as the primary language but there are some examples in C# and Java too, so you need to have about a basic working knowledge of C or C++ for most cases.

  3. Linking open vocabularies

    CERN Document Server

    Greifender, Elke; Seadle, Michael

    2013-01-01

    Linked Data (LD), Linked Open Data (LOD) and generating a web of data, present the new knowledge sharing frontier. In a philosophical context, LD is an evolving environment that reflects humankinds' desire to understand the world by drawing on the latest technologies and capabilities of the time. LD, while seemingly a new phenomenon did not emerge overnight; rather it represents the natural progression by which knowledge structures are developed, used, and shared. Linked Open Vocabularies is a significant trajectory of LD. Linked Open Vocabularies targets vocabularies that have traditionally b

  4. Open Media Science

    DEFF Research Database (Denmark)

    Møller Moltke Martiny, Kristian; Pedersen, David Budtz; Hansted, Allan Alfred Birkegaard

    2016-01-01

    In this article, we present three challenges to the emerging Open Science (OS) movement: the challenge of communication, collaboration and cultivation of scientific research. We argue that to address these challenges OS needs to include other forms of data than what can be captured in a text...... and extend into a fully-fledged Open Media movement engaging with new media and non-traditional formats of science communication. We discuss two cases where experiments with open media have driven new collaborations between scientists and documentarists. We use the cases to illustrate different advantages...

  5. Open3DGRID

    DEFF Research Database (Denmark)

    Tosco, Paolo; Balle, Thomas

    2011-01-01

    Description Open3DGRID is an open-source software aimed at high-throughput generation of molecular interaction fields (MIFs). Open3DGRID can generate steric potential, electron density and MM/QM electrostatic potential fields; furthermore, it can import GRIDKONT binary files produced by GRID and Co......, Solaris x86 32/64-bit, FreeBSD 32/64-bit, Intel Mac OS X 32/64-bit), source code is portable and can be compiled under any *NIX platform supporting POSIX threads. The modular nature of the code allows for easy implementation of new features, so that the core application can be customized to meet...

  6. Open Access Policy

    OpenAIRE

    University of East London, .

    2013-01-01

    The University of East London is committed to and supports open access to its research publications.\\ud There is a worldwide move towards free and unrestricted access to research publications, with benefits\\ud for researchers, universities and wider society. UEL supports this initiative and recognises the\\ud importance of open access in increasing the visibility and impact of research. This policy is aligned with\\ud and supports HEFCE’s Policy for Open Access in the Post‐2014 REF, and is alig...

  7. Open Media Science

    DEFF Research Database (Denmark)

    Møller Moltke Martiny, Kristian; Pedersen, David Budtz; Hansted, Allan Alfred Birkegaard

    2016-01-01

    In this article, we present three challenges to the emerging Open Science (OS) movement: the challenge of communication, collaboration and cultivation of scientific research. We argue that to address these challenges OS needs to include other forms of data than what can be captured in a text...... and extend into a fully-fledged Open Media movement engaging with new media and non-traditional formats of science communication. We discuss two cases where experiments with open media have driven new collaborations between scientists and documentarists. We use the cases to illustrate different advantages...

  8. Commentary: open access, open business, closed fairness!

    Science.gov (United States)

    Moustafa, Khaled

    2015-01-01

    A strong trend to move from print to online publication is largely perceived in scientific and nonscientific fields. A growing number of publishers increasingly opt for online publication as an option or a compulsory alternative. From readers' perspective, this is a highly appreciated facility, but from the author's, things are different mainly because of excessive article processing charges (APC) that make the open access system sometimes as a hindrance for many authors but a lucrative enterprise for many shareholders, enticing the most traditional and conservative publishers.

  9. Reframing Open Big Data

    DEFF Research Database (Denmark)

    Marton, Attila; Avital, Michel; Jensen, Tina Blegind

    2013-01-01

    ’, these developments introduce an unprecedented level of societal and organizational engagement with the potential of computational data to generate new insights and information. Based on the commonalities shared by open data and big data, we develop a research framework that we refer to as open big data (OBD......Recent developments in the techniques and technologies of collecting, sharing and analysing data are challenging the field of information systems (IS) research let alone the boundaries of organizations and the established practices of decision-making. Coined ‘open data’ and ‘big data......) by employing the dimensions of ‘order’ and ‘relationality’. We argue that these dimensions offer a viable approach for IS research on open and big data because they address one of the core value propositions of IS; i.e. how to support organizing with computational data. We contrast these dimensions with two...

  10. Special restaurant opening times

    CERN Multimedia

    HR Department

    2008-01-01

    1-EASTER Restaurant No. 1 (Novae) will be closed from Friday, 21 March to Monday, 24 March inclusive and will re-open at 7.00 a.m. on Tuesday, 25 March. Restaurant No. 2 (DSR) will remain open during the four days in question (the opening hours can be consulted at: http://resto2.web.cern.ch/resto2/Events/easter2008.html 2-ASCENSION Restaurant No. 2 (DSR) will be closed from Thursday, 1st May to Friday, 2 May. Restaurant No. 2 (Novae) will remain open during the two days in question (from 7.00 a.m. to 10.00 p.m. on the Thursday and from 7.00 till midnight, as usual, on the Friday).

  11. Open Hardware at CERN

    CERN Multimedia

    CERN Knowledge Transfer Group

    2015-01-01

    CERN is actively making its knowledge and technology available for the benefit of society and does so through a variety of different mechanisms. Open hardware has in recent years established itself as a very effective way for CERN to make electronics designs and in particular printed circuit board layouts, accessible to anyone, while also facilitating collaboration and design re-use. It is creating an impact on many levels, from companies producing and selling products based on hardware designed at CERN, to new projects being released under the CERN Open Hardware Licence. Today the open hardware community includes large research institutes, universities, individual enthusiasts and companies. Many of the companies are actively involved in the entire process from design to production, delivering services and consultancy and even making their own products available under open licences.

  12. Open cycle thermoacoustics

    Energy Technology Data Exchange (ETDEWEB)

    Reid, Robert Stowers [Georgia Inst. of Technology, Atlanta, GA (United States)

    2000-01-01

    A new type of thermodynamic device combining a thermodynamic cycle with the externally applied steady flow of an open thermodynamic process is discussed and experimentally demonstrated. The gas flowing through this device can be heated or cooled in a series of semi-open cyclic steps. The combination of open and cyclic flows makes possible the elimination of some or all of the heat exchangers (with their associated irreversibility). Heat is directly exchanged with the process fluid as it flows through the device when operating as a refrigerator, producing a staging effect that tends to increase First Law thermodynamic efficiency. An open-flow thermoacoustic refrigerator was built to demonstrate this concept. Several approaches are presented that describe the physical characteristics of this device. Tests have been conducted on this refrigerator with good agreement with a proposed theory.

  13. Privacy and Open Government

    Directory of Open Access Journals (Sweden)

    Teresa Scassa

    2014-06-01

    Full Text Available The public-oriented goals of the open government movement promise increased transparency and accountability of governments, enhanced citizen engagement and participation, improved service delivery, economic development and the stimulation of innovation. In part, these goals are to be achieved by making more and more government information public in reusable formats and under open licences. This paper identifies three broad privacy challenges raised by open government. The first is how to balance privacy with transparency and accountability in the context of “public” personal information. The second challenge flows from the disruption of traditional approaches to privacy based on a collapse of the distinctions between public and private sector actors. The third challenge is that of the potential for open government data—even if anonymized—to contribute to the big data environment in which citizens and their activities are increasingly monitored and profiled.

  14. Summer Restaurant opening times

    CERN Multimedia

    2015-01-01

    Restaurant No. 1: Open as usual in July and August. Open from 7 a.m. to 10 p.m. on Thursday, 10 September (Jeûne genevois).   Restaurant No. 2: Open as usual in July and August. Closed on Thursday, 10 September (Jeûne genevois) and Friday, 11 September. The Brasserie (table service) will be closed from Monday, 4 August to Friday, 11 September.   Restaurant No. 3: Open as usual in July and August, but closed on Saturday, 1 August; Saturday, 15 August; Thursday, 10 September (Jeûne genevois); and Friday, 11 September.   Snack bar in Building 54: Closed from Monday, 4 August to Friday, 11 September.   Snack bars in Buildings 13, 30 and 6: Closed on Thursday, 10 September (Jeûne genevois) and Friday, 11 September.

  15. Reframing Open Big Data

    DEFF Research Database (Denmark)

    Marton, Attila; Avital, Michel; Jensen, Tina Blegind

    2013-01-01

    Recent developments in the techniques and technologies of collecting, sharing and analysing data are challenging the field of information systems (IS) research let alone the boundaries of organizations and the established practices of decision-making. Coined ‘open data’ and ‘big data......’, these developments introduce an unprecedented level of societal and organizational engagement with the potential of computational data to generate new insights and information. Based on the commonalities shared by open data and big data, we develop a research framework that we refer to as open big data (OBD......) by employing the dimensions of ‘order’ and ‘relationality’. We argue that these dimensions offer a viable approach for IS research on open and big data because they address one of the core value propositions of IS; i.e. how to support organizing with computational data. We contrast these dimensions with two...

  16. Trade Openness and Inequality

    Directory of Open Access Journals (Sweden)

    Nasfi Fkili Wahiba

    2013-12-01

    Full Text Available This paper is intended to test the effect of trade openness on inequality of wage distribution in Tunisia. The study through econometric estimates showed that the impact of openness on inequality is remarkable in the period marked by an intensive integration into the global economy. However, investment in human capital can have a positive effect and leas to reduce wage disparities. Opening to the world economy is able to achieve positive economic performance, except that one of the challenges for Tunisia is to find the best equilibrium between the benefits and costs of this policy. Globalization can be beneficial for the economy, but the debate is open about its impact on the social level, many are those who accuse it of increasing disparities and inequalities between workers.

  17. The Open Access Divide

    National Research Council Canada - National Science Library

    Jingfeng Xia

    2013-01-01

      This paper is an attempt to review various aspects of the open access divide regarding the difference between those academics who support free sharing of data and scholarly output and those academics who do...

  18. ON REICH'S OPEN QUESTION

    Institute of Scientific and Technical Information of China (English)

    张石生

    2003-01-01

    Under more general form and more general conditions an affirmative answer to Reich's open question is given. The results presented also extend and improve some recent results of Reich, Shioji, Takahashi and Wittmann.

  19. Opening the Floodgates

    DEFF Research Database (Denmark)

    Wessel, Michael; Thies, Ferdinand; Benlian, Alexander

    2017-01-01

    Managing platform ecosystems requires providers to govern the permeability of platform boundaries in order to strike a balance between openness and control. But is it worthwhile for platform providers to conduct screening processes for third-party offerings, or should they rather apply a laissez......,000 crowdfunding campaigns with a combined funding of over $1.9 billion that cover a 4-year period around the policy change, we find that increasing platform openness was a double-edged sword for the platform’s ecosystem. While Kickstarter’s revenue from commissions surged after the policy change due...... uncertainties as project creators invest less in reducing information asymmetries. Our evidence from this natural experiment therefore suggests that increasing platform openness for third-party offerings can destabilize a platform’s ecosystem. We thus extend the literature on platform openness...

  20. Open3DALIGN

    DEFF Research Database (Denmark)

    Tosco, Paolo; Balle, Thomas

    2011-01-01

    of the dataset either the single conformation originally imported or the conformational databases previously obtained by QMD. Additionally, SDF conformational databases can be easily imported from external conformational engines such as MOE and OMEGA. In the latter case, the conformers which best fit...... application can be customized to meet individual needs. A detailed ChangeLog is kept to keep track of the additions and modifications during Open3DALIGN's development.......Description Open3DALIGN is an open-source software aimed at unsupervised molecular alignment. Open3DALIGN is a command-line tool which is operated by means of a few commands which can be entered interactively from a command prompt, read from a batch script or piped through standard input. If Py...

  1. Official Antimonopoly Website Opens

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin

    2011-01-01

    @@ China's antimonopoly law website opened in December 19, 2009.Netizens can log in at http://www.antimonopolylaw.org to see the update information of indepth anti-monopoly law theory and case studies, according to the organizer.

  2. Opening up codings?

    DEFF Research Database (Denmark)

    Steensig, Jakob; Heinemann, Trine

    2015-01-01

    We welcome Tanya Stivers’s discussion (Stivers, 2015/this issue) of coding social interaction and find that her descriptions of the processes of coding open up important avenues for discussion, among other things of the precise ad hoc considerations that researchers need to bear in mind, both when....... Instead we propose that the promise of coding-based research lies in its ability to open up new qualitative questions....

  3. Funding open access

    Science.gov (United States)

    Sprouse, Gene D.; Zimmermann, Frank

    2009-03-01

    We were happy to see the 10-year anniversary of our open-access journal Physical Review Special Topics: Accelerators and Beams (PRST-AB) mentioned in your news article on open-access publishing (December 2008 pp13-14). However, your statement that PRST-AB "is funded by US national labs, whose researchers publish about 150 papers per year in the journal" is not entirely correct.

  4. Open source molecular modeling.

    Science.gov (United States)

    Pirhadi, Somayeh; Sunseri, Jocelyn; Koes, David Ryan

    2016-09-01

    The success of molecular modeling and computational chemistry efforts are, by definition, dependent on quality software applications. Open source software development provides many advantages to users of modeling applications, not the least of which is that the software is free and completely extendable. In this review we categorize, enumerate, and describe available open source software packages for molecular modeling and computational chemistry. An updated online version of this catalog can be found at https://opensourcemolecularmodeling.github.io.

  5. Demystifying Open Access

    Energy Technology Data Exchange (ETDEWEB)

    Mele, Salvatore

    2007-05-14

    The tenets of Open Access are to grant anyone, anywhere and anytime free access to the results of scientific research. HEP spearheaded the Open Access dissemination of scientific results with the mass mailing of preprints in the pre-WWW era and with the launch of the arXiv preprint system at the dawn of the '90s. The HEP community is now ready for a further push to Open Access while retaining all the advantages of the peer-review system and, at the same time, bring the spiralling cost of journal subscriptions under control. I will present a possible plan for the conversion to Open Access of HEP peer-reviewed journals, through a consortium of HEP funding agencies, laboratories and libraries: SCOAP3 (Sponsoring Consortium for Open Access Publishing in Particle Physics). SCOAP3 will engage with scientific publishers towards building a sustainable model for Open Access publishing, which is as transparent as possible for HEP authors. The current system in which journals income comes from subscription fees is replaced with a scheme where SCOAP3 compensates publishers for the costs incurred to organise the peer-review service and give Open Access to the final version of articles. SCOAP3 will be funded by all countries active in HEP under a 'fair share' scenario, according to their production of HEP articles. In this talk I will present a short overview of the history of Open Access in HEP, the details of the SCOAP3 model and the outlook for its implementation.

  6. Open Access Publishing

    Directory of Open Access Journals (Sweden)

    Amelia Hadfield

    2013-07-01

    Full Text Available The rise of open source online journals, free online courses, and other changes in the research and education environment, coined the "academic spring" by some commentators, represents an increasing trend in opening up the rules of access for research. Universities, libraries, publishers and even govern­ments are paying attention to this new movement often referred to with the acronym A2K (access to knowledge.

  7. Open for Entrepreneurship

    DEFF Research Database (Denmark)

    Eftekhari, Nazanin; Bogers, Marcel

    2015-01-01

    This paper explores how an open approach to new venture creation - purposefully managing knowledge flows across the venture's organizational boundary - can be beneficial for start-up entrepreneurs. Our inductive case study, of both failure and success, identifies the key attributes of this open...... for entrepreneurship and innovation research and practice, providing some attention points for researchers, entrepreneurs, investors and policy makers interested in developing successful new ventures....

  8. Setting efficiency indicators for center pivots Ajuste de indicadores de eficiência para pivôs centrais

    Directory of Open Access Journals (Sweden)

    Ricardo L. Schons

    2012-06-01

    Full Text Available In this study, it was discussed the efficiency criteria in each of the elements that compose a central pivot, and this analysis was applied to two sets of systems located in regions of Cruz Alta and Santo Augusto, state of Rio Grande do Sul, Brazil. The methodology used combines water and energy assessment through an indicator called Normalized Specific Consumption in Irrigation (C ENI, allowing thus a comparison between equipment and projects. The C ENI in Cruz Alta region showed 72% of the equipment above the standard (8.68 kWh mm-1 ha-1 100m-1, and in Santo Augusto region 64.28% with consumption above the standard. The mean irrigation efficiency for Cruz Alta region was 29.85%, with standard deviation of 5.41%, and for Santo Augusto region, it was 29.02%, with standard deviation of 5.15%.Neste trabalho, são discutidos critérios de eficiência em cada um dos elementos que compõem um pivô central, sendo esta análise aplicada a dois conjuntos de sistemas localizados, nas regiões de Cruz Alta e Santo Augusto, Rio Grande do Sul. A metodologia utilizada associa as avaliações hídrica e energética por meio de um indicador denominado Consumo Específico Normalizado na Irrigação (C ENI, possibilitando, desta forma, uma comparação entre equipamentos e entre projetos. O C ENI na região de Cruz Alta apresentou 72% dos equipamentos acima do padrão (8,68 kWh mm-1 ha-1 100m-1, e na região de Santo Augusto, 64,28% com o consumo acima do padrão. A eficiência de irrigação média para a região de Cruz Alta foi de 29,85%, com desvio-padrão de 5,41%; e para a Região de Santo Augusto foi de 29,02%, com desvio padrão de 5,15%.

  9. Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

    Science.gov (United States)

    Houde, Martin; Jamain, Marc-David; Labonté, Julie; Desbiens, Louisane; Pejler, Gunnar; Gurish, Michael; Takai, Shinji; D'Orléans-Juste, Pedro

    2013-07-01

    The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II) from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1-31) from Big-ET-1. Although humans possess only one chymase, several murine isoforms are documented, each with its own specific catalytic activity. Among these, mouse mast cell protease 4 (mMCP-4) is the isoform most similar to the human chymase for its activity. The aim of this study was to characterize the capacity of mMCP-4 to convert Big-ET-1 into its bioactive metabolite, ET-1, in vitro and in vivo in the mouse model. Basal mean arterial pressure did not differ between wild-type (WT) and mMCP-4(-/-) mice. Systemic administration of Big-ET-1 triggered pressor responses and increased blood levels of immunoreactive (IR) ET-1 (1-31) and ET-1 that were reduced by more than 50% in mMCP-4 knockout (-/-) mice compared with WT controls. Residual responses to Big-ET-1 in mMCP-4(-/-) mice were insensitive to the enkephalinase/neutral endopeptidase inhibitor thiorphan and the specific chymase inhibitor TY-51469 {2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid}. Soluble fractions from the lungs, left cardiac ventricle, aorta, and kidneys of WT but not mMCP-4(-/-) mice generated ET-1 (1-31) from exogenous Big-ET-1 in a TY-51469-sensitive fashion as detected by high-performance liquid chromatography/ matrix-assisted laser desorption/ionization-mass spectrometry. Finally, pulmonary endogenous levels of IR-ET-1 were reduced by more than 40% in tissues derived from mMCP-4(-/-) mice compared with WT mice. Our results show that mMCP-4 plays a pivotal role in the dynamic conversion of systemic Big-ET-1 to ET-1 in the mouse model.

  10. Pivotal role of the muscle-contraction pathway in cryptorchidism and evidence for genomic connections with cardiomyopathy pathways in RASopathies

    KAUST Repository

    Cannistraci, Carlo

    2013-02-14

    Background: Cryptorchidism is the most frequent congenital disorder in male children; however the genetic causes of cryptorchidism remain poorly investigated. Comparative integratomics combined with systems biology approach was employed to elucidate genetic factors and molecular pathways underlying testis descent. Methods. Literature mining was performed to collect genomic loci associated with cryptorchidism in seven mammalian species. Information regarding the collected candidate genes was stored in MySQL relational database. Genomic view of the loci was presented using Flash GViewer web tool (http://gmod.org/wiki/Flashgviewer/). DAVID Bioinformatics Resources 6.7 was used for pathway enrichment analysis. Cytoscape plug-in PiNGO 1.11 was employed for protein-network-based prediction of novel candidate genes. Relevant protein-protein interactions were confirmed and visualized using the STRING database (version 9.0). Results. The developed cryptorchidism gene atlas includes 217 candidate loci (genes, regions involved in chromosomal mutations, and copy number variations) identified at the genomic, transcriptomic, and proteomic level. Human orthologs of the collected candidate loci were presented using a genomic map viewer. The cryptorchidism gene atlas is freely available online: http://www.integratomics-time.com/cryptorchidism/. Pathway analysis suggested the presence of twelve enriched pathways associated with the list of 179 literature-derived candidate genes. Additionally, a list of 43 network-predicted novel candidate genes was significantly associated with four enriched pathways. Joint pathway analysis of the collected and predicted candidate genes revealed the pivotal importance of the muscle-contraction pathway in cryptorchidism and evidence for genomic associations with cardiomyopathy pathways in RASopathies. Conclusions: The developed gene atlas represents an important resource for the scientific community researching genetics of cryptorchidism. The

  11. The Open AUC Project.

    Science.gov (United States)

    Cölfen, Helmut; Laue, Thomas M; Wohlleben, Wendel; Schilling, Kristian; Karabudak, Engin; Langhorst, Bradley W; Brookes, Emre; Dubbs, Bruce; Zollars, Dan; Rocco, Mattia; Demeler, Borries

    2010-02-01

    Progress in analytical ultracentrifugation (AUC) has been hindered by obstructions to hardware innovation and by software incompatibility. In this paper, we announce and outline the Open AUC Project. The goals of the Open AUC Project are to stimulate AUC innovation by improving instrumentation, detectors, acquisition and analysis software, and collaborative tools. These improvements are needed for the next generation of AUC-based research. The Open AUC Project combines on-going work from several different groups. A new base instrument is described, one that is designed from the ground up to be an analytical ultracentrifuge. This machine offers an open architecture, hardware standards, and application programming interfaces for detector developers. All software will use the GNU Public License to assure that intellectual property is available in open source format. The Open AUC strategy facilitates collaborations, encourages sharing, and eliminates the chronic impediments that have plagued AUC innovation for the last 20 years. This ultracentrifuge will be equipped with multiple and interchangeable optical tracks so that state-of-the-art electronics and improved detectors will be available for a variety of optical systems. The instrument will be complemented by a new rotor, enhanced data acquisition and analysis software, as well as collaboration software. Described here are the instrument, the modular software components, and a standardized database that will encourage and ease integration of data analysis and interpretation software.

  12. Business Models for Open Innovation

    DEFF Research Database (Denmark)

    Saebi, Tina; Foss, Nicolai Juul

    of open business models by systematically linking open innovation strategies to core business model dimensions, notably the content, structure, governance of transactions. We further illustrate a continuum of open innovativeness, differentiating between four types of open business models. We contribute......Research on open innovation suggests that companies benefit differentially from adopting open innovation strategies; however, it is unclear why this is so. One possible explanation is that companies’ business models are not attuned to open strategies. Accordingly, we propose a contingency model...... to the open innovation literature by specifying the conditions under which business models are conducive to the success of open innovation strategies....

  13. Business Models for Open Innovation

    DEFF Research Database (Denmark)

    Saebi, Tina; Foss, Nicolai J.

    2015-01-01

    of open business models by systematically linking open innovation strategies to core business model dimensions, notably the content, structure, governance of transactions. We further illustrate a continuum of open innovativeness, differentiating between four types of open business models. We contribute......Research on open innovation suggests that companies benefit differentially from adopting open innovation strategies; however, it is unclear why this is so. One possible explanation is that companies' business models are not attuned to open strategies. Accordingly, we propose a contingency model...... to the open innovation literature by specifying the conditions under which business models are conducive to the success of open innovation strategies....

