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Sample records for oligomenorrhea

  1. The relation between athletic sports and prevalence of amenorrhea and oligomenorrhea in Iranian female athletes

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    Dadgostar Haleh

    2009-07-01

    Full Text Available Abstract Background In 1992, the concept of female athlete triad was introduced to describe the interrelated problems of amenorrhea, eating disorders and osteoporosis seen in female athletes. To gain a clearer picture of amenorrhea/oligomenorrhea in Iran, one of the main components of the female athlete triad, we therefore established this study on the prevalence of amenorrhea/oligomenorrhea in elite Iranian female athletes, also evaluating the risk factors of these disorders in the same population. Methods This study performed as a cross-sectional study. All elite Iranian female athletes of 34 sports federation, including female athletes in national teams and medalists of Tehran were invited to participate. A total of 788 (95% response rate returned the questionnaires and were examined. Younger athletes under the age of menarche were excluded. Each athlete completed a self-administered questionnaire, which covered the following questions about participant's demographic information, athletic history, history of injuries and menstrual pattern. In order to diagnose the causes of amenorrhea/Oligomenorrhea including polycystic ovary syndrome(PCOS, participants with amenorrhea/Oligomenorrhea underwent further investigation. They were evaluated by following Para clinic investigation, and an ultrasonographic study of ovary. Results The age ranged from 13–37 (mean = 21.1, SD = 4.5. Seventy one (9.0% individuals had amenorrhea/oligomenorrhea, among those, 11 (15.5% had PCOS. There was also a positive association between amenorrhea/oligomenorrhea and the following: age under 20 OR; 2.67, 95%CI(1.47 – 4.85, weight class sports OR; 2.09, 95%CI(1.15 – 3.82, endurance sports OR; 2.89, 95%CI(1.22 – 6.84, late onset of menarche OR; 3.32 95%CI(1.04–10.51, and use of oral contraceptive pills OR; 6.17, 95%CI(3.00 – 12.69. Intensity of training sport or BMI were not risk factors. Conclusion These findings support the previous findings in the literature

  2. A Clinical Study of Two Patient with Oligomenorrhea treated Carthami flos of Aqua-Acupuncture

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    Kyung-Suk Kim

    2005-12-01

    Full Text Available Object : The purpose of this study is to report the effect of oriental medicine about two patients with oligomenorrhea. Methods : Two patients had no special abnormality in BC, CBC, UA, ultra-sono, hormonal test in this study are 25-years-old and 26-years-old female who have over 40-days menstrual cycle. They had treated for 49-days, 21-days each by oriental medicine method. Their herb medicine is On-kyung-tang and Gwa-gi-eum. Main acupuncture points are Hapkok(LI4, Kihae(CV6, Gwanwon(CV3, Choksamni(ST36, Samumgyo(SP6 and moxibuation Gwanwon(CV3 and treated Carthami flos of Aqua-Acupuncture 0.05cc at Samumgyo(SP6. Results : After treatment, their menstrual cycle decreased 33-days, 36-days each. And improved dyspepsia, menstrual pain. Conclusion : Oriental medical methods are effective in two patients with oligomenorrhea had no special abnormality in BC, CBC, UA, ultra-sono, hormonal test.

  3. Age, anti-müllerian hormone, antral follicles count to predict amenorrhea or oligomenorrhea after chemotherapy with cyclophosphamide

    OpenAIRE

    2015-01-01

    Background A cohort study was performed to identify ovarian reserve markers (ORM) that predicts amenorrhea or oligomenorrhea 6 months after cyclophosphamide CTX in women with breast cancer. Methods 52 eumenorrheic patients with breast cancer were enrolled. FSH, anti-Müllerian hormone (AMH), antral follicles count (AFC) were measured before and 6 months after CTX. A logistic regression for independent samples and determination of the ROC curve were performed. Results The age of 32 years presen...

  4. Insulin, androgen, and gonadotropin concentrations, body mass index, and waist to hip ratio in the first years after menarche in girls with regular menstrual cycles, irregular menstrual cycles, or oligomenorrhea

    NARCIS (Netherlands)

    Hooff, M.H.A. van; Voorhorst, F.J.; Kaptein, M.B.H.; Hirasing, R.A.; Koppenaal, C.; Schoemaker, J.

    2000-01-01

    Data on changes in hormone concentrations during the first years after menarche are scarce. We studied the relation between gynecological age (age minus age at menarche), hormone concentrations, and body measurements from the 1st to the 6th yr after menarche in 229 observations of girls with regular

  5. Polycystic ovary syndrome: from phenotype to genetype

    NARCIS (Netherlands)

    Y.V. Louwers (Yvonne)

    2014-01-01

    markdownabstract__Abstract__ oligomenorrhea or amenorrhea, hirsutism or hyperandrogenism and polycystic ovarian morphology. Later in life, adverse metabolic implications, such as obesity, insulin resistance, type 2 diabetes and cardiovascular disease, become more prominent. In this thesis, we aimed

  6. How I Manage Exercise-Related Menstrual Disturbances.

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    Shangold, Mona M.

    1986-01-01

    Amenorrhea and oligomenorrhea are often related to heavy exercise, but these conditions can signal a serious pathologic condition. Tests to pinpoint causes of menstrual dysfunctions are listed, and treatments to establish a proper hormone balance are described. (MT)

  7. Polycystic ovary syndrome: from phenotype to genetype

    NARCIS (Netherlands)

    Y.V. Louwers (Yvonne)

    2014-01-01

    markdownabstract__Abstract__ oligomenorrhea or amenorrhea, hirsutism or hyperandrogenism and polycystic ovarian morphology. Later in life, adverse metabolic implications, such as obesity, insulin resistance, type 2 diabetes and cardiovascular disease, become more prominent. In this thesis, we

  8. Clinical characteristics in Taiwanese women with polycystic ovary syndrome.

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    Hsu, Ming-I

    2015-09-01

    Polycystic ovary syndrome (PCOS) is one of the most common hormonal endocrine disorders in women of reproductive age. It consists of a heterogeneous collection of signs and symptoms that together form a disorder spectrum. The diagnosis of PCOS is principally based on clinical and physical findings. The extent of metabolic abnormalities in women with PCOS varies with phenotype, body weight, age, and ethnicity. For general population, the prevalence of hyperandrogenism and oligomenorrhea decreases with age, while complications such as insulin resistance and other metabolic disturbances increase with age. Obese women with PCOS have a higher risk of developing oligomenorrhea, amenorrhea, hyperandrogenemia, insulin resistance, and lower luteinizing hormone (LH) to follicle stimulation hormone (FSH) ratios than non-obese women with PCOS. The LH to FSH ratio is a valuable diagnostic tool in evaluating Taiwanese women with PCOS, especially in the diagnosis of oligomenorrhea. Overweight/obesity is the major determinant of cardiovascular and metabolic disturbances in women of reproductive age.

  9. Prediction of ovulation induction outcome in normogonadotropic anovulatory infertility

    NARCIS (Netherlands)

    B. Imani (Babak)

    2002-01-01

    textabstractAnovulation is a major cause of female reproductive dysfunction and can be identified in approximately 18-25% of couples presenting with infertility (Hull et al., 1985). Oligomenorrhea (arbitrarily defined as menstrual periods occurring at intervals betvveen 35 days to 6 months) or ameno

  10. Complementary Therapy in Polycystic Ovary Syndrome

    OpenAIRE

    Aquino, Carmen Imma; Nori, Stefania Lucia

    2014-01-01

    Polycystic Ovary Syndrome (PCOS) is an endocrine disease. PCOS afflicts 5 to 10 % of women of reproductive age. The symptoms are: amenorrhea, oligomenorrhea, hirsutism, obesity, infertility, chronic hyperandrogenic anovulation and acne. Other risk factors aggravate this condition: insulin resistance, obesity, hypertension, dyslipidemia, inflammation and subclinical cardiovascular disease. Anxiety, depression and reduced quality of life are also common. This review highlights the mech...

  11. Cetrorelix suppression test in the diagnostic work-up of severe hyperandrogenism in adolescence.

    NARCIS (Netherlands)

    Man, M de; Derksen, E.; Pieters, G.; Boer, H. de

    2008-01-01

    Conventional diagnostic procedures failed to provide a definitive diagnosis in a 15 year-old girl presenting with severe hirsutism, oligomenorrhea, and markedly elevated serum testosterone levels. To examine whether androgen overproduction was luteinizing hormone (LH) dependent and thus likely of ov

  12. Effect of hyperprolactinemia during development in children and adolescents.

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    Correll, Christoph U

    2008-08-01

    Increased levels of prolactin associated with some antipsychotic treatment can potentially lead to serious adverse events including gynecomastia, galactorrhea, oligomenorrhea, amenorrhea, and pituitary tumors. Clinicians may need to employ pharmacotherapeutic interventions such as reducing dosage, switching antipsychotics, or prescribing adjunctive agents to minimize or prevent these negative side effects and improve patients' outcomes.

  13. Complementary Therapy in Polycystic Ovary Syndrome

    OpenAIRE

    Aquino, Carmen Imma; Nori, Stefania Lucia

    2014-01-01

    Polycystic Ovary Syndrome (PCOS) is an endocrine disease. PCOS afflicts 5 to 10 % of women of reproductive age. The symptoms are: amenorrhea, oligomenorrhea, hirsutism, obesity, infertility, chronic hyperandrogenic anovulation and acne. Other risk factors aggravate this condition: insulin resistance, obesity, hypertension, dyslipidemia, inflammation and subclinical cardiovascular disease. Anxiety, depression and reduced quality of life are also common. This review highlights the mechanisms an...

  14. Polycystic ovary syndrome and hirsutism

    OpenAIRE

    Evliyaoğlu, Olcay

    2011-01-01

    Polycystic ovary syndrome is a multi factorial heterogenous disorder characterized by chronic anovulation and hyperandrogenism Diagnosis is based on clinical or laboratory evidence of nbsp; hyperandrogenism nbsp; For diagnosis at least two of the three Rotterdam criteria oligo anovulation clinical or biochemical signs of hyperandrogenism polycystic ovaries nbsp; should be ensured Clinical symptoms usually begin around menarche nbsp; Oligomenorrhea amenorrhea hirsutism acne alopecia can be ass...

  15. Polycystic ovary syndrome in Salvador, Brazil: a prevalence study in primary healthcare

    OpenAIRE

    Gabrielli Ligia; Aquino Estela ML

    2012-01-01

    Abstract Background Polycystic ovary syndrome (PCOS) is a common condition in women of reproductive age. It is characterized by hyperandrogenism, oligomenorrhea/amenorrhea and polycystic ovaries. It is associated with obesity, diabetes, dyslipidemia and cardiovascular disease. No studies have been conducted on the prevalence of PCOS in Brazilian or South American women. Few studies using the Rotterdam criteria have been published. The objective of the present study was to calculate the preval...

  16. A case of Cushing s syndrome in pregnancy secondary to an adrenal cortical adenoma.

    OpenAIRE

    Kim, Hwi Gon; Lee, Kwang Hyun; Je, Goo Hwa; Han, Myoung Seok

    2003-01-01

    Cushing s syndrome in pregnant women is rare and difficult to be diagnosed because of the syndrome's association with oligomenorrhea or amenorrhea and the changes in cortisol metabolism during normal pregnancy. Cushing syndrome in pregnancy is usually confused with complicated pregnancy, such as preeclampsia or gestational diabetes, and its rarity leads to a low degree of clinical suspicion, often delaying diagnosis. We experienced a case of Cushing s syndrome in pregnancy, which had been con...

  17. Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin)

    OpenAIRE

    Kelly, Deanna L; Wehring, Heidi J.; Earl, Amber K; Sullivan, Kelli M; Dickerson, Faith B.; Feldman, Stephanie; McMahon, Robert P.; Buchanan, Robert W.; Warfel, Dale; Keller, William R.; Fischer, Bernard A.; Shim, Joo-Cheol

    2013-01-01

    Prolactin elevations occur in people treated with antipsychotic medications and are often much higher in women than in men. Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gynecomastia in females and is also associated with sexual dysfunction and bone loss. These side effects increase risk of antipsychotic nonadherence and suicide and pose significant problems in the long term management of women with schizophrenia. In this manuscript, we review the literatur...

