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Sample records for onset muscle soreness

  1. Delayed onset muscle soreness: is massage effective?

    Science.gov (United States)

    Nelson, Nicole

    2013-10-01

    Despite the widespread occurrence of delayed onset muscle soreness (DOMS), there is little consensus as to the exact cause or which treatments may be most effective at alleviating symptoms. Greater understanding of DOMS can give sports medicine and fitness professionals an opportunity to help prevent or speed recovery of this performance limiting condition. This article will review the DOMS literature, including the potential role of psychosocial factors and explore studies which involve massage therapy as a treatment modality. Articles from PubMed, MEDLINE, Google Scholar, and references from articles are included in this review. Search words and phrases included delayed onset muscle soreness, repeated bout effect, massage effectiveness, exercise induced muscle damage, and eccentric exercise.

  2. Laser homeostatics on delayed onset muscle soreness

    Science.gov (United States)

    Liu, T. C. Y.; Fu, D. R.; Liu, X. G.; Tian, Z. X.

    2011-01-01

    Delayed onset muscle soreness (DOMS) and its photobiomodulation were reviewed from the viewpoint of function-specific homeostasis (FSH) in this paper. FSH is a negative-feedback response of a biosystem to maintain the function-specific fluctuations inside the biosystem so that the function is perfectly performed. A stressor may destroy a FSH. A stress is a response of a biosystem to a stressor and may also be in stress-specific homeostasis (StSH). A low level light (LLL) is so defined that it has no effects on a function in its FSH or a stress in its StSH, but it modulate a function far from its FSH or a stress far from its StSH. For DOMS recovery, protein metabolism in the Z-line streaming muscular cell is the essential process, but the inflammation, pain and soreness are non-essential processes. For many DOMS phenomena, protein metabolism in the Z-line streaming muscular cell is in protein metabolism-specific homeostasis (PmSH) so that there are no effects of LLL although the inflammation can be inhibited and the pain can be relieved. An athlete or animal in the dysfunctional conditions such as blood flow restriction and exercise exhaustion is far from PmSH and the protein metabolism can be improved with LLL.

  3. Recommendations for the Avoidance of Delayed-Onset Muscle Soreness.

    Science.gov (United States)

    Szymanski, David J.

    2001-01-01

    Describes the possible causes of delayed-onset muscle soreness (DOMS), which include buildup of lactic acid in muscle, increased intracellular calcium concentration, increased intramuscular inflammation, and muscle fiber and connective tissue damage. Proposed methods to reduce DOMS include warming up before exercise and performing repeated bouts…

  4. Effects of delayed-onset muscle soreness on masticatory function

    NARCIS (Netherlands)

    Yoshida, E.; Lobbezoo, F.; Fueki, K.; Naeije, M.

    2012-01-01

    The aim was to clarify the effects of experimentally provoked delayed-onset muscle soreness (DOMS) in the jaw-closing muscles on subjective and objective measures of masticatory function. Twenty-one dentate female subjects, without pain-related signs and symptoms of temporomandibular disorders, part

  5. Vibration Therapy in Management of Delayed Onset Muscle Soreness (DOMS)

    OpenAIRE

    Veqar, Zubia; Imtiyaz, Shagufta

    2014-01-01

    Both athletic and nonathletic population when subjected to any unaccustomed or unfamiliar exercise will experience pain 24-72 hours postexercise. This exercise especially eccentric in nature caused primarily by muscle damage is known as delayed-onset muscle soreness (DOMS). This damage is characterized by muscular pain, decreased muscle force production, reduce range of motion and discomfort experienced. DOMS is due to microscopic muscle fiber tears. The presence of DOMS increases risk of inj...

  6. The effects of massage on delayed onset muscle soreness

    Science.gov (United States)

    Hilbert, J; Sforzo, G; Swensen, T

    2003-01-01

    Objectives: The purpose of this study was to investigate the physiological and psychological effects of massage on delayed onset muscle soreness (DOMS). Methods: Eighteen volunteers were randomly assigned to either a massage or control group. DOMS was induced with six sets of eight maximal eccentric contractions of the right hamstring, which were followed 2 h later by 20 min of massage or sham massage (control). Peak torque and mood were assessed at 2, 6, 24, and 48 h postexercise. Range of motion (ROM) and intensity and unpleasantness of soreness were assessed at 6, 24, and 48 h postexercise. Neutrophil count was assessed at 6 and 24 h postexercise. Results: A two factor ANOVA (treatment v time) with repeated measures on the second factor showed no significant treatment differences for peak torque, ROM, neutrophils, unpleasantness of soreness, and mood (p > 0.05). The intensity of soreness, however, was significantly lower in the massage group relative to the control group at 48 h postexercise (p < 0.05). Conclusions: Massage administered 2 h after exercise induced muscle injury did not improve hamstring function but did reduce the intensity of soreness 48 h after muscle insult. PMID:12547748

  7. The effect of caffeine ingestion on delayed onset muscle soreness.

    Science.gov (United States)

    Hurley, Caitlin F; Hatfield, Disa L; Riebe, Deborah A

    2013-11-01

    The beneficial effects of caffeine on aerobic activity and resistance training performance are well documented. However, less is known concerning caffeine's potential role in reducing perception of pain and soreness during exercise. In addition, there is no information regarding the effects of caffeine on delayed onset muscle soreness (DOMS). The primary purpose of this study was to examine the effect of caffeine ingestion on muscle soreness, blood enzyme activity, and performance after a bout of elbow flexion/extension exercise. Nine low-caffeine-consuming males (body mass: 76.68 ± 8.13 kg; height: 179.18 ± 9.35 cm; age: 20 ± 1 year) were randomly assigned to ingest either caffeine or placebo 1 hour before completing 4 sets of 10 bicep curls on a preacher bench, followed by a fifth set in which subjects completed as many repetitions as possible. Soreness and soreness on palpation intensity were measured using three 0-10 visual analog scales before exercise, and 24, 48, 72, 96, and 120 hours after exercise. After a washout period, subjects crossed over to the other treatment group. Caffeine ingestion resulted in significantly (p ≤ 0.05) lower levels of soreness on day 2 and day 3 compared with placebo. Total repetitions in the final set of exercise increased with caffeine ingestion compared with placebo. This study demonstrates that caffeine ingestion immediately before an upper-body resistance training out enhances performance. A further beneficial effect of sustained caffeine ingestion in the days after the exercise bout is an attenuation of DOMS. This decreased perception of soreness in the days after a strenuous resistance training workout may allow individuals to increase the number of training sessions in a given time period.

  8. Ultrasound Findings of Delayed-Onset Muscle Soreness.

    Science.gov (United States)

    Longo, Victor; Jacobson, Jon A; Fessell, David P; Mautner, Kenneth

    2016-11-01

    The purpose of this series was to retrospectively characterize the ultrasound findings of delayed-onset muscle soreness (DOMS). The Institutional Review Board approved our study, and informed consent was waived. A retrospective search of radiology reports using the key phrase "delayed-onset muscle soreness" and key word "DOMS" from 2001 to 2015 and teaching files was completed to identify cases. The sonograms were reviewed by 3 fellowship-trained musculoskeletal radiologists by consensus. Sonograms were retrospectively characterized with respect to echogenicity (hypoechoic, isoechoic, or hyperechoic), distribution of muscle involvement, and intramuscular pattern (focal versus diffuse and well defined versus poorly defined). Images were also reviewed for muscle enlargement, fluid collection, muscle fiber disruption, and increased flow on color or power Doppler imaging. There were a total of 6 patients identified (5 male and 1 female). The average age was 22 years (range, 7-44 years). Of the 6 patients, there were a total of 11 affected muscles in 7 extremities (1 bilateral case). The involved muscles were in the upper extremity: triceps brachii in 27% (3 of 11), biceps brachii in 18% (2 of 11), brachialis in 18% (2 of 11), brachioradialis in 18% (2 of 11), infraspinatus in 9% (1 of 11), and deltoid in 9% (1 of 11). On ultrasound imaging, the abnormal muscle was hyperechoic in 100% (11 of 11), well defined in 73% (8 of 11), poorly defined in 27% (3 of 11), diffuse in 73% (8 of 11), and focal in 27% (3 of 11). Increased muscle size was found in 82% (9 of 11) and minimal hyperemia in 87.5% (7 of 8). The ultrasound findings of DOMS include hyperechoic involvement of an upper extremity muscle, most commonly appearing well defined and diffuse with increased muscle size and minimal hyperemia.

  9. Vibration Therapy in Management of Delayed Onset Muscle Soreness (DOMS).

    Science.gov (United States)

    Veqar, Zubia; Imtiyaz, Shagufta

    2014-06-01

    Both athletic and nonathletic population when subjected to any unaccustomed or unfamiliar exercise will experience pain 24-72 hours postexercise. This exercise especially eccentric in nature caused primarily by muscle damage is known as delayed-onset muscle soreness (DOMS). This damage is characterized by muscular pain, decreased muscle force production, reduce range of motion and discomfort experienced. DOMS is due to microscopic muscle fiber tears. The presence of DOMS increases risk of injury. A reduced range of motion may lead to the incapability to efficiently absorb the shock that affect physical activity. Alterations to mechanical motion may increase strain placed on soft tissue structures. Reduced force output may signal compensatory recruitment of muscles, thus leading to unaccustomed stress on musculature. Differences in strength ratios may also cause excessive strain on unaccustomed musculature. A range of interventions aimed at decreasing symptoms of DOMS have been proposed. Although voluminous research has been done in this regard, there is little consensus among the practitioners regarding the most effective way of treating DOMS. Mechanical oscillatory motion provided by vibration therapy. Vibration could represent an effective exercise intervention for enhancing neuromuscular performance in athletes. Vibration has shown effectiveness in flexibility and explosive power. Vibration can apply either local area or whole body vibration. Vibration therapy improves muscular strength, power development, kinesthetic awareness, decreased muscle sore, increased range of motion, and increased blood flow under the skin. VT was effective for reduction of DOMS and regaining full ROM. Application of whole body vibration therapy in postexercise demonstrates less pressure pain threshold, muscle soreness along with less reduction maximal isometric and isokinetic voluntary strength and lower creatine kinase levels in the blood.

  10. Delayed onset muscle soreness : treatment strategies and performance factors.

    Science.gov (United States)

    Cheung, Karoline; Hume, Patria; Maxwell, Linda

    2003-01-01

    Delayed onset muscle soreness (DOMS) is a familiar experience for the elite or novice athlete. Symptoms can range from muscle tenderness to severe debilitating pain. The mechanisms, treatment strategies, and impact on athletic performance remain uncertain, despite the high incidence of DOMS. DOMS is most prevalent at the beginning of the sporting season when athletes are returning to training following a period of reduced activity. DOMS is also common when athletes are first introduced to certain types of activities regardless of the time of year. Eccentric activities induce micro-injury at a greater frequency and severity than other types of muscle actions. The intensity and duration of exercise are also important factors in DOMS onset. Up to six hypothesised theories have been proposed for the mechanism of DOMS, namely: lactic acid, muscle spasm, connective tissue damage, muscle damage, inflammation and the enzyme efflux theories. However, an integration of two or more theories is likely to explain muscle soreness. DOMS can affect athletic performance by causing a reduction in joint range of motion, shock attenuation and peak torque. Alterations in muscle sequencing and recruitment patterns may also occur, causing unaccustomed stress to be placed on muscle ligaments and tendons. These compensatory mechanisms may increase the risk of further injury if a premature return to sport is attempted.A number of treatment strategies have been introduced to help alleviate the severity of DOMS and to restore the maximal function of the muscles as rapidly as possible. Nonsteroidal anti-inflammatory drugs have demonstrated dosage-dependent effects that may also be influenced by the time of administration. Similarly, massage has shown varying results that may be attributed to the time of massage application and the type of massage technique used. Cryotherapy, stretching, homeopathy, ultrasound and electrical current modalities have demonstrated no effect on the alleviation of

  11. Delayed onset muscle soreness: Involvement of neurotrophic factors.

    Science.gov (United States)

    Mizumura, Kazue; Taguchi, Toru

    2016-01-01

    Delayed-onset muscle soreness (DOMS) is quite a common consequence of unaccustomed strenuous exercise, especially exercise containing eccentric contraction (lengthening contraction, LC). Its typical sign is mechanical hyperalgesia (tenderness and movement related pain). Its cause has been commonly believed to be micro-damage of the muscle and subsequent inflammation. Here we present a brief historical overview of the damage-inflammation theory followed by a discussion of our new findings. Different from previous observations, we have observed mechanical hyperalgesia in rats 1-3 days after LC without any apparent microscopic damage of the muscle or signs of inflammation. With our model we have found that two pathways are involved in inducing mechanical hyperalgesia after LC: activation of the B2 bradykinin receptor-nerve growth factor (NGF) pathway and activation of the COX-2-glial cell line-derived neurotrophic factor (GDNF) pathway. These neurotrophic factors were produced by muscle fibers and/or satellite cells. This means that muscle fiber damage is not essential, although it is sufficient, for induction of DOMS, instead, NGF and GDNF produced by muscle fibers/satellite cells play crucial roles in DOMS.

  12. Is myofascial pain in temporomandibular disorder patients a manifestation of delayed-onset muscle soreness?

    NARCIS (Netherlands)

    Koutris, M.; Lobbezoo, F.; Sümer, N.C.; Atis, E.S.; Türker, K.S.; Naeije, M.

    2013-01-01

    Objective: In a study to the possible role of overuse of the jaw muscles in the pathogenesis of jaw muscle pain, we used a protocol involving concentric and eccentric muscle contractions to provoke a state of delayed-onset muscle soreness (DOMS) in the jaw muscles of healthy individuals. We tested

  13. Is myofascial pain in temporomandibular disorder patients a manifestation of delayed-onset muscle soreness?

    NARCIS (Netherlands)

    Koutris, M.; Lobbezoo, F.; Sümer, N.C.; Atis, E.S.; Türker, K.S.; Naeije, M.

    2013-01-01

    Objective: In a study to the possible role of overuse of the jaw muscles in the pathogenesis of jaw muscle pain, we used a protocol involving concentric and eccentric muscle contractions to provoke a state of delayed-onset muscle soreness (DOMS) in the jaw muscles of healthy individuals. We tested w

  14. Evaluation of the effectiveness of kinesiotaping in reducing delayed onset muscle soreness of the biceps brachii

    Directory of Open Access Journals (Sweden)

    Boguszewski Dariusz

    2016-07-01

    Full Text Available biological regeneration in athletes. The aim of this study was to evaluate the effectiveness of the application of lymphatic kinesiotaping in reducing delayed onset muscle soreness of biceps brachii.

  15. Effects of Massage on Delayed-Onset Muscle Soreness, Swelling, and Recovery of Muscle Function

    Science.gov (United States)

    Zainuddin, Zainal; Newton, Mike; Sacco, Paul; Nosaka, Kazunori

    2005-01-01

    Context: Delayed-onset muscle soreness (DOMS) describes muscle pain and tenderness that typically develop several hours postexercise and consist of predominantly eccentric muscle actions, especially if the exercise is unfamiliar. Although DOMS is likely a symptom of eccentric-exercise–induced muscle damage, it does not necessarily reflect muscle damage. Some prophylactic or therapeutic modalities may be effective only for alleviating DOMS, whereas others may enhance recovery of muscle function without affecting DOMS. Objective: To test the hypothesis that massage applied after eccentric exercise would effectively alleviate DOMS without affecting muscle function. Design: We used an arm-to-arm comparison model with 2 independent variables (control and massage) and 6 dependent variables (maximal isometric and isokinetic voluntary strength, range of motion, upper arm circumference, plasma creatine kinase activity, and muscle soreness). A 2-way repeated-measures analysis of variance and paired t tests were used to examine differences in changes of the dependent variable over time (before, immediately and 30 minutes after exercise, and 1, 2, 3, 4, 7, 10, and 14 days postexercise) between control and massage conditions. Setting: University laboratory. Patients or Other Participants: Ten healthy subjects (5 men and 5 women) with no history of upper arm injury and no experience in resistance training. Intervention(s): Subjects performed 10 sets of 6 maximal isokinetic (90°·s−1) eccentric actions of the elbow flexors with each arm on a dynamometer, separated by 2 weeks. One arm received 10 minutes of massage 3 hours after eccentric exercise; the contralateral arm received no treatment. Main Outcome Measure(s): Maximal voluntary isometric and isokinetic elbow flexor strength, range of motion, upper arm circumference, plasma creatine kinase activity, and muscle soreness. Results: Delayed-onset muscle soreness was significantly less for the massage condition for peak

  16. Homoeopathy for delayed onset muscle soreness: a randomised double blind placebo controlled trial.

    Science.gov (United States)

    Vickers, A J; Fisher, P; Smith, C; Wyllie, S E; Lewith, G T

    1997-01-01

    OBJECTIVE: To pilot a model for determining whether a homoeopathic medicine is superior to placebo for delayed onset muscle soreness (DOMS). DESIGN: Randomised double blind placebo controlled trial. SETTING: Physiotherapy department of a homoeopathic hospital. SUBJECTS: Sixty eight healthy volunteers (average age 30; 41% men) undertook a 10 minute period of bench stepping carrying a small weight and were randomised to a homoeopathic medicine or placebo. OUTCOME MEASURES: Mean muscle soreness in the five day period after the exercise test, symptom free days, maximum soreness score, days to no soreness, days on medication. RESULTS: The difference between group means was 0.17 in favour of placebo with 95% confidence intervals +/- 0.50. Similar results were found for other outcome measures. CONCLUSION: The study did not find benefit of the homoeopathic remedy in DOMS. Bench stepping may not be an appropriate model to evaluate the effects of a treatment on DOMS because of wide variation between subject soreness scores. PMID:9429007

  17. Delayed Onset Muscle Soreness After Inspiratory Threshold Loading in Healthy Adults

    Science.gov (United States)

    Mathur, Sunita; Sheel, A. William; Road, Jeremy D.; Reid, W. Darlene

    2010-01-01

    Purpose: Skeletal muscle damage occurs following high-intensity or unaccustomed exercise; however, it is difficult to monitor damage to the respiratory muscles, particularly in humans. The aim of this study was to use clinical measures to investigate the presence of skeletal muscle damage in the inspiratory muscles. Methods: Ten healthy subjects underwent 60 minutes of voluntary inspiratory threshold loading (ITL) at 70% of maximal inspiratory pressure. Maximal inspiratory and expiratory mouth pressures, delayed onset muscle soreness on a visual analogue scale and plasma creatine kinase were measured prior to ITL, and at repeated time points after ITL (4, 24 and 48 hours post-ITL). Results: Delayed onset muscle soreness was present in all subjects 24 hours following ITL (intensity = 22 ± 6 mm; significantly higher than baseline p = 0.02). Muscle soreness was reported primarily in the anterior neck region, and was correlated to the amount of work done by the inspiratory muscles during ITL (r = 0.72, p = 0.02). However, no significant change was observed in maximal inspiratory or expiratory pressures or creatine kinase. Conclusions: These findings suggest that an intense bout of ITL results in muscle soreness primarily in the accessory muscles of inspiration, however, may be insufficient to cause significant muscle damage in healthy adults. PMID:20467514

  18. Pulsed Ultrasound Fails To Diminish Delayed-Onset Muscle Soreness Symptoms

    Science.gov (United States)

    Stay, Jeffrey C.; Richard, Mark D.; Draper, David O.; Schulthies, Shane S.; Durrant, Earlene

    1998-01-01

    Objective: We investigated the effects of pulsed ultrasound on swelling, muscle soreness perception, relaxed-elbow extension angle, and muscular strength. Design and Setting: Eight sets of concentric and eccentric actions induced delayed-onset muscle soreness of the elbow flexors. Group 1 received 20% pulsed ultrasound treatments (1-MHz, 7 minutes, 1.5 W/ cm2 temporal peak intensity) twice a day immediately after postexercise assessments and at 3, 24, 27, 48, 51, 72, and 75 hours postexercise. Group 2 received sham treatments immediately after postexercise assessments and at 3,27, 51, and 75 hours postexercise and true treatments of pulsed ultrasound at 24, 48, and 72 hours postexercise. Group 3 received sham treatments of no ultrasonic output immediately after postexercise assessments and at 3, 24, 27, 48, 51, 72, and 75 hours postexercise. Subjects: Thirty-six college-age females. Measurements: We recorded upper-arm circumference, perceived soreness, relaxed-elbow extension angle, and elbow-flexion strength before (pretest), immediately postexercise, and at 24, 48, 72, and 96 hours postexercise. Results: We noted differences over time but no treatment effect between groups or interactions between time and group for upper-arm circumference, perceived soreness, relaxed-elbow extension angle, or elbow-flexion strength. Conclusions: Pulsed ultrasound as used in this study did not significantly diminish the effects of delayed-onset muscle soreness on soreness perception, swelling, relaxed-elbow extension angle, and strength. PMID:16558532

  19. Effect of warm-up exercise on delayed-onset muscle soreness

    OpenAIRE

    Takizawa, Kazuki; Soma, Toshio; Nosaka, Kazunori; Ishikawa, Tomoji; Ishii, Kojiro

    2011-01-01

    This study investigated whether a warm-up exercise consisting of 100 submaximal concentric contractions would attenuate delayed-onset muscle soreness (DOMS) and decreases in muscle strength associated with eccentric exercise-induced muscle damage. Ten male students performed two bouts of the elbow flexor exercise consisting of 12 maximal eccentric contractions with a warm-up exercise for one arm (WU) and without warm-up for the other arm (control: CON) in a randomised, counterbalanced order s...

  20. Interleukin-6 and Delayed Onset Muscle Soreness Do Not Vary during the Menstrual Cycle

    Science.gov (United States)

    Chaffin, Morgan E.; Berg, Kris E.; Meendering, Jessica R.; Llewellyn, Tamra L.; French, Jeffrey A.; Davis, Jeremy E.

    2011-01-01

    The purpose of this study was to determine if a difference in interleukin-6 (IL-6) and delayed onset muscles soreness (DOMS) exists in two different phases of the menstrual cycle. Nine runners performed one 75-min high-intensity interval running session during the early follicular (EF) phase and once during the midluteal (ML) phase of the…

  1. Interleukin-6 and Delayed Onset Muscle Soreness Do Not Vary during the Menstrual Cycle

    Science.gov (United States)

    Chaffin, Morgan E.; Berg, Kris E.; Meendering, Jessica R.; Llewellyn, Tamra L.; French, Jeffrey A.; Davis, Jeremy E.

    2011-01-01

    The purpose of this study was to determine if a difference in interleukin-6 (IL-6) and delayed onset muscles soreness (DOMS) exists in two different phases of the menstrual cycle. Nine runners performed one 75-min high-intensity interval running session during the early follicular (EF) phase and once during the midluteal (ML) phase of the…

  2. Effects of Zingiber cassumunar(Plai cream) in the treatment of delayed onset muscle soreness

    Institute of Scientific and Technical Information of China (English)

    Nuttaset Manimmanakorn; Apiwan Manimmanakorn; Disaphon Boobphachart; Worrawut Thuwakum; Wiroon Laupattarakasem; Michael J Hamlin

    2016-01-01

    OBJECTIVE:To evaluate the effects ofZingiber cassumunar (Plai cream) in either 7% or 14%concentration on delayed onset muscle soreness (DOMS). METHODS: Seventy-ifve untrained healthy volunteers (28 males and 47 females), performed 4 sets of 25 eccentric repetitions of the dominant quadriceps muscle on an isokinetic dynamometry machine. Participants were then randomized into 3 groups: 14% Plai cream, 7% Plai cream and placebo cream. Two grams of the cream (strips of 5-cm long) were gently rubbed into the quadriceps muscles for 5 min immediately folowing the exercise and every 8 h thereafter for 7 d in al groups. Muscle soreness, muscle strength, jump height, thigh circumference and creatine kinase were measured before and after eccentric exercise. RESULTS:Compared to the placebo cream the 14% Plai cream substantialy reduced muscle soreness over the 7 d by –82% (95% CI = –155% to –6%,P = 0.03), but had similar muscle soreness effects to 7% Plai cream (–34%, –96% to 27%,P = 0.2). Compared to the placebo cream the 7% Plai cream resulted in a smal non-signiifcant reduction in muscle soreness levels over the folowing 7 d (–40%,–116% to 36%,P = 0.3). Compared to placebo cream there was little effect of Plai cream (7% or 14%) on muscle strength, jump height, thigh circumference or creatine kinase concentration. CONCLUSION:Using 14% Plai cream over a 7-day period substantialy reduced muscle soreness symptoms compared to 7% Plai cream or a placebo cream. The authors suggest that the administration of 14% Plai cream is a useful alternative in the management of DOMS. TRIAL REGISTRATION: Thai Clinical Trial Registry TCTR20140215001.

  3. Effects of Zingiber cassumunar (Plai cream) in the treatment of delayed onset muscle soreness.

    Science.gov (United States)

    Manimmanakorn, Nuttaset; Manimmanakorn, Apiwan; Boobphachart, Disaphon; Thuwakum, Worrawut; Laupattarakasem, Wiroon; Hamlin, Michael J

    2016-03-01

    To evaluate the effects of Zingiber cassumunar (Plai cream) in either 7% or 14% concentration on delayed onset muscle soreness (DOMS). Seventy-five untrained healthy volunteers (28 males and 47 females), performed 4 sets of 25 eccentric repetitions of the dominant quadriceps muscle on an isokinetic dynamometry machine. Participants were then randomized into 3 groups: 14% Plai cream, 7% Plai cream and placebo cream. Two grams of the cream (strips of 5-cm long) were gently rubbed into the quadriceps muscles for 5 min immediately following the exercise and every 8 h thereafter for 7 d in all groups. Muscle soreness, muscle strength, jump height, thigh circumference and creatine kinase were measured before and after eccentric exercise. Compared to the placebo cream the 14% Plai cream substantially reduced muscle soreness over the 7 d by -82% (95% CI = -155% to -6%, P = 0.03), but had similar muscle soreness effects to 7% Plai cream (-34%, -96% to 27%, P = 0.2). Compared to the placebo cream the 7% Plai cream resulted in a small non-significant reduction in muscle soreness levels over the following 7 d (-40%, -116% to 36%, P = 0.3). Compared to placebo cream there was little effect of Plai cream (7% or 14%) on muscle strength, jump height, thigh circumference or creatine kinase concentration. Using 14% Plai cream over a 7-day period substantially reduced muscle soreness symptoms compared to 7% Plai cream or a placebo cream. The authors suggest that the administration of 14% Plai cream is a useful alternative in the management of DOMS. Thai Clinical Trial Registry TCTR20140215001.

  4. Pulsed Ultrasound Does Not Affect Recovery From Delayed Onset Muscle Soreness

    Directory of Open Access Journals (Sweden)

    Gauri Shankar

    2006-07-01

    Full Text Available Aim: To investigate the effects of pulsed Ultrasound (US in recovery from Delayed Onset Muscle Soreness (DOMS. Methods: Twelve healthy male athletes (mean age 23.83±1.697 year performed an eccentric exercise protocol of non-dominant elbow flexors to induce muscle soreness on 2 occasions separated by 3 weeks. Subjects in experimental group received pulsed US (1 MHz, intensity 0.8 W/cm2, mark space ratio 1:10, whereas control group received sham US after 24 h, 48 h and 72 h. Perception of muscle soreness, active ROM and muscle strength were the parameters measured at 0 h, 24 h, 48 h and 72 h with the help of VAS, manual goniometer and JONEX muscles master instrument respectively. Results: Post hoc t test analysis revealed significant differences (p <0.05 between 0 h and 72 h in the parameter of ROM (t = 6.18 and muscle power (t = 2.54 as well as between 24 h and 48 h in the parameter of muscle soreness (t = 3.13 in control group. Similar differences were also observed in the experimental group. No significant inter-group differences at α level of 0.05 was observed in any parameter at any level. Conclusion: The pattern of recovery from DOMS was not influenced by the application of pulsed Ultrasound at the parameters discussed here.

  5. The affect on delayed onset muscle soreness recovery for ultrasound with bee venom.

    Science.gov (United States)

    Kim, Seung Kyun; Kim, Myung Chul

    2014-09-01

    [Purpose] The purpose of this study was to evaluate whether ultrasound alone or ultrasound with bee venom is effective in treating delayed onset muscle soreness of the biceps brachii muscle, using the visual analogue scale, range of motion test (flexion and extension), and serum creatine kinase level. [Subjects] Twenty women participated in this study. [Methods] Repeated eccentric contractions were used to induce delayed onset muscle soreness in the elbow flexor of the subjects. The subjects were randomized to be treated with ultrasound alone or ultrasound with bee venom. We evaluated the effects of treatments in the 2 groups. Individual subjects were assessed using the visual analogue scale, range of motion test, and serum creatine kinase level. The assessment parameters were evaluated 4 times: before exercise and 24, 48, and 72 hours after exercise. [Results] The visual analogue scale scores were significantly different before and after the experiment in both the group treated with ultrasound and the group treated with ultrasound and bee venom. The difference in elbow flexion and extension before and after the experiment was significantly different in both groups. No significant difference was found in the serum creatine kinase levels before and after the experiment. [Conclusion] Treatment with ultrasound and bee venom is effective for managing delayed onset muscle soreness.

  6. Effect of Whirlpool Therapy on the Signs and Symptoms of Delayed-Onset Muscle Soreness

    Science.gov (United States)

    Kuligowski, Lori A.; Lephart, Scott M.; Giannantonio, Frank P.; Blanc, Rob O.

    1998-01-01

    Objective: To determine the efficacy of warm whirlpool, cold whirlpool, and contrast therapy in the treatment of delayed-onset muscle soreness. Design and Setting: Subjects performed eccentric contractions of the elbow flexors and received 4 treatments: immediately postexercise and 24, 48, and 72 hours postexercise. Treatments consisted of 24-minute treatments with warm whirlpool, cold whirlpool, contrast therapy, or no treatment. Subjects: Fifty-six sex-matched volunteers from the University of Pittsburgh. Measurements: Measurements were taken at 5 assessment times: pre-exercise (0 hours); prior to treatment at 24, 48, and 72 hours postexercise; and at 96 hours postexercise. Dependent variables were degrees of resting elbow flexion, active elbow flexion, and extension; perceived soreness values on a Graphic Pain Rating Scale; and maximal voluntary isometric contraction. A repeated-measures analysis of variance (group by time) and Tukey post hoc analysis were used to determine which treatment groups differed significantly in returning subjects to pre-exercise values. Results: Cold whirlpool and contrast therapy were found to return subjects to baseline values of resting elbow flexion and perceived soreness significantly more than warm whirlpool or no treatment (P < .01). Additionally, warm whirlpool was found to be more effective than no treatment in the return of resting elbow flexion (P < .01). Conclusions: These results suggest that cold whirlpool and contrast therapy are more effective than warm whirlpool or no treatment in alleviating delayed-onset muscle soreness in the elbow flexors. PMID:16558514

  7. The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness.

    Science.gov (United States)

    Matsumura, Melissa D; Zavorsky, Gerald S; Smoliga, James M

    2015-06-01

    Ginger possesses analgesic and pharmacological properties mimicking non-steroidal antiinflammatory drugs. We aimed to determine if ginger supplementation is efficacious for attenuating muscle damage and delayed onset muscle soreness (DOMS) following high-intensity resistance exercise. Following a 5-day supplementation period of placebo or 4 g ginger (randomized groups), 20 non-weight trained participants performed a high-intensity elbow flexor eccentric exercise protocol to induce muscle damage. Markers associated with muscle damage and DOMS were repeatedly measured before supplementation and for 4 days following the exercise protocol. Repeated measures analysis of variance revealed one repetition maximum lift decreased significantly 24 h post-exercise in both groups (p < 0.005), improved 48 h post-exercise only in the ginger group (p = 0.002), and improved at 72 (p = 0.021) and 96 h (p = 0.044) only in the placebo group. Blood creatine kinase significantly increased for both groups (p = 0.015) but continued to increase only in the ginger group 72 (p = 0.006) and 96 h (p = 0.027) post-exercise. Visual analog scale of pain was significantly elevated following eccentric exercise (p < 0.001) and was not influenced by ginger. In conclusion, 4 g of ginger supplementation may be used to accelerate recovery of muscle strength following intense exercise but does not influence indicators of muscle damage or DOMS.

  8. Manual therapy ameliorates delayed-onset muscle soreness and alters muscle metabolites in rats.

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    Urakawa, Susumu; Takamoto, Kouichi; Nakamura, Tomoya; Sakai, Shigekazu; Matsuda, Teru; Taguchi, Toru; Mizumura, Kazue; Ono, Taketoshi; Nishijo, Hisao

    2015-02-01

    Delayed-onset muscle soreness (DOMS) can be induced by lengthening contraction (LC); it can be characterized by tenderness and movement-related pain in the exercised muscle. Manual therapy (MT), including compression of exercised muscles, is widely used as physical rehabilitation to reduce pain and promote functional recovery. Although MT is beneficial for reducing musculoskeletal pain (i.e. DOMS), the physiological mechanisms of MT remain unclear. In the present study, we first developed an animal model of MT in DOMS; LC was applied to the rat gastrocnemius muscle under anesthesia, which induced mechanical hyperalgesia 2-4 days after LC. MT (manual compression) ameliorated mechanical hyperalgesia. Then, we used capillary electrophoresis time-of-flight mass spectroscopy (CE-TOFMS) to investigate early effects of MT on the metabolite profiles of the muscle experiencing DOMS. The rats were divided into the following three groups; (1) normal controls, (2) rats with LC application (LC group), and (3) rats undergoing MT after LC (LC + MT group). According to the CE-TOFMS analysis, a total of 171 metabolites were detected among the three groups, and 19 of these metabolites were significant among the groups. Furthermore, the concentrations of eight metabolites, including branched-chain amino acids, carnitine, and malic acid, were significantly different between the LC + MT and LC groups. The results suggest that MT significantly altered metabolite profiles in DOMS. According to our findings and previous data regarding metabolites in mitochondrial metabolism, the ameliorative effects of MT might be mediated partly through alterations in metabolites associated with mitochondrial respiration.

  9. Submaximal delayed-onset muscle soreness: correlations between MR imaging findings and clinical measures

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    Evans, G. F.; Haller, R. G.; Wyrick, P. S.; Parkey, R. W.; Fleckenstein, J. L.; Blomqvist, C. G. (Principal Investigator)

    1998-01-01

    PURPOSE: To assess correlations between muscle edema on magnetic resonance (MR) images and clinical indexes of muscle injury in delayed-onset muscle soreness (DOMS) produced by submaximal exercise protocols. MATERIALS AND METHODS: Sixteen subjects performed 36 elbow flexions ("biceps curls") at one of two submaximal workloads that emphasized eccentric contractions. Changes in MR imaging findings, plasma levels of creatine kinase, and pain scores were correlated. RESULTS: Both exercise protocols produced DOMS in all subjects. The best correlation was between change in creatine kinase level and volume of muscle edema on MR images, regardless of the workload. Correlations tended to be better with the easier exercise protocol. CONCLUSION: Whereas many previous studies of DOMS focused on intense exercise protocols to ensure positive results, the present investigation showed that submaximal workloads are adequate to produce DOMS and that correlations between conventionally measured indexes of injury may be enhanced at lighter exercise intensities.

  10. Massage Alleviates Delayed Onset Muscle Soreness after Strenuous Exercise: A Systematic Review and Meta-Analysis

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    Jianmin Guo

    2017-09-01

    Full Text Available Purpose: The purpose of this systematic review and meta-analysis was to evaluate the effects of massage on alleviating delayed onset of muscle soreness (DOMS and muscle performance after strenuous exercise.Method: Seven databases consisting of PubMed, Embase, EBSCO, Cochrane Library, Web of Science, CNKI and Wanfang were searched up to December 2016. Randomized controlled trials (RCTs were eligible and the outcomes of muscle soreness, performance (including muscle maximal isometric force (MIF and peak torque and creatine kinase (CK were used to assess the effectiveness of massage intervention on DOMS.Results: Eleven articles with a total of 23 data points (involving 504 participants satisfied the inclusion criteria and were pooled in the meta-analysis. The findings demonstrated that muscle soreness rating decreased significantly when the participants received massage intervention compared with no intervention at 24 h (SMD: –0.61, 95% CI: –1.17 to –0.05, P = 0.03, 48 h (SMD: –1.51, 95% CI: –2.24 to –0.77, P < 0.001, 72 h (SMD: –1.46, 95% CI: –2.59 to –0.33, P = 0.01 and in total (SMD: –1.16, 95% CI: –1.60 to –0.72, P < 0.001 after intense exercise. Additionally, massage therapy improved MIF (SMD: 0.56, 95% CI: 0.21–0.90, P = 0.002 and peak torque (SMD: 0.38, 95% CI: 0.04–0.71, P = 0.03 as total effects. Furthermore, the serum CK level was reduced when participants received massage intervention (SMD: –0.64, 95% CI: –1.04 to –0.25, P = 0.001.Conclusion: The current evidence suggests that massage therapy after strenuous exercise could be effective for alleviating DOMS and improving muscle performance.

  11. Effects of therapeutic massage on gait and pain after delayed onset muscle soreness.

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    Han, Jun-Ho; Kim, Min-Jeong; Yang, Hyuk-Jin; Lee, Yu-Jin; Sung, Yun-Hee

    2014-04-01

    Unfamiliar or sudden exercise can induce delayed onset muscle soreness (DOMS) within 12-24 h. So, several researchers have reported various interventions to treat DOMS. Massage is generally known to eliminate muscle fatigue. However, effect of massage after DOMS is still not clear. We investigated whether the massage is effective on pain and gait after DOMS. The participants were divided into a control group (n= 10) with DOMS and an experimental group (n= 11) with the massage treated after DOMS. We induced DOMS by taking isotonic exercise with going up and down 20 times in 5-story building. We applied the massage and assessment on gastrocnemius of dominant foot. The change of gait and pain was assessed using gaitrite and algometer. In the present results, the massage on gastrocnemius after DOMS showed significant difference in pain (P< 0.05). Also, there was a significant difference in gait (P< 0.05), especially, spatial parameters (distance, step length, stride length) and temporal parameters (ambulation, heel on off time, stride velocity). Moreover, the pain relief after massage-treated in DOMS correlated with gait. These results suggest that the massage on gastrocnemius after DOMS has influence on pain and gait performance. Therefore, massage can be applied as intervention for delayed onset muscle soreness.

  12. Relationship between physical exercise, muscle damage and delayed-onset muscle soreness

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    Denis Foschini

    2007-03-01

    Full Text Available The objective of the present study was to investigate the relationship between physical exercise involving muscle damage and delayed-onset muscle soreness (DOMS. A literature review of national and international periodicals was carried out. Muscle structures (membranes, Z-line, sarcomeres, T tubules and myofi brils can become damaged as a result of an imposed mechanical overload. Of greatest note are exercises requiring strength, particularly when muscular action is eccentric. Damage to skeletal musculature can be analyzed by direct methods (muscle biopsy or magnetic resonance or by indirect methods (maximum voluntary movement, subjective pain perception scales, analysis of enzyme and protein concentrations in blood. Creatine kinase (CK, lactate dehydrogenase (LDH, myosin heavy chain fragments, troponin-I and myoglobin can be used as indirect markers of muscle damage. Both DOMS and muscle damage can be infl uenced by the type of activity, with emphasis on eccentric muscle movements, type of exercise, velocity of the movement, interval period between series, the level of individual fi tness, this last primarily affecting beginners. When myotrauma occurs, muscle damage repair is initiated by leukocytes migrating to the injured area, although, the histamines, prostaglandins, kinins and K+ produced by neutrophils and macrophages stimulate free nerve endings in the muscle, causing the DOMS. Despite this apparent relationship between muscle damage and DOMS, it is not possible toestablish a linear relationship between these two variables, since published data are divergent. RESUMO O objetivo desse estudo foi investigar as relações do exercício físico com o dano muscular e dor muscular de início tardio (DMIT. Para tanto, foi realizada uma revisão de literatura de periódicos nacionais e internacionais. O dano muscular pode ocorrer em estruturas musculares (membranas, linha Z, sarcolema, túbulos T e miofi brilas em função da sobrecarga mec

  13. Effects of Inter-electrode Distance on Delayed Onset Muscle Soreness in Microcurrent Therapy.

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    Lee, Jeong-Woo; Kang, Ji-Sun; Park, Soo-Ji; Yoon, Se-Won; Jeong, Seong-Kwan; Heo, Myoung

    2013-11-01

    [Purpose] This study examined the effect of the distance between the two electrodes on delayed onset muscle soreness during microcurrent therapy. [Methods] In this study 24 healthy women who hadn't exercised regularly for six months were selected and randomly divided into two groups. Delayed onset muscle soreness (DOMS) was induced and experimental Group 1 were given microcurrent treatment with the electrodes attached at a close distance evaluated. Experimental Group 2 received the same treatment with the electrodes attached at a greater distance apart. Visual analogue scale pain and the RIII reflex were evaluated after inducing DOMS and after one day, two days, three days and four days of microcurrent treatment. [Results] The visual analogue scale and amplitude of RIII amplitude only showed significant differences with the length of time of the treatment. [Conclusion] This study found that difference of interelectrode distance has no influence on VAS pain and the RIII reflex of DOMS. Although there were no significant differences in RIII amplitude, we suspect that it may be influenced by current parameters such as frequency and intensity.

  14. The Use of Thermal Infra-Red Imaging to Detect Delayed Onset Muscle Soreness

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    Al-Nakhli, Hani H.; Petrofsky, Jerrold S.; Laymon, Michael S.; Berk, Lee S.

    2012-01-01

    Delayed onset muscle soreness (DOMS), also known as exercise induced muscle damage (EIMD), is commonly experienced in individuals who have been physically inactive for prolonged periods of time, and begin with an unexpected bout of exercise1-4, but can also occur in athletes who exercise beyond their normal limits of training5. The symptoms associated with this painful phenomenon can range from slight muscle tenderness, to severe debilitating pain1,3,5. The intensity of these symptoms and the related discomfort increases within the first 24 hours following the termination of the exercise, and peaks between 24 to 72 hours post exercise1,3. For this reason, DOMS is one of the most common recurrent forms of sports injury that can affect an individual’s performance, and become intimidating for many1,4. For the last 3 decades, the DOMS phenomenon has gained a considerable amount of interest amongst researchers and specialists in exercise physiology, sports, and rehabilitation fields6. There has been a variety of published studies investigating this painful occurrence in regards to its underlying mechanisms, treatment interventions, and preventive strategies1-5,7-12. However, it is evident from the literature that DOMS is not an easy pathology to quantify, as there is a wide amount of variability between the measurement tools and methods used to quantify this condition6. It is obvious that no agreement has been made on one best evaluation measure for DOMS, which makes it difficult to verify whether a specific intervention really helps in decreasing the symptoms associated with this type of soreness or not. Thus, DOMS can be seen as somewhat ambiguous, because many studies depend on measuring soreness using a visual analog scale (VAS)10,13-15, which is a subjective rather than an objective measure. Even though needle biopsies of the muscle, and blood levels of myofibre proteins might be considered a gold standard to some6, large variations in some of these blood

  15. Effects of tender point acupuncture on delayed onset muscle soreness (DOMS – a pragmatic trial

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    Kitakoji Hiroshi

    2008-11-01

    Full Text Available Abstract Background Acupuncture is used to reduce inflammation and decrease pain in delayed onset muscle soreness (DOMS. This study investigates the efficacy of acupuncture on the symptoms of DOMS. Methods Thirty subjects were assigned randomly to there groups, namely the control, non-tender point and tender point groups. Measurement of pain with full elbow flexion was used as indices of efficacy. Measurements were taken before and after exercise, immediately after treatment and seven days after treatment. Results Significant differences in visual analog scores for pain were found between the control group and tender point group immediately after treatment and three days after exercise (P Conclusion The results show that tender point acupuncture relieves muscle pain of DOMS.

  16. Effects of vibratory stimulations on maximal voluntary isometric contraction from delayed onset muscle soreness.

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    Koh, Hyung-Woo; Cho, Sung-Hyoun; Kim, Cheol-Yong; Cho, Byung-Jun; Kim, Jin-Woo; Bo, Kak Hwang

    2013-09-01

    [Purpose] The aim of this study was to investigate the effect of vibratory stimulation on maximal voluntary isometric contraction (MVIC) from delayed onset muscle soreness (DOMS). [Subjects] Sixty healthy adults participated in this study. The exclusion criteria were orthopedic or neurologic disease. [Methods] The researchers induced DOMS in the musculus extensor carpi radialis longus of each participant. Subjects in the control group received no treatment. The ultrasound group received ultrasound treatment (intensity, 1.0 W/cm(2;) frequency 1 MHz; time, 10 minutes). The vibration group received vibration stimulation (frequency, 20 MHz; time, 10 minutes). Maximal voluntary isometric contraction (MVIC) was recorded at baseline, immediately after exercise, and 24, 48, and 72 hours after exercise. [Results] MVIC measurements showed statistically significant differences in the vibration group compared with the control group. [Conclusion] Vibratory stimulation had a positive effect on recovery of muscle function from DOMS.

  17. Effects of tender point acupuncture on delayed onset muscle soreness (DOMS) – a pragmatic trial

    Science.gov (United States)

    Itoh, Kazunori; Ochi, Hideki; Kitakoji, Hiroshi

    2008-01-01

    Background Acupuncture is used to reduce inflammation and decrease pain in delayed onset muscle soreness (DOMS). This study investigates the efficacy of acupuncture on the symptoms of DOMS. Methods Thirty subjects were assigned randomly to there groups, namely the control, non-tender point and tender point groups. Measurement of pain with full elbow flexion was used as indices of efficacy. Measurements were taken before and after exercise, immediately after treatment and seven days after treatment. Results Significant differences in visual analog scores for pain were found between the control group and tender point group immediately after treatment and three days after exercise (P < 0.05, Dunnetts multiple test). Conclusion The results show that tender point acupuncture relieves muscle pain of DOMS. PMID:19032777

  18. EFFECTS OF MESSAGE VS ACTIVE EXERCISES ON EXPERIMENTALLY INDUCED DELAYED ONSET OF MUSCLE SORENESS

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    A. Chaturvedi Pilladi *,

    2013-12-01

    Full Text Available Background:To evaluate the effect of massage of versus active exercises on experimentally induced delayedonset of muscle soreness.Method:30 subjects were divided into two groups, Experimental group received Massage and control groupreceived active exercises, results were taken by measurement of pain and functional stair climbing capacity ofknee joint were taken by visual analog score and functional knee rating score.Results:obtained results were analyzed with the use of Paired T-test, which has been carried out to observethetreatment impact between the groups before and after the treatment. After a 4 week treatment period,thesubjects in the Group I (Quadriceps message compared with the subjects in the Group II (Active exercise hadshown a statistically significant improvement with the outcome measures at 0.05 level.Conclusion:Quadriceps massagewas found much effective in decreasing Delayed onset of muscle sorenessthan active exercises.

  19. Whole-Body Vibration While Squatting and Delayed-Onset Muscle Soreness in Women.

    Science.gov (United States)

    Dabbs, Nicole C; Black, Christopher D; Garner, John

    2015-12-01

    Research into alleviating muscle pain and symptoms in individuals after delayed-onset muscle soreness (DOMS) has been inconsistent and unsuccessful in demonstrating a useful recovery modality. To investigate the effects of short-term whole-body vibration (WBV) on DOMS over a 72-hour period after a high-intensity exercise protocol. Randomized controlled clinical trial. University laboratory. Thirty women volunteered to participate in 4 testing sessions and were assigned randomly to a WBV group (n = 16; age = 21.0 ± 1.9 years, height = 164.86 ± 6.73 cm, mass = 58.58 ± 9.32 kg) or a control group (n = 14; age = 22.00 ± 1.97 years, height = 166.65 ± 8.04 cm, mass = 58.69 ± 12.92 kg). Participants performed 4 sets to failure of single-legged split squats with 40% of their body weight to induce muscle soreness in the quadriceps. The WBV or control treatment was administered each day after DOMS. Unilateral pressure-pain threshold (PPT), range of motion (ROM), thigh circumference, and muscle-pain ratings of the quadriceps were collected before and for 3 days after high-intensity exercise. Each day, we collected 3 sets of measures, consisting of 1 measure before the WBV or control treatment protocol (pretreatment) and 2 sets of posttreatment measures. We observed no interactions for PPT, thigh circumference, and muscle pain (P > .05). An interaction was found for active ROM (P = .01), with the baseline pretreatment measure greater than the measures at baseline posttreatment 1 through 48 hours posttreatment 2 in the WBV group. For PPT, a main effect for time was revealed (P .05). The WBV treatment approach studied did not aid in alleviating DOMS after high-intensity exercise. Further research is needed in various populations.

  20. Effect of Vibration in Prevention of Delayed Onset Muscle Soreness: A Recent Update

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    Zubia Veqar

    2012-12-01

    Full Text Available Delayed onset muscle soreness (DOMS is muscular pain and discomfort experienced approximately 24-72 hours after exercise. DOMS is due to microscopic muscle fiber tears and is more common after unfamiliar high-force muscular work. It is seen predominantly post eccentric exercise. It is commonly seen after the intensity and volume of training are increased, the order of progression in exercise or a new training regime is performed. DOMS is not a disorder or disease; it can be considered as a painful type I muscle strain injury. DOMS can limit further exercise in the days following an initial training. It is a matter of concern for coaches, athletic trainers, physiotherapist, and other sports medicine personnel concerned with the athletes. Various pre- and post exercise interventions have been investigated with respect to preventing the subsequent symptoms and treating DOMS. Interventions like pharmacological treatments, therapeutic treatments using physical modalities, and interventions using nutritional supplements have been researched. In the aspect of prevention and treatment of DOMS vibration therapy is effective. Vibration therapy helps to synchronization of motor unit activity by preventing sarcoma disruption and also improves muscular strength, power development and kinesthetic awareness. Thus optimal muscle performance prevents the muscle damage, reducing the chances of DOMS. The purpose of this review is to find out the role of Vibration therapy in preventing DOMS.

  1. Whole-Body Vibration and the Prevention and Treatment of Delayed-Onset Muscle Soreness

    Science.gov (United States)

    Aminian-Far, Atefeh; Hadian, Mohammad-Reza; Olyaei, Gholamreza; Talebian, Saeed; Bakhtiary, Amir Hoshang

    2011-01-01

    Abstract Context: Numerous recovery strategies have been used in an attempt to minimize the symptoms of delayed-onset muscle soreness (DOMS). Whole-body vibration (WBV) has been suggested as a viable warm-up for athletes. However, scientific evidence to support the protective effects of WBV training (WBVT) on muscle damage is lacking. Objective: To investigate the acute effect of WBVT applied before eccentric exercise in the prevention of DOMS. Design: Randomized controlled trial. Setting: University laboratory. Patients or Other Participants: A total of 32 healthy, untrained volunteers were randomly assigned to either the WBVT (n  =  15) or control (n  =  17) group. Intervention(s): Volunteers performed 6 sets of 10 maximal isokinetic (60°/s) eccentric contractions of the dominant-limb knee extensors on a dynamometer. In the WBVT group, the training was applied using a vibratory platform (35 Hz, 5 mm peak to peak) with 100° of knee flexion for 60 seconds before eccentric exercise. No vibration was applied in the control group. Main Outcome Measure(s): Muscle soreness, thigh circumference, and pressure pain threshold were recorded at baseline and at 1, 2, 3, 4, 7, and 14 days postexercise. Maximal voluntary isometric and isokinetic knee extensor strength were assessed at baseline, immediately after exercise, and at 1, 2, 7, and 14 days postexercise. Serum creatine kinase was measured at baseline and at 1, 2, and 7 days postexercise. Results: The WBVT group showed a reduction in DOMS symptoms in the form of less maximal isometric and isokinetic voluntary strength loss, lower creatine kinase levels, and less pressure pain threshold and muscle soreness (P < .05) compared with the control group. However, no effect on thigh circumference was evident (P < .05). Conclusions: Administered before eccentric exercise, WBVT may reduce DOMS via muscle function improvement. Further investigation should be undertaken to ascertain the effectiveness of WBVT in

  2. Does post-exercise massage treatment reduce delayed onset muscle soreness? A systematic review

    Science.gov (United States)

    Ernst, E.

    1998-01-01

    BACKGROUND: Delayed onset muscle soreness (DOMS) is a frequent problem after unaccustomed exercise. No universally accepted treatment exists. Massage therapy is often recommended for this condition but uncertainty exists about its effectiveness. AIM: To determine whether post-exercise massage alleviates the symptoms of DOMS after a bout of strenuous exercise. METHOD: Various computerised literature searches were carried out and located seven controlled trials. RESULTS: Most of the trials were burdened with serious methodological flaws, and their results are far from uniform. However, most suggest that post-exercise massage may alleviate symptoms of DOMS. CONCLUSIONS: Massage therapy may be a promising treatment for DOMS. Definitive studies are warranted. 


 PMID:9773168

  3. Effect of Microcurrent Stimulation on Delayed-Onset Muscle Soreness: A Double-Blind Comparison

    Science.gov (United States)

    Allen, Jennifer D.; Mattacola, Carl G.; Perrin, David H.

    1999-01-01

    Objective: To examine the efficacy of microcurrent electrical neuromuscular stimulation (MENS) treatment on pain and loss of range of motion (ROM) associated with delayed-onset muscle soreness (DOMS). Design and Setting: We assigned subjects to 1 of 2 groups. Group 1 received treatment with microcurrent stimulation (200 μA, 30 Hz, for 10 minutes, then 100 μA, 0.3 Hz, for 10 minutes) 24, 48, and 72 hours after DOMS induction. Group 2 served as a sham group and was treated using a machine altered by the manufacturer so that no current could flow through the electrodes. Subjects: DOMS was induced in the biceps brachii of the nondominant arm of 18 subjects (3 males, 15 females: age = 20.33 ± 2.3 years, ht = 170.81 ± 7.3 cm, wt = 69.61 ± 13.1 kg). Dominance was defined as the arm used by the subject to throw a ball. Measurements: Subjective pain and active elbow extension ROM were evaluated before and after treatment each day. Two methods were used to assess pain: constant pressure using a weighted Orthoplast sphere and full elbow extension to the limit of pain tolerance. Subjective pain was measured with a graphic rating scale and active elbow extension ROM using a standard, plastic, double-armed goniometer. Three repeated-measures ANOVAs (between-subjects variable was group, within- subjects variables were day and test) were used to assess ROM and pain scores for the 2 groups. Results: We found no significant difference in the measurement of subjective pain scores or elbow extension ROM when the MENS group was compared with the sham group. Conclusions: Our results indicate that the MENS treatment, within the parameters used for this experiment, was not effective in reducing the pain or loss of ROM associated with delayed-onset muscle soreness. PMID:16558582

  4. Quantifying delayed-onset muscle soreness: a comparison of unidimensional and multidimensional instrumentation.

    Science.gov (United States)

    Cleather, Daniel J; Guthrie, Sharon R

    2007-06-01

    Unidimensional pain instrumentation, whereby participants simply rate the intensity of their pain on one evaluative level, has been the most common method of assessing delayed-onset muscle soreness (DOMS). However, pain has been shown to be a multidimensional phenomenon including sensory, affective, and evaluative aspects. The aims of this study were two-fold: (1) to compare the DOMS pain responses derived from a multidimensional instrument (i.e. the McGill Pain Questionnaire--MPQ) with those using a unidimensional measure (i.e. a visual analogue scale), and (2) to identify the MPQ descriptors most commonly used to characterize DOMS among a sample of 14 male (mean age = 24.7 years, s = 4.4) and 9 female participants (mean age = 24.6 years, s = 3.5). Although the results demonstrated no significant differences between the pain ratings of the two instruments (mean values of the pain rating indices had a Spearman rank correlation coefficient of r = 1.00), suggesting no significant advantage to be gained in using the MPQ, a clearer description of DOMS emerged. The most frequently selected DOMS descriptors were "tight" (95% of participants chose this descriptor at least once), "sore" (86%), "tender" (86%), "annoying" (86%), and "pulling" (68%). These findings may be of use to researchers and sports medicine professionals in their deliberations about which instrumentation to use in quantifying DOMS and in distinguishing such pain from other, potentially more serious, musculoskeletal damage.

  5. Delayed onset muscle soreness and perceived exertion following blood flow restriction exercise.

    Science.gov (United States)

    Brandner, Christopher R; Warmington, Stuart A

    2017-01-11

    The purpose of this study was to determine the perceptual responses to resistance exercise with either heavy-loads (80% 1 repetition maximum [1-RM]), light-loads (20% 1-RM), or light-loads in combination with blood flow restriction (BFR). Despite the use of light-loads, it has been suggested that the adoption of BFR resistance exercise may be limited due to increases in delayed onset muscle soreness (DOMS) and perceived exertion. Seventeen healthy untrained males participated in this balanced, randomized cross-over study. Following four sets of elbow-flexion exercise, participants reported ratings of perceived exertion (RPE), with DOMS also recorded for seven days following each trial. DOMS was significantly greater for low-pressure continuous BFR (until 48 h post-exercise) and high-pressure intermittent BFR (until 72 h post-exercise) compared with traditional heavy-load and light-load resistance exercise. In addition, RPE was higher for heavy-load resistance exercise and high-pressure intermittent BFR compared with low-pressure continuous BFR, with all trials greater than light-load resistance exercise. For practitioners working with untrained participants, this study provides evidence to suggest that in order to minimize the perception of effort and post-exercise muscle soreness associated with BFR resistance exercise, continuous low-pressure application may be more preferential compared with intermittent high-pressure application. Importantly, these perceptual responses are relatively short-lived (∼2 days) and have previously been shown to subside after a few exercise sessions. Combined with smaller initial training volumes (set x repetitions) this may limit RPE and DOMS to strengthen uptake and adherence, and assist in program progression for muscle hypertrophy and gains in strength.

  6. Central projection of pain arising from delayed onset muscle soreness (DOMS in human subjects.

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    Katharina Zimmermann

    Full Text Available Delayed onset muscle soreness (DOMS is a subacute pain state arising 24-48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1 cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2 areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not.

  7. Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects

    Science.gov (United States)

    Zimmermann, Katharina; Leidl, Caroline; Kaschka, Miriam; Carr, Richard W.; Terekhin, Pavel; Handwerker, Hermann O.; Forster, Clemens

    2012-01-01

    Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24–48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1) cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2) areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not. PMID:23056613

  8. The Effects of High-Volt Pulsed Current Electrical Stimulation on Delayed-Onset Muscle Soreness

    Science.gov (United States)

    Butterfield, David Lynn; Draper, David O.; Ricard, Mark D.; Myrer, J. William; Schulthies, Shane S.; Durrant, Earlene

    1997-01-01

    Objective: We investigated three 30-minute high-volt pulsed current electrical stimulation (HVPC) treatments of 125 pps to reduce pain, restore range of motion (ROM), and recover strength loss associated with delayed-onset muscle soreness (DOMS). Design and Setting: Randomized, masked comparison of three 30-minute treatment and sham HVPC regimens over a 48-hour period. Subjects: Twenty-eight college students. Measurements: Subjects performed concentric and eccentric knee extensions with the right leg to induce muscle soreness. Assessments were made before and after the exercise bout and each treatment at 24, 48, and 72 hours postexercise. Results: Three separate 2 × 3 × 2 ANOVAs were used to determine significant differences (p < .05) between days, treatments, and pre-post treatment effects and significant interaction among these variables. Scheffe post hoc tests showed no significant reduction in pain perception or improvement in loss of function at 24, 48, and 72 hours postexercise. Mean pain perception assessments (0 = no pain, 10 = severe pain) for the HVPC group were 2.9, 4.5, and 3.5 and for the sham group 3.8, 4.8, and 3.5). Mean ROM losses for the HVPC group were 9.0°, 22.3°, and 26.2°, and for the sham group were 9.5°, 23.1°, and 23.0°. Mean strength losses (1RM) for the HVPC group were 25.9, 25.7, and 20.8 lbs and for the sham group were 22.3, 22.3, and 13.8 lbs. Conclusions: HVPC as we studied it was ineffective in providing lasting pain reduction and at reducing ROM and strength losses associated with DOMS. PMID:16558426

  9. EFFECT OF ICE BAG, DYNAMIC STRETCHING AND COMBINED TREATMENTS ON THE PREVENTION AND TREATMENT OF DELAY ONSET MUSCLE SORENESS

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    Warin Krityakiarana; Jariya Budworn; Chatchawan Khajohnanan; Nutchanad Suramas; Watcharaporn Puritasang

    2014-01-01

    Objective: To investigate the effects of ice bag, dynamic stretching, combined ice and dynamic stretching, and control (non-treated) on the prevention and treatment of delayed onset muscle soreness (DOMS) in biceps muscle. Subjects: Fifty-five participants (aged 18 to 25 years) were engaged in this study and randomly assigned into four groups (control group (non-treated) (CG), n = 13; ice bag, n = 14; dynamic stretching, n = 14; and combined treatment, n = 14). Method: Before inducing D...

  10. Effects of cryotherapy on muscle damage markers and perception of delayed onset muscle soreness after downhill running: A Pilot study

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    M. Rossato

    2015-06-01

    Conclusion: Use of cryotherapy after exercise with eccentric contractions was effective to reestablish the level of biochemical markers of muscle damage and reduce muscle soreness and pain perception in subjects submitted to downhill running.

  11. Sports Mass Age Therapy on the Reduction of Delayed Onset Muscle Soreness of the Quadriceps Femoris

    Directory of Open Access Journals (Sweden)

    Boguszewski Dariusz

    2014-12-01

    Full Text Available Purpose. Massage therapy is one of most commonly applied treatments during athletic training. The aim of this study was to assess the effectiveness of sports massage therapy on reducing post-exercise quadriceps muscle soreness. Methods. A sample of 29 women aged 24-26 years was divided into an experimental group (n = 15 receiving classic sports massage therapy and a control group (n = 14 given no treatment. An exercise session consisting of five sets of deep squat jumps was administered after which lower limb power as assessed via the vertical jump test. Muscle soreness was assessed using the visual analogue scale (VAS and exercise intensity with the Borg Rating of Perceived Exertion Scale. Subsequent measurements of lower limb power and muscle soreness were performed 24, 48, 72 and 96 h after the exercise session. Differences between the measurements were assessed by the Friedman and least significant difference tests while between-group comparisons involved the Mann-Whitney U test. Results. The largest decrease in lower limb power was observed between the first measurement after the exercise session and 24 h later (p < 0.01. The smallest decrease in power was observed in the massage group. The highest levels of muscle soreness were noted 24 h post-exercise in the massage group and 48 h post-exercise in the control group. The experimental group showed a decrease in muscle soreness in each subsequent measurement, with the results close to zero on the VAS 96 h postexercise. Conclusions. Massage therapy quickened recovery and improved muscle efficiency post-exercise and may serve as an effective treatment of muscle soreness. The analgesic effect of massage suggests it should be widely applied in sport, physical therapy and rehabilitation.

  12. Various Treatment Techniques on Signs and Symptoms of Delayed Onset Muscle Soreness

    Science.gov (United States)

    Gulick, Dawn T.; Kimura, Iris F.; Sitler, Michael; Paolone, Albert; Kelly, John D.

    1996-01-01

    Eccentric activities are an important component of physical conditioning and everyday activities. Delayed onset muscle soreness (DOMS) can result from strenuous eccentric tasks and can be a limiting factor in motor performance for several days after exercise. An efficacious method of treatment for DOMS would enhance athletic performance and hasten the return to activities of daily living. The purpose of this study was to identify a treatment method which could assist in the recovery of DOMS. In the selection of treatment methods, emphasis was directed toward treatments that could be rendered independently by an individual, therefore making the treatment valuable to an athletic trainer in team setting. DOMS was induced in 70 untrained volunteers via 15 sets of 15 eccentric contractions of the forearm extensor muscles on a Lido isokinetic dynamometer. All subjects performed a pilot exercise bout for a minimum of 9 weeks before data collection to assure that DOMS would be produced. Data were collected on 15 dependent variables: active and passive wrist flexion and extension, forearm girth, limb volume, visual analogue pain scale, muscle soreness index, isometric strength, concentric and eccentric wrist total work, concentric and eccentric angle of peak torque. Data were collected on six occasions: pre- and post-induced DOMS, 20 minutes after treatment, and 24, 48, and 72 hours after treatment. Subjects were randomly assigned to 1 of 7 groups (6 treatment and 1 control). Treatments included a nonsteroidal anti-inflammatory drug, high velocity concentric muscle contractions on an upper extremity ergometer, ice massage, 10-minute static stretching, topical Amica montana ointment, and sublingual A. montana pellets. A 7 × 6 ANOVA with repeated measures on time was performed on the delta values of each of the 15 dependent variables. Significant main effects (p < .05) were found for all of the dependent variables on time only. There were no significant differences between

  13. Influence of vibration on delayed onset of muscle soreness following eccentric exercise

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    Bakhtiary, Amir H; Safavi‐Farokhi, Ziaeddin; Aminian‐Far, Atefeh

    2007-01-01

    Delayed onset muscle soreness (DOMS), which may occur after eccentric exercise, may cause some reduction in ability in sport activities. For this reason, several studies have been designed on preventing and controlling DOMS. As vibration training (VT) may improve muscle performance, we designed this study to investigate the effect of VT on controlling and preventing DOMS after eccentric exercise. Methods Fifty healthy non‐athletic volunteers were assigned randomly into two experimental, VT (n = 25) and non‐VT (n = 25) groups. A vibrator was used to apply 50 Hz vibration on the left and right quadriceps, hamstring and calf muscles for 1 min in the VT group, while no vibration was applied in the non‐VT group. Then, both groups walked downhill on a 10° declined treadmill at a speed of 4 km/hour. The measurements included the isometric maximum voluntary contraction force (IMVC) of left and right quadriceps muscles, pressure pain threshold (PPT) 5, 10 and 15 cm above the patella and mid‐line of the calf muscles of both lower limbs before and the day after treadmill walking. After 24 hours, the serum levels of creatine‐kinase (CK), and DOMS level by visual analogue scale were measured. Results The results showed decreased IMVC force (P = 0.006), reduced PPT (P = 0.0001) and significantly increased mean of DOMS and CK levels in the non‐VT group, compared to the VT group (P = 0.001). Conclusion A comparison by experimental groups indicates that VT before eccentric exercise may prevent and control DOMS. Further studies should be undertaken to ascertain the stability and effectiveness of VT in athletics. PMID:17138635

  14. A review of nutritional intervention on delayed onset muscle soreness. Part I.

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    Kim, Jooyoung; Lee, Joohyung

    2014-12-01

    This review is focused on the effect of nutritional intervention on delayed onset muscle soreness (DOMS) that occurs after exercise. In general, high force eccentric contractions and/or unaccustomed exercise result in DOMS attributed to reduction in performance such as muscle strength and range of motion (ROM) for both athletes and non-athletes. Nutritional intervention is one of the preventive or therapeutic ways to reduce DOMS. Previous research studies have suggested the following nutrition intervention: caffeine, omega-3 fatty acids, taurine, polyphenols, and so on. Nutritional intervention with these nutrients before and after exercise was reported to be effective in reducing DOMS. These nutritional interventions have also been reported to affect inflammatory responses and oxidative stress leading to DOMS reduction. However, other studies have reported that these nutritional interventions have no effect on DOMS. It is suggested that intake of proper nutrition intervention can effectively reduce DOMS after exercise and quickly help an athlete return to exercise or training program. In addition, nutritional intervention may help both athletes and non-athletes who engage in physical therapy or rehabilitative programs after surgery or any injurious events.

  15. Pilot Study on the Effect of Grounding on Delayed-Onset Muscle Soreness

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    Brown, Dick; Hill, Michael

    2010-01-01

    Abstract Objectives The purpose of this pilot study was to determine whether there are markers that can be used to study the effects of grounding on delayed-onset muscle soreness (DOMS). Design and subjects Eight (8) healthy subjects were exposed to an eccentric exercise that caused DOMS in gastrocnemius muscles of both legs. Four (4) subjects were grounded with electrode patches and patented conductive sheets connected to the earth. Four (4) control subjects were treated identically, except that the grounding systems were not connected to the earth. Outcome measures Complete blood counts, blood chemistry, enzyme chemistry, serum and saliva cortisols, magnetic resonance imaging and spectroscopy and pain levels were taken at the same time of day before the eccentric exercise and 24, 48, and 72 hours afterwards. Parameters consistently differing by 10% or more, normalized to baseline, were considered worthy of further study. Results Parameters that differed by these criteria included white blood cell counts, bilirubin, creatine kinase, phosphocreatine/inorganic phosphate ratios, glycerolphosphorylcholine, phosphorylcholine, the visual analogue pain scale, and pressure measurements on the right gastrocnemius. Conclusions In a pilot study, grounding the body to the earth alters measures of immune system activity and pain. Since this is the first intervention that appears to speed recovery from DOMS, the pilot provides a basis for a larger study. PMID:20192911

  16. The effects of kinesio taping on architecture, strength and pain of muscles in delayed onset muscle soreness of biceps brachii.

    Science.gov (United States)

    Lee, Yong Sin; Bae, Sea Hyun; Hwang, Jin Ah; Kim, Kyung Yoon

    2015-02-01

    [Purpose] This study aimed to confirm the effects of kinesio taping (KT) on muscle function and pain due to delayed onset muscle soreness (DOMS) of the biceps brachii. [Subjects and Methods] Thirty-seven subjects with induced DOMS were randomized into either Group I (control, n=19) or Group II (KT, n=18). Outcome measures were recorded before the intervention (application of KT) and at 24, 48, and 72 hours after the intervention. DOMS was induced, and muscle thickness was measured using ultrasonic radiography. Maximal voluntary isometric contraction (%MVIC) was measured via electromyography (EMG). Subjective pain was measured using a visual analogue scale (VAS). [Results] Group I exhibited a positive correlation between muscle thickness and elapsed time from intervention (24, 48, and 72 hours post induction of DOMS); they also showed a significant decrease in MVIC(%). Group II showed significant increases in muscle thickness up to the 48-hour interval post induction of DOMS, along with a significant decrease in MVIC (%). However, in contrast to Group I, Group II did not show a significant difference in muscle thickness or MVIC (%) at the 72-hour interval in comparison with the values prior to DOMS induction. [Conclusion] In adults with DOMS, activation of muscles by applying KT was found to be an effective and faster method of recovering muscle strength than rest alone.

  17. TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness.

    Science.gov (United States)

    Ota, Hiroki; Katanosaka, Kimiaki; Murase, Shiori; Kashio, Makiko; Tominaga, Makoto; Mizumura, Kazue

    2013-01-01

    Unaccustomed strenuous exercise that includes lengthening contraction (LC) often causes tenderness and movement related pain after some delay (delayed-onset muscle soreness, DOMS). We previously demonstrated that nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) are up-regulated in exercised muscle through up-regulation of cyclooxygenase (COX)-2, and they sensitized nociceptors resulting in mechanical hyperalgesia. There is also a study showing that transient receptor potential (TRP) ion channels are involved in DOMS. Here we examined whether and how TRPV1 and/or TRPV4 are involved in DOMS. We firstly evaluated a method to measure the mechanical withdrawal threshold of the deep tissues in wild-type (WT) mice with a modified Randall-Selitto apparatus. WT, TRPV1-/- and TRPV4-/- mice were then subjected to LC. Another group of mice received injection of murine NGF-2.5S or GDNF to the lateral gastrocnemius (LGC) muscle. Before and after these treatments the mechanical withdrawal threshold of LGC was evaluated. The change in expression of NGF, GDNF and COX-2 mRNA in the muscle was examined using real-time RT-PCR. In WT mice, mechanical hyperalgesia was observed 6-24 h after LC and 1-24 h after NGF and GDNF injection. LC induced mechanical hyperalgesia neither in TRPV1-/- nor in TRPV4-/- mice. NGF injection induced mechanical hyperalgesia in WT and TRPV4-/- mice but not in TRPV1-/- mice. GDNF injection induced mechanical hyperalgesia in WT but neither in TRPV1-/- nor in TRPV4-/- mice. Expression of NGF and COX-2 mRNA was significantly increased 3 h after LC in all genotypes. However, GDNF mRNA did not increase in TRPV4-/- mice. These results suggest that TRPV1 contributes to DOMS downstream (possibly at nociceptors) of NGF and GDNF, while TRPV4 is located downstream of GDNF and possibly also in the process of GDNF up-regulation.

  18. Myocellular enzyme leakage, polymorphonuclear neutrophil activation and delayed onset muscle soreness induced by isokinetic eccentric exercise.

    Science.gov (United States)

    Croisier, J L; Camus, G; Deby-Dupont, G; Bertrand, F; Lhermerout, C; Crielaard, J M; Juchmès-Ferir, A; Deby, C; Albert, A; Lamy, M

    1996-01-01

    To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product prostaglandin E2 (PGE2). 10 healthy male subjects were submitted to eccentric and concentric isokinetic exercises on a Kin Trex device at 60 degrees/s angular velocity. Exercise consisted of 8 stages of 5 maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases. There was an interval of at least 30 days between eccentric and concentric testing, and the order of the two exercise sessions was randomly assigned. The subjective presence and intensity of DOMS was evaluated using a visual analogue scale, immediately, following 24 h and 48 h after each test. Five blood samples were drawn from an antecubital vein: at rest before exercise, immediately after, after 30 min recovery, 24 h and 48 h after the tests. The magnitude of the acute inflammatory response to exercise was assessed by measuring plasma levels of polymorphonuclear elastase ([EL]), myeloperoxidase ([MPO]) and PGE2 ([PGE2]). Using two way analysis of variance, it appeared that only eccentric exercise significantly increased [EL] and DOMS, especially of the hamstring muscles. Furthermore, a significant decrease in eccentric peak torque of this muscle group only was observed on day 2 after eccentric work (- 21%; P < 0.002). Serum activity of creatine kinase and serum concentration of myoglobin increased significantly 24 and 48 h after both exercise tests. However, these variables reached significantly higher values following eccentric contractions 48 h after exercise. Mean [PGE2] in the two exercise modes remained unchanged over time and were practically equal at each time point. On the basis of these findings, we conclude that the magnitude of polymorphonuclear (PMN) activation, muscle damage, and DOMS are greater after eccentric than after concentric muscle

  19. The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS

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    Babak Nakhostin-Roohi

    2016-07-01

    Full Text Available Inflammation and pain induced by delayed onset muscle soreness (DOMS can be induced by eccentric exercise or an unaccustomed activity. The condition can causes problems in exercising and for athletes. The purpose of this study was to assess the effect of 150mg curcumin supplementation immediately after intensive eccentric exercise. Evaluations were made for total antioxidant Capacity (TAC, muscle damage markers, and DOMS induced pain. Ten healthy young males (age, 25.0 ± 1.6 years; height, 178.9 ± 4.1 cm; body mass, 81.1 ± 6.8 kg; fat%, 14.2 ± 2.1 completed a double blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (150mg and a placebo on squat performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin (CU or placebo (P was taken at the prescribed dose immediately after eccentric squat exercises; administrations were separated by a 14-day washout period. Measurements were made at the baseline, immediately, 24, 48, and 72h after exercise comprising: (a limb pain (1–10 cm visual analogue scale; VAS, (b total antioxidant capacity (TAC (c serum markers of muscle damage and inflammation. Measurements taken after exercise showed significantly reduced levels of pain, creatine kinase (CK, alanine aminotransferase (ALT, and aspartate aminotransferase (AST in C group compared with group P group (P<0.05. TAC remained significantly high in group C after exercise compared with levels in group P (P<0.05. The findings of this study suggest that a 150mg dose of curcumin may have antioxidant, anti-inflammatory and analgesic effects on DOMS.