  14. Evaluation and analysis of the energetic efficiency of center pivot irrigation systems; Avaliacao e analise da eficiencia energetica na irrigacao em sistemas pivo central

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Aureo C. de [Universidade Federal da Grande Dourados (UFGD), Dourados, MS (Brazil). Unidade II], email: aureolima@ufgd.edu.br; Guimaraes Junior, Sebastiao C.; Camacho, Jose R. [Universidade Federal de Uberlandia (UFU), MG (Brazil). Nucleo de Energia Rural e Fontes Alternativas de Energia], emails: scguimaes@ufu.br, jrcamacho@ufu.br; Fietz, Carlos R. [EMBRAPA Agropecuaria Oeste, Dourados, MS (Brazil)], email: fietz@cpao.embrapa.br

    2009-07-01

    With an irrigated area of approximately 710,500 ha in Brazil, it is possible to estimate an annual electricity consumption of 1,928 G Wh per year due to center pivot systems. Considering the need of optimization of the irrigated agricultural production, the energies that are dissipated in the suction pipes, water supply, lateral lines and sprinkler systems are analyzed in this study and an equation is proposed to determine the useful power of center pivot irrigation systems. Three center pivot systems located in Itamarati I (a Government settlement for the landless in the city of Ponta Pora, State of Mato Grosso do Sul, Brazil) were evaluated and measures of energetic efficiency were simulated in order to determine a viable economic configuration to meet the life span of the equipment. The systems were characterized by the energy use and results show that the average irrigation energetic efficiency may be raised from 14.9 to 25.9% leading to a possible reduction of R$ 118,800 per year over 7,200 ha, equivalent to 11% of the yearly expenses with electricity of the whole area. (author)

  15. UK Open Access Policy Landscape

    OpenAIRE

    Picarra, Mafalda

    2014-01-01

    Two distinct paths for open access are being promoted in UK open access policies: open access publishing (gold open access) by RCUK (Gold OA) and self-archiving (green open access) by HEFCE. This requires continuous and coordinated efforts to support universities, academic libraries and researchers in achieving compliance.

  16. Open Day: General Information

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ With 50 visit points, including theatre performances, debates and visits to installations that have never before been opened to the public, CERN's 50th anniversary Open Day is set to be a day to remember. Seven hundred volunteers have signed up to help for the day. The Open Day team truly appreciates this wonderful show of support! The Open Day would not be possible without their help. Car parking and Access Cars with a CERN sticker can access all CERN sites as normal. However, to avoid congestion on Meyrin site, we ask you to park in areas that will not be open to the public (see below) and to use the shuttle services wherever possible for your transport during the day. Private cars on the French side of the border without a CERN sticker will be diverted to a car park area in the Prévessin site. There is a shuttle service connecting the Meyrin and Prévessin sites via SM18 every 20 minutes. Private cars on the Swiss side of the border without a CERN sticker will be diverte...

  17. CERN: Digitally open, too

    CERN Multimedia

    Computer Security Team

    2013-01-01

    The Open Days are here!! From tomorrow onwards, we will be welcoming thousands of people to CERN. No barriers, no boundaries!   For decades, we have welcomed researchers and visitors from around the world to work at CERN, discuss physics research and attend our training sessions, lectures and conferences. This is how fundamental research should be conducted!!! But have you ever noticed how you are welcome at CERN in the digital world, too? Once you are affiliated and are registered with CERN, you receive a CERN computing account and e-mail address.  You can register your laptops, PCs and smartphones to use our (wireless) network, you can easily create your personal webpage, and profit from a vast disk space for file storage (AFS and DFS). CERN is indeed an Open Campus and not only during the Open Days. CERN is an Open Campus in the digital world. This digital Open Campus culture is exactly the reason why “computer security” has been dele...

  18. Global OpenSearch

    Science.gov (United States)

    Newman, D. J.; Mitchell, A. E.

    2015-12-01

    At AGU 2014, NASA EOSDIS demonstrated a case-study of an OpenSearch framework for Earth science data discovery. That framework leverages the IDN and CWIC OpenSearch API implementations to provide seamless discovery of data through the 'two-step' discovery process as outlined by the Federation for Earth Sciences (ESIP) OpenSearch Best Practices. But how would an Earth Scientist leverage this framework and what are the benefits? Using a client that understands the OpenSearch specification and, for further clarity, the various best practices and extensions, a scientist can discovery a plethora of data not normally accessible either by traditional methods (NASA Earth Data Search, Reverb, etc) or direct methods (going to the source of the data) We will demonstrate, via the CWICSmart web client, how an earth scientist can access regional data on a regional phenomena in a uniform and aggregated manner. We will demonstrate how an earth scientist can 'globalize' their discovery. You want to find local data on 'sea surface temperature of the Indian Ocean'? We can help you with that. 'European meteorological data'? Yes. 'Brazilian rainforest satellite imagery'? That too. CWIC allows you to get earth science data in a uniform fashion from a large number of disparate, world-wide agencies. This is what we mean by Global OpenSearch.

  19. Open Source Telecommunication Companies

    Directory of Open Access Journals (Sweden)

    Peter Liu

    2007-08-01

    Full Text Available Little is known about companies whose core business is selling telecommunications products that lever open source projects. Open source telecommunications (OST companies operate in markets that are very different from typical software product markets. The telecommunications market is regulated, vertically integrated, and proprietary designs and special chips are widely used. For a telecommunications product to be useful, it must interact with both access network products and core network products. Due to specifications in Service Agreements Levels, penalties for failures of telecommunications products are very high. This article shares information that is not widely known, including a list of OST companies and the open source projects on which they depend, the size and diversity of venture capital investment in OST companies, the nature of the commercial product-open source software and company-project relationships, ways in which OST companies make money, benefits and risks of OST companies, and competition between OST companies. Analysis of this information provides insights into the ways in which companies can build business models around open source software. These findings will be of interest to entrepreneurs, top management teams of incumbent companies that sell telecommunications products, and those who care about Ontario's ability to compete globally.

  20. Open3DALIGN

    DEFF Research Database (Denmark)

    Tosco, Paolo; Balle, Thomas

    2011-01-01

    Description Open3DALIGN is an open-source software aimed at unsupervised molecular alignment. Open3DALIGN is a command-line tool which is operated by means of a few commands which can be entered interactively from a command prompt, read from a batch script or piped through standard input. If Py...... systems (Windows 32/64-bit, Linux 32/64-bit, Solaris x86 32/64-bit, FreeBSD 32/64-bit, Intel Mac OS X 32/64-bit), source code is portable and can be compiled under any *NIX platform supporting POSIX threads. The modular nature of the code allows for easy implementation of new features, so that the core...

  1. Support open access publishing

    DEFF Research Database (Denmark)

    Ekstrøm, Jeannette

    2013-01-01

    Projektet Support Open Access Publishing har til mål at få opdateret Sherpa/Romeo databasen (www.sherpa.ac.uk/romeo) med fagligt relevante, danske tidsskrifter. Projektet skal endvidere undersøge mulighederne for at få udviklet en database, hvor forskere på tværs af relevante tidsskriftsinformati......Projektet Support Open Access Publishing har til mål at få opdateret Sherpa/Romeo databasen (www.sherpa.ac.uk/romeo) med fagligt relevante, danske tidsskrifter. Projektet skal endvidere undersøge mulighederne for at få udviklet en database, hvor forskere på tværs af relevante...... tidsskriftsinformationer (faglig disciplin, BFI niveau, Impact Factor, Open Access) vil kunne danne sig et hurtigt overblik, for derved at kunne træffe et kvalificeret valg om, hvor og hvordan man skal publicere sine forskningsresultater....

  2. New gate opening hours

    CERN Multimedia

    GS Department

    2009-01-01

    Please note the new opening hours of the gates as well as the intersites tunnel from the 19 May 2009: GATE A 7h - 19h GATE B 24h/24 GATE C 7h - 9h\t17h - 19h GATE D 8h - 12h\t13h - 16h GATE E 7h - 9h\t17h - 19h Prévessin 24h/24 The intersites tunnel will be opened from 7h30 to 18h non stop. GS-SEM Group Infrastructure and General Services Department

  3. Open Day at SHMI.

    Science.gov (United States)

    Jarosova, M.

    2010-09-01

    During the World Meteorological Day there has been preparing "Open Day" at Slovak Hydrometeorological Institute. This event has more than 10 years traditions. "Open Day" is one of a lot of possibilities to give more information about meteorology, climatology, hydrology too to public. This "Day" is executed in whole Slovakia. People can visit the laboratories, the forecasting room....and meteo and clima measuring points. The most popular is visiting forecasting room. Visitors are interested in e.g. climatologic change in Slovakia territory, preparing weather forecasting, dangerous phenomena.... Every year we have more than 500 visitors.

  4. Using OpenRefine

    CERN Document Server

    Verborgh, Ruben

    2013-01-01

    The book is styled on a Cookbook, containing recipes - combined with free datasets - which will turn readers into proficient OpenRefine users in the fastest possible way.This book is targeted at anyone who works on or handles a large amount of data. No prior knowledge of OpenRefine is required, as we start from the very beginning and gradually reveal more advanced features. You don't even need your own dataset, as we provide example data to try out the book's recipes.

  5. Gates Wide Open

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China vows to further open up its market to spur international and domestic economic development China’s entry into the WTO 10 years a go was a major step in the country’s reform and opening up. It indicated the "beginning of a new historic stage"in the country’s interaction with the rest of the world, said Chinese President Hu Jintao, at a high-level forum marking the 10th anniversary of China’s accession to the

  6. Ready to be Open?

    DEFF Research Database (Denmark)

    Monteiro, L. Felipe; Mol, Michael J.; Birkinshaw, Julian

    2016-01-01

    suggest that a firm's lack of resources and absorptive capacity, as well as its use of secrecy, are significant barriers to benefiting from openness to external knowledge. Using responses from 12,152 firms to the fourth and fifth UK versions of the Community Innovation Survey (CIS), we generate findings......This paper provides new theory and evidence about the benefits of openness on a firm's innovation performance and, more importantly, the specific firm-level contingencies under which those benefits are more (or less) likely to be observed. Building on Dyer and Singh's (1998) relational view, we...

  7. Ready to be Open?

    DEFF Research Database (Denmark)

    Monteiro, L. Felipe; Mol, Michael J.; Birkinshaw, Julian

    suggest that a firm's lack of resources and absorptive capacity, as well as its use of secrecy, are significant barriers to benefiting from openness to external knowledge. Using responses from 12,152 firms to the fourth and fifth UK versions of the Community Innovation Survey (CIS) we generate findings......This paper provides new theory and evidence about the benefits of openness on a firm's innovation performance and, more importantly, the specific firm-level contingencies under which those benefits are more (or less) likely to be observed. Building on Dyer and Singh's (1998) relational view, we...

  8. Torii, an Open Portal over Open Archives

    CERN Document Server

    Bertocco, S

    2001-01-01

    The world of academic publishing is undergoing many changes. Everywhere paper-based publishing is being replaced by electronic archives and ink printing by bits. Unrestricted (web) access to many resources is becoming a fundamental feature of the academic research environment. Particularly in the high-energy physics community, the pre-print distribution has moved completely away from the paper-based system into a fully electronic system based on open archives. At the same time, freely accessible peer-reviewed journals have started to challenge the more traditional, and paper-based journals showing that the entire paper-based cycle can be effectively replaced by a web-based one. The TIPS project was born in this environment and from these observations. It is based on the idea that further progress in information distribution and scientific publishing on the web requires some key ingredients: the implementation of a more extensive semantic structure in the documents that are exchanged; a unified, desktop-like, ...

  9. Building the Open Elements of an Open Data Competition

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Drachsler, Hendrik; Guy, Marieke; Herder, Eelco; Parodi, Elisabetta

    2014-01-01

    The European Union is increasingly committed to pushing forward open approaches as indicated by the G8 Open Data Charter, the Opening Up Education initiative, the launch of the Open Education Europa Portal for OER resources and other similar initiatives. The EU-funded LinkedUp Project (Linking Web d

  10. CERN openlab Open Day

    CERN Multimedia

    Purcell, Andrew Robert

    2015-01-01

    The CERN openlab Open Day took place on 10 June, 2015. This was the first in a series of annual events at which research and industrial teams from CERN openlab can present their projects, share achievements, and collect feedback from their user communities.

  11. Open Source Software Acquisition

    DEFF Research Database (Denmark)

    Holck, Jesper; Kühn Pedersen, Mogens; Holm Larsen, Michael

    2005-01-01

    Lately we have seen a growing interest from both public and private organisations to adopt OpenSource Software (OSS), not only for a few, specific applications but also on a more general levelthroughout the organisation. As a consequence, the organisations' decisions on adoption of OSS arebecoming...

  12. Open source development

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    2004-01-01

    This paper addresses innovations based on open source or non-proprietary knowledge. Viewed through the lens of private property theory, such agency appears to be a true anomaly. However, by a further turn of the theoretical kaleidoscope, we will show that there may be perfectly justifiable reason...

  13. Massive and Open

    Science.gov (United States)

    Fasimpaur, Karen

    2013-01-01

    MOOCs--massive open online courses--are all the rage these days, with hundreds of thousands of participants signing up and investors plunking down millions to get a piece of the pie. Why is there so much excitement about this new disruptive form of online learning, and how does this model apply to professional learning for teachers? Traditional…

  14. Bisimulation from Open Maps

    DEFF Research Database (Denmark)

    Joyal, André; Nielsen, Mogens; Winskel, Glynn

    1996-01-01

    and van Glabeek and Goltz. A tie-up with open maps in a (pre)topos, as they appear in the work of Joyal and Moerdijk, brings to light a new model, presheaves on categories of pomsets, into which the usual category of labelled event structures embeds fully and faithfully. As an indication of its promise...

  15. Bisimulation and open maps

    DEFF Research Database (Denmark)

    Joyal, André; Nielsen, Mogens; Winskel, Glynn

    1993-01-01

    ), and Goltz and van Glabeek (1989). A tie-up with open maps in a (pre)topos brings to light a promising new model, presheaves on categories of pomsets, into which the usual category of labeled event structures embeds fully and faithfully. As an indication of its promise, this new presheaf model has refinement...

  16. Van: An Open Letter

    Science.gov (United States)

    Tieman, John Samuel

    2011-01-01

    This essay is an open letter from a classroom teacher to a concerned citizen. The letter lists a variety of problems caused largely by standardization and the more corrosive effects of positivism. Many of these problems are unknown to those outside the immediate school setting. While the letter focuses on a specific setting, an inner city school…

  17. TIRES, OPEN BURNING

    Science.gov (United States)

    The chapter describes available information on the health effects from open burning of rubber tires. It concentrates on the three known sources of detailed measurements: (1) a small-scale emissions characterization study performed by the U.S. EPA in a facility designed to simulat...

  18. Evaluating Open Source Portals

    Science.gov (United States)

    Goh, Dion; Luyt, Brendan; Chua, Alton; Yee, See-Yong; Poh, Kia-Ngoh; Ng, How-Yeu

    2008-01-01

    Portals have become indispensable for organizations of all types trying to establish themselves on the Web. Unfortunately, there have only been a few evaluative studies of portal software and even fewer of open source portal software. This study aims to add to the available literature in this important area by proposing and testing a checklist for…

  19. Open Source in Education

    Science.gov (United States)

    Lakhan, Shaheen E.; Jhunjhunwala, Kavita

    2008-01-01

    Educational institutions have rushed to put their academic resources and services online, beginning the global community onto a common platform and awakening the interest of investors. Despite continuing technical challenges, online education shows great promise. Open source software offers one approach to addressing the technical problems in…

  20. Open-Source Colorimeter

    Science.gov (United States)

    Anzalone, Gerald C.; Glover, Alexandra G.; Pearce, Joshua M.

    2013-01-01

    The high cost of what have historically been sophisticated research-related sensors and tools has limited their adoption to a relatively small group of well-funded researchers. This paper provides a methodology for applying an open-source approach to design and development of a colorimeter. A 3-D printable, open-source colorimeter utilizing only open-source hardware and software solutions and readily available discrete components is discussed and its performance compared to a commercial portable colorimeter. Performance is evaluated with commercial vials prepared for the closed reflux chemical oxygen demand (COD) method. This approach reduced the cost of reliable closed reflux COD by two orders of magnitude making it an economic alternative for the vast majority of potential users. The open-source colorimeter demonstrated good reproducibility and serves as a platform for further development and derivation of the design for other, similar purposes such as nephelometry. This approach promises unprecedented access to sophisticated instrumentation based on low-cost sensors by those most in need of it, under-developed and developing world laboratories. PMID:23604032

  1. Open-Ended Evolution

    DEFF Research Database (Denmark)

    Taylor, Tim; A. Bedau, Mark; Channon, Alastair

    2016-01-01

    This report describes the First Workshop on Open-Ended Evolution: Recent Progress and Future Milestones (OEE1), held during the ECAL 2015 conference at the University of York, U.K., in July 2015. We briefly summarise the content of the talks and discussions and the workshop, and provide links...

  2. Quasi-open inflation

    CERN Document Server

    García-Bellido, J; Montes, X; Garcia-Bellido, Juan; Garriga, Jaume; Montes, Xavier

    1998-01-01

    We show that a large class of two-field models of single-bubble open inflation do not lead to infinite open universes, as it was previously thought, but to an ensemble of very large but finite inflating `islands'. The reason is that the quantum tunneling responsible for the nucleation of the bubble does not occur simultaneously along both field directions and equal-time hypersurfaces in the open universe are not synchronized with equal-density or fixed-field hypersurfaces. The most probable tunneling trajectory corresponds to a zero value of the inflaton field; large values, necessary for the second period of inflation inside the bubble, only arise as localized fluctuations. The interior of each nucleated bubble will contain an infinite number of such inflating regions of comoving size of order $\\gamma^{-1}$, where $\\gamma$ depends on the parameters of the model. Each one of these islands will be a quasi-open universe. Since the volume of the hyperboloid is infinite, inflating islands with all possible values...

  3. Open Educational Resources

    Science.gov (United States)

    McShane, Michael Q.

    2017-01-01

    While digital products have made significant inroads into the educational resources market, textbooks and other print materials still command about 60 percent of sales. But whether print or digital, all of these commercial offerings now face threats from a burgeoning effort to promote "open" resources for education--that is, materials…

  4. Openers for Biology Classes.

    Science.gov (United States)

    Gridley, C. Robert R.

    This teaching guide contains 200 activities that are suitable for openers and demonstrations in biology classes. Details are provided regarding the use of these activities. Some of the broad topics under which the activities are organized include algae, amphibians, bacteria, biologists, crustaceans, dinosaurs, ecology, evolution, flowering plants,…

  5. Open-Ended Evolution

    DEFF Research Database (Denmark)

    Taylor, Tim; A. Bedau, Mark; Channon, Alastair

    2016-01-01

    This report describes the First Workshop on Open-Ended Evolution: Recent Progress and Future Milestones (OEE1), held during the ECAL 2015 conference at the University of York, U.K., in July 2015. We briefly summarise the content of the talks and discussions and the workshop, and provide links...

  6. The Costs of "Openness"

    Science.gov (United States)

    Cleveland, Harlan

    1975-01-01

    The author argues that very wide consultation tends to discourage innovation and favor stand-pattism and that the very great benefits of openness and wide participation are flawed by apathy and non-participation, by muscle-binding legalisms, by processes which polarize two adversary sides, and by the encouragement of mediocrity. (JT)

  7. KAUST Open Access policy

    KAUST Repository

    Baessa, Mohamed A.

    2017-03-07

    The transition to open access (OA) is being driven by funders, libraries, researchers and publishers around the world, and is having an impact on us all. It is inevitable that different countries, organisations and disciplines are moving at different rates towards an OA model, and it is this that we will focus on in this session. Drawing on experiences from across Europe and the Middle East we will provide perspectives from both a global publisher and institutions based in the region. Taylor & Francis take a flexible, evidence-based approach to open access, providing a choice of publication routes for our authors, and a choice of agreements for our library customers. Carolyn will outline some of the open access developments, opportunities and challenges at Taylor & Francis. The library plays a critical role in facilitating open access for their researchers, from managing a repository to providing support and information on the OA publication process to their authors. Janis Tyhurst and Dr Imad Bachir will each give an overview of how this is being managed by their institution. There will be an opportunity for questions and discussion with the panel.

  8. Official Antimonopoly Website Opens

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin

    2010-01-01

    @@ China's antimonopoly law website opened in December 19, 2009. Netizens can log in at http://www.antimo-nopolylaw.org to see the update information of in-depth anti-monopoly law theory and case studies, according to the organizer.

  9. APS and Open Access

    Science.gov (United States)

    2011-03-01

    The movement toward Open Access continues to gain momentum. A brief review of APS efforts in this area will be presented by APS Editor in Chief, Gene Sprouse. Editors from Physical Review A, B, E, Focus, Letters, and X, Reviews of Modern Physics, and Physics will address your questions about publishing in this evolving environment.

  10. Open inventor and PREMO

    NARCIS (Netherlands)

    Wang, D.; Reynolds, G.J.; Herman, I.

    1996-01-01

    PREMO is an emerging international standard for the presentations of multimedia objects including computer graphics. Open Inventor$^{TM$ is a commercially available ``de facto'' standard for interactive computer graphics packaged as a library of objects. In this report we consider whether the conce

  11. Open Data Reader 2016

    NARCIS (Netherlands)

    M. Brinkerink (Maarten); M. Zeinstra (Maarten); L Kalshoven (Lisette); T Schep (Tijmen)

    2016-01-01

    textabstractIn deze publicatie bekijken we het gecompliceerde veld van open data, waaronder de randvoorwaarden voor het openen van data. We bekijken specifiek drie verschillende facetten van de opendatapraktijk: de juridische kaders, de technologische factoren en de beleidsvorming rondom het actief

  12. BGCI China office opens

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ The official opening ceremony of the China Office of Botanic Gardens Conservation International (BGCI) was held in the CAS South China Botanical Garden (SCBG) in Guangzhou, capital of south China's Guangdong Province, on 26 February. The event brought together more than 100 high-caliber scholars and officials, including Secretary General of BGCI Mme.

  13. The Downside Of Openness

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The opening of China’s financial markets may not be the key to resolving the U.S. trade deficit As an investment banker, Henry Paulson was known for his 70-odd visits to China. Thishigh frequency has been sustained since he took over the U.S. Treasur

  14. IPMACC: Open Source OpenACC to CUDA/OpenCL Translator

    OpenAIRE

    Lashgar, Ahmad; Majidi, Alireza; Baniasadi, Amirali

    2014-01-01

    In this paper we introduce IPMACC, a framework for translating OpenACC applications to CUDA or OpenCL. IPMACC is composed of set of translators translating OpenACC for C applications to CUDA or OpenCL. The framework uses the system compiler (e.g. nvcc) for generating final accelerator's binary. The framework can be used for extending the OpenACC API, executing OpenACC applications, or obtaining CUDA or OpenCL code which is equivalent to OpenACC code. We verify correctness of our framework und...

  15. Beginning the Dialogue on the e-Transformation: Behavior Analysis' First Massive Open Online Course (MOOC).

    Science.gov (United States)

    Rehfeldt, Ruth Anne; Jung, Heidi L; Aguirre, Angelica; Nichols, Jane L; Root, William B

    2016-03-01

    The e-Transformation in higher education, in which Massive Open Online Courses (MOOCs) are playing a pivotal role, has had an impact on the modality in which behavior analysis is taught. In this paper, we survey the history and implications of online education including MOOCs and describe the implementation and results for the discipline's first MOOC, delivered at Southern Illinois University in spring 2015. Implications for the globalization and free access of higher education are discussed, as well as the parallel between MOOCs and Skinner's teaching machines.