  18. Symptoms of hyperprolactinemia with normal serum prolactin: is treatment required?

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    Deepti Verma

    2016-06-01

    Full Text Available Galactorrhea with menstrual abnormalities like oligomenorrhea or amenorrhea point towards a provisional diagnosis of increased serum prolactin levels or hyperprolactinemia. However, as the prolactin hormone is heterogeneous with two forms- the bioactive and the immunoactive forms, patients can have all the features of hyperprolactinemia with normal serum prolactin levels. [Int J Reprod Contracept Obstet Gynecol 2016; 5(6.000: 2041-2042

  19. Energy Availability and Reproductive Function in Female Endurance Athletes

    DEFF Research Database (Denmark)

    Melin, Anna Katarina

    The overall aim of this PhD project was to study the prevalence and potential dietary risk factors and consequences of current low EA and oligomenorrhea/functionel hypothalamic amenorrhea (FHA) in a group of female elite endurance athletes. The results indicated that athletes with current low and......-reported screening tool to complement existing validated disordered eating screening instruments for the identification of female athletes at risk for the Triad....

  20. Mentha longifolia syrup in secondary amenorrhea: a double-blind, placebo-controlled, randomized trials

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    Mokaberinejad Roshanak

    2012-12-01

    Full Text Available Abstract Background Amenorrhea is defined as the cessation of menses. Hormone therapy is the most common treatment. Due to the contraindications and side effects of it and the increasing demand for alternative medicine substitutes, Mentha longifolia L. was used in this study. Mentha longifolia L. is a known medication in Iranian traditional medicine to induce menstrual bleeding in women with secondary amenorrhea and oligomenorrhea. Methods A double-blind, randomized, placebo-controlled, multicenter study was conducted in 120 women with secondary amenorrhea and oligomenorrhea. Treatment consisted of sequential oral syrup, 45 ml (15 ml three times a day for 2 weeks. If the patients did not have menstruation after 2 weeks of taking the medication, we would wait for two more weeks. If the patients had menstruation at each stage of using the drug, we started it one week after the end of menstruation. But if the patients had not menstruate after four weeks (two-week using of drug and waiting for two more weeks, the previous steps were repeated. The drug and placebo were repeated in three cycles of menstruation. Bleeding was documented by the patient on diary cards. The primary outcome variable was the occurrence (yes/no of bleeding during the first treatment cycle. The secondary efficacy outcome was the regularity of bleeding pattern during the three cycles of the study. Results The number of women with bleeding during the first cycle were higher in the drug group as in the placebo group (68.3% vs. 13.6%; p Mentha longifolia L. syrup. Conclusion In conclusion, Mentha longifolia L. syrup is a safe, well-tolerated, and effective choice in inducing bleeding and maintaining regular bleeding in women with secondary amenorrhea and oligomenorrhea.

  1. Prevalence of polycystic ovarian syndrome in Indian adolescents.

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    Nidhi, Ram; Padmalatha, Venkatram; Nagarathna, Raghuram; Amritanshu, Ram

    2011-08-01

    PCOS is a common female endocrine disorder with prevalence ranging from 2.2% to 26%. Most reports have studied adult women with age ranged from 18 to 45 years. The aim of this study was to find the prevalence of PCOS in Indian adolescents. We prospectively studied 460 girls aged 15 to 18 years from a residential college in Andhra Pradesh, South India, who underwent clinical examination. Out of which 72 girls with oligomenorrhea and/or hirsutism were invited for biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam criteria. PCOS was defined as the presence of any two of the three features: (1) Oligo/amenorrhea: absence of menstruation for 45 days or more and/or ≤8 menses per year. (2) Clinical hyperandrogenism: Modified Ferriman and Gallway (mFG) score of 6 or higher. (3) Polycystic ovaries: presence of >10 cysts, 2-8 mm in diameter, usually combined with increased ovarian volume of >10 cm(3), and an echo-dense stroma in pelvic ultrasound scan. Out of 460 girls, one (0.22%) had oligo/amenorrhea with clinical hyperandrogenism, 29 (6.30%) had oligomenorrhea with polycystic ovaries, one (0.22%) had polycystic ovaries with clinical hyperandrogenism and 11 (2.39%) had oligomenorrhea with polycystic ovaries in the presence of clinical hyperandrogenism. Thus 42 (9.13%) girls satisfied Rotterdam's criteria for PCOS, which increased to 50.46 (10.97%) when imputed data were included. Prevalence of PCOS in Indian adolescents is 9.13%.This draws attention to the issue of early diagnosis in adolescent girls. 2011 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  2. Investigating Risk Factors for Cardiovascular Disease Based on Polycystic Ovary Syndrome phenotypes in the 18-14 year Old High School Girls in Shiraz 2009

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    MH Dabbaghmaneh

    2012-05-01

    Full Text Available Introduction: In patients with polycystic ovary syndrome hyperinsulinaemia, insulin resistance, dyslipidemia and hyperglycemia may represent an increased risk for coronary cardiovascular disease .This study aimed to investigate risk factors for cardiovascular disease based on polycystic ovary syndrome phenotypes in Shiraz. Methods: This Cross-sectional study was performed on 3200 students aged 18-14. Demographic survey, clinical signs of androgen excess (acne, hirsutism, alopecia, Ultrasound were applied in order to find the cyst. Tests included prolactin, dehydroepiandrodion sulfate, and oral glucose tolerance test, fasting blood glucose, blood sugar two hours later, triglycerides, cholesterol, high density lipoprotein. Data were submitted to SPSS software, version 11.5 and then analyzed by chi-square tests. Results: The serum cholesterol mean in four phenotypes had a statistically significant relationship with non-PCOS patients(p<0.05. Mean of serum cholesterol in oligomenorrhea, Hyperandrogenism and polycystic ovary phenotype (195.09±30.28 was higher than the other phenotypes. Mean of serum cholesterol and low density lipoprotein(LDL-C were significantly higher in patients with Hyperandrogenism and polycystic ovarian phenotype(130.046±26.27 and oligomenorrhea, Hyperandrogenism and polycystic ovary syndrome phenotype(138.58±28.34 compared with non-infected individuals. Serum glucose mean in all phenotype was higher than non-infected after two hours and it showed a significant relation in oligomenorrhea and also polycystic ovarian phenotype(98.03 ± 20.98 versus 87.5±12.97 with non-infected individuals. Conclusion: Biochemical factors that lead to increased risk of cardiovascular diseases is increased in patients with polycystic ovary syndrome. Therefore, it should be attended in prevention programs

  3. Polycystic ovary syndrome: reviewing diagnosis and management of metabolic disturbances.

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    Spritzer, Poli Mara

    2014-03-01

    Polycystic ovary syndrome (PCOS) is a common condition in women at reproductive age associated with reproductive and metabolic dysfunction. Proposed diagnosed criteria for PCOS include two out of three features: androgen excess, menstrual irregularity, and polycystic ovary appearance on ultrasound (PCO), after other causes of hyperandrogenism and dysovulation are excluded. Based on these diagnostic criteria, the most common phenotypes are the "classic PCOS"--hyperandrogenism and oligomenorrhea, with or without PCO; the "ovulatory phenotype"--hyperandrogenism and PCO in ovulatory women; and the "non-hyperandrogenic phenotype", in which there is oligomenorrhea and PCO, without overt hyperandrogenism. The presence of obesity may exacerbate the metabolic and reproductive disorders associated with the syndrome. In addition, PCOS women present higher risk for type 2 diabetes and higher prevalence of cardiovascular risk factors that seems to be associated with the classic phenotype. The main interventions to minimize cardiovascular and metabolic risks in PCOS are lifestyle changes, pharmacological therapy, and bariatric surgery. Treatment with metformin has been shown to improve insulin sensitivity, lowering blood glucose and androgen levels. These effects are more potent when combined with lifestyle interventions. In conclusion, besides reproductive abnormalities, PCOS has been associated to metabolic comorbidities, most of them linked to obesity. Confounders, such as the lack of standard diagnostic criteria, heterogeneity of the clinical presentation, and presence of obesity, make management of PCOS difficult. Therefore, the approach to metabolic abnormalities should be tailored to the risks and treatment goals of each individual woman.

  4. Mentha Longifolia Syrup in Secondary Amenorrhea: a Double-blind, Placebo-Controlled, Randomized Trials

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    Roshanak Mokaberinejad

    2012-12-01

    Full Text Available Amenorrhea is defined as the cessation of menses. Hormone therapy is the most common treatment. Due to the contraindications and side effects of it and the increasing demand for alternative medicine substitutes, Mentha longifolia L. was used in this study. Mentha longifolia L. is a known medication in Iranian traditional medicine to induce menstrual bleeding in women with secondary amenorrhea and oligomenorrhea.Methods A double-blind, randomized, placebo-controlled, multicenter study was conducted in 120 women with secondary amenorrhea and oligomenorrhea. Treatment consisted of sequential oral syrup, 45 ml (15 ml three times a day for 2 weeks. If the patients did not have menstruation after 2 weeks of taking the medication, we would wait for two more weeks. If the patients had menstruation at each stage of using the drug, we started it one week after the end of menstruation. But if the patients had not menstruate after four weeks (two-week using of drug and waiting for two more weeks, the previous steps were repeated. The drug and placebo were repeated in three cycles of menstruation. Bleeding was documented by the patient on diary cards. The primary outcome variable was the occurrence (yes/no of bleeding during the first treatment cycle. The secondary efficacy outcome was the regularity of bleeding pattern during the three cycles of the study.Results The number of women with bleeding during the first cycle were higher in the drug group as in the placebo group (68.3% vs. 13.6%; p < 0.001. The regularity of bleeding throughout the study was markedly better in the drug group compared with those given placebo (33.3% vs. 3.3%; p < 0.001. No notable complication or side effect was reported in relation to Mentha longifolia L. syrup.ConclusionIn conclusion, Mentha longifolia L. syrup is a safe, well-tolerated, and effective choice in inducing bleeding and maintaining regular bleeding in women with secondary amenorrhea and oligomenorrhea.

  5. Mentha longifolia syrup in secondary amenorrhea: a double-blind, placebo-controlled, randomized trials

    Science.gov (United States)

    2012-01-01

    Background Amenorrhea is defined as the cessation of menses. Hormone therapy is the most common treatment. Due to the contraindications and side effects of it and the increasing demand for alternative medicine substitutes, Mentha longifolia L. was used in this study. Mentha longifolia L. is a known medication in Iranian traditional medicine to induce menstrual bleeding in women with secondary amenorrhea and oligomenorrhea. Methods A double-blind, randomized, placebo-controlled, multicenter study was conducted in 120 women with secondary amenorrhea and oligomenorrhea. Treatment consisted of sequential oral syrup, 45 ml (15 ml three times a day) for 2 weeks. If the patients did not have menstruation after 2 weeks of taking the medication, we would wait for two more weeks. If the patients had menstruation at each stage of using the drug, we started it one week after the end of menstruation. But if the patients had not menstruate after four weeks (two-week using of drug and waiting for two more weeks), the previous steps were repeated. The drug and placebo were repeated in three cycles of menstruation. Bleeding was documented by the patient on diary cards. The primary outcome variable was the occurrence (yes/no) of bleeding during the first treatment cycle. The secondary efficacy outcome was the regularity of bleeding pattern during the three cycles of the study. Results The number of women with bleeding during the first cycle were higher in the drug group as in the placebo group (68.3% vs. 13.6%; p < 0.001). The regularity of bleeding throughout the study was markedly better in the drug group compared with those given placebo (33.3% vs. 3.3%; p < 0.001). No notable complication or side effect was reported in relation to Mentha longifolia L. syrup. Conclusion In conclusion, Mentha longifolia L. syrup is a safe, well-tolerated, and effective choice in inducing bleeding and maintaining regular bleeding in women with secondary amenorrhea and oligomenorrhea. PMID

  6. Hubungan Resistensi Insulin dengan Gambaran Klinis Sindrom Ovarium Polikistik

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    Meliza Wahyuni

    2015-09-01

    Full Text Available Abstrak Sindrom Ovarium Polikistik (SOPK merupakan kelainan endokrin dan metabolik pada wanita usia reproduksi. SOPK merupakan kumpulan gejala dari amenore, oligomenore, infertilitas, obesitas, hirsutisme, acne, alopesia, dan akantosis nigrikan. Resistensi insulin diyakini sebagai salah satu penyebab tersering dari SOPK melalui berbagai mekanisme. Tujuan penelitian ini adalah untuk mengetahui hubungan resistensi insulindengan gambaran klinis SOPK. Penelitian ini dilakukan pada pasien SOPK dengan menggunakan studi cross sectional dengan pendekatan retrospektif, yaitu mengumpulkan kejadian masa lalu dari tahun 2009 - 2011, jumlah sampel 105 orang. Analisis statistik yang digunakan adalah uji chi-square. Hasil penelitian didapatkan 33,3% penderita SOPK mengalami resistensi insulin. Berdasarkan gambaran klinis 35,23% amenore, 64,77% oligomenore, 72,04% infertilitas, 50,5% obesitas, 0,95% hirsutisme, acne 20%, alopesia dan akantosis nigrikan0%. Dari 33,3% SOPK dengan resistensi insulin 40% amenore, 60% oligomenore, 71,9% infertilitas, 77,14% obesitas, dan 0% hirsutisme. Berdasarkan hasil uji statistik ditemukan hubungan bermakna antara resistensi insulin dengan obesitas (p<0,05 dan tidak ditemukan hubungan bermakna antara resistensi insulin dengan infertilitas, hirsutisme, dan acne (p>0,05.Kata Kunci: SOPK, resistensi insulin, gambaran klinisAbstract Polycystic Ovary Syndrome (PCOS is an endocrine and metabolic disorders that is common in reproductive-aged women. PCOS is a group of symptoms, such as amenorrhea, oligomenorrhea, infertility, obesity, hirsutism, acne, alopecia, and achanthosis nigricans. Insulin resistance is believed to be one of the most common causes of PCOS through a various mechanisms. The objective of this study was to find out the relationship between insulin resistance and clinical manifestation of PCOS. This research was done in patients with PCOS using cross sectional study with retrospective approach. Data was collected from

  7. PALM-COEIN Nomenclature for Abnormal Uterine Bleeding.

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    Deneris, Angela

    2016-05-01

    Approximately 30% of women will experience abnormal uterine bleeding (AUB) during their life time. Previous terms defining AUB have been confusing and imprecisely applied. As a consequence, both clinical management and research on this common problem have been negatively impacted. In 2011, the International Federation of Gynecology and Obstetrics (FIGO) Menstrual Disorders Group (FMDG) published PALM-COEIN, a new classification system for abnormal bleeding in the reproductive years. Terms such as menorrhagia, menometrorrhagia, metrorrhagia, dysfunctional uterine bleeding, polymenorrhea, oligomenorrhea, and uterine hemorrhage are no longer recommended. The PALM-COEIN system was developed to standardize nomenclature to describe the etiology and severity of AUB. A brief description of the PALM-COEIN nomenclature is presented as well as treatment options for each etiology. Clinicians will frequently encounter women with AUB and should report findings utilizing the PALM-COEIN system.