  20. Effects of dietary carbohydrate on delayed onset muscle soreness and reactive oxygen species after contraction induced muscle damage

    Science.gov (United States)

    Close, G; Ashton, T; Cable, T; Doran, D; Noyes, C; McArdle, F; MacLaren, D

    2005-01-01

    Background: Delayed onset muscle soreness (DOMS) occurs after unaccustomed exercise and has been suggested to be attributable to reactive oxygen species (ROS). Previous studies have shown increased ROS after lengthening contractions, attributable to invading phagocytes. Plasma glucose is a vital fuel for phagocytes, therefore carbohydrate (CHO) status before exercise may influence ROS production and DOMS Objective: To examine the effect of pre-exercise CHO status on DOMS, ROS production, and muscle function after contraction induced muscle damage. Method: Twelve subjects performed two downhill runs, one after a high CHO diet and one after a low CHO diet. Blood samples were drawn for analysis of malondialdehyde, total glutathione, creatine kinase, non-esterified fatty acids, lactate, glucose, and leucocytes. DOMS and muscle function were assessed daily. Results: The high CHO diet resulted in higher respiratory exchange ratio and lactate concentrations than the low CHO diet before exercise. The low CHO diet resulted in higher non-esterified fatty acid concentrations before exercise. DOMS developed after exercise and remained for up to 96 hours, after both diets. A biphasic response in creatine kinase occurred after both diets at 24 and 96 hours after exercise. Malondialdehyde had increased 72 hours after exercise after both diets, and muscle function was attenuated up to this time. Conclusions: Downhill running resulted in increased ROS production and ratings of DOMS and secondary increases in muscle damage. CHO status before exercise had no effect. PMID:16306505

  1. Herbs and natural supplements in the prevention and treatment of delayed-onset muscle soreness

    Science.gov (United States)

    Meamarbashi, Abbas

    2017-01-01

    Objective: Unaccustomed and intense eccentric exercise is a common cause of delayed-onset muscle soreness (DOMS). There are multiple remedies for the treatment of DOMS, but its clinical and laboratory pieces of evidence are scarce. Currently, the treatments proposed for DOMS are numerous and include pharmaceuticals, herbal remedies, stretching, massage, nutritional supplements, and other alternatives. To find a holistic treatment with effective pain relief and minimum side effects, complementary and alternative medicine, including herbal therapies, plays a main role. Methods: In this review, the existing published studies investigating the efficacy of herbal and natural supplementation therapies for the prevention or treatment of side effects, symptoms, and signs of DOMS are summarized. Results: Previous studies have documented the efficacy of herbal therapies to treat pain, inflammation, as well as laboratory and clinical side effects of DOMS. Conclusion: The use of herbs in DOMS seems safer and has lower side effects than pharmacotherapy. However, the potential for side effects and drug interactions should be considered. PMID:28265543

  2. Herbs and natural supplements in the prevention and treatment of delayed-onset muscle soreness

    Directory of Open Access Journals (Sweden)

    Abbas Meamarbashi

    2017-01-01

    Full Text Available Objective:  Unaccustomed and intense eccentric exercise is a common cause of delayed-onset muscle soreness (DOMS. There are multiple remedies for the treatment of DOMS, but its clinical and laboratory pieces of evidence are scarce. Currently, the treatments proposed for DOMS are numerous and include pharmaceuticals, herbal remedies, stretching, massage, nutritional supplements, and other alternatives. To find a holistic treatment with effective pain relief and minimum side effects, complementary and alternative medicine, including herbal therapies, plays a main role.Methods: In this review, the existing published studies investigating the efficacy of herbal and natural supplementation therapies for the prevention or treatment of side effects, symptoms, and signs of DOMS are summarized.Results: Previous studies have documented the efficacy of herbal therapies to treat pain, inflammation, as well as laboratory and clinical side effects of DOMS.Conclusion: The use of herbs in DOMS seems safer and has lower side effects than pharmacotherapy. However, the potential for side effects and drug interactions should be considered.

  3. Dehydration and Symptoms of Delayed-Onset Muscle Soreness in Normothermic Men

    Science.gov (United States)

    Cleary, Michelle A; Sitler, Michael R; Kendrick, Zebulon V

    2006-01-01

    Context: A dehydrated individual who performs eccentric exercise may exacerbate skeletal muscle damage, leading to structural, contractile, and enzymatic protein denaturation, in addition to the myofiber and connective damage resulting from the eccentric muscle tension. Objective: To identify the effects of dehydration on 5 physiologic characteristics of delayed-onset muscle soreness (DOMS) in normothermic men after an eccentric exercise perturbation. Design: Randomized group test-retest design. Setting: Laboratory. Patients or Other Participants: Ten healthy male volunteers randomly assigned to either a euhydration (age = 26.2 ± 4.9 years, height = 174.1 ± 6.0 cm, mass = 86.5 ± 15.3 kg) or dehydration (age = 25.8 ± 2.2 years, height = 177.2 ± 3.1 cm, mass = 84.4 ± 3.8 kg) group. Intervention(s): Subjects performed treadmill walking for 45 minutes in either a thermoneutral (euhydration) or a hot, humid (dehydration) environment. After a rest period to allow for return to the normothermic condition, DOMS was induced with a 45-minute downhill run. Main Outcome Measures: We assessed 5 physiologic characteristics of DOMS before and at intervals after the eccentric exercise. The characteristics were perceived pain of the bilateral quadriceps and overall body, bilateral punctate tenderness of the superficial quadriceps muscles, bilateral knee-flexion passive range of motion, bilateral thigh circumference, and bilateral isometric quadriceps muscle strength. Thermoregulatory and cardiovascular measures were obtained to monitor participants' heat load during exercise. Results: The experimental protocol produced a 0.9% increase in body mass of the euhydration group and a significant 2.7% decrease in body mass of the dehydration group. The downhill-running exercise perturbation induced DOMS in both the euhydrated and dehydrated participants, based on increased bilateral quadriceps and overall body perceived pain and punctate tenderness of the bilateral vastus medialis

  4. The Effects of Proprioceptive Neuromuscular Facilitation Stretching on Post-Exercise Delayed Onset Muscle Soreness in Young Adults

    OpenAIRE

    McGRATH, RYAN P.; James R. Whitehead; CAINE, DENNIS J.

    2014-01-01

    Until recently, the scientific community believed that post-exercise stretching could reduce delayed onset muscle soreness (DOMS), but recent reviews of studies on the topic have concluded that pre- or post-exercise static stretching has no effect on mitigating DOMS. However, the effect of proprioceptive neuromuscular facilitation (PNF) post-exercise stretching on preventing DOMS has not been adequately studied. The purpose of this study was to determine the effect of post-exercise PNF stretc...

  5. Perceived Muscle Soreness in Recreational Female Runners

    OpenAIRE

    Burnett, D; Smith, K; Smeltzer, C.; Young, K.; Burns, S

    2010-01-01

    The purpose of this study was to determine if rating of perceived exertion correlated with perceived muscle soreness during delayed onset muscle soreness (DOMS) in female runners. This study examined the pre and post running economy measures and perceived muscle soreness before and after a 30-min downhill run (DHR) at −15% grade and 70% of the subjects predetermined maximum oxygen uptake (VO2 peak). Six female recreational runners (mean age = 24.5) performed level running at 65%, 75%, and 85%...

  6. Resveratrol exerts no effect on inflammatory response and delayed onset muscle soreness after a marathon in male athletes.

    Science.gov (United States)

    Laupheimer, M W; Perry, M; Benton, S; Malliaras, P; Maffulli, N

    2014-01-01

    Objective We investigated whether the inflammatory response and delayed onset of muscle soreness after a marathon are altered by resveratrol, a natural polyphenolic flavonoid antioxidant. Design: Double blind placebo-controlled randomised pilot study. Setting: London Marathon. Participants: Marathon race participants Interventions: 7 healthy male athletes were randomised to receive Resveratrol (600 mg Resveratrol daily for 7 days immediately before the marathon) or a placebo. Main Outcome Measurements: Blood samples taken 48 hours before and 18–32 hours after the marathon were analysed for white blood cell count (WBC) and C-reactive protein (CRP). A VAS score was taken at the same times as the blood samples to assess delayed onset muscle soreness. Results: There were no significant differences between the two groups in terms of changes occurring between pre- and post- tests for WBC, CRP or VAS. Conclusions: There were no differences in immune response or delayed onset muscle soreness between resveratrol and placebo after a marathon. Further investigations are needed with longer treatment time and higher doses, analysing additional parameters such interleukins for a possible effect of resveratrol on the inflammatory response due to extensive exercise. To avoid a type II error, 17 subjects in each group would be required. PMID:25147765

  7. [Are antioxidant supplements effective in reducing delayed onset muscle soreness? A systematic review].

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    Candia-Luján, Ramón; De Paz Fernández, José Antonio; Costa Moreira, Osvaldo

    2014-10-05

    Introducción: En los últimos años los suplementos antioxidantes han cobrado popularidad para contrarrestar los efectos de los radicales libres y los síntomas del daño muscular, entre los que se encuentra el dolor muscular tardío (DMT). Objetivo: realizar una revisión sistemática en diferentes bases de datos para conocer los efectos de los suplementos antioxidantes sobre el DMT. Método: Se llevó a cabo una búsqueda en las bases de datos; Cochrane Library, Pubmed, Scopus y SportDiscus y la Web Of Science (WOS). Las palabras y acrónimos usados fueron; Delayed onset muscle soreness, exercise induced muscle damage, DOMS, EIMD, antioxidant y oxidative stress. Resultados: Se identificaron 54 artículos de los cuales se recuperaron 48, todos ellos en inglés, 17 relacionados con la vitamina C y E, catorce corresponden a suplementos polifenòlicos, once a otros suplementos antioxidantes y seis a suplementos comerciales todos ellos usados para combatir, entre otras variables, el DMT. Conclusiones: Tanto las vitaminas como los suplementos comerciales presentan baja efectividad en la disminución del DMT, mientras que los polifenoles y otros suplementos antioxidantes muestran entre moderada y buena efectividad en el combate al DMT. Sin embargo, gran parte de los estudios presentan efectividad en la disminución de otros síntomas del daño muscular además de ayudar en la recuperación postejercicio.

  8. A COMPARISON OF TOPICAL MENTHOL TO ICE ON PAIN, EVOKED TETANIC AND VOLUNTARY FORCE DURING DELAYED ONSET MUSCLE SORENESS

    Science.gov (United States)

    Johar, Pramod; Grover, Varun; Topp, Robert

    2012-01-01

    Purpose/Background: Pain can adversely affect muscle functioning by inhibiting muscle contractions. Delayed onset muscle soreness was used as a tool to ascertain whether a topical menthol-based analgesic or ice was more effective at reducing pain and permitting greater muscular voluntary and evoked force. Methods: Sixteen subjects were randomized to receive either a topical gel containing 3.5% menthol or topical application of ice to the non-dominant elbow flexors two days following the performance of an exercise designed to induce muscle soreness. Two days later, DOMS discomfort was treated with a menthol based analgesic or ice. Maximum voluntary contractions and evoked tetanic contractions of the non-dominant elbow flexors were measured at baseline prior to inducing muscle soreness (T1), two days following inducing DOMS after 20 (T2), 25 (T3) and 35 (T4) minutes of either menthol gel or ice therapy. Pain perception using a 10-point visual analog scale was also measured at these four data collection points. Treatment analysis included a 2 way repeated measures ANOVA (2 × 4). Results: Delayed onset muscle soreness decreased (p = 0.04) voluntary force 17.1% at T2 with no treatment effect. Tetanic force was 116.9% higher (p<0.05) with the topical analgesic than ice. Pain perception at T2 was significantly (p=0.02) less with the topical analgesic versus ice. Conclusions: Compared to ice, the topical menthol-based analgesic decreased perceived discomfort to a greater extent and permitted greater tetanic forces to be produced. Level of Evidence: Level 2b PMID:22666646

  9. Dehydration and Symptoms of Delayed-Onset Muscle Soreness in Hyperthermic Males

    Science.gov (United States)

    Cleary, Michelle A; Sweeney, Lori A; Kendrick, Zebulon V; Sitler, Michael R

    2005-01-01

    Context: Exercise in the heat produces cellular conditions that may leave skeletal muscle susceptible to exercise-induced microdamage. Delayed-onset muscle soreness (DOMS) is a clinical model of contraction-induced skeletal muscle injury. Objective: To determine whether thermoregulation during exercise heat stress adversely affects muscle injury and the accompanying DOMS. Design: Randomized group test-retest design. Setting: Laboratory. Patients or Other Participants: Ten healthy male volunteers were randomly assigned to either the euhydration/hyperthermic or dehydration/hyperthermic group. Intervention(s): Participants were randomly assigned to treadmill walking in a hot, humid environmental chamber (40°C and 75% relative humidity) with either oral rehydration (euhydration/hyperthermic) or fluid restriction (dehydration/hyperthermic). Immediately after heat exposure and while hyperthermic, participants performed an eccentrically biased downhill run to induce DOMS. Main Outcome Measure(s): We measured DOMS characteristics pre-exercise and at 0.5, 24, 48, 72, and 96 hours postexercise. Results: Treadmill exercise and exposure to the hot ambient environment elicited a 0.9% body mass loss for the euhydrated/ hyperthermic (mean rectal temperature after 60 minutes of heat-stress trial = 38.2 ± 0.4°C) and 3.3% body mass loss for the dehydrated/hyperthermic participants (mean rectal temperature after 60 minutes of heat-stress trial = 38.1 ± 0.4°C). Quadriceps perceived pain was significantly higher (F5,40 = 18.717, P ≤ .001) than baseline at 24 and 48 hours postexercise, following the classic pattern of DOMS. Overall lower extremity perceived pain was significantly higher for the dehydration/hyperthermia group than the euhydration/hyperthermia group (F1,8 = 6.713, P = .032). Punctate tenderness of the vastus lateralis for the dehydration/hyperthermic group was 6.9% higher (F5,40 = 4.462, P = .003) than for the euhydration/ hyperthermic group. No clinically

  10. Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run

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    Baum K

    2013-05-01

    Full Text Available Klaus Baum,1 Richard D Telford,2 Ross B Cunningham,3 1Trainingsinstitut Prof Baum, Köln, Germany; 2College of Medicine, Biology, and Environment, Australian National University, Canberra, ACT, Australia; 3The Fenner School of Environment and Society, Australian National University, Canberra, ACT, Australia Objective: Runners are prone to delayed onset muscle soreness (DOMS during long distance training. This especially holds for unaccustomed training volumes at moderate to high intensities. We investigated the effects of a marine oil complex, PCSO-524®, derived from the New Zealand green-lipped mussel (formulated as Lyprinol® and Omega XL® on DOMS after a 30 km training run. Methods: Initially, peak oxygen uptake of 32 distance runners (4 female, 28 male; median age 45 years, range 28–53 was measured on a treadmill with a 1.5 km hour-1 increase every 4 minutes starting from 8.5 km hour-1. At least 1-week after this initial test, they participated in a 30 km road run at a speed corresponding to about 70% of their individual peak oxygen uptake on a flat terrain. Before and after (0, 24, and 48 hours the run, blood concentration of creatine kinase (CK were measured and pain sensation was determined (pain scale from 0 = no pain to 10 = extremely painful. Runners were then matched in pairs based on maximal CK and peak oxygen uptake, and allocated randomly into two different groups. One group was supplemented with 400 mg per day of PCSO-524® for 11 weeks, the other group with an olive oil placebo. After that period, CK and pain sensations were remeasured following a second 30 km run at the same speed and on the same terrain. Results: The general pattern of soreness in the PCSO-524® supplemented group was reduced by 1.1 units (standard error 0.41 compared to the placebo (P < 0.05, the effects being greater in lesser trained runners (P < 0.05. CK levels were positively associated with pain sensation (P < 0.05, but trends toward lower CK in the

  11. TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness.

    Directory of Open Access Journals (Sweden)

    Hiroki Ota

    Full Text Available Unaccustomed strenuous exercise that includes lengthening contraction (LC often causes tenderness and movement related pain after some delay (delayed-onset muscle soreness, DOMS. We previously demonstrated that nerve growth factor (NGF and glial cell line-derived neurotrophic factor (GDNF are up-regulated in exercised muscle through up-regulation of cyclooxygenase (COX-2, and they sensitized nociceptors resulting in mechanical hyperalgesia. There is also a study showing that transient receptor potential (TRP ion channels are involved in DOMS. Here we examined whether and how TRPV1 and/or TRPV4 are involved in DOMS. We firstly evaluated a method to measure the mechanical withdrawal threshold of the deep tissues in wild-type (WT mice with a modified Randall-Selitto apparatus. WT, TRPV1-/- and TRPV4-/- mice were then subjected to LC. Another group of mice received injection of murine NGF-2.5S or GDNF to the lateral gastrocnemius (LGC muscle. Before and after these treatments the mechanical withdrawal threshold of LGC was evaluated. The change in expression of NGF, GDNF and COX-2 mRNA in the muscle was examined using real-time RT-PCR. In WT mice, mechanical hyperalgesia was observed 6-24 h after LC and 1-24 h after NGF and GDNF injection. LC induced mechanical hyperalgesia neither in TRPV1-/- nor in TRPV4-/- mice. NGF injection induced mechanical hyperalgesia in WT and TRPV4-/- mice but not in TRPV1-/- mice. GDNF injection induced mechanical hyperalgesia in WT but neither in TRPV1-/- nor in TRPV4-/- mice. Expression of NGF and COX-2 mRNA was significantly increased 3 h after LC in all genotypes. However, GDNF mRNA did not increase in TRPV4-/- mice. These results suggest that TRPV1 contributes to DOMS downstream (possibly at nociceptors of NGF and GDNF, while TRPV4 is located downstream of GDNF and possibly also in the process of GDNF up-regulation.

  12. Delayed-onset muscle soreness: a pilot study to assess analgesic study design features.

    Science.gov (United States)

    Singla, Neil; Desjardins, Paul J; Cosca, Evelyn B; Parulan, Cherri; Arriaga, Anne; Poole, Kelly C; Batz, Dan M; Chang, Phoebe D

    2015-06-01

    Based on a thorough review of the available literature in the delayed-onset muscle soreness (DOMS) model, we identified multiple study design characteristics that are considered to be normative in acute pain research but have not been followed in a majority of published DOMS experiments. We designed an analgesic investigation using the DOMS model that both complied with current scientifically accepted standards for the conduct of analgesic studies and demonstrated reasonable assay sensitivity. This randomized, double-blind, placebo-controlled within-subject study compared the efficacy of topical diclofenac sodium 1% with a matching placebo in reducing pain associated with DOMS. After exercise, subjects reporting DOMS received topical diclofenac sodium gel 1% (DSG 1%) applied to one leg and placebo to the other every 6 hours for 48 hours. Pain intensity was assessed at rest, upon standing, and when walking in the 48 hours after initial drug application (T0). The primary end point was the reduction in pain intensity (SPID 24) on walking. Subjects receiving DSG 1% had less pain while walking compared with those receiving placebo at 24 hours (SPID 24 = 34.9 [22.9] and 23.6 [19.4], respectively; P = 0.032). This investigation used experimental techniques that have been vetted in the field of exercise physiology and superimposed techniques that are considered to be best practice in the field of analgesic research. Over time and with the help of colleagues in both fields of study, similar investigations will validate design features that impact the assay sensitivity of analgesic end points in DOMS models. In addition, the study confirmed the analgesic efficacy of topical DSG 1% over placebo in subjects experiencing DOMS.

  13. Ice‐water immersion and delayed‐onset muscle soreness: a randomised controlled trial

    Science.gov (United States)

    Sellwood, Kylie Louise; Brukner, Peter; Williams, David; Nicol, Alastair; Hinman, Rana

    2007-01-01

    Objective To determine if ice‐water immersion after eccentric quadriceps exercise minimises the symptoms of delayed‐onset muscle soreness (DOMS). Design A prospective randomised double‐blind controlled trial was undertaken. 40 untrained volunteers performed an eccentric loading protocol with their non‐dominant leg. Interventions Participants were randomised to three 1‐min immersions in either ice water (5±1°C) or tepid water (24°C). Main outcome measures Pain and tenderness (visual analogue scale), swelling (thigh circumference), function (one‐legged hop for distance), maximal isometric strength and serum creatine kinase (CK) recorded at baseline, 24, 48 and 72 h after exercise. Changes in outcome measures over time were compared to determine the effect of group allocation using independent t tests or Mann–Whitney U tests. Results No significant differences were observed between groups with regard to changes in most pain parameters, tenderness, isometric strength, swelling, hop‐for‐distance or serum CK over time. There was a significant difference in pain on sit‐to‐stand at 24 h, with the intervention group demonstrating a greater increase in pain than the control group (median change 8.0 vs 2.0 mm, respectively, p = 0.009). Conclusions The protocol of ice‐water immersion used in this study was ineffectual in minimising markers of DOMS in untrained individuals. This study challenges the wide use of this intervention as a recovery strategy by athletes. PMID:17261562

  14. Temporal Pattern of the Repeated Bout Effect of Eccentric Exercise on Delayed-Onset Muscle Soreness

    Science.gov (United States)

    Cleary, Michelle A.; Kimura, Iris F.; Sitler, Michael R.; Kendrick, Zebulon V.

    2002-01-01

    Objective: To determine the temporal pattern of the repeated bout effect of eccentric exercise on perceived pain and muscular tenderness associated with delayed-onset muscle soreness (DOMS). Design and Setting: Subjects completed 2 identical eccentric exercise bouts separated by 6, 7, 8, or 9 weeks. The experiment was conducted in a biokinetics research laboratory. Subjects: Sixteen male and 15 female untrained subjects (age = 24.59 ± 4.42 years, height = 171.71 ± 7.81 cm, weight = 73.00 ± 11.20 kg). Measurements: Two physiologic characteristics of DOMS were measured immediately before and 0, 24, 48, and 72 hours after each eccentric exercise bout. Perceived pain was measured using a visual analog scale (VAS), and muscular tenderness was measured using a punctate tenderness gauge (PTG). Results: Two 4 × 2 × 5 (group × bout × time) analyses of variance with repeated measures on the bout and time factors were performed on the VAS and PTG data. Significant (P < .05) main effects were found for group, bout, and time for the VAS and the PTG data. No significant interactions were detected. Post hoc analysis revealed significantly less perceived pain for the 9-week group than the 8-week group. The 7-week group had significantly less and the 8-week group had significantly more muscular tenderness than any other group. Perceived pain and muscular tenderness were significantly less after exercise bout 2 than after exercise bout 1. All subjects had significantly less perceived pain and muscular tenderness pre-exercise than 0 and 24 hours after the eccentric exercise bouts. Conclusions: An effective prophylaxis for perceived pain and muscular tenderness associated with DOMS is the performance of an eccentric exercise bout 6 to 9 weeks before a similar exercise bout. PMID:12937441

  15. Hyperbaric oxygen therapy for delayed onset muscle soreness and closed soft tissue injury.

    Science.gov (United States)

    Bennett, M; Best, T M; Babul, S; Taunton, J; Lepawsky, M

    2005-10-19

    Soft tissue injuries (including muscle damage after unaccustomed exercise) are common and are often associated with athletic activity. Hyperbaric oxygen therapy (HBOT) is the therapeutic administration of 100% oxygen at environmental pressures greater than one atmosphere. To assess the benefits and harms of HBOT for treating soft tissue injury, including delayed onset muscle soreness (DOMS). We searched the following in July 2004: CENTRAL, MEDLINE, EMBASE, CINAHL, DORCTIHM and reference lists from relevant articles. Relevant journals were handsearched and researchers in the field contacted. Randomised trials comparing the effect on closed soft tissue injury (including DOMS) of therapeutic regimens which include HBOT with those that exclude HBOT (with or without sham therapy). Four reviewers independently evaluated study quality and extracted data. Most of the data presented in the review were extracted from graphs in the trial reports. Nine small trials involving 219 participants were included. Two trials compared HBOT versus sham therapy on acute closed soft tissue injuries (ankle sprain and medial collateral knee ligament injury respectively). The other seven trials examined the effect of HBOT on DOMS following eccentric exercise in unconditioned volunteers. All 32 participants of the ankle sprain trial returned to their normal activities. There were no significant differences between the two groups in time to recovery, functional outcomes, pain, or swelling. There was no difference between the two groups in knee function scores in the second acute injury trial; however, intention-to-treat analysis was not possible for this trial. Pooling of data from the seven DOMS trials showed significantly and consistently higher pain at 48 and 72 hours in the HBOT group (mean difference in pain score at 48 hours [0 to 10 worst pain] 0.88, 95% CI 0.09 to 1.67, P = 0.03) in trials where HBOT was started immediately. There were no differences between the two groups in longer

  16. EFFECT OF STATIC STRETCHING AND LPG SYSTEM TECHNIQUE ON TREATMENT AND PREVENT OF DELAYED ONSET MUSCLE SORENESS

    OpenAIRE

    Vahideh Kianmarz; Afshar Jafari

    2011-01-01

    Purpose: This study was done in order to determining effect of static stretching and LPG systemtechnique on treatment and prevent of delayed onset muscle soreness.Methods: In order to thirtynon-athletic females [aged 21.8±1.15 years; fat percent 23.69±1.43 kg; BMI 21.79±1.52 kg/m2]were voluntarily selected and randomly assigned to equal three groups. The stretching groupexecuted a static stretch of hamstrings muscle for 20 min pre exercise and 12 hours postexercise. Hold each stretch 30 secon...

  17. Study of the Effectiveness of Vibration in Reduction of Delayed Onset Muscle Soreness Resulting after Therapeutic Exercise

    Directory of Open Access Journals (Sweden)

    Khayam-Bashi

    2009-07-01

    Full Text Available Introduction: Delayed Onset Muscle Soreness (DOMS is a common strain resulting during therapeutic exercise with eccentric contractions. This pain can result in loss of interest by the patient and eventually in cancellation of the routine. The purpose of the present study was to determine whether vibration could have an affect on delayed onset muscle soreness. We hypothesized that the vibration training would decrease DOMS. Methods: Subjects comprised of 30 male athletes aged 18-26 years. The athletes were involved in regular sports activities since at least three years. Subjects were assigned randomly into two VT (n=15 and Non-VT (n=15 groups. The measurements included the flexed knee angle (FANG, pressure pain threshold (PPT, muscle soreness (SOR of right quadriceps muscle and maximal isometric force (MIF of both quadriceps muscles together (Base-line. A vibrator was used to apply 50 Hz vibration on the left and right quadriceps muscles for 1 min in the VT group. Then both groups trained eccentric exercise. All parameters were determined again 24 hours post-exercise (After- activity. Results: All subjects showed a loss in MIF, decrease in PPT, FANG and increase in SOR 24h after eccentric exercise (p=0/000. But the parameters were statistically significantly different in the VT and Non-VT groups [MIF (p=0/000, PPT (p=0/001, FANG (p=0/02, SOR (p=0/003]. Conclusion: Therapeutic exercise with eccentric contractions results in DOMS, but vibration training before exercise is effective and beneficial in decreasing DOMS.

  18. The effect of passive stretching on delayed onset muscle soreness, and other detrimental effects following eccentric exercise

    DEFF Research Database (Denmark)

    Lund, Henrik; Vestergaard-Poulsen, P; Kanstrup, I.L.

    1998-01-01

    The aim of this study was to measure if passive stretching would influence delayed onset muscle soreness (DOMS), dynamic muscle strength, plasma creatine kinase concentration (CK) and the ratio of phosphocreatine to inorganic phosphate (PCr/P(i)) following eccentric exercise. Seven healthy......, CK and muscle pain were measured before the eccentric exercise (day 0) and the following 7 d. In the second experiment daily passive stretching (3 times of 30 s duration, with a pause of 30 s in between) of m. quadriceps was included in the protocol. The stretching was performed before...... subjects reported pain in the right m. quadriceps with a peak 48 h after exercise. There was no difference in the reported variables between experiments one and two. It is concluded that passive stretching did not have any significant influence on increased plasma-CK, muscle pain, muscle strength...

  19. Linear and nonlinear analyses of multi-channel mechanomyographic recordings reveal heterogeneous activation of wrist extensors in presence of delayed onset muscle soreness.

    Science.gov (United States)

    Madeleine, Pascal; Hansen, Ernst A; Samani, Afshin

    2014-12-01

    In this study, we applied multi-channel mechanomyographic (MMG) recordings in combination with linear and nonlinear analyses to investigate muscular and musculotendinous effects of high intensity eccentric exercise. Twelve accelerometers arranged in a 3 × 4 matrix over the dominant elbow muscles were used to detect MMG activity in 12 healthy participants. Delayed onset muscle soreness was induced by repetitive high intensity eccentric contractions of the wrist extensor muscles. Average rectified values (ARV) as well as percentage of recurrence (%REC) and percentage of determinism (%DET) extracted from recurrence quantification analysis were computed from data obtained during static-dynamic contractions performed before exercise, immediately after exercise, and in presence of muscle soreness. A linear mixed model was used for the statistical analysis. The ARV, %REC, and %DET maps revealed heterogeneous MMG activity over the wrist extensor muscles before, immediately after, and in presence of muscle soreness (P<0.01). The ARVs were higher while the %REC and %DET were lower in presence of muscle soreness compared with before exercise (P<0.05). The study provides new key information on linear and nonlinear analyses of multi-channel MMG recordings of the wrist extensor muscles following eccentric exercise that results in muscle soreness. Recurrence quantification analysis can be suggested as a tool for detection of MMG changes in presence of muscle soreness.

  20. Provocation of delayed-onset muscle soreness in the human jaw-closing muscles

    NARCIS (Netherlands)

    Türker, K.S.; Koutris, M.; Sümer, N.C.; Atis, E.S.; Linke, I.R.; Lobbezoo, F.; Naeije, M.

    2010-01-01

    Eccentric contractions of jaw-closing muscles are difficult to perform. This may explain why fatigue-inducing experiments performed so far suggest the jaw-closing muscles to be fatigue resistant. Aim of this study was to construct an apparatus that can impose intense eccentric contractions to the ja

  1. Progress Delayed Onset Muscle Soreness%延迟性肌肉酸痛研究进展

    Institute of Scientific and Technical Information of China (English)

    刘志锋

    2015-01-01

    机体大强度或不习惯的运动,尤其是离心运动,常常会引起肌肉的延迟性酸痛,并在运动后的2-3天达到高峰,伴有一系列的肌肉结构、组织学及生物化学的改变,严重时会影响到人们健身及训练的效果。延迟性肌肉酸痛是体育运动中一种常见的现象。有关其研究已有百年的历史,但其产生的机制至今仍不清楚,也没有找到真正有效地清除延迟性肌肉酸痛的方法。文章运用文献资料法对国内有关延迟性肌肉酸痛的发生机制及治疗方法进行综述,并提出一些研究的不足和展望,为延迟性肌肉酸痛的进一步研究提供参考。%Intensive body strength exercise and unaccustomed exercise especially centrifugal movement will inevitably lead to delayed muscle soreness which will go at peak after 2 to 3 days. The symptom also appears as the muscle structure and biochemistry changes happens. It will leave harmful consequences in people’s training. Delayed onset muscle soreness is a common sports phenomenon. As for the research, it has lasts for centuries but the mechanism is still unclear as to what produces the harmful body reaction and how to find a truly effective way to remove DOMS . In this paper, by appliance of literature reviews on the mechanisms and treatment of delayed onset muscle soreness related to the occurrence of domestic reviewed, hatefully it will make up a number of shortcomings and deliver outlook studies providing a reference for further study of delayed onset muscle soreness.

  2. Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice.

    Science.gov (United States)

    Borghi, Sergio M; Zarpelon, Ana C; Pinho-Ribeiro, Felipe A; Cardoso, Renato D R; Martins-Pinge, Marli C; Tatakihara, Roberto I; Cunha, Thiago M; Ferreira, Sergio H; Cunha, Fernando Q; Casagrande, Rubia; Verri, Waldiceu A

    2014-04-10

    The injection of cytokines such as TNF-α induces muscle pain. Herein, it was addressed the role of endogenous TNF-α/TNFR1 signaling in intense acute swimming-induced muscle mechanical hyperalgesia in mice. Mice were exposed to water during 30 s (sham) or to a single session of 30-120 min of swimming. Intense acute swimming induced a dose-dependent (time of exercise-dependent) muscle mechanical hyperalgesia, which peaked after 24 h presenting characteristics of delayed onset muscle soreness (DOMS). The intense acute swimming (120 min)-induced muscle mechanical hyperalgesia was reduced in etanercept (soluble TNF receptor) treated and TNFR1 deficient ((-/-)) mice. TNF-α levels increased 2 and 4 h after intense acute swimming in soleus muscle (but not in gastrocnemius), and spinal cord, respectively. Exercise induced an increase of myeloperoxidase activity and decrease in reduced glutathione levels in an etanercept-sensitive and TNFR1-dependent manners in the soleus muscle, but not in the gastrocnemius muscle. Concluding, TNF-α/TNFR1 signaling mediates intense acute swimming-induced DOMS by an initial role in the soleus muscle followed by spinal cord, inducing muscle inflammatory hyperalgesia and oxidative stress. The knowledge of these mechanisms might contribute to improve the training of athletes, individuals with physical impairment and intense training such as military settings.

  3. EFFECT OF ICE BAG, DYNAMIC STRETCHING AND COMBINED TREATMENTS ON THE PREVENTION AND TREATMENT OF DELAY ONSET MUSCLE SORENESS

    Directory of Open Access Journals (Sweden)

    Warin Krityakiarana

    2014-12-01

    Full Text Available Objective: To investigate the effects of ice bag, dynamic stretching, combined ice and dynamic stretching, and control (non-treated on the prevention and treatment of delayed onset muscle soreness (DOMS in biceps muscle. Subjects: Fifty-five participants (aged 18 to 25 years were engaged in this study and randomly assigned into four groups (control group (non-treated (CG, n = 13; ice bag, n = 14; dynamic stretching, n = 14; and combined treatment, n = 14. Method: Before inducing DOMS, the range of motion (ROM and maximum voluntary contraction (MVC were measured. The dynamic stretching was performed before inducing DOMS. Subjects performed biceps eccentric exercise at 110% of the predicted one-repetition maximum (1-RM, for each subject, to induce muscle soreness. Pain, ROM and MVC were assessed at 0, 24, 48, 72, and 96 hours after induction of DOMS. Results: These non-significant results for mode of treatment and time interaction showed that combined treatment, ice bag, or dynamic stretching alone is not effective at significantly reducing the symptoms of DOMS. Conclusion: These results are non-significant, the pattern of the data showed that the combined treatment may be contraindicated in the prevention of DOMS and ice bag or dynamic stretching might be the best choice of treatment. Further investigation is strongly recommended.

  4. Electrical Resistance as A Measure of Soft Tissue Injuryfrom Delayed Onset Muscle Soreness

    Institute of Scientific and Technical Information of China (English)

    Timothy Hui; Jerrold Petrofsky; Iman Akef Khowailed

    2014-01-01

    Assessment of muscle damage relies commonly on subjective sensation of pain. The purpose of this research was to test thevalidity of microcurrent conductance on skin over injured tissue to quantify soft tissue injury and recovery following heavy exercisecompared to other indexes of muscle soreness. A randomized, controlled, single-blinded, 1-week trial on 60 subjects.Setting-University Interventions: Subjects did 3 sets of squats for 5 min each. There were 3 groups of 20 subjects. One did nothing andone had heat applied for 8 h post exercise. The final group had heat 24 h after exercise. Tissue resistance and muscle strength force tomove the knee, analog visual pain scale. In the control group, microcurrent continually decreased, eventually decreasing 32% by thethird day post exercise. When heat was given immediately following exercise, microcurrent was 26% greater (P 〈 0.001). The painscale rose to 3.1/10 as opposed to 5.4/10 for controls. Strength and muscle elasticity stayed mostly constant after heat as opposed to a28% decrease in strength and increase in stiffness in the control subjects. For 24 h delayed heat, microcurrent was 14% greater(P 〈 0.02), and was unchanged for the first 24 h when no therapy was given. Pain scale rose to 4.8/10. Stiffness was unchanged whilemuscle strength decreased the same as controls. Microcurrent shows agreement with loss of strength, and stiffness from DOMS but notthe subjective pain measure. It appears that microcurrent is a good measure of muscle damage.

  5. The Effects of Proprioceptive Neuromuscular Facilitation Stretching on Post-Exercise Delayed Onset Muscle Soreness in Young Adults.

    Science.gov (United States)

    McGRATH, Ryan P; Whitehead, James R; Caine, Dennis J

    Until recently, the scientific community believed that post-exercise stretching could reduce delayed onset muscle soreness (DOMS), but recent reviews of studies on the topic have concluded that pre- or post-exercise static stretching has no effect on mitigating DOMS. However, the effect of proprioceptive neuromuscular facilitation (PNF) post-exercise stretching on preventing DOMS has not been adequately studied. The purpose of this study was to determine the effect of post-exercise PNF stretching on DOMS. Young adult participants (N=57) were randomly assigned to a PNF stretching group (n=19), a static stretching group (n=20), and to a no-stretching control group (n=18). All participants completed exercise designed to induce DOMS prior to post-exercise experimental stretching protocols. Participants rated their soreness level on a pain scale 24 and 48 hours post-exercise. A 3 × 2 mixed ANOVA showed there was an effect for time (p<.01). Post hoc testing revealed that DOMS pain significantly decreased (p<.05) from 24 to 48 hours post-exercise for the PNF and control groups, but not for the static stretching group. Other analyses revealed a significant correlation (r=.61, p<.01) between the pre- and post-exercise stretch scores and the 48 hour post-exercise pain score for the PNF group. Consistent with the results of previous research on post-exercise static stretching, these results indicate that post-exercise PNF stretching also does not prevent DOMS. However, the correlation analysis suggests it is possible the pre-stretch muscle contractions of the post-exercise PNF protocol may have placed a load on an already damaged muscle causing more DOMS for some participants.

  6. Kinesiology Tape does not Affect Serum Creatine Kinase Level and Quadriceps Activity during Recovery from Delayed-Onset Muscle Soreness

    Directory of Open Access Journals (Sweden)

    Naoko Aminaka

    2017-01-01

    Full Text Available Background: Delayed-onset muscle soreness (DOMS causes muscle damage and edema that can hinder performance and increase risks for secondary injuries. Kinesiology Tape (KT may be an effective modality for aiding in recovery, however, no study has investigated the effects of KT on the physiological biomarkers such as serum creatine kinase (CK level, concurrently with measures of performance and function, during recovery from DOMS. Objective: Investigate the effects of KT on serum CK level, electromyographic (EMG activity of the quadriceps muscles, and performances of countermovement jump (CMJ and triple single-leg hop for distance (HopD during recovery from DOMS. Method: Fifty-eight healthy college-age participants were randomly assigned to KT (n=15, placebo (n=19, and control (n=24 groups. Serum CK level and quadriceps EMG activity and performance during CMJ and HopD were collected at baseline, immediately after repetitive eccentric quadriceps exercise, 48 hours, and 72 hours post-exercise. The EMG recording of rectus femoris, vastus medialis, and vastus lateralis during the CMJ and HopD were normalized to the baseline maximum voluntary isometric contraction. Results: A significant main effect of time on the serum CK level, EMG activity, and performance (p0.05. Conclusion: Taping interventions did not improve the serum CK level or muscle activity and performance during recovery from DOMS. Kinesiology tape may not be the first choice of method for enhancing recovery from DOMS in otherwise healthy individuals.

  7. [Delayed post effort muscle soreness].

    Science.gov (United States)

    Coudreuse, J M; Dupont, P; Nicol, C

    2004-08-01

    Muscle intolerance to exercise may result from different processes. Diagnosis involves confirming first the source of pain, then potential pathological myalgia. Delayed-onset muscle soreness (DOMS), commonly referred as tiredness, occurs frequently in sport. DOMS usually develops 12-48 h after intensive and/or unusual eccentric muscle action. Symptoms usually involve the quadriceps muscle group but may also affect the hamstring and triceps surae groups. The muscles are sensitive to palpation, contraction and passive stretch. Acidosis, muscle spasm and microlesions in both connective and muscle tissues may explain the symptoms. However, inflammation appears to be the most common explanation. Interestingly, there is strong evidence that the progression of the exercise-induced muscle injury proceeds no further in the absence of inflammation. Even though unpleasant, DOMS should not be considered as an indicator of muscle damage but, rather, a sign of the regenerative process, which is well known to contribute to the increased muscle mass. DOMS can be associated with decreased proprioception and range of motion, as well as maximal force and activation. DOMS disappears 2-10 days before complete functional recovery. This painless period is ripe for additional joint injuries. Similarly, if some treatments are well known to attenuate DOMS, none has been demonstrated to accelerate either structural or functional recovery. In terms of the role of the inflammatory process, these treatments might even delay overall recovery.

  8. Piroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise

    Directory of Open Access Journals (Sweden)

    J-L. Croisier

    1996-01-01

    Full Text Available To test the hypothesis that delayed onset muscular soreness (DOMS following intense eccentric muscle contraction could be due to increased production of prostaglandin E2 (PGE2, ten healthy male subjects were studied. Using a double-blind randomized crossover design, each subject performed two isokinetic tests separated by a period of at least 6 weeks: once with placebo, and once with piroxicam (Feldene®. They were given one capsule containing either placebo or piroxicam (20 mg per day for 6 days with initial doses given starting 3 days prior to isokinetic testing. Exercise consisted of eight stages of five maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases, on a Kin Trex device at 60°/s angular velocity. The subjective presence and intensity of DOMS were evaluated using a visual analogue scale immediately after, and 24 and 48 h after each test. The mean plasma concentration of PGE2 measured at rest and after exercise was significantly lower in the group treated with piroxicam (p < 0.05. However, statistical analysis (two-way ANOVA test revealed that exercise did not cause any significant change of mean plasma PGE2 over time in either of the two groups. Eccentric work was followed by severe muscle pain in extensor and flexor muscle groups. Maximal soreness was noted 48 h postexercise. Serum creatine kinase activity and the serum concentration of myoglobin increased significantly, and reached peak values 48 h after exercise in both experimental conditions (p < 0.001. By paired t-test, it appeared that there were no significant differences in the serum levels of these two markers of muscle damage between the two groups at any time point. We conclude that: (1 oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2 the hypothetical role of increased PGE2 production in eccentric exercise-induced muscle damage, DOMS, and reduced

  9. Piroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise

    Science.gov (United States)

    Croisier, J-L.; Monfils, T.; Deby-Dupon, G.; Fafchamps, M.; Venneman, I.; Crielaard, J-M.; Juchmès-Ferir, A.; Lhermerout, C.; Lamy, M.; Deby, C.

    1996-01-01

    To test the hypothesis that delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E2 (PGE2), ten healthy male subjects were studied. Using a double-blind randomized crossover design, each subject performed two isokinetic tests separated by a period of at least 6 weeks: once with placebo, and once with piroxicam (Feldene®). They were given one capsule containing either placebo or piroxicam (20 mg) per day for 6 days with initial doses given starting 3 days prior to isokinetic testing. Exercise consisted of eight stages of five maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases, on a Kin Trex device at 60°/s angular velocity. The subjective presence and intensity of DOMS were evaluated using a visual analogue scale immediately after, and 24 and 48 h after each test. The mean plasma concentration of PGE2 measured at rest and after exercise was significantly lower in the group treated with piroxicam (p < 0.05). However, statistical analysis (two-way ANOVA test) revealed that exercise did not cause any significant change of mean plasma PGE2 over time in either of the two groups. Eccentric work was followed by severe muscle pain in extensor and flexor muscle groups. Maximal soreness was noted 48 h postexercise. Serum creatine kinase activity and the serum concentration of myoglobin increased significantly, and reached peak values 48 h after exercise in both experimental conditions (p < 0.001). By paired t-test, it appeared that there were no significant differences in the serum levels of these two markers of muscle damage between the two groups at any time point. We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE2 production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic

  10. The Effects of Ice Massage, Ice Massage with Exercise, and Exercise on the Prevention and Treatment of Delayed Onset Muscle Soreness

    Science.gov (United States)

    Isabell, William Kirk; Durrant, Earlene; Myrer, William; Anderson, Shauna

    1992-01-01

    We investigated the effects of ice massage, ice massage with exercise, and exercise on the prevention and treatment of delayed onset muscle soreness (DOMS). Twenty-two subjects were randomly assigned to one of four groups. Preexercise measures were recorded for range of motion (ROM), strength, perceived soreness, and serum creatine kinase (CK) levels. Subjects performed up to 300 concentric/eccentric contractions of the elbow flexors with 90% of their 10 repetition maximum to induce muscle soreness. Dependent variables were assessed at 2, 4, 6, 24, 48, 72, 96, and 120 hours postexercise. Significant differences occurred in all variables with respect to time (ANOVA(p<.05)). However, no significant mode of treatment, or mode of treatment/assessment time interaction was present. Decreases in range of motion and flexion strength correspond with increases in perceived soreness. The nonsignificant mode of treatment/assessment time interaction suggests that the use of ice massage, ice massage with exercise, or exercise alone is not effective in significantly reducing the symptoms of delayed onset muscle soreness. In fact, though not statistically significant, the pattern of the data suggested the use of ice in the treatment of DOMS may be contraindicated. Further investigation is recommended. PMID:16558163

  11. Factors in delayed muscle soreness.

    Science.gov (United States)

    Abraham, W M

    1977-01-01

    The possible causes of delayed muscle soreness which occur 24 to 48 hr after exercise were examined from three different approaches, each designed to test an existing hypothesis. Surface electromyograms were used to evaluate the muscle spasm theory; the possibility of actual muscle cell damage was monitored by the presence of myoglobinuria, while the ratio of hydroxyproline/creatinine (OHP/Cr) in 24 hr urine collection was used as a marker for connective tissue involvement. In the first study, although all volunteers developed muscle soreness 24 and 48 hr after exercise, no change in the EMG activity of the sore muscles was observed. Myoglobin excretion was found in 88% of the subjects who developed soreness. However, in a second study, 92% of the subject who performed both moderate and heavy exercise but did not develop muscle soreness had myoglobinuria. In contrast, during a third experiment subjects on gelatin-free diets showed an increase (P less than .1) in the OHP/Cr between control (.020+/-.001) and 48 hr post-exercise (.002+/-.001, X+/-SE). Soreness resulted in all cases. When the OHP/Cr value is taken for the day of maximal soreness, the post-exercise mean increases to .024+/-.001 and the level of significance rises (P less than .005). These observations support the concept that exercise induced soreness may be related to disruption of the connective tissue elements in the muscle and/or their attachments.

  12. Effect of Transcutaneous Electrical Nerve Stimulation, Cold, and a Combination Treatment on Pain, Decreased Range of Motion, and Strength Loss Associated with Delayed Onset Muscle Soreness

    OpenAIRE

    Denegar, Craig R.; Perrin, David H.

    1992-01-01

    Athletic trainers have a variety of therapeutic agents at their disposal to treat musculoskeletal pain, but little objective evidence exists of the efficacy of the modalities they use. In this study, delayed onset muscle soreness (DOMS) served as a model for musculoskeletal injury in order to: (1) compare the changes in perceived pain, elbow extension range of motion, and strength loss in subjects experiencing DOMS in the elbow flexor muscle group following a single treatment with either tran...

  13. Effects of a non-steroidal anti-inflammatory drug on delayed onset muscle soreness and indices of damage.

    Science.gov (United States)

    Donnelly, A E; McCormick, K; Maughan, R J; Whiting, P H; Clarkson, P M

    1988-01-01

    Twenty untrained male volunteers were required to run downhill for 45 minutes on a motor driven treadmill to induce muscle soreness. The volunteers took diclofenac or placebo before and for 72 hours after two runs 10 weeks apart, in a randomised double blind crossover design. Subjective soreness was assessed before and at intervals up to 72 hours after each run; venous blood samples, collected at the same time intervals, were used to estimate serum activities of creatine kinase, lactate dehydrogenase and aspartate aminotransferase and serum concentrations of creatinine and urea. Subjective soreness and the biochemical parameters increased after both runs, although the serum enzyme response to the second run was reduced. Diclofenac had no influence on the serum biochemical response to downhill running. Although overall soreness was not affected by diclofenac, individual soreness measurements were reduced by diclofenac at the first period of the study. These results suggest that diclofenac does not influence muscle damage, but may slightly reduce the associated soreness. PMID:3370401

  14. Flexion Relaxation Ratio Not Responsive to Acutely Induced Low Back Pain from a Delayed Onset Muscle Soreness Protocol

    Science.gov (United States)

    Horn, Maggie E.; Bishop, Mark D.

    2013-01-01

    Background. The flexion relaxation ratio (FRR) has been suggested as a measure of muscular performance in patients with low back pain (LBP). The purpose of this study was to investigate whether the FRR was responsive to acute LBP produced from a delayed onset muscle soreness (DOMS) protocol. Methods. Fifty-one pain-free volunteers performed DOMS to induce LBP. Current pain intensity, trunk flexion range of motion (ROM), and passive straight leg raise (SLR) were measured at baseline, 24 and 48 hours after DOMS. Participants were categorized into pain groups based on reported current pain intensity. Changes in FRR, trunk flexion ROM, and SLR ROM were examined using two-way repeated measures analysis of variance. Results. Pain group was not found to have a significant effect on FRR (F1,29 = 0.054, P = 0.818), nor were there any two-way interactions for changes in FRR. The pain group had decreased trunk flexion ROM compared to the minimal pain group (F1,38 = 7.21, P = 0.011), but no decreases in SLR ROM (F1,38 = 3.51, P = 0.057) over time. Interpretation. There were no differences in FRR based on reported pain intensity of LBP from a DOMS protocol. The responsiveness of FRR might be limited in patients with acute onset LBP of muscular origin. PMID:27335879

  15. A Comparison between Chocolate Milk and a Raw Milk Honey Solution’s Influence on Delayed Onset of Muscle Soreness

    Directory of Open Access Journals (Sweden)

    Andrew Hatchett

    2016-03-01

    Full Text Available This investigation sought to examine the effect that a chocolate milk solution (CMS and a raw milk solution (RMS had on lower extremity induced delayed onset of muscle soreness (DOMS. Twenty trained male participants completed a set of questionnaires, prior to completing a lower extremity DOMS protocol, to determine the level of discomfort and functional limitations. Once the DOMS protocol was completed, participants were randomly assigned to either the CM or RM group. Once assigned, participants ingested 240 mL of the respective solution and completed the same set of questionnaires immediately post, 24-, 48- and 72-h post DOMS protocol. Additionally, for 10 days post-ingestion participants were contacted to learn if any negative effects were experienced as a result of ingesting either solution. Both groups reported an increase in lower extremity discomfort at each data collection interval post-DOMS protocol (post, 24-, 48- and 72-h. Participants assigned to the RM group reported high discomfort post and a relative decline in discomfort from immediately post-DOMS protocol to 72-h post. The RMS group reported substantially less discomfort at 72-h when compared to the CMS group. Ingestion of a raw milk solution immediately post strength exercise can substantially reduce the level of self-reported discomfort associated with DOMS.

  16. Cold-water immersion versus passive therapy to decrease delayed onset muscular soreness: a CAT

    OpenAIRE

    2014-01-01

    Introduction Late onset muscle soreness, also known as delayed onset muscle soreness, is a painful musculoskeletal condition that may occur 24-48 and up to 72 hours after the completion of unusual physical or high intensity exercise involving eccentric muscle activity. In the field of physical rehabilitation, immersion in cold water is a common intervention mainly used in sports medicine, to minimize delayed onset muscle soreness and promote recovery after exercise. Objective To ass...

  17. The Effect of Warm-Up and Cool-Down Exercise on Delayed Onset Muscle Soreness in the Quadriceps Muscle: a Randomized Controlled Trial

    Science.gov (United States)

    Olsen, Olav; Sjøhaug, Mona; van Beekvelt, Mireille; Mork, Paul Jarle

    2012-01-01

    The aim of the present study was to investigate the effect of warm-up and cool-down exercise on delayed onset of muscle soreness at the distal and central parts of rectus femoris following leg resistance exercise. Thirty-six volunteers (21 women, 15 men) were randomly assigned to the warm-up (20 min ergometer cycling prior to the resistance exercise), cool-down (20 min cycling after the resistance exercise), or control group performing resistance exercise only. The resistance exercise consisted of front lunges (10×5 repetitions/sets) with external loading of 40% (women) and 50% (men) of body mass. Primary outcomes were pressure pain threshold along rectus femoris and maximal isometric knee extension force. Data were recorded before the resistance exercise and on the two consecutive days. Pressure pain threshold at the central muscle belly was significantly reduced for the control group on both day 2 and 3 (p≤0.003) but not for the warm-up group (p≥0.21). For the cool-down group, pressure pain threshold at the central muscle belly was significantly reduced on day 2 (p≤0.005) and was also lower compared to the warm-up group (p=0.025). Force was significantly reduced on day 2 and 3 for all groups (p<0.001). This study indicates that aerobic warm-up exercise performed prior to resistance exercise may prevent muscle soreness at the central but not distal muscle regions, but it does not prevent loss of muscle force. PMID:23486850

  18. Perceived Muscle Soreness in Recreational Female Runners.

    Science.gov (United States)

    Burnett, D; Smith, K; Smeltzer, C; Young, K; Burns, S

    The purpose of this study was to determine if rating of perceived exertion correlated with perceived muscle soreness during delayed onset muscle soreness (DOMS) in female runners. This study examined the pre and post running economy measures and perceived muscle soreness before and after a 30-min downhill run (DHR) at -15% grade and 70% of the subjects predetermined maximum oxygen uptake (VO2 peak). Six female recreational runners (mean age = 24.5) performed level running at 65%, 75%, and 85% of their VO2 peak prior to DHR (baseline economy runs), as well as, immediately following and 4 successive days after the DHR. Subjective response related to perceived muscle soreness increased significantly from a mean of 2 (pre DHR) to 62 (2 days post DHR) on a scale of 1-100. Creatine kinase levels and oxygen consumption increased post DHR compared to pre DHR. Rating of perceived exertion did not change between the economy runs performed prior to or at any point after the DHR. Perceived muscle soreness is a better tool than the RPE scale to monitor exercise intensity for recreational female runners during periods of DOMS and running economy is adversely affected by DOMS.

  19. Perceived Muscle Soreness in Recreational Female Runners

    Science.gov (United States)

    Burnett, D.; Smith, K.; Smeltzer, C.; Young, K.; Burns, S.

    2010-01-01

    The purpose of this study was to determine if rating of perceived exertion correlated with perceived muscle soreness during delayed onset muscle soreness (DOMS) in female runners. This study examined the pre and post running economy measures and perceived muscle soreness before and after a 30-min downhill run (DHR) at −15% grade and 70% of the subjects predetermined maximum oxygen uptake (VO2 peak). Six female recreational runners (mean age = 24.5) performed level running at 65%, 75%, and 85% of their VO2 peak prior to DHR (baseline economy runs), as well as, immediately following and 4 successive days after the DHR. Results: Subjective response related to perceived muscle soreness increased significantly from a mean of 2 (pre DHR) to 62 (2 days post DHR) on a scale of 1–100. Creatine kinase levels and oxygen consumption increased post DHR compared to pre DHR. Rating of perceived exertion did not change between the economy runs performed prior to or at any point after the DHR. Conclusion: Perceived muscle soreness is a better tool than the RPE scale to monitor exercise intensity for recreational female runners during periods of DOMS and running economy is adversely affected by DOMS. PMID:27182336

  20. Delayed onset muscle soreness: No pain, no gain? The truth behind ...

    African Journals Online (AJOL)

    4Researcher, Section Sports Medicine, University of Pretoria, Pretoria. Correspondence to: .... supplements in the prevention and treatment of exercise- induced ... did not eliminate muscle injury.16 Studies conducted in this area are limited in ...

  1. Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise.

    Science.gov (United States)

    Ra, Song-Gyu; Miyazaki, Teruo; Ishikura, Keisuke; Nagayama, Hisashi; Suzuki, Takafumi; Maeda, Seiji; Ito, Masaharu; Matsuzaki, Yasushi; Ohmori, Hajime

    2013-01-01

    Taurine (TAU) has a lot of the biological, physiological, and pharmocological functions including anti-inflammatory and anti-oxidative stress. Although previous studies have appreciated the effectiveness of branched-chain amino acids (BCAA) on the delayed-onset muscle soreness (DOMS), consistent finding has not still convinced. The aim of this study was to examine the additional effect of TAU with BCAA on the DOMS and muscle damages after eccentric exercise. Thirty-six untrained male volunteers were equally divided into four groups, and ingested a combination with 2.0 g TAU (or placebo) and 3.2 g BCAA (or placebo), thrice a day, 2 weeks prior to and 4 days after elbow flexion eccentric exercise. Following the period after eccentric exercise, the physiological and blood biochemical markers for DOMS and muscle damage showed improvement in the combination of TAU and BCAA supplementation rather than in the single or placebo supplementations. In conclusion, additional supplement of TAU with BCAA would be a useful way to attenuate DOMS and muscle damages induced by high-intensity exercise.

  2. Effect of Cold Water Immersion or Contrast Water Therapy on Muscle Soreness After Exercise

    National Research Council Canada - National Science Library

    C A Lauber; S Hickle; J Jargstorf; W West

    2017-01-01

    An abstract of a study by Lauber et al determining if post-exercise cold-water immersion decreases muscle soreness compared to contrast water therapy at 48 hours post delayed onset muscle soreness (DOMS...

  3. A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness.

    Science.gov (United States)

    Ely, Matthew R; Romero, Steven A; Sieck, Dylan C; Mangum, Joshua E; Luttrell, Meredith J; Halliwill, John R

    2017-03-01

    Histamine contributes to elevations in skeletal muscle blood flow following exercise, which raises the possibility that histamine is an important mediator of the inflammatory response to exercise. We examined the influence of antihistamines on postexercise blood flow, inflammation, muscle damage, and delayed-onset muscle soreness (DOMS) in a model of moderate exercise-induced muscle damage. Subjects consumed either a combination of fexofenadine and ranitidine (blockade, n = 12) or nothing (control, n = 12) before 45 min of downhill running (-10% grade). Blood flow to the leg was measured before and throughout 120 min of exercise recovery. Markers of inflammation, muscle damage, and DOMS were obtained before and at 0, 6, 12, 24, 48, and 72 h postexercise. At 60 min postexercise, blood flow was reduced ~29% with blockade compared with control (P < 0.05). Markers of inflammation were elevated after exercise (TNF-ɑ, IL-6), but did not differ between control and blockade. Creatine kinase concentrations peaked 12 h after exercise, and the overall response was greater with blockade (18.3 ± 3.2 kU·l(-1)·h(-1)) compared with control (11.6 ± 2.0 kU·l(-1)·h(-1); P < 0.05). Reductions in muscle strength in control (-19.3 ± 4.3% at 24 h) were greater than blockade (-7.8 ± 4.8%; P < 0.05) and corresponded with greater perceptions of pain/discomfort in control compared with blockade. In conclusion, histamine-receptor blockade reduced postexercise blood flow, had no effect on the pattern of inflammatory markers, increased serum creatine kinase concentrations, attenuated muscle strength loss, and reduced pain perception following muscle-damaging exercise.NEW & NOTEWORTHY Histamine appears to be intimately involved with skeletal muscle during and following exercise. Blocking histamine's actions during muscle-damaging exercise, via common over-the-counter antihistamines, resulted in increased serum creatine kinase, an indirect marker of muscle damage. Paradoxically, blocking

  4. Can a standard dose of eicosapentaenoic acid (EPA supplementation reduce the symptoms of delayed onset of muscle soreness?

    Directory of Open Access Journals (Sweden)

    Houghton David

    2012-01-01

    Full Text Available Abstract Background Unaccustomed exercise can result in delayed onset of muscle soreness (DOMS which can affect athletic performance. Although DOMS is a useful tool to identify muscle damage and remodelling, prolonged symptoms of DOMS may be associated with the over-training syndrome. In order to reduce the symptoms of DOMS numerous management strategies have been attempted with no significant effect on DOMS-associated cytokines surge. The present study aimed to investigate the acute and chronic effects of a 2 × 180 mg per day dose of eicosapentaenoic acid (EPA on interleukin-6 (IL-6 mediated inflammatory response and symptoms associated with DOMS. Methods Seventeen healthy non-smoking females (age 20.4 ± 2.1 years, height 161.2 ± 8.3 cm and mass 61.48 ± 7.4 kg were randomly assigned to either placebo (N = 10 or EPA (N = 7. Serum IL-6, isometric and isokinetic (concentric and eccentric strength, and rating of perceived exertion (RPE were recorded on four occasions: i-prior to supplementation, ii-immediately after three weeks of supplementation (basal effects, iii-48 hours following a single bout of resistance exercise (acute training response effects, and iv-48 hours following the last of a series of three bouts of resistance exercise (chronic training response effects. Results There was only a group difference in the degree of change in circulating IL-6 levels. In fact, relative to the first baseline, by the third bout of eccentric workout, the EPA group had 103 ± 60% increment in IL-6 levels whereas the placebo group only had 80 ± 26% incremented IL-6 levels (P = 0.020. We also describe a stable multiple linear regression model which included measures of strength and not IL-6 as predictors of RPE scale. Conclusion The present study suggests that in doubling the standard recommended dose of EPA, whilst this may still not be beneficial at ameliorating the symptoms of DOMS, it counter intuitively appears to enhance the cytokine response to

  5. Can a standard dose of eicosapentaenoic acid (EPA) supplementation reduce the symptoms of delayed onset of muscle soreness?

    Science.gov (United States)

    2012-01-01

    Background Unaccustomed exercise can result in delayed onset of muscle soreness (DOMS) which can affect athletic performance. Although DOMS is a useful tool to identify muscle damage and remodelling, prolonged symptoms of DOMS may be associated with the over-training syndrome. In order to reduce the symptoms of DOMS numerous management strategies have been attempted with no significant effect on DOMS-associated cytokines surge. The present study aimed to investigate the acute and chronic effects of a 2 × 180 mg per day dose of eicosapentaenoic acid (EPA) on interleukin-6 (IL-6) mediated inflammatory response and symptoms associated with DOMS. Methods Seventeen healthy non-smoking females (age 20.4 ± 2.1 years, height 161.2 ± 8.3 cm and mass 61.48 ± 7.4 kg) were randomly assigned to either placebo (N = 10) or EPA (N = 7). Serum IL-6, isometric and isokinetic (concentric and eccentric) strength, and rating of perceived exertion (RPE) were recorded on four occasions: i-prior to supplementation, ii-immediately after three weeks of supplementation (basal effects), iii-48 hours following a single bout of resistance exercise (acute training response effects), and iv-48 hours following the last of a series of three bouts of resistance exercise (chronic training response effects). Results There was only a group difference in the degree of change in circulating IL-6 levels. In fact, relative to the first baseline, by the third bout of eccentric workout, the EPA group had 103 ± 60% increment in IL-6 levels whereas the placebo group only had 80 ± 26% incremented IL-6 levels (P = 0.020). We also describe a stable multiple linear regression model which included measures of strength and not IL-6 as predictors of RPE scale. Conclusion The present study suggests that in doubling the standard recommended dose of EPA, whilst this may still not be beneficial at ameliorating the symptoms of DOMS, it counter intuitively appears to enhance the cytokine response to exercise. In a

  6. Use of Cold-Water Immersion to Reduce Muscle Damage and Delayed-Onset Muscle Soreness and Preserve Muscle Power in Jiu-Jitsu Athletes.

    Science.gov (United States)

    Fonseca, Líllian Beatriz; Brito, Ciro J; Silva, Roberto Jerônimo S; Silva-Grigoletto, Marzo Edir; da Silva, Walderi Monteiro; Franchini, Emerson

    2016-07-01

    Cold-water immersion (CWI) has been applied widely as a recovery method, but little evidence is available to support its effectiveness. To investigate the effects of CWI on muscle damage, perceived muscle soreness, and muscle power recovery of the upper and lower limbs after jiu-jitsu training. Crossover study. Laboratory and field. A total of 8 highly trained male athletes (age = 24.0 ± 3.6 years, mass = 78.4 ± 2.4 kg, percentage of body fat = 13.1% ± 3.6%) completed all study phases. We randomly selected half of the sample for recovery using CWI (6.0°C ± 0.5°C) for 19 minutes; the other participants were allocated to the control condition (passive recovery). Treatments were reversed in the second session (after 1 week). We measured serum levels of creatine phosphokinase, lactate dehydrogenase (LDH), aspartate aminotransferase, and alanine aminotransferase enzymes; perceived muscle soreness; and recovery through visual analogue scales and muscle power of the upper and lower limbs at pretraining, postrecovery, 24 hours, and 48 hours. Athletes who underwent CWI showed better posttraining recovery measures because circulating LDH levels were lower at 24 hours postrecovery in the CWI condition (441.9 ± 81.4 IU/L) than in the control condition (493.6 ± 97.4 IU/L; P = .03). Estimated muscle power was higher in the CWI than in the control condition for both upper limbs (757.9 ± 125.1 W versus 695.9 ± 56.1 W) and lower limbs (53.7 ± 3.7 cm versus 35.5 ± 8.2 cm; both P values = .001). In addition, we observed less perceived muscle soreness (1.5 ± 1.1 arbitrary units [au] versus 3.1 ± 1.0 au; P = .004) and higher perceived recovery (8.8 ± 1.9 au versus 6.9 ± 1.7 au; P = .005) in the CWI than in the control condition at 24 hours postrecovery. Use of CWI can be beneficial to jiu-jitsu athletes because it reduces circulating LDH levels, results in less perceived muscle soreness, and helps muscle power recovery at 24 hours postrecovery.

  7. Delayed onset muscle soreness and muscle satellite cells:repair of skeletal muscle injury%延迟性肌肉酸痛与骨骼肌卫星细胞:骨骼肌损伤的修复

    Institute of Scientific and Technical Information of China (English)

    张翔; 柴志铭; 赵丽

    2015-01-01

    背景:长时间或高强度运动出现的骨骼肌纤维损伤是导致骨骼肌损伤直接原因。  目的:文章从修复骨骼肌损伤的客观实际出发,提出骨骼肌损伤后产生的延迟性肌肉酸痛与骨骼肌卫星细胞之间存在某种关系。  方法:检索1961年2月至2015年2月中国知网和PubMed 数据库中相关文献资料,中文检索词:延迟性肌肉酸痛;骨骼肌损伤;骨骼肌卫星细胞;调节因子;英文检索词:Delayed Onset Muscle Soreness;Satel ite Cel s, Skeletal Muscle;Myogenic Regulatory Factors。纳入59篇国内外文献,对骨骼肌损伤伴随的延迟性肌肉疼痛的发生机制做一探讨。  结果与结论:骨骼肌微损伤主要涉及肌细胞生物膜、细胞骨架、肌小节、线粒体等超微结构的破坏和细胞代谢功能紊乱,进而导致骨骼肌收缩功能下降,期间常伴有延迟性肌肉酸痛,其中以离心运动对骨骼肌纤维的微细损伤最为显著;延迟性酸痛的骨骼肌特殊微环境一定程度上刺激骨骼肌卫星细胞生长因子的分泌,持续大强度离心运动引发的延迟性肌肉酸痛的发生时序与骨骼肌卫星细胞增殖时序存在一定的相关性。%BACKGROUND:Skeletal muscle fiber damage that is induced by prolonged or high-intensity exercise directly cause muscle injury. OBJECTIVE:To propose the existence of a relationship between delayed onset muscle soreness and muscle satel ite cel s after skeletal muscle injury from the objective reality. METHODS:A retrieval of CNKI and PubMed databases was done for relevant literature published from February 1961 to February 2015 using the keywords of“delayed onset muscle soreness;skeletal muscle injury;satel ite cel s, skeletal muscle;myogenic regulatory factors”in Chinese and English, respectively. Final y, 59 articles were included to explore the mechanism of skeletal muscle injury accompanied by delayed onset muscle pain

  8. Effects of the hold and relax-agonist contraction technique on recovery from delayed onset muscle soreness after exercise in healthy adults.

    Science.gov (United States)

    Cha, Hyun-Gyu; Kim, Myoung-Kwon

    2015-10-01

    [Purpose] This study was conducted to verify the effects of the hold relax-agonist contraction and passive straight leg raising techniques on muscle activity, fatigue, and range of motion of the hip joint after the induction of delayed onset muscle soreness in the hamstring muscle. [Subjects] Sixty subjects were randomly assigned to a hold relax-agonist contraction group and a passive straight leg raising group. [Methods] Subjects in the experimental group underwent hold relax-agonist contraction at the hamstring muscle, while subjects in the control group underwent passive straight leg raising at the hamstring muscle. [Results] Subjects in the hold relax-agonist contraction group showed a significant increase in hamstring muscle activity and hip joint angle and a significant decrease in muscle fatigue. In the passive straight leg raising group, the hip joint angle increased significantly after the intervention. In the hold relax-agonist contraction group, hamstring muscle activity increased significantly and muscle fatigue decreased significantly. [Conclusion] We conclude that the hold relax-agonist contraction technique may be beneficial for improving muscle activation and decreasing muscle fatigue.

  9. Branched-Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College-Age Females

    Science.gov (United States)

    Leahy, Danielle T.; Pintauro, Stephen J.

    2013-01-01

    Supplementation with branched-chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA (n = 10) or placebo (n = 10) groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (P = 0.018). No significant effect of BCAA supplementation versus placebo was noted in male subjects nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects. PMID:24967261

  10. To Compare the Effect of Vibration Therapy and Massage in Prevention of Delayed Onset Muscle Soreness (DOMS).

    Science.gov (United States)

    Imtiyaz, Shagufta; Veqar, Zubia; Shareef, M Y

    2014-01-01

    To compare the effects of vibration therapy and massage in prevention of DOMS. Pre-test and Post-test Control-Group Design was used, 45 healthy female non athletic Subjects were recruited and randomly distributed to the three groups (15 subject in each group). After the subject's initial status was measured experimental groups received vibration therapy (50 Hz vibration for five minutes) or massage therapy (15 minutes) intervention and control group received no treatment, just prior to the eccentric exercise. Subjects were undergoing the following measurements to evaluate the changes in the muscle condition: muscle soreness (pain perception), Range of Motion (ROM), Maximum Isometric Force (MIF), Repetition maximum (RM), Lactate dehydrogenase (LDH) and Cretain Kinase (CK) level. All the parameters except LDH, CK and 1RM were measured before, immediately post intervention, immediately post exercise, 24 hours post exercise, 48 hours post exercise and 72 hours post exercise. LDH, CK and 1 RM were measured before and 48 hours post exercise. Muscle soreness was reported to be significantly less for experimental (vibration and massage) group (p=0.000) as compared to control group at 24, 48, and 72 hours of post-exercise. Experimental and control group did not show any significant difference in MIF immediate (p=0.2898), 24 hours (p=0.4173), 48 hours (p=0.752) and 72 hours (p=0.5297) of post-exercise. Range of motion demonstrated significant recovery in experimental groups in 48 hours (p=0.0016) and 72 hours (p=0.0463). Massage therapy showed significant recovery in 1RM (p=0.000) compared to control group and vibration therapy shows significantly less LDH level (p=0.000) 48 hours of post exercise compare to control group. CK at 48 hours of post exercise in vibration group (p=0.000) and massage group showed (p=0.002) significant difference as compared to control group. Vibration therapy and massage are equally effective in prevention of DOMS. Massage is effective in

  11. Factors in delayed onset muscular soreness of man.

    Science.gov (United States)

    Bobbert, M F; Hollander, A P; Huijing, P A

    1986-02-01

    In this study 11 subjects performed exercise resulting in delayed onset muscular soreness in m. gastrocnemius with one leg, the experimental leg. The other leg served as control. Pre-exercise and 24, 48 and 72 h postexercise, soreness perception, resting EMG level of m. gastrocnemius, and volume and skin temperature of both legs were measured, and a leukocyte count was performed. Perception of soreness in m. gastrocnemius reported 24, 48, and 72 h postexercise was not accompanied by an increase in resting EMG level. This result indicates that soreness perception is not related to a tonic localized spasm in sore muscles. A rise in volume of the experimental leg relative to volume of the control leg was found 24, 48, and 72 h postexercise (P less than 0.05). It is suggested that the volume rise is due to edema formation in the experimental leg and that this edema formation is responsible for soreness perception. Since granulocytosis was not found, the hypothesis that edema formation reflects muscle inflammation is not substantiated.

  12. The Research Process of Delayed Onset Muscle Soreness%延迟性肌肉酸痛症的研究进展

    Institute of Scientific and Technical Information of China (English)

    蒋全睿; 艾坤; 刘小卫; 李江山; 李武

    2016-01-01

    通过查阅中国知网、PubMed等数据库,总结延迟性肌肉酸痛症(DOMS)的机制假说、常用治疗方法等;通过比较分析,总结相关机制研究和治疗方案,为延迟性肌肉酸痛症的研究提供参考。%By referring to databases such as CNKI and PubMed, to summarize the mechanism hypothesis and treatment methods of delayed onset muscle soreness (DOMS);Through comparative analysis, summarizes the related mechanism researches and therapeutic regimens, to provide refer-ences for researches of DOMS.

  13. A greater reduction of anterior cruciate ligament elasticity in women compared to men as a result of delayed onset muscle soreness.