  16. Analysis of Open Access Landscape

    Institute of Scientific and Technical Information of China (English)

    Helen Doyle; Andy Gass; Debra Lappin; Rebecca Kennison

    2005-01-01

    This paper is created by bounding 5 editorials of Public Library of Science (PLoS ) which have written on various aspects of open access. It covers wide range topics of important open access issues, such as from paying for open access to copyright to open access as a public issue, which may be more or less of interest of our audience.

  17. Open data and beyond: Exploring existing open data projects to prepare a successful open data strategy; Deelrapport inleiding open data

    NARCIS (Netherlands)

    Van Loenen, B.

    2012-01-01

    Netwerkbedrijf Alliander was begin 2011 zich aan het oriënteren naar de mogelijkheid om haar gegevens als open data ter beschikking te stellen aan een ieder. Echter wat open data nu precies is, welke mogelijke knelpunten moeten worden opgelost om open data te implementeren, de impact die open data z

  18. OpenGL development cookbook

    CERN Document Server

    Movania, Muhammad Mobeen

    2013-01-01

    The book is written in a Cookbook format with practical recipes aimed at helping you exploit OpenGL to its full potential.This book is targeted towards intermediate OpenGL programmers. However, those who are new to OpenGL and know an alternate API like DirectX might also find these recipes useful to create OpenGL animations.

  19. Opening Reproducible Research

    Science.gov (United States)

    Nüst, Daniel; Konkol, Markus; Pebesma, Edzer; Kray, Christian; Klötgen, Stephanie; Schutzeichel, Marc; Lorenz, Jörg; Przibytzin, Holger; Kussmann, Dirk

    2016-04-01

    Open access is not only a form of publishing such that research papers become available to the large public free of charge, it also refers to a trend in science that the act of doing research becomes more open and transparent. When science transforms to open access we not only mean access to papers, research data being collected, or data being generated, but also access to the data used and the procedures carried out in the research paper. Increasingly, scientific results are generated by numerical manipulation of data that were already collected, and may involve simulation experiments that are completely carried out computationally. Reproducibility of research findings, the ability to repeat experimental procedures and confirm previously found results, is at the heart of the scientific method (Pebesma, Nüst and Bivand, 2012). As opposed to the collection of experimental data in labs or nature, computational experiments lend themselves very well for reproduction. Some of the reasons why scientists do not publish data and computational procedures that allow reproduction will be hard to change, e.g. privacy concerns in the data, fear for embarrassment or of losing a competitive advantage. Others reasons however involve technical aspects, and include the lack of standard procedures to publish such information and the lack of benefits after publishing them. We aim to resolve these two technical aspects. We propose a system that supports the evolution of scientific publications from static papers into dynamic, executable research documents. The DFG-funded experimental project Opening Reproducible Research (ORR) aims for the main aspects of open access, by improving the exchange of, by facilitating productive access to, and by simplifying reuse of research results that are published over the Internet. Central to the project is a new form for creating and providing research results, the executable research compendium (ERC), which not only enables third parties to

  20. Beginning Power BI with Excel 2013 self-service business intelligence using Power Pivot, Power View, Power Query, and Power Map

    CERN Document Server

    Clark, Dan

    2014-01-01

    Understanding your company's data has never been easier than with Microsoft's new Power BI package for Excel 2013. Consisting of four powerful tools-Power Pivot, Power View, Power Query and Power Maps-Power BI makes self-service business intelligence a reality for a wide range of users, bridging the traditional gap between Excel users, business analysts and IT experts and making it easier for everyone to work together to build the data models that can give you game-changing insights into your business. Beginning Power BI with Excel 2013 guides you step by step through the process of analyzin

  1. Open architecture CNC system

    Energy Technology Data Exchange (ETDEWEB)

    Tal, J. [Galil Motion Control Inc., Sunnyvale, CA (United States); Lopez, A.; Edwards, J.M. [Los Alamos National Lab., NM (United States)

    1995-04-01

    In this paper, an alternative solution to the traditional CNC machine tool controller has been introduced. Software and hardware modules have been described and their incorporation in a CNC control system has been outlined. This type of CNC machine tool controller demonstrates that technology is accessible and can be readily implemented into an open architecture machine tool controller. Benefit to the user is greater controller flexibility, while being economically achievable. PC based, motion as well as non-motion features will provide flexibility through a Windows environment. Up-grading this type of controller system through software revisions will keep the machine tool in a competitive state with minimal effort. Software and hardware modules are mass produced permitting competitive procurement and incorporation. Open architecture CNC systems provide diagnostics thus enhancing maintainability, and machine tool up-time. A major concern of traditional CNC systems has been operator training time. Training time can be greatly minimized by making use of Windows environment features.

  2. Open Days in 2008

    CERN Multimedia

    Corinne Pralavorio

    CERN will be organising two Open Days in 2008, one for CERN employees and their families on Saturday, 5 April, and another for the general public on Sunday, 6 April. This is the one last chance to see the LHC and its experiments. In addition to the surface facilities, visitors will be able to go underground to see the accelerator and will have acces to the experiment caverns. Exceptionally, most of the points along the ring will be open. We need a large number of volunteers to ensure the success of these two very special days. Full details of the events will be published in the first January edition of the Bulletin. Volunteers will be able to register by completing an electronic form and an information session will be organised.

  3. Occupants' window opening behaviour

    DEFF Research Database (Denmark)

    Fabi, Valentina; Andersen, Rune Korsholm; Corgnati, Stefano

    2012-01-01

    Energy consumption in buildings is influenced by several factors related to the building properties and the building controls, some of them highly connected to the behaviour of their occupants.In this paper, a definition of items referring to occupant behaviour related to the building control...... systems is proposed, based on studies presented in literature and a general process leading to the effects on energy consumptions is identified.Existing studies on the topic of window opening behaviour are highlighted and a theoretical framework to deal with occupants' interactions with building controls......, aimed at improving or maintaining the preferred indoor environmental conditions, is elaborated. This approach is used to look into the drivers for the actions taken by the occupants (windows opening and closing) and to investigate the existing models in literature of these actions for both residential...

  4. Open Source Physics

    CERN Document Server

    Wee, Loo Kang

    2013-01-01

    Open Source Physics (Brown, 2012; Christian, 2010; Esquembre, 2012; Hwang, 2010) empowers teachers and students to create and use these free tools with the associated intellectual property rights given to customise (Wee & Mak, 2009) the computer models/tools to suit their teaching and learning needs. Open Source Physics (OSP) focuses on design of computer models, such as Easy Java Simulations (EJS) and the use of video modeling and analysis (Tracker). They allow students to investigate, explore and analyse data which is either real or simulated. The OSP approach helps users overcome barriers in creating, using and scaling up meaningful ICT use in education. In Singapore, teachers and students have created or customised existing computer models to design and re-purpose EJS models to suit their context and learning needs. Tracker tools allow students to analyse different aspects of a physics phenomena to deepen their understanding of abstract physics concepts. Using Tracker, students record the motion of ob...

  5. Open problems in mathematics

    CERN Document Server

    Nash, Jr, John Forbes

    2016-01-01

    The goal in putting together this unique compilation was to present the current status of the solutions to some of the most essential open problems in pure and applied mathematics. Emphasis is also given to problems in interdisciplinary research for which mathematics plays a key role. This volume comprises highly selected contributions by some of the most eminent mathematicians in the international mathematical community on longstanding problems in very active domains of mathematical research. A joint preface by the two volume editors is followed by a personal farewell to John F. Nash, Jr. written by Michael Th. Rassias. An introduction by Mikhail Gromov highlights some of Nash’s legendary mathematical achievements. The treatment in this book includes open problems in the following fields: algebraic geometry, number theory, analysis, discrete mathematics, PDEs, differential geometry, topology, K-theory, game theory, fluid mechanics, dynamical systems and ergodic theory, cryptography, theoretical computer sc...

  6. Naval open systems architecture

    Science.gov (United States)

    Guertin, Nick; Womble, Brian; Haskell, Virginia

    2013-05-01

    For the past 8 years, the Navy has been working on transforming the acquisition practices of the Navy and Marine Corps toward Open Systems Architectures to open up our business, gain competitive advantage, improve warfighter performance, speed innovation to the fleet and deliver superior capability to the warfighter within a shrinking budget1. Why should Industry care? They should care because we in Government want the best Industry has to offer. Industry is in the business of pushing technology to greater and greater capabilities through innovation. Examples of innovations are on full display at this conference, such as exploring the impact of difficult environmental conditions on technical performance. Industry is creating the tools which will continue to give the Navy and Marine Corps important tactical advantages over our adversaries.

  7. OpenGL VGIS

    Science.gov (United States)

    Faust, Nickolas L.; Bhaumik, Dharmajyoti; Hodges, Larry F.; Ribarsky, William; Koller, David; Lindstrom, Peter

    1996-06-01

    Georgia Tech has developed the Virtual GIS (VGIS) system, a real time visualization system for terrain, image, and geographic information systems (GIS) data sets. The initial systems developed at Georgia Tech were non- realtime, but had fast generation of perspective scenes from multisources data sets and the ability to query for GIS attributes associated with terrain of 3D structures inserted within the terrain. The basic concept of a virtual GIS was implemented in realtime using the Silicon Graphics International graphics language. This system has been extended in capability to allow realtime traversal within a very large geographic database and to show the finest detail information available when it is near to the view point. Extensive work has been done in the management of large arrays of information and the efficient paging of that information into the rendering system. An effective level of detail management system is implemented to dynamically allocate the appropriate amount of detail relative to the viewer location. A major use of this system has been in the area of battlefield visualization. The advent of OpenGL as a defacto standard has now made it possible to provide the VGIS capacity on a number of other platforms, thereby extending its usefulness to other applications and users. OpenGL has been developed as a general purpose Graphics rendering toolkit that will be supported on various computers and special purpose rendering systems. There are hardware and software implementations of OpenGL. This should allow VGIS to operate on many systems, taking advantage of specialized graphics hardware when it is present. This paper addresses the implementation of the VGIS system in OpenGL and the use of the system in driving the Evans and Sutherland Freedom series graphics rendering hardware.

  8. Open access / accesso aperto

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2012-06-01

    Full Text Available Sto collaborando, per la voce Open access, a un e-book a più mani dal titolo Le parole dell’innovazione. Ricorro all’archivio Marini per mettere a disposizione di tutti una versione estesa del mio lemma. Non dice nulla di nuovo rispetto al già noto; può però essere utile a chi sia completamente disinformato sul tema.

  9. Open Flavor Strong Decays

    Science.gov (United States)

    García-Tecocoatzi, H.; Bijker, R.; Ferretti, J.; Galatà, G.; Santopinto, E.

    2016-10-01

    In this contribution, we discuss the results of a QM calculation of the open-flavor strong decays of **** light nucleon resonances. These are the results of a recent calculation, where we used a modified ^3P_0 model for the amplitudes and the U(7) algebraic model and the hypercentral quark model to predict the baryon spectrum. The decay amplitudes are compared with the existing experimental data.

  10. Open quantum system identification

    CERN Document Server

    Schirmer, Sophie G; Zhou, Weiwei; Gong, Erling; Zhang, Ming

    2012-01-01

    Engineering quantum systems offers great opportunities both technologically and scientifically for communication, computation, and simulation. The construction and operation of large scale quantum information devices presents a grand challenge and a major issue is the effective control of coherent dynamics. This is often in the presence of decoherence which further complicates the task of determining the behaviour of the system. Here, we show how to determine open system Markovian dynamics of a quantum system with restricted initialisation and partial output state information.

  11. Diophantine Correct Open Induction

    CERN Document Server

    Raffer, Sidney

    2010-01-01

    We give an induction-free axiom system for diophantine correct open induction. We relate the problem of whether a finitely generated ring of Puiseux polynomials is diophantine correct to a problem about the value-distribution of a tuple of semialgebraic functions with integer arguments. We use this result, and a theorem of Bergelson and Leibman on generalized polynomials, to identify a class of diophantine correct subrings of the field of descending Puiseux series with real coefficients.

  12. Open3DQSAR

    DEFF Research Database (Denmark)

    Tosco, Paolo; Balle, Thomas

    2011-01-01

    into gnuplot. Open3DQSAR is written in C; while pre-built binaries are available for mainstream operating systems (Windows 32/64-bit, Linux 32/64-bit, Solaris x86 32/64-bit, FreeBSD 32/64-bit, Intel Mac OS X 32/64-bit), source code is portable and can be compiled under any *NIX platform supporting POSIX...

  13. Open SHMEM Reference Implementation

    Energy Technology Data Exchange (ETDEWEB)

    2016-05-12

    OpenSHMEM is an effort to create a specification for a standardized API for parallel programming in the Partitioned Global Address Space. Along with the specification the project is also creating a reference implementation of the API. This implementation attempts to be portable, to allow it to be deployed in multiple environments, and to be a starting point for implementations targeted to particular hardware platforms. It will also serve as a springboard for future development of the API.

  14. Open static Chaplygin universe

    CERN Document Server

    Khalatnikov, I M

    2003-01-01

    We apply the qualitative theory of dynamical systems to the study of the Chaplygin gas cosmological model. In difference to earlier works devoted to this model we give up sign restrictions on the choice of the sign of the energy density and on the parameters characterising initial conditions for a cosmological evolution. It appears that exists a static stable open universe filled with the Chaplygin gas. Besides exist universes where the acoustic waves have a velocity exceeding that of light in the vacuum.

  15. Open-Source GIS

    Energy Technology Data Exchange (ETDEWEB)

    Vatsavai, Raju [ORNL; Burk, Thomas E [University of Minnesota; Lime, Steve [Minnesota Department of Natural Resources

    2012-01-01

    The components making up an Open Source GIS are explained in this chapter. A map server (Sect. 30.1) can broadly be defined as a software platform for dynamically generating spatially referenced digital map products. The University of Minnesota MapServer (UMN Map Server) is one such system. Its basic features are visualization, overlay, and query. Section 30.2 names and explains many of the geospatial open source libraries, such as GDAL and OGR. The other libraries are FDO, JTS, GEOS, JCS, MetaCRS, and GPSBabel. The application examples include derived GIS-software and data format conversions. Quantum GIS, its origin and its applications explained in detail in Sect. 30.3. The features include a rich GUI, attribute tables, vector symbols, labeling, editing functions, projections, georeferencing, GPS support, analysis, and Web Map Server functionality. Future developments will address mobile applications, 3-D, and multithreading. The origins of PostgreSQL are outlined and PostGIS discussed in detail in Sect. 30.4. It extends PostgreSQL by implementing the Simple Feature standard. Section 30.5 details the most important open source licenses such as the GPL, the LGPL, the MIT License, and the BSD License, as well as the role of the Creative Commons.

  16. The open boundary equation

    Directory of Open Access Journals (Sweden)

    D. Diederen

    2015-06-01

    Full Text Available We present a new equation describing the hydrodynamics in infinitely long tidal channels (i.e., no reflection under the influence of oceanic forcing. The proposed equation is a simple relationship between partial derivatives of water level and velocity. It is formally derived for a progressive wave in a frictionless, prismatic, tidal channel with a horizontal bed. Assessment of a large number of numerical simulations, where an open boundary condition is posed at a certain distance landward, suggests that it can also be considered accurate in the more natural case of converging estuaries with nonlinear friction and a bed slope. The equation follows from the open boundary condition and is therefore a part of the problem formulation for an infinite tidal channel. This finding provides a practical tool for evaluating tidal wave dynamics, by reconstructing the temporal variation of the velocity based on local observations of the water level, providing a fully local open boundary condition and allowing for local friction calibration.

  17. Open source posturography.

    Science.gov (United States)

    Rey-Martinez, Jorge; Pérez-Fernández, Nicolás

    2016-12-01

    The proposed validation goal of 0.9 in intra-class correlation coefficient was reached with the results of this study. With the obtained results we consider that the developed software (RombergLab) is a validated balance assessment software. The reliability of this software is dependent of the used force platform technical specifications. Develop and validate a posturography software and share its source code in open source terms. Prospective non-randomized validation study: 20 consecutive adults underwent two balance assessment tests, six condition posturography was performed using a clinical approved software and force platform and the same conditions were measured using the new developed open source software using a low cost force platform. Intra-class correlation index of the sway area obtained from the center of pressure variations in both devices for the six conditions was the main variable used for validation. Excellent concordance between RombergLab and clinical approved force platform was obtained (intra-class correlation coefficient =0.94). A Bland and Altman graphic concordance plot was also obtained. The source code used to develop RombergLab was published in open source terms.

  18. Open-Access Publishing

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2013-06-01

    Full Text Available Nature, one of the most prominent scientific journals dedicated one of its issues to recent changes in scientific publishing (Vol. 495, Issue 7442, 27 March 2013. Its editors stressed that words technology and revolution are closely related when it comes to scientific publishing. In addition, the transformation of research publishing is not as much a revolution than an attrition war in which all sides are buried. The most important change they refer to is the open-access model in which an author or an institution pays in advance for publishing a paper in a journal, and the paper is then available to users on the Internet free of charge.According to preliminary results of a survey conducted among 23 000 scientists by the publisher of Nature, 45% of them believes all papers should be published in open access, but at the same time 22% of them would not allow the use of papers for commercial purposes. Attitudes toward open access vary according to scientific disciplines, leading the editors to conclude the revolution still does not suit everyone.

  19. ADOPT Open Access

    CERN Multimedia

    2007-01-01

    Are you writing a theoretical paper? An experimental one? Or one about instrumentation? You can publish it in Open Access. Now. Read how... You might have heard about Open Access, the next big thing in scientific publishing. The idea is to make the results of your (publicly funded) research free to read for everyone out there ... not only those lucky ones who work in places where libraries can afford to purchase the expensive subscriptions to scientific journals. CERN, DESY and other particle physics institutes have accepted an offer by one of the leading journals in High Energy Physics, JHEP: our libraries will pay a special subscription fee, and, in exchange, all articles with at least one author from our institutes will be published in Open Access. Anyone, anywhere and anytime will be able to read them, without any financial barrier! If you are writing an instrumentation paper, you can submit it to JINST and benefit from the same offer. This is a major step forward in the planned conversion of existi...

  20. Development of a methodology for the evaluation of energy efficiency of central irrigation pivots; Desenvolvimento de uma metodologia para a avaliacao da eficiencia energetica de pivos centrais de irrigacao

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Aureo Cezar de [Centro Federal de Educacao Tecnologica de Petrolina (CEFET-Pet), PE (Brazil); Guimaraes Junior, Sebastiao Camargo; Camacho, Jose Roberto; Salerno, Carlos Henrique [Universidade Federal de Uberlandia (NERFAE/UFU), MG (Brazil). Fac. de Engenharia Eletrica. Nucleo de Eletricidade Rural e Fontes Alternativas de Energia

    2006-07-01

    It will be presented in this work a methodology for the evaluation of the energy efficiency of irrigation center systems by central pivot. Integrating water efficiency application with the energy associated to the sprinklers, adduction pipeline, pivot arm and pump systems, the proposed indexes make possible to evaluate the energy income of each component of the irrigation system, contributing for the increase of the global efficiency of the irrigated agriculture. (author)

  1. Bispectrum from open inflation

    Energy Technology Data Exchange (ETDEWEB)

    Sugimura, Kazuyuki [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto (Japan); Komatsu, Eiichiro, E-mail: sugimura@yukawa.kyoto-u.ac.jp, E-mail: komatsu@mpa-garching.mpg.de [Max-Planck-Institut für Astrophysik, Karl-Schwarzschild Str. 1, 85741 Garching (Germany)

    2013-11-01

    We calculate the bispectrum of primordial curvature perturbations, ζ, generated during ''open inflation.'' Inflation occurs inside a bubble nucleated via quantum tunneling from the background false vacuum state. Our universe lives inside the bubble, which can be described as a Friedmann-Lemaȋtre-Robertson-Walker (FLRW) universe with negative spatial curvature, undergoing slow-roll inflation. We pay special attention to the issue of an initial state for quantum fluctuations. A ''vacuum state'' defined by a positive-frequency mode in de Sitter space charted by open coordinates is different from the Euclidean vacuum (which is equivalent to the so-called ''Bunch-Davies vacuum'' defined by a positive-frequency mode in de Sitter space charted by flat coordinates). Quantum tunneling (bubble nucleation) then modifies the initial state away from the original Euclidean vacuum. While most of the previous study on modifications of the initial quantum state introduces, by hand, an initial time at which the quantum state is modified as well as the form of the modification, an effective initial time naturally emerges and the form is fixed by quantum tunneling in open inflation models. Therefore, open inflation enables a self-consistent computation of the effect of a modified initial state on the bispectrum. We find a term which goes as (ζ{sub k{sub 1}}ζ{sub k{sub 2}}ζ{sub k{sub 3}})∝1/k{sub 1}{sup 2}k{sub 3}{sup 4} in the so-called squeezed configurations, k{sub 3} << k{sub 1} ≈ k{sub 2}, in agreement with the previous study on modifications of the initial state. The bispectrum in the exact folded limit, e.g., k{sub 1} = k{sub 2}+k{sub 3}, is also enhanced and remains finite. However, these terms are exponentially suppressed when the wavelength of ζ is smaller than the curvature radius of the universe. The leading-order bispectrum is equal to the usual one from single-field slow-roll inflation; the terms

  2. A New Way of Measuring Openness: The Open Governance Index

    Directory of Open Access Journals (Sweden)

    Liz Laffan

    2012-01-01

    Full Text Available Open source software is now "business as usual" in the mobile industry. While much attention is given to the importance of open source licenses, we argue in this article that the governance model can be as necessary to a project’s success and that projects vary widely in the governance models – whether open or closed – that they employ. Open source governance models describe the control points that are used to influence open source projects with regard to access to the source code, how the source code is developed, how derivatives are created, and the community structure of the project. Governance determines who has control over the project beyond what is deemed legally necessary via the open source licenses for that project. The purpose of our research is to define and measure the governance of open source projects, in other words, the extent to which decision-making in an open source project is "open" or "closed". We analyzed eight open source projects using 13 specific governance criteria across four areas of governance: access, development, derivatives and community. Our findings suggest that the most open platforms will be most successful in the long term, however we acknowledge exceptions to this rule. We also identify best practices that are common across these open source projects with regard to source code access, development of source code, management of derivatives, and community structure. These best practices increase the likelihood of developer use of and involvement in open source projects.

  3. EVALUATION OF RAPTOR (IMAZAMOX AND PIVOT (IMAZETAPHYR HERBICIDES EFFICIENCY AND SELECTIVITY ON WEED CONTROL IN THE SOYBEAN CROP AVALIAÇÃO DA EFICIÊNCIA E SELETIVIDADE DOS HERBICIDAS RAPTOR (IMAZOMOX E PIVOT (IMAZETHAPYR NA CULTURA DA SOJA (Glycine Max (L. Merrill

    Directory of Open Access Journals (Sweden)

    Edward Madureira Brasil

    2007-09-01

    Full Text Available

    This experiment was carried out at Escola de Agromia - Universidade Federal de Goiás, Goiás State, with the purpose of evaluating efficiency and selectivity of Raptor (Imazamox and Pivot (Imazetapyr on weed control in the soybean crop. Seven treatments were tested: 1-Raptor DG + Cicol (42g ai/ha; Raptor DG + Cicol (49g ai/ha; Pivot DG + Cicol (80g ai/ha; Pivot DG + Cicol (98g ai/ha, Pivot AS (100g ai/ha; Flex + Energic (250g ai/ha + 0.2% not weeded control. These treatments were planted as randomized blocks design with four replications. The soybean cultivar was Emgopa 313 sowing in 50 cm spacing and 20 plants/m density. At third evaluation, the treatments controlled more than 90% of Sida rhombifolia L., Blainvillea rhomboidea Cass., Spermacoce latifolia Aubl., Commelina nudiflora L. and Ipomoea purpurea Lam.

    KEY-WORDS: Imazamox; imazetaphyr; soybean; weed.