  8. Stress and Eating Disorder Behavior in Anorexia Nervosa as a Function of Menstrual Cycle Status

    Science.gov (United States)

    Jappe, Leah M.; Cao, Li; Crosby, Ross D.; Crow, Scott J.; Peterson, Carol B.; Le Grange, Daniel; Engel, Scott G.; Wonderlich, Stephen A.

    2013-01-01

    Objective Fluctuations in ovarian hormones during the menstrual cycle and psychosocial stress contribute to eating disorder (ED) behavior. Methods Using ecological momentary assessment techniques, this study examined relationships between stress and binge eating, self-induced vomiting, and dietary restriction based on menstrual cycle status in anorexia nervosa (AN). 109 females with full and subthreshold AN (17–45 years old) recorded ED behavior and stress ratings over two weeks. Using hierarchical linear modeling, individuals with eumenorrhea and those with amenorrhea or oligomenorrhea were compared. Results Following episodes of meal skipping, momentary stress decreased in individuals with normal menstrual cycles and increased in those with irregular menstrual cycles. Discussion Results suggest that changes in stress severity in response to food restriction may differ based on ovarian hormonal status and may be a mechanism by which AN is maintained in individuals without menstrual disturbance. PMID:24222529

  9. Antipsychotic-induced Hyperprolactinemia

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    Suheyla Dogan Bulut

    2015-06-01

    Full Text Available Prolactin provides the growth of the mammary gland during pregnancy and synthesis and preparation of breast milk for lactation. Antipsychotics and antidepressants that are frequently used in psychiatry, cause hyperprolactinemia. The prevalent opinion is that especially typical antipsychotics increase prolactin levels primarily by blocking D2 receptors in the anterior pituitary. The effects of atypical antipsychotics on hyperprolactinemia vary. Hyperprolactinemia causes galactorrhea, gynecomastia, sexual dysfunction, infertility, acne, hirsutism in women, weight gain, obesity and mood changes in addition to menstrual irregularities such as oligomenorrhea, polymenorrhea and amenorrhea. In the long term, hyperprolactinemia may cause reduction in bone density and osteoporosis. Hyperprolactinemia as a side effect of antipsychotics drugs and its treatment will be reviewed in this article. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2015; 7(2: 109-124

  10. Müllerian duct anomalies diagnosed by saline contrast sonohysterography

    DEFF Research Database (Denmark)

    Dreisler, Eva; Stampe Sørensen, Søren

    2014-01-01

    OBJECTIVE: To estimate the prevalence of uterine müllerian duct anomalies in a general population. DESIGN: Cross-sectional study. SETTING: University hospital in collaboration with the Danish Civil Registry. PATIENT(S): A total of 1,654 women randomly recruited from a general population; 686 women...... were eligible and accepted inclusion (429 pre- and 257 postmenopausal). Saline contrast sonohysterography (SCSH) was finally performed in 622 women (aged 20-74 years) (the procedure was impossible owing to cervical stenosis in 58, contraindicated in 2, other patient-related factors in 4). INTERVENTION(S.......7%), 1 complete septate (1.6%), and 1 unicorn uterus (1.6%). Müllerian anomalies were significantly more frequently diagnosed in nulliparous (20% [26 of 128]) compared with parous women (7% [35 of 494]). Müllerian anomalies were more frequent in women with oligomenorrhea compared with women with normal...

  11. Endometrioid Endometrial Carcinoma Indirectly Caused by Pituitary Prolactinoma:A Case Report

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    Kimihiro Nishino

    2013-01-01

    Full Text Available We present the case of a 44-year-old nulliparous woman who experienced irregular menstrual cycles for about 10 years and developed both pituitary prolactinoma and endometrioid endometrial carcinoma. In premenopausal women, hyperprolactinemia causes hypogonadism by inhibiting secretion of gonadotropin-releasing hormone and thus suppressing luteinizing hormone levels, which can cause menstrual disorders ranging from amenorrhea, oligomenorrhea and chronic anovulatory cycle to short luteal phase of the menstrual cycle. A chronic anovulatory menstrual cycle is the most common cause of long-term exposure of the endometrium to endogenous estrogen without adequate opposition from progestins, which can lead to endometrioid endometrial carcinoma. In this case, pituitary prolactinoma may have caused the chronic anovulatory cycle and indirectly led to the endometrioid endometrial carcinoma. In patients for whom the cause of irregular menstruation and chronic anovulatory cycle is suspected to be hyperprolactinemia, explorations of both the hypophysis and endometrium are essential.

  12. Endometrioid endometrial carcinoma indirectly caused by pituitary prolactinoma: a case report.

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    Nishino, Kimihiro; Niwa, Yuri; Mizutani, Teruyuki; Shimizu, Ken; Hayashi, Kazumasa; Chaya, Jyunya; Kato, Noriko; Yamamuro, Osamu

    2013-01-01

    We present the case of a 44-year-old nulliparous woman who experienced irregular menstrual cycles for about 10 years and developed both pituitary prolactinoma and endometrioid endometrial carcinoma. In premenopausal women, hyperprolactinemia causes hypogonadism by inhibiting secretion of gonadotropin-releasing hormone and thus suppressing luteinizing hormone levels, which can cause menstrual disorders ranging from amenorrhea, oligomenorrhea and chronic anovulatory cycle to short luteal phase of the menstrual cycle. A chronic anovulatory menstrual cycle is the most common cause of long-term exposure of the endometrium to endogenous estrogen without adequate opposition from progestins, which can lead to endometrioid endometrial carcinoma. In this case, pituitary prolactinoma may have caused the chronic anovulatory cycle and indirectly led to the endometrioid endometrial carcinoma. In patients for whom the cause of irregular menstruation and chronic anovulatory cycle is suspected to be hyperprolactinemia, explorations of both the hypophysis and endometrium are essential.

  13. Fine-needle aspiration cytology of ovarian steroid cell tumor: A rare case report

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    Nidhi Agrawal

    2015-01-01

    Full Text Available Steroid cell tumors (SCTs of the ovary are a rare subgroup of sex cord tumors that account for less than 0.1% of all ovarian tumors. These tumors can produce steroids, especially testosterone, which produces symptoms such as hirsutism, amenorrhea/oligomenorrhea, and male patterned voice. For evaluation of the androgen excess, testosterone and dehydroepiandrosterone sulfate (DHEA-S are the first laboratory tests to be measured. Abdominal ultrasound and magnetic resonance imaging (MRI are useful radiologic imaging techniques. Although SCTs are generally benign, the risk of malignant transformation is always present. Surgical excision of tumor is the most important and hallmark treatment. The present case signifies the early preoperative diagnosis of a virilizing SCT, based on cytological features and its careful correlation with clinicopathological and radiological findings.

  14. Steroid Cell Tumor of the Ovary in an Adolescent: A Rare Case Report

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    Gokhan Boyraz

    2013-01-01

    Full Text Available Steroid cell tumors (SCTs of the ovary are a rare subgroup of sex cord tumors, account for less than 0.1% of all ovarian tumors, and also will present at any age. These tumors can produce steroids, especially testosterone, and may give symptoms like hirsutism, hair loss, amenorrhea, or oligomenorrhea. For the evaluation of androgen excess, testosterone and dehydroepiandrosterone sulfate (DHEA-S are the first laboratory tests to be measured. A pelvic ultrasound and a magnetic resonance imaging are useful radiologic imaging techniques. Although steroid cell tumors are generally benign, there is a risk of malignant transformation and clinical malignant formation. Surgery is the most important and hallmark treatment.

  15. Female athletes and health

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    Malara Marzena

    2016-06-01

    Full Text Available It is well documented that regular physical activity has a beneficial effect on human health by affecting the metabolic processes that are of fundamental importance in the body’s functions, such as insulin sensitivity and glucose disposal, as well as lipid and lipoprotein turnover. On the other hand, there is a wealth of studies which indicate that strenuous, regular physical activity, such as that performed by high performance athletes, may be detrimental for the athletes’ health especially in women. This review focuses on the factors that contribute to health problems in female athletes, named the female athlete triad, which includes excessive dieting, menstrual dysfunctions (anovulatory menstrual cycles, oligomenorrhea, amenorrhea and a low bone mineral density (BMD. As a result of these factors, women who participate in sports, especially those focused on leanness, need special attention and education from health professionals, coaches and the athletes themselves to prevent the detrimental effects of an inadequate energy supply against high energy demands.

  16. Dermatologic manifestation of hyperandrogenism: a retrospective chart review.

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    Clark, Charlotte M; Rudolph, Jennifer; Gerber, Donald A; Glick, Sharon; Shalita, Alan R; Lowenstein, Eve J

    2014-01-01

    Several studies have described a wide spectrum of hyperandrogenism diseases, many of which are difficult to distinguish from each other. In order to better understand diseases of hyperandrogenism, the authors performed a retrospective study of the cutaneous features and metabolic findings in women with hyperandrogenism. A retrospective chart analysis compiled by three dermatologists in both academic and private settings was performed, including patients presenting with > or = 2 manifestations of hyperandrogenism. Relevant dermatologic and associated manifestations and laboratory and imaging study findings were reviewed. Moderate to severe acne was the most common manifestation. Other common manifestations that patients first presented with include hirsutism, acanthosis nigricans, androgenic alopecia, and skin tags. Oligomenorrhea was the most common systemic presenting sign. Statistical analysis of various clinical markers revealed correlations with hyperandrogenemia. Acanthosis nigricans and hirsutism were found to be useful clinical markers for hyperandrogenism, whereas androgenic alopecia was not. This study provides some insights into the presentation and diverse manifestations seen in hyperandrogenism.

  17. The reproductive system function at women athletes are training by lifting and taekwondo

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    Nekhanevich O.B.

    2010-01-01

    Full Text Available The purpose of investigation is studying the character and leading mechanisms of reproductive system pathology at women athletes are training by lifting and taekwondo. The object of research was the medical control at women are training in lifting and taekwondo. The results of the research have shown that the physical and psychoemotional overexertion with restriction of eating lead to adrenocorticotropic horomon considerable quantity emission which stimulates suprarenal glands and cause the development of hyperanrogenemy and ovaries functions depression. The athletes have more frequent menstrual cycle disturbances such as opsomenorrhea, oligomenorrhea and algodysmenorrhea. Typically there are changes of indices of physical development, appearance the symptoms of psychological masculinithation, hirsutism and secondary ovaries disturbance.

  18. [Vitex Agnus Castus in the treatment of hyperprolactinemia and menstrual disorders - a case report].