    Science.gov (United States)

    Lee, Haneul; Petrofsky, Jerrold S; Laymon, Michael; Yim, JongEun

    2013-01-01

    Women have a higher risk for anterior cruciate ligament (ACL) injuries compared to men. ACL elasticity and muscle flexibility are major risk factors for knee injuries. The presence of estrogen receptors in connective tissue allows estrogen to change the mechanical properties of muscles and ligaments. Delayed onset muscle soreness (DOMS) happened when begin unaccustomed levels of exercise. Thus, the purpose of this study was to examine ACL elasticity after exercise meant to produce DOMS. As a measure of DOMS, visual analog pain scale and quadriceps strength were measured. One hundred forty healthy students (age: 25.2 ± 2.4 years, height: 165.9 ± 8.0 cm, weight: 62.5 ± 10.5 kg, BMI: 22.6 ± 3.1) participated in this investigation and were divided into two groups: men (n = 70) and women (n = 70). Visual analog pain scale, ACL elasticity, and quadriceps strength were measured before and after the intervention. Subjects participated in the same exercise to induce DOMS. To provoke DOMS, subjects accomplished squats for 5 minutes for 3 rounds. Greater ACL elasticity, greater pain on the subjective pain scale and less muscle strength were found (p damage to the ACL and recover slower compared to men after exercise. Thus, we suggest that women should have more time for musculoskeletal recovery after heavy exercise.

  14. Effect of Transcutaneous Electrical Nerve Stimulation, Cold, and a Combination Treatment on Pain, Decreased Range of Motion, and Strength Loss Associated with Delayed Onset Muscle Soreness

    Science.gov (United States)

    Denegar, Craig R.; Perrin, David H.

    1992-01-01

    Athletic trainers have a variety of therapeutic agents at their disposal to treat musculoskeletal pain, but little objective evidence exists of the efficacy of the modalities they use. In this study, delayed onset muscle soreness (DOMS) served as a model for musculoskeletal injury in order to: (1) compare the changes in perceived pain, elbow extension range of motion, and strength loss in subjects experiencing DOMS in the elbow flexor muscle group following a single treatment with either transcutaneous electrical nerve stimulation (TENS), cold, a combination of TENS and cold, sham TENS, or 20 minutes of rest; (2) compare the effects of combining static stretching with these treatments; and (3) determine if decreased pain is accompanied by a restoration of strength. DOMS was induced in the non-dominant elbow flexor muscle group in 40 females (age = 22.0 ± 4.3 yr) with repeated eccentric contractions. Forty-eight hours following exercise, all subjects presented with pain, decreased elbow extension range of motion, and decreased strength consistent with DOMS. Subjects were randomly assigned to 20-minute treatments followed by static stretching. Cold, TENS, and the combined treatment resulted in significant decreases in perceived pain. Treatments with cold resulted in a significant increase in elbow extension range of motion. Static stretching also significantly reduced perceived pain. Only small, nonsignificant changes in muscle strength were observed following treatment or stretching, regardless of the treatment group. These results suggest that the muscle weakness associated with DOMS is not the result of inhibition caused by pain. The results suggest that these modalities are effective in treating the pain and muscle spasm associated with DOMS, and that decreased pain may not be an accurate indicator of the recovery of muscle strength. PMID:16558162

  15. Eccentric exercise and delayed onset muscle soreness of the quadriceps induce adjustments in agonist-antagonist activity, which are dependent on the motor task.

    Science.gov (United States)

    Vila-Chã, C; Hassanlouei, H; Farina, D; Falla, D

    2012-02-01

    This study investigates the effects of eccentric exercise and delayed onset muscle soreness (DOMS) of the quadriceps on agonist-antagonist activity during a range of motor tasks. Ten healthy volunteers (age, mean ± SD, 24.9 ± 3.2 years) performed maximum voluntary contractions (MVC) and explosive isometric contractions of the knee extensors followed by isometric contractions at 2.5, 5, 10, 15, 20, and 30% MVC at baseline, immediately after and 24 h after eccentric exercise of the quadriceps. During each task, force of the knee extensors and surface EMG of the vasti and hamstrings muscles were recorded concurrently. Rate of force development (RFD) was computed from the explosive isometric contraction, and the coefficient of variation of the force (CoV) signal was estimated from the submaximal contractions. Twenty-four hours after exercise, the subjects rated their perceived pain intensity as 4.1 ± 1.2 (score out of 10). The maximum RFD and MVC of the knee extensors was reduced immediately post- and 24 h after eccentric exercise compared to baseline (average across both time points: 19.1 ± 17.1% and 11.9 ± 9.8% lower, respectively, P eccentric exercise (up to 66% higher than baseline, P exercise during the presence of DOMS (P exercise and was accompanied by increased antagonist EMG for the explosive contraction only. On the contrary, reduced force steadiness was accompanied by a general increase in EMG amplitude of the vasti muscles and was accompanied by increased antagonist activity, but only at higher force levels (>15% MVC). This study shows that eccentric exercise and subsequent DOMS of the quadriceps reduce the maximal force, rate of force development and force steadiness of the knee extensors, and is accompanied by different adjustments of agonist and antagonist muscle activities.

  16. Time course of muscle soreness following different types of exercise

    Directory of Open Access Journals (Sweden)

    Vickers Andrew J

    2001-10-01

    Full Text Available Abstract Background Post-exercise muscle soreness is a dull, aching sensation that follows unaccustomed muscular exertion. Primarily on the basis of previous laboratory-based research on eccentric exercise, soreness is usually said to follow an inverted U-shaped curve over time, peaking 24 – 48 hours after exercise. As such, it is often described as "delayed-onset" muscle soreness. In a study of long-distance runners, soreness seemed to peak immediately and then reduce gradually over time. The study is a secondary analysis of clinical trial data that aims to determine whether the time course of soreness following a natural exercise, long-distance running, is different from that following a laboratory-based exercise, bench-stepping. Methods This is a reanalysis of data from three previous clinical trials. The trials included 400 runners taking part in long-distance races and 82 untrained volunteers performing a bench-stepping test. Subjects completed a Likert scale of muscle soreness every morning and evening for the five days following their exercise. Results Interaction between trial and time is highly significant, suggesting a different time course of soreness following running and bench-stepping. 45% of subjects in the bench-stepping trial experienced peak soreness at the third or fourth follow-up (approximately 36 – 48 hours after exercise compared to only 14% of those in the running trial. The difference between groups is robust to multivariate analysis incorporating possible confounding variables. Conclusion Soreness in runners following long-distance running follows a different time course to that in untrained individuals undertaking bench-stepping. Research on exercise taking place in the laboratory context does not necessarily generalize to exercise undertaken by trained athletes when engaged in their chosen sport.

  17. Time course of muscle soreness following different types of exercise

    Science.gov (United States)

    Vickers, Andrew J

    2001-01-01

    Background Post-exercise muscle soreness is a dull, aching sensation that follows unaccustomed muscular exertion. Primarily on the basis of previous laboratory-based research on eccentric exercise, soreness is usually said to follow an inverted U-shaped curve over time, peaking 24 – 48 hours after exercise. As such, it is often described as "delayed-onset" muscle soreness. In a study of long-distance runners, soreness seemed to peak immediately and then reduce gradually over time. The study is a secondary analysis of clinical trial data that aims to determine whether the time course of soreness following a natural exercise, long-distance running, is different from that following a laboratory-based exercise, bench-stepping. Methods This is a reanalysis of data from three previous clinical trials. The trials included 400 runners taking part in long-distance races and 82 untrained volunteers performing a bench-stepping test. Subjects completed a Likert scale of muscle soreness every morning and evening for the five days following their exercise. Results Interaction between trial and time is highly significant, suggesting a different time course of soreness following running and bench-stepping. 45% of subjects in the bench-stepping trial experienced peak soreness at the third or fourth follow-up (approximately 36 – 48 hours after exercise) compared to only 14% of those in the running trial. The difference between groups is robust to multivariate analysis incorporating possible confounding variables. Conclusion Soreness in runners following long-distance running follows a different time course to that in untrained individuals undertaking bench-stepping. Research on exercise taking place in the laboratory context does not necessarily generalize to exercise undertaken by trained athletes when engaged in their chosen sport. PMID:11701094

  18. Biopsychosocial Influence on Exercise-induced Delayed Onset Muscle Soreness at the Shoulder: Pain Catastrophizing and Catechol-O-Methyltransferase (COMT) Diplotype Predict Pain Ratings

    Science.gov (United States)

    George, Steven Z.; Dover, Geoffrey C.; Wallace, Margaret R.; Sack, Brandon K.; Herbstman, Deborah M.; Aydog, Ece; Fillingim, Roger B.

    2009-01-01

    Objective The experience of pain is believed to be influenced by psychologic and genetic factors. A previous study suggested pain catastrophizing and catechol-O-methyltransferase (COMT) genotype influenced clinical pain ratings for patients seeking operative treatment of shoulder pain. This study investigated whether these same psychologic and genetic factors predicted responses to induced shoulder pain. Methods Participants (n=63) completed self-report questionnaires and had COMT genotype determined before performing a standardized fatigue protocol to induce delayed onset muscle soreness. Then, shoulder pain ratings, self-report of upper-extremity disability ratings, and muscle torque production were reassessed 24, 48, and 72 hours later. Results This cohort consisted of 35 women and 28 men, with a mean age of 20.9 years (SD=1.7). The frequency of COMT diplotypes was 42 with “high COMT enzyme activity” (low pain sensitivity group) and 21 with “low COMT enzyme activity” (average pain sensitivity/high pain sensitivity group). A hierarchical regression model indicated that an interaction between pain catastrophizing and COMT diplotype was the strongest unique predictor of 72-hour pain ratings. The same interaction was not predictive of self-report of disability or muscle torque production at 72 hours. The pain catastrophizing × COMT diplotype interaction indicated that participants with high pain catastrophizing and low COMT enzyme activity (average pain sensitivity/high pain sensitivity group) were more likely (relative risk=3.5, P=0.025) to have elevated pain intensity ratings (40/100 or higher). Discussion These findings from an experimental model converge with those from a surgical cohort and provide additional evidence that the presence of elevated pain catastrophizing and COMT diplotype indicative of low COMT enzyme activity have the potential to increase the risk of developing chronic pain syndromes. PMID:18936597

  19. The effect of pulsating electrostatic field application on the development of delayed onset of muscle soreness (DOMS) symptoms after eccentric exercise.

    Science.gov (United States)

    Gatterer, Hannes; Peters, Philippe; Philippe, Marc; Burtscher, Martin

    2015-10-01

    [Purpose] The aim of the study was to establish whether pulsating electrostatic field application, shown to increase blood flow and metabolic activity and to function as an ion pump, is able to reduce muscle pain after exercise-induced muscle damage. [Subjects and Methods] Seven participants (4 males, 3 females) performed two sessions of downhill running separated by at least 4 weeks. After the running sessions, participants were either treated for 45 min with a pulsating electrostatic field (field intensity, 9000 V; current, <9 mA; frequency, 50 Hz) or a sham treatment. The order of the intervention was random, and the condition was blinded for the participants. Muscle soreness score, creatine kinase, and jump ability were assessed before and up to 48 hours after running. [Results] Twenty-four and 48 hours after the downhill running, the muscle soreness score tended to be less increased after pulsating electrostatic field administration when compared with the sham setting (changes in muscle soreness score: 3.7±1.6 vs. 5.7±2.2 after 24 h and 3.1±2.0 vs. 5.4±3.2 after 48 h, respectively). No further differences were detected. [Conclusion] The outcomes show that a pulsating electrostatic field might be a promising treatment to reduce muscle soreness after exercise-induced muscle damage. However, further studies are needed to confirm the present outcomes and to establish the mechanism by which a pulsating electrostatic field may reduce muscle pain.

  20. Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial.

    Science.gov (United States)

    Fleckenstein, Johannes; Friton, Mara; Himmelreich, Heiko; Banzer, Winfried

    2017-05-01

    To examine the effects of a single administration of focused extracorporeal shock wave therapy on eccentric exercise-induced delayed-onset muscle soreness (DOMS). Three-arm randomized controlled study. University research center. Participants (N=46; 23 women) had a mean age of 29.0±3.0 years and a mean body mass index of 23.8±2.8kg/m(2). Participants were randomly allocated to verum- (energy flux density, .06-.09mJ/mm(2); pulse ratio per point, 200) or sham-focused extracorporeal shock wave therapy (no energy) at 7 equidistant points along the biceps muscle or no intervention. The primary outcome was the difference in pain intensity. Secondary outcomes included maximum isometric voluntary force (MIVF), pressure pain threshold (PPT), and impairment in daily life. Despite descriptive clinically meaningful differences, mixed-effects analysis (group × time) of changes to baseline did not reveal significant differences in the reduction of pain intensity between groups (F2,42=2.5, P=.094). MIVF was not significantly different between groups (F2,43=1.9, P=.159). PTT (F2,43=0.2, P=.854) and daily life impairment (F2,42=1.4, P=.248) were not significantly decreased over time, and there were no differences between groups in the post hoc analysis. DOMS is a common symptom in people participating in exercise, sports, or recreational physical activities. A single treatment with focused extracorporeal shock wave therapy causes clinically relevant effects in the relief of pain, increase in force, and improvement of pain-associated impairments of daily living. Still, results need to be cautiously interpreted because of the pilot character of this study. Focused extracorporeal shock wave therapy might present an option in the midterm recovery from DOMS (72h) and be an approach to enhance the return to play in athletes. Copyright © 2017. Published by Elsevier Inc.

  1. 延迟性肌肉酸痛实验模型及年龄特征分析%Delayed Onset Muscle Soreness Experimental Models and Age Characteristics

    Institute of Scientific and Technical Information of China (English)

    赵丽; 韩鹏; 张国强; 张翔

    2016-01-01

    研究目的:延迟性肌肉酸痛实验模型设计是其研究的重要组成部分而实验对象年龄也是延迟性肌肉酸痛的影响因素之一,探讨延迟性肌肉酸痛实验模型设计及实验对象的年龄特征,建立更便捷有效的延迟性肌肉酸痛实验模型。研究方法:文献资料法。结果与结论:1)成年人作为研究对象,能承受相对强度较大的运动,实验数据相对稳定,更有利于实验的进行;延迟性肌肉酸痛对老年人骨骼肌是否具有重塑的作用,还有待进一步研究。2)建议以人体的非惯用肢体大强度离心运动为主诱导延迟性肌肉酸痛的实验模型。3)延迟性肌肉酸痛的模型基本基于肢体进行不同负荷、形式的改变进行研究。建议选取可行性较高,操作简单且人为干预较少,诱导酸痛明显的方法,如:纵跳、斜面提踵、负重肘屈伸。4)疼痛识别可采用直观的视觉模拟量表。%Objective: Delayed Onset Muscle Soreness experimental model design is an important part of their research subjects and the age is one of the influence factors DOMS. To explore the experimental model of DOMS and the age characteristics of the experimental subjects, and to establish a more convenient and effective experimental model of DOMS. Methods: To retrieve in February 1984 to December 2015 Pub Med database related literature, the Chinese retrieval words:延迟性肌肉酸痛; The key words in English:Delayed Onset Muscle Soreness; Into the 138 paper, all the data of the related to this research and analysis. Results and conclusion: 1) As the research object, adults can bear larger relative intensity of sports, the experimental data is relatively stable, more conducive to the experiment;DOMS for the elderly skeletal muscle is reshaping the role, and it remains to be further research. 2) A proposal to the body of the non-dominant limb strength of large centrifugal movement induced experimental model

  2. Effect of low-level phototherapy on delayed onset muscle soreness: a systematic review and meta-analysis.

    Science.gov (United States)

    Nampo, Fernando Kenji; Cavalheri, Vinícius; Ramos, Solange de Paula; Camargo, Enilton Aparecido

    2016-01-01

    To determine the effectiveness of low-level phototherapy (i.e. light-emitting diode therapy [LEDtherapy] or light amplification by stimulated emission of radiation therapy [LASERtherapy]) on pain, skeletal muscle injury (creatine kinase [CK] levels and edema) and skeletal muscle function (range of movement and strength) in people undergoing an exercise protocol. (Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PEDro, SciELO and LILACS up to May 2014), we included randomized controlled trials, quasi-randomized controlled trials and crossover studies in which study participants were allocated to receive either low-level phototherapy or placebo treatment. Phototherapy should have been applied in a single treatment session, either before or after an exercise protocol. We identified 15 studies involving 317 participants. Meta-analyses were limited by substantial heterogeneity. Compared to the placebo group, reduction in CK levels was only observed when LASERtherapy was applied before an exercise protocol (standardized mean difference = -0.66; 95 % CI = -1.30, -0.02). No between-group difference in edema, range of movement and strength were detected when phototherapy was applied before or after exercise. Evidence from this review suggests that low-level phototherapy may not have substantial effect in the treatment of skeletal muscle injury and pain caused by exercise. Definitive conclusions are limited due to the small number of included studies in each meta-analysis, disparities across the included studies and small sample sizes.

  3. Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage.

    Science.gov (United States)

    Donnelly, A E; Maughan, R J; Whiting, P H

    1990-01-01

    Thirty-two volunteers participated in a two-period crossover study in which ibuprofen was tested against an identical placebo for its effectiveness in reducing muscle soreness and damage after two bouts of downhill running. Subjective soreness, quadriceps isometric strength and isometric endurance time at 50 percent of maximum strength, serum activities of creatine kinase, lactate dehydrogenase and aspartate transaminase and serum levels of creatinine and urea were recorded at intervals up to 72 hours after exercise. Each downhill run produced muscle soreness, and a decline in muscle strength and 50 percent endurance time, although these parameters were unaffected by ibuprofen treatment. All serum parameters measured increased after both runs, but for the three enzymes this increase was smaller after the second run. Serum creatine kinase and urea levels were higher in the ibuprofen group after both runs. These results indicate that ibuprofen is not an appropriate treatment for delayed onset muscle soreness and damage. PMID:2078806

  4. Exercise-induced muscle pain, soreness, and cramps.

    Science.gov (United States)

    Miles, M P; Clarkson, P M

    1994-09-01

    The three types of pain related to exercise are 1) pain experienced during or immediately following exercise, 2) delayed onset muscle soreness, and 3) pain induced by muscle cramps. Each is characterized by a different time course and different etiology. Pain perceived during exercise is considered to result from a combination of factors including acids, ions, proteins, and hormones. Although it is commonly believed that lactic acid is responsible for this pain, evidence suggests that it is not the only factor. However, no single factor has ever been identified. Delayed onset muscle soreness develops 24-48 hours after strenuous exercise biased toward eccentric (muscle lengthening) muscle actions or strenuous endurance events like a marathon. Soreness is accompanied by a prolonged strength loss, a reduced range of motion, and elevated levels of creatine kinase in the blood. These are taken as indirect indicators of muscle damage, and biopsy analysis has documented damage to the contractile elements. The exact cause of the soreness response is not known but thought to involve an inflammatory reaction to the damage. Muscle cramps are sudden, intense, electrically active contractions elicited by motor neuron hyperexcitability. Although it is commonly assumed that cramps during exercise are the result of fluid electrolyte imbalance induced by sweating, two studies have not supported this. Moreover, participants in occupations that require chronic use of a muscle but do not elicit profuse sweating, such as musicians, often experience cramps. Fluid electrolyte imbalance may cause cramps if there is profuse prolonged sweating such as that found in working in a hot environment. Thus, despite the common occurrence of pain associated with exercise, the exact cause of these pains remains a mystery.

  5. Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins.

    Science.gov (United States)

    Ferraresi, Cleber; Bertucci, Danilo; Schiavinato, Josiane; Reiff, Rodrigo; Araújo, Amélia; Panepucci, Rodrigo; Matheucci, Euclides; Cunha, Anderson Ferreira; Arakelian, Vivian Maria; Hamblin, Michael R; Parizotto, Nivaldo; Bagnato, Vanderlei

    2016-10-01

    The aim of this study was to verify how a pair of monozygotic twins would respond to light-emitting diode therapy (LEDT) or placebo combined with a strength-training program during 12 weeks. This case-control study enrolled a pair of male monozygotic twins, allocated randomly to LEDT or placebo therapies. Light-emitting diode therapy or placebo was applied from a flexible light-emitting diode array (λ = 850 nm, total energy = 75 J, t = 15 seconds) to both quadriceps femoris muscles of each twin immediately after each strength training session (3 times/wk for 12 weeks) consisting of leg press and leg extension exercises with load of 80% and 50% of the 1-repetition maximum test, respectively. Muscle biopsies, magnetic resonance imaging, maximal load, and fatigue resistance tests were conducted before and after the training program to assess gene expression, muscle hypertrophy and performance, respectively. Creatine kinase levels in blood and visual analog scale assessed muscle damage and delayed-onset muscle soreness, respectively, during the training program. Compared with placebo, LEDT increased the maximal load in exercise and reduced fatigue, creatine kinase, and visual analog scale. Gene expression analyses showed decreases in markers of inflammation (interleukin 1β) and muscle atrophy (myostatin) with LEDT. Protein synthesis (mammalian target of rapamycin) and oxidative stress defense (SOD2 [mitochondrial superoxide dismutase]) were up-regulated with LEDT, together with increases in thigh muscle hypertrophy. Light-emitting diode therapy can be useful to reduce muscle damage, pain, and atrophy, as well as to increase muscle mass, recovery, and athletic performance in rehabilitation programs and sports medicine.

  6. Effects of the homeopathic remedy arnica on attenuating symptoms of exercise-induced muscle soreness

    Science.gov (United States)

    Plezbert, Julie A.; Burke, Jeanmarie R.

    2005-01-01

    Abstract Objective To evaluate the clinical efficacy of Arnica at a high potency (200c), on moderating delayed onset muscle soreness and accompanying symptoms of muscle dysfunction. Methods Twenty subjects completed a maximal eccentric exercise protocol with the non-dominate elbow flexors to induce delayed onset muscle soreness. Either Arnica or placebo tablets were administered in a random, double- blinded fashion immediately after exercise and at 24 hours and 72 hours after exercise. Before exercise, immediately post-exercise, and at 24, 48, 72, and 96 hours post-exercise, assessments of delayed onset muscle soreness and muscle function included: 1) muscle soreness and functional impairment; 2) maximum voluntary contraction torque; 3) muscle swelling; and 4) range of motion tests to document spontaneous muscle shortening and muscle shortening ability. Blood samples drawn before exercise and at 24, 48, and 96 hours after exercise were used to measure muscle enzymes as indirect indices of muscle damage. Results Regardless of the intervention, the extent of delayed onset muscle soreness and elevations in muscle enzymes were similar on the days following the eccentric exercise protocol. The post-exercise time profiles of decreases in maximum voluntary contraction torque and muscle shortening ability and increases in muscle swelling and spontaneous muscle shortening were similar for each treatment intervention. Conclusions The results of this study did not substantiate the clinical efficacy of Arnica at a high potency on moderating delayed onset muscle soreness and accompanying symptoms of muscle dysfunction. Despite the findings of this study, future investigations on the clinical efficacy of homeopathic interventions should consider incorporating research strategies that emphasize differential therapeutics for each patient rather than treating a specific disease or symptom complex, such as DOMS, with a single homeopathic remedy. PMID:19674657

  7. 肌肉延迟性酸痛的神经生物学机制研究进展%Reearch progresses of the neurobiology mechanism of delayed onset muscle soreness

    Institute of Scientific and Technical Information of China (English)

    王军; 赵晏

    2008-01-01

    肌肉延迟性酸痛(delayed onset muscle soreness, DOMS)是生活中经常遇到的一种现象,由于其发生机制尚不十分清楚,并缺乏可靠的防治措施,一直成为运动医学界的重要话题.本文总结了近年来有关DOMS发生机制方面的研究成果,着重从神经生物学角度来探讨和分析DOMS的产生原因.

  8. Cold-water immersion versus passive therapy to decrease delayed onset muscular soreness: a CAT

    Directory of Open Access Journals (Sweden)

    Raúl Alberto Aguilera Eguía

    2014-06-01

    Full Text Available Introduction Late onset muscle soreness, also known as delayed onset muscle soreness, is a painful musculoskeletal condition that may occur 24-48 and up to 72 hours after the completion of unusual physical or high intensity exercise involving eccentric muscle activity. In the field of physical rehabilitation, immersion in cold water is a common intervention mainly used in sports medicine, to minimize delayed onset muscle soreness and promote recovery after exercise. Objective To assess the validity and applicability of the results regarding the effectiveness of immersion in cold water after high intensity exercise and answer the following question: In subjects who exercise regularly, can cold-water immersion compared to passive therapy (rest reduce late-onset muscle soreness? Methods The article "Cold Water Immersion (cryotherapy for preventing and treating muscle soreness after exercise," a Cochrane systematic review authored by Bleakley et al (2012, was analyzed. Results Immersion in cold water can decrease delayed onset of muscle pain after high intensity exercise. Twenty-four hours after the intervention, the mean standardized difference was -0.55 (95% CI: -0.84 to -0.27; 48 hours after, the mean standardized difference was -0.66 (95% CI: -0.97 to -0.35; 72 hours after, the mean standardized difference was -0.93 (95% CI: -1.36 to -0.51 and up to 96 hours after, mean standardized difference was -0.58 (95% CI: -1.00 to -0.16. Conclusion Despite the methodological limitations present in the studies included in the systematic review analyzed, we found the recommendation for cold water immersion (cryotherapy reasonable in individuals with late muscle pain caused by high intensity sports.

  9. Potential Linkage of Satellite Cells and Delayed Onset Muscle Soreness%肌卫星细胞与延迟性肌肉酸痛的潜在联系

    Institute of Scientific and Technical Information of China (English)

    赵新娟; 杜海平; 王植元; 张翔

    2015-01-01

    By reviewing related literatures retrieved through the CNKI and Pubmed database. the continuous intensive eccentric exercise may have certain regulation to skeletal muscle satellite cell growth factor which is closely related to repair skeletal muscle damage ; delayed onset muscle soreness sequential timing has certain correlation with skeletal muscle satellite cell proliferation; delayed ache of skeletal muscle special micro environment certain extent to stimulate the secretion of skeletal muscle satellite cell growth factor and promote skeletal muscle sarcomere remodeling.%检索中国知网和Pubmed数据库中相关文献并对其进行综述。持续大强度离心运动可能对与骨骼肌损伤修复密切相关的骨骼肌卫星细胞生长因子具有一定的调节作用;持续大强度离心运动引发的延迟性肌肉酸痛的发生时序与骨骼肌卫星细胞增殖时序存在一定的相关性;延迟性酸痛的骨骼肌特殊微环境一定程度上刺激骨骼肌卫星细胞生长因子的分泌,促进骨骼肌肌节重塑。

  10. Effects of whole-body vibration after eccentric exercise on muscle soreness and muscle strength recovery.

    Science.gov (United States)

    Timon, Rafael; Tejero, Javier; Brazo-Sayavera, Javier; Crespo, Carmen; Olcina, Guillermo

    2016-06-01

    [Purpose] The aim of this study was to investigate whether or not a single whole-body vibration treatment after eccentric exercise can reduce muscle soreness and enhance muscle recovery. [Subjects and Methods] Twenty untrained participants were randomly assigned to two groups: a vibration group (n=10) and control group (n=10). Participants performed eccentric quadriceps training of 4 sets of 5 repetitions at 120% 1RM, with 4 min rest between sets. After that, the vibration group received 3 sets of 1 min whole body vibration (12 Hz, 4 mm) with 30 s of passive recovery between sets. Serum creatine kinase, blood urea nitrogen, muscle soreness (visual analog scale) and muscle strength (peak isometric torque) were assessed. [Results] Creatine kinase was lower in the vibration group than in the control group at 24 h (200.2 ± 8.2 vs. 300.5 ± 26.1 U/L) and at 48 h (175.2 ± 12.5 vs. 285.2 ± 19.7 U/L) post-exercise. Muscle soreness decreased in vibration group compared to control group at 48 h post-exercise (34.1 ± 11.4 vs. 65.2 ± 13.2 mm). [Conclusion] Single whole-body vibration treatment after eccentric exercise reduced delayed onset muscle soreness but it did not affect muscle strength recovery.

  11. Does Postexercise Static Stretching Alleviate Delayed Muscle Soreness?

    Science.gov (United States)

    Buroker, Katherine C.; Schwane, James A.

    1989-01-01

    Because many experts recommend stretching after exercise to relieve muscle soreness, 23 subjects performed a 30-minute step test to induce delayed muscle soreness. There was neither temporary relief of pain immediately after stretching nor a reduction in pain during the 3-day postexercise period. (Author/SM)

  12. Can Muscle Soreness After Intensive Work-related Activities Be Predicted?

    NARCIS (Netherlands)

    Soer, Remko; Geertzen, Jan H. B.; van der Schans, Cees P.; Groothoff, Johan W.; Reneman, Michiel F.

    2009-01-01

    Objectives: It is currently unknown whether specific determinants are predictive for developing delayed onset muscle soreness (DOMS) after heavy work-related activities. The aim of this study was to analyze whether personal characteristics and performance measures are predictive for onset, intensity

  13. Effects of Fish Oil Supplementation on Postresistance Exercise Muscle Soreness.

    Science.gov (United States)

    Tinsley, Grant M; Gann, Joshua J; Huber, Stefan R; Andre, Thomas L; La Bounty, Paul M; Bowden, Rodney G; Gordon, Paul M; Grandjean, Peter W

    2016-07-21

    The aim of this study was to examine the effects of fish oil supplementation on the magnitude and time-course of postresistance exercise muscle soreness. This study was a randomized, placebo-controlled, double-blind trial. Nonresistance trained females were randomized into one of two groups: fish oil supplementation (6 g/day; 5:1 eicosapentaenoic acid to docosahexaenoic acid (EPA:DHA)) or placebo (6 g/day corn/soy oil). After consuming the supplements for one week, participants underwent a single bout of resistance exercise consisting of 10 sets to failure of elbow flexion and leg extension machines. Muscle soreness was measured daily over the next week via grounded visual analog scale while participants continued to consume their assigned supplement. At 48 hours and one week postexercise, soreness during functional movements and limb circumferences were measured. The fish oil group perceived less static and functional muscle soreness than placebo, although the differences were not statistically significant. Effect sizes for resistance exercise-induced static and functional soreness responses were 33 to 42% lower in fish oil versus placebo without changes in upper arm and thigh circumferences. Supplementing the diet with 6 g per day of fish oil may alleviate muscle soreness experienced after resistance training in young untrained females.

  14. 体针加中药对延迟性肌肉酸痛的治疗%The Acupuncture and Traditional Chinese Medicine on Treatment of Delayed Onset Muscle Soreness

    Institute of Scientific and Technical Information of China (English)

    李健隆; 翟鹏飞

    2006-01-01

      延迟性肌肉酸痛(Delayed Onset Muscle Soreness,DOMS)是运动员在运动训练过程中经常发生的现象.特别在突然加大运动量、非习惯性运动及力量训练后24h发生,主要表现为肌肉疼痛和(或)伴有肿胀、僵硬等症状.48h达到峰值随后逐渐减轻[1].该症状的发生对运动员的训练和比赛成绩的提高是一个巨大的障碍.常用的按摩、理疗、淋浴等疗法,效果欠佳.本研究应用体针和中药内调相结合的方法进行治疗,效果较为理想,对今后延迟性肌肉酸痛治疗具有一定的参考价值.……

  15. Can Muscle Soreness After Intensive Work-related Activities Be Predicted?

    OpenAIRE

    Soer, Remko; Jan H B Geertzen; van der Schans, Cees P; Johan W. Groothoff; Reneman, Michiel F

    2009-01-01

    Objectives: It is currently unknown whether specific determinants are predictive for developing delayed onset muscle soreness (DOMS) after heavy work-related activities. The aim of this study was to analyze whether personal characteristics and performance measures are predictive for onset, intensity, and duration of DOMS after performing work-related activities during a Functional Capacity Evaluation in healthy participants. Methods: Included in this study were 197 healthy participants (102 m...

  16. Modulation in voluntary neural drive in relation to muscle soreness

    OpenAIRE

    Racinais, S.; Bringard, A.; Puchaux, K.; Noakes, T D; Perrey, S.

    2007-01-01

    The aim of this study was to investigate whether (1) spinal modulation would change after non-exhausting eccentric exercise of the plantar flexor muscles that produced muscle soreness and (2) central modulation of the motor command would be linked to the development of muscle soreness. Ten healthy subjects volunteered to perform a single bout of backward downhill walking exercise (duration 30 min, velocity 1 ms−1, negative grade −25%, load 12% of body weight). Neuromuscular test sessions [H-r...

  17. Maximal force, voluntary activation and muscle soreness after eccentric damage to human elbow flexor muscles

    Science.gov (United States)

    Prasartwuth, O; Taylor, JL; Gandevia, SC

    2005-01-01

    Muscle damage reduces voluntary force after eccentric exercise but impaired neural drive to the muscle may also contribute. To determine whether the delayed-onset muscle soreness, which develops ∼1 day after exercise, reduces voluntary activation and to identify the possible site for any reduction, voluntary activation of elbow flexor muscles was examined with both motor cortex and motor nerve stimulation. We measured maximal voluntary isometric torque (MVC), twitch torque, muscle soreness and voluntary activation in eight subjects before, immediately after, 2 h after, 1, 2, 4 and 8 days after eccentric exercise. Motor nerve stimulation and motor cortex stimulation were used to derive twitch torques and measures of voluntary activation. Eccentric exercise immediately reduced the MVC by 38 ± 3% (mean ±s.d., n = 8). The resting twitch produced by motor nerve stimulation fell by 82 ± 6%, and the estimated resting twitch by cortical stimulation fell by 47 ± 15%. While voluntary torque recovered after 8 days, both measures of the resting twitch remained depressed. Muscle tenderness occurred 1–2 days after exercise, and pain during contractions on days 1–4, but changes in voluntary activation did not follow this time course. Voluntary activation assessed with nerve stimulation fell 19 ± 6% immediately after exercise but was not different from control values after 2 days. Voluntary activation assessed by motor cortex stimulation was unchanged by eccentric exercise. During MVCs, absolute increments in torque evoked by nerve and cortical stimulation behaved differently. Those to cortical stimulation decreased whereas those to nerve stimulation tended to increase. These findings suggest that reduced voluntary activation contributes to the early force loss after eccentric exercise, but that it is not due to muscle soreness. The impairment of voluntary activation to nerve stimulation but not motor cortical stimulation suggests that the activation deficit lies in the

  18. Acute effects of massage or active exercise in relieving muscle soreness: randomized controlled trial.

    Science.gov (United States)

    Andersen, Lars L; Jay, Kenneth; Andersen, Christoffer H; Jakobsen, Markus D; Sundstrup, Emil; Topp, Robert; Behm, David G

    2013-12-01

    Massage is commonly believed to be the best modality for relieving muscle soreness. However, actively warming up the muscles with exercise may be an effective alternative. The purpose of this study was to compare the acute effect of massage with active exercise for relieving muscle soreness. Twenty healthy female volunteers (mean age 32 years) participated in this examiner-blind randomized controlled trial (ClinicalTrials.gov NCT01478451). The participants performed eccentric contractions for the upper trapezius muscle on a Biodex dynamometer. Delayed onset muscle soreness (DOMS) presented 48 hours later, at which the participants (a) received 10 minutes of massage of the trapezius muscle or (b) performed 10 minutes of active exercise (shoulder shrugs 10 × 10 reps) with increasing elastic resistance (Thera-Band). First, 1 treatment was randomly applied to 1 shoulder while the contralateral shoulder served as a passive control. Two hours later, the contralateral resting shoulder received the other treatment. The participants rated the intensity of soreness (scale 0-10), and a blinded examiner took measures of pressure pain threshold (PPT) of the upper trapezius immediately before treatment and 0, 10, 20, and 60 minutes after treatment 48 hours posteccentric exercise. Immediately before treatment, the intensity of soreness was 5.0 (SD 2.2) and PPT was 138 (SD 78) kPa. In response to treatment, a significant treatment by time interaction was found for the intensity of soreness (p < 0.001) and PPT (p < 0.05). Compared with control, both active exercise and massage significantly reduced the intensity of soreness and increased PPT (i.e., reduced pain sensitivity). For both types of treatment, the greatest effect on perceived soreness occurred immediately after treatment, whereas the effect on PPT peaked 20 minutes after treatment. In conclusion, active exercise using elastic resistance provides similar acute relief of muscle soreness as compared with that using massage

  19. Uso do alongamento estático como fator interveniente na dor muscular de início tardio Use of static stretching as an intervenient factor in delayed onset muscle soreness

    Directory of Open Access Journals (Sweden)

    Aline Evans de Oliveira Bonfim

    2010-10-01

    Full Text Available INTRODUÇÃO: A dor muscular de início tardio consiste em uma sensação de desconforto muscular consequente da prática de exercício físico intenso, que perdura durante alguns dias. O alongamento estático pode ser usado para tentar amenizar esse efeito pós-exercício, mantendo-o durante cerca de 10-30 segundos e repetindo o procedimento por três a cinco vezes. OBJETIVO: Verificar, em indivíduos sedentários, o efeito do alongamento estático para o alívio da dor muscular de início tardio. MÉTODOS: Este estudo foi um ensaio clínico randomizado, prospectivo, cego por parte do avaliador, composto por 20 estudantes que foram divididos em dois grupos: GAL (exercício + alongamento e GC (exercício. O exercício foi constituído de cinco séries com 20 repetições de planti/dorsiflexão, exercitando o grupo tríceps sural. Ambos os grupos foram avaliados antes do exercício e reavaliados após 24, 48 e 72 horas, quanto ao seu grau de dor utilizando-se a escala visual analógica (VAS e um dolorímetro de pressão. RESULTADOS: A VAS mostrou que no grupo controle (GC houve diferença significativa na sensação de dor no pré-exercício comparado a 24, 48 e 72 horas, entre 24 e 72 horas e entre 48 e 72 horas após o exercício. No grupo alongamento (GAL, a VAS mostrou diferenças significativas no período pré-exercício comparado com 24, 48 e 72 horas e entre 48 e 72 horas após o exercício. O dolorímetro mostrou que no grupo controle (GC, houve diferença significativa na sensação de dor no pré-exercício comparado a 24 e 48 horas e entre 24 e 72 horas após o exercício. No grupo alongamento (GAL, as diferenças significativas se mostraram no período pré-exercício comparado com 24 e 48 horas após o mesmo. CONCLUSÃO: O alongamento estático não foi eficaz para o alívio da dor muscular de início tardio no grupo avaliado.INTRODUCTION: The Delayed Onset Muscle Soreness consists in a sensation of muscle discomfort resulting from

  20. EFFECT OF CAFFEINE ON THE AMOUNT OF PERCEIVED PAIN, JOINT RANGE OF MOTION AND EDEMA AFTER DELAYED MUSCLE SORENESS

    Directory of Open Access Journals (Sweden)

    Sara Karabalaeifar

    2013-01-01

    Full Text Available Delayed onset muscle soreness usually occurs after doing a new unusual physical activity, especially when, associated with repeated eccentric contractions and then it gradually disappears. There is not an extensive agreement in the case of treatment method of soreness signs quick reduction. This research was carried out with the aim of investigation caffeine consumption effect to find a good way in order to reduce the signs of delayed onset muscle soreness. In this semi-experimental with Double-blind design, 16 female volleyball player with an age average of 22.5+2.5 in 2 homogeneous 8 subject control and experimental group were studied. In this research, the effect of caffeine existing in coffee in 5 stages (24h before exercise, 12h before, immediately before exercise, after exercise and 12h after it and 1mg per 1kg of body weight on amount of perceived pain and range of motion of the joint and edema due to delay onset muscle soreness because of 50 jumps and lands of a 1 meter stage was investigated. The results showed that caffeine consumption has a meaningful effect on reduction of all the expressed signs after eccentric contractions. So it is recommended that physio thrapysts, doctors and athletes use this method to reduce delayed onset muscle soreness consequences after the injury.

  1. Establishing an animal model of delayed onset muscle soreness and its histomorphologic observation%延迟性肌肉酸痛动物模型的建立及组织形态学观察

    Institute of Scientific and Technical Information of China (English)

    魏源; 方春露; 李良鸣; 邢文华; 杨则宜

    2015-01-01

    背景:延迟性肌肉酸痛和骨骼肌微损伤有密切关系,但对于骨骼肌微损伤的确切机制还不太清楚。目的:通过离心运动建立骨骼肌微损伤模型,通过其组织形态学和超微结构变化。方法:将40只雄性 SD大鼠随机等分为安静对照组、运动后即刻组、运动后24 h组、运动后48 h组和运动后72 h组。后4组大鼠进行一次间歇性下坡跑运动,速度为16 m/min,坡度为-16°,5 min运动,2 min休息,共120 min。运动后即刻组、运动后24 h组、运动后48 h组和运动后72 h组大鼠分别于运动后即刻、24,48,72 h进行观察。结果与结论:离心运动后,大鼠骨骼肌组织形态结构和超微结构都发生了程度不同的变化,骨骼肌组织中结蛋白和波形蛋白出现不同程度的抗结蛋白抗体染色脱染。表明一次性离心运动能引起延迟性骨骼肌微损伤。%BACKGROUND:Delayed onset muscle soreness is closely related to skeletal muscle micro-injury, but the exact mechanism of skeletal muscle micro-injury is not yet clear. OBJECTIVE:To observe the histomorphological and ultrastructure changes of skeletal muscle micro-injury models induced by eccentric exercise. METHODS: Forty male Sprague-Dawley rats were randomly divided into quiet control group, immediately after exercise group, post-exercise 24 hours group, post-exercise 48 hours group and post-exercise 72 hours group. In the latter four groups, the rats were subjected to intermittent running on the-16° slope at a speed of 16 m/min: 5 minutes movement, 2 minutes rest and totaly 120 minutes. Rats in the latter four groups were observed immediately, at 24, 48, 72 hours after exercise. RESULTS AND CONCLUSION:After eccentric exercise, the morphology and ultrastructure of rat’s skeletal muscle were both changed to different extents, and Desmin and Vimentin were dyed off for anti-desmin antibody staining at varying degrees. It indicates that one

  2. Acute effects of massage or active exercise in relieving muscle soreness

    DEFF Research Database (Denmark)

    Andersen, Lars L; Jay, Kenneth; Andersen, Christoffer H

    2013-01-01

    healthy female volunteers (mean age 32 years) participated in this examiner-blind randomized controlled trial (ClinicalTrials.gov NCT01478451). The participants performed eccentric contractions for the upper trapezius muscle on a Biodex dynamometer. Delayed onset muscle soreness (DOMS) presented 48 hours...... later, at which the participants (a) received 10 minutes of massage of the trapezius muscle or (b) performed 10 minutes of active exercise (shoulder shrugs 10 × 10 reps) with increasing elastic resistance (Thera-Band). First, 1 treatment was randomly applied to 1 shoulder while the contralateral...... shoulder served as a passive control. Two hours later, the contralateral resting shoulder received the other treatment. The participants rated the intensity of soreness (scale 0-10), and a blinded examiner took measures of pressure pain threshold (PPT) of the upper trapezius immediately before treatment...

  3. Modulation in voluntary neural drive in relation to muscle soreness

    Science.gov (United States)

    Bringard, A.; Puchaux, K.; Noakes, T. D.; Perrey, S.

    2007-01-01

    The aim of this study was to investigate whether (1) spinal modulation would change after non-exhausting eccentric exercise of the plantar flexor muscles that produced muscle soreness and (2) central modulation of the motor command would be linked to the development of muscle soreness. Ten healthy subjects volunteered to perform a single bout of backward downhill walking exercise (duration 30 min, velocity 1 ms−1, negative grade −25%, load 12% of body weight). Neuromuscular test sessions [H-reflex, M-wave, maximal voluntary torque (MVT)] were performed before, immediately after, as well as 1–3 days after the exercise bout. Immediately after exercise there was a −15% decrease in MVT of the plantar flexors partly attributable to an alteration in contractile properties (−23% in electrically evoked mechanical twitch). However, MVT failed to recover before the third day whereas the contractile properties had significantly recovered within the first day. This delayed recovery of MVT was likely related to a decrement in voluntary muscle drive. The decrease in voluntary activation occurred in the absence of any variation in spinal modulation estimated from the H-reflex. Our findings suggest the development of a supraspinal modulation perhaps linked to the presence of muscle soreness. PMID:17978834

  4. Cochrane review: Whole-body cryotherapy (extreme cold air exposure) for preventing and treating muscle soreness after exercise in adults.

    Science.gov (United States)

    Costello, Joseph T; Baker, Philip Ra; Minett, Geoffrey M; Bieuzen, Francois; Stewart, Ian B; Bleakley, Chris

    2016-01-14

    Delayed-onset muscle soreness, or 'DOMS', affects many people after exercise and can impair future performance. It usually peaks one to four days after exercise and several strategies are used to overcome it. The effectiveness and safety of many of these strategies applied and promoted is unknown. This article is protected by copyright. All rights reserved.

  5. Efeito da massagem clássica na percepção subjetiva de dor, edema, amplitude articular e força máxima após dor muscular tardia induzida pelo exercício Effect of classical massage on subjective perceived soreness, edema, range of motion and maximum strength after delayed onset muscle soreness induced by exercise

    Directory of Open Access Journals (Sweden)

    César Cavinato Cal Abad

    2010-02-01

    Full Text Available O treino de força com cargas elevadas tem induzido indivíduos a apresentarem sintomas de dano muscular que incluem a dor muscular tardia. Na tentativa de diminuir sintomas e desconforto da DOMS, estratégias têm sido utilizadas, entre elas, a massagem. O objetivo do presente estudo foi verificar os efeitos da massagem clássica na percepção subjetiva de dor (DOMS, circunferência do braço (CIR, amplitude de movimento (ADM e força máxima (1RM após protocolo para indução de DOMS. Para isso, 18 adultos jovens saudáveis do gênero masculino foram divididos em três grupos (G1 = massagem; G2 = protocolo; G3 = protocolo + massagem equalizados pelo teste de uma força máxima de flexão de cotovelo no banco Scott. O protocolo de indução de DOMS consistiu de 30 ações excêntricas musculares supramáximas (seis séries de cinco repetições a 110% de 1RM. A massagem foi realizada no grupo G3 imediatamente após o protocolo durante seis minutos. As variáveis dependentes (DOMS, CIR, ADM foram avaliadas 24, 48, 72 e 96 horas após o protocolo, enquanto a força máxima, apenas após 48 e 96 horas. Os resultados indicaram aumento na DOMS e diminuição na ADM e 1RM, similar aos de outros estudos que utilizaram protocolos semelhantes. No entanto, não houve diferenças entre os grupos G2 e G3 em nenhuma das variáveis analisadas. Pode-se concluir que com esse design experimental o protocolo utilizado foi eficaz para provocar as alterações nas variáveis analisadas e a massagem não causou nenhum benefício na recuperação das funções musculares nem na percepção subjetiva de dor.Heavy resistance training induces to symptoms of muscle damage which include delayed onset muscle soreness (DOMS. Some strategies (i.e. massage have been used to attenuate these symptoms and to reduce discomfort associated with DOMS. This study aimed to investigate the effects of classical massage on DOMS perception, limb girth (CIR, range of motion (ADM and

  6. Effectiveness of using wearable vibration therapy to alleviate muscle soreness.

    Science.gov (United States)

    Cochrane, Darryl J

    2017-03-01

    To examine the acute and short-term effect of a wearable vibration device following strenuous eccentric exercise of the elbow flexors. Physically active males (n = 13) performed vibration therapy (VT) and control following eccentric exercise. The arms were randomised and counterbalanced, separated by 14 days. 15 min of VT (120 Hz) was applied immediately and 24, 48, and 72 h after eccentric exercise while the contralateral arm performed no VT (control). Muscle (isometric and concentric) strength, range of motion, electromyography (EMG), muscle soreness and creatine kinase were taken pre-exercise, immediately and 24, 48, and 72 h post-eccentric exercise. Additionally, the acute effect of VT of muscle strength, range of motion, EMG, muscle soreness was also investigated immediately after VT. In the short-term VT was able to significantly reduce the level of biceps brachii pain at 24 h (p motion at 24 h (p control. Acutely, following VT treatment muscle pain and range of motion significantly improved (p motion; however, there was no improvement of muscle strength recovery compared to control following eccentric exercise of the elbow flexors.

  7. Effects of stretching before and after exercising on muscle soreness and risk of injury: systematic review

    National Research Council Canada - National Science Library

    Herbert, Rob D; Gabriel, Michael

    2002-01-01

    Abstract Objective: To determine the effects of stretching before and after exercising on muscle soreness after exercise, risk of injury, and athletic performance. Method: Systematic review. Data sources...

  8. Convergent evidence for construct validity of a 7-point likert scale of lower limb muscle soreness.

    Science.gov (United States)

    Impellizzeri, Franco M; Maffiuletti, Nicola A

    2007-11-01

    The aim of this study was to examine the construct validity of the 7-point Likert scale of muscle soreness, assessing its relationship with Visual Analogue Scale (VAS). An additional aim was to examine its sensitivity as measure of symptom of eccentric-contraction muscle damage. Correlational study. Self-administered questionnaires collected in field setting. Twenty-six soccer players. 4-week preseason training camp, which included high-intensity plyometric training sessions. Players self-reported the perceived muscle soreness of the lower limbs using the VAS (criterion measure) and the 7-point Likert scale of muscle soreness. Significant individual correlations were found between the 2 muscle soreness scales (mean r=0.80+/-0.07; range, 0.65 to 0.94). The correlation using the pooled data was 0.81. No significant muscle soreness scale x time interaction was found for standardized measures of muscle soreness (P=0.98). The main factor for time (24, 48, 72, and 96 hours after the first plyometric training session) was significant (P=0.0001). Effect sizes for the changes in the Likert and VAS absolute scores during the first 96 hours were similar (partial eta=0.13). The results of this study provide further convergent evidence for the construct validity of the 7-point Likert scale of muscle soreness. The 2 scales showed similar sensitivity to muscle soreness caused by eccentric contractions during the first 96 hours after plyometric exercises.

  9. Muscle fascicle behavior during eccentric cycling and its relation to muscle soreness.

    Science.gov (United States)

    Peñailillo, Luis; Blazevich, Anthony J; Nosaka, Kazunori

    2015-04-01

    A single bout of eccentric exercise confers a protective effect against muscle damage and soreness in subsequent eccentric exercise bouts, but the mechanisms underpinning this effect are unclear. This study compared vastus lateralis (VL) muscle-tendon behavior between two eccentric cycling bouts to test the hypothesis that muscle-tendon behavior would be different between bouts and would be associated with the protective effect. Eleven untrained men (27.1 ± 7.0 yr) performed two bouts of eccentric cycling (ECC1 and ECC2) separated by 2 wk for 10 min at 65% of maximal concentric workload (191.9 ± 44.2 W) each. Muscle soreness (by visual analog scale) and maximal voluntary isometric contraction (MVC) torque of the knee extensors were assessed before and 1-2 d after exercise. Using ultrasonography, VL fascicle length and angle changes during cycling were assessed, and tendinous tissue (TT) length changes were estimated. VL EMG amplitude, crank torque, and knee joint angles were measured during cycling. Soreness was greater (P knee angles were evident between bouts. However, fascicle elongation was 16% less during ECC2 than ECC1 (P knee joint angle during ECC2 than ECC1 (P = 0.055). These results suggest that a lesser fascicle elongation and earlier TT elongation were associated with reduced muscle soreness after ECC2 than ECC1; thus, changes in muscle-tendon behavior may be an important mechanism underpinning the protective effect.

  10. Supplementation with a polyphenolic blend improves post-exercise strength recovery and muscle soreness

    Directory of Open Access Journals (Sweden)

    Kelli A. Herrlinger

    2015-12-01

    Full Text Available Background: Exercise can initiate a cascade of inflammatory and oxidative stress–related events leading to delayed onset muscle soreness. Polyphenols possess antioxidant and anti-inflammatory properties. Objective: The current study examined the effects of a proprietary polyphenolic blend (PB, containing catechins and theaflavins, on exercise performance and recovery following an eccentric exercise challenge. Design: Male participants (18–35 years of age received placebo or PB at a low dose (PB-L, 1,000 mg/d or high dose (PB-H, 2,000 mg/d for 13 weeks. During the 13th week of supplementation, participants completed an eccentric exercise (40 min downhill treadmill run followed by a strength assessment (peak torque on isokinetic leg extensions pre-exercise, and 24, 48, and 96 h post-exercise. Muscle soreness (subjective questionnaire, markers of muscle stress (cortisol and creatine phosphokinase [CK], and antioxidant capacity (ferric reducing ability of plasma [FRAP] were also assessed. Results: PB-H attenuated the decrease in peak torque observed in the placebo group from pre-exercise to 48 h (p=0.012 and 96 h (p=0.003 post-exercise. At 48 h post-exercise, PB-H reduced whole body and hamstring soreness (p=0.029 versus placebo. Chronic consumption of PB improved serum FRAP (p=0.039. As expected, serum cortisol and CK increased from pre- to post-exercise in all groups; however, by 96 h, cortisol and CK levels returned to pre-exercise levels following PB supplementation. At 96 h, the change in cortisol from pre- to post-exercise was significantly greater in placebo versus PB-H (p=0.039. Conclusion: These findings show that chronic consumption of PB improved antioxidant status, reduced markers of muscle stress, and promoted strength recovery post-exercise.

  11. Stretching Before and After Exercise: Effect on Muscle Soreness and Injury Risk

    Science.gov (United States)

    Andersen, J. C

    2005-01-01

    Reference: Herbert RD, Gabriel M. Effects of stretching before and after exercise on muscle soreness and risk of injury: systematic review. BMJ. 2002;325:468. Clinical Question: Among physically active individuals, does stretching before and after exercise affect muscle soreness and risk of injury? Data Sources: Studies were identified by searching MEDLINE (1966–February 2000), EMBASE (1988–February 2000), CINAHL (1982–1999), SPORT Discus (1949–1999), and PEDro (to February 2000). I searched the reference lists of identified studies manually until no further studies were identified. The search terms stretch, exercise, warm-up, and cool down were used in all databases except MEDLINE. In MEDLINE, an optimized OVID search strategy was used. This strategy included the terms searched in the other databases as well as terms such as flexibility, athletic injuries, sports, soreness, and muscle. Study Selection: The search was limited to English-language articles obtained from the electronic searches and the subsequent manual searches. This review included randomized or quasirandomized investigations that studied the effects of any stretching technique, before or after exercise, on delayed-onset muscle soreness, risk of injury, or athletic performance. Studies were included only if stretching occurred immediately before or after exercising. Data Extraction: Data extraction and assessment of study quality were well described. The principal outcome measures were measurements of muscle soreness and indices of injury risk. Results from the soreness studies were pooled by converting the numeric scores to percentages of the maximum possible score. These data were then reported as millimeters on a 100-mm visual analogue scale. Results of comparable studies were pooled using a fixed-effects model meta-analysis. Survival analysis using a Cox regression model was calculated on the time-to-event (injury) data. Main Results: The total number of articles identified using the

  12. Effects of stretching before and after exercising on muscle soreness and risk of injury: systematic review

    Science.gov (United States)

    Herbert, Rob D; Gabriel, Michael

    2002-01-01

    Objective To determine the effects of stretching before and after exercising on muscle soreness after exercise, risk of injury, and athletic performance. Method Systematic review. Data sources Randomised or quasi-randomised studies identified by searching Medline, Embase, CINAHL, SPORTDiscus, and PEDro, and by recursive checking of bibliographies. Main outcome measures Muscle soreness, incidence of injury, athletic performance. Results Five studies, all of moderate quality, reported sufficient data on the effects of stretching on muscle soreness to be included in the analysis. Outcomes seemed homogeneous. Stretching produced small and statistically non-significant reductions in muscle soreness. The pooled estimate of reduction in muscle soreness 24 hours after exercising was only 0.9 mm on a 100 mm scale (95% confidence interval −2.6 mm to 4.4 mm). Data from two studies on army recruits in military training show that muscle stretching before exercising does not produce useful reductions in injury risk (pooled hazard ratio 0.95, 0.78 to 1.16). Conclusions Stretching before or after exercising does not confer protection from muscle soreness. Stretching before exercising does not seem to confer a practically useful reduction in the risk of injury, but the generality of this finding needs testing. Insufficient research has been done with which to determine the effects of stretching on sporting performance. What is already known on this topicReviews of the effects of stretching before exercising have drawn conflicting conclusionsThe literature on effects of stretching before and after exercising on muscle soreness and risk of injury has not been systematically reviewedWhat this study addsStretching before and after exercising does not confer protection from muscle soreness and stretching before exercise does not seem to confer a practically useful reduction in the risk of injury PMID:12202327

  13. Muscle soreness, swelling, stiffness and strength loss after intense eccentric exercise.

    Science.gov (United States)

    Cleak, M J; Eston, R G

    1992-01-01

    High-intensity eccentric contractions induce performance decrements and delayed onset muscle soreness. The purpose of this investigation was to study the magnitude and time course of such decrements and their interrelationships in 26 young women of mean(s.d.) age 21.4(3.3) years. Subjects performed 70 maximal eccentric contractions of the elbow flexors on a pulley system, specially designed for the study. The non-exercised arm acted as the control. Measures of soreness, tenderness, swelling (SW), relaxed elbow joint angle (RANG) and isometric strength (STR) were taken before exercise, immediately after exercise (AE), analysis of variance and at 24-h intervals for 11 days. There were significant (P < 0.01, analysis of variance) changes in all factors. Peak effects were observed between 24 and 96 h AE. With the exception of STR, which remained lower (P < 0.01), all variables returned to baseline levels by day 11. A non-significant correlation between pain and STR indicated that pain was not a major factor in strength loss. Also, although no pain was evident, RANG was decreased immediately AE. There was no relationship between SW, RANG and pain. The prolonged nature of these symptoms indicates that repair to damaged soft tissue is a slow process. Strength loss is considered particularly important as it continues when protective pain and tenderness have disappeared. This has implications for the therapeutic management of patients with myopathologies and those receiving eccentric exercise for rehabilitation. PMID:1490222

  14. Blood flow after contraction and cuff occlusion is reduced in subjects with muscle soreness after eccentric exercise.

    Science.gov (United States)

    Souza-Silva, E; Christensen, S W; Hirata, R P; Larsen, R G; Graven-Nielsen, T

    2017-04-28

    Delayed onset muscle soreness (DOMS) occurs within 1-2 days after eccentric exercise, but the mechanism mediating hypersensitivity is unclear. This study hypothesized that eccentric exercise reduces the blood flow response following muscle contractions and cuff occlusion, which may result in accumulated algesic substances being a part of the sensitization in DOMS. Twelve healthy subjects (five women) performed dorsiflexion exercise (five sets of 10 repeated eccentric contractions) in one leg, while the contralateral leg was the control. The maximal voluntary contraction (MVC) of the tibialis anterior muscle was recorded. Blood flow was assessed by ultrasound Doppler on the anterior tibialis artery (ATA) and within the anterior tibialis muscle tissue before and immediately after 1-second MVC, 5-seconds MVC, and 5-minutes thigh cuff occlusion. Pressure pain thresholds (PPTs) were recorded on the tibialis anterior muscle. All measures were done bilaterally at day 0 (pre-exercise), day 2, and day 6 (post-exercise). Subjects scored the muscle soreness on a Likert scale for 6 days. Eccentric exercise increased Likert scores at day 1 and day 2 compared with day 0 (Pexercise (day 0), reduced PPT (~25%, Peccentric contractions decreased vessel diameter, impaired the blood flow response, and promoted hyperalgesia. Thus, the results suggest that the blood flow reduction may be involved in the increased pain response after eccentric exercise. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Effects of neuromuscular electrical stimulation of the knee extensor muscles on muscle soreness and different serum parameters in young male athletes: preliminary data

    Science.gov (United States)

    Zorn, Carina; Szekeres, Thomas; Keilani, Mohammad; Fialka‐Moser, Veronika; Crevenna, Richard

    2007-01-01

    Aim To evaluate the effects of neuromuscular electrical stimulation (NMES) on muscle soreness and on a variety of serum parameters during and after NMES of knee extensor muscles of young, well trained subjects over a study period of 96 h. Methods Five male cyclists were included in this clinical observation. NMES (biphasic, asymmetric impulses) was applied through surface electrodes to both knee extensor muscles of each subject for 30 min. To determine changes in serum concentration of muscle proteins, blood samples were drawn at defined measure points before and after NMES. Muscle soreness was evaluated using a visual analogue scale at all measure points. Results There was a maximum (p<0.05) for “muscle pain” during stimulation but no significant changes could be detected after the stimulation period. Serum creatine kinase showed a peak with a significant increase (p<0.05) 24 h after NMES. Serum lactate levels only increased slightly (p = 0.08) during NMES. Conclusions Although the changes of blood parameters measured in the present work correspond to those reported in the literature on eccentric strength training, no delayed onset muscle pain could be detected. Further studies should be carried out, also investigating different stimulation protocols in non‐trained healthy subjects and in patients with less muscle mass. PMID:18037643

  16. Leucine-enriched essential amino acids attenuate muscle soreness and improve muscle protein synthesis after eccentric contractions in rats.

    Science.gov (United States)

    Kato, Hiroyuki; Suzuki, Hiromi; Mimura, Masako; Inoue, Yoshiko; Sugita, Mayu; Suzuki, Katsuya; Kobayashi, Hisamine

    2015-06-01

    Eccentric exercise results in prolonged muscle weakness and muscle soreness, which are typical symptoms of muscle damage. Recovery from muscle damage is related to mammalian target of rapamycin (mTOR) activity. Leucine-enriched essential amino acids (LEAAs) stimulate muscle protein synthesis via activation of the mTOR pathway. Therefore, we investigated the effect of LEAAs on muscle protein synthesis and muscle soreness after eccentric contractions (EC). Male Sprague-Dawley rats (9-11 weeks old) were administered an LEAA solution (AminoL40; containing 40 % leucine and 60 % other essential amino acids) at 1 g/kg body weight or distilled water (control) 30 min before and 10 min after EC. Tibialis anterior (TA) muscle was exposed to 500 EC by electrical stimulation under anesthesia. The fractional synthesis rate (FSR; %/h) in the TA muscle was measured by incorporating L-[ring-(2)H5] phenylalanine into skeletal muscle protein. Muscle soreness was evaluated by the paw withdrawal threshold using the Randal-Selitto test with some modifications from 1 to 3 days after EC. The FSR in the EC-control group (0.147 ± 0.016 %/h) was significantly lower than in the sedentary group (0.188 ± 0.016 %/h, p < 0.05). AminoL40 administration significantly mitigated the EC-induced impairment of the FSR (0.172 ± 0.018 %/h). EC decreased the paw withdrawal threshold at 1 and 2 days after EC, which indicated that EC induced muscle soreness. Furthermore, AminoL40 administration alleviated the decreased paw withdrawal threshold. These findings suggest that LEAA supplementation improves the rate of muscle protein synthesis and ameliorates muscle soreness after eccentric exercise.

  17. Effects of Varying Recovery Periods on Muscle Enzymes, Soreness, and Performance in Baseball Pitchers

    Science.gov (United States)

    Potteiger, Jeffrey A.; Blessing, Daniel L.; Wilson, G. Dennis

    1992-01-01

    In this study we examined the effects of varied recovery time on serum creatine kinase (CK), serum lactate dehydrogenase (LDH), muscle soreness, and pitch velocity in baseball pitchers. Ten males who had pitching experience participated in the study. After an 18-day training period, subjects pitched three simulated games. Game A and Game B were separated by four days of rest, while Game B and Game C were separated by two days of rest. CK, LDH, and muscle soreness were evaluated at the following times: before and immediately after exercise, and six, 24, 48, and 72 hours after exercise. Muscle performance was evaluated by measuring pitch velocity during the games. The CK level was elevated after each game (Game A - 249 U/l; Game B - 243 U/l; and Game C - 240 U/l); then it dropped toward baseline (p≤0.01). CK post-exercise values were not different among games A, B, and C. LDH displayed a response similar to CK; however, there was a reduction over the span of the games (p≤0.05). Muscle soreness was significantly elevated immediately after exercise (p≤0.01) compared to all other measurement times. Pitch velocity was not different among games A, B, and C. Results indicate that muscle damage, as evidenced by CK release, occurs in response to baseball pitching. However CK values, muscle soreness, and pitch velocity are not significantly affected by changes in the amount of recovery time typically scheduled between games. PMID:16558126

  18. Treatment of Ischial Pressure Sores with Both Profunda Femoris Artery Perforator Flaps and Muscle Flaps

    Science.gov (United States)

    Kim, Chae Min; Yun, In Sik; Lee, Dong Won; Lew, Dae Hyun; Rah, Dong Kyun

    2014-01-01

    Background Reconstruction of ischial pressure sore defects is challenging due to extensive bursas and high recurrence rates. In this study, we simultaneously applied a muscle flap that covered the exposed ischium and large bursa with sufficient muscular volume and a profunda femoris artery perforator fasciocutaneous flap for the management of ischial pressure sores. Methods We retrospectively analyzed data from 14 patients (16 ischial sores) whose ischial defects had been reconstructed using both a profunda femoris artery perforator flap and a muscle flap between January 2006 and February 2014. We compared patient characteristics, operative procedure, and clinical course. Results All flaps survived the entire follow-up period. Seven patients (50%) had a history of surgery at the site of the ischial pressure sore. The mean age of the patients included was 52.8 years (range, 18-85 years). The mean follow-up period was 27.9 months (range, 3-57 months). In two patients, a biceps femoris muscle flap was used, while a gracilis muscle flap was used in the remaining patients. In four cases (25%), wound dehiscence occurred, but healed without further complication after resuturing. Additionally, congestion occurred in one case (6%), but resolved with conservative treatment. Among 16 cases, there was only one (6%) recurrence at 34 months. Conclusions The combination of a profunda femoris artery perforator fasciocutaneous flap and muscle flap for the treatment of ischial pressure sores provided pliability, adequate bulkiness and few long-term complications. Therefore, this may be used as an alternative treatment method for ischial pressure sores. PMID:25075362

  19. Treatment of Ischial Pressure Sores with Both Profunda Femoris Artery Perforator Flaps and Muscle Flaps

    Directory of Open Access Journals (Sweden)

    Chae Min Kim

    2014-07-01

    Full Text Available Background Reconstruction of ischial pressure sore defects is challenging due to extensive bursas and high recurrence rates. In this study, we simultaneously applied a muscle flap that covered the exposed ischium and large bursa with sufficient muscular volume and a profunda femoris artery perforator fasciocutaneous flap for the management of ischial pressure sores. Methods We retrospectively analyzed data from 14 patients (16 ischial sores whose ischial defects had been reconstructed using both a profunda femoris artery perforator flap and a muscle flap between January 2006 and February 2014. We compared patient characteristics, operative procedure, and clinical course. Results All flaps survived the entire follow-up period. Seven patients (50% had a history of surgery at the site of the ischial pressure sore. The mean age of the patients included was 52.8 years (range, 18-85 years. The mean follow-up period was 27.9 months (range, 3-57 months. In two patients, a biceps femoris muscle flap was used, while a gracilis muscle flap was used in the remaining patients. In four cases (25%, wound dehiscence occurred, but healed without further complication after resuturing. Additionally, congestion occurred in one case (6%, but resolved with conservative treatment. Among 16 cases, there was only one (6% recurrence at 34 months. Conclusions The combination of a profunda femoris artery perforator fasciocutaneous flap and muscle flap for the treatment of ischial pressure sores provided pliability, adequate bulkiness and few long-term complications. Therefore, this may be used as an alternative treatment method for ischial pressure sores.

  20. COLD VRS HEAT AFTER EXERCISE- IS THERE A CLEAR WINNER FOR MUSCLE SORENESS.

    Science.gov (United States)

    Petrofsky, Jerrold; Khowailed, Iman Akef; Lee, Haneul; Berk, Lee; Bains, Gurinder; Akerkar, Siddhesh; Shah, Jinal; Al-Dabbak, Fuad; Laymon, Mike

    2015-08-14

    Due to the differences in the exercise type, temperature and timing of the use of cold and heat after exercise in different studies, there is no clear conclusion as to the efficacy of either modality on reducing delayed onset muscle soreness. One hundred subjects at similar fitness levels were examined. They accomplished leg squats for 15 minutes and heat and cold were applied after or 24 hours after exercise using ThermaCare heat or cold wraps. Measurements obtained were strength, the force to passively move the knee, analog visual pain scales, and blood myoglobin. Control subjects lost 24% strength after exercise. Subjects with heat or cold just after exercise only lost 4% strength (p<0.01). Cold applied after 24 hours was better than heat at 24 for strength recovery. Heat or cold applied after exercise was significantly better to prevent elastic tissue damage (p<0.01) while heat and cold immediate after exercise caused no loss in muscle myoglobin whereas heat or cold after 24 hours showed no less muscle damage from myoglobin than control subjects. Myoglobin in the control and heat and cold 24 groups averaged 135.1% of the baseline data but averaged 106.1% of baseline in the heat and cold immediate groups. For reducing pain, control subjects showed a significant amount of pain the days after exercise. But cold immediately after exercise or 24 hours later was superior to heat in reducing pain. In conclusion, both cold and heat appear to be efficacious in reducing muscle damage after exercise.

  1. Cold Vs. Heat After Exercise-Is There a Clear Winner for Muscle Soreness.

    Science.gov (United States)

    Petrofsky, Jerrold S; Khowailed, Iman Akef; Lee, Haneul; Berk, Lee; Bains, Gurinder S; Akerkar, Siddhesh; Shah, Jinal; Al-Dabbak, Fuad; Laymon, Mike S

    2015-11-01

    Because of the differences in the exercise type, temperature, and timing of the use of cold and heat after exercise in different studies, there is no clear conclusion as to the efficacy of either modality on reducing delayed onset muscle soreness. One hundred subjects at similar fitness levels were examined. They accomplished leg squats for 15 minutes and heat and cold were applied after or 24 hours after exercise using ThermaCare heat or cold wraps. Measurements obtained were strength, the force to passively move the knee, analog visual pain scales, and blood myoglobin. Control subjects lost 24% strength after exercise. Subjects with heat or cold just after exercise only lost 4% strength (p < 0.01). For strength recovery, cold applied after 24 hours was better than heat at 24 hours. Heat or cold applied after exercise was significantly better to prevent elastic tissue damage (p < 0.01), whereas heat and cold immediately after exercise caused no loss in muscle myoglobin and heat or cold after 24 hours showed no less muscle damage from myoglobin than in control subjects. Myoglobin in the control and heat and cold 24-hour groups averaged 135.1% of the baseline data but averaged 106.1% of baseline in the immediate heat and cold groups. For reducing pain, control subjects showed a significant amount of pain the days after exercise. But cold immediately after exercise or 24 hours later was superior to heat in reducing pain. In conclusion, both cold and heat appear to be efficacious in reducing muscle damage after exercise.

  2. Pain and soreness associated with a percutaneous electrical stimulation muscle cramping protocol.

    Science.gov (United States)

    Miller, Kevin C; Knight, Kenneth L

    2007-11-01

    Muscle cramps are difficult to study scientifically because of their spontaneity and unpredictability. Various laboratory techniques to induce muscle cramps have been explored but the best technique for inducing cramps is unclear. Electrical stimulation appears to be the most reliable, but there is a perception that it is extremely painful. Data to support this perception are lacking. We hypothesized that electrical stimulation is a tolerable method of inducing cramps with few side effects. We measured cramp frequency (HZ), pain during electrical stimulation, and soreness before, at 5 s, and 30, 60, and 90 min after cramp induction using a 100-mm visual analog scale. Group 1 received tibial nerve stimulation on 5 consecutive days; Group 2 received it on alternate days for five total treatments. Pain and soreness were mild. The highest ratings occurred on Day 1 and decreased thereafter. Intersession reliability was high. Our study showed that electrical stimulation causes little pain or soreness and is a reliable method for inducing cramps.

  3. Cold-water immersion (cryotherapy for preventing and treating muscle soreness after exercise

    Directory of Open Access Journals (Sweden)

    Chris Bleakley

    Full Text Available BACKGROUND: Many strategies are in use with the intention of preventing or minimizing delayed onset muscle soreness and fatigue after exercise. Cold-water immersion, in water temperatures of less than 15 °C, is currently one of the most popular interventional strategies used after exercise. OBJECTIVES: To determine the effects of cold-water immersion in the management of muscle soreness after exercise. SEARCH METHODS: In February 2010, we searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials (The Cochrane Library (2010, Issue 1, Medline, Embase, Cumulative Index to Nursing and Allied Health (CINAHL, British Nursing Index and archive (BNI, and the Physiotherapy Evidence Database (PEDro. We also searched the reference lists of articles, handsearched journals and conference proceedings and contacted experts. In November 2011, we updated the searches of Central (2011, Issue 4, Medline (up to November Week 3 2011, Embase (to 2011 Week 46 and CINAHL (to 28 November 2011 to check for more recent publications. SELECTION CRITERIA: Randomized and quasi-randomized trials comparing the effect of using cold-water immersion after exercise with: passive intervention (rest/no intervention, contrast immersion, warm-water immersion, active recovery, compression, or a different duration/dosage of cold-water immersion. Primary outcomes were pain (muscle soreness or tenderness (pain on palpation, and subjective recovery (return to previous activities without signs or symptoms. DATA COLLECTION AND ANALYSIS: Three authors independently evaluated study quality and extracted data. Some of the data were obtained following author correspondence or extracted from graphs in the trial reports. Where possible, data were pooled using the fixed-effect model. MAIN RESULTS: Seventeen small trials were included, involving a total of 366 participants. Study quality was low. The temperature, duration and

  4. The Theory of Ashi Acupuncture Treatment to Delayed Muscle Soreness%阿是穴针刺法治疗延迟性肌肉酸痛原理

    Institute of Scientific and Technical Information of China (English)

    马士龙

    2015-01-01

    This paper introduces the concept of delayed onset muscle soreness and its mechanism.It implies that Ashi acupuncture can strengthen the assembling of contractile proteins,enhance the recovery of contraction structure,and then treat delayed onset muscle soreness with stable and lasting effects.%介绍了延迟性肌肉酸痛的概念及其机制。认为针刺阿是穴可以加强收缩蛋白的组装、合成而促进收缩结构的恢复,从而治疗延迟性肌肉酸痛,其作用持久稳定。

  5. Evaluation of local muscle soreness treatment with anterior bite splint made of soft putty impression material

    Directory of Open Access Journals (Sweden)

    Harry Laksono

    2013-03-01

    Full Text Available Background: Local muscle soreness is the most common temporomandibular disorders complaint of patients seeking treatment in the dental clinics. The emergency treatment that can be done in the clinics to manage this disorder is by making anterior bite splint. Anterior bite splint is usually made of acrylic, but currently there is a soft putty impression material that can also be used for making anterior bite splint. The effectiveness of soft putty anterior bite splint in local muscle soreness treatment still has not clear. Purpose: To determine the effectiveness of the soft putty impression material as a material used for making anterior bite splint in the treatment of local muscle soreness. Case: Six patients was reported five female patients aged 20-40 years old and one male patient aged 37 years old with local muscle soreness. Four female patients with a “click” sound on TMJ. Case management: Make differential diagnosis with screening history (anamnesis, clinical examination consists of extra oral examination such as muscle and temporomandibular joint palpation, measure the mandibular movement, end-feel, load test, intra oral examination and radiographic evaluation. Record the results and make the diagnosis. Make a soft putty anterior bite splint, adjusted and inserted in the maxillary anterior teeth. Record the results based on signs and symptoms. Conclusion: It can be concluded that anterior bite splint made of soft putty impression material is effective for treatment the local muscle soreness.Latar belakang: Salah satu tipe temporomandibular disorders yang paling sering dijumpai di klinik dokter gigi adalah local muscle soreness. Perawatan yang dapat dengan segera dilakukan di klinik untuk mengelola gangguan tersebut adalah dengan pembuatan anterior bite splint. Biasanya anterior bite splint terbuat dari akrilik, namun saat ini telah ada bahan cetak soft putty yang memungkinkan untuk dipakai sebagai bahan pembuatan anterior bite splint

  6. Neutrophilia and an Anti-Inflammatory Drug as Markers of Inflammation in Delayed Muscle Soreness.

    Science.gov (United States)

    Smith, Lucille L.; And Others

    This study reexamined the concept that delayed muscle soreness (DMS) is a form of inflammatory pain. This was accomplished by having 32 male volunteers perform exercise known to induce DMS and then assess the total and differential white blood cell changes. In addition, an anti-inflammatory drug, idomethacin, was administered to determine whether…

  7. Exercise-Induced Skeletal Muscle Damage.

    Science.gov (United States)

    Evans, William J.