    Com o objetivo de avaliar a eficiência e a seletividade dos produtos Raptor (Imazamox e Pivot (Imazethapyr no controle de plantas daninhas na cultura da soja, instalou-se um experimento na Escola de Agronomia da Universidade Federal de Goiás, no município de Goiânia - GO. O experimento constituiu-se de sete tratamentos: Raptor DG + Cicol (42 g ia/ha; Raptor DG + Cicol (49 g ia/ha; Pivot DG + Cicol (80 g ia/ha; Pivot DG + Cicol (98 g ia/ha; Pivot AS (100 g ia/ha; Flex + Energic (250 g ia/ha + 0,2% e testemunha. O delineamento foi o de blocos ao acaso com quatro repetições e o cultivar de soja utilizado foi o Emgopa 313, com espaçamento de 50 cm e com densidade de 20 plantas/m. Observou-se que os tratamentos na terceira época de avaliação controlaram em mais de 90% as plantas daninhas guanxuma (Sida

  4. Web GIS in practice IX: a demonstration of geospatial visual analytics using Microsoft Live Labs Pivot technology and WHO mortality data

    Directory of Open Access Journals (Sweden)

    Ra Nagisetty Venkateswara

    2011-03-01

    Full Text Available Abstract The goal of visual analytics is to facilitate the discourse between the user and the data by providing dynamic displays and versatile visual interaction opportunities with the data that can support analytical reasoning and the exploration of data from multiple user-customisable aspects. This paper introduces geospatial visual analytics, a specialised subtype of visual analytics, and provides pointers to a number of learning resources about the subject, as well as some examples of human health, surveillance, emergency management and epidemiology-related geospatial visual analytics applications and examples of free software tools that readers can experiment with, such as Google Public Data Explorer. The authors also present a practical demonstration of geospatial visual analytics using partial data for 35 countries from a publicly available World Health Organization (WHO mortality dataset and Microsoft Live Labs Pivot technology, a free, general purpose visual analytics tool that offers a fresh way to visually browse and arrange massive amounts of data and images online and also supports geographic and temporal classifications of datasets featuring geospatial and temporal components. Interested readers can download a Zip archive (included with the manuscript as an additional file containing all files, modules and library functions used to deploy the WHO mortality data Pivot collection described in this paper.

  5. Contribution of the pivot nurse in oncology to the experience of receiving a diagnosis of cancer by the patient and their loved ones.

    Science.gov (United States)

    Leboeuf, Irène; Lachapelle, Dominique; Dubois, Sylvie; Genest, Catherine

    2014-01-01

    The announcement of a cancer diagnosis represents a difficult situation for the patient, their loved ones and professionals (Reich, Vennin & Belkacémie, 2008). Until now, few studies have described nurses' contribution to this critical moment along the care trajectory (Tobin, 2012) and even fewer, the contribution of the pivot nurse in oncology (OPN) or infirmière pivot en oncologie (PNO) as this specialist is called in Quebec. This study aims to document the OPN's contribution to the cancer experience of the patient and their loved ones, from the time the diagnosis is communicated to the period immediately following (four to six weeks). Fourteen PNOs from a Montreal university health centre took part in two individual interviews. Results show that PNOs offer personalized support which draws on their expertise to better understand the experience lived by patients and their loved ones, and adapt their interventions according to their needs and the timing of these interventions. These results support issuing three recommendations for nursing practice in the areas of PNOs; development of expertise, interprofessional collaboration and environment.

  6. Web GIS in practice IX: a demonstration of geospatial visual analytics using Microsoft Live Labs Pivot technology and WHO mortality data.

    Science.gov (United States)

    Kamel Boulos, Maged N; Viangteeravat, Teeradache; Anyanwu, Matthew N; Ra Nagisetty, Venkateswara; Kuscu, Emin

    2011-03-16

    The goal of visual analytics is to facilitate the discourse between the user and the data by providing dynamic displays and versatile visual interaction opportunities with the data that can support analytical reasoning and the exploration of data from multiple user-customisable aspects. This paper introduces geospatial visual analytics, a specialised subtype of visual analytics, and provides pointers to a number of learning resources about the subject, as well as some examples of human health, surveillance, emergency management and epidemiology-related geospatial visual analytics applications and examples of free software tools that readers can experiment with, such as Google Public Data Explorer. The authors also present a practical demonstration of geospatial visual analytics using partial data for 35 countries from a publicly available World Health Organization (WHO) mortality dataset and Microsoft Live Labs Pivot technology, a free, general purpose visual analytics tool that offers a fresh way to visually browse and arrange massive amounts of data and images online and also supports geographic and temporal classifications of datasets featuring geospatial and temporal components. Interested readers can download a Zip archive (included with the manuscript as an additional file) containing all files, modules and library functions used to deploy the WHO mortality data Pivot collection described in this paper.

  7. Open Source Seismic Hazard Analysis Software Framework (OpenSHA)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — OpenSHA is an effort to develop object-oriented, web- & GUI-enabled, open-source, and freely available code for conducting Seismic Hazard Analyses (SHA). Our...

  8. Open-market innovation.

    Science.gov (United States)

    Rigby, Darrell; Zook, Chris

    2002-10-01

    Companies in many industries are feeling immense pressure to improve their ability to innovate. Even in these tough economic times, executives have pushed innovation initiatives to the top of their priority lists, but they know that the best ideas aren't always coming out of their own R&D labs. That's why a growing number of companies are exploring the idea of open-market innovation--an approach that uses tools such as licensing, joint ventures, and strategic alliances to bring the benefits of free trade to the flow of new ideas. For instance, when faced with the unanticipated anthrax scare last fall, Pitney Bowes had nothing in its R&D pipeline to help its customers combat the deadly spores. So it sought help from outside innovators to come up with scanning and imaging technologies that could alert its customers to tainted letters and packages. And Dow Chemical and Cargill jointly produced a new form of plastic derived from plant starches--a breakthrough product that neither company could have created on its own. In this article, Bain consultants Darrell Rigby and Chris Zook describe the advantages and disadvantages of open-market innovation and the ways some companies are using it to gain competitive advantage. By importing ideas from the outside, the authors say, companies can collect more and better ideas from different kinds of experts. Creative types within a company will stick around longer if they know their ideas will eventually find a home--as internal R&D projects or as concepts licensed to outside buyers. Exporting ideas also gives companies a way to measure an innovation's real value. However, the authors warn against entering into open-market innovation without properly structuring deals: Xerox and TRW virtually gave away their innovations and had to stand by while other companies capitalized on them.

  9. Open for business?

    DEFF Research Database (Denmark)

    Bogers, Marcel; Jensen, Jørgen Dejgård

    2017-01-01

    and some of its main components — considering an internal and external orientation — and how they can be applied to the gastronomic sector. On this basis, we propose, develop and test an empirical framework for the economic sustainability of gastronomic enterprises. Based on data from a publicly available...... the sector to create value through for example product differentiation, market segmentation, and so on. The analysis revealed 9 different clusters, which represent different business models in terms of customer value creation, segmentation and resource utilization — highlighting either more closed or open...

  10. Open innovation in networks

    DEFF Research Database (Denmark)

    Hu, Yimei

    Open innovation in networks has been a popular topic for long, this paper rethinks the concepts of innovation network and network organization, and clarifies the differences between them based on the network perspective. Network perspective means that: network is the context of firms; market...... and hierarchy can be analyzed from a network approach. Within a network perspective, there are different levels of network, and a firm may not always has the power to “manage” innovation networks due to different levels of power. Based on the strength of a firm’s power, its role may varies from manager...

  11. Open verification methodology cookbook

    CERN Document Server

    Glasser, Mark

    2009-01-01

    Functional verification is an art as much as a science. It requires not only creativity and cunning, but also a clear methodology to approach the problem. The Open Verification Methodology (OVM) is a leading-edge methodology for verifying designs at multiple levels of abstraction. It brings together ideas from electrical, systems, and software engineering to provide a complete methodology for verifying large scale System-on-Chip (SoC) designs. OVM defines an approach for developing testbench architectures so they are modular, configurable, and reusable. This book is designed to help both novic

  12. OpenLabNotes

    DEFF Research Database (Denmark)

    List, Markus; Franz, Michael; Tan, Qihua

    2015-01-01

    the longevity of the providers. Turning towards free alternatives, however, raises questions about data protection, which are not sufficiently addressed by available solutions. To serve as legal documents, ELNs must prevent scientific fraud through technical means such as digital signatures. It would also......LabFramework, a powerful and flexible laboratory information management system. In contrast to comparable solutions, it allows to protect the intellectual property of its users by offering data protection with digital signatures. OpenLabNotes effectively Closes the gap between research documentation and sample management...

  13. Why Open Access?

    OpenAIRE

    2015-01-01

    As mentioned in the previous editorial (López-López, 2015), Suber’s (2015) book is a significant contribution that we can use to clarify the limits and the scope of Open Access (OA), and it is also helpful in explaining confusions and inaccuracies that are widespread in our communities, which are not quite ready to face the accelerated changes that are being generated by the new dynamics of scientific output and communication (Gallegos, Berra, Benito, & López-López, 2014). Suber (2015) st...

  14. Open Source Software Acquisition

    DEFF Research Database (Denmark)

    Holck, Jesper; Kühn Pedersen, Mogens; Holm Larsen, Michael

    2005-01-01

    Lately we have seen a growing interest from both public and private organisations to adopt OpenSource Software (OSS), not only for a few, specific applications but also on a more general levelthroughout the organisation. As a consequence, the organisations' decisions on adoption of OSS arebecoming......, in smaller organisations and in small-scale adoption of OSS, the cheapprice of OSS is a major enabler, as it provides a good opportunity for experiments and short-termeconomic benefits. For small organisations these experiments can lead to development of a commonIT-architecture, and in larger organisations...

  15. Supersymmetric Open Wilson Lines

    CERN Document Server

    Baker, Edward B

    2011-01-01

    In this paper we study Open Wilson Lines (OWL's) in the context of two Supersymmetric Yang Mills theories. First we consider four dimensional N=2 Supersymmetric Yang Mills Theory with hypermultiplets transforming in the fundamental representation of the gauge group, and find supersymmetric OWL's only in the superconformal versions of these theories. We then consider four dimensional N=4 SYM coupled to a three dimensional defect hypermultiplet. Here there is a semi-circular supersymmetric OWL, which is related to the ray by a conformal transformation. We perform a perturbative calculation of the operators in both theories, and discuss using localization to compute them non-perturbatively.

  16. ICALEPS 2005 : opening session

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    ICALEPCS 2005, the tenth International Conference on Accelerator and Large Experimental Physics Control Systems, will be held in Geneva, Switzerland, 10-14 Oct. 2005 at the International Conference Center Geneva (CICG). ICALEPCS 2005 thus falls in the year that UNESCO has declared the "World Year of Physics". ICALEPCS covers all aspects of control and operation of Experimental Physics facilities such as particle accelerators, particle detectors, optical telescopes, radio telescopes, nuclear fusion facilities like Tokamaks, nuclear reactors, lasers, etc .... Opening session by . A. Daneels (CERN): Introducting ICALEPCS 2005 . C.Lamprecht (Republic & State of Geneva): Welcome speech . J. Lister (EPFL): Welcome speech . J. Engelen (CERN): The machine and experiment challenges of LHC

  17. Innovation with open data: Essential elements of open data ecosystems

    NARCIS (Netherlands)

    Zuiderwijk, A.M.G.; Janssen, M.F.W.H.A.; Davis, C.B.

    2014-01-01

    Open data ecosystems are expected to bring many advantages, such as stimulating citizen participation and innovation. However, scant attention has been given to what constitutes an open data ecosystem. The objective of this paper is to provide an overview of essential elements of open data ecosystem

  18. Pivotal importance of STAT3 in protecting the heart from acute and chronic stress: new advancement and unresolved issues

    Directory of Open Access Journals (Sweden)

    Foaud A. Zouein

    2015-11-01

    Full Text Available The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3 has been implicated in protecting the heart from acute ischemic injury under both basal conditions and as a crucial component of pre- and post-conditioning protocols. A number of anti-oxidant and antiapoptotic genes are upregulated by STAT3 via canonical means involving phosphorylation on Y705 and S727, although other incompletely defined posttranslational modifications are involved. In addition, STAT3 is now known to be present in cardiac mitochondria and to exert actions that regulate the electron transport chain, reactive oxygen species (ROS production, and mitochondrial permeability transition pore (mPTP opening. These non-canonical actions of STAT3 are enhanced by S727 phosphorylation. The molecular basis for the mitochondrial actions of STAT3 are poorly understood, but STAT3 is known to interact with a critical subunit of complex I and to regulate complex I function. Dysfunctional complex I has been implicated in ischemic injury, heart failure, and the aging process. Evidence also indicates that STAT3 is protective to the heart under chronic stress conditions, including hypertension, pregnancy, and advanced age. Paradoxically, the accumulation of unphosphorylated STAT3 (U-STAT3 in the nucleus has been suggested to drive pathological cardiac hypertrophy and inflammation via noncanonical gene expression, perhaps involving a distinct acetylation profile. U-STAT3 may also regulate chromatin stability. Our understanding of how the noncanonical genomic and mitochondrial actions of STAT3 in the heart are regulated and coordinated with the canonical actions of STAT3 is rudimentary. Here we present an overview of what is currently known about the pleotropic actions of STAT3 in the heart in order to highlight controversies and unresolved issues.

  19. [Opening medicine containers].

    Science.gov (United States)

    Glerup, E; Dengsø, H

    1990-07-09

    In connection with self-administration of medicine for patients with rheumatoid arthritis, patients with weak hands and elderly patients in general, the design of many medicine containers makes them awkward to handle for the patients. In this investigation 12 different medicine containers were tested. The 12 containers represent the antirheumatic medicine containers available on the market in Denmark in 1988. Sixty patients participated in the investigation. Thirty had rheumatoid arthritis and 30 had normal hand function. The age range was 40-85 years The patients had the choice between five possible answers concerning each container. In all patients, grip strength was measured. The patients with rheumatoid arthritis were classified in four functional classes, and pulpa-vola distance end thumb--5th MCP point distance were measured. The opening mechanisms of 29% of the antirheumatic medicine containers are unacceptable; these are plastic containers with a "push-off" top and suppository packs. 46%--(containers with screw cap or pressure dispensing) are considered acceptable. For 25% (tablet and capsule blister packs) the patients' estimate varied. It is important that medicine containers can be opened by the patients without difficulty, so that they do not present a hindrance to a correct intake of medicine or result in an unnecessary admission to hospital. The results of this investigation show that it is of continuous importance to encourage the production of medicine containers that comply with the requirements of the patients.

  20. Challenges of open access

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, J.

    1994-09-01

    As utilities provide open access to their transmission grids under new federal regulations, the volume of bulk power transactions is expected to rise sharply - putting a strain on already heavily loaded delivery systems. Can everybody ride a grid that was designed to be operated in a simpler business environment New EPRI software and analysis methods can help utilities cope with the practical problems that open access brings, such as accurately calculating the costs of providing transmission services to third parties and operating power systems closer to their inherent technical limits. A variety of power system analysis programs are already available for planning purposes, and on-line versions for use by operations personnel are beginning to enter utility demonstration. In addition, new resource scheduling and generation control software can help utilities reduce the total cost of electricity production by up to 3%. A decision framework has also been prepared that a utility can use to integrate technical information about its power system with overall corporate strategy.

  1. Printshop open days

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    With new machines, new services and new opening hours, the CERN Printshop has turned over many new leaves at the start of 2013. Come and find out more from 25 to 27 March at the Printshop open days!   The CERN Printshop’s new 8-metre long black and white printer. The CERN Printshop’s new 8-metre long black-and-white printer is a technical marvel. It can produce 160 pages per minute (it prints on both sides in one pass) and can also staple, punch holes, do thermal binding and make A4 or A5 brochures. The new colour printer is more discreet but no less efficient: it churns out 70 A4 or A3 pages per minute. Once they are printed, colour documents can be inserted into the black and white machine to be hole-punched, made into brochures or bound. They can even be mixed in with black-and-white pages and, as if by magic, come out in the right order! Having recently acquired a state-of-the-art large-format printer, the CERN Printshop can now print posters in A2, A1 or A0 format. ...

  2. Open innovation and serious gaming

    NARCIS (Netherlands)

    Westera, Wim

    2010-01-01

    Westera, W. (2010, 15 April). Open innovation and serious gaming. Workshop presentation and discussion with Hogeschool Zuyd, Communication and Multimedia Design, Heerlen, The Netherlands: Open University of the Netherlands.

  3. Virtuelt skrivebord med open office

    DEFF Research Database (Denmark)

    Nielsen, Kurt Gammelgaard

    2009-01-01

    SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

  4. SOFTWARE OPEN SOURCE, SOFTWARE GRATIS?

    Directory of Open Access Journals (Sweden)

    Nur Aini Rakhmawati

    2006-01-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Berlakunya Undang – undang Hak Atas Kekayaan Intelektual (HAKI, memunculkan suatu alternatif baru untuk menggunakan software open source. Penggunaan software open source menyebar seiring dengan isu global pada Information Communication Technology (ICT saat ini. Beberapa organisasi dan perusahaan mulai menjadikan software open source sebagai pertimbangan. Banyak konsep mengenai software open source ini. Mulai dari software yang gratis sampai software tidak berlisensi. Tidak sepenuhnya isu software open source benar, untuk itu perlu dikenalkan konsep software open source mulai dari sejarah, lisensi dan bagaimana cara memilih lisensi, serta pertimbangan dalam memilih software open source yang ada. Kata kunci :Lisensi, Open Source, HAKI

  5. UN OPEN GIS CAPACITY BUILDING

    National Research Council Canada - National Science Library

    A. Albertella; M. A. Brovelli; D. Gonzalez Ferreiro

    2017-01-01

    The UN Open GIS Initiative is to identify and develop, under UN guidance, an Open Source GIS bundle that meets the requirements of UN operations, taking full advantage of the expertise of mission partners...

  6. Virtuelt skrivebord med open office

    DEFF Research Database (Denmark)

    Nielsen, Kurt Gammelgaard

    2009-01-01

    SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

  7. Eclipsing binaries in open clusters

    DEFF Research Database (Denmark)

    Southworth, John; Clausen, J.V.

    2006-01-01

    Stars: fundamental parameters - Stars : binaries : eclipsing - Stars: Binaries: spectroscopic - Open clusters and ass. : general Udgivelsesdato: 5 August......Stars: fundamental parameters - Stars : binaries : eclipsing - Stars: Binaries: spectroscopic - Open clusters and ass. : general Udgivelsesdato: 5 August...

  8. The open information systems journal

    National Research Council Canada - National Science Library

    2007-01-01

    The Open Information Systems Journal is an Open Access online journal which publishes research articles, reviews, and letters in all areas on the development, use, application and influence of information systems...

  9. Open innovation and serious gaming

    NARCIS (Netherlands)

    Westera, Wim

    2010-01-01

    Westera, W. (2010, 15 April). Open innovation and serious gaming. Workshop presentation and discussion with Hogeschool Zuyd, Communication and Multimedia Design, Heerlen, The Netherlands: Open University of the Netherlands.

  10. Abdominal aortic aneurysm repair - open

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007392.htm Abdominal aortic aneurysm repair - open To use the sharing features on this page, please enable JavaScript. Open abdominal aortic aneurysm repair is surgery to fix a widened part ...

  11. Open Educational Resources and Practices

    Science.gov (United States)

    Blackall, Leigh

    2008-01-01

    This article looks at what constitutes an open educational resource and considers the issues and benefits to an educational institution that is moving to participate in open educational resource development and to adopt more open educational practices. It describes the initial steps in these directions being made by the Educational Development…

  12. Open Culture Data position paper

    NARCIS (Netherlands)

    L.B. Baltussen (Lotte); M. Brinkerink (Maarten); N. Timmermans (Nikki); M. Zeinstra (Maarten)

    2013-01-01

    textabstractOpen Culture Data started as a grassroots movement at the end of 2011, with the aim to open up data in the cultural sector and stimulate (creative) reuse. In this context, we organised a hackathon, which resulted in the creation of 13 Open Culture Data apps. After this successful first h

  13. Open Education and Critical Pedagogy

    Science.gov (United States)

    Farrow, Robert

    2017-01-01

    This paper argues for a revaluation of the potential of open education to support more critical forms of pedagogy. Section 1 examines contemporary discourses around open education, offering a commentary on the perception of openness as both a disruptive force in education, and a potential solution to contemporary challenges. Section 2 examines the…

  14. OpenStack cloud security

    CERN Document Server

    Locati, Fabio Alessandro

    2015-01-01

    If you are an OpenStack administrator or developer, or wish to build solutions to protect your OpenStack environment, then this book is for you. Experience of Linux administration and familiarity with different OpenStack components is assumed.

  15. Desenvolvimento de um sistema de pulverização acoplável a pivô central Development of a spray system attached to center pivot

    Directory of Open Access Journals (Sweden)

    Luis A. A. Vilela

    2004-12-01

    Full Text Available Com o objetivo de se aplicar produtos químicos às culturas, desenvolveu-se um sistema de pulverização acoplável a pivô central e também um protótipo do equipamento. Durante a aplicação, a estrutura aérea do pivô central se desloca sem irrigar, apenas transportando o sistema de pulverização sobre a área. O sistema é composto de duas barras de pulverização instaladas em cada vão do pivô. O regime intermitente da pulverização, responsável pela redução da calda aplicada, foi feito por meio de um circuito eletrônico, sincronizado ao acionamento dos motorredutores, que aciona uma válvula solenóide localizada na entrada da barra de pulverização. O sistema desenvolvido possibilita aplicar-se volume de pulverização de até 246 L ha-1. Os diâmetros de gotas atenderam às recomendações técnicas para aplicação de defensivos agrícolas. Tempos ligado-desligado da válvula solenóide de 0,4 - 2,5, 0,5 - 2,5, 0,3 - 3,5 e 0,4 - 3,5 s resultaram em valores de coeficiente de variação inferiores a 15%, aceitáveis para pulverizações por meio terrestre.For the application of chemical products a equipment attached to center pivots was developed. During application, the aerial structure of the center pivot system moves, without accomplishing irrigation, just transporting the spray system around the area. In order to compensate different speeds two spray bars were installed in each pivot span. Intermittent spraying was achieved by means of solenoid valves controlled by electronic circuit synchronized with electric motor gears. The system is able to apply a minimum volume of 246 L ha-1. Drop diameters obtained were compatible with the requirements of application of chemical products. On/off time sequences of 0.4 - 2.5, 0.5 - 2.5, 0.3 - 3.5 and 0.4 - 3.5 s resulted in coefficients of variation under 15%, that are acceptable for ground based applications.