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    Męczekalski, Błażej; Czyżyk, Adam

    2015-07-01

    We describe a patient with mild hyperprolactinemia and menstrual disorders (oligomenorrhea). She presented relative hypoestrogenism in laboratory tests. Magnetic resonans excluded the presence of pituitary adenoma. Because patient developed a bromocriptine intolerance, the Vitex Agnus Castus (VAC) extract has been introduced. The VAC therapy was effective, with symptoms relief and improvement of hormonal tests. The VAC medicines are indicated for the treatment of premenstrual syndrome (PMS), mastalgia, menstrual disorders and mild hyperprolactinemia. The mechanism of action is not fully understood, but it is related to dopaniergic activity of diterpenes and castacin in VAC. The randomized clinical trials revealed efficacy of VAC extract in the treatmet of hyperprolactinemia, menstrual disorders, PMS and mastalgia. Good tolerability, lack of serious side-effects and drug interactions are the advantages of the VAC preparations.

  19. Immunoreactive prolactin in breast milk and plasma of women with hyperprolactinemia, galactorrhea and menstrual dysfunction.

    Science.gov (United States)

    Yuen, B H

    1986-01-01

    Prolactin levels were measured by radioimmunoassay in paired breast milk and plasma samples of 11 hyperprolactinemic women with galactorrhea and various menstrual disorders (amenorrhea, n = 8; oligomenorrhea, n = 2; luteal phase defect, n = 1) before and during treatment with bromocriptine (Parlodel, Sandoz). Pretreatment levels of prolactin in the milk and plasma were 80 +/- 13 ng/mL (mean +/- SEM) and 47 +/- 7 ng/mL (P less than 0.05), respectively. While on treatment, the concentration gradient for prolactin remained in favour of the milk, with values for milk and plasma 59 +/- 11 and 29 +/- 3 ng/mL (P less than 0.01), respectively. Thus, bromocriptine lowered the prolactin concentrations in both breast milk and plasma. Since prolactin in milk is biologically active, these findings may be relevant to the initiation and maintenance of lactation in women with abnormal lactogenesis.

  20. Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin).

    Science.gov (United States)

    Kelly, Deanna L; Wehring, Heidi J; Earl, Amber K; Sullivan, Kelli M; Dickerson, Faith B; Feldman, Stephanie; McMahon, Robert P; Buchanan, Robert W; Warfel, Dale; Keller, William R; Fischer, Bernard A; Shim, Joo-Cheol

    2013-08-22

    Prolactin elevations occur in people treated with antipsychotic medications and are often much higher in women than in men. Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gynecomastia in females and is also associated with sexual dysfunction and bone loss. These side effects increase risk of antipsychotic nonadherence and suicide and pose significant problems in the long term management of women with schizophrenia. In this manuscript, we review the literature on prolactin; its physiology, plasma levels, side effects and strategies for treatment. We also present the rationale and protocol for an ongoing clinical trial to treat symptomatic hyperprolactinemia in premenopausal women with schizophrenia. More attention and focus are needed to address these significant side effects and help the field better personalize the treatment of women with schizophrenia.

  1. [Ischemic stroke in a young woman of Turner syndrome with T1-weighted imaging-pulvinar sign].

    Science.gov (United States)

    Sangkyun, Ko; Kawano, Akiko; Yamanoi, Takahiko; Tokunaga, Keiko

    2014-01-01

    A 39-year-old woman developed right hemiparesis in a few days. Magnetic resonance images revealed cerebral infarction in the territory of the left lenticulostriate artery, and MR angiography showed severe stenosis of the middle and anterior cerebral arteries and moderate one of the vertebral arteries. Bilateral and symmetric T1 hyperintensity in the pulvinar (T1-weighted imaging-pulvinar sign; "T1 pulvinar sign") was detected, which is recognized as a key imaging of Fabry disease. The α-galactosidase A gene analysis, however, showed no mutation. Although specific physical symptoms were solely short stature and oligomenorrhea, the diagnosis of Turner syndrome was confirmed by the chromosome analysis which showed mosaicism of 45XO and 46X,r(X) (60%:40%). To our knowledge, this is the first report of Turner syndrome with "T1 pulvinar sign".

  2. The prevalence and features of the polycystic ovary syndrome in young South Indian women from Pondicherry

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    Willis G. Sheelaa

    2014-04-01

    Full Text Available Background: Aim of current study was to correlate clinical presentation of menstrual irregularity with ultrasound ovarian morphology and assess prevalence of occult PCO. Methods: Fifty women in the age group of 15-25 years attending gynaecology OPD with the complaints of menstrual irregularity were selected for the study. Fifty women within the same age group without any of these complaints were enrolled as control. Results: Past In study group 80% were obese, 50% had acne, 26% had hirsutism, 94% had oligomenorrhea, 80% had ovarian morphological changes and 6% had amenorrhea. In the control group 48% were obese and 46% had ovarian changes. Conclusions: Occult PCOD category need follow up and laboratory assays, as they have risk of PCOD and long term implications like diabetes, hypertension, dyslipidemia and cardiovascular disease. [Int J Reprod Contracept Obstet Gynecol 2014; 3(2.000: 344-346

  3. New adolescent polycystic ovary syndrome perspectives.

    Science.gov (United States)

    Alemzadeh, R; Kansra, A R

    2011-02-01

    Polycystic ovary syndrome (PCOS) is a common but heterogeneous disorder that usually arises during puberty. This endocrine disorder is associated with chronic anovulation and hyperandrogenemia with clinical manifestation of oligomenorrhea, hirsutism and acne. While the underlying etiology of PCOS remains unknown, it is commonly associated with obesity and insulin resistance leading to increased risk of cardiovascular disease, dyslipidemia and type 2 diabetes mellitus in hyperandrogenemic phenotypes. Menstrual irregularities and insulin resistance in obese adolescents are usually indistinguishable from the clinical manifestations of PCOS and pose a diagnostic dilemma due to higher circulating androgens during puberty. Consequently, a universal consensus on the definition of hyperandrogenemia in adolescents has been elusive. Nevertheless, hyperandrogenemia, independent of obesity, in postmenarchal adolescents is associated with increased risk of cardiometabolic syndrome. Therefore, treatment strategies including lifestyle changes and/or use of insulin-sensitizers, hormone replacement and antiandrogens should be utilized in order to delay long-term cardiovascular and metabolic complications of this endocrinopathy.

  4. Tamoxifen and ovarian function.

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    Martine Berliere

    Full Text Available BACKGROUND: Some studies suggest that the clinical parameter "amenorrhea" is insufficient to define the menopausal status of women treated with chemotherapy or tamoxifen. In this study, we investigated and compared the ovarian function defined either by clinical or biological parameters in pre-menopausal breast cancer patients treated with tamoxifen administered as adjuvant therapy. MATERIALS AND METHODS: Between 1999 and 2003, 138 premenopausal patients consecutively treated for early breast cancer were included. Sixty-eight received tamoxifen in monotherapy as the only adjuvant systemic treatment (Group I and 70 were treated with tamoxifen after adjuvant chemotherapy (Group II. All patients had a confirmed premenopausal status based on clinical parameters and hormonal values at study entry. They were followed prospectively every 3 months for 3 years: menses data, physical examination and blood tests (LH, FSH, 17-beta-estradiol. Vaginal ultrasonography was carried out every 6 months. After 3 years, prospective evaluation was completed and monitoring of ovarian function was performed as usual in our institution (1x/year. All data were retrospectively evaluated in 2011. RESULTS: Three patients were excluded from the study in group I and 2 were excluded in group II. Patients were divided into 4 subgroups according to clinical data, i.e. menses patterns. These patterns were assessed by questionnaires. a: Regular menses (>10 cycles/year b: Oligomenorrhea (5 to 9 cycles/year c: Severe oligomenorrhea (1 to 4 cycles/year d: Complete amenorrhea Estrogen levels did not appear to have any impact on disease-free survival rates after 3 or 8 years. FSH values were also documented and analyzed. They exhibited the same profile as estradiol values. CONCLUSIONS: Amenorrhea is an insufficient parameter to define menopausal status in patients receiving tamoxifen. Low estradiol levels must be coupled with other biological parameters to characterize endocrine status

  5. [Menstrual disorders. Is this a problem to be handled by occupational medicine physician?].

    Science.gov (United States)

    Makowiec-Dabrowska, Teresa; Hanke, Wojciech; Sprusińska, Elzbieta; Radwan-Włodarczyk, Zyta; Koszada-Włodarczyk, Wiesława

    2004-01-01

    The aim of the study was to define the frequency of menstrual disorders and identify risk factors, especially those associated with the work environment. The study group was composed of 142 women, aged 22-45 years. Some of them were employed in a cosmetics manufacture plant and a bank, others were hospital and ambulatory nurses and auxiliary personnel. The study revealed irregular cycles in one third and prolonged bleeding in one fourth of the women. Long cycles were observed in one fifth of the women and short cycles were noted in every tenth women. It was found that occasional or frequent contact with ethylene oxide increased the risk of irregular cycles and oligomenorrhea, whereas work around X-ray apparatus was responsible for the risk of long cycles and heavy bleeding. Long rest pauses during work (in this study correlated with work load) were regarded as a factor inducing the risk of oligomenorrhea and prolonged bleeding. A randomly sampled group of 33 women measured morning temperature during two consecutive cycles. Of this number, 15 women (45.5%) showed ovulation in both cycles, 11 (33.3%) in one cycle only, and 7 both anovulatory cycles. The risk of ovulation disorders was enhanced by a two-shift work system (mostly night shift) and strong job stress. Energy expenditure for leisure time activity > 1000 kcal/week and smoking also contributed to an enhanced risk. In summing up, it should be stressed that because of varied frequency of irregular cycles determined by the intensity of environmental factors, occupational medicine physicians should gather data on the occurrence of such disorders and undertake relevant preventive measures.

  6. Ovarian structural disturbances in epilectic patients treated with Sodium valproate

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    Yousefi N.

    2008-03-01

    Full Text Available Background: Recent studies have raised the issue of an increased incidence of polycystic ovaries (PCO and menstrual disturbances in women with epilepsy treated with valproate (VPA. It seems that antiepileptic drugs, especially valproate, may have a functional role in altering the endocrine system of child-bearing women with epilepsy. We conducted this study to investigate the association of VPA and ovarian structural/menstrual disorders in epileptic women.Methods: In this cross-sectional study, we compared a total of 64 epileptic patients, aged 16-45 years, 32 of whom had been taking VPA alone and 32 were on other antiepileptic drugs for a minimum duration of six months. Ovarian sonography was performed and body mass index (BMI calculated for all subjects. We also recorded the presence of menstrual disturbances in both groups.Results: Fifteen (46% of the VPA subjects had PCO compared to 7 (21.9% of the other group. In the VPA group, four (12.5% had oligomenorrhea, one (3.1% amenorrhea and 13 (40.6% had irregular menstrual cycles. However, from the other group, two (6.3% subjects had oligomenorrhea and seven (21.9% had irregular menstrual cycles; amenorrhea was not present in the non-VPA treated patients. Mean BMI was 22.5 kg/m2 among the VPA subjects and 20.1 kg/m2 in the non-VPA subjects.Conclusions: This study supports the association of PCO and high BMI with VPA treatment. The frequency of menstrual disturbances did not differ significantly between the two groups.