    1987-01-01

    Eccentric exercise, in which the muscles exert force by lengthening, is associated with delayed onset muscle soreness. How soreness occurs, how recovery proceeds, and what precautions athletes should take are described. (Author/MT)

  8. Influence of fatigue, stress, muscle soreness and sleep on perceived exertion during submaximal effort.

    Science.gov (United States)

    Haddad, Monoem; Chaouachi, Anis; Wong, Del P; Castagna, Carlo; Hambli, Mourad; Hue, Olivier; Chamari, Karim

    2013-07-02

    The aim of this study was to assess the effects of the Hooper's Index variations (i.e., self-ratings of fatigue, stress, delayed onset muscle soreness (DOMS), and sleep) on rating of perceived exertion during a 10 min submaximal exercise training session (RPE-10 min) and then check the stability and the internal consistency of RPE-10 min. Seventeen junior soccer players took part in this study. The individual Hooper's indices taken before each training session were correlated with RPE-10 min during a constant intensity and duration effort (10 min) using Pearson product moment correlation. Intraclass correlation (ICC) was used to assess the internal consistency of the RPE-10 min. All individual correlations between RPE-10 min and quality of sleep and quantity of fatigue, stress, and DOMS were non-significant (p>0.05). No significant correlations were resulted between RPE-10 min and Hooper's Index in all athletes. The ICC of RPE-10 min was 0.77 thus demonstrating internal consistency. The results of the present study demonstrated the objectivity and utility of RPE as a psychological tool for monitoring training during traditional soccer training. Therefore, the results of the present study suggest that fatigue, stress, DOMS and sleep are not major contributors of perceived exertion during traditional soccer training without excessive training loads. It seems that psychobiological factors other than fatigue, stress, DOMS and sleep may have mediated the 10 min exercise perceptual intensity.

  9. Effects of Alcohol Consumption on Muscle Soreness and Inflammation During Recovery From Strenuous Exercise

    Directory of Open Access Journals (Sweden)

    Chao Yen Chen

    2014-10-01

    Full Text Available Although parties or get-togethers with alcoholic beverages after sporting competitions are popular, studies on the effects of alcohol ingestion after strenuous exercise on muscle damage and inflammation in non-drinkers’ are few and ambiguous. Therefore, the aim of this study was to investigate the effects of alcohol ingestion during recovery from an acute bout of exercise on muscle soreness and inflammatory markers in regular exercisers who do not regularly consume alcohol. Male participants (n = 15 completed two bouts of exercise on a rowing ergometer for 2000 m in a randomized fashion. All participants ingested 5 mL of alcoholic (AL or placebo (PL beverage per kg of body weight within 10 min post-exercise. Blood samples for blood alcohol, creatine kinase (CK, C-reactive protein (CRP, and interleukin (IL-6 concentrations were collected pre-exercise (T0, and at 1 (T1, 3 (T2, and 24 h (T3 post-ingestion. Self-reported muscle soreness was assessed at the same time points. Lactate levels were measured before exercise and within 1 h post-exercise. Muscle soreness was significantly lower in the AL than the PL trials at T3 (p < 0.05. Although CK, IL-6 and CRP levels were significantly higher during recovery than before exercising, there was no significant difference between the AL and PL trials. In addition, no significant difference in lactate concentrations between the two trials was evident in the 1 h after exercise. For regular exercisers, the alcoholic beverage ingested did not increase CK, IL-6, or CRP compared to their placebo trial, despite attenuated muscle soreness. Comparisons between drinkers and non-drinkers of high fitness ingesting permissible alcohol doses should be performed in the future.   Keywords: alcohol, inflammation, strenuous exercise, muscle damage

  10. Effects of protein supplements on muscle damage, soreness and recovery of muscle function and physical performance: a systematic review.

    Science.gov (United States)

    Pasiakos, Stefan M; Lieberman, Harris R; McLellan, Tom M

    2014-05-01

    Protein supplements are frequently consumed by athletes and recreationally-active individuals, although the decision to purchase and consume protein supplements is often based on marketing claims rather than evidence-based research. To provide a systematic and comprehensive analysis of literature examining the hypothesis that protein supplements enhance recovery of muscle function and physical performance by attenuating muscle damage and soreness following a previous bout of exercise. English language articles were searched with PubMed and Google Scholar using protein and supplements together with performance, exercise, competition and muscle, alone or in combination as keywords. Inclusion criteria required studies to recruit healthy adults less than 50 years of age and to evaluate the effects of protein supplements alone or in combination with carbohydrate on performance metrics including time-to-exhaustion, time-trial or isometric or isokinetic muscle strength and markers of muscle damage and soreness. Twenty-seven articles were identified of which 18 dealt exclusively with ingestion of protein supplements to reduce muscle damage and soreness and improve recovery of muscle function following exercise, whereas the remaining 9 articles assessed muscle damage as well as performance metrics during single or repeat bouts of exercise. Papers were evaluated based on experimental design and examined for confounders that explain discrepancies between studies such as dietary control, training state of participants, sample size, direct or surrogate measures of muscle damage, and sensitivity of the performance metric. High quality and consistent data demonstrated there is no apparent relationship between recovery of muscle function and ratings of muscle soreness and surrogate markers of muscle damage when protein supplements are consumed prior to, during or after a bout of endurance or resistance exercise. There also appears to be insufficient experimental data

  11. Influence of ginger and cinnamon intake on inflammation and muscle soreness endued by exercise in Iranian female athletes

    Directory of Open Access Journals (Sweden)

    Nafiseh Shokri Mashhadi

    2013-01-01

    Conclusions: Administration of ginger and cinnamon in athlete women for six weeks did not show any significant change in the IL-6 level, but showed a decrease in muscle soreness in the cinnamon and ginger groups.

  12. Blood flow after contraction and cuff occlusion is reduced in subjects with muscle soreness after eccentric exercise

    DEFF Research Database (Denmark)

    Souza-Silva, Eduardo; Wittrup Christensen, Steffan; Hirata, Rogerio Pessoto

    2017-01-01

    anterior muscle. All measures were done bilaterally at day-0 (pre-exercise), day-2 and day-6 (post-exercise). Subjects scored the muscle soreness on a Likert scale for 6 days. Results: Eccentric exercise increased Likert scores at day-1 and day-2 compared with day-0 (P

  13. Post-exercise muscle soreness after eccentric exercise: psychophysical effects and implications on mean arterial pressure.

    Science.gov (United States)

    Bajaj, P; Graven-Nielsen, T; Arendt-Nielsen, L

    2001-10-01

    The aim of the study was to examine the time course of changes in pressure pain threshold (PPT), visual analogue scale (VAS) pain and tenderness scores, McGill Pain Questionnaire (MPQ) descriptors, pain areas, skin temperature and mean arterial pressure (MAP) following intensive eccentric exercise. In 11 healthy male subjects, eccentric exercise of the first dorsal interosseous muscle (FDI) of the right hand with 114% maximum voluntary contraction weight (MVC) was used to induce post-exercise muscle soreness (PEMS) in the right hand, while the left hand served as a control. At 24 h to 48 h all the pain profiles indicated the presence of PEMS in the right hand when compared to before exercise (Prole of central mechanisms in the PEMS, thereby giving further insight into clinical aspects of muscle pain.

  14. Fish oil supplementation reduces markers of oxidative stress but not muscle soreness after eccentric exercise.

    Science.gov (United States)

    Gray, Patrick; Chappell, Andrew; Jenkinson, Alison McE; Thies, Frank; Gray, Stuart R

    2014-04-01

    Due to the potential anti-inflammatory properties of fish-derived long chain n-3 fatty acids, it has been suggested that athletes should regularly consume fish oils-although evidence in support of this recommendation is not clear. While fish oils can positively modulate immune function, it remains possible that, due to their high number of double bonds, there may be concurrent increases in lipid peroxidation. The current study aims to investigate the effect of fish oil supplementation on exercise-induced markers of oxidative stress and muscle damage. Twenty males underwent a 6-week double-blind randomized placebo-controlled supplementation trial involving two groups (fish oil or placebo). After supplementation, participants undertook 200 repetitions of eccentric knee contractions. Blood samples were taken presupplementation, postsupplementation, immediately, 24, 48, and 72 hr postexercise and muscle soreness/maximal voluntary contraction (MVC) assessed. There were no differences in creatine kinase, protein carbonyls, endogenous DNA damage, muscle soreness or MVC between groups. Plasma thiobarbituric acid reactive substances (TBARS) were lower (p < .05) at 48 and 72 hr post exercise and H2O2 stimulated DNA damage was lower (p < .05) immediately postexercise in the fish oil, compared with the control group. The current study demonstrates that fish oil supplementation reduces selected markers of oxidative stress after a single bout of eccentric exercise.

  15. Season-long increases in perceived muscle soreness in professional rugby league players: role of player position, match characteristics and playing surface.

    Science.gov (United States)

    Fletcher, Ben D; Twist, Craig; Haigh, Julian D; Brewer, Clive; Morton, James P; Close, Graeme L

    2016-01-01

    Rugby League (RL) is a high-impact collision sport characterised by repeated sprints and numerous high-speed impacts and consequently players often report immediate and prolonged muscle soreness in the days after a match. We examined muscle soreness after matches during a full season to understand the extent to which match characteristics influence soreness. Thirty-one elite Super League players provided daily measures of muscle soreness after each of the 26 competitive fixtures of the 2012 season. Playing position, phase of the season, playing surface and match characteristics were recorded from each match. Muscle soreness peaked at day 1 and was still apparent at day 4 post-game with no attenuation in the magnitude of muscle soreness over the course of the season. Neither playing position, phase of season or playing surface had any effects on the extent of muscle soreness. Playing time and total number of collisions were significantly correlated with higher ratings of muscle soreness, especially in the forwards. These data indicate the absence "contact adaptations" in elite rugby players with soreness present throughout the entire season. Strategies must now be implemented to deal with the physical and psychological consequences of prolonged feeling of pain.

  16. Influence of Ginger and Cinnamon Intake on Inflammation and Muscle Soreness Endued by Exercise in Iranian Female Athletes

    Science.gov (United States)

    Mashhadi, Nafiseh Shokri; Ghiasvand, Reza; Askari, Gholamreza; Feizi, Awat; Hariri, Mitra; Darvishi, Leila; Barani, Azam; Taghiyar, Maryam; Shiranian, Afshin; Hajishafiee, Maryam

    2013-01-01

    Background: Ginger rhizomes (rich in gingerols, shogaols, paradols and zingerone) have been used in Asia for the treatment of asthma, diabetes, and pain, and have shown potent anti-inflammatory attributes. Common spices such as Cinnamon (including cinnamic aldehyde and cinnamyl aldehydeis) are used in food and many studies have focused on its anti-inflammatory components. Intense exercise can result in an inflammatory response to cell damage and also muscle soreness. The efficacy of dietary ginger and cinnamon as anti-inflammatory agents and their effectiveness in reducing muscle soreness has been investigated in limited studies on humans. Therefore, we have studied the effects of dietary ginger and cinnamon on inflammation and muscle soreness in Iranian female taekwondo players. Methods: Sixty healthy, trained women, aged 13-25 years, were enrolled in the six-week investigation and randomly categorized into three groups (cinnamon, ginger or placebo) and received 3 g of ginger, cinnamon or placebo powder each day, depending on the group they belonged to. The IL-6 level and Likert Scale of Muscle Soreness were evaluated at the beginning and the end of the study and compared among the groups. Results: Forty-nine of the participants completed the six-week intervention. There were no significant changes in the IL-6 cinnamon and ginger group when compared with the placebo group, whereas, there was a significant fall in muscle soreness in the cinnamon group and placebo (P < 0.1) and ginger group and placebo (P < 0.01). Conclusions: Administration of ginger and cinnamon in athlete women for six weeks did not show any significant change in the IL-6 level, but showed a decrease in muscle soreness in the cinnamon and ginger groups. PMID:23717759

  17. Efficacy of massage on muscle soreness, perceived recovery, physiological restoration and physical performance in male bodybuilders.

    Science.gov (United States)

    Kargarfard, Mehdi; Lam, Eddie T C; Shariat, Ardalan; Shaw, Ina; Shaw, Brandon S; Tamrin, Shamsul B M

    2016-01-01

    It is believed that sport massage after intensive exercise might improve power and perceptual recovery in athletes. However, few studies have been done in this area. This study aimed to examine the effect of massage on the performance of bodybuilders. Thirty experienced male bodybuilders were randomly assigned to either a massage group (n = 15) or a control group (n = 15). Both groups performed five repetition sets at 75-77% of 1RM of knee extensor and flexor muscle groups. The massage group then received a 30-min massage after the exercise protocol while the control group maintained their normal passive recovery. Criteria under investigation included: plasma creatine kinase (CK) level, agility test, vertical jump test, isometric torque test, and perception of soreness. All variables were measured over 6 time periods: baseline, immediately after the DOMS inducing protocol, right after the massage, and 24, 48, and 72 h after the massage. Both groups showed significant (P < .001) decreases in jumping, agility performance, and isometric torque, but significant (P < .001) increases in CK and muscle soreness levels. The massage group in general demonstrated a better recovery rate. As such, a post-exercise massage session can improve the exercise performance and recovery rate in male bodybuilders after intensive exercise.

  18. Timing influence of carbohydrate-protein ingestion on muscle soreness and next-day running performance.

    Science.gov (United States)

    Greer, Beau Kjerulf; Price, Anna; Jones, Brett

    2014-06-01

    The present study investigates timing effects of a carbohydrate-protein (CHO-PROT) beverage on indicators of muscle damage and next day running performance. Nine trained subjects completed three trials of a 30 min downhill run, followed by a 1.5 mile treadmill running time trial 24 hr later in a blinded, crossover design. Either a CHO-PROT or noncaloric placebo beverage was given 30 and 5 min prior to, at the 15 min mark during, immediately after, and 30 min after the downhill running protocol. In the first treatment (T1), a total of 360 kilocalories were given 30 and 5 min prior to downhill running, as well as at the 15 min mark, with placebos used at other time points. In the second treatment (T2), an isocaloric amount was given but only immediately after and 30 min after downhill running, with placebos used at other time points. In the placebo treatment, a placebo was given at all time points. There were no significant differences in the 1.5 mile time trial or soreness between trials (p > .05). Regardless of timing, the ingestion of a CHO-PROT beverage had no effect on next day running performance or muscular soreness versus a placebo.

  19. The Effect of Gender and Menstrual Phase on Serum Creatine Kinase Activity and Muscle Soreness Following Downhill Running.

    Science.gov (United States)

    Oosthuyse, Tanja; Bosch, Andrew N

    2017-02-23

    Serum creatine kinase (CK) activity reflects muscle membrane disruption. Oestrogen has antioxidant and membrane stabilising properties, yet no study has compared the CK and muscle soreness (DOMS) response to unaccustomed exercise between genders when all menstrual phases are represented in women. Fifteen eumenorrhoeic women (early follicular, EF (n = 5); late follicular, LF (n = 5); mid-luteal, ML (n = 5) phase) and six men performed 20 min of downhill running (-10% gradient) at 9 km/h. Serum CK activity and visual analogue scale rating of perceived muscle soreness were measured before, immediately, 24-h, 48-h and 72-h after exercise. The 24-h peak CK response (relative to pre-exercise) was similar between women and men (mean change (95% confidence interval): 58.5 (25.2 to 91.7) IU/L; 68.8 (31.3 to 106.3) IU/L, respectively). However, serum CK activity was restored to pre-exercise levels quicker in women (regardless of menstrual phase) than men; after 48-h post exercise in women (16.3 (-4.4 to 37.0) IU/L; 56.3 (37.0 to 75.6) IU/L, respectively) but only after 72-h in men (14.9 (-14.8 to 44.6) IU/L). Parallel to the CK response, muscle soreness recovered by 72-h in men. Conversely, the women still reported muscle soreness at 72-h despite CK levels being restored by 48-h; delayed recovery of muscle soreness appeared mainly in EF and LF. The CK and DOMS response to downhill running is gender-specific. The CK response recovers quicker in women than men. The CK and DOMS response occur in concert in men but not in women. The DOMS response in women is prolonged and may be influenced by menstrual phase.

  20. The Effect of Gender and Menstrual Phase on Serum Creatine Kinase Activity and Muscle Soreness Following Downhill Running

    Directory of Open Access Journals (Sweden)

    Tanja Oosthuyse

    2017-02-01

    Full Text Available Serum creatine kinase (CK activity reflects muscle membrane disruption. Oestrogen has antioxidant and membrane stabilising properties, yet no study has compared the CK and muscle soreness (DOMS response to unaccustomed exercise between genders when all menstrual phases are represented in women. Fifteen eumenorrhoeic women (early follicular, EF (n = 5; late follicular, LF (n = 5; mid-luteal, ML (n = 5 phase and six men performed 20 min of downhill running (−10% gradient at 9 km/h. Serum CK activity and visual analogue scale rating of perceived muscle soreness were measured before, immediately, 24-h, 48-h and 72-h after exercise. The 24-h peak CK response (relative to pre-exercise was similar between women and men (mean change (95% confidence interval: 58.5 (25.2 to 91.7 IU/L; 68.8 (31.3 to 106.3 IU/L, respectively. However, serum CK activity was restored to pre-exercise levels quicker in women (regardless of menstrual phase than men; after 48-h post exercise in women (16.3 (−4.4 to 37.0 IU/L; 56.3 (37.0 to 75.6 IU/L, respectively but only after 72-h in men (14.9 (−14.8 to 44.6 IU/L. Parallel to the CK response, muscle soreness recovered by 72-h in men. Conversely, the women still reported muscle soreness at 72-h despite CK levels being restored by 48-h; delayed recovery of muscle soreness appeared mainly in EF and LF. The CK and DOMS response to downhill running is gender-specific. The CK response recovers quicker in women than men. The CK and DOMS response occur in concert in men but not in women. The DOMS response in women is prolonged and may be influenced by menstrual phase.

  1. Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise

    Science.gov (United States)

    Crenshaw, A. G.; Friden, J.; Hargens, A. R.; Lang, G. H.; Thornell, L. E.

    1993-01-01

    A scintigraphic technique employing technetium pyrophosphate uptake was used to identify the area of skeletal muscle damage in the lower leg of four runners 24 h after an ultramarathon footrace (160 km). Most of the race had been run downhill which incorporated an extensive amount of eccentric work. Soreness was diffuse throughout the posterior region of the lower leg. In order to interpret what increased technetium uptake reflects and to express extreme endurance related damages, a biopsy was taken from the 3-D position of abnormal uptake. In addition, intramuscular pressures were determined in the deep posterior compartment. Scintigraphs revealed increased technetium pyrophosphate uptake in the medial portion of the gastrocnemius muscle. For 3698 fibres analysed, 33 fibres (1%) were necrotic, while a few other fibres were either atrophic or irregular shaped. A cluster of necrotic fibres occurred at the fascicular periphery for one subject and fibre type grouping occurred for another. Ultrastructural analysis revealed Z-line streaming near many capillaries and variously altered subsarcolemmal mitochondria including some with paracrystalline inclusions. The majority of the capillaries included thickened and irregular shaped endothelial cells. Intramuscular pressures of the deep posterior compartment were slightly elevated (12-15 mmHg) for three of the four subjects. Increased technetium uptake following extreme endurance running does not just reflect muscle necrosis but also subtle fibre abnormalities. Collectively, these pathological findings are attributed to relative ischaemia occurring during the race and during pre-race training, whereas, intramuscular pressure elevations associated with muscle soreness are attributed to mechanical stress caused by extensive eccentric work during the race.

  2. EFFECTS OF TWO DIFFERENT DOSAGE OF BCAA SUPPLEMENTATION ON SERUM INDICES OF MUSCLE DAMAGE AND SORENESS IN SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Payam Mohamad-Panahi

    2013-06-01

    Full Text Available The purpose of this study was to investigation of the effects of two different dose of BCAA supplementation on serum indices of muscle damage and soreness in soccer players. 30 male soccer players (age: 20.2±0.6 yr participated as subjects in this study. Subjects were randomly divided into three groups (double-blind design. All subjects performed lower- body resistance exercise (6 sets, 10 repetitions, 70% 1RM. The BCAA was given at doses of 200 and 450 mg.kg -1 BW for supplemental groups 1 and 2, respectively, 30 minutes before and after to exercise tests and carbohydrate was given at dose of 200 mg.kg -1 BW for placebo group. To identify enzymes activity (IU/L, venous blood samples were collected 30 min prior to exercise and at 24 and 48 hrs post exercise. Data were statistically analyzed using repeated measures ANOVA and Bonfferoni test. Baseline CK, CK-MB and muscle soreness were determined 30 minutes before the exercise test. Baseline serum values for CK, CK-MB and baseline muscle soreness were not different between groups in the 30 minutes before the exercise test (p>0/05. However, there were significant increases between the pre-exercise and post-exercise values for CK, CK-MB and muscle soreness from 24 hrs to 48 hrs post-test (p<0/05, but there were no significant differences between two groups (p< 0.05(. These results suggested that two different dosages of BCAA supplementation did not affect muscle damage and muscle sureness during resistance exercise bout in soccer players.

  3. THE EFFECTS OF OMEGA-3 INTAKE ON DELAYED ONSET MUSCLE SORNESS IN NON-ATHLET MEN

    Directory of Open Access Journals (Sweden)

    Ali Rajabi

    2013-01-01

    Full Text Available Delayed onset muscle soreness (DOMS is classified as a muscle strain that presents with tenderness and stiffness one to two days after exercise. At present there are multiple proposed methods for treating DOMS, including anti-inflammatory medication, stretching, homeopathy, L-carnitine, rest and light exercise. The purpose of this study was to investigation of the effects of omega-3 intake on delayed onset muscle soreness in non-athlete men. 20 healthy subjects (age: 20.5±1.8 years participated as subjects in this study. Subjects were randomly divided into two groups (experimental and control. In the experimental group, subjects consume daily 2000 mg of omega-3; 2 times per day for 1 month before and 48 hours after perform leg press exercise with eccentric pattern. Similarly, the с was taking in the control group. The results showed significant decrease in severity of DOMS (CK and LDH levels and decreased knee's range of motion in experimental group in comparison with control group (p<0.05. As a result of our study it is suggested that the use of omega-3 supplement can effectively reduce DOMS caused by eccentric exercise.

  4. The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise.

    Science.gov (United States)

    Legault, Zachary; Bagnall, Nicholas; Kimmerly, Derek S

    2015-10-01

    The study aimed to examine the effects that L-glutamine supplementation has on quadriceps muscle strength and soreness ratings following eccentric exercise. It was hypothesized that glutamine ingestion would quicken the recovery rate of peak force production and decrease muscle soreness ratings over a 72-hr recovery period. Sixteen healthy participants (8♀/8♂; 22 ± 4 years) volunteered in a double-blind, randomized, placebo-controlled crossover study. Supplement conditions consisted of isoenergetic placebo (maltodextrin, 0.6 g·kg-1·day-1) and L-glutamine (0.3 g·kg-1·day-1 + 0.3 g·kg-1·day-1 maltodextrin) ingestion once per day over 72 hr. Knee extensor peak torque at 0°, 30°, and 180° per second and muscle soreness were measured before, immediately following, 24, 48, and 72 hr posteccentric exercise. Eccentric exercise consisted of 8 sets (10 repetitions/set) of unilateral knee extension at 125% maximum concentric force with 2-min rest intervals. L-glutamine resulted in greater relative peak torque at 180°/sec both immediately after (71 ± 8% vs. 66 ± 9%), and 72 hr (91 ± 8% vs. 86 ± 7%) postexercise (all, p eccentric exercise. The effect of L-glutamine on muscle force recovery may be greater in men than women.

  5. Rest interval between resistance exercise sets: length affects volume but not creatine kinase activity or muscle soreness.

    Science.gov (United States)

    Evangelista, Renato; Pereira, Rafael; Hackney, Anthony C; Machado, Marco

    2011-03-01

    To compare differences between two different rest interval lengths between sets on the volume completed, muscle damage and muscle soreness during a resistance exercise bout. Twenty-eight healthy sedentary men (18 ± 1 y old) volunteered to participate in this study and were divided into the 1 min (1RI; n = 14) or 3 min (3RI; n = 14) rest interval length between sets. They were submitted to maximal voluntary isometric contraction strength (MVC) and then performed a resistance exercise protocol constituted for three sets of biceps curl at 40% of MVC with 1 min (1RI group) or 3 min (3RI group) interval length between sets. Each bout was performed to voluntary fatigue and the workout volume completed was calculated. Subjects provided blood samples before each bout, and at 24, and 48 h following exercise to evaluate serum CK activity. Muscle soreness was analyzed through visual analog scale, which was presented to subjects before first bout, immediately after exercise protocol and at 24, and 48 h following exercise. The results demonstrated that the subjects with longer rest intervals provide greater workout volume as expected, but there were no differences in serum CK activity and muscle soreness between groups. Training with high-volume, low-intensity resistance training, exercising with short rest intervals does not appear to present any additional challenge to recovery in untrained subjects.

  6. The Effects of Eccentric Contraction Duration on Muscle Strength, Power Production, Vertical Jump, and Soreness.

    Science.gov (United States)

    Mike, Jonathan N; Cole, Nathan; Herrera, Chris; VanDusseldorp, Trisha; Kravitz, Len; Kerksick, Chad M

    2017-03-01

    Mike, JN, Cole, N, Herrera, C, VanDusseldorp, T, Kravitz, L, and Kerksick, CM. The effects of eccentric contraction duration on muscle strength, power production, vertical jump, and soreness. J Strength Cond Res 31(3): 773-786, 2017-Previous research has investigated the effects of either eccentric-only training or comparing eccentric and concentric exercise on changes related to strength and power expression, but no research to date has investigated the impact of altering the duration of either the concentric or the eccentric component on these parameters. Therefore, the purpose of this study was to assess the duration of eccentric (i.e., 2-second, 4-second vs. 6-second) muscle contractions and their effect on muscle strength, power production, vertical jump, and soreness using a plate-loaded barbell Smith squat exercise. Thirty college-aged men (23 ± 3.5 years, 178 ± 6.8 cm, 82 ± 12 kg, and 11.6 ± 5.1% fat) with 3.0 ± 1.0 years of resistance training experience and training frequency of 4.3 ± 0.9 days per week were randomized and assigned to 1 of 3 eccentric training groups that incorporated different patterns of contraction. For every repetition, all 3 groups used 2-second concentric contractions and paused for 1 second between the concentric and eccentric phases. The control group (2S) used 2-second eccentric contractions, whereas the 4S group performed 4-second eccentric contractions and the 6S group performed 6-second eccentric contractions. All repetitions were completed using the barbell Smith squat exercise. All participants completed a 4-week training protocol that required them to complete 2 workouts per week using their prescribed contraction routine for 4 sets of 6 repetitions at an intensity of 80-85% one repetition maximum (1RM). For all performance data, significant group × time (G × T) interaction effects were found for average power production across all 3 sets of a squat jump protocol (p = 0.04) while vertical jump did not reach

  7. The impact of a pre-loaded multi-ingredient performance supplement on muscle soreness and performance following downhill running.

    Science.gov (United States)

    Ormsbee, Michael J; Ward, Emery G; Bach, Christopher W; Arciero, Paul J; McKune, Andrew J; Panton, Lynn B

    2015-01-01

    The effects of multi-ingredient performance supplements (MIPS) on perceived soreness, strength, flexibility and vertical jump performance following eccentric exercise are unknown. The purpose of this study was to determine the impact of MIPS (NO-Shotgun®) pre-loaded 4 weeks prior to a single bout of downhill running (DHR) on muscle soreness and performance. Trained male runners (n = 20) were stratified by VO2max, strength, and lean mass into two groups; MIPS (n = 10) ingested one serving daily of NO-Shotgun® for 28 days and 30 min prior to all post-testing visits, Control (CON; n = 10) consumed an isocaloric maltodextrin placebo in an identical manner as MIPS. Perceived soreness and performance measurements (strength, flexibility, and jump height) were tested on 6 occasions; 28 days prior to DHR, immediately before DHR (PRE), immediately post (POST) DHR, 24, 48, and 72 hr post-DHR. Perceived soreness significantly increased (p < 0.05) post DHR compared to PRE at all time-points, with no difference between groups. Creatine kinase (CK) and lactate dehydrogenase (LDH) increased over time (p < 0.001) with no group x time interactions (p = 0.236 and p = 0.535, respectively). Significant time effects were measured for strength (p = 0.001), flexibility (p = 0.025) and vertical jump (p < 0.001). There were no group x time interactions for any performance measurements. Consumption of MIPS for 4 weeks prior to a single bout of DHR did not affect perceived soreness, muscle damage, strength, flexibility, or jump performance compared to an isocaloric placebo in trained male runners following a single bout of DHR.

  8. The effect of kinesio taping versus stretching techniques on muscle soreness, and flexibility during recovery from nordic hamstring exercise.

    Science.gov (United States)

    Ozmen, Tarik; Yagmur Gunes, Gokce; Dogan, Hanife; Ucar, Ilyas; Willems, Mark

    2017-01-01

    The purpose of this study was to examine the effects of static stretching, proprioceptive neuromuscular facilitation (PNF) stretching, or kinesio taping (KT) on muscle soreness and flexibility during recovery from exercise. Sixty-five females were randomly assigned to four groups: PNF stretching (n = 15), static stretching (n = 16), KT (n = 17), and control (n = 17). All participants performed nordic hamstring exercise (5 sets of 8 repetitions). In all groups, hamstring flexibility at 24 h and 48 h was not changed from baseline (p > .05). The muscle soreness was measured higher at 48 h post-exercise compared with baseline in the control group (p = .04) and at 24 h post-exercise compared with baseline in the PNF group (p  .05). The KT application and pre-exercise stretching have no contribute to flexibility at 24 h and 48 h after exercise, but may attenuate muscle soreness. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. The influence of an artificial playing surface on injury risk and perceptions of muscle soreness in elite Rugby Union.

    Science.gov (United States)

    Williams, S; Trewartha, G; Kemp, S P T; Michell, R; Stokes, K A

    2016-01-01

    This prospective cohort study investigated the influence of an artificial playing surface on injury risk and perceptions of muscle soreness in elite English Premiership Rugby Union players. Time loss (from 39.5 matches) and abrasion (from 27 matches) injury risk was compared between matches played on artificial turf and natural grass. Muscle soreness was reported over the 4 days following one match played on each surface by 95 visiting players (i.e., normally play on natural grass surfaces). There was a likely trivial difference in the overall injury burden relating to time-loss injuries between playing surfaces [rate ratio = 1.01, 90% confidence interval (CI): 0.73-1.38]. Abrasions were substantially more common on artificial turf (rate ratio = 7.92, 90% CI: 4.39-14.28), although the majority of these were minor and only two resulted in any reported time loss. Muscle soreness was consistently higher over the 4 days following a match on artificial turf in comparison with natural grass, although the magnitude of this effect was small (effect sizes ranging from 0.26 to 0.40). These results suggest that overall injury risk is similar for the two playing surfaces, but further surveillance is required before inferences regarding specific injury diagnoses and smaller differences in overall injury risk can be made.

  10. Postneedling soreness after deep dry needling of a latent myofascial trigger point in the upper trapezius muscle: Characteristics, sex differences and associated factors.

    Science.gov (United States)

    Martín-Pintado-Zugasti, Aitor; Rodríguez-Fernández, Ángel Luis; Fernandez-Carnero, Josue

    2016-04-27

    Postneedling soreness is considered the most frequent secondary effect associated to dry needling. A detailed description of postneedling soreness characteristics has not been previously reported. (1) to assess the intensity and duration of postneedling soreness and tenderness after deep dry needling of a trapezius latent myofascial trigger point (MTrP), (2) to evaluate the possible differences in postneedling soreness between sexes and (3) to analyze the influence on postneedling soreness of factors involved in the dry needling process. Sixty healthy subjects (30 men, 30 women) with latent MTrPs in the upper trapezius muscle received a dry needling intervention in the MTrP. Pain and pressure pain threshold (PPT) were assessed during a 72 hours follow-up period. Repeated measures analysis of covariance showed a significant effect for time in pain and in PPT. An interaction between sex and time in pain was obtained: women exhibited higher intensity in postneedling pain than men. The pain during needling and the number of needle insertions significantly correlated with postneedling soreness. Soreness and hyperalgesia are present in all subjects after dry needling of a latent MTrP in the upper trapezius muscle. Women exhibited higher intensity of postneedling soreness than men.

  11. The impact of a repeated bout of eccentric exercise on muscular strength, muscle soreness and creatine kinase.

    Science.gov (United States)

    Smith, L L; Fulmer, M G; Holbert, D; McCammon, M R; Houmard, J A; Frazer, D D; Nsien, E; Israel, R G

    1994-01-01

    The purpose of this study was to determine if there were any beneficial or detrimental effects regarding delayed onset muscle soreness (DOMS), serum creatine kinase (CK), and maximum concentric strength at 80% of 1-RMconc, if a bout of eccentric exercise was repeated at 48 h after an initial bout. A secondary purpose was to determine whether unaccustomed eccentrics might affect plasma cholesterol (TC). Twenty-six men were randomly assigned to a control (Group 1) or experimental group (Group 2). Both groups performed three sets (12 repetitions per set) of the eccentric phase of a chest press, at 80% of one repetition maximum (1-RMconc); Group 2 repeated this exercise 48 h later. DOMS and CK were measured before, and every 24 h for 8 days after; TC was measured before, and every 24 h for 4 days. Maximum strength during the concentric phase of a chest press (1-RMconc) was measured before and at 48-h intervals after. A repeated measures analysis of variance revealed a significant time effect (P < 0.05) for DOMS, CK and strength, but no significant difference between groups (P < 0.05). An interesting finding was the significant (P < 0.05) reduction in TC at 24, 48 and 72 h, after exercise in both groups, which we hypothesized was associated with cellular repair. From these results we concluded that when a bout of eccentrics is repeated 48 h after an initial bout, there is no change in the characteristic time-course and/or intensity of DOMS, CK or 1-RMconc. PMID:7894959

  12. Cold Sores

    Science.gov (United States)

    ... Previous Next Related Articles: Canker and Cold Sores Aloe Vera May Help Relieve Mouth Sores Canker Sore or Cold Sore? Mouth Sores: Caused By Student Stress? games Home | InfoBites | Find a Dentist | Your Family's Oral Health | Newsroom | RSS About AGD | Contact AGD | Site Map | ...

  13. A comparison of muscle damage, soreness and performance following a simulated contact and non-contact team sport activity circuit.

    Science.gov (United States)

    Singh, Tarveen K R; Guelfi, Kym J; Landers, Grant; Dawson, Brian; Bishop, David

    2011-09-01

    The aim was to compare the effect of a simulated team sport activity circuit (reflective of the activity demands of Australian football) either with or without body 'contact' on muscle soreness, damage, and performance when the circuit was repeated 48 h later. Eleven male, team-sport athletes completed a 'non-contact' (NCON) and a 'contact' (CON) version of the team sport activity circuit in a crossover design with at least 1 week between trials. The effect of CON and NCON on repeated 15m sprint and vertical jump performance was assessed by completing the same version of the circuit 48 h after the initial trial. The effect on perceived soreness and blood markers of muscle damage and inflammation was also determined. Subsequent performance was affected to a greater extent by CON, with both best and mean sprint times significantly slower 48h following CON (pprotein increased following CON but not NCON. In conclusion, Greater perceived soreness and decrements in performance of the simulated team sport activity circuit when repeated 48 h later were observed following CON.

  14. Effects of winter military training on energy balance, whole-body protein balance, muscle damage, soreness, and physical performance.

    Science.gov (United States)

    Margolis, Lee M; Murphy, Nancy E; Martini, Svein; Spitz, Marissa G; Thrane, Ingjerd; McGraw, Susan M; Blatny, Janet-Martha; Castellani, John W; Rood, Jennifer C; Young, Andrew J; Montain, Scott J; Gundersen, Yngvar; Pasiakos, Stefan M

    2014-12-01

    Physiological consequences of winter military operations are not well described. This study examined Norwegian soldiers (n = 21 males) participating in a physically demanding winter training program to evaluate whether short-term military training alters energy and whole-body protein balance, muscle damage, soreness, and performance. Energy expenditure (D2(18)O) and intake were measured daily, and postabsorptive whole-body protein turnover ([(15)N]-glycine), muscle damage, soreness, and performance (vertical jump) were assessed at baseline, following a 4-day, military task training phase (MTT) and after a 3-day, 54-km ski march (SKI). Energy intake (kcal·day(-1)) increased (P < 0.01) from (mean ± SD (95% confidence interval)) 3098 ± 236 (2985, 3212) during MTT to 3461 ± 586 (3178, 3743) during SKI, while protein (g·kg(-1)·day(-1)) intake remained constant (MTT, 1.59 ± 0.33 (1.51, 1.66); and SKI, 1.71 ± 0.55 (1.58, 1.85)). Energy expenditure increased (P < 0.05) during SKI (6851 ± 562 (6580, 7122)) compared with MTT (5480 ± 389 (5293, 5668)) and exceeded energy intake. Protein flux, synthesis, and breakdown were all increased (P < 0.05) 24%, 18%, and 27%, respectively, during SKI compared with baseline and MTT. Whole-body protein balance was lower (P < 0.05) during SKI (-1.41 ± 1.11 (-1.98, -0.84) g·kg(-1)·10 h) than MTT and baseline. Muscle damage and soreness increased and performance decreased progressively (P < 0.05). The physiological consequences observed during short-term winter military training provide the basis for future studies to evaluate nutritional strategies that attenuate protein loss and sustain performance during severe energy deficits.

  15. A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise

    DEFF Research Database (Denmark)

    Paulsen, G; Egner, I M; Drange, M

    2010-01-01

    The aim of this study was to investigate the effect of a cyclooxygenase (COX)-2 inhibitor on the recovery of muscle function, inflammation, regeneration after, and adaptation to, unaccustomed eccentric exercise. Thirty-three young males and females participated in a double-blind, placebo...... by celecoxib. In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect. However, it alleviated muscle soreness.......-controlled experiment. Seventy unilateral, voluntary, maximal eccentric actions with the elbow flexors were performed twice (bouts 1 and 2) with the same arm, separated by 3 weeks. The test group participants were administered 400 mg/day of celecoxib for 9 days after bout 1. After both bouts 1 and 2, concentric...

  16. Whole-body cryotherapy (extreme cold air exposure) for preventing and treating muscle soreness after exercise in adults.

    Science.gov (United States)

    Costello, Joseph T; Baker, Philip R A; Minett, Geoffrey M; Bieuzen, Francois; Stewart, Ian B; Bleakley, Chris

    2015-09-18

    Recovery strategies are often used with the intention of preventing or minimising muscle soreness after exercise. Whole-body cryotherapy, which involves a single or repeated exposure(s) to extremely cold dry air (below -100 °C) in a specialised chamber or cabin for two to four minutes per exposure, is currently being advocated as an effective intervention to reduce muscle soreness after exercise. To assess the effects (benefits and harms) of whole-body cryotherapy (extreme cold air exposure) for preventing and treating muscle soreness after exercise in adults. We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, the British Nursing Index and the Physiotherapy Evidence Database. We also searched the reference lists of articles, trial registers and conference proceedings, handsearched journals and contacted experts.The searches were run in August 2015. We aimed to include randomised and quasi-randomised trials that compared the use of whole-body cryotherapy (WBC) versus a passive or control intervention (rest, no treatment or placebo treatment) or active interventions including cold or contrast water immersion, active recovery and infrared therapy for preventing or treating muscle soreness after exercise in adults. We also aimed to include randomised trials that compared different durations or dosages of WBC. Our prespecified primary outcomes were muscle soreness, subjective recovery (e.g. tiredness, well-being) and adverse effects. Two review authors independently screened search results, selected studies, assessed risk of bias and extracted and cross-checked data. Where appropriate, we pooled results of comparable trials. The random-effects model was used for pooling where there was substantial heterogeneity. We assessed the quality of the evidence using GRADE. Four laboratory-based randomised controlled trials were included. These reported results for 64

  17. Pressure Sores

    Science.gov (United States)

    Pressure sores are areas of damaged skin caused by staying in one position for too long. They ... wheelchair, or are unable to change your position. Pressure sores can cause serious infections, some of which ...

  18. Pomegranate Supplementation Accelerates Recovery of Muscle Damage and Soreness and Inflammatory Markers after a Weightlifting Training Session

    Science.gov (United States)

    Ammar, Achraf; Turki, Mouna; Chtourou, Hamdi; Hammouda, Omar; Trabelsi, Khaled; Kallel, Choumous; Abdelkarim, Osama; Hoekelmann, Anita; Bouaziz, Mohamed; Ayadi, Fatma; Driss, Tarak; Souissi, Nizar

    2016-01-01

    Purpose The aim of this study was to investigate the effect of natural Pomegranate juice supplementation on performance and acute and delayed responses of muscle soreness and biomarkers of muscle damage after a weightlifting training session. Methods Nine elite weightlifters (21±0.5 years) performed two Olympic-Weightlifting-sessions after either placebo (PLA) or natural pomegranate juice (POMj) supplementations. Heart rate, blood pressure and blood samples (hematological parameters, muscle damage and C-reactive protein (CRP)) were collected at rest, 3min and 48h after each session. Weightlifting performance, RPE, and DOMS were also assessed after each training session. Results T-test showed higher performance (+8.30%) and lower RPE values (-4.37%) using POMj supplementation (p0.05). Additionally, during the 48h following the training session, POMj improved the recovery kinetic of SBP (p<0.01, 7.97%), CK (p<0.001, 11.34%), LDH (p<0.05, 7.30%) and ASAT (p<0.05, 6.77%). Indeed, the present study showed that 48h of recovery associated to natural POMj supplementation was sufficient to reach the resting values of the selected muscle damage markers after intensive training session. Conclusion Natural POMj seems to ameliorate the capacity to adhere to an intensive training program. Therefore, elite weightlifters are advised to use natural POMj during intensive training program and competition to accelerate muscle recovery. Trial Registration ClinicalTrials.gov NCT02697903 PMID:27764091

  19. Management of recurrent ischial pressure sore with gracilis muscle flap and V-Y profunda femoris artery perforator-based flap.

    Science.gov (United States)

    Lee, Su-Shin; Huang, Shu-Hung; Chen, Meng-Chum; Chang, Kao-Ping; Lai, Chung-Sheng; Lin, Sin-Daw

    2009-10-01

    Inappropriate seating has been implicated as a major contributing factor in ischial pressure-sore recurrence. During their lifetime, paraplegic patients may require several flaps for closure of the same or some other adjacent pressure sore. Despite a wide variety of flap reconstruction options being described, the ischium remains the most difficult pressure-sore site to treat. From June 1998 to July 2006, there were 253 pressure-sore patients operated upon at Kaohsiung Medical University Hospital. Ten patients (eight men and two women) suffered from recurrent ischial pressure sores, and all of them received more than one flap reconstruction for the ischial defect. For the treatment of the recurrent ischial pressure sore, gracilis muscle flap and readvancement of the V-Y profunda femoris artery perforator-based flap were used to fill the dead space as well as cover the defect. Among these 10 recurrent ischial pressure-sore patients, six of them had suffered bilateral ischial ulcers. Eight of them had previous sacral pressure sores. In all, 32 flap reconstruction procedures were performed on these 10 patients. Unfortunately, one patient had recurrent grade II bilateral ischial pressure sores after 11 months of ulcer-free period. The other nine patients had no recurrence noted, and enjoyed their lives with an average 27.2 months ulcer-free period (range 9-53 months). The fasciocutaneous flap provides a higher mechanical resistance than the detached and transposed muscle. However, for the recurrent ischial ulcer patients, readvancement of the perforator-based fasciocutaneous flap alone cannot provide adequate bulk to obliterate the 'dead space' after debridement of the bursa and the surrounding necrotic tissue. By combining the readvancement of V-Y profunda femoris artery perforator-based fasciocutaneous flap and gracilis muscle flap, these recurrent ischial ulcers will heal without complication. Recurrence of ulceration often develops despite successful flap closure

  20. Pressure-time cell death threshold for albino rat skeletal muscles as related to pressure sore biomechanics.

    Science.gov (United States)

    Linder-Ganz, Eran; Engelberg, Santiego; Scheinowitz, Mickey; Gefen, Amit

    2006-01-01

    Deep pressure sores (DPS) are associated with inadequate soft tissue perfusion and excessive tissue deformation over critical time durations, as well as with ischemia-reperfusion cycles and deficiency of the lymphatic system. Muscle tissue shows the lowest tolerance to pressure injuries, compared with more superficial tissues. In this communication, we present new histopathology data for muscle tissue of albino (Sprague-Dawley) rats exposed to pressures for 15 or 30 min. These data are superimposed with an extensive literature review of all previous histopathology reported for albino rat skeletal muscles subjected to pressure. The pooled data enabled a new mathematical characterization of the pressure-time threshold for cell death in striated muscle of rats, in the form of a sigmoid pressure-time relation, which extends the previous pressure-time relation to the shorter exposure periods. We found that for pressure exposures shorter than 1 h, the magnitude of pressure is the important factor for causing cell death and the exposure time has little or no effect: even relatively short exposures (15 min - 1 h) to pressures greater than 32 kPa (240 mmHg) cause cell death in rat muscle tissue. For exposures of 2 h or over, again the magnitude of pressure is the important factor for causing cell death: pressures greater than 9 kPa (67 mmHg) applied for over 2 h consistently cause muscle cell death. For the intermediate exposures (between 1 and 2 h), the magnitude of cell-death-causing pressure strongly depends on the time of exposure, i.e., critical pressure levels drop from 32 to 9 kPa. The present sigmoidal pressure-time cell death threshold is useful for design of studies in albino rat models of DPS, and may also be helpful in numerical simulations of DPS development, where there is often a need to extrapolate from tissue pressures to biological damage.

  1. 浅谈延迟性肌肉酸痛的原因及预防%The Cause and Prevention of Delayed-type Muscle Soreness

    Institute of Scientific and Technical Information of China (English)

    于华荣

    2012-01-01

    超过习惯强度的运动练习会产生延迟性肌肉酸痛,其致痛原因有损伤假说、痉挛假说和自由基假说。根据以上假说,采取相应的预防和减轻肌肉酸痛的措施,对于学校体育教育来说,具有现实的意义。%The exercise of more than habit strength may produce delayed-type muscle soreness, the cause of its induced pain include damage hypothesis, spasm hypothesis and the free radical hypothesis. According to the above hypothesis, the corresponding preventive measures are taken and can reduce muscle soreness. For school physical education, it has very practical significance.

  2. Compression garments to prevent delayed onset muscle soreness in soccer players

    Science.gov (United States)

    Valle, Xavier; Til, Lluís; Drobnic, Franchek; Turmo, Antonio; Montoro, José Bruno; Valero, Oliver; Artells, Rosa

    2013-01-01

    Summary The purpose of this study was to evaluate the use of a compression garment as DOMS prevention. This was accomplished by provoking a DOMS in 15 athletes, running on a treadmill at 73% of their maximal aerobic velocity, during 40 minutes with a 10% negative slope; wearing the compression garments on one thigh, protected thigh (PT), and not in the contralateral thigh, control thigh (CT). A clinical and MRI diagnosis of DOMS was performed. Biopsies in both vastus lateralis were done, and the amount and severity of the DOMS was estimated by measuring intracellular albumin, and lymphocytes CD3+ and neutrophils intra/interfibrilar infiltrates, 48h after the induced damaging exercise. There was less total injury in the PT than in the CT, a 26.7% average. These data indicate that this compression garment is an effective method to reduce the histological injury in DOMS. PMID:24596693

  3. Compression garments to prevent delayed onset muscle soreness in soccer players.

    Science.gov (United States)

    Valle, Xavier; Til, Lluís; Drobnic, Franchek; Turmo, Antonio; Montoro, José Bruno; Valero, Oliver; Artells, Rosa

    2013-10-01

    The purpose of this study was to evaluate the use of a compression garment as DOMS prevention. This was accomplished by provoking a DOMS in 15 athletes, running on a treadmill at 73% of their maximal aerobic velocity, during 40 minutes with a 10% negative slope; wearing the compression garments on one thigh, protected thigh (PT), and not in the contralateral thigh, control thigh (CT). A clinical and MRI diagnosis of DOMS was performed. Biopsies in both vastus lateralis were done, and the amount and severity of the DOMS was estimated by measuring intracellular albumin, and lymphocytes CD3+ and neutrophils intra/interfibrilar infiltrates, 48h after the induced damaging exercise. There was less total injury in the PT than in the CT, a 26.7% average. These data indicate that this compression garment is an effective method to reduce the histological injury in DOMS.

  4. Muscle stiffness, strength loss, swelling and soreness following exercise-induced injury in humans.

    Science.gov (United States)

    Howell, J N; Chleboun, G; Conatser, R

    1993-01-01

    1. In order to study injury-related changes in muscle stiffness, injury to the elbow flexors of thirteen human subjects was induced by a regimen of eccentric exercise. 2. Passive stiffness over an intermediate range of elbow angles was measured with a device which held the relaxed arm of the subject in the horizontal plane and stepped it through the range of elbow angles from 90 deg to near full extension at 180 deg. The relation between static torque and elbow angle was quite linear over the first 50 deg and was taken as stiffness. 3. Stiffness over this range of angles more than doubled immediately after exercise and remained elevated for about 4 days, and may result from low level myofibrillar activation induced by muscle stretch. 4. Arm swelling was biphasic; arm circumference increased by about 3% immediately after exercise, fell back toward normal, then increased by as much as 9% and remained elevated for as long as 9 days. 5. Ultrasound imaging showed most of the swelling immediately following the exercise to be localized to the flexor muscle compartment; subsequent swelling involved other tissue compartments as well. 6. Muscle strength declined by almost 40% after the exercise and recovery was only slight 10 days later; the half-time of recovery appeared to be as long as 5-6 weeks. PMID:8229798

  5. Sore Throats

    Science.gov (United States)

    ... relievers may help, if appropriate, your doctor may write you a prescription for an antibiotic. What are the causes and symptoms of a sore throat? Infections by contagious viruses or bacteria are the source of the majority ...

  6. Mouth Sores

    Science.gov (United States)

    ... contains fluoride. Note that whitening toothpastes may contain hydrogen peroxide, which can irritate sore mouths. Remove and ... Life Events College Relay For Life Donate a Car Ways to Give Memorial Giving Planned Giving Leadership ...

  7. Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study.

    Science.gov (United States)

    Bajaj, Prem; Arendt-Nielsen, Lars; Madeleine, Pascal; Svensson, Peter

    2003-01-01

    The role of tolperisone hydrochloride, a centrally acting muscle relaxant in relieving painful muscle spasm is recently being discussed. The present study hypothesizes that the prophylactic use of tolperisone hydrochloride may effectively relieve post-exercise muscle soreness, based on the spasm theory of exercise pain. Twenty male volunteers, aged 25.2 +/- 0.82 years (mean +/- SEM) participated in 10 sessions in which they received oral treatment with placebo or the centrally acting muscle relaxant tolperisone hydrochloride (150 mg) three times daily for 8 days, in randomized crossover double-blind design. Time course assessments were made for pressure pain threshold, Likert's pain score (0-5), pain areas, range of abduction, isometric force, and electromyography (EMG) root mean square (RMS) during maximum voluntary isometric force on day 1 and 6, immediately after an eccentric exercise of first dorsal interosseous muscle, and 24 and 48 h after the exercise. Treatment with placebo or tolperisone hydrochloride was initiated immediately after the assessments on the first day baseline assessments. On the sixth day baseline investigations were repeated and then the subjects performed six bouts of standardized intense eccentric exercise of first dorsal interosseous muscle for provocation of post-exercise muscle soreness (PEMS). Perceived intensity of warmth, tiredness, soreness and pain during the exercise bouts were recorded on a 10 cm visual analogue pain scale. VAS scores and pressure pain thresholds did not differ between tolperisone and placebo treatment. All VAS scores increased during the exercise bouts 2, 3, 4, 5 and 6 as compared to bout 1. Increased pain scores and pain areas were reported immediately after, 24 and 48 h after exercise. Pressure pain thresholds were reduced at 24 and 48 h after the exercise in the exercised hand. Range of abduction of the index finger was reduced immediately after the exercise and was still reduced at 24 h as compared to the

  8. 骨骼肌细胞损伤致延迟性肌肉酸痛:如何有效提高损伤肌肉恢复的速度和质量%Damage to skeletal muscle cells leads to delayed muscle soreness:how to effectively improve muscle recovery both in recovery speed and quality

    Institute of Scientific and Technical Information of China (English)

    刘强; 赵相轩; 潘诗农; 郭启勇

    2014-01-01

    BACKGROUND:There is no simple and effective method to relieve delayed muscle soreness. OBJECTIVE:To conclude the injured mechanism and therapies of delayed muscle soreness by reviewing literature about damage and repair of the skeletal muscle. METHODWanfang and PubMed databases (from January 1991 to January 2014) were retrieved for articles related to morphological structure of the skeletal muscle, mechanism of delayed muscle soreness, and treatment and repair of the skeletal muscle using the keywords of“molecular mechanisms;delayed onset muscle soreness;pain;skeletal muscle;injury”in Chinese and English, respectively. Final y, 24 articles were included in result analysis. RESULTS AND CONCLUSION:Studies have shown that skeletal muscle injury is related to calcium imbalance, energy imbalance and high concentration of active oxygen. Skeletal muscle injury includes metabolic injury, mechanical injury and inflammatory injury. Insulin-like growth factor, peroxisome proliferator-activated receptorγ-coactivator-1αpromoter and tumor necrosis factorαplay important roles in skeletal muscle repair process. Animal experiments have demonstrated that edaravone may reduce secondary damage and inflammatory infiltration by means of directly preventing rapid peroxidation injury of free radicals in the skeletal muscle. Clinical studies have shown that Chinese medicine preparations, massage and acupuncture can delay the occurrence of exercise-induced muscle injury and fatigue, to improve the speed and quality of the recovery of damaged muscles. The treatment of delayed muscle soreness can achieve satisfactory results by combining physiotherapy with traditional Chinese medicine.%背景:目前临床尚缺乏一种简单有效的防治延迟性肌肉酸痛的方法。  目的:查阅国内外有关骨骼肌损伤及修复的相关文献,归纳总结延迟性肌肉酸痛的损伤机制和治疗方法。  方法:检索1991年1月至2014年1月万方医学网和Pub

  9. Onset sequencing of selected lip muscles in stutterers and nonstutterers.

    Science.gov (United States)

    Guitar, B; Guitar, C; Neilson, P; O'Dwyer, N; Andrews, G

    1988-03-01

    The present study examined lip muscle activity during the speech production of stutterers and fluent speakers to provide information about the nature of stuttering blocks. Depressor Anguli Oris (DAO) and Depressor Labii Inferioris (DLI) were recorded, using hooked-wire electromyography (EMG), in 3 stutterers and 3 nonstutterers during productions of the words "peek", "puck", and "pack." EMG records indicated that nonstutterers activated DAO prior to DLI for production of the initial/p/. Stutterers frequently reversed this sequence of onset, particularly when they stuttered. Results are discussed in terms of mistiming versus anticipatory hypertension hypotheses about stuttering.

  10. Mouth Sores

    Science.gov (United States)

    ... or difficulty in swallowing, speaking, or chewing; any wart-like mass; hoarseness that lasts for more than two weeks; or any numbness in the oral/facial region. Tips to prevent mouth sores •Stop smoking. •Reduce stress. •Avoid injury to the mouth caused by hard ...

  11. Sporadic late-onset nemaline myopathy as a rare cause of slowly progressive muscle weakness with young adult onset.

    Science.gov (United States)

    Maeda, Meiko Hashimoto; Ohta, Hikari; Izutsu, Koji; Shimizu, Jun; Uesaka, Yoshikazu

    2015-05-01

    Sporadic late-onset nemaline myopathy (SLONM) is a rare intractable acquired myopathy characterized by progressive muscle weakness and atrophy, usually with middle to late adult onset. Autologous peripheral blood stem cell transplantation (auto-PBSCT) has been reported to be a promising treatment for SLONM. In this study we performed clinical characterization, muscle histopathological analysis, and muscle power monitoring after auto-PBSCT in a 27-year-old HIV-negative man with monoclonal gammopathy. He showed improved muscle strength after treatment with high-dose melphalan and auto-PBSCT. Considering the recent reports of successful treatment of SLONM, early and correct diagnosis of this condition in association with monoclonal gammopathy is important. SLONM should be added to the list of diseases to consider in the differential diagnosis of progressive muscle weakness with young adult onset. © 2014 Wiley Periodicals, Inc.

  12. Delayed onset of vastii muscle activity in response to rapid postural perturbations following eccentric exercise: a mechanism that underpins knee pain after eccentric exercise?

    Science.gov (United States)

    Hedayatpour, Nosratollah; Falla, Deborah

    2014-03-01

    Appropriate timing of activity of the vastus medialis obliqus (VMO) and vastus lateralis (VL) muscles is a key factor for proper tracking of the patella in the trochlear groove during knee extension. This study investigates the relative timing of activation of the VMO and VL muscles during unexpected perturbations performed before and after eccentric exercise. Surface electromyography signals were recorded from the VMO and VL muscles of the right leg in 11 healthy men during rapid postural perturbations performed at baseline, immediately after eccentric exercise of the quadriceps, and at 24 and 48 h after exercise. Participants stood on a moveable platform during which eight randomised postural perturbations were performed (4 repetitions of 2 perturbation types: 8 cm forward slides, 8 cm backward slides). Before the eccentric exercise, the onset of VMO activity was significantly earlier than the VL muscle (average for both forward and backward perturbations: VMO 39.0±7.1 ms; VL 43.7±7.9 ms). However, the onset of VMO activity was significantly later compared with VL muscle immediately after eccentric exercise and this remained 24 and 48 h after eccentric exercise (average across all postexercise sessions and perturbation directions: VMO 72.3±11.1 ms; VL 56.0±8.2 ms; peccentric exercise and during eccentric exercise-induced muscle soreness up to 48 h later. These observations may help explain the high prevalence of knee disorders after high intensity eccentric exercise.

  13. Physiological Responses to Exercise in Muscle Soreness Resolve%运动中肌肉酸痛生理反应解析

    Institute of Scientific and Technical Information of China (English)

    张锐

    2011-01-01

    分析肌肉酸痛生理反应出现的原因,了解乳酸生成的过程,通过深层次的剖析,使我们进一步清晰了肌肉酸痛和乳酸有着密切关联。也由此使我们知道如何消除或缓解这一现象的出现,为以后的生活、工作、学习提供良好的身体状况。%Analysis of muscle soreness causes physiological responses appear to understand the process of lactate production through in-depth analysis,enables us to clear the muscle pain and lactic acid are closely related.Has thus enabled us to know how to eliminate or alleviate this phenomenon,as later in life,work,study provide a good physical condition.

  14. Spatial variation and inconsistency between estimates of onset of muscle activation from EMG and ultrasound.

    Science.gov (United States)

    Dieterich, Angela V; Botter, Alberto; Vieira, Taian Martins; Peolsson, Anneli; Petzke, Frank; Davey, Paul; Falla, Deborah

    2017-02-08

    Delayed onset of muscle activation can be a descriptor of impaired motor control. Activation onset can be estimated from electromyography (EMG)-registered muscle excitation and from ultrasound-registered muscle motion, which enables non-invasive measurements in deep muscles. However, in voluntary activation, EMG- and ultrasound-detected activation onsets may not correspond. To evaluate this, ten healthy men performed isometric elbow flexion at 20% to 70% of their maximal force. Utilising a multi-channel electrode transparent to ultrasound, EMG and M(otion)-mode ultrasound were recorded simultaneously over the biceps brachii muscle. The time intervals between automated and visually estimated activation onsets were correlated with the regional variation of EMG and muscle motion onset, contraction level and speed. Automated and visual onsets indicated variable time intervals between EMG- and motion onset, median (interquartile range) 96 (121) ms and 48 (72) ms, respectively. In 17% (computed analysis) or 23% (visual analysis) of trials, motion onset was detected before local EMG onset. Multi-channel EMG and M-mode ultrasound revealed regional differences in activation onset, which decreased with higher contraction speed (Spearman ρ ≥ 0.45, P explain the high variation of the time intervals between local EMG- and ultrasound-detected activation onset.

  15. Location and sequence of muscle onset in deep abdominal muscles measured by different modes of ultrasound imaging.

    Science.gov (United States)

    Westad, Christian; Mork, Paul J; Vasseljen, Ottar

    2010-10-01

    Various modes of ultrasound (US) imaging have been introduced as an alternative to electromyography for determining muscle onset. The purpose of this study was to compare the agreement between US motion-mode (US(m-mode)) and US strain rate (US(SR)) derived from tissue velocity imaging in determining latency time, location and sequence of muscle onset in abdominal muscles using the same data set (contractions). Twenty-four subjects performed four rapid arm flexions in response to a light signal while US recordings were made from the abdominal muscles on the contralateral side. The examined muscles were transversus abdominis (TrA), superficial and deep obliquus internus abdominis (OI(deep) and OI(sup)), and obliquus externus abdominis (OE). The results showed that the two methods detected the first muscle onset on average within 0.1 ms (95% CI; +/-1.4 ms) of each other. US(SR) detected the second muscle onset on average 27 ms after US(m-mode). While US(SR) and US(m-mode) can be used interchangeably to detect the first muscle onset, the location of both first onset and subsequent muscle onsets can be reliably detected by US(SR) only. Furthermore, this study indicates that OI may be functionally subdivided into a superficial and deep region, with onset in OI(deep) occurring on average 53 ms before OI(sup). First onset was detected more frequently in OI than in TrA (65% versus 25% of detected onsets, 10% were equal).

  16. Sore Society

    DEFF Research Database (Denmark)

    Fausing, Bent

    2014-01-01

    This is not brand new; in fact, I do not even mention the word selfie. However, it was very rewarding for me in terms of the intellectual and emotional richness and challenge, I got in return from working with this article and the questions and the answers it deals with. Maybe it will be good...... for you, too, now. Furthermore I write in the beginning: “The characteristics of digital images and the use Orlan makes of them, as well as the crisis in representation that she and the media mark, are linked with the notion of 'sore society’. Why is there a displacement from representation towards...

  17. Effects of acute postexercise chocolate milk consumption during intensive judo training on the recovery of salivary hormones, salivary SIgA, mood state, muscle soreness, and judo-related performance.

    Science.gov (United States)

    Papacosta, Elena; Nassis, George P; Gleeson, Michael

    2015-11-01

    This study examined the effects of postexercise chocolate milk (CM) or water (W) consumption during 5 days of intensive judo training with concomitant weight loss on salivary cortisol and testosterone, salivary secretory immunoglobulin A (SIgA), delayed-onset muscle soreness (DOMS), and judo-related performance. Twelve trained male judo athletes engaged in 5 days of intensive judo training followed by a simulated judo competition, on 2 separate training weeks 14 days apart. The athletes consumed 1000 mL of W (week 1) or CM (week 2) immediately post-training. During both weeks, athletes were instructed to "make weight" for the upcoming competition. Performance in timed push-ups and the Special Judo Fitness Test improved by 14.6% and 6.8%, respectively, at the end of the training week with CM consumption (both p 0.05). Body mass decreased by 1.9% in the W condition and by 1.1% in the CM condition, with no significant difference between treatments. This study indicates that postexercise CM consumption during short-term intensive judo training enhances aspects of recovery without affecting intentional weight loss.

  18. Rocuronium as muscle relaxant for electroconvulsive therapy in a patient with adult-onset muscular dystrophy.

    Science.gov (United States)

    Bryson, Ethan O; Aloysi, Amy S; Katz, Maya; Popeo, Dennis; Kellner, Charles H

    2011-12-01

    Adult-onset muscular dystrophy is an inherited myopathy characterized by a variable degree of progressive muscle weakness and degeneration. Although not usually fatal, significant muscle weakness results in an up-regulation of acetylcholine receptors on the less responsive postjunctional muscles. The resulting profound potassium release when these receptors are stimulated by the depolarizing muscle relaxant succinylcholine can result in potentially fatal cardiac arrhythmias. We report a case of electroconvulsive therapy safely administered in a 61-year-old man with adult-onset muscular dystrophy requiring muscle relaxation with rocuronium.

  19. The effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: a randomized, double-blind, crossover study

    Directory of Open Access Journals (Sweden)

    Golem Devon L

    2010-02-01

    Full Text Available Abstract Background Muscle soreness and decreased performance often follow a bout of high-intensity exercise. By reducing these effects, an athlete can train more frequently and increase long-term performance. The purpose of this study is to examine whether a high-potency, black tea extract (BTE alters the delayed onset muscle soreness (DOMS, oxidative stress, inflammation, and cortisol (CORT responses to high-intensity anaerobic exercise. Methods College-age males (N = 18 with 1+ yrs of weight training experience completed a double-blind, placebo-controlled, crossover study. Subjects consumed the BTE (1,760 mg BTE·d-1 or placebo (PLA for 9 days. Each subject completed two testing sessions (T1 & T2, which occurred on day 7 of the intervention. T1 & T2 consisted of a 30 s Wingate Test plus eight 10 s intervals. Blood samples were obtained before, 0, 30 & 60 min following the interval sessions and were used to analyze the total to oxidized glutathione ratio (GSH:GSSG, 8-isoprostane (8-iso, CORT, and interleukin 6 (IL-6 secretion. DOMS was recorded at 24 & 48 h post-test using a visual analog scale while BTE or PLA continued to be administered. Significance was set at P . Results Compared to PLA, BTE produced significantly higher average peak power (P = 0.013 and higher average mean power (P = 0.067 across nine WAnT intervals. BTE produced significantly lower DOMS compared to PLA at 24 h post test (P and 48 h post test (P . Compared to PLA, BTE had a slightly higher GSH:GSSG ratio at baseline which became significantly higher at 30 and 60 min post test (P . AUC analysis revealed BTE to elicit significantly lower GSSG secretion (P = 0.009, significantly higher GSH:GSSG ratio (P = 0.001, and lower CORT secretion (P = 0.078 than PLA. AUC analysis did not reveal a significant difference in total IL-6 response (P = 0.145 between conditions. Conclusions Consumption of theaflavin-enriched black tea extract led to improved recovery and a reduction in

  20. The effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: a randomized, double-blind, crossover study

    Science.gov (United States)

    2010-01-01

    Background Muscle soreness and decreased performance often follow a bout of high-intensity exercise. By reducing these effects, an athlete can train more frequently and increase long-term performance. The purpose of this study is to examine whether a high-potency, black tea extract (BTE) alters the delayed onset muscle soreness (DOMS), oxidative stress, inflammation, and cortisol (CORT) responses to high-intensity anaerobic exercise. Methods College-age males (N = 18) with 1+ yrs of weight training experience completed a double-blind, placebo-controlled, crossover study. Subjects consumed the BTE (1,760 mg BTE·d-1) or placebo (PLA) for 9 days. Each subject completed two testing sessions (T1 & T2), which occurred on day 7 of the intervention. T1 & T2 consisted of a 30 s Wingate Test plus eight 10 s intervals. Blood samples were obtained before, 0, 30 & 60 min following the interval sessions and were used to analyze the total to oxidized glutathione ratio (GSH:GSSG), 8-isoprostane (8-iso), CORT, and interleukin 6 (IL-6) secretion. DOMS was recorded at 24 & 48 h post-test using a visual analog scale while BTE or PLA continued to be administered. Significance was set at P < 0.05. Results Compared to PLA, BTE produced significantly higher average peak power (P = 0.013) and higher average mean power (P = 0.067) across nine WAnT intervals. BTE produced significantly lower DOMS compared to PLA at 24 h post test (P < 0.001) and 48 h post test (P < 0.001). Compared to PLA, BTE had a slightly higher GSH:GSSG ratio at baseline which became significantly higher at 30 and 60 min post test (P < 0.002). AUC analysis revealed BTE to elicit significantly lower GSSG secretion (P = 0.009), significantly higher GSH:GSSG ratio (P = 0.001), and lower CORT secretion (P = 0.078) than PLA. AUC analysis did not reveal a significant difference in total IL-6 response (P = 0.145) between conditions. Conclusions Consumption of theaflavin-enriched black tea extract led to improved recovery and a

  1. No Differences Between Alter G-Trainer And Active And Passive Recovery Strategies On Isokinetic Strength, Systemic Oxidative Stress And Perceived Muscle Soreness After Exercise-Induced Muscle Damage.

    Science.gov (United States)

    Cooke, Matthew B; Nix, Carrie; Greenwood, Lori; Greenwood, Mike

    2016-11-28

    The incidence of muscle injuries is prevalent in elite sport athletes as well as weekend warriors and strategies that safely and effectively hasten recovery are highly desirable. The purpose of this study was to examine the differences between three recovery methods after eliciting muscle damage in recreationally active men relative to maximal isokinetic contractions, perceived muscle soreness and psychological mood states. Twenty-five recreationally active men (22.15±3.53yrs, 75.75±11.91kg, 180.52±7.3cm) were randomly matched by VO2 peak (53.86±6.65ml·kg·min) and assigned to one of three recovery methods: Anti-gravity Treadmill (G-Trainer) (N = 8), Conventional Treadmill (N = 8) or Static Stretching (N = 9). Recovery methods were performed 30 minutes, 24, 48 and 72 hours following a 45 minute downhill run. Following eccentrically-biased running, no significant differences were noted in isokinetic knee flexion and extension peak torque, systemic markers of muscle damage, oxidative stress and lipid peroxidation such as serum creatine kinase (CK), superoxide dismutase (SOD), and malondialdehyde (MDA), respectively, and subjective ratings of perceived muscle soreness between recovery methods. The G-Trainer group did however display a higher mood state as indicated by the Profile of Mood State global scores at 24 hours post-exercise when compared to the conventional treadmill recovery group (p=0.035). The improved mood state following the use of the anti-gravity treadmill may provide clinical relevance to other populations.

  2. Borderlines between sarcopenia and mild late-onset muscle disease

    Directory of Open Access Journals (Sweden)

    Johanna ePalmio

    2014-09-01

    Full Text Available Numerous natural or disease-related alterations occur in different tissues of the body with advancing age. Sarcopenia is defined as age-related decrease of muscle mass and strength beginning in mid-adulthood and accelerating in people older than 60 years. Pathophysiology of sarcopenia involves both neural and muscle dependent mechanisms and is enhanced by multiple factors. Aged muscles show loss in fiber number, fiber atrophy and gradual increase in the number of ragged red fibers and cytochrome c oxidase-negative fibers. Generalized loss of muscle tissue and increased amount of intramuscular fat is seen on muscle imaging. However, the degree of these changes vary greatly between individuals and the distinction between normal age-related weakening of muscle strength and clinically significant muscle disease is not always obvious. Because some of the genetic myopathies can present at a very late age and be mild in severity, the correct diagnosis is easily missed. We highlight this difficult borderline zone between sarcopenia and muscle disease by two examples: LGMD1D and myotonic dystrophy type 2. Muscle MRI is a useful tool to help differentiate myopathies from sarcopenia and to reach the correct diagnosis also in the elderly.

  3. Computer-Based Algorithmic Determination of Muscle Movement Onset Using M-Mode Ultrasonography

    Science.gov (United States)

    2017-04-01

    from baseline. Computerized algorithms Computed MO was determined by three separate classes of algorithms using RStudio: (i) a novel standard...ARL-RP-0596 ● APR 2017 US Army Research Laboratory Computer -Based Algorithmic Determination of Muscle Movement Onset Using M...the originator. ARL-RP-0596 ● APR 2017 US Army Research Laboratory Computer -Based Algorithmic Determination of Muscle Movement

  4. A randomised trial comparing the efficacy and safety of topical ketoprofen in Transfersome(®) gel (IDEA-033) with oral ketoprofen and drug-free ultra-deformable Sequessome™ vesicles (TDT 064) for the treatment of muscle soreness following exercise.