  16. Based on the Viewpoint of "Shaoyang as Pivot" to Analyze Xiaoyindan Tang and Xiaoyangdan Tang%基于“少阳为枢”图解小阴旦汤、小阳旦汤

    Institute of Scientific and Technical Information of China (English)

    梁永林; 李金田; 史光伟; 李应存; 韩琦; 贾斌

    2016-01-01

    小阴旦汤证是外感阳邪致“精化为气”太过,则少阳生气大过,少阳为枢功能偏向于助东方升气,使六经升的力量表现太过,总体上表现“天气下降”不及,则取芍药“酸收”以抑太阳之开(少阳升气),取黄芩“苦降”以助阳明之合(少阳天气),更取姜草枣正补脾胃“地气”,用药之性味补入下降的力量,矫正少阳为枢偏于升太过的病证;而小阳旦汤证是外感阴邪致“精化为气”受阻(不及),则少阳生气不及,少阳为枢功能难以使地气上升,使六经升的力量表现不及,总体上表现“地气上升”不及,则取桂枝“辛开”以助太阳之开(少阳升气),取赤芍“酸收”以助降南方火气和西方天气,再取姜草枣正补脾胃“地气”,用药之性味补入上升的力量,矫正少阳为枢偏于升不及的病证.至于赤白芍之活用,则根据二者对阴的力量赤泄白补,小阴旦汤用白芍助阴以增加降的力量,小阳旦汤改用赤芍药则恰为防止白芍助阴而更加阻碍“地气上升”,且能泻南方火气太过.%The symptom of Xiaoyindan Tang is exogenous pathogenic factors "into Yang Qi" is resort to too much rage.Shaoyang for the pivot function tends to help lifting the Eastern Qi,make six liters power perform a lot,which performed by the "weather down" less and then to take acid Shaoyao to suppress peony the sun open (Shaoyang lift Qi),take the bitter Huangqin to help the Yangming (Shaoyang weather).What' more,it takes Ginger,Jujube,Licorice to tonify spleen and stomach Qi.The character and taste of medicine produce the function of reinforcing and reducing,which decreased the power of correction of Shaoyang diseases tends to rise too.For the Xiaoyinyangdan Tang syndrome is exogenous pathogenic factors "into Qi"(less),then blocked Shaoyang lifting Qi as Shaoyang for the pivot function is difficult to make up to six liters of Qi,power as the performance,the overall performance of "Qi rising

  17. Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on

    Directory of Open Access Journals (Sweden)

    O'Boyle Noel M

    2011-10-01

    Full Text Available Abstract Background The Blue Obelisk movement was established in 2005 as a response to the lack of Open Data, Open Standards and Open Source (ODOSOS in chemistry. It aims to make it easier to carry out chemistry research by promoting interoperability between chemistry software, encouraging cooperation between Open Source developers, and developing community resources and Open Standards. Results This contribution looks back on the work carried out by the Blue Obelisk in the past 5 years and surveys progress and remaining challenges in the areas of Open Data, Open Standards, and Open Source in chemistry. Conclusions We show that the Blue Obelisk has been very successful in bringing together researchers and developers with common interests in ODOSOS, leading to development of many useful resources freely available to the chemistry community.

  18. Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on

    Science.gov (United States)

    2011-01-01

    Background The Blue Obelisk movement was established in 2005 as a response to the lack of Open Data, Open Standards and Open Source (ODOSOS) in chemistry. It aims to make it easier to carry out chemistry research by promoting interoperability between chemistry software, encouraging cooperation between Open Source developers, and developing community resources and Open Standards. Results This contribution looks back on the work carried out by the Blue Obelisk in the past 5 years and surveys progress and remaining challenges in the areas of Open Data, Open Standards, and Open Source in chemistry. Conclusions We show that the Blue Obelisk has been very successful in bringing together researchers and developers with common interests in ODOSOS, leading to development of many useful resources freely available to the chemistry community. PMID:21999342

  19. The open data imperative

    Directory of Open Access Journals (Sweden)

    Professor Geoffrey Boulton

    2014-07-01

    Full Text Available The information revolution of recent decades is a world historical event that is changing the lives of individuals, societies and economies and with major implications for science, research and learning. It offers profound opportunities to explore phenomena that were hitherto beyond our power to resolve, and at the same time is undermining the process whereby concurrent publication of scientific concept and evidence (data permitted scrutiny, replication and refutation and that has been the bedrock of scientific progress and of ‘self-correction’ since the inception of the first scientific journals in the 17th century. Open publication, release and sharing of data are vital habits that need to be redefined and redeveloped for the modern age by the research community if it is to exploit technological opportunities, maintain self-correction and maximize the contribution of research to human understanding and welfare.

  20. Comunicazione e Open Access

    Directory of Open Access Journals (Sweden)

    Orazio Maria Valastro

    2005-06-01

    Full Text Available Il potenziale editoriale della rivista, sebbene compia appena il suo terzo anno di attività, è considerevole: basti pensare che la scelta fondante una parte del progetto editoriale, la pubblicazione di testi integrali, accessibili liberamente e gratuitamente su formato html, ha permesso l’accrescersi costante della consultazione delle pagine web pubblicate su internet e del numero dei visitatori che hanno avuto accesso agli articoli diffusi per ogni numero trimestrale. Condividendo e promuovendo i principi dell’Open-Access, il libero accesso al patrimonio culturale e scientifico, partecipando ad una comunicazione scientifica che favorisca una democratizzazione della conoscenza, si è inoltre indotto un valore aggiunto allo strumento editoriale: la valorizzazione della produzione scientifica e degli stessi contributi degli autori, insieme all’ampia divulgazione dei contenuti, liberamente accessibili da qualsiasi luogo del mondo tramite una connessione ad internet.

  1. The Open Science Grid

    Energy Technology Data Exchange (ETDEWEB)

    Pordes, Ruth; /Fermilab; Kramer, Bill; Olson, Doug; / /LBL, Berkeley; Livny, Miron; Roy, Alain; /Wisconsin U., Madison; Avery, Paul; /Florida U.; Blackburn, Kent; /Caltech; Wenaus, Torre; /Brookhaven; Wurthwein, Frank; /UC, San Diego; Gardner, Rob; Wilde, Mike; /Chicago U. /Indiana U.

    2007-06-01

    The Open Science Grid (OSG) provides a distributed facility where the Consortium members provide guaranteed and opportunistic access to shared computing and storage resources. OSG provides support for and evolution of the infrastructure through activities that cover operations, security, software, troubleshooting, addition of new capabilities, and support for existing and engagement with new communities. The OSG SciDAC-2 project provides specific activities to manage and evolve the distributed infrastructure and support its use. The innovative aspects of the project are the maintenance and performance of a collaborative (shared & common) petascale national facility over tens of autonomous computing sites, for many hundreds of users, transferring terabytes of data a day, executing tens of thousands of jobs a day, and providing robust and usable resources for scientific groups of all types and sizes. More information can be found at the OSG web site: www.opensciencegrid.org.

  2. The Open Science Grid

    CERN Document Server

    Pordes, Ruth; Olson, Doug; Livny, Miron; Roy, Alain; Avery, Paul; Blackburn, Kent; Wenaus, Torre; Wuerthwein, Frank K.; Gardner, Rob; Wilde, Mike; Blatecky, Alan; McGee, John; Quick, Rob

    2007-01-01

    The Open Science Grid (OSG) provides a distributed facility where the Consortium members provide guaranteed and opportunistic access to shared computing and storage resources. OSG provides support for and evolution of the infrastructure through activities that cover operations, security, software, troubleshooting, addition of new capabilities, and support for existing and engagement with new communities. The OSG SciDAC-2 project provides specific activities to manage and evolve the distributed infrastructure and support it's use. The innovative aspects of the project are the maintenance and performance of a collaborative (shared & common) petascale national facility over tens of autonomous computing sites, for many hundreds of users, transferring terabytes of data a day, executing tens of thousands of jobs a day, and providing robust and usable resources for scientific groups of all types and sizes. More information can be found at the OSG web site: www.opensciencegrid.org.

  3. The open science grid

    Energy Technology Data Exchange (ETDEWEB)

    Pordes, Ruth [Fermi National Accelerator Laboratory (United States); Petravick, Don [Fermi National Accelerator Laboratory (United States); Kramer, Bill [Lawrence Berkeley National Laboratory (United States); Olson, Doug [Lawrence Berkeley National Laboratory (United States); Livny, Miron [University of Wisconsin, Madison (United States); Roy, Alain [University of Wisconsin, Madison (United States); Avery, Paul [University of Florida (United States); Blackburn, Kent [California Institute of Technology (United States); Wenaus, Torre [Brookhaven National Laboratory (United States); Wuerthwein, Frank [University of California, San Diego (United States); Foster, Ian [University of Chicago (United States); Gardner, Rob [University of Chicago (United States); Wilde, Mike [University of Chicago (United States); Blatecky, Alan [Renaissance Computing Institute (United States); McGee, John [Renaissance Computing Institute (United States); Quick, Rob [Indiana University (United States)

    2007-07-15

    The Open Science Grid (OSG) provides a distributed facility where the Consortium members provide guaranteed and opportunistic access to shared computing and storage resources. OSG provides support for and evolution of the infrastructure through activities that cover operations, security, software, troubleshooting, addition of new capabilities, and support for existing and engagement with new communities. The OSG SciDAC-2 project provides specific activities to manage and evolve the distributed infrastructure and support it's use. The innovative aspects of the project are the maintenance and performance of a collaborative (shared and common) petascale national facility over tens of autonomous computing sites, for many hundreds of users, transferring terabytes of data a day, executing tens of thousands of jobs a day, and providing robust and usable resources for scientific groups of all types and sizes. More information can be found at the OSG web site: www.opensciencegrid.org.

  4. OPEN about obesity

    DEFF Research Database (Denmark)

    Lissner, L; Troiano, R P; Midthune, D

    2007-01-01

    OBJECTIVE: Obesity-related under-reporting of usual dietary intake is one of the most persistent sources of bias in nutrition research. The aim of this paper is to characterize obese and non-obese individuals with respect to reporting errors observed with two common dietary instruments, using...... energy and protein recovery biomarkers as reference measures. POPULATION AND METHODS: This report employs data from the Observing Protein and Energy Nutrition (OPEN) study. Analyses are based on stratified samples of 211 (57 obese) men and 179 (50 obese) women who completed 24-h recalls (24HR), food...... frequency questionnaires (FFQ), doubly labelled water (DLW) and urinary nitrogen (UN) assessments. RESULTS: In obese and non-obese subgroups, FFQ yielded lower energy and protein intake estimates than 24HR, although biomarker-based information indicated under-reporting with both dietary instruments. Gender...

  5. CCI Open Data Portal

    Science.gov (United States)

    Clarke, H.; Pechorro, E.; Bennett, V.; Farquhar, C.; Blower, J.

    2016-08-01

    The European Space Agency's (ESA's) Climate Change Initiative (CCI) Programme, producing harmonised datasets from long term Earth Observation satellite data records for a number of Essential Climate Variables (ECV's), provides a solid basis for climate science and modelling, for specialist application development and ultimately for European and global policy making.The resulting Climate Data Records (CDRs) represent a major investment of science, funding and personal effort, therefore extended access to those products is a key element of programme success.ECV datasets are currently being distributed through individual ECV teams, and access procedures and interfaces vary. To compliment and unify the work of the individual teams and to maximise the visibility and uptake of ECV data in the climate data user community within and beyond the CCI, a new ESA CCI project has started, to create a central open data portal and metadata catalogue for the ESA CCI project.This paper highlights key features of the Portal to date.

  6. Muse's open body

    Directory of Open Access Journals (Sweden)

    George Luiz França

    2010-07-01

    Full Text Available This text discuss the concept and the implications of the muses’ image in Jean-Luc Nancy’s philosophy, based, specially, in Les muses, a book published by him in 1994. This book is a collection of essays and conferences written or pronounced in different moments, in which the philosopher tries to articulate his conceptions of world and community with a way to think about language differently from the traditional philosophy (having to deal with its limits and with the occidental rationality’s limits, without the possibility of abolish them. It’s a discussion about the return of an image in the contemporaneity (the muse’s image, and about the theory that Nancy develops about the multiplicity of the arts, the aesthetics, the body and the idea of opening.

  7. Open water bells

    Science.gov (United States)

    Paramati, Manjula; Tirumkudulu, Mahesh S.

    2016-03-01

    A smooth circular moving liquid sheet is formed by the head-on impingement of two equal laminar water jets. We subject such a liquid sheet to uniform laminar air flow from one side such that the direction of air velocity is perpendicular to the liquid sheet. The pressure of the moving air deforms the liquid sheet giving rise to an open water bell. The water bell is symmetric suggesting that the gas flow around the bell is also symmetric and that the gravitational force is negligible. We have captured the shape of the water bells for varying air flow rates and for varying Weber numbers, and compared the measurements with theoretical predictions obtained from a force balance involving liquid inertia, surface tension, and pressure difference across the sheet. The pressure exerted by the gas phase on the front and the rear surface of the deformed liquid sheet is obtained from known results of flow past flat circular discs. The predicted steady state shapes match well with the measurements at low Weber numbers but differences are observed at high Weber numbers, where the sheet flaps and is no longer smooth. Interestingly, the shape predicted by assuming a constant pressure difference equal to the stagnation pressure over the whole of the front face of the sheet and free stream value over the whole of the rear face yields nearly identical results suggesting that an open water bell is similar to a closed water bell in that, to a good approximation, the pressure on either sides of the water bell is homogeneous.

  8. Timed bisimulation and open maps

    DEFF Research Database (Denmark)

    Hune, Thomas; Nielsen, Mogens

    1998-01-01

    of timed bisimulation. Thus the abstract results from the theory of open maps apply, e.g. the existence of canonical models and characteristic logics. Here, we provide an alternative proof of decidability of bisimulation for finite timed transition systems in terms of open maps, and illustrate the use......Open maps have been used for defining bisimulations for a range of models, but none of these have modelled real-time. We define a category of timed transition systems, and use the general framework of open maps to obtain a notion of bisimulation. We show this to be equivalent to the standard notion...... of open maps in presenting bisimulations....

  9. Quantum metrology in open systems: dissipative Cramér-Rao bound.

    Science.gov (United States)

    Alipour, S; Mehboudi, M; Rezakhani, A T

    2014-03-28

    Estimation of parameters is a pivotal task throughout science and technology. The quantum Cramér-Rao bound provides a fundamental limit of precision allowed to be achieved under quantum theory. For closed quantum systems, it has been shown how the estimation precision depends on the underlying dynamics. Here, we propose a general formulation for metrology scenarios in open quantum systems, aiming to relate the precision more directly to properties of the underlying dynamics. This feature may be employed to enhance an estimation precision, e.g., by quantum control techniques. Specifically, we derive a Cramér-Rao bound for a fairly large class of open system dynamics, which is governed by a (time-dependent) dynamical semigroup map. We illustrate the utility of this scenario through three examples.

  10. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

    Science.gov (United States)

    2016-01-01

    The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to participate, and patents were not sought. One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change. A second subseries displayed high potency, including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by the community; new findings may be cumulatively added to the present work. PMID:27800551

  11. "The Open Library at AU" (Athabasca University): Supporting Open Access and Open Educational Resources

    Science.gov (United States)

    Elliott, Colin; Fabbro, Elaine

    2015-01-01

    To address challenges that learners, course creators, librarians and academics involved with OER and MOOCs are facing when looking for scholarly materials, Athabasca University Library has initiated the development of "the Open Library at AU." This open library is a full library website that provides easy access to open and free…

  12. New frontiers in open innovation

    CERN Document Server

    Vanhaverbeke, Wim; West, Joel

    2014-01-01

    Companies have to innovate to stay competitive, and they have to collaborate with other organizations to innovate effectively. Although the benefits of "open innovation" have been described in detail before, mechanisms underlying how companies can be successful "open innovators" have not be understood well. A growing community of innovation management researchers started to develop different frameworks to understand open innovation in a more systematic way. This book provides a thorough examination of research conducted to date on open innovation, as well as a comprehensive overview of what will be the most important, most promising and most relevant research topics in this area during the next decade. "Open Innovation: Researching a new paradigm" (OUP 2006) was the first initiative to bring open innovation closer to the academic community. Open innovation research has since then been growing in an exponential way and research has evolved in different and unexpected directions. As the research field is growin...

  13. Evaluation of the information and support services in the voluntary sector using a new P-C-P (pivotal-core-peripheral) attributes model.

    Science.gov (United States)

    Philip, G; Stewart, J

    2000-11-01

    This paper describes the development and use of a modified SERVQUAL research instrument for measuring the service quality of voluntary organizations from the perspective of their 'customers'. A series of focus group meetings were run with providers and users of the services to identify the appropriate dimensions of service quality. These were structured meetings led by the researchers addressing set questions in a group setting. The meeting enabled the identification of six different dimensions of service quality which neatly mapped on to the pivotal-core-peripheral (P-C-P attributes model [Philip and Hazlett, 1997]), which was developed after extensive research of existing models such as SERVQUAL. These dimensions were used to develop a questionnaire to assess service quality within the voluntary sector. The questionnaire was distributed to 2005 service users, representing eight voluntary organizations from across Northern Ireland. The research resulted in the development of a methodology and research instrument suitable for measuring service quality in the voluntary sector.

  14. Manejo da irrigação em pastagem irrigada por pivô-central Irrigated pasture: water management under center pivot irrigation

    Directory of Open Access Journals (Sweden)

    Alexandre C. Xavier

    2004-12-01

    Full Text Available A aplicação de lâminas de irrigação em pastagem irrigada sob pivô-central é, de maneira geral, realizada sem um critério técnico pertinente ao sistema, pois se deve considerar que para um mesmo período a pastagem se encontra em diferentes estádios de desenvolvimento em cada parcela, apresentando taxas de evapotranspiração diferenciadas dentro da área irrigada; todavia, usualmente se aplica uma única lâmina para toda a área. Neste trabalho foi desenvolvido um modelo para aplicação de lâminas de irrigação distinta para cada parcela do pivô o qual, de modo geral, considera: i a capacidade do pivô-central de aplicar lâminas distintas na área; ii o nível de desenvolvimento da cultura em cada parcela; iii o período de retorno do gado a determinada parcela (ciclo de pastejo; e iv o potencial de desenvolvimento da pastagem de certa região. Para modelar o coeficiente de cultura (Kc foram utilizadas duas metodologias, a primeira com taxa de variação do Kc constante com o número de dias em que a parcela está em descanso (k, e a segunda, com taxa de variação do Kc na forma senoidal com k. O modelo foi aplicado para pastagens hipotéticas nas regiões de Piracicaba e Pereira Barreto, para avaliação e, como resultado, observou-se que o modelo se mostrou sensível ao nível de desenvolvimento de cada parcela e às condições de variação do clima de cada região.The application of irrigation depths in irrigated pasture under center pivot machines, in a general way, is accomplished without a pertinent technical criterion, because it should be considered that for any time period, the pasture plots are at different development stages (rotary pasture, presenting different evapotranspiration rates inside the irrigated area. Furthermore, farmers usually apply a single irrigation depth for the whole area. In this study a model was developed for the application of different irrigation depths in each portion of the pivot (pizza

  15. The membrane-extrinsic domain of cytochrome b(558/566) from the archaeon Sulfolobus acidocaldarius performs pivoting movements with respect to the membrane surface.

    Science.gov (United States)

    Schoepp-Cothenet, B; Schütz, M; Baymann, F; Brugna, M; Nitschke, W; Myllykallio, H; Schmidt, C

    2001-01-05

    The orientation of the membrane-attached cytochrome b(558/566)-haem with respect to the membrane was determined by electron paramagnetic resonance spectroscopy on two-dimensionally ordered oxidised membrane fragments from Sulfolobus acidocaldarius. Unlike the other redox centres in the membrane, the cytochrome b(558/566)-haem was found to cover a range of orientations between 25 degrees and 90 degrees. The described results are reminiscent of those obtained on the Rieske cluster of bc complexes and indicate that the membrane-extrinsic domain of cytochrome b(558/566) can perform pivoting motion between two extreme positions. Such a conformational flexibility is likely to play a role in electron transfer with its redox partners.

  16. The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance.

    Science.gov (United States)

    Jäger, Gunilla; Nilsson, Kristina; Björk, Glenn R

    2013-01-01

    The main features of translation are similar in all organisms on this planet and one important feature of it is the way the ribosome maintain the reading frame. We have earlier characterized several bacterial mutants defective in tRNA maturation and found that some of them correct a +1 frameshift mutation; i.e. such mutants possess an error in reading frame maintenance. Based on the analysis of the frameshifting phenotype of such mutants we proposed a pivotal role of the ribosomal grip of the peptidyl-tRNA to maintain the correct reading frame. To test the model in an unbiased way we first isolated many (467) independent mutants able to correct a +1 frameshift mutation and thereafter tested whether or not their frameshifting phenotypes were consistent with the model. These 467+1 frameshift suppressor mutants had alterations in 16 different loci of which 15 induced a defective tRNA by hypo- or hypermodifications or altering its primary sequence. All these alterations of tRNAs induce a frameshift error in the P-site to correct a +1 frameshift mutation consistent with the proposed model. Modifications next to and 3' of the anticodon (position 37), like 1-methylguanosine, are important for proper reading frame maintenance due to their interactions with components of the ribosomal P-site. Interestingly, two mutants had a defect in a locus (rpsI), which encodes ribosomal protein S9. The C-terminal of this protein contacts position 32-34 of the peptidyl-tRNA and is thus part of the P-site environment. The two rpsI mutants had a C-terminal truncated ribosomal protein S9 that destroys its interaction with the peptidyl-tRNA resulting in +1 shift in the reading frame. The isolation and characterization of the S9 mutants gave strong support of our model that the ribosomal grip of the peptidyl-tRNA is pivotal for the reading frame maintenance.

  17. An open question.

    Science.gov (United States)

    Ayling, John

    2004-01-01

    The lungs are surrounded by the pleural membranes. The visceral pleura directly covers the lung and is separated from the parietal pleura by a layer of surfactant, which reduces friction during respiratory movement. A potential space exists between these two layers, and they may become separated by fluid or air. A lung can collapse to the size of a fist under pressure from either. Standard treatment in the field for an open chest wound is an occlusive dressing. The first thing that can be used to occlude the wound is a gloved hand. After placing the dressing, evaluate the breath sounds and determine if they have improved. The dressing should be taped down on three sides, leaving one side open to relieve the pressure during exhalation (one-way valve). "Burping" the dressing involves lifting one side to make sure any pressure buildup is relieved, as occasionally the dressing can become adhered to the skin, which may lead to a tension pneumothorax. If, after ensuring the occlusive dressing is properly in place, the respiratory rate increases, distress level worsens, oxygen saturations fall and breath sounds decrease, then needle decompression is required. A neurovascular bundle is located underneath each rib, and it is important to avoid damage to that bundle by performing a decompression over the top of a rib. If the patient is intubated before the development of a tension pneumothorax, carefully evaluate the breath sounds (especially if the left-side sounds are diminished) to determine if the ET tube needs to be withdrawn a centimeter. The rescuer performing ventilation will usually recognize a tension pneumothorax by the difficulty in bagging the patient. Remember, when you perform a needle thoracentesis, you are creating an open chest wound. Early signs and symptoms of a tension pneumothorax include diminished or absent breath sounds, severe dyspnea, narrowing pulse pressure, tachycardia and restlessness. Neck veins may be distended, but this can be a normal

  18. Necobelac supporting open access, a path to open science

    OpenAIRE

    Agudelo-Calderon, Carlos Alberto

    2012-01-01

    On the occasion of the International Open Access week, a global event now in its 5th year, promoting Open Access (OA) as a new norm in scholarship and research, we, the NECOBELAC (Network of collaboration between Europe and Latin American Caribbean (LAC) countries to spread know-how in scientific writing and provide the best tools to exploit open access information for the safeguard of public health) project partners, wish to stimulate the scientific community to take action and make their wo...

  19. On the impact of being open

    NARCIS (Netherlands)

    Schuwer, Robert; van Genuchten, Michiel; Hatton, Les

    2015-01-01

    There's much discussion about being open, with topics such as open source software, open innovation, open research, and open education. Will the whole world be open, and, if so, what was all closed in the past? The authors analyze the similarities and differences between the open movements they've b

  20. The Open Library at AU (Athabasca University: Supporting Open Access and Open Educational Resources

    Directory of Open Access Journals (Sweden)

    Colin Elliott

    2015-04-01

    Full Text Available To address challenges that learners, course creators, librarians and academics involved with OER and MOOCs are facing when looking for scholarly materials, Athabasca University Library has initiated the development of the Open Library at AU. This open library is a full library website that provides easy access to open and free resources. Tools and information literacy tutorials are also included to enable learners, researchers, and others to find, evaluate, and use the information they need for their open learning course or research. Many of the challenges that those involved in open learning face are addressed by the open library and the potential impact it can have on open learning and knowledge sharing is tremendous. http://dx.doi.org/10.5944/openpraxis.7.2.196

  1. Implementing Open Data: The Open Data Commons Project

    Directory of Open Access Journals (Sweden)

    Jordan Hatcher

    2008-02-01

    Full Text Available Free and libre/open source software (F/LOSS movements have spawned similar solutions in many other contexts, each at differing stages of development. As F/LOSS enters the routine and familiarity of middle age, the open content movement--open source for non-software copyright and best embodied by the work of Creative Commons--has just graduated university and is getting a feel for the world. Even younger is the open data movement, whose legal tools have just started to come online.