  7. Treatment of hyperprolactinemia: a systematic review and meta-analysis

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    Wang Amy T

    2012-07-01

    Full Text Available Abstract Background Hyperprolactinemia is a common endocrine disorder that can be associated with significant morbidity. We conducted a systematic review and meta-analyses of outcomes of hyperprolactinemic patients, including microadenomas and macroadenomas, to provide evidence-based recommendations for practitioners. Through this review, we aimed to compare efficacy and adverse effects of medications, surgery and radiotherapy in the treatment of hyperprolactinemia. Methods We searched electronic databases, reviewed bibliographies of included articles, and contacted experts in the field. Eligible studies provided longitudinal follow-up of patients with hyperprolactinemia and evaluated outcomes of interest. We collected descriptive, quality and outcome data (tumor growth, visual field defects, infertility, sexual dysfunction, amenorrhea/oligomenorrhea and prolactin levels. Results After review, 8 randomized and 178 nonrandomized studies (over 3,000 patients met inclusion criteria. Compared to no treatment, dopamine agonists significantly reduced prolactin level (weighted mean difference, -45; 95% confidence interval, -77 to −11 and the likelihood of persistent hyperprolactinemia (relative risk, 0.90; 95% confidence interval, 0.81 to 0.99. Cabergoline was more effective than bromocriptine in reducing persistent hyperprolactinemia, amenorrhea/oligomenorrhea, and galactorrhea. A large body of noncomparative literature showed dopamine agonists improved other patient-important outcomes. Low-to-moderate quality evidence supports improved outcomes with surgery and radiotherapy compared to no treatment in patients who were resistant to or intolerant of dopamine agonists. Conclusion Our results provide evidence to support the use of dopamine agonists in reducing prolactin levels and persistent hyperprolactinemia, with cabergoline proving more efficacious than bromocriptine. Radiotherapy and surgery are useful in patients with resistance or intolerance

  8. Different types of menstrual cycle and their significance in Chinese women diagnosed with polycystic ovary syndrome according to the Rotterdam consensus criteria%基于鹿特丹标准诊断的多囊卵巢综合征患者月经类型及其意义

    Institute of Scientific and Technical Information of China (English)

    徐兴华; 谭迎春; 石玉华; 王斌; 鞠秀清; 郑庆梅; 郝翠芳; 陈子江

    2009-01-01

    目的 分析基于鹿特丹标准诊断的中国人多囊卵巢综合征(PCOS)患者不同月经类型的临床资料及内分泌代谢指标,以指导临床治疗.方法 将符合鹿特丹标准的2100例PCOS患者按闭经、月经稀发、月经规律进行分组,分别进行代谢及内分泌等指标的比较.结果 (1)闭经组多毛、多囊卵巢发生率均高于月经稀发组(P<0.01).(2)闭经组的血清搞睾酮最高,月经稀发组最低(P<0.01);黄体生成素(LH)在闭经组最高(P<0.01),在月经稀发组和月经规律组问差异无统计学意义(P>0.05);黄体生成素/卵泡刺激素(LH/FSH)在月经规律组增高明显(P<0.01).(3)口服葡萄糖后2 h血糖在闭经组显著增高(P<0.01).结论 符合鹿特丹标准的不同月经类型的PCOS患者具有不同的临床表现及代谢、内分泌特点,对于不同月经类型PCOS患者的治疗也应该个体化.%Objective To analyze the clinical and metabolic characteristics of Chinese women with different menstrual types.All the women were diagnosed with polycystic ovary syndrome according to the Rotterdam consensus criteria.Methods A total of 2100 patients were divided into three groups:amenorrhea,oligomenorrhea and regular menstruation.The metabolism and endocrine indices were determined and compared among three groups.Results (1)The incidences of hirsutism and PCO were obviously higher in the amenorrhea group than in the oligomenorrhea roup(P<0.01).(2)The amenorrhea group had the highest level of serum testosterone while the oligomenorrhea group had the lowest.Moreover,the level of luteinizing hormone(LH)was higher in the amenorrhea group than in the other two groups(P<0.01).However the ratio of LH/FSH increased significantly in the regular menstruation group (P<0.01).(3)The value of 2 h blood glucose was the highest in the amenorrhea group(P<0.01).Conclusion PCOS patients with diverse types of menstrual cycle show difierent clinical manifestations and

  9. HUBUNGAN DISTRES DAN KADAR KORTISOL DENGAN KEJADIAN OLIGO-AMENOREA PADA NARAPIDANA DI LEMBAGA PEMASYARAKATAN WANITA SESUMATERA BARAT

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    Yaslinda Yaunin

    2010-09-01

    oligomenorrhea and amenorrhea. The design of this study is analytic-descriptive studies with subjects prisoner women in WestARTIKEL PENELITIAN139Sumatera,age 20-40, no physical illnes, has normal menstruation before in the prison and BMI normal range.The result showed that cortisol level in the morning is significantly different between depression and non depression subjects. There are no different cortisol level in the afternoon between depression and non depression subjects, and also no different cortisol level women with disregulation menstruation and women with normal menstruation. There are no relationship between disregulation menstruation and depression.Key word : Depression,Cortisol, Oligomenorrhea

  10. Epidemiology, diagnosis, and management of polycystic ovary syndrome.

    Science.gov (United States)

    Sirmans, Susan M; Pate, Kristen A

    2013-12-18

    Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by irregular menses, hyperandrogenism, and polycystic ovaries. The prevalence of PCOS varies depending on which criteria are used to make the diagnosis, but is as high as 15%-20% when the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria are used. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Risk factors for PCOS in adults includes type 1 diabetes, type 2 diabetes, and gestational diabetes. Insulin resistance affects 50%-70% of women with PCOS leading to a number of comorbidities including metabolic syndrome, hypertension, dyslipidemia, glucose intolerance, and diabetes. Studies show that women with PCOS are more likely to have increased coronary artery calcium scores and increased carotid intima-media thickness. Mental health disorders including depression, anxiety, bipolar disorder and binge eating disorder also occur more frequently in women with PCOS. Weight loss improves menstrual irregularities, symptoms of androgen excess, and infertility. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Spironolactone and finasteride are used to treat symptoms of androgen excess. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology. Recent data suggest that letrozole and metformin may play an important role in ovulation induction. Proper diagnosis and management of PCOS is essential to address patient concerns but also to prevent future metabolic, endocrine, psychiatric, and cardiovascular complications.

  11. 多囊卵巢综合征父/母系亲属遗传表型的分析%Analysis of phenogenetic correlation of polycystic ovary syndrome from agnate and maternal relatives

    Institute of Scientific and Technical Information of China (English)

    李晓红; 李国屏; 陈湘梅; 易红; 李瑾

    2012-01-01

    Objective: To investigate the phenogenetic correlation of polycystic ovary syndrome (PCOS) in agnate/maternal first-degree and second-degree relatives. Methods: A total of 882 patients with PCOS who attended to the reproductive health clinic of Bao'an Maternal and Children's Health Hospital from Oct. 2004 to May 2011 were investigated. The frequency rate of some biomedical parameters both in agnate and maternal first-degree and second-degree relatives was compared. The agnate and maternal first-degree and second-degree relatives of infertile women with normal menstruation cycle and without PCOS were as control group. The data of obesity, hypertension, diabetes mellitus, abnormal menstruation, oligomenorrhea and amenorrhea were recorded and compared. Results: In agnate and maternal first-degree and second-degree relatives, the accidence of obesity, hypertension, diabetes mellitus, oligomenorrhea in patients with PCOS were higher than those in patients without PCOS (P 0. 05). However, the incidences of obesity and oligomenorrhea in maternal were significantly higher than those in the agnate (Poligomenorrhea in the maternal relatives may be the major genetic factors for suffering PCOS in offspring. The psychological factor is another risk and important factor.%目的 探讨多囊卵巢综合征(PCOS)患者的发病与其父系、母系一、二级亲属遗传表型的相关性,为该病的预测和预防提供理论依据. 方法 采用家系调查量表,收集2004年10月~2011年5月在本院生殖健康科门诊就诊882例PCOS患者的父系、母系一、二级亲属的临床资料为研究组及同期660例月经规律、B超示双侧卵巢无多囊改变的育龄期妇女父系、母系一、二级亲属的临床资料为对照组,比较肥胖、高血压、糖尿病、月经稀发在父系、母系一、二级亲属间的发生

  12. Academic stress and menstrual disorders among female undergraduates in Uyo, South Eastern Nigeria - the need for health education.

    Science.gov (United States)

    Ekpenyong, C E; Davis, K J; Akpan, U P; Daniel, N E

    2011-12-20

    The aim of this study was to determine the association between academic stress and menstrual disorders among female undergraduates in Uyo, South Eastern Nigeria. Three hundred and ninety-three (393) female students of the University of Uyo, ages between 16 and 35 years were randomly selected from different departments in the University, and studied during the 2009/2010 academic session. Menstrual history and Student's Stress Assessment Questionnaire (SSAQ) were used for this assessment. They were distributed for participants to fill out. Prevalence of menstrual disorder among participants was 34.6%. A direct association between menstrual disorder and academic stress was observed. Commonest menstrual disorder was menorrhagia (37.5%). Others were: Pre-menstrual Syndrome (PMS 33.1%), Oligomenorrhea 19.9% and amenorrhea 5.9% (Pacademic stress had about 2 times chances of having menstrual disorders (OR : 2.0, C.I = 1.224-2.837) at Pacademic stress and menstrual disorder among females undergraduate in Uyo, South Eastern Nigeria.

  13. Hirsutism: Clinico-investigative profile of 50 Indian patients

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    Sharma Nand

    2008-01-01

    Full Text Available Background: Despite worldwide prevalence of hirsutism studies on hirsutism in Indian patients are not many. Aims: This retrospective study was carried out to assess the clinico-investigative profile of patients presenting with hirsutism. Materials and Methods: Medical records of 82 hirsutism patients diagnosed consecutively during July 2005 to October 2007 were analyzed. Results: The complete data of 50 patients aged between 13 and 47 years were available. Fifty percent patients were aged 20 to 30 years. The average F-G score was 10.3 ± 2.46. Associated signs of hyperandrogenism were acne (64%, oligomenorrhea or menstrual irregularities (36%, androgenetic alopecia (16%, acanthosis nigricans (6% and seborrhea (4%. Polycystic ovaries were detected in 30% patients and 22% patients had elevated serum free testosterone levels. Family history of hirsutism was present in 18% patients. Conclusion: Hirsutism in Indian patients is not uncommon. Adolescent patients appear to be more concerned about hirsutism as compared to those in the older age group who were more often worried of late onset acne. All patients, however, were more concerned for facial hair than those on other body areas signifying that facial hair need to be given higher than current value in F-G score.

  14. Evaluating dysmenorrhea in a sample of Turkish nursing students.

    Science.gov (United States)

    Seven, Memnun; Güvenç, Gülten; Akyüz, Aygül; Eski, Fatma

    2014-09-01

    The aim of this study was to determine the prevalence and symptoms of dysmenorrhea, its relevant factors, and the rate of seeking medical help in a group of nursing students. A total of 380 students were included in the study. The demographic data questionnaire, a Daily Menstrual Symptom Rating Scale (DMSR), and the Visual Analog Scale for pain (VASP) were used as tools for data collection. The mean age of the participants was 20.31 ± 1.10 years. Most students had experienced dysmenorrhea (84.9%). Menstrual pain was frequently initiated on the first day of menstruation (77.8%). The most commonly reported menstrual problems were irregular menstrual cycles (27.2%) and oligomenorrhea (15.1%). Only 24.1% of students consulted their physicians for dysmenorrhea. The participants who had dysmenorrhea had significantly higher symptom scores than the participants who had not had dysmenorrhea, in terms of decreased activities, tension, hip and abdominal pain, backache, headache, and fatigue. Also, having a sister with dysmenorrhea increased the risk of dysmenorrhea. Although dysmenorrhea is a gynecological problem that is commonly seen in young women and that negatively affects daily activities and school life, the rate of seeking medical help is low. Adolescents should, therefore, be educated and counseled to determine the underlying cause and to increase the use of an effective treatment method. Considering that nurses should be better informed about dysmenorrhea causes and treatment options, a study of nursing students was undertaken.

  15. Menstrual Irregularities and Related Plasma Hormone Levels in Multiple Sclerosis Patients Treated with Beta Interferone

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    Ehya Garshasbi

    2010-02-01

    Full Text Available Multiple sclerosis is a chronic inflammatory disease of central nervous system.Women are more susceptible to this disease. One of the obvious clinical complaints in women with multiple sclerosis specially treated with Beta Interferones is menstrual cycle irregularity. The aim of this study was to determine the prevalence of menstrual irregularities and probable changes in blood levels of related hormones (FSH, LH, PRL, TSH, T4, T3 in 58 females with definite MS treated with beta interferones versus 58 healthy women. In comparison to the control group, the patients had higher prevalence of irregular menstruation (P=0.001, oligomenorrhea (p=0.03, abnormal amount of menstrual blood flow (P=0.001, abnormal duration of menstrual flow (P=0.01 and missed period (P=0.04. Mean LH level in patients group was higher than control group (P=0.04.Hyperprolactinemia (>25.5ng/ml was more prevalent in patients group .There were not a significant difference in plasma levels of FSH and thyroid hormones between two groups. There were some relations between the type of Beta interferones and the subtype of menstrual irregularities in the patients. In conclusion, the results of this study emphasized the high rate of menstrual problem and changes of related plasma hormone levels in MS patients.

