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Sample records for op cumulative risk

  1. EPA Workshop on Epigenetics and Cumulative Risk ...

    Science.gov (United States)

    Agenda Download the Workshop Agenda (PDF) The workshop included presentations and discussions by scientific experts pertaining to three topics (i.e., epigenetic changes associated with diverse stressors, key science considerations in understanding epigenetic changes, and practical application of epigenetic tools to address cumulative risks from environmental stressors), to address several questions under each topic, and included an opportunity for attendees to participate in break-out groups, provide comments and ask questions. Workshop Goals The workshop seeks to examine the opportunity for use of aggregate epigenetic change as an indicator in cumulative risk assessment for populations exposed to multiple stressors that affect epigenetic status. Epigenetic changes are specific molecular changes around DNA that alter expression of genes. Epigenetic changes include DNA methylation, formation of histone adducts, and changes in micro RNAs. Research today indicates that epigenetic changes are involved in many chronic diseases (cancer, cardiovascular disease, obesity, diabetes, mental health disorders, and asthma). Research has also linked a wide range of stressors including pollution and social factors with occurrence of epigenetic alterations. Epigenetic changes have the potential to reflect impacts of risk factors across multiple stages of life. Only recently receiving attention is the nexus between the factors of cumulative exposure to environmental

  2. Cumulative risks of foster care placement for Danish children

    National Research Council Canada - National Science Library

    Fallesen, Peter; Emanuel, Natalia; Wildeman, Christopher

    2014-01-01

    Although recent research suggests that the cumulative risk of foster care placement is far higher for American children than originally suspected, little is known about the cumulative risk of foster...

  3. Cumulative Risks of Foster Care Placement for Danish Children

    DEFF Research Database (Denmark)

    Fallesen, Peter; Emanuel, Natalia; Wildeman, Christopher

    2014-01-01

    Although recent research suggests that the cumulative risk of foster care placement is far higher for American children than originally suspected, little is known about the cumulative risk of foster care placement in other countries, which makes it difficult to gauge the degree to which factor...... is for Danish children. Results suggest that at the beginning of the study period (in 1998) the cumulative risk of foster care placement for Danish children was roughly in line with the risk for American children. Yet, by the end of the study period (2010), the risk had declined to half the risk for American...... foster care placement is salient in other contexts. In this article, we provide companion estimates to those provided in recent work on the US by using Danish registry data and synthetic cohort life tables to show how high and unequally distributed the cumulative risk of foster care placement...

  4. Childhood Cumulative Risk Exposure and Adult Amygdala Volume and Function.

    Science.gov (United States)

    Evans, Gary W; Swain, James E; King, Anthony P; Wang, Xin; Javanbakht, Arash; Ho, S Shaun; Angstadt, Michael; Phan, K Luan; Xie, Hong; Liberzon, Israel

    2016-06-01

    Considerable work indicates that early cumulative risk exposure is aversive to human development, but very little research has examined the neurological underpinnings of these robust findings. This study investigates amygdala volume and reactivity to facial stimuli among adults (mean 23.7 years of age, n = 54) as a function of cumulative risk exposure during childhood (9 and 13 years of age). In addition, we test to determine whether expected cumulative risk elevations in amygdala volume would mediate functional reactivity of the amygdala during socioemotional processing. Risks included substandard housing quality, noise, crowding, family turmoil, child separation from family, and violence. Total and left hemisphere adult amygdala volumes were positively related to cumulative risk exposure during childhood. The links between childhood cumulative risk exposure and elevated amygdala responses to emotionally neutral facial stimuli in adulthood were mediated by the corresponding amygdala volumes. Cumulative risk exposure in later adolescence (17 years of age), however, was unrelated to subsequent adult amygdala volume or function. Physical and socioemotional risk exposures early in life appear to alter amygdala development, rendering adults more reactive to ambiguous stimuli such as neutral faces. These stress-related differences in childhood amygdala development might contribute to the well-documented psychological distress as a function of early risk exposure.

  5. Cumulative risks of foster care placement for Danish children.

    Science.gov (United States)

    Fallesen, Peter; Emanuel, Natalia; Wildeman, Christopher

    2014-01-01

    Although recent research suggests that the cumulative risk of foster care placement is far higher for American children than originally suspected, little is known about the cumulative risk of foster care placement in other countries, which makes it difficult to gauge the degree to which factor foster care placement is salient in other contexts. In this article, we provide companion estimates to those provided in recent work on the US by using Danish registry data and synthetic cohort life tables to show how high and unequally distributed the cumulative risk of foster care placement is for Danish children. Results suggest that at the beginning of the study period (in 1998) the cumulative risk of foster care placement for Danish children was roughly in line with the risk for American children. Yet, by the end of the study period (2010), the risk had declined to half the risk for American children. Our results also show some variations by parental ethnicity and sex, but these differences are small. Indeed, they appear quite muted relative to racial/ethnic differences in these risks in the United States. Last, though cumulative risks are similar between Danish and American children (especially at the beginning of the study period), the age-specific risk profiles are markedly different, with higher risks for older Danish children than for older American children.

  6. Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

    Directory of Open Access Journals (Sweden)

    Jonathan I. Levy

    2012-05-01

    Full Text Available Cumulative risk assessment has been proposed as an approach to evaluate the health risks associated with simultaneous exposure to multiple chemical and non-chemical stressors. Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD models can allow for the inclusion and evaluation of multiple stressors, including non-chemical stressors, but studies have not leveraged PBPK/PD models to jointly consider these disparate exposures in a cumulative risk context. In this study, we focused on exposures to organophosphate (OP pesticides for children in urban low-income environments, where these children would be simultaneously exposed to other pesticides (including pyrethroids and non-chemical stressors that may modify the effects of these exposures (including diet. We developed a methodological framework to evaluate chemical and non-chemical stressor impacts on OPs, utilizing an existing PBPK/PD model for chlorpyrifos. We evaluated population-specific stressors that would influence OP doses or acetylcholinesterase (AChE inhibition, the relevant PD outcome. We incorporated the impact of simultaneous exposure to pyrethroids and dietary factors on OP dose through the compartments of metabolism and PD outcome within the PBPK model, and simulated combinations of stressors across multiple exposure ranges and potential body weights. Our analyses demonstrated that both chemical and non-chemical stressors can influence the health implications of OP exposures, with up to 5-fold variability in AChE inhibition across combinations of stressor values for a given OP dose. We demonstrate an approach for modeling OP risks in the presence of other population-specific environmental stressors, providing insight about co-exposures and variability factors that most impact OP health risks and contribute to children’s cumulative health risk from pesticides. More generally, this framework can be used to inform cumulative risk assessment for any compound impacted by

  7. Cumulative Effect of Depression on Dementia Risk

    Directory of Open Access Journals (Sweden)

    J. Olazarán

    2013-01-01

    Full Text Available Objective. To analyze a potential cumulative effect of life-time depression on dementia and Alzheimer’s disease (AD, with control of vascular factors (VFs. Methods. This study was a subanalysis of the Neurological Disorders in Central Spain (NEDICES study. Past and present depression, VFs, dementia status, and dementia due to AD were documented at study inception. Dementia status was also documented after three years. Four groups were created according to baseline data: never depression (nD, past depression (pD, present depression (prD, and present and past depression (prpD. Logistic regression was used. Results. Data of 1,807 subjects were investigated at baseline (mean age 74.3, 59.3% women, and 1,376 (81.6% subjects were evaluated after three years. The prevalence of dementia at baseline was 6.7%, and dementia incidence was 6.3%. An effect of depression was observed on dementia prevalence (OR [CI 95%] 1.84 [1.01–3.35] for prD and 2.73 [1.08–6.87] for prpD, and on dementia due to AD (OR 1.98 [0.98–3.99] for prD and OR 3.98 [1.48–10.71] for prpD (fully adjusted models, nD as reference. Depression did not influence dementia incidence. Conclusions. Present depression and, particularly, present and past depression are associated with dementia at old age. Multiple mechanisms, including toxic effect of depression on hippocampal neurons, plausibly explain these associations.

  8. Cumulative risk hypothesis: Predicting and preventing child maltreatment recidivism.

    Science.gov (United States)

    Solomon, David; Åsberg, Kia; Peer, Samuel; Prince, Gwendolyn

    2016-08-01

    Although Child Protective Services (CPS) and other child welfare agencies aim to prevent further maltreatment in cases of child abuse and neglect, recidivism is common. Having a better understanding of recidivism predictors could aid in preventing additional instances of maltreatment. A previous study identified two CPS interventions that predicted recidivism: psychotherapy for the parent, which was related to a reduced risk of recidivism, and temporary removal of the child from the parent's custody, which was related to an increased recidivism risk. However, counter to expectations, this previous study did not identify any other specific risk factors related to maltreatment recidivism. For the current study, it was hypothesized that (a) cumulative risk (i.e., the total number of risk factors) would significantly predict maltreatment recidivism above and beyond intervention variables in a sample of CPS case files and that (b) therapy for the parent would be related to a reduced likelihood of recidivism. Because it was believed that the relation between temporary removal of a child from the parent's custody and maltreatment recidivism is explained by cumulative risk, the study also hypothesized that that the relation between temporary removal of the child from the parent's custody and recidivism would be mediated by cumulative risk. After performing a hierarchical logistic regression analysis, the first two hypotheses were supported, and an additional predictor, psychotherapy for the child, also was related to reduced chances of recidivism. However, Hypothesis 3 was not supported, as risk did not significantly mediate the relation between temporary removal and recidivism.

  9. The proportional odds cumulative incidence model for competing risks

    DEFF Research Database (Denmark)

    Eriksson, Frank; Li, Jianing; Scheike, Thomas

    2015-01-01

    We suggest an estimator for the proportional odds cumulative incidence model for competing risks data. The key advantage of this model is that the regression parameters have the simple and useful odds ratio interpretation. The model has been considered by many authors, but it is rarely used in pr...

  10. Cumulative Risk Assessment Toolbox: Methods and Approaches for the Practitioner

    Directory of Open Access Journals (Sweden)

    Margaret M. MacDonell

    2013-01-01

    Full Text Available The historical approach to assessing health risks of environmental chemicals has been to evaluate them one at a time. In fact, we are exposed every day to a wide variety of chemicals and are increasingly aware of potential health implications. Although considerable progress has been made in the science underlying risk assessments for real-world exposures, implementation has lagged because many practitioners are unaware of methods and tools available to support these analyses. To address this issue, the US Environmental Protection Agency developed a toolbox of cumulative risk resources for contaminated sites, as part of a resource document that was published in 2007. This paper highlights information for nearly 80 resources from the toolbox and provides selected updates, with practical notes for cumulative risk applications. Resources are organized according to the main elements of the assessment process: (1 planning, scoping, and problem formulation; (2 environmental fate and transport; (3 exposure analysis extending to human factors; (4 toxicity analysis; and (5 risk and uncertainty characterization, including presentation of results. In addition to providing online access, plans for the toolbox include addressing nonchemical stressors and applications beyond contaminated sites and further strengthening resource accessibility to support evolving analyses for cumulative risk and sustainable communities.

  11. Cumulative Risk Assessment Toolbox: Methods and Approaches for the Practitioner

    Science.gov (United States)

    MacDonell, Margaret M.; Haroun, Lynne A.; Teuschler, Linda K.; Rice, Glenn E.; Hertzberg, Richard C.; Butler, James P.; Chang, Young-Soo; Clark, Shanna L.; Johns, Alan P.; Perry, Camarie S.; Garcia, Shannon S.; Jacobi, John H.; Scofield, Marcienne A.

    2013-01-01

    The historical approach to assessing health risks of environmental chemicals has been to evaluate them one at a time. In fact, we are exposed every day to a wide variety of chemicals and are increasingly aware of potential health implications. Although considerable progress has been made in the science underlying risk assessments for real-world exposures, implementation has lagged because many practitioners are unaware of methods and tools available to support these analyses. To address this issue, the US Environmental Protection Agency developed a toolbox of cumulative risk resources for contaminated sites, as part of a resource document that was published in 2007. This paper highlights information for nearly 80 resources from the toolbox and provides selected updates, with practical notes for cumulative risk applications. Resources are organized according to the main elements of the assessment process: (1) planning, scoping, and problem formulation; (2) environmental fate and transport; (3) exposure analysis extending to human factors; (4) toxicity analysis; and (5) risk and uncertainty characterization, including presentation of results. In addition to providing online access, plans for the toolbox include addressing nonchemical stressors and applications beyond contaminated sites and further strengthening resource accessibility to support evolving analyses for cumulative risk and sustainable communities. PMID:23762048

  12. Cumulative risk: toxicity and interactions of physical and chemical stressors.

    Science.gov (United States)

    Rider, Cynthia V; Boekelheide, Kim; Catlin, Natasha; Gordon, Christopher J; Morata, Thais; Selgrade, Maryjane K; Sexton, Kenneth; Simmons, Jane Ellen

    2014-01-01

    Recent efforts to update cumulative risk assessment procedures to incorporate nonchemical stressors ranging from physical to psychosocial reflect increased interest in consideration of the totality of variables affecting human health and the growing desire to develop community-based risk assessment methods. A key roadblock is the uncertainty as to how nonchemical stressors behave in relationship to chemical stressors. Physical stressors offer a reasonable starting place for measuring the effects of nonchemical stressors and their modulation of chemical effects (and vice versa), as they clearly differ from chemical stressors; and "doses" of many physical stressors are more easily quantifiable than those of psychosocial stressors. There is a commonly held belief that virtually nothing is known about the impact of nonchemical stressors on chemically mediated toxicity or the joint impact of coexposure to chemical and nonchemical stressors. Although this is generally true, there are several instances where a substantial body of evidence exists. A workshop titled "Cumulative Risk: Toxicity and Interactions of Physical and Chemical Stressors" held at the 2013 Society of Toxicology Annual Meeting provided a forum for discussion of research addressing the toxicity of physical stressors and what is known about their interactions with chemical stressors, both in terms of exposure and effects. Physical stressors including sunlight, heat, radiation, infectious disease, and noise were discussed in reference to identifying pathways of interaction with chemical stressors, data gaps, and suggestions for future incorporation into cumulative risk assessments.

  13. Childhood poverty and health: cumulative risk exposure and stress dysregulation.

    Science.gov (United States)

    Evans, Gary W; Kim, Pilyoung

    2007-11-01

    A massive literature documents the inverse association between poverty or low socioeconomic status and health, but little is known about the mechanisms underlying this robust relation. We examined longitudinal relations between duration of poverty exposure since birth, cumulative risk exposure, and physiological stress in two hundred seven 13-year-olds. Chronic stress was assessed by basal blood pressure and overnight cortisol levels; stress regulation was assessed by cardiovascular reactivity to a standard acute stressor and recovery after exposure to this stressor. Cumulative risk exposure was measured by multiple physical (e.g., substandard housing) and social (e.g., family turmoil) risk factors. The greater the number of years spent living in poverty, the more elevated was overnight cortisol and the more dysregulated was the cardiovascular response (i.e., muted reactivity). Cardiovascular recovery was not affected by duration of poverty exposure. Unlike the duration of poverty exposure, concurrent poverty (i.e., during adolescence) did not affect these physiological stress outcomes. The effects of childhood poverty on stress dysregulation are largely explained by cumulative risk exposure accompanying childhood poverty.

  14. The cumulative effect of risk compensation on infection preventive measures.

    Science.gov (United States)

    Maxin, Daniel; Sega, Laurentiu; Eaton, Lisa

    2016-12-01

    We study several epidemic models (with and without gender structure) that incorporate risk compensation behavior in response to a lower chance of acquiring the infection as a result of preventive measures that are only partially effective. We show that the cumulative risk compensation that occurs between a high risk susceptible and infectious individual may play an important role in whether the implementation of these measures is successful in lowering the epidemic reproductive number. In addition, we show that certain levels of risk compensation may cancel the benefit of the low infection risk practiced by diagnosed infectious individuals when the goal is a reduction of the epidemic reproductive number. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Use of a Cumulative Risk Scale to Predict Poor Intellectual and Academic Outcomes in Childhood Epilepsy.

    Science.gov (United States)

    Kavanaugh, Brian C; Scarborough, Vanessa Ramos; Salorio, Cynthia F

    2016-06-01

    Discrete risk factors for poor outcomes in childhood epilepsy have been identified, but it is unclear whether the combined effect of several risk factors better predicts outcome. The Epilepsy Cumulative Risk Scale was developed to quantify cumulative risk for poor outcomes in childhood epilepsy. Participants included 156 clinic-referred children with epilepsy. The Epilepsy Cumulative Risk Scale was developed using variables previously associated with functional outcomes. Scale utility was examined through its association with intellectual and academic functioning. All Epilepsy Cumulative Risk Scale variables were significantly associated with functioning. The Total Score (ie, cumulative effect) was most strongly correlated with cognition and academic skills. A Total Score ≥ 5 had the best sensitivity and specificity for differentiating those at high risk for poor outcomes. The Epilepsy Cumulative Risk Scale shows promise as a practical, data-driven tool for quantification of cumulative risk for poor outcomes in childhood epilepsy and may be helpful in detecting those needing referral for additional services.

  16. 75 FR 69662 - Workshop: Cumulative Mixtures Risk of Six Selected Phthalates in Support of Summary Information...

    Science.gov (United States)

    2010-11-15

    ... AGENCY Workshop: Cumulative Mixtures Risk of Six Selected Phthalates in Support of Summary Information on...: Notice of Peer Consultation Workshop on the Cumulative Mixtures Risk of Six Selected Phthalates; Request... phthalates as set forth in the National Academies of Science (NAS) report ``Phthalates and Cumulative...

  17. Cumulative Incidence Association Models for Bivariate Competing Risks Data.

    Science.gov (United States)

    Cheng, Yu; Fine, Jason P

    2012-03-01

    Association models, like frailty and copula models, are frequently used to analyze clustered survival data and evaluate within-cluster associations. The assumption of noninformative censoring is commonly applied to these models, though it may not be true in many situations. In this paper, we consider bivariate competing risk data and focus on association models specified for the bivariate cumulative incidence function (CIF), a nonparametrically identifiable quantity. Copula models are proposed which relate the bivariate CIF to its corresponding univariate CIFs, similarly to independently right censored data, and accommodate frailty models for the bivariate CIF. Two estimating equations are developed to estimate the association parameter, permitting the univariate CIFs to be estimated either parametrically or nonparametrically. Goodness-of-fit tests are presented for formally evaluating the parametric models. Both estimators perform well with moderate sample sizes in simulation studies. The practical use of the methodology is illustrated in an analysis of dementia associations.

  18. The effects of antipoverty programs on children's cumulative level of poverty-related risk.

    Science.gov (United States)

    Gassman-Pines, Anna; Yoshikawa, Hirokazu

    2006-11-01

    The authors examined the effects of antipoverty programs on children's cumulative poverty-related risk and the relationship between cumulative poverty-related risk and child outcomes among low-income families. Samples included 419 children ages 3-10 years in the New Hope program and 759 children ages 2-9 years in the Minnesota Family Investment Program (MFIP), which tested 2 program approaches. Nine poverty-related risks made up the measure of cumulative risk. Both MFIP program approaches reduced cumulative poverty-related risk. New Hope reduced cumulative poverty-related risk among long-term welfare recipients. In both New Hope and MFIP, significant linear relationships between cumulative poverty-related risk and parent-reported behavior problems and school achievement were found. Cumulative poverty-related risk partially mediated the impacts of the MFIP programs on children's behavior problems. Among long-term welfare recipients, cumulative poverty-related risk partially mediated New Hope's impact on parent-reported school achievement.

  19. Probabilistic acute risk assessment of cumulative exposure to organophosphorus and carbamate pesticides from dietary vegetables and fruits in Shanghai populations.

    Science.gov (United States)

    Li, Fan; Yuan, Yaqun; Meng, Pai; Wu, Min; Li, Shuguang; Chen, Bo

    2017-05-01

    Organophosphorus pesticides (OPs) and carbamate pesticides (CPs) are among the most widely used pesticides in China, playing a major role in protecting agricultural commodities. In this study, we determined the cumulative acute exposure to OPs and CPs of Shanghai residents from vegetables and fruits (VFs). The food consumption data were obtained from the Shanghai Food Consumption Survey (SHFCS) of 2012-14 including a total of 1973 participants aged 2-90 years. The pesticide residue data were obtained from the Shanghai monitoring programme during 2008-11 with 34 organophosphates and 11 carbamates analysed in a total of 5335 samples of VFs. A probabilistic approach was performed as recommended by the EFSA, using the optimistic model with non-detects set as zero and with processing factors (PFs) being used and the pessimistic model with non-detects replaced by limit of detection (LOD) and without PFs. We used the relative potency factor (RPF) method to normalise the various pesticides to the index compound (IC) of methamidophos and chlorpyrifos separately. Only in the pessimistic model using methamidophos as the IC was there was small risk of exposure exceeding the ARfD (3 µg kg(-)(1) bw day(-)(1)) in the populations of preschool children (0.029%), school-age children (0.022%) and adults (0.002%). There were no risk of exposure exceeding the ARfD of methamidophos in the optimistic model and of chlorpyrifos (100 µg kg(-)(1) bw day(-)(1)) in both optimistic and pessimistic models in all three populations. Considering the Chinese habits of overwhelmingly eating processed food (vegetables being cooked, and fruits being washed or peeled), we conclude that little acute risk was found for the exposure to VF-sourced OPs and CPs in Shanghai.

  20. Cumulative risk and asthma outcomes in inner-city African-American youth.

    Science.gov (United States)

    Josie, Katherine Leigh; Greenley, Rachel Neff; Drotar, Dennis

    2007-09-01

    A cumulative risk framework was used to examine the impact of the presence of multiple risk factors on key asthma outcomes (i.e., health-related quality of life [HRQoL], severity) for a sample of 149 inner-city African-American youth with asthma. The presence of a greater number of risk factors was associated with lower HRQoL and greater severity, regardless of age or gender. Cumulative risk methodology, in combination with selection of risk factors based on theoretical and empirical work, is a viable option for researchers and clinicians who are interested in examining the impact of multiple risk factors on disease functioning and status.

  1. Low Fruit/Vegetable Consumption in the Home: Cumulative Risk Factors in Early Childhood

    Science.gov (United States)

    Ward, Wendy L.; Swindle, Taren M.; Kyzer, Angela L.; Whiteside-Mansell, Leanne

    2015-01-01

    Cumulative risk theory suggests that a variety of social risk factors would have an additive effect on obesity risk. Multiple studies have suggested that obesity is related to basic resources such as transportation and financial resources. Additional research points to parental engagement and parental monitoring as additional sources of risk. This…

  2. Statistical Methods for Estimating the Cumulative Risk of Screening Mammography Outcomes

    NARCIS (Netherlands)

    Hubbard, R.A.; Ripping, T.M.; Chubak, J.; Broeders, M.J.; Miglioretti, D.L.

    2016-01-01

    BACKGROUND: This study illustrates alternative statistical methods for estimating cumulative risk of screening mammography outcomes in longitudinal studies. METHODS: Data from the US Breast Cancer Surveillance Consortium (BCSC) and the Nijmegen Breast Cancer Screening Program in the Netherlands were

  3. When Dread Risks Are More Dreadful than Continuous Risks: Comparing Cumulative Population Losses over Time.

    Directory of Open Access Journals (Sweden)

    Nicolai Bodemer

    Full Text Available People show higher sensitivity to dread risks, rare events that kill many people at once, compared with continuous risks, relatively frequent events that kill many people over a longer period of time. The different reaction to dread risks is often considered a bias: If the continuous risk causes the same number of fatalities, it should not be perceived as less dreadful. We test the hypothesis that a dread risk may have a stronger negative impact on the cumulative population size over time in comparison with a continuous risk causing the same number of fatalities. This difference should be particularly strong when the risky event affects children and young adults who would have produced future offspring if they had survived longer. We conducted a series of simulations, with varying assumptions about population size, population growth, age group affected by risky event, and the underlying demographic model. Results show that dread risks affect the population more severely over time than continuous risks that cause the same number of fatalities, suggesting that fearing a dread risk more than a continuous risk is an ecologically rational strategy.

  4. Cumulative Risk and Teacher Well-Being in the Democratic Republic of the Congo

    Science.gov (United States)

    Wolf, Sharon; Torrente, Catalina; McCoy, Marissa; Rasheed, Damira; Aber, J. Lawrence

    2015-01-01

    Remarkably little systematic research has examined the living and working conditions for teachers in sub-Saharan Africa and how such conditions predict teacher well-being. This study assesses how various risks across several domains of teachers' lives--measured as a "cumulative risk index"--predict motivation, burnout, and job…

  5. Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

    DEFF Research Database (Denmark)

    Müller, Anne Kirstine; Nielsen, Elsa

    2008-01-01

    A cumulative risk assessment of three anti-androgenic pesticides vinclozolin, procymidone and prochloraz in combination has been carried out using an Integrated Probabilistic Risk Assessment (IPRA) model. In the model, variability in both exposure and sensitivity between individuals were combined...

  6. Cumulative Family Risk Predicts Increases in Adjustment Difficulties across Early Adolescence

    Science.gov (United States)

    Buehler, Cheryl; Gerard, Jean M.

    2013-01-01

    Family is an important socialization context for youth as they move through early adolescence. A significant feature of this complex socialization context is the accumulation of potential family risk factors that may compromise youth adjustment. This study examined cumulative family risk and adolescents' adjustment difficulties in 416 two-parent…

  7. Probabilistic cumulative risk assessment of anti-androgenic pesticides in food.

    NARCIS (Netherlands)

    Müller, A.K.; Bosgra, S.; Boon, P.E.; van der Voet, H.; Nielsen, E.; Ladefoged, O.

    2009-01-01

    In this paper, we present a cumulative risk assessment of three anti-androgenic pesticides (vinclozolin, procymidone and prochloraz) using the relative potency factor (RPF) approach and an integrated probabilistic risk assessment (IPRA) model. RPFs for each substance were estimated for three reprodu

  8. Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

    NARCIS (Netherlands)

    Muller, A.K.; Bosgra, S.; Boon, P.E.; Voet, van der H.; Nielsen, E.; Ladefoged, O.

    2009-01-01

    In this paper, we present a cumulative risk assessment of three anti-androgenic pesticides (vinclozolin, procymidone and prochloraz) using the relative potency factor (RPF) approach and an integrated probabilistic risk assessment (IPRA) model. RPFs for each substance were estimated for three reprodu

  9. Cumulative family risk predicts increases in adjustment difficulties across early adolescence.

    Science.gov (United States)

    Buehler, Cheryl; Gerard, Jean M

    2013-06-01

    Family is an important socialization context for youth as they move through early adolescence. A significant feature of this complex socialization context is the accumulation of potential family risk factors that may compromise youth adjustment. This study examined cumulative family risk and adolescents' adjustment difficulties in 416 two-parent families using four waves of annual longitudinal data (51% female youth). Risk factors in four family domains were examined: socioeconomic, parents' psychological realm, marital, and parenting. Cumulative family risk experienced while in 6th grade was associated concurrently with daughters' higher internalizing problems and with increased internalizing problems during early adolescence. Cumulative family risk was associated concurrently with sons' higher externalizing problems and with daughters' increased externalizing problems over time. Cumulative family risk was associated concurrently with lower grades and with declining grades over time for both daughters and sons. The number of risk domains also was associated with youths' adjustment difficulties during early adolescence, providing evidence that risk in two-parent families involves more than ineffective parenting. These findings suggest a critical need to provide strong support for families in reducing a variety of stressors across multiple family domains as their children traverse early adolescence.

  10. The impact of cumulative family risks on various levels of food insecurity.

    Science.gov (United States)

    Hernandez, Daphne C

    2015-03-01

    The study uses the Fragile Families and Child Well-being Study (N=2025) to examine the relationship between four cumulative family risk indices and refined measures of food hardship: marginal food security, low food security, and very low food security. Regression analyses indicate that cumulative family risk indices are useful in differentiating various levels of food insecurity. Specifically, the maternal poor health and risky health behaviors index is pertinent for distinguishing (1) food insecure from marginal food secure households and (2) very low food secure from low food secure households. In addition, the financial strain index is pertinent for differentiating between marginal food secure families from food secure families among non-poor households. Connecting food assistance programs with established social services may decrease the negative impact that cumulative family-level risk factors have on families' varying levels of food insecurity.

  11. Childhood poverty and young adults' allostatic load: the mediating role of childhood cumulative risk exposure.

    Science.gov (United States)

    Evans, Gary W; Kim, Pilyoung

    2012-09-01

    Childhood poverty is linked to a host of physical and psychological disorders during childhood and later in life. In the study reported here, we showed that the proportion of childhood spent in poverty from birth to age 9 was linked to elevated allostatic load, a marker of chronic physiological stress, in 17-year-olds. Furthermore, this prospective longitudinal relationship was mediated by cumulative risk exposure at age 13. The greater the duration of early life spent in poverty, the greater the exposure to cumulative risk. This, in turn, leads to elevated allostatic load. Multiple psychological, biological, and neurological pathways likely account for the social patterning of psychological and physical disease.

  12. Cumulative risk effects in the bullying of children and young people with autism spectrum conditions.

    Science.gov (United States)

    Hebron, Judith; Oldfield, Jeremy; Humphrey, Neil

    2017-04-01

    Students with autism are more likely to be bullied than their typically developing peers. However, several studies have shown that their likelihood of being bullied increases in the context of exposure to certain risk factors (e.g. behaviour difficulties and poor peer relationships). This study explores vulnerability to bullying from a cumulative risk perspective, where the number of risks rather than their nature is considered. A total of 722 teachers and 119 parents of young people with autism spectrum conditions participated in the study. Established risk factors were summed to form a cumulative risk score in teacher and parent models. There was evidence of a cumulative risk effect in both models, suggesting that as the number of risks increased, so did exposure to bullying. A quadratic effect was found in the teacher model, indicating that there was a disproportionate increase in the likelihood of being bullied in relation to the number of risk factors to which a young person was exposed. In light of these findings, it is proposed that more attention needs to be given to the number of risks to which children and young people with autism spectrum conditions are exposed when planning interventions and providing a suitable educational environment.

  13. Cumulative risk assessment of the intake of organophosphorus and carbamate pesticides in the Danish diet

    DEFF Research Database (Denmark)

    Jensen, A. F.; Petersen, Annette; Granby, Kit

    2003-01-01

    The aim of the study is to evaluate the potential cumulative effects of organophosphorus and carbamate pesticides that act through a common mechanism of toxicity, and to assess the long- and short-term risks for the Danish population. The intake estimates are based on dietary intake data collected...... in the Danish nation-wide food consumption survey in 1995. The pesticide data are based on the Danish pesticide residue-monitoring programme from 1996-2001. The amount of 35 organophosphorus pesticides and carbamates were included in the cumulative risk assessment. Processing factors, such as reduction...... of pesticide levels by rinsing and peeling, were applied in the exposure assessment. The "Toxicity Equivalence Factor" (TEF) approach was used to normalise the toxicity of the different organophosphorus and carbamate pesticides. Cumulative chronic exposure of organophosphorus and carbamates pesticides via...

  14. New approaches to uncertainty analysis for use in aggregate and cumulative risk assessment of pesticides

    NARCIS (Netherlands)

    Kennedy, M.C.; Voet, van der H.; Roelofs, V.J.; Roelofs, W.; Glass, C.R.; Boer, de W.J.; Kruisselbrink, J.W.; Hart, A.D.M.

    2015-01-01

    Risk assessments for human exposures to plant protection products (PPPs) have traditionally focussed on single routes of exposure and single compounds. Extensions to estimate aggregate (multi-source) and cumulative (multi-compound) exposure from PPPs present many new challenges and additional uncert

  15. Associations between parenting, media use, cumulative risk, and children’s executive functioning

    NARCIS (Netherlands)

    Linebarger, D.L.; Barr, R.; Lapierre, M.A.; Piotrowski, J.

    2014-01-01

    Objective: This study was designed to examine how parenting style, media exposure, and cumulative risk were associated with executive functioning (EF) during early childhood. Methods: A nationally representative group of US parents/caregivers (N = 1156) with 1 child between 2 and 8 years

  16. Effects of Cumulative Family Risk Factors on American Students' Academic Performance

    Science.gov (United States)

    Dunst, Carl J.; Hamby, Deborah W.

    2016-01-01

    The relationships between cumulative family risk factors and American students' academic performance were examined in all 50 States and the District of Columbia. Data from the 2007 "American Community Survey" were used to ascertain the percent of birth to 18 year old children in the United States who experienced three or more risk…

  17. 76 FR 82296 - Pyrethrins/Pyrethroid Cumulative Risk Assessment; Extension of Comment Period

    Science.gov (United States)

    2011-12-30

    ... AGENCY Pyrethrins/Pyrethroid Cumulative Risk Assessment; Extension of Comment Period AGENCY: Environmental Protection Agency (EPA). ACTION: Notice; extension of comment period. SUMMARY: EPA issued a notice... called ``the pyrethroids'') and opened a public comment period on this document and other supporting...

  18. Parenting intervention and the caregiving environment : cumulative risk and process evaluation

    NARCIS (Netherlands)

    Stolk, Mirjam Neeltje

    2007-01-01

    The objective of the research described in this thesis was to study single and cumulative family risk in relation to early childhood externalizing problems and the effectiveness of a parenting intervention program. The Video-feedback Intervention to promote Positive Parenting and Sensitive Disciplin

  19. Associations between parenting, media use, cumulative risk, and children’s executive functioning

    NARCIS (Netherlands)

    D.L. Linebarger; R. Barr; M.A. Lapierre; J. Piotrowski

    2014-01-01

    Objective: This study was designed to examine how parenting style, media exposure, and cumulative risk were associated with executive functioning (EF) during early childhood. Methods: A nationally representative group of US parents/caregivers (N = 1156) with 1 child between 2 and 8 years participate

  20. Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach

    DEFF Research Database (Denmark)

    Søeborg, T; Frederiksen, H; Andersson, Anna-Maria

    2012-01-01

    and adolescents and resulting estimated daily intakes of four different phthalates. These daily intake estimates are used for a cumulative risk assessment with anti-androgenic effects as the endpoint using Tolerable Daily Intake (TDI) values determined by the European Food Safety Authorities (EFSA) or Reference...... endpoint for the phthalates included in this article. Using the EFSA TDI values, 12 children exceeded the hazard quotient for the sum of di-n-butyl phthalate and di-iso-butyl phthalate (∑DBP((i+n)) ) and one child exceeded the hazard quotient for di-(2-ethylhexyl)phthalate (DEHP). Nineteen children...... exceeded the cumulated hazard index for three phthalates. Using the RfD AA values, one child exceeded the hazard quotient for DEHP and the same child exceeded the cumulated hazard index for four phthalates. The EFSA TDI approach thus is more restrictive and identifies ∑DBP((i+n)) as the compound...

  1. Cumulative Risk Assessment: An Overview of Methodological Approaches for Evaluating Combined Health Effects from Exposure to Multiple Environmental Stressors

    Science.gov (United States)

    Sexton, Ken

    2012-01-01

    Systematic evaluation of cumulative health risks from the combined effects of multiple environmental stressors is becoming a vital component of risk-based decisions aimed at protecting human populations and communities. This article briefly examines the historical development of cumulative risk assessment as an analytical tool, and discusses current approaches for evaluating cumulative health effects from exposure to both chemical mixtures and combinations of chemical and nonchemical stressors. A comparison of stressor-based and effects-based assessment methods is presented, and the potential value of focusing on viable risk management options to limit the scope of cumulative evaluations is discussed. The ultimate goal of cumulative risk assessment is to provide answers to decision-relevant questions based on organized scientific analysis; even if the answers, at least for the time being, are inexact and uncertain. PMID:22470298

  2. Modelling the cumulative risk of a false-positive screening test.

    Science.gov (United States)

    Hubbard, Rebecca A; Miglioretti, Diana L; Smith, Robert A

    2010-10-01

    The goal of a screening test is to reduce morbidity and mortality through the early detection of disease; but the benefits of screening must be weighed against potential harms, such as false-positive (FP) results, which may lead to increased healthcare costs, patient anxiety, and other adverse outcomes associated with diagnostic follow-up procedures. Accurate estimation of the cumulative risk of an FP test after multiple screening rounds is important for program evaluation and goal setting, as well as informing individuals undergoing screening what they should expect from testing over time. Estimation of the cumulative FP risk is complicated by the existence of censoring and possible dependence of the censoring time on the event history. Current statistical methods for estimating the cumulative FP risk from censored data follow two distinct approaches, either conditioning on the number of screening tests observed or marginalizing over this random variable. We review these current methods, identify their limitations and possibly unrealistic assumptions, and propose simple extensions to address some of these limitations. We discuss areas where additional extensions may be useful. We illustrate methods for estimating the cumulative FP recall risk of screening mammography and investigate the appropriateness of modelling assumptions using 13 years of data collected by the Breast Cancer Surveillance Consortium (BCSC). In the BCSC data we found evidence of violations of modelling assumptions of both classes of statistical methods. The estimated risk of an FP recall after 10 screening mammograms varied between 58% and 77% depending on the approach used, with an estimate of 63% based on what we feel are the most reasonable modelling assumptions.

  3. Cumulative Doses of T-Cell Depleting Antibody and Cancer Risk after Kidney Transplantation.

    Directory of Open Access Journals (Sweden)

    Jenny H C Chen

    Full Text Available T-cell depleting antibody is associated with an increased risk of cancer after kidney transplantation, but a dose-dependent relationship has not been established. This study aimed to determine the association between cumulative doses of T-cell depleting antibody and the risk of cancer after kidney transplantation. Using data from the Australian and New Zealand Dialysis and Transplant Registry between 1997-2012, we assessed the risk of incident cancer and cumulative doses of T-cell depleting antibody using adjusted Cox regression models. Of the 503 kidney transplant recipients with 2835 person-years of follow-up, 276 (55%, 209 (41% and 18 (4% patients received T-cell depleting antibody for induction, rejection or induction and rejection respectively. The overall cancer incidence rate was 1,118 cancers per 100,000 patient-years, with 975, 1093 and 1377 cancers per 100,000 patient-years among those who had received 1-5 doses, 6-10 doses and >10 doses, respectively. There was no association between cumulative doses of T cell depleting antibody and risk of incident cancer (1-5: referent, 6-10: adjusted hazard ratio (HR 1.19, 95%CI 0.48-2.95, >10: HR 1.42, 95%CI 0.50-4.02, p = 0.801. This lack of association is contradictory to our hypothesis and is likely attributed to the low event rates resulting in insufficient power to detect significant differences.

  4. Modeling Joint Exposures and Health Outcomes for Cumulative Risk Assessment: The Case of Radon and Smoking

    Directory of Open Access Journals (Sweden)

    Jonathan I. Levy

    2011-09-01

    Full Text Available Community-based cumulative risk assessment requires characterization of exposures to multiple chemical and non-chemical stressors, with consideration of how the non-chemical stressors may influence risks from chemical stressors. Residential radon provides an interesting case example, given its large attributable risk, effect modification due to smoking, and significant variability in radon concentrations and smoking patterns. In spite of this fact, no study to date has estimated geographic and sociodemographic patterns of both radon and smoking in a manner that would allow for inclusion of radon in community-based cumulative risk assessment. In this study, we apply multi-level regression models to explain variability in radon based on housing characteristics and geological variables, and construct a regression model predicting housing characteristics using U.S. Census data. Multi-level regression models of smoking based on predictors common to the housing model allow us to link the exposures. We estimate county-average lifetime lung cancer risks from radon ranging from 0.15 to 1.8 in 100, with high-risk clusters in areas and for subpopulations with high predicted radon and smoking rates. Our findings demonstrate the viability of screening-level assessment to characterize patterns of lung cancer risk from radon, with an approach that can be generalized to multiple chemical and non-chemical stressors.

  5. Covariate adjustment of cumulative incidence functions for competing risks data using inverse probability of treatment weighting.

    Science.gov (United States)

    Neumann, Anke; Billionnet, Cécile

    2016-06-01

    In observational studies without random assignment of the treatment, the unadjusted comparison between treatment groups may be misleading due to confounding. One method to adjust for measured confounders is inverse probability of treatment weighting. This method can also be used in the analysis of time to event data with competing risks. Competing risks arise if for some individuals the event of interest is precluded by a different type of event occurring before, or if only the earliest of several times to event, corresponding to different event types, is observed or is of interest. In the presence of competing risks, time to event data are often characterized by cumulative incidence functions, one for each event type of interest. We describe the use of inverse probability of treatment weighting to create adjusted cumulative incidence functions. This method is equivalent to direct standardization when the weight model is saturated. No assumptions about the form of the cumulative incidence functions are required. The method allows studying associations between treatment and the different types of event under study, while focusing on the earliest event only. We present a SAS macro implementing this method and we provide a worked example.

  6. The impact of physical activity on cumulative cardiovascular disease risk factors among Malaysian adults.

    Science.gov (United States)

    Rasiah, Rajah; Thangiah, Govindamal; Yusoff, Khalid; Manikam, Rishya; Chandrasekaran, Sankara Kumar; Mustafa, Rujhan; Bakar, Najmin Binti Abu

    2015-12-16

    Numerous studies have shown the importance of physical activity in reducing the morbidity and mortality rates caused by cardiovascular disease (CVD). However, most of these studies emphasise little on the cumulative effect of CVD risk factors. Hence, this study investigates the association between physical exercise and cumulative CVD risk factors among adults in three different age groups. Using a sample of 7276 respondents drawn from community centers, the REDISCOVER team gathered information on physical activity, CVD risk factors (obesity, diabetes, hypertension, hypercholesterolemia, tobacco use) and socioeconomic and demographic variables in Malaysia. Because the study required medical examination, a convenience sampling frame was preferred in which all volunteers were included in the study. Fasting blood samples and anthropometric (height, weight and more) measurements were collected by trained staffs. Socio-demographic and physical activity variables were recorded through questionnaires. A Chi-square test was performed to identify the bivariate association between the covariates (socioeconomic variables, demographic variables and physical activity) and outcome variable. The association between the main exposure, physical activity, and the outcome variable, cumulative CVD risk factors, was assessed using an ordinal logistic regression model, controlling for socioeconomic status and demographic influences in three different age groups, 35-49, 50-64 and 65 and above. The mean age of participants is 51.8 (SD = 9.4). Respondents in the age groups of 35-49 (aORmoderate = 0.12; 95 % CI: 0.02 - 0.53 ) and 65 and above (aORhigh = 0.58; 95 % CI: 0.24, 0.78) showed a statistically significant inverse relationship between physical activity and cumulative CVD risk factors. However, this relationship was not significant among respondents in the 50-64 age group suggesting the possible influence of other variables, such as stress and environment. The

  7. Cumulative association of obstructive sleep apnea severity and short sleep duration with the risk for hypertension.

    Directory of Open Access Journals (Sweden)

    Pascaline Priou

    Full Text Available Obstructive sleep apnea (OSA and short sleep duration are individually associated with an increased risk for hypertension (HTN. The aim of this multicenter cross-sectional study was to test the hypothesis of a cumulative association of OSA severity and short sleep duration with the risk for prevalent HTN. Among 1,499 patients undergoing polysomnography for suspected OSA, 410 (27.3% previously diagnosed as hypertensive and taking antihypertensive medication were considered as having HTN. Patients with total sleep time (TST <6 h were considered to be short sleepers. Logistic regression procedures were performed to determine the independent association of HTN with OSA and sleep duration. Considering normal sleepers (TST ≥6 h without OSA as the reference group, the odds ratio (OR (95% confidence intervals for having HTN was 2.51 (1.35-4.68 in normal sleepers with OSA and 4.37 (2.18-8.78 in short sleepers with OSA after adjustment for age, gender, obesity, diabetes, depression, current smoking, use of thyroid hormones, daytime sleepiness, poor sleep complaint, time in bed, sleep architecture and fragmentation, and study site. The risk for HTN appeared to present a cumulative association with OSA severity and short sleep duration (p<0.0001 for linear trend. The higher risk for HTN was observed in short sleepers with severe OSA (AHI ≥30 (OR, 4.29 [2.03-9.07]. In patients investigated for suspected OSA, sleep-disordered breathing severity and short sleep duration have a cumulative association with the risk for prevalent HTN. Further studies are required to determine whether interventions to optimize sleep may contribute to lower BP in patients with OSA.

  8. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.

    Science.gov (United States)

    Wang, Joanne H; Pappas, Derek; De Jager, Philip L; Pelletier, Daniel; de Bakker, Paul Iw; Kappos, Ludwig; Polman, Chris H; Chibnik, Lori B; Hafler, David A; Matthews, Paul M; Hauser, Stephen L; Baranzini, Sergio E; Oksenberg, Jorge R

    2011-01-18

    Multiple sclerosis (MS) is the most common cause of chronic neurologic disability beginning in early to middle adult life. Results from recent genome-wide association studies (GWAS) have substantially lengthened the list of disease loci and provide convincing evidence supporting a multifactorial and polygenic model of inheritance. Nevertheless, the knowledge of MS genetics remains incomplete, with many risk alleles still to be revealed. We used a discovery GWAS dataset (8,844 samples, 2,124 cases and 6,720 controls) and a multi-step logistic regression protocol to identify novel genetic associations. The emerging genetic profile included 350 independent markers and was used to calculate and estimate the cumulative genetic risk in an independent validation dataset (3,606 samples). Analysis of covariance (ANCOVA) was implemented to compare clinical characteristics of individuals with various degrees of genetic risk. Gene ontology and pathway enrichment analysis was done using the DAVID functional annotation tool, the GO Tree Machine, and the Pathway-Express profiling tool. In the discovery dataset, the median cumulative genetic risk (P-Hat) was 0.903 and 0.007 in the case and control groups, respectively, together with 79.9% classification sensitivity and 95.8% specificity. The identified profile shows a significant enrichment of genes involved in the immune response, cell adhesion, cell communication/signaling, nervous system development, and neuronal signaling, including ionotropic glutamate receptors, which have been implicated in the pathological mechanism driving neurodegeneration. In the validation dataset, the median cumulative genetic risk was 0.59 and 0.32 in the case and control groups, respectively, with classification sensitivity 62.3% and specificity 75.9%. No differences in disease progression or T2-lesion volumes were observed among four levels of predicted genetic risk groups (high, medium, low, misclassified). On the other hand, a significant

  9. OPS Master

    Data.gov (United States)

    US Agency for International Development — OPS Master is a management tool and database for integrated financial planning and portfolio management in USAID Missions. Using OPS Master, the three principal...

  10. Cumulative family risks across income levels predict deterioration of children's general health during childhood and adolescence.

    Science.gov (United States)

    Lin, Yi-Ching; Seo, Dong-Chul

    2017-01-01

    Family is considered an important agent in the health development of children. This process is significant but quite complex because the prevalence of potential risk factors in the family can hinder children's health. This study examined if multiple family risks might have cumulative effect on children and youth's health across various levels of household income. The data in this study were drawn from the 2011-2012 U.S. National Survey of Children's Health (N = 79,601). A cumulative family risk (CFR) index was developed, which included such constructs as single-parenthood, unstable employment, large family, parenting stress, poor maternal education, poor maternal general health and poor maternal mental health. Multiple logistic regression analyses showed that CFR level was significantly related to children and youth's poor health outcome (p families than on those from poor families. Overall there was a consistent pattern of trend in the point estimate as well as confidence limits as levels of affluence and numbers of family risk increased although some of the confidence intervals overlapped. Living in disadvantaged families might serve as a protective factor against CFRs possibly through repeated exposure to hardships and subsequent formation of resilience among some of the disadvantaged children.

  11. DOSE-RESPONSE MODELING FOR THE ASSESSMENT OF CUMULATIVE RISK DUE TO EXPOSURE TO N-METHYL CARBAMATE PESTICIDES

    Science.gov (United States)

    The US EPAs N-Methyl Carbamate Cumulative Risk Assessment (NMCRA) assesses the effect on acetylcholine esterase (AChE) activity of exposure to 10 N-methyl carbamate (NMC) pesticides through dietary, drinking water, and residential exposures.