  2. Opening Channels of Communication

    Directory of Open Access Journals (Sweden)

    Clarice Moura Costa

    2009-03-01

    Full Text Available Psychosis, as described through a psychodynamic perspective, is conceptualized as an attempt to deny the enveloping reality to avoid contact with the other. Music therapy is a way to break this barrier of non-communication raised by the patients. The music therapy process is configured as a trinomial – action (making music/ relationship (action with the other/communication (musical or verbal voluntary expression of feelings and conflicts, which, although intrinsically connected, is perceived in a sequential process. Aulagnier asserts that psychic activity represents the conjunction of three modes of functioning: the original process, the primary process and the secondary process. The perception of sound passes through three phases, corresponding to each manner of functioning of the psychic system – the pleasure of hearing, the desire to listen (to the other and the imperative of meaning. The music therapy process offers a significant similarity with the theory proposed by Aulagnier. We propose the hypothesis that in music therapy, there is an opportunity to (reexperience very archaic phases in the constitution of the ego, but in a new manner, so helping to open communication channels. This theoretical hypothesis is illustrated by real examples of patients.

  3. Defining Open Source

    Directory of Open Access Journals (Sweden)

    Russ Nelson

    2007-09-01

    Full Text Available The Open Source Initiative and the Free Software Foundation share a common goal: that everyone should be free to modify and redistribute the software they commonly use. 'Should' is of course a normative word. For the FSF, 'should' is a moral imperative. Anything else is an immoral restriction on people's activities, just as are restrictions on speech, press, movement, and religion. For the OSI, freedom is a necessary precondition for a world where "software doesn't suck", in the words of a founder of the OSI. The FSF started from its founder's GNU Manifesto widely published in 1985. Given the manifesto's hostility to copyright, and given the failure of the Free Software Foundation to gain any traction amongst commercial users of software even with a 13-year head start, a group of people gathered together in 1998 to talk about a new strategy to get the corporate world to listen to hackers. They were impressed by Eric Raymond's Cathedral and the Bazaar's take-up among business leaders.

  4. China opens the door

    Energy Technology Data Exchange (ETDEWEB)

    Starke, K.

    1997-01-01

    The door to China`s vast market for power generation was opened a bit further for foreign firms in November. That is when power ministry head Shi Dazhen said the country would rely on overseas investors for 20 percent of the funding needed to boost output--double the amount foreigners were previously allowed to contribute. Through 1995, foreigners invested $12.2 billion in China`s electricity industry, accounting for 10 percent of total investment. According to Shi, foreign investors will be asked to provide about $17 billion of the $84 billion China plans to invest in the sector over the next five years. Under China`s Ninth Five-Year Plan (1996-2000), the government aims to boost the country`s power generation capacity at the rate of 15,000 MW to 20,000 MW annually by the year 2000. Since China`s public external debt balance already exceeds $80 billion, however, the government would seem to have little choice but to allow foreigners a greater role. Shi also said that foreigners would be allowed 100 percent ownership of PRC power projects. This is discouraged under China`s current industry guidelines. It is, however, expected to be permitted under China`s first build-operate-transfer (BOT) law, which was anticipated by the end of 1996, says Susan Urkevich, director of project finance at HSBC Investment Bank Asia in Hong Kong. Indeed, China`s first BOT is already happening.

  5. Open Mushrooms: Stickiness revisited

    CERN Document Server

    Dettmann, Carl P

    2010-01-01

    We investigate mushroom billiards, a class of dynamical systems with sharply divided phase space. For typical values of the control parameter of the system $\\rho$, an infinite number of marginally unstable periodic orbits (MUPOs) exist making the system sticky in the sense that unstable orbits approach regular regions in phase space and thus exhibit regular behaviour for long periods of time. The problem of finding these MUPOs is expressed as the well known problem of finding optimal rational approximations of a real number, subject to some system-specific constraints. By introducing a generalized mushroom and using properties of continued fractions, we describe a zero measure set of control parameter values $\\rho\\in(0,1)$ for which all MUPOs are destroyed and therefore the system is less sticky. The open mushroom (billiard with a hole) is then considered in order to quantify the stickiness exhibited and exact leading order expressions for the algebraic decay of the survival probability function $P(t)$ are ca...

  6. Monographs and Open Access

    Directory of Open Access Journals (Sweden)

    Geoffrey Crossick

    2016-03-01

    Full Text Available This article presents the project that I led for HEFCE on the implications of OA (open access for monographs and other long-form research publications. The likely requirement that books should be OA if submitted to the REF (Research Excellence Framework after next means that OA development must be based on an understanding of the importance of the monograph in the AHSS (arts, humanities and social sciences as well as the challenges involved in making the transition to online OA. The project focused on three issues and each is summarized in turn in the article: What is the place of the monograph and other long-form publications in AHSS disciplines that makes it so important? What is happening to the monograph and is there a crisis as some suggest? What are the issues involved in moving monographs into a digital and OA environment – not just the challenge of effective business models but also many other aspects of sustaining and enhancing the qualities of the monograph? These include third-party rights, technical challenges, licences and the need for international collaboration.

  7. Experience in open markets

    Energy Technology Data Exchange (ETDEWEB)

    Bachman, G.; Way, R.; O`Donnell, J.

    1997-05-01

    The topic of discussion in this session was experience in open markets. The session was led by Guido Bachman, President of the Independent Power Producers` Society of Alberta (IPPSA), assisted by panel members Richard Way, Director of Energy Risk Management at TransAlta, John O`Donnell, Professor of Finance at Michigan State University, and Kelly Lail, Manager of Power Acquisition at B.C. Hydro. Way spoke of the experiences with market restructuring in Alberta, describing the consultative and legislative process which determined the structure of the Alberta Power Pool (APP). The Pool began operations in January 1996. Currently there are 33 participants from generators, to distributors and marketers. Supply and demand are managed by APP by setting an hourly price based on offers and bids. Both generators and distributors get the hourly pool price, so the input price and export price of the pool are the same, however, generators and distributors are free to enter into `contract for difference` agreements. O`Donnell discussed the status of competition in Michigan. He stressed the importance of Ontario to the Michigan market, echoing the conviction of U.S. regulators that a freer economy works better. Kelly Lail spoke of the unbundling of B.C. Hydro into several generating, transmission and distribution companies in preparation for moving from exclusive service to exclusive wholesale competition. He predicted that the fierce competition will lead to a an industry shakeout, leaving only one big (B.C. Hydro) and a few niche players.

  8. Editorial: Open Source in Government

    Directory of Open Access Journals (Sweden)

    Dru Lavigne

    2009-04-01

    Full Text Available Last summer, the Center for Strategic and International Studies published the sixth update to their Open Source Policy survey. The survey "tracks governmental policies on the use of open source software as reported in the press or other media." The report lists 275 open source policy initiatives. It also breaks down by country and by government level whether the policy on the use of open source is considered to be advisory, preferential, or mandatory. The editorial theme for the May issue of the OSBR is "open source in government" and we are pleased that the authors have drawn upon their experiences to provide insight into public policy regarding open source for many parts of the world.

  9. New Lifecycle for Firewall Openings

    CERN Multimedia

    Computer Security Team

    2011-01-01

    The first line in defending CERN against malicious traffic from the Internet is CERN's outer perimeter firewall. Following a well-defined set of rules, this firewall permits or denies any incoming network traffic to communicate with CERN hosts and controls outgoing traffic towards the Internet. System administrators can usually request firewall openings for the servers they are responsible for by using the LANDB Web interface (http://network.cern.ch). These requests are approved or rejected following the result of a subsequent security scan performed by the Computer Security Team. In the past, the number of firewall openings has grown significantly. System administrators naturally care more about their openings than about demanding closure once an opening has become obsolete or the server has changed purpose. Even worse, servers might pass under a new responsibility, i.e. a new system administrator, who does not even know about the current firewall openings. Indeed, a manual review of all firewall openings h...

  10. Improving Design with Open Innovation

    DEFF Research Database (Denmark)

    Christiansen, John K.; Gasparin, Marta; Varnes, Claus

    2013-01-01

    of the best practices for open innovation. However, projects were not equally successful. The outcome seems to be highly influenced by the type of collaborative arrangements used and their application. In particular, the analysis indicates that organizational factors seem to be indicative but not sufficient...... in open innovation need both a broad knowledge of the various potential elements of an open innovation effort and a flexible attitude toward their application. INSET: Summary of Projects....

  11. Active Control of Open Cavities

    Science.gov (United States)

    UKeiley, Lawrence

    2010-01-01

    Open loop edge blowing was demonstrated as an effective method for reducing the broad band and tonal components of the fluctuating surface pressure in open cavities. Closed loop has been successfully applied to low Mach number open cavities. Need to push actuators that are viable for closed loop control in bandwidth and output. Need a better understanding of the effects of control on the flow through detailed measurements so better actuation strategies can be developed.

  12. Magnetically insulated opening switch research

    Science.gov (United States)

    McGeoch, M. W.; Kraft, R.

    1987-01-01

    We examine the feasibility of an opening switch concept based on magnetic insulation in a coaxial thermionic diode. It is found that the impedance ratio between closed and open states of the diode is marginal for efficient energy transfer via this type of switch. The open, or insulated state of the diode is characterized by current leakage across the magnetic field which is associated with the presence of plasma waves.

  13. Open Scholarship and Research Universities

    OpenAIRE

    2005-01-01

    Compare the cost per article for publication in commercial journals, not-profit journals, and open-access journals. For universities that support open-archives and open-access journal management software as part of standard university infrastructure, the financial cost of hosting an additional journal is quite low. Scholars who commit to editing and promoting a journal need to focus primarily on the intellectual tasks with little concern for finances.

  14. Handbook of Open Source Tools

    CERN Document Server

    Koranne, Sandeep

    2011-01-01

    Handbook of Open Source Tools introduces a comprehensive collection of advanced open source tools useful in developing software applications. The book contains information on more than 200 open-source tools which include software construction utilities for compilers, virtual-machines, database, graphics, high-performance computing, OpenGL, geometry, algebra, graph theory , GUIs and more. Special highlights for software construction utilities and application libraries are included. Each tool is covered in the context of a real like application development setting. This unique handbook presents

  15. Partner Selection for Open Innovation

    Directory of Open Access Journals (Sweden)

    Marina Z. Solesvik

    2013-04-01

    Full Text Available In this article, we consider open innovation from the perspectives of: i causation and effectuation, and ii social networking. Our empirical evidence consists of a case study of a late-stage open-innovation project aimed at creating a hybrid ship that uses liquid natural gas and hydrogen as power sources. The results show that the effectuation approach is preferable to open innovation when the initiator of open innovation aims to keep sensitive information inside the closed group, when the initiator has established an effective team of representatives from other firms from earlier innovation projects, and when the participants are geographically close.

  16. Open Geoscience Database

    Science.gov (United States)

    Bashev, A.

    2012-04-01

    Currently there is an enormous amount of various geoscience databases. Unfortunately the only users of the majority of the databases are their elaborators. There are several reasons for that: incompaitability, specificity of tasks and objects and so on. However the main obstacles for wide usage of geoscience databases are complexity for elaborators and complication for users. The complexity of architecture leads to high costs that block the public access. The complication prevents users from understanding when and how to use the database. Only databases, associated with GoogleMaps don't have these drawbacks, but they could be hardly named "geoscience" Nevertheless, open and simple geoscience database is necessary at least for educational purposes (see our abstract for ESSI20/EOS12). We developed a database and web interface to work with them and now it is accessible at maps.sch192.ru. In this database a result is a value of a parameter (no matter which) in a station with a certain position, associated with metadata: the date when the result was obtained; the type of a station (lake, soil etc); the contributor that sent the result. Each contributor has its own profile, that allows to estimate the reliability of the data. The results can be represented on GoogleMaps space image as a point in a certain position, coloured according to the value of the parameter. There are default colour scales and each registered user can create the own scale. The results can be also extracted in *.csv file. For both types of representation one could select the data by date, object type, parameter type, area and contributor. The data are uploaded in *.csv format: Name of the station; Lattitude(dd.dddddd); Longitude(ddd.dddddd); Station type; Parameter type; Parameter value; Date(yyyy-mm-dd). The contributor is recognised while entering. This is the minimal set of features that is required to connect a value of a parameter with a position and see the results. All the complicated data

  17. Supporting the Reuse of Open Educational Resources through Open Standards

    NARCIS (Netherlands)

    Glahn, Christian; Kalz, Marco; Gruber, Marion; Specht, Marcus

    2010-01-01

    Glahn, C., Kalz, M., Gruber, M., & Specht, M. (2010). Supporting the Reuse of Open Educational Resources through Open Standards. In T. Hirashima, A. F. Mohd Ayub, L. F. Kwok, S. L. Wong, S. C. Kong, & F. Y. Yu (Eds.), Workshop Proceedings of the 18th International Conference on Computers in Educatio

  18. Supporting the Reuse of Open Educational Resources through Open Standards

    NARCIS (Netherlands)

    Glahn, Christian; Kalz, Marco; Gruber, Marion; Specht, Marcus

    2010-01-01

    Glahn, C., Kalz, M., Gruber, M., & Specht, M. (2010). Supporting the Reuse of Open Educational Resources through Open Standards. In T. Hirashima, A. F. Mohd Ayub, L. F. Kwok, S. L. Wong, S. C. Kong, & F. Y. Yu (Eds.), Workshop Proceedings of the 18th International Conference on Computers in

  19. Open source and open standards in e-learning research

    NARCIS (Netherlands)

    Koper, Rob

    2007-01-01

    Presentation at the TENCompetence Winterschool directed at Ph.D. students to position e-learning research and the role of open source and open standards to facilitate the research process in a methodological sense. The presentation is based on the paper: http://hdl.handle.net/1820/780

  20. Open Genetic Code: on open source in the life sciences

    NARCIS (Netherlands)

    Deibel, E.

    2014-01-01

    The introduction of open source in the life sciences is increasingly being suggested as an alternative to patenting. This is an alternative, however, that takes its shape at the intersection of the life sciences and informatics. Numerous examples can be identified wherein open source in the life

  1. Open source and open standards in e-learning research

    NARCIS (Netherlands)

    Koper, Rob

    2007-01-01

    Presentation at the TENCompetence Winterschool directed at Ph.D. students to position e-learning research and the role of open source and open standards to facilitate the research process in a methodological sense. The presentation is based on the paper: http://hdl.handle.net/1820/780

  2. The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance.

    Directory of Open Access Journals (Sweden)

    Gunilla Jäger

    Full Text Available The main features of translation are similar in all organisms on this planet and one important feature of it is the way the ribosome maintain the reading frame. We have earlier characterized several bacterial mutants defective in tRNA maturation and found that some of them correct a +1 frameshift mutation; i.e. such mutants possess an error in reading frame maintenance. Based on the analysis of the frameshifting phenotype of such mutants we proposed a pivotal role of the ribosomal grip of the peptidyl-tRNA to maintain the correct reading frame. To test the model in an unbiased way we first isolated many (467 independent mutants able to correct a +1 frameshift mutation and thereafter tested whether or not their frameshifting phenotypes were consistent with the model. These 467+1 frameshift suppressor mutants had alterations in 16 different loci of which 15 induced a defective tRNA by hypo- or hypermodifications or altering its primary sequence. All these alterations of tRNAs induce a frameshift error in the P-site to correct a +1 frameshift mutation consistent with the proposed model. Modifications next to and 3' of the anticodon (position 37, like 1-methylguanosine, are important for proper reading frame maintenance due to their interactions with components of the ribosomal P-site. Interestingly, two mutants had a defect in a locus (rpsI, which encodes ribosomal protein S9. The C-terminal of this protein contacts position 32-34 of the peptidyl-tRNA and is thus part of the P-site environment. The two rpsI mutants had a C-terminal truncated ribosomal protein S9 that destroys its interaction with the peptidyl-tRNA resulting in +1 shift in the reading frame. The isolation and characterization of the S9 mutants gave strong support of our model that the ribosomal grip of the peptidyl-tRNA is pivotal for the reading frame maintenance.

  3. OpenCL programming guide

    CERN Document Server

    Munshi, Aaftab; Mattson, Timothy G; Fung, James; Ginsburg, Dan

    2011-01-01

    Using the new OpenCL (Open Computing Language) standard, you can write applications that access all available programming resources: CPUs, GPUs, and other processors such as DSPs and the Cell/B.E. processor. Already implemented by Apple, AMD, Intel, IBM, NVIDIA, and other leaders, OpenCL has outstanding potential for PCs, servers, handheld/embedded devices, high performance computing, and even cloud systems. This is the first comprehensive, authoritative, and practical guide to OpenCL 1.1 specifically for working developers and software architects. Written by five leading OpenCL authorities, OpenCL Programming Guide covers the entire specification. It reviews key use cases, shows how OpenCL can express a wide range of parallel algorithms, and offers complete reference material on both the API and OpenCL C programming language. Through complete case studies and downloadable code examples, the authors show how to write complex parallel programs that decompose workloads across many different devices. They...

  4. Lifelong Open and Flexible Learning

    DEFF Research Database (Denmark)

    Bang, Jørgen

    2006-01-01

    and Flexible (LOF) learning embracing characteristics as: open learning, distance learning, e-learning, online learning, open accessibility, multimedia support, virtual mobility, learning communities, dual mode (earn & learn) approaches, and the like.In my presentation I will focus on the EADTU strategies...

  5. The open innovation research landscape

    DEFF Research Database (Denmark)

    Bogers, Marcel; Zobel, Ann-Kristin; Afuah, Allan;

    2017-01-01

    This paper provides an overview of the main perspectives and themes emerging in research on open innovation (OI). The paper is the result of a collaborative process among several OI scholars – having a common basis in the recurrent Professional Development Workshop on ‘Researching Open Innovation...

  6. Opening the door to innovation.

    Science.gov (United States)

    Schuurman, Janine; Graus, Yvo F; Labrijn, Aran F; Ruuls, Sigrid; Parren, Paul W H I

    2014-01-01

    Open innovation is the new buzz, with initiatives popping up left and right. Here, we give a personal perspective on a very successful, knowledge-driven innovation initiated in an academia- industry alliance, which culminated in technology platforms that enable the generation of therapeutic antibodies with novel properties. To start, we provide a general background on open innovation in the drug development field.

  7. OPEN DATA FOR DISCOVERY SCIENCE.

    Science.gov (United States)

    Payne, Philip R O; Huang, Kun; Shah, Nigam H; Tenenbaum, Jessica

    2016-01-01

    The modern healthcare and life sciences ecosystem is moving towards an increasingly open and data-centric approach to discovery science. This evolving paradigm is predicated on a complex set of information needs related to our collective ability to share, discover, reuse, integrate, and analyze open biological, clinical, and population level data resources of varying composition, granularity, and syntactic or semantic consistency. Such an evolution is further impacted by a concomitant growth in the size of data sets that can and should be employed for both hypothesis discovery and testing. When such open data can be accessed and employed for discovery purposes, a broad spectrum of high impact end-points is made possible. These span the spectrum from identification of de novo biomarker complexes that can inform precision medicine, to the repositioning or repurposing of extant agents for new and cost-effective therapies, to the assessment of population level influences on disease and wellness. Of note, these types of uses of open data can be either primary, wherein open data is the substantive basis for inquiry, or secondary, wherein open data is used to augment or enrich project-specific or proprietary data that is not open in and of itself. This workshop is concerned with the key challenges, opportunities, and methodological best practices whereby open data can be used to drive the advancement of discovery science in all of the aforementioned capacities.

  8. Digital Scholarship and Open Access

    Science.gov (United States)

    Losoff, Barbara; Pence, Harry E.

    2010-01-01

    Open access publications provide scholars with unrestricted access to the "conversation" that is the basis for the advancement of knowledge. The large number of open access journals, archives, and depositories already in existence demonstrates the technical and economic viability of providing unrestricted access to the literature that is the…

  9. Next Stop: OpenSim!

    Science.gov (United States)

    Korolov, Maria

    2011-01-01

    Unhappy with conditions in Second Life, educators are migrating to a developing virtual world that offers them greater autonomy and a safer platform for their students at far less a cost. OpenSimulator is an open source virtual world platform that schools can run for free on their own servers or can get cheaply and quickly--the space can be up and…

  10. Organizing Open Innovation for Sustainability

    NARCIS (Netherlands)

    Ingenbleek, P.T.M.; Backus, G.B.C.

    2015-01-01

    Literature on open innovation has thus far predominantly focused on high technology contexts. Once an industry reaches the limits of a closed innovation model, open innovation may, however, also promise opportunities for sustainable development in a low-tech environment. Because in low-tech

  11. Esthetic correction in open bite

    Directory of Open Access Journals (Sweden)

    Swapnil Parlani

    2011-01-01

    Full Text Available Deleterious oral habits, which are persistent, can lead to poor esthetics of a beautiful face. Conventional treatment modalities for an open bite usually include orthodontic treatment and/or skeletal surgery. This article focuses on a different treatment modality for an anterior open bite.

  12. OpenSM Monitoring System

    Energy Technology Data Exchange (ETDEWEB)

    2015-04-17

    The OpenSM Monitoring System includes a collection of diagnostic and monitoring tools for use on Infiniband networks. The information this system gathers is obtained from a service, which in turn is obtained directly from the OpenSM subnet manager.

  13. Digital Scholarship and Open Access

    Science.gov (United States)

    Losoff, Barbara; Pence, Harry E.

    2010-01-01

    Open access publications provide scholars with unrestricted access to the "conversation" that is the basis for the advancement of knowledge. The large number of open access journals, archives, and depositories already in existence demonstrates the technical and economic viability of providing unrestricted access to the literature that is the…

  14. Organizing Open Innovation for Sustainability

    NARCIS (Netherlands)

    Ingenbleek, P.T.M.; Backus, G.B.C.

    2015-01-01

    Literature on open innovation has thus far predominantly focused on high technology contexts. Once an industry reaches the limits of a closed innovation model, open innovation may, however, also promise opportunities for sustainable development in a low-tech environment. Because in low-tech environm

  15. Recent developments from the OPEnS Lab

    Science.gov (United States)

    Selker, J. S.; Good, S. P.; Higgins, C. W.; Sayde, C.; Buskirk, B.; Lopez, M.; Nelke, M.; Udell, C.

    2016-12-01

    The Openly Published Environmental Sensing (OPEnS) lab is a facility that is open to all from around the world to use (http://agsci.oregonstate.edu/open-sensing). With 3-D CAD, electronics benches, 3-D printers and laser cutters, and a complete precision metal shop, the lab can build just about anything. Electronic platforms such as the Arduino are combined with cutting edge sensors, and packaged in rugged housing to address critical environmental sensing needs. The results are published in GITHub and in the AGU journal Earth and Space Sciences under the special theme of "Environmental Sensing." In this poster we present advancements including: A ultra-precise isotopic sampler for rainfall; an isotopic sampler for soil gas; a data-logging wind vane that can be mounted on the tether of a balloon; a rain-gage calibrator with three rates of constant application; a <$20 dissolved O2 probe for water; a stream-bed permeameter that gives rapid quantification of permeability. You can use the OPEnS lab! Just sketch your idea on a white board and send it in. The conversation is started, and your prototype can be ready in a few weeks. We have a staff of three engineers ready to help, where you are working remotely, or decide to spend some time with the team in Corvallis.