    Science.gov (United States)

    Seidel, Egbert J; Rother, Matthias; Regenspurger, Katja; Rother, Ilka

    2016-01-01

    We compared the effectiveness of topical ketoprofen in Transfersome(®) gel (IDEA-033) with oral ketoprofen and drug-free Sequessome™ vesicles (FLEXISEQ(®) Sport; TDT 064) in reducing calf muscle soreness. One hundred and sixty eight healthy individuals with a pain score ≥ 3 (10-point scale) 12-16 h post-exercise (walking down stairs with an altitude of 300-400 m) were randomised to receive IDEA-033 plus oral placebo (two dose groups), oral ketoprofen plus TDT 064, or TDT 064 plus oral placebo. The primary endpoint was muscle soreness reduction from pre-dosing to Day 7. Higher pain scores were recorded with oral ketoprofen plus TDT 064 (mean ± s 462.4 ± 160.4) versus IDEA-033 plus oral placebo (434.7 ± 190.8; P = 0.2931) or TDT 064 plus oral placebo (376.2 ± 159.1; P = 0.0240) in the 7 days post-exercise. Recovery from muscle soreness was longer with oral ketoprofen plus TDT 064 (mean 91.0 ± 19.5 h) versus IDEA-033 plus placebo (mean 81.4 ± 22.9 h; P = 0.5964) or TDT 064 plus placebo (mean 78.9 ± 22.8 h; P = 0.0262). In conclusion, ultradeformable phospholipid vesicles ± ketoprofen did not retard recovery from muscle soreness. TDT 064 improves osteoarthritis-related pain and could be of interest as a treatment for joint pain during and post-exercise.

  5. Isokinetic eccentric exercise as a model to induce and reproduce pathophysiological alterations related to delayed onset muscle soreness

    DEFF Research Database (Denmark)

    Lund, Henrik; Vestergaard-Poulsen, P; Kanstrup, I.L.

    1998-01-01

    Physiological alterations following unaccustomed eccentric exercise in an isokinetic dynamometer of the right m. quadriceps until exhaustion were studied, in order to create a model in which the physiological responses to physiotherapy could be measured. In experiment I (exp. I), seven selected...... parameters were measured bilaterally in 7 healthy subjects at day 0 as a control value. Then after a standardized bout of eccentric exercise the same parameters were measured daily for the following 7 d (test values). The measured parameters were: the ratio of phosphocreatine to inorganic phosphate (PCr...... (133Xenon washout technique). This was repeated in experiment II (exp. II) 6-12 months later in order to study reproducibility. In experiment III (exp. III), the normal fluctuations over 8 d of the seven parameters were measured, without intervention with eccentric exercise in 6 other subjects. All...

  6. Review of Delayed-Onset Muscle Soreness%延迟性肌肉酸痛研究进展

    Institute of Scientific and Technical Information of China (English)

    孟隽卿

    2013-01-01

    机体进行大强度或不适应的运动,尤其是离心运动后,常伴随出现延迟性肌肉酸痛,运动后2~3天酸痛达到高峰,肌肉在解剖学、组织学及生化等方面会产生一系列变化,这些变化严重时将直接影响健身及训练效果.因此,文章拟对国内外有关延迟性肌肉酸痛的诱发模型、产生机制及最新的治疗方法进行综述,为指导大众健身和运动训练提供理论支持和实际应用价值.

  7. Increased muscle tension and reduced elasticity of affected muscles in recent-onset Graves' disease caused primarily by active muscle contraction

    NARCIS (Netherlands)

    H.J. Simonsz (Huib); G. Kommerell (Guntram)

    1989-01-01

    textabstractIn 3 patients with Graves' disease of recent onset, length-tension diagrams were made during surgery for squint under eyedrop anesthesia. The affected muscles were found to be very stiff when the other eye looked straight ahead. It was expected that these stiff muscles would be able to

  8. Increased muscle tension and reduced elasticity of affected muscles in recent-onset Graves' disease caused primarily by active muscle contraction

    NARCIS (Netherlands)

    H.J. Simonsz (Huib); G. Kommerell (Guntram)

    1989-01-01

    textabstractIn 3 patients with Graves' disease of recent onset, length-tension diagrams were made during surgery for squint under eyedrop anesthesia. The affected muscles were found to be very stiff when the other eye looked straight ahead. It was expected that these stiff muscles would be able to s

  9. Comparison of the effects of electrical stimulation and cold-water immersion on muscle soreness after resistance exercise.

    Science.gov (United States)

    Jajtner, Adam R; Hoffman, Jay R; Gonzalez, Adam M; Worts, Phillip R; Fragala, Maren S; Stout, Jeffrey R

    2015-05-01

    Resistance training is a common form of exercise for competitive and recreational athletes. Enhancing recovery from resistance training may improve the muscle-remodeling processes, stimulating a faster return to peak performance. To examine the effects of 2 different recovery modalities, neuromuscular electrical stimulation (NMES) and cold-water immersion (CWI), on performance and biochemical and ultrasonographic measures. Thirty resistance-trained men (23.1 ± 2.9 y, 175.2 ± 7.1 cm, 82.1 ± 8.4 kg) were randomly assigned to NMES, CWI, or control (CON). All participants completed a high-volume lower-body resistance-training workout on d 1 and returned to the human performance laboratory 24 (24H) and 48 h (48 H) postexercise for follow-up testing. Blood samples were obtained preexercise (PRE) and immediately (IP), 30 min (30 P), 24 h (24H), and 48 h (48 H) post. Subjects were examined for performance changes in the squat exercise (total repetitions and average power per repetition), biomarkers of inflammation, and changes in cross-sectional area and echo intensity (EI) of the rectus femoris (RF) and vastus lateralis muscles. No differences between groups were observed in the number of repetitions (P = .250; power: P = .663). Inferential-based analysis indicated that increases in C-reactive protein concentrations were likely increased by a greater magnitude after CWI compared with CON, while NMES possibly decreased more than CON from IP to 24H. Increases in interleukin-10 concentrations between IP and 30 P were likely greater in CWI than NMES but not different from CON. Inferential-based analysis of RF EI indicated a likely decrease for CWI between IP and 48 H. No other differences between groups were noted in any other muscle-architecture measures. Results indicated that CWI induced greater increases in pro- and anti-inflammatory markers, while decreasing RF EI, suggesting that CWI may be effective in enhancing short-term muscle recovery after high-volume bouts of

  10. Practical Recommendations for Diagnosis and Management of Respiratory Muscle Weakness in Late-Onset Pompe Disease

    Directory of Open Access Journals (Sweden)

    Matthias Boentert

    2016-10-01

    Full Text Available Pompe disease is an autosomal-recessive lysosomal storage disorder characterized by progressive myopathy with proximal muscle weakness, respiratory muscle dysfunction, and cardiomyopathy (in infants only. In patients with juvenile or adult disease onset, respiratory muscle weakness may decline more rapidly than overall neurological disability. Sleep-disordered breathing, daytime hypercapnia, and the need for nocturnal ventilation eventually evolve in most patients. Additionally, respiratory muscle weakness leads to decreased cough and impaired airway clearance, increasing the risk of acute respiratory illness. Progressive respiratory muscle weakness is a major cause of morbidity and mortality in late-onset Pompe disease even if enzyme replacement therapy has been established. Practical knowledge of how to detect, monitor and manage respiratory muscle involvement is crucial for optimal patient care. A multidisciplinary approach combining the expertise of neurologists, pulmonologists, and intensive care specialists is needed. Based on the authors’ own experience in over 200 patients, this article conveys expert recommendations for the diagnosis and management of respiratory muscle weakness and its sequelae in late-onset Pompe disease.

  11. The Onset of Acute Sore Throat Characteristics and Nursing Measures%急性咽喉炎的发病特征与护理措施探究

    Institute of Scientific and Technical Information of China (English)

    潘薇

    2016-01-01

    目的:分析探讨急性咽喉炎的发病特征与护理措施。方法选取2013年7月至2015年7月天津市环湖医院收治的急性咽喉炎患者100例,对患者发病特征进行总结。随机方法分组(对照组50例,试验组50例)。对照组患者行常规护理,试验组患者行综合护理。对比分析两组患者满意率、治疗效果、并发症发生率、住院天数的差异。结果经总结,100例急性咽喉炎患者中,男女比例无显著差异,高发季节为冬春季,高发年龄为30~69岁之间,高发因素为烟酒、辛辣食物刺激和有害气体或粉尘刺激。经护理,试验组患者并发症发生率明显低于对照组,满意率明显高于对照组,治疗效果明显优于对照组,住院天数明显短于对照组,组间差异显著( P<0.05)。结论急性咽喉炎在冬春季节多发,多为食物或气体、粉尘刺激所致,在中老年中发病率较高,辅以综合护理干预,可有效提高治疗效果,减少并发症,缩短住院时间,提升患者满意度,值得推广。%Objective Analysis to study the clinical characteristics and nursing measures of acute sore throat.Methods Included in July 2013 to July 2015 of our hospital, 100 patients with acute laryngitis, to summarize characteristics of the patient is sick.Random grouping method 50 cases ( the control group, 50 cases of test group) .The control group atients with routine nursing care, experimental group patients comprehensive nursing.Analysis of two groups of patients'satisfaction, treatment effect, the differences between the incidence of complications and hospitalization days.Results Through summary, 100 cases of patients with acute sore throat, no significant difference, the sex ratio for winter season, high-risk aged 30~69 years old, high-risk factors for alcohol and tobacco, spicy food stimulation and harmful gases or dust.Through nursing, complication rates significantly lower than

  12. Analysis of statistical and standard algorithms for detecting muscle onset with surface electromyography.

    Science.gov (United States)

    Tenan, Matthew S; Tweedell, Andrew J; Haynes, Courtney A

    2017-01-01

    The timing of muscle activity is a commonly applied analytic method to understand how the nervous system controls movement. This study systematically evaluates six classes of standard and statistical algorithms to determine muscle onset in both experimental surface electromyography (EMG) and simulated EMG with a known onset time. Eighteen participants had EMG collected from the biceps brachii and vastus lateralis while performing a biceps curl or knee extension, respectively. Three established methods and three statistical methods for EMG onset were evaluated. Linear envelope, Teager-Kaiser energy operator + linear envelope and sample entropy were the established methods evaluated while general time series mean/variance, sequential and batch processing of parametric and nonparametric tools, and Bayesian changepoint analysis were the statistical techniques used. Visual EMG onset (experimental data) and objective EMG onset (simulated data) were compared with algorithmic EMG onset via root mean square error and linear regression models for stepwise elimination of inferior algorithms. The top algorithms for both data types were analyzed for their mean agreement with the gold standard onset and evaluation of 95% confidence intervals. The top algorithms were all Bayesian changepoint analysis iterations where the parameter of the prior (p0) was zero. The best performing Bayesian algorithms were p0 = 0 and a posterior probability for onset determination at 60-90%. While existing algorithms performed reasonably, the Bayesian changepoint analysis methodology provides greater reliability and accuracy when determining the singular onset of EMG activity in a time series. Further research is needed to determine if this class of algorithms perform equally well when the time series has multiple bursts of muscle activity.

  13. Effect of muscle mass on muscle mechanoreflex-mediated heart rate increase at the onset of dynamic exercise.

    Science.gov (United States)

    Vianna, Lauro C; Oliveira, Ricardo B; Ramos, Plínio S; Ricardo, Djalma R; Araújo, Claudio Gil S

    2010-02-01

    This study was conducted to determine whether the heart rate increase at the onset of passive dynamic exercise is related to the amount of skeletal muscle mass engaged in movement. Fifteen healthy male subjects, 18-30 years old, performed, from the 4th to the 8th second of a 12-s apnea, four different 4-s bouts of passive cycling assigned in a counterbalanced order, each one different from the others by the number of limbs engaged in the movement (i.e., 1 arm, 2 arms, 2 arms + 1 leg and 2 arms + 2 legs), while respiratory movements and limb muscle electromyography were recorded. A repeated-measures ANOVA showed that the RR interval at the end of 4-s passive cycling was reduced in all the four different bouts (P exercise to the end of 4 s of passive cycling) were directly related, in a non-linear trend, to the amount of muscle mass engaged in movement. These variations were more expressive when extremes were compared (110 +/- 16 vs. 184 +/- 24 ms, respectively, 1 limb vs. 4 limbs, P exercise. It was concluded that in healthy subjects, heart rate increase at the onset of passive cycling is directly related to the number of limbs and consequently the amount of muscle mass engaged, which is possibly related to a greater afferent input from stretch-sensitive muscle mechanoreceptors.

  14. Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake

    DEFF Research Database (Denmark)

    Nyberg, Michael Permin; Mortensen, Stefan Peter; Saltin, Bengt

    2010-01-01

    The effect of low blood flow at onset of moderate intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5 minute one-legged knee-extensor exercise bout (24+/-1 (+/-S.D.) W) without (CON) and with (double blockade; DB) arterial infusion of i...

  15. Photobiomodulation delays the onset of skeletal muscle fatigue in a dose-dependent manner.

    Science.gov (United States)

    Larkin-Kaiser, Kelly A; Borsa, Paul A; Baweja, Harsimran S; Moore, Molly A; Tillman, Mark D; George, Steven Z; Christou, Evangelos A

    2016-09-01

    Photobiomodulation (PBM) therapy has been implicated as an effective ergogenic aid to delay the onset of muscle fatigue. The purpose of this study was to examine the dose-response ergogenic properties of PBM therapy and its ability to prolong time to task failure by enhancing muscle activity and delaying the onset of muscle fatigue using a static positioning task. Nine participants (24.3 ± 4.9 years) received three doses of near-infrared (NIR) light therapy randomly on three separate sessions (sham, 240, and 480 J). For the positioning task, participants held a 30 % one-repetition maximum (1-RM) load using the index finger until volitional fatigue. Surface electromyography (sEMG) of the first dorsal interosseous muscle was recorded for the length of the positioning task. Outcomes included time to task failure (TTF), muscle fatigue, movement accuracy, motor output variability, and muscle activity (sEMG). The 240-J dose significantly extended TTF by 26 % (p = 0.032) compared with the sham dose. TTF for the 240-J dose was strongly associated with a decrease in muscle fatigue (R (2) = 0.54, p = 0.024). Our findings show that a 240-J dose of NIR light therapy is efficacious in delaying the onset and extent of muscle fatigue during submaximal isometric positioning tasks. Our findings suggest that NIR light therapy may be used as an ergogenic aid during functional tasks or post-injury rehabilitation.

  16. Effect of experimental chewing on masticatory muscle pain onset

    Directory of Open Access Journals (Sweden)

    Paulo César Rodrigues Conti

    2011-02-01

    Full Text Available OBJECTIVES: To evaluate the effect of a chewing exercise on pain intensity and pressure-pain threshold in patients with myofascial pain. METHODS: Twenty-nine consecutive women diagnosed with myofascial pain (MFP according to the Research Diagnostic Criteria comprised the experimental group and 15 healthy age-matched female were used as controls. Subjects were asked to chew a gum stick for 9 min and to stay at rest for another 9 min afterwards. Pain intensity was rated on a visual analog scale (VAS every 3 min. At 0, 9 and 18 min, the pressure-pain threshold (PPT was measured bilaterally on the masseter and the anterior, medium, and posterior temporalis muscles. RESULTS: Patients with myofascial pain reported increase (76% and no change (24% on the pain intensity measured with the VAS. A reduction of the PPT at all muscular sites after the exercise and a non-significant recovery after rest were also observed. CONCLUSION: The following conclusions can be drawn: 1. there are at least two subtypes of patients with myofascial pain that respond differently to experimental chewing; 2. the chewing protocol had an adequate discriminative ability in distinguishing patients with myofascial pain from healthy controls.

  17. Cold Sores (HSV-1)

    Science.gov (United States)

    ... A Week of Healthy Breakfasts Shyness Cold Sores (HSV-1) KidsHealth > For Teens > Cold Sores (HSV-1) A A A What's in this article? ... or around a person's lips, are caused by herpes simplex virus-1 (HSV-1) . But they don't ...

  18. Sore Throat: Treatment

    Science.gov (United States)

    ... for a sore throat are often packaged as teas, sprays or lozenges. Common alternative remedies include: Slippery ... Clinic does not endorse any of the third party products and services advertised. Advertising and sponsorship policy ...

  19. Canker Sores (For Parents)

    Science.gov (United States)

    ... such as potato chips and nuts, which can irritate gums and other delicate mouth tissues try brushing ... foods (such as lemons and tomatoes), which can irritate tender mouth sores Reviewed by: Patricia Solo-Josephson, ...

  20. Pain-evoked trunk muscle activity changes during fatigue and DOMS

    DEFF Research Database (Denmark)

    Larsen, Lars Henrik; Hirata, Rogerio Pessoto; Graven-Nielsen, Thomas

    2017-01-01

    abdominal and back muscles. RESULTS: In DOMS, peak VAS scores were higher during bilateral control and bilateral saline-induced pain than fatigue (p ...-perturbation Delta-RMS-EMG in back muscles was higher during bilateral pain and lower during unilateral pain (p abdominal Delta-RMS-EMG was not significantly affected. CONCLUSION: Facilitated and attenuated back muscle responses to surface perturbations in bilateral and unilateral LBP, respectively......BACKGROUND: Muscle pain may reorganize trunk muscle activity but interactions with exercise-related muscle fatigue and delayed onset muscle soreness (DOMS) is to be clarified. METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface...

  1. Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.

    Science.gov (United States)

    Justiniano, Maria; Dold, Sylvia; Espinoza, Luis R

    2007-10-01

    We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis. Profound muscle weakness of lower extremities with inability to stand up and/or walk was present. Elevated muscle enzymes and findings on electromyography were consistent with myopathy. Rapid improvement in muscle strength accompanied by prompt resolution of abnormal elevation of muscle enzymes followed cessation of both medications. Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy. The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness. Four patients with similar clinical and laboratory characteristics to our patient's after the combined use of colchicine and statins have been described in the literature. Patients receiving combination therapy with colchicine and simvastatin, particularly in the presence of renal insufficiency, should be monitored for the development of myopathy, including rhabdomyolysis.

  2. Increased inspiratory and expiratory muscle strength following respiratory muscle strength training (RMST) in two patients with late-onset Pompe disease.

    Science.gov (United States)

    Jones, Harrison N; Moss, Tronda; Edwards, Laurie; Kishnani, Priya S

    2011-11-01

    Respiratory muscle strength training (RMST) is an exercise-based intervention which targets respiratory muscle weakness. We implemented RMST in two patients with late-onset Pompe disease (LOPD), both who had received long-term enzyme replacement therapy and had severe respiratory weakness. Over 16-32 weeks, inspiratory muscle strength increased by 73-74%. Expiratory muscle strength increased 31-48% over 12-22 weeks. These findings suggest that RMST may increase respiratory muscle strength, even in the setting of LOPD and severe baseline weakness.

  3. Herpes Simplex Virus (Cold Sores)

    Science.gov (United States)

    ... Print Share Cold Sores in Children: About the Herpes Simplex Virus Page Content ​A child's toddler and ... Cold sores (also called fever blisters or oral herpes) start as small blisters that form around the ...

  4. Reduced short-interval intracortical inhibition after eccentric muscle damage in human elbow flexor muscles.

    Science.gov (United States)

    Pitman, Bradley M; Semmler, John G

    2012-09-01

    The purpose of this study was to use paired-pulse transcranial magnetic stimulation (TMS) to examine the effect of eccentric exercise on short-interval intracortical inhibition (SICI) after damage to elbow flexor muscles. Nine young (22.5 ± 0.6 yr; mean ± SD) male subjects performed maximal eccentric exercise of the elbow flexor muscles until maximal voluntary contraction (MVC) force was reduced by ∼40%. TMS was performed before, 2 h after, and 2 days after exercise under Rest and Active (5% MVC) conditions with motor-evoked potentials (MEPs) recorded from the biceps brachii (BB) muscle. Peripheral electrical stimulation of the brachial plexus was used to assess maximal M-waves, and paired-pulse TMS with a 3-ms interstimulus interval was used to assess changes in SICI at each time point. The eccentric exercise resulted in a 34% decline in strength (P muscle strength (27%, P muscle soreness (P muscle damage. When the test MEP amplitudes were matched between sessions, we found that SICI was reduced by 27% in resting and 23% in active BB muscle 2 h after exercise. SICI recovered 2 days after exercise when muscle pain and soreness were present, suggesting that delayed onset muscle soreness from eccentric exercise does not influence SICI. The change in SICI observed 2 h after exercise suggests that eccentric muscle damage has widespread effects throughout the motor system that likely includes changes in motor cortex.

  5. Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders.

    Science.gov (United States)

    Jokela, Manu; Huovinen, Sanna; Raheem, Olayinka; Lindfors, Mikaela; Palmio, Johanna; Penttilä, Sini; Udd, Bjarne

    2016-01-01

    The objective of this study was to characterize and compare muscle histopathological findings in 3 different genetic motor neuron disorders. We retrospectively re-assessed muscle biopsy findings in 23 patients with autosomal dominant lower motor neuron disease caused by p.G66V mutation in CHCHD10 (SMAJ), 10 X-linked spinal and bulbar muscular atrophy (SBMA) and 11 autosomal dominant c9orf72-mutated amyotrophic lateral sclerosis (c9ALS) patients. Distinct large fiber type grouping consisting of non-atrophic type IIA muscle fibers were 100% specific for the late-onset spinal muscular atrophies (SMAJ and SBMA) and were never observed in c9ALS. Common, but less specific findings included small groups of highly atrophic rounded type IIA fibers in SMAJ/SBMA, whereas in c9ALS, small group atrophies consisting of small-caliber angular fibers involving both fiber types were more characteristic. We also show that in the 2 slowly progressive motor neuron disorders (SMAJ and SBMA) the initial neurogenic features are often confused with considerable secondary "myopathic" changes at later disease stages, such as rimmed vacuoles, myofibrillar aggregates and numerous fibers reactive for fetal myosin heavy chain (dMyHC) antibodies. Based on our findings, muscle biopsy may be valuable in the diagnostic work-up of suspected motor neuron disorders in order to avoid a false ALS diagnosis in patients without clear findings of upper motor neuron lesions.

  6. Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders.

    Directory of Open Access Journals (Sweden)

    Manu Jokela

    Full Text Available The objective of this study was to characterize and compare muscle histopathological findings in 3 different genetic motor neuron disorders. We retrospectively re-assessed muscle biopsy findings in 23 patients with autosomal dominant lower motor neuron disease caused by p.G66V mutation in CHCHD10 (SMAJ, 10 X-linked spinal and bulbar muscular atrophy (SBMA and 11 autosomal dominant c9orf72-mutated amyotrophic lateral sclerosis (c9ALS patients. Distinct large fiber type grouping consisting of non-atrophic type IIA muscle fibers were 100% specific for the late-onset spinal muscular atrophies (SMAJ and SBMA and were never observed in c9ALS. Common, but less specific findings included small groups of highly atrophic rounded type IIA fibers in SMAJ/SBMA, whereas in c9ALS, small group atrophies consisting of small-caliber angular fibers involving both fiber types were more characteristic. We also show that in the 2 slowly progressive motor neuron disorders (SMAJ and SBMA the initial neurogenic features are often confused with considerable secondary "myopathic" changes at later disease stages, such as rimmed vacuoles, myofibrillar aggregates and numerous fibers reactive for fetal myosin heavy chain (dMyHC antibodies. Based on our findings, muscle biopsy may be valuable in the diagnostic work-up of suspected motor neuron disorders in order to avoid a false ALS diagnosis in patients without clear findings of upper motor neuron lesions.

  7. Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders

    Science.gov (United States)

    Jokela, Manu; Huovinen, Sanna; Raheem, Olayinka; Lindfors, Mikaela; Palmio, Johanna; Penttilä, Sini; Udd, Bjarne

    2016-01-01

    The objective of this study was to characterize and compare muscle histopathological findings in 3 different genetic motor neuron disorders. We retrospectively re-assessed muscle biopsy findings in 23 patients with autosomal dominant lower motor neuron disease caused by p.G66V mutation in CHCHD10 (SMAJ), 10 X-linked spinal and bulbar muscular atrophy (SBMA) and 11 autosomal dominant c9orf72-mutated amyotrophic lateral sclerosis (c9ALS) patients. Distinct large fiber type grouping consisting of non-atrophic type IIA muscle fibers were 100% specific for the late-onset spinal muscular atrophies (SMAJ and SBMA) and were never observed in c9ALS. Common, but less specific findings included small groups of highly atrophic rounded type IIA fibers in SMAJ/SBMA, whereas in c9ALS, small group atrophies consisting of small-caliber angular fibers involving both fiber types were more characteristic. We also show that in the 2 slowly progressive motor neuron disorders (SMAJ and SBMA) the initial neurogenic features are often confused with considerable secondary “myopathic” changes at later disease stages, such as rimmed vacuoles, myofibrillar aggregates and numerous fibers reactive for fetal myosin heavy chain (dMyHC) antibodies. Based on our findings, muscle biopsy may be valuable in the diagnostic work-up of suspected motor neuron disorders in order to avoid a false ALS diagnosis in patients without clear findings of upper motor neuron lesions. PMID:26999347

  8. Medial circumflex femoral artery flap for ischial pressure sore

    Science.gov (United States)

    Palanivelu, S.

    2009-01-01

    A new axial pattern flap based on the terminal branches of the medial circumflex femoral artery is described for coverage of ischial pressure sore. Based on the terminal branches of the transverse branch of medial circumflex femoral artery, which exit through the gap between the quadratus femoris muscle above and the upper border of adductor magnus muscle below, this fascio cutaneous flap is much smaller than the posterior thigh flap but extremely useful to cover ischeal pressure sores. The skin redundancy below the gluteal fold allows a primary closure of the donor defect. It can also be used in combination with biceps femoris muscle flap. PMID:19881020

  9. Bedsores (Pressure Sores)

    Science.gov (United States)

    Bedsores (pressure ulcers) Overview By Mayo Clinic Staff Bedsores — also called pressure ulcers and decubitus ulcers — are injuries to skin and underlying tissue resulting from prolonged pressure on the skin. Bedsores most ... quickly. Most sores heal with treatment, but some never heal completely. ...

  10. Onset of ischemic colitis following use of electrical muscle stimulation (EMS) exercise equipment.

    Science.gov (United States)

    Tsujimoto, Tatsuhiro; Takano, Masato; Ishikawa, Masatoshi; Tsuruzono, Takuya; Matsumura, Yoshinobu; Kitano, Hiroyuki; Yoneda, Satoshi; Yoshiji, Hitoshi; Yamao, Junichi; Fukui, Hiroshi

    2004-08-01

    Our patient was a 71-year-old man who presented with lower abdominal pain, and bloody and white mucosal stools. He purchased by mail-order an electrical muscle stimulation (EMS) device, which he strapped onto his lower abdomen, and for 2 consecutive days he underwent muscle stimulation comprising 600 contractions at 2.40 mA and 1.20 V over a 10 minute period. He experienced the onset of lower abdominal pain immediately following muscle stimulation on the second day, and then passed stools containing blood and white mucus. The cause was thought to be electrical and mechanical stimulation of the lower abdomen by the EMS equipment, either inducing colonic or vascular spasm, or dislodging thrombi associated with atrial fibrillation or atherosclerosis. This is the first known report of ischemic colitis associated with the use of EMS exercise equipment. We report this case in the belief that this condition is likely to become more common with increasing use of such devices.

  11. Characterizing rapid-onset vasodilation to single muscle contractions in the human leg.

    Science.gov (United States)

    Credeur, Daniel P; Holwerda, Seth W; Restaino, Robert M; King, Phillip M; Crutcher, Kiera L; Laughlin, M Harold; Padilla, Jaume; Fadel, Paul J

    2015-02-15

    Rapid-onset vasodilation (ROV) following single muscle contractions has been examined in the forearm of humans, but has not yet been characterized in the leg. Given known vascular differences between the arm and leg, we sought to characterize ROV following single muscle contractions in the leg. Sixteen healthy men performed random ordered single contractions at 5, 10, 20, 40, and 60% of their maximum voluntary contraction (MVC) using isometric knee extension made with the leg above and below heart level, and these were compared with single isometric contractions of the forearm (handgrip). Single thigh cuff compressions (300 mmHg) were utilized to estimate the mechanical contribution to leg ROV. Continuous blood flow was determined by duplex-Doppler ultrasound and blood pressure via finger photoplethysmography (Finometer). Single isometric knee extensor contractions produced intensity-dependent increases in peak leg vascular conductance that were significantly greater than the forearm in both the above- and below-heart level positions (e.g., above heart level: leg 20% MVC, +138 ± 28% vs. arm 20% MVC, +89 ± 17%; P contractions in the leg. Collectively, these data demonstrate the presence of a rapid and robust vasodilation to single muscle contractions in the leg that is largely independent of mechanical factors, thus establishing the leg as a viable model to study ROV in humans.

  12. Muscle Activity Onset Prior to Landing in Patients after Anterior Cruciate Ligament Injury: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Theisen, Daniel; Rada, Isabel; Brau, Amélie; Gette, Paul; Seil, Romain

    2016-01-01

    Muscle activation during landing is paramount to stabilise lower limb joints and avoid abnormal movement patterns. Delayed muscle activity onset measured by electromyography (EMG) has been suggested to be associated with anterior cruciate ligament (ACL) injury. Therefore, the aim of this systematic review and meta-analysis was to test the hypothesis if ACL-injured patients display different results for muscle onset timing during standard deceleration tasks compared to healthy control participants. PubMed, Embase, Scopus and ScienceDirect databases were systematically searched over the period from January 1980 to February 2015, yielding a total of 1461 citations. Six studies meeting inclusion criteria underwent quality assessment, data extraction and re-computing procedures for the meta-analysis. The quality was rated “moderate” for 2 studies and “poor” for 4. Patients included and procedures used were highly heterogeneous. The tasks investigated were single leg hopping, decelerating from running or walking, tested on a total of 102 ACL-injured participants and 86 controls. EMG analyses of the muscles vastus lateralis, vastus medialis, lateral and medial hamstrings revealed trivial and non-significant standardised mean differences (SMD0.05) between patients and control participants. Furthermore, no differences were found between the contralateral leg of patients and controls for muscle activity onset of the medial and lateral gastrocnemius (SMD0.05). Based on 3 studies, the involved legs of ACL-injured patients showed overall earlier muscle activity onset compared to control participants for the medial gastrocnemius (SMD = 0.5; p = 0.05). Similar results were found for the lateral gastrocnemius (SMD = 2.1; p<0.001), with a greater effect size but based only on a single study. We conclude that there are no differences between leg muscles of ACL-injured patients and healthy controls regarding the muscle activity onset during landing. However, current evidence

  13. Discussion on Muscle Soreness Character and Mitigation of Quick Walking follow Long Jump Athletes%急行跳远运动员肌肉酸痛的特点及缓解方法的探讨

    Institute of Scientific and Technical Information of China (English)

    胡海涛

    2011-01-01

    采用实验法、文献资料和调查问卷法,调查问卷法,调查分析急行跳远产生肌肉酸痛的特点和在运动后拉伸肌肉加小幅度、小负荷、快速运动缓解学生肌肉酸痛的作用。研究结果表明:肌肉酸痛常在运动后8—24小时出现,24—28小时内达到顶点,持续5—7天或更长时间;实验组缓解肌肉酸痛的效果较好,身体素质指标恢复快。%Through using the method of experiment,literature review and questionnaire,this paper analyzes the muscle soreness character of quick walking follow long jump and mitigation by stretch the muscles plus a small margin,small load,fast-moving after exercise.

  14. [Pressure sore revision surgery].

    Science.gov (United States)

    Dorsche, Karin Marion

    2010-02-22

    Pressure sores are a major problem for patients as well as society in general. Immobilised patients are especially at risk. This group of patients with pressure sores should be hospitalised to perform surgical revision of the wound and reconstruction using a flap. Such surgery demands extensive postoperative relief of the flap. The University Centre for Wound Healing at Odense University Hospital has tested the effects of a reduction of the formerly recommended relief period from three to two weeks. In this article we report results covering all patients who have undergone surgery and reconstruction of pressure sores during the period from 1st October 2001 to 1st November 2008. The results are divided into two periods: the period before and the period after the introduction of the reduced relief period. A total of 80 patients were included; 34 in the first period and 46 in the second period. We achieved a considerable reduction in median length of stay from 38 to 27 days with no increase in surgical or complication frequency. Furthermore, the share of fully healed remained unchanged. We believe that there is no risk in shortening the immobile postoperative relief phase following reconstruction of pressure wounds in immobilised patients.

  15. Strenuous resistance exercise effects on magnetic resonance diffusion parameters and muscle-tendon function in human skeletal muscle.

    Science.gov (United States)

    Yanagisawa, Osamu; Kurihara, Toshiyuki; Kobayashi, Naoyuki; Fukubayashi, Toru

    2011-10-01

    To assess the effects of strenuous exercise on magnetic resonance diffusion parameters and muscle-tendon complex function in skeletal muscle. Six men performed ankle plantar flexion exercises with eccentric contraction. The fractional anisotropy (FA), λ(1) , λ(2) , λ(3) , mean diffusivity (MD), and T(2) values in the triceps surae muscles were measured by magnetic resonance diffusion tensor and spin-echo imaging. Passive torque of plantar flexors, maximal voluntary isometric plantar flexion torques (MVIP), and Achilles tendon stiffness during MVIP were measured by combined ultrasonography and dynamometry. Plasma creatine kinase and muscle soreness were also assessed. These parameters were measured before and 1-8 days postexercise. The medial gastrocnemius exhibited significantly decreased FA 2-5 days after, increased λ(2) 3 days after, and increased λ(3) 2 and 3 days after exercise. This muscle also showed significantly increased MD and T(2) values 3 days postexercise. MVIP significantly decreased 2 and 3 days postexercise, while passive torque significantly increased 2 days postexercise. Creatine kinase and muscle soreness increased 3-5 days and 1-5 days postexercise, respectively. Exercise-induced muscle damage manifested as significant changes in muscle diffusion parameters with muscle-tendon complex dysfunction and delayed-onset muscle soreness. Copyright © 2011 Wiley-Liss, Inc.

  16. Individuals with chronic low back pain demonstrate delayed onset of the back muscle activity during prone hip extension.

    Science.gov (United States)

    Suehiro, Tadanobu; Mizutani, Masatoshi; Ishida, Hiroshi; Kobara, Kenichi; Osaka, Hiroshi; Watanabe, Susumu

    2015-08-01

    Prone hip extension (PHE) is commonly used in the evaluation of the stability of the lumbopelvic region. There is little evidence of difference in muscle activity onset timing between healthy individuals and individuals with chronic low back pain (CLBP) during PHE. The purpose of this study was to determine if individuals with and without CLBP differ in the onset time of the trunk and hip extensor muscles activity during PHE. The participants were 20 patients with CLBP and 20 healthy individuals. Electromyography data of the erector spinae, multifidus, gluteus maximus, and semitendinosus were collected during PHE using a surface electromyograph. Relative differences in the onset times between each muscle and the prime mover (i.e., the semitendinosus) were calculated. The onsets of the bilateral multifidus and contralateral erector spinae were significantly delayed in the CLBP group compared with the healthy group (pleg movement not being significantly different between the groups. The onset times of the gluteus maximus and ipsilateral erector spinae showed no significant differences between the groups. These results suggest that individuals with CLBP use an altered, and possibly inadequate, trunk muscle recruitment pattern.

  17. Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans

    Science.gov (United States)

    Nowotny, Bettina; Zahiragic, Lejla; Krog, Dorothea; Nowotny, Peter J.; Herder, Christian; Carstensen, Maren; Yoshimura, Toru; Szendroedi, Julia; Phielix, Esther; Schadewaldt, Peter; Schloot, Nanette C.; Shulman, Gerald I.; Roden, Michael

    2013-01-01

    Several mechanisms, such as innate immune responses via Toll-like receptor-4, accumulation of diacylglycerols (DAG)/ceramides, and activation of protein kinase C (PKC), are considered to underlie skeletal muscle insulin resistance. In this study, we examined initial events occurring during the onset of insulin resistance upon oral high-fat loading compared with lipid and low-dose endotoxin infusion. Sixteen lean insulin-sensitive volunteers received intravenous fat (iv fat), oral fat (po fat), intravenous endotoxin (lipopolysaccharide [LPS]), and intravenous glycerol as control. After 6 h, whole-body insulin sensitivity was reduced by iv fat, po fat, and LPS to 60, 67, and 48%, respectively (all P < 0.01), which was due to decreased nonoxidative glucose utilization, while hepatic insulin sensitivity was unaffected. Muscle PKCθ activation increased by 50% after iv and po fat, membrane Di-C18:2 DAG species doubled after iv fat and correlated with PKCθ activation after po fat, whereas ceramides were unchanged. Only after LPS, circulating inflammatory markers (tumor necrosis factor-α, interleukin-6, and interleukin-1 receptor antagonist), their mRNA expression in subcutaneous adipose tissue, and circulating cortisol were elevated. Po fat ingestion rapidly induces insulin resistance by reducing nonoxidative glucose disposal, which associates with PKCθ activation and a rise in distinct myocellular membrane DAG, while endotoxin-induced insulin resistance is exclusively associated with stimulation of inflammatory pathways. PMID:23454694

  18. Effect of vibration treatment on symptoms associated with eccentric exercise-induced muscle damage.

    Science.gov (United States)

    Lau, Wing Yin; Nosaka, Kazunori

    2011-08-01

    : The aim of this study was to test the hypothesis that vibration treatment reduces delayed-onset muscle soreness and swelling and enhances recovery of muscle function after eccentric exercise. : A randomized crossover design was used. Fifteen young men performed ten sets of six maximal eccentric contractions of the elbow flexors with the right arm for one occasion and the left arm for the other occasion separated by 4 wks. One arm received a 30-min vibration treatment at 30 mins after and 1, 2, 3, and 4 days after the exercise (treatment group), and the other arm did not receive any treatment (control group). The order of the treatment and control conditions and the use of the dominant and nondominant arms were counterbalanced among subjects. Changes in indirect markers of muscle damage were compared between arms by a two-way repeated-measures analysis of variance. : Compared with the control group, the treatment group showed significantly (P reduction in delayed-onset muscle soreness at 2 to 5 days after exercise. The recovery of range of motion was significantly (P control group. However, no significant effects on the recovery of muscle strength and serum creatine kinase activity were evident. Immediately after the vibration treatment, a significant (P motion were found. : These results showed that the vibration treatment was effective for attenuation of delayed-onset muscle soreness and recovery of range of motion after strenuous eccentric exercise but did not affect swelling, recovery of muscle strength, and serum creatine kinase activity.

  19. Skeletal muscle contractility, self-reported pain and tissue sensitivity in females with neck/shoulder pain and upper Trapezius myofascial trigger points - a randomized intervention study

    DEFF Research Database (Denmark)

    Myburgh, Corrie; Hartvigsen, Jan; Aagaard, Per

    2012-01-01

    -intervention and 48 hours post-intervention. Symptomatic and asymptomatic participant groups were each randomized into two treatment sub-groups (superficial (SDN) and deep dry needling (DDN)) after baseline testing. At 48 hours post-intervention participants were asked whether delayed onset muscle soreness (DOMS) and....../or post-needling soreness had developed. RESULTS: Muscle contractile characteristics did not differ between groups at baseline. Forty-six individuals developed muscle soreness (39 from mechanical testing and seven from needling). No inter-group differences were observed post-intervention for Fmax or RFD......The present investigation is one of the first to examine the hypothesis of gross muscle contractile inhibition due to the presence of diagnostically relevant MFTrPs.Individuals suffering from clinically relevant levels of self-reported pain are able to tolerate maximum voluntary contraction testing...

  20. Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy.

    Science.gov (United States)

    von Walden, Ferdinand; Casagrande, Vandre; Östlund Farrants, Ann-Kristin; Nader, Gustavo A

    2012-05-15

    The main goal of the present study was to investigate the regulation of ribosomal DNA (rDNA) gene transcription at the onset of skeletal muscle hypertrophy. Mice were subjected to functional overload of the plantaris by bilateral removal of the synergist muscles. Mechanical loading resulted in muscle hypertrophy with an increase in rRNA content. rDNA transcription, as determined by 45S pre-rRNA abundance, paralleled the increase in rRNA content and was consistent with the onset of the hypertrophic response. Increased transcription and protein expression of c-Myc and its downstream polymerase I (Pol I) regulon (POL1RB, TIF-1A, PAF53, TTF1, TAF1C) was also consistent with the increase in rRNA. Similarly, factors involved in rDNA transcription, such as the upstream binding factor and the Williams syndrome transcription factor, were induced by mechanical loading in a corresponding temporal fashion. Chromatin immunoprecipitation revealed that these factors, together with Pol I, were enriched at the rDNA promoter. This, in addition to an increase in histone H3 lysine 9 acetylation, demonstrates that mechanical loading regulates rRNA synthesis by inducing a gene expression program consisting of a Pol I regulon, together with accessory factors involved in transcription and chromatin remodeling at the rDNA promoter. Altogether, these data indicate that transcriptional and epigenetic mechanisms take place in the regulation of ribosome production at the onset of muscle hypertrophy.

  1. Development of the research on delayed onset muscle soreness%延迟性肌肉疼痛防治的研究进展

    Institute of Scientific and Technical Information of China (English)

    庄冲

    2005-01-01

    延迟性肌肉疼痛是运动员从事不习惯的运动后所经历的一种肌肉疼痛或不适的感觉,能够导致运动能力的下降,其产生机制目前尚不清楚.有多种手段和方法来防治延迟性肌肉疼痛,但结果不一,运动以及中医药在减轻症状方面效果明显.

  2. Discussion of Microanatomy on Delayed-Onset Muscle Soreness in Sports%运动性肌肉延迟性疼痛的组织学探讨

    Institute of Scientific and Technical Information of China (English)

    徐世军; 黄宗峰; 莫伟彬

    2008-01-01

    运动性肌肉延迟性疼痛是一个全身多个系统,多个层次综合作用的结果.本文在组织学基础上提出影响肌肉延迟性疼痛的可能性机制,其目的是为运动性肌肉延迟性疼痛的研究从组织学方面提供理论依据.

  3. Research Progress of Delayed-Onset Muscle Soreness%延迟性肌肉酸痛的研究进展

    Institute of Scientific and Technical Information of China (English)

    张海平; 刘建军; 董敏辉

    2007-01-01

    机体大强度或不习惯的运动,尤其是离心运动,常常会引起肌肉的延迟性酸痛,并在运动后的2~3天达到高峰,伴有一系列的肌肉结构、组织学及生物化学的改变,严重时会影响到人们体育健身及运动训练的效果.有关延迟性肌肉酸痛的研究已有百年的历史,但其产生的病因、机制等至今仍不完全清楚,也没有找到真正有效地清除或减轻肌肉酸痛的方法.通过对国内外相关文献的归纳、分析和综合,对运动性延迟性疼痛的产生机制及防治进展等进行广泛探讨,为体育健身和运动训练提供理论依据.

  4. Discussion on the Deiayed-onset Muscle Soreness Caused by Exercises%运动导致延迟性肌肉酸痛探微

    Institute of Scientific and Technical Information of China (English)

    吴忠义; 梁家劭

    2001-01-01

    人体从事大强度或不习惯运动后产生的延迟性肌内酸痛,长期以来困扰着运动训练和大众体育健身活动的顺利进行.本文从运动生理学的视角,对产生延迟性肌肉酸痛的原因进行了探讨;提出了预防与消除延迟性肌肉酸痛的手段.旨在为运动训练和全民体育健身活动提供一点借鉴.

  5. Mechanism and theory of delayed onset muscle soreness%延迟性肌肉酸痛的机制及其理论研究

    Institute of Scientific and Technical Information of China (English)

    张双燕; 张翔; 任秀红

    2009-01-01

    延迟性肌肉酸痛妨碍了大部分运动员或普通人运动能力的发挥,因此探讨延迟性肌肉酸痛的产生机制对于预防或治疗延迟性肌肉酸痛有着举足轻重的作用.但诱发延迟性肌肉酸痛的内在机制尚未完全清晰.新近的一些研究成果表明延迟性肌肉酸痛可能与肌节重塑过程、微循环紊乱和外周神经系统的变化有关.文章就形成延迟性肌肉酸痛的机制学说进行述评,并试图依据此提出相应治疗原则.

  6. 延迟性肌肉疼痛的研究现状%On the Present Research Situation of Delayed-Onset Muscle Soreness

    Institute of Scientific and Technical Information of China (English)

    岳冠华

    2005-01-01

    论述了延迟性肌肉疼痛的概念、与运动的关系,及其发生机理、防治方法的研究现状,进一步探讨了延迟性肌肉疼痛的适应性、离心收缩力量练习在延迟性肌肉疼痛中的特异性作用.

  7. Adding Fish Oil to Whey Protein, Leucine and Carbohydrate Over a 6 Week Supplementation Period Attenuates Muscle Soreness Following Eccentric Exercise in Competitive Soccer Players.

    Science.gov (United States)

    Philpott, Jordan D; Donnelly, Chris; Walshe, Ian H; Dick, James; Galloway, Stuart D R; Tipton, Kevin D; Witard, Oliver C

    2017-09-05

    Soccer players often experience eccentric exercise-induced muscle damage given the physical demands of soccer match-play. Since long chain n-3 polyunsaturated fatty acids (n-3PUFA) enhance muscle sensitivity to protein supplementation, dietary supplementation with a combination of fish oil-derived n-3PUFA, protein and carbohydrate may promote exercise recovery. This study examined the influence of adding n-3PUFA to a whey protein, leucine and carbohydrate containing beverage over a 6 week supplementation period on physiological markers of recovery measured over 3 days following eccentric exercise. Competitive soccer players were assigned to one of three conditions (2 × 200mL): FO (n=10) contained n-3PUFA (1100mg DHA/EPA - approx. 550mg DHA, 550mg EPA), whey protein (15g), leucine (1.8g) and carbohydrate (20g); PRO (n=10) contained whey protein (15g), leucine (1.8g) and carbohydrate (20g) and CHO (n=10) contained carbohydrate (24g). Eccentric exercise consisted of unilateral knee extension/flexion contractions on both legs separately. Maximal force production was impaired by 22% during the 72 hour recovery period following eccentric exercise (peccentric exercise in competitive soccer players.

  8. Manual muscle test at C5 palsy onset predicts the likelihood of and time to C5 palsy resolution.

    Science.gov (United States)

    Macki, Mohamed; Alam, Ridwan; Kerezoudis, Panagiotis; Gokaslan, Ziya; Bydon, Ali; Bydon, Mohamad

    2016-02-01

    The primary objective of this study was to identify time to and prognostic factors of C5 palsy resolution. All patients over a 7 year period who experienced C5 palsy following a posterior decompression and instrumented fusion surgery were retrospectively reviewed. C5 palsy resolution was defined as a recovery of deltoid muscle function equal to or greater than the preoperative condition as defined by the manual muscle test (MMT). Of the 511 patients who met the selection criteria, 8.6% (n=44) experienced C5 palsy. MMT information was available for 43 patients; 81.4% (n=35) had full resolution from their condition. Of the 35 patients who resolved, the median MMT score at onset was 3-. Following a discrete-time proportional hazards model, the hazards of C5 palsy resolution increased by 19% for every one-grade increase in MMT score at symptom onset (hazard ratio [HR]=1.19, p=0.005). Moreover, males displayed a 71% lower hazard of resolution than females (HR=0.29, p=0.003). Following an adjusted Kaplan-Meier analysis, the median time to C5 palsy resolution was between 6 months and 1 year. In a multiple linear regression, a lower MMT score at the onset of C5 palsy predicted a longer time to C5 palsy resolution (coefficient=-0.19, p=0.003). Time to C5 palsy onset was not statistically associated with hazards of palsy resolution (p=0.381) or time to resolution (p=0.121). A higher MMT score at the onset of C5 palsy statistically significantly predicted a higher chance of resolution and a shorter recovery time. Female sex was also associated with a higher hazard of resolution.

  9. Skeletal Muscle Magnetic Resonance Imaging of the Lower Limbs in Late-onset Lipid Storage Myopathy with Electron Transfer Flavoprotein Dehydrogenase Gene Mutations

    Institute of Scientific and Technical Information of China (English)

    Xin-Yi Liu; Ming Jin; Zhi-Qiang Wang; Dan-Ni Wang; Jun-Jie He; Min-Ting Lin; Hong-Xia Fu

    2016-01-01

    Background:Lipid storage myopathy (LSM) is a genetically heterogeneous group with variable clinical phenotypes.Late-onset multiple acyl-coenzyme A dehydrogenation deficiency (MADD) is a rather common form of LSM in China.Diagnosis and clinical management of it remain challenging,especially without robust muscle biopsy result and genetic detection.As the noninvasion and convenience,muscle magnetic resonance imaging (MRI) is a helpful assistant,diagnostic tool for neuromuscular disorders.However,the disease-specific MRI patterns of muscle involved and its diagnostic value in late-onset MADD have not been systematic analyzed.Methods:We assessed the MRI pattern and fat infiltration degree of the lower limb muscles in 28 late-onset MADD patients,combined with detailed clinical features and gene spectrum.Fat infiltration degree of the thigh muscle was scored while that ofgluteus was described as obvious or not.Associated muscular atrophy was defined as obvious muscle bulk reduction.Results:The mean scores were significantly different among the anterior,medial,and posterior thigh muscle groups.The mean of fat infiltration scores on posterior thigh muscle group was significantly higher than either anterior or medial thigh muscle group (P < 0.001).Moreover,the mean score on medial thigh muscle group was significantly higher than that of anterior thigh muscle group (P < 0.01).About half of the patients displayed fat infiltration and atrophy in gluteus muscles.Of 28 patients,12 exhibited atrophy in medial and/or posterior thigh muscle groups,especially in posterior thigh muscle group.Muscle edema pattern was not found in all the patients.Conclusions:Late-onset MADD patients show a typical muscular imaging pattern of fat infiltration and atrophy on anterior,posterior,and medial thigh muscle groups,with major involvement of posterior thigh muscle group and gluteus muscles and a sparing involvement of anterior thigh compartment.Our findings also suggest that muscle MRI of

  10. Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise.

    Science.gov (United States)

    Talanian, Jason L; Tunstall, Rebecca J; Watt, Matthew J; Duong, Mylinh; Perry, Christopher G R; Steinberg, Gregory R; Kemp, Bruce E; Heigenhauser, George J F; Spriet, Lawrence L

    2006-10-01

    Skeletal muscle hormone-sensitive lipase (HSL) activity is increased by contractions and increases in blood epinephrine (EPI) concentrations and cyclic AMP activation of the adrenergic pathway during prolonged exercise. To determine the importance of hormonal stimulation of HSL activity during the onset of moderate- and high-intensity exercise, nine men [age 24.3 +/- 1.2 yr, 80.8 +/- 5.0 kg, peak oxygen consumption (VO2 peak) 43.9 +/- 3.6 ml x kg(-1) x min(-1)] cycled for 1 min at approximately 65% VO2 peak, rested for 60 min, and cycled at approximately 90% VO2 peak for 1 min. Skeletal muscle biopsies were taken pre- and postexercise, and arterial blood was sampled throughout exercise. Arterial EPI increased (P HSL activity increased (P HSL Ser660 phosphorylation (approximately 55% increase) and ERK1/2 phosphorylation ( approximately 33% increase) were augmented following exercise at both intensities, whereas HSL Ser563 and Ser565 phosphorylation were not different from rest. The results indicate that increases in arterial EPI concentration during the onset of moderate- and high-intensity exercise increase cyclic AMP content, which results in the phosphorylation of HSL Ser660. This adrenergic stimulation contributes to the increase in HSL activity that occurs in human skeletal muscle in the first minute of exercise at 65% and 90% VO2 peak.

  11. Early-onset acquired myasthenia gravis secondary to anti-muscle-specific kinase autoantibodies.

    Science.gov (United States)

    Yilmaz, Sanem; Gokben, Sarenur; Serdaroglu, Gul; Akcay, Ayfer

    2014-01-01

    Autoimmune myasthenia gravis is rarely seen during infancy. Similar to adults, 85% to 90% of generalized pediatric myasthenia gravis cases have acetylcholine receptor antibodies. Approximately 30% of the remaining cases have antibodies against muscle-specific kinase. Information on the clinical course, treatment alternatives, and prognosis of pediatric muscle-specific kinase antibody-positive myasthenia gravis is limited because of the small number of cases. Here, we present a 14-month-old girl with muscle-specific kinase antibody-positive myasthenia gravis as one of the youngest patients described so far in the literature.

  12. Frequency of anticipatory trunk muscle onsets in children with and without developmental coordination disorder.

    Science.gov (United States)

    Kane, Kyra; Barden, John

    2014-02-01

    This study used electromyography to compare the frequency of anticipatory postural adjustments for three bilateral trunk muscles and unilateral tibialis anterior muscle between children with and without developmental coordination disorder (DCD; n = 22, ages 7 to 14 years) during three tasks (kicking a ball, stepping onto a step, standing on one foot). Between-group comparisons demonstrated significantly less frequent anticipatory activation of ipsilateral tibialis anterior, ipsilateral transversus abdominis/internal oblique, and bilateral external oblique muscles in children with DCD. Odds ratios indicated that children with DCD utilized anticipatory contractions of these muscles one half to one quarter as often as the typically developing children did, while performing the same tasks. These results suggest that the movement difficulties experienced by children with DCD may be associated with less frequent anticipatory adjustments. For these children, inconsistent preparatory activation may contribute to postural control difficulties, excessive movement variability and poor movement quality.

  13. Soreness-related changes in three-dimensional running biomechanics following eccentric knee extensor exercise.

    Science.gov (United States)

    Paquette, Max R; Peel, Shelby A; Schilling, Brian K; Melcher, Dan A; Bloomer, Richard J

    2017-06-01

    Runners often experience delayed onset muscle soreness (DOMS), especially of the knee extensors, following prolonged running. Sagittal knee joint biomechanics are altered in the presence of knee extensor DOMS but it is unclear how muscle soreness affects lower limb biomechanics in other planes of motion. The purpose of this study was to assess the effects of knee extensor DOMS on three-dimensional (3D) lower limb biomechanics during running. Thirty-three healthy men (25.8 ± 6.8 years; 84.1 ± 9.2 kg; 1.77 ± 0.07 m) completed an isolated eccentric knee extensor damaging protocol to elicit DOMS. Biomechanics of over-ground running at a set speed of 3.35 m s(-1)±5% were measured before eccentric exercise (baseline) and, 24 h and 48 h following exercise in the presence of knee extensor DOMS. Knee flexion ROM was reduced at 48 h (P = 0.01; d = 0.26), and peak knee extensor moment was reduced at 24 h (P = 0.001; d = 0.49) and 48 h (P biomechanics were unaffected by the presence of DOMS (P > 0.05). Peak positive ankle and knee joint powers and, peak negative knee joint power were all reduced from baseline to 24 h and 48 h (P biomechanics during running.

  14. Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat.

    Science.gov (United States)

    Alvarez, Pedro; Bogen, Oliver; Green, Paul G; Levine, Jon D

    2017-08-01

    Delayed-onset muscle soreness is typically observed after strenuous or unaccustomed eccentric exercise. Soon after recovery, blunted muscle soreness is observed on repeated eccentric exercise, a phenomenon known as repeated bout effect (RBE). Although regular physical activity decreases muscle hyperalgesia, likely because of increased production of the anti-inflammatory cytokine interleukin-10 (IL-10) in the skeletal muscle, whether IL-10 also contributes to the antinociceptive effect of RBE is unknown. Furthermore, whether IL-10 attenuates muscle hyperalgesia by acting on muscle nociceptors remains to be established. Here, we explored the hypothesis that blunted muscle nociception observed in RBE depends on a local effect of IL-10, acting on IL-10 receptor 1 (IL-10R1) expressed by muscle nociceptors. Results show that after a second bout of eccentric exercise, rats exhibited decreased muscle hyperalgesia, indicative of RBE, and increased expression of IL-10 in the exercised gastrocnemius muscle. Although knockdown of IL-10R1 protein in nociceptors innervating the gastrocnemius muscle by intrathecal antisense oligodeoxynucleotide did not change nociceptive threshold in naive rats, it unveiled latent muscle hyperalgesia in rats submitted to eccentric exercise 12 days ago. Furthermore, antisense also prevented the reduction of muscle hyperalgesia observed after a second bout of eccentric exercise. These data indicate that recovery of nociceptive threshold after eccentric exercise and RBE-induced analgesia depend on a local effect of IL-10, acting on its canonical receptor in muscle nociceptors.

  15. Muscle strength as a predictor of onset of ADL dependence in people aged 75 years

    DEFF Research Database (Denmark)

    Rantanen, Taina; Avlund, Kirsten; Suominen, Harri

    2002-01-01

    The aim of this prospective study over 5 years was to examine maximal isometric strength of multiple muscle groups as a predictor of losing independence in activities of daily living (ADL). The participants were from the Nordic Research on Aging (NORA75). These analyses are restricted to 567 people....... Of the 227 initially ADL independent men, 21 (9.3%) became dependent in ADL. In women, the figures were 30 (8.8%) of 340. Multiple logistic regression models were used to predict the risk of ADL dependence in groups based on strength tertiles. After confirming that the association of muscle strength...... dependent because of poor muscle strength, and who could reduce their risk by strengthening exercises....

  16. Myofibre damage in human skeletal muscle

    DEFF Research Database (Denmark)

    Crameri, R M; Aagaard, P; Qvortrup, K

    2007-01-01

    Disruption to proteins within the myofibre after a single bout of unaccustomed eccentric exercise is hypothesized to induce delayed onset of muscle soreness and to be associated with an activation of satellite cells. This has been shown in animal models using electrical stimulation but not in hum......Disruption to proteins within the myofibre after a single bout of unaccustomed eccentric exercise is hypothesized to induce delayed onset of muscle soreness and to be associated with an activation of satellite cells. This has been shown in animal models using electrical stimulation...... but not in humans using voluntary exercise. Untrained males (n=8, range 22-27 years) performed 210 maximal eccentric contractions with each leg on an isokinetic dynamometer, voluntarily (VOL) with one leg and electrically induced (ES) with the other leg. Assessments from the skeletal muscle were obtained prior...... to exercise and at 5, 24, 96 and 192 h postexercise. Muscle tenderness rose in VOL and ES after 24 h, and did not differ between groups. Maximal isometric contraction strength, rate of force development and impulse declined in the VOL leg from 4 h after exercise, but not in ES (except at 24 h). In contrast...

  17. A new flap alternative for trochanteric pressure sore coverage: distal gluteus maximus musculocutaneous advancement flap.

    Science.gov (United States)

    Nisanci, Mustafa; Sahin, Ismail; Eski, Muhitdin; Alhan, Dogan

    2015-02-01

    Management of long-term bedridden patients experiencing pressure sores still represents a surgical challenge due to limited flap alternatives and high recurrence rates after the treatment. Fasciocutaneous, musculocutaneous, local perforator-based flaps, and free flaps have all been used for treatment of trochanteric pressure sores. This study presents a new use of distal gluteus maximus (GM) muscle as an advancement musculocutaneous flap for coverage of trochanteric pressure sores in 7 patients. The technique involves design of a long V-shaped skin island over the distal fibers of the GM muscle, beginning from the inferoposterior wound edge and extending inferomedially, almost parallel to the gluteal crease. After its harvest as an island flap on the distal fibers of the GM muscle, the skin paddle can be advanced onto the trochanteric defect, whereas the muscle itself is rotated after severing its insertion to femur. If a second triangular skin island is designed on the proximal fibers of GM muscle to cover an associated sacral defect, 2 coexisting pressure sores can be reconstructed concomitantly with 2 skin paddles on a single muscle belly at 1 surgical setting. Of the 7 patients, 3 had 3 (bilateral trochanteric and sacral), 2 had 2 (sacral and trochanteric), and 2 had 1 (only trochanteric) pressure sores. All ulcers were closed successfully and all of the flaps survived totally without any complication except the one in which we experienced minimal wound dehiscence in the early postoperative period. Conclusively, our current surgical method provided a reliable coverage for trochanteric pressure sores although it was technically straightforward and fast. Additionally, it offers simultaneous closure of 2 pressure ulcers with 2 skin islands on a single muscle flap.

  18. Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet.

    Science.gov (United States)

    Rocchi, Anna; Milioto, Carmelo; Parodi, Sara; Armirotti, Andrea; Borgia, Doriana; Pellegrini, Matteo; Urciuolo, Anna; Molon, Sibilla; Morbidoni, Valeria; Marabita, Manuela; Romanello, Vanina; Gatto, Pamela; Blaauw, Bert; Bonaldo, Paolo; Sambataro, Fabio; Robins, Diane M; Lieberman, Andrew P; Sorarù, Gianni; Vergani, Lodovica; Sandri, Marco; Pennuto, Maria

    2016-07-01

    Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA knock-in mice and patients. We show that glycolytic muscles were more severely affected than oxidative muscles in SBMA knock-in mice. Muscle atrophy was associated with early-onset, progressive glycolytic-to-oxidative fiber-type switch. Whole genome microarray and untargeted lipidomic analyses revealed enhanced lipid metabolism and impaired glycolysis selectively in muscle. These metabolic changes occurred before denervation and were associated with a concurrent enhancement of mechanistic target of rapamycin (mTOR) signaling, which induced peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC1α) expression. At later stages of disease, we detected mitochondrial membrane depolarization, enhanced transcription factor EB (TFEB) expression and autophagy, and mTOR-induced protein synthesis. Several of these abnormalities were detected in the muscle of SBMA patients. Feeding knock-in mice a high-fat diet (HFD) restored mTOR activation, decreased the expression of PGC1α, TFEB, and genes involved in oxidative metabolism, reduced mitochondrial abnormalities, ameliorated muscle pathology, and extended survival. These findings show early-onset and intrinsic metabolic alterations in SBMA muscle and link lipid/glucose metabolism to pathogenesis. Moreover, our results highlight an HFD regime as a promising approach to support SBMA patients.

  19. Effects of cold water immersion on the recovery of physical performance and muscle damage following a one-off soccer match.

    Science.gov (United States)

    Ascensão, António; Leite, Marco; Rebelo, António N; Magalhäes, Sérgio; Magalhäes, José

    2011-02-01

    The aim of this study was to assess the effects of a single session of cold or thermoneutral water immersion after a one-off match on muscular dysfunction and damage in soccer players. Twenty-male soccer players completed one match and were randomly divided into cryotherapy (10 min cold water immersion, 10°C, n = 10) and thermoneutral (10 min thermoneutral water immersion, 35°C, n = 10) groups. Muscle damage (creatine kinase, myoglobin), inflammation (C-reactive protein), neuromuscular function (jump and sprint abilities and maximal isometric quadriceps strength), and delayed-onset muscle soreness were evaluated before, within 30 min of the end, and 24 and 48 h after the match. After the match, the players in both groups showed increased plasma creatine kinase activity (30 min, 24 h, 48 h), myoglobin (30 min) and C-reactive protein (30 min, 24 h) concentrations. Peak jump ability and maximal strength were decreased and delayed-onset muscle soreness increased in both groups. However, differential alterations were observed between thermoneutral water and cold water immersion groups in creatine kinase (30 min, 24 h, 48 h), myoglobin (30 min), C-reactive protein (30 min, 24 h, 48 h), quadriceps strength (24 h), and quadriceps (24 h), calf (24 h) and adductor (30 min) delayed-onset muscle soreness. The results suggest that cold water immersion immediately after a one-off soccer match reduces muscle damage and discomfort, possibly contributing to a faster recovery of neuromuscular function.

  20. Adult onset flatfoot associated with an intramuscular hemangioma of the posterior tibialis muscle.

    Science.gov (United States)

    Kryzak, Thomas John; DeGroot, Henry

    2008-03-01

    A 30-year-old man was referred for a painful mass in the left calf and planovalgus deformity of the left foot. The pain had been present for 15 years but recently had become severe. On examination there was a visible, exquisitely tender mass in the medial distal aspect of the lower leg. There was valgus deformity of the hindfoot, abduction of the forefoot, and complete loss of the longitudinal arch which was passively correctable to neutral. Magnetic resonance imaging showed a 3.035.5312.0-cm complex mass in the calf with a "bag of worms" appearance consistent with a vascular tumor. An incisional biopsy resulted in diagnosis of benign intermuscular hemangioma. A marginal resection of the mass was later performed. During operative resection, the tumor was found to involve the entire posterior tibialis muscle to the musculotendinous junction. The patient began full weight bearing 4 weeks postoperatively and was placed in an ankle-foot orthosis for correction of the planovalgus. At 19 months postoperative, he reported no pain and mild weakness of the left foot, and he had returned to full-time work. There was no recurrence of the tumor. Intermuscular hemangioma of the calf may cause acquired spasticity and equinus deformity of the foot. In addition, intramuscular hemangiomas have been reported to cause muscle weakness and tendon rupture. In this patient, the authors believe that the posterior tibialis muscle was weakened and elongated secondary to the replacement of the muscle tissue by the tumor, ultimately leading to the planovalgus deformity.

  1. Differential α-adrenergic modulation of rapid onset vasodilatation along resistance networks of skeletal muscle in old versus young mice.

    Science.gov (United States)

    Sinkler, Shenghua Y; Fernando, Charmain A; Segal, Steven S

    2016-12-01

    Rapid onset vasodilatation (ROV) initiates functional hyperaemia upon skeletal muscle contraction and is attenuated during ageing via α-adrenoreceptor (αAR) stimulation, but it is unknown where this effect predominates in resistance networks. In gluteus maximus muscles of young (4 months) and old (24 months) male C57BL/6 mice, tetanic contraction while observing feed arteries and arterioles initiated ROV, which increased with contraction duration, peaked later in upstream versus downstream vessel branches and was attenuated throughout networks with advanced age. With no effect on muscle force production, inhibiting αARs improved ROV in old mice while activating αARs attenuated ROV in young mice. Modulating ROV through αARs was greater in upstream feed arteries and arterioles compared to downstream arterioles, with α2 ARs more effective than α1 ARs. ROV is coordinated along resistance networks and modulated differentially between young and old mice via αARs; with advanced age, attenuated dilatation of upstream branches will restrict muscle blood flow. Rapid onset vasodilatation (ROV) in skeletal muscle is attenuated during advanced age via α-adrenoreceptor (αAR) activation, but it is unknown where such effects predominate in the resistance vasculature. Studying the gluteus maximus muscle (GM) of anaesthetized young (4 months) and old (24 months) male C57BL/6 mice, we tested the hypothesis that attenuation of ROV during advanced age is most effective in proximal branches of microvascular resistance networks. Diameters of a feed artery (FA) and first- (1A), second- (2A) and third- (3A) order arterioles were studied in response to single tetanic contractions (100 Hz, 100-1000 ms). ROV began within 1 s and peaked sooner in 2A and 3A (∼3 s) than in 1A or FA (∼4 s). Relative amplitudes of dilatation increased with contraction duration and with vessel branch order (FAROV was greater in FA and 1A compared to 2A and 3A. With no effect on muscle force

  2. Comparison of Muscle Onset Activation Sequences between a Golf or Tennis Swing and Common Training Exercises Using Surface Electromyography: A Pilot Study

    Directory of Open Access Journals (Sweden)

    John M. Vasudevan

    2016-01-01

    Full Text Available Aim. The purpose of this pilot study is to use surface electromyography to determine an individual athlete’s typical muscle onset activation sequence when performing a golf or tennis forward swing and to use the method to assess to what degree the sequence is reproduced with common conditioning exercises and a machine designed for this purpose. Methods. Data for 18 healthy male subjects were collected for 15 muscles of the trunk and lower extremities. Data were filtered and processed to determine the average onset of muscle activation for each motion. A Spearman correlation estimated congruence of activation order between the swing and each exercise. Correlations of each group were pooled with 95% confidence intervals using a random effects meta-analytic strategy. Results. The averaged sequences differed among each athlete tested, but pooled correlations demonstrated a positive association between each exercise and the participants’ natural muscle onset activation sequence. Conclusion. The selected training exercises and Turning Point™ device all partially reproduced our athletes’ averaged muscle onset activation sequences for both sports. The results support consideration of a larger, adequately powered study using this method to quantify to what degree each of the selected exercises is appropriate for use in both golf and tennis.

  3. Comparison of Muscle Onset Activation Sequences between a Golf or Tennis Swing and Common Training Exercises Using Surface Electromyography: A Pilot Study.

    Science.gov (United States)

    Vasudevan, John M; Logan, Andrew; Shultz, Rebecca; Koval, Jeffrey J; Roh, Eugene Y; Fredericson, Michael

    2016-01-01

    Aim. The purpose of this pilot study is to use surface electromyography to determine an individual athlete's typical muscle onset activation sequence when performing a golf or tennis forward swing and to use the method to assess to what degree the sequence is reproduced with common conditioning exercises and a machine designed for this purpose. Methods. Data for 18 healthy male subjects were collected for 15 muscles of the trunk and lower extremities. Data were filtered and processed to determine the average onset of muscle activation for each motion. A Spearman correlation estimated congruence of activation order between the swing and each exercise. Correlations of each group were pooled with 95% confidence intervals using a random effects meta-analytic strategy. Results. The averaged sequences differed among each athlete tested, but pooled correlations demonstrated a positive association between each exercise and the participants' natural muscle onset activation sequence. Conclusion. The selected training exercises and Turning Point™ device all partially reproduced our athletes' averaged muscle onset activation sequences for both sports. The results support consideration of a larger, adequately powered study using this method to quantify to what degree each of the selected exercises is appropriate for use in both golf and tennis.

  4. A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles.

    Science.gov (United States)

    Fujii, Takayuki; Hayashi, Shintaro; Kawamura, Nobutoshi; Higuchi, Masa-Aki; Tsugawa, Jun; Ohyagi, Yasumasa; Hayashi, Yukiko K; Nishino, Ichizo; Kira, Jun-Ichi

    2014-08-15

    We herein report a 32-year-old woman with adult-onset reducing body myopathy (RBM) who had a mutation in the four-and-a-half LIM domain 1 gene (FHL1) and showed a marked asymmetrical involvement of sternocleidomastoid and trapezius muscles. At 30 years of age she noticed bilateral foot drop, and over the next two years developed difficulty raising her right arm. At 32 years of age she was admitted to our hospital for a diagnostic evaluation. Neurological examination showed moderate weakness and atrophy of her right sternocleidomastoid muscle, right trapezius muscle, and bilateral upper proximal muscles. There were severe weakness and atrophy of her bilateral tibialis anterior muscles. Her deep tendon reflexes were hypoactive in her upper extremities. Her serum creatine kinase level was mildly increased. Muscle biopsy specimens from the left tibialis anterior muscle revealed marked variation in fiber size, some necrotic or regenerating fibers, and reducing bodies. Gene analysis of FHL1 demonstrated a mutation: a heterozygous missense mutation of c.377G>A (p. C126T) in FHL1. Compared with previous adult-onset RBM cases harboring mutations in FHL1, our case was characterized by asymmetrical atrophy of the sternocleidomastoid and trapezius muscles. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. An elderly-onset limb girdle muscular dystrophy type 1B (LGMD1B) with pseudo-hypertrophy of paraspinal muscles.

    Science.gov (United States)

    Furuta, Mitsuru; Sumi-Akamaru, Hisae; Takahashi, Masanori P; Hayashi, Yukiko K; Nishino, Ichizo; Mochizuki, Hideki

    2016-09-01

    Mutations in LMNA, encoding A-type lamins, lead to diverse disorders, collectively called "laminopathies," which affect the striated muscle, cardiac muscle, adipose tissue, skin, peripheral nerve, and premature aging. We describe a patient with limb-girdle muscular dystrophy type 1B (LGMD1B) carrying a heterozygous p.Arg377His mutation in LMNA, in whom skeletal muscle symptom onset was at the age of 65 years. Her weakness started at the erector spinae muscles, which showed marked pseudo-hypertrophy even at the age of 72 years. Her first episode of syncope was at 44 years; however, aberrant cardiac conduction was not revealed until 60 years. The p.Arg377His mutation has been previously reported in several familial LMNA-associated myopathies, most of which showed muscle weakness before the 6th decade. This is the first report of pseudo-hypertrophy of paravertebral muscles in LMNA-associated myopathies. The pseudo-hypertrophy of paravertebral muscles and the elderly-onset of muscle weakness make this case unique and reportable.

  6. Effects of prior contractions on muscle microvascular oxygen pressure at onset of subsequent contractions

    Science.gov (United States)

    Behnke, Brad J; Kindig, Casey A; Musch, Timothy I; Sexton, William L; Poole, David C

    2002-01-01

    In humans, pulmonary oxygen uptake (V̇O2) kinetics may be speeded by prior exercise in the heavy domain. This ‘speeding’ arises potentially as the result of an increased muscle O2 delivery (Q̇O2) and/or a more rapid elevation of oxidative phosphorylation. We adapted phosphorescence quenching techniques to determine the QO2-to-O2 utilization (Q̇O2/V̇O2) characteristics via microvascular O2 pressure (PO2,m) measurements across sequential bouts of contractions in rat spinotrapezius muscle. Spinotrapezius muscles from female Sprague-Dawley rats (n = 6) were electrically stimulated (1 Hz twitch, 3–5 V) for two 3 min bouts (ST1 and ST2) separated by 10 min rest. PO2,m responses were analysed using an exponential + time delay (TD) model. There was no significant difference in baseline and ΔPO2,m between ST1 and ST2 (28.5 ± 2.6 vs. 27.9 ± 2.4 mmHg, and 13.9 ± 1.8 vs. 14.1 ± 1.3 mmHg, respectively). The TD was reduced significantly in the second contraction bout (ST1, 12.2 ± 1.9; ST2, 5.7 ± 2.2 s, P 0.1). The shortened TD found in ST2 led to a reduced time to reach 63 % of the final response of ST2 compared to ST1 (ST1, 28.3 ± 3.0; ST2, 20.2 ± 1.8 s, P < 0.05). The speeding of the overall response in the absence of an elevated PO2,m baseline (which had it occurred would indicate an elevated QO2/V̇O2) or muscle blood flow suggests that some intracellular process(es) (e.g. more rapid increase in oxidative phosphorylation) may be responsible for the increased speed of PO2,m kinetics after prior contractions under these conditions. PMID:11897861

  7. Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series.

    Science.gov (United States)

    Furby, A; Béhin, A; Lefaucheur, J-P; Beauvais, K; Marcorelles, P; Mussini, J-M; Bassez, G; Créange, A; Eymard, B; Pénisson-Besnier, I

    2010-01-01

    Patients with cervical or mediastinal Hodgkin disease (HD) classically underwent chemotherapy plus extended-field radiation therapy. We report six patients who gradually developed severe atrophy and weakness of cervical paraspinal and shoulder girdle muscles 5-30 years after mantle irradiation for HD. Although clinical presentation was uniform, including a dropped head syndrome, electrophysiological and pathological findings were rather heterogeneous. Either neurogenic or myogenic processes may be involved and sometimes combined. We discuss the pathophysiological mechanisms underlying these cervicoscapular motor complications of mantle irradiation in HD.