  12. Nonparametric Estimation of Cumulative Incidence Functions for Competing Risks Data with Missing Cause of Failure

    DEFF Research Database (Denmark)

    Effraimidis, Georgios; Dahl, Christian Møller

    In this paper, we develop a fully nonparametric approach for the estimation of the cumulative incidence function with Missing At Random right-censored competing risks data. We obtain results on the pointwise asymptotic normality as well as the uniform convergence rate of the proposed nonparametric...... estimator. A simulation study that serves two purposes is provided. First, it illustrates in details how to implement our proposed nonparametric estimator. Secondly, it facilitates a comparison of the nonparametric estimator to a parametric counterpart based on the estimator of Lu and Liang (2008...

  13. Cumulative risk and developmental health: an argument for the importance of a family-wide science.

    Science.gov (United States)

    Browne, Dillon T; Plamondon, Andre; Prime, Heather; Puente-Duran, Sofia; Wade, Mark

    2015-01-01

    A substantial body of research links social disadvantage and developmental health via a cascade running from poverty, to cumulative psychosocial risk, to disrupted family dynamics, to child biological regulatory systems and neurocognitive processing, and finally to morbidity across the lifespan. Most research in this area employs single-dyad or between-family methodology. While informative, there are limitations to this approach. Specifically, it is impossible to determine how risk alters psychosocial environments that are similar for all persons within a household, versus processes that are unique to particular children. This is important in light of literature citing the primacy of child-specific environments in driving developmental health. Methodologically speaking, there are both benefits and challenges to family-wide approaches that differentiate between- and within-family environments. This review describes literature linking cumulative risk and developmental health via family process, while articulating the importance of family-wide approaches. Areas of shortcoming and recommendations for a family-wide science are provided.

  14. A semiparametric censoring bias model for estimating the cumulative risk of a false-positive screening test under dependent censoring.

    Science.gov (United States)

    Hubbard, Rebecca A; Miglioretti, Diana L

    2013-03-01

    False-positive test results are among the most common harms of screening tests and may lead to more invasive and expensive diagnostic testing procedures. Estimating the cumulative risk of a false-positive screening test result after repeat screening rounds is, therefore, important for evaluating potential screening regimens. Existing estimators of the cumulative false-positive risk are limited by strong assumptions about censoring mechanisms and parametric assumptions about variation in risk across screening rounds. To address these limitations, we propose a semiparametric censoring bias model for cumulative false-positive risk that allows for dependent censoring without specifying a fixed functional form for variation in risk across screening rounds. Simulation studies demonstrated that the censoring bias model performs similarly to existing models under independent censoring and can largely eliminate bias under dependent censoring. We used the existing and newly proposed models to estimate the cumulative false-positive risk and variation in risk as a function of baseline age and family history of breast cancer after 10 years of annual screening mammography using data from the Breast Cancer Surveillance Consortium. Ignoring potential dependent censoring in this context leads to underestimation of the cumulative risk of false-positive results. Models that provide accurate estimates under dependent censoring are critical for providing appropriate information for evaluating screening tests.

  15. Predicting Academic Achievement from Cumulative Home Risk: The Mediating Roles of Effortful Control, Academic Relationships, and School Avoidance

    Science.gov (United States)

    Swanson, Jodi; Valiente, Carlos; Lemery-Chalfant, Kathryn

    2012-01-01

    Components of the home environment are associated with children's academic functioning. The accumulation of risks in the home are expected to prove more detrimental to achievement than any one risk alone, but the processes accounting for this relation are unclear. Using an index of cumulative home risk (CHR) inclusive of protective factors, as…

  16. Prevalence and risk factors of upper extremity cumulative trauma disorder in dental hygienists.

    Science.gov (United States)

    Shenkar, O; Mann, J; Shevach, A; Ever-Hadani, P; Weiss, P L

    1998-01-01

    Cumulative trauma disorder (CTD) refers to a number of conditions arising from overuse of joints or soft tissues. The common risk factors that contribute to the development of these disorders are related to personal and occupational variables. Job analysis of the tasks performed by the dental hygienist have shown that this occupation is particularly at risk. The objectives of this study were to determine the prevalence of CTD symptoms amongst dental hygienists in Israel and to identify which are the factors that are related to CTD. A questionnaire including items concerning demographic data, employment history, professional occupational information, use of instrumentation, and CTD symptomatology was mailed to all 530 registered dental hygienists. Two hundred forty-six hygienists (46%) returned the questionnaire; 63% of the respondents were classified as CTD 'sufferers', Age, year of graduation, hours worked per week, and frequency of changing instruments were found to be significantly related to CTD symptoms. Hygienists at high risk included those aged 50 years or more (Odds ratio, OR = 6), those who graduated before 1986 (OR = 3), those who work more than 34 h per week (OR = 2.5) and those who change two or fewer instruments per patient (OR = 2). The major recommendation resulting from this study is to make dental hygienists aware that they work in a high-risk profession. It is hoped that increased awareness of the risk will spur the hygienist to make appropriate work practice, administrative, and engineering modifications and to seek treatment at the first indication of CTD symptoms.

  17. Potential Health Risks Posed by Plant-Derived Cumulative Neurotoxic Bufadienolides in South Africa

    Directory of Open Access Journals (Sweden)

    Christo Botha

    2016-03-01

    Full Text Available Bufadienolide-type cardiac glycosides have a worldwide distribution and are mainly synthesized by plants, but there are also animal sources. In South Africa, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe cause a unique chronic form of cardiac glycoside poisoning, predominantly in small stock. This paretic/paralytic condition is referred to as “krimpsiekte”, cotyledonosis or “nenta”. “Krimpsiekte” is a plant poisoning only reported from South Africa and is regarded as the most important plant poisoning of small stock in the semi-arid Little Karoo and southern fringes of the Great Karoo. The toxicosis is caused by cumulative bufadienolides which have neurotoxic properties. Four types of cumulative neurotoxic bufadienolides, namely cotyledoside, and the tyledosides, orbicusides and lanceotoxins, have been isolated. Based on the structure activity relationships and certain toxicokinetic parameters possible reasons for their accumulation are presented. Consumption of edible tissues from animals that have ingested these plants poses a potential risk to humans.

  18. Optimization of the cumulative risk assessment of pesticides and biocides using computational techniques: Pilot project

    DEFF Research Database (Denmark)

    Jonsdottir, Svava Osk; Reffstrup, Trine Klein; Petersen, Annette

    This pilot project is intended as the first step in developing a computational strategy to assist in refining methods for higher tier cumulative and aggregate risk assessment of exposure to mixture of pesticides and biocides. For this purpose, physiologically based toxicokinetic (PBTK) models were...... developed for two compounds, tebuconazole and prochloraz, and a binary mixture of these compounds in two species, rat and human. PBTK models can be used to estimate the concentration levels (internal doses) of toxic substances and their metabolites in blood and tissue, by a collection of differential...... the models. Exposure scenarios were constructed based on findings of pesticide residues in food of ordinary consumers, and assessment of dermal exposure of professional workers. PBTK simulations were carried using these scenarios....

  19. When Two Isn't Better than One: Predictors of Early Sexual Activity in Adolescence Using a Cumulative Risk Model

    Science.gov (United States)

    Price, Myeshia N.; Hyde, Janet Shibley

    2009-01-01

    This study explored factors that may be associated with early initiation of sexual activity among adolescents. Using the cumulative risk model, we hypothesized that as exposure to risk factors increases, so does the likelihood of early sexual debut. A sample of 273 (53% girls, 90% European American) adolescents was followed longitudinally from age…

  20. Serious, Minor, and Non-Delinquents in Early Adolescence : The Impact of Cumulative Risk and Promotive Factors. The TRAILS Study

    NARCIS (Netherlands)

    van der Laan, A.M.; Veenstra, R.; Bogaerts, S.; Verhulst, F.C.; Ormel, J.

    2010-01-01

    This study uses a social-ecological approach to the development of delinquency. The authors emphasize that a balance between eliminating risk and enhancing protection across domains is essential in reducing problems and promoting competence. The cumulative risk and promotive effects of temperament,

  1. Cumulative Cardiovascular Polypharmacy Is Associated With the Risk of Acute Kidney Injury in Elderly Patients.

    Science.gov (United States)

    Chao, Chia-Ter; Tsai, Hung-Bin; Wu, Chia-Yi; Lin, Yu-Feng; Hsu, Nin-Chieh; Chen, Jin-Shin; Hung, Kuan-Yu

    2015-08-01

    Polypharmacy is common in the elderly due to multimorbidity and interventions. However, the temporal association between polypharmacy and renal outcomes is rarely addressed and recognized. We investigated the association between cardiovascular (CV) polypharmacy and the risk of acute kidney injury (AKI) in elderly patients.We used the Taiwan National Health Insurance PharmaCloud system to investigate the relationship between cumulative CV medications in the 3 months before admission and risk of AKI in the elderly at their admission to general medical wards in a single center. Community-dwelling elderly patients (>60 years) were prospectively enrolled and classified according to the number of preadmission CV medications. CV polypharmacy was defined as use of 2 or more CV medications.We enrolled 152 patients, 48% with AKI (based upon Kidney Disease Improving Global Outcomes [KDIGO] classification) and 64% with CV polypharmacy. The incidence of AKI was higher in patients taking more CV medications (0 drugs: 33%; 1 drug: 50%; 2 drugs: 57%; 3 or more drugs: 60%; P = 0.05) before admission. Patients with higher KDIGO grades also took more preadmission CV medications (P = 0.04). Multiple regression analysis showed that patients who used 1 or more CV medications before admission had increased risk of AKI at admission (1 drug: odds ratio [OR] = 1.63, P = 0.2; 2 drugs: OR = 4.74, P = 0.03; 3 or more drugs: OR = 5.92, P = 0.02), and that CV polypharmacy is associated with higher risk of AKI (OR 2.58; P = 0.02). Each additional CV medication increased the risk for AKI by 30%.We found that elderly patients taking more CV medications are associated with risk of adverse renal events. Further study to evaluate whether interventions that reduce polypharmacy could reduce the incidence of geriatric AKI is urgently needed.

  2. Comparison of competing risks models based on cumulative incidence function in analyzing time to cardiovascular diseases.

    Science.gov (United States)

    Dianatkhah, Minoo; Rahgozar, Mehdi; Talaei, Mohammad; Karimloua, Masoud; Sadeghi, Masoumeh; Oveisgharan, Shahram; Sarrafzadegan, Nizal

    2014-01-01

    Competing risks arise when the subject is exposed to more than one cause of failure. Data consists of the time that the subject failed and an indicator of which risk caused the subject to fail. With three approaches consisting of Fine and Gray, binomial, and pseudo-value, all of which are directly based on cumulative incidence function, cardiovascular disease data of the Isfahan Cohort Study were analyzed. Validity of proportionality assumption for these approaches is the basis for selecting appropriate models. Such as for the Fine and Gray model, establishing proportionality assumption is necessary. In the binomial approach, a parametric, non-parametric, or semi-parametric model was offered according to validity of assumption. However, pseudo-value approaches do not need to establish proportionality. Following fitting the models to data, slight differences in parameters and variances estimates were seen among models. This showed that semi-parametric multiplicative model and the two models based on pseudo-value approach could be used for fitting this kind of data. We would recommend considering the use of competing risk models instead of normal survival methods when subjects are exposed to more than one cause of failure.

  3. Cumulative risk effects for the development of behaviour difficulties in children and adolescents with special educational needs and disabilities.

    Science.gov (United States)

    Oldfield, Jeremy; Humphrey, Neil; Hebron, Judith

    2015-01-01

    Research has identified multiple risk factors for the development of behaviour difficulties. What have been less explored are the cumulative effects of exposure to multiple risks on behavioural outcomes, with no study specifically investigating these effects within a population of young people with special educational needs and disabilities (SEND). Furthermore, it is unclear whether a threshold or linear risk model better fits the data for this population. The sample included 2660 children and 1628 adolescents with SEND. Risk factors associated with increases in behaviour difficulties over an 18-month period were summed to create a cumulative risk score, with this explanatory variable being added into a multi-level model. A quadratic term was then added to test the threshold model. There was evidence of a cumulative risk effect, suggesting that exposure to higher numbers of risk factors, regardless of their exact nature, resulted in increased behaviour difficulties. The relationship between risk and behaviour difficulties was non-linear, with exposure to increasing risk having a disproportionate and detrimental impact on behaviour difficulties in child and adolescent models. Interventions aimed at reducing behaviour difficulties need to consider the impact of multiple risk variables. Tailoring interventions towards those exposed to large numbers of risks would be advantageous.

  4. The role of violent media preference in cumulative developmental risk for violence and general aggression.

    Science.gov (United States)

    Boxer, Paul; Huesmann, L Rowell; Bushman, Brad J; O'Brien, Maureen; Moceri, Dominic

    2009-03-01

    The impact of exposure to violence in the media on the long-term development and short-term expression of aggressive behavior has been well documented. However, gaps in this literature remain, and in particular the role of violent media exposure in shaping violent and other serious antisocial behavior has not been investigated. Further, studies of violent media effects typically have not sampled from populations with confirmed histories of violent and/or nonviolent antisocial behavior. In this study, we analyzed data on 820 youth, including 390 juvenile delinquents and 430 high school students, to examine the relation of violent media use to involvement in violence and general aggression. Using criterion scores developed through cross-informant modeling of data from self, parent/guardian, and teacher/staff reports, we observed that childhood and adolescent violent media preferences contributed significantly to the prediction of violence and general aggression from cumulative risk totals. Findings represent a new and important direction for research on the role of violent media use in the broader matrix of risk factors for youth violence.

  5. Cumulative risk assessment for plasticizer-contaminated food using the hazard index approach.

    Science.gov (United States)

    Chang, J W; Chen, C Y; Yan, B R; Chang, M H; Tseng, S H; Kao, Y M; Chen, J C; Lee, C C

    2014-06-01

    Phthalates strongly and adversely affect reproduction, development and liver function. We did a cumulative risk assessment for simultaneous exposure to nine phthalates using the hazard index (HI) and the levels of nine phthalates in 1200 foodstuff samples. DEHP (di-2-ethylhexyl phthalate) present the highest level (mean: 0.443 mg/kg) in 1200 samples, and the highest average daily dose (ADD) was found in DEHP, ΣDBP(i + n) (the sum of dibutyl phthalate [DBP] isomers [DnBP + DiBP]) posed the highest risk potential of all the phthalates. In seven phthalates, the 95th percentiles of the ADDs for ΣDBP(i + n) in 0-6-yr-old children accounted for 91% (79-107%) of the tolerable daily intake, and the 95th percentiles of the HIs for the anti-androgenic effects of five phthalates in 0-3-yr-old children and 4-6-yr-old girls were >1. We conclude that the health of younger Taiwanese may be adversely affected by overexposure of phthalate-contaminated foods.

  6. Non-chemical stressors and cumulative risk assessment: an overview of current initiatives and potential air pollutant interactions.

    Science.gov (United States)

    Lewis, Ari S; Sax, Sonja N; Wason, Susan C; Campleman, Sharan L

    2011-06-01

    Regulatory agencies are under increased pressure to consider broader public health concerns that extend to multiple pollutant exposures, multiple exposure pathways, and vulnerable populations. Specifically, cumulative risk assessment initiatives have stressed the importance of considering both chemical and non-chemical stressors, such as socioeconomic status (SES) and related psychosocial stress, in evaluating health risks. The integration of non-chemical stressors into a cumulative risk assessment framework has been largely driven by evidence of health disparities across different segments of society that may also bear a disproportionate risk from chemical exposures. This review will discuss current efforts to advance the field of cumulative risk assessment, highlighting some of the major challenges, discussed within the construct of the traditional risk assessment paradigm. Additionally, we present a summary of studies of potential interactions between social stressors and air pollutants on health as an example of current research that supports the incorporation of non-chemical stressors into risk assessment. The results from these studies, while suggestive of possible interactions, are mixed and hindered by inconsistent application of social stress indicators. Overall, while there have been significant advances, further developments across all of the risk assessment stages (i.e., hazard identification, exposure assessment, dose-response, and risk characterization) are necessary to provide a scientific basis for regulatory actions and effective community interventions, particularly when considering non-chemical stressors. A better understanding of the biological underpinnings of social stress on disease and implications for chemical-based dose-response relationships is needed. Furthermore, when considering non-chemical stressors, an appropriate metric, or series of metrics, for risk characterization is also needed. Cumulative risk assessment research will benefit

  7. Oral contraceptive use and impact of cumulative intake of estrogen and progestin on risk of ovarian cancer

    DEFF Research Database (Denmark)

    Faber, M T; Jensen, A; Frederiksen, K

    2013-01-01

    women aged 35–79 years; 554 women with epithelial ovarian cancer and 1,564 age-matched controls were included in the analyses. Data were analyzed in multiple logistic regression models. RESULTS: The use of combined oral contraceptives only and the mixed use of combined and progestin-only pills decreased...... the risk of ovarian cancer, while no association was found with exclusive use of progestin-only pills. No major differences in risk were found for users of combined oral contraceptives with high- and low-potency estrogen and progestin. There was no effect of cumulative progestin intake, but decreased risks......PURPOSE: Oral contraceptive use decreases the risk of ovarian cancer, but no previous studies have assessed the impact of cumulative intake of estrogen and progestin on ovarian cancer risk. METHODS: We used data from a population-based case–control study conducted in Denmark in 1995–1999 among...

  8. Cumulative health risk assessment of 17 perfluoroalkylated and polyfluoroalkylated substances (PFASs) in the Swedish population.

    Science.gov (United States)

    Borg, Daniel; Lund, Bert-Ove; Lindquist, Nils-Gunnar; Håkansson, Helen

    2013-09-01

    Humans are simultaneously exposed to a multitude of chemicals. Human health risk assessment of chemicals is, however, normally performed on single substances, which may underestimate the total risk, thus bringing a need for reliable methods to assess the risk of combined exposure to multiple chemicals. Per- and polyfluoroalkylated substances (PFASs) is a large group of chemicals that has emerged as global environmental contaminants. In the Swedish population, 17 PFASs have been measured, of which the vast majority lacks human health risk assessment information. The objective of this study was to for the first time perform a cumulative health risk assessment of the 17 PFASs measured in the Swedish population, individually and in combination, using the Hazard Index (HI) approach. Swedish biomonitoring data (blood/serum concentrations of PFASs) were used and two study populations identified: 1) the general population exposed indirectly via the environment and 2) occupationally exposed professional ski waxers. Hazard data used were publicly available toxicity data for hepatotoxicity and reproductive toxicity as well as other more sensitive toxic effects. The results showed that PFASs concentrations were in the low ng/ml serum range in the general population, reaching high ng/ml and low μg/ml serum concentrations in the occupationally exposed. For those congeners lacking toxicity data with regard to hepatotoxicity and reproductive toxicity read-across extrapolations was performed. Other effects at lower dose levels were observed for some well-studied congeners. The risk characterization showed no concern for hepatotoxicity or reproductive toxicity in the general population except in a subpopulation eating PFOS-contaminated fish, illustrating that high local exposure may be of concern. For the occupationally exposed there was concern for hepatotoxicity by PFOA and all congeners in combination as well as for reproductive toxicity by all congeners in combination, thus a

  9. A cumulative risk factor model for early identification of academic difficulties in premature and low birth weight infants

    NARCIS (Netherlands)

    Roberts, G.; Bellinger, D.; McCormick, Marie C.

    2007-01-01

    Objectives: Premature and low birth weight children have a high prevalence of academic difficulties. This study examines a model comprised of cumulative risk factors that allows early identification of these difficulties. Methods: This is a secondary analysis of data from a large cohort of premature

  10. Cumulative Risk and Adolescent's Internalizing and Externalizing Problems: The Mediating Roles of Maternal Responsiveness and Self-Regulation

    Science.gov (United States)

    Doan, Stacey N.; Fuller-Rowell, Thomas E.; Evans, Gary W.

    2012-01-01

    The purpose of the present study was to examine longitudinal associations among maternal responsiveness, self-regulation, and behavioral adjustment in adolescents. The authors used structural equation modeling to test a model that demonstrates that the effects of early cumulative risk on behavioral problems is mediated by maternal responsiveness…

  11. Benchmark Dose Analysis from Multiple Datasets: The Cumulative Risk Assessment for the N-Methyl Carbamate Pesticides

    Science.gov (United States)

    The US EPA’s N-Methyl Carbamate (NMC) Cumulative Risk assessment was based on the effect on acetylcholine esterase (AChE) activity of exposure to 10 NMC pesticides through dietary, drinking water, and residential exposures, assuming the effects of joint exposure to NMCs is dose-...

  12. Cumulative Socioeconomic Status Risk, Allostatic Load, and Adjustment: A Prospective Latent Profile Analysis with Contextual and Genetic Protective Factors

    Science.gov (United States)

    Brody, Gene H.; Yu, Tianyi; Chen, Yi-Fu; Kogan, Steven M.; Evans, Gary W.; Beach, Steven R. H.; Windle, Michael; Simons, Ronald L.; Gerrard, Meg; Gibbons, Frederick X.; Philibert, Robert A.

    2013-01-01

    The health disparities literature has identified a common pattern among middle-aged African Americans that includes high rates of chronic disease along with low rates of psychiatric disorders despite exposure to high levels of cumulative socioeconomic status (SES) risk. The current study was designed to test hypotheses about the developmental…

  13. Cumulative biomedical risk and social cognition in the second year of life: prediction and moderation by responsive parenting.

    Science.gov (United States)

    Wade, Mark; Madigan, Sheri; Akbari, Emis; Jenkins, Jennifer M

    2015-01-01

    At 18 months, children show marked variability in their social-cognitive skill development, and the preponderance of past research has focused on constitutional and contextual factors in explaining this variability. Extending this literature, the current study examined whether cumulative biomedical risk represents another source of variability in social cognition at 18 months. Further, we aimed to determine whether responsive parenting moderated the association between biomedical risk and social cognition. A prospective community birth cohort of 501 families was recruited at the time of the child's birth. Cumulative biomedical risk was measured as a count of 10 prenatal/birth complications. Families were followed up at 18 months, at which point social-cognitive data was collected on children's joint attention, empathy, cooperation, and self-recognition using previously validated tasks. Concurrently, responsive maternal behavior was assessed through observational coding of mother-child interactions. After controlling for covariates (e.g., age, gender, child language, socioeconomic variables), both cumulative biomedical risk and maternal responsivity significantly predicted social cognition at 18 months. Above and beyond these main effects, there was also a significant interaction between biomedical risk and maternal responsivity, such that higher biomedical risk was significantly associated with compromised social cognition at 18 months, but only in children who experienced low levels of responsive parenting. For those receiving comparatively high levels of responsive parenting, there was no apparent effect of biomedical risk on social cognition. This study shows that cumulative biomedical risk may be one source of inter-individual variability in social cognition at 18 months. However, positive postnatal experiences, particularly high levels of responsive parenting, may protect children against the deleterious effects of these risks on social cognition.

  14. Cumulative biomedical risk and social cognition in the second year of life: prediction and moderation by responsive parenting

    Directory of Open Access Journals (Sweden)

    Mark eWade

    2015-04-01

    Full Text Available At 18 months, children show marked variability in their social-cognitive skill development, and the preponderance of past research has focused on constitutional and contextual factors in explaining this variability. Extending this literature, the current study examined whether cumulative biomedical risk represents another source of variability in social cognition at 18 months. Further, we aimed to determine whether responsive parenting moderated the association between biomedical risk and social cognition. A prospective community birth cohort of 501 families was recruited at the time of the child’s birth. Cumulative biomedical risk was measured as a count of 10 prenatal/birth complications. Families were followed up at 18 months, at which point social-cognitive data was collected on children’s joint attention, empathy, cooperation, and self-recognition using previously-validated tasks. Concurrently, responsive maternal behavior was assessed through observational coding of mother-child interactions. After controlling for covariates (e.g. age, gender, child language, socioeconomic variables, both cumulative biomedical risk and maternal responsivity significantly predicted social cognition at 18 months. Above and beyond these main effects, there was also a significant interaction between biomedical risk and maternal responsivity, such that higher biomedical risk was significantly associated with compromised social cognition at 18 months, but only in children who experienced low levels of responsive parenting. For those receiving comparatively high levels of responsive parenting, there was no apparent effect of biomedical risk on social cognition. This study shows that cumulative biomedical risk may be one source of inter-individual variability in social cognition at 18 months. However, positive postnatal experiences, particularly high levels of responsive parenting, may protect children against the deleterious effects of these risks on social

  15. Linking turbine collision risks with population models to assess cumulative impacts of multiple wind farms on threatened birds

    Energy Technology Data Exchange (ETDEWEB)

    Smales, Ian; Muir, Stuart; Meredith, Charles; Baird, Robert

    2011-07-01

    Full text: Assessment of the effects on birds of wind turbine collisions has generally been focussed on the number of individuals that might be killed at a particular facility. However, this measure, of itself, may have little relevance to evaluating the potential or real effects on conservation status of threatened species. Determination of the overall effect any such mortality may have on the functioning of these populations will provide a better basis for decisions that have a strong foundation in ecology. For species with sufficient demographic information, we have developed and applied an approach combining collision risk modelling for all wind farms within the range of a threatened species with population modelling. This permits population-level evaluation of potential cumulative impacts of multiple wind farms. In Australia, regulatory authorities are increasingly interested in the cumulative risk to threatened species that may be posed by multiple wind energy facilities within a species. range. The approach outlined here has been applied in the pre-construction approval stage using collision risk modelling, and can be applied to operational facilities using data on actual mortalities. Cumulative modelling of risk posed by multiple wind farms requires different approaches for sedentary and migratory species. For sedentary species the cumulative effect will be the sum of the impact experienced by those parts of the population whose range intersects with wind farms. Cumulative impact is derived for migratory species by assessing the probability of birds surviving encounters with one wind farm after another on the migratory route and is thus the product of their survivorship rates for the relevant wind farms. The collision risk modelling used will be outlined along with the method in which it is integrated with a population model. Case studies for a crane (Brolga Grus rubicundus) and a parrot (orange- bellied parrot Neophema chrysogaster) species will be

  16. Relations of Growth in Effortful Control to Family Income, Cumulative Risk, and Adjustment in Preschool-age Children

    OpenAIRE

    Lengua, Liliana J.; Moran, Lyndsey; Zalewski, Maureen; Ruberry, Erika; Kiff, Cara; Thompson, Stephanie

    2015-01-01

    The study examined growth in effortful control (executive control, delay ability) in relation to income, cumulative risk (aggregate of demographic and psychosocial risk factors), and adjustment in 306 preschool-age children (50% girls, 50% boys) from families representing a range of income (29% at- or near-poverty; 28% lower-income; 25% middle-income; 18% upper-income), with 4 assessments starting at 36–40 mos. Income was directly related to levels of executive control and delay ability. Cumu...

  17. Relations of growth in effortful control to family income, cumulative risk, and adjustment in preschool-age children.

    Science.gov (United States)

    Lengua, Liliana J; Moran, Lyndsey; Zalewski, Maureen; Ruberry, Erika; Kiff, Cara; Thompson, Stephanie

    2015-05-01

    The study examined growth in effortful control (executive control, delay ability) in relation to income, cumulative risk (aggregate of demographic and psychosocial risk factors), and adjustment in 306 preschool-age children (50 % girls, 50 % boys) from families representing a range of income (29 % at- or near-poverty; 28 % lower-income; 25 % middle-income; 18 % upper-income), with 4 assessments starting at 36-40 month. Income was directly related to levels of executive control and delay ability. Cumulative risk accounted for the effects of income on delay ability but not executive control. Higher initial executive control and slope of executive control and delay ability predicted academic readiness, whereas levels, but not growth, of executive control and delay ability predicted social competence and adjustment problems. Low income is a marker for lower effortful control, which demonstrates additive or mediating effects in the relation of income to children's preschool adjustment.

  18. Cumulative radiation exposure and cancer risk of patients with ischemic heart diseases from diagnostic and therapeutic imaging procedures

    Energy Technology Data Exchange (ETDEWEB)

    Brix, Gunnar, E-mail: gbrix@bfs.de [Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingoldstädter Landstraße 1, D-85764 Oberschleissheim (Germany); Berton, Marc, E-mail: marcberton@web.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Nekolla, Elke, E-mail: enekolla@bfs.de [Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingoldstädter Landstraße 1, D-85764 Oberschleissheim (Germany); Lechel, Ursula, E-mail: ulechel@bfs.de [Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingoldstädter Landstraße 1, D-85764 Oberschleissheim (Germany); Schegerer, Alexander, E-mail: aschegerer@bfs.de [Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingoldstädter Landstraße 1, D-85764 Oberschleissheim (Germany); Süselbeck, Tim, E-mail: Tim.Sueselbeck@umm.de [Department of Cardiology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Fink, Christian, E-mail: Christian.Fink@umm.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany)

    2013-11-01

    Objectives: To present a detailed analysis of the cumulative radiation exposure and cancer risk of patients with ischemic heart diseases (IHD) from diagnostic and therapeutic imaging. Methods: For 1219 IHD patients, personal and examination data were retrieved from the information systems of a university hospital. For each patient, cumulative organ doses and the corresponding effective dose (E{sup ¯}) resulting from all imaging procedures performed within 3 months before and 12 months after the date of the diagnosis were calculated. The cumulative lifetime attributable risk (LAR{sup ¯}) of the patients to be diseased by radiation-related cancer was estimated using sex-, age-, and organ-specific risk models. Results: Among the 3870 procedures performed in the IHD patients, the most frequent were radiographic examinations (52.4%) followed by coronary catheter angiographies and percutaneous cardiac interventions (41.3%), CT scans (3.9%), and perfusion SPECT (2.3%). 87% of patient exposure resulted from heart catheter procedures. E{sup ¯} and LAR{sup ¯} were significantly higher in males than females (average, 13.3 vs. 10.3 mSv and 0.09 vs. 0.07%, respectively). Contrary to the effective dose, the cancer risk decreased markedly for both sexes with increasing age. Conclusions: Although IHD patients were partially exposed to considerable amounts of radiation, estimated LAR{sup ¯}s were small as compared to their baseline risk to develop cancer in the remaining life.

  19. Cumulative Psychosocial and Medical Risk as Predictors of Early Infant Development and Parenting Stress in an African-American Preterm Sample

    Science.gov (United States)

    Candelaria, Margo A.; O'Connell, Melissa A.; Teti, Douglas M.

    2006-01-01

    The present study examined predictive linkages between cumulative psychosocial and medical risk, assessed neonatally, and infant development and parenting stress at 4 months of infant corrected age. Predominantly low-income, African-American mothers and their preterm infants served as participants. Cumulative psychosocial risk predicted early…

  20. Psychobiology of cumulative trauma: hair cortisol as a risk marker for stress exposure in women.

    Science.gov (United States)

    Morris, Matthew C; Abelson, James L; Mielock, Alyssa S; Rao, Uma

    2017-07-01

    Childhood trauma (CT) is associated with long-lasting alterations of the hypothalamic-pituitary-adrenal (HPA) axis and elevated risk for stress exposure in adulthood. Although HPA alterations are present in the early aftermath of trauma, it remains unclear how initial HPA activity is associated with subsequent stress exposure and whether CT exposure influences the strength and direction of this association. The present study examined prospective associations between hair cortisol content (HCC) and stress exposure from baseline to 3-month follow-up in young adult women with recent (i.e. past 3 months) exposure to interpersonal violence (IPV; i.e. physical or sexual assault) and non-traumatized controls. History of significant CT abuse or neglect was determined based on clinical cutoffs for a self-report CT measure: 12 women had abuse or neglect and recent IPV exposure (CT + IPV); 7 women had abuse or neglect but no IPV exposure (CT); 15 women had no history of trauma (NTC). HCC was computed for 3 cm sections reflecting cortisol secretion during the 3 months preceding the baseline assessment. The interaction of cumulative trauma and HCC predicted stress exposure over 3-month follow-up, controlling for baseline stress exposure and depressive symptoms. Simple slopes analyses revealed that lower baseline HCC predicted greater stress exposure in the CT + IPV group compared to the CT group; HCC was not associated with stress exposure in the NTC group. The present findings highlight the potential utility of HCC as a predictor of stress exposure for women with a history of childhood abuse or neglect, particularly in the context of recent IPV. Lay summary Adults with a history of CT show long-lasting alterations in major stress response systems, including the HPA axis. They are also more likely to experience stressful life events in adulthood. However, it is not clear how altered HPA activity influences risk for stress exposure and whether CT affects their

  1. Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia

    Directory of Open Access Journals (Sweden)

    Pablo Serrano-Fernandez

    2015-01-01

    Full Text Available The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668, already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition. Material and Methods. DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia (166 cases and controls, Latvia (81 cases and controls, Lithuania (123 cases and controls, and Poland (795 cases and controls. Results. Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one (corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample. Conclusions. The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers.

  2. A growing danger: the risks posed by marihuana grow-ops

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, F. [Canadian Electricity Association (Canada)

    2005-02-01

    The proliferation of sophisticated illegal indoor multi-plant marihuana cultivation operations is discussed, focusing primarily on public health and safety issues. Public health issues arise from the high level of molds and pollens caused by high humidity, which can cause asthma, respiratory conditions and allergies, particularly among children, and the likelihood of deadly levels of carbon monoxide build-up resulting from faulty rerouting of the residence's ventilation system. Safety issues discussed are: fires and electrocutions associated with the use of electrical diversions or bipasses to circumvent utility meters, the chemical and electrical hazards involved in investigating and dismantling growing operations, the significant dangers to utility crews who must repair illegal electrical bypasses, injuries by the booby-traps planted to protect the operation from other criminals or law enforcement agents, and the physical danger from the violence, including homicide and assaults, carried out by operators to exert control over production and distribution. Although in general, there is a relaxed attitude towards marihuana use in Canada. there is growing evidence of increasing public concern over large-scale growing operations. Nevertheless, to date operators of grow-ops have been dealt with lightly by the justice system. For example, in British Columbia 11,733 cases have come to the attention of police during the 1997 to 2000 period. Of these about half were dealt with informally (i.e. 'no case' seizures) and 2,255 cases led to at least one offender being convicted. The majority of convictions did not result in custodial dispositions. Only 18 per cent of the cases resulted in prison sentences, the average term being only 4.5 months.

  3. High cumulative insulin exposure : a risk factor of atherosclerosis in type 1 diabetes?

    NARCIS (Netherlands)

    Muis, MJ; Bots, ML; Bilo, HJG; Hoogma, RPLM; Hoekstra, JBL; Grobbee, DE; Stolk, RP

    Background: Since insulin therapy might have an atherogenic effect, we studied the relationship between cumulative insulin dose and atherosclerosis in type 1 diabetes. We have focused on patients with type 1 diabetes instead of type 2 diabetes to minimise the effect of insulin resistance as a

  4. Mechanisms and risk of cumulative impacts to coastal ecosystem services: An expert elicitation approach

    KAUST Repository

    Singh, Gerald G.

    2017-05-23

    Coastal environments are some of the most populated on Earth, with greater pressures projected in the future. Managing coastal systems requires the consideration of multiple uses, which both benefit from and threaten multiple ecosystem services. Thus understanding the cumulative impacts of human activities on coastal ecosystem services would seem fundamental to management, yet there is no widely accepted approach for assessing these. This study trials an approach for understanding the cumulative impacts of anthropogenic change, focusing on Tasman and Golden Bays, New Zealand. Using an expert elicitation procedure, we collected information on three aspects of cumulative impacts: the importance and magnitude of impacts by various activities and stressors on ecosystem services, and the causal processes of impact on ecosystem services. We assessed impacts to four ecosystem service benefits — fisheries, shellfish aquaculture, marine recreation and existence value of biodiversity—addressing three main research questions: (1) how severe are cumulative impacts on ecosystem services (correspondingly, what potential is there for restoration)?; (2) are threats evenly distributed across activities and stressors, or do a few threats dominate?; (3) do prominent activities mainly operate through direct stressors, or do they often exacerbate other impacts? We found (1) that despite high uncertainty in the threat posed by individual stressors and impacts, total cumulative impact is consistently severe for all four ecosystem services. (2) A subset of drivers and stressors pose important threats across the ecosystem services explored, including climate change, commercial fishing, sedimentation and pollution. (3) Climate change and commercial fishing contribute to prominent indirect impacts across ecosystem services by exacerbating regional impacts, namely sedimentation and pollution. The prevalence and magnitude of these indirect, networked impacts highlights the need for

  5. The cumulative risk of false-positive screening results across screening centres in the Norwegian Breast Cancer Screening Program

    Energy Technology Data Exchange (ETDEWEB)

    Roman, M., E-mail: Marta.Roman@kreftregisteret.no [Cancer Registry of Norway, Oslo (Norway); Department of Women and Children’s Health, Oslo University Hospital, Oslo (Norway); Skaane, P., E-mail: PERSK@ous-hf.no [Department of Radiology, Oslo University Hospital Ullevaal, University of Oslo, Oslo (Norway); Hofvind, S., E-mail: Solveig.Hofvind@kreftregisteret.no [Cancer Registry of Norway, Oslo (Norway); Oslo and Akershus University College of Applied Sciences, Faculty of Health Science, Oslo (Norway)

    2014-09-15

    Highlights: • We found variation in early performance measures across screening centres. • Radiologists’ performance may play a key role in the variability. • Potential to improve the effectiveness of breast cancer screening programs. • Continuous surveillance of screening centres and radiologists is essential. - Abstract: Background: Recall for assessment in mammographic screening entails an inevitable number of false-positive screening results. This study aimed to investigate the variation in the cumulative risk of a false positive screening result and the positive predictive value across the screening centres in the Norwegian Breast Cancer Screening Program. Methods: We studied 618,636 women aged 50–69 years who underwent 2,090,575 screening exams (1996–2010. Recall rate, positive predictive value, rate of screen-detected cancer, and the cumulative risk of a false positive screening result, without and with invasive procedures across the screening centres were calculated. Generalized linear models were used to estimate the probability of a false positive screening result and to compute the cumulative false-positive risk for up to ten biennial screening examinations. Results: The cumulative risk of a false-positive screening exam varied from 10.7% (95% CI: 9.4–12.0%) to 41.5% (95% CI: 34.1–48.9%) across screening centres, with a highest to lowest ratio of 3.9 (95% CI: 3.7–4.0). The highest to lowest ratio for the cumulative risk of undergoing an invasive procedure with a benign outcome was 4.3 (95% CI: 4.0–4.6). The positive predictive value of recall varied between 12.0% (95% CI: 11.0–12.9%) and 19.9% (95% CI: 18.3–21.5%), with a highest to lowest ratio of 1.7 (95% CI: 1.5–1.9). Conclusions: A substantial variation in the performance measures across the screening centres in the Norwegian Breast Cancer Screening Program was identified, despite of similar administration, procedures, and quality assurance requirements. Differences in the

  6. The excess risk of major osteoporotic fractures in hypothyroidism is driven by cumulative hyperthyroid as opposed to hypothyroid time

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Jørgensen, Henrik L; Laulund, Anne Sofie

    2015-01-01

    The long-term relationship between hypothyroidism and fracture risk is challenging to dissect because of the modifying influence of subsequent thyroxine replacement with the potential for excessive replacement doses. We studied changes in serum thyrotropin concentration (TSH) over time and associ......The long-term relationship between hypothyroidism and fracture risk is challenging to dissect because of the modifying influence of subsequent thyroxine replacement with the potential for excessive replacement doses. We studied changes in serum thyrotropin concentration (TSH) over time...... as a predictor of fracture risk in postmenopausal women whereas hypothyroid time predicted increased fracture risk in men below age 75 years. In conclusion, among patients who present with an elevated TSH, the long-term risk of hip and other osteoporotic fractures is strongly related to the cumulative duration...

  7. A semi-parametric censoring bias model for estimating the cumulative risk of a false-positive screening test under dependent censoring

    OpenAIRE

    Hubbard, Rebecca A.; Miglioretti, Diana L.

    2013-01-01

    False-positive test results are among the most common harms of screening tests and may lead to more invasive and expensive diagnostic testing procedures. Estimating the cumulative risk of a false-positive screening test result after repeat screening rounds is therefore important for evaluating potential screening regimens. Existing estimators of the cumulative false-positive risk are limited by strong assumptions about censoring mechanisms and parametric assumptions about variation in risk ac...

  8. Cumulative risk on the oxytocin receptor gene (OXTR) underpins empathic communication difficulties at the first stages of romantic love.

    Science.gov (United States)

    Schneiderman, Inna; Kanat-Maymon, Yaniv; Ebstein, Richard P; Feldman, Ruth

    2014-10-01

    Empathic communication between couples plays an important role in relationship quality and individual well-being and research has pointed to the role of oxytocin in providing the neurobiological substrate for pair-bonding and empathy. Here, we examined links between genetic variability on the oxytocin receptor gene (OXTR) and empathic behaviour at the initiation of romantic love. Allelic variations on five OXTR single nucleotide polymorphisms (SNPs) previously associated with susceptibility to disorders of social functioning were genotyped in 120 new lovers: OXTRrs13316193, rs2254298, rs1042778, rs2268494 and rs2268490. Cumulative genetic risk was computed by summing risk alleles on each SNP. Couples were observed in support-giving interaction and behaviour was coded for empathic communication, including affective congruence, maintaining focus on partner, acknowledging partner's distress, reciprocal exchange and non-verbal empathy. Hierarchical linear modelling indicated that individuals with high OXTR risk exhibited difficulties in empathic communication. OXTR risk predicted empathic difficulties above and beyond the couple level, relationship duration, and anxiety and depressive symptoms. Findings underscore the involvement of oxytocin in empathic behaviour during the early stages of social affiliation, and suggest the utility of cumulative risk and plasticity indices on the OXTR as potential biomarkers for research on disorders of social dysfunction and the neurobiology of empathy.

  9. Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

    DEFF Research Database (Denmark)

    Müller, Anne Kirstine; Bosgra, Sieto; Boon, Polly E.;

    2009-01-01

    reproductive endpoints (ano-genital distance, and weights of the seminal vesicles and the musculus levator ani/bulbocavernosus) in male rat foetuses exposed in utero. The cumulative dietary intake was estimated based on consumption data and residue data from the Netherlands. The IPRA model combines variability...... in both exposure and sensitivity between individuals into a distribution of individual margins of exposures (IMoEs) and IMoEs of 1 or less indicate a possible concern. The assessment did not result in IMoEs ≤ 1. The endpoint ‘weight of seminal vesicles’ resulted in the lowest IMoEs (0.1th percentile: 198...

  10. Meta-analysis for aggregated survival data with competing risks: a parametric approach using cumulative incidence functions.

    Science.gov (United States)

    Bonofiglio, Federico; Beyersmann, Jan; Schumacher, Martin; Koller, Michael; Schwarzer, Guido

    2016-09-01

    Meta-analysis of a survival endpoint is typically based on the pooling of hazard ratios (HRs). If competing risks occur, the HRs may lose translation into changes of survival probability. The cumulative incidence functions (CIFs), the expected proportion of cause-specific events over time, re-connect the cause-specific hazards (CSHs) to the probability of each event type. We use CIF ratios to measure treatment effect on each event type. To retrieve information on aggregated, typically poorly reported, competing risks data, we assume constant CSHs. Next, we develop methods to pool CIF ratios across studies. The procedure computes pooled HRs alongside and checks the influence of follow-up time on the analysis. We apply the method to a medical example, showing that follow-up duration is relevant both for pooled cause-specific HRs and CIF ratios. Moreover, if all-cause hazard and follow-up time are large enough, CIF ratios may reveal additional information about the effect of treatment on the cumulative probability of each event type. Finally, to improve the usefulness of such analysis, better reporting of competing risks data is needed. Copyright © 2015 John Wiley & Sons, Ltd.

  11. Understanding the Relation of Low Income to HPA-Axis Functioning in Preschool Children: Cumulative Family Risk and Parenting As Pathways to Disruptions in Cortisol

    OpenAIRE

    Zalewski, Maureen; Lengua, Liliana J.; Kiff, Cara J.; Fisher, Philip A.

    2012-01-01

    This study examined the relation of low income and poverty to cortisol levels, and tested potential pathways from low income to disruptions in cortisol through cumulative family risk and parenting. The sample of 306 mothers and their preschool children included 29 % families at or near poverty, 27 % families below the median income, and the remaining families at middle and upper income. Lower income was related to lower morning cortisol levels, and cumulative risk predicted a flatter diurnal ...

  12. Lifetime cumulative risk factors predict cardiovascular disease mortality in a 50-year follow-up study in Finland.

    Science.gov (United States)

    Reinikainen, Jaakko; Laatikainen, Tiina; Karvanen, Juha; Tolonen, Hanna

    2015-02-01

    Systolic blood pressure, total cholesterol and smoking are known predictors of cardiovascular disease (CVD) mortality. Less is known about the effect of lifetime accumulation and changes of risk factors over time as predictors of CVD mortality, especially in very long follow-up studies. Data from the Finnish cohorts of the Seven Countries Study were used. The baseline examination was in 1959 and seven re-examinations were carried out at approximately 5-year intervals. Cohorts were followed up for mortality until the end of 2011. Time-dependent Cox models with regular time-updated risk factors, time-dependent averages of risk factors and latest changes in risk factors, using smoothing splines to discover nonlinear effects, were used to analyse the predictive effect of risk factors for CVD mortality. A model using cumulative risk factors, modelled as the individual-level averages of several risk factor measurements over time, predicted CVD mortality better than a model using the most recent measurement information. This difference seemed to be most prominent for systolic blood pressure. U-shaped effects of the original predictors can be explained by partitioning a risk factor effect between the recent level and the change trajectory. The change in body mass index predicted the risk although body mass index itself did not. The lifetime accumulation of risk factors and the observed changes in risk factor levels over time are strong predictors of CVD mortality. It is important to investigate different ways of using the longitudinal risk factor measurements to take full advantage of them. © The Author 2014; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

  13. Cumulative risk and AIDS-orphanhood: interactions of stigma, bullying and poverty on child mental health in South Africa.

    Science.gov (United States)

    Cluver, Lucie; Orkin, Mark

    2009-10-01

    Research shows that AIDS-orphaned children are more likely to experience clinical-range psychological problems. Little is known about possible interactions between factors mediating these high distress levels. We assessed how food insecurity, bullying, and AIDS-related stigma interacted with each other and with likelihood of experiencing clinical-range disorder. In South Africa, 1025 adolescents completed standardised measures of depression, anxiety and post-traumatic stress. 52 potential mediators were measured, including AIDS-orphanhood status. Logistic regressions and hierarchical log-linear modelling were used to identify interactions among significant risk factors. Food insecurity, stigma and bullying all independently increased likelihood of disorder. Poverty and stigma were found to interact strongly, and with both present, likelihood of disorder rose from 19% to 83%. Similarly, bullying interacted with AIDS-orphanhood status, and with both present, likelihood of disorder rose from 12% to 76%. Approaches to alleviating psychological distress amongst AIDS-affected children must address cumulative risk effects.

  14. Phthalates in Commercial Chinese Rice Wines: Concentrations and the Cumulative Risk Assessment to Adult Males in Shanghai.