  16. Efficacy of Prophylactic Uterine Artery Embolization before Obstetrical Procedures with High Risk for Massive Bleeding

    Science.gov (United States)

    Ko, Heung Kyu; Ko, Gi Young; Gwon, Dong Il; Kim, Jin Hyung; Han, Kichang; Lee, Shin-Wha

    2017-01-01

    Objective To evaluate the safety and efficacy of prophylactic uterine artery embolization (UAE) before obstetrical procedures with high risk for massive bleeding. Materials and Methods A retrospective review of 29 female patients who underwent prophylactic UAE from June 2009 to February 2014 was performed. Indications for prophylactic UAE were as follows: dilatation and curettage (D&C) associated with ectopic pregnancy (cesarean scar pregnancy, n = 9; cervical pregnancy, n = 6), termination of pregnancy with abnormal placentation (placenta previa, n = 8), D&C for retained placenta with vascularity (n = 5), and D&C for suspected gestational trophoblastic disease (n = 1). Their medical records were reviewed to evaluate the safety and efficacy of UAE. Results All women received successful bilateral prophylactic UAE followed by D&C with preservation of the uterus. In all patients, UAE followed by obstetrical procedure prevented significant vaginal bleeding on gynecologic examination. There was no major complication related to UAE. Vaginal spotting continued for 3 months in three cases. Although oligomenorrhea continued for six months in one patient, normal menstruation resumed in all patients afterwards. During follow-up, four had subsequent successful natural pregnancies. Spontaneous abortion occurred in one of them during the first trimester. Conclusion Prophylactic UAE before an obstetrical procedure in patients with high risk of bleeding or symptomatic bleeding may be a safe and effective way to manage or prevent serious bleeding, especially for women who wish to preserve their fertility. PMID:28246515

  17. Clinical characteristics and presence of prolactinoma in women with hyperprolactinemia

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    López-Clavijo, Carlos Alberto

    2016-07-01

    Full Text Available Objectives: To clinically characterize women with hyperprolactinemia at InSer Pereira (Colombia and to determine the prevalence of prolactinoma. Methods: Retrospective description of 45 patients with hyperprolactinemia, and contrasted pituitary magnetic resonance (MR, between January 2008 and July 2013. Clinical manifestations, etiology, serum prolactin level, and MR findings were included. Results: The most frequent clinical manifestations were: infertility, galactorrhea, oligomenorrhea. There were 26 cases of prolactinoma (57.8 %, and 12 of idiopathic hyperprolactinemia (26.6 %. Out of the 26 prolactinomas, 23 were microadenomas (average size 5.1 mm; SD ± 3.2 mm. Average serum prolactin level was 74.05 ng/mL (SD ± 13.33 ng/mL. 78 % of patients with prolactinoma had serum prolactin level under 70.0 ng/mL. No significant association was found between serum prolactin level and the presence of prolactinoma. Conclusion: Prolactinomas are the main cause of hyperprolactinemia and they are found mostly with slight rise of serum prolactin. Pituitary MRI is recommended in patients with hyperprolactinemia, regardless of their prolactin level.

  18. Clinical characterization of patients with macroprolactinemia and monomeric hyperprolactinemia

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    Murat Can

    2011-05-01

    Full Text Available Macroprolactinemia is often a cause of misdiagnosis, unnecessary expensive investigation, and unsuitable treatment. The aim of the present study was to investigate the clinical findings and the concentrations of macroprolactin in patients with hyperprolactinemia in our region. Eighty-four female hyperprolactinemic patients were screened for macroprolactinemia. Prolactin was measured by chemiluminesans method on an Immulite 2000 analyzer (Siemens Health Diagnostics, Deerfield, IL, USA. Recoveries less than or equal to 40% after polyethylene glycol precipitation were indicative of macroprolactinemia. Clinical features and biochemical values were compared in true hyperprolactinemic and macroprolactinemic patients. Macroprolactinemia was detected in 31 patients (36.9%, with 84 hyperprolactinemic female patients. There was no difference in frequency of galactorrhea and oligomenorrhea/amenorrhea between the two groups. When we evaluated the clinical features of patients according to prolactin levels, no significant difference was found between the groups. In conclusion, our initial data show that no clinical features could reliably differentiate macroprolactinemic from true hyperprolactinemic patients, but at least one of these symptoms was present in most macroprolactinemic patients.

  19. Polycystic ovary syndrome: clinical and laboratory evaluation

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    Marcos Yorghi Khoury

    Full Text Available OBJECTIVE: To evaluate clinically, and with laboratory, tests, women with polycystic ovary syndrome (PCO. PATIENTS: One hundred and twelve women with PCO were studied. METHODS: The following data was recorded: Current age; age at menarche; menstrual irregularity, occurrence of similar cases in the family; fertility, obstetric history; body mass index (BMI; and presence of hirsutism. Serum measurements of follicle stimulating hormone (FSH, luteinizing hormone (LH, prolactin, free testosterone, and dehydroepiandrosterone sulfate were taken. RESULTS: All patients presented either oligomenorrhea (31 percent, periods of secondary amenorrhea (9 percent, or both alterations (60 percent. The majority of the patients were infertile (75.6 percent. The LH/FSH ratio was higher than 2:1 in 55 percent of the patients and higher than 3:1 in 26.2 percent. The ultrasonographic aspect of the ovaries was considered to be normal in 31 percent. CONCLUSION: The main clinical feature of the PCO is the irregularity of menses since menarche, and that the laboratory tests would be important to exclude other disorders such as hyperprolactinemia or hyperandrogenemia caused by late-onset congenital adrenal hyperplasia.

  20. Women With Polycystic Ovary Syndrome Have Comparable Hip Bone Geometry to Age-Matched Control Women.

    Science.gov (United States)

    McBreairty, Laura E; Zello, Gordon A; Gordon, Julianne J; Serrao, Shani B; Pierson, Roger A; Chizen, Donna R; Chilibeck, Philip D

    2016-12-26

    Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. The oligomenorrhea and amenorrhea characteristic to PCOS are associated with low bone mineral density (BMD); conversely, the hyperandrogenism and hyperinsulinemia may elicit a protective effect on BMD. As bone geometric properties provide additional information about bone strength, the objective of this study was to compare measures of hip geometry in women with PCOS to a healthy female population. Using dual-energy X-ray absorptiometry, BMD and measures of hip geometry were determined in women with PCOS (n = 60) and healthy controls (n = 60) aged 18-35 years. Clinical biochemical measures were also determined in women with PCOS. Measures of hip geometry, including cross-sectional area, cross-sectional moment of inertia, subperiosteal width (SPW), and section modulus, were similar between groups following correction for body mass index (BMI) (all p > 0.05) with intertrochanter SPW significantly lower in women with PCOS (p geometry in women with PCOS. Copyright © 2016 International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.

  1. Menstrual-Cycle and Menstruation Disorders in Episodic vs Chronic Migraine: An Exploratory Study.

    Science.gov (United States)

    Spierings, Egilius L H; Padamsee, Aliya

    2015-07-01

    Migraine is a chronic condition of recurring moderate-to-severe headaches that affects an estimated 6% of men and 18% of women. The highest prevalence is in those 18-49 years of age, generally when women menstruate. It is divided into episodic and chronic migraine depending on the total number of headache days per month being 14 or less or 15 or more, respectively. Migraine has been associated with menorrhagia, dysmenorrhea, and endometriosis, the latter particularly in chronic migraine. We conducted a questionnaire survey of 96 women with migraine, 18-45 years old, to determine the occurrence of the menstrual-cycle disorders, oligomenorrhea, polymenorrhea, and irregular cycle, and the menstruation disorders, dysmenorrhea and menorrhagia, in episodic vs chronic migraine. The prevalence of menstrual-cycle disorders in general (41.2 vs 22.2%) and dysmenorrhea (51.0 vs 28.9%) was statistically significantly higher in the women with chronic migraine than in those with episodic migraine (P ≤ 0.05) (not corrected for multiple comparisons). Whether the migraine was menstruation sensitive, that is, the headaches consistently occurred or worsened with menstruation, did not impact the prevalence of menstrual disorders. We conclude that chronic migraine is possibly more often than episodic migraine associated with menstrual-cycle disorders in general and dysmenorrhea, without impact on menstruation sensitivity of the headaches. Wiley Periodicals, Inc.

  2. The menstrual cycle regularization following D-chiro-inositol treatment in PCOS women: a retrospective study.

    Science.gov (United States)

    La Marca, Antonio; Grisendi, Valentina; Dondi, Giulia; Sighinolfi, Giovanna; Cianci, Antonio

    2015-01-01

    Polycystic ovary syndrome is characterized by irregular cycles, hyperandrogenism, polycystic ovary at ultrasound and insulin resistance. The effectiveness of D-chiro-inositol (DCI) treatment in improving insulin resistance in PCOS patients has been confirmed in several reports. The objective of this study was to retrospectively analyze the effect of DCI on menstrual cycle regularity in PCOS women. This was a retrospective study of patients with irregular cycles who were treated with DCI. Of all PCOS women admitted to our centre, 47 were treated with DCI and had complete medical charts. The percentage of women reporting regular menstrual cycles significantly increased with increasing duration of DCI treatment (24% and 51.6% at a mean of 6 and 15 months of treatment, respectively). Serum AMH levels and indexes of insulin resistance significantly decreased during the treatment. Low AMH levels, high HOMA index, and the presence of oligomenorrhea at the first visit were the independent predictors of obtaining regular menstrual cycle with DCI. In conclusion, the use of DCI is associated to clinical benefits for many women affected by PCOS including the improvement in insulin resistance and menstrual cycle regularity. Responders to the treatment may be identified on the basis of menstrual irregularity and hormonal or metabolic markers.

  3. Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes.

    Science.gov (United States)

    Li, Yu; Pan, Ping; Yuan, Ping; Qiu, Qi; Yang, Dongzi

    2016-09-06

    Resistant ovary syndrome (ROS) is a rare endocrine disorder characterized with hypergonadotrophic hypogonadism. Infertility is a common complaint of woman presenting with ROS, and little progress has been made in term of reproduction with the patient's own gamete. So far only one case report of live birth has been reported after in vitro maturation (IVM) of oocytes in a patient suffering from ROS in 2013. A secondary infertile woman of 33 years-old was manifested with oligomenorrhea and markedly increased gonadotropin levels around postmenopausal range, but had normal antral follicle count, normal serum inhibin B and anti-Müllerian hormone levels. She had normal karyotype of 46,XX and normal thyroid function. There were no abnormal findings in some autoantibody assays and FSH receptor sequencing. After oral contraceptive pills combined with triptorelin depot were administered, her gonadotropin levels reduced but it showed no response to high doses of exogenous gonadotropins (hp-HMG 300IU/d for 15 days). Then endometrium was prepared with estradiol valerate and IVM from small antral follicles were performed. Five immature oocytes were retrieved. Twenty-four hours after IVM culture, 3 oocytes matured to metaphase II stage and were inseminated by intracytoplasmic sperm injection using her husband's sperm. Two top-quality embryos were transferred and one embryo was cryopreserved. The patient got pregnant and delivered a healthy boy at term. IVM using their own oocytes could be an available treatment for infertile women with ROS.

  4. Efficacy of prophylactic uterine artery embolization before obstetrical procedures with high risk for massive bleeding

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Heung Kyu; Shin, Ji Hoon; Ko, Gi Young; Gwon, Dong Il; Kim, Jin Hyung; Han, Ki Chang; Lee, Shin Wha [Asan Medical Center, Ulsan University College of Medicine, Seoul (Korea, Republic of)

    2017-04-15

    To evaluate the safety and efficacy of prophylactic uterine artery embolization (UAE) before obstetrical procedures with high risk for massive bleeding. A retrospective review of 29 female patients who underwent prophylactic UAE from June 2009 to February 2014 was performed. Indications for prophylactic UAE were as follows: dilatation and curettage (D and C) associated with ectopic pregnancy (cesarean scar pregnancy, n = 9; cervical pregnancy, n = 6), termination of pregnancy with abnormal placentation (placenta previa, n = 8), D and C for retained placenta with vascularity (n = 5), and D and C for suspected gestational trophoblastic disease (n = 1). Their medical records were reviewed to evaluate the safety and efficacy of UAE. All women received successful bilateral prophylactic UAE followed by D and C with preservation of the uterus. In all patients, UAE followed by obstetrical procedure prevented significant vaginal bleeding on gynecologic examination. There was no major complication related to UAE. Vaginal spotting continued for 3 months in three cases. Although oligomenorrhea continued for six months in one patient, normal menstruation resumed in all patients afterwards. During follow-up, four had subsequent successful natural pregnancies. Spontaneous abortion occurred in one of them during the first trimester. Prophylactic UAE before an obstetrical procedure in patients with high risk of bleeding or symptomatic bleeding may be a safe and effective way to manage or prevent serious bleeding, especially for women who wish to preserve their fertility.

  5. [Hyperprolactinemia unrelated to prolactinoma].

    Science.gov (United States)

    Krysiak, Robert; Okopień, Bogusław

    2014-01-01

    Hyperprolactinemia, defined as prolactin levels above the upper limit of normal range, is the most frequent hypothalamus-pituitary dysfunction. Clinical symptoms of hyperprolactinemia in women include oligomenorrhea, infertility, and galactorrhea, while in men the condition may lead to hypogonadism, decreased libido, erectile dysfunction, infertility, gynecomastia, and, in rare instances, galactorrhea. In many patients, hyperprolactinemia results from the presence of prolactinoma, which is considered as the most common hormone-secreting pituitary tumors. However, transient or long-term hyperprolactinemia may also develop during different physiological situations or due to several diseases. It is also a frequent but often neglected side effect of many drugs, particularly of antipsychotics. Finally, hyperprolactinemia may be secondary to the predominance of high molecular mass circulating prolactin forms that have been postulated to represent complexes of prolactin and anti-prolactin immunoglobulins (macroprolactinemia). The cause of hyperprolactinemia determines its treatment. In this paper, we review the causes of hyperprolactinemia unrelated to prolactinoma, providing a differential diagnosis of this condition.