  16. Open Genetic Code: on open source in the life sciences.

    Science.gov (United States)

    Deibel, Eric

    2014-01-01

    The introduction of open source in the life sciences is increasingly being suggested as an alternative to patenting. This is an alternative, however, that takes its shape at the intersection of the life sciences and informatics. Numerous examples can be identified wherein open source in the life sciences refers to access, sharing and collaboration as informatic practices. This includes open source as an experimental model and as a more sophisticated approach of genetic engineering. The first section discusses the greater flexibly in regard of patenting and the relationship to the introduction of open source in the life sciences. The main argument is that the ownership of knowledge in the life sciences should be reconsidered in the context of the centrality of DNA in informatic formats. This is illustrated by discussing a range of examples of open source models. The second part focuses on open source in synthetic biology as exemplary for the re-materialization of information into food, energy, medicine and so forth. The paper ends by raising the question whether another kind of alternative might be possible: one that looks at open source as a model for an alternative to the commodification of life that is understood as an attempt to comprehensively remove the restrictions from the usage of DNA in any of its formats.

  17. OOI's Cyberinfrastructure: An Opening

    Science.gov (United States)

    Graybeal, J.; Ampe, T.; Arrott, M.; Chave, A. D.; Cressey, R.; Jul, S.; McPhail, T.; Meisinger, M.; Orcutt, J. A.; Peach, C. L.; Schofield, O.; Stocks, K.; Thomas, J.; Vernon, F.

    2012-12-01

    The Ocean Observatories Initiative is a long-term, NSF-funded program to provide 25-30 years of sustained ocean measurements to study climate variability, ocean circulation and ecosystem dynamics, air-sea exchange, seafloor processes, and plate-scale geodynamics. The OOI will enable powerful new scientific approaches for exploring the complexities of Earth-ocean-atmosphere interactions, thereby accelerating progress toward the goal of understanding, predicting, and managing our ocean environment. The OOI can foster new discoveries that, in turn, move research in unforeseen directions. The OOI Cyberinfrastructure will connect and coordinate the operations of OOI marine components and data processes, to meet the objectives of the oceanographic research and education communities. The CI will let all users easily interact with deployed resources, access collected data, and apply those data to their specific research and educational needs. The CI is a free and open product that adopts innovative and flexible strategies to bring the oceans to users, any time, any place, on any suitable device. The OOI CI is dedicated to "using the latest computing technologies to solve the interoperability problem among vast amounts of heterogeneous geospatial data from various sources." OOI CI's charge is to be transformative, and its technologies and goals are just that (see URL). The Cyberinfrastructure integrates state-of-the-art and best-practice approaches to provide fully interoperable access to the widest possible collection of geospatial data. From the system-of-systems model of the planned observatories and the ingestion of data, models, and services; to the configurable, automated workflows producing real-time products, data curation and quality management strategies are supported to the fullest possible extent. How do we build a system to efficiently support 750 core instruments across numerous platform types, add as-yet unknown instruments during the operations phase, and

  18. Open source MySQL Browser for Open Innovation

    Directory of Open Access Journals (Sweden)

    Radu Bucea-Manea-Tonis

    2014-07-01

    Full Text Available Abstract. Our purpose is to cross-compile MySQL driver source code for Linux on Windows architecture using a tool chain in order to build a neutral valid graphic interface on 32 bits. Once achieving this goal we could say that every possible Open source application can be built and run on Windows with maximum efficiency concerning costs and resource. This browser is an example of open innovation because its source code is free for anybody willing to develop new software apps for business and uses only Open source tools.

  19. 2007: A pivotal year (continued)

    CERN Multimedia

    Staff Association

    2007-01-01

    In our first Echo editorial in January 2007, we pointed out that the manpower plan, the future of our social conditions (health insurance, pensions), the implementation of the last five-yearly review and the review of our voluntary schemes would be subjects on which we would have to keep a close watch and show solidarity. In light of what has been happening, we were right to be cautious.

  20. AFP mRNA level in enriched circulating tumor cells from hepatocellular carcinoma patient blood samples is a pivotal predictive marker for metastasis.

    Science.gov (United States)

    Jin, Junhua; Niu, Xiaojuan; Zou, Lihui; Li, Lin; Li, Shugang; Han, Jingli; Zhang, Peiying; Song, Jinghai; Xiao, Fei

    2016-08-01

    Circulating tumor cells (CTCs) quantification may be helpful for evaluating cancer dissemination, predicting prognosis and assessing therapeutic effectiveness and safety. In the present study, CTCs from blood samples of 72 patients with hepatocellular carcinoma (HCC) were enriched with anti-EpCAM nanoparticles. AFP mRNA level was detected by nested polymerase chain reaction (PCR) after enrichment of CTCs from HCC blood samples at 0, 3, 6, 9 and 12 months after hepatectomy, respectively. AFP mRNA expression in CTCs was positive in 43 patients (59.7%) and negative in 29 patients (40.3%) before hepatectomy. Among 43 patients with positive AFP mRNA expression in CTCs before hepatectomy, 10 and 11 were diagnosed as intrahepatic/extrahepatic metastasis before and after hepatectomy, respectively. In addition, these 21 patients with metastasis had persisting positive AFP mRNA of CTCs during the whole tested year. Specifically, 3 patients with AFP mRNA negative in CTCs before hepatectomy changed to be positive at 6 and 9 months, and 2 of them were diagnosed as metastasis 12 months after hepatectomy. We conclude that the positive AFP mRNA of CTCs can be a pivotal predictor for HCC metastasis before and after hepatectomy. The release of AFP expression from hepatocellular carcinoma cells into circulation must be a major source of HCC metastasis.

  1. Cucumis sativus L. WAX2 Plays a Pivotal Role in Wax Biosynthesis, Influencing Pollen Fertility and Plant Biotic and Abiotic Stress Responses.

    Science.gov (United States)

    Wang, Wenjiao; Liu, Xingwang; Gai, Xinshuang; Ren, Jiaojiao; Liu, Xiaofeng; Cai, Yanling; Wang, Qian; Ren, Huazhong

    2015-07-01

    Cuticular waxes play an important part in protecting plant aerial organs from biotic and abiotic stresses. In previous studies, the biosynthetic pathway of cuticular waxes and relative functional genes has been researched and understood; however, little is known in cucumber (Cucumis sativus L.). In this study, we cloned and characterized an AtWAX2 homolog, CsWAX2, in cucumber and found that it is highly expressed in the epidermis, where waxes are synthesized, while subcellular localization showed that CsWAX2 protein is localized to the endoplasmic reticulum (ER). The transcriptional expression of CsWAX2 was found to be induced by low temperature, drought, salt stress and ABA, while the ectopic expression of CsWAX2 in an Arabidopsis wax2 mutant could partially complement the glossy stem phenotype. Abnormal expression of CsWAX2 in transgenic cucumbers specifically affected both very long chain (VLC) alkanes and cutin biosynthesis. Furthermore, transgenic cucumber plants of CsWAX2 showed significant changes in pollen viability and fruit resistance to water loss and pathogens compared with the wild type. Collectively, these results indicated that CsWAX2 plays a pivotal role in wax biosynthesis, influencing pollen fertility and the plant's response to biotic and abiotic stresses.

  2. Closed-Loop Flow Control of the Coupled Wake Dynamics and Aerodynamic Loads of a Freely-Pivoting 3-DOF Bluff Body

    Science.gov (United States)

    Lambert, T.; Vukasinovic, B.; Glezer, A.

    2016-11-01

    The motion of an axisymmetric bluff body model that is free to pivot in pitch, yaw, and roll in a uniform stream in response to flow-induced aerodynamic loads is controlled in wind tunnel experiments using fluidic actuation. The model is attached to an upstream, wire-supported short streamwise sting through a low-friction hinge, and each of the support wires is individually-controlled by a servo actuator through an in-line load cell. The aerodynamic loads on the body, and thereby its motion, are controlled through fluidic modification of its aerodynamic coupling to its near wake using four independent aft mounted synthetic jet actuators that effect azimuthally-segmented flow attachment over the model's tail end. The effects of actuation-induced, transitory changes in the model's aerodynamic loads are measured by its motion response using motion tracking, while the coupled evolution of the near-wake is captured by high-speed stereo PIV. Flow control authority is demonstrated by feedback-controlled manipulation of the model's dynamic response, and dynamic mode decomposition (DMD) of the wake is used to characterize changes in the wake structure and stability. It is shown that this flow control approach can modify the stability and damping of the model's motion (e.g., suppression or amplification of its natural oscillations), and impose desired directional attitude. Supported by the ARO.

  3. Evaluación de la calidad del riego en máquinas eléctricas de pivote central del modelo o tipo Ballama"

    Directory of Open Access Journals (Sweden)

    Norge Tornés O

    2009-01-01

    Full Text Available El trabajo se realizó en áreas regadas con la máquina eléctrica de pivote central tipo Ballama de 8 torres, en un suelo aluvial poco diferenciado cultivado de papa en la Unidad Básica de Producción Cooperativa (UBPC "Antonio Maceo", de la Empresa de Cultivos Varios "Paquito Rosales", ubicada en el poblado de Veguitas, municipio Yara, provincia Granma. El experimento se desarrolló en el período de diciembre de 2005 a marzo de 2006, El marco de siembra utilizado fue: 0,90 m entre hileras y 0,25m entre plantas. El análisis de la lluvia a lo largo de la máquina arrojó una distribución no uniforme, semejante comportamiento presentó la altura por planta obteniéndose los menores valores en tramos de valor del coeficiente de uniformidad.

  4. Evaluación de los indicadores hidráulicos de las máquinas de pivote central eléctrica

    Directory of Open Access Journals (Sweden)

    Albi Mujica Cervantes

    2014-01-01

    Full Text Available Se exponen los resultados obtenidos de la evaluación de maquinas de pivote central eléctricas producidas por la firma Otech- Irrimec. La evolución del conjunto bomba-motor se realizó conforme a lo establecido por la ABNT (1975. Fueron medidos la potencia del motor, el caudal y la presión a la salida de la bomba. La pérdida de carga en la succión fue determinada utilizando la ecuación de Darcy-Weisbach y la carga manométrica de la bomba empleando la ecuación de Bernoulli. La medición del caudal se realizó utilizando un flujometro y la presión se determino por un manómetro instalado a la salida de la bomba. Finalmente la energía especifica requerida en los componentes de la maquina resulto del orden de los 3.52 kWh/mm/ha.

  5. Organización de la explotación en maquinas de pivote central eléctricas para el riego del cultivo de la papa

    Directory of Open Access Journals (Sweden)

    Lorenzo E. Camejo B.

    2009-01-01

    Full Text Available Se realizó el trabajo para la organización de la explotación de las máquinas de riego de pivote central Western5 en el cultivo de la papa (solanum tuberosum en la provincia Ciego de Ávila, teniéndose en consideración el tipo de suelo, sus propiedades hidrofísicas, fases de desarrollo del cultivo, exigencias hídricas y regulaciones de la máquina, lo que conlleva a obtener las normas de riego, intervalos de riego y regulaciones para cada fase de desarrollo del cultivo; aplicándose en todas las máquinas de riego de papas en la provincia, capacitando además a todos los operadores y técnicos en la explotación y regulación de la máquina por fases de desarrollo del cultivo. Los resultados obtenidos muestran un considerable ahorro de agua y energía en la campaña de riego, obteniéndose rendimientos entre 28-32 t/ha.

  6. Contributory factors to the results of gravity-assisted pivot-shift test for anterior cruciate ligament injury: the significance of muscle torque around the knee.

    Science.gov (United States)

    Hiraoka, Hisatada; Yashiki, Motohisa; Sakai, Hiroya

    2008-03-01

    Gravity-assisted pivot-shift (GAPS) test is a newly advocated test for anterior cruciate ligament (ACL) injury. It induces anterolateral rotatory instability with valgus stress to the knee applied by gravitational force during patient's active knee motion. We investigated prospectively the relationships between the results of the GAPS test and the possible contributory factors and sought to clarify the determinant factors of the GAPS test. A total of 54 knee joints of 54 patients with unilateral ACL injury (29 males, 25 females, average 23.4 +/- 9.0 years old) were enrolled in this study and were divided into two groups, i.e., positive GAPS test group and negative GAPS test group. Muscle torque around the knee joints measured before surgery, configuration of the femoral condyle and tibial posterior slope angle measured on lateral radiograph, and other clinical factors were compared between the two groups using Mann-Whitney U test or chi-square test. According to the results of these analyses, factors having a statistically significant difference were additionally evaluated using multiple logistic regression analysis to reveal items with strong relevance to a positive GAPS test. The results of the multiple logistic regression analysis showed that the flexor/extensor peak torque ratio of contralateral uninjured knees and sex had a significant correlation with the results of the GAPS test. The relatively less flexor muscle torque compared with extensor muscle torque, and being a female patient were considered to be the determinant factors of a positive GAPS test.

  7. Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka (Oryzias latipes) embryo.

    Science.gov (United States)

    Yasuda, Takako; Kimori, Yoshitaka; Nagata, Kento; Igarashi, Kento; Watanabe-Asaka, Tomomi; Oda, Shoji; Mitani, Hiroshi

    2016-01-01

    The tumor suppressor protein, p53, plays pivotal roles in regulating apoptosis and proliferation in the embryonic and adult central nervous system (CNS) following neuronal injuries such as those induced by ionizing radiation. There is increasing evidence that p53 negatively regulates the self-renewal of neural stem cells in the adult murine brain; however, it is still unknown whether p53 is essential for self-renewal in the injured developing CNS. Previously, we demonstrated that the numbers of apoptotic cells in medaka (Oryzias latipes) embryos decreased in the absence of p53 at 12-24 h after irradiation with 10-Gy gamma rays. Here, we used histology to examine the later morphological development of the irradiated medaka brain. In p53-deficient larvae, the embryonic brain possessed similar vacuoles in the brain and retina, although the vacuoles were much smaller and fewer than those found in wild-type embryos. At the time of hatching (6 days after irradiation), no brain abnormality was observed. In contrast, severe disorganized neuronal arrangements were still present in the brain of irradiated wild-type embryos. Our present results demonstrated that self-renewal of the brain tissue completed faster in the absence of p53 than wild type at the time of hatching because p53 reduces the acute severe neural apoptosis induced by irradiation, suggesting that p53 is not essential for tissue self-renewal in developing brain.

  8. Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo.

    Science.gov (United States)

    Yang, Lili; Wei, Yi; Sun, Yue; Shi, Weimin; Yang, Ji; Zhu, Lubing; Li, Ming

    2015-07-01

    Increased expression of the cytokine interferon (IFN)-γ plays a pivotal role in vitiligo-induced depigmentation. However, the major source of IFN-γ in vitiligo patients and the mechanisms underlying melanocyte destruction are unknown. In this study, a large number of skin infiltrating IFN-γ+ cells and CD8+ T cells were detected in progressive vitiligo. Among the peripheral blood mononuclear cells (PBMCs) of vitiligo patients, CD8+ cytotoxic T lymphocytes (CTLs) that express IFN-γ exhibited significant expansion, which suggests that activated CTLs are the main source of increased IFN-γ in progressive vitiligo. An in vitro analysis demonstrated that IFN-γ inhibits melanogenesis in primary cultured human melanocytes by altering melanogenic enzyme mRNA expression and, more importantly, that IFN-γ directly induces melanocyte apoptosis. Our data indicate that vitiligo pathophysiology may be linked to globally activated CD8+ CTL subpopulations, which produce increased IFN-γ and induce melanocyte dysfunction and apoptosis.

  9. Pivot Tables - Toolkit: the Constraints to the Business Development in the Former Socialist EU Countries from the Central and Eastern Europe between (2008-2016

    Directory of Open Access Journals (Sweden)

    Ecaterina Daniela Zeca

    2016-07-01

    Full Text Available When cooperation between countries is in harmony, trade and investment patterns are based on economic considerations. However, in times of geopolitical reconfiguration of ranking supremacy, economic events held on a stage that sums up all the world, with everything that means material resources, financial resources, polarized areas of intervention, causation so "equation", sometimes with many and unpredictable variables, may not be so easy to solve it. The measurements and econometric calculation are indisputable correct, analysis and the economic forecasts must be accompanied by correct investment strategies on international road map being important to not overlook tension that may weaken national strategy. Informational abundance is as dangerous, or more correctly ineffective, like is the shortage of information. I approached the topic " Pivot tables - toolkit: the constraints to the business development in the former EU socialist countries from the Central and Eastern Europe" in terms of the possibility of accessing easy, accurate and timely a lot of sources of information because, this aspect is desirable, that the result of research overcome the academic space and to become a useful and efficient tool both to researchers, the decision makers and for vectors of economic policy. How large were the constraints and limitations which occurred, which is architecture of their evolution curve for the horizon 2008, 2016, all of these are coagulated aspects in this paper and accessible with one click.

  10. SDA, a DNA aptamer inhibiting E- and P-selectin mediated adhesion of cancer and leukemia cells, the first and pivotal step in transendothelial migration during metastasis formation.

    Directory of Open Access Journals (Sweden)

    Rassa Faryammanesh

    Full Text Available Endothelial (E- and platelet (P- selectin mediated adhesion of tumor cells to vascular endothelium is a pivotal step of hematogenous metastasis formation. Recent studies have demonstrated that selectin deficiency significantly reduces metastasis formation in vivo. We selected an E- and P-Selectin specific DNA Aptamer (SDA via SELEX (Systematic Evolution of Ligands by EXponential enrichment with a K(d value of approximately 100 nM and the capability of inhibiting the interaction between selectin and its ligands. Employing human colorectal cancer (HT29 and leukemia (EOL-1 cell lines we could demonstrate an anti-adhesive effect for SDA in vitro. Under physiological shear stress conditions in a laminar flow adhesion assay, SDA inhibited dynamic tumor cell adhesion to immobilized E- or P-selectin. The stability of SDA for more than two hours allowed its application in cell-cell adhesion assays in cell culture medium. When adhesion of HT29 cells to TNFα-stimulated E-selectin presenting human pulmonary microvascular endothelial cells was analyzed, inhibition via SDA could be demonstrated as well. In conclusion, SDA is a potential new therapeutic agent that antagonizes selectin-mediated adhesion during metastasis formation in human malignancies.

  11. Opening science to the world; opening the world to science

    CERN Multimedia

    Andrew Purcell

    2015-01-01

    ‘Engaging the research community towards an Open Science Commons’ was the main theme of the European Grid Infrastructure (EGI) annual conference that was held in Lisbon from 18 to 22 May. At the conference, the EGI­Engage project was launched and the European Open Science Cloud was discussed.   Tiziana Ferrari, technical director of EGI.eu, speaks at the EGI Annual conference in Lisbon this year. The EGI­Engage project was launched during the opening session of the conference by Tiziana Ferrari, technical director of EGI.eu. This project, which has been funded through the EU’s Horizon 2020 Framework Programme for Research and Innovation, aims to accelerate progress towards the implementation of the Open Science Commons. It seeks to do so by expanding the capabilities of a European backbone of federated services for computing, storage, data, communication, knowledge and expertise, as well as related community­-specific capabilities. &l...

  12. OpenRIMS: An Open Architecture Radiology Informatics Management System

    OpenAIRE

    Langer, Steve

    2002-01-01

    The benefits of an integrated picture archiving and communication system/radiology information system (PACS/RIS) archive built with open source tools and methods are 2-fold. Open source permits an inexpensive development model where interfaces can be updated as needed, and the code is peer reviewed by many eyes (analogous to the scientific model). Integration of PACS/RIS functionality reduces the risk of inconsistent data by reducing interfaces among databases that contain largely redundant i...

  13. A review of the open charm and open bottom mesons

    CERN Document Server

    Chen, Hua-Xing; Liu, Xiang; Liu, Yan-Rui; Zhu, Shi-Lin

    2016-01-01

    Since the discovery of the first charmed meson in 1976, many open-charm and open-bottom mesons were observed. In 2003 two narrow charm-strange states $D_{s0}^*(2317)$ and $D_{s1}(2460)$ were discovered by the BaBar and CLEO Collaborations, respectively. After that, more excited heavy mesons were reported. In this work, we review the experimental and theoretical progress in this field.

  14. Pivot splint with straight wire appliance for adolescent AngleII2 malocclusion with temporomandibular joint disorcler%枢轴合板配合直丝弓矫治器治疗青少年AngleII2错颌畸形伴颞下颌关节紊乱的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈新; 冯刚; 谢康森

    2011-01-01

    Objective To summarize the clinical effect of straight wire appliance with pivot splint for adolescents with Anglell malocclusion with temporomandibular joint disorder (TMD). Methods Fifteen cases of Anglell2 malocclusion with TMD aged form 12 to 21 (4 male cases and 11 female cases) were selected and treated by maxillary extraction orthodontics with rectangular archwire brackets. At the time of orthodontic treatment of maxillaryteeth, pivot splint were worn to adjust synarthry and were taken down after 1 ~3 months'treatment. We evaluated the curative effect when pivot splint was taken down and orthodontic treatment finished. Scholler position of some patients was appraised before and after treatment Results The cure rate of clicking of joint, pain, open-mouth limited movement and lock was 66. 7% , 90% , 60. 0% and 75% respectively when . The cure rate when orthodontic treatment finished is 86. 6% , 100% , 80. 0% and 87. 5% respectively. Among them, 5 cases were checked by X-ray and 3 cases recovered to normal, 2 case improved significantly. Conclusion The straight wire appliance with pivot splint is a feasible therapy method for adolescents with Anglell2 malocclusion with TMD.%目的 探讨枢轴合板配合直丝弓矫治器治疗青少年AngleII2错颌畸形伴颞下颌关节紊乱病(TMD)的临床疗效.方法 选择临床检查AngleII2错颌崎形伴TMD患者15例,年龄12~21岁,均采用直丝弓托槽,上颌牙固定矫治开始的同时,佩戴枢轴合板进行关节调整,治疗1~3月后脱离枢轴合板,评价合板脱离时及正畸治疗完成时的疗效,对部分患者治疗前后的许勒位片进行评价.结果 15例患者疗程治疗结束时总治愈率80%(12/15),各症状如弹响、疼痛、张口受限、绞锁的治愈率分别:86.67%,100%,80.0%和87.5%.对其中5例患者进行了X射线片复查,3例患者恢复了正常的盘突关系,2例患者关节盘较治疗前位置回复明显.结论 枢轴合板配合直丝弓矫

  15. Instant OpenNMS starter

    CERN Document Server

    Hachey, Ghislain

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A starters' guide to learning OpenNMS with ease, with a focus on immediate results.Instant OpenNMS Starter is for network administrators of any level with a slight focus on the novice that would enjoy a swift glance at what OpenNMS has to offer. It assumes the reader will have knowledge of basic network operations and protocols such as the Internet Protocol Suite.

  16. Infections in open heart surgery.

    Science.gov (United States)

    Baddour, L M; Kluge, R M

    1989-01-01

    More than 250,000 open heart surgical procedures are performed annually in the United States. The majority of these procedures are coronary artery bypass grafts (CABG) and valve replacements. In this forum our authors discuss the kinds of infections that occur in patients following open heart surgery, as well as the documented risk factors and microbiology of these infections. We also asked each author to outline the criteria used to diagnose post open heart surgery infections, and to address associated consequences and complications. Finally, we were interested in each author's definition of the infection control practitioner's role in the prevention of this particular subset of nosocomial infections.

  17. Working with OpenERP

    CERN Document Server

    Moss, Greg

    2013-01-01

    This book is a practical, hands-on guide that provides the reader with a number of real-world examples and step-by-step instructions.""Working with OpenERP"" is written to make it easy for even a non-technical business person to begin implementing OpenERP in their business. This book uses real-world examples and is perfect for people who have never implemented an ERP system before or used OpenERP, or for those who would like to learn more advanced features, such as creating your own custom modules.