    Science.gov (United States)

    Huang, Yue; Lu, Wen Wei; Chen, Bo; You, Jie; Wu, Min; Li, Shu Guang

    2014-10-01

    The concentrations of 16 phthalates in 164 commercial Chinese rice wines (CRW) were detected by GC-MS, and consumption data on CRW in different packaging types was investigated from 634 adult males in Shanghai using a food frequency questionnaire. Based on the principles of probabilistic modelling and cumulative risk assessment, the exposure and health risk of phthalates from CRW to adult males in Shanghai was evaluated. DMP, DEP, DIBP, DnBP, BBP, and DEHP were detected in the samples, the range of detection frequency of individual phthalates varied from 6.10% for BBP to 15.24% for DIBP, and the detected concentrations were 51.06-200.34 ng/mL. All the respondents consumed CRW, 90.69% of them consumed CRW 0.01-49.9 mL/d, the minimum value of the average daily intake of CRW was 6.25 mL/d, the median was 13.72 mL/d and the maximum was 300 mL/d. The median exposure level of the 6 detected Phthalates to adult males in Shanghai were 6.58-7.10 ng/(d•kg), and the maximum exposure level were 137.38-540.47 ng/(d•kg). The cumulative exposure health risk index (HI) based on the median and maximum exposure level of the 6 Phthalates (DMP, DEP, DIBP, DnBP, BBP, and DEHP) were 0.001147 and 0.063396, both were far less than 1. In conclusion, CRW were generally consumed by the adult males in Shanghai, although multiple phthalates were detected in commercial CRW, health risk of such exposure levels from commercial CRW to the target adult males in Shanghai was very low.

  15. Measuring the Combined Risk to Young Children's Cognitive Development: An Alternative to Cumulative Indices

    Science.gov (United States)

    Hall, James E.; Sammons, Pam; Sylva, Kathy; Melhuish, Edward; Taggart, Brenda; Siraj-Blatchford, Iram; Smees, Rebecca

    2010-01-01

    In studies of child development, the combined effect of multiple risks acting in unison has been represented in a variety of ways. This investigation builds upon this preceding work and presents a new procedure for capturing the combined effect of multiple risks. A representative sample of 2,899 British children had their cognitive development…

  16. The use of modelling and probabilistic methods in cumulative risk assessment

    NARCIS (Netherlands)

    Bosgra, S.

    2008-01-01

    This thesis was realized as part of the EU integrated project SAFE FOODS, the overall objective of which was to change the scope of decision-making on food safety from single risks to considering foods as sources of risks, benefits and costs associated with their production and consumption, and taki

  17. Cumulative Risk for Early Sexual Initiation among American Indian Youth: A Discrete-Time Survival Analysis

    Science.gov (United States)

    Mitchell, Christina M.; Whitesell, Nancy Rumbaugh; Spicer, Paul; Beals, Janette; Kaufman, Carol E.

    2007-01-01

    Approximately 3 million teens are diagnosed with a sexually transmitted disease (STD) annually; STDs rates for American Indian young adults are among the highest of any racial/ethnic group. An important risk factor for STDs is early initiation of sex. In this study, we examined risk for early initiation with 474 American Indian youth ages 14-18,…

  18. Cumulative Effects of Mothers' Risk and Promotive Factors on Daughters' Disruptive Behavior

    Science.gov (United States)

    van der Molen, Elsa; Hipwell, Alison E.; Vermeiren, Robert; Loeber, Rolf

    2012-01-01

    Little is known about the ways in which the accumulation of maternal factors increases or reduces risk for girls' disruptive behavior during preadolescence. In the current study, maternal risk and promotive factors and the severity of girls' disruptive behavior were assessed annually among girls' ages 7-12 in an urban community sample (N = 2043).…

  19. Cumulative years in occupation and the risk of hip or knee osteoarthritis in men and women

    DEFF Research Database (Denmark)

    Andersen, Susan; Thygesen, Lau Caspar; Davidsen, Michael

    2012-01-01

    Occupational workload has been associated with an increased risk of osteoarthritis (OA), but only little research has been conducted among female workers. The objective of this study was to analyse if men and women in farming, construction or healthcare work have increased risk of developing OA...

  20. 78 FR 25440 - Request for Information and Citations on Methods for Cumulative Risk Assessment

    Science.gov (United States)

    2013-05-01

    ..., social sciences, dose response modeling and statistics (among others); and may also include addressing... understanding risk from multiple stressors, and that EPA had begun to address approaches to CRA. The NRC and EPA..., multi-stressor approaches to understanding risks to human health and the environment. For example, in...

  1. Salmonellabeheersing op maat

    NARCIS (Netherlands)

    Gaag, van der M.; Mul, M.F.

    2003-01-01

    Om vleesvarkenshouders te helpen om Salmonella op het bedrijf te beheersen zijn acht checklisten ontwikkeld. Hiermee kunnen de bedrijfsspecifieke beheersmaatregelen op gestructureerde wijze bepaald worden

  2. The Association between Cumulative Psychosocial Risk and Cervical HPV Infection Among Female Adolescents in a Free Vaccination Program

    Science.gov (United States)

    Linares, Lourdes Oriana; Shankar, Viswanathan; Diaz, Angela; Nucci-Sack, Anne; Strickler, Howard D.; Peake, Ken; Weiss, Jocelyn; Burk, Robert D.; Schlecht, Nicolas F.

    2016-01-01

    Objective This study investigated the association of cervical Human Papillomavirus (HPV) infection with cumulative psychosocial risk reflecting family disadvantage, psychological distress, and unhealthy life style. Methods The sample (N=745) was comprised of sexually-active female adolescent patients (12-19 years), primarily ethnic minorities, enrolled in a free HPV vaccination program. Subjects completed questionnaires and provided cervical swabs for HPV DNA testing. Unweighted and weighted Principal Component Analyses (PCA) for categorical data were used to derive multi-systemic psychosocial risk indices using nine indicators: low socioeconomic status, lack of adult involvement, not attending high-school/college, history of treatment for depression/anxiety, antisocial/delinquent behavior, number of recent sexual partners, use of alcohol, use of drugs, and dependency risk for alcohol/drugs. The association between cervical HPV (any-type, high risk-types, vaccine-types) assayed by polymerase chain reaction and self-reported number of psychosocial risk indicators was estimated using multivariable logistic regression. Results Subjects had a median of three psychosocial risk indicators. Multiple logistic regression analyses showed associations with unweighted and weighted number of psychosocial indicators for HPV any-type (adjusted odds ratio [aOR]=1.1; 95% confidence interval [CI]: 1.0-1.2 ); with the strongest associations between weighted drug/alcohol use, drug/alcohol dependency risk, and antisocial/delinquent behavior and detection of HPV vaccine-types (aOR=1.5; 95%CI: 1.1-2.0) independent of number of recent sexual partners and vaccine dose (0-3). Conclusion Increased HPV infections including HPV vaccine-types were associated with greater number of psychosocial risk indicators even after controlling for demographics, sexual behavior, history of chlamydia, and vaccine dose. PMID:25985216

  3. Metals in residential soils and cumulative risk assessment in Yaqui and Mayo agricultural valleys, northern Mexico.

    Science.gov (United States)

    Meza-Montenegro, Maria M; Gandolfi, A Jay; Santana-Alcántar, María Ernestina; Klimecki, Walter T; Aguilar-Apodaca, María Guadalupe; Del Río-Salas, Rafael; De la O-Villanueva, Margarita; Gómez-Alvarez, Agustín; Mendivil-Quijada, Héctor; Valencia, Martín; Meza-Figueroa, Diana

    2012-09-01

    This investigation examines the extent of soil metal pollution associated with the Green Revolution, relative to agricultural activities and associated risks to health in the most important agricultural region of Mexico. Metal contents in bulk soil samples are commonly used to assess contamination, and metal accumulations in soils are usually assumed to increase with decreasing particle size. This study profiled the spatial distribution of metals (Ni, Cr, Pb, Cu, Fe, Cd, V, Hg, Co, P, Se, and Mn) in bulk soil and fine-grained fractions (soil-derived dust) from 22 towns and cities. The contamination of soil was assessed through the use of a geoaccumulation index (Igeo) and pollution index (PI). The results of this study indicated that a number of towns and cities are moderately to highly polluted by soil containing Be, Co, Hg, P, S, V, Zn, Se, Cr, and Pb in both size fractions (coarse and fine). Hazard index in fine fraction (HI(children)=2.1) shows that risk assessment based on Co, Mn, V, and Ni spatially related to power plants, have the potential to pose health risks to local residents, especially children. This study shows that risk assessment based on metal content in bulk soil could be overestimated when compared to fine-grained fraction. Our results provide important information that could be valuable in establishing risk assessment associated with residential soils within agricultural areas, where children can ingest and inhale dust. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. Smoking and the risk of systemic lupus erythematosus: an updated systematic review and cumulative meta-analysis.

    Science.gov (United States)

    Jiang, Fan; Li, Suyun; Jia, Chongqi

    2015-11-01

    Published articles reported controversial results about the association of smoking with the risk of systemic lupus erythematosus (SLE). A meta-analysis was performed to assess the aforementioned association and arrive at a more precise estimate of effect. A comprehensive search was performed to identify case-control or cohort studies (from 1990 to 2015) of the aforementioned association. The I (2) statistic was used to examine between-study heterogeneity. Fixed or random effect model was selected based on heterogeneity test among studies. Publication bias was estimated using Egger's regression asymmetry test. A total of 12 published articles with 13 studies were finally included in our meta-analysis. Results showed that the pooled odds ratio (OR) for SLE risk was 1.56 (95% confidence interval (CI) = 1.26-1.95) among current smokers compared with nonsmokers. For ex-smokers versus nonsmokers, the pooled OR for SLE risk was 1.23 (95% CI = 0.93-1.63). Subgroup analysis by geographic location and cumulative meta-analysis were also analyzed. In conclusion, our meta-analysis suggested that smoking increased the risk of SLE. Further studies are needed to confirm this result.

  5. Single-compound and cumulative risk assessment of mycotoxins present in breakfast cereals consumed by children from Lisbon region, Portugal.

    Science.gov (United States)

    Assunção, Ricardo; Vasco, Elsa; Nunes, Baltazar; Loureiro, Susana; Martins, Carla; Alvito, Paula

    2015-12-01

    Humans can be exposed to multiple chemicals, but current risk assessment is usually carried out on one chemical at a time. Mycotoxins are commonly found in a variety of foods including those intended to consumption by children namely breakfast cereals. The present study aims to perform, the risk assessment of single and multiple mycotoxins present in breakfast cereals consumed by children (1-3 years old) from Lisbon region, Portugal. Daily exposure of children to ochratoxin A, fumonisins and trichothecenes showed no health risks to the children population considering individual mycotoxins, while exposure to aflatoxin B1 (AFB1) suggested a potential health concern for the high percentiles of intake (P90, P95 and P99). The combined exposure to fumonisins and trichothecenes are not expected to be of health concern. The combined margin of exposure (MoET) for the aflatoxins group could constitute a potential health concern and AFB1 was the main contributor for MoET. Legal limits and control strategies regarding the presence of multiple mycotoxins in foodstuffs is an urgent need. To the best of our knowledge, this is the first time a cumulative risk assessment was performed on multiple mycotoxins present in breakfast cereals consumed by children.

  6. Tsunami, War, and Cumulative Risk in the Lives of Sri Lankan Schoolchildren

    Science.gov (United States)

    Catani, Claudia; Gewirtz, Abigail H.; Wieling, Elizabeth; Schauer, Elizabeth; Elbert, Thomas; Neuner, Frank

    2010-01-01

    This study examines the impact of children's exposure to natural disaster against the backdrop of exposure to other traumatic events and psychosocial risks. One thousand three hundred ninety-eight Sri Lankan children aged 9-15 years were interviewed in 4 cross-sectional studies about exposure to traumatic life events related to the war, the…

  7. Tsunami, War, and Cumulative Risk in the Lives of Sri Lankan Schoolchildren

    Science.gov (United States)

    Catani, Claudia; Gewirtz, Abigail H.; Wieling, Elizabeth; Schauer, Elizabeth; Elbert, Thomas; Neuner, Frank

    2010-01-01

    This study examines the impact of children's exposure to natural disaster against the backdrop of exposure to other traumatic events and psychosocial risks. One thousand three hundred ninety-eight Sri Lankan children aged 9-15 years were interviewed in 4 cross-sectional studies about exposure to traumatic life events related to the war, the…

  8. Cumulative Risk Effects in the Bullying of Children and Young People with Autism Spectrum Conditions

    Science.gov (United States)

    Hebron, Judith; Oldfield, Jeremy; Humphrey, Neil

    2017-01-01

    Students with autism are more likely to be bullied than their typically developing peers. However, several studies have shown that their likelihood of being bullied increases in the context of exposure to certain risk factors (e.g. behaviour difficulties and poor peer relationships). This study explores vulnerability to bullying from a cumulative…

  9. Multilevel Mediation: Cumulative Contextual Risk, Maternal Differential Treatment, and Children's Behavior within Families

    Science.gov (United States)

    Meunier, Jean Christophe; Boyle, Michael; O'Connor, Thomas G.; Jenkins, Jennifer M.

    2013-01-01

    This study tests the hypothesis that links between contextual risk and children's outcomes are partially explained by differential parenting. Using multi-informant measurement and including up to four children per family (M[subscript age] = 3.51, SD = 2.38) in a sample of 397 families, indirect effects (through maternal differential…

  10. Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

    Science.gov (United States)

    Chang, Jung-Wei; Lee, Ching-Chang; Pan, Wen-Harn; Chou, Wei-Chun; Huang, Han-Bin; Chiang, Hung-Che; Huang, Po-Chin

    2017-03-01

    A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan’s general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQrep) and hepatic (HQhep) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95th percentile (P95) of HQrep values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQhep values were all >1 in the 7- to 18- year-old male groups. Most of the HQrep was attributable to the HQs of DnBP and DiBP (53.9–84.7%), and DEHP contributed most to HQhep (83.1–98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan’s general population is widely exposed to DnBP, DiBP and DEHP, especially for young children.

  11. Risk of therapy-related leukaemia and preleukaemia after Hodgkin's disease. Relation to age, cumulative dose of alkylating agents, and time from chemotherapy

    DEFF Research Database (Denmark)

    Pedersen-Bjergaard, J; Specht, L; Larsen, S O;

    1987-01-01

    391 patients treated intensively for Hodgkin's disease were followed for up to 15 years to evaluate the risk of therapy-related acute non-lymphocytic leukaemia (t-ANLL) and preleukaemia. Only two independent factors, patient age and cumulative dose of alkylating agents, were related to the risk o...

  12. A comparison of peak vs cumulative physical work exposure risk factors for the reporting of low back pain in the automotive industry.

    Science.gov (United States)

    Norman, R.; Wells, R.; Neumann, P.; Frank, J.; Shannon, H.; Kerr, M.

    1998-12-01

    OBJECTIVE: To determine the relative importance of modelled peak spine loads, hand loads, trunk kinematics and cumulative spine loads as predictors of reported low back pain (LBP). BACKGROUND: The authors have recently shown that both biomechemical and psychosocial variables are important in the reporting of LBP. In previous studies, peak spinal load risk factors have been identified and while there is in vitro evidence for adverse effects of excessive cumulative load on tissue, there is little epidemiological evidence. METHODS: Physical exposures to peak and cumulative lumbar spine moment, compression and shear forces, trunk kinematics, and forces on hands were analyzed on 130 randomly selected controls and 104 cases. Univariable and multivariable odds ratios of the risk of reporting were calculated from a backwards logistic regression analysis. Interrelationships among variables were examined by factor analysis. RESULTS: Cases showed significantly higher loading on all biomechanical variables. Four independent risk factors were identified: integrated lumbar moment (over a shift), 'usual' hand force, peak shear force at the level of L(4)/L(5) and peak trunk velocity. Substituting lumbar compression or moment for shear did not appreciably alter odds ratios because of high correlations among these variables. CONCLUSIONS: Cumulative biomechanical variables are important risk factors in the reporting of LBP. Spinal tissue loading estimates from a biomechanical model provide information not included in the trunk kinematics and hand force inputs to the model alone. Workers in the top 25% of loading exposure on all risk factors are at about six times the risk of reporting LBP when compared with those in the bottom 25%. RELEVANCE: Primary prevention, treatment, and return to work efforts for individuals reporting LBP all require understanding of risk factors. The results suggest that cumulative loading of the low back is important etiologically and highlight the need for

  13. Urinary antibiotics of pregnant women in Eastern China and cumulative health risk assessment.

    Science.gov (United States)

    Wang, Hexing; Wang, Na; Qian, Junhua; Hu, Lingyun; Huang, Peixin; Su, Meifang; Yu, Xin; Fu, Chaowei; Jiang, Feng; Zhao, Qi; Zhou, Ying; Lin, Haijiang; He, Gengsheng; Chen, Yue; Jiang, Qingwu

    2017-02-23

    Exposure to antibiotics during pregnancy can pose a systematic effect on human health. A few bio-monitoring studies have demonstrated an extensive exposure of children to antibiotics, but there is still lack of data for pregnant women. To assess the exposure of pregnant women to antibiotics and potential health risk, we investigated 536 pregnant women aged 16-42 years from two geographically different study sites in Eastern China in 2015. We measured 21 antibiotics of five categories (seven fluoroquinolones, three phenicols, four tetracyclines, three macrolides, and four sulfonamides) in urines by using the isotope dilution ultra-performance liquid chromatography coupled to quadrupole time of-flight mass spectrometry. Hazard index (HI) was calculated based on estimated daily exposure dose and acceptable daily intakes. Sixteen antibiotics were found in urines with detection frequencies between 0.2% and 16.0%. Antibiotics were overall detected in 41.6% of urines, and two or more antibiotics were detected in 13.1% of urines. Ciprofloxacin, ofloxacin, and trimethoprim were most frequently detected in urine with detection frequencies between 10% and 20%. The majority of the antibiotics tested had an estimated daily exposure dose less than 1μg/kg/day and 4.3% of pregnant women had a HI value more than one. These findings indicated that pregnant women were frequently exposed to antibiotics and some individuals were in the potential risk of adverse microbiological effects induced by antibiotics.

  14. Cumulative contextual risk, maternal responsivity, and social cognition at 18 months.

    Science.gov (United States)

    Wade, Mark; Moore, Chris; Astington, Janet Wilde; Frampton, Kristen; Jenkins, Jennifer M

    2015-02-01

    By 18 months children demonstrate a range of social-cognitive skills that can be considered important precursors to more advanced forms of social understanding such as theory of mind. Although individual differences in social cognition have been linked to neurocognitive maturation, sociocultural models of development suggest that environmental influences operate in the development of children's social-cognitive outcomes. In the current study of 501 children and their mothers, we tested and found support for a model in which distal environmental risk, assessed when children were newborns, was indirectly associated with children's social-cognitive competency at 18 months through mothers' responsivity at 18 months. Part of this effect also operated through children's concomitant language skills, suggesting both a language-mediated and a language-independent mechanism of social-cognitive development. These findings are discussed with respect to the Vygotskian themes of internalization and semiotic mediation.

  15. Understanding the relation of low income to HPA-axis functioning in preschool children: cumulative family risk and parenting as pathways to disruptions in cortisol.

    Science.gov (United States)

    Zalewski, Maureen; Lengua, Liliana J; Kiff, Cara J; Fisher, Philip A

    2012-12-01

    This study examined the relation of low income and poverty to cortisol levels, and tested potential pathways from low income to disruptions in cortisol through cumulative family risk and parenting. The sample of 306 mothers and their preschool children included 29 % families at or near poverty, 27 % families below the median income, and the remaining families at middle and upper income. Lower income was related to lower morning cortisol levels, and cumulative risk predicted a flatter diurnal slope, with a significant indirect effect through maternal negativity, suggesting that parenting practices might mediate an allostatic effect on stress physiology.

  16. Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

    NARCIS (Netherlands)

    Dunlop, Malcolm G.; Tenesa, Albert; Farrington, Susan M.; Ballereau, Stephane; Brewster, David H.; Koessler, Thibaud; Pharoah, Paul; Schafmayer, Clemens; Hampe, Jochen; Voelzke, Henry; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; von Holst, Susanna; Picelli, Simone; Lindblom, Annika; Jenkins, Mark A.; Hopper, John L.; Casey, Graham; Duggan, David; Newcomb, Polly A.; Abuli, Anna; Bessa, Xavier; Ruiz-Ponte, Clara; Castellvi-Bel, Sergi; Niittymaeki, Iina; Tuupanen, Sari; Karhu, Auli; Aaltonen, Lauri; Zanke, Brent; Hudson, Tom; Gallinger, Steven; Barclay, Ella; Martin, Lynn; Gorman, Maggie; Carvajal-Carmona, Luis; Walther, Axel; Kerr, David; Lubbe, Steven; Broderick, Peter; Chandler, Ian; Pittman, Alan; Penegar, Steven; Campbell, Harry; Tomlinson, Ian; Houlston, Richard S.

    2013-01-01

    Objective Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation has been shown to contribute to CRC risk. A study was conducted in a large multi-population study to assess the feasibility of CRC risk prediction using common genetic variant data combined with other r

  17. Ergonomic risk exposure and upper-extremity cumulative trauma disorders in a maquiladora medical devices manufacturing plant.

    Science.gov (United States)

    Meservy, D; Suruda, A J; Bloswick, D; Lee, J; Dumas, M

    1997-08-01

    Workers at a Nogales, Mexico, maquiladora plant that assembles medical devices were studied to determine the prevalence of upper-extremity cumulative trauma disorders (CTD). Subjects included production workers employed 6 months or longer; of the 148 eligible workers, 145 (98%) participated. Subjects had a mean age of 24.6 years (SD = 5.2; range, 17 to 45) and the mean length of employment was 3.5 years (SD = 2.5; range, 0.5 to 14). Job tasks were videotaped and analyzed for ergonomic risk factors, using pre-defined criteria. All jobs performed by study subjects were found to involve one or more ergonomic risk factors associated with the development of CTD. A CTD questionnaire and screening physical examination format, similar to that used by the National Institute of Occupational Safety and Health (NIOSH) in a chicken processing plant study, were administered. Period prevalence of CTD within the previous year, as reported on the questionnaire, was 28%. Prevalence of CTD was 17%, using data from the screening physical examination. Point prevalence (current pain data from the questionnaire plus positive symptoms on the screening physical examination) was 15%. CTD was reported more frequently in women than men (46% and 25%, respectively; P < 0.05) and in subjects who had worked at the plant less than one year (50%; P < 0.05). Workforce turnover (3% monthly) may have resulted in those affected by CTD leaving employment, reducing the apparent CTD rate in experienced workers.

  18. CUMULATIVE TRAUMAS AND RISK THRESHOLDS: 12-MONTH PTSD IN THE WORLD MENTAL HEALTH (WMH) SURVEYS

    Science.gov (United States)

    Karam, Elie G.; Friedman, Matthew J.; Hill, Eric D.; Kessler, Ronald C.; McLaughlin, Katie A.; Petukhova, Maria; Sampson, Laura; Shahly, Victoria; Angermeyer, Matthias C.; Bromet, Evelyn J.; de Girolamo, Giovanni; de Graaf, Ron; Demyttenaere, Koen; Ferry, Finola; Florescu, Silvia E.; Haro, Josep Maria; He, Yanling; Karam, Aimee N.; Kawakami, Norito; Kovess-Masfety, Viviane; Medina-Mora, María Elena; Browne, Mark A. Oakley; Posada-Villa, José A.; Shalev, Arieh Y.; Stein, Dan J.; Viana, Maria Carmen; Zarkov, Zahari; Koenen, Karestan C.

    2014-01-01

    Background Clinical research suggests that posttraumatic stress disorder (PTSD) patients exposed to multiple traumatic events (TEs) rather than a single TE have increased morbidity and dysfunction. Although epidemiological surveys in the United States and Europe also document high rates of multiple TE exposure, no population-based cross-national data have examined this issue. Methods Data were analyzed from 20 population surveys in the World Health Organization World Mental Health Survey Initiative (n 51,295 aged 18+). The Composite International Diagnostic Interview (3.0) assessed 12-month PTSD and other common DSM-IV disorders. Respondents with 12-month PTSD were assessed for single versus multiple TEs implicated in their symptoms. Associations were examined with age of onset (AOO), functional impairment, comorbidity, and PTSD symptom counts. Results 19.8% of respondents with 12-month PTSD reported that their symptoms were associated with multiple TEs. Cases who associated their PTSD with four or more TEs had greater functional impairment, an earlier AOO, longer duration, higher comorbidity with mood and anxiety disorders, elevated hyper-arousal symptoms, higher proportional exposures to partner physical abuse and other types of physical assault, and lower proportional exposure to unexpected death of a loved one than cases with fewer associated TEs. Conclusions A risk threshold was observed in this large-scale cross-national database wherein cases who associated their PTSD with four or more TEs presented a more “complex” clinical picture with substantially greater functional impairment and greater morbidity than other cases of PTSD. PTSD cases associated with four or more TEs may merit specific and targeted intervention strategies. Depression and Anxiety 31:130–142, 2014. PMID:23983056

  19. Cumulative traumas and risk thresholds: 12-month PTSD in the World Mental Health (WMH) surveys.

    Science.gov (United States)

    Karam, Elie G; Friedman, Matthew J; Hill, Eric D; Kessler, Ronald C; McLaughlin, Katie A; Petukhova, Maria; Sampson, Laura; Shahly, Victoria; Angermeyer, Matthias C; Bromet, Evelyn J; de Girolamo, Giovanni; de Graaf, Ron; Demyttenaere, Koen; Ferry, Finola; Florescu, Silvia E; Haro, Josep Maria; He, Yanling; Karam, Aimee N; Kawakami, Norito; Kovess-Masfety, Viviane; Medina-Mora, María Elena; Browne, Mark A Oakley; Posada-Villa, José A; Shalev, Arieh Y; Stein, Dan J; Viana, Maria Carmen; Zarkov, Zahari; Koenen, Karestan C

    2014-02-01

    Clinical research suggests that posttraumatic stress disorder (PTSD) patients exposed to multiple traumatic events (TEs) rather than a single TE have increased morbidity and dysfunction. Although epidemiological surveys in the United States and Europe also document high rates of multiple TE exposure, no population-based cross-national data have examined this issue. Data were analyzed from 20 population surveys in the World Health Organization World Mental Health Survey Initiative (n = 51,295 aged 18+). The Composite International Diagnostic Interview (3.0) assessed 12-month PTSD and other common DSM-IV disorders. Respondents with 12-month PTSD were assessed for single versus multiple TEs implicated in their symptoms. Associations were examined with age of onset (AOO), functional impairment, comorbidity, and PTSD symptom counts. 19.8% of respondents with 12-month PTSD reported that their symptoms were associated with multiple TEs. Cases who associated their PTSD with four or more TEs had greater functional impairment, an earlier AOO, longer duration, higher comorbidity with mood and anxiety disorders, elevated hyperarousal symptoms, higher proportional exposures to partner physical abuse and other types of physical assault, and lower proportional exposure to unexpected death of a loved one than cases with fewer associated TEs. A risk threshold was observed in this large-scale cross-national database wherein cases who associated their PTSD with four or more TEs presented a more "complex" clinical picture with substantially greater functional impairment and greater morbidity than other cases of PTSD. PTSD cases associated with four or more TEs may merit specific and targeted intervention strategies. © 2013 Wiley Periodicals, Inc.

  20. The cumulative incidence of conventional risk factors of cardiovascular disease and their population attributable risk in an Iranian population: The Isfahan Cohort Study

    Directory of Open Access Journals (Sweden)

    Masoumeh Sadeghi

    2014-01-01

    Full Text Available Background: Cardiovascular diseases (CVDs are the leading cause of death in Iran. The present study evaluated the 7-year incidence of CVD risk factors among the participants of Isfahan cohort study (ICS. Materials and Methods: ICS was a longitudinal study on adults over 35 years of age from the urban and rural areas in three counties in central Iran. Data on clinical examination and blood measurements were collected in 2001. Subjects were followed and similar data were collected in 2007. Cumulative incidence was calculated through dividing new cases of each risk factor by the population free of that risk factor at baseline. Incidence proportion was determined for major CVD risk factors including hypertension (HTN, hypercholesterolemia (HC, hypertriglyceridemia (HTg, obesity, diabetes mellitus (DM, metabolic syndrome (MetS, and smoking. Results: A total number of 6323 adults free of CVDs were recruited. After 7 years of follow-up, 3283 individuals were re-evaluated in 2007. The participants′ age was 49.2 ± 10.3 years in 2001 (mean ± SD. The 7-year cumulative incidence of HTN, HC, HTg, overweight, obesity, DM, MetS, and smoking was 22.8%, 37.4%, 28.0%, 26.3%, 7.4%, 9.5%, 23.9%, and 5.9% in men and 22.2%, 55.4%, 33.5%, 35.0%, 18.8%, 11.3%, 36.1%, and 0.7% in women, respectively. Among those with overweight or obesity, 14.7% of men and 7.9% of women decreased their weight up to the normal level. Conclusions: The present study revealed a high incidence of CVD risk factors especially dyslipidemia, obesity, MetS and HTN. Therefore, the application of life-style modification interventions seems necessary.

  1. Risk of therapy-related leukaemia and preleukaemia after Hodgkin's disease. Relation to age, cumulative dose of alkylating agents, and time from chemotherapy

    DEFF Research Database (Denmark)

    Pedersen-Bjergaard, J.; Specht, L.; Larsen, S.O.;

    1987-01-01

    .0% (SE 3.0) at 10 years after which time there were no further cases. Calculated from cessation of therapy with alkylating agents, however, the cumulative risk curve increased steeply during the first 1-2 years then gradually levelled out and no new cases were observed beyond 7 years. With a 15-year...

  2. Understanding the Relation of Low Income to HPA-Axis Functioning in Preschool Children: Cumulative Family Risk and Parenting as Pathways to Disruptions in Cortisol

    Science.gov (United States)

    Zalewski, Maureen; Lengua, Liliana J.; Kiff, Cara J.; Fisher, Philip A.

    2012-01-01

    This study examined the relation of low income and poverty to cortisol levels, and tested potential pathways from low income to disruptions in cortisol through cumulative family risk and parenting. The sample of 306 mothers and their preschool children included 29 % families at or near poverty, 27 % families below the median income, and the…

  3. Understanding the Relation of Low Income to HPA-Axis Functioning in Preschool Children: Cumulative Family Risk and Parenting as Pathways to Disruptions in Cortisol

    Science.gov (United States)

    Zalewski, Maureen; Lengua, Liliana J.; Kiff, Cara J.; Fisher, Philip A.

    2012-01-01

    This study examined the relation of low income and poverty to cortisol levels, and tested potential pathways from low income to disruptions in cortisol through cumulative family risk and parenting. The sample of 306 mothers and their preschool children included 29 % families at or near poverty, 27 % families below the median income, and the…

  4. Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries : the prospective DIABIMMUNE study

    NARCIS (Netherlands)

    Simre, Kärt; Uibo, Oivi; Peet, Aleksandr; Tillmann, Vallo; Kool, Pille; Hämäläinen, Anu-Maaria; Härkönen, Taina; Siljander, Heli; Virtanen, Suvi; Ilonen, Jorma; Knip, Mikael; Uibo, Raivo; Harmsen, Hermie J.

    2016-01-01

    BACKGROUND: During the last several decades the prevalence of coeliac disease (CD) has increased worldwide. AIM: To compare the cumulative incidence of CD between Estonian and Finnish children and to identify the risk factors. MATERIALS AND METHODS: Children were recruited as part of the DIABIMMUNE

  5. Eikenclusters op de Veluwe

    NARCIS (Netherlands)

    Copini, P.; Buiteveld, J.; Sass, U.G.W.; Ouden, den J.

    2006-01-01

    Op de Veluwe worden op verschillende plekken groepen eiken aangetroffen. Mogelijk behoren ze tot oorspronkelijk inheems materiaal, en zijn ze ontstaan uit hakhout. In dat geval is sprake van een cultureel erfgoed. In opdracht van Gelders Landschap worden momenteel eikenclusters onderzocht op hun ont

  6. Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: case study, Shanghai, China.

    Science.gov (United States)

    Han, Zheng; Nie, Dongxia; Ediage, Emmanuel Njumbe; Yang, Xianli; Wang, Jianhua; Chen, Bo; Li, Shuguang; On, Stephen L W; De Saeger, Sarah; Wu, Aibo

    2014-12-01

    Humans are naturally and frequently exposed to a multitude of mycotoxins, but health risk assessments are usually performed on individual mycotoxins, which may underestimate the total risks. In this study, we assessed for the first time the cumulative health risks of concomitant exposure via dietary intake (DI) to multiple mycotoxins, namely deoxynivalenol (DON) and its acetyl derivatives of 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON), based on the concentration addition (CA) concept. A cross-sectional study was conducted in seven districts in Shanghai, China with 1269 participants and 330 wheat and maize samples analyzed. After probabilistic analysis using Monte Carlo simulation, the results showed no health risks to the population in Shanghai considering individual mycotoxins. However, if the cumulative health risks were calculated based on the combined consideration of DON with either 3-ADON or 15-ADON or both, the DI values in 95th percentile were up to 1087 ng/kg body weight/day, exceeding the Provisional Maximum Tolerable Daily Intake (PMTDI) of 1000 ng/kg body weight/day and hence representing potential health risks to the population in Shanghai. The integrated study proposed here could be a model strategy for cumulative health risk assessment on the co-occurring hazards in the fields of food safety combined with environmental contaminants.

  7. Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8-14 years of age.

    Science.gov (United States)

    Cantoral, A; Téllez-Rojo, M M; Ettinger, A S; Hu, H; Hernández-Ávila, M; Peterson, K

    2016-02-01

    Consumption of sugar-sweetened beverages (SSB) has been associated with risk of obesity, but little evidence exists to evaluate if age of introduction and cumulative SSB consumption increases risk in children. The objective of the study was to estimate the relationship between age of introduction and cumulative SSB consumption with risk of obesity in 227 Mexican children. SSB intake was measured every 6 months; age of introduction and cumulative consumption during the pre-school period were calculated. Height, weight, waist circumference, SSB intake and other relevant variables were measured at age 8-14 years and obesity defined using standard criteria. All participants were introduced to SSB before age 24 months and most (73%) before 12 months. Early SSB introduction (≤12 months) was not significantly associated with increased odds of obesity (odds ratio [OR] = 2.00, 95% confidence interval [CI]: 0.87, 4.59). However, children in the highest tertile of cumulative SSB consumption, compared with the lowest, had almost three times the odds of general (OR = 2.99, 95% CI: 1.27, 7.00) and abdominal (OR = 2.70, 95% CI: 1.03, 7.03) obesity at age 8-14 years. High SSB consumption increased the likelihood of obesity in 8-14-year-old children. Our results suggest that SSB intake should be delayed and excessive SSB consumption in pre-school period should be avoided. © 2015 World Obesity.

  8. Prenatal cocaine exposure: the role of cumulative environmental risk and maternal harshness in the development of child internalizing behavior problems in kindergarten.

    Science.gov (United States)

    Eiden, Rina D; Godleski, Stephanie; Colder, Craig R; Schuetze, Pamela

    2014-01-01

    This study examined the associations between prenatal exposure to cocaine and other substances and child internalizing behavior problems at kindergarten. We investigated whether maternal harshness or cumulative environmental risk mediated or moderated this association. Participants consisted of 216 (116 cocaine exposed, 100 non-cocaine exposed) mother-infant dyads participating in an ongoing longitudinal study of prenatal cocaine exposure. Results indicated that, as hypothesized, maternal harshness moderated the association between prenatal cocaine exposure to child internalizing in kindergarten such that prenatal cocaine exposure increased risk for internalizing problems at high levels of maternal harshness from 7 to 36months and decreased risk at low levels of harshness. Contrary to hypothesis, the association between prenatal cocaine exposure and child internalizing in kindergarten was not mediated by maternal harshness or cumulative environmental risk. However, cumulative environmental risk (from 1month of child age to kindergarten) was predictive of child internalizing behavior problems at kindergarten. Results have implications for parenting interventions that may be targeted toward reducing maternal harshness in high risk samples characterized by maternal substance use in pregnancy.

  9. Long-Term Effects of Prematurity, Cumulative Medical Risk, and Proximal and Distal Social Forces on Individual Differences in Diurnal Cortisol at Young Adulthood.

    Science.gov (United States)

    Winchester, Suzy B; Sullivan, Mary C; Roberts, Mary B; Bryce, Crystal I; Granger, Douglas A

    2017-01-01

    This study examined the effects of prematurity, cumulative medical risk, and proximal and distal social forces on individual differences in the activity of the hypothalamic-pituitary-adrenal (HPA) axis in young adulthood. A prospective sample of 149 infants born healthy preterm (PT; n = 22), sick PT ( n = 93, medical illness, neurological illness, small for gestational age), and full term ( n = 34) was recruited from a Level III neonatal intensive care unit in southern New England between 1985 and 1989 and followed to age 23 years. Cumulative medical risk was indexed across seven assessment waves (spanning 17 years) using medical and neurological health status at birth, toddlerhood (ages 18 and 30 months), childhood (ages 4 and 8 years), and adolescence (ages 12 and 17 years). Distal risk included socioeconomic status (SES) at birth. Proximal social factors were indexed from assessments of the home environment and measures of child vulnerability and maternal self-esteem, involvement, and control style from birth, 4 years, 8 years, and 12 years. At age 23 years, five saliva samples were collected upon awakening, 45 min after waking, 4 hr after waking, 8 hr after waking, and bedtime (later assayed for cortisol). Results reveal effects of cumulative medical risk on the diurnal pattern of HPA axis activity, with moderating effects of SES and proximal social factors. Findings are discussed in terms of implications for contemporary theories related to developmental sensitivity and susceptibility to context and the developmental origins of health and disease theory.

  10. Cumulative Risk Assessment and Environmental Equity in Air Permitting: Interpretation, Methods, Community Participation and Implementation of a Unique Statute

    Directory of Open Access Journals (Sweden)

    Gregory C. Pratt

    2011-11-01

    Full Text Available In 2008, the statute authorizing the Minnesota Pollution Control Agency (MPCA to issue air permits was amended to include a unique requirement to analyze and consider “cumulative levels and effects of past and current environmental pollution from all sources on the environment and residents of the geographic area within which the facility's emissions are likely to be deposited.” Data describing the Statute Area suggest it is challenged by environmental and socioeconomic concerns, i.e., concerns which are often described by the phrase ‘environmental equity’. With input from diverse stakeholders, the MPCA developed a methodology for implementing a cumulative levels and effects analysis when issuing air permits in the designated geographic area. A Process Document was created defining explicit steps a project proposer must complete in the analysis. An accompanying Reference Document compiles all available environmental health data relevant to the Statute Area that could be identified. The final cumulative levels and effects methodology is organized by health endpoint and identifies hazard, exposure and health indices that require further evaluation. The resulting assessment is summarized and presented to decision makers for consideration in the regulatory permitting process. We present a description of the methodology followed by a case study summary of the first air permit processed through the “cumulative levels and effects analysis”.

  11. Cumulative risk assessment and environmental equity in air permitting: interpretation, methods, community participation and implementation of a unique statute.

    Science.gov (United States)

    Ellickson, Kristie M; Sevcik, Sarah M; Burman, Shelley; Pak, Steven; Kohlasch, Frank; Pratt, Gregory C

    2011-11-01

    In 2008, the statute authorizing the Minnesota Pollution Control Agency (MPCA) to issue air permits was amended to include a unique requirement to analyze and consider "cumulative levels and effects of past and current environmental pollution from all sources on the environment and residents of the geographic area within which the facility's emissions are likely to be deposited." Data describing the Statute Area suggest it is challenged by environmental and socioeconomic concerns, i.e., concerns which are often described by the phrase 'environmental equity'. With input from diverse stakeholders, the MPCA developed a methodology for implementing a cumulative levels and effects analysis when issuing air permits in the designated geographic area. A Process Document was created defining explicit steps a project proposer must complete in the analysis. An accompanying Reference Document compiles all available environmental health data relevant to the Statute Area that could be identified. The final cumulative levels and effects methodology is organized by health endpoint and identifies hazard, exposure and health indices that require further evaluation. The resulting assessment is summarized and presented to decision makers for consideration in the regulatory permitting process. We present a description of the methodology followed by a case study summary of the first air permit processed through the "cumulative levels and effects analysis".

  12. Zorg op afstand

    NARCIS (Netherlands)

    Schilstra, P.

    2004-01-01

    Zorg op afstand. Onderzoek onder patiënten met de ziekte van Crohn/ colitis ulcerosa naar de tevredenheid met een nieuwe manier van zorgverlening vanuit de Maag- Darm- en Leverafdeling van het Academisch Ziekenhuis Groningen. Sinds oktober 2002 is er op de Maag-, Darm- en Leverafdeling (MDL-afdeling

  13. Zorg op afstand

    NARCIS (Netherlands)

    Schilstra, P.

    2004-01-01

    Zorg op afstand. Onderzoek onder patiënten met de ziekte van Crohn/ colitis ulcerosa naar de tevredenheid met een nieuwe manier van zorgverlening vanuit de Maag- Darm- en Leverafdeling van het Academisch Ziekenhuis Groningen. Sinds oktober 2002 is er op de Maag-, Darm- en Leverafdeling (MDL-afdeling

  14. Wintertarwe op maat bemesten

    NARCIS (Netherlands)

    Timmer, R.D.

    2001-01-01

    In proeven op vier locaties met verschillende tarwerassen onderzocht PPO de werking van de chlorophylmeter, waarmee de groenheid van een tarwegewas wordt vastgesteld en vervolgens daarmee de stikstofbemesting wordt afgestemd op de behoefte. Met het systeem blijkt het goed mogelijk de optimale tweede

  15. Grip op virussen

    OpenAIRE

    Vlugt, van der, R.A.A.; Verbeek, M.; Roenhorst, A.; Botermans, M.; Kock, de, M.J.D.; Schadewijk, van, R.; Miglino, R.; Kormelink, R.; Lent, van, J.W.M.

    2011-01-01

    Aan het begin van het FES-project ‘Versterking infrastructuur plantgezondheid' zijn de belangrijkste knelpunten op plantenvirologisch gebied in Nederland geïnventariseerd. Criteria hierbij waren vooral fytosanitaire status, economisch belang en de behoefte aan betrouwbare detectie- en identificatiemethoden. Op basis hiervan is een prioriteitenlijst opgesteld van de (gereguleerde) virussen uit de volgende virusgroepen: Potyvirussen, Nepovirussen, Tospovirussen en Potexvirussen. Daarnaast werd ...

  16. 国内外累积性环境风险评估研究进展%Research Progress of Cumulative Environmental Risk Assessment at Home and Abroad

    Institute of Scientific and Technical Information of China (English)

    袁鹏; 李文秀; 彭剑峰; 宋永会; 许伟宁

    2015-01-01

    随着环境风险评估的重点由单一源、单一传播途径、单受体转向多来源、多传播途径、多受体的评估,累积性环境风险评估逐渐成为当前研究热点。通过概念辨析和文献调研的方法,综述了美国累积性环境风险评估的发展历史、评估流程,并对国内外累积性环境风险评估方法、应用研究进展进行了评述。指出了目前国内开展累积性环境风险评估存在的方法不完善、基础科研工作不足、宏观环境管理政策亟待加强等问题。建议应尽快明确累积性环境风险评估概念与管理要求,制订累积性环境风险评估的流程、框架与技术指南,加强基础数据库建立和实践探索,为长效的环境风险管理提供决策依据。%With the focuses of environmental risk assessment gradually evolving from assessment of single source or stressor, single exposure route and single risk receptor toward integrated assessment involving several sources or stressors, multiple exposure routes and multiple receptors in recent years, the cumulative risk assessment has become a study hot spot.Through concepts discrimination and literatures search, the development history and assessment procedure in the US, and the methods and practices of cumulative risk assessment both at home and abroad were reviewed.It was pointed out that there were several problems in conducting cumulative risk assessment in China, such as lack of assessment methods, lack of basic scientific data and urgent need of reinforcement of macro-environmental management policy and so on.It was suggests that the concept and management requirements of cumulative environmental risk assessment should be defined, the evaluation process, framework and technical guide be formulated, and the construction of foundational databases and practical explorations be reinforced as soon as possible,which can provide the decision support for the long-term effective environmental

  17. Towards personalized screening: Cumulative risk of breast cancer screening outcomes in women with and without a first-degree relative with a history of breast cancer.

    Science.gov (United States)

    Ripping, Theodora Maria; Hubbard, Rebecca A; Otten, Johannes D M; den Heeten, Gerard J; Verbeek, André L M; Broeders, Mireille J M

    2016-04-01

    Several reviews have estimated the balance of benefits and harms of mammographic screening in the general population. The balance may, however, differ between individuals with and without family history. Therefore, our aim is to assess the cumulative risk of screening outcomes; screen-detected breast cancer, interval cancer, and false-positive results, in women screenees aged 50-75 and 40-75, with and without a first-degree relative with a history of breast cancer at the start of screening. Data on screening attendance, recall and breast cancer detection were collected for each woman living in Nijmegen (The Netherlands) since 1975. We used a discrete time survival model to calculate the cumulative probability of each major screening outcome over 19 screening rounds. Women with a family history of breast cancer had a higher risk of all screening outcomes. For women screened from age 50-75, the cumulative risk of screen-detected breast cancer, interval cancer and false-positive results were 9.0, 4.4 and 11.1% for women with a family history and 6.3, 2.7 and 7.3% for women without a family history, respectively. The results for women 40-75 followed the same pattern for women screened 50-75 for cancer outcomes, but were almost doubled for false-positive results. To conclude, women with a first-degree relative with a history of breast cancer are more likely to experience benefits and harms of screening than women without a family history. To complete the balance and provide risk-based screening recommendations, the breast cancer mortality reduction and overdiagnosis should be estimated for family history subgroups.

  18. 基于累积前景理论的出行风险分析%Cumulative Prospect Theory-based Analysis of Travel Risk

    Institute of Scientific and Technical Information of China (English)

    甘佐贤; 陈红; 冯微; 邓亚娟

    2014-01-01

    Cumulative prospect theory-based travel costs ,namely cumulative perceived value (CPV ) made up of travel time cost and arrival time perceived value is proposed in the paper .First ,the pros-pect theory as well as the further developed cumulative prospect theory is introduced ,and the concept of arrival time perceived value (ATPV) is brought in to establish the contact of arrive time and per-ceived value .Second ,a simple parallel network with variable message sign (VMS) set up or not is as an ex-ample to analysis the use of cumulative prospect theory in travel option .The result shows that ,the cumula-tive perceived value based on cumulative prospect theory is good to depict the travel choice risk under different travel environment .The existence of VMS is favorable for traveler to reduce travel cost .%将出行者基于累积前景理论的出行成本---累积感知价值(CPV )看作是由路径出行时间成本和到达目的地后的到达时间感知价值共同组成,对累积前景理论(CPT )进行了介绍,同时引入到达时间感知价值(ATPV)概念建立到达时间与出行感知价值之间的联系,以一个中间节点设置可变信息情报板(VMS)的简单平行网络为例,对累积前景理论在出行决策中的运用进行了分析。结果表明,基于累积前景理论的累积感知价值建模方式较好的刻画了不同出行环境下出行选择风险,VMS的设置有利于降低出行风险。

  19. Mineralenbalans op verschillende schapenbedrijven

    NARCIS (Netherlands)

    Boer, de J.; Bodegraven, van D.

    1994-01-01

    Uit berekeningen blijkt dat naarmate de schapenhouderij intensiever wordt, ook het overschot op de mineralenbalans toeneemt. Jaarrondproduktie heeft het hoogste overschot aan mineralen, maar daarnaast ook het hoogste saldo.

  20. Windturbines op veilige afstand

    NARCIS (Netherlands)

    Riedstra, D

    2005-01-01

    Initiatieven voor windmolenparken stuiten vaak op verzet wegens horizonvervuiling en vogelsterfte. Veiligheidsrisico’s worden slechts weinig als bezwaar aangevoerd. Toch zijn windturbines niet geheel ongevaarlijk. De aanwezigheid van gevaarlijke stoffen in de nabije omgeving is wel degelijk een fact

  1. Eikenprocessierups rukt op

    NARCIS (Netherlands)

    Moraal, L.G.