  8. NO及NOS在老年Ⅰ期压疮大鼠骨骼肌组织细胞凋亡中的作用%Effect of NO/NOS on apoptosis of skeletal muscle tissue cells in elderly rats with pressure sore in phase Ⅰ

    Institute of Scientific and Technical Information of China (English)

    王艳; 周守凤; 高金华; 陈慧敏; 郑国荣; 刁波

    2013-01-01

    Objective To observe the effect of NO and NOS during the process of cell apoptosis in elderly rats with pressure sore (phase Ⅰ),and to further investigate the mechanism of pressure sore.Methods A total of 12 rats were divided into model group (6 rats) and control group (6 rats).A pressure of 22.47kPa was pushed on model group while no pressure on control group,and two groups of rats were put to death with euthanasia after 2 h.Finally,the pathological changes of the skin and muscle were observed under light microscope,and the levels and activity of NO,NOS and SOD,and the apoptosis index (AI) were detected.Results In model group,the stratified squamous epithelium cells showed thin,and the structure became unclear,vacuolar alteration in muscle fibers,mild edema,waxy degeneration,muscle tissue atrophy and autolysis,while the color and structure of skin and muscle were normal in control group.There were significant differences between the two groups in the levels and activity of NO,NOS and SOD.NO,NOS were positively correlated with the process of cell AI.Conclusions NO and NOS play a key mediated role in the process of skin and muscle cell apoptosis in elderly rat with pressure sore (phase I).The lipid peroxidation and apoptosis induced by NO may be one of the potential mechanisms in the formation of early pressure sore.%目的 观察一氧化氮(N0)及一氧化氮合酶(NOS)在老年Ⅰ期压疮大鼠骨骼肌组织细胞凋亡中的作用,进一步探索老年压疮发生机制. 方法 将老年SD大鼠12只随机分成对照组和模型组,各6只.对照组不受压、模型组承受22.47 kPa压强2h后2组大鼠一起实施安乐死.实验终点,光镜观察皮肤肌肉组织病理学变化;检测肌组织中NO、NOS和超氧化物歧化酶(SOD)的活性和含量;检测皮肤和肌肉组织中细胞凋亡指数(AI)的变化. 结果 对照组镜下观察皮肤完整,颜色、结构正常;模型组大鼠复层鳞状上皮较薄,结构层次欠清晰.肌纤维

  9. Poor muscle strength and function in physically inactive childhood-onset systemic lupus erythematosus despite very mild disease

    Directory of Open Access Journals (Sweden)

    Ana Jéssica Pinto

    Full Text Available ABSTRACT Objective: To compare muscle strength (i.e. lower- and upper-body strength and function between physically inactive childhood-onset systemic lupus erythematosus patients (C-SLE and healthy controls (CTRL. Methods: This was a cross-sectional study and the sample consisted of 19 C-SLE (age between 9 and 18 years and 15 CTRL matched by age, sex, body mass index (BMI, and physical activity levels (assessed by accelerometry. Lower- and upper-body strength was assessed by the one-repetition-maximum (1-RM test. Isometric strength was assessed through a handgrip dynamometer. Muscle function was evaluated by the timed-stands test (TST and the timed-up-and-go test (TUG. Results: When compared with CTRL, C-SLE showed lower leg-press and bench-press 1-RM (p = 0.026 and p = 0.008, respectively, and a tendency toward lower handgrip strength (p = 0.052. C-SLE showed lower TST scores (p = 0.036 and a tendency toward higher TUG scores (p = 0.070 when compared with CTRL. Conclusion: Physically inactive C-SLE patients with very mild disease showed reduced muscle strength and functionality when compared with healthy controls matched by physical activity levels. These findings suggest C-SLE patients may greatly suffer from a physically inactive lifestyle than healthy controls do. Moreover, some sub-clinical “residual” effect of the disease or its pharmacological treatment seems to affect C-SLE patients even with a well-controlled disease.

  10. Eccentric exercise slows in vivo microvascular reactivity during brief contractions in human skeletal muscle.

    Science.gov (United States)

    Larsen, Ryan G; Hirata, Rogerio P; Madzak, Adnan; Frøkjær, Jens B; Graven-Nielsen, Thomas

    2015-12-01

    Unaccustomed exercise involving eccentric contractions results in muscle soreness and an overall decline in muscle function, however, little is known about the effects of eccentric exercise on microvascular reactivity in human skeletal muscle. Fourteen healthy men and women performed eccentric contractions of the dorsiflexor muscles in one leg, while the contralateral leg served as a control. At baseline, and 24 and 48 h after eccentric exercise, the following were acquired bilaterally in the tibialis anterior muscle: 1) transverse relaxation time (T2)-weighted magnetic resonance images to determine muscle cross-sectional area (mCSA) and T2; 2) blood oxygen level-dependent (BOLD) images during and following brief, maximal voluntary contractions (MVC) to monitor the hyperemic responses with participants positioned supine in a 3T magnet; 3) muscle strength; and 4) pain pressure threshold. Compared with the control leg, eccentric exercise resulted in soreness, decline in strength (∼20%), increased mCSA (∼7%), and prolonged T2 (∼7%) at 24 and 48 h (P eccentric exercise, such that time-to-peak (∼35%, P eccentric exercise may impede rapid adjustments in muscle blood flow at exercise onset and during activities involving brief bursts of muscle activation, which may impair O2 delivery and contribute to reduced muscle function after eccentric exercise. Copyright © 2015 the American Physiological Society.

  11. Fetal-onset severe skeletal muscle glycogenosis associated with phosphorylase-b kinase deficiency.

    Science.gov (United States)

    Bührer, C; van Landeghem, F; Brück, W; Felderhoff-Müser, U; Vorgerd, M; Obladen, M

    2000-04-01

    We report on a premature newborn girl delivered after 32 weeks of gestation by cesarean section after sparse limb movements, fetal tachycardia and late heart rate decelerations had suggested fetal distress. Following 1 day of mechanical ventilation, adequate pulmonary gas exchange was achieved by spontaneous breathing. Main symptoms were virtually complete absence of spontaneous movements, increased flexor tonus of the extremities, and hypotonia of the trunk. Inability to suck or swallow required nasogastric gavage feeding. There were no hypoglycemic episodes. Echocardiography revealed normal myocardial function. Creatine kinase was 237 U/I at 2 days of life, declining to normal values thereafter. Muscle biopsy revealed increased glycogen storage with subsarcolemmal glycogen deposits and low phosphorylase-a activity while total phosphorylase was normal after in vitro activation, suggestive of phosphorylase-b kinase deficiency. No mutation was detected in exon 1 of the myophosphorylase gene. No psychomotor development was observed, and the infant died of central apnea at 3 months of age.

  12. Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study

    NARCIS (Netherlands)

    A.T. van der Ploeg (Ans); Carlier, P.G. (Pierre G.); Carlier, R.-Y. (Robert-Yves); Kissel, J.T. (John T.); B. Schoser; Wenninger, S. (Stephan); Pestronk, A. (Alan); Barohn, R.J. (Richard J.); Dimachkie, M.M. (Mazen M.); Goker-Alpan, O. (Ozlem); Mozaffar, T. (Tahseen); Pena, L.D.M. (Loren D.M.); Simmons, Z. (Zachary); V. Straub; Guglieri, M. (Michela); Young, P. (Peter); Boentert, M. (Matthias); Baudin, P.-Y. (Pierre-Yves); S.C.A. Wens (Stephan); Shafi, R. (Raheel); Bjartmar, C. (Carl); B. Thurberg

    2016-01-01

    textabstractBackground Late-onset Pompe disease is characterized by progressive skeletal myopathy followed by respiratory muscle weakness, typically leading to loss of ambulation and respiratory failure. In this population, enzyme replacement therapy (ERT) with alglucosidase alfa has been shown to

  13. Electrical stimulation for pressure sore prevention and wound healing.

    Science.gov (United States)

    Bogie, K M; Reger, S I; Levine, S P; Sahgal, V

    2000-01-01

    This paper reviews applications of therapeutic electrical stimulation (ES) specific to wound healing and pressure sore prevention. The application of ES for wound healing has been found to increase the rate of healing by more than 50%. Furthermore, the total number of wounds healed is also increased. However, optimal delivery techniques for ES therapy have not been established to date. A study of stimulation current effects on wound healing in a pig model has shown that direct current (DC) stimulation is most effective in wound area reduction and alternating current (AC) stimulation for wound volume reduction at current densities of 127 microA/cm2 and 1,125 microA/cm2, respectively. Preliminary studies have been carried out at two research centers to assess the role of ES in pressure sore prevention. Surface stimulation studies have shown that ES can produce positive short-term changes in tissue health variables such as regional blood flow and pressure distribution. The use of an implanted stimulation system consisting of intramuscular electrodes with percutaneous leads has been found to produce additional long-term changes. Specifically, gluteal muscle thickness increased by 50% with regular long-term ES application concurrent with a 20% decrease in regional interface pressures and increased tissue oxygen levels. These findings indicate that an implantable ES system may have great potential for pressure sore prevention, particularly for individuals who lack sensation or who are physically unable to perform regular independent pressure relief.

  14. Pressure sore prevention in acutely ill patients.

    Science.gov (United States)

    James, H

    1997-03-01

    A wide range of factors affect the skin's ability to withstand pressure, friction and shear. Clinically validated pressure-relieving equipment is essential to prevent pressure sores in acutely ill patients. A successful pressure sore prevention strategy depends on sufficient resource allocation, appropriate levels and types of preventive equipment and evaluation.

  15. Evidence-based medicine: pressure sores.

    Science.gov (United States)

    Cushing, Carolyn A; Phillips, Linda G

    2013-12-01

    After studying this article, the participant should be able to: 1. Cite risk factors for pressure sore development. 2. Detail the pathophysiology of pressure sores. 3. List the types and classification of pressure sores. 4. Consider the various nonsurgical conservative wound management strategies. 5. Describe the appropriate surgical interventions for each pressure sore type. 6. Understand the causes of recurrent pressure sores and methods of avoiding recurrence. Pressure sores are the result of unrelieved pressure, usually over a bony prominence. With an estimated 2.5 million pressure ulcers treated annually in the United States at a cost of $11 billion, pressure sores represent a costly and labor-intensive challenge to the health care system. A comprehensive team approach can address both prevention and treatment of these recalcitrant wounds. Consideration must be given to the patient's medical and socioeconomic condition, as these factors are significantly related to outcomes. Mechanical prophylaxis, nutritional optimization, treatment of underlying infection, and spasm control are essential in management. A variety of pressure sore patterns exist, with surgical approaches directed to maximize future coverage options. A comprehensive approach is detailed in this article to provide the reader with the range of treatment options available.

  16. Pressure sore prevention in nursing homes.

    Science.gov (United States)

    Clay, M

    Staff working in nursing homes are caring for increasingly dependent residents who are consequently at great risk of developing pressure sores. Mary Clay offers a guide to the essential principles of pressure sore prevention as a teaching aid for all caring staff.

  17. The limits of pressure sore prevention.

    Science.gov (United States)

    Hagisawa, S; Barbenel, J

    1999-11-01

    Pressure sore prevalence and incidence were assessed in 275 patients who were admitted to a well-staffed internal medicine ward during a 12-month study period or who were present on day 1. Pressure sore risk was assessed by use of the Braden scale and patients scoring 16 or less were provided with intensive preventive care. During the study period 5.1% (95% confidence interval 2.7-7.8) of 275 patients had pressure sores (prevalence) and 4.4% (1.9-6.9) developed sores (incidence). None of the 239 patients who were assessed as not being at risk developed a sore. 36 patients were assessed as being at risk at some time during the study and 12 of these developed sores despite receiving high-quality preventive care. The results suggest that not all pressure sores can be prevented in severely ill patients. We believe that the 4.4% incidence of sores in this study approaches the current limit of prevention.

  18. The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration

    Directory of Open Access Journals (Sweden)

    Richard A. Perry Jr.

    2016-09-01

    Full Text Available The data described herein is related to the article “Differential Effects of Leucine Supplementation in Young and Aged Mice at the Onset of Skeletal Muscle Regeneration” [1]. Aging is associated with a decreased ability of skeletal muscle to regenerate following injury. Leucine supplementation has been extensively shown, in young subjects, to promote protein synthesis during regeneration; however, the effects of leucine supplementation on the Akt/mTOR pathway in aged mice at the onset of muscle regeneration are not fully elucidated. In this article, we present data on the Akt/mTOR protein synthesis pathway at the onset of muscle regeneration in young and aged C57BL/6J mice that are and are not receiving leucine supplementation. More specifically, protein content of total Akt, mTOR, p70S6K and 4EBP-1 are presented. Additionally, we provide relative (phosphorylated:total protein content comparisons of these targets as they present themselves in young and aged mice who have neither been injured nor received leucine supplementation. Lastly, markers of atrophy (FoxO1/O3, MuRF-1, Atrogin-1 are also reported in these young and aged control groups.

  19. Sore Throat: Symptoms and Causes

    Science.gov (United States)

    ... may be complicated by postnasal drip, which can irritate and inflame the throat. Dryness. Dry indoor air, ... drinking alcohol and eating spicy foods also can irritate your throat. Muscle strain. You can strain muscles ...

  20. Late-onset muscle weakness in partial phosphofructokinase deficiency: a unique myopathy with vacuoles, abnormal mitochondria, and absence of the common exon 5/intron 5 junction point mutation.

    Science.gov (United States)

    Sivakumar, K; Vasconcelos, O; Goldfarb, L; Dalakas, M C

    1996-05-01

    Three patients (ages 51, 59, and 79) from two generations of an Ashkenazi Jewish family had partial (33% activity) phosphofructokinase (PFK) deficiency that presented with fixed muscle weakness after the age of 50 years. MR spectroscopy revealed accumulation of phosphomonoesters during exercise. Muscle biopsy showed a vacuolar myopathy with increased autophagic activity and several ragged-red and cytochrome c oxidase-negative fibers. The older patient, age 79 at biopsy, had several necrotic fibers. Electron microscopy revealed subsarcolemmal and intermyofibrillar glycogen accumulation and proliferation of mitochondria with paracrystalline inclusions, probably related to reduced availability of energy due to impaired glycolysis. The common point mutation of exon 5/intron 5 junction seen in Jewish Ashkenazi patients with PFK deficiency was excluded. We conclude that late-onset fixed muscle weakness occurs in partial PFK deficiency and it may represent the end result of continuing episodes of muscle fiber destruction. Partial enzyme deficiency in two successive generations suggests a unique molecular mechanism.

  1. Eccentric exercise inhibits the H reflex in the middle part of the trapezius muscle

    DEFF Research Database (Denmark)

    Vangsgaard, Steffen; Nørgaard, Lars Tønners; Korsholm Flaskager, Brian

    2013-01-01

    The objectives of this study were to (1) investigate the modulation of the H reflex immediately after and 24 h after eccentric exercise in the presence of delayed-onset muscle soreness (DOMS) and (2) test the reproducibility of the H reflex in trapezius across days. H reflexes were recorded from...... the dominant middle trapezius muscle by electrical stimulation of the C3/4 cervical nerve in ten healthy subjects. DOMS was induced by eccentric exercise of the dominant shoulder. H reflexes were obtained in four sessions: "24 h before", "Pre", "Post", and "24 h after" eccentric exercise. Ratios of maximal H...

  2. Repair of pressure sores over ischial tuberosity with long head of biceps femoris muscle flap combined with semi-V posterior thigh fasciocutaneous flap%股二头肌长头肌瓣联合半V形股后筋膜皮瓣修复坐骨结节压疮

    Institute of Scientific and Technical Information of China (English)

    海恒林; 申传安; 柴家科; 李华涛

    2012-01-01

    Objective To explore the clinical effect of transplantation of the long head of biceps femoris muscle flap in combination with semi-V posterior thigh fasciocutaneous flap for repair of pressure sores over ischial tuberosity. Methods Eight patients with 10 deep pressure sores over ischial tuberosity were admitted to the First Affiliated Hospital to the PLA General Hospital and the 98th Hospital of PLA from April 2004 to June 2010.The wounds measured from 2 cm × 2 cm to 6 cm ×4 cm were covered with the long head of biceps femoris muscle flap and semi-V posterior thigh fasciocutaneous flap(ranged from 10 cm ×6 cm to 13 cm × 8 cm).The condition of flaps was observed and followed up for a long time. Results All flaps survived.Nine wounds healed by first intention.Subcutaneous accumulation of fluids occurred in one wound with formation of a sinus at drainage site,and it healed after dressing change for 25 days.Patients were followed up for 7 to 34 months.Sore recurred in one patient 9 months after surgery,and it was successfully repaired with the same flap for the second time.Flaps in the other 7 patients appeared satisfactory with soft texture and without ulceration. Conclusions This combined flap is easy in formation and transfer,and it causes little side injury with good resistance against pressure.It is a new method for repair of pressure sore over sacral region.%目的 观察应用股二头肌长头肌瓣联合半V形股后筋膜皮瓣修复坐骨结节压疮的临床疗效. 方法 选择2004年4月-2010年6月2家笔者单位收治的坐骨结节深度压疮患者8例共10处创面,压疮范围2cm×2 cm~6 cm ×4cm.设计股二头肌长头肌瓣和半V形股后筋膜皮瓣进行修复,其中股后筋膜皮瓣大小为10 cm ×6 cm ~13 cm×8 cm.统计术后皮瓣成活情况,并进行远期随访. 结果 术后皮瓣全部成活,其中9处压疮切口术后顺利愈合;1处因皮瓣下积液引流部位形成窦道,经换药治疗于术后25 d愈合.随访7

  3. Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.

    Science.gov (United States)

    Nunes, Andreia M; Wuebbles, Ryan D; Sarathy, Apurva; Fontelonga, Tatiana M; Deries, Marianne; Burkin, Dean J; Thorsteinsdóttir, Sólveig

    2017-06-01

    Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a dramatic neuromuscular disease in which crippling muscle weakness is evident from birth. Here, we use the dyW mouse model for human MDC1A to trace the onset of the disease during development in utero. We find that myotomal and primary myogenesis proceed normally in homozygous dyW-/- embryos. Fetal dyW-/- muscles display the same number of myofibers as wildtype (WT) muscles, but by E18.5 dyW-/- muscles are significantly smaller and muscle size is not recovered post-natally. These results suggest that fetal dyW-/- myofibers fail to grow at the same rate as WT myofibers. Consistent with this hypothesis between E17.5 and E18.5 dyW-/- muscles display a dramatic drop in the number of Pax7- and myogenin-positive cells relative to WT muscles, suggesting that dyW-/- muscles fail to generate enough muscle cells to sustain fetal myofiber growth. Gene expression analysis of dyW-/- E17.5 muscles identified a significant increase in the expression of the JAK-STAT target gene Pim1 and muscles from 2-day and 3-week old dyW-/- mice demonstrate a dramatic increase in pSTAT3 relative to WT muscles. Interestingly, myotubes lacking integrin α7β1, a laminin-receptor, also show a significant increase in pSTAT3 levels compared with WT myotubes, indicating that α7β1 can act as a negative regulator of STAT3 activity. Our data reveal for the first time that dyW-/- mice exhibit a myogenesis defect already in utero. We propose that overactivation of JAK-STAT signaling is part of the mechanism underlying disease onset and progression in dyW-/- mice. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. Muscle damage induced by electrical stimulation.

    Science.gov (United States)

    Nosaka, Kazunori; Aldayel, Abdulaziz; Jubeau, Marc; Chen, Trevor C

    2011-10-01

    Electrical stimulation (ES) induces muscle damage that is characterised by histological alterations of muscle fibres and connective tissue, increases in circulating creatine kinase (CK) activity, decreases in muscle strength and development of delayed onset muscle soreness (DOMS). Muscle damage is induced not only by eccentric contractions with ES but also by isometric contractions evoked by ES. Muscle damage profile following 40 isometric contractions of the knee extensors is similar between pulsed current (75 Hz, 400 μs) and alternating current (2.5 kHz delivered at 75 Hz, 400 μs) ES for similar force output. When comparing maximal voluntary and ES-evoked (75 Hz, 200 μs) 50 isometric contractions of the elbow flexors, ES results in greater decreases in maximal voluntary contraction strength, increases in plasma CK activity and DOMS. It appears that the magnitude of muscle damage induced by ES-evoked isometric contractions is comparable to that induced by maximal voluntary eccentric contractions, although the volume of affected muscles in ES is not as large as that of eccentric exercise-induced muscle damage. It seems likely that the muscle damage in ES is associated with high mechanical stress on the activated muscle fibres due to the specificity of motor unit recruitment (i.e., non-selective, synchronous and spatially fixed manner). The magnitude of muscle damage induced by ES is significantly reduced when the second ES bout is performed 2-4 weeks later. It is possible to attenuate the magnitude of muscle damage by "pre-conditioning" muscles, so that muscle damage should not limit the use of ES in training and rehabilitation.

  5. Unilateral eccentric exercise of the knee flexors affects muscle activation during gait.

    Science.gov (United States)

    Dover, Geoffrey C; Legge, Laura; St-Onge, Nancy

    2012-05-01

    Uni-lateral muscle soreness is common yet the effects on gait or electromyographic (EMG) activity are unknown. The purpose of our study was to induce delayed onset muscle soreness (DOMS) in the knee flexor group and measure the resultant change in EMG activity and knee motion during gait. Nine healthy subjects participated in the study. Measures of function, evoked tenderness of the biceps femoris, as well as knee angle, and EMG activity during gait were assessed prior and 48 h after an eccentric exercise protocol. DOMS was induced unilaterally in the knee flexors using an isokinetic dynamometer and subjects exercised until they could not generate 50% of their maximal voluntary isometric contraction (MVIC). There was a significant decrease in biceps femoris activity after DOMS during the last phase of gait. Moreover, there was a day × phase interaction for gastrocnemius activity with the last two phases displaying an increase in activity. There was no significant change in knee angle during gait. The decrease in biceps femoris activity as well as the increase in gastrocnemius activity could be evidence of a protective mechanism designed to decrease activity of the sore muscle while increasing the activity of a synergistic muscle. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. Why Are My Breasts Sore? (For Teens)

    Science.gov (United States)

    ... sure? Why Do I Have Breasts Anyway? All mammals have breasts and humans are no exception. Breasts, ... Ache? Most PMS symptoms, including breast soreness, should disappear as your period begins. Over-the-counter pain ...

  7. How to care for pressure sores

    Science.gov (United States)

    ... Hips Heels Ankles Shoulders Back Back of head Caring for a Pressure Sore Stage I or II ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  8. Free flaps for pressure sore coverage.

    Science.gov (United States)

    Lemaire, Vincent; Boulanger, Kevin; Heymans, Oliver

    2008-06-01

    Management of pressure sores still represents a major challenge in plastic surgery practice due to recurrence. The surgeon may have to face multiple or recurrent pressure ulcerations without any local flap left. In this very limited indication, free flap surgery appears to be a useful adjunct in the surgical treatment. We reviewed our charts looking for patients operated for a pressure sore of the sacral, ischial, or trochanteric region. We found 88 consecutive patients representing 108 different pressure sores and 141 flap procedures. Among these patients, 6 presented large sores that could not be covered with a pedicled flap and benefited from free flap surgery (4.2% of all procedures). Stable coverage was achieved in 80% of these patients after a mean follow-up of 32 months. Comparison between pedicled and free flaps groups showed a trend in the latest concerning the presence of diabetes, incontinence, paraplegia, and male sex.

  9. Elevated creatine kinase does not necessarily correspond temporally with onset of muscle rigidity in neuroleptic malignant syndrome: a report of two cases

    Directory of Open Access Journals (Sweden)

    Nisijima K

    2012-12-01

    Full Text Available Koichi NisijimaDepartment of Psychiatry, Jichi Medical University, Tochigi, JapanAbstract: Neuroleptic malignant syndrome is an uncommon but dangerous complication of antipsychotic drugs, characterized by clinical symptoms that include hyperthermia, severe muscle rigidity, autonomic dysfunction, and altered mental state. Serum creatine kinase (CK elevation occurs in over 90% of cases. Many diagnostic criteria sets for neuroleptic malignant syndrome have been proposed, all of which include hyperthermia and muscle rigidity as major symptoms, and serum CK elevation as either a major or minor symptom. In general, elevated CK occurs in the initial stage of neuroleptic malignant syndrome and corresponds temporally with the onset of muscle rigidity. However, in some exceptional cases, CK elevation and emergence of muscle rigidity do not appear in the same stage, making early diagnosis of neuroleptic malignant syndrome more difficult. Two rare cases of neuroleptic malignant syndrome are presented in which elevated serum CK and emergence of muscle rigidity did not occur in the same stage of neuroleptic malignant syndrome. An elevated CK level is common in the early stage of neuroleptic malignant syndrome, suggesting that serum CK elevation is a useful indicator for early detection of neuroleptic malignant syndrome. However, a definitive diagnosis of neuroleptic malignant syndrome must be determined from the presence of specific clinical symptoms.Keywords: neuroleptic malignant syndrome, creatine kinase, muscle rigidity

  10. Pressure sore risk assessment in palliative care.

    Science.gov (United States)

    Chaplin, J

    2000-01-01

    Pressure sore prevention in palliative care is recognized as being an essential element of holistic care, with the primary goal of promoting quality of life for patient and family. Little is known about the incidence of pressure sore development and the use of pressure sore risk assessment tools in palliative care settings. The development of a risk assessment tool specifically for palliative care patients in a 41-bedded specialist palliative care unit is described. The risk assessment tool was developed as part of a tissue viability practice development initiative. The approach adopted in the validation of the Hunters Hill Marie Curie Centre pressure sore risk assessment tool was the comparative analysis of professional judgment of experienced palliative care nurses with the numerical scores achieved during the assessment of risk on 291 patients (529 risk assessment events). This comparative analysis identified the threshold for different degrees of risk for the patient group involved: low risk, medium risk, high risk and very high risk. Further work is being undertaken to evaluate the inter-rater reliability of the new tool. A number of issues are explored in this paper in relation to pressure sore prevention in palliative care: the role of risk assessment tools, the sometimes conflicting aims of trying to ensure comfort and prevent pressure sore damage, and the uncertainties faced by palliative care nurses when they are trying to maintain quality of life for the dying.

  11. Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation.

    Science.gov (United States)

    Nunan, David; Howatson, Glyn; van Someren, Ken A

    2010-02-01

    The purpose of this study was to examine the effects of combined oral beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) supplementation on indices of exercise-induced muscle damage (EIMD) after an acute bout of eccentric-biased exercise. Fourteen male subjects were allocated to 2 groups: a placebo group (3 g.d corn flour, N = 7) or an HMB + KIC group (3 g.d HMB and 0.3 g.d KIC, N = 7). Supplementation commenced 11 days before a 40-minute bout of downhill running and continued for 3 days post-exercise. Delayed-onset muscle soreness, mid-thigh girth, knee extensor range of motion, serum creatine kinase (CK) activity, and isometric and concentric torque were assessed pre-exercise and at 24, 48, and 72 hours post-exercise. Delayed-onset muscle soreness, CK activity, and isometric and concentric torque all changed over the 72-hour period (p < 0.05); however, HMB + KIC had no significant effect on any of the indices of muscle damage. Although 14 days HMB and KIC supplementation did not attenuate indices of EIMD after an acute bout of unaccustomed eccentric-biased exercise, there was a trend for a more rapid rate of recovery in isometric and isokinetic muscle function. beta-hydroxy-beta-methylbutyrate and KIC may therefore provide limited benefit in the recovery of muscle function after EIMD in untrained subjects or after unaccustomed exercise.

  12. Contraction induced muscle injury: towards personalized training and recovery programs.

    Science.gov (United States)

    Givli, Sefi

    2015-02-01

    Skeletal muscles can be injured by their own contractions. Such contraction-induced injury, often accompanied by delayed onset of muscle soreness, is a leading cause of the loss of mobility in the rapidly increasing population of elderly people. Unlike other types of muscle injuries which hurt almost exclusively those who are subjected to intensive exercise such as professional athletes and soldiers in training, contraction induced injury is a phenomenon which may be experienced by people of all ages while performing a variety of daily-life activities. Subjects that experience contraction induced injury report on soreness that usually increases in intensity in the first 24 h after the activity, peaks from 24 to 72 h, and then subsides and disappears in a few days. Despite their clinical importance and wide influence, there are almost no studies, clinical, experimental or computational, that quantitatively relate between the extent of contraction induced injury and activity factors, such as number of repetitions, their frequency and magnitude. The lack of such quantitative information is even more emphasized by the fact that contraction induced injury can be used, if moderate and controlled, to improve muscle performance in the long term. Thus, if properly understood and carefully implemented, contraction induced injury can be used for the purpose of personalized training and recovery programs. In this paper, we review experimental, clinical, and theoretical works, attempting towards drawing a more quantitative description of contraction induced injury and related phenomena.

  13. ATP, IMP, and glycogen in cod muscle at onset and during development of rigor mortis depend on the sampling location

    DEFF Research Database (Denmark)

    Cappeln, Gertrud; Jessen, Flemming

    2002-01-01

    Variation in glycogen, ATP, and IMP contents within individual cod muscles were studied in ice stored fish during the progress of rigor mortis. Rigor index was determined before muscle samples for chemical analyzes were taken at 16 different positions on the fish. During development of rigor, the...

  14. Application of skin traction for surgical treatment of grade IV pressure sore: a clinical report of 160 cases.

    Science.gov (United States)

    Chen, X; Jiang, Z; Chen, Z; Wang, D

    2011-01-01

    Retrospective clinical study. To assess the method of primary surgical closure of pressure sores developed by the Ruixin Hospital for burns. Nanjing, China. The study included 235 grade IV pressure sores of 160 patients, M:F = 119:41. Their age ranged from 19 to 93 years (mean = 47.4, s.d. ± 15.7). The primary disease was spinal cord injury in 141 patients (88.1%). The location of sore spread over ischial, sacrococcygeal and trochanteric regions. The largest pressure sore measured 15 × 25 cm(2). The time from onset of sore to admission ranged from 3 months to 22 years (mean = 35.5 months, s.d. ± 55.8). Local preoperative preparation included external skin traction using adhesive tapes, wound cleaning and change of dressing. General condition was checked and improved by supportive measures. Operation procedures included thorough debridement, excision of hidden minor scars, mobilizing opposing skin flaps and meticulous haemostasis before closure. Skin traction continued after the operation until the wound was healed. All but 10 sores healed primarily. These 10 sores healed after a revision. The length of stay in hospital ranged from 20 to 140 days (mean = 45.1 days, s.d. ± 21.1). Follow-up period was 2-51 months (mean = 22 months, s.d. ± 12.5). Two ischial sores recurred owing to long sitting. They were cured with the same method. Three illustrative cases are presented. The method is simple and enjoys a high success rate with a short stay in hospital and hence is cost effective. The recurrence is rare.

  15. An audit of the physiotherapy management of paraplegic patients with sacral pressure sores

    Directory of Open Access Journals (Sweden)

    D. Pather

    2013-01-01

    Full Text Available Introduction: Pressure sores are the most common complication post spinal cord injury that requires patients to be on bed rest. Patient bed rest delay rehabilitation and may lead to other complications associated with immobility. This study sought to establish the treatment interventions physiotherapists provide to patients with sacral pressure sores and the factors that they consider when deciding whether the patient should receive physiotherapy in the ward or gym. Methods: This was a questionnaire based survey of physiotherapists working in spinal cord injury rehabilitation units in South Africa. The self-designed questionnaire was sent to all the main spinal rehabilitation units in the country (14 located in Gauteng, Kwa-Zulu Natal, Western Cape, Eastern Cape and Free State provinces. Results: Thirty-nine physiotherapists from a total of 51 completed the questionnaires (76% response rate. The most common treatment practice for patients with sacral pressure sores was bed rest (98%. The most common physio-therapy practices (70% included were upper limb muscle strengthening, upper and lower limb passive movements, positioning into prone and side lying and passive stretching. The choice of treatment environment was influenced by doctors’ orders and the size, grade and duration of the pressure sores. Conclusion: Direct involvement in pressure sore management in South Africa seem to be less than in other parts of the world. If we are to minimise the pressure sore impact, it appears like we need more focus on gait re-education and standardised ADL programmes and patient treatment in the gym to possibly maximise healing and rehabilitation.

  16. North American ginseng protects against muscle damage and reduces neutrophil infiltration after an acute bout of downhill running in rats.

    Science.gov (United States)

    Estaki, Mehrbod; Noble, Earl G

    2015-02-01

    Eccentric muscle contractions such as those experienced during downhill running are associated with inflammation, delayed-onset of muscle soreness, myofiber damage, and various functional deficits. North American ginseng (Panax quinquefolius L.) has been reported to possess anti-inflammatory properties and thus may offset some of this exercise-induced damage. Hence, we tested the hypothesis that intervention with North American ginseng would reduce eccentric exercise-induced muscle damage and inflammation. Male Wistar rats were fed (300 mg/(kg·day)(-1)) of either an alcohol (AL) or aqueous (AQ) extract of North American ginseng for 14 days before a single bout of downhill running and were compared with matching nonexercised (C) groups. Plasma creatine kinase levels were significantly reduced in both ginseng treated groups compared with the C group that received a water placebo (p damage (hemotoxylin and eosin) as well as reduced levels of infiltrating neutrophils (HIS48) in the soleus muscle (p muscle damage and inflammation.

  17. Pressure sore survey. Part 3: Locus of control.

    Science.gov (United States)

    Maylor, M; Torrance, C

    1999-03-01

    This is the third in a three-part article which investigates the prevalence, knowledge and attitudes to pressure sores in one NHS trust. This study describes the methodology used in choosing and developing attitude scales to explore whether there are any relationships between the locus of control and pressure sore prevention. Factors to do with attitude and the value associated with pressure sore prevention have a central role. Attitudes and beliefs affect what we do and may contribute to pressure sore development.

  18. Silicone moulding for pressure sore debridement.

    Science.gov (United States)

    Erba, P; Wettstein, R; Schumacher, R; Schwenzer-Zimmerer, K; Pierer, G; Kalbermatten, D F

    2010-03-01

    The radicality of wound debridement is an important feature of the surgical treatment of pressure sores. Several methods such as injection of methylene blue or hydrogen peroxide have been proposed to facilitate and optimise the surgical debridement technique, but none of them proved to be sufficient. We present an innovative modification of the pseudo-tumour technique consisting in the injection of fluid silicone. Vulcanization of the silicone leads to pressure-sore moulding, permitting a more radical and sterile excision. In a series of 10 paraplegic patients presenting with ischial pressure sores, silicone moulding was used to facilitate debridement. Radical en bloc debridement was achieved in all patients. After a minimal follow-up of 2 years, no complications and recurrences occurred. A three-dimensional (3D) analysis of the silicone prints objectified the pyramidal shape of ischial pressure sores. Our study showed that complete resection without capsular lesion can be easily achieved. Further, it allows the surgeon to analyse the shape and size of the resected defect, which might be helpful to select the appropriate defect coverage technique. (c) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  19. The effects of PGC-1α on control of microvascular P(O2) kinetics following onset of muscle contractions.

    Science.gov (United States)

    Kano, Yutaka; Miura, Shinji; Eshima, Hiroaki; Ezaki, Osamu; Poole, David C

    2014-07-15

    During contractions, regulation of microvascular oxygen partial pressure (Pmv(O2)), which drives blood-myocyte O2 flux, is a function of skeletal muscle fiber type and oxidative capacity and can be altered by exercise training. The kinetics of Pmv(O2) during contractions in predominantly fast-twitch muscles evinces a more rapid fall to far lower levels compared with slow-twitch counterparts. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) improves endurance performance, in part, due to mitochondrial biogenesis, a fiber-type switch to oxidative fibers, and angiogenesis in skeletal muscle. We tested the hypothesis that improvement of exercise capacity by genetic overexpression of PGC-1α would be associated with an altered Pmv(O2) kinetics profile of the fast-twitch (white) gastrocnemius during contractions toward that seen in slow-twitch muscles (i.e., slowed response kinetics and elevated steady-state Pmv(O2)). Phosphorescence quenching techniques were used to measure Pmv(O2) at rest and during separate bouts of twitch (1 Hz) and tetanic (100 Hz) contractions in gastrocnemius muscles of mice with overexpression of PGC-1α and wild-type littermates (WT) mice under isoflurane anesthesia. Muscles of PGC-1α mice exhibited less fatigue than WT (P contractions, WT and PGC-1α mice demonstrated similar Pmv(O2) kinetics. Specifically, the time delay of the Pmv(O2) response was shortened in PGC-1α mice compared with WT (1 Hz: WT, 6.6 ± 2.4 s; PGC-1α, 2.9 ± 0.8 s; 100 Hz: WT, 3.3 ± 1.1 s, PGC-1α, 0.9 ± 0.3 s, both P contractions in PGC-1α mice. Slower dynamics and maintenance of higher Pmv(O2) following muscle contractions is not obligatory for improved fatigue resistance in fast-twitch muscle of PGC-1α mice. Moreover, overexpression of PGC-1α may accelerate O2 utilization kinetics to a greater extent than O2 delivery kinetics.

  20. Fatty infiltrate in the cervical extensor muscles is not a feature of chronic, insidious-onset neck pain

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, J. [Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane (Australia); Department of Physical Therapy, Rueckert-Hartman School for Health Professions, Regis University, Denver, Colorado (United States); Centre for Magnetic Resonance, University of Queensland, Brisbane (Australia)], E-mail: jelltt@regis.edu; Sterling, M. [Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane (Australia); Noteboom, J.T. [Department of Physical Therapy, Rueckert-Hartman School for Health Professions, Regis University, Denver, Colorado (United States); Darnell, R. [Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane (Australia); Galloway, G. [Centre for Magnetic Resonance, University of Queensland, Brisbane (Australia); Jull, G. [Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane (Australia)

    2008-06-15

    Aim: To investigate the presence of fatty infiltrate in the cervical extensor musculature in patients with insidious-onset neck pain to better understand the possible pathophysiology underlying such changes in chronic whiplash-associated disorders (WAD). Materials and methods: A sample of convenience of 23 women with persistent insidious-onset neck pain (mean age 29.2 {+-} 6.9 years) was recruited for the study. Magnetic resonance imaging (MRI) was used to quantify fatty infiltration in the cervical extensor musculature. Quantitative Sensory Testing (QST; pressure and thermal pain thresholds) was performed as sensory features are present in chronic whiplash. Self-reported pain and disability, as well as psychological distress, were measured using the Neck Disability Index (NDI) and the General Health Questionnaire-28 (GHQ-28), respectively. Results: Measures were compared with those of a previous dataset of chronic whiplash patients (n = 79, mean age 29.7 {+-} 7.8 years). Using a classification tree, insidious-onset neck pain was clearly identified from whiplash (p < 0.001), based on the presence of MRI fatty infiltrate in the cervical extensor musculature (0/102 individuals) and altered temperature thresholds (cold; 3/102 individuals). Conclusion: Fatty infiltrates in the cervical extensor musculature and widespread hyperalgesia were not features of the insidious-onset neck pain group in this study; whereas these features have been identified in patients with chronic WAD. This novel finding may enable a better understanding of the underlying pathophysiological processes in patients with chronic whiplash.

  1. Uso do alongamento estático como fator interveniente na dor muscular de início tardio Use of static stretching as an intervenient factor in delayed onset muscle soreness

    OpenAIRE

    Aline Evans de Oliveira Bonfim; Daniela de Ré; Juliana Gaffuri; Marcela Medeiros de Almeida Costa; José Luiz Marinho Portolez; Gladson Ricardo Flor Bertolini

    2010-01-01

    INTRODUÇÃO: A dor muscular de início tardio consiste em uma sensação de desconforto muscular consequente da prática de exercício físico intenso, que perdura durante alguns dias. O alongamento estático pode ser usado para tentar amenizar esse efeito pós-exercício, mantendo-o durante cerca de 10-30 segundos e repetindo o procedimento por três a cinco vezes. OBJETIVO: Verificar, em indivíduos sedentários, o efeito do alongamento estático para o alívio da dor muscular de início tardio. MÉTODOS: E...

  2. The Mechanism of the Ischemic Reperfusion Injury - Delayed Onset Muscle Soreness%缺血再灌注损伤-延迟性肌肉酸痛的产生机制

    Institute of Scientific and Technical Information of China (English)

    周卫平

    2005-01-01

    通过比较大量心肌、骨骼肌缺血再灌注损伤和骨骼肌延迟性酸痛的研究结果,根据两者发生时间、超微结构的改变、主要生化指标的特征以及现有解释理论等方面,提出了缺血再灌注损伤是延迟性肌肉酸痛产生的机制这一假说,旨在为延迟性肌肉酸痛的进一步研究提供方向.

  3. Study of Delayed Onset Muscle Soreness in Healthy Volunteers with Magnetic Resonance Diffusion Tensor Imaging%健康志愿者延迟性肌肉酸痛磁共振扩散张量成像研究

    Institute of Scientific and Technical Information of China (English)

    王希海; 杨莹; 刘强; 张成军; 卢再鸣; 潘诗农; 郭启勇

    2014-01-01

    目的 应用扩散张量成像(DTI)分析健康志愿者股外侧肌延迟性肌肉酸痛(DOMS)影像学改变及其与肌肉酸痛指数之间的相关性,探讨DTI在评价DOMS中的应用价值.方法 9名健康志愿者运用短距离重复跑运动模式进行训练以获得DOMS模型,在运动前、运动后的1d、2d、3d、5d对左侧股四头肌进行DTI扫描,并行肌肉酸痛指数评分.测量左侧股外侧肌感兴趣区ADC值、FA值及本征值.运用重复测量资料的方差分析对各指标不同时间上的变化的特点.用Spearman秩相关分析对DTI测量结果与肌肉酸痛指数进行相关性分析.结果 9名健康志愿者左侧股外侧肌DTI检查显示左侧股外侧肌的ADC值在运动后24h逐渐增高,48 h达到高峰,72 h后逐渐降低,5d时逐渐恢复正常.FA值和λ3亦在运动后24 h~48 h逐渐增高,48 h时达最大值,后逐渐降低,5d时恢复正常,λ1,λ2亦显示出同样的变化趋势.统计学分析显示FA、λ3与肌肉酸痛指数有一定相关性(r值分别为0.577、0.214).结论 DTI能够有效评估DOMS后骨骼肌损伤程度改变,DTI与酸痛指数能够对DOMS进行综合评价,为运动训练提供科学的理论依据和指导.

  4. PNF牵伸对一次离心运动后骨骼肌DOMS恢复效果的研究%A Study of Effects of PNF on Delayed Onset Muscle Soreness Recovery after Acute Eccentric Exercise

    Institute of Scientific and Technical Information of China (English)

    闻剑飞; 郑小凤

    2016-01-01

    目的:本文旨在观察PNF牵伸对离心运动后DOMS的恢复效果.方法:16名健康男性大学生随机分为对照组和PNF组,同时完成3组十级蛙跳,每组3次十级蛙跳和组间30s鸭子步走,运动后PNF组在运动后即刻、24h、48h、72h、96h接受PNF牵伸.运动后测定两组在不同时刻肌肉酸痛程度和最大肌力.结果:与对照组相比,PNF组在运动后24h、48h、72h、96h肌肉酸痛程度明显降低(P<0.05),运动后96h PNF组最大肌力明显高于对照组(P<0.05).结论:PNF牵伸对减轻DOMS,促进肌肉力量恢复具有积极作用.

  5. Massage effects on delayed onset muscle soreness after acute eccentric exercise%推拿对一次性离心运动后延迟性肌肉酸痛的影响

    Institute of Scientific and Technical Information of China (English)

    熊英; 吴云川; 金宏柱; 顾一煌

    2009-01-01

    背景:推拿是运动性疲劳防治的常用手段之一,但有关推拿防治延迟性肌肉酸痛疗效的客观评价较少.目的:评价推拿对一次性离心运动后延迟性肌肉酸痛的影响.设计、时间及地点:对比观察,于2008-04/07在南京中医药大学完成.对象:将30名健康男性学生按照条件对等原则随机分成对照组和运动前推拿组、运动后推拿组共3组,每组10名,方法:运动前推拿组学生于训练前在左上肢进行30 min的推拿,推拿结束5 min后开始训练.运动后推拿组学生于训练后30 min在左上肢进行30 min的推拿,并在此后的3 d内按规定的时间继续接受推拿治疗,30 min/次,1次/d.对照组学生仅参加训练,不做任何的准备活动或整理活动,也不接受任何治疗.主要观察指标:观察训练前、训练后即刻、训练后24,48,72 h测定肌肉酸痛程度和持续时间、最大等长收缩力量、臂围、肘关节的屈伸度,训练前1 h、训练后即刻、训练后24,48 h血清肌酸激酶的变化.结果:与对照组相比,运动前推拿组、运动后推拿组的肌肉酸痛持续时间明显缩短,酸痛的程度明显减轻(P<0.01,P<0.05),运动后72 h的肌肉最大等长收缩力量的恢复明显(P<0.01),运动后72 h的血清肌酸激酶升高幅度明显降低.运动前推拿组运动后即刻的肘关节屈曲程度变化明显小于对照组(P<0.05),运动后推拿组在运动后72 h的肘关节伸直程度的恢复明显优于对照组(P<0 05):运动前推拿组、运动后推拿组的臂围变化与对照组无明显差异.结论:运动前推拿能一定程度预防延迟性肌肉酸痛,减轻延迟性肌肉酸痛的严重程度,而运动后推拿能一定程度促进延迟性肌肉酸痛的恢复.

  6. 中医防治延迟性肌肉酸痛的进展研究%THE RESEARCH ON CONTROLLING DELAYED ONSET MUSCLE SORENESS BY TRADITIONAL CHINESE MEDICINE

    Institute of Scientific and Technical Information of China (English)

    江红轲

    2009-01-01

    本文研究了如何应用中医学手段防治延迟性肌肉酸痛,采用文献回顾与前瞻性分析及逻辑推理相结合的方法,跟踪传统养生方法在对抗和治疗DMOS的研究成果和存在的问题.研究证实,按摩、针灸和中草药等各种传统中医手段对防治延迟性肌肉酸痛效果显著,因此进一步研究应用中医手段防治延迟性肌肉酸痛对大众健身和竞技体育的发展都具有深远的意义.

  7. Lower extremity muscle activation onset times during the transition from double-leg stance to single-leg stance in anterior cruciate ligament injured subjects.

    Science.gov (United States)

    Dingenen, Bart; Janssens, Luc; Luyckx, Thomas; Claes, Steven; Bellemans, Johan; Staes, Filip F

    2015-12-01

    The goal of this study was to evaluate muscle activation onset times (MAOT) of both legs during a transition task from double-leg stance (DLS) to single-leg stance (SLS) in anterior cruciate ligament injured (ACLI) (n=15) and non-injured control subjects (n=15) with eyes open and eyes closed. Significantly delayed MAOT were found in the ACLI group compared to the control group for vastus lateralis, vastus medialis obliquus, hamstrings medial, hamstrings lateral, tibialis anterior, peroneus longus and gastrocnemius in both vision conditions, for gluteus maximus and gluteus medius with eyes open and for tensor fascia latae with eyes closed. Within the ACLI group, delayed MAOT of tibialis anterior with eyes open and gastrocnemius with eyes closed were found in the injured leg compared to the non-injured leg. All other muscles were not significantly different between legs. In conclusion, the ACLI group showed delayed MAOT not only around the knee, but also at the hip and ankle muscles compared to the non-injured control group. No differences between both legs of the ACLI group were found, except for tibialis anterior and gastrocnemius. These findings indirectly support including central nervous system re-education training to target the underlying mechanisms of these altered MAOT after ACL injury.

  8. A novel late-onset axial myopathy associated with mutations in the skeletal muscle ryanodine receptor (RYR1) gene

    NARCIS (Netherlands)

    Loseth, S.; Voermans, N.C.; Torbergsen, T.; Lillis, S.; Jonsrud, C.; Lindal, S.; Kamsteeg, E.J.; Lammens, M.M.Y.; Broman, M.; Dekomien, G.; Maddison, P.; Muntoni, F.; Sewry, C.; Radunovic, A.; Visser, M. de; Straub, V.; Engelen, B.G.M. van; Jungbluth, H.

    2013-01-01

    Mutations in the skeletal muscle ryanodine receptor (RYR1) gene are a common cause of inherited neuromuscular disorders and have been associated with a wide clinical spectrum, ranging from various congenital myopathies to the malignant hyperthermia susceptibility (MHS) trait without any associated w

  9. Changes in electrical pain threshold of fascia and muscle after initial and secondary bouts of elbow flexor eccentric exercise.

    Science.gov (United States)

    Lau, Wing Yin; Blazevich, Anthony J; Newton, Michael J; Wu, Sam Shi Xuan; Nosaka, Kazunori

    2015-05-01

    This study investigated changes in electrical pain threshold (EPT) after repeated eccentric exercise bouts to test the hypothesis that fascia would become more sensitive than muscle when greater delayed onset muscle soreness (DOMS) is induced. Ten young men performed two eccentric exercise bouts (ECC1, ECC2) consisting of ten sets of six maximal isokinetic eccentric contractions of the elbow flexors with the same arm separated by 4 weeks. Maximal voluntary isometric contraction torque, range of motion, muscle soreness assessed by a visual analogue scale (VAS) and pressure pain threshold (PPT) were measured before, immediately after and 1-5 days after exercise. EPT was assessed in the biceps brachii fascia (BBF), biceps brachii muscle, and brachialis fascia (BF) 1 day before, immediately after, and 1, 2 and 4 days after exercise. All measures showed smaller changes (P fascia becomes more sensitive than muscle to electrical stimulation after the initial eccentric exercise, suggesting that damage inflammation to fascia than muscle fibres is more associated with DOMS.

  10. Delayed Onset Vascular Stiffening Induced by Eccentric Resistance Exercise and Downhill Running.

    Science.gov (United States)

    Lin, Hsin-Fu; Chou, Chun-Chung; Cheng, Hao-Min; Tanaka, Hirofumi

    2017-07-01

    Eccentric exercise induces muscle stiffening and soreness as well as unfavorable changes in macrovascular function. We tested the hypothesis that systemic eccentric exercise could evoke greater arterial stiffening than local eccentric resistance exercise. Twenty healthy young men were randomly assigned into either the downhill running (DR) and the eccentric resistance exercise (RE) group followed by a crossover design with an exercise and sham control trial. Carotid-femoral pulse wave velocity (cfPWV), central hemodynamic measures, and biomarkers were obtained. Muscle soreness and plasma creatine kinase concentrations increased similarly after exercise in both groups. The cfPWV increased significantly at 48 hours post-exercise in both groups and remained elevated at 72 hours in DR. C-reactive protein (CRP) was elevated at 24 and 48 hours in DR, and 48 hours in RE. The increases in cfPWV were associated with the corresponding elevations in CRP in DR (r = 0.70, P < 0.05). There were no changes in arterial wave reflection measures. Both systemic and localized eccentric exercise modes induced delayed onset vascular stiffening with more prolonged changes observed in downhill running. The effect on arterial stiffening was associated, at least in part, with systemic inflammatory responses.

  11. The principles of pressure sore prevention.

    Science.gov (United States)

    Quinn, D

    In the first Practice Profile to be published in Nursing Standard, Debbie Quinn demonstrates how studying a Continuing Education reader helped to develop an area of clinical practice--the prevention of pressure sores. Continuing Education Readers are made up of between four and six CPD (previously CE) articles and Debbie based her Profile on one of these. We will be publishing further Practice Profiles related to CPD articles.

  12. Dating the onset of some mutations in myostatin gene determining the double muscled phenotype in beef cattle

    Directory of Open Access Journals (Sweden)

    A. Nardone

    2011-03-01

    Full Text Available Growth differentiation factor 8 (GDF8 or myostatin is a member of the transforming growth factor β (TGF-β superfamily, which includes proteins that mediate key events in cell growth and development through signal transduction. In the absence of myostatin, the skeletal musculature of mice is two to three times greater in mass than that of wild-type mice (McPherron et al., 1997. Several cattle breeds are characterized by double muscling phenotype and GDF8 has been extensively investigated in cattle.A large number of variants have been identified in these species,most of which are silent or neutral.........

  13. Giant trochanteric pressure sore: Use of a pedicled chimeric perforator flap for cover

    Science.gov (United States)

    Mehrotra, Sandeep

    2009-01-01

    Pressure sores are increasing in frequency commensurate with an ageing population with multi-system disorders and trauma. Numerous classic options are described for providing stable wound cover. With the burgeoning knowledge on perforator anatomy, recent approaches focus on the use of perforator-based flaps in bedsore surgery. A giant neglected trochanteric pressure sore in a paraplegic is presented. Since conventional options of reconstruction appeared remote, the massive ulcer was successfully managed by a chimeric perforator-based flap. The combined muscle and fasciocutaneous flaps were raised as separate paddles based on the anterolateral thigh perforator branches and provided stable cover without complications. Perforators allow versatility in managing complex wounds without compromising on established principles. PMID:19881035

  14. Giant trochanteric pressure sore: Use of a pedicled chimeric perforator flap for cover

    Directory of Open Access Journals (Sweden)

    Mehrotra Sandeep

    2009-01-01

    Full Text Available Pressure sores are increasing in frequency commensurate with an ageing population with multi-system disorders and trauma. Numerous classic options are described for providing stable wound cover. With the burgeoning knowledge on perforator anatomy, recent approaches focus on the use of perforator-based flaps in bedsore surgery. A giant neglected trochanteric pressure sore in a paraplegic is presented. Since conventional options of reconstruction appeared remote, the massive ulcer was successfully managed by a chimeric perforator-based flap. The combined muscle and fasciocutaneous flaps were raised as separate paddles based on the anterolateral thigh perforator branches and provided stable cover without complications. Perforators allow versatility in managing complex wounds without compromising on established principles.

  15. Sore throat and hoarseness after total intravenous anaesthesia.

    Science.gov (United States)

    Maruyama, K; Sakai, H; Miyazawa, H; Toda, N; Iinuma, Y; Mochizuki, N; Hara, K; Otagiri, T

    2004-04-01

    Sore throat and hoarseness are common complications, but these have not been studied after total i.v. anaesthesia. We prospectively studied 418 surgical patients, aged 15-92 yr, after total i.v. anaesthesia with propofol, fentanyl and ketamine to assess possible factors associated with sore throat and hoarseness. We found sore throat in 50% and hoarseness in 55% of patients immediately after surgery. This decreased to 25% for sore throat and 24% for hoarseness on the day after surgery. Both sore throat and hoarseness were more common in females and when lidocaine spray had been used. Cricoid pressure during laryngoscopy was inversely associated with the risk of sore throat. Knowledge of these factors may reduce postoperative throat complications, and improve patient satisfaction.

  16. The effect of different skin-ankle brace application pressures on quiet single-limb balance and electromyographic activation onset of lower limb muscles

    Directory of Open Access Journals (Sweden)

    Papadakis Stamatios A

    2007-09-01

    Full Text Available Abstract Background Several studies have been carried out in order to investigate the effect of ankle bracing on ankle joint function and performance. However, no study so far has examined the role of skin-brace interface pressure in neuromuscular control. The aim of this study was to investigate the effect of different skin-ankle brace interface pressures on quiet single limb balance and the electromyographic (EMG activation sequence of four lower limb muscles. Methods Thirty three male physical education students who volunteered to take part in the study were measured under three ankle brace conditions: i without brace, ii with brace and 30 kPa application pressure and iii with brace and 60 kPa application pressure. Single limb balance (anteroposterior and mediolateral parameter was assessed on the dominant lower limb, with open and closed eyes, on a force platform, simultaneously with the EMG recording of four lower lower limb muscles' (gastrocnemius, peroneus longus, rectus femoris and biceps femoris activation onset. Results The results showed that overall balance (total stability parameter was not significantly affected in any of the three ankle brace conditions. However, the anteroposterior centre of pressure excursion and centre of pressure excursion velocity were significantly increased with the application of ankle brace, both with 30 and 60 kPa application pressures. Furthermore, it was found that single limb balance was significantly worse with closed eyes compared to open eyes. EMG measurements showed that the sequence of lower limb activation onset was not affected in any of the three ankle brace application conditions. The results of this study showed that the application of an ankle brace with two different skin-brace interface pressures had no effect on overall single limb balance and the sequence of lower limb muscle activation. Conclusion These findings suggest that peripheral joint receptors are either not adequately

  17. Lidocaine for preventing postoperative sore throat.

    Science.gov (United States)

    Tanaka, Yuu; Nakayama, Takeo; Nishimori, Mina; Tsujimura, Yuka; Kawaguchi, Masahiko; Sato, Yuki

    2015-07-14

    Sore throat is a common side-effect of general anaesthesia and is reported by between 30% and 70% of patients after tracheal intubation. The likelihood of a sore throat varies with the type, diameter, and cuff pressure of the endotracheal tube used. If intubation is essential, it may be helpful to give drugs prophylactically to alleviate postoperative sore throat. Local anaesthetics and steroids have been used for this purpose. This review was originally published in 2009 and was updated in 2015. The objective of this review was to evaluate the efficacy and any harm caused by topical and systemic lidocaine used prophylactically to prevent postoperative sore throat in adults undergoing general anaesthesia with endotracheal intubation. We searched CENTRAL (The Cochrane Library 2013, Issue 9), MEDLINE (January 1966 to October 2013), and EMBASE (1980 to October 2013). We also contacted manufacturers and researchers in the field. The original search was undertaken in June 2007. We reran the search in February 2015 and found four studies of interest. We will deal with those studies when we next update the review. We included randomized controlled trials (RCTs) of topical and systemic prophylactic lidocaine therapy versus control (using air or saline) that reported on the risk and severity of postoperative sore throat as an outcome. Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information, such as the risk of any adverse effects. We included 19 studies involving 1940 participants in this updated review. Of those 1940 participants, 952 received topical or systemic lidocaine therapy and 795 were allocated to the control groups. Topical and systemic lidocaine therapy appeared to reduce the risk of postoperative sore throat (16 studies, 1774 participants, risk ratio (RR) was 0.64 (95% confidence interval (CI) 0.48 to 0.85), the quality of the evidence was low), although when only high-quality trials were

  18. The efficacy of ketamine gargles on postoperative sore throat

    OpenAIRE

    Maryam Hadavi; Mohsen Rezaeian

    2011-01-01

    Background: Sore throat is one of the major post-operative complications. Despite efforts to reduce sore throat, this complication is still one of the main problems after surgery. The aim of this study was to analyze the effectiveness of ketamine gargle on sore throat after tracheal intubation.Materials and method: This double blind clinical trial was performed on 120, ASA-I and II, patients undergoing elective surgery for herniorrhaphy under general anesthesia. Patients in group 1 were gargl...

  19. 健康成人延迟性肌肉酸痛31P-MR波谱及其与肌酸激酶、酸痛指数相关性分析%The changes of healthy adults delayed onset muscle soreness 31P-MR spectroscopy and correlation between serum creatine kinase and soreness index

    Institute of Scientific and Technical Information of China (English)

    王希海; 陈超; 卢昊宁; 孟帆; 李飞; 王子文; 富聪聪; 夏丽莹; 富西湖

    2014-01-01

    目的 分析健康志愿者股四头肌延迟性肌肉酸痛(DOMS)31P-MRS影像特征,及其与肌酸激酶(CK)、酸痛指数相关性.方法 选取10名健康志愿者.所有受试者运用短距离重复跑运动模式进行训练以获得DOMS模型,且在运动前,运动后即刻、1、2、3、5、7d对右侧股四头肌进行31 P-MRS扫描、血清学CK浓度检查、肌肉酸痛指数评分,分别测量31P-MRS无机磷酸盐(Pi)、磷酸肌酸(PCr)和三磷酸腺苷(ATP)峰下面积,并计算Pi/PCr、PCr/ATP、Pi/ATP比值.运用重复测量资料的方差分析对各指标不同时间上的变化的特点进行分析.用Spearman秩相关分析对31P-MRS测量结果与CK值、酸痛指数进行相关性分析.结果 10名健康志愿者右侧股四头肌31P-MRS检查显示Pi峰下面积、Pi/PCr在运动后随时间逐渐增加,在运动后1~2 d达到最大值(分别为0.33 ±0.04、0.27±0.03),两者在时间上有一致性.PCr及ATP峰下面积在运动后即刻较运动前明显下降,在运动后1d逐渐恢复到运动前水平(分别为0.28±0.05、1.22 ±0.04).CK在运动后即刻轻度增高,运动后1d血清中CK[(577±223) U/L]明显增高达到峰值,运动后2 d[(483 ±229) U/L]逐渐下降但仍明显高于运动前水平[(86±30) U/L],运动后7dCK逐渐恢复到运动前水平.Pi峰下面积及Pi/PCr与CK均呈正相关(r值分别为0.631、0.614,P值均<0.01).PCr峰下面积、ATP峰下面积与CK值无相关性(r值分别为0.044、0.188,P值均>0.05).Pi峰下面积、Pi/PCr、Pi/ATP与酸痛指数相呈正相关(r值分别为0.762、0.758,0.616,P值均<0.05).结论 31P-MRS能够有效评估DOMS后骨骼肌代谢产物的变化规律,31P-MRS与血清学指标、肌肉酸痛指数能够对DOMS进行综合评价,十分有助于为运动训练提供科学的理论依据和指导.

  20. The efficacy of ketamine gargles on postoperative sore throat

    Directory of Open Access Journals (Sweden)

    Maryam Hadavi

    2011-10-01

    Full Text Available Background: Sore throat is one of the major post-operative complications. Despite efforts to reduce sore throat, this complication is still one of the main problems after surgery. The aim of this study was to analyze the effectiveness of ketamine gargle on sore throat after tracheal intubation.Materials and method: This double blind clinical trial was performed on 120, ASA-I and II, patients undergoing elective surgery for herniorrhaphy under general anesthesia. Patients in group 1 were gargled 40 mg ketamine in 30mg saline and in group 2, only 30ml saline. For third group we did not do any intervention. Postoperative sore throat was graded at 0, 2, 4 and 24 h after operation on Verbal Analogue Scale (0-4.Results: Postoperative sore throat occurred less frequently in group 1, when compared with groups 2 and 3, but the difference was not significant. Frequently sore throat was reported at two hours after surgery. In this study, there was no severe (score 3 or very severe (score 4 sore throat. No systemic or local side effects were observed. Conclusion: In this study, ketamine gargle reduced the incidence and severity of post-operative sore throat. Therefore, gargling of ketamine solution is recommended for cases that need to tracheal intubation, especially when the probability of difficult intubation and post-operative sore throat is high

  1. The ′reading man flap′ for pressure sore reconstruction

    Directory of Open Access Journals (Sweden)

    Stamatis Sapountzis

    2011-01-01

    Full Text Available Background: The treatment of pressure sores represents a significant challenge to health care professionals. Although, pressure wound management demands a multidisciplinary approach, soft tissue defects requiring reconstruction are often considered for surgical management. Myocutaneous and fasciocutaneous flaps can provide stable coverage of pressure sores. Purpose: Here, we describe our experience using a recent fasciocutaneous flap, which is named ′reading man′ flap, in sacral, ischial, and trochanteric pressure sores. Materials and Methods: During a period of 1 year the authors operated 16 patients, 11 men, and 5 women, using the reading man flap. The ages of the patients ranged from 24 to 78 years. The location of pressure sores was 8 sacral, 5 ischial, and 3 trochanteric pressure sores. The mean size of pressure sores was 8 cm × 9 cm. Results: All pressure sores covered bt the Reading Man flap healed asymptomatically. After follow-up of 2-8 months, no recurrences were encountered and no further surgical intervention was required. Conclusion: The reading man flap was found to be a useful technique for the closure of pressure sore in different anatomic locations. The advantage of tension-free closure and the minimal additional healthy skin excision made this flap a useful tool in pressure sore reconstructions.

  2. The 'reading man flap' for pressure sore reconstruction.

    Science.gov (United States)

    Sapountzis, Stamatis; Park, Hyoung Joon; Kim, Ji Hoon; Chantes, Achilleas; Beak, Rong Min; Heo, Chan Yeong

    2011-09-01

    The treatment of pressure sores represents a significant challenge to health care professionals. Although, pressure wound management demands a multidisciplinary approach, soft tissue defects requiring reconstruction are often considered for surgical management. Myocutaneous and fasciocutaneous flaps can provide stable coverage of pressure sores. Here, we describe our experience using a recent fasciocutaneous flap, which is named 'reading man' flap, in sacral, ischial, and trochanteric pressure sores. During a period of 1 year the authors operated 16 patients, 11 men, and 5 women, using the reading man flap. The ages of the patients ranged from 24 to 78 years. The location of pressure sores was 8 sacral, 5 ischial, and 3 trochanteric pressure sores. The mean size of pressure sores was 8 cm × 9 cm. All pressure sores covered bt the Reading Man flap healed asymptomatically. After follow-up of 2-8 months, no recurrences were encountered and no further surgical intervention was required. The reading man flap was found to be a useful technique for the closure of pressure sore in different anatomic locations. The advantage of tension-free closure and the minimal additional healthy skin excision made this flap a useful tool in pressure sore reconstructions.

  3. The ‘reading man flap’ for pressure sore reconstruction

    Science.gov (United States)

    Sapountzis, Stamatis; Park, Hyoung Joon; Kim, Ji Hoon; Chantes, Achilleas; Beak, Rong Min; Heo, Chan Yeong

    2011-01-01

    Background: The treatment of pressure sores represents a significant challenge to health care professionals. Although, pressure wound management demands a multidisciplinary approach, soft tissue defects requiring reconstruction are often considered for surgical management. Myocutaneous and fasciocutaneous flaps can provide stable coverage of pressure sores. Purpose: Here, we describe our experience using a recent fasciocutaneous flap, which is named ‘reading man’ flap, in sacral, ischial, and trochanteric pressure sores. Materials and Methods: During a period of 1 year the authors operated 16 patients, 11 men, and 5 women, using the reading man flap. The ages of the patients ranged from 24 to 78 years. The location of pressure sores was 8 sacral, 5 ischial, and 3 trochanteric pressure sores. The mean size of pressure sores was 8 cm × 9 cm. Results: All pressure sores covered bt the Reading Man flap healed asymptomatically. After follow-up of 2-8 months, no recurrences were encountered and no further surgical intervention was required. Conclusion: The reading man flap was found to be a useful technique for the closure of pressure sore in different anatomic locations. The advantage of tension-free closure and the minimal additional healthy skin excision made this flap a useful tool in pressure sore reconstructions. PMID:22279278

  4. Pressure sore prevention in hospital patients: a clinical audit.

    Science.gov (United States)

    Grewal, P S; Sawant, N H; Deaney, C N; Gibson, K M; Gupta, A M; Haverty, P F; Panditaratne, H G; Samarasinghe, S R; Sharma, A; Singh, S; Turner, S A; Wilkinson, S L; Wood, S P; Glickman, S

    1999-03-01

    Pressure sores cause significant mortality and morbidity as well as being a financial burden on health-care services. Reduction of pressure sore incidence is a Department of Health priority. Pressure sores are accepted as largely preventable complications of illness and disability and the means to achieve prevention are available. The aim of this clinical audit was to identify potential contributing factors to pressure sore acquisition in an acute hospital setting. The results suggest that substantial changes in the approach to clinical management may be needed.

  5. Effect of Caffeine on Perceived Soreness and Functionality Following an Endurance Cycling Event.

    Science.gov (United States)

    Caldwell, Aaron R; Tucker, Matthew A; Butts, Cory L; McDermott, Brendon P; Vingren, Jakob L; Kunces, Laura J; Lee, Elaine C; Munoz, Colleen X; Williamson, Keith H; Armstrong, Lawrence E; Ganio, Matthew S

    2017-03-01

    Caldwell, AR, Tucker, MA, Butts, CL, McDermott, BP, Vingren, JL, Kunces, LJ, Lee, EC, Munoz, CX, Williamson, KH, Armstrong, LE, and Ganio, MS. Effect of caffeine on perceived soreness and functionality following an endurance cycling event. J Strength Cond Res 31(3): 638-643, 2017-Caffeine can reduce muscle pain during exercise; however, the efficacy of caffeine in improving muscle soreness and recovery from a demanding long-duration exercise bout has not been established. The purpose of this study was to investigate the effects of caffeine intake on ratings of perceived muscle soreness (RPMS) and perceived lower extremity functionality (LEF) following the completion of a 164-km endurance cycling event. Before and after cycling RPMS (1-to-6; 6 = severe soreness) and LEF (0-to-80; 80 = full functionality) were assessed by questionnaires. Subjects ingested 3 mg/kg body mass of caffeine or placebo pills in a randomized, double-blind fashion immediately after the ride and for the next 4 mornings (i.e., ∼800 hours) and 3 afternoons (i.e., ∼1200 hours). Before each ingestion, RPMS and LEF were assessed. Afternoon ratings of LEF were greater with caffeine ingestion the first day postride (65.0 ± 6.1 vs. 72.3 ± 6.7; for placebo and caffeine, respectively; p = 0.04), but at no other time points (p > 0.05). The caffeine group tended to have lower overall RPMS in the afternoon versus placebo (i.e., main effect of group; 1.1 ± 0.2 vs. 0.5 ± 0.2; p = 0.09). Afternoon RPMS for the legs was significantly lower in the caffeine group (main effect of caffeine; 1.3 ± 0.2 vs. 0.5 ± 0.3; p = 0.05). In conclusion, ingesting caffeine improved RPMS for the legs, but not LEF in the days following an endurance cycling event. Athletes may benefit from ingesting caffeine in the days following an arduous exercise bout to relieve feelings of soreness and reduced functionality.

  6. Pressure sores and pressure sore prevention in a rehabilitation setting: building information for improving outcomes and allocating resources.

    Science.gov (United States)

    Baggerly, J; DiBlasi, M

    1996-01-01

    Quantifiable information regarding pressure sore prevention and management is a prerequisite for program development, outcome evaluation, and resource allocation. In this study, all patients admitted to an acute rehabilitation setting (N = 446) during a 2-month period were assessed for the presence of a pressure sore, the risk for developing a pressure sore, the rate of agreement between "objective" (Braden scale) and "subjective" (standard nursing admission data) measures of risk and outcome, and the status of pressure sores at discharge. This article provides the details of the project and implications for rehabilitation nursing practice.

  7. Changes in neutrophil count, creatine kinase and muscle soreness ...

    African Journals Online (AJOL)

    Department of Sport, Rehabilitation and Dental Sciences. Tshwane University ... screening in the Exercise Testing Laboratory (ETL). During the first visit .... blood analyser, which uses a colorometric assay procedure. (Boehringer ... Significance was set at p<0.05. ..... the entire period (before exercise through 144 h after). As.

  8. Effects of intravenous diclofenac on postoperative sore throat in ...

    African Journals Online (AJOL)

    EB

    patients undergoing laparoscopic surgery at Aga Khan University ... Background: postoperative sore throat is the commonest complication after ... Data of the baseline characteristics, the incidence and severity of sore throat ..... applied to the anterior aspect of the neck, Ozaki et ... Nordin U, Lindholm C E, Wolgast M. Blood.

  9. Prevention of pressure sores by identifying patients at risk

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Jensen, O; Kvorning, S A

    1982-01-01

    The risk of pressure sores developing in patients admitted with acute conditions was assessed by a simple risk score system based on age, reduced mobility, incontinence, pronounced emaciation, redness over bony prominences, unconsciousness, dehydration, and paralysis in a prospective clinical study...... of pressure sores prevents their development....

  10. Pressure sores in spinal cord injury: Active intervention saves costs

    African Journals Online (AJOL)

    2008-07-22

    Jul 22, 2008 ... 33% incidence in the acute management phase.1. This high ... noted.2 Pressure sores not only pose a significant risk to the patient, but ... medical/nursing staff education on pressure sore incidence, extended stay and associated costs. Results. ... employed via a private nursing agency to address the.

  11. Prevention of pressure sores by identifying patients at risk

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Jensen, O; Kvorning, S A

    1982-01-01

    The risk of pressure sores developing in patients admitted with acute conditions was assessed by a simple risk score system based on age, reduced mobility, incontinence, pronounced emaciation, redness over bony prominences, unconsciousness, dehydration, and paralysis in a prospective clinical study...... of pressure sores prevents their development....

  12. New concepts in the prevention of pressure sores.

    Science.gov (United States)

    Bogie, Kath; Powell, Heather L; Ho, Chester H

    2012-01-01

    Pressure sores are a serious, and costly, complication for many patients with reduced mobility and sensation. Some populations, such as those with spinal cord injury (SCI), remain at high risk throughout their lifetime. Prevention is highly preferable and while the concept is readily definable, it is much more challenging to develop valid preventative measures. Subjective and objective approaches to risk factor assessment before pressure sores develop are reviewed, including risk status scales and emerging techniques to assess deep tissue injury. Devices to prevent pressure sores have traditionally focused on pressure-relieving cushions and mattresses. Technological advances being applied in the development of new pressure sore prevention devices are presented. Clinical evidence-based practice is integral to pressure sore prevention. Comprehensive assessment must include evaluation of systemic diseases, anatomical and physiological factors, together with environmental and psychosocial factors, which can all contribute to pressure sore development. Extrinsic factors need to be considered in conjunction with intrinsic tissue health factors and are reviewed together with an evaluation of currently available clinical practice guidelines. This chapter presents the broad diversity of factors associated with pressure sore development and highlights the need for an interdisciplinary team approach in order to maximize successful prevention of pressure sores. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Efficiency of Magnetic Field Treatment on Pressure Sores in Bedridden Patients

    Directory of Open Access Journals (Sweden)

    Ferda Özdemir

    2011-09-01

    Full Text Available Objective: Pressure sores are an important source of complications in patients who are immobilized and bedridden. We aimed to investigate the efficiency of magnetic field treatment in pressure sores. Material and Methods: This was a randomized, double blind controlled design study. 20 patients in the study group received magneto-therapy, once a day for 30 minutes and with 150G, keeping to the BTL09 magnetotherapy device’s program. In the control group, 20 patients received the dressing only once a day. The surface areas of the pressure sores were evaluated at the onset of the treatment (1st day, and on the 7th and 15th days.Results: When within group comparisons were conducted, a significant difference was observed between the 1st and 7th day, 7th and 15th day, and 1st and 15th day measures in both the groups in terms of the scar area. The average healing time for the treatment group was 10.80±4.06 (6-20 days, and the average healing time for the control group was 18.85±9.75 (5-32 days. There was a statistically significant difference between the two groups (z=-2.114, p=0.034. Also, there was a significant difference in the scar area between the two groups in the 15th day measure (z=-3.818, p=0.000.Conclusion: The healing process of the tissue can be accelerated.with the use of magnetotherapy in the treatment of pressure sores of stage II and III,

  14. Effect of L-Glutamine Supplementation on Electromyographic Activity of the Quadriceps Muscle Injured By Eccentric Exercise

    Directory of Open Access Journals (Sweden)

    Farhad Rahmani Nia

    2013-06-01

    Full Text Available   Objective(s: The purpose of the present study was to examine the effects of L-glutamine on electromyographic (EMG activity of the quadriceps muscle injured by eccentric exercise (EE.   Materials and Methods: Seventeen healthy men (age: 22.35±2.27 yr; body mass: 69.91±9.78 kg; height: 177.08±4.32 cm were randomly and double-blind study with subjects assigned to either an L-glutamine supplementation (n=9 or placebo (n=8 group. The subjects in two groups were asked to take three times during a week for 4 weeks. Each subject was screened for dietary habits before inclusion into the study. Participants performed 6 set to exhaustion eccentric leg extensions at 75% of 1RM and rest intervals were 3 min among sets. Pain Assessment Scale (PAS, EMG activity and range of motion (ROM measurements were taken before exercise protocol and 24 and 48 hr afterwards. Results: There was no statistically significant difference between groups in perceived muscle soreness (SOR, ROM and EMG activity (P < 0.05. Conclusion: The results indicate that L-glutamine supplementation has no significant effect on muscle injury markers in between groups, although glutamine supplementation attenuated delayed onset muscle soreness (DOMS effects in sup group.