  6. Analysis of endometrial hyperplasia in patients with polycystic ovarian syndrome%多囊卵巢综合征患者子宫内膜增生相关因素的分析

    Institute of Scientific and Technical Information of China (English)

    涂彬彬; 张秋芳; 闫丽盈; 乔杰

    2011-01-01

    Objective;To explore the incidence and predictive fators of endometrial hy-perplasia( EH) in polycystic ovarian syndrome( PCOS) patients. Methods; 160 PCOS patients and 80 non-PCOS patients with tubal or male infertility as control group were involved in the study. The pathologic role of PCOS in EH was studied. The incidence of EH was compared between the two groups and among the subtypes of PCOS patients; and the relationship between clinical characteristics and EH in PCOS patients was explored. Results;The incidence of EH in oligomenorrhea group and hyperandrogenism group was significantly elevated ( P59天或超声子宫内膜回声异常时,EH发生率显著升高(P=0.005,P=0.003).结论:月经稀发和高雄激素血症在EH中发挥重要作用,只存在月经稀发或高雄激素血症的可疑PCOS患者亦应重视其子宫内膜病变.PCOS患者EH发生率增高,尤其是月经周期>59天或存在子宫内膜回声异常者,应高度警惕子宫内膜病变.

  7. Markers of insulin resistance and sedentary lifestyle are predictors of preeclampsia in women with adverse obstetric results

    Directory of Open Access Journals (Sweden)

    S. Hoirisch-Clapauch

    2011-12-01

    Full Text Available Some thrombophilias and severe preeclampsia may increase the risk for preterm deliveries and fetal death due to placental insufficiency. Our objective was to evaluate clinical and laboratory data as predictors of preeclampsia in a population of mothers with 3rd trimester fetal losses or preterm deliveries. In a longitudinal retrospective study, 54 consecutive women (age range: 16 to 39 years with normotensive pregnancies were compared to 79 consecutive women with preeclampsia (age range: 16 to 43 years. Weight accrual rate (WAR was arbitrarily defined as weight gain from age 18 years to the beginning of pregnancy divided by elapsed years. Independent predictors of preeclampsia were past history of oligomenorrhea, WAR >0.8 kg/years, pre-pregnancy or 1st trimester triglyceridemia >150 mg/dL, and elevated acanthosis nigricans in the neck. In a multivariate logistic regression model, two or more predictors conferred an odds ratio of 15 (95%CI [5.9-37]; P < 0.001 to develop preeclampsia (85% specificity, 73% sensitivity, c-statistic of 81 ± 4%; P < 0.0001. Clinical markers related to insulin resistance and sedentary lifestyles are strong independent predictors of preeclampsia in mothers with 3rd trimester fetal losses or preterm deliveries due to placental insufficiency. Women at risk for preeclampsia in this particular population might benefit from measures focused on overcoming insulin resistance.

  8. Mosaic variegated aneuploidy associated with a dysmorphic syndrome and mental handicap

    Energy Technology Data Exchange (ETDEWEB)

    Mehta, L.; Babu, A.; Willner, J. [Sount Sinai Sachool of Medicine, New York, NY (United States)] [and others

    1994-09-01

    A 41-year-old woman was evaluated for dysmorphic features and mental handicap. Prior karyotyping had revealed 7% mosaicism for trisomy 18 in skin fibroblasts with normal blood chromosomes. Clinical features consisted of short stature, mild mental retardation, sensorineural deafness and the following dysmorphic features: short, broad neck, low posterior hairline, small palpebral fissures with iris coloboma on the right, epicanthic folds, small mouth, high palate and prominent mandible, short metacarpals and digits, particularly the fifth, with bilateral simian creases. Medical problems included non-insulin dependent diabetes mellitus, hypertension, oligomenorrhea and recent onset of diabetic neuropathy and retinal exudates. Head size and brain MRI were within normal limits. Peripheral blood chromosomes revealed: 46,XX (45 cells), 46,XX,t(7;16)(q21;q21) in 1 cell, 45,X (1 cell), 48,XXXX (1 cell), 47,XX,+mar (1 cell), 48,XX,+mar,+mar (1 cell). Skin fibroblasts revealed the following karyotypes: 46,XX (25 cells), 45,X (14 cells), 47,XX,+2 (10 cells) and 47,X,+2,+7 (1 cell). Previously reported cases of mosaic variegated aneuploidy include microcephaly as a prominent feature. Chromosomes involved in the abnormality are variable. Clinical presentations in such patients are not consistent and do not appear to correlate with specific chromosome defects. This patient represents an interesting example of probable mitotic instability disrupting normal developmental processes.

  9. Markers of insulin resistance and sedentary lifestyle are predictors of preeclampsia in women with adverse obstetric results

    Directory of Open Access Journals (Sweden)

    S. Hoirisch-Clapauch

    2011-12-01

    Full Text Available Some thrombophilias and severe preeclampsia may increase the risk for preterm deliveries and fetal death due to placental insufficiency. Our objective was to evaluate clinical and laboratory data as predictors of preeclampsia in a population of mothers with 3rd trimester fetal losses or preterm deliveries. In a longitudinal retrospective study, 54 consecutive women (age range: 16 to 39 years with normotensive pregnancies were compared to 79 consecutive women with preeclampsia (age range: 16 to 43 years. Weight accrual rate (WAR was arbitrarily defined as weight gain from age 18 years to the beginning of pregnancy divided by elapsed years. Independent predictors of preeclampsia were past history of oligomenorrhea, WAR >0.8 kg/years, pre-pregnancy or 1st trimester triglyceridemia >150 mg/dL, and elevated acanthosis nigricans in the neck. In a multivariate logistic regression model, two or more predictors conferred an odds ratio of 15 (95%CI [5.9-37]; P < 0.001 to develop preeclampsia (85% specificity, 73% sensitivity, c-statistic of 81 ± 4%; P < 0.0001. Clinical markers related to insulin resistance and sedentary lifestyles are strong independent predictors of preeclampsia in mothers with 3rd trimester fetal losses or preterm deliveries due to placental insufficiency. Women at risk for preeclampsia in this particular population might benefit from measures focused on overcoming insulin resistance.

  10. Level of Anxiety, Depression, Self-Esteem, Social Anxiety, and Quality of Life among the Women with Polycystic Ovary Syndrome

    Directory of Open Access Journals (Sweden)

    Gökhan Açmaz

    2013-01-01

    Full Text Available Introduction. Polycystic ovary syndrome (PCOS is a heterogeneous disease and many symptoms are seen with varying degrees. The aim of the present study was to determine which symptoms increased such problems as depression, anxiety, low self-esteem, and social worry by classifying PCOS according to symptoms. Methods. The study was carried out with two groups. The first group consisted of 86 patients who were diagnosed with PCOS and the second group consisted of 47 healthy volunteers. Liebowitz’ Social Anxiety Scale, Rosenberg’ Self-Esteem Scale, Short-Form 36, Quality of Life Scale, Beck Anxiety Inventory, and Beck Depression Inventory were administered to each volunteer. Results. Depression scores of infertile group were higher while anxiety scores of the obese group were bigger than other groups. It was the obesity group that received the smallest score in self-esteem and trust in people and the highest score in sensitiveness to criticism. The most affected group was oligomenorrhea-hirsutism group in terms of physical functioning, physical role function, pain, social functioning, emotional role function, and emotional well-being. Conclusion. We suggest that not only gynecologist but also a multidisciplinary team may examine these patients.

  11. Evaluation of Clinical Features of Female Patients with Macroprolactinemia

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    Göksun Ayvaz

    2011-09-01

    Full Text Available Aim: Macroprolactin is a high-molecular-weight form of prolactin. It has been suggested that macroprolactin has no clinical importance because of its decreased or limited bioactivity. Although screening for macroprolactinemia is recommended especially in patients with idiopathic hyperprolactinemia; recent studies reported that patients with macroprolactinemia may have some hyperprolactinemia symptoms. Currently, the causes of the symptoms as well as the treatment and follow-up of this group of patients are not clear. In our study, we aimed to retrospectively evaluate and compare the clinical characteristics and gonadal hormone levels of patients with macroprolactinemia and hyperprolactinemia.Materials and Methods: Forty patients with macroprolactinemia and 15 patients with hyperprolactinemia who referred to Obstetrics and Gynecology Hospital were examined.Results: We observed that the patients with macroprolactinemia had similar menstrual disturbances (oligomenorrhea/amenorrhea to the patients with hyperprolactinemia. There was no statistically significant difference between the two groups with respect to FSH, LH and estradiol levels. The frequencies of galactorrhea (p=0.002, headache (p=0.04 and positive radiological finding (p=0.001 were higher in patients with hyperprolactinemia. Infertility rate was found to be increased in women with macroprolactinemia (p=0.02.Conclusion: Patients with macroprolactinemia may have very similar clinic symptoms to those with hyperprolactinemia. Therefore, macroprolactin levels should be measured regardless of the symptoms of hyperprolactinemia in patients with elevated prolactin levels. Türk Jem 2011; 15: 62-5

  12. Hyperprolactinemia

    Directory of Open Access Journals (Sweden)

    Abha Majumdar

    2013-01-01

    Full Text Available Prolactin (PRL is an anterior pituitary hormone which has its principle physiological action in initiation and maintenance of lactation. In human reproduction, pathological hyperprolactinemia most commonly presents as an ovulatory disorder and is often associated with secondary amenorrhea or oligomenorrhea. Galactorrhea, a typical symptom of hyperprolactinemia, occurs in less than half the cases. Out of the causes of hyperprolactinemia, pituitary tumors may be responsible for almost 50% of cases and need to be investigated especially in the absence of history of drug induced hyperprolactinemia. In women with hyperprolactinemic amenorrhea one important consequence of estrogen deficiency is osteoporosis, which deserves specific therapeutic consideration. Problem in diagnosing and treating hyperprolactinemia is the occurrence of the ′big big molecule of prolactin′ that is biologically inactive (called macroprolactinemia, but detected by the same radioimmunoassay as the biologically active prolactin. This may explain many cases of very high prolactin levels sometimes found in normally ovulating women and do not require any treatment. Dopamine agonist is the mainstay of treatment. However, presence of a pituitary macroadenoma may require surgical or radiological management.

  13. Acne and hirsutism in polycystic ovary syndrome: clinical, endocrine-metabolic and ultrasonographic differences.

    Science.gov (United States)

    Falsetti, L; Gambera, A; Andrico, S; Sartori, E

    2002-08-01

    The aim of this study was to investigate whether the absence or presence of acne or hirsutism in 248 women with polycystic ovary syndrome was associated with different clinical, endocrine, metabolic and ultrasonographic factors. Patients were divided into three groups: 96 (38.7%) without any androgenic symptoms; 94 (37.9%) with only hirsutism; and 58 (23.4%) with only acne. The cycle alterations (oligomenorrhea or amenorrhea) and the echographic ovarian morphology (polycystic or multifollicular ovaries) showed no significant differences between the three groups. Hirsutism was associated with a greater incidence of obesity and insulin resistance, with an increase of 17-hydroxyprogesterone, ovarian and adrenal androgens, 3alpha-androstanediol glucuronide, insulin, insulin-like growth factor-I and low luteinizing hormone, sex hormone binding globulins and insulin-like growth factor binding protein-1 levels. Acne was associated only with the lowest 3alpha-androstanediol glucuronide levels. Therefore, two different pathogenetic mechanisms may play a role in the onset of acne and hirsutism.

  14. Markers of insulin resistance and sedentary lifestyle are predictors of preeclampsia in women with adverse obstetric results.

    Science.gov (United States)

    Hoirisch-Clapauch, S; Benchimol-Barbosa, P R

    2011-12-01

    Some thrombophilias and severe preeclampsia may increase the risk for preterm deliveries and fetal death due to placental insufficiency. Our objective was to evaluate clinical and laboratory data as predictors of preeclampsia in a population of mothers with 3rd trimester fetal losses or preterm deliveries. In a longitudinal retrospective study, 54 consecutive women (age range: 16 to 39 years) with normotensive pregnancies were compared to 79 consecutive women with preeclampsia (age range: 16 to 43 years). Weight accrual rate (WAR) was arbitrarily defined as weight gain from age 18 years to the beginning of pregnancy divided by elapsed years. Independent predictors of preeclampsia were past history of oligomenorrhea, WAR >0.8 kg/years, pre-pregnancy or 1st trimester triglyceridemia >150 mg/dL, and elevated acanthosis nigricans in the neck. In a multivariate logistic regression model, two or more predictors conferred an odds ratio of 15 (95%CI [5.9-37]; P < 0.001) to develop preeclampsia (85% specificity, 73% sensitivity, c-statistic of 81 ± 4%; P < 0.0001). Clinical markers related to insulin resistance and sedentary lifestyles are strong independent predictors of preeclampsia in mothers with 3rd trimester fetal losses or preterm deliveries due to placental insufficiency. Women at risk for preeclampsia in this particular population might benefit from measures focused on overcoming insulin resistance.