    2004-01-01

    In de landelijke inventarisatie insectenplagen 2003 vallen aantastingen door perenprachtkever en dwergcicaden het meest op. Paardekastanjemineermot, eikenprocessierups en spinselmotten werden het meest waargenomen en staan dus bovenaan in de Insecten top-tien bij de landelijke inventarisatie van ins

  2. Klimplanten op geluidsschermen

    NARCIS (Netherlands)

    Hiemstra, J.A.; Hop, M.E.C.M.; Aendekerk, T.G.L.; Hoffman, M.H.A.; Langedijk, R.P.J.

    2004-01-01

    De Nederlandse bevolking ondervindt door de toenemende drukte op de rijkswegen steeds meer overlast van het verkeerslawaai. Uit onderzoek is gebleken dat bewoners overwegend de voorkeur hebben voor begroeide schermen. Door wildgroei van verschillende typen geluidsschermen werd het totaalbeeld rommel

  3. Carcinoma in the Remnant Stomach During Long-Term Follow-up After Distal Gastrectomy for Gastric Cancer: Analysis of Cumulative Incidence and Associated Risk Factors.

    Science.gov (United States)

    Hanyu, Takaaki; Wakai, Atsuhiro; Ishikawa, Takashi; Ichikawa, Hiroshi; Kameyama, Hitoshi; Wakai, Toshifumi

    2017-09-18

    The number of patients with remnant gastric cancer following resection of gastric cancer may increase. The aims of this study were to investigate the development of remnant gastric cancer after distal gastrectomy for gastric cancer and to examine its cumulative incidence, clinicopathological characteristics, and risk factors. We examined 437 patients with relapse-free survival for 5 years or more after distal gastrectomy with Billroth I reconstruction for gastric cancer performed between 1985 and 2005. A total of 17 patients suffered from remnant gastric cancer. The cumulative incidence was 3.7% at 10 years and 5.4% at 20 years. The median time until development of remnant gastric cancer was 79 months (range 30-209 months). The presence of synchronous multiple gastric cancers was a significant independent risk factor for remnant gastric cancer (hazard ratio 4.036; 95% confidence interval 1.478-11.02; P = 0.006). Of the 17 patients, the 13 whose remnant gastric cancer was detected via regular endoscopy showed better prognoses than the patients detected by other means (P gastric cancer was 5.4% at 20 years. In particular, patients who had multiple gastric cancers at initial gastrectomy were at higher risk for remnant gastric cancer. Therefore, long-term endoscopic surveillance is important.

  4. Vulkanisme en water op Mars?

    NARCIS (Netherlands)

    Van Loef, J.; Schmets, A.J.M.

    2005-01-01

    In januari 2004 werd Mars bezocht door de tweeling robotverkenners Spirit en Opportunity. Zij werden erop uitgestuurd om eindelijk het definitieve antwoord te geven op de vraag of er leven op Mars is geweest. Alles wijst er inmiddels op dat er op Mars ooit vloeibaar water stroomde. Of daarmee een

  5. Vulkanisme en water op Mars?

    NARCIS (Netherlands)

    Van Loef, J.; Schmets, A.J.M.

    2005-01-01

    In januari 2004 werd Mars bezocht door de tweeling robotverkenners Spirit en Opportunity. Zij werden erop uitgestuurd om eindelijk het definitieve antwoord te geven op de vraag of er leven op Mars is geweest. Alles wijst er inmiddels op dat er op Mars ooit vloeibaar water stroomde. Of daarmee een be

  6. Vulkanisme en water op Mars?

    NARCIS (Netherlands)

    Van Loef, J.; Schmets, A.J.M.

    2005-01-01

    In januari 2004 werd Mars bezocht door de tweeling robotverkenners Spirit en Opportunity. Zij werden erop uitgestuurd om eindelijk het definitieve antwoord te geven op de vraag of er leven op Mars is geweest. Alles wijst er inmiddels op dat er op Mars ooit vloeibaar water stroomde. Of daarmee een be

  7. Project 6: Cumulative Risk Assessment Methods and Applications: Task 6.3. Applying Genetic and Epigenetic Data to Inform Susceptibility

    Science.gov (United States)

    Susceptibility is defined by the NRC (2009) as the capacity to be affected. A person can be at greater or less risk relative to population median risk because of susceptibility factors such as life stage, sex, genetics, socioeconomic status, prior exposure to chemicals, and non-c...

  8. Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessment.

    Science.gov (United States)

    Koch, Holger M; Wittassek, Matthias; Brüning, Thomas; Angerer, Jürgen; Heudorf, Ursel

    2011-06-01

    We determined the internal exposure of 111 German primary school starters by analyzing urinary metabolites of six phthalates: butyl benzyl phthalate (BBzP), di-iso-butyl phthalate (DiBP), di-n-butyl phthalate (DnBP), di (2-ethylhexyl) phthalate (DEHP), di-iso-nonyl phthalate (DiNP) and di-iso-decylphthalate (DiDP). From the urinary metabolite levels, we calculated daily intakes and related these values to Tolerable Daily Intake (TDI) values. By introducing the concept of a relative cumulative Tolerable Daily Intake (TDI(cum)) value, we tried to account for the cumulative exposure to several of the above-mentioned phthalates. The TDI(cum) was derived as follows: the daily intake (DI) calculated from the metabolite level was divided by the TDI for each phthalate; this ratio was multiplied by 100% indicating the TDI percentage for which the DI accounted. Finally the % TDIs of the different phthalates were totalled to get the TDI(cum). A TDI(cum) above 100% is a potential cause for concern. We confirmed the ubiquitous exposure of the children to all phthalates investigated. Exposures were within range of levels previously reported for GerES, albeit slightly lower. Regarding daily intakes, two children exceeded the TDI for DnBP, whereas one child closely approached the TDI for DEHP. 24% of the children exceeded the TDI(cum) for the three most critical phthalates: DEHP, DnBP and DiBP. Furthermore, 54% of the children had total exposures that used up more than 50% the TDI(cum). Therefore, the overall exposure to a number of phthalates, and the knowledge that these phthalates (and other anti-androgens) act in a dose-additive manner, urgently warrants a cumulative risk assessment approach.

  9. A prospective study of gynecological cancer risk in relation to adiposity factors: cumulative incidence and association with plasma adipokine levels.

    Directory of Open Access Journals (Sweden)

    Meei-Maan Wu

    Full Text Available BACKGROUND: Associations of obesity and obesity-related metabolic factors (adiposity factors with uterine corpus cancer (UCC and ovarian cancer (OVC risk have been described. Still, a cause-effect relationship and the underlying mediators remain unclear, particularly for low-incidence populations. We aimed to prospectively determine whether adiposity factors could predict the development of UCC and OVC in Taiwanese women. To explore the biological mediators linking adiposity factors to cancer risk, we examined the association of two adipokines, leptin and adiponectin, with the gynecological cancers. METHODS: Totally, 11,258 women, aged 30-65, were recruited into the Community-Based Cancer Screening Program (CBCSP study during 1991-1993, and were followed for UCC and OVC cases until December 31, 2011. Cox proportional hazard models were used to estimate hazard ratios (HRs. Adiposity factors and risk covariates were assessed at recruitment. Newly-developed cancer cases were determined from data in the government's National Cancer Registry and Death Certification System. For adipokienes study, a nested case-control study was conducted within the cohort. Baseline plasma samples of 40 incident gynecological cancer cases and 240 age-menopause-matched controls were assayed for adipokines levels. FINDINGS: There were 38 and 30 incident cases of UCC and OVC, respectively, diagnosed during a median 19.9 years of follow-up. Multivariate analysis showed that alcohol intake (HR = 16.00, 95%  = 4.83-53.00, high triglyceride levels (HR = 2.58, 95% = 1.28-5.17, and years of endogenous estrogen exposure per 5-year increment (HR = 1.91, 95%  = 1.08-3.38 were associated with increased UCC risk. High body mass index (BMI ≥ 27 kg/m(2, HR = 2.90, 95%  = 1.30-6.46 was associated with increased OVC risk. Analysis further showed an independent effect of adipokines on UCC and OVC risk after adjustment of the risk covariates. CONCLUSION: We provided evidence

  10. Impact of individual and cumulative coronary risk factors on coronary flow reserve assessed by dobutamine stress echocardiography.

    Science.gov (United States)

    Ahmari, Saeed A L; Bunch, T Jared; Modesto, Karen; Stussy, Vicky; Dichak, Amy; Seward, James B; Pellikka, Patricia A; Chandrasekaran, Krishnaswamy

    2008-06-15

    Traditional cardiovascular risk factors have been shown to cause microvascular dysfunction. Most studies that have evaluated microcirculation rely on invasive measurement tools. We used dobutamine stress echocardiography, a validated method to measure coronary flow velocity (CFV) and coronary flow reserve (CFR), in a previously unstudied population without known significant coronary artery disease to determine the impact of traditional risk factors on CFR. Consecutive patients who had no evidence of regional wall motion abnormalities at rest or during dobutamine stress echocardiography were studied. Left anterior descending artery CFV was measured at baseline and at peak dobutamine stress and CFR was calculated as the ratio of peak stress CFV to baseline CFV. Fifty-nine consecutive patients (28 men) with mean age of 66.8+/-14.5 years were studied. CFR was lower in patients with diabetes mellitus (DM) compared with those without (1.7+/-0.74 vs 2.48+/-0.98, p50 mm Hg), and obesity with a wide pulse pressure. In a multivariate model, DM, obesity, and wide pulse pressure were significantly associated with variation in CFR (p<0.0008). In conclusion, CFR was abnormal in patients with DM, hypertension, and obesity. CFR impairment is exaggerated as the number of risk factors increases. Despite a negative dobutamine stress echocardiographic result, aggressive risk factor assessment and control should be implemented in patients with coronary risk factors due to an underlying abnormal CFR.

  11. Grip op virussen

    NARCIS (Netherlands)

    Vlugt, van der R.A.A.; Verbeek, M.; Roenhorst, A.; Botermans, M.; Kock, de M.J.D.; Schadewijk, van T.; Miglino, R.; Kormelink, R.; Lent, van J.W.M.

    2011-01-01

    Aan het begin van het FES-project ‘Versterking infrastructuur plantgezondheid' zijn de belangrijkste knelpunten op plantenvirologisch gebied in Nederland geïnventariseerd. Criteria hierbij waren vooral fytosanitaire status, economisch belang en de behoefte aan betrouwbare detectie- en identificatiem

  12. Koe op snoeprantsoen

    NARCIS (Netherlands)

    Andre, G.

    2009-01-01

    Iedere koe een persoonlijk maaltje krachtvoer. Dat kan met de techniek die Geert André ontwikkelde bij de Animal Sciences Group. Het systeem van precisievoeren is sinds de zomer op de markt. Koeien kunnen zo niet meer krachtvoer snoepen dan ze nodig hebben, waardoor een boer maximaal aan hun melk ka

  13. Op og ned

    DEFF Research Database (Denmark)

    2015-01-01

    Prolog Her i 2014 færdiggøres to udsmykninger af Michael Mørk. Det ene er integreret i ny bygning til Københavns Universitet, og den anden er transformationen af den eksisterende udsmykning på Regionshospital Randers. Holdes de to projekter op mod hinanden, viser der sig tre problemstillinger, der...

  14. MTHFR gene A1298C polymorphisms are associated with breast cancer risk among Chinese population: evidence based on an updated cumulative meta-analysis

    Science.gov (United States)

    Wang, Yadong; Yang, Haiyan; Duan, Guangcai

    2015-01-01

    Objectives: Published studies on the association between methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphisms and breast cancer risk among Chinese population have yielded conflicting results. The purpose of this study was to clarify the association between MTHFR gene A1298C polymorphisms and breast cancer risk among Chinese population. Methods: Systematic searches were performed through the database of Medline/PubMed, Science Direct, Elsevier, CNKI and Wanfang Medical Online. Results: Overall, a significantly increased risk of breast cancer was observed among the subjects carrying MTHFR gene A1298C AC+CC genotype (odds ratio [OR]=1.05 with 95% confidence interval [CI]: 1.01-1.10) as compared to those carrying AA genotype among total Chinese population. We did not observe any significant association between MTHFR gene A1298C polymorphisms and the risk of breast cancer under the additional genetic models of AC vs. AA, CC vs. AA and C-allele vs. A-allele (OR=1.00 with 95% CI: 0.97-1.02, OR=1.01 with 95% CI: 1.00-1.02 and OR=1.00 with 95% CI: 0.99-1.02, respectively). The cumulative meta-analysis showed similar results. In subgroup analysis, we observed subjects carrying AC+CC genotype had an increased breast cancer risk compared with those carrying AA genotype among the studies of sample size less than 1000. We did not observe any significant association between MTHFR gene A1298C polymorphisms and breast cancer risk in additional subgroup analyses. Conclusions: Our results suggest that MTHFR gene A1298C AC+CC genotype may be a risk factor for the development of breast cancer among Chinese population. Well-designed studies with a large sample size are needed to further confirm our findings. PMID:26884927

  15. Cumulative Environmental Risk in Substance Abusing Women: Early Intervention, Parenting Stress, Child Abuse Potential and Child Development.

    Science.gov (United States)

    Kelley, Susan J.

    2003-01-01

    A study of 161 substance-abusing mothers assessed 10 maternal risk factors: maternal depression; domestic violence; nondomestic violence; family size; incarceration; no significant other at home; negative life events; psychiatric problems; homelessness; and drug use severity. Parenting stress and child abuse potential was higher for women with…

  16. Quantifying Chronic Stress Exposure for Cumulative Risk Assessment: Lessons Learned from a Case Study of Allostatic Load

    Science.gov (United States)

    Although multiple methods of quantifying environmental chemical exposures have been validated for use in human health risk assessment, quantifying chronic stress exposure is more challenging. Stress is a consequence of perceiving an “exposure” (e.g., violence, poverty) as more th...

  17. Cumulative Risk, the Mother-Child Relationship, and Social-Emotional Competence in Latino Head Start Children

    Science.gov (United States)

    Martí, Maria; Bonillo, Albert; Jané, Maria Claustre; Fisher, Elisa M.; Duch, Helena

    2016-01-01

    Research Findings: Supportive mother-child interactions promote the development of social-emotional competence. Poverty and other associated psychosocial risk factors have a negative impact on mother-child interaction. In spite of Latino children being disproportionately represented among children living in poverty, research on mother-child…

  18. Cumulative health risk assessment of halogenated and parent polycyclic aromatic hydrocarbons associated with particulate matters in urban air.

    Science.gov (United States)

    Sun, Jian-Lin; Jing, Xin; Chang, Wen-Jing; Chen, Zheng-Xia; Zeng, Hui

    2015-03-01

    Halogenated polycyclic aromatic hydrocarbons (HPAHs) have been reported to occur widely in urban air. Nevertheless, knowledge about the human health risk associated with inhalation exposure to HPAHs is scarce so far. In the present study, nine HPAHs and 16 PAHs were determined in atmospheric particulate matter (PM) collected from Shenzhen, China to address this issue. Concentrations of Σ9HPAHs varied from 0.1 to 1.5 ng/m(3) and from 0.09 to 0.4 ng/m(3) in PM10 and PM2.5 samples, respectively. As for individuals, 9-bromoanthracene, 7-bromobenz(a)anthracene, and 9,10-dibromoanthracene were the dominant congeners. Levels of Σ16PAHs in PM10 and PM2.5 samples ranged from 3.2 to 81 ng/m(3) and from 2.8 to 85 ng/m(3), respectively. Among individual PAHs, chrysene, benzo[b]fluoranthene, and indeno[1,2,3-c,d]pyrene were the main congeners. According to the season, concentrations of HPAHs and PAHs in atmospheric PM10/PM2.5 samples show a similar decreasing trend with an order: winter>autumn>spring>summer. The daily intake (DI) of PM10/PM2.5-bound HPAHs and PAHs were estimated. Our results indicated that children have the highest DI levels via inhalation exposure. The incremental lifetime cancer risk (ILCR) induced by PM10/PM2.5-bound HPAHs and PAHs were calculated. The ILCR values showed a similar decreasing trend with an order: adults>children>seniors>adolescent. Overall, the ILCR values induced by HPAHs and PAHs were far below the priority risk level (10(-4)), indicating no obvious cancer risk. To our knowledge, this is the first study to investigate the human health risk associated with inhalation exposure to PM10/PM2.5-bound HPAHs.

  19. The Soft Cumulative Constraint

    CERN Document Server

    Petit, Thierry

    2009-01-01

    This research report presents an extension of Cumulative of Choco constraint solver, which is useful to encode over-constrained cumulative problems. This new global constraint uses sweep and task interval violation-based algorithms.

  20. Proefbedrijf Rosmalen over op baconproductie

    NARCIS (Netherlands)

    Mandersloot, F.; Huiskes, J.; Parilo, M.

    2000-01-01

    Het varkensproefbedrijf in Rosmalen gaat zich in 2000 richten op baconproductie. In de vleesvarkensafdelingen worden vanaf nu beertjes opgelegd in plaats van borgen en op het gehele bedrijf wordt diermeelvrij voer verstrekt.

  1. Cumulative Risks of Foster Care Placement by Age 18 for U.S. Children, 2000–2011

    Science.gov (United States)

    Wildeman, Christopher; Emanuel, Natalia

    2014-01-01

    Foster care placement is among the most tragic events a child can experience because it more often than not implies that a child has experienced or is at very high risk of experiencing abuse or neglect serious enough to warrant state intervention. Yet it is unclear how many children will experience foster care placement at some point between birth and age 18. Using synthetic cohort life tables and data from the Adoption and Foster Care Analysis and Reporting System (AFCARS), we estimated how many U.S. children were placed in foster care between birth and age 18, finding support for three conclusions. First, up to 5.91% of all U.S. children were ever placed in foster care between their birth and age 18. Second, Native American (up to 15.44%) and Black (up to 11.53%) children were at far higher risk of placement. Foster care is thus quite common in the U.S., especially for historically disadvantaged racial/ethnic groups. Third, differences in foster care placement were minimal between the sexes, indicating that the high risks of foster care placement are shared almost equally by boys and girls. PMID:24671254

  2. Cumulative risks of foster care placement by age 18 for U.S. children, 2000-2011.

    Science.gov (United States)

    Wildeman, Christopher; Emanuel, Natalia

    2014-01-01

    Foster care placement is among the most tragic events a child can experience because it more often than not implies that a child has experienced or is at very high risk of experiencing abuse or neglect serious enough to warrant state intervention. Yet it is unclear how many children will experience foster care placement at some point between birth and age 18. Using synthetic cohort life tables and data from the Adoption and Foster Care Analysis and Reporting System (AFCARS), we estimated how many U.S. children were placed in foster care between birth and age 18, finding support for three conclusions. First, up to 5.91% of all U.S. children were ever placed in foster care between their birth and age 18. Second, Native American (up to 15.44%) and Black (up to 11.53%) children were at far higher risk of placement. Foster care is thus quite common in the U.S., especially for historically disadvantaged racial/ethnic groups. Third, differences in foster care placement were minimal between the sexes, indicating that the high risks of foster care placement are shared almost equally by boys and girls.

  3. Cumulative risks of foster care placement by age 18 for U.S. children, 2000-2011.

    Directory of Open Access Journals (Sweden)

    Christopher Wildeman

    Full Text Available Foster care placement is among the most tragic events a child can experience because it more often than not implies that a child has experienced or is at very high risk of experiencing abuse or neglect serious enough to warrant state intervention. Yet it is unclear how many children will experience foster care placement at some point between birth and age 18. Using synthetic cohort life tables and data from the Adoption and Foster Care Analysis and Reporting System (AFCARS, we estimated how many U.S. children were placed in foster care between birth and age 18, finding support for three conclusions. First, up to 5.91% of all U.S. children were ever placed in foster care between their birth and age 18. Second, Native American (up to 15.44% and Black (up to 11.53% children were at far higher risk of placement. Foster care is thus quite common in the U.S., especially for historically disadvantaged racial/ethnic groups. Third, differences in foster care placement were minimal between the sexes, indicating that the high risks of foster care placement are shared almost equally by boys and girls.

  4. Could Testosterone Replacement Therapy in Hypogonadal Men Ameliorate Anemia, a Cardiovascular Risk Factor? An Observational, 54-Week Cumulative Registry Study.

    Science.gov (United States)

    Zhang, Li Tao; Shin, Yu Seob; Kim, Ji Yong; Park, Jong Kwan

    2016-04-01

    In this study we investigated if testosterone undecanoate attenuates anemia and the risk of cardiovascular disease in patients with hypogonadism. A registry study consisted of 58 participants with a subnormal total testosterone level (less than 2.35 ng/ml) and at least mild symptoms of testosterone deficiency. All patients received an injection of 1,000 mg testosterone undecanoate at the initial visit, followed by injection at 6, 18, 30, 42 and 54 weeks. Serum hormones, hemoglobin, hematocrit, anemia risk factors, lipid profiles, whole blood viscosity and anthropometry were measured. Total testosterone (from mean ± SD 1.87 ± 1.09 to 5.52 ± 1.92 ng/ml, p testosterone (from 3.04 ± 2.03 to 7.23 ± 2.90 pg/ml, p testosterone undecanoate therapy. Hemoglobin and hematocrit significantly increased after testosterone undecanoate therapy by an average of 2.46 gm/dl (p testosterone undecanoate therapy (p = 0.047). A reduction in total cholesterol (from 165.89 ± 39.16 to 153.80 ± 154.27 mg/dl, p = 0.002), increased whole blood viscosity and increased hematocrit were observed until 54 weeks compared with baseline. However, whole blood viscosity and hematocrit stabilized after 18 weeks. After 54 weeks testosterone undecanoate decreased the prevalence of anemia and components of the metabolic syndrome. A longer duration of testosterone undecanoate therapy of more than 18 weeks may be effective and safe in reducing blood viscosity and improving anemia. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  5. Cumulative effects of bamboo sawdust addition on pyrolysis of sewage sludge: Biochar properties and environmental risk from metals.

    Science.gov (United States)

    Jin, Junwei; Wang, Minyan; Cao, Yucheng; Wu, Shengchun; Liang, Peng; Li, Yanan; Zhang, Jianyun; Zhang, Jin; Wong, Ming Hung; Shan, Shengdao; Christie, Peter

    2017-03-01

    A novel type of biochar was produced by mixing bamboo sawdust with sewage sludge (1:1, w/w) via a co-pyrolysis process at 400-600°C. Changes in physico-chemical properties and the intrinsic speciation of metals were investigated before and after pyrolysis. Co-pyrolysis resulted in a lower biochar yield but a higher C content in the end product compared with use of sludge alone as the raw material. FT-IR analysis indicates that phosphine derivatives containing PH bonds were formed in the co-pyrolyzed biochars. In addition, co-pyrolysis of sludge with bamboo sawdust transformed the potentially toxic metals in the sludge into more stable fractions, leading to a considerable decrease in their direct toxicity and bioavailability in the co-pyrolyzed biochar. In conclusion, the co-pyrolysis technology provides a feasible method for the safe disposal of metal-contaminated sewage sludge in an attempt to minimize the environmental risk from potentially toxic metals after land application. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study.

    Science.gov (United States)

    Zhang, Ming; Wang, Bingyuan; Liu, Yu; Sun, Xizhuo; Luo, Xinping; Wang, Chongjian; Li, Linlin; Zhang, Lu; Ren, Yongcheng; Zhao, Yang; Zhou, Junmei; Han, Chengyi; Zhao, Jingzhi; Hu, Dongsheng

    2017-03-01

    Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the association between triglyceride glucose (TyG) index and incident T2DM among normal-weight people in rural China. We included data from 5706 people with normal body mass index (BMI) (18.5-23.9 kg/m(2)) without baseline T2DM in a rural Chinese cohort followed for a median of 6.0 years. A Cox proportional-hazard model was used to assess the risk of incident T2DM by quartiles of TyG index and difference in TyG index between follow-up and baseline (TyG-D), estimating hazard ratios (HRs) and 95% confidence intervals (CIs). A generalized additive plot was used to show the nonparametric smoothed exposure-response association between risk of T2DM and TyG index as a continuous variable. TyG was calculated as ln [fasting triglyceride level (mg/dl) × fasting plasma glucose level (mg/dl)/2]. Risk of incident T2DM was increased with quartiles 2, 3 and 4 versus quartile 1 of TyG index (adjusted HR [aHR] 2.48 [95% CI 1.20-5.11], 3.77 [1.83-7.79], and 5.30 [2.21-12.71], P trend Risk of incident T2DM was increased with quartile 4 versus quartile 1 of TyG-D (aHR 3.91 [2.22-6.87]). The results were consistent when analyses were restricted to participants without baseline metabolic syndrome and impaired fasting glucose level. The generalized additive plot showed cumulative increased risk of T2DM with increasing TyG index. Risk of incident T2DM is increased with increasing TyG index among rural Chinese people, so the index might be an important indicator for identifying people at high risk of T2DM.

  7. UBIQUITOUS POLLUTANTS FROM CUMULATIVE ...

    Science.gov (United States)

    The occurrence of pharmaceuticals and personal care products (PPCPS) as environmental pollutants is a multifaceted issue whose scope continues to become better delineated since the escalation of concerted attention beginning in the 1980s. PPCPs typically occur as trace environmental pollutants (primarily in surface but also in ground waters) as a result of their widespread, continuous, combined usage in a broad range of human and veterinary therapeutic activities and practices. With respect to the risk-assessment paradigm, the growing body of published work has focused primarily on the origin and occurrence of these substances. Comparatively less is known about human and ecological exposure, and even less about the known or even potential hazards associated with exposure to these anthropogenic substances, many of which are highly bioactive. The continually growing, worldwide importance of freshwater resources underscores the need for ensuring that any aggregate or cumulative impacts on water supplies and resultant potential for human or ecological exposure be minimized. This has prompted the more recent investigations on waste treatment processes for one of the major sources of environmental disposition, namely sewage. Despite the paucity of health effects data for long-term, simultaneous exposure to multiple xenobiotics (particularly PPCPS) at low doses (a major toxicological issue that can be described by the

  8. Sibelius. Karelia Suite, Op. 11 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Sibelius. Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi" DG 447 760-2GH (72 minutes: DDD)

  9. Sibelius. Karelia Suite, Op. 11 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Sibelius. Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi" DG 447 760-2GH (72 minutes: DDD)

  10. Het verplicht bod op effecten

    NARCIS (Netherlands)

    Nieuwe Weme, M.P.

    2004-01-01

    Een effectenhouder die de controle verkrijgt in een beursvennootschap, brengt een openbaar bod uit op de overige effecten. Dat is de regel die in de meeste EU-lidstaten en veel andere landen bestaat. Nederland dient uiterlijk op 20 mei 2006 een dergelijk verplicht bod-regeling in te voeren. Dit is

  11. Betere beschikbaarheid op het spoor

    NARCIS (Netherlands)

    Zwier, E.; Kievit, M. de

    2014-01-01

    Nederland heeft een dicht en intensief gebruikt spoorwegnetwerk. Een kleine storing kan dan al genoeg zijn om het treinverkeer te ontregelen, met flinke vertragingen voor de reizigers als gevolg. Netwerkbeheerder prorail en TNO gaan samen op zoek naar innovaties en onorthodoxe ideeen die op het spoo

  12. Gevraagd: nieuwe kijk op economie

    NARCIS (Netherlands)

    van Dalen, H.P.; Koedijk, C.G.

    2012-01-01

    De crisis maakt duidelijk dat er een gat gaapt tussen de economische wereld die gedoceerd wordt op scholen en universiteiten, en de wereld waarin we leven. In een nieuw MJ-ebook presenteren Harry van Dalen en Kees Koedijk de visies van bekende economen op de uitdagingen voor economieonderwijs. De ho

  13. Het verplicht bod op effecten

    NARCIS (Netherlands)

    Nieuwe Weme, M.P.

    2004-01-01

    Een effectenhouder die de controle verkrijgt in een beursvennootschap, brengt een openbaar bod uit op de overige effecten. Dat is de regel die in de meeste EU-lidstaten en veel andere landen bestaat. Nederland dient uiterlijk op 20 mei 2006 een dergelijk verplicht bod-regeling in te voeren. Dit is

  14. Op weg met de Wmo

    NARCIS (Netherlands)

    Mirjam de Klerk; Rob Gilsing; Joost Timmermans; et al.

    2010-01-01

    Op 1 januari 2007 trad de Wmo, Wet maatschappelijke ondersteuning, in werking. De wet heeft als doel de zelfredzaamheid en participatiemogelijkheden van burgers te bevorderen en de sociale samenhang en leefbaarheid op lokaal niveau te versterken. Gemeenten kregen hierbij een regierol. Het

  15. Shostakovich: Two Fables, Op. 4. Four Songs, Op. 46 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "Shostakovich: Two Fables, Op. 4. Four Songs, Op. 46. Songs on Verses by British Poets, Op. 140. From Jewish folk poetry, Op. 79. Gothenburg Symphony Orchestra / Neeme Järvi" DG CD 439860-2GH

  16. Shostakovich: Two Fables, Op. 4. Four Songs, Op. 46 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "Shostakovich: Two Fables, Op. 4. Four Songs, Op. 46. Songs on Verses by British Poets, Op. 140. From Jewish folk poetry, Op. 79. Gothenburg Symphony Orchestra / Neeme Järvi" DG CD 439860-2GH

  17. Antwoord op Deist se kritiek

    Directory of Open Access Journals (Sweden)

    F. N. Lion-Cachet

    1985-06-01

    Full Text Available F. E. Deist (Des. 1984: 47—56 het in sy reaksie op my kritiek op ’n ABC van Bybeluitleg (Maart 1984 : 38—51 geoordeel dat ons verskille op kenteoretiese vlak lê en sy hele diskussie daarvolgens gevoer. Hy het my nie t.o.v. my kernkritiek op die ABC geantwoord nie maar “my kenteorie” (waaroor dit nie in my kritiek gegaan het nie as Platonies-realisties (Neoplatonies gebrandmerk en aan homself ’n histories-kritiese kenteorie in die tradisie van (Vico, Spengler, Collingwood en Popper toegeëien. Na ’n paar inleidende vraagtekens, wat ek weer kan bevraagteken, het hy tot die aanval oorgegaan. Aanval is mos die beste verdediging. Hy soek dan na voorbeelde van my “Platoniese kenteorie” en nooi my dan uit om op kenteoretiese vlak verder met hom die gesprek te voer.

  18. Reacties op technologische risico's

    NARCIS (Netherlands)

    van der Pligt, J.; de Boer, J.

    1988-01-01

    Reviews research areas that are relevant to the study of public reactions to technologic risks: risk perception, environmental stress, public acceptance and (local) public opposition, health risks, insecurity, and anxiety. These issues are illustrated with research on the public acceptance of nuclea

  19. Weiden kan op elk bedrijf

    NARCIS (Netherlands)

    Hogenkamp, W.

    2007-01-01

    Steeds vaker komt het voor dat koeien jaarrond op stal staan. Het project Koe en wij probeert hierin verandering te brengen. Met een goed beweidingsplan is het namelijk mogelijk om koeien buiten te laten grazen

  20. Smartphone controleert koeien op doping

    NARCIS (Netherlands)

    Versluis, K.; Ludwig, S.K.J.; Sterk, S.S.

    2015-01-01

    RIKILT Wageningen UR heeft een methode ontwikkeld voor het opsporen van verboden hormonen bij koeien. Een klein meetapparaatje kan samen met een smartphone op de boerderij bepalen of een boer zijn dieren het verboden hormoon rbST geeft.

  1. Learning AWS OpsWorks

    CERN Document Server

    Rosner, Todd

    2013-01-01

    A fast-paced, example-based guide to mastering AWS OpsWorks.This book is geared towards application developers, system administrators, DevOps, and anyone else interested in delivering applications while managing highly-scalable and automated infrastructures using push-button procedures. Some knowledge of what cloud computing is as well as some familiarity with Amazon Web Services is all you need as a precursor to reading this book.

  2. Cumulative fatigue damage models

    Science.gov (United States)

    Mcgaw, Michael A.

    1988-01-01

    The problem of calculating expected component life under fatigue loading conditions is complicated by the fact that component loading histories contain, in many cases, cyclic loads of widely varying amplitudes. In such a case a cumulative damage model is required, in addition to a fatigue damage criterion, or life relationship, in order to compute the expected fatigue life. The traditional cumulative damage model used in design is the linear damage rule. This model, while being simple to use, can yield grossly unconservative results under certain loading conditions. Research at the NASA Lewis Research Center has led to the development of a nonlinear cumulative damage model, named the double damage curve approach (DDCA), that has greatly improved predictive capability. This model, which considers the life (or loading) level dependence of damage evolution, was applied successfully to two polycrystalline materials, 316 stainless steel and Haynes 188. The cumulative fatigue behavior of the PWA 1480 single-crystal material is currently being measured to determine the applicability of the DDCA for this material.

  3. Assessment of Cumulative Trauma Disorder (CTD) Risk for 3 Different Tasks Constructing and Repairing Multi-Layer Insulation (MLI) Blankets, Preparing the Dough for a Pizza, and Operating the Becton-Dickinson FACSAria Flow Cytometer

    Science.gov (United States)

    Gentzler, Marc; Kline, Martin; Palmer, Andrew; Terrone, Mark

    2007-01-01

    The Cumulative Trauma Disorder (CTD) risks for three different tasks using McCauley-Bell and Badiru's (1993) formula based on task, personal, and organizational factors were examined. For the Multi-Layer Insulation (MLI) blanket task, the results showed that the task, personal, and organizational risks were at about the same level. The personal risk factors for this task were evaluated using a hypothetical female employee age 52. For the pizza dough task, it was shown that the organizational risk was particularly high, with task related factors also at quite dangerous levels. On the other hand, there was a very low level of personal risk factors, based on a female age 17. The flow cytometer task was assessed with three different participants, a11 of whom had quite disparate levels of personal risk, which slightly affected the overall CTD risk. This reveals how individual difference variables certainly need to be considered. The task and organizational risks for this task were rated at about the same moderate level. The overall CTD risk averaged across the three participants was .335, indicating some risk. Compruing across the tasks revealed that the pizza dough task created the greatest overall CTD risk by far (.568), with the MLI (.325) and flow cytometer task (.335) having some risk associated with them. Future research should look into different tasks for more of a comparison

  4. Grip op werkstress. Mindfulness ontstresst maatschappelijk werkers

    Directory of Open Access Journals (Sweden)

    Jen van Horen

    2014-03-01

    Full Text Available Taking control over work related stress. Mindfulness destresses social workersStress is a major social problem. Due to the increasing workload and the content of the work, social workers are at risk to develop stress (symptoms. The physical and psychological consequences of prolonged stress are serious. By living healthy, optimize working conditions and applying mindfulness, stress can be reduced. Mindfulness is an effective and useful way to reduce stress. It increases the resistance of workers against stress, improves brainfunctions and therefore has a positive effect on the performance. These effects are great, but they are still weakly methodologically substantiated. A pilot project within the youthcare though, was enthusiastically received and proves to be effective against stress symptoms. The exercises that are part of this pilot fit well with the needs of employees. For organizations mindfulnesstrainings are a time-and cost-effective way of structural stress prevention.Grip op werkstress. Mindfulness ontstresst maatschappelijk werkersStress is een omvangrijk maatschappelijk probleem. Door de toenemende werkdruk en de inhoud van het werk zijn maatschappelijk werkers een risicogroep om stress en stressklachten te ontwikkelen. De fysieke en psychische gevolgen die langdurige stress met zich meebrengt zijn ernstig. Door gezond te leven, de arbeidsomstandigheden te optimaliseren en mindfulness toe te passen kan stress terug worden gedrongen. Mindfulness is een effectieve en bruikbare manier om stress te verminderen. Het vergroot de weerbaarheid van werknemers tegen stress, het verbetert de hersenwerking en heeft daardoor een positief effect op het functioneren. Grote effecten dus, maar wel nog methodologisch zwak onderbouwd. Een pilot binnen de jeugdzorg op het gebied van mindfulness is enthousiast ontvangen en blijkt effectief tegen stressklachten. De oefeningen die onderdeel uitmaken van deze pilot sluiten goed aan bij de behoeften van

  5. Characterization of SNPs associated with prostate cancer in men of Ashkenazic descent from the set of GWAS identified SNPs: impact of cancer family history and cumulative SNP risk prediction.

    Directory of Open Access Journals (Sweden)

    Ilir Agalliu

    Full Text Available BACKGROUND: Genome-wide association studies (GWAS have identified multiple SNPs associated with prostate cancer (PrCa. Population isolates may have different sets of risk alleles for PrCa constituting unique population and individual risk profiles. METHODS: To test this hypothesis, associations between 31 GWAS SNPs of PrCa were examined among 979 PrCa cases and 1,251 controls of Ashkenazic descent using logistic regression. We also investigated risks by age at diagnosis, pathological features of PrCa, and family history of cancer. Moreover, we examined associations between cumulative number of risk alleles and PrCa and assessed the utility of risk alleles in PrCa risk prediction by comparing the area under the curve (AUC for different logistic models. RESULTS: Of the 31 genotyped SNPs, 8 were associated with PrCa at p ≤ 0.002 (corrected p-value threshold with odds ratios (ORs ranging from 1.22 to 1.42 per risk allele. Four SNPs were associated with aggressive PrCa, while three other SNPs showed potential interactions for PrCa by family history of PrCa (rs8102476; 19q13, lung cancer (rs17021918; 4q22, and breast cancer (rs10896449; 11q13. Men in the highest vs. lowest quartile of cumulative number of risk alleles had ORs of 3.70 (95% CI 2.76-4.97; 3.76 (95% CI 2.57-5.50, and 5.20 (95% CI 2.94-9.19 for overall PrCa, aggressive cancer and younger age at diagnosis, respectively. The addition of cumulative risk alleles to the model containing age at diagnosis and family history of PrCa yielded a slightly higher AUC (0.69 vs. 0.64. CONCLUSION: These data define a set of risk alleles associated with PrCa in men of Ashkenazic descent and indicate possible genetic differences for PrCa between populations of European and Ashkenazic ancestry. Use of genetic markers might provide an opportunity to identify men at highest risk for younger age of onset PrCa; however, their clinical utility in identifying men at highest risk for aggressive cancer remains

  6. Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1996-01-01

    Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi. 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  7. Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1996-01-01

    Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi. 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  8. Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population

    Science.gov (United States)

    Koyanagi, Yuriko N.; Ito, Hidemi; Oze, Isao; Hosono, Satoyo; Tanaka, Hideo; Abe, Tetsuya; Shimizu, Yasuhiro; Hasegawa, Yasuhisa

    2017-01-01

    Alcohol consumption and the aldehyde dehydrogenase 2 (ALDH2) polymorphism are associated with the risk of upper aerodigestive tract cancer, and a significant gene–environment interaction between the two has been confirmed in a Japanese population. To aid the development of a personalized prevention strategy, we developed a risk-prediction model and estimated absolute risks stratified by a combination of the ALDH2 genotype and alcohol consumption. We carried out two age-matched and sex-matched case–control studies: one (630 cases and 1260 controls) for model derivation and the second (654 cases and 654 controls) for external validation. On the basis of data from the derivation study, a prediction model was developed by fitting a conditional logistic regression model using the following predictors: age, sex, smoking, drinking, and the ALDH2 genotype. The risk model, including a combination of the ALDH2 genotype and alcohol consumption, provided high discriminatory accuracy and good calibration in both the derivation and the validation studies: C statistics were 0.82 (95% confidence interval 0.80–0.84) and 0.83 (95% confidence interval 0.81–0.85), respectively, and the calibration plots of both studies remained close to the ideal calibration line. Cumulative risks were obtained by combining odds ratios estimated from the risk model with the age-specific incidence rate and population size. For heavy drinkers with a heterozygous genotype, the cumulative risk at age 80 was above 20%. In contrast, risk in the other groups was less than 5%. In conclusion, modification of alcohol consumption according to the ALDH2 genotype will have a major impact on upper aerodigestive tract cancer prevention. These findings represent a simple and practical model for personalized cancer prevention. PMID:26862830

  9. Effecten van onderwatergeluid op walvissen : Op zoek naar aanvaardbare grenzen

    NARCIS (Netherlands)

    Lam, F.P.A.

    2012-01-01

    Walvissen ‘kijken’ onder water met hun oren, maar er zijn steeds meer geluidsbronnen op zee. Hoe komen we er achter wanneer walvissen last krijgen van het onderwatergeluid dat door de mens wordt gemaakt? Een van deze geluidsbronnen is sonar van de marine voor het opsporen van onderzeeboten. TNO onde

  10. Dietary glycemic index, glycemic load, and digestible carbohydrate intake are not associated with risk op type 2 diabetes in eight European countries

    NARCIS (Netherlands)

    Sluijs, van der I.; Beulens, J.W.J.; Schouw, van der Y.T.; Buckland, G.; Kuijsten, A.; Schulze, M.B.; Amiano, P.; Ardanaz, E.; Balkau, B.; Boeing, H.; Gavrila, D.; Feskens, E.J.M.

    2013-01-01

    The association of glycemic index (GI) and glycemic load (GL) with the risk of type 2 diabetes remains unclear. We investigated associations of dietary GI, GL, and digestible carbohydrate with incident type 2 diabetes. We performed a case-cohort study nested within the European Prospective Investiga

  11. Dietary glycemic index, glycemic load, and digestible carbohydrate intake are not associated with risk op type 2 diabetes in eight European countries

    NARCIS (Netherlands)

    Sluijs, van der I.; Beulens, J.W.J.; Schouw, van der Y.T.; Buckland, G.; Kuijsten, A.; Schulze, M.B.; Amiano, P.; Ardanaz, E.; Balkau, B.; Boeing, H.; Gavrila, D.; Feskens, E.J.M.

    2013-01-01

    The association of glycemic index (GI) and glycemic load (GL) with the risk of type 2 diabetes remains unclear. We investigated associations of dietary GI, GL, and digestible carbohydrate with incident type 2 diabetes. We performed a case-cohort study nested within the European Prospective

  12. Cumulative Timers for Microprocessors

    Science.gov (United States)

    Battle, John O.

    2007-01-01

    It has been proposed to equip future microprocessors with electronic cumulative timers, for essentially the same reasons for which land vehicles are equipped with odometers (total-distance-traveled meters) and aircraft are equipped with Hobbs meters (total-engine-operating time meters). Heretofore, there has been no way to determine the amount of use to which a microprocessor (or a product containing a microprocessor) has been subjected. The proposed timers would count all microprocessor clock cycles and could only be read by means of microprocessor instructions but, like odometers and Hobbs meters, could never be reset to zero without physically damaging the chip.

  13. Cumulative Vehicle Routing Problems

    OpenAIRE

    Kara, &#;mdat; Kara, Bahar Yeti&#;; Yeti&#;, M. Kadri

    2008-01-01

    This paper proposes a new objective function and corresponding formulations for the vehicle routing problem. The new cost function defined as the product of the distance of the arc and the flow on that arc. We call a vehicle routing problem with this new objective function as the Cumulative Vehicle Routing Problem (CumVRP). Integer programming formulations with O(n2) binary variables and O(n2) constraints are developed for both collection and delivery cases. We show that the CumVRP is a gener...

  14. Ongekende varkenshouderij floteert op Corsica

    NARCIS (Netherlands)

    Commandeur, M.A.M.

    2009-01-01

    De intensivering van de varkenshouderij in Europa in de tweede helft van de vorige eeuw betekende een krachtige trendbreuk met de huishoudelijke varkenshouderij van daarvoor. In heel Europa? Neen. Op Corsica ontstond er weliswaar een ontwikkeling naar gespecialiseerde bedrijven, maar die markante tr

  15. Netflix straks mee op vakantie

    NARCIS (Netherlands)

    Visser, D.J.G.

    2016-01-01

    Binnenkort kan een Nederlander met een Netflix abonnement ook op de camping in Frankrijk legaal naar zijn favoriete films en series kijken, met Nederlandse ondertiteling. Dat gebeurt wanneer de ‘Verordening betreffende de grensoverschrijdende portabiliteit van online-inhoudsdiensten in de interne ma

  16. Netflix straks mee op vakantie

    NARCIS (Netherlands)

    Visser, D.J.G.

    2016-01-01

    Binnenkort kan een Nederlander met een Netflix abonnement ook op de camping in Frankrijk legaal naar zijn favoriete films en series kijken, met Nederlandse ondertiteling. Dat gebeurt wanneer de ‘Verordening betreffende de grensoverschrijdende portabiliteit van online-inhoudsdiensten in de interne

  17. Bodemverbeteraars met focus op biochar

    NARCIS (Netherlands)

    Reuler, van H.; Baltissen, A.H.M.C.

    2016-01-01

    Biochar is een stabiele organische verbinding die hoofdzakelijk uit koolstof bestaat. Het ontstaat bij verhitting van biomassa onder zuurstofloze omstandigheden, z.g. pyrolyse. Biochar wordt geproduceerd als bodemverbeteraar. De discussie gaat om het effect van Biochar toediening op een aantal

  18. Bodemverbeteraars met focus op biochar

    NARCIS (Netherlands)

    Reuler, van H.; Baltissen, A.H.M.C.

    2016-01-01

    Biochar is een stabiele organische verbinding die hoofdzakelijk uit koolstof bestaat. Het ontstaat bij verhitting van biomassa onder zuurstofloze omstandigheden, z.g. pyrolyse. Biochar wordt geproduceerd als bodemverbeteraar. De discussie gaat om het effect van Biochar toediening op een aantal bodem

  19. Bemiddeling op de Nederlandse vrijwilligersmarkt

    Directory of Open Access Journals (Sweden)

    Els van Gilst

    2011-05-01

    Full Text Available Volunteer brokerage in the Netherlands The Dutch volunteer market can be characterized as tight. Many volunteer-involving organizations, particularly in the healthcare sector, face a shortage of volunteers. Brokerage is one (of many option(s to find new volunteers. This article describes, based on a literature review, what brokerage means, by whom or where it is offered and the importance it has as a recruitment channel. The authors explicitly address proven success factors for brokerage and the potential impact of brokerage on the preservation of volunteers. Bemiddeling op de Nederlandse vrijwilligersmarkt De Nederlandse vrijwilligersmarkt kan worden getypeerd als krap. Veel vrijwilligersorganisaties, met name in de zorgsector, kampen met een tekort aan vrijwilligers. Bemiddeling is één (van vele optie(s om nieuwe vrijwilligers te vinden. In dit artikel wordt, op basis van een literatuurstudie, beschreven wat bemiddeling inhoudt, door wie of waar het wordt geboden en welk belang het heeft als wervingskanaal. Expliciet wordt ingegaan op aangetoonde succesfactoren voor bemiddeling en de mogelijke impact van bemiddeling op het behoud van vrijwilligers.

  20. Agrarisch ondernemers leiden leerlingen op

    NARCIS (Netherlands)

    Noorduyn, L.

    2008-01-01

    Een boer of tuinder die een neventak heeft als onderwijs-leerbedrijf? In de toekomst is dat heel goed mogelijk, denkt Jan Pieter Janssen, voorzitter van het college van bestuur van het Citaverde College in Limburg. Het zou het ultieme vervolg zijn op de pilot “Bedrijf als schakelplaats in de groene

  1. Lammeren grazen op een veldkavel

    NARCIS (Netherlands)

    Eekeren, van N.J.M.

    2010-01-01

    Veel geitenbedrijven hebben een beperkt huiskavel. Als de lammeren ook op het huiskavel geweid worden, wordt de beweidingruimte voor de melkgevende geiten nog krapper. Een oplossing zou zijn om de lammeren van huis te laten grazen. Sander Koster van Gerbrande State heeft al jarenlang goede ervaringe

  2. Invloed van sport op speeksel

    NARCIS (Netherlands)

    G.J.H. Bruins; A. Vissink; E.C.I. Veerman; A. van Nieuw Amerongen

    2008-01-01

    Fysieke belasting zoals sportbeoefening kan van invloed zijn op de secretie en de samenstelling van speeksel. Bij intensieve lichamelijke inspanning daalt de concentratie van immunoglobulinen in speeksel, nemen de eiwitconcentratie - de output aan eiwitten (mg/min) blijft echter gelijk - en de visco

  3. Aandacht voor ziekten op bedrijf

    NARCIS (Netherlands)

    Bergevoet, R.H.M.