  15. New-onset heart failure due to heart muscle disease in childhood: a prospective study in the United kingdom and Ireland.

    Science.gov (United States)

    Andrews, Rachel E; Fenton, Matthew J; Ridout, Deborah A; Burch, Michael

    2008-01-01

    We undertook the first prospective, national, multicenter study to describe the incidence and outcome of heart muscle disease-induced heart failure in children. Data were collected on patients admitted to a hospital through 2003 with a first episode of heart failure in the absence of congenital heart disease. All 17 pediatric cardiac centers in the United Kingdom and Ireland participated. Follow-up data were obtained to a minimum of 1 year. The incidence was 0.87/100,000 population Heart Association class III to IV. Causes of heart failure included dilated cardiomyopathy (50 idiopathic, 8 familial), probable myocarditis (23), occult arrhythmia (7), anthracycline toxicity (5), metabolic disease (4), left ventricular noncompaction (3), and other (4). Overall 1-year survival was 82%, and event (death or transplantation)-free survival was 66%. Regression analysis showed older age and reduced systolic function on admission echocardiogram increased the event risk. Only 8% of event-free survivors (n=69) remained in New York Heart Association class III to IV, but 35 required readmission during the study period, and all but 8 remained on medication. This first national prospective study of new-onset heart failure in children has shown an incidence of 0.87/100,000. Multivariable analysis of survival data indicates a better outcome for younger children and for those with better systolic function at presentation, but overall, one third of children die or require transplantation within 1 year of presentation.

  16. Tissue electrical properties monitoring for the prevention of pressure sore.

    Science.gov (United States)

    Ching, Congo Tak-Shing; Chou, Mei-Yun; Jiang, Siou-Jhen; Huang, Su-Hua; Sun, Tai-Ping; Liu, Wei-Hao; Liu, Chia-Ming

    2011-12-01

    Pressure sores are a significant problem in the healthcare sector. Although they may cause considerable morbidity, they are preventable. The objectives of this study are to (1) investigate the electrical properties of a tissue close to and away from the pressure sore site, and (2) establish a new approach for objective, reliable, low-cost and noninvasive screening or detection of pressure sore in its early stage. Randomised controlled trial. Fifteen patients participated in this study. They all had stage I or stage II sacral pressure sores. Tiny surface electrodes in four-electrode configuration were used for all tissue electrical properties measurements recorded over the frequency range of 30-10 MHz. Intraclass correlation coefficient (ICC) showed that all measurements (ICC > 0.90 for all measurements) had good reliability and validity. The real part of impedance (R) and the imaginary part of impedance (X) of a tissue measured close to the pressure sore site was found to be significantly smaller (p pressure sore site at a specific frequency range (R: 30.00-38.55 Hz; X: 43.95-606.40 Hz). It was also found that the extracellular resistance (R(e)) and the ratio of extracellular resistance to intracellular resistance (R(e)/R(i)) of a tissue measured close to the pressure sore site were significantly smaller (p pressure sore site. Since the electrical properties (R, X, R(e), R(e)/R(i) ) of a tissue close to, and away from, the pressure sore site can be significantly distinguished, a potentially promising method for the screening of pressure sores at an early stage has been proposed.

  17. The effect of temperature on eccentric contraction-induced isometric force loss in isolated perfused rat medial gastrocnemius muscle

    Directory of Open Access Journals (Sweden)

    Vasaghi Gharamaleki B

    2008-09-01

    Full Text Available "nBackground: The typical features of eccentric exercise-induced muscle damage are delayed-onset muscle soreness (DOMS and prolonged loss of muscle strength. It has been shown that passive warmth is effective in reducing muscle injury. Due to the interaction of different systems in vivo, we used isolated perfused medial gastrocnemius skeletal muscle to study the direct effect of temperature on the eccentric contraction-induced force loss. "nMethods: After femoral artery cannulation of a rat, the left medial gastrocnemius muscle was separated and then the entire lower limb was transferred into a prewarmed (35oC chamber. With the chamber temperature at 31, 35 and 39oC before and during eccentric contraction. Isometric force loss was measured after 15 eccentric contractions (N=7-9. "nResults: Maximum contraction force reduction has been used as an index for eccentric contraction-induced force loss. In this study eccentric contraction caused a significant reduction in maximum isometric tension (p<0.01, but no significant difference was seen in isometric force loss at 31oC and 39oC compared with that at 35oC. "nConclusions: Our results suggest that temperature changes before or during eccentric contractions have no effect on eccentric contraction-induced force loss. "nKeywords: Isolated perfused muscle, skeletal muscle, eccentric contractions, isometric force, gastrocnemius muscle, temperature.

  18. Muscle imaging data in late-onset Pompe disease reveal a correlation between the pre-existing degree of lipomatous muscle alterations and the efficacy of long-term enzyme replacement therapy

    Directory of Open Access Journals (Sweden)

    Kai Michael Gruhn

    2015-06-01

    Conclusions: The results demonstrate that fatty muscle degeneration can occur before clinical manifestation of muscle weakness and suggest that mildly affected muscles may respond better to ERT treatment than severely involved muscles. If these findings can be validated by further studies, it should be discussed if muscle alterations detected by muscle MRI may be an objective sign of disease manifestation justifying an early start of ERT in clinically asymptomatic patients in order to improve the long-term outcome.

  19. [Experience in the treatment of severe pressure sore].

    Science.gov (United States)

    Xu, Xi-Sheng; ma, Zheng-Zheng; Zhou, Yong-Sheng; Ou, Cai-Sheng; Cheng, Yong; Chen, Kai; Li, Bo-Tong; Zhou, Hai-Yang; Hu, Yong-Cai

    2011-11-01

    To summarize the experience in the treatment of severe pressure sore. From Aug. 2007 to Jun. 2011, 21 cases of severe pressure sore with 43 III-IV degree lesions were treated with combination treatment, including vacuum sealing drainage technique, local fascia flaps, upper or lower gluteus maximus island myocutaneous flaps, lower gluteus maximus myocutaneous flap, neurocutaneous femoris posterior flaps, tensor fascia lata island myocutaneous flaps, free latissimus dorsi myocutaneous flaps, and skin graft, combined with stryker frame and nursing tracking guidance. 13 of 21 cases had multiple pressure sore. Among them, 5 III degree pressure sores were covered by skin grafting and 3 non-caudal III degree pressure sores (pressure sore. All the 43 wounds healed completely. 5 wounds in 3 cases had effusion under flap which healed after re-drainage. The wounds were not healed in 3 cases with flap transposition which were also healed after re-debridement. All the flaps survived completely. 16 cases were followed up for 2-26 months. Recurrence happened in 4 cases after discharge because of not following the required nursing care. Comprehensive application of vacuum sealing drainage technique, multiple myocutaneous flaps and skin grafting, combined with stryker frame and nursing tracking guidance after discharge can be used for the treatment of severe pressure sore with satisfactory results.

  20. Can electric beds aid pressure sore prevention in hospitals?

    Science.gov (United States)

    Hampton, S

    The purchase, cleaning and maintenance of air mattresses can be an expensive part of pressure sore prevention and repositioning of patients can be time consuming and costly in terms of possible nursing injuries. The King's Fund bed has been a friend to the health service for many years but the time has come to look for an alternative system that will support patient comfort and independence, will assist nurses in implementation of a no-lifting policy and aid pressure sore prevention policies. This article describes a study that was undertaken in two medical wards to assess the value of electrically controlled beds in relation to the prevention of pressure sores, implementation of a no-lifting policy and quality of patient care. A total of 782 patients took part in the study over a 6-month period and 726 replies were obtained from nurses. The ward had similar profiles of patients' medical conditions and age; they were being medically managed by the same consultants. Results showed that patients experienced greater comfort on beds with the electric facility, produced less pressure sores, mobilized easily and pressure sore prevention costs could be reduced. There is a need to be proactive in prevention of pressure sores and not reactive to a pressure sore that is already developing.

  1. Trunk, abdomen, and pressure sore reconstruction.

    Science.gov (United States)

    Rubayi, Salah; Chandrasekhar, Bala S

    2011-09-01

    After reading this article, the participant should be able to: 1. Describe the principles of wound closure, torso reconstruction, and pressure sore reconstruction. 2. Outline standard options to treat defects of the chest, abdomen, and back and pressure ulcers in all anatomical areas. 3. Manage and prevent pressure ulcers. Chest wall reconstruction is indicated following tumor resection, radiation wound breakdown, or intrathoracic sepsis. Principles of wound closure and chest wall stabilization, where indicated, are discussed. Principles of abdominal wall reconstruction continue to evolve with the introduction of newer bioprosthetics and the application of functional concepts for wound closure. The authors illustrate these principles using commonly encountered clinical scenarios and guidelines to achieve predictable results. Pressure ulcers continue to be devastating complications to patients' health and a functional hazard when they occur in the bedridden, in patients with spinal cord injuries, and in patients with neuromuscular disease. Management of pressure ulcers is also very expensive. The authors describe standard options to treat defects of the chest, abdomen, and back and pressure ulcers in all anatomical areas. A comprehensive understanding of principles and techniques will allow practitioners to approach difficult issues of torso reconstruction and pressure sores with a rational confidence and an expectation of generally satisfactory outcomes. With pressure ulcers, prevention remains the primary goal. Patient education and compliance coupled with a multidisciplinary team approach can reduce their occurrence significantly. Surgical management includes appropriate patient selection, adequate débridement, soft-tissue coverage, and use of flaps that will not limit future reconstructions if needed. Postoperatively, a strict protocol should be adapted to ensure the success of the flap procedure. Several myocutaneous flaps commonly used for the surgical

  2. Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing.

    Science.gov (United States)

    Baumert, Philipp; Lake, Mark J; Stewart, Claire E; Drust, Barry; Erskine, Robert M

    2016-09-01

    Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can result in ultrastructural muscle disruption, impaired excitation-contraction coupling, inflammation and muscle protein degradation. This process is associated with delayed onset muscle soreness and is referred to as exercise-induced muscle damage. Although a certain amount of muscle damage may be necessary for adaptation to occur, excessive damage or inadequate recovery from exercise-induced muscle damage can increase injury risk, particularly in older individuals, who experience more damage and require longer to recover from muscle damaging exercise than younger adults. Furthermore, it is apparent that inter-individual variation exists in the response to exercise-induced muscle damage, and there is evidence that genetic variability may play a key role. Although this area of research is in its infancy, certain gene variations, or polymorphisms have been associated with exercise-induced muscle damage (i.e. individuals with certain genotypes experience greater muscle damage, and require longer recovery, following strenuous exercise). These polymorphisms include ACTN3 (R577X, rs1815739), TNF (-308 G>A, rs1800629), IL6 (-174 G>C, rs1800795), and IGF2 (ApaI, 17200 G>A, rs680). Knowing how someone is likely to respond to a particular type of exercise could help coaches/practitioners individualise the exercise training of their athletes/patients, thus maximising recovery and adaptation, while reducing overload-associated injury risk. The purpose of this review is to provide a critical analysis of the literature concerning gene polymorphisms associated with exercise-induced muscle damage, both in young and older individuals, and to highlight the potential mechanisms underpinning these associations, thus providing a better understanding of exercise-induced muscle damage.

  3. Sciatica caused by pyomyositis of the piriformis muscle in a pediatric patient.

    Science.gov (United States)

    Toda, Taihei; Koda, Masao; Rokkaku, Tomoyuki; Watanabe, Hitoshi; Nakajima, Arata; Yamada, Toshiyuki; Murakami, Ken-ichi; Nakajima, Hideyuki; Murakami, Masazumi

    2013-02-01

    Because the sciatic nerve leaves the pelvis through the greater sciatic notch underneath the piriformis muscle, any pathology of the piriformis muscle could result in entrapment of the sciatic nerve; this is widely known as piriformis muscle syndrome. Pyomyositis of the piriformis muscle may be a cause of piriformis muscle syndrome. Piriformis muscle syndrome caused by pyomyositis of the piriformis muscle in pediatric patients is rare. This article describes a case of sciatica caused by pyomyositis of the piriformis muscle in a pediatric patient. A 6-year-old boy presented with right buttock and thigh pain following a mild fever and sore throat. The pain worsened, and he became unable to walk. On admission, his temperature was 38.4°C. He reported severe right-sided buttock and lateral thigh pain. Positive Freiberg sign was observed. Laboratory examination revealed elevated white blood cell count and C-reactive protein level. T2-weighted magnetic resonance images of the pelvis revealed high-intensity changes of the piriformis muscle and iliosacral joint. Thus, piriformis syndrome caused by pyomyositis of the piriformis muscle was diagnosed. Oral antibiotics (10 mg/kg per day of cefdinir) were administered. Pain gradually decreased, and the patient was able to walk. Final follow-up examination at 6 months after symptom onset revealed no sciatic pain. Follow-up magnetic resonance imaging revealed normalized intensities of the piriformis muscle. The endopelvic fascia provides a route for infection from the pelvis to the piriformis. The pyomyositis of the piriformis muscle in the current case may have occurred secondary to the pyoarthritis of the sacroiliac joint. Endopelvic infections involving the piriformis muscle may mimic hip diseases in pediatric patients.

  4. Re-evaluation of sarcolemma injury and muscle swelling in human skeletal muscles after eccentric exercise.

    Science.gov (United States)

    Yu, Ji-Guo; Liu, Jing-Xia; Carlsson, Lena; Thornell, Lars-Eric; Stål, Per S

    2013-01-01

    The results regarding the effects of unaccustomed eccentric exercise on muscle tissue are often conflicting and the aetiology of delayed onset muscle soreness (DOMS) induced by eccentric exercise is still unclear. This study aimed to re-evaluate the paradigm of muscular alterations with regard to muscle sarcolemma integrity and fibre swelling in human muscles after voluntary eccentric exercise leading to DOMS. Ten young males performed eccentric exercise by downstairs running. Biopsies from the soleus muscle were obtained from 6 non-exercising controls, 4 exercised subjects within 1 hour and 6 exercised subjects at 2-3 days and 7-8 days after the exercise. Muscle fibre sarcolemma integrity, infiltration of inflammatory cells and changes in fibre size and fibre phenotype composition as well as capillary supply were examined with specific antibodies using enzyme histochemistry and immunohistochemistry. Although all exercised subjects experienced DOMS which peaked between 1.5 to 2.5 days post exercise, no significant sarcolemma injury or inflammation was detected in any post exercise group. The results do not support the prevailing hypothesis that eccentric exercise causes an initial sarcolemma injury which leads to subsequent inflammation after eccentric exercise. The fibre size was 24% larger at 7-8 days than at 2-3 days post exercise (pexercise (lower in 5 of the 6 subjects at 7-8 days than at 2-3 days; pexercise was interpreted to reflect fibre swelling. Because the fibre swelling did not appear at the time that DOMS peaked (between 1.5 to 2.5 days post exercise), we concluded that fibre swelling in the soleus muscle is not directly associated with the symptom of DOMS.

  5. Regulation mechanism of uterine smooth muscle and labor onset%子宫平滑肌收缩调控机制与分娩启动

    Institute of Scientific and Technical Information of China (English)

    李乐赛; 周昌菊

    2011-01-01

    分娩启动是子宫由相对静止进入活跃状态的复杂过程,子宫平滑肌是其效应的靶器官,但其收缩机制尚未完全阐明,因而限制了临床处理及相关药物的开发.该文从子宫平滑肌细胞内收缩相关装置、经典电生理机制、细胞内的信号转导、钙敏感性理论、分娩启动相关膜蛋白的功能及变化等方面作以综述,以期了解调节子宫平滑肌收缩可能的分子机理,从而完善对妊娠子宫正常生理过程和常见病理状态的整体认识,也有助于对分娩、早产、产后出血等临床事件的预测和处理.%Onset of labor is a complex process of myometrial activation fiom quiescent pregnant state to active contractile state. The uterine smooth muscle plays an important role in this process, but the mechanism by which contraction is regulated is not fully clear so far.The goal of this review is to provide an overview of the molecular mechanism by which uterine contractility might be regulated, including the contractile apparatus, electrophysiology of uterine nyocytes, mechanism of calcium sensitization, contraction-associated proteins etc., thus provides better understanding of parturition, preterm labor and postpartum hemorrhage.

  6. Benefits of dietary phytochemical supplementation on eccentric exercise-induced muscle damage: Is including antioxidants enough?

    Science.gov (United States)

    Pereira Panza, Vilma Simões; Diefenthaeler, Fernando; da Silva, Edson Luiz

    2015-09-01

    The purpose of this review was to critically discuss studies that investigated the effects of supplementation with dietary antioxidant phytochemicals on recovery from eccentric exercise-induced muscle damage. The performance of physical activities that involve unaccustomed eccentric muscle actions-such as lowering a weight or downhill walking-can result in muscle damage, oxidative stress, and inflammation. These events may be accompanied by muscle weakness and delayed-onset muscle soreness. According to the current evidences, supplementation with dietary antioxidant phytochemicals appears to have the potential to attenuate symptoms associated with eccentric exercise-induced muscle damage. However, there are inconsistencies regarding the relationship between muscle damage and blood markers of oxidative stress and inflammation. Furthermore, the effectiveness of strategies appear to depend on a number of aspects inherent to phytochemical compounds as well as its food matrix. Methodological issues also may interfere with the proper interpretation of supplementation effects. Thus, the study may contribute to updating professionals involved in sport nutrition as well as highlighting the interest of scientists in new perspectives that can widen dietary strategies applied to training. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Shortening and intracellular Ca2+ in ventricular myocytes and expression of genes encoding cardiac muscle proteins in early onset type 2 diabetic Goto-Kakizaki rats.

    Science.gov (United States)

    Salem, K A; Adrian, T E; Qureshi, M A; Parekh, K; Oz, M; Howarth, F C

    2012-12-01

    There has been a spectacular rise in the global prevalence of type 2 diabetes mellitus. Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. Contractile dysfunction, associated with disturbances in excitation-contraction coupling, has been widely demonstrated in the diabetic heart. The aim of this study was to investigate the pattern of cardiac muscle genes that are involved in the process of excitation-contraction coupling in the hearts of early onset (8-10 weeks of age) type 2 diabetic Goto-Kakizaki (GK) rats. Gene expression was assessed in ventricular muscle with real-time RT-PCR; shortening and intracellular Ca(2+) were measured in ventricular myocytes with video edge detection and fluorescence photometry, respectively. The general characteristics of the GK rats included elevated fasting and non-fasting blood glucose and blood glucose at 120 min following a glucose challenge. Expression of genes encoding cardiac muscle proteins (Myh6/7, Mybpc3, Myl1/3, Actc1, Tnni3, Tnn2, Tpm1/2/4 and Dbi) and intercellular proteins (Gja1/4/5/7, Dsp and Cav1/3) were unaltered in GK ventricle compared with control ventricle. The expression of genes encoding some membrane pumps and exchange proteins was unaltered (Atp1a1/2, Atp1b1 and Slc8a1), whilst others were either upregulated (Atp1a3, relative expression 2.61 ± 0.69 versus 0.84 ± 0.23) or downregulated (Slc9a1, 0.62 ± 0.07 versus 1.08 ± 0.08) in GK ventricle compared with control ventricle. The expression of genes encoding some calcium (Cacna1c/1g, Cacna2d1/2d2 and Cacnb1/b2), sodium (Scn5a) and potassium channels (Kcna3/5, Kcnj3/5/8/11/12, Kchip2, Kcnab1, Kcnb1, Kcnd1/2/3, Kcne1/4, Kcnq1, Kcng2, Kcnh2, Kcnk3 and Kcnn2) were unaltered, whilst others were either upregulated (Cacna1h, 0.95 ± 0.16 versus 0.47 ± 0.09; Scn1b, 1.84 ± 0.16 versus 1.11 ± 0.11; and Hcn2, 1.55 ± 0.15 versus 1.03 ± 0.08) or downregulated (Hcn4, 0.16 ± 0.03 versus 0.37 ± 0.08; Kcna2, 0.35 ± 0

  8. Mouth Sores Caused by Cancer Treatment: How to Cope

    Science.gov (United States)

    Diseases and Conditions Cancer Understand how to manage cancer treatment side effects, including mouth sores, so you can feel more in control as you go through cancer treatment. By Mayo Clinic Staff If you're about ...

  9. GARGLING WITH KETAMINE ATTENUATES POST-OPERATIVE SORE THROAT

    National Research Council Canada - National Science Library

    Tejashwini; Jagadish

    2014-01-01

    : INTRODUCTION: Postoperative Sore Throat (POST) is a common complication that is unresolved in patients undergoing endotracheal intubation, which is the foremost cause of trauma to the air way mucosa...

  10. Can You Get Genital Herpes from a Cold Sore?

    Science.gov (United States)

    ... Lucy* Yes — it is possible to get genital herpes from oral sex. Genital herpes is caused by the herpes ... Genital herpes is usually caused by HSV-2; oral herpes (cold sores) is usually caused by HSV-1. ...

  11. An unusual pressure sore of the nasal bridge.

    Science.gov (United States)

    Sleilati, Fadi H; Stephan, Henri A; Nasr, Marwan W; Riachy, Moussa A

    2008-07-01

    We report an unusual pressure sore of the nasal bridge caused by a non-invasive ventilation mask. Conservative treatment was unsuccessful, and the defect had to be repaired, with a good postoperative result.

  12. Tracheal intubation and sore throat: a mechanical explanation.

    Science.gov (United States)

    Chandler, M

    2002-02-01

    Although tracheal intubation remains a valuable tool, it may result in pressure trauma and sore throat. The evidence for an association between these sequelae is not conclusive and sore throat may be caused at the time of intubation. This hypothesis was tested in a mechanical model and the results from tracheal intubation compared with those from insertion of a laryngeal mask airway, which is associated with a lower incidence of sore throat. Use of the model suggests that the tracheal tube and laryngeal mask airway impinge on the pharyngeal wall in different manners and involve different mechanisms for their conformation to the upper airway, but that in a static situation, the forces exerted on the pharyngeal wall are low with both devices. It also suggests that the incidence of sore throat should be lower for softer and smaller tracheal tubes and that the standard 'Magill' curve (radius of curvature 140 +/- 20 mm) is about optimum for the average airway.

  13. The effect of ketamine on sore throat after tonsillectomy

    OpenAIRE

    M. Haghighi; A Parvizi; H. Movahedi; S. Hadadi; Sh. Marzban

    2007-01-01

    AbstractBackground and purpose: Ketamine efficacy as an analgesic adjuvant has been studied in several clinical settings with conflicting results. Sore throat and pain after swallowing following tonsillectomy is significant. The aim of this study was to investigate the effect of ketamine on sore throat (pain) after tonsillectomy.Materials and Methods: In this double blind clinical trial, fifty children were, divided in to two equal groups of Ketamine and control. The subjects aged 4-14 years ...

  14. Magnesium and Ketamine Gargle and Postoperative Sore Throat

    OpenAIRE

    Teymourian, Houman; Mohajerani, Seyed Amir; Farahbod, Alireza

    2015-01-01

    Background: Postoperative sore throat is one of the most common complications after endotracheal intubation. Both Ketamine and magnesium can block N-methyl-D-aspartic acid (NMDA) receptors and provide central and local analgesia. Objectives: To compare the effect of magnesium sulfate and ketamine gargle on the incidence and severity of postoperative sore throat. Patients and Methods: A total of 100 patients candidate for emergency acute appendicitis surgery were enrolled in the study. Patient...

  15. Efeito do uso de meia elástica sobre os níveis dos biomarcadores de lesão muscular em atletas de voleibol após atividade física Effect of elastic stockings on biomarkers levels of muscle soreness in volleyball players after exercise

    Directory of Open Access Journals (Sweden)

    Marcondes Figueiredo

    2011-12-01

    Full Text Available OBJETIVO: Avaliar os níveis plasmáticos dos biomarcadores de lesão muscular, a saber, creatina quinase, lactato desidrogenase e mioglobina, em atletas profissionais de voleibol após exercícios musculares anaeróbicos, com e sem uso de meia elástica. MÉTODOS: Foram avaliadas dez jogadoras profissionais de voleibol, com idades entre 18 e 25 anos, utilizando ou não meia elástica (Sport Active®, Venosan, Abreu e Lima, Brasil, com compressão de 20 a 30 mmHg abaixo do joelho. As dosagens foram feitas em três momentos: M0, início da manhã, com as atletas em repouso sem uso de meia elástica; M1, início da manhã, após a realização de atividade física com uso de meia elástica; M2, sete dias depois, após a realização dos mesmos exercícios, porém sem uso de meia elástica. Aplicou-se a escala de Borg após cada série de atividade física para avaliação do esforço. RESULTADOS: Os valores médios obtidos para creatina quinase e lactato desidrogenase foram, respectivamente, de 117,7±40,2 e 134,2±11,3 U/L, em M0; 138,2±47,2 e 157,9±10,1 U/L, em M1; e 161,3±59,9 e 177,2±18,8 U/L, em M2. Os valores médios obtidos para mioglobina foram de 31,5±6,5; 34,9±5,6 e 38,6±12,6 µg/L nos momentos M0, M1 e M2, respectivamente. Houve diferenças estatisticamente significativas (Tukey entre M1 e M2 para os valores de creatina quinase (p=0,0007 e lactato desidrogenase (p=0,000, mas não para os valores de mioglobina (p=0,1135. Os escores da escala de Borg em M1 e M2 foram, respectivamente, de 17,8 e 18,2, sem diferença estatisticamente significante entre eles (Wilcoxon. CONCLUSÃO: O uso da meia elástica foi associado a menores níveis plasmáticos dos biomarcadores de lesão muscular após exercício físico.OBJECTIVE:To assess plasma levels of muscle soreness biomarkers, namely creatine kinase, lactate dehydrogenase, and myoglobin, in professional volleyball players following anaerobic exercise with and without the use of elastic

  16. Ketamine gargle for attenuating postoperative sore throat.

    Science.gov (United States)

    Canbay, O; Celebi, N; Sahin, A; Celiker, V; Ozgen, S; Aypar, U

    2008-04-01

    Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21-65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Forty-six, ASA I-II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (PKetamine gargle significantly reduced the incidence and severity of POST.

  17. Rehabilitation of muscle after injury - the role of anti-inflammatory drugs

    DEFF Research Database (Denmark)

    Mackey, Abigail; Mikkelsen, U R; Magnusson, S P

    2012-01-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) are widely consumed among athletes worldwide in relation to muscle injury and soreness. This review aims to provide an overview of studies investigating their effects on skeletal muscle, in particular the repair processes in injured muscle. Muscle in...

  18. [Six treatment principles of the basle pressure sore concept].

    Science.gov (United States)

    Rieger, U; Scheufler, O; Schmid, D; Zweifel-Schlatter, M; Kalbermatten, D; Pierer, G

    2007-06-01

    The treatment of pressure sores has gained importance due to the increase of geriatric patients and general life expectancy as well as improved therapeutic options in patients with spinal cord injuries. The aetiology of pressure sores is multifactorial. Risk factors such as immobility, malnutrition, and other co-morbidities have to be considered. Therapy of pressure sores is time- and cost-consuming and recurrence rates are high. Successful treatment is based on the interdisciplinary cooperation between conservative and surgical disciplines, nursing, as well as on continuous patient education. The Basle pressure sore concept consists of six principles. Over a total treatment period of approximately three months usually two operative interventions are performed. For effective relief of pressure (1st principle) patients are placed on low-airloss beds. Operative debridement of pressure sores is performed early and systemic or local infection is treated (2nd principle). The wound is then conditioned with moist dressings or VAC (3rd principle). Simultaneously concomitant malnutrition is quantified clinically and chemically and treated by oral or, if necessary, parenteral nutrition. Other risk factors are optimised as well as possible (4th principle). Hereby optimal conditions for plastic-surgical coverage are provided (5th principle). Postoperatively a standardised concept of pressure relief and mobilisation is adhered to (6th principle). This multimodal treatment concept is well established at the University Hospital of Basle for many years. Combined with an effective prevention, the rate of pressure sores could be significantly reduced, wounds could be healed, and the number of recurrences diminished. In a two-year period between January 2004 and December 2005 the Basle plastic surgery team treated 170 pressure sores in 142 patients according to this concept in the Swiss paraplegic centre in Nottwil. In 2006, 78 % of these patients (111 patients) were followed up and

  19. Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake

    DEFF Research Database (Denmark)

    Bangsbo, Jens; Gibala, Martin J.; Howarth, Krista R.

    2006-01-01

    It was proposed that a contraction-induced increase in tricarboxylic acid cycle intermediates (TCAI) is obligatory for the increase in muscle oxygen uptake at the start of exercise. To test this hypothesis, we measured changes in muscle TCAI during the initial seconds of intense exercise and used...... 25.6+/-4.1 mmol kg(-1) d.w.). Taken together with our previous observation that DCA does not alter muscle oxygen uptake during the initial phase of intense leg kicking exercise (Bangsbo et al. Am J Physiol 282:R273-R280, 2002), the present data suggest that muscle TCAI accumulate during the initial...

  20. Assessment of Muscle Pain Induced by Elbow-Flexor Eccentric Exercise.

    Science.gov (United States)

    Lau, Wing Yin; Blazevich, Anthony J; Newton, Michael J; Wu, Sam Shi Xuan; Nosaka, Kazunori

    2015-11-01

    Delayed-onset muscle soreness (DOMS) is a common muscle pain that many people experience and is often used as a model of acute muscle pain. Researchers have reported the effects of various interventions on DOMS, but different DOMS assessment protocols used in these studies make it difficult to compare the effects. To investigate DOMS characteristics after elbow-flexor eccentric exercise to establish a standardized DOMS assessment protocol. Descriptive laboratory study. Research laboratory. Ten healthy, untrained men (21-39 years). Participants performed 10 sets of 6 maximal isokinetic eccentric contractions of the elbow flexors. Indirect muscle-damage markers were maximal voluntary isometric contraction torque, range of motion, and serum creatine kinase activity. Muscle pain was assessed before exercise, immediately postexercise, and 1 to 5 days postexercise using (1) a visual analog scale (VAS), (2) a category ratio-10 scale (CR-10) when applying static pressure and palpation at different sites (3, 9, and 15 cm above the elbow crease), and (3) pressure-pain thresholds (PPTs) at 50 sites (pain mapping). Maximal voluntary isometric contraction and range of motion decreased and creatine kinase activity increased postexercise, indicating muscle damage. Palpation induced greater pain than static pressure, and longitudinal and transverse palpations induced greater pain than circular palpation (P exercise, but the pain-sensitive regions shifted to the central and distal regions of the biceps brachii at 1 to 3 days postexercise (P eccentric exercise.

  1. The effects of topical Arnica on performance, pain and muscle damage after intense eccentric exercise.

    Science.gov (United States)

    Pumpa, Kate L; Fallon, Kieran E; Bensoussan, Alan; Papalia, Shona

    2014-01-01

    The aim of the study was to determine if topical Arnica is effective in reducing pain, indicators of inflammation and muscle damage, and in turn improve performance in well-trained males experiencing delayed onset muscle soreness (DOMS). Twenty well-trained males matched by maximal oxygen uptake (V̇O2 Max) completed a double-blind, randomised placebo-controlled trial. Topical Arnica was applied to the skin superficial to the quadriceps and gastrocnemius muscles immediately after a downhill running protocol designed to induce DOMS. Topical Arnica was reapplied every 4 waking hours for the duration of the study. Performance measures (peak torque, countermovement and squat jump), pain assessments (visual analogue scale (VAS) and muscle tenderness) and blood analysis (interleukin-1 beta, interleukin-6, tumour necrosis factor-alpha, C-reactive protein, myoglobin and creatine kinase) were assessed at seven time points over five days (pre-, post-, 4, 24, 48, 72 and 96 hours after the downhill run). Participants in the topical Arnica group reported less pain as assessed through muscle tenderness and VAS 72 hours post-exercise. The application of topical Arnica did not affect any performance assessments or markers of muscle damage or inflammation. Topical Arnica used immediately after intense eccentric exercise and for the following 96 hours did not have an effect on performance or blood markers. It did however demonstrate the possibility of providing pain relief three days post-eccentric exercise.

  2. Lipid profiles of adipose and muscle tissues in mouse models of juvenile onset of obesity without high fat diet induction: a Fourier transform infrared (FT-IR) spectroscopic study.

    Science.gov (United States)

    Sen, Ilke; Bozkurt, Ozlem; Aras, Ebru; Heise, Sebastian; Brockmann, Gudrun Anni; Severcan, Feride

    2015-06-01

    The current study aims to determine lipid profiles in terms of the content and structure of skeletal muscle and adipose tissues to better understand the characteristics of juvenile-onset spontaneous obesity without high fat diet induction. For the purposes of this study, muscle (longissimus, quadriceps) and adipose (inguinal, gonadal) tissues of 10-week-old male DBA/2J and Berlin fat mouse inbred (BFMI) lines (BFMI856, BFMI860, BFMI861) fed with a standard breeding diet were used. Biomolecular structure and composition was determined using attenuated total reflection Fourier transform (ATR FT-IR) spectroscopy, and muscle triglyceride content was further quantified using high-performance liquid chromatography (HPLC) coupled with an evaporative light scattering detector (ELSD). The results revealed a loss of unsaturation in BFMI860 and BFMI861 lines in both muscles and inguinal adipose tissue, together with a decrease in the hydrocarbon chain length of lipids, especially in the BFMI860 line in muscles, suggesting an increased lipid peroxidation. There was an increase in saturated lipid and triglyceride content in all tissues of BFMI lines, more profoundly in longissimus muscle, where the increased triglyceride content was quantitatively confirmed by HPLC-ELSD. Moreover, an increase in the metabolic turnover of carbohydrates in muscles of the BFMI860 line was observed. The results demonstrated that subcutaneous (inguinal) fat also displayed considerable obesity-induced alterations. Taken together, the results revealed differences in lipid structure and content of BFMI lines, which may originate from different insulin sensitivity levels of the lines, making them promising animal models for spontaneous obesity. The results will contribute to the understanding of the generation of insulin resistance in obesity without high fat diet induction.

  3. The use of argon beam coagulation in pressure sore reconstruction.

    Science.gov (United States)

    Buck, Donald W; Lewis, Victor L

    2009-12-01

    Pressure sores are a significant source of physical and financial burden for debilitated patients. When conservative measures fail, surgical reconstruction with myocutaneous flaps may be the last hope for cure and/or improved quality of life in these patients. Adequate haemostasis is an integral component of these reconstructive procedures, as bleeding and haematoma formation can lead to increased morbidity. This study was designed to investigate the use of argon beam coagulation in patients undergoing bony debridement and subsequent pressure sore reconstruction with myocutaneous flaps. The clinical records of 34 patients undergoing pressure sore reconstruction with the use of argon beam coagulation from 2004 to 2006 at an academic institution were reviewed and outcomes were assessed. Reconstruction was performed by a single surgeon on 34 patients (31 men, three women; mean age 41+/-15 years), with a total of 41 pressure sores. Thirteen (32.5%) patients had evidence of osteomyelitis preoperatively and five (12.5%) had previous coccygectomies secondary to infection. Twenty-six (65%) of the pressure sores were treated with hamstring V-Y musculocutaneous flaps, 10 (25%) with gluteal flaps, and four (10%) with tensor fascia lata flaps. Overall, suture line dehiscence occurred in six (15%) cases, flap failure and pressure sore recurrence occurred in six (15%) cases, an abscess developed in one (2.5%) case, and a sinus tract with a superficial wound developed in one (2.5%) case. There were no complications related to haemostasis, including excessive bleeding or haematoma formation. Argon beam coagulation is an efficacious tool for achieving adequate haemostasis during pressure sore reconstruction, particularly when significant bony debridement is involved. The use of argon beam coagulation does not result in an increased complication or recurrence rate when compared with conventional electrocautery methods.

  4. Acute effects of blood flow restriction on muscle activity and endurance during fatiguing dynamic knee extensions at low load.

    Science.gov (United States)

    Wernbom, Mathias; Järrebring, Rickard; Andreasson, Mikael A; Augustsson, Jesper

    2009-11-01

    The purpose of this study was to investigate muscle activity and endurance during fatiguing low-intensity dynamic knee extension exercise with and without blood flow restriction. Eleven healthy subjects with strength training experience performed 3 sets of unilateral knee extensions with no relaxation between repetitions to concentric torque failure at 30% of the 1 repetition maximum. One leg was randomized to exercise with cuff occlusion and the other leg to exercise without occlusion. The muscle activity in the quadriceps was recorded with electromyography (EMG). Ratings of perceived exertion (RPE) and acute pain were collected immediately, and delayed onset muscle soreness (DOMS) was rated before and at 24, 48, and 72 hours after exercise. The results demonstrated high EMG levels in both experimental conditions, but there were no significant differences regarding maximal muscle activity, except for a higher EMG in the eccentric phase in set 3 for the nonoccluded condition (p = 0.005). Significantly more repetitions were performed with the nonoccluded leg in every set (p knee extension decreases the endurance but does not increase the maximum muscle activity compared with training without restriction when both regimes are performed to failure. The high levels of muscle activity suggest that performing low-load dynamic knee extensions in a no-relaxation manner may be a useful method in knee rehabilitation settings when large forces are contraindicated. However, similarly to fatiguing blood flow restricted exercise, this method is associated with ischemic muscle pain, and thus its applications may be limited to highly motivated individuals.

  5. Modified lumbar artery perforator flaps for gluteal pressure sore reconstruction.

    Science.gov (United States)

    Yoon, Chi Sun; Yim, Ji Hong; Kim, Min Ho; Ha, Won; Kim, Kyu Nam

    2016-03-21

    Gluteal perforator flaps (GPFs) are the most useful for gluteal region pressure sore reconstruction. However, application is difficult if the surrounding area has scar tissue from previous operations or trauma, especially with recurrent sores. We describe the use of modified lumbar artery perforator flaps when GPFs cannot be used. Between May 2009 and April 2014, 51 patients underwent gluteal pressure sore reconstructions with gluteal (n = 39) or modified lumbar artery (n = 12) perforator flaps. Patients in the modified lumbar artery perforator group had scar tissue from trauma or previous surgery. In this retrospective review, we analyzed patient age and sex, defect size and location, operative time, follow-up duration, immediate postoperative issues, flap necrosis, dehiscence, re-operation, donor-site morbidity and recurrence. Complications and clinical outcomes were compared between groups. We found no significant differences in patient demographics, surgical complications or clinical outcomes. There were eight cases of temporary congestion (20.51%) and four of partial flap necrosis (10.25%) in the gluteal perforator group. In the modified lumbar artery perforator group, there were three cases of temporary congestion (25%) and one of partial flap necrosis (8.33%). No pressure sores recurred during follow-up in either group. GPFs are the gold standards for gluteal pressure sores, but modified lumbar artery perforator flaps are relatively easy and useful when GPFs cannot be used due to scar tissue. © 2016 Royal Australasian College of Surgeons.

  6. Nursing aspects of pressure sore prevention and therapy.

    Science.gov (United States)

    Culley, F

    Pressure sores remain a significant problem in hospitals and domestic settings, affecting people of all ages, social class and race. Associated complications may be life threatening, e.g. sepsis and osteomyelitis. Other less dangerous, but nevertheless compromising outcomes such as pain, discomfort and low self-esteem and body image can cause personal suffering, and may add extra demand for limited resources. The exact state of pressure sore occurrence remains difficult to determine, particularly in the community. Recent trends in pressure area management present a multidisciplinary approach, eroding traditional perceptions of pressure sores as a solely nursing problem. Written from nursing perspective, this article summarizes principles of good practice relating to pressure sore prevention and therapy, emphasizing the importance of documenting observed events, rather than assumptions or opinions, and the need for healthcare professionals to approach problems and needs from a collaborative stance. Pressure sore risk assessment and classification are discussed, and an overview of nutrition, moving a handling, selecting support surfaces, principles of wound management, and skin care are considered.

  7. Effects of Massage on Muscular Strength and Proprioception After Exercise-Induced Muscle Damage.

    Science.gov (United States)

    Shin, Mal-Soon; Sung, Yun-Hee

    2015-08-01

    Exercise-induced muscle damage (EIMD), which is commonly associated with eccentric exercise, unaccustomed exercise, and resistance training, may lead to delayed onset muscle soreness, swelling, decreased muscle strength, and range of motion. Many researchers have evaluated various interventions to treat the signs and symptoms of EIMD. However, the effects of massage after EIMD are unclear. Here, we investigated the effect of massage on muscle strength and proprioception after EIMD. All subjects randomly were divided into an EIMD-treated control group (n = 10) and a massage-treated after EIMD experimental group (n = 11). Exercise-induced muscle damage was induced by repeated exercise. Massage treatment was provided by physiotherapist for 15 minutes. It consists of light stroking, milking, friction, and skin rolling. Lactate was evaluated by Lactate Pro analyzer in pre- and postexercise. Surface electromyography (muscle activity) and sonography (muscle thickness) were used to confirm the muscular characteristics. Proprioception was investigated by dual inclinometer. As a result, massage treatment on the gastrocnemius after EIMD increased activation of the medial gastrocnemius during contraction (p ≤ 0.05). In the lateral and medial gastrocnemius, the θs, which is the angle between muscle fibers and superficial aponeurosis, showed a significant change (p ≤ 0.05). However, there are no differences in the θd, which is the angle between muscle fibers and deep aponeurosis. We also found that proprioceptive acuity in the ankle joint was significantly greater in the massage-treated experimental group compared with that in the control group (p ≤ 0.05). These findings suggest that massage of the gastrocnemius after EIMD can improve muscle strength and proprioception by influencing the superficial layer of the gastrocnemius.

  8. Acute sore throat | EU Clinical Trials Register [EU Clinical Trials Register

    Lifescience Database Archive (English)

    Full Text Available Trial E.1 Medical condition or disease under investigation E.1.1Medical condition(s) being investigated Acute... sore throat E.1.1.1Medical condition in easily understood language Acute sore

  9. Magnesium and Ketamine Gargle and Postoperative Sore Throat.

    Science.gov (United States)

    Teymourian, Houman; Mohajerani, Seyed Amir; Farahbod, Alireza

    2015-06-01

    Postoperative sore throat is one of the most common complications after endotracheal intubation. Both Ketamine and magnesium can block N-methyl-D-aspartic acid (NMDA) receptors and provide central and local analgesia. To compare the effect of magnesium sulfate and ketamine gargle on the incidence and severity of postoperative sore throat. A total of 100 patients candidate for emergency acute appendicitis surgery were enrolled in the study. Patients in ketamine group received ketamine gargle (0.5 mg/kg) and magnesium group received magnesium sulfate gargle (20 mg/kg up to 30 mL dextrose water 20%) 15 minutes before the operation. Patient complaint of postoperative sore throat, and its severity measured by visual analogue scale (VAS) were recorded at baseline in recovery room, and then 2, 4, and 24 hours after operation. There were no significant differences between age, sex, and body mass index (BMI) between two groups of patients. Hemodynamics of patients, including blood pressure, respiratory rate, oxygen saturation %, and conscious state were not significantly different (P > 0.05). Number of patients with sore throat were significantly lower in magnesium group compared to ketamine group at 2 (P = 0.032), 4 (P = 0.02), and 24 hours (P = 0.01) after the operation. Sore throat pain score (VAS) was significantly lower in magnesium group compared to ketamine group at 2 (P = 0.019), 4 (P = 0.028), and 24 hours (P = 0.014) after the operation. Magnesium at low dose decreases sore throat and pain severity more effectively compared to ketamine gargle.

  10. Beds, mattresses and cushions for pressure sore prevention and treatment.

    Science.gov (United States)

    Cullum, N; Deeks, J; Sheldon, T A; Song, F; Fletcher, A W

    2000-01-01

    To assess the effectiveness of pressure relieving beds, mattresses and cushions (support surfaces) in the prevention and treatment of pressure sores. Searches of 19 databases, hand searching of journals, conference proceedings, and bibliographies. Randomised controlled trials evaluating support surfaces for the prevention or treatment of pressure sores. There was no restriction on articles based on language or publication status. Data extraction and assessment of study quality was undertaken by two reviewers independently. Trials with similar patients, comparisons, and outcomes were pooled. Where pooling was inappropriate, trials are discussed in a narrative review. 29 RCTs of support surfaces for pressure sore prevention were identified. Some high specification foam mattresses were more effective than 'standard' hospital foam mattresses in moderate-high risk patients. Pressure relieving mattresses in the operating theatre reduced the incidence of pressure sores post-operatively. The relative merits of alternating and constant low pressure, and of the different alternating pressure devices are unclear. Seat cushions and simple, constant low-pressure devices have not been adequately evaluated. Limited evidence suggests that low air loss beds reduce the incidence of pressure sores in intensive care. 6 RCTs of support surfaces for pressure sore treatment were identified. There is good evidence that air-fluidised and low air loss beds improve healing rates. Seat cushions have not been adequately evaluated. 2 RCTs evaluated surfaces for both prevention and treatment in the same trial. PREVENTION - There is good evidence of the effectiveness of high specification foam over standard hospital foam, and pressure relief in the operating theatre. Treatment - There is good evidence of the effectiveness of air-fluidised and low air loss devices as treatments. Overall, however, it is impossible to determine the most effective surface for either prevention or treatment.

  11. Comparison of outcomes of pressure sore reconstructions among perforator flaps, perforator-based rotation fasciocutaneous flaps, and musculocutaneous flaps.

    Science.gov (United States)

    Kuo, Pao-Jen; Chew, Khong-Yik; Kuo, Yur-Ren; Lin, Pao-Yuan

    2014-10-01

    Pressure sore reconstruction remains a significant challenge for plastic surgeons due to its high postoperative complication and recurrence rates. Free-style perforator flap, fasciocutaeous flap, and musculocutaneous flap are the most common options in pressure sore reconstructions. Our study compared the postoperative complications among these three flaps at Kaohsiung Chang Gung Memorial Hospital. From 2003 to 2012, 99 patients (54 men and 45 women) with grade III or IV pressure sores received regional flap reconstruction, consisting of three cohorts: group A, 35 free-style perforator-based flaps; group B, 37 gluteal rotation fasciocutaneous flaps; and group C, 27 musculocutaneous or muscle combined with fasciocutaneous flap. Wound complications such as wound infection, dehiscence, seroma formation of the donor site, partial or complete flap loss, and recurrence were reviewed. The mean follow-up period for group A was 24.2 months, 20.8 months in group B, and 19.0 months for group C. The overall complication rate was 22.9%, 32.4%, and 22.2% in groups A, B, and C, respectively. The flap necrosis rate was 11.4%, 13.5%, and 0% in groups A, B, and C, respectively. There was no statistical significance regarding complication rate and flap necrosis rate among different groups. In our study, the differences of complication rates and flap necrosis rate between these groups were not statistically significant. Further investigations should be conducted. © 2014 Wiley Periodicals, Inc.

  12. [Clinical typing and surgical principle of pressure sore].

    Science.gov (United States)

    Liu, Yi; Zhang, Xusheng; Zhang, Cheng

    2007-09-01

    To investigate the clinical typing and their relevant surgical treatment principle and method of pressure sore. From January 1983 to April 2006, 122 patients with 179 pressure sores were treated. There were 93 males and 29 females, aging 15-68 years. The pressure sores were located at sacrococcygeus (54 lesions), petrochanteric region (37 lesions), ischial tuberosity (30 lesions), heel (17 lesions), olecranon (15 lesions), scapula (9 lesions), lateral malleolar (7 lesions), caput fibulace (4 lesions), pretibial (3 lesions), and lumbar region (3 lesims) respectivly. The disease course was from 2 months to 11 years. The areas of pressure sores were from 1.5 cm x 1.0 cm to 20.0 cm x 18.0 cm. According to the wound characteristics, the pressure sores were divided into three types: sinus type (12/179), ulcer type (74/179) and mixed type (93/179). Aimed at different types of pressure sore, skin grafting, skin flap and myocutaneous flap were employed to repair wound. The areas of flaps were from 5.0 cm x 3.5 cm to 26.0 cm x 14.5 cm. The areas of skin grafting were from 7 cm x 5 cm to 23 cm x 12 cm. All wounds of sinus type healed by first intention except one; and all flaps survived. All wounds of uler type healed by first intention; and the flaps survived completely except two which had a partial necrosis. All flaps which harvested to repair 93 pressure sores of mixed type were survived. But one or two sinus occurred in 8 cases. Two healed by operation, and the others healed by dressing exchange. The wounds healed by first intention. The donor sites healed by first intention. The routine follow-up in 73 patients after 6 months showed that the recurrence appeared in 4 mixed type. The recurrence rate was 5.5% and the other patients had good outcome. Clinical typing of pressure sore is helpful to select the suitable operation method and improve the rate of success.

  13. Type of Ground Surface during Plyometric Training Affects the Severity of Exercise-Induced Muscle Damage

    Directory of Open Access Journals (Sweden)

    Hamid Arazi

    2016-03-01

    Full Text Available The purpose of this study was to compare the changes in the symptoms of exercise-induced muscle damage from a bout of plyometric exercise (PE; 10 × 10 vertical jumps performed in aquatic, sand and firm conditions. Twenty-four healthy college-aged men were randomly assigned to one of three groups: Aquatic (AG, n = 8, Sand (SG, n = 8 and Firm (FG, n = 8. The AG performed PE in an aquatic setting with a depth of ~130 cm. The SG performed PE on a dry sand surface at a depth of 20 cm, and the FG performed PE on a 10-cm-thick wooden surface. Plasma creatine kinase (CK activity, delayed onset muscle soreness (DOMS, knee range of motion (KROM, maximal isometric voluntary contraction (MIVC of the knee extensors, vertical jump (VJ and 10-m sprint were measured before and 24, 48 and 72 h after the PE. Compared to baseline values, FG showed significantly (p < 0.05 greater changes in CK, DOMS, and VJ at 24 until 48 h. The MIVC decreased significantly for the SG and FG at 24 until 48 h post-exercise in comparison to the pre-exercise values. There were no significant (p > 0.05 time or group by time interactions in KROM. In the 10-m sprint, all the treatment groups showed significant (p < 0.05 changes compared to pre-exercise values at 24 h, and there were no significant (p > 0.05 differences between groups. The results indicate that PE in an aquatic setting and on a sand surface induces less muscle damage than on a firm surface. Therefore, training in aquatic conditions and on sand may be beneficial for the improvement of performance, with a concurrently lower risk of muscle damage and soreness.

  14. The effects of muscle damage following eccentric exercise on gait biomechanics.

    Science.gov (United States)

    Paschalis, Vassilis; Giakas, Giannis; Baltzopoulos, Vassilios; Jamurtas, Athanasios Z; Theoharis, Vassilios; Kotzamanidis, Christos; Koutedakis, Yiannis

    2007-02-01

    To examine the effects of knee extensors muscle damage on walking and running biomechanics in healthy males. Muscle damage was caused by 60 (6x10) maximal eccentric knee flexions of both legs, selected in a random order, at an angular velocity of 1.05rad/s in 10 volunteers (mean age 20+/-1.0 years). Muscle damage indicators (creatine kinase (CK), lactate dehydrogenase (LDH), delayed onset muscle soreness (DOMS), eccentric and isometric (110 degrees knee flexion) peak torque), pelvic three dimensional (3D) orientation, as well as hip, knee and ankle-joint flexion/extension angles during gait (walking at 1.2m/s and running at 2.8m/s) were assessed pre- and 48h post-eccentric exercise. All muscle damage indicators revealed significant changes post- compared to pre-exercise data (Pknee-joint angle range of movement at the stance and swing phases during walking (Pknee extensors result in changes of treadmill walking and running kinematics at both knee joint and pelvis. The fact that these alterations occur at different gait phases could be attributed to the speed of movement and to a self-protection mechanism to prevent further damage.

  15. Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes.

    Science.gov (United States)

    Nieman, David C; Gillitt, Nicholas D; Shanely, R Andrew; Dew, Dustin; Meaney, Mary Pat; Luo, Beibei

    2013-12-20

    This study determined if 6-weeks vitamin D2 supplementation (vitD2, 3800 IU/day) had an influence on muscle function, eccentric exercise-induced muscle damage (EIMD), and delayed onset of muscle soreness (DOMS) in National Association for Stock Car Auto Racing (NASCAR) NASCAR pit crew athletes. Subjects were randomized to vitD2 (n=13) and placebo (n=15), and ingested supplements (double-blind) for six weeks. Blood samples were collected and muscle function tests conducted pre- and post-study (leg-back and hand grip dynamometer strength tests, body weight bench press to exhaustion, vertical jump, 30-s Wingate test). Post-study, subjects engaged in 90 min eccentric-based exercise, with blood samples and DOMS ratings obtained immediately after and 1- and 2-days post-exercise. Six weeks vitD2 increased serum 25(OH)D2 456% and decreased 25(OH)D3 21% versus placebo (peccentric exercise bout induced EIMD and DOMS, with higher muscle damage biomarkers measured in vitD2 compared to placebo (myoglobin 252%, 122% increase, respectively, p=0.001; creatine phosphokinase 24 h post-exercise, 169%, 32%, peccentric exercise.

  16. [An assessment scale for the prevention of pressure sores in children].

    Science.gov (United States)

    Chauvet, Corinne; Poirier, Marie-Renée; Sourisseau, Petronela Rachieru; Béduneau, Denis; Soulard, Anthony; Delacroix, Delphine

    2015-04-01

    Pressure sores in children are rare. However, when they do occur they can have significant consequences. Professionals in paediatric units realised the importance of assessing the risk of pressure sores and developed a pressure sore assessment scale specific to children. This project, carried out through a hospital-training school partnership, emphasises the importance of clinical reasoning in nursing practices.

  17. Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

    Science.gov (United States)

    Borghi, Sergio M.; Pinho-Ribeiro, Felipe A.; Fattori, Victor; Bussmann, Allan J. C.; Vignoli, Josiane A.; Camilios-Neto, Doumit; Casagrande, Rubia; Verri, Waldiceu A.

    2016-01-01

    The present study aimed to evaluate the effects of the flavonoid quercetin (3,3´,4´,5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-β-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFκB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise. PMID:27583449

  18. An Algorithm for Detecting the Onset of Muscle Contraction Based on Generalized Likelihood Ratio Test%采用广义似然比检测的肌肉收缩起始时刻判断算法

    Institute of Scientific and Technical Information of China (English)

    徐琦; 程俊银; 周慧; 杨磊

    2012-01-01

    The surface electromyography (sEMG) of stump in the amputee is often applied to control the action of myoelectric prosthesis. According to the sEMG signals with low Signal to Noise Ratio (SNR) recorded from the stump muscle,a generalized likelihood ratio (GLR) method was proposed to detect the onset of muscle contraction,where a decision threshold was related with the SNR of sEMG signals,an off-line simulation method was used to determine the relationship between them. For the simulated sEMG signals with a given SNR,the different thresholds were tested,the optimal threshold could be obtained when the detection accuracy was optimized. As a result,the fitted curve was achieved to describe the relationship of the SNR and the decision threshold. Then,the sEMG signals are analyzed on-line by the GLR test for the onset detection of muscle contractions,while the decision threshold corresponding with the SNR was chosen based on the fitted curve. Compared with the classical algorithms,with the simulated sEMG traces,the error mean and standard deviation for estimating the muscle contraction onset were reduced at least 35% and 43% respectively; based on the real EMG signals,the error mean and standard deviation of the onset estimate were separately not less than 29% and 23%. Therefore,the proposed algorithm based on GLR test for the onset detection of muscle contraction was more accurate than other methods,while the SNR of sEMG signals was low.%肌电假肢利用残肢残存肌肉的肌电信号实行对假肢的控制.对于低信噪比的残肢表面肌电,本研究采用广义似然比检测方法判断肌肉收缩起始时刻,其中判别阈值与肌电信号信噪比有关.针对不同信噪比的模拟肌电信号,采用离线仿真方法得到肌肉收缩起始时刻检测误差最小的判别阈值,得到信噪比-经验阈值拟合曲线,确定信噪比与阈值的对应关系;根据肌电信噪比由阈值拟合曲线得到判别阈值,采用似然比检测算法

  19. Effects of Electrical Stimulation of Different Frequencies on Delayed Onset of Muscle Soreness and Muscle Strength%不同频率电刺激对运动延迟性肌肉酸痛和肌肉收缩力量的影响

    Institute of Scientific and Technical Information of China (English)

    田野; 戴维; 聂金雷

    2003-01-01

    目的:观察经皮电刺激对离心运动后延迟性肌肉酸痛、主观体力感觉及肌肉力量恢复的影响.方法:24名男性大学生分别完成10组负荷,每组负荷由15个蛙跳(最大用力)和30个负重跳(10kg)组成.运动后受试者随机分为实验组与对照组.实验组接受电刺激治疗.运动前及运动后分别测定肌肉酸痛程度、主观体力感觉及肌肉等动力量.结果:与对照组相比,实验组在运动后24 h、48 h及72 h肌肉酸痛程度明显降低.但各组间肌肉力量及主观体力感觉无显著差异.结论:经皮电刺激对肌肉酸痛的消除有积极作用,而对肌肉功能及主观体力感觉的恢复无明显影响.

  20. When a Sore Throat Is a More Serious Infection

    Science.gov (United States)

    ... or bloody nasal discharge with a fever. Such children are usually quite cranky, have no appetite, and often have swollen glands in the neck. Sometimes toddlers will complain of tummy pain instead of a sore throat. Children over three years of age with strep are ...

  1. Antibiotic prescribing in patients with self-reported sore throat

    NARCIS (Netherlands)

    Mehta, Nishchay; Schilder, Anne; Fragaszy, Ellen; E R Evans, Hannah; Dukes, Oliver; Manikam, Logan; Little, Paul; Smith, Sarah C; Hayward, Andrew

    2017-01-01

    OBJECTIVES: To investigate the predictors of general practitioner (GP) consultation and antibiotic use in those developing sore throat. METHODS: We conducted a prospective population-based cohort study on 4461 participants in two rounds (2010-11) from 1897 households. RESULTS: Participants reported

  2. Characteristics of children consulting for cough, sore throat, or earache

    NARCIS (Netherlands)

    J.H.J.M. Uijen (Hans); H.J. van Duijn (Huug); M.M. Kuyvenhoven (Marijke); F.G. Schellevis (François); J.C. van der Wouden (Hans)

    2008-01-01

    textabstractAbstract BACKGROUND: GPs are often consulted for respiratory tract symptoms in children. AIM: To explore characteristics of children, their parents, and their GPs that are correlated with consulting a GP for cough, sore throat, or earache. DESIGN OF STUDY: Second Dutch National Survey o

  3. Characteristics of children consulting for cough, sore throat, or earache.

    NARCIS (Netherlands)

    Uijen, H.J.M.; Duijn, H.J. van; Kuyvenhoven, M.M.; Schellevis, F.G.; Wouden, J.C. van der

    2008-01-01

    BACKGROUND: GPs are often consulted for respiratory tract symptoms in children. AIM: To explore characteristics of children, their parents, and their GPs that are correlated with consulting a GP for cough, sore throat, or earache. DESIGN OF STUDY: Second Dutch National Survey of General Practice (DN

  4. Characteristics of children consulting for cough, sore throat, or earache

    NARCIS (Netherlands)

    Uijen, Johannes H. J. M.; van Duijn, Huug J.; Kuyvenhoven, Marijke M.; Schellevis, Francois G.; van der Wouden, Johannes C.

    2008-01-01

    Background GPs are often consulted for respiratory tract symptoms in children. Aim To explore characteristics of children, their parents, and their GPs that are correlated with consulting a GP for cough, sore throat, or earache. Design of study Second Dutch National Survey of General Practice (DNSGP

  5. Pedicled fillet of leg flap for extensive pressure sore coverage.

    Science.gov (United States)

    Jandali, Shareef; Low, David W

    2009-10-27

    Multiple large decubitus ulcers present a reconstructive challenge to the plastic surgeon. When stage IV pressure sores become recurrent or extensive, traditional flaps either have already been exhausted or would not be sufficient to cover the defect. A retrospective review was performed on all paraplegic patients who had chronic, extensive, and stage IV decubitus ulcers, and underwent reconstruction using a pedicled continuous musculocutaneous flap of the entire leg between 1998 and 2007. The extent and size of the debrided pressure sores, number of previous flap reconstructions, intraoperative blood loss, postoperative complications, and years of follow-up were all recorded. A description of the operative technique is also given. Four patients underwent a total leg fillet flap in the study period, with follow-up ranging from 2 to 7 years. Indications included extensive and bilateral trochanteric, sacral, and ischial pressure sores. Complications included intraoperative blood loss and postoperative heterotopic calcification. The total leg fillet flap is a very large and robust flap that offers paraplegic patients coverage of extensive stage IV pressure sores of the trochanteric, sacral, and ischial areas.

  6. Bed surfaces and pressure sore prevention: an abridged report.

    Science.gov (United States)

    Brown, S J

    2001-01-01

    This article summarizes the results of a systematic review of randomized controlled trials testing the effectiveness of special beds, mattresses, and cushions in preventing and treating pressure sores. The review's citation is Cullum, N., Deeks, J., Sheldon, T.A., Song, F., & Fletcher, A.W. (2000). Beds, mattresses and cushions for pressure sore prevention and treatment (Cochrane Review). The Cochrane Library, 4. An integrative research review. 37 studies were included in the analysis. A broad search of databases and unpublished studies was conducted. Data were extracted from those that met the inclusion criteria. Studies were grouped in various ways but mainly by type of product evaluated. Many special products designed to prevent or treat pressure sores are more effective than standard hospital foam mattresses in preventing and treating pressure sores. Special pressure-relieving surfaces should be used for patients at risk for skin breakdown. Individual practitioners and agencies should have a systematic protocol for assessing patients' risk of skin breakdown and for taking action when patients are determined to be at risk. The findings of this review provide some guidance for choosing particular products, albeit not definitive evidence for matching risk levels to products.

  7. Metabolic demand and muscle damage induced by eccentric cycling of knee extensor and flexor muscles.

    Science.gov (United States)

    Peñailillo, Luis; Guzmán, Nicolás; Cangas, José; Reyes, Alvaro; Zbinden-Foncea, Hermann

    2017-03-01

    The aim of this study was to examine the metabolic demand and extent of muscle damage of eccentric cycling targeting knee flexor (FLEX) and knee extensor (EXT) muscles. Eight sedentary men (23.3 ± 0.7 y) underwent two eccentric cycling sessions (EXT and FLEX) of 30 min each, at 60% of the maximum power output. Oxygen consumption (VO2), heart rate (HR) and rated perceived exertion (RPE) were measured during cycling. Countermovement and squat jumps (CMJ and SJ), muscle flexibility, muscle soreness and pain pressure threshold (PPT) of knee extensor and flexor muscles were measured before, immediately after and 1-4 days after cycling. FLEX showed greater VO2 (+23%), HR (+14%) and RPE (+18%) than EXT. CMJ and SJ performance decreased similarly after cycling. Muscle soreness increased more after EXT than FLEX and PPT decreased in knee extensor muscles after EXT and decreased in knee flexor muscles after FLEX. Greater loss of muscle flexibility in knee flexor muscles after FLEX was observed. Eccentric cycling of knee flexor muscles is metabolically more demanding than that of knee extensors, however muscle damage induced is similar. Knee flexors experienced greater loss of muscle flexibility possibly due to increased muscle stiffness following eccentric contractions.

  8. Predictors of postoperative sore throat in intubated children.

    Science.gov (United States)

    Calder, Alyson; Hegarty, Mary; Erb, Thomas O; von Ungern-Sternberg, Britta S

    2012-03-01

    The incidence of postoperative sore throat (POST) following intubation is not well defined in the pediatric population. The etiology is multifactorial and includes impairment of subglottic mucosal perfusion and edema as a result of the pressures exerted by cuffed or uncuffed tubes. To determine the incidence of, and risk factors for, POST in intubated children undergoing elective day-case surgery. Five hundred patients aged 3-16 years were studied prospectively. Endotracheal tube (ETT) choice (cuffed or uncuffed) was left to the anesthetist. The cuff was inflated either until loss of audible leak or to a determined pressure using a cuff manometer. The research team then measured the cuff pressure (CP). POST incidence and intensity was determined by interviewing patients prior to discharge from the same day procedure unit. Chi-square testing and stepwise logistic regression were used to determine the predictors of POST. Of the 111 (22%) children developed a sore throat, 19 (3.8%) a sore neck, and 5 (1%) a sore jaw. 19% of patients with cuffed ETTs complained of sore throat compared with 37% of those intubated with an uncuffed ETT. The incidence of POST increased with CP; 0-10% at 0 cmH(2)O, 4% at 11-20 cmH(2)O, 20% at 21-30 cmH(2)O, 68% at CP 31-40 cmH(2)O, and 96% at CP >40 cmH(2)O. The ETT CP and use of uncuffed ETTs were univariate predictors of POST. Children intubated with uncuffed ETTs are more likely to have POST. ETT CP is positively correlated with the incidence of POST. When using cuffed ETTs, CP should be routinely measured intraoperatively. © 2011 Blackwell Publishing Ltd.

  9. Ibuprofen ingestion does not affect markers of post-exercise muscle inflammation.

    Directory of Open Access Journals (Sweden)

    Luke eVella

    2016-03-01

    Full Text Available Purpose: We investigated if oral ingestion of ibuprofen influenced leucocyte recruitment and infiltration following an acute bout of traditional resistance exercise. Methods: Sixteen male subjects were divided into two groups that received the maximum over-the-counter dose of ibuprofen (1200 mg d-1 or a similarly administered placebo following lower body resistance exercise. Muscle biopsies were taken from m.vastus lateralis and blood serum samples were obtained before and immediately after exercise, and at 3 h and 24 h after exercise. Muscle cross-sections were stained with antibodies against neutrophils (CD66b and MPO and macrophages (CD68. Muscle damage was assessed via creatine kinase and myoglobin in blood serum samples, and muscle soreness was rated on a ten-point pain scale. Results: The resistance exercise protocol stimulated a significant increase in the number of CD66b+ and MPO+ cells when measured 3 h post exercise. Serum creatine kinase, myoglobin and subjective muscle soreness all increased post-exercise. Muscle leucocyte infiltration, creatine kinase, myoglobin and subjective muscle soreness were unaffected by ibuprofen treatment when compared to placebo. There was also no association between increases in inflammatory leucocytes and any other marker of cellular muscle damage. Conclusion: Ibuprofen administration had no effect on the accumulation of neutrophils, markers of muscle damage or muscle soreness during the first 24 h of post-exercise muscle recovery.

  10. Vitamin D2 Supplementation Amplifies Eccentric Exercise-Induced Muscle Damage in NASCAR Pit Crew Athletes

    Directory of Open Access Journals (Sweden)

    David C. Nieman

    2013-12-01

    Full Text Available This study determined if 6-weeks vitamin D2 supplementation (vitD2, 3800 IU/day had an influence on muscle function, eccentric exercise-induced muscle damage (EIMD, and delayed onset of muscle soreness (DOMS in National Association for Stock Car Auto Racing (NASCAR NASCAR pit crew athletes. Subjects were randomized to vitD2 (n = 13 and placebo (n = 15, and ingested supplements (double-blind for six weeks. Blood samples were collected and muscle function tests conducted pre- and post-study (leg-back and hand grip dynamometer strength tests, body weight bench press to exhaustion, vertical jump, 30-s Wingate test. Post-study, subjects engaged in 90 min eccentric-based exercise, with blood samples and DOMS ratings obtained immediately after and 1- and 2-days post-exercise. Six weeks vitD2 increased serum 25(OHD2 456% and decreased 25(OHD3 21% versus placebo (p < 0.001, p = 0.036, respectively, with no influence on muscle function test scores. The post-study eccentric exercise bout induced EIMD and DOMS, with higher muscle damage biomarkers measured in vitD2 compared to placebo (myoglobin 252%, 122% increase, respectively, p = 0.001; creatine phosphokinase 24 h post-exercise, 169%, 32%, p < 0.001, with no differences for DOMS. In summary, 6-weeks vitD2 (3800 IU/day significantly increased 25(OHD2 and decreased 25(OHD3, had no effect on muscle function tests, and amplified muscle damage markers in NASCAR pit crew athletes following eccentric exercise.

  11. DIFFERENCE IN THE MAGNITUDE OF MUSCLE DAMAGE BETWEEN ELBOW FLEXORS AND KNEE EXTENSORS ECCENTRIC EXERCISES

    Directory of Open Access Journals (Sweden)

    Tolga Saka

    2009-03-01

    Full Text Available The aim of this study was to investigate the difference in the magnitude of muscle damage between maximal eccentric exercises of the elbow flexors (EF and knee extensors (KE. Twelve sedentary male volunteers participated in the study. Range of motion (ROM, isometric peak torque (IPT, delayed onset of muscle soreness (DOMS, creatine kinase activity (CK, and myoglobin concentration (Mb were evaluated before, immediately after, and on the 1st , 2nd, 3rd , and 7th days following exercise. Total work (TW during exercises was recorded and corrected by muscle volume (TWc. TWc was greater (p < 0.01 for EF [24 (2 joule·cm-3] than for KE [7 (0.4 joule·cm-3]. Increases in CK on the 2nd , 3rd , and 7th days (p < 0.01 and increases in Mb on the 1st , 2nd , 3rd , and 7th days were significantly (p<0.01 larger for EF than for KE. The decline in IPT was greater (p < 0.05- 0.01 for EF at all test occasions compared with KE. The results of this study demonstrate that the magnitude of muscle damage is greater and the recovery is slower following maximal eccentric exercise of the EF than of the KE for sedentary males

  12. Eccentric resistance training intensity may affect the severity of exercise induced muscle damage.

    Science.gov (United States)

    Hasenoehrl, Timothy; Wessner, Barbara; Tschan, Harald; Vidotto, Claudia; Crevenna, Richard; Csapo, Robert

    2017-09-01

    The aim of the present study was to assess the role of eccentric exercise intensity in the development of and recovery from delayed onset muscle soreness (DOMS). Using a cross-over study design, 15 healthy, male college students were tested on two occasions. The training stimulus consisted of an exhaustive series of eccentric muscle contractions of the elbow flexors at either 100% (high intensity) or 50% (low intensity) of the individual concentric one-repetition maximum. Blood samples were taken at baseline as well as 24, 48, 72 and 96 hours postexercise, and analyzed for creatine kinase, myoglobin, interleukin-6 and prostaglandin-2. Additionally, upper arm circumference (CIRC) and DOMS-related sensation of pain (PAIN) were measured. Following high intensity training, CIRC was significantly greater (P=0.007). Further, creatine kinase, myoglobin and interleukin-6 tended to be higher, although the main effect of the factor "intensity" just failed to reach significance (creatine kinase: P=0.056, myoglobin: P=0.064, interleukin-6: P=0.091). No differences were found for prostaglandin-2 (P=0.783) and PAIN (P=0.147). When performed at greater intensity, fatiguing eccentric resistance exercise of the elbow flexors leads to greater muscle swelling and, potentially, increases in serum markers reflecting lesions in the muscle's cellular membrane.

  13. 加快非去极化肌松药起效的研究进展%Progress on Methods of Shortening the Onset of Oon-depolarizing Muscle Relaxants

    Institute of Scientific and Technical Information of China (English)

    韩传钢

    2011-01-01

    Non-depolarizing muscle relaxants ( NMR ) are given as part of rapid sequence induction. It is very susceptible to hypoxia and aspiration, as the airway protective reflex is decreased during the induction of anesthesia. In order to prevent aspiration, the time interval between the induction of anesthesia and the tracheal intubation should be kept as short as possible. The methods,including administration of large doses, priming principle, timing principle, combination of drugs, and development of a new NMR,are applied to decrease the onset time of NMR. Each method has its advantages and disadvantages. This review summarizes these methods that shorten the onset of non-depolarizing muscle relaxants.%非去极化肌松药是快速序贯诱导复合用药一个重要组成部分.全麻诱导期间呼吸道保护性反射减弱,极容易发生缺氧、反流误吸等并发症,应尽快行气管插管控制呼吸道,因此,肌松药起效的快慢对麻醉诱导期的安全至关重要.临床上缩短非去极化肌松药起效时间常用的方法包括:增大剂量、预注法、分次注射法和限时法等,每种方法各有优缺点,在此将对这些加速非去极化肌松药起效方法的相关研究进行综述.

  14. Gargling with Ketamine Attenuates the Postoperative Sore Throat

    OpenAIRE

    Rudra, A.; Suchanda Ray; Chatterjee, S.; Ahmed, A; Ghosh, S

    2009-01-01

    Summary Postoperative sore throat (POST) is a common complication of anaesthesia with endotracheal tube that affects patient satisfaction after surgery. Therefore, this complication remains to be resolved in patients undergoing endotracheal intubation. The aim of the study was to compare the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Forty patients scheduled for elective surgery under general anaesthesia were randomized into: Group C, wate...