  18. Collaborations in Open Learning Environments

    NARCIS (Netherlands)

    Spoelstra, Howard

    2015-01-01

    This thesis researches automated services for professionals aiming at starting collaborative learning projects in open learning environments, such as MOOCs. It investigates the theoretical backgrounds of team formation for collaborative learning. Based on the outcomes, a model is developed describin

  19. OpenGL Modelview Transformations

    OpenAIRE

    2003-01-01

    This interactive tutorial reviews Model View Transformation. Students would be able to modify the parameters of various OpenGL commands and view the results. Last modified: 5/18/2009 MV4202 Computer Graphics

  20. Collaborations in Open Learning Environments

    NARCIS (Netherlands)

    Spoelstra, Howard

    2015-01-01

    This thesis researches automated services for professionals aiming at starting collaborative learning projects in open learning environments, such as MOOCs. It investigates the theoretical backgrounds of team formation for collaborative learning. Based on the outcomes, a model is developed

  1. OpenEIS. Users Guide

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woohyun [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lutes, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Katipamula, Srinivas [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Haack, Jereme N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carpenter, Brandon J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Akyol, Bora A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Monson, Kyle E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Allwardt, Craig H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kang, Timothy [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sharma, Poorva [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-02-28

    This document is a users guide for OpenEIS, a software code designed to provide standard methods for authoring, sharing, testing, using and improving algorithms for operational building energy efficiency.

  2. Incumbent Participation in Open Innovation

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders

    Recent years have seen an increasing shift towards open innovation approaches across a wide range of types and sizes of companies, as well as a surge in the interest from academics into the topic. Accessing knowledge and resources otherwise unavailable through interactions with external partners...... is generally regarded as highly valuable to the development and commercialization of innovations. However, this paper explores a potential dark side of open innovation. Based on well-establish theory, differences between the interests of incumbents and SMEs are hypothesized to influence the future survival...... and performance of the SME partners. Findings support the hypothesis that open innovation engagement with incumbents has a negative impact on future survival and performance, moderated by radicalness and technological maturity. This elaborates on open innovation by increased understanding of drawbacks...

  3. Open Source Vulnerability Database Project

    Directory of Open Access Journals (Sweden)

    Jake Kouns

    2008-06-01

    Full Text Available This article introduces the Open Source Vulnerability Database (OSVDB project which manages a global collection of computer security vulnerabilities, available for free use by the information security community. This collection contains information on known security weaknesses in operating systems, software products, protocols, hardware devices, and other infrastructure elements of information technology. The OSVDB project is intended to be the centralized global open source vulnerability collection on the Internet.

  4. Open strategy: Dimensions, dilemmas, dynamics

    OpenAIRE

    Hautz, J; D. Seidl; Whittington, R.

    2016-01-01

    Responding to increasing practitioner and academic interest in Open Strategy, this article builds on recent theoretical and empirical studies in order to advance research in the following ways. We begin by developing a definition of Open Strategy that emphasizes variation along the two dimensions of transparency and inclusion, as well as the dilemmas and dynamics inherent in its practices. We identify five dilemmas in particular: those of process, commitment, disclosure, empowerment and escal...

  5. Un Open GIS Capacity Building

    Science.gov (United States)

    Albertella, A.; Brovelli, M. A.; Gonzalez Ferreiro, D.

    2017-07-01

    The UN Open GIS Initiative is to identify and develop, under UN guidance, an Open Source GIS bundle that meets the requirements of UN operations, taking full advantage of the expertise of mission partners (partner nations, technology contributing countries, international organizations, academia, NGO's, private sector). The project, started in 2016, is composed by 4 working groups. One of the working group is specifically related to Capacity Building, given its importance for the success of the project. UN Open GIS will be based on some existing open source geospatial software (packages and libraries) with many extensions specifically developed. The users of the platform will be the UN staff supporting with mapping and GIS the peacekeeping missions. Therefore, they are generally expert of this specific domain, even if they are currently using proprietary software. UN Open GIS Capacity Building is specifically thought for covering this gap, providing them the suitable background about open source geospatial software in general and the education tailored to the solution that has been being developed within the project itself.

  6. OpenADR Open Source Toolkit: Developing Open Source Software for the Smart Grid

    Energy Technology Data Exchange (ETDEWEB)

    McParland, Charles

    2011-02-01

    Demand response (DR) is becoming an increasingly important part of power grid planning and operation. The advent of the Smart Grid, which mandates its use, further motivates selection and development of suitable software protocols to enable DR functionality. The OpenADR protocol has been developed and is being standardized to serve this goal. We believe that the development of a distributable, open source implementation of OpenADR will benefit this effort and motivate critical evaluation of its capabilities, by the wider community, for providing wide-scale DR services

  7. HIF-1 α had pivotal effects on downregulation of miR-210 decreasing viability and inducing apoptosis in hypoxic chondrocytes.

    Science.gov (United States)

    Chang, Zhiqiang; Huo, Lifeng; Wu, Yimin; Zhang, Pei

    2014-01-01

    Hypoxia-inducible factor 1-alpha (HIF-1 α ) and some microRNA (miRNAs) play pivotal roles in response to hypoxia-related physiologic and pathophysiologic responses. Up to date, the regulatory mechanisms of these molecules were largely unknown in chondrocytes. In this study, to study the mechanisms of degradation and homeostasis of chondrocytes, the effects of miRNAs and HIF-1 α on chondrocytes in physiologic environment were investigated. We found that the overexpression of miR-210 and HIF-1 α was present on hypoxia in C28/I2 human chondrocytes significantly by qRT-PCR and western plot. Further study displayed that miR-210 played positive role as a promoter in regulation and its regulated molecules (bcl-xl and PHD-2) in C28/I2 cells on hypoxia by silenced miR-210, silenced HIF-1 α , and adding miR-210. Moreover, downregulated miR-210 could significantly repress the viability and increase the apoptosis in C28/I2 cells on hypoxia, compared to those on normoxia. Furthermore, miR-210 could not modulate viability and apoptosis in C28/I2 cells with the HIF-1 α knockdown on hypoxia and normoxia. Taken together, this study demonstrated that the MiR-210 was involved in an HIF-1 α -dependent way in C28/I2 human chondrocytes for the first time. It also suggested that miR-210 downregulation decreased viability and induced apoptosis in hypoxic chondrocytes depending on HIF-1 α .

  8. HIF-1α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes

    Directory of Open Access Journals (Sweden)

    Zhiqiang Chang

    2014-01-01

    Full Text Available Hypoxia-inducible factor 1-alpha (HIF-1α and some microRNA (miRNAs play pivotal roles in response to hypoxia-related physiologic and pathophysiologic responses. Up to date, the regulatory mechanisms of these molecules were largely unknown in chondrocytes. In this study, to study the mechanisms of degradation and homeostasis of chondrocytes, the effects of miRNAs and HIF-1α on chondrocytes in physiologic environment were investigated. We found that the overexpression of miR-210 and HIF-1α was present on hypoxia in C28/I2 human chondrocytes significantly by qRT-PCR and western plot. Further study displayed that miR-210 played positive role as a promoter in regulation and its regulated molecules (bcl-xl and PHD-2 in C28/I2 cells on hypoxia by silenced miR-210, silenced HIF-1α, and adding miR-210. Moreover, downregulated miR-210 could significantly repress the viability and increase the apoptosis in C28/I2 cells on hypoxia, compared to those on normoxia. Furthermore, miR-210 could not modulate viability and apoptosis in C28/I2 cells with the HIF-1α knockdown on hypoxia and normoxia. Taken together, this study demonstrated that the MiR-210 was involved in an HIF-1α-dependent way in C28/I2 human chondrocytes for the first time. It also suggested that miR-210 downregulation decreased viability and induced apoptosis in hypoxic chondrocytes depending on HIF-1α.

  9. Pivotal Role for a Tail Subunit of the RNA Polymerase II Mediator Complex CgMed2 in Azole Tolerance and Adherence in Candida glabrata

    Science.gov (United States)

    Borah, Sapan; Shivarathri, Raju; Srivastava, Vivek Kumar; Ferrari, Sélène; Sanglard, Dominique

    2014-01-01

    Antifungal therapy failure can be associated with increased resistance to the employed antifungal agents. Candida glabrata, the second most common cause of invasive candidiasis, is intrinsically less susceptible to the azole class of antifungals and accounts for 15% of all Candida bloodstream infections. Here, we show that C. glabrata MED2 (CgMED2), which codes for a tail subunit of the RNA polymerase II Mediator complex, is required for resistance to azole antifungal drugs in C. glabrata. An inability to transcriptionally activate genes encoding a zinc finger transcriptional factor, CgPdr1, and multidrug efflux pump, CgCdr1, primarily contributes to the elevated susceptibility of the Cgmed2Δ mutant toward azole antifungals. We also report for the first time that the Cgmed2Δ mutant exhibits sensitivity to caspofungin, a constitutively activated protein kinase C-mediated cell wall integrity pathway, and elevated adherence to epithelial cells. The increased adherence of the Cgmed2Δ mutant was attributed to the elevated expression of the EPA1 and EPA7 genes. Further, our data demonstrate that CgMED2 is required for intracellular proliferation in human macrophages and modulates survival in a murine model of disseminated candidiasis. Lastly, we show an essential requirement for CgMed2, along with the Mediator middle subunit CgNut1 and the Mediator cyclin-dependent kinase/cyclin subunit CgSrb8, for the high-level fluconazole resistance conferred by the hyperactive allele of CgPdr1. Together, our findings underscore a pivotal role for CgMed2 in basal tolerance and acquired resistance to azole antifungals. PMID:25070095

  10. Cognitive decline and reorganization of functional connectivity in healthy aging: the pivotal role of the salience network in the prediction of age and cognitive performances

    Directory of Open Access Journals (Sweden)

    Valentina La Corte

    2016-08-01

    Full Text Available Normal aging is related to a decline in specific cognitive processes, in particular in executive functions and memory. In recent years a growing number of studies have focused on changes in brain functional connectivity related to cognitive aging. A common finding is the decreased connectivity within multiple resting state networks, including the default mode network and the salience network. In this study, we measured resting state activity using fMRI and explored whether cognitive decline is related to altered functional connectivity. To this end we used a machine learning approach to classify young and old participants from functional connectivity data. The originality of the approach consists in the prediction of the performance and age of the subjects based on functional connectivity. Our findings showed that the connectivity profile between specific networks predicts both the age of the subjects and their cognitive abilities. In particular, we report that the connectivity profiles between the salience and visual networks, and the salience and the anterior part of the default mode network, were the features that best predicted the age. Moreover, independently of the age of the subject, connectivity between the salience network and various specific networks (i.e., visual, frontal predicted episodic memory skills either based on a standard assessment or on an autobiographical memory task, and short-term binding.Finally, the connectivity between the salience and the frontal networks predicted inhibition and updating performance, but this link was no longer significant after removing the effect of age. Our findings confirm the crucial role of episodic memory and executive functions in cognitive aging and suggest a pivotal role of the salience network in neural reorganization in aging.

  11. Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.

    Science.gov (United States)

    Al Ghouleh, Imad; Meijles, Daniel N; Mutchler, Stephanie; Zhang, Qiangmin; Sahoo, Sanghamitra; Gorelova, Anastasia; Henrich Amaral, Jefferson; Rodríguez, Andrés I; Mamonova, Tatyana; Song, Gyun Jee; Bisello, Alessandro; Friedman, Peter A; Cifuentes-Pagano, M Eugenia; Pagano, Patrick J

    2016-09-06

    Despite numerous reports implicating NADPH oxidases (Nox) in the pathogenesis of many diseases, precise regulation of this family of professional reactive oxygen species (ROS) producers remains unclear. A unique member of this family, Nox1 oxidase, functions as either a canonical or hybrid system using Nox organizing subunit 1 (NoxO1) or p47(phox), respectively, the latter of which is functional in vascular smooth muscle cells (VSMC). In this manuscript, we identify critical requirement of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50; aka NHERF1) for Nox1 activation and downstream responses. Superoxide (O2 (•-)) production induced by angiotensin II (AngII) was absent in mouse EBP50 KO VSMC vs. WT. Moreover, ex vivo incubation of aortas with AngII showed a significant increase in O2 (•-) in WT but not EBP50 or Nox1 nulls. Similarly, lipopolysaccharide (LPS)-induced oxidative stress was attenuated in femoral arteries from EBP50 KO vs. WT. In silico analyses confirmed by confocal microscopy, immunoprecipitation, proximity ligation assay, FRET, and gain-/loss-of-function mutagenesis revealed binding of EBP50, via its PDZ domains, to a specific motif in p47(phox) Functional studies revealed AngII-induced hypertrophy was absent in EBP50 KOs, and in VSMC overexpressing EBP50, Nox1 gene silencing abolished VSMC hypertrophy. Finally, ex vivo measurement of lumen diameter in mouse resistance arteries exhibited attenuated AngII-induced vasoconstriction in EBP50 KO vs. WT. Taken together, our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes.

  12. Toxic and genotoxic effects of the imazethapyr-based herbicide formulation Pivot H® on montevideo tree frog Hypsiboas pulchellus tadpoles (Anura, Hylidae).

    Science.gov (United States)

    Pérez-Iglesias, J M; Soloneski, S; Nikoloff, N; Natale, G S; Larramendy, M L

    2015-09-01

    Acute lethal and sublethal toxicity of the imidazolinone imazethapyr (IMZT)-based commercial formulation herbicide Pivot H® (10.59% IMZT) was evaluated on Hypsiboas pulchellus tadpoles. Whereas mortality was used as the end point for lethality, frequency of micronuclei (MNs) and other nuclear abnormalities as well as DNA single-strand breaks evaluated by the single cell gel electrophoresis assay were employed to test genotoxicity. Behavioral, growth, developmental, and morphological abnormalities were also employed as sublethal end points. Mortality studies revealed equivalent LC50 (96h) values of 1.49mg/L (confidence limit, 1.09-1.63) and 1.55mg/L (confidence limit, 1.51-1.60) IMZT for Gosner stage (GS) 25 and GS36, respectively. Behavioral changes, i.e., irregular swimming and immobility, as well as a decreased frequency of keratodonts were observed. The herbicide increased the frequency of MNs in circulating erythrocytes of tadpoles exposed for 48h to the highest concentration assayed (1.17mg/L). However, regardless of the concentration of the herbicide assayed, an enhanced frequency of MNs was observed in tadpoles exposed for 96h. The herbicide was able to induce other nuclear abnormalities, i.e., blebbed and notched nuclei, only when tadpoles were exposed for 96h. In addition, we observed that exposure to IMZT within the 0.39-1.17mg/L range increased the genetic damage index in treatments lasting for both 48 and 96h. This study represents the first evidence of acute lethal and sublethal effects exerted by IMZT on amphibians. Finally, our findings highlight the properties of this herbicide that jeopardize nontarget living species exposed to IMZT.

  13. Qualidade da irrigação controlada por tensiômetros em pivô central Quality of center pivot irrigation controlled by tensiometers

    Directory of Open Access Journals (Sweden)

    A.M. Saad

    1994-12-01

    Full Text Available A qualidade da irrigação foi avaliada durante a safra de inverno do ano de 1988 na cultura do feijoeiro (Phaseolus vulgaris L., irrigado por pivô central, em área de ocorrência de Latossolo Roxo (A moderado, textura argilosa a muito argilosa, distrófico, em Guaíra, SP. Os critérios utilizados para esta avaliação foram a eficiência do uso da água pela cultura e a efetividade da irrigação, esta última representada pela eficiência de aplicação da água, a uniformidade de distribuição da água sobre o solo e a eficiência de armazenagem da água no solo. O monitoramento das irrigações foi realizado através da instalação de 20 baterias de tensiômetros e 60 coletores de água de chuva e irrigação ao longo de uma transeção de 300 metros na direção radial do pivô. Os tensiômetros de cada bateria foram instalados a 15 cm e 30 cm de profundidade e espaçados entre si de 15 metros. Os coletores foram instalados a uma altura de 50 cm da superfície do terreno e distanciados entre si de 5 metros. O controle da irrigação foi feito com base na média ponderada dos 20 valores diários de potencial mátrico a 15 cm de profundidade, tendo como fator de ponderação a área representativa de cada tensiômetro. O valor mínimo de potencial mátrico estabelecido para a definição do momento da irrigação foi -0,06 MPa à profundidade de 15 cm e o valor da lâmina de água a ser aplicada em cada irrigação, calculado tendo-se em conta o valor de -0,008 MPa para o potencial mátrico a capacidade de campo. Os resultados obtidos mostraram que as irrigações efetuadas foram de alta qualidade uma vez que foram elevados os valores da eficiência de aplicação (80% e dos coeficientes de uniformidade de distribuição (94 e 91% calculados a partir das 16 irrigações acumuladas, o mesmo ocorrendo com a eficiência de armazenagem (95% e a eficiência de uso da água (0,8 kg/m³.The irrigation quality was evaluated for a center pivot

  14. Open DOAR the Directory of Open Access Repositories

    CERN Document Server

    CERN. Geneva

    2005-01-01

    The last year has seen wide-spread growth in the idea of using open access repositories as a part of a research institution's accepted infrastructure. Policy development from institutions and funding bodies has also supported the growth of the repository network. The next stage of expansion will be in the provision of services and cross-repository facilities and resources. Of course, it is hoped that these will then establish a feed-back loop to encourage repository population and further repository establishment, as the potential of open access to research materials is realised. The growth of repositories has been organic, with a variety of different repositories based in departments, institutions, funding agencies or subject communities, with a range of content, both in type and subject. Existing repositories are expanding their holdings, from eprints to associated research data-sets, or with learning objects and multimedia material. This presentation will look at the development of the Directory of Open Ac...

  15. Open source intelligence, open social intelligence and privacy by design

    OpenAIRE

    Casanovas, Pompeu; Royal Melbourne Institute of Technology (Austràlia). Centre for Applied Social Research

    2014-01-01

    Ponència presentada a European Conference on Social Intelligence (ECSI-2014) OSINT stands for Open Source Intelligence, (O)SI for (Open) Social Intelligence, PbD for Privacy by Design. The CAPER project has built an OSINT solution oriented to the prevention of organized crime. How to balance freedom and security? This position paper describes a way to embed the legal and ethical issues raised by the General Data Reform Package (GDRP) in Europe into this kind of surveillance platforms. It f...

  16. Parâmetros de desempenho de dezesseis equipamentos de irrigação por pivô central Parameters of performance of sixteen center-pivot irrigation equipments

    Directory of Open Access Journals (Sweden)

    Delvio Sandri

    2009-02-01

    Full Text Available O tempo de uso de sistemas de irrigação por pivô central pode resultar em alteração de suas características hidráulicas, necessitando de avaliações periódicas para manter a uniformidade de distribuição de água em níveis aceitáveis. Objetivou-se, neste trabalho, avaliar as condições de funcionamento e desempenho de dezesseis pivôs centrais, localizados em onze municípios de Goiás e no Distrito Federal. Estimou-se o coeficiente de uniformidade de Heermann & Hein - CUH e uniformidade de distribuição - CUD, variação da lâmina coletada em relação à projetada e os fatores que interferem no desempenho dos equipamentos. Dos pivôs avaliados, quatro (25% apresentaram CUH inadequado (The time of use of the center-pivot irrigation system may result in alteration of the hydraulic characteristics, frequent evaluations being needed to maintain the efficiency of water distribution at acceptable levels. The aim of this work was to evaluate the conditions of the use and the performance of sixteen center pivots, located in eleven municipal districts of Goiás State and Federal District, Brazil. The Heermann & Hein - CUH coefficient of uniformity and coefficient of distribution - CUD, variation between the collected and projected depth and verification of the main factors that influenced the performance were evaluated. Among the evaluated pivots, four (25% presented inadequate CUH (< 80% and three (18.75% presented inadequate CUD (< 70%. The average depth applied was higher than the projected in three and lower in thirteen pivots, with the difference higher than 10% in only one pivot. Most of the evaluated pivots need maintenance to solve the following problems: emitters with flow rate different from the flow considered appropriate for some intervals of the equipments; emitters totally or partially clogged or damaged; absence of suspension strings; damaged pressure regulators; leaks in several points and speed displacement different

  17. Controls on open water evaporation

    Directory of Open Access Journals (Sweden)

    R. J. Granger

    2010-05-01

    Full Text Available The paper presents the initial results of a field study of boundary layer behaviour and open water evaporation carried out on two small- to medium-sized lakes in Western and Northern Canada. Meteorological and boundary layer measurements were made over the water surfaces and over the upwind land surface, allowing for an examination of the effect of lake-land contrasts of temperature on the wind speed over the open water and on the evaporation rates. Lake evaporation was measured directly using eddy covariance equipment.

    The study showed that, for time periods shorter than daily, the open water evaporation bears no relationship to the net radiation. The wind speed is the most significant factor governing the evaporation rates, followed by the land-water temperature contrast and the land-water vapour pressure contrast. The effect of the stability on the wind field is demonstrated; stability over the water and adjacent land surfaces are, for the most part, out of phase. The derived relationships will be used to develop a model for estimating the hourly evaporation rates from open water.

    Examination of the seasonal trends shows that the open water period can be separated into two distinct evaporative regimes: the warming period in the Spring, when the land temperature is greater than the water temperature, the turbulent fluxes over water are suppressed; and the cooling period, when the water temperature is greater than the air temperature, and the turbulent fluxes over water are enhanced.

  18. Hypothesis Formation, Paradigms, and Openness

    Directory of Open Access Journals (Sweden)

    Conrad P. Pritscher

    2008-01-01

    Full Text Available A part of hypothesis formation, while necessary for scientific investigation, is beyond direct observation. Powerful hypothesis formation is more than logical and is facilitated by mind­opening. As Percy Bridgeman, Nobel laureate, said, science is: “Nothing more than doing one's damnedest with one's mind, no holds barred.” This paper suggests more open schooling helps generate more open hypothesizing which helps one do one's damnedest with one's mind. It is hypothesized that a more open process of hypothesis formation may help schools and society forge new ways of living and learning so that more people more often can do their damnedest with their mind. This writing does not offer a new paradigm but rather attempts to elaborate on the notion that new paradigms are difficult to form without openness to what was previously quasi­unthinkable. More on these topics and issues is included in the author's Reopening Einstein's Thought: About What Can't Be Learned From Textbooks ­­to be published by Sense Publishers in June 2008.

  19. Open Government Data: Fostering Innovation

    Directory of Open Access Journals (Sweden)

    Ivan Bedini

    2014-11-01

    Full Text Available The provision of public information contributes to the enrichment and enhancement of the data produced by the government as part of its activities, and the transformation of heterogeneous data into information and knowledge. This process of opening changes the operational mode of public administrations, leveraging the data management, encouraging savings and especially in promoting the development of services in subsidiary and collaborative form between public and private entities. The demand for new services also promotes renewed entrepreneurship centred on responding to new social and territorial needs through new technologies. In this sense we speak of Open Data as an enabling infrastructure for the development of innovation and as an instrument to the development and diffusion of Innovation and Communications Technology (ICT in the public system as well as creating space for innovation for businesses, particularly SMEs, based on the exploitation of information assets of the territory. The Open Data Trentino Project has initiated and fosters the process of opening of public information and develops as a natural consequence of this process of openness, the creation of innovative services for and with the citizens. In this paper we present how our project acts on long-chain, from raw data till reusable meaningful and scalable knowledge base that leads to the production of data reuse through the implementation of services that will enhance and transform the data into information capable of responding to specific questions efficiency and innovation.

  20. Facilitating lifelong learning with OpenU

    NARCIS (Netherlands)

    Rubens, Wilfred; Counotte, Anda

    2012-01-01

    Rubens, W., & Counotte, A. (2012). Facilitating lifelong learning with OpenU. In R. Jacobi, & N. van der Woert (Eds.), Trendreport Open Educational Resources 2012 (pp. 22-26). Utrecht: SURF Foundation - Special Interest Group Open Educational Resources SURF.