    2010-01-01

    Bedrijfsgebonden ziekten treffen niet louter de sector, maar spelen ook een rol bij antibioticaresistentie, dierenwelzijn en volksgezondheid door zoönosen. Om tot een aanpak te komen stelde Wageningen UR Livestock Research met hulp van stakeholders een lijst op van ziekten die aandacht behoeven.

  4. O&P (Ova and Parasite) Test

    Science.gov (United States)

    ... Was this page helpful? Also known as: O&P Formal name: Parasitic Examination, stool Related tests: Gastrointestinal ... is it used? The ova and parasite (O&P) exam is used to detect the presence of ...

  5. Veterinaire risico's van ongedierte op biologische varkensbedrijven

    NARCIS (Netherlands)

    Meerburg, B.G.; Kijlstra, A.

    2005-01-01

    Presentatie van de eerste resultaten van een onderzoek door Animal Sciences Group van Wageningen UR naar de ziekterisico's bij ratten en muizen. Hiervoor zijn ratten en muizen op 10 biologische varkensbedrijven met vallen gevangen en op ziektes onderzocht.

  6. Voerbeperking op jonge leeftijd bij slachtkuikens

    NARCIS (Netherlands)

    Meijerhof, R.

    1990-01-01

    Uit onderzoek in het buitenland is gebleken dat voerbeperking op jonge leeftijd bij slachtkuikens onder andere leidt tot een verminderde vetaanzet. Eerste resultaten van het proefbedrijf in Maarheeze wijzen op een duidelijke achterstand in groei.

  7. Cumulative environmental effects. Summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    This report presents a compilation of knowledge about the state of the environment and human activity in the Norwegian part of the North Sea and Skagerrak. The report gives an overview of pressures and impacts on the environment from normal activity and in the event of accidents. This is used to assess the cumulative environmental effects, which factors have most impact and where the impacts are greatest, and to indicate which problems are expected to be most serious in the future. The report is intended to provide relevant information that can be used in the management of the marine area in the future. It also provides input for the identification of environmental targets and management measures for the North Sea and Skagerrak.(Author)

  8. Project 6: Cumulative Risk Assessment Methods and ApplicationsTask 6.3: Applying Genetic and Epigenetic Data to Inform Susceptibility

    Science.gov (United States)

    Susceptibility is defined as the capacity to be affected; an individual can be at greater or less risk relative to population median risk because of susceptibility factors such as life stage, sex, genetics, socioeconomic status, prior exposure to chemicals, and non-chemical stres...

  9. Service Provider DevOps

    OpenAIRE

    John, Wolfgang; Marchetto, Guido; Németh, Felicián; Sköldström, Pontus; Steinert, Rebecca; Meirosu, Catalin; Papafili, Ioanna; Pentikousis, Kostas

    2017-01-01

    Although there is consensus that software defined networking and network functions virtualization overhaul service provisioning and deployment, the community still lacks a definite answer on how carrier-grade operations praxis needs to evolve. This article presents what lies beyond the first evolutionary steps in network management, identifies the challenges in service verification, observability, and troubleshooting, and explains how to address them using our Service Provider DevOps (SP-DevO...

  10. Tools and Techniques - Statistical. Estimating cumulative incidences in the presence of right-censoring and competing risks : an introduction with illustrations from the COACH study

    NARCIS (Netherlands)

    Postmus, Douwe; Demissei, Biniyam G; Hillege, Hans L

    2016-01-01

    In cardiovascular studies, it is common to assess the association between the risk of experiencing an event, such as death or hospitalisation, and one or more exposure variables, such as different treatment regimens when the study under consideration is an intervention study. A frequently applied

  11. Re: Could Testosterone Replacement Therapy in Hypogonadal Men Ameliorate Anemia, a Cardiovascular Risk Factor? An Observational, 54-week Cumulative Registry Study

    Directory of Open Access Journals (Sweden)

    Emre Bakırcıoğlu

    2016-09-01

    Full Text Available Testosterone deficiency syndrome may associate with erectile dysfunction, increased abdominal fat and reduced muscle mass. Low serum testosterone is also related with anemia, metabolic syndrome and cardiovascular disease. In this study, the authors investigated if testosterone undecanoate (TU reduces anemia and the risk of cardiovascular disease in patients with hypogonadism A total of 58 participants with a total testosterone level of less than 2.35 ng/ml received an injection of 1.000 mg TU 6 times; at initial visit, 6, 18, 30, 42 and 54 weeks. They observed that total testosterone and free testosterone levels were restored by TU. Hemoglobin and hematocrit levels significantly increased while anemia and total cholesterol levels significantly reduced. Although there are some limitations of this study e.g. it is not a randomized controlled and a long-term study, TU treatment in hypogonadal men decreased the prevalence of anemia, improved lipid profiles and lowered the risk of cardiovascular disease.

  12. Cumulative Alendronate Dose and the Long-Term Absolute Risk of Subtrochanteric and Diaphyseal Femur Fractures: A Register-Based National Cohort Analysis

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Eiken, Pia Agnete; Eastell, Richard

    2010-01-01

    are currently the subject of a U.S. Food and Drug Administration review. Objective: Our objective was to examine the risk of subtrochanteric/diaphyseal femur fractures in long term users of alendronate. Design: We conducted an age- and gender-matched cohort study using national healthcare data. Patients...... fractures occurred at a rate of 13 per 10,000 patient-years in untreated women and 31 per 10,000 patient-years in women receiving alendronate [adjusted hazard ratio (HR) = 1.88; 95% confidence interval (CI) = 1.62-2.17]. Rates for men were six and 31 per 10,000 patient-years, respectively (HR = 3.98; 95% CI...

  13. Voorkomen van Clostridium botulinum op melkveebedrijven

    NARCIS (Netherlands)

    Notermans SHW; Havelaar AH; Dufrenne JB; Oosterom J

    1984-01-01

    Op melkveebedrijven wordt C.botulinum regelmatig aangetroffen. De aantallen C.botulinum type B, aanwezig in monsters grond afkomstig van weilanden, varieren van 10-300 kiemen per 100 gram grond. Op bedrijven, die regelmatig weilanden met zuiveringsslib bemesten, blijkt de besmetting met C.botuli

  14. Meer groen op het schoolplein: een interventiestudie

    NARCIS (Netherlands)

    Vries, de S.; Langers, F.; Donders, J.L.M.; Willeboer, M.T.; Berg, van den A.E.

    2013-01-01

    Op vier basisscholen, gelegen in Rotterdamse aandachtswijken, is het effect van het groen herinrichten van het schoolplein op de kinderen onderzocht. Een vijfde school fungeerde als controleschool. Het onderzoek bestond uit een voormeting en twee nametingen, waarvan de eerste direct na de herinricht

  15. Is Apartheid ook op ekonomiese grond geregverdig?

    Directory of Open Access Journals (Sweden)

    B. van Deventer

    1956-03-01

    Full Text Available Die mening word vandag dikwels uitgespreek (ook deur Nasionaliste dat apartheid nie op ekonomiese gronde geregverdig kan word nie; of anders gestel, dat apartheid van die blankes te groot offers sal verg; of nog sterker gestel, dat die blankes op ekonomiese gebied nie sonder die naturel sal kan klaarkom nie.

  16. OPS83: Style Guide for High Performance.

    Science.gov (United States)

    1987-06-01

    er and ,de,,l U by Sc Mor,o’ - FIEL GRUP SB-GOUP Artificial intelligence, rule-based systems, OPS83, Rete algorithm, program optimization 19 ABTAC Coot...OPS83....................................................... I Rete Match Algorithm ....................................................... Function ...implementation of the Rete algorithm reported here. RETE MATCH ALGORITHM Function /Overview The function of the Rete match algorithm is to compute the

  17. Met uitloop meer kans op parasitaire infecties

    NARCIS (Netherlands)

    Eijck, I.A.J.M.

    2003-01-01

    Parasitaire infecties vormen een belangrijk probleem in de biologische- en scharrelhouderij. In een veldinventarisatie van het Praktijkonderzoek van ASG werden meer Ascaris suum (spoelwormen), coccidiën en Toxoplasma gondii gevonden op bedrijven met uitloop dan op bedrijven zonder uitloop. Nader ond

  18. Op-power in diabetic retinopathy

    NARCIS (Netherlands)

    K. van der Torren (Kors)

    1990-01-01

    textabstractThe present study is mainly concerned with the role of the OPs in diagnosing early diabetic retinopathy. In 1966 Simonsen had already found a clear relation between background diabetic retinopathy and the disappearance of OPs at the ascending limb of the b-wave of the ERG. Many investiga

  19. Open Access op de kaart gezet

    NARCIS (Netherlands)

    den Hollander, Franciscus

    2010-01-01

    Open Access, de vrije toegang tot wetenschappelijke informatie, wint terrein: informatie is in toenemende mate openbaar toegankelijk. Het Open Accessjaar 2009 werd op 2 februari van dit jaar afgesloten met een drukbezocht symposium in de Beurs van Berlage in Amsterdam. Dat Open Access nu echt op de

  20. Open Access op de kaart gezet

    NARCIS (Netherlands)

    den Hollander, Franciscus

    Open Access, de vrije toegang tot wetenschappelijke informatie, wint terrein: informatie is in toenemende mate openbaar toegankelijk. Het Open Accessjaar 2009 werd op 2 februari van dit jaar afgesloten met een drukbezocht symposium in de Beurs van Berlage in Amsterdam. Dat Open Access nu echt op de

  1. Op weg met de Wmo - Samenvatting

    NARCIS (Netherlands)

    Mirjam de Klerk; Rob Gilsing; Joost Timmermans; Samenvatting door Karolien Bais

    2010-01-01

    Op 1 januari 2007 trad de Wmo, Wet maatschappelijke ondersteuning, in werking. De wet heeft als doel de zelfredzaamheid en participatiemogelijkheden van burgers te bevorderen en de sociale samenhang en leefbaarheid op lokaal niveau te versterken. Gemeenten kregen hierbij een regierol. Het

  2. Factors predicting trust between GPs and OPs

    NARCIS (Netherlands)

    A.P. Nauta; J. von Grumbkow (Jasper)

    2001-01-01

    textabstractPURPOSE: To study possible differences in trust between general practitioners (GPs) and occupational physicians (OPs) and the explanatory factors for trust. Insight into the factors predicting trust can improve programmes for stimulating the co-operation of GPs and OPs.

  3. Mossen en kortsmossen op dood beukenhout

    NARCIS (Netherlands)

    Dort, van K.W.; Hees, van A.F.M.

    2003-01-01

    Tweede artikel in een serie van drie over de rol van dood beukenhout voor de biodiversiteit. In Nederlandse beukenbossen op zowel zand- als kleigrond zijn dode beukenstammen geïnventariseerd op het voorkomen van mossen (bladmossen; levermossen) en korstmossen. De soortenrijkdom per stam is sterk afh

  4. Glazunov: From the middle ages, Op.79 / Nancy Malitz

    Index Scriptorium Estoniae

    Malitz, Nancy

    1990-01-01

    Uuest heliplaadist "Glazunov: From the middle ages, Op.79, Scenes de ballet, Op.52; Liadov: A musical snuffbox, Op.31. Scottish National Orchestra, Neeme Järvi. Chandos CD cassette ABTD 1432; CD CHAN 8804"

  5. Barber. Symphony N 1, Op. 9 / Michael Oliver

    Index Scriptorium Estoniae

    Oliver, Michael

    1991-01-01

    Uuest heliplaadist "Barber. Symphony N 1, Op. 9. The School for Scandal Overture, Op. 5 Beach. Symphony in E minor, Op. 32, "Gaelic". Detroit Symphony Orchestra /Neeme Järvi" Chandes cassette ABTD 1550; CD CHAN 8958 (72 minutes)

  6. Barber. Symphony N 1, Op. 9 / Michael Oliver

    Index Scriptorium Estoniae

    Oliver, Michael

    1991-01-01

    Uuest heliplaadist "Barber. Symphony N 1, Op. 9. The School for Scandal Overture, Op. 5 Beach. Symphony in E minor, Op. 32, "Gaelic". Detroit Symphony Orchestra /Neeme Järvi" Chandes cassette ABTD 1550; CD CHAN 8958 (72 minutes)

  7. Schostakowitsch: Sinfonie N15, Op. 141 / Hanspeter Krellmann

    Index Scriptorium Estoniae

    Krellmann, Hanspeter

    1990-01-01

    Uuest heliplaadist "Schostakowitsch: Sinfonie N15, Op. 141, Oktober, Op. 131, Ouvertüre über russische und kirgisische Volksthemen, Op. 115. Göteborger Sinfonie-Orchester, Neeme Järvi". DG CD 427 616-2

  8. Glazunov: From the middle ages, Op.79 / Nancy Malitz

    Index Scriptorium Estoniae

    Malitz, Nancy

    1990-01-01

    Uuest heliplaadist "Glazunov: From the middle ages, Op.79, Scenes de ballet, Op.52; Liadov: A musical snuffbox, Op.31. Scottish National Orchestra, Neeme Järvi. Chandos CD cassette ABTD 1432; CD CHAN 8804"

  9. Candidate OP Phyla: Importance, Ecology and Cultivation Prospects.

    Science.gov (United States)

    Rohini Kumar, M; Saravanan, V S

    2010-10-01

    OP phyla were created in the domain bacteria, based on the group of 16S rRNA gene sequences recovered from the Obsidian Pool. However, due to the lack of cultured representative it is referred to as candidate phyla. Wider ecological occurrence was predicted for the OP phyla, especially OP3, OP10 and OP11. Recently, members of phylum OP5 and OP10 were cultured, providing clues to their cultivation prospects. At last the bioprospecting potentials of the OP members are discussed herein.

  10. Reuse of experience in HazOp

    OpenAIRE

    Abrahamsen, Kristin Marheim; Knudsen, Andreas

    2004-01-01

    This report presents a study of the effect of reusing experience in the Hazards and Operability Analysis method (HazOp method) with regards to how the effectiveness of the method is affected. The study was conducted by first creating a software tool for experience reuse in HazOp, then testing that tool in a student experiment in which the participants used the tool when conducting a HazOp.During the experiment it was found that students using the tool found 21% more hazards in the system unde...

  11. Childhood Cumulative Risk and Later Allostatic Load

    DEFF Research Database (Denmark)

    Doan, Stacey N; Dich, Nadya; Evans, Gary W

    2014-01-01

    Objective: The present study investigated the long-term impact of exposure to poverty-related stressors during childhood on allostatic load, an index of physiological dysregulation, and the potential mediating role of substance use. Method: Participants (n = 162) were rural children from New York...... in health across the life span and of the mechanisms by which adverse childhood environments impact health as children emerge into early adulthood. This knowledge will have implications for early intervention efforts. (PsycINFO Database Record (c) 2013 APA, all rights reserved)....

  12. 地方政府过度举债、风险累积和治理对策%Excessive Issuance, Cumulative Risks and Governance Strategies of Local Government Debt

    Institute of Scientific and Technical Information of China (English)

    方先明; 张谊浩; 蒋或

    2012-01-01

    Recently, China' s local government has been emerging the phenomenon of excessive issuance of local bonds, showing the characteristics of increasingly complicated forms, largescale expansion, significant growth of balance and relatively unbal anced structure. Factors leading to excessive issuance of local bonds include non supporting after tax system reform, appointment and examination system of local officials, inadequate decision making mechanism, not enough law constraints, and so on. Excessive issuance of local bonds, especially the rapid expansion of financing platform of local government, will lead to a variety of risks, and then slow down the development of local economy. This paper discusses about the scientific and operational governance strategies against the excessive issuance of local bonds and its corresponding cumulative risks.%当前我国地方政府出现了过度举债现象,表现出债务形式日趋复杂,规模大幅扩张,余额增速明显,结构相对失衡的特征。地方政府过度举债的原因在于分税制改革后的不配套、地方干部任命与考核制度、决策机制不完善、法制约束力不够等。地方政府过度举债特别是各级地方政府融资平台的迅速扩张势必诱发各种风险,进而阻碍地方经济发展。为此,文章针对地方政府过度举债及其风险累积,提出兼具科学性及可操作性的治理对策。

  13. De poliomyelitis epidemie op Curacao in 1981

    NARCIS (Netherlands)

    Begeer, Jacobus Hermanus

    1986-01-01

    In deze studie wordt de poliomyelitis-epidemie beschreven die zich in de eerste helft van 1981 heeft voorgedaan op het eiland Curaeao en wordt onderzoek beschreven, dat naar aanleiding van deze epidemie werd verricht. ... Zie: Samenvatting

  14. Universe of particles; expositie op CERN

    NARCIS (Netherlands)

    van Woerden, M.

    2013-01-01

    Op CERN is sinds drie jaar de tentoonstelling Universe of Particles te zien. Bezoekers kunnen hier kennismaken met CERN en meer te weten komen over wat er zich allemaal onder en boven de grond afspeelt.

  15. Op zoek naar het klimaatneutrale landschap

    NARCIS (Netherlands)

    Meerburg, B.G.

    2009-01-01

    Sinds enige jaren wordt door Plant Research International op landgoed Het Lankheet bij Haaksbergen onderzoek gedaan naar de mogelijkheden van waterzuivering door riet. Een mooi project, dat mede ondersteund wordt door waterschap Rijn en IJssel

  16. Chemische onkruidbestrijding op verhardingen : zeven machines getest

    NARCIS (Netherlands)

    Kempenaar, C.

    2009-01-01

    Met onkruidstrijkers, sensorgestuurde technieken en schijfvernevelaars mag je chemisch onkruid bestrijden op verhardingen. Maar wat is het verbruik, de selectiviteit en effectiviteit van deze technieken? Een onderzoek geeft inzicht.

  17. Korstvorming op de onderlip bij ouderen

    NARCIS (Netherlands)

    van der Waal, I.

    2014-01-01

    Op vooral de onderlip kunnen zich korstvormende afwijkingen voordoen, variërend van onschuldige herpetiforme laesies tot kwaadaardige plaveiselcelcarcinomen. In internationale classificatiesystemen wordt het slijmvlies van boven- en onderlip tot de mond gerekend en, als consequentie, vallen de herke

  18. Cumulative social disadvantage and child health.

    Science.gov (United States)

    Bauman, Laurie J; Silver, Ellen J; Stein, Ruth E K

    2006-04-01

    Disparities in child health are a major public health concern. However, it is unclear whether these are predominantly the result of low income, race, or other social risk factors that may contribute to their health disadvantage. Although others have examined the effects of the accumulation of risk factors, this methodology has not been applied to child health. We tested 4 social risk factors (poverty, minority race/ethnicity, low parental education, and not living with both biological parents) to assess whether they have cumulative effects on child health and examined whether access to health care reduced health disparities. We analyzed data on 57,553 children low parental education, and single-parent household) were consistently associated with child health. These were summed, generating the Social Disadvantage Index (range: 0-3). A total of 43.6% of children had no social disadvantages, 30.8% had 1, 15.6% had 2, and 10.0% had all 3. Compared with those with no social disadvantages, the odds ratios (ORs) of being in "good, fair, or poor health" (versus "excellent or very good") were 1.95 for 1 risk, 3.22 for 2 risks, and 4.06 for 3 risks. ORs of having a chronic condition increased from 1.25 (1 risk) to 1.60 (2 risks) to 2.11 (3 risks). ORs for activity limitation were 1.51 (1 risk) to 2.14 (2 risks) and 2.88 (3 risks). Controlling for health insurance did not affect these findings. The accumulation of social disadvantage among children was strongly associated with poorer child health and having insurance did not reduce the observed health disparities.

  19. Cumulative radiation exposure in children with cystic fibrosis.

    LENUS (Irish Health Repository)

    O'Reilly, R

    2010-02-01

    This retrospective study calculated the cumulative radiation dose for children with cystic fibrosis (CF) attending a tertiary CF centre. Information on 77 children with a mean age of 9.5 years, a follow up time of 658 person years and 1757 studies including 1485 chest radiographs, 215 abdominal radiographs and 57 computed tomography (CT) scans, of which 51 were thoracic CT scans, were analysed. The average cumulative radiation dose was 6.2 (0.04-25) mSv per CF patient. Cumulative radiation dose increased with increasing age and number of CT scans and was greater in children who presented with meconium ileus. No correlation was identified between cumulative radiation dose and either lung function or patient microbiology cultures. Radiation carries a risk of malignancy and children are particularly susceptible. Every effort must be made to avoid unnecessary radiation exposure in these patients whose life expectancy is increasing.

  20. Cumulative Trauma Among Mayas Living in Southeast Florida.

    Science.gov (United States)

    Millender, Eugenia I; Lowe, John

    2016-01-04

    Mayas, having experienced genocide, exile, and severe poverty, are at high risk for the consequences of cumulative trauma that continually resurfaces through current fear of an uncertain future. Little is known about the mental health and alcohol use status of this population. This correlational study explored t/he relationship of cumulative trauma as it relates to social determinants of health (years in the United States, education, health insurance status, marital status, and employment), psychological health (depression symptoms), and health behaviors (alcohol use) of 102 Guatemalan Mayas living in Southeast Florida. The results of this study indicated that, as specific social determinants of health and cumulative trauma increased, depression symptoms (particularly among women) and the risk for harmful alcohol use (particularly among men) increased. Identifying risk factors at an early stage before serious disease or problems are manifest provides room for early screening leading to early identification, early treatment, and better outcomes.

  1. Cumulant expansions for atmospheric flows

    CERN Document Server

    Ait-Chaalal, Farid; Meyer, Bettina; Marston, J B

    2015-01-01

    The equations governing atmospheric flows are nonlinear, and consequently the hierarchy of cumulant equations is not closed. But because atmospheric flows are inhomogeneous and anisotropic, the nonlinearity may manifests itself only weakly through interactions of mean fields with disturbances such as thermals or eddies. In such situations, truncations of the hierarchy of cumulant equations hold promise as a closure strategy. We review how truncations at second order can be used to model and elucidate the dynamics of turbulent atmospheric flows. Two examples are considered. First, we study the growth of a dry convective boundary layer, which is heated from below, leading to turbulent upward energy transport and growth of the boundary layer. We demonstrate that a quasilinear truncation of the equations of motion, in which interactions of disturbances among each other are neglected but interactions with mean fields are taken into account, can successfully capture the growth of the convective boundary layer. Seco...

  2. Electro-cumulation CNF project

    CERN Document Server

    Grishin, V G

    2000-01-01

    bound or free ion current within solid substances; non-plain symmetry; cumulation of the ion interaction. Experimental result: an Ice SuperPolarization. Cold nuclear fusion ? At http://www.shortway.to/to2084 . Keywords: ion, current, solid, symmetry, cumulation, cold nuclear fusion, polarization, depolarization, ionic conductor, superionic conductor, ice, crystal, strain, V-center, V-centre, doped crystal, interstitial impurity, intrinsic color center, high pressure technology, Bridgman, experiment, crowdion, dielectric, proton, layer, defect, lattice, dynamics, electromigration, mobility, muon catalysis, concentration, doping, dopant, conductivity, pycnonuclear reaction, permittivity, dielectric constant, point defects, interstitials, polarizability, imperfection, defect centers, glass, epitaxy, sodium hydroxide, metallic substrate, crystallization, point, tip, susceptibility, ferroelectric, ordering, force, correlation, collective, shift, distortion, coalescence, crowdions, electrolysis.

  3. Cognitive orientation to daily occupational performance (CO-OP): part II--the evidence.

    Science.gov (United States)

    Polatajko, H J; Mandich, A D; Miller, L T; Macnab, J J

    2001-01-01

    CO-OP is a child-centred, cognitive based intervention, focused on enabling children to achieve their functional goals. It has been developed over the last nine years through a series of systematic studies that have specified the treatment protocol and evaluated its effect. Initially CO-OP was explored in two series of single case experimental studies. Subsequently, an informal follow-up study and a detailed analysis of the video-taped sessions of the approach were completed. Based on information from these studies, the approach was refined, key features elucidated and the protocol was specified. Next, a pilot randomized clinical trial was completed. The trial was conducted to determine how best to approach a full scale randomized clinical trial on the effectiveness of CO-OP, relative to the current therapeutic approach. Finally, a retrospective chart audit was carried out to examine the cumulative evidence on the effectiveness of CO-OP in improving the performance of children with DCD. This paper presents a detailed summary of these five studies and discusses the implications of the findings.

  4. Gedrag op elektrische en gewone fietsen vergeleken : een experiment op de openbare weg.

    NARCIS (Netherlands)

    Twisk, D.A.M. Vlakveld, W.P. & Boele, M.J.

    2014-01-01

    Om fietsen veiliger te maken is meer inzicht nodig in de factoren die de kans op een ongeval beïnvloeden. Dit onderzoek geeft inzicht in de verschillen in fietsgedrag op elektrische en gewone fietsen voor verschillende leeftijdsgroepen en in verschillende verkeersomstandigheden. Er is gekeken naar s

  5. Gedrag op elektrische en gewone fietsen vergeleken : een experiment op de openbare weg.

    NARCIS (Netherlands)

    Twisk, D.A.M. Vlakveld, W.P. & Boele, M.J.

    2014-01-01

    Om fietsen veiliger te maken is meer inzicht nodig in de factoren die de kans op een ongeval beïnvloeden. Dit onderzoek geeft inzicht in de verschillen in fietsgedrag op elektrische en gewone fietsen voor verschillende leeftijdsgroepen en in verschillende verkeersomstandigheden. Er is gekeken naar

  6. Waterberging op landbouwgronden : effecten op plant- en dierziekten, onkruiden en contaminanten

    NARCIS (Netherlands)

    Cornelissen, A.H.M.; Harmsen, J.; Kempenaar, C.; Knol, W.C.; Zweerde, van der W.

    2003-01-01

    In deze studie zijn met een quick scan deze effecten van waterberging onderzocht. Het accent ligt daarbij op het regionale watersysteem. Daarvoor is een inventarisatie uitgevoerd van bestaande kennis bij deskundigen en is de literatuur verkend. Het accent in deze studie ligt op die stoffen en organi

  7. Risk factors for osteoporosis and fragility fractures in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Carli, L; Tani, C; Spera, V; Vagelli, R; Vagnani, S; Mazzantini, M; Di Munno, O; Mosca, M

    2016-01-01

    Osteoporosis (OP) and fragility fractures (FFx) are a known comorbidity in patients with systemic lupus erythematosus (SLE). This work aimed at evaluating (1) the prevalence of OP and FFx in a cohort of SLE and (2) the risk factors associated with both OP and FFx. The following data were collected from clinical charts: age, sex, menopausal status (MP), body mass index, smoking habits, disease duration, daily dose and cumulative glucocorticoids (GCs), type of organ involvement, comorbidities and medications. Data on bone metabolism, calcium and vitamin D supplementation and treatment with bisphosphonates, teriparatide or denosumab were collected, together with bone mineral density (BMD) values (measured by dual-energy X-ray absorptiometry (DXA)) and history of FFx (occurred after the onset of SLE and unrelated to trauma). OP and reduced BMD were defined according to the WHO. 186 patients were included (women 175, men 11; mean age 46.4±13 years, mean disease duration 14.9±9 years). At their last visit, 97 patients (52.2%) had a reduced BMD and 52 (27.9%) had OP. 22 patients (11.8%), all women, had at least one FFx; six patients (27.3%) were pre-menopausal. On univariate analysis, age, cumulative dose of GC, MP, therapy with antiepileptics and chronic renal failure (CRF) were correlated with OP (p<0.03); age, total amount of GC, MP, CRF, anticoagulants (AC) and antiepileptic therapy were correlated with FFx (p<0.05). The multivariate logistic model confirmed a direct association of OP and age, MP and antiepileptic therapy (p≤0.01) and of FFx and age, chronic therapy with AC and antiepileptics (p<0.03). In conclusion, low BMD is frequently observed in SLE, and FFx are observed also in premenopausal patients. Together with traditional risk factors (age, MP and GC), CRF and chronic treatments with AC or antiepileptics seem to be associated with a higher risk profile for OP and FFx occurrence.

  8. Cumulative Paired φ-Entropy

    Directory of Open Access Journals (Sweden)

    Ingo Klein

    2016-07-01

    Full Text Available A new kind of entropy will be introduced which generalizes both the differential entropy and the cumulative (residual entropy. The generalization is twofold. First, we simultaneously define the entropy for cumulative distribution functions (cdfs and survivor functions (sfs, instead of defining it separately for densities, cdfs, or sfs. Secondly, we consider a general “entropy generating function” φ, the same way Burbea et al. (IEEE Trans. Inf. Theory 1982, 28, 489–495 and Liese et al. (Convex Statistical Distances; Teubner-Verlag, 1987 did in the context of φ-divergences. Combining the ideas of φ-entropy and cumulative entropy leads to the new “cumulative paired φ-entropy” ( C P E φ . This new entropy has already been discussed in at least four scientific disciplines, be it with certain modifications or simplifications. In the fuzzy set theory, for example, cumulative paired φ-entropies were defined for membership functions, whereas in uncertainty and reliability theories some variations of C P E φ were recently considered as measures of information. With a single exception, the discussions in the scientific disciplines appear to be held independently of each other. We consider C P E φ for continuous cdfs and show that C P E φ is rather a measure of dispersion than a measure of information. In the first place, this will be demonstrated by deriving an upper bound which is determined by the standard deviation and by solving the maximum entropy problem under the restriction of a fixed variance. Next, this paper specifically shows that C P E φ satisfies the axioms of a dispersion measure. The corresponding dispersion functional can easily be estimated by an L-estimator, containing all its known asymptotic properties. C P E φ is the basis for several related concepts like mutual φ-information, φ-correlation, and φ-regression, which generalize Gini correlation and Gini regression. In addition, linear rank tests for scale that

  9. The Algebra of the Cumulative Percent Operation.

    Science.gov (United States)

    Berry, Andrew J.

    2002-01-01

    Discusses how to help students avoid some pervasive reasoning errors in solving cumulative percent problems. Discusses the meaning of ."%+b%." the additive inverse of ."%." and other useful applications. Emphasizes the operational aspect of the cumulative percent concept. (KHR)

  10. Adaptive strategies for cumulative cultural learning.

    Science.gov (United States)

    Ehn, Micael; Laland, Kevin

    2012-05-21

    The demographic and ecological success of our species is frequently attributed to our capacity for cumulative culture. However, it is not yet known how humans combine social and asocial learning to generate effective strategies for learning in a cumulative cultural context. Here we explore how cumulative culture influences the relative merits of various pure and conditional learning strategies, including pure asocial and social learning, critical social learning, conditional social learning and individual refiner strategies. We replicate the Rogers' paradox in the cumulative setting. However, our analysis suggests that strategies that resolved Rogers' paradox in a non-cumulative setting may not necessarily evolve in a cumulative setting, thus different strategies will optimize cumulative and non-cumulative cultural learning.

  11. "Buddha's Light" of Cumulative Particles

    CERN Document Server

    Kopeliovich, Vladimir B; Potashnikova, Irina K

    2014-01-01

    We show analytically that in the cumulative particles production off nuclei multiple interactions lead to a glory-like backward focusing effect. Employing the small phase space method we arrived at a characteristic angular dependence of the production cross section $d\\sigma \\sim 1/ \\sqrt {\\pi - \\theta}$ near the strictly backward direction. This effect takes place for any number $n\\geq 3 $ of interactions of rescattered particle, either elastic or inelastic (with resonance excitations in intermediate states), when the final particle is produced near corresponding kinematical boundary. Such a behaviour of the cross section near the backward direction is in qualitative agreement with some of available data.

  12. A Resource Cost Aware Cumulative

    Science.gov (United States)

    Simonis, Helmut; Hadzic, Tarik

    We motivate and introduce an extension of the well-known cumulative constraint which deals with time and volume dependent cost of resources. Our research is primarily interested in scheduling problems under time and volume variable electricity costs, but the constraint equally applies to manpower scheduling when hourly rates differ over time and/or extra personnel incur higher hourly rates. We present a number of possible lower bounds on the cost, including a min-cost flow, different LP and MIP models, as well as greedy algorithms, and provide a theoretical and experimental comparison of the different methods.

  13. Maintenance hemodialysis patients have high cumulative radiation exposure.

    LENUS (Irish Health Repository)

    Kinsella, Sinead M

    2010-10-01

    Hemodialysis is associated with an increased risk of neoplasms which may result, at least in part, from exposure to ionizing radiation associated with frequent radiographic procedures. In order to estimate the average radiation exposure of those on hemodialysis, we conducted a retrospective study of 100 patients in a university-based dialysis unit followed for a median of 3.4 years. The number and type of radiological procedures were obtained from a central radiology database, and the cumulative effective radiation dose was calculated using standardized, procedure-specific radiation levels. The median annual radiation dose was 6.9 millisieverts (mSv) per patient-year. However, 14 patients had an annual cumulative effective radiation dose over 20 mSv, the upper averaged annual limit for occupational exposure. The median total cumulative effective radiation dose per patient over the study period was 21.7 mSv, in which 13 patients had a total cumulative effective radiation dose over 75 mSv, a value reported to be associated with a 7% increased risk of cancer-related mortality. Two-thirds of the total cumulative effective radiation dose was due to CT scanning. The average radiation exposure was significantly associated with the cause of end-stage renal disease, history of ischemic heart disease, transplant waitlist status, number of in-patient hospital days over follow-up, and death during the study period. These results highlight the substantial exposure to ionizing radiation in hemodialysis patients.

  14. A prevalência cumulativa de fatores de risco para doença cardiovascular em adolescentes iranianos: IHHP-HHPC Cumulative prevalence of risk factors for atherosclerotic cardiovascular diseases in Iranian adolescents: IHHP-HHPC

    Directory of Open Access Journals (Sweden)

    Roya Kelishadi

    2005-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência cumulativa dos fatores de risco para a doença cardiovascular aterosclerótica numa amostra de adolescentes iranianos. MÉTODOS: Foi realizado um estudo transversal com 1000 meninas e 1000 meninos, com idade entre 11 e 18 anos, selecionados através de uma amostragem aleatória multietapas à base de conglomerados das áreas urbana e rural de três cidades iranianas. RESULTADOS: As taxas de prevalência de inatividade física, dislipidemia, tabagismo, pressão arterial alta e obesidade (índice de massa corporal >P95 foram 66,6, 23,7, 8,7, 5,7 e 2,2%, respectivamente. Dentre os indivíduos estudados, 79,1% apresentaram pelo menos um e 24,6% tiveram dois fatores de risco para doença cardiovascular. A prevalência de inatividade física foi significativamente menor entre os meninos que entre as meninas [53,9 contra 79,3%, respectivamente, OR IC95%, 0,44 (0,39-0,51]. A prevalência de tabagismo foi maior nos meninos que nas meninas [13,1 contra 4,2%, respectivamente, OR IC95%, 3,4 (2,4-4,9]. CONCLUSÃO: Considerando a alta prevalência de fatores de risco para doença cardiovascular em adolescentes, deve-se garantir intervenções que sejam adequadas à idade e sensíveis a aspectos culturais para que medidas preventivas possam ser tomadas em tempo hábil.OBJECTIVE: To evaluate the cumulative prevalence of atherosclerotic cardiovascular disease risk factors in a representative sample of Iranian adolescents. METHODS: The subjects of this cross-sectional study were 1,000 girls and 1,000 boys, ages 11-18 years, selected by multi stage-random cluster sampling from urban and rural areas of three cities in Iran. RESULTS: The prevalence of physical inactivity, dyslipidemia, smoking, high blood pressure and obesity (body mass index >95th percentile were 66.6, 23.7, 8.7, 5.7 and 2.2%, respectively. Of subjects studied, 79.1% had at least one and 24.6% had two cardiovascular disease risk factors. The prevalence of physical

  15. Cumulative Incidence of Cancer After Solid Organ Transplantation

    Science.gov (United States)

    Hall, Erin C.; Pfeiffer, Ruth M.; Segev, Dorry L.; Engels, Eric A.

    2014-01-01

    BACKGROUND Solid organ transplantation recipients have elevated cancer incidence. Estimates of absolute cancer risk after transplantation can inform prevention and screening. METHODS The Transplant Cancer Match Study links the US transplantation registry with 14 state/regional cancer registries. The authors used nonparametric competing risk methods to estimate the cumulative incidence of cancer after transplantation for 2 periods (1987–1999 and 2000–2008). For recipients from 2000 to 2008, the 5-year cumulative incidence, stratified by organ, sex, and age at transplantation, was estimated for 6 preventable or screen-detectable cancers. For comparison, the 5-year cumulative incidence was calculated for the same cancers in the general population at representative ages using Surveillance, Epidemiology, and End Results data. RESULTS Among 164,156 recipients, 8520 incident cancers were identified. The absolute cancer risk was slightly higher for recipients during the period from 2000 to 2008 than during the period from 1987 to 1999 (5-year cumulative incidence: 4.4% vs 4.2%; P =.006); this difference arose from the decreasing risk of competing events (5-year cumulative incidence of death, graft failure, or retransplantation: 26.6% vs 31.9%; P 50 years; range, 0.36%–2.22%). For recipients aged >50 years, the 5-year cumulative incidence was higher for colorectal cancer (range, 0.33%–1.94%) than for the general population at the recommended screening age (aged 50 years: range, 0.25%–0.33%). For recipients aged >50 years, the 5-year cumulative incidence was high for lung cancer among thoracic organ recipients (range, 1.16%–3.87%) and for kidney cancer among kidney recipients (range, 0.53%–0.84%). The 5-year cumulative incidence for prostate cancer and breast cancer was similar or lower in transplantation recipients than at the recommended ages of screening in the general population. CONCLUSIONS Subgroups of transplantation recipients have a high absolute risk

  16. Hierarchical Bayesian parameter estimation for cumulative prospect theory

    NARCIS (Netherlands)

    Nilsson, H.; Rieskamp, J.; Wagenmakers, E.-J.

    2011-01-01

    Cumulative prospect theory (CPT Tversky & Kahneman, 1992) has provided one of the most influential accounts of how people make decisions under risk. CPT is a formal model with parameters that quantify psychological processes such as loss aversion, subjective values of gains and losses, and

  17. Cumulative psychosocial stress, coping resources, and preterm birth.

    Science.gov (United States)

    McDonald, Sheila W; Kingston, Dawn; Bayrampour, Hamideh; Dolan, Siobhan M; Tough, Suzanne C

    2014-12-01

    Preterm birth constitutes a significant international public health issue, with implications for child and family well-being. High levels of psychosocial stress and negative affect before and during pregnancy are contributing factors to shortened gestation and preterm birth. We developed a cumulative psychosocial stress variable and examined its association with early delivery controlling for known preterm birth risk factors and confounding environmental variables. We further examined this association among subgroups of women with different levels of coping resources. Utilizing the All Our Babies (AOB) study, an ongoing prospective pregnancy cohort study in Alberta, Canada (n = 3,021), multinomial logistic regression was adopted to examine the independent effect of cumulative psychosocial stress and preterm birth subgroups compared to term births. Stratified analyses according to categories of perceived social support and optimism were undertaken to examine differential effects among subgroups of women. Cumulative psychosocial stress was a statistically significant risk factor for late preterm birth (OR = 1.73; 95 % CI = 1.07, 2.81), but not for early preterm birth (OR = 2.44; 95 % CI = 0.95, 6.32), controlling for income, history of preterm birth, pregnancy complications, reproductive history, and smoking in pregnancy. Stratified analyses showed that cumulative psychosocial stress was a significant risk factor for preterm birth at psychosocial stress on the risk for early delivery.

  18. A paradox of cumulative culture.

    Science.gov (United States)

    Kobayashi, Yutaka; Wakano, Joe Yuichiro; Ohtsuki, Hisashi

    2015-08-21

    Culture can grow cumulatively if socially learnt behaviors are improved by individual learning before being passed on to the next generation. Previous authors showed that this kind of learning strategy is unlikely to be evolutionarily stable in the presence of a trade-off between learning and reproduction. This is because culture is a public good that is freely exploited by any member of the population in their model (cultural social dilemma). In this paper, we investigate the effect of vertical transmission (transmission from parents to offspring), which decreases the publicness of culture, on the evolution of cumulative culture in both infinite and finite population models. In the infinite population model, we confirm that culture accumulates largely as long as transmission is purely vertical. It turns out, however, that introduction of even slight oblique transmission drastically reduces the equilibrium level of culture. Even more surprisingly, if the population size is finite, culture hardly accumulates even under purely vertical transmission. This occurs because stochastic extinction due to random genetic drift prevents a learning strategy from accumulating enough culture. Overall, our theoretical results suggest that introducing vertical transmission alone does not really help solve the cultural social dilemma problem. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Melkproductie op triticalekuil hoger dan verwacht

    NARCIS (Netherlands)

    Meijer, R.

    1997-01-01

    Op droogtegevoelige gronden zonder beregening kan de teelt van triticale een aantrekkelijk alternatief zijn voor gras of snijmais. Gehakseld en ingekuild (Gehele Plant Silage) kan met dit gewas een relatief hoge droge-stofopbrengst worden gehaald. Nadeel van triticalekuil is dat de berekende voederw

  20. Fabricating an S&OP Process

    DEFF Research Database (Denmark)

    Lichen, Alex Yu

    Inspired by Latour’s (2005a) notion of matters of concern and M.C. Escher’s Circle Limit III as a representation of the Poincaré Disk, this study follows how an S&OP process was fabricated in a large Swedish manufacturing company. The study claims that when actors are fabricating the S&OP process......, local actors create emergent, ongoing and multiple matters of concern around it. The group demand chain, the actor who is responsible for guiding the implementation of the process, delegates the attempts to close these matters of concern to local actors located in separate times and spaces. As a result......, constituents of the S&OP process are dispersed in diverse local times and spaces rather than being coordinated in a single time and space by the group demand chain. Accounting is a set of matters of concern. The S&OP process and its purpose of integration come from an “absolute nothingness” – its minimal...

  1. De jacht op het geheim van cacao

    NARCIS (Netherlands)

    Hollman, P.C.H.

    2008-01-01

    Je kans op een dodelijke hartaanval halveert als je elke dag een groot paaseitje pure chocolade eet, blijkt uit een recente Nederlandse epidemiologische studie. En ook andere studies laten zien dat consumptie van cacao beschermt tegen hart- en vaatziekten. Maar het is nog een raadsel hoe dat precies

  2. Dynamisch melken en voeren levert geld op

    NARCIS (Netherlands)

    Ouweltjes, W.; Andre, G.; Zom, R.L.G.; Bleumer, E.J.B.

    2008-01-01

    Op het High-techbedrijf van de Waiboerhoeve is in 2006 een prototype voor een dynamisch lineair adviessysteem voor melken en voeren ontwikkeld en getoetst. De resultaten geven aan dat met deze benadering een aanzienlijk beter saldo behaald kan worden dan met traditionele adviezen

  3. Varkenshouderij moet fokken op 'gezond vlees'

    NARCIS (Netherlands)

    Arendonk, van J.A.M.

    2005-01-01

    De varkenshouderij moet de gezondheid van het vlees in haar veeverbetering betrekken. Dat zei Johan van Arendonk, hoogleraar fokkerij en genetica in Wageningen op de ledenvergadering van fokkerijorganisatie Pigture Group. Hij ziet de weg daarnaartoe niet in de traditionele fokkerij. Hij ziet sneller

  4. Wie Let Er Op De Kleintjes?

    NARCIS (Netherlands)

    Menting, Ankie; Orobio De Castro, Bram

    2014-01-01

    Het onderliggende rapport betreft een verslag van het onderzoek dat door Dr. Ankie Menting en Prof. dr. Bram Orobio de Castro (Universiteit Utrecht), in opdracht van Humanitas, is uitgevoerd naar het project Wie Let Er Op De Kleintjes (WLEODK) van Gezin in Balans (Humanitas). In dit onderzoek, dat u

  5. Verwerking van zeugenmest op de boerderij

    NARCIS (Netherlands)

    Voermans, J.

    1991-01-01

    De afzet van de dunne mest op vermeerderingsbedrijven is een groeiend probleem. Het gebruik van veel drink- en schoonmaakwater zorgen er voor, dat het droge stofgehalte van de mest vaak niet boven de 5% uitkomt. In het onderzoek zijn reeds goede scheidingsresultaten behaald door deze mest te laten b

  6. Die invloed van doelwitstelling op prestasie

    Directory of Open Access Journals (Sweden)

    J. G. A. Louw

    1985-11-01

    Full Text Available Although a number of research studies support Locke's goal setting theory, conflicting results are encountered in the Literature which suggest further investigation into the subtleties of the theory. The results of this study indicate that an increase in goal-difficulty does not always lead to a corresponding increase in performance. The latter could also not be explained in terms of the degree of goal-acceptance as an intervening variable. It was found that financial incentives and the way in which a nonspecific goal is formulated could have a significant effect on performance. Recommendations are made for future research.OpsommingOfskoon die meeste navorsing Locke se doelwitstellingsteorie ondersteun, is bepaalde afwykings teengekom wat nie op 'n bevredigende wyse verklaar kan word nie. Die resultate van hierdie studie dui daarop dat 'n toename in doelwitmoeilikheidsgraad nie altyd tot ‘n ooreenstemmende toename in prestasie lei nie. Hierdie resultaat kon ook nie op grond van 'n gebrek aan doelwitaanvaarding verklaar word nie. Daar is voorts gevind dat die wyse waarop 'n nie-spesifieke doelwit gestel word, 'n beduidende invloed op prestasie kan hê. Finansiële aansporings blyk ook 'n onafhanklike invloed op prestasie te hê. Bepaalde aspekte van Locke se teorie word dus deur bogenoemde resultate bevraagteken. Aanbevelings vir verdere navorsing word ten slotte gedoen.

  7. Zwemmers op zoek naar een vast punt.

    NARCIS (Netherlands)

    Maas, L.R.M.

    2016-01-01

    Archimedes’ uitspraak “Geef mij een vast punt en ik zal de aarde bewegen” geldt ook voor zwemmers. In hun geval om, op meer bescheiden schaal, hun lichaam voort te stuwen. Tijdens mooi weer kan dat vermogen om zich tegen water af te zetten verminderen. Opwarming van oppervlaktewater leidt tot een gr

  8. Invloed spoorelementen op groei en ontwikkeling kalanchoe

    NARCIS (Netherlands)

    Verberkt, H.; Berg, van den D.

    1998-01-01

    Het doel van het onderzoek was nagaan wat de invloed van spoorelementen is op de groei en ontwikkeling van Kalanchoe. Hierbij is onderzoek gedaan naar de effecten van gebrek en overmaat van de belangrijkste zes spoorelementen: ijzer, mangaan, zink, molybdeen, koper en borium.

  9. Sociologische kijk op verantwoordelijkheid voor natuur

    NARCIS (Netherlands)

    Dagevos, H.; Breedveld, K.

    2004-01-01

    De disciplinaire invalshoek van dit essay is de sociale. In de eerste plaats wordt ingegaan op verantwoordelijkheid als moderne notie, gezien vanuit de geïndividualiseerde postmoderne samenleving. Vervolgens wordt het begrip "vertaald" in termen van bestedingen in tijd en geld. De sociale context is

  10. De jacht op het geheim van cacao

    NARCIS (Netherlands)

    Hollman, P.C.H.

    2008-01-01

    Je kans op een dodelijke hartaanval halveert als je elke dag een groot paaseitje pure chocolade eet, blijkt uit een recente Nederlandse epidemiologische studie. En ook andere studies laten zien dat consumptie van cacao beschermt tegen hart- en vaatziekten. Maar het is nog een raadsel hoe dat precies

  11. Zicht op de plantaardige biologische keten

    NARCIS (Netherlands)

    Wijnands, J.H.M.; Meeusen-van Onna, M.J.G.; Hoorweg, M.J.; Kik, C.; Rossing, W.A.H.; Scholten, O.M.