  15. GARGLING WITH KETAMINE ATTENUATES POST-OPERATIVE SORE THROAT

    OpenAIRE

    Tejashwini; Jagadish

    2014-01-01

    : INTRODUCTION: Postoperative Sore Throat (POST) is a common complication that is unresolved in patients undergoing endotracheal intubation, which is the foremost cause of trauma to the air way mucosa. The reported incident of POST varies from 21% to 65%. We compared the effectiveness of ketamine gargle with placebo in preventing POST after endotracheal intubation. METHODS: A prospective randomized controlled single blind study was conducted involving 60 patients of ASA gr...

  16. Ear Acupuncture for Acute Sore Throat: A Randomized Controlled Trial

    Science.gov (United States)

    2014-09-26

    SEP 2014 2. REPORT TYPE Final 3. DATES COVERED 4. TITLE AND SUBTITLE Ear acupuncture for acute sore throat. A randomized controlled trial...Auncular Acupuncture is a low risk option for acute pain control •Battlefield acupuncture (BFA) IS a specific auncular acupuncture technique •BFA IS...Strengths: Prospect1ve RCT •Weaknesses Small sample stze. no sham acupuncture performed, patients not blinded to treatment •Th1s study represents an

  17. Effects of priming exercise on the speed of adjustment of muscle oxidative metabolism at the onset of moderate-intensity step transitions in older adults.

    Science.gov (United States)

    De Roia, Gabriela; Pogliaghi, Silvia; Adami, Alessandra; Papadopoulou, Christina; Capelli, Carlo

    2012-05-15

    Aging is associated with a functional decline of the oxidative metabolism due to progressive limitations of both O(2) delivery and utilization. Priming exercise (PE) increases the speed of adjustment of oxidative metabolism during successive moderate-intensity transitions. We tested the hypothesis that such improvement is due to a better matching of O(2) delivery to utilization within the working muscles. In 21 healthy older adults (65.7 ± 5 yr), we measured contemporaneously noninvasive indexes of the overall speed of adjustment of the oxidative metabolism (i.e., pulmonary Vo(2) kinetics), of the bulk O(2) delivery (i.e., cardiac output), and of the rate of muscle deoxygenation (i.e., deoxygenated hemoglobin, HHb) during moderate-intensity step transitions, either with (ModB) or without (ModA) prior PE. The local matching of O(2) delivery to utilization was evaluated by the ΔHHb/ΔVo(2) ratio index. The overall speed of adjustment of the Vo(2) kinetics was significantly increased in ModB compared with ModA (P ModA (P < 0.05), suggesting an improved O(2) delivery. Our data are compatible with the hypothesis that, in older adults, PE, prior to moderate-intensity exercise, beneficially affects the speed of adjustment of oxidative metabolism due to an acute improvement of the local matching of O(2) delivery to utilization.

  18. Perforator-based fasciocutaneous flap for pressure sore reconstruction.

    Science.gov (United States)

    Lin, Chih-Hsun; Ma, Hsu

    2012-12-01

    Pressure sore reconstruction is always a challenge for plastic surgeons due to its high recurrence rate. In addition to the myocutaneous flap, the perforator-based fasciocutaneous flap has become a new entity used for pressure sore reconstruction. This study presents a series of 26 perforator-based fasciocutaneous flaps for pressure sore reconstruction, with good outcomes in 21 patients from July 2008 to April 2011. The flaps were advanced, transposed, or rotated to obliterate the defects. Twenty of 26 flaps healed uneventfully without complication. One patient had a flap that totally necrosed, one had partial flap necrosis (flap rotated 180° in the above two cases), one had infection and healed by a secondary flap, one had minor wound dehiscence, one died of pneumonia 1 week postoperatively, and recurrence developed in one patient. The perforator-based fasciocutaneous flap is a reliable method and produced good results in this series. These flaps are well vascularised, have enough soft tissue bulk, and have a high degree of mobilisation freedom.

  19. Approach to the pressure sores in geriatric patients

    Directory of Open Access Journals (Sweden)

    Emre İnözü

    2012-09-01

    Full Text Available Objectives: The aim of this study was to evaluate the follow-up results of nutritionally supported geriatric patientswho were admitted for their pressure sores then plannedtheir treatment.Materials and methods: In this study, we analyzed thehospitalized geriatric pressure sore patients in our clinicwho were admitted between 2006 and 2011. We calculatedBody Mass Index and the blood albumin levels of allhospitalized geriatric patients. In this patient group proteinenergy malnutrition and deficiency were analyzed andproper nutrition support was provided accordingly. Afterrecovering from malnutrition further treatment surpassed.Results: The mean albumin levels of the hospitalized patientswas 2,53 ± 0,25 g/dL after nutritional support thoselevels increased to mean 3,95 ± 0,42 g/dL . Of all thosepatients 75% were operated when their general conditionallowed us for a surgery. Due to their high risk wedid not perform any surgical operation to the remaining25%.. Post operative mean hospitalization period was 12(8-21 days. Majority of the patients (78.6% were treatedsuccessfully either with surgical or conservative treatmentmodalities.Conclusions: The success of the geriatric pressure soretreatment is highly related with the proper nutritional supportfor the ongoing malnutrition-like pathologies. Beforeoperation nutritional support not only makes a healthygranulation tissue but also yields fast and reliable woundhealing. Despite their chronic health problems many ofour geriatric patients were treated surgically for their pressuresores.Key words: Pressure sore, geriatric medicine, malnutrition,nutritional support

  20. Potential therapeutic effects of branched-chain amino acids supplementation on resistance exercise-based muscle damage in humans

    Directory of Open Access Journals (Sweden)

    da Luz Claudia R

    2011-12-01

    Full Text Available Abstract Branched-chain amino acids (BCAA supplementation has been considered an interesting nutritional strategy to improve skeletal muscle protein turnover in several conditions. In this context, there is evidence that resistance exercise (RE-derived biochemical markers of muscle soreness (creatine kinase (CK, aldolase, myoglobin, soreness, and functional strength may be modulated by BCAA supplementation in order to favor of muscle adaptation. However, few studies have investigated such effects in well-controlled conditions in humans. Therefore, the aim of this short report is to describe the potential therapeutic effects of BCAA supplementation on RE-based muscle damage in humans. The main point is that BCAA supplementation may decrease some biochemical markers related with muscle soreness but this does not necessarily reflect on muscle functionality.

  1. Preconditioning by light-load eccentric exercise is equally effective as low-level laser therapy in attenuating exercise-induced muscle damage in collegiate men

    Directory of Open Access Journals (Sweden)

    Nausheen S

    2017-09-01

    similar protection over time.Conclusion: This study indicated that light-load eccentric exercise confers similar protective effect against subsequent maximal eccentric exercise as LLLT. Both the treatments could be used reciprocally based on the patient preference, costs, and feasibility of the equipment. Keywords: delayed onset muscle soreness, isometric strength, elbow flexors, repeated bout effect, lactate dehydrogenase, creatine kinase

  2. Risk factors for pressure sores in adult patients with myelomeningocele – a questionnaire-based study

    Science.gov (United States)

    Plaum, Pål-Erik; Riemer, Gunnar; Frøslie, Kathrine Frey

    2006-01-01

    Background Myelomeningocele (MMC) is a part of a complex neural tube defect and a disorder of the cerebrospinal fluid system. Pressure sores are a frequent complication for patients with MMC. Little is known about the risk factors for pressure sores in adults with MMC. The aim of this study was to investigate an association between the presence of pressure sores and other patient characteristics, in order to develop an improved strategy for the management of sores. Methods A structured questionnaire regarding sores, medical condition, function and living factors was designed and sent to the 193 patients with MMC registered in the year 2003 at TRS, a National Centre for Rare Disorders in Norway. Results Out of 193 total, 87 patients participated and 71 patients (82%) reported sores; 26 (30%) at the time of the interview and 45 (52%) during the last 5 years. Sores were mostly localized on toes and feet and occurred exclusively in regions with reduced or missing sensibility. A significant association was found between sores and memory deficit (p = 0.02), Arnold Chiari malformation (p = 0.02) and a record of previous sores (p = 0.004). Sores were not significantly associated with hydrocephalus, syringomyelia, nutrition, body mass index, smoking, physical activity, employment or living together with other persons. Some patients (18, 21%) reported skin inspection by others and the remainder relied on self-inspection. Conclusion Patients with sensory deficit, memory problems, and Arnold Chiari malformation had a higher risk of having pressure sores. This patient group needs improved skin inspection routines and sore treatment. PMID:17196099

  3. Risk factors for pressure sores in adult patients with myelomeningocele – a questionnaire-based study

    Directory of Open Access Journals (Sweden)

    Frøslie Kathrine

    2006-12-01

    Full Text Available Abstract Background Myelomeningocele (MMC is a part of a complex neural tube defect and a disorder of the cerebrospinal fluid system. Pressure sores are a frequent complication for patients with MMC. Little is known about the risk factors for pressure sores in adults with MMC. The aim of this study was to investigate an association between the presence of pressure sores and other patient characteristics, in order to develop an improved strategy for the management of sores. Methods A structured questionnaire regarding sores, medical condition, function and living factors was designed and sent to the 193 patients with MMC registered in the year 2003 at TRS, a National Centre for Rare Disorders in Norway. Results Out of 193 total, 87 patients participated and 71 patients (82% reported sores; 26 (30% at the time of the interview and 45 (52% during the last 5 years. Sores were mostly localized on toes and feet and occurred exclusively in regions with reduced or missing sensibility. A significant association was found between sores and memory deficit (p = 0.02, Arnold Chiari malformation (p = 0.02 and a record of previous sores (p = 0.004. Sores were not significantly associated with hydrocephalus, syringomyelia, nutrition, body mass index, smoking, physical activity, employment or living together with other persons. Some patients (18, 21% reported skin inspection by others and the remainder relied on self-inspection. Conclusion Patients with sensory deficit, memory problems, and Arnold Chiari malformation had a higher risk of having pressure sores. This patient group needs improved skin inspection routines and sore treatment.

  4. A Study on Herbal Finish to Prevent Bed Sore Using Mangifera indica and Triphala Dried Fruit

    OpenAIRE

    Kiruthika Deivasigamani; Siva Kumar Kolandaivel; Kavitha Krishnamoorthi

    2014-01-01

    “Bed sores” owe their name to the observation that patients who were bedridden and not properly repositioned would often develop ulcerations or sores on their skin, typically over bony prominences. These bed sores, which result from prolonged pressure, are also called “decubitus ulcers,” “pressure sores,” “skin breakdown,” and “pressure ulcers.” They are associated with adverse health outcomes and high treatment costs. This study focuses on developing herbal finish to prevent bed sores. For t...

  5. Impact of laryngeal mask airway cuff pressures on the incidence of sore throat in children.

    Science.gov (United States)

    Wong, Justin Gin Leong; Heaney, Mairead; Chambers, Neil A; Erb, Thomas O; von Ungern-Sternberg, Britta S

    2009-05-01

    Hyperinflation of laryngeal mask airway cuffs can cause harm to the upper airway mainly by exerting high pressures on pharyngeal and laryngeal structures thus impairing mucosal perfusion. Although cuff manometers can be used to guide the monitoring of cuff pressures, their use is not routine in many institutions. In a prospective audit, we assessed the incidence of sore throat following day-case-surgery in relation to the intracuff pressure within the laryngeal mask airway. Four hundred children (3-21 years) were consecutively included in this study. The laryngeal mask airway was inflated as deemed necessary by the attending anesthetist. Cuff pressures were measured using a calibrated cuff manometer (Portex Limited, Hythe, Kent, UK, 0-120 cm H2O, pressures exceeding the measurement range were set at 140 cm H2O for statistical purposes) at induction of anesthesia. Forty-five children (11.25%) developed sore throat, 32 (8%) sore neck and 17 (4.25%) sore jaw. Of those that developed sore throat, 56.5% had cuff pressures exceeding >100 cm H2O. In contrast, when cuff pressures were sore throat, whilst there was only a 4.6% occurrence of sore throat if cuff pressures were between 40-60 cm H2O. We have demonstrated that intra cuff pressure in laryngeal mask airways is closely related to the development of sore throat with higher pressures increasing its likelihood. Hence, cuff pressures should be measured routinely using a manometer to minimize the incidence of sore throat.

  6. The effects of estrogen on indices of skeletal muscle tissue damage after eccentric exercise in postmenopausal women.

    Science.gov (United States)

    Dobridge, J D; Hackney, A C

    2004-01-01

    This study examined if estrogen (E) usage (in the form of hormone replacement therapy [HRT]) has a protective effect on skeletal muscle damage in postmenopausal women. Nine postmenopausal women (age 55.2 +/- 9.9 [mean +/- SD]) performed two exercise sessions at 70% of their maximal heart rate on HRT (E-HI) and without HRT (E-LO; following a 28-45 day HRT washout). All subjects followed a condition order of E-HI then E-LO with at least 42 days between exercise sessions. Serum creatine kinase (CK), perceived delayed onset muscle soreness (DOMS), and maximal quadriceps isometric force (MIF) were taken pre-exercise, 24, 48 and 72-hr post exercise. E-HI and E-LO conditions produced a rise in CK (p exercise; but CK after E-HI was greater than in E-LO (p exercise session (p exercise session (p effect to skeletal muscle; however, design limitations (i.e., condition order) confound the present data. Interestingly, an association between peak-CK during the E-LO condition and the number of washout days (r = +0.707, p effects on skeletal muscle. These findings suggest that more work correcting for the present design limitations is warranted on this topic.

  7. Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon.

    Science.gov (United States)

    Shanely, R Andrew; Nieman, David C; Zwetsloot, Kevin A; Knab, Amy M; Imagita, Hidetaka; Luo, Beibei; Davis, Barbara; Zubeldia, José M

    2014-07-01

    Adaptogens modulate intracellular signaling and increase expression of heat shock protein 72 (HSP72). Rhodiola rosea (RR) is a medicinal plant with demonstrated adaptogenic properties. The purpose of this study was to measure the influence of RR supplementation on exercise-induced muscle damage, delayed onset of muscle soreness (DOMS), plasma cytokines, and extracellular HSP72 (eHSP72) in experienced runners completing a marathon. Experienced marathon runners were randomized to RR (n=24, 6 female, 18 male) or placebo (n=24, 7 female, 17 male) groups and under double-blinded conditions ingested 600mg/day RR extract or placebo for 30days prior to, the day of, and seven days post-marathon. Blood samples were collected, and vertical jump and DOMS assessed the day before, 15min post- and 1.5h post-marathon. DOMS was also assessed for seven days post-marathon. Marathon race performance did not differ between RR and placebo groups (3.87±0.12h and 3.93±0.12h, respectively, p=0.722). Vertical jump decreased post-marathon (time effect, p0.300). In conclusion, RR supplementation (600mg/day) for 30days before running a marathon did not attenuate the post-marathon decrease in muscle function, or increases in muscle damage, DOMS, eHSP72, or plasma cytokines in experienced runners. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Influence of estrogen on markers of muscle tissue damage following eccentric exercise.

    Science.gov (United States)

    Carter, A; Dobridge, J; Hackney, A C

    2001-01-01

    This study tested the hypothesis that estrogen levels of women influences the development of a muscle-tissue damage (creatine kinase, CK) marker and delayed onset muscle soreness (DOMS) following eccentric exercise. Seventeen oral contraceptive (OC) users and ten eumenorrheic (EU) subjects completed a 30-min downhill running bout at approximately 60% VO2max. The OC completed the exercise during the mid-luteal phase (day 22.9 +/- 1.5; high estrogen) while the EU did their exercise in the mid-follicular phase (day 9.6 +/- 4.4; low estrogen) of the menstrual cycle, respectively. The CK activity and DOMS were assessed pre-exercise, immediately post-, 24, 48 and 72 h post-exercise. ANOVA results indicated that there was a significant increase in CK activity in response to the downhill run (p exercise than did the EU group. Pre-exercise estrogen levels correlated with the overall mean CK (r = -0.43, p Exercise caused an increase in DOMS in both groups (p estrogen levels have a protective effect on muscle tissue following eccentric exercise. The mechanism of this protective effect is unclear but may be related to the anti-oxidant characteristics and membrane stability properties associated with estrogen and its derivatives.

  9. Nutritional status, pressure sores, and mortality in elderly patients with cancer.

    Science.gov (United States)

    Waltman, N L; Bergstrom, N; Armstrong, N; Norvell, K; Braden, B

    1991-07-01

    This prospective study aimed to determine differences in nutritional status, incidence of pressure sores, and incidence of mortality between two groups, one composed of 33 elderly, institutionalized patients with cancer and the other a matched group of 33 patients without cancer. Subjects with cancer were paired with subjects without cancer based on age (mean = 78), sex, and pressure sore risk. Skin breakdown, dietary intake, and blood and serum indices of nutritional status were studied for 12 weeks. Of the subjects with cancer, 85% developed pressure sores, compared to 70% of the subjects without cancer. Hemoglobin (Hgb) (female), serum total protein, total lymphocyte count, serum albumin, serum total iron binding capacity, and serum transferrin were significantly lower in subjects with cancer with pressure sores than in subjects without cancer with pressure sores. Total lymphocyte count and serum total protein were significantly lower in subjects with cancer with pressure sores than in subjects with cancer without pressure sores. Kwashiorkor was found in 70% of the subjects with cancer, compared to 21% of the subjects without cancer. During the study, 39% of the subjects with cancer and 15% of the subjects without cancer died. All 13 of the subjects with cancer who died had kwashiorkor and pressure sores and had died an average of three weeks after developing pressure sores. These results implicate that elderly patients with cancer who have protein deficiencies should be considered to be at risk of pressure sore development. Frequent repositioning and mattress overlays that reduce pressure and increase comfort may delay development of pressure sores.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. Histopathology of red-sore disease (aeromonas hydrophila) in naturally and experimentally infected largemouth bass micropterus salmoides(lacepede)

    Energy Technology Data Exchange (ETDEWEB)

    Huizinga, H.W. (Illinois State Univ., Normal); Esch, G.W.; Hazen, T.C.

    1979-01-01

    The histopathology of red-sore disease, caused by the gram-negative bacterium, Aeromonas hydrophila, is described for largemouth bass, Micropterus salmoides. Externally, lesions range from those affecting a few scales (pin-point), to those associated with extensive chronic ulcerations; there is focal hemorrhage, oedema and dermal necrosis which exposes underlying muscles producing infiltration of mononuclear and granulocytic inflammatory cells. Internally, the liver and kidneys are foci for toxic products produced by A. hydrophila with, in the most severe cases, complete destruction of the structural integrity of both organs. Pathological changes were not serious in either the spleen or heart, even in cases with massive damage in the liver and kidney. Internal and external lesions were similar in both natural and experimentally induced infections. The pathobiology of red-sore disease in bass was postulated to be linked to elevated water temperature stimulating increased metabolism, decreased body condition and stress, leading to the increased production of corticosteroids and the concommitant rise in susceptibility to infection.

  11. Effects of a High Protein and Omega-3-Enriched Diet with or Without Creatine Supplementation on Markers of Soreness and Inflammation During 5 Consecutive Days of High Volume Resistance Exercise in Females

    Science.gov (United States)

    Hayward, Sara; Wilborn, Colin D.; Taylor, Lem W.; Urbina, Stacie L.; Outlaw, Jordan J.; Foster, Cliffa A.; Roberts, Michael D.

    2016-01-01

    We examined if two different dietary interventions affected markers of soreness and inflammation over a 5-day high-volume resistance training protocol in females that resistance-trained 8 weeks prior. Twenty-eight females (age: 20 ± 1 yr; body mass: 63.5 ± 1.6 kg, height: 1.67 ± 0.01 m) completed 4 weeks of pre-training (weeks 1-4) followed by a subsequent 4-week training period along with a dietary intervention (weeks 5-8). Dietary interventions from weeks 5-8 included: a) no intervention (CTL, n = 10) b) a higher-protein diet supplemented with hydrolyzed whey protein (50 g/d) and omega-3 fatty acids (900 mg/d) (DI, n = 8), and c) the DI condition as well as creatine monohydrate (5 g/d) (DI+C, n = 10). During week 9, participants resistance-trained for five consecutive days whereby 8 sets of 10 target repetitions at 70% one repetition maximum (1RM) were performed each day for bench press, back squat, deadlift, and hip-thrusters with the intent of eliciting muscle soreness and inflammation. Prior to and 24 h following each of the 5 bouts muscle soreness (DOMS) was assessed via questionnaire, and fasting blood was obtained and analyzed for serum cortisol, interleukin-6 (IL-6) and C-reactive protein (CRP). No group*time (G*T) or time effects were observed for training volume over the 5-d overreaching protocol. Furthermore, no group*time (G*T) or time effects were observed for serum cortisol, IL-6 or CRP, and DOMS actually decreased in all groups 24 h following the fifth day training bout. This study demonstrates that, regardless of protein, omega-3 fatty acid and/or creatine supplementation, 5 days of consecutive resistance training does not alter perceived muscle soreness, training volume, and/or markers of inflammation in novice resistance-trained females. Key points We examined if two different dietary interventions (higher protein and omega-3 supplementation, or higher protein and omega-3 supplementation with creatine supplementation) affected muscle soreness

  12. Cost analysis of surgically treated pressure sores stage III and IV.

    NARCIS (Netherlands)

    Filius, A.; Damen, T.H.; Schuijer-Maaskant, K.P.; Polinder, S.; Hovius, S.E.; Walbeehm, E.T.

    2013-01-01

    Health-care costs associated with pressure sores are significant and their financial burden is likely to increase even further. The aim of this study was to analyse the direct medical costs of hospital care for surgical treatment of pressure sores stage III and IV. We performed a retrospective chart

  13. Cold sore susceptibility gene-1 genotypes affect the expression of herpes labialis in unrelated human subjects.

    Science.gov (United States)

    Kriesel, John D; Bhatia, Amiteshwar; Thomas, Alun

    2014-01-01

    Our group has recently described a gene on human chromosome 21, the Cold Sore Susceptibility Gene-1 (CSSG-1, also known as C21orf91), which may confer susceptibility to frequent cold sores in humans. We present here a genotype-phenotype analysis of CSSG-1 in a new, unrelated human population. Seven hundred fifty-eight human subjects were enrolled in a case/control Cold Sore Study. CSSG-1 genotyping, herpes simplex virus 1 (HSV1) serotyping, demographic and phenotypic data was available from 622 analyzed subjects. Six major alleles (H1-H6) were tested for associations with each of the self-reported phenotypes. The statistical analysis was adjusted for age, sex and ethnicity. Genotype-phenotype associations were analyzed from 388 HSV1-seropositive subjects. There were significant CSSG-1 haplotype effects on annual cold sore outbreaks (P=0.006), lifetime cold sores (P=0.012) and perceived cold sore severity (P=0.012). There were relatively consistent trends toward protection from frequent and severe cold sores among those with the H3 or H5/6 haplotypes, whereas those with H1, H2, and H4 haplotypes tended to have more frequent and more severe episodes. Different alleles of the newly described gene CSSG-1 affect the expression of cold sore phenotypes in this new, unrelated human population, confirming the findings of the previous family-based study.

  14. Cost analysis of surgically treated pressure sores stage III and IV.

    NARCIS (Netherlands)

    Filius, A.; Damen, T.H.; Schuijer-Maaskant, K.P.; Polinder, S.; Hovius, S.E.; Walbeehm, E.T.

    2013-01-01

    Health-care costs associated with pressure sores are significant and their financial burden is likely to increase even further. The aim of this study was to analyse the direct medical costs of hospital care for surgical treatment of pressure sores stage III and IV. We performed a retrospective chart

  15. Decubitus grade IV (deep pressure sore) with intact skin in a patient with spinal cord injury

    NARCIS (Netherlands)

    Theunissen, C.C.W.; Zeilstra, J.T.; van Voorst Vader, P.C.; Kardaun, S.H.; Leeman, F.W.J.

    2006-01-01

    Even with intact skin the possibility of pressure sores should not be dismissed. Early recognition of a pressure sore is important for adequate treatment and prevention of progression. Multidisciplinary intervention is essential. A wheelchair patient with spinal cord injury is described, who develop

  16. Randomized clinical study comparing Compeed (R) cold sore patch to acyclovir cream 5% in the treatment of herpes simplex labialis

    DEFF Research Database (Denmark)

    Karlsmark, T.; Goodman, J.J.; Drouault, Y.

    2008-01-01

    Background Hydrocolloid technology has been proven effective in treating dermal wounds. A previous study showed that a newly developed thin hydrocolloid patch [Compeed (R) cold sore patch (CSP)] provided multiple wound-healing benefits across all stages of a herpes simplex labialis (HSL) outbreak......) at the onset of symptoms until the lesion healed, for a maximum of 10 days. The primary end point was the subject's global assessment of therapy (SGAT; 0-10 scale; 0 = no response, 10 = excellent response). Multiple secondary end points included clinician-assessed healing time and subject assessment of lesion...... protection, noticeability and social embarrassment. Results CSP and acyclovir were highly effective (mean SGAT = 7.89 and 8.00, respectively), with no significant difference observed (P = 0.65). The difference in healing times between products was not significant (median, 7.57 days with CSP vs. 7.03 days...

  17. Effect of acupuncture depth on muscle pain

    Directory of Open Access Journals (Sweden)

    Kitakoji Hiroshi

    2011-06-01

    Full Text Available Abstract Background While evidence supports efficacy of acupuncture and/or dry needling in treating musculoskeletal pain, it is unclear which needling method is most effective. This study aims to determine the effects of depth of needle penetration on muscle pain. Methods A total of 22 healthy volunteers performed repeated eccentric contractions to induce muscle soreness in their extensor digital muscle. Subjects were assigned randomly to four groups, namely control group, skin group (depth of 3 mm: the extensor digital muscle, muscle group (depth of 10 mm: the extensor digital muscle and non-segmental group (depth of 10 mm: the anterior tibial muscle. Pressure pain threshold and electrical pain threshold of the skin, fascia and muscle were measured at a point 20 mm distal to the maximum tender point on the second day after the exercise. Results Pressure pain thresholds of skin group (depth of 3 mm: the extensor digital muscle and muscle group (depth of 10 mm: the extensor digital muscle were significantly higher than the control group, whereas the electrical pain threshold at fascia of muscle group (depth of 10 mm: the extensor digital muscle was a significantly higher than control group; however, there was no significant difference between the control and other groups. Conclusion The present study shows that acupuncture stimulation of muscle increases the PPT and EPT of fascia. The depth of needle penetration is important for the relief of muscle pain.

  18. The Braden Scale for Predicting Pressure Sore Risk.

    Science.gov (United States)

    Bergstrom, N; Braden, B J; Laguzza, A; Holman, V

    1987-01-01

    The Braden Scale for Predicting Pressure Sore Risk was developed to foster early identification of patients at risk for forming pressure sores. The scale is composed of six subscales that reflect sensory perception, skin moisture, activity, mobility, friction and shear, and nutritional status. Content and construct validity were established by expert opinion and empirical testing. Three studies of reliability are reported here, using raters who varied in level of educational preparation and geographic region. Two prospective studies of predictive validity were completed to determine the scale's sensitivity and specificity. Reliability ranged from r = .83 to r = .94 for nurses' aides and licensed practical nurses; when used by registered nurses, the reliability increased to r = .99. Predictive validity was calculated for each cut-off point of the scale. Using a cut-off point of 16, sensitivity was 100% in both studies. Specificity ranged from 64% to 90%. This instrument has highly satisfactory reliability when used by RNs, and greater sensitivity and specificity than instruments previously reported.

  19. Rational decision making based on history: adult sore throats.

    Science.gov (United States)

    Clancy, C M; Centor, R M; Campbell, M S; Dalton, H P

    1988-01-01

    Primary care physicians are often required to make preliminary evaluations based only on the patient's history, especially during telephone encounters about sore throats. The authors studied adults with sore throats to determine whether patients can be stratified into higher and lower risks of strep throat by history alone. They first obtained data from 517 patients seen in an emergency room. Providers graded symptoms on a four-point scale (absent, mild, moderate, or severe). Initial analyses showed that prediction based on history should include three variables: fever, difficulty in swallowing, and cough. For ease of computation, these were consolidated into one score, "history" (= fever history + difficulty in swallowing - cough). This score was used to develop a model that predicts the probability of infection with group A beta-hemolytic streptococcus, and the model's performance was tested in two additional patient groups. The predictive accuracy of the "history" score was confirmed in all patient groups, despite differences in providers and disease prevalences. Primary care physicians may use this model to help them make decisions in situations such as telephone encounters without using additional data.

  20. The effect of ketamine on sore throat after tonsillectomy

    Directory of Open Access Journals (Sweden)

    M. Haghighi

    2007-01-01

    Full Text Available AbstractBackground and purpose: Ketamine efficacy as an analgesic adjuvant has been studied in several clinical settings with conflicting results. Sore throat and pain after swallowing following tonsillectomy is significant. The aim of this study was to investigate the effect of ketamine on sore throat (pain after tonsillectomy.Materials and Methods: In this double blind clinical trial, fifty children were, divided in to two equal groups of Ketamine and control. The subjects aged 4-14 years old and physical ASA class I-II were randomized to receive pemedication with either ketamine 0.1mg/kg I.V. or placebo 5 minutes before induction of a standard general anesthesia.Results: The ketamine group showed significantly lower pain scores with less total pethidine consumption (P<0.005 during 6h after surgery. The mean pain score in ketamine group was 1.32 and in control group was 2.4 . There were no differences in the incidence of vomiting between the groups.Conclusion: Premedication with a small dose of ketamine reduces pain after tonsillectomy in children who received an analgesic regimen combined with an opoid.

  1. [Resurfacing of an ischial and trochanteric recurrent pressure sore by a pedicled fasciocutaneous anterolateral thigh flap].

    Science.gov (United States)

    Moullot, P; Philandrianos, C; Casanova, D

    2014-10-01

    Ischial pressure sores, common in paraplegic patient, are the most difficult to treat, and poor prognosis associated with a high rate of postoperative recurrence. Many surgical techniques by muscular or myocutaneous flap coverage have been described. We report an original use of a fasciocutaneous pedicled anterolateral thigh (ALTp) flap for coverage of an ischial pressure sore combined with a trochanteric pressure sore, exceeded beyond any conventional therapeutic solution. A 45-year-old paraplegic patient suffered from a trochanteric and ischial pressure sore, which had already received coverage by a muscular flap of biceps femoris and gluteus maximus. At 1 year, the result is satisfactory, with good coverage without recurrence. The fasciocutaneous ALTp flap can be a solution to cover recurrent ischial pressure sores beyond conventional methods. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  2. Início da atividade elétrica dos músculos estabilizadores da patela em indivíduos com SDPF Onset of electrical activity of patellar stabilizer muscles in subjects with patellofemoral pain

    Directory of Open Access Journals (Sweden)

    Débora Bevilaqua-Grossi

    2009-01-01

    Full Text Available OBJETIVO: Avaliar a porcentagem de disparo inicial (PDI dos músculos estabilizadores da patela durante exercícios de contração isométrica voluntária máxima (CIVM em indivíduos com e sem sinais da síndrome da dor patelofemural (SDPF nos exercícios de cadeia cinética aberta (CCA e fechada (CCF. MÉTODO: Foram avaliadas 10 mulheres sem queixa de dor anterior no joelho e 12 mulheres com sinais de SDPF durante a CIM em CCA e CCF com o joelho posicionado a 90º de flexão do joelho. O início da atividade eletromiográfica dos músculos vasto medial obliquo (VMO, vasto lateral obliquo (VLO e vasto lateral longo (VLL foi identificada por meio de um algoritmo no programa Myosystem Br 1. A análise estatística empregada foi o teste Qui-Quadrado e o teste t de student, ambos os teste com nível de significância de 5%. RESULTADOS: Os músculos VMO e VLO apresentaram uma maior PDI em relação ao músculo VLL durante os exercícios em CCA para ambos os grupo e para o grupo SDPF em CCF. Não foi observado diferença entre os grupos. CONCLUSÃO: Pode-se sugerir que tanto os exercícios em CCA quanto em CCF, parecem beneficiar o sincronismo na musculatura estabilizadora da patela, podendo ser indicado nos programas de tratamento fisioterapêutico.OBJECTIVE: To asses the onset (% of patella stabilizer muscles during maximal isometric contraction exercises (MIC in individuals with and without signs of patellofemoral pain syndrome (PFPS in open (OKC and closed (CKC kinetic chain exercises. METHOD: Assessments were carried out on 22 women; ten with no complains of anterior knee pain, and 12 with PFPS signs during MIC in OKC and CKC with the knee flexed at 90º. The onset of the electromyographic activity of the vastus mediallis obliquus (VMO, vastus lateralis obliquus (VLO and vastus lateralis longus (VLL was identified by means of an algorithm in the Myosystem Br 1 software. The statistical analysis used was Chi-Square test and student's t test

  3. No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra-runners - a randomized controlled trial

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    Rosemann Thomas

    2011-04-01

    Full Text Available Abstract Background The purpose of this study was to investigate the effect of short-term supplementation of amino acids before and during a 100 km ultra-marathon on variables of skeletal muscle damage and muscle soreness. We hypothesized that the supplementation of amino acids before and during an ultra-marathon would lead to a reduction in the variables of skeletal muscle damage, a decrease in muscle soreness and an improved performance. Methods Twenty-eight experienced male ultra-runners were divided into two groups, one with amino acid supplementation and the other as a control group. The amino acid group was supplemented a total of 52.5 g of an amino acid concentrate before and during the 100 km ultra-marathon. Pre- and post-race, creatine kinase, urea and myoglobin were determined. At the same time, the athletes were asked for subjective feelings of muscle soreness. Results Race time was not different between the groups when controlled for personal best time in a 100 km ultra-marathon. The increases in creatine kinase, urea and myoglobin were not different in both groups. Subjective feelings of skeletal muscle soreness were not different between the groups. Conclusions We concluded that short-term supplementation of amino acids before and during a 100 km ultra-marathon had no effect on variables of skeletal muscle damage and muscle soreness.

  4. Sepsis of the hip due to pressure sore in spinal cord injured patients: advocacy for a one-stage surgical procedure.

    Science.gov (United States)

    Le Fort, M; Rome-Saulnier, J; Lejeune, F; Bellier-Waast, F; Touchais, S; Kieny, P; Duteille, F; Perrouin-Verbe, B

    2014-11-04

    Study design:Retrospective study reporting characteristics and management of septic arthritis of the hip due to pressure sores in spinal cord-injured patients.Objectives:To describe clinical and biological data of septic arthritis of the hip and its treating management.Setting:The database of the regional SCI referral center, Nantes, France.Methods:We retrospectively collected data from 33 cases of septic arthritis of the hip in the medical files of 26 patients.Results:We analyzed 33 cases of septic arthritis of the hip treated in one French referent center for spinal cord-injured patients from January 1988 to December 2009. Most patients had a thoracic complete paraplegia and nearly two-third (17 out of 26) had no systematic follow-up. In 25 out of 33 cases, the septic arthritis of the hip was due to a trochanteric pressure sore. The causal pressure sore was most frequently associated with a persistent drainage. The standard radiological examination led to the diagnosis in 30 cases and, in 7 questionable cases, magnetic resonance imaging was more contributory. Surgery always consisted of a wide carcinological-like excision and of a subtrochanteric proximal femoral resection including both greater and lesser trochanters. A musculocutaneous flap was realized for all cases and the choice of the muscle depended on the localization of the causal pressure sore but also of the remaining choices, as most of the patients had already undergone a prior surgery. An antibiotic treatment was adapted to multiple samples during surgery.Conclusion:We do advocate for a one-stage procedure including a subtrochanteric proximal femoral resection and a musculocutaneous flap.Spinal Cord advance online publication, 4 November 2014; doi:10.1038/sc.2014.170.

  5. Causes of sore throat after intubation: a prospective observational study of multiple anesthesia variables.

    Science.gov (United States)

    Levin, Phillip D; Chrysostomos, Chrysostomou; Ibarra, Carlos A; Ledot, Stephan; Naito, Daigo; Weissman, Charles; Avidan, Alexander

    2017-06-01

    Sore throat is common after intubation for surgery. This observational study investigated cuff pressure and a large range of clinical covariates to explore the etiology of sore throat. Approximately 24 hours after surgery six questions relating to pain, upper airway symptoms and sore throat were delivered to patients who had undergone intubation. Sore throat was correlated with demographics, anesthesia variables and cuff pressure (measured for a subset of patients). Sore throat was reported by 270/518 (52%) patients with VAS Score 45.9±25.1 (range 0-100). Sore throat patients were significantly younger, had a lower ASA status, were more frequently female, had shorter surgeries and lower nitrous oxide exposure, had a higher proportion of smaller tracheal tubes (7.5 mm internal diameter vs. 8 mm), had a higher incidence of nasogastric drainage, higher propofol doses and a higher usage of ketorolac. Decreasing age (odds ratio 0.976, 95% confidence intervals 0.961-0.992, P=0.003) and the presence of a nasogastric tube when the questionnaire was delivered (OR 1.83, 95% CI: 1.06-3.14, P=0.03) remained significant predictors of sore throat on multivariate analysis. Mean cuff pressure (measured for 160 patients) was 56.8±41.9 mmHg. Cuff pressure was similar amongst patients with and without sore throat (57±46 vs. 53±38 mmHg, P=0.58). There was no correlation between cuff pressure and severity of sore throat (r=0.004, P=0.37). Only age and the presence of a nasogastric tube after surgery were significant predictors for sore throat. This result contradicts most other studies of cuff pressure where fewer covariates were measured.

  6. Randomized controlled trials on the influence and mechanism of manipulation on delayed onset muscle soreness after eccentric exercise%推拿对一次性离心运动后延迟性肌肉酸痛影响及机制的随机对照试验

    Institute of Scientific and Technical Information of China (English)

    熊英; 吴云川; 金宏柱; 顾一煌

    2009-01-01

    目的:观察比较运动前、后推拿及自然恢复对一次性离心运动所致延迟性肌肉酸痛(DOMS)的影响,并从氧自由基代谢方面时推拿的作用机制进行探讨.方法:本研究地点为南京中医药大学,时间2008年4-7月.将30名健康男性学生按照条件对等原则随机分成运动前推拿组(A)、运动后推拿组(B)和对照组(自然恢复组,即C组),每组各10名.A组学生于训练前在左上肢进行30 min推拿,推拿结束5 min后开始训练;B组学生于训练后30 min在左上肢进行30 min推拿,并在此后的3 d内按规定时间继续接受推拿治疗,每次30 min,每日1次.C组学生仅参加训练,不做任何的准备活动或整理活动,也不接受任何治疗.分别于训练前、训练后即刻及训练后24、48、72 h测定肌肉酸痛程度和持续时间、肌肉最大等长收缩力量、臂围、肘关节的屈伸度.血清肌酸激酶(CK)、血清超氧化物歧化酶(SOD)、血清丙二醛(MDA)测定安排在训练前1 h、训练后即刻及训练后24、48 h.同时观察酸痛消失的具体时间.结果:与C组相比,A组和B组酸痛峰值均降低(P<0.01,P<0.05);运动后72 h肘关节屈曲程度的恢复优于C组(P<0.05,P<0.01);运动后48 h的血清CK升高幅度低于C组(P<0.01).A组肌肉酸痛持续时间缩短(P<0.01),运动后72 h肌内最大等长收缩力量的恢复优于C组(P<0.01);B组在运动后72 h的肘关节伸直程度的恢复优于C组(P<0.01).A、B组的臂围变化与对照组无明显差异.A、B组在运动后48 h时的血清SOD、MDA和SOD/MDA变化程度与C组差异均有统计学意义(P<0.01或0.05).结论:运动前、后推拿能通过改善DOMS过程中氧自由基的代谢水平而分别对DOMS具有一定的预防和治疗作用.

  7. 本体感神经肌肉易化牵伸与斜刺阿是穴治疗小腿三头肌延迟性肌肉酸痛症的效果比较%Proprioceptive neuromuscular facilitation stretching versus puncturing Ashi point for delayed-onset muscle soreness in triceps surae

    Institute of Scientific and Technical Information of China (English)

    王小迪; 张保国; 王安利

    2006-01-01

    目的:对比观察本体感神经肌肉易化法牵伸、斜刺阿是穴对一次大强度力竭离心运动所致延迟性肌肉酸痛的治疗作用.方法:①于2006-05/06选择山东理工大学体育学院学生30人,均为健康男性,且对治疗方案知情同意.按照条件对等原则随机分为3组:牵伸组、斜刺组和对照组,每组10人.②让受试者先做5组原地蛙跳共60个,然后在跑台上沿-15°斜坡以10 km/h跑速跑至力竭造成延迟性肌肉酸痛.第1次治疗时间均为力竭跑后即刻,而后每隔24h治疗1次,共进行4次.牵伸组:先做5 min的准备活动,再做10min的小腿三头肌本体感神经肌肉易化牵伸练习,然后使用"收缩-放松-向相反方向牵伸法".斜刺组:在小腿三头肌用28号3寸毫针在沿此束肌肉长轴距最痛点适当距离处垂直进针,针尖进入皮下疏松结缔组织层时调整进针角度向痛点斜向刺入.在有明显的酸胀感觉时留针3~15 min,不提插捻转,当针感消失或明显缓解后即可出针.对照组:进行15 min的基本活动:先做5 min慢跑,再进行10 min专项基本活动.③于运动前安静时和运动后24,48,72 h先采用美国RT-1904C型半自动化分析仪检测血清磷酸激酶活性;再按照测量血压的方法,记录当触压到小腿三头肌感到酸痛的程度时,看水银压力计对应的刻度,作为受试者的主观酸痛感觉阈.压力越小表示主观察酸痛感觉越明显.全部选取右腿进行测试.最后记录每个学生的原地纵跳摸高高度值(做3次,记录最高值),反映小腿三头肌的肌力强弱.运动后测试于当天做完相应治疗措施后进行.④计量资料差异性比较,组内采用配对t检验,组间采用t检验.对血清肌酸激酶和主观酸痛感觉阈值进行Pearson相关分析.结果:学生30人均进入结果分析.①血清肌酸激酶活性(反映受损肌肉恢复程度):牵伸组、斜刺组运动员运动后48和72 h均明显低于对照组(t=3.25~4.31,P<0.01),且运动后72 h已经下降至接近安静时(P>0.05),牵伸组、斜刺组间比较,差异不明显(P>0.05).对照组在运动后各时间段均明显高于安静时(t=4.80~10.62,P<0.01).②主观酸痛感觉阈:牵伸组和斜刺组运动后各时段均明显高于对照组(t=2.63~4.19,P<0.05~0.01),两组各时段差异不明显(P>0.05);牵伸组和斜刺组只在运动后72 h接近安静时(P>0.05),而对照组在运动后各时间段均明显低于安静时(t--4.43~16.61,P<0.01).③纵跳摸高高度值(反映小腿三头肌肌力):斜刺组运动后24 h明显高于对照组(t=3.28,P<0.01);牵伸组与对照组相近,两组均明显低于安静时(t=2.48,3.55,P<0.01).④血清肌酸激酶活性与主观酸痛感觉阈的相关性:运动后48和72 h的血清肌酸激酶活性与除安静时各时段主观酸痛感觉阈呈显著负相关(r=-0.443~0.487,P<0.05~0.01).结论:①本体感神经肌肉易化法牵伸和斜刺均可以明显加快运动员受损肌肉的恢复、降低主观酸痛感觉.②斜刺阿是穴提高运动员肌力的效果优于本体感神经肌肉易化法牵伸,特别是运动后24 h.③在一次大强度离心力竭跑后48和72 h,血清肌酸激酶活性变化与主观酸痛感觉有关,而在运动后24 h内两者无明显相关性.

  8. Efficacy of epicutaneous Diractin® (ketoprofen in Transfersome® gel for the treatment of pain related to eccentric muscle contractions

    Directory of Open Access Journals (Sweden)

    Matthias Rother

    2009-05-01

    ®, epicutaneous application, eccentric muscle contraction, delayed onset muscle soreness

  9. [The Development of a Care Protocol for Postoperative Pressure Sore Prevention].

    Science.gov (United States)

    Huang, Yu-Ling; Lin, Hui-Ling; Wang, Fang; Wu, Shu-Fang Vivienne

    2015-12-01

    Pressure sores are a common complication caused by long periods of bed rest following major surgery. These sores may increase patient postoperative pain, increase the risk of infections, lengthen the pe-riod of hospitalization, and increase the duration and costs of nursing care. Therefore, maintaining the skin integrity of surgical patients is an important responsibility for operating room nurses and an indicator of nursing care quality. While pressure-sore risk assessment tools and interoperative strategies are available and used in foreign countries, there has been little related research conducted in Taiwan. After examining the relevant literature and considering the current postoperative pressure sore situation in Taiwan, the author developed a postoperative pressure sore care protocol as a reference for clinical staff. Protocol procedures include major breakthrough developments in areas such as post-survey risk assessment for pressure ulcers, pressure ulcer prevention strategies that take surgery-related risk factors into consideration, extra care and protection measures for surgical supine patients, and post-pressure sores. The developed postoperative pressure sore protocol may be incorporated into surgical care procedures during the post-surgical care period in order to effectively prevent the occurrence of post-surgery pressure ulcers. Furthermore, the developed protocol offers the potential to improve and strengthen the quality of surgical care in terms of both healthcare and post-surgical care.

  10. Total bed management: the way forward in pressure sore prevention.

    Science.gov (United States)

    Preece, J

    King's College Hospital, London, is the first trust to implement total bed management (TBM) to assist in the reduction and prevention of pressure sores. TBM is a new concept, whereby the tissue viability, manual handling and therapy needs of the trust are met at reduced costs through a partnership with a contractor. The introduction of a large number of electric bed frames and foam mattress replacements, with the availability of dynamic pressure-relieving equipment and a service agreement, has led to an expected trust saving of 86,000 Pounds in 1998/1999 and 100,000 Pounds in 1999/2000 onwards. This article outlines the perceived benefits of this approach.

  11. The effects of adding leucine to pre and postexercise carbohydrate beverages on acute muscle recovery from resistance training.

    Science.gov (United States)

    Stock, Matt S; Young, John C; Golding, Lawrence A; Kruskall, Laura J; Tandy, Richard D; Conway-Klaassen, Janice M; Beck, Travis W

    2010-08-01

    The present study examined the effects of adding leucine to pre and postexercise carbohydrate beverages on selected markers of muscle damage, delayed-onset muscle soreness (DOMS), and squat performance for up to 72 hours after lower-body resistance training. Seventeen resistance trained men (mean +/- SD age 22.9 +/- 2.9 years) and 3 resistance trained women (mean +/- SD age 21.6 +/- 2.6 years) performed 6 sets of squats to fatigue using 75% of the 1 repetition maximum. Each subject consumed a carbohydrate beverage 30 minutes before and immediately after exercise with or without the addition of 22.5 mgxkg (45 mgxkg total) of leucine in a randomized, double-blind fashion. Serum creatine kinase (CK), lactate dehydrogenase (LDH), and DOMS were analyzed immediately before (TIME1), 24 (TIME2), 48 (TIME3), and 72 (TIME4) hours after exercise. The subjects repeated the squat protocol at TIME4 to test recovery. No differences were observed between groups for squat performance, defined as the total number of repetitions performed during 6 sets of squats, for both TIME1 and TIME4. The addition of leucine did not significantly decrease CK and LDH activity or DOMS. These results suggested that adding leucine to carbohydrate beverages did not affect acute muscle recovery and squat performance during both initial testing and during a subsequent exercise bout 72 hours later in resistance trained subjects.

  12. [Sore throat and chronic tonsillitis (an analytical review)].

    Science.gov (United States)

    Chistiakova, V P

    2012-01-01

    This communication is designed to overview the literature publications concerning sore throat and chronic tonsillitis that appeared during the period from 2007 to 2011. It is shown that the prevalence of chronic tonsillar pathology tends to grow progressively over time and is presently 1.5-1.8 times higher than it was in the 1970s. The incidence of newly diagnosed cases of tonsillitis increases even at a higher rate. The total morbidity in the regions characterized by a high level of environmental pollution exceeds by a factor of 2.1 that in the areas with the relatively more friendly environment. Due to the reduction in the proportion of surgical interventions in the general strategy of treatment of sore throat and chronic tonsillitis, even in the presence of medical indications, a three-fold rise in the frequency of local pyoinflammatory tonsillogenic complications is documented. New techniques for diagnostics of tonsillogenic intoxication allowing to better estimate the severity of decompensation with a higher degree of accuracy are considered. It is emphasized that physical methods, such as ultrasound, laser, cryogenic,ultraviolet, and magnetic therapy in combination with antiseptic drugs, find the increasingly wider application along with immunomodulatory, antibacterial, antiviral, and antifungal agents for conservative therapy based on the differential choice of medicamental preparations. Equally widely used are novel surgical methods for the management of chronic tonsillitis including modern variants of peritonsillar tissue dissection techniques based on the application of electric current, radiowaves, laser and ultrasound radiation, cryogenic factors and cold-plasma, etc. The use of these tools facilitates the surgical intervention and helps to prevent postoperative complications.

  13. Characteristics of children consulting for cough, sore throat, or earache

    Science.gov (United States)

    Uijen, Johannes HJM; van Duijn, Huug J; Kuyvenhoven, Marijke M; Schellevis, François G; van der Wouden, Johannes C

    2008-01-01

    Background GPs are often consulted for respiratory tract symptoms in children. Aim To explore characteristics of children, their parents, and their GPs that are correlated with consulting a GP for cough, sore throat, or earache. Design of study Second Dutch National Survey of General Practice (DNSGP-2) with a health interview and an additional questionnaire. Setting Children aged 0–17 years registered with 122 GPs in Dutch general practice. Method Characteristics of patients and their GPs were derived from the DNSGP-2 health interview and a questionnaire, respectively. Characteristics of the illness symptoms and GP consultation were acquired by means of an additional questionnaire. Data were analysed using multivariate logistic regression. Results Of all children who completed the questionnaire, 550 reported cough, sore throat, or earache in the 2 weeks preceding the interview with 147 of them consulting their GP. Young children more frequently consulted the GP for respiratory symptoms, as did children with fever, longer duration of symptoms, those reporting their health to be ‘poor to good’, and living in an urban area. When parents were worried, and when a child or their parents were cued by someone else, the GP was also consulted more often. GP-related determinants were not associated with GP consultation by children. Conclusion This study emphasises the importance of establishing the reasons behind children with respiratory tract symptoms consulting their GP. When GPs are aware of possible determinants of the decision to consult a GP, more appropriate advice and reassurance can be given regarding these respiratory symptoms, which are generally self-limiting. PMID:18387228

  14. Study regarding the effect of calendula officinalis cream in healing of pressure sores

    Directory of Open Access Journals (Sweden)

    Ravanbakhsh Esmaili

    2008-01-01

    Full Text Available (Received 13 July, 2008 ; Accepted 29 Oct, 2008 Abstract Background and Purpose: Pressure sore is common among patients with prolonged stay in hospitals or homes. Treatment of such sores is costly and performed by various procedures. Considering the effective role of calendula officinalis in treatment of sores, ulcers and cutaneous inflammations, this study is conducted to determine the effect of this cream in healing pressure sores.Materials and methods: This is a pre/post comparative clinical trial done on 20 patients with pressure sores who received the recommended treatment.The condition of patients such as, duration of pressure sore, and the extent of the sore were recorded. The sore was washed with normal saline, dried, followed by applying calendula cream three times a day for a duration of 4 weeks. Each week, the extent and rate of healing was observed and recorded.Results: The rate of healing in patients under our study was 56.6%. Majority (55% of patients had partial healing. The time of healing was in weeks 3.5±1.2 (P<0.001. The complete healing occurred in the 3rd and 4th week, subsequent to the beginning of the treatment.Conclusion: Considering the availability of the cream and its affordability, it can be used in the treatment of pressure sores. In addition, it can be used as a drug for treatment of patients who are in hospitals and/or in their homes. J Mazand Univ Med Sci 2008; 18(66:19-25(Persian

  15. Ischemic Compression After Dry Needling of a Latent Myofascial Trigger Point Reduces Postneedling Soreness Intensity and Duration.

    Science.gov (United States)

    Martín-Pintado-Zugasti, Aitor; Pecos-Martin, Daniel; Rodríguez-Fernández, Ángel Luis; Alguacil-Diego, Isabel María; Portillo-Aceituno, Alicia; Gallego-Izquierdo, Tomás; Fernandez-Carnero, Josue

    2015-10-01

    To investigate the effect of ischemic compression (IC) versus placebo and control on reducing postneedling soreness of 1 latent myofascial trigger point and on improving cervical range of motion (CROM) in asymptomatic subjects. A randomized, double-blind, placebo-controlled trial with 72-hour follow-up. A university community. Asymptomatic volunteers (N = 90: 40 men and 50 women) aged 18 to 39 years (mean ± standard deviation [SD]: 22 ± 3 years). All subjects received a dry needling application over the upper trapezius muscle. Participants were then randomly divided into 3 groups: a treatment group who received IC over the needled trapezius muscle, a placebo group who received sham IC, and a control group who did not receive any treatment after needling. Visual analog scale (VAS; during needling, at posttreatment and 6, 12, 24, 48, and 72 hours) and CROM (at preneedling, postneedling, and 24 and 72 hours). Subjects in the IC group showed significantly lower postneedling soreness than the placebo and the control group subjects immediately after treatment (mean ± standard deviation [SD]: IC, 20.1 ± 4.8; placebo, 36.7 ± 4.8; control, 34.8 ± 3.6) and at 48 hours (mean ± SD: IC, 0.6 ± 1; placebo, 4.8 ± 1; control, 3.8 ± 0.7). In addition, subjects in the dry needling+IC group showed significantly lower postneedling soreness duration (P = .026). All subjects significantly improved CROM in contralateral lateroflexion and both homolateral and contralateral rotations, but only the improvements found in the IC group reached the minimal detectable change. IC can potentially be added immediately after dry needling of myofascial trigger point in the upper trapezius muscle because it has the effect of reducing postneedling soreness intensity and duration. The combination of dry needling and IC seems to improve CROM in homolateral and contralateral cervical rotation movements. Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by

  16. A comparative analysis of pressure sore treatment modalities in community settings

    Directory of Open Access Journals (Sweden)

    N. Small

    2002-09-01

    Full Text Available The management of pressure sores in community settings, poses a clinical problem which challenges the patient’s tolerance and the clinician’s diligence and ingenuity. Pressure sores can be painful, lead to infection and are associated with considerable morbidity and increased mortality (Patterson & Bennett, 1995:919; Bale, Banks, Hagelstein & Harding, 1998:65. Treatment costs of these wounds are high in terms of resources (Colin 1995:65; Wood, Griffiths & Stoner, 1997:256. However, since there are untold cost in terms of pain and suffering to the patient, it is impossible to calculate the true cost of pressure sores (Dealey, 1994:87.

  17. Sacral pressure sore reconstruction -- the pedicled superior gluteal artery perforator flap.

    Science.gov (United States)

    Hurbungs, A; Ramkalawan, H

    2012-02-14

    To report the use of the pedicled superior gluteal artery perforator (SGAP) fasciocutaneous flap as a reliable surgical option for sacral pressure sore reconstruction. A prospective study was conducted between September 2008 and September 2010 of 10 patients with stage 3 or 4 sacral pressure sores treated with a unilateral pedicled SGAP flap. All flaps survived completely with no complications in 9 patients. One patient had a haematoma below the flap that was easily drained. No recurrence of the bedsore occurred during follow-up. We suggest that the pedicled SGAP fasciocutaneous flap is a reliable surgical option for sacral pressure sore reconstruction.

  18. Surface Electromyography Assessments of the Vastus medialis and Rectus femoris Muscles and Creatine Kinase after Eccentric Contraction Following Glutamine Supplementation.

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    Rahmani-Nia, Farhad; Farzaneh, Esmail; Damirchi, Arsalan; Majlan, Ali Shamsi; Tadibi, Vahid

    2014-03-01

    L-glutamine is the most abundant amino acid found in human muscle and plays an important role in protein synthesis and can reduce the levels of inflammation biomarkers and creatine kinase (CK) after training sessions. Delayed onset muscle soreness (DOMS) develops after intense exercise and is associated with an inflammatory response. The purpose of this study was to investigate the effect of glutamine supplementation on surface electromyography activity of the vastus medialis muscle (VMM) and rectus femoris muscle (RFM) and levels of creatine kinase after an eccentric contraction. SEVENTEEN HEALTHY MEN (AGE: 22.35±2.27yr; body mass: 69.91± 9.78kg; height: 177.08±4.32cm) were randomly assigned to experimental (n=9) and control groups (n=8) in a double-blind manner. In both groups, subjects were given L-glutamine supplementation (0.1g.kg(-1)) or placebo three times a week for 4 weeks. Median frequency (MDF) and mean power frequency (MPF) for VMM and RFM muscles and also CK measurements were performed before, 24h and 48 h after a resistance training session. The resistance training included 6 sets of eccentric leg extensions to exhaustion with 75% of 1RM. There was no significant difference between groups for MDF or MPF in VMM and RFM. The difference of CK level between the groups was also not significant. The results of this study indicate that glutamine supplementation has no positive effect on muscle injury markers after a resistance training session.

  19. Immediate and short-term effects of the combination of dry needling and percutaneous TENS on post-needling soreness in patients with chronic myofascial neck pain.

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    León-Hernández, Jose V; Martín-Pintado-Zugasti, Aitor; Frutos, Laura G; Alguacil-Diego, Isabel M; de la Llave-Rincón, Ana I; Fernandez-Carnero, Josue

    2016-07-11

    Dry needling (DN) and percutaneous electrical nerve stimulation (PENS) are widely used techniques in the treatment of myofascial pain. To investigate the immediate and short-term effects of the combination of DN and PENS compared to DN alone on the upper trapezius muscle. This is a 72-hour follow-up single-blinded randomized controlled trial. Sixty-two volunteer patients with chronic myofascial neck pain with active Myofascial Trigger Points (MTrPs) in the upper trapezius muscle were recruited. Randomization was performed, and 31 patients received DN treatment (DN group) and 31 received DN and PENS (DN+PENS group). The primary outcomes were neck disability index (NDI) and visual analog scale for pain for both post-needling soreness (PNS) and neck pain intensity (NPI). Pressure pain threshold (PPT) and cervical range of motion (CROM) were the secondary outcomes. We detected between-group differences in NPI and PNS in favor of the DN+PENS group immediately after treatment. No between-group differences in NDI were observed. PENS application after dry needling treatment is more effective than dry needling alone for decreasing soreness in the short term and improving neck pain intensity immediately in patients with myofascial chronic neck pain.

  20. Immediate and short-term effects of the combination of dry needling and percutaneous TENS on post-needling soreness in patients with chronic myofascial neck pain

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    Jose V. León-Hernández

    Full Text Available ABSTRACT Background Dry needling (DN and percutaneous electrical nerve stimulation (PENS are widely used techniques in the treatment of myofascial pain. Objective To investigate the immediate and short-term effects of the combination of DN and PENS compared to DN alone on the upper trapezius muscle. Method This is a 72-hour follow-up single-blinded randomized controlled trial. Sixty-two volunteer patients with chronic myofascial neck pain with active Myofascial Trigger Points (MTrPs in the upper trapezius muscle were recruited. Randomization was performed, and 31 patients received DN treatment (DN group and 31 received DN and PENS (DN+PENS group. The primary outcomes were neck disability index (NDI and visual analog scale for pain for both post-needling soreness (PNS and neck pain intensity (NPI. Pressure pain threshold (PPT and cervical range of motion (CROM were the secondary outcomes. Results We detected between-group differences in NPI and PNS in favor of the DN+PENS group immediately after treatment. No between-group differences in NDI were observed. Conclusion PENS application after dry needling treatment is more effective than dry needling alone for decreasing soreness in the short term and improving neck pain intensity immediately in patients with myofascial chronic neck pain.

  1. An ideal method for pressure sore reconstruction: a freestyle perforator-based flap.

    Science.gov (United States)

    Yang, Ching-Hsiang; Kuo, Yur-Ren; Jeng, Seng-Feng; Lin, Pao-Yuan

    2011-02-01

    Pressure sore reconstruction is quite difficult for plastic surgeons because of long-term high recurrence rates. We designed a freestyle perforator-based flap for pressure sore reconstruction considering pressure sore recurrence and further reconstruction. We used a handheld Doppler device to locate a perforator position just adjacent to the pressure ulcer. In a series of 34 patients, we used 37 perforator-based flaps to reconstruct 25 sacral, 5 ischial, and 4 trochanteric ulcers. Twenty-eight of 37 flaps healed uneventfully without complication. One patient had a flap that totally necrosed, 3 had partial flap necrosis, 3 had wound dehiscence, 1 died 3 days postoperatively, and recurrence developed in 1 patient. We used the freestyle perforator-based fasciocutaneous flap for pressure sore management with good success. These flaps are easy to design and provide good versatility for coverage. Cooperation of surgical skills and good postoperative care also contributed to the lower recurrence rates and satisfactory results.

  2. Using a modified nasotracheal tube to prevent nasal ala pressure sore during prolonged nasotracheal intubation.

    Science.gov (United States)

    Cherng, Chen-Hwan; Chen, Yuan-Wu

    2010-12-01

    Nasotracheal tube induced nasal ala pressure sores or necrosis during prolonged nasotracheal intubation have been reported, and it is a serious but preventable complication. Here we introduce a modified nasotracheal tube to prevent this complication. This modified nasotracheal tube is composed of two parts, an oral endotracheal tube and a proximal part of a preformed nasotracheal tube, which are linked by a connector. The use of this modified nasotracheal tube can prevent nasal ala pressure sores during prolonged nasotracheal intubation.

  3. Pressure Sore at an Unusual Site- the Bilateral Popliteal Fossa: A Case report

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    Kamal Kataria

    2012-05-01

    Full Text Available Pressure sore is tissue ulceration due to unrelieved pressure, altered sensory perception, and exposure to moisture. Geriatric patients with organic problems and patients with spinal cord injuries are the high-risk groups. Soft tissues over bony prominences are the common sites for ulcer development. About 95% of pressure ulcers occur in the lower part of the body. Ischial tuberosity, greater trochanter, sacrum and heel are common sites. In addition to these, pressure sores at unusual sites like nasal alae, malar eminences, cervical region and medial side of knee have also been described. Only 1.6% of the patients present with sores in areas outside the pelvis and lower extremity. In a paraplegic patient, pressure sores are usually over extensor surface of knee and heel but pressure ulcer over popliteal fossa are extremely rare. We herein report a case of a 36-years-old diabetic and paraplegic male, who presented with multiple bed sores involving the sacral area, heels and bilateral popliteal fossa. Popliteal fossa is an unusual site for pressure sores. Only one similar case has been previously reported in the literature.

  4. Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat.

    Science.gov (United States)

    Gulhas, N; Canpolat, H; Cicek, M; Yologlu, S; Togal, T; Durmus, M; Ozcan Ersoy, M

    2007-02-01

    In this study, we aimed to compare the effectiveness of dexpanthenol pastille and benzydamine hydrochloride spray on the prevention of a sore throat. One hundred and eighty patients undergoing general anaesthesia, who were ASA I-II and with their ages ranging between 15 and 70 years, were randomly allocated to three groups, each consisting of 60 patients. For group B, four puffs of benzydamine hydrochloride were sprayed into the mouth initially 30 min before the operation and repeatedly 5 min before anaesthesia induction. For group D, two pastilles of dexpanthenol were administered orally to be sucked 30 min before the operation. For group P, four puffs of distilled water were sprayed into the mouth initially 30 min before the operation. Post-operatively, patients were evaluated for a sore throat for the duration of 24 h. The incidence of a sore throat was significantly lower for group D when compared with group B and group P. The incidence of a sore throat was similar for group B and group P. According to the sore throat grading system, the number of patients experiencing no complaints was significantly higher for group D when compared with group B and group P. The number of patients achieving moderate scores was significantly higher for group B when compared with group D. The administration of 200 mg of dexpanthenol prophylactically before endotracheal intubation is effective in the prevention of post-operative sore throat.

  5. [Indication of sclerotherapy in the treatment of ischiatic pressure sore: about 13 cases].

    Science.gov (United States)

    Bahé, L; Prud'homme, A; Penaud, A; Formé, N; Zakine, G

    2012-12-01

    Ischiatic pressure sore is a common pathology of the paraplegic patient. Usually treated after medical therapy, with fasciocutaneous or musculocutaneous local flaps, despite this treatment the recurrence rate is high. Sclerotherapy, injection of pure ethanol in the cavity of the pressure sore could be an interesting solution in the armentarium of the plastic surgeon in some indications. Sclerotherapy was used for 13 patients in the plastic surgery department to treat ischiatic pressure sores with a cavity, beneath the defect. The mean length of stay was 24 days. The ischiatic pressure sore was completely healed with no skin defect or cavity for nine patients (65%). For two patients, there was a delay of healing of the skin defect but no cavity beneath. There were two early recurrences of the pressure sore. They were treated by sclerotherapy with a complete recovery in 2 months with simple hydrocolloid dressings. The mean post op follow-up was 14,6 months (4 to 24). Only one recurrence was observed after 12 months. The injection of pure ethanol in the cavity of specifics ischiatics pressure sores is a simple, fast and effective technique with a good and stable long term wound healing. The mean length of stay is shorter and the recurrence rate is equivalent to other techniques. Copyright © 2009 Elsevier Masson SAS. All rights reserved.

  6. [Giant recurrent trochanteric pressure sore: A complex medico-surgical care].

    Science.gov (United States)

    Pesenti, S; Ciceron, C; Toledano, E; Niddam, J; Tournebise, H

    2016-12-01

    Pressure sores are a frequent complication in spinal injured people. Their treatment is often long and complex. We report the case of a 60-year-old man affected with complete paraplegia who developed a right trochanteric pressure ulcer complicated with osteoarthritis of the coxofemoral joint. The treatment was done in three steps. First, a large excision of necrotic tissues and a femoral head-neck resection is performed. Then, the defect is partly covered with a Gluteus Maximus and a Biceps Femoris myocutaneous flaps. Finally, the residual defect is covered with a cutaneous pedicled groin flap called McGregor's flap. Later, the patient showed a right para-scrotal pressure sore on a heterotopic ossification of the ischial tuberosity. McGregor's flap is rarely employed for treating trochanteric pressure sores. It was here the only pedicled flap available. It was necessary to autonomize it in order to get enough length and to place a hip external fixation. The para-scrotal pressure sore illustrates the fact that bone resection surgery lifts the weight-bearing zones and can lead to pressure sores in unusual locations. The surgical treatment of these "giant" pressure sores requires a perfect collaboration between teams of rehabilitation and several surgical areas. Without a good adherence of the patient, the treatment is doomed to fail. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. [Encircling needling combined with physical factor therapy for severe pressure sore].

    Science.gov (United States)

    Jia, Chengjie; Su, Bin; Gong, Lili; Wang, Wenying; Zhang, Xiuhua

    2015-11-01

    To compare the clinical efficacy difference between encircling needling combined with physical factor therapy and simple physical factor therapy for severe pressure sore, and to explore the optimal method for severe pressure sores. Thirty-four patients with IV-grade pressure sore were randomly divided into an observation group and a control group, 17 cases in each one. Patients in the control group were treated with conventional nursing, ultrasonic wave and short-wave ultraviolet therapy; additionally, the encircling needling was applied in the observation group. All the treatment was given once a day, 5 times a week, and 4-week treatment constituted one session. Totally, two sessions of treatment were performed. Three indices, including the area of pressure sore, 24-h volume of exudates and wound-bed tissue type, were compared between the two groups before and after treatment; the clinical efficacy was evaluated in the two groups. After treatment of one session and two sessions, the area of pressure sore, 24-h volume of exudates and wound-bed tissue type were significantly reduced in the two groups (P pressure sore area and 24-h volume of exudates and improve wound-bed tissue type, which is superior to simple physical factor therapy.

  8. [Prevalence and prevention and treatment modalities for pressure sores. Study of the Emilia-Romagna region].

    Science.gov (United States)

    Melotti, Rita Maria; Fortuna, Daniela; Chiari, Paolo; Cavicchioli, Andrea; Mongardi, Maria; Santullo, Antonella; Grilli, Roberto

    2003-01-01

    This audit initiative aimed at assessing the prevalence of pressure sores in the public hospitals of Emilia-Romagna, and at monitoring the rate of use of specific modalities of prevention and cure. The design was cross-sectional, with information collected on three index days during 2000 by trained personnel. Overall, the prevalence of pressure sores at the regional level was 7.1%, with remarkable variation across hospitals (from 2.9% to 9.7%), also after adjustment for case mix. As for patterns of prevention and cure, 74% of patients at risk (according to the Braden scale) of developing a pressure sores received only standard low technology devices, and 50% of those in need were included in a systematic programme of postural change. Adequate (according to the available evidence) medications were used in 45% of patients with a pressure sore. The overall prevalence of pressure sore is close (or even inferior) to that observed in similar studies. However, variation between hospitals indicates that the current health services ability to deal with pressure sore is variable and often suboptimal. This evaluation is also supported by the limited adoption of adequate preventive and curative modalities.

  9. The evaluation of daily living activities, pressure sores and risk factors.

    Science.gov (United States)

    Aydın, Gökçen; Mucuk, Salime

    2015-01-01

    This study was conducted to assess daily living activities, pressure sores and risk factors. This was a descriptive study. The study was conducted at a rehabilitation center with 188 individuals participating in the study. Data were collected with a questionnaire form, Activities of Daily Living Scale (ADLS), Instrumental Activities of Daily Living Scale (IADLS) and Braden Risk Assessment Scale (BRAS). Among the participants, 48.9% were dependent according to activities of daily living and 71.8% were dependent on instrumental activities of daily living. It was noted that 4.8% had pressure sores and 38.8% were at high risk. A strong and positive correlation was found among ADLS, IADLS, and BRAS scores (p pressure sores (p pressure sores. Individuals who are treated at rehabilitation centers should be periodically assessed in terms of risk. Pressure sore development can be prevented with appropriate nursing interventions. To reduce the risk of developing pressure sores, nurses should describe the individual's degree of dependency according to ADLS and IADLS and initiate preventive nursing care. © 2014 Association of Rehabilitation Nurses.

  10. Gargling with ketamine attenuates the postoperative sore throat.

    Science.gov (United States)

    Rudra, A; Ray, Suchanda; Chatterjee, S; Ahmed, A; Ghosh, S

    2009-02-01

    Postoperative sore throat (POST) is a common complication of anaesthesia with endotracheal tube that affects patient satisfaction after surgery. Therefore, this complication remains to be resolved in patients undergoing endotracheal intubation. The aim of the study was to compare the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Forty patients scheduled for elective surgery under general anaesthesia were randomized into: Group C, water 30 ml; Group K, ketamine 50 mg in water 29 ml. Patients were asked to gargle this mixture for 40 seconds, 5 minutes before induction of anaesthesia. POST was graded at 4, 8 and 24 hours after operation on a four-point scale (0-3). In the Control group POST occurred more frequently, when compared with patients belonging to Ketamine group, at 4, 8, and 24 hours and significantly more patients suffered severe POST in Control group at 8 and 24 hours compared with Ketamine group (Pketamine significantly attenuated POST, with no drug-related side effects were observed.

  11. Gargling with Ketamine Attenuates the Postoperative Sore Throat

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    A Rudra

    2009-01-01

    Full Text Available Postoperative sore throat (POST is a common complication of anaesthesia with endotracheal tube that affects patient satisfaction after surgery. Therefore, this complication remains to be resolved in patients undergoing endotra-cheal intubation. The aim of the study was to compare the effectiveness of ketamine gargles with placebo in prevent-ing POST after endotracheal intubation. Forty patients scheduled for elective surgery under general anaesthesia were randomized into: Group C, water 30 ml; Group K, ketamine 50 mg in water 29 ml. Patients were asked to gargle this mixture for 40 seconds, 5 minutes before induction of anaesthesia. POST was graded at 4, 8 and 24 hours after operation on a four-point scale (0-3. In the Control group POST occurred more frequently, when compared with patients belonging to Ketamine group, at 4, 8, and 24 hours and significantly more patients suffered severe POST in Control group at 8 and 24 hours compared with Ketamine group (P< 0.05. We demonstrated that gargling with ketamine significantly attenuated POST, with no drug-related side effects were observed.

  12. The Efficacy of Ketamine Gargle in Attenuating Postoperative Sore Throat

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    Ram Prashad Sharma

    2015-06-01

    Full Text Available Introduction: Postoperative sore throat (POST is a common complication of general anesthesia with endotracheal intubation that affects the patient satisfaction after surgery. The aim of the study was to compare the effectiveness of ketamine gargle with placebo in preventing POST after endotracheal intubation. Methods: Sixty eight patients scheduled for elective surgery under general anesthesia were enrolled in this study. Patients were randomly allocated into two groups, 33 in study group and 35 in control group. Study group patients were asked to gargle with ketamine (50 mg in 1 ml mixed with 29 ml of drinking water 10 minutes before induction for 30 seconds. Controls were made to do so with 30 ml of drinking water. POST was graded at one, two, four, and 24 hrs after operation on a four-point scale (0-3. The outcome measures were compared between two groups in terms of occurrence of POST and severity of POST at one, two, four, and 24 hr to determine the efficacy of ketamine. Results: Occurrence of POST was significantly less in study group at four hours. Severity of POST was significantly low in study group at one, two and four hours as compared to that in controls. It was comparable at 24 hours. Conclusion: Ketamine gargle significantly reduced the occurrence and severity of POST.

  13. Ketamin Kumur Efektif untuk Mengurangi Sore Throat Pascaintubasi

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    M. Dwi Satriyanto

    2014-04-01

    Full Text Available Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in post operative sore throat (POST with reported incidences of 6–50%. We compared the effectiveness of ketamine gargles compared to placebo in preventing POST after endotracheal general anesthesia. One of the POST preventions by using ketamine gargle before induction, because ketamine has anti-nociceptive and anti-inflamatory properties Fifty, ASA I–II, patients undergoing elective surgery for gynecologic under general anaesthesia endotracheal were enrolled in a double blind randomized controlled trial study at Central Operating Theatre (COT Dr. Hasan Sadikin Hospital Bandung during April–June 2009. Patients were randomly allocated into two groups< of 25 subjects each: Group I, receiving ketamine 0,5 mg/kgBW in saline 30 mL; Group II, receiving saline 30 mL. Patients were asked to gargle this mixture for 30 second, 5 minutes before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0–3. POST occurred more frequently in Group II, when compared with Group I, at 0, 2, and 4 h and significantly more patients suffered POST in Group II compared with Group I (p<0.05. The conclusions of this study revealed that ketamine< gargles reduces the incidence and degree of POST.