  15. Analysis of the Correlation Between Serum Sex Hormones and Thyroid Function in Patients with Menstrual Disorder%月经紊乱患者血清性激素及甲状腺功能的相关分析

    Institute of Scientific and Technical Information of China (English)

    蔡铁铁

    2014-01-01

    【目的】探讨月经紊乱患者血清性激素与甲状腺功能的相关性。【方法】选取200例月经紊乱患者(观察组)和200例健康体检者(对照组),检测两组性激素六项及游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)三项,分析甲状腺功能与月经紊乱的相关性。【结果】观察组与对照组 FT3、FT4、TSH比较无显著性差异( P >0.05),但观察组与对照组甲状腺功能减退(甲减)的发生率比较有统计学差异( P<0.05);观察组甲减以月经稀发为主,其次为月经过多;亚临床甲减以月经稀发为主;甲状腺功能亢进(甲亢)以月经过少为主;亚临床甲亢以月经过少和过多为主。【结论】甲状腺功能的紊乱能够引起女性月经失调,甲状腺功能的检测对月经紊乱有一定的指导意义。%[Objective] To explore the relationship between serum sex hormone and thyroid function in patients with menstrual disorder .[Methods] Totally 200 patients with menstrual disorder (observation group) and 200 healthy subjects (control group) were chosen .Six sex hormones and FT3 ,FT4 and TSH in two groups were measured .The correlation between serum sex hormones and thyroid function were analyzed .[Results] There was no significant difference in FT 3 , FT4 and TSH between observation group and control group ( P<0 .05) ,while there was significant difference in the inci-dence rate of hypothyroidism between observation group and control group ( P<0 .05) .The major symptom of hypothy-roidism was oligomenorrhea ,and the second was hypermenorrhea .The major symptom of subclinical hypothyroidism was oligomenorrhea ,and that of hyperthyroidism was hypomenorrhea .The major symptoms of subclinical hyperthyroidism were hypomenorrhea and hypermenorrhea .[Conclusion] Thyroid dysfunction can cause menstrual disorder in women . The detection of thyroid function is of the

  16. Spironolactone in the treatment of polycystic ovary syndrome: effects on clinical features, insulin sensitivity and lipid profile.

    Science.gov (United States)

    Zulian, E; Sartorato, P; Benedini, S; Baro, G; Armanini, D; Mantero, F; Scaroni, C

    2005-01-01

    This prospective clinical trial was designed to assess the effects of a long-term therapy with spironolactone, with and without dietary-induced weight-loss, on clinical features, lipid profile and insulin levels in women with polycystic ovary syndrome (PCOS). Twenty-five patients (range of age 16-32 yr; 13 lean and 12 overweight) fulfilling formal diagnostic criteria for PCOS (oligomenorrhea and/or amenorrhea, biochemical and/or clinical evidence of hyperadrogenism) were studied at baseline and then received oral spironolactone (100 mg/die) for 12 months; association with lifestyle modifications was recommended to all over-weight patients. Clinical, endocrine and metabolic parameters [oral glucose tolerance test (OGTT), lipid profile] were measured at baseline and at the end of the antiandrogen treatment. The therapy was associated with a significant average decline of triglycerides in overweight subjects and with increased HDL-cholesterol levels in lean patients. The insulin levels at 60 min during OGTT, homeostasis model assessment-insulin resistance and area under curve of insulin were significantly lowered in overweight women after 12 months of spironolactone and weight loss and no negative changes in insulin secretion and sensitivity were observed in PCOS women after pharmacological treatment alone. The efficacy of spironolactone on the androgenic clinical aspects of PCOS has been confirmed in this study. Furthermore, our data show that long-term treatment with spironolactone exerts no negative effects on lipoprotein profile and glucose metabolism; more relevant beneficial effects on glucose and lipid metabolism were observed when the antiandrogen was associated with weight loss in overweight PCOS women.

  17. Polycystic ovary syndrome in patients on antiepileptic drugs

    Science.gov (United States)

    Viswanathan, Lakshminarayanapuram G.; Satishchandra, Parthasarathy; Bhimani, Bipin C.; Reddy, Janardhan YC; Rama Murthy, Batchu S.; Subbakrishna, Doddaballapura K.; Sinha, Sanjib

    2016-01-01

    Objective: This study aims to discuss the prevalence of polycystic ovary (PCO) and Polycystic ovary syndrome (PCOS) in women with epilepsy (WWE) on valproate (VPA), carbamazepine (CBZ), or phenobarbitone (PB), drug naive WWE and women with bipolar affective disorder (BPAD) on VPA. Materials and Methods: This prospective study included 190 women aged 18–45 years, who had epilepsy or BPAD (on VPA), and consented for study. Patients were grouped as Group 1 (n = 40): WWE on VPA, Group 2 (n = 50): WWE on CBZ, Group 3 (n = 50): WWE on PB, Group 4 (n = 30): drug naïve WWE, and Group 5 (n = 20): women with BPAD on VPA. All women were interviewed for medical, menstrual, drug and treatment history, nature of epilepsy, and seizure control. Chi-square test and Fisher's exact test were done to compare results between the groups. Results: Fifty-two women (52/190; 27.4%) had menstrual disturbances, in which oligomenorrhea was the most common (55.8%). There was a significant difference in the occurrence of PCOS in patients on VPA versus normal population (P = 0.05) and patients on other antiepileptic drugs (AEDs) (P = 0.02). There was, however, no significant difference in the occurrence of PCO between patients on VPA and the untreated epileptic women. VPA group (Epilepsy + BPAD) had a significantly higher occurrence of obesity than other treatment groups (P = 0.043, OR = 2.11). Conclusions: The study observed significantly higher occurrence of PCO in patients on VPA compared to other AEDs and the normal population. The importance of proper clinical evaluation before initiating VPA is highlighted. PMID:27570385

  18. Role of the levonorgestrel intrauterine system in effective contraception

    Directory of Open Access Journals (Sweden)

    Attia AM

    2013-08-01

    Full Text Available Abdelhamid M Attia,1 Magdy M Ibrahim,1 Ahmed M Abou-Setta21Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt; 2George and Fay Yee Centre for Healthcare Innovation, University of Manitoba/Winnipeg Regional Health Authority, Winnipeg, MB, CanadaAbstract: Norgestrel, a synthetic progestin chemically derived from 19-nortestosterone, is six times more potent than progesterone, with variable binding affinity to various steroid receptors. The levonorgestrel-releasing intrauterine system (LNG IUS provides a long-acting, highly effective, and reversible form of contraception, with a pearl index of 0.18 per 100 women-years. The locally released hormone leads to endometrial concentrations that are 200–800 times those found after daily oral use and a plasma level that is lower than that with other forms of levonorgestrel-containing contraception. The contraceptive effect of the LNG IUS is achieved mainly through its local suppressive effect on the endometrium, leading to endometrial thinning, glandular atrophy, and stromal decidualization without affecting ovulation. The LNG IUS is generally well tolerated. The main side effects are related to its androgenic activity, which is usually mild and transient, resolving after the first few months. Menstrual abnormalities are also common but well tolerated, and even become desirable (eg, amenorrhea, hypomenorrhea, and oligomenorrhea with proper counseling of the patient during the choice of the method of contraception. The satisfaction rates after 3 years of insertion are high, reaching between 77% and 94%. The local effect of the LNG IUS on the endometrium and low rates of systemic adverse effects have led to its use in other conditions rather than contraception, as for the treatment of endometrial hyperplasia, benign menorrhagia, endometriosis, adenomyosis, and uterine fibroids.Keywords: levonorgestrel, intrauterine device, contraception, family planning, Mirena, Skyla

  19. 硫氧还蛋白相互作用蛋白与多囊卵巢综合征代谢紊乱的研究进展%The Research Progress of Thioredoxin-interacting Protein and Metabolic Disorder in Polycystic Ovary Syndrome

    Institute of Scientific and Technical Information of China (English)

    徐小平(综述); 周晓梅(审校)

    2016-01-01

    多囊卵巢综合征( PCOS)是一种复杂的生殖内分泌疾病,主要特征为月经稀发或闭经、高雄激素血症、卵巢多囊样改变以及代谢紊乱。其中,胰岛素抵抗在PCOS患者中很常见。高糖通过糖类反应元件增加了血清硫氧还蛋白相互作用蛋白( TXNIP)的表达,导致胰岛素抵抗,从而加强了氧化应激,引起β细胞凋亡。由于 PCOS 妇女血清 TXNIP 水平较正常妇女明显偏高,因此通过探究TXNIP 与PCOS的相关性,可以为寻找PCOS代谢紊乱治疗靶点提供新的依据与线索。%Polycystic ovary syndrome(PCOS) is a complex reproductive endocrine disease,and its main characteristics are oligomenorrhea or amenorrhea,hyperandrogenemia,polycystic ovary change,and metabolic disorders,particularly that insulin resistance is common in PCOS patients.Hyperglycemia increases the expression of serum thioredoxin-interacting protein ( TXNIP) with carbohydrate response element,which cau-ses insulin resistance and βcell apoptosis by enhancing the oxidative stress.Serum thioredoxin-interacting protein levels of PCOS women are significantly higher than the normal women.By exploring the relationship between TXNIP and PCOS correlation,the new evidence and clues for the treatment of PCOS metabolic disor-der will be found.

  20. Research Progress on the Correlation between Vitamin D and Metabolic Disorder in Polycystic Ovary Syndrome%维生素D与多囊卵巢综合征代谢紊乱的研究进展

    Institute of Scientific and Technical Information of China (English)

    孙明雅(综述); 周晓梅(审校)

    2015-01-01

    Polycystic ovary syndrome(PCOS) is a complex reproductive endocrine disease,and its main characteristics are oligomenorrhea or amenorrhea, hyperandrogenemia,and polycystic ovary sample changes. Metabolic disorders, particularly insulin resistance and dyslipidemia are common in patients with PCOS . Existing evidence suggests that there is a correlation between vitamin D status and metabolic disorders of patients with PCOS.Serum vitamin D levels of PCOS women are significantly lower than normal women . Improving the level of vitamin D in PCOS women may lead to the improvement of metabolic disorders in P-COS patients.Here is to make a review of the latest research progress on the correlation between vitamin D and metabolic disorder in PCOS.%多囊卵巢综合征( PCOS)是一种复杂的生殖内分泌疾病,主要特征是月经稀发或闭经、高雄激素血症以及卵巢多囊样改变。代谢紊乱,尤其是胰岛素抵抗和血脂异常在 PCOS患者很常见。PCOS患者维生素D状态与代谢紊乱存在相关性。 PCOS妇女血清维生素D水平较正常妇女明显偏低,提高维生素D水平可能有助于PCOS患者体内代谢紊乱的改善。该文就维生素 D与PCOS代谢紊乱的最新研究进展予以综述。

  1. The Prevalence of Polycystic Ovary Syndrome (PCOS in High School Students in Rasht in 2009 According to NIH Criteria

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    Maryam Asgharnia

    2011-01-01

    Full Text Available Background: Polycystic ovary syndrome (PCOS is the most common endocrine disorder inwomen associated with many reproductive, endocrine, metabolic and cardiovascular dysfunctions.This study aimed to determine the prevalence of PCOS among high school students in Rasht.Materials and Methods: In a cross–sectional study, 1850 students were selected by a multi-stage clustersampling from all high schools in Rasht. The inclusion criteria were: age 17-18 years, menarche from10-16 years, normal prolactin and thyroid stimulating hormone (TSH values, no history of anatomicalmalformation, no use of medication or hair-removal techniques, and a history of oligo- or amenorrhea.PCOS was diagnosed if both menstrual dysfunction and clinical hyperandrogenism were detected.Results: Mean age of subjects was 17.2 ± 0.7 years and the age of menarche was 12.8 ± 0.9 years. Ofall students, 378 (20.4% had oligomenorrhea and PCOS was diagnosed in 210 (11.34 % accordingto the National Institute of Health (NIH definition. PCOS subjects, mean body mass index (BMI,waist circumference, and waist/hip (W/H ratio were 21.1 ± 3.6, 73.4 ± 8.0 cm and 0.77 ± 0.05,respectively. A family history of diabetes mellitus type 2 was reported in 24.7% of subjects.Conclusion: The prevalence of PCOS in