    2005-01-01

    De studie vormt een onderdeel van het project 'Visies op biologische landbouw: een systeem analyse'. Dit project is gefinancierd door Wageningen Universiteit en Researchcentrum uit middelen voor Strategische Expertise Ontwikkeling. In dit project worden mensbeelden onderscheiden om de visies te conc

  12. Energiebesparing en duurzame energie op praktijkcentrum Sterksel

    NARCIS (Netherlands)

    Wagenberg, van V.

    2003-01-01

    Energie is sinds jaar en dag een belangrijk onderzoeksthema op Praktijkcentrum Sterksel. Daarom is er een energiemonitoring-systeem aangelegd en zijn er meerdere energiezuinige stalontwerpen en installaties geonstalleerd. Verwarmen en ventileren van de stallen zal echter altijd energie blijven vrage

  13. Koersen op Scheldemondsteden: een bestuurlijke terreinverkenning

    NARCIS (Netherlands)

    W.J. Oosten

    2002-01-01

    textabstractPaper voor de PlanDag 2002 "De steden begrensd?" op 6 juni te Dordrecht. Georganiseerd door de Bond van Nederlandse Stedenbouwers en Planologen (BNSP), de Vlaamse Vereniging voor Ruimte en Planning (VRP) en de Stichting Planologische DiscussieDagen (PDD).

  14. Met apps op eigen benen leren staan

    NARCIS (Netherlands)

    Jan-Pieter Teunisse

    2012-01-01

    Mensen met autisme kunnen in de toekomst zelfstandiger wonen, werken en studeren met behulp van `digitale coaches' op hun mobieltje, iPad of iPod. Bij het testen van deze apps en andere nieuwe technologische hulpmiddelen, is ook de HAN betrokken. `ICT-oplossingen kunnen iemand helpen om meer regie

  15. Residuen op groenten en fruit ter discussie

    NARCIS (Netherlands)

    Woltering, E.J.

    2011-01-01

    De nVWA en het RIVM doen al jaren onderzoek naar residuen van giftige stoffen op groenten en fruit. Uit onderzoek blijkt dat met name peuters en baby’s meer groenten en fruit binnenkrijgen dan eerder werd gedacht. Met meer groenten en fruit zouden ze ook meer residuen binnenkrijgen. Ernst Woltering

  16. Verschillen in elektriciteitsverbruik op friese melkveebedrijven

    NARCIS (Netherlands)

    Telle, M.G.; Knies, P.

    1995-01-01

    Om als individuele melkveehouder het elektriciteits- en dieselverbruik op het bedrijf te kunnen verminderen is het noodzakelijk om inzicht te hebben in het huidige verbruik en in de besparingsmogelijkheden. Vandaar dat een energiezorgsysteem voor de melkveehouderij is ontwikkeld. In dit project is n

  17. Residuen op groenten en fruit ter discussie

    NARCIS (Netherlands)

    Woltering, E.J.

    2011-01-01

    De nVWA en het RIVM doen al jaren onderzoek naar residuen van giftige stoffen op groenten en fruit. Uit onderzoek blijkt dat met name peuters en baby’s meer groenten en fruit binnenkrijgen dan eerder werd gedacht. Met meer groenten en fruit zouden ze ook meer residuen binnenkrijgen. Ernst Woltering

  18. Privacy beleving op het internet in Nederland

    NARCIS (Netherlands)

    Roosendaal, A.P.C.; Nieuwenhuis, O.A.; Ooms, M.; Bouman-Eijs, J.M.; Huijboom, N.M.

    2015-01-01

    Dit rapport bevat de bevindingen van een survey onder een representatieve steekproef van de Nederlandse bevolking over de beleving van privacy op het internet. Deze beleving hebben we onderzocht aan de hand van een zevental factoren: persoonskenmerken, ervaringen, feitelijk gedrag, context, technolo

  19. Terugblik op psychosociale hulp na MH17.

    NARCIS (Netherlands)

    Drogendijk, A.; Dückers, M.; Holsappel, J.; Sardemann, R.; Alting, D.

    2016-01-01

    De ramp met MH17 confronteerde duizenden Nederlanders, verspreid over het hele land, met het verlies van familieleden, vrienden, collega’s, klasgenoten, buren of verenigingsleden. De maatschappelijke betrokkenheid was groot. In deze bijdrage blikken we kort terug op het totale psychosociale nazorgpr

  20. Koersen op Scheldemondsteden: een bestuurlijke terreinverkenning

    NARCIS (Netherlands)

    W.J. Oosten

    2002-01-01

    textabstractPaper voor de PlanDag 2002 "De steden begrensd?" op 6 juni te Dordrecht. Georganiseerd door de Bond van Nederlandse Stedenbouwers en Planologen (BNSP), de Vlaamse Vereniging voor Ruimte en Planning (VRP) en de Stichting Planologische DiscussieDagen (PDD).

  1. Boomkwekerij op veen : bedrijfseconomische resultaten biologische boomkwekerij

    NARCIS (Netherlands)

    Snoek, B.; Schuring, W.; Leijden, van J.P.H.

    2003-01-01

    Resultaten van een onderzoek op PPO-locatie Boskoop naar de bedrijfseconomische mogelijkheden van biologische boomteelt. Zes gewassen uit de gewasgroep siergewassen (Acer, Buxus, Magnolia, Mahonia, Prunus en Syringa) werden in twee jaar opgekweekt van plantgoed naar leverbaar materiaal. In tabellen

  2. Existence of Solutions of a Riccati Differential System from a General Cumulant Control Problem

    Directory of Open Access Journals (Sweden)

    Stanley R. Liberty

    2011-01-01

    Full Text Available We study a system of infinitely many Riccati equations that arise from a cumulant control problem, which is a generalization of regulator problems, risk-sensitive controls, minimal cost variance controls, and k-cumulant controls. We obtain estimates for the existence intervals of solutions of the system. In particular, new existence conditions are derived for solutions on the horizon of the cumulant control problem.

  3. Arensky. Silhouettes (Suite N 2), Op. 23 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Arensky. Silhouettes (Suite N 2), Op. 23. Scrjabin. Symphony N 3 in C minor, Op. 43 "Le divin poeme". Danish National Radio Symphony Orchestra. Neeme Järvi. Chandos cassette ABTD 1509; CD CHAN 8898 (66 minutes)

  4. Tchaikovsky, P.: Orchestral Suite no. 3 op. 55 / Terry Williams

    Index Scriptorium Estoniae

    Williams, Terry

    1996-01-01

    Uuest heliplaadist "Tchaikovsky, P.: Orchestral Suite no. 3 op. 55. Francesca di Rimini op. 32. Detroit Symphony Orchestra, Neeme Järvi". Chandos CHAN 9 419, distribution Media 7 (CD: 160F). TT: 1h 09'20"

  5. Arensky. Silhouettes (Suite N 2), Op. 23 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Arensky. Silhouettes (Suite N 2), Op. 23. Scrjabin. Symphony N 3 in C minor, Op. 43 "Le divin poeme". Danish National Radio Symphony Orchestra. Neeme Järvi. Chandos cassette ABTD 1509; CD CHAN 8898 (66 minutes)

  6. Defined ambition: op weg naar een houdbaar pensioencontract

    NARCIS (Netherlands)

    Tamerus, J.

    2011-01-01

    In juni promoveerde Jan Tamerus op ‘defined ambition’. In deze bijdrage legt hij in het kort uit waarom en hoe defined ambition een noodzakelijke stap vormt op de weg naar een houdbaar pensioencontract.

  7. Tchaikovsky, P.: Orchestral Suite no. 3 op. 55 / Terry Williams

    Index Scriptorium Estoniae

    Williams, Terry

    1996-01-01

    Uuest heliplaadist "Tchaikovsky, P.: Orchestral Suite no. 3 op. 55. Francesca di Rimini op. 32. Detroit Symphony Orchestra, Neeme Järvi". Chandos CHAN 9 419, distribution Media 7 (CD: 160F). TT: 1h 09'20"

  8. Drieteenmeeuw vestigt zich op meerdere platforms in Nederlandse wateren

    NARCIS (Netherlands)

    Camphuysen, C.J.; Leopold, M.F.

    2007-01-01

    In de zomer van 2000 werden op een olieplatform in het zuidelijk deel van de Noordzee Drieteenmeeuwen ontdekt. Bij een bezoek in 2005 werd zelfs een kolonie ontdekt. In 2006 werden ook op andere platforms nog Drieteenmeeuwen aangetroffen.

  9. Emissie-arme mesttoediening op klei en veen

    NARCIS (Netherlands)

    Verburg, S.; Corporaal, J.

    1993-01-01

    In dit artikel wordt ingegaan op een aantal technische aspecten van emissie-arme mesttoediening. In het Praktijkonderzoek van februari 1993 is al aandacht besteed aan het effect van emissie-arme mesttoediening op het broedsucces van weidevogels.

  10. Mineralenbehoefte : koper en selenium vragen aandacht op Bioveembedrijven

    NARCIS (Netherlands)

    Smolders, E.A.A.; Plomp, M.

    2005-01-01

    Bij het streven naar zelfvoorziening en het telen van eigen krachtvoer is op biologische bedrijven extra aandacht nodig voor de mineralen en spoorelementen. Het jongvee heeft de grootste kans op tekorten, zo blijkt uit resultaten van het project Bioveem

  11. Prokofiev: Sinfonia Concertante Op. 125 / Pierre-E. Barbier

    Index Scriptorium Estoniae

    Barbier, Pierre-E.

    1998-01-01

    Uuest heliplaadist "Prokofiev: Sinfonia Concertante Op. 125; Miaskowsky: Cello Concerto Op. 66, sellisti Truls Mörk ja City of Birmingham Symphony Orchestra, joht. Paavo Järvi" Virgin Classics 5 45282 2. (1988)

  12. Final Service Provider DevOps concept and evaluation

    OpenAIRE

    Marchetto, Guido; Sisto, Riccardo; John, Wolfgang; Sköldström, Pontus; Pechenot, Bertrand; Németh, Felicián; Pelle, István; Kim, Juhoon; Cai, Xuejun; Fu, Chunyan; Meirosu, Catalin; Pentikousis, Kostas; Sharma, Sachin; Papafili, Ioanna; Spinoso, Serena

    2016-01-01

    This report presents the results of the UNIFY Service Provider DevOps activities. First, we present the final definition and assessment of the concept. SP-DevOps is realized by a combination of various functional components facilitating integrated service verification, efficient and programmable observability, and automated troubleshooting processes. Our assessment shows that SP-DevOps can help providers to reach a medium level of DevOps maturity and allows significant reduction in OPEX. Seco...

  13. Management Challenges for DevOps Adoption within UK SMEs

    OpenAIRE

    Jones, Stephen; Noppen, Joost; Lettice, Fiona

    2016-01-01

    The DevOps phenomenon is gathering pace as more UK organisations seek to leverage the benefits it can potentially bring to software engineering functions. However substantial organisational change is inherent to adopting DevOps, especially where there are prior and established methods. As part of a wider piece of doctoral research investigating the management challenges of DevOps adoption, we present early findings of a six month qualitative diary study following the adoption of DevOps within...

  14. How to Form a Food Co-op.

    Science.gov (United States)

    Dodge, Philip; And Others

    Based on questions asked during an adult education course at Truman College (Chicago), this booklet was designed to be a simple organizing manual for small neighborhood preorder food cooperatives (co-ops). The guide covers basic information for organizing a co-op, definition of a co-op, what jobs are needed, getting the food, wholesale sources,…

  15. Shostakovich: Six Romances on Japanese Poems, Op. 21 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1996-01-01

    Uuest heliplaadist "Shostakovich: Six Romances on Japanese Poems, Op. 21. Six Poems of Marina Tsvetayeva, Op. 143. Suite on Verses of Michelangelo, Op. 145. Gothenburg Symphony Orchestra, Neeme Järvi. DG 447 085-2GH (71 minutes:DDD)

  16. Methodiek doorlichting VROM-beleid: op zoek naar publieke belangen

    NARCIS (Netherlands)

    Baarsma, B.E.; Laverman, F.; Hof, B.J.F.; Theeuwes, J.J.M.

    2007-01-01

    Het reduceren van de regeldruk staat al enige jaren hoog op de politieke agenda. Ook het huidige kabinet zal - als we afgaan op het Coalitieakkoord - de komende jaren inzetten op het reduceren van de regeldruk en administratieve lasten voor bedrijven en bur­gers. Het ministerie van VROM anticipeert

  17. Effecten van hakhoutbeheer op de vlinders van hellingbossen.

    NARCIS (Netherlands)

    Wallis de Vries, M.F.; Prick, M.J.M.

    2012-01-01

    In 2009 vond een verkennend onderzoek plaats naar de invloed van hakhoutbeheer op dag- en nachtvlinders in het Oombos en het Schaelsbergerbos bij Schin op Geul. Hierbij werden gedurende zeven nachten gegevens over nachtvlinders verzameld en op vier dagen gegevens over dagvlinders. Daarbij vertoonden

  18. How to Form a Food Co-op.

    Science.gov (United States)

    Dodge, Philip; And Others

    Based on questions asked during an adult education course at Truman College (Chicago), this booklet was designed to be a simple organizing manual for small neighborhood preorder food cooperatives (co-ops). The guide covers basic information for organizing a co-op, definition of a co-op, what jobs are needed, getting the food, wholesale sources,…

  19. Shostakovich: Six Romances on Japanese Poems, Op. 21 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1996-01-01

    Uuest heliplaadist "Shostakovich: Six Romances on Japanese Poems, Op. 21. Six Poems of Marina Tsvetayeva, Op. 143. Suite on Verses of Michelangelo, Op. 145. Gothenburg Symphony Orchestra, Neeme Järvi. DG 447 085-2GH (71 minutes:DDD)

  20. Procesevaluatie van de Aggression Regulation Training op Nederlandse scholen

    NARCIS (Netherlands)

    Plaisier, J.; Ditzhuijzen, J. van; Wiersema, D.

    2011-01-01

    Op initiatief van het ministerie van Veiligheid en Justitie is de in Amerika ontwikkelde Agression Regulation Training (ART) op kleine schaal getest op negen Nederlandse scholen in drie steden. Het doel daarvan is het tegengaan van agressief gedrag in een vroeg stadium en het reduceren van geweldscr

  1. Kamperen als neventak : een onderzoek op Zeeuwse landbouwbedrijven

    NARCIS (Netherlands)

    Voskuilen, M.J.; Elk, van C.M.

    1989-01-01

    Rapport over het bedrijfseconomisch belang van een kampeergelegenheid als neventak op een agrarisch bedrijf en de invloed van deze vorm van verblijfsrecreatie op de ontwikkeling van de landbouwsector in Zeeland. Het rapport biedt daarnaast een profiel van de landbouw- en kampeertak op de bedrijven v

  2. 14th SpaceOps Conference

    CERN Document Server

    Schmidhuber, Michael; Lee, Young; Kim, Bangyeop

    2017-01-01

    This book includes a selection of 30 reviewed and enhanced manuscripts published during the 14th SpaceOps Conference held in May 2016 in Daejeon, South Korea. The selection was driven by their quality and relevance to the space operations community. The papers represent a cross-section of three main subject areas: · Mission Management – management tasks for designing, preparing and operating a particular mission. · Spacecraft Operations – preparation and implementation of all activities to operate a space vehicle (crewed and uncrewed) under all conditions. · Ground Operations – preparation, qualification, and operations of a mission dedicated ground segment and appropriate infrastructure including antennas, control centers, and communication means and interfaces. This book promotes the SpaceOps Committee’s mission to foster the technical interchange on all aspects of space mission operations and ground data systems while promoting and maintaining an international community of space operations exper...

  3. Joint SatOPS Compatibility Efforts

    Science.gov (United States)

    Smith, Danford

    2010-01-01

    This slide presentation reviews NASA Goddard Space Flight Center's (GSFC) participation in the interagency cooperation committee, the Joint SatOps Compatibility Committee (JSCC), and the compatible Sat 2 efforts. Part of GSFC's participation in the JSCC is to work with the Goddard Mission Systems Evolution Center (GMSEC) to provides a publish/subscribe framework to enable rapid integration of commercially available satellite control products.

  4. Terugblik op psychosociale hulp na MH17.

    OpenAIRE

    2016-01-01

    De ramp met MH17 confronteerde duizenden Nederlanders, verspreid over het hele land, met het verlies van familieleden, vrienden, collega’s, klasgenoten, buren of verenigingsleden. De maatschappelijke betrokkenheid was groot. In deze bijdrage blikken we kort terug op het totale psychosociale nazorgprogramma dat sinds de ramp is ingezet in samenwerking met vele betrokkenen, waaronder de ministeries van Veiligheid en Justitie en Volksgezondheid, Welzijn en Sport. (aut. ref.)

  5. Cumulate Fragments in Silicic Ignimbrites

    Science.gov (United States)

    Bachmann, O.; Ellis, B. S.; Wolff, J.

    2014-12-01

    Increasingly, studies are concluding that silicic ignimbrites are the result of the amalgamation of multiple discrete magma batches. Yet the existence of discrete batches presents a conundrum for magma generation and storage; if silicic magma batches are not generated nearly in situ in the upper crust, they must traverse, and reside within, a thermally hostile environment with large temperature gradients, resulting in low survivability in their shallow magmatic hearths. The Snake River Plain (Idaho, USA) is a type example of this 'multi-batch' assembly with ignimbrites containing multiple populations of pyroxene crystals, glass shards, and crystal aggregates. The ubiquitous crystal aggregates hint at a mechanism to facilitate the existence of multiple, relatively small batches of rhyolite in the upper crust. These aggregates contain the same plagioclase, pyroxene, and oxide mineral compositions as single phenocrysts of the same minerals in their host rocks, but they have significantly less silicic bulk compositions and lack quartz and sanidine, which occur as single phenocrysts in the deposits. This implies significant crystallization followed by melt extraction from mushy reservoir margins. The extracted melt then continues to evolve (crystallizing sanidine and quartz) while the melt-depleted margins provide an increasingly rigid and refractory network segregating the crystal-poor batches of magma. The hot, refractory, margins insulate the crystal-poor lenses, allowing (1) extended residence in the upper crust, and (2) preservation of chemical heterogeneities among batches. In contrast, systems that produce cumulates richer in low-temperature phases (quartz, K-feldspars, and/or biotite) favour remelting upon recharge, leading to less segregation of eruptible melt pockets and the formation of gradationally zoned ignimbrites. The occurrence of similar crystal aggregates from a variety of magmatic lineages suggests the generality of this process.

  6. Operational Risk Management A Practical Approach to Intelligent Data Analysis

    CERN Document Server

    Kenett, Ron

    2010-01-01

    The book will introduce modern Operational Risk (OpR) Management and illustrates the various sources of OpR assessment and OpR mitigation. This book discusses how various data sources can be integrated and analyzed and how OpR is synergetic to other risk management activities such as Financial Risk Management and Internationalization. The topics will include state of the art technology such as semantic analysis, ontology engineering, data mining and statistical analysis.

  7. Cumulative human impacts on marine predators

    DEFF Research Database (Denmark)

    Maxwell, Sara M; Hazen, Elliott L; Bograd, Steven J

    2013-01-01

    Stressors associated with human activities interact in complex ways to affect marine ecosystems, yet we lack spatially explicit assessments of cumulative impacts on ecologically and economically key components such as marine predators. Here we develop a metric of cumulative utilization and impact...

  8. Cumulative dietary exposure of the population of Denmark to pesticides

    DEFF Research Database (Denmark)

    Jensen, Bodil Hamborg; Petersen, Annette; Nielsen, Elsa

    2015-01-01

    We used the Hazard Index (HI) method to carry out a cumulative risk assessment after chronic dietary exposure to all monitored pesticides in fruit, vegetables and cereals for various consumer groups in Denmark. Residue data for all the pesticides were obtained from the Danish monitoring programme...... that included processing factors and set non-detects to ½ LOR, but limited the correction (Model 3), gave the most realistic exposure estimate. With Model 3 the HI was calculated to be 0.44 for children and 0.18 for adults, indicating that there is no risk of adverse health effects following chronic cumulative...... exposure to the pesticides found in fruit, vegetables and cereals on the Danish market. The HI was below 1 even for consumers who eat more than 550 g of fruit and vegetables per day, corresponding to 1/3 of the population. Choosing Danish-produced commodities whenever possible could reduce the HI...

  9. MENINGKATKAN AKTIVITAS HASIL BELAJAR MENGELOLA KONFLIK DENGAN CO-OP CO-OP

    Directory of Open Access Journals (Sweden)

    Ilman Nafia

    2016-03-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui peningkatan hasil belajar konsumsi dengan menggunakan kooperatif tipe co-op co-op siswa kelas X BB 2 SMK NU 01 Kendal. Penelitian ini merupakan penelitian tindakan kelas. Lokasi penelitian dilaksanakan di SMK NU 01, Kota Kendal. Subyek dalam penelitian ini adalah kelas X BB 2. Berdasarkan hasil penelitian diperoleh nilai rata-rata hasil belajar siswa pada siklus I sebesar 74,11 dengan ketuntasan klasikal 71,63%. Sedangkan nilai rata-rata hasil belajar siklus II sebesar 83,04 dengan ketuntasan klasikal 87,84%. Hasil pengamatan aktivitas siswa menunjukkan adanya peningkatan aktivitas belajar siswa, siklus I diperoleh hasil sebesar 65% meningkat menjadi 87,49% pada siklus II, sedangkan aktivitas guru siklus I sebesar 62,5% meningkat menjadi 84,37% pada siklus II. Hal ini menunjukkan adanya peningkatan hasil belajar siswa dengan menggunakan kooperatif tipe co-op co-op pada materi mengelola konflik. Saran yang berkaitan dengan hasil penelitian adalah perlu adanya kesiapan guru sebelum memulai pelajaran, guru hendaknya mampu menguasai kelas dengan baik agar siswa lebih aktif, dan memilih metode yang tepat untuk diterapkan dalam proses belajar mengajar. The purpose of this study was to determine the increase in activity and learning outcomes with the content managing conflict of cooperative learning type co-op co-op students of class X BB 2 SMK NU 01 Kendal. This research is a class act. Location of the study conducted a SMK NU 01 Kendal, Kendal. The subjects in this study were class X BB 2. The result showed the average value of student learning outcomes in the first cycle of 74,11 to 71,63% classical completeness. While the average value of the second cycle of learning outcomes by 83,04 to 87,84% classical completeness. Observations of student activity showed an increase students' learning activities, cycle I obtained a yield of 65% increased to 87,49% in the second cycle, while the activity of the first

  10. Software Development with DevOps

    OpenAIRE

    Kristinsson, Rögnvaldur

    2015-01-01

    The goal of the study was to introduce DevOps in software development, its methods and approaches to software development. I was introduced to the subject by one of my teach-ers, which let me into further studies and researched on the subject and finally choosing it for the study. The subject was completely new to me when I started the study which I found inspirational as I was learning a new and an interesting subject on a daily basis dur-ing the process of writing the study. The materia...

  11. The Evaluation of Epiphyseal Plate Histological Changes in Osteopetrotic op/op Mice.

    Directory of Open Access Journals (Sweden)

    Aligholi Sobhani

    2003-09-01

    Full Text Available This study was designed for evaluation of epiphyseal plate histological changes of femur bones in osteopetrotic op/op mice.In this study 5 osteopetrotic op/op mice which were purchased from the commercial source were used.The animals were killed by overdose of chloroform and their femur bones were extracted. The bones were fixed in 10% formaldehyde and decalcified by HCl (0.6N, and routine histological processing were performed. The sections were stained by H&E methods and studied by conventional light microscopy. The results showed that, proliferative zone (PZ and especially hypertrophic zone (HZ were much thickened. In the ossification zone, trabecular bones were irregular and atypical osteoblast cells were observed. The osteoclast cells were not attached to trabecular bones. The bone marrow cavity was restricted and bone marrow cells were poor and scattered. Findings of the present investigation are similar to those reported about epiphyseal plate in osteosclerotic (OC mice in which epiphyseal plate especially hypertrophic zone was thickened and chondrocytes were not substituted for osteoblasts in calcified cartilage area. Also, osteoclast cells had been inactive or absent in OC mice. For prevention of other complication due to the epiphyseal plate changes in new borne, suitable and punctually treatment protocols such as prescription of Macrophage Colony Stimulating-Factor (MCS-F could be useful.

  12. Gekombineerde selektie op melk en vlees bij MRIJ levert geld op.

    NARCIS (Netherlands)

    Oldenbroek, J.K.; Bekman, H.; Koorn, D.; Werf, van der J.H.J.; Veldhuizen, van A.

    1990-01-01

    Aan de hand van de meest recente resultaten van een dubbeldoelproef wordt ingegaan op drie vragen : kan een melkvaars tegelijkertijd melk en vlees produceren; kan een stier, die dochters voortbrengt met een hoge melkproduktie, stierkalveren voortbrengen die gunstige eigenschappen hebben voor de kalf

  13. Conflict en compassie: een hedendaagse blik op Wagner en een wagneriaanse blik op onszelf

    NARCIS (Netherlands)

    Keestra, M.; Helmers, R.; Westbroek, P.

    2014-01-01

    Richard Wagner was niet alleen een uitzonderlijke componist en auteur maar ook een activist die zijn ogen op de toekomst gericht had. Dat lijkt verbazingwekkend gezien het feit dat zijn opera’s veelal plaatsvinden in historische en zelfs mythologische tijden. Zijn activisme blijkt bijvoorbeeld uit d

  14. Effecten van de ontwikkeling van de luchtvaart op Lelystad Airport op voedselkwaliteit

    NARCIS (Netherlands)

    Rietra, R.P.J.J.; Romkens, P.F.A.M.

    2014-01-01

    Voor de milieueffectrapportage Lelystad Airport is een bureaustudie gedaan naar de effecten van de ontwikkeling van de luchthaven op de kwaliteit van de landbouwproducten. Anders dan bij andere Nederlandse luchthavens, zijn er in de omgeving van Lelystad Airport veel teelten van verse bovengrondse p

  15. Nonlinear cumulative damage model for multiaxial fatigue

    Institute of Scientific and Technical Information of China (English)

    SHANG De-guang; SUN Guo-qin; DENG Jing; YAN Chu-liang

    2006-01-01

    On the basis of the continuum fatigue damage theory,a nonlinear uniaxial fatigue cumulative damage model is first proposed.In order to describe multiaxial fatigue damage characteristics,a nonlinear multiaxial fatigue cumulative damage model is developed based on the critical plane approach,The proposed model can consider the multiaxial fatigue limit,mean hydrostatic pressure and the unseparated characteristic for the damage variables and loading parameters.The recurrence formula of fatigue damage model was derived under multilevel loading,which is used to predict multiaxial fatigue life.The results showed that the proposed nonlinear multiaxial fatigue cumulative damage model is better than Miner's rule.

  16. Performance-oriented DevOps: A Research Agenda

    OpenAIRE

    Brunnert, Andreas; van Hoorn, Andre; Willnecker, Felix; Danciu, Alexandru; Hasselbring, Wilhelm; Heger, Christoph; Herbst, Nikolas; Jamshidi, Pooyan; Jung, Reiner; von Kistowski, Joakim; Koziolek, Anne; Kroß, Johannes; Spinner, Simon; Vögele, Christian; Walter, Jürgen

    2015-01-01

    DevOps is a trend towards a tighter integration between development (Dev) and operations (Ops) teams. The need for such an integration is driven by the requirement to continuously adapt enterprise applications (EAs) to changes in the business environment. As of today, DevOps concepts have been primarily introduced to ensure a constant flow of features and bug fixes into new releases from a functional perspective. In order to integrate a non-functional perspective into these DevOps concepts th...

  17. Cumulative cultural learning: Development and diversity.

    Science.gov (United States)

    Legare, Cristine H

    2017-07-24

    The complexity and variability of human culture is unmatched by any other species. Humans live in culturally constructed niches filled with artifacts, skills, beliefs, and practices that have been inherited, accumulated, and modified over generations. A causal account of the complexity of human culture must explain its distinguishing characteristics: It is cumulative and highly variable within and across populations. I propose that the psychological adaptations supporting cumulative cultural transmission are universal but are sufficiently flexible to support the acquisition of highly variable behavioral repertoires. This paper describes variation in the transmission practices (teaching) and acquisition strategies (imitation) that support cumulative cultural learning in childhood. Examining flexibility and variation in caregiver socialization and children's learning extends our understanding of evolution in living systems by providing insight into the psychological foundations of cumulative cultural transmission-the cornerstone of human cultural diversity.

  18. Calculating Cumulative Binomial-Distribution Probabilities

    Science.gov (United States)

    Scheuer, Ernest M.; Bowerman, Paul N.

    1989-01-01

    Cumulative-binomial computer program, CUMBIN, one of set of three programs, calculates cumulative binomial probability distributions for arbitrary inputs. CUMBIN, NEWTONP (NPO-17556), and CROSSER (NPO-17557), used independently of one another. Reliabilities and availabilities of k-out-of-n systems analyzed. Used by statisticians and users of statistical procedures, test planners, designers, and numerical analysts. Used for calculations of reliability and availability. Program written in C.

  19. New Wavelet Bases and Isometric Between Symbolic Operators Spaces OpS1,δm and Kernel Distributions Spaces

    Institute of Scientific and Technical Information of China (English)

    YANG Qi Xiang

    2002-01-01

    In the fifties, Calderón established a formal relation between symbol and kernel distribu-the C-Z operators, and Hormander, Kohn and Nirenberg, et al. studied the symbolic operators. Herewe apply a refinement of the Littlewood-Paley (L-P) decomposition, analyse under new wavelet bases,to characterize both symbolic operators spaces OpS1,δm and kernel distributions spaces with other spacescomposed of some almost diagonal matrices, then get an isometric between OpS1,δm and kernel distri-bution spaces

  20. Cumulative cultural evolution: the role of teaching.

    Science.gov (United States)

    Castro, Laureano; Toro, Miguel A

    2014-04-21

    In humans, cultural transmission occurs usually by cumulative inheritance, generating complex adaptive behavioral features. Cumulative culture requires key psychological processes (fundamentally imitation and teaching) that are absent or impoverished in non-human primates. In this paper we analyze the role that teaching has played in human cumulative cultural evolution. We assume that a system of cumulative culture generates increasingly adaptive behaviors, that are also more complex and difficult to imitate. Our thesis is that, as cultural traits become more complex, cumulative cultural transmission requires teaching to ensure accurate transmission from one generation to the next. In an increasingly complex cultural environment, we consider that individuals commit errors in imitation. We develop a model of cumulative cultural evolution in a changing environment and show that these errors hamper the process of cultural accumulation. We also show that a system of teaching between parents and offspring that increases the fidelity of imitation unblocks the accumulation and becomes adaptive whenever the gain in fitness compensates the cost of teaching.

  1. Human cumulative culture: a comparative perspective.

    Science.gov (United States)

    Dean, Lewis G; Vale, Gill L; Laland, Kevin N; Flynn, Emma; Kendal, Rachel L

    2014-05-01

    Many animals exhibit social learning and behavioural traditions, but human culture exhibits unparalleled complexity and diversity, and is unambiguously cumulative in character. These similarities and differences have spawned a debate over whether animal traditions and human culture are reliant on homologous or analogous psychological processes. Human cumulative culture combines high-fidelity transmission of cultural knowledge with beneficial modifications to generate a 'ratcheting' in technological complexity, leading to the development of traits far more complex than one individual could invent alone. Claims have been made for cumulative culture in several species of animals, including chimpanzees, orangutans and New Caledonian crows, but these remain contentious. Whilst initial work on the topic of cumulative culture was largely theoretical, employing mathematical methods developed by population biologists, in recent years researchers from a wide range of disciplines, including psychology, biology, economics, biological anthropology, linguistics and archaeology, have turned their attention to the experimental investigation of cumulative culture. We review this literature, highlighting advances made in understanding the underlying processes of cumulative culture and emphasising areas of agreement and disagreement amongst investigators in separate fields.

  2. Did the Olympics need more drugs? a doctor's reflection on providing medical care during Op OLYMPICS.

    Science.gov (United States)

    Monteiro de Barros, James; Ross, D A

    2014-09-01

    This paper examines some of the medical problems arising from the successful deployment of Defence Medical Services personnel to Op OLYMPICS (mid-June 2012-September 2012). It does not aim to be all encompassing in its scope, but focuses on the most pressing issues affecting a junior military doctor's ability to work effectively under field conditions. This will entail a discussion about whether in a deployment such as Op OLYMPICS medical care should be based upon offering solely primary healthcare in medical centres or using Role 1 medical treatment facilities, which include primary healthcare and pre-hospital emergency care. The main recommendations arising from the deployment are: clinicians should deploy with a minimum of basic emergency drugs and equipment; a medical facility treating a large population at risk for a prolonged period should have a broad stock of medications available on site; and medical risk assessments must be performed on all Reservists during mobilisation.

  3. Op die grens van vakwetenskap en filosofie

    Directory of Open Access Journals (Sweden)

    M Elaine Botha

    1976-03-01

    Full Text Available Die begrip “grens” soos dit voorkom in die titel is vir meerdere uitleg vatbaar. Eerstens sou dit kon dui op ’n onoorskreibare punt tussen die filosofie en die vakwetenskappe, so iets soos ’n grenspaal of baken, met ander woorde ’n punt van waterdigte skeiding tussen die domein van die filosofie en die vakwetenskappe. As ’n mens soms die dramatiese grensgevegte tussen die filo­ sofie en die vakwetenskappe in die wetenskaplike literatuur beskou1 dan blyk dit kennelik noodsaaklik te wees om wel sodanige grens te stel, veral ten einde die gevaar van weten­ skaplike terrorisme van die een of die ander kant die hoof te bied.

  4. Tera-Ops Processing for ATR

    Science.gov (United States)

    Udomkesmalee, Suraphol; Padgett, Curtis; Zhu, David; Lung, Gerald; Howard, Ayanna

    2000-01-01

    A three-dimensional microelectronic device (3DANN-R) capable of performing general image convolution at the speed of 1012 operations/second (ops) in a volume of less than 1.5 cubic centimeter has been successfully built under the BMDO/JPL VIGILANTE program. 3DANN-R was developed in partnership with Irvine Sensors Corp., Costa Mesa, California. 3DANN-R is a sugar-cube-sized, low power image convolution engine that in its core computation circuitry is capable of performing 64 image convolutions with large (64x64) windows at video frame rates. This paper explores potential applications of 3DANN-R such as target recognition, SAR and hyperspectral data processing, and general machine vision using real data and discuss technical challenges for providing deployable systems for BMDO surveillance and interceptor programs.

  5. VEP Responses to Op-Art Stimuli.

    Directory of Open Access Journals (Sweden)

    Louise O'Hare

    Full Text Available Several types of striped patterns have been reported to cause adverse sensations described as visual discomfort. Previous research using op-art-based stimuli has demonstrated that spurious eye movement signals can cause the experience of illusory motion, or shimmering effects, which might be perceived as uncomfortable. Whilst the shimmering effects are one cause of discomfort, another possible contributor to discomfort is excessive neural responses: As striped patterns do not have the statistical redundancy typical of natural images, they are perhaps unable to be encoded efficiently. If this is the case, then this should be seen in the amplitude of the EEG response. This study found that stimuli that were judged to be most comfortable were also those with the lowest EEG amplitude. This provides some support for the idea that excessive neural responses might also contribute to discomfort judgements in normal populations, in stimuli controlled for perceived contrast.

  6. VEP Responses to Op-Art Stimuli.

    Science.gov (United States)

    O'Hare, Louise; Clarke, Alasdair D F; Pollux, Petra M J

    2015-01-01

    Several types of striped patterns have been reported to cause adverse sensations described as visual discomfort. Previous research using op-art-based stimuli has demonstrated that spurious eye movement signals can cause the experience of illusory motion, or shimmering effects, which might be perceived as uncomfortable. Whilst the shimmering effects are one cause of discomfort, another possible contributor to discomfort is excessive neural responses: As striped patterns do not have the statistical redundancy typical of natural images, they are perhaps unable to be encoded efficiently. If this is the case, then this should be seen in the amplitude of the EEG response. This study found that stimuli that were judged to be most comfortable were also those with the lowest EEG amplitude. This provides some support for the idea that excessive neural responses might also contribute to discomfort judgements in normal populations, in stimuli controlled for perceived contrast.

  7. Cumulative effects of planned industrial development and climate change on marine ecosystems

    Directory of Open Access Journals (Sweden)

    Cathryn Clarke Murray

    2015-07-01

    Full Text Available With increasing human population, large scale climate changes, and the interaction of multiple stressors, understanding cumulative effects on marine ecosystems is increasingly important. Two major drivers of change in coastal and marine ecosystems are industrial developments with acute impacts on local ecosystems, and global climate change stressors with widespread impacts. We conducted a cumulative effects mapping analysis of the marine waters of British Columbia, Canada, under different scenarios: climate change and planned developments. At the coast-wide scale, climate change drove the largest change in cumulative effects with both widespread impacts and high vulnerability scores. Where the impacts of planned developments occur, planned industrial and pipeline activities had high cumulative effects, but the footprint of these effects was comparatively localized. Nearshore habitats were at greatest risk from planned industrial and pipeline activities; in particular, the impacts of planned pipelines on rocky intertidal habitats were predicted to cause the highest change in cumulative effects. This method of incorporating planned industrial development in cumulative effects mapping allows explicit comparison of different scenarios with the potential to be used in environmental impact assessments at various scales. Its use allows resource managers to consider cumulative effect hotspots when making decisions regarding industrial developments and avoid unacceptable cumulative effects. Management needs to consider both global and local stressors in managing marine ecosystems for the protection of biodiversity and the provisioning of ecosystem services.

  8. Geen effect aujeszky-enting op de technische resultaten

    NARCIS (Netherlands)

    Bakker, J.

    1991-01-01

    Op dit moment worden alleen gl-negatieve vaccins gebruikt. Dit om onderscheid te kunnen maken tussen de antistoffen gemaakt door het vaccin en het veldvirus, dat de ziekte van Aujeszky veroorzaakt. Het onderzoek is toen uitgevoerd op het Varkensproefbedrijf te Sterksel om de gevolgen van de

  9. Beethoven, Ludwig van: Violinkonzert D-Dur op. 61

    Index Scriptorium Estoniae

    1997-01-01

    Uuest heliplaadist "Beethoven, Ludwig van: Violinkonzert D-Dur op. 61 (Kadenz: Alfred Schnittke). Romanzen für Violine und Orchester op. 40 und 50. Estonian National Symphony Orchestra, Arvo Volmer". Globe GLO 5155, distribution Talis (CD:153F). 1996. TT:1h 01'56"

  10. OPS index - KOME | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...listed. Data file File name: kome_ops_index.zip File URL: ftp://ftp.biosciencedbc.jp/archive/kome/LATEST/kom...e History of This Database Site Policy | Contact Us OPS index - KOME | LSDB Archive ...

  11. Factoren die van invloed zijn op enkele vruchtbaarheidskenmerken van zeugen.

    NARCIS (Netherlands)

    Klaver, J.; den Hartog, L.A.

    1989-01-01

    Gegevens van meerdere worpen van 358 zeugen Groot Yorkshire en Nederlands Landras zijn gebruikt om verbanden tussen produktiekenmerken te berekenen. Ingegaan wordt op de invloed van het voerniveau tijdens de zoogperiode en tijdens het interval van spenen tot dekken op diverse variabelen, die van bel

  12. Het effect van suikervrije (functionele) kauwgom op plaque en gingivitis

    NARCIS (Netherlands)

    Keukenmeester, R.S.; Slot, D.E.; van der Weijden, G.A.

    2013-01-01

    Het doel van twee systematische literatuuronderzoeken was het onderzoeken van het effect van suikervrije (functionele) kauwgom op plaque en klinische parameters van gingivitis. Studie 1 onderzocht het effect op plaque en gingivitis van suikervrije kauwgom ten opzichte van geen kauwgomgebruik. Studie

  13. 2011 Internship & Co-Op Survey. Research Brief

    Science.gov (United States)

    National Association of Colleges and Employers (NJ1), 2011

    2011-01-01

    The National Association of Colleges and Employers' (NACE's) "2011 Internship & Co-op Survey" indicates that internships are an integral and ever-important part of the college recruiting scene. The survey finds that employers expect to increase internship hiring by about 7 percent this year and co-op positions by nearly 9 percent. Furthermore,…

  14. Beoordeling gezondheidsrisico's door sporten op kunstgrasvelden met rubbergranulaat

    NARCIS (Netherlands)

    Oomen AG; de Groot GM; CPV; M&V

    2016-01-01

    Uit nieuw onderzoek van het RIVM blijkt dat het risico voor de gezondheid van sporten op kunstgrasvelden die zijn ingestrooid met rubbergranulaat, praktisch verwaarloosbaar is. Dat betekent dat het verantwoord is om op deze velden te sporten. Aanleiding voor het onderzoek is de maatschappelijke

  15. Overheden bereid extra te betalen voor auto's op alternatieve brandstof

    NARCIS (Netherlands)

    Rijnsoever, F.J. van; Hagen, Paul

    2012-01-01

    De elektrische auto en een auto op groen gas worden door overheden hoger gewaardeerd dan de auto met reguliere verbrandingsmotor. Bovendien zijn overheden bereid extra te betalen voor een auto op alternatieve brandstof. Dit blijkt uit een masteronderzoek van de Universiteit Utrecht in opdracht

  16. Monovergisting varkensmest op boerderijschaal = Fermenting pig manure on farm scale

    NARCIS (Netherlands)

    Kasper, G.J.; Peters, B.

    2012-01-01

    Technische en economische berekeningen van vergisting van varkensmest zonder en met glycerine zijn weergegeven na praktijkproeven op boerderijschaal op VIC Sterksel met twee monovergisters, een mini-WKK (MAN, 60 kW) en een minigasturbine (Capstone, 60 kW). De Microferm van HoSt en de UDR-fermenter

  17. Aspecten van het beheer van Wilde zwijnen op de Veluwe

    NARCIS (Netherlands)

    Groot Bruinderink, G.W.T.A.; Lammertsma, D.R.

    2008-01-01

    Eens in de zoveel jaren, zoals afgelopen winter, zijn er veel berichten over overlast veroorzakende wilde zwijnen op de Veluwe. Welke factoren hebben geleid tot de enorme toename van de Sus scrofa? Op basis van kennis van de relatie tussen het wilde zwijn en mast worden een aantal mogelijke beheersc

  18. Gezondheidsclaims voor kruidenpreparaten op basis van Ginkgo biloba

    NARCIS (Netherlands)

    Pelgrom SMGJ; Fransen HP; Rompelberg CJM; de Rooij EK; Pronk MEJ; Baars AJ; de Kaste D; Verhagen H; SIR; CVG; KCF

    2007-01-01

    Er is onvoldoende bewijs voor drie geclaimde gezondheidseffecten bij het gebruik van kruidenpreparaten op basis van de Japanse notenboom Ginkgo biloba. Ook toont een analyse van 29 Ginkgo-preparaten aan dat het merendeel niet bevat wat op het etiket vermeld staat. Daarnaast kan bij de aanbevolen d

  19. Buienradar brengt kans op extreme regenval in kaart

    NARCIS (Netherlands)

    Overeem, A.

    2010-01-01

    De KNMI-neerslagradars maken elke vijf minuten scans over heel Nederland, waarna vrijwel gelijk de neerslagintensiteitsbeelden kunnen worden bekeken op internet. Aangetoond is dat deze buienradars ook geschikt zijn om de kans op extreme hoeveelheden neerslag te bepalen. Handige informatie voor de

  20. De renaissance van arbeidskunde: Productiviteit op bouwplaats lager dan 50%!

    NARCIS (Netherlands)

    Pries, Frens; Brokelman, L.

    2009-01-01

    Een kleine 40 jaar geleden onderging de bouw een ware revolutie. De seriematige productie van casco’s werd tot kunst verheven. Kern van deze revolutie was een tot in detail doordachte organisatie van het werk op de bouwplaats. En, conform het aloude adagio ‘meten is weten’, was dat weer gebaseerd op

  1. Prestatiemeting op de werkvloer van Grolsch: een participatieve aanpak

    NARCIS (Netherlands)

    Stertefeld, T.; Wilderom, C.P.M.; Wouters, M.J.F.

    2009-01-01

    Sinds 2002 is bij Grolsch een nieuwe aanpak voor prestatiemeting in ontwikkeling. Gestart is met de logistieke processen. Het uitgangspunt is om prestatiemeting niet alleen te richten op het hogere management, maar om medewerkers op alle niveaus meer inzicht te laten krijgen in hun processen en pres

  2. Jeroen Wildschut : Besparen op energie bij bewaren gaat goed'

    NARCIS (Netherlands)

    Dwarswaard, A.; Wildschut, J.

    2009-01-01

    Door het ethyleen te meten kan bij de bewaring flink op energie worden bespaard, omdat er minder lucht nodig is. PPO-onderzoeker Jeroen Wildschut is betrokken bij het project State-of-the-Art, waar bedrijven nagaan wat er mogelijk is op het terrein van energiebesparing. Jeroen Wildschut ziet nog vee

  3. Beethoven, Ludwig van: Violinkonzert D-Dur op. 61

    Index Scriptorium Estoniae

    1997-01-01

    Uuest heliplaadist "Beethoven, Ludwig van: Violinkonzert D-Dur op. 61 (Kadenz: Alfred Schnittke). Romanzen für Violine und Orchester op. 40 und 50. Estonian National Symphony Orchestra, Arvo Volmer". Globe GLO 5155, distribution Talis (CD:153F). 1996. TT:1h 01'56"

  4. Ground-Truthing Validation to Assess the Effect of Facility Locational Error on Cumulative Impacts Screening Tools

    OpenAIRE

    Sadd, J. L.; Hall, E. S.; Pastor, M.; Morello-Frosch, R. A.; D. Lowe-Liang; Hayes, J.; Swanson, C

    2015-01-01

    Researchers and government regulators have developed numerous tools to screen areas and populations for cumulative impacts and vulnerability to environmental hazards and risk. These tools all rely on secondary data maintained by government agencies as part of the regulatory and permitting process. Stakeholders interested in cumulative impacts screening results have consistently questioned the accuracy and completeness of some of these datasets. In this study, three cumulative impacts screenin...

  5. Roussel. Sinfonien Nr. 3 g-Moll op. 42 und Nr. 4 A-Dur op. 5, Neeme Järvi / Christoph Schlüren

    Index Scriptorium Estoniae

    Schlüren, Christoph

    1995-01-01

    Uuest heliplaadist "Roussel. Sinfonien Nr. 3 g-Moll op. 42 und Nr. 4 A-Dur op. 53, Bacchus et Ariane op. 43 (Zweite Orchestersuite). Sinfonietta für Streichorchester d-Moll op. 52. Detroit Symphony Orchester, N. Järvi". Chandos/Koch CD 7007(WD: 70'10") DDD

  6. Roussel. Sinfonien Nr. 3 g-Moll op. 42 und Nr. 4 A-Dur op. 5, Neeme Järvi / Christoph Schlüren

    Index Scriptorium Estoniae

    Schlüren, Christoph

    1995-01-01

    Uuest heliplaadist "Roussel. Sinfonien Nr. 3 g-Moll op. 42 und Nr. 4 A-Dur op. 53, Bacchus et Ariane op. 43 (Zweite Orchestersuite). Sinfonietta für Streichorchester d-Moll op. 52. Detroit Symphony Orchester, N. Järvi". Chandos/Koch CD 7007(WD: 70'10") DDD

  7. Predicting Cumulative Incidence Probability by Direct Binomial Regression

    DEFF Research Database (Denmark)

    Scheike, Thomas H.; Zhang, Mei-Jie

    Binomial modelling; cumulative incidence probability; cause-specific hazards; subdistribution hazard......Binomial modelling; cumulative incidence probability; cause-specific hazards; subdistribution hazard...

  8. Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants.

    Directory of Open Access Journals (Sweden)

    Anders Borglykke

    Full Text Available AIM: To assess the individual and combined effect of 46 type 2 diabetes related risk alleles on incidence of a composite CVD endpoint. METHODS: Data from the first Danish MONICA study (N = 3523 and the Inter99 study (N = 6049 was used. Using Cox proportional hazard regression the individual effect of each risk allele on incident CVD was analyzed. Risk was presented as hazard ratios (HR per risk allele. RESULTS: During 80,859 person years 1441 incident cases of CVD (fatal and non-fatal occurred in the MONICA study. In Inter99 942 incident cases were observed during 61,239 person years. In the Danish MONICA study four gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154, C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0.0089, GCKR rs780094 (1.094, 1.007-1.188 , P = 0.0335 and C2CD4B rs11071657 (1.092, 1.007-1.183 , P = 0.0323. The genetic score was significantly associated with increased risk of CVD (1.025, 1.010-1.041, P = 0.0016. In Inter99 two gene variants were associated with risk of CVD independently of diabetes; SLC2A2 (HR 1.180, 95% CI 1.038-1.341 P = 0.0116 and FTO (0.909, 0.827-0.998, P = 0.0463. Analysing the two populations together we found SLC2A2 rs11920090 (HR 1.164, 95% CI 1.070-1.267, P = 0.0004 meeting the Bonferroni corrected threshold for significance. GCKR rs780094 (1.076, 1.010-1.146, P = 0.0229, C2CD4B rs11071657 (1.067, 1.003-1.135, P = 0.0385 and NOTCH2 rs10923931 (1.104 (1.001 ; 1.217 , P = 0.0481 were found associated with CVD without meeting the corrected threshold. The genetic score was significantly associated with increased risk of CVD (1.018, 1.006-1.031, P = 0.0043. CONCLUSIONS: This study showed that out of the 46 genetic variants examined only the minor risk allele of SLC2A2 rs11920090 was significantly (P = 0.0005 associated with a composite endpoint of incident CVD below the threshold for

  9. Rioolwateronderzoek op locaties met een verhoogde kans op import van wild poliovirus ; een pilot in drie asielzoekerscentra

    NARCIS (Netherlands)

    van der Avoort HGAM; Bijen M; Ras A; Koopmans MPG; van Loon AM; LIO; LIS

    1997-01-01

    Watermonsters, verkregen uit het riool op of nabij een drietal asielzoekerscentra werden onderzocht op de aanwezigheid van wild poliovirus, als experiment voor de surveillance van import van wild poliovirus in Nederland. In geen van de 73 monsters, die waren verkregen in een periode van vier maande

  10. Cumulative Culture and Future Thinking: Is Mental Time Travel a Prerequisite to Cumulative Cultural Evolution?

    Science.gov (United States)

    Vale, G. L.; Flynn, E. G.; Kendal, R. L.

    2012-01-01

    Cumulative culture denotes the, arguably, human capacity to build on the cultural behaviors of one's predecessors, allowing increases in cultural complexity to occur such that many of our cultural artifacts, products and technologies have progressed beyond what a single individual could invent alone. This process of cumulative cultural evolution…

  11. Addiction Risk Low for Seniors Taking Post-Op Opioids

    Science.gov (United States)

    ... explained Dr. Ruchi Sharma. She is a pain management specialist at Winthrop-University Hospital in Mineola, N.Y. However, addiction specialists also ... JAMA Surgery . SOURCES: Ruchi Sharma, M.D., pain management and ... Winthrop-University Hospital, Mineola, N.Y.; Harshal Kirane, M.D., director ...

  12. Identification and Quantification of Cumulative Factors that Increase Environmental Exposures and Impacts

    Science.gov (United States)

    Evaluating the combined adverse effects of multiple stressors upon human health is an imperative component of cumulative risk assessment (CRA)1. In addition to chemical stressors, other non-chemical factors are also considered. For examples, smoking will elevate the risks of havi...

  13. Cumulative phase delay imaging - A new contrast enhanced ultrasound modality

    Energy Technology Data Exchange (ETDEWEB)

    Demi, Libertario, E-mail: l.demi@tue.nl; Sloun, Ruud J. G. van; Mischi, Massimo [Lab. of Biomedical Diagnostics, Dept. of Electrical Eng., Eindhoven University of Technology (Netherlands); Wijkstra, Hessel [Lab. of Biomedical Diagnostics, Dept. of Electrical Eng., Eindhoven University of Technology (Netherlands); Academic Medical Center, Urology Dept., University of Amsterdam (Netherlands)

    2015-10-28

    Recently, a new acoustic marker for ultrasound contrast agents (UCAs) has been introduced. A cumulative phase delay (CPD) between the second harmonic and fundamental pressure wave field components is in fact observable for ultrasound propagating through UCAs. This phenomenon is absent in the case of tissue nonlinearity and is dependent on insonating pressure and frequency, UCA concentration, and propagation path length through UCAs. In this paper, ultrasound images based on this marker are presented. The ULA-OP research platform, in combination with a LA332 linear array probe (Esaote, Firenze Italy), were used to image a gelatin phantom containing a PVC plate (used as a reflector) and a cylindrical cavity measuring 7 mm in diameter (placed in between the observation point and the PVC plate). The cavity contained a 240 µL/L SonoVueO{sup ®} UCA concentration. Two insonating frequencies (3 MHz and 2.5 MHz) were used to scan the gelatine phantom. A mechanical index MI = 0.07, measured in water at the cavity location with a HGL-0400 hydrophone (Onda, Sunnyvale, CA), was utilized. Processing the ultrasound signals backscattered from the plate, ultrasound images were generated in a tomographic fashion using the filtered back-projection method. As already observed in previous studies, significantly higher CPD values are measured when imaging at a frequency of 2.5 MHz, as compared to imaging at 3 MHz. In conclusion, these results confirm the applicability of the discussed CPD as a marker for contrast imaging. Comparison with standard contrast-enhanced ultrasound imaging modalities will be the focus of future work.

  14. Is cumulated pyrethroid exposure associated with prediabetes?

    DEFF Research Database (Denmark)

    Hansen, Martin Rune; Jørs, Erik; Lander, Flemming;

    2014-01-01

    , cumulative exposure) was assessed from questionnaire data. Participants were asked about symptoms of diabetes. Blood samples were analyzed for glycosylated hemoglobin (HbA1c), a measure of glucose regulation. No association was found between pyrethroid exposure and diabetes symptoms. The prevalence...

  15. Cumulative Disadvantage among the Highly Ambitious.

    Science.gov (United States)

    McClelland, Katherine

    1990-01-01

    Using a social reproduction theory framework, analyzes the process by which high school seniors aspiring to high-level positions are sorted out after graduation. Analyzes early educational attainments and changes in occupational expectations. Shows a process of cumulative disadvantage in which White males are more likely to achieve their goals.…

  16. Pavlovian conditioning and cumulative reinforcement rate.

    Science.gov (United States)

    Harris, Justin A; Patterson, Angela E; Gharaei, Saba

    2015-04-01

    In 5 experiments using delay conditioning of magazine approach with rats, reinforcement rate was varied either by manipulating the mean interval between onset of the conditioned stimulus (CS) and unconditioned stimulus (US) or by manipulating the proportion of CS presentations that ended with the US (trial-based reinforcement rate). Both manipulations influenced the acquisition of responding. In each experiment, a specific comparison was made between 2 CSs that differed in their mean CS-US interval and in their trial-based reinforcement rate, such that the cumulative reinforcement rate-the cumulative duration of the CS between reinforcements-was the same for the 2 CSs. For example, a CS reinforced on 100% of trials with a mean CS-US interval of 60 s was compared with a CS reinforced on 33% of trials and a mean duration of 20 s. Across the 5 experiments, conditioning was virtually identical for the 2 CSs with matched cumulative reinforcement rate. This was true as long as the timing of the US was unpredictable and, thus, response rates were uniform across the length of the CS. We conclude that the effects of CS-US interval and of trial-based reinforcement rate are reducible entirely to their common effect on cumulative reinforcement rate. We discuss the implications of this for rate-based, trial-based, and real-time associative models of conditioning.

  17. An Axiomatization of Cumulative Prospect Theory

    NARCIS (Netherlands)

    Wakker, P.P.; Tversky, A.

    1993-01-01

    This paper presents a method for axiomatizing a variety of models for decision making under uncertainty, including Expected Utility and Cumulative Prospect Theory. This method identifies, for each model, the situations that permit consistent inferences about the ordering of value differences. Exampl

  18. Cumulative Disadvantage among the Highly Ambitious.

    Science.gov (United States)

    McClelland, Katherine

    1990-01-01

    Using a social reproduction theory framework, analyzes the process by which high school seniors aspiring to high-level positions are sorted out after graduation. Analyzes early educational attainments and changes in occupational expectations. Shows a process of cumulative disadvantage in which White males are more likely to achieve their goals.…

  19. Spinnen (Arachnida: Araneae) op akkers - biologie en plaagbestrijding

    NARCIS (Netherlands)

    Noordijk, J.; Helsdingen, van P.J.

    2007-01-01

    Spinnen vormen een soortenrijke groep van predatoren. In vrijwel geen terrestrisch habitattype ontbreken soorten uit deze orde. Door hun kolonisatiesnelheid en de diversiteit aan prooivangsttechnieken kunnen spinnen van groot belang zijn voor plaagbestrijding op akkers. In deze bijdrage behandelen w

  20. Het TNO-onderzoek op het gebied van de biotechnologie

    NARCIS (Netherlands)

    Thijssen, H.A.C.

    1982-01-01

    Bericht voor de persbijeenkomst op maandag 26 april 1982 in het kader van de 'toekomstige biotechnologie-activiteiten van TNO'. Prof Thijssen was voorzitter van de Dwarsverband biotechnologie TNO en directeur ITC.

  1. NOS CO-OPS Meteorological Data, Visibility, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Visibility data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  2. NOS CO-OPS Meteorological Data, Air Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Air Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  3. NOS CO-OPS Water Level Data, Verified, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  4. NOS CO-OPS Meteorological Data, Water Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Water Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  5. NOS CO-OPS Meteorological Data, Relative Humidity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Relative Humidity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  6. NOS CO-OPS Meteorological Data, Conductivity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Conductivity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  7. NOS CO-OPS Meteorological Data, Rain Fall, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Rain Fall data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  8. NOS CO-OPS Meteorological Data, Wind, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Wind data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been subjected...

  9. Kabalevsky, Violin Concerto in C major, Op. 48 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1991-01-01

    Uuest heliplaadist "Kabalevsky, Violin Concerto in C major, Op. 48. Khachaturian, Violin Concerto in D minor, Lydia Mordkovitch (violin). Royal Scottish National Orchestra /Neeme Järvi". Chandos MC ABTD 1519; CD CHAN 8918 (53 minutes)

  10. NOS CO-OPS Meteorological Data, Barometric Pressure, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Barometric Pressure data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  11. Op weg naar een robuuste, veerkrachtige gewasbescherming : Interview

    NARCIS (Netherlands)

    Staalduinen, van J.; Ramakers, P.M.J.; Meijer, R.J.M.

    2009-01-01

    Een robuuste, veerkrachtige gewasbescherming vergt een nadrukkelijker keuze voor minder kwetsbare gewassen, rassen en teeltsystemen. Daarnaast moet de beheersing van ziekten en plagen, zowel bovengronds als in bodem en in substraat, meer dan nu gebaseerd zijn op ecologische, zelfregulerende of

  12. R. Strauss: Symphonia domestica, Op. 53 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "R. Strauss: Symphonia domestica, Op. 53. National Youth Orchestra of Great Britain / Christopher Seaman. Pickwick IMP Classics CD PCD 1080; Selected comparisons: SNO, Järvi (3/88) Chandos CHAN 8572"

  13. De invloed van ervaring op de kwaliteit van het accountantsoordeel

    NARCIS (Netherlands)

    Nieuw Amerongen, van C.M. (Niels)

    2007-01-01

    In de jaren negentig van de vorige eeuw hebben de grootste accountantskantoren hun algemene controlemethodologie herzien naar een op bedrijfsrisico’s gebaseerde controlemethodologie. Onderscheidend aan deze controlemethodologie is dat specifieke aandacht wordt besteed aan begrippen als “bedrijfsrisi

  14. Her-entingen tegen Pseudo Vogelpest (NCD) op 'Het Spelderholt'

    NARCIS (Netherlands)

    Voorst, van A.

    1993-01-01

    Pseudo Vogelpest of NCD is een gevreesde virusziekte, waartegen een entverplichting geldt. Na het uitbreken van de ziekte in het zuiden van Nederland is al het volwassen pluimvee op Het Spelderholt opnieuw geënt.

  15. CO-OPS 1-minute Raw Tsunami Water Level Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CO-OPS has been involved with tsunami warning and mitigation since the Coast & Geodetic Survey started the Tsunami Warning System in 1948 to provide warnings to...

  16. NOS CO-OPS Water Level Data, Verified, Hourly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), hourly, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  17. NOS CO-OPS Active Currents Data, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has surface Active Currents data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These raw data have not...

  18. Alle ziekten op één DNA-chip

    NARCIS (Netherlands)

    Bonants, P.J.M.; Wubben, J.P.

    2001-01-01

    Universele test op alle ziekteverwekkers in ontwikkeling. Voor diverse virussen, bacteriën, schimmels en nematoden zijn snelle tests ontwikkeld met behulp van de PCR-techniek (Polymerase Chain Reaction)

  19. Alle ziekten op één DNA-chip

    NARCIS (Netherlands)

    Bonants, P.J.M.; Wubben, J.P.

    2001-01-01

    Universele test op alle ziekteverwekkers in ontwikkeling. Voor diverse virussen, bacteriën, schimmels en nematoden zijn snelle tests ontwikkeld met behulp van de PCR-techniek (Polymerase Chain Reaction)

  20. Screening op congenitale hypothyreoidie en fenylketonurie: overzicht gegevensverwerking per computer

    NARCIS (Netherlands)

    Loeber JG

    1984-01-01

    Dit rapport beschrijft in grote lijnen de automatisering van de gegevensverwerking van de screening op congenitale hypothyreoidie (CHT) en fenylketonurie (PKU) zoals toegepast bij de Bijzondere Afdeling Automatisering Serologisch Onderzoek (ASO). Het rapport is in hoofdzaak bedoeld als overzicht, n

  1. Shostakovich: Symphony N14, Op. 135 / Edward Greenfield

    Index Scriptorium Estoniae

    Greenfield, Edward

    1994-01-01

    Uuest heliplaadist "Shostakovich: Symphony N14, Op. 135; Mussorgsky: Songs and Dances of Death. Ljuba Kazarnovskaya (sop.), Brigitte Fassbaender (mez), Sergei Leiferkus (bar), Gothenburg Symphony Orchestra, Neeme Järvi" DG CD 437 785 - 2GH

  2. Shostakovich: Symphony N14, Op. 135 / Edward Greenfield

    Index Scriptorium Estoniae

    Greenfield, Edward

    1994-01-01

    Uuest heliplaadist "Shostakovich: Symphony N14, Op. 135; Mussorgsky: Songs and Dances of Death. Ljuba Kazarnovskaya (sop.), Brigitte Fassbaender (mez), Sergei Leiferkus (bar), Gothenburg Symphony Orchestra, Neeme Järvi" DG CD 437 785 - 2GH

  3. All Conservation Opportunity Areas (ECO.RES.ALL_OP_AREAS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The All_OP_Areas GIS layer are all the Conservation Opportunity Areas identified by MoRAP (produced for EPA Region 7). They designate areas with potential for...

  4. Het weblog als instrument voor reflectie op leren en handelen

    NARCIS (Netherlands)

    Wopereis, Iwan; Sloep, Peter

    2009-01-01

    Wopereis, I. G. J. H., & Sloep, P. B. (2009). Het weblog als instrument voor reflectie op leren en handelen [Kennisnet Essay]. Te verkrijgen via http://onderzoek.kennisnet.nl/onderzoeken/rendement/hetweblog

  5. R. Strauss: Symphonia domestica, Op. 53 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "R. Strauss: Symphonia domestica, Op. 53. National Youth Orchestra of Great Britain / Christopher Seaman. Pickwick IMP Classics CD PCD 1080; Selected comparisons: SNO, Järvi (3/88) Chandos CHAN 8572"

  6. Kabalevsky, Violin Concerto in C major, Op. 48 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1991-01-01

    Uuest heliplaadist "Kabalevsky, Violin Concerto in C major, Op. 48. Khachaturian, Violin Concerto in D minor, Lydia Mordkovitch (violin). Royal Scottish National Orchestra /Neeme Järvi". Chandos MC ABTD 1519; CD CHAN 8918 (53 minutes)

  7. Die groot avontuur – wondere van lewe op aarde

    Directory of Open Access Journals (Sweden)

    Barnie Barnard

    2007-09-01

    Full Text Available Leon Rousseau se Die groot avontuur is ’n populêre wetenskap oor die geskiedenis van lewe op aarde. Populêr-wetenskaplike tekste stel hoë eise aan die skrywer: aktualiteit, toeganklikheid van aanbieding, ’n getroue weergawe van persone en standpunte, duidelike onderskeid tussen feite, teorie en mening en bronne om al drie op te volg.

  8. CMOS technology and current-feedback op-amps

    DEFF Research Database (Denmark)

    Bruun, Erik

    1993-01-01

    Some of the problems related to the application of CMOS technology to current-feedback operational amplifiers (CFB op-amps) are identified. Problems caused by the low device transconductance and by the absence of matching between p-channel and n-channel transistors are examined, and circuit...... poor performance compared to the bipolar designs, but CMOS has a potential for CFB op-amp design if more ingenious circuit configurations are applied...

  9. Tera-Op Reliable Intelligently Adaptive Processing System (TRIPS)

    Science.gov (United States)

    2004-04-01

    AFRL-IF-WP-TR-2004-1514 TERA -OP RELIABLE INTELLIGENTLY ADAPTIVE PROCESSING SYSTEM (TRIPS) Stephen W. Keckler, Doug Burger, Michael Dahlin...03/31/2004 5a. CONTRACT NUMBER F33615-01-C-1892 5b. GRANT NUMBER 4. TITLE AND SUBTITLE TERA -OP RELIABLE INTELLIGENTLY ADAPTIVE PROCESSING...influence beyond the scope of this project; the influence is expected to increase with the fabrication of the prototype in phase 2. 1 2 Introduction The Tera

  10. Lig op Satan en Satanisme vanuit die Nuwe Testament

    Directory of Open Access Journals (Sweden)

    F. J. van Rensburg

    1992-06-01

    Full Text Available In hierdie artikel word, in aansluiting by en as voorsetting van prof. Vosloo se "Lig op Satanisme vanuit die Ou Testament" ook in die Nuwe Testament lig op die Satan en Satanisme-verskynsel gesoek. Wat die aard van die inhoud van hierdie artikel betref, probeer ek doelbewus om die stof só aan te bied dat dit gemaklik tot die gemiddelde ernstige Bybelleser kommunikeer. Derhalwe is die aanpak nie akademies-wetenskaplik nie, maar populêr-wetenskaplik.

  11. Continuous Integration, Deployment and Testing in DevOps Environment

    OpenAIRE

    Amaradri, Anand Srivatsav; Nutalapati, Swetha Bindu

    2016-01-01

    Context. Owing to a multitude of factors like rapid changes in technology, market needs, and business competitiveness, software companies these days are facing pressure to deliver software rapidly and on a frequent basis. For frequent and faster delivery, companies should be lean and agile in all phases of the software development life cycle. An approach called DevOps, which is based on agile principles has come into play. DevOps bridges the gap between development and operations teams and fa...

  12. Service Provider DevOps network capabilities and tools

    OpenAIRE

    Steinert, Rebecca; John, Wolfgang; Sköldström, Pontus; Pechenot, Bertrand; Gulyás, András; Pelle, István; Lévai, Tamás; Németh, Felicián; Kim, Juhoon; Meirosu, Catalin; Cai, Xuejun; Fu, Chunyan; Pentikousis, Kostas; Sharma, Sachin; Papafili, Ioanna

    2015-01-01

    This report provides an understanding of how the UNIFY Service Provider (SP)-DevOps concept can be applied and integrated with a combined cloud and transport network NFV architecture. Specifically, the report contains technical descriptions of a set of novel SP-DevOps tools and support functions that facilitate observability, troubleshooting, verification, and VNF development processes. The tools and support functions are described in detail together with their architectural mapping, giving a...

  13. Cumulative dietary exposure of the population of Denmark to pesticides.

    Science.gov (United States)

    Jensen, Bodil Hamborg; Petersen, Annette; Nielsen, Elsa; Christensen, Tue; Poulsen, Mette Erecius; Andersen, Jens Hinge

    2015-09-01

    We used the Hazard Index (HI) method to carry out a cumulative risk assessment after chronic dietary exposure to all monitored pesticides in fruit, vegetables and cereals for various consumer groups in Denmark. Residue data for all the pesticides were obtained from the Danish monitoring programme during the period 2004-2011. Food consumption data were obtained from DANSDA (the DAnish National Survey of Diet and physical Activity) for the period 2005-2008. The calculations were made using three different models to cope with residues below the limit of reporting (LOR). We concluded that a model that included processing factors and set non-detects to ½ LOR, but limited the correction (Model 3), gave the most realistic exposure estimate. With Model 3 the HI was calculated to be 0.44 for children and 0.18 for adults, indicating that there is no risk of adverse health effects following chronic cumulative exposure to the pesticides found in fruit, vegetables and cereals on the Danish market. The HI was below 1 even for consumers who eat more than 550 g of fruit and vegetables per day, corresponding to 1/3 of the population. Choosing Danish-produced commodities whenever possible could reduce the HI by a factor of 2.

  14. Long-term time series prediction using OP-ELM.

    Science.gov (United States)

    Grigorievskiy, Alexander; Miche, Yoan; Ventelä, Anne-Mari; Séverin, Eric; Lendasse, Amaury

    2014-03-01

    In this paper, an Optimally Pruned Extreme Learning Machine (OP-ELM) is applied to the problem of long-term time series prediction. Three known strategies for the long-term time series prediction i.e. Recursive, Direct and DirRec are considered in combination with OP-ELM and compared with a baseline linear least squares model and Least-Squares Support Vector Machines (LS-SVM). Among these three strategies DirRec is the most time consuming and its usage with nonlinear models like LS-SVM, where several hyperparameters need to be adjusted, leads to relatively heavy computations. It is shown that OP-ELM, being also a nonlinear model, allows reasonable computational time for the DirRec strategy. In all our experiments, except one, OP-ELM with DirRec strategy outperforms the linear model with any strategy. In contrast to the proposed algorithm, LS-SVM behaves unstably without variable selection. It is also shown that there is no superior strategy for OP-ELM: any of three can be the best. In addition, the prediction accuracy of an ensemble of OP-ELM is studied and it is shown that averaging predictions of the ensemble can improve the accuracy (Mean Square Error) dramatically. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Schadelijke effecten van Dieldrin op voortplanting en nageslacht, anders dan via de inwerking op het erfelijk materiaal : een literatuurstudie

    NARCIS (Netherlands)

    Koëter, H.B.W.M.; Dreef-van der Meulen, H.C.; Stijkel, A.; Zielhuis, R.L.

    1989-01-01

    Literatuuronderzoek naar de schadelijke effecten van Dieldrin op voortplanting en nageslacht. Dierproefgegevens en humane gegevens worden geevalueerd. Aandacht wordt besteed aan blootstelling, effecten t.a.v. zwangerschap en nageslacht, effecten t.a.v. de geslachtsorganen, endocrien systeem en

  16. Groepsrisico op de kaart gezet. Toelichtend rapport

    NARCIS (Netherlands)

    Wiersma T; Vliet AAC van; Gooijer L; Boot H; TNO Bouw en Ondergrond; CEV

    2007-01-01

    In collaboration with TNO, RIVM has elaborated two methods aimed at providing improved insight into the risk of a large number of individuals (societal risk) being involved in an accident in a certain area. The basic principle of these methods is the so-called area-specific approach in which

  17. Groepsrisico op de kaart gezet. Hoofdrapport

    NARCIS (Netherlands)

    Wiersma T; Gooijer L; Vliet AAC van; Boot H; TNO Bouw en Ondergrond; CEV

    2007-01-01

    In collaboration with TNO, RIVM has elaborated two methods aimed at providing improved insight into the risk of a large number of individuals (societal risk) being involved in an accident in a certain area. The basic principle of these methods is the so-called area-specific approach in which

  18. Complexity and demographic explanations of cumulative culture.

    Directory of Open Access Journals (Sweden)

    Adrien Querbes

    Full Text Available Formal models have linked prehistoric and historical instances of technological change (e.g., the Upper Paleolithic transition, cultural loss in Holocene Tasmania, scientific progress since the late nineteenth century to demographic change. According to these models, cumulation of technological complexity is inhibited by decreasing--while favoured by increasing--population levels. Here we show that these findings are contingent on how complexity is defined: demography plays a much more limited role in sustaining cumulative culture in case formal models deploy Herbert Simon's definition of complexity rather than the particular definitions of complexity hitherto assumed. Given that currently available empirical evidence doesn't afford discriminating proper from improper definitions of complexity, our robustness analyses put into question the force of recent demographic explanations of particular episodes of cultural change.

  19. Avoiding Program-Induced Cumulative Overload (PICO).

    Science.gov (United States)

    Orr, Robin; Knapik, Joseph J; Pope, Rodney

    2016-01-01

    This article defines the concept of program-induced cumulative overload (PICO), provides examples, and advises ways to mitigate the adverse effects. PICO is the excessive cumulative physical workload that can be imparted to military personnel by a military training program with an embedded physical training component. PICO can be acute (accumulating within a single day) or chronic (accumulating across the entirety of the program) and results in adverse outcomes for affected personnel, including detrimental fatigue, performance degradation, injuries, or illness. Strategies to mitigate PICO include focusing administration and logistic practices during the development and ongoing management of a trainee program and implementing known musculoskeletal injury prevention strategies. More training is not always better, and trainers need to consider the total amount of physical activity that military personnel experience across both operational training and physical training if PICO is to be mitigated.

  20. Sharing a quota on cumulative carbon emissions

    Science.gov (United States)

    Raupach, Michael R.; Davis, Steven J.; Peters, Glen P.; Andrew, Robbie M.; Canadell, Josep G.; Ciais, Philippe; Friedlingstein, Pierre; Jotzo, Frank; van Vuuren, Detlef P.; Le Quéré, Corinne

    2014-10-01

    Any limit on future global warming is associated with a quota on cumulative global CO2 emissions. We translate this global carbon quota to regional and national scales, on a spectrum of sharing principles that extends from continuation of the present distribution of emissions to an equal per-capita distribution of cumulative emissions. A blend of these endpoints emerges as the most viable option. For a carbon quota consistent with a 2 °C warming limit (relative to pre-industrial levels), the necessary long-term mitigation rates are very challenging (typically over 5% per year), both because of strong limits on future emissions from the global carbon quota and also the likely short-term persistence in emissions growth in many regions.

  1. Structural Vibration Monitoring Using Cumulative Spectral Analysis

    Directory of Open Access Journals (Sweden)

    Satoru Goto

    2013-01-01

    Full Text Available This paper describes a resonance decay estimation for structural health monitoring in the presence of nonstationary vibrations. In structural health monitoring, the structure's frequency response and resonant decay characteristics are very important for understanding how the structure changes. Cumulative spectral analysis (CSA estimates the frequency decay by using the impulse response. However, measuring the impulse response of buildings is impractical due to the need to shake the building itself. In a previous study, we reported on system damping monitoring using cumulative harmonic analysis (CHA, which is based on CSA. The current study describes scale model experiments on estimating the hidden resonance decay under non-stationary noise conditions by using CSA for structural condition monitoring.

  2. Cumulative carbon emissions and the Green Paradox

    OpenAIRE

    Ploeg, Frederick Van der

    2013-01-01

    The green paradox states that a gradually more ambitious climate policy such as a renewables subsidy or an anticipated carbon tax induces fossil fuel owners to extract more rapidly and accelerate global warming. However, if extraction becomes more costly as reserves are depleted, such policies also shorten the fossil fuel era, induce more fossil fuel to be left in the earth, and thus curb cumulative carbon emissions. These consequences are relevant, as global warming depends primarily on cumu...

  3. Stenhammer, Wilhelm. sinfonien Nr. 1 F-Dur und Nr. 2 g-Moll op. 34, Excelsior! op. 13, Serenade F-Dur op. 31. Sinfonieorchester Göteborg, Neeme Järvi / Andreas K. W. Meyer

    Index Scriptorium Estoniae

    Meyer, Andreas K. W.

    1995-01-01

    Uuest heliplaadist "Stenhammer, Wilhelm. sinfonien Nr. 1 F-Dur und Nr. 2 g-Moll op. 34, Excelsior! op. 13, Serenade F-Dur op. 31. Sinfonieorchester Göteborg, Neeme Järvi". DG 2 CD 445857-2 (WD: 138'37")

  4. Stenhammer, Wilhelm. sinfonien Nr. 1 F-Dur und Nr. 2 g-Moll op. 34, Excelsior! op. 13, Serenade F-Dur op. 31. Sinfonieorchester Göteborg, Neeme Järvi / Andreas K. W. Meyer

    Index Scriptorium Estoniae

    Meyer, Andreas K. W.

    1995-01-01

    Uuest heliplaadist "Stenhammer, Wilhelm. sinfonien Nr. 1 F-Dur und Nr. 2 g-Moll op. 34, Excelsior! op. 13, Serenade F-Dur op. 31. Sinfonieorchester Göteborg, Neeme Järvi". DG 2 CD 445857-2 (WD: 138'37")

  5. Expansive Soil Crack Depth under Cumulative Damage

    Directory of Open Access Journals (Sweden)

    Bei-xiao Shi

    2014-01-01

    Full Text Available The crack developing depth is a key problem to slope stability of the expansive soil and its project governance and the crack appears under the roles of dry-wet cycle and gradually develops. It is believed from the analysis that, because of its own cohesion, the expansive soil will have a certain amount of deformation under pulling stress but without cracks. The soil body will crack only when the deformation exceeds the ultimate tensile strain that causes cracks. And it is also believed that, due to the combined effect of various environmental factors, particularly changes of the internal water content, the inherent basic physical properties of expansive soil are weakened, and irreversible cumulative damages are eventually formed, resulting in the development of expansive soil cracks in depth. Starting from the perspective of volumetric strain that is caused by water loss, considering the influences of water loss rate and dry-wet cycle on crack developing depth, the crack developing depth calculation model which considers the water loss rate and the cumulative damages is established. Both the proposal of water loss rate and the application of cumulative damage theory to the expansive soil crack development problems try to avoid difficulties in matrix suction measurement, which will surely play a good role in promoting and improving the research of unsaturated expansive soil.

  6. Breder screenen op hemoglobinopathie: niet alleen na de geboorte testen op HbP, maar ook daarvóór.

    NARCIS (Netherlands)

    Cornel, M.C.; Detmar, S.; Plass, A.M.C.; Moerman, D.; Waarlo, A.J.; Kinderen, M. de; Giordano, P.C.

    2009-01-01

    Vrijwel overal ter wereld wordt dragerschapsscreening op hemoglobinopathie aanbevolen tijdens of voorafgaand aan de zwangerschap met het oog op reproductieve keuzes. In Nederland wordt sinds 2007 sikkelcelziekte neonataal opgespoord ter preventie van complicaties bij het kind (hielprik). Ook dragers

  7. Cumulative Incidence of Cancer among People with AIDS in the United States

    Science.gov (United States)

    Simard, Edgar P.; Pfeiffer, Ruth M.; Engels, Eric A.

    2010-01-01

    BACKGROUND As people with acquired immunodeficiency syndrome (AIDS) live longer due to highly active antiretroviral therapy (HAART, widely available since 1996), the overall burden of cancer may increase. METHODS A population-based record linkage study identified cancers in 472,378 people with AIDS (1980–2006). Using non-parametric competing risk methods, we estimated cumulative incidence of cancer across 3 calendar periods (AIDS onset in 1980–1989, 1990–1995, and 1996–2006). RESULTS Measured at 5-years after AIDS onset, cumulative incidence of AIDS-defining cancer (ADC) declined sharply across AIDS calendar periods (from 18% in 1980–1989, to 11% in 1990–1995, to 4.2% in 1996–2006 [i.e., HAART era]). Cumulative incidence of Kaposi sarcoma declined from 14.3% during 1980–1989 to 6.7% during 1990–1995 to 1.8% during 1996–2006. Non-Hodgkin lymphoma (NHL) cumulative incidence declined from 3.8% during 1990–1995 to 2.2% during 1996–2006; during the HAART era, NHL was the commonest (53%) ADC. Cumulative incidence of non-AIDS-defining cancer (NADC) increased from 1.1% to 1.5% with no change thereafter (1.0%, 1996–2006), in part due to declines in competing mortality. However, cumulative incidence increased steadily over time for specific NADCs (anal cancer, Hodgkin lymphoma, and liver cancer). Lung cancer cumulative incidence increased from 0.14% during 1980–1989 to 0.32% during 1990–1995, with no change thereafter. CONCLUSIONS We noted dramatically declining cumulative incidence of 2 major ADCs (Kaposi sarcoma and NHL) and increases in some NADCs (specifically cancers of the anus, liver, and lung, and Hodgkin lymphoma). As HIV/AIDS is increasingly managed as a chronic disease, greater attention should be focused on cancer screening and prevention. PMID:20960504

  8. OP449 inhibits breast cancer growth without adverse metabolic effects.

    Science.gov (United States)

    Shlomai, Gadi; Zelenko, Zara; Antoniou, Irini Markella; Stasinopoulos, Marilyn; Tobin-Hess, Aviva; Vitek, Michael P; LeRoith, Derek; Gallagher, Emily Jane

    2017-10-01

    Hyperinsulinemia is associated with a decrease in breast cancer recurrence-free survival and overall survival. Inhibition of insulin receptor signaling is associated with glycemic dysregulation. SET is a direct modulator of PP2A, which negatively regulates the PI3K/AKT/mTOR pathway. OP449, a SET inhibitor, decreases AKT/mTOR activation. The effects of OP449 treatment on breast cancer growth in the setting of pre-diabetes, and its metabolic implications are currently unknown. We found that the volumes and weights of human MDA-MB-231 breast cancer xenografts were greater in hyperinsulinemic mice compared with controls (P < 0.05), and IR phosphorylation was 4.5-fold higher in these mice (P < 0.05). Human and murine breast cancer tumors treated with OP449 were 47% and 39% smaller than controls (P < 0.05, for both, respectively). AKT and S6RP phosphorylation were 82% and 34% lower in OP449-treated tumors compared with controls (P < 0.05, P = 0.06, respectively). AKT and S6RP phosphorylation in response to insulin was 30% and 12% lower in cells, pre-treated with OP449, compared with control cells (P < 0.01, P < 0.05, respectively). However, even with decreased AKT/mTOR activation, body weights and composition, blood glucose and plasma insulin, glucose tolerance, serum triglyceride and cholesterol levels were similar between OP449-treated mice and controls. Xenografts and liver tissue from OP449-treated mice showed a 64% and 70% reduction in STAT5 activation, compared with controls (P < 0.01 and P = 0.06, respectively). Our data support an anti-neoplastic effect of OP449 on human breast cancer cells in vitro and in xenografts in the setting of hyperinsulinemia. OP449 led to the inhibition of AKT/mTOR signaling, albeit, not leading to metabolic derangements. © 2017 Society for Endocrinology.

  9. Recursive Numerical Evaluation of the Cumulative Bivariate Normal Distribution

    CERN Document Server

    Meyer, Christian

    2010-01-01

    We propose an algorithm for evaluation of the cumulative bivariate normal distribution, building upon Marsaglia's ideas for evaluation of the cumulative univariate normal distribution. The algorithm is mathematically transparent, delivers competitive performance and can easily be extended to arbitrary precision.

  10. Climate mitigation: sustainable preferences and cumulative carbon

    Science.gov (United States)

    Buckle, Simon

    2010-05-01

    We develop a stylized AK growth model with both climate damages to ecosystem goods and services and sustainable preferences that allow trade-offs between present discounted utility and long-run climate damages. The simplicity of the model permits analytical solutions. Concern for the long-term provides a strong driver for mitigation action. One plausible specification of sustainable preferences leads to the result that, for a range of initial parameter values, an optimizing agent would choose a level of cumulative carbon dioxide (CO2) emissions independent of initial production capital endowment and CO2 levels. There is no technological change so, for economies with sufficiently high initial capital and CO2 endowments, optimal mitigation will lead to disinvestment. For lower values of initial capital and/or CO2 levels, positive investment can be optimal, but still within the same overall level of cumulative emissions. One striking aspect of the model is the complexity of possible outcomes, in addition to these optimal solutions. We also identify a resource constrained region and several regions where climate damages exceed resources available for consumption. Other specifications of sustainable preferences are discussed, as is the case of a hard constraint on long-run damages. Scientists are currently highlighting the potential importance of the cumulative carbon emissions concept as a robust yet flexible target for climate policymakers. This paper shows that it also has an ethical interpretation: it embodies an implicit trade off in global welfare between present discounted welfare and long-term climate damages. We hope that further development of the ideas presented here might contribute to the research and policy debate on the critical areas of intra- and intergenerational welfare.

  11. Long and Short Term Cumulative Structural Priming Effects

    OpenAIRE

    Kaschak, Michael P.; Kutta, Timothy J.; Coyle, Jacqueline M.

    2012-01-01

    We present six experiments that examine cumulative structural priming effects (i.e., structural priming effects that accumulate across many utterances). Of particular interest is whether (1) cumulative priming effects transfer across language production tasks and (2) the transfer of cumulative priming effects across tasks persists over the course of a week. Our data suggest that cumulative structural priming effects do transfer across language production tasks (e.g., from written stem complet...

  12. Preserved cumulative semantic interference despite amnesia

    Directory of Open Access Journals (Sweden)

    Gary Michael Oppenheim

    2015-05-01

    As predicted by Oppenheim et al’s (2010 implicit incremental learning account, WRP’s BCN RTs demonstrated strong (and significant repetition priming and semantic blocking effects (Figure 1. Similar to typical results from neurally intact undergraduates, WRP took longer to name pictures presented in semantically homogeneous blocks than in heterogeneous blocks, an effect that increased with each cycle. This result challenges accounts that ascribe cumulative semantic interference in this task to explicit memory mechanisms, instead suggesting that the effect has the sort of implicit learning bases that are typically spared in hippocampal amnesia.

  13. Cumulant matching for independent source extraction.

    Science.gov (United States)

    Phlypo, Ronald; Zarzoso, Vicente; Comon, Pierre; Lemahieu, Ignace

    2008-01-01

    In this work we show how one can make use of priors on signal statistics under the form of cumulant guesses to extract an independent source from an observed mixture. The advantage of using statistical priors on the signal lies in the fact that no specific knowledge is needed about its temporal behavior, neither about its spatial distribution. We show that these statistics can be obtained either by reasoning on the theoretical values of a supposed waveform, either by using a subset of the observations from which we know that their statistics are merely hindered by interferences. Results on an electro-cardiographic recording confirm the above assumptions.

  14. A Missing Link in the Evolution of the Cumulative Recorder

    Science.gov (United States)

    Asano, Toshio; Lattal, Kennon A.

    2012-01-01

    A recently recovered cumulative recorder provides a missing link in the evolution of the cumulative recorder from a modified kymograph to a reliably operating, scientifically and commercially successful instrument. The recorder, the only physical evidence of such an early precommercial cumulative recorder yet found, was sent to Keio University in…

  15. Original and cumulative prospect theory: a discussion of empirical differences

    NARCIS (Netherlands)

    P.P. Wakker; H. Fennema

    1997-01-01

    This note discusses differences between prospect theory and cumulative prospect theory. It shows that cumulative prospect theory is not merely a formal correction of some theoretical problems in prospect theory, but it also gives different predictions. Experiments are described that favor cumulative

  16. A model of cooperation: the Pact op Zuid information system

    Directory of Open Access Journals (Sweden)

    Frans Spierings

    2010-06-01

    Welzijnsorganisaties, onderzoekinstellingen, overheidsinstellingen en woningcorporaties zijn alle potentiële partners in stedelijke herstructureringsprogramma’s. Het combineren van de belangen van deze organisaties vormt een interessante managementuitdaging. Ook is het een uitdaging om een informatiesysteem te ontwikkelen dat tegemoet komt aan de informatiebehoefte van alle partners, zowel de afzonderlijke organisaties, als het collectief. Dit artikel zal deze uitdaging van informatiemanagement bespreken, door een case study naar cooperative knowledge production te presenteren. De case study heeft betrekking op het Rotterdamse stedelijk investeringssprogramma “Pact op Zuid”, een programma waarin tussen 2006 en 2016 1.5 miljard euro wordt geïnvesteerd in stedelijk gebied met 190.000 inwoners. Dit artikel geeft allereerst inzicht in literatuur over innovatieconfiguraties en lerende netwerken, concepten die belangrijk zijn om de complexiteit van stedelijke renovatie en cooperative knowledge production te begrijpen. Het bespreekt eveneens hoe cooperative knowledge production binnen Pact op Zuid plaatsvond.

  17. Cumulative versus end-of-course assessment : effects on self-study time and test performance

    NARCIS (Netherlands)

    Kerdijk, Wouter; Cohen-Schotanus, Janke; Mulder, B. Florentine; Muntinghe, Friso L. H.; Tio, Rene A.

    2015-01-01

    ContextStudents tend to postpone preparation for a test until the test is imminent, which raises various risks associated with cramming' behaviours, including that for suboptimal learning. Cumulative assessment utilises spaced testing to stimulate students to study more frequently and to prevent pro

  18. Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies.

    Science.gov (United States)

    Abidi, Maheen Z; Sohail, Muhammad R; Cummins, Nathan; Wilhelm, Mark; Wengenack, Nancy; Brumble, Lisa; Shah, Harshal; Jane Hata, Donna; McCullough, Ann; Wendel, Amy; Vikram, Holenarasipur R; Kusne, Shimon; Litzow, Mark; Letendre, Louis; Lahr, Brian D; Poeschla, Eric; Walker, Randall C

    2014-11-01

    As invasive mucormycosis (IM) numbers rise, clinicians suspect prior voriconazole worsens IM incidence and severity, and believe combination anti-fungal therapy improves IM survival. To compare the cumulative incidence (CI), severity and mortality of IM in eras immediately before and after the commercial availability of voriconazole all IM cases from 1995 to 2011 were analysed across four risk-groups (hematologic/oncologic malignancy (H/O), stem cell transplantation (SCT), solid organ transplantation (SOT) and other), and two eras, E1 (1995-2003) and E2, (2004-2011). Of 101 IM cases, (79 proven, 22 probable): 30 were in E1 (3.3/year) and 71 in E2 (8.9/year). Between eras, the proportion with H/O or SCT rose from 47% to 73%, while 'other' dropped from 33% to 11% (P = 0.036). Between eras, the CI of IM did not significantly increase in SCT (P = 0.27) or SOT (P = 0.30), and patterns of anatomic location (P = 0.122) and surgical debridement (P = 0.200) were similar. Significantly more patients received amphotericin-echinocandin combination therapy in E2 (31% vs. 5%, P = 0.01); however, 90-day survival did not improve (54% vs. 59%, P = 0.67). Since 2003, the rise of IM reflects increasing numbers at risk, not prior use of voriconazole. Frequent combination of anti-fungal therapy has not improved survival.

  19. Cumulative Environmental Management Association : Wood Buffalo Region

    Energy Technology Data Exchange (ETDEWEB)

    Friesen, B. [Syncrude Canada Ltd., Edmonton, AB (Canada)

    2001-07-01

    The recently announced oil sands development of the Wood Buffalo Region in Alberta was the focus of this power point presentation. Both mining and in situ development is expected to total $26 billion and 2.6 million barrels per day of bitumen production. This paper described the economic, social and environmental challenges facing the resource development of this region. In addition to the proposed oil sands projects, this region will accommodate the needs of conventional oil and gas production, forestry, building of pipelines and power lines, municipal development, recreation, tourism, mining exploration and open cast mining. The Cumulative Environmental Management Association (CEMA) was inaugurated as a non-profit association in April 2000, and includes 41 members from all sectors. Its major role is to ensure a sustainable ecosystem and to avoid any cumulative impacts on wildlife. Other work underway includes the study of soil and plant species diversity, and the effects of air emissions on human health, wildlife and vegetation. The bioaccumulation of heavy metals and their impacts on surface water and fish is also under consideration to ensure the quality and quantity of surface water and ground water. 3 figs.

  20. Cumulative environmental management and the oil sands

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    In response to concerns regarding the cumulative environmental impacts of oil sands development within the Athabasca oil sands deposit, the government of Alberta established a Regional Sustainable Development Strategy (RSDS) to balance development with environmental protection. The environmental issues identified through the RSDS were addressed by the Cumulative Environmental Management Association (CEMA). CEMA's boundary is the Wood Buffalo region of northeastern Alberta. It identifies existing and future environmental effects in the region and proposes recommendations to regulatory bodies for reducing environmental impacts associated with oil sands development. This presentation outlined some of the 55 stakeholder representatives of CEMA, including Alberta government departments associated with resource development, oil sand developers within the region, and Aboriginal communities and First Nations. These stakeholders provide input on sector priorities and agree on environmental thresholds. Established working groups also address technical and scientific research issues identified in the RSDS such as sustainable ecosystems; surface waters; trace metals and air contaminants; nitrogen oxides and sulphur dioxides; and land reclamation. To date, CEMA has submitted more than 50 reports and has made 4 major environmental recommendations for trace metal management, ecosystem management tools, a framework for acid deposition management, and a landscape design checklist. tabs., figs.

  1. Higher Order Cumulants in Colorless Partonic Plasma

    CERN Document Server

    Cherif, S; Ladrem, M

    2016-01-01

    Any physical system considered to study the QCD deconfinement phase transition certainly has a finite volume, so the finite size effects are inevitably present. This renders the location of the phase transition and the determination of its order as an extremely difficult task, even in the simplest known cases. In order to identify and locate the colorless QCD deconfinement transition point in finite volume $T_{0}(V)$, a new approach based on the finite-size cumulant expansion of the order parameter and the $\\mathscr{L}_{m,n}$-Method is used.We have shown that both cumulants of higher order and their ratios, associated to the thermodynamical fluctuations of the order parameter, in QCD deconfinement phase transition behave in a particular enough way revealing pronounced oscillations in the transition region. The sign structure and the oscillatory behavior of these in the vicinity of the deconfinement phase transition point might be a sensitive probe and may allow one to elucidate their relation to the QCD phase...

  2. Innovativeness, population size and cumulative cultural evolution.

    Science.gov (United States)

    Kobayashi, Yutaka; Aoki, Kenichi

    2012-08-01

    Henrich [Henrich, J., 2004. Demography and cultural evolution: how adaptive cultural processes can produce maladaptive losses-the Tasmanian case. Am. Antiquity 69, 197-214] proposed a model designed to show that larger population size facilitates cumulative cultural evolution toward higher skill levels. In this model, each newborn attempts to imitate the most highly skilled individual of the parental generation by directly-biased social learning, but the skill level he/she acquires deviates probabilistically from that of the exemplar (cultural parent). The probability that the skill level of the imitator exceeds that of the exemplar can be regarded as the innovation rate. After reformulating Henrich's model rigorously, we introduce an overlapping-generations analog based on the Moran model and derive an approximate formula for the expected change per generation of the highest skill level in the population. For large population size, our overlapping-generations model predicts a much larger effect of population size than Henrich's discrete-generations model. We then investigate by way of Monte Carlo simulations the case where each newborn chooses as his/her exemplar the most highly skilled individual from among a limited number of acquaintances. When the number of acquaintances is small relative to the population size, we find that a change in the innovation rate contributes more than a proportional change in population size to the cumulative cultural evolution of skill level.

  3. Residue levels and risk assessment of pesticides in nuts of China.

    Science.gov (United States)

    Liu, Yihua; Shen, Danyu; Li, Shiliang; Ni, Zhanglin; Ding, Ming; Ye, Caifen; Tang, Fubin

    2016-02-01

    The pesticide residue levels of three nuts (chestnut, walnut, pinenut) collected from seven main producing areas of China were investigated. Twenty-nine pesticides, including organophosphates (OPs), organochlorines (OCs), pyrethroids (PYs) and two fungicides (triadimefon and buprofezin) were analyzed by gas chromatography (GC). Four OPs (acephate, dimethoate, chlorpyrifos and parathion-methyl) were found in 11.4% samples, with the concentrations of 19.0 µg kg(-1) to 74.0 µg kg(-1). Six OCs (DDT, HCH, endosulfan, quintozene, aldrin and dieldrin) were found in 18.2% samples, with the concentrations of 2.0 µg kg(-1) to 65.7 µg kg(-1). Among OCs, p,p-DDE and α-HCH were the dominant isomer for DDT and HCH. Five PYs (fenpropathrin, fenvalerate, cypermethrin, bifenthrin and cyhalothrin) were found in 15.9% samples, with the concentrations of 2.5 µg kg(-1) to 433.0 µg kg(-1). Fenpropathrin was the most frequently detected pesticide. In addition, triadimefon and buprofezin were detected only in two samples. For the tested nuts, 25.0% samples with multiple residues (containing more than two pesticides) were noted, even up to 9.1% samples with five pesticide residues. The residue of 15.9% samples was higher than the maximum residue limits (MRLs) of China. The short-term risks for the tested nuts were below 1.2%, and the highest long-term risk was 12.58%. The cumulative risk (cHI) for the tested pesticides were 8.43% (OPs), 0.42% (OCs), 12.82% (PYs) and 0.15% (fungicides), respectively. The total cHI was 21.82%. There was no significant health risk for consumers via nuts consumption.

  4. Ion cumulation by conical cathode electrolysis.

    CERN Document Server

    Grishin, V G

    2002-01-01

    Results of solid-state sodium stearate electrolysis with conical and cylindrical cathodes is presented here. Both electric measurement and conical samples destruction can be explained if a stress developing inside the conical sample is much bigger than in the cylindrical case and there is its unlimited amplification along cone slopes. OTHER KEYWORDS: ion, current, solid, symmetry, cumulation, polarization, depolarization, ionic conductor,superionic conductor, ice, crystal, strain, V-center, V-centre, doped crystal, interstitial impurity, intrinsic color center, high pressure technology, Bridgman, anvil, experiment, crowdion, dielectric, proton, layer, defect, lattice, dynamics, electromigration, mobility, muon catalysis, concentration, doping, dopant, conductivity, pycnonuclear reaction, permittivity, dielectric constant, point defects, interstitials, polarizability, imperfection, defect centers, glass, epitaxy, sodium hydroxide, metallic substrate, crystallization, point, tip, susceptibility, ferroelectric, ...

  5. [Cumulative trauma disorders: work or professional disease?].

    Science.gov (United States)

    de Carvalho, Marcus Vitor Diniz; Cavalcanti, Francisco Ivo Dantas; Soriano, Evelyne Pessoa; de Miranda, Hênio Ferreira

    2009-06-01

    This study aimed at reviewing the Brazilian legislation applied to occupational health. It refers to the diseases embodied in the Repetition Strain Injury (RSI) and Cumulative Trauma Disorders (CTD) regarded as work or professional diseases. This analysis allowed to perform the historical evolution of legislation concerning the issue, noting that the state of the art of regulation on RSI-CTD is anchored in specific regulation present in the Normative Instruction 98/2003, that establishes the diagnostic criteria and classification of RSI-CTD. It was concluded that according to the existing legislation in Brazil, the pathologies related to RSI-CTD are considered as work diseases and their legal effects are similar to the work-related accidents.

  6. Telen en vermarkten van nieuwe vollegrondsgroenten op praktijkbedrijven

    NARCIS (Netherlands)

    Wijk, van C.A.P.

    2010-01-01

    In het project 'Telen en vermarkten van nieuwe vollegrondsgroenten op praktijkbedrijven' zijn de afgelopen jaren een aantal nieuwe gewassen in demo getoetst. Dat zijn midi courgette, sugar snap voor verse markt en verwerking, romaanse sla, nieuwe pompoensoorten, rode spitskool en de radicchio trevis

  7. Het effect van huisvesting op het welzijn van paarden

    NARCIS (Netherlands)

    Visser, E.K.

    2007-01-01

    Enkele decennia geleden werd de kennis van paarden nog automatisch overgedragen van vader op zoon, omdat veel families dagelijks met paarden werkten. Eén van de gevolgen van een veranderende manier van houden van en omgaan met paarden is het ontstaan van stress en frustratie. Een aanzienlijk deel va

  8. TNT gaat op klantreis om tevredenheid te meten

    NARCIS (Netherlands)

    Jorritsma, A.

    2010-01-01

    Als we weten wat klanten ervaren en voelen, weten we ook wat we goed doen en waar de verbeterpunten zitten, hoe we de omzet kunnen laten groeien en kosten kunnen besparen. TNT Post omarmde de door TNO ontwikkelde 'Customer Journey' methode en ging op klantreis.

  9. Biesbosch: microverontreinigingen met macro-effecten op kleine zoogdieren?

    NARCIS (Netherlands)

    Brink, van den N.W.; Bosveld, A.T.C.; Bie, de P.A.F.; Jong, de J.

    2000-01-01

    Plannen om een deel van de Biesbosch opnieuw in te richten kunnen effecten hebben voor sedimentatie-processen. Om inzicht te krijgen in de risico's van dit soort ingrepen is Alterra een onderzoek gestart naar effecten van verontreiniging op kleine zoogdieren in de Biesbosch

  10. Variatie in vee : biodiversiteit op de boerderij bedreigd

    NARCIS (Netherlands)

    Zegwaard, A.; Buiter, R.; Oldenbroek, J.K.; Everdingen, J.

    2010-01-01

    Op de boerderij wordt de diversiteit van het leven bedreigd. Steeds minder dieren krijgen steeds meer nakomelingen. Een gebrek aan genetische variatie in het gevolg. Door inteelt kunnen gezondheidsproblemen ontstaan, en ongemerkt kunnen bepaalde eigenschappen verdwijnen. Ook de variatie in ons lands

  11. Op een kaal plein valt niets te kiezen (Interview)

    NARCIS (Netherlands)

    Boo, de M.; Lenzholzer, S.

    2010-01-01

    Pleinen en straten worden geteisterd door gure windvlagen of je smelt juist weg als de zon flink schijnt. In haar proefschrift legt Sanda Lenzholzer uit dat ontwerpers meer rekening moeten houden met het microklimaat in de stad. Dat houdt ook de aso’s op afstand.

  12. Toepassing van de basisvrachtbenadering op fosfaat van compost; advies

    NARCIS (Netherlands)

    Ehlert, P.A.I.

    2005-01-01

    Bij het vormgeven van het stelsel van gebruiksnormen is een maatschappelijke discussie ontstaan over de aanvoer van fosfaat met grond in compost en zwarte grond. Deze deskstudie gaat in op vragen die hierbij gesteld zijn. Het aandeel grond in compost en zwarte grond en de hoeveelheid fosfaat daarin

  13. Microscopisch onderzoek van enkele op verschillende wijzen behandelde sperciebonen

    NARCIS (Netherlands)

    Pinckaers, V.G.Z.; Jong, de W.J.H.J.

    1980-01-01

    Door middel van microscopisch onderzoek werd nagegaan of er strukturele verschillen waar te nemen zijn tussen de op verschillende wijze voorbehandelde diepvries sperciebonen en verse sperciebonen. Aan de hand van coupes werd nagegaan of door het blancheerproces bij diepvriesgroenten verschillen in s

  14. Wankel succes met druppelfertigatie in Franse prei : Op Proefboerderij Vredepeel

    NARCIS (Netherlands)

    Verstegen, S.; PPO Akkerbouw, Groene Ruimte en Vollegrondsgroente

    2007-01-01

    Bij PPO Vredepeel wordt in proeven prei geteeld met behulp van druppelfertigatie, met minder kunstmest en minder uitspoeling als doelen. In Frankrijk werken al sinds 2005 vijf preitelers in de streek Loire-Atlantique er mee op hun hele areaal. Eén van hen gebruikt 20 tot 40 procent minder kunst mest

  15. Zetmeelaardappelteelt: op naar 20-15-10 : communicatieproject AVEBE 2012

    NARCIS (Netherlands)

    Wijnholds, K.H.

    2012-01-01

    De ontkoppeling van de zetmeelaardappelteelt in het kader van het Gemeenschappelijk Landbouwbeleid heeft grote gevolgen voor de concurrentiepositie van deze teelt binnen de rotatie op het Veenkoloniale bedrijf. De teler is niet meer verplicht om daadwerkelijk zetmeelaardappelen te telen om toch de

  16. Bonaire Natioanl Marine Park (BNMP) op weg naar werelderfgoed

    NARCIS (Netherlands)

    Cremer, J.S.M.; Meesters, H.W.G.

    2012-01-01

    Het Bonaire National Marine Park (BNMP) staat sinds 2011 op de Nederlandse Voorlopige lijst van het Werelderfgoed. Dit betekent dat een nominatie kan worden ingediend om als natuurlijk werelderfgoed erkend te worden. In dit rapport wordt beschreven welke stappen nodig zijn om tot een nominatie voor

  17. LHC: op zoek naar geheimen van de oersoep

    NARCIS (Netherlands)

    Mischke, A.

    2010-01-01

    De krachtigste deeltjesversneller ter wereld, de LHC bij Genève, is, na een jaar oponthoud, klaar voor zijn ontdekkingstocht. De Utrechtse natuurkundige André Mischke gaat met zijn onderzoeksgroep op zoek naar een bizarre materietoestand die heerste vlak na de oerknal. De eerste resultaten laten nie

  18. De effecten van voeding op opvliegers en nachtelijk zweten

    NARCIS (Netherlands)

    Smeets, A.J.P.G.; Raaij, van J.M.A.; Vries, de J.H.M.

    2004-01-01

    Veel vrouwen (60-82%) hebben rond de menopauze last van opvliegers en nachtelijk zweten. Een reguliere therapie tegen deze symptomen is hormoonsuppletie. Hoewel de beschikbare middelen effectief zijn, is er een terughoudend voorschrijfbeleid vanwege de verhoogde kans op borstkanker. Als alternatieve

  19. Realisatie van mestvergisting op De Marke : onderzoek en demonstratie

    NARCIS (Netherlands)

    Kool, A.; Hilhorst, G.J.; Vegte, van der D.Z.

    2005-01-01

    Op De Marke doen CLM en het Praktijkonderzoek ASG sinds enige jaren onderzoek naar de perspectieven van mestvergisting. Ze onderzoeken rentabiliteit, vermindering van de emissie van broeikasgassen en de mogelijkheden voor co-vergisting. Dit rapport beschrijft de ervaringen van de eerste jaren onderz

  20. Onderzoek naar invloed van lichtschema op titers bij vleeskuikens

    NARCIS (Netherlands)

    Middelkoop, van J.H.; Harn, van J.; Voorst, van S.

    1998-01-01

    Het is bekend dat het toepassen van een lichtschema van invloed is op de uitval als gevolg van infectieziektes. Dit was aanleiding voor het PP om onderzoek te doen naar de antilichaamtiters tegen NCD, IB en Gumboro bij vleeskuikens die bij verschillende lichtschema's gehouden werden.

  1. Richt wildbeheer op waar het om gaat (Opinie)

    NARCIS (Netherlands)

    Plaa, de A.; Boonman-Berson, S.H.

    2012-01-01

    Het afschieten van grote aantallen wilde zwijnen en edelherten stuit op steeds grotere weerstand. Ook groeit de twijfel of de huidige manier van jagen het aantal dieren wel in toom houdt. Kan het anders? Volgens Anouk de Plaa (provincie Gelderland) en Susan Boonman - Berson (Wageningen Universiteit)

  2. Op zoek naar de heilige graal van katalysatorprojecten in stadsontwikkeling

    NARCIS (Netherlands)

    Verheul, W.J.

    2013-01-01

    Iconische bouwwerken brengen de stad in beweging. Beroemde voorbeelden zijn het Guggenheim Museum Bilbao of het Sydney Opera House. Stadsbestuurders, ontwikkelaars en ontwerpers hopen doorgaans dat hun vastgoedproject een aanjagende werking heeft op de ontwikkeling van de buurt of de stad als geheel

  3. De invloed van werkeisen en hulpbronnen op uitputting en bevlogenheid

    NARCIS (Netherlands)

    Ruysseveldt, J. van; Smulders, P.; Taverniers, J.

    2008-01-01

    De kosten van psychosociale arbeidsbelasting in Nederland worden op 4 miljard euro per jaar geschat. Een goed inzicht in de werkkenmerken die uitputting en bevlogenheid (en daarmee samenhangend arbeidsongeschiktheid, ziekteverzuim en personeelsverloop) beïnvloeden is daardoor relevant. In dit

  4. Op naar meerwaarde! eHealth-monitor 2014.

    NARCIS (Netherlands)

    Krijgsman, J.; Peeters, J.; Burghouts, A.; Brabers, A.; Jong, J. de; Beenkens, F.; Friele, R.; Gennip, L. van

    2014-01-01

    Nederlandse patiënten zijn in vergelijking met vorig jaar beter op de hoogte van het bestaan van eHealth-mogelijkheden bij hun zorgverleners. Voorbeelden zijn online herhaalrecepten aanvragen of vragen stellen aan de dokter via e-mail. Nederlandse artsen maken in vergelijking met vorig jaar nog meer

  5. Voldoende greep op veiligheid? Benchmartk veiligheidscultuur in de Rijnmondregio

    NARCIS (Netherlands)

    Zwetsloot, G.I.J.M.; Bezemer, R.A.

    2013-01-01

    Bedrijven en overheidsinstanties hebben soms moeite met het identificeren van chronische veiligheidsissues. Op verzoek van DCMR bracht TNO de veiligheidscultuur in kaarr bij veertien BRZO-plichtige bedrijven in de Rijnmondregio. Conclusie: er is ruimte voor verbetering in bijna alle ond erzochte dim

  6. ProOpDB: Prokaryotic Operon DataBase.

    Science.gov (United States)

    Taboada, Blanca; Ciria, Ricardo; Martinez-Guerrero, Cristian E; Merino, Enrique

    2012-01-01

    The Prokaryotic Operon DataBase (ProOpDB, http://operons.ibt.unam.mx/OperonPredictor) constitutes one of the most precise and complete repositories of operon predictions now available. Using our novel and highly accurate operon identification algorithm, we have predicted the operon structures of more than 1200 prokaryotic genomes. ProOpDB offers diverse alternatives by which a set of operon predictions can be retrieved including: (i) organism name, (ii) metabolic pathways, as defined by the KEGG database, (iii) gene orthology, as defined by the COG database, (iv) conserved protein domains, as defined by the Pfam database, (v) reference gene and (vi) reference operon, among others. In order to limit the operon output to non-redundant organisms, ProOpDB offers an efficient method to select the most representative organisms based on a precompiled phylogenetic distances matrix. In addition, the ProOpDB operon predictions are used directly as the input data of our Gene Context Tool to visualize their genomic context and retrieve the sequence of their corresponding 5' regulatory regions, as well as the nucleotide or amino acid sequences of their genes.

  7. De invloed van watervogels op de bacteriologische zwemwaterkwaliteit

    NARCIS (Netherlands)

    Lange, de H.J.; Lammertsma, D.R.; Keizer-Vlek, H.E.

    2013-01-01

    Dit rapport beschrijft de invloed van watervogels op de bacteriologische zwemwaterkwaliteit van 20 zwemplassen. Hiervoor is in de 20 zwemplassen veldonderzoek verricht naar relaties tussen aantallen en soorten watervogels, waterplanten, helderheid en concentraties fecale bacteriën. De concentratie z

  8. Sibelius: Kullervo, Op. 7. Eeva-Liisa Saarinen / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Sibelius: Kullervo, Op. 7. Eeva-Liisa Saarinen, Jorma Hynninen. Estonian State Academic Male Choir, Helsinki University Male Choir, Helsinki Philharmonic Orchestra / Paavo Berglund. EMI Matrix CD CDM 565080-2 (72 minutes); Comparative versions: Mattila, Hynninen, Gothenburg SO / Järvi (1/87)(BIS)CD 313; Rorholm, Hynninen, Los Angeles PO / Salonen (7/93)(SONY)SK 52563

  9. Ik Kies Bewust; Effecten van het logo op het koopgedrag

    NARCIS (Netherlands)

    Kornelis, M.; Meeusen, M.J.G.

    2010-01-01

    Dit rapport beschrijft de effecten van het Ik Kies Bewust-logo in de markt. Daarbij wordt gekeken of en in welke mate de vraag naar de producten met het Ik Kies Bewust-logo groter wordt en welke effecten dit heeft op de vraag naar andere producten in diezelfde of andere productcategorieën.

  10. Onzekere effecten van foliumzuur op andere aandoeningen dan neuraalbuisdefecten

    NARCIS (Netherlands)

    Verhoef, P.; Katan, M.B.

    2006-01-01

    Suppletie met foliumzuur rondom de bevruchting reduceert de kans op het krijgen van een baby met een neuraalbuisdefect. 1 Observationele epidemiologische studies wekten hoop dat een hoge inname van foliumzuur via de voeding of supplement ook het risico van onder meer hart- en vaatziekten, kanker en

  11. Filipendula vulgaris Moench (Knolspirea) toch wild op de Veluwe

    NARCIS (Netherlands)

    Hertog, André

    1998-01-01

    Midden op het meest westelijk gelegen heideterrein van de Veluwe ligt, voor zover bekend, de enige groeiplaats van Knolspirea in Nederland. De bewuste plek ligt vlak bij een leemputje. Het overgrote deel van de populatie groeit in een kuiltje van ongeveer 30 cm diepte. Deze gaten zijn vrijwel zeker

  12. De invloed van bodemreiniging op de biologische beschikbaarheid van metalen

    NARCIS (Netherlands)

    Adema DMM*; Boer JLM de; Gestel CAM van; Jong P de*

    1987-01-01

    Er werd onderzoek uitgevoerd met als doel het uitlooggedrag en de biologische beschikbaarheid van metalen in verontreinigde gronden voor en na reiniging te bepalen. Dit (deel)rapport beschrijft de resultaten van het onderzoek naar de biologische beschikbaarheid. Op zes locaties in Nederland

  13. Vruchtensappen kunnen fruit niet vervangen : kritiek op claims rond sapproducten

    NARCIS (Netherlands)

    Hentzepeter, V.; Nieuw Amerongen, A.V.; Sluis, van der A.A.

    2005-01-01

    Vruchtensappen zijn minder gezond dan gedacht. Sommige producten bevatten minder voedingsstoffen dan ze beloven, zijn slecht voor het gebit of zetten de consument met hun natuurlijke uitstraling op het verkeerde been. Vruchtensap is geen volwaardig alternatief voor vers fruit. Sommige sappen bevatte

  14. Sibelius: Kullervo, Op. 7. Eeva-Liisa Saarinen / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Sibelius: Kullervo, Op. 7. Eeva-Liisa Saarinen, Jorma Hynninen. Estonian State Academic Male Choir, Helsinki University Male Choir, Helsinki Philharmonic Orchestra / Paavo Berglund. EMI Matrix CD CDM 565080-2 (72 minutes); Comparative versions: Mattila, Hynninen, Gothenburg SO / Järvi (1/87)(BIS)CD 313; Rorholm, Hynninen, Los Angeles PO / Salonen (7/93)(SONY)SK 52563

  15. Engaging the public through writing an op-ed

    Science.gov (United States)

    Labosier, Chris; Zhu, Laiyin; Quiring, Steven

    2012-10-01

    In May, prior to the start of the 2012 hurricane season, AGU asked us to write an op-ed for the Houston Chronicle on the importance of funding hurricane research. We were excited to be asked and pleased that AGU facilitated the process by providing us with some guidance on writing the op-ed. Given the impact that Hurricane Ike had in Texas just a few years ago, we felt it was important to remind the citizens of the greater Houston metropolitan area of the societal benefits of funding hurricane research. Thanks to the assistance of AGU staff, writing the article required only a few hours of time. Our op-ed was published in the print edition of the Houston Chronicle on 1 June 2012, the official start of the hurricane season (http://www.chron.com/default/article/Tight-budgets-posing-threat-to-Texas-hurricane-3600363.php). It was picked up by the media relations office in the College of Geosciences at Texas A&M University and featured on the college's Web site in the dean's biweekly briefing and on its Facebook page. As a result, the op-ed reached a large and diverse audience.

  16. Ecologische en natuurbeschermingsrechtelijke aspecten van windturbines op land

    NARCIS (Netherlands)

    Winkelman, J.E.; Kistenkas, F.H.; Epe, M.J.

    2008-01-01

    Uit dit literatuuronderzoek komt naar voren dat windturbines aanzienlijke effecten kunnen hebben op vleermuizen en vogels in de zin van aantallen aanvaringsslachtoffers, mate van verstoring en/of barrièrewerking. Omdat vleermuizen en vogels onder andere bescherming genieten vanwege de Natuurbescherm

  17. Toepassing van de basisvrachtbenadering op fosfaat van compost; advies

    NARCIS (Netherlands)

    Ehlert, P.A.I.

    2005-01-01

    Bij het vormgeven van het stelsel van gebruiksnormen is een maatschappelijke discussie ontstaan over de aanvoer van fosfaat met grond in compost en zwarte grond. Deze deskstudie gaat in op vragen die hierbij gesteld zijn. Het aandeel grond in compost en zwarte grond en de hoeveelheid fosfaat daarin

  18. Sibelius: Scaramouche op. 71, Neeme Järvi / Rainer Wagner

    Index Scriptorium Estoniae

    Wagner, Rainer

    1991-01-01

    Uuest heliplaadist "Sibelius: Scaramouche op. 71 [World Premiere REcording of the Complete Score]. Hochzeitmarsch aus der Musik zum Drama Die Sprache der Vögel [Wedding March "The Language of the Birds"]. Göteborger Sinfoniker, Neeme Järvi. BIS/Disco-Ccenter CD 502 (WD:68'28") DDD

  19. Ik Kies Bewust; Effecten van het logo op het koopgedrag

    NARCIS (Netherlands)

    Kornelis, M.; Meeusen, M.J.G.

    2010-01-01

    Dit rapport beschrijft de effecten van het Ik Kies Bewust-logo in de markt. Daarbij wordt gekeken of en in welke mate de vraag naar de producten met het Ik Kies Bewust-logo groter wordt en welke effecten dit heeft op de vraag naar andere producten in diezelfde of andere productcategorieën.

  20. Volle bak op nuttige preidag : Landelijke preidag bij Proefboerderij Vredepeel

    NARCIS (Netherlands)

    Stallen, J.; PPO Akkerbouw, Groene Ruimte en Vollegrondsgroente

    2007-01-01

    Het was druk op de landelijk preidag 2007, bij PPO Vredepeel . Naast belangstelling uit Nederland ontbrak het ook niet aan buitenlandse interesse, met sectorgenoten uit België, Scandinavië, Frankrijk en Engeland. De meeste belangstelling van de aanwezigen ging uit naar de demonstratie van klembandro

  1. Besparen op arbeidskosten : mechanische snoei, ervaringen uit onderzoek en praktijk

    NARCIS (Netherlands)

    Steeg, van der P.A.H.; Buitenhuis, E.

    2012-01-01

    Mechanisatie van snoei, dunning en pluk is een mogelijkheid om te besparen op arbeidskosten. Daarmee verhoogt de rentabiliteit van de teelt. In Nederland passen diverse telers al jaren het systeem Le mur fruitier met mechanische snoei bij appel toe. PPO Randwijk en Erik Buitenhuis (EB Fruit Projects

  2. Sibelius: Scaramouche op. 71, Neeme Järvi / Rainer Wagner

    Index Scriptorium Estoniae

    Wagner, Rainer

    1991-01-01

    Uuest heliplaadist "Sibelius: Scaramouche op. 71 [World Premiere REcording of the Complete Score]. Hochzeitmarsch aus der Musik zum Drama Die Sprache der Vögel [Wedding March "The Language of the Birds"]. Göteborger Sinfoniker, Neeme Järvi. BIS/Disco-Ccenter CD 502 (WD:68'28") DDD

  3. Onderzoek naar invloed van lichtschema op titers bij vleeskuikens

    NARCIS (Netherlands)

    Middelkoop, van J.H.; Harn, van J.; Voorst, van S.

    1998-01-01

    Het is bekend dat het toepassen van een lichtschema van invloed is op de uitval als gevolg van infectieziektes. Dit was aanleiding voor het PP om onderzoek te doen naar de antilichaamtiters tegen NCD, IB en Gumboro bij vleeskuikens die bij verschillende lichtschema's gehouden werden.

  4. Effect van coronageluid op het gedrag van paarden

    NARCIS (Netherlands)

    Neijenhuis, F.; Wijhe-Kiezebrink, van M.C.; Plomp, M.; Visser, E.K.

    2016-01-01

    Het algemene beeld is dat de geïnterviewde paardenhouders denken dat de paarden in de weide of paddock niet reageren op het coronageluid. Een enkele paardenhouder geeft aan dat sommige paarden een korte gewenningsperiode nodig hebben in geval van coronageluid, zoals ook bij andere, nieuwe geluiden

  5. Belastbaarheid van de menselijke huid op druk- en schuifkrachten

    NARCIS (Netherlands)

    Danz, M.H.

    1985-01-01

    In deze skriptie worden resultaten uit de literatuur op het gebied van de mechanische belastbaarheid van de menselijke huid behandeld. Daarbij wordt alleen gekeken naar die belastinggevallen, waarvan verwacht kan worden dat ze bij het dragen van pro- en orthesen zullen voorkomen: drukkracht (eventue

  6. Op een kaal plein valt niets te kiezen (Interview)

    NARCIS (Netherlands)

    Boo, de M.; Lenzholzer, S.

    2010-01-01

    Pleinen en straten worden geteisterd door gure windvlagen of je smelt juist weg als de zon flink schijnt. In haar proefschrift legt Sanda Lenzholzer uit dat ontwerpers meer rekening moeten houden met het microklimaat in de stad. Dat houdt ook de aso’s op afstand.

  7. Teks op teks op teks: intertekstualiteit in Ingrid Winterbach se Niggie

    Directory of Open Access Journals (Sweden)

    M. Botha

    2006-07-01

    Full Text Available Text on text on text: intertextuality in Ingrid Winterbach’s Niggie This article focuses on the creative adaptation of Anglo-Boer War material in Ingrid Winterbach’s (formerly Lettie Viljoen “Niggie” (“Cousin” (2002 with specific reference to the historiographical-metafictional element and intertextual game with texts written during or shortly after the Anglo-Boer War in Dutch, such as Totius’ “Vier-en-sestig dae te velde: ’n oorlogsdagboek” (“Sixty four days afield: a war diary” (1977 and in English, “Woman’s endurance” (1904 by A.D.L. and Deneys Reitz’s “Commando: a Boer journal of the Boer War” (1932. The intertextuality of more recent texts such as “Op soek na generaal Mannetjies Mentz” (“In Search of General Mannetjies Mentz” (1998 by Christoffel Coetzee, Klaas Steytler’s “Ons oorlog” (“Our war” (2000 and Etienne Leroux’s “Magersfontein, O! Magersfontein” (1976 will also be discussed. A literary analysis is done of the novel “Niggie”, with specific focus on the nature and function of Anglo-Boer War material in Winterbach’s text. The question is posed why is there such a sustained focus and creative adaptation of Anglo-Boer War texts in Winterbach’s oeuvre, especially in “Belemmering” (“Impediment” (1990; “Karolina Ferreira” (1993; “Buller se plan” (“Buller’s plan” (1999 and “Niggie” (“Cousin” (2002? How does she adapt this material? What is the function of this process and in what way does this novel impact on the reader a century after the war?

  8. Mixing methodologies in ESL: Cumulative or contradictory?

    Directory of Open Access Journals (Sweden)

    Doug Absalom

    2013-02-01

    Full Text Available It is often assumed that an eclectic approach to teaching a second language is desirable, as no single method can be regarded as universally ideal. Such a mixed methodologies approach was adopted in an ESL course at the University of Newcastle in Australia, deliberately incorporating the use of CALL techniques to enhance the success of a variety of other methods. Surprisingly, students who reported to have enjoyed the CALL classes and testified to their practical usefulness fared worse in the examinations than students in the previous five years, when CALL techniques were not used The. writer speculates on the possible reasons for this unexpected finding, and cites a further example of the lack of success of a mixed methodologies approach. Dit word dikwe/s aangeneem dat 'n eklektiese benadering tot tweedetaalonde"ig wenslik is, aangesien dit aanvaar word dat geen onde"igmetode as universeel ideaal beskou kan word nie. Met die aanname in gedagte, is 'n gemengde metodologiese benadering gebruik vir die aanbieding van 'n Engels tweedetaalkursus aan die Universiteit van Newcastle in Australie. Die kursus het, bo en behalwe die gewone tweedetaalonde"igmetodes, ook gebruik gemaak van CALL-tegnieke (dw.s. rekenaar-ondersteunde leertegnieke met die bedoeling om die taalverwerwingsproses op die wyse te bevorder. Teen die verwagting in het studente wat aangedui het dat die rekenaarklasse genotvol en waardevol was, swakker in die eindeksamen gevaar as die gemiddelde student wat geen CALL-onderrig in dieseifde kursus oor die vorige vyf jaar ontvang het nie. Die skrywer spekuleer oor die moontlike redes vir hierdie onverwagte swak vertoning en ve~s na nog 'n voorbeeld van onsuksesvol/e resultate na die gebruik van 'n gemengde-metode-benadering.

  9. Vrede-, Bevrijding- en Vrijheid-verhalen op locatie – augmented reality en navigatie applicatie op smart phones

    NARCIS (Netherlands)

    Lammeren, van R.J.A.; Bergsma, A.R.; Franke, G.J.

    2010-01-01

    In de periode december 2009 - mei 2010 is de applicatie Vrede, Bevrijding en Vrijheid ontwikkeld. Deze applicatie biedt gebruikers van smart phones met draadloos internet, zoals Android-phones en iPhones, de mogelijkheid om op locatie verhalen te luisteren, te lezen en te bekijken. Dit verslag rappo

  10. Tchaikovsky: Piano Concerto N1 in B flat minor, Op.23 / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1990-01-01

    Uuest heliplaadist "Tchaikovsky: Piano Concerto N1 in B flat minor, Op.23, Suite N4 in G major, Op.61, "Mozartiana". Constantine Orbelian (pf), Philarmonia Orchestra, Neeme Järvi" Chandos ABTD 1413. CHAN 8777

  11. Ideaalbeeld freesia op de kop (interview met Frank van der Helm)

    NARCIS (Netherlands)

    Sleegers, J.; Helm, van der F.P.M.

    2012-01-01

    Een onderzoek naar bodemisolatie in freesia heeft niet het bedoelde effect opgeleverd. Maar het heeft wel het ideaalbeeld van de plant op zijn kop gezet. De schraalste planten leverden de mooiste takken op.

  12. Reger: Vier Tondichtungen nach Arnold Böcklin, Op. 128 / Michael Oliver

    Index Scriptorium Estoniae

    Oliver, Michael

    1990-01-01

    Uuest heliplaadist "Reger: Vier Tondichtungen nach Arnold Böcklin, Op. 128, Variations and Fugue on a Theme of J. A. Hiller, Op. 100. Royal Concertgebouw Orchestra, Neeme Järvi" Chandos ABRD 1426. ABTD 1426. CHAN 8794

  13. Reger: Vier Tondichtungen nach Arnold Böcklin, Op. 128 / Michael Oliver

    Index Scriptorium Estoniae

    Oliver, Michael

    1990-01-01

    Uuest heliplaadist "Reger: Vier Tondichtungen nach Arnold Böcklin, Op. 128, Variations and Fugue on a Theme of J. A. Hiller, Op. 100. Royal Concertgebouw Orchestra, Neeme Järvi" Chandos ABRD 1426. ABTD 1426. CHAN 8794

  14. Alfven. Symphony No 5 in A minor, Op. 54 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Alfven. Symphony No 5 in A minor, Op. 54. The Mountain King - Suite, Gustav II Adolf, Op. 49 - Elegy. Royal Stockholm Philarmonic Orchestra / Neeme Järvi. BIS CD 585 (68 minutes) Recorded in association with Trygg Hansa"

  15. Alfven. Symphony No 5 in A minor, Op. 54 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Alfven. Symphony No 5 in A minor, Op. 54. The Mountain King - Suite, Gustav II Adolf, Op. 49 - Elegy. Royal Stockholm Philarmonic Orchestra / Neeme Järvi. BIS CD 585 (68 minutes) Recorded in association with Trygg Hansa"

  16. Sibelius: Der Sturm, Op. 109, Neeme Järvi / Gerhard Pätzig

    Index Scriptorium Estoniae

    Pätzig, Gerhard

    1990-01-01

    Uuest heliplaadist "Sibelius: Der Sturm, Op. 109, (Vorspiel und Konzertsuiten zu Shakespeares Drama), Cassazione, Op.6, Preludio, Tiera. Sinfonieorchester Göteborg, Neeme Järvi". BIS/ Disco-Center CD 448 71'43") DDD

  17. Tchaikovsky: Symphony No. 5 in E minor, Op. 64 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Tchaikovsky: Symphony No. 5 in E minor, Op. 64; Rimsky-Korsakov: Russian Easter Festival Overture, Op. 36. Philharmonia Orchestra / Giuseppe Sinopoli; Overture - selected comparison: Gothenburg SO, Järvi (3/91) DG 429984-2GH

  18. Tchaikovsky: Symphony No. 5 in E minor, Op. 64 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Tchaikovsky: Symphony No. 5 in E minor, Op. 64; Rimsky-Korsakov: Russian Easter Festival Overture, Op. 36. Philharmonia Orchestra / Giuseppe Sinopoli; Overture - selected comparison: Gothenburg SO, Järvi (3/91) DG 429984-2GH

  19. Tchaikovsky: Piano Concerto N1 in B flat minor, Op.23 / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1990-01-01

    Uuest heliplaadist "Tchaikovsky: Piano Concerto N1 in B flat minor, Op.23, Suite N4 in G major, Op.61, "Mozartiana". Constantine Orbelian (pf), Philarmonia Orchestra, Neeme Järvi" Chandos ABTD 1413. CHAN 8777

  20. Sibelius: Der Sturm, Op. 109, Neeme Järvi / Gerhard Pätzig

    Index Scriptorium Estoniae

    Pätzig, Gerhard

    1990-01-01

    Uuest heliplaadist "Sibelius: Der Sturm, Op. 109, (Vorspiel und Konzertsuiten zu Shakespeares Drama), Cassazione, Op.6, Preludio, Tiera. Sinfonieorchester Göteborg, Neeme Järvi". BIS/ Disco-Center CD 448 71'43") DDD

  1. Landelijk Meetnet Bodemkwaliteit: Nematodenfauna. Deel 6: Bemonstering 1996 en 1997 (melkveehouderijbedrijven op rivierklei, zeeklei en tuinbouw)

    NARCIS (Netherlands)

    Esbroek MLP van; Schouten AJ; LBG

    1999-01-01

    Dit rapport is het zesde en laatste bodembiologisch rapport van de eerste meetnetronde binnen het Landelijk Meetnet Bodemkwaliteit (periode 1993 - 1997). Het geeft een beschrijving van de nematodenfauna gevonden binnen de drie categoriekn MVH (melkveehouderijbedrijven) op rivierklei, MVH op zeek

  2. Does the Op-Ed Page Have a Chance to Become a Public Forum?

    Science.gov (United States)

    Ciofalo, Andrew; Traverso, Kim

    1994-01-01

    Surveys op-ed page editors, finding that fewer than half of the responding papers have op-ed pages; that professional journalists, public figures, and propagandists dominate the pages; and that editors firmly control the agenda. (SR)

  3. Economic and policy implications of the cumulative carbon budget

    Science.gov (United States)

    Allen, M. R.; Otto, F. E. L.; Otto, A.; Hepburn, C.

    2014-12-01

    The importance of cumulative carbon emissions in determining long-term risks of climate change presents considerable challenges to policy makers. The traditional notion of "total CO2-equivalent emissions", which forms the backbone of agreements such as the Kyoto Protocol and the European Emissions Trading System, is fundamentally flawed. Measures to reduce short-lived climate pollutants benefit the current generation, while measures to reduce long-lived climate pollutants benefit future generations, so there is no sense in which they can ever be considered equivalent. Debates over the correct metric used to compute CO2-equivalence are thus entirely moot: both long-lived and short-lived emissions will need to be addressed if all generations are to be protected from dangerous climate change. As far as long-lived climate pollutants are concerned, the latest IPCC report highlights the overwhelming importance of carbon capture and storage in determining the cost of meeting the goal of limiting anthropogenic warming to two degrees. We will show that this importance arises directly from the cumulative carbon budget and the role of CCS as the technology of last resort before economic activity needs to be restricted to meet ambitious climate targets. It highlights the need to increase the rate of CCS deployment by orders of magnitude if the option of avoiding two degrees is to be retained. The difficulty of achieving this speed of deployment through conventional incentives and carbon-pricing mechanisms suggests a need for a much more direct mandatory approach. Despite their theoretical economic inefficiency, the success of recent regulatory measures in achieving greenhouse gas emissions reductions in jurisdictions such as the United States suggests an extension of the regulatory approach could be a more effective and politically acceptable means of achieving adequately rapid CCS deployment than conventional carbon taxes or cap-and-trade systems.

  4. A randomized controlled trial testing the effectiveness of a universal school-based depression prevention program 'Op Volle Kracht' in the Netherlands

    NARCIS (Netherlands)

    Tak, Y.R.; Zundert, R.M.P. van; Kuijpers, R.C.W.M.; Vlokhoven, B.S. van; Rensink, H.F.W.; Engels, R.C.M.E.

    2012-01-01

    Background: The incidence of depressive symptoms increases during adolescence, from 10.0% to 24.5% at age 11 to 15, respectively. Experiencing elevated levels of depressive symptoms increases the risk of a depressive disorder in adulthood. A universal school-based depression prevention program Op

  5. Long and Short Term Cumulative Structural Priming Effects.

    Science.gov (United States)

    Kaschak, Michael P; Kutta, Timothy J; Coyle, Jacqueline M

    We present six experiments that examine cumulative structural priming effects (i.e., structural priming effects that accumulate across many utterances). Of particular interest is whether (1) cumulative priming effects transfer across language production tasks and (2) the transfer of cumulative priming effects across tasks persists over the course of a week. Our data suggest that cumulative structural priming effects do transfer across language production tasks (e.g., from written stem completion to picture description, and from picture description to written stem completion), but only when both tasks are presented in the same experimental session. When cumulative priming effects are established in one task, and the second (changed) task is not presented until a week later, the cumulative priming effects are not observed.

  6. Why Veterinary Medical Educators Should Embrace Cumulative Final Exams.

    Science.gov (United States)

    Royal, Kenneth D

    2017-01-03

    The topic of cumulative final examinations often elicits polarizing opinions from veterinary medical educators. While some faculty prefer cumulative finals, there are many who perceive these types of examinations as problematic. Specifically, faculty often cite cumulative examinations are more likely to cause students' greater stress, which may in turn result in negative student evaluations of teaching. Cumulative finals also restrict the number of items one may present to students on most recent material. While these cited disadvantages may have some merit, the advantages of cumulative examinations far exceed the disadvantages. The purpose of this article is to discuss the advantages of cumulative examinations with respect to learning evidence, grade/score validity, fairness issues, and implications for academic policy.

  7. Prokofiev: Piano Concertos - N1 in Dflat major, Op. 10 / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1990-01-01

    Uuest heliplaadist "Prokofiev: Piano Concertos - N1 in Dflat major, Op. 10, N4 in Bflat major, Op.53 "for the left hand", N5 in Gmajor, Op.55. Boris Berman (piano) Royal Concertgebouw Orchestra, Neeme Järvi". Chandos ABTD 1424. CHAN 8791

  8. Gravitational Couplings for Gop-Planes and y-Op-Planes

    CERN Document Server

    Ospina-Giraldo, J F

    2000-01-01

    The Wess-Zumino actions for generalized orientifold planes (GOp-planes) and y-deformed orientifold planes (yOp-planes) are presented and two series power expantions are realized from whiches processes that involves GOp-planes,yOp-planes, RR-forms, gravitons and gaugeons, are obtained. Finally non-standard GOp-planes and y-Op-planes are showed.

  9. NGO's op Curacao: identificatie van belangrijke knelpunten en voorstellen tot verbetering

    NARCIS (Netherlands)

    Elias, Michael; Halman, Joop; Knigge, Siert; Sophia, Rudsel

    2009-01-01

    Dit rapport beschrijft een onderzoek onder Niet-Gouvernementele Organisaties (NGO’s) op Curaçao dat op verzoek van de AMFO door de stichting ABC Advies is uitgevoerd. In het onderzoek dat plaatsvond in de periode van 26 oktober t/m 2 november 2009 zijn belangrijke knelpunten die leven bij NGO’s op C

  10. Wortellesieaaltjes in amaryllis (Hippeastrum) : invloed van de temperatuur op de vermeerdering : populatieontwikkeling en schadelijkheid

    NARCIS (Netherlands)

    Stapel, L.H.M.

    2005-01-01

    In de teelt van amaryllis kunnen twee soorten wortellesieaaltjes wortelrot veroorzaken. In bestaande kennis is geen informatie beschikbaar over de invloed van de temperatuur op de vermeerdering op de waardplant amaryllis op deze aaltjes, in welke mate deze aaltjes zich in de loop van de teelt kunnen

  11. Prokofiev: Piano Concertos - N1 in Dflat major, Op. 10 / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1990-01-01

    Uuest heliplaadist "Prokofiev: Piano Concertos - N1 in Dflat major, Op. 10, N4 in Bflat major, Op.53 "for the left hand", N5 in Gmajor, Op.55. Boris Berman (piano) Royal Concertgebouw Orchestra, Neeme Järvi". Chandos ABTD 1424. CHAN 8791

  12. Barber: Sinfonie Nr. 1, Op. 9, Neeme Järvi / Bernhard Uske

    Index Scriptorium Estoniae

    Uske, Bernhard

    1991-01-01

    Uuest heliplaadist "Barber: Sinfonie Nr. 1, Op. 9. Ouvertüre School for Scandal, Op. 5; Beach: Sinfonie e-Moll, Op. 32, "Gaelic". Detroit Symphony Orchestra /Neeme Järvi". Chandes cassette ABTD 1550; CD CHAN 8958 (72 minutes)

  13. GPS-logger onderzoek aan Buizerds helpt vogelaanvaringen op militaire vliegvelden te voorkomen

    NARCIS (Netherlands)

    van Gasteren, H.; Both, I; Shamoun-Baranes, J.; Laloë, J.O.; Bouten, W.

    2014-01-01

    Op de hele wereld is de aanwezigheid van vogels op en rond vliegvelden een probleem voor de vliegveiligheid, waarbij sommige vogelsoorten meer risico opleveren dan andere. Om de kans op ongelukken te verkleinen worden landingsterreinen vogelonaantrekkelijk beheerd, worden vogels verjaagd en soms

  14. Schostakowitsch: Sinfonie Nr. 12 op. 112 (Das Jahr 1917) / Hans-Christian Dadelsen

    Index Scriptorium Estoniae

    Dadelsen, Hans-Christian

    1991-01-01

    Uuest heliplaadist "Schostakowitsch: Sinfonie Nr. 12 op. 112 (Das Jahr 1917). Hamlet-Suite op. 32a. Das goldene Zeitalter [The Age of Gold] (Suite) op. 22a. Göteborger Symphoniker, Neeme Järvi". DG CD 431 688-2 (WD:77'21") DDD

  15. Schostakowitsch: Sinfonie Nr. 12 op. 112 (Das Jahr 1917) / Hans-Christian Dadelsen

    Index Scriptorium Estoniae

    Dadelsen, Hans-Christian

    1991-01-01

    Uuest heliplaadist "Schostakowitsch: Sinfonie Nr. 12 op. 112 (Das Jahr 1917). Hamlet-Suite op. 32a. Das goldene Zeitalter [The Age of Gold] (Suite) op. 22a. Göteborger Symphoniker, Neeme Järvi". DG CD 431 688-2 (WD:77'21") DDD

  16. Toezicht op seksuele geweldplegers na invrijheidstelling : Safe reintegration of sexual offenders

    NARCIS (Netherlands)

    Leuw, Ed.; Motiuk, L.L.; Marle, H.J.C. van

    2000-01-01

    Toezicht op bekende plegers van (pedo)seksuele geweldsdelicten is een onderwerp dat velen bezighoudt. Op dit moment bestaan plannen om in Nederland de wettelijke mogelijkheden voor toezicht op 'gevaarlijke' ex-delinquenten te verruimen. Deze bundel bevat twee bijdragen die inzicht geven in de bestaa

  17. GPS-logger onderzoek aan Buizerds helpt vogelaanvaringen op militaire vliegvelden te voorkomen

    NARCIS (Netherlands)

    H. van Gasteren; I Both; J. Shamoun-Baranes; J.O. Laloë; W. Bouten

    2014-01-01

    Op de hele wereld is de aanwezigheid van vogels op en rond vliegvelden een probleem voor de vliegveiligheid, waarbij sommige vogelsoorten meer risico opleveren dan andere. Om de kans op ongelukken te verkleinen worden landingsterreinen vogelonaantrekkelijk beheerd, worden vogels verjaagd en soms gev

  18. Religie, binding en polarisatie : de reacties van de leiding van levensbeschouwelijke organisaties op islamkritische uitingen

    NARCIS (Netherlands)

    Vellenga S.; Wiegers, G.

    2011-01-01

    In dit onderzoek is nagegaan hoe de leiding van levensbeschouwelijke (islamitische en niet-islamitische) organisaties in Nederland heeft gereageerd op islamkritische uitingen en welke factoren op deze reactie van invloed zijn geweest. Daarbij gaat de aandacht uit naar de reactie op de volgende vijf

  19. Visualization of candidate division OP3 cocci in limonene-degrading methanogenic cultures

    DEFF Research Database (Denmark)

    Rotaru, Amelia-Elena; Schauer, Regina; Probian, Christina

    2012-01-01

    Members of candidate division OP3 were detected in 16S rRNA gene clone libraries from methanogenic enrichment cultures that utilized limonene as a carbon and energy source. We developed probes for the visualization of OP3 cells. In situ hybridization experiments with newly designed OP3-specific...

  20. Analysis of experimental data on correlations between cumulative particles

    Energy Technology Data Exchange (ETDEWEB)

    Vlasov, A.V.; Doroshkevich, E.A.; Leksin, G.A. [Institute of Theoretical and Experimental Physics, Moscow (Russian Federation)] [and others

    1995-04-01

    Experimental data on correlations between cumulative particles are analyzed. A space-time and energy-transfer pattern of hadron-nucleus interaction based on both correlation data and data on the inclusive spectra of cumulative particles is considered. A new variable that is convenient for describing the production of cumulative particles is proposed using the concept of symmetry between the one-particle and multiparticle distributions. 32 refs., 9 figs., 1 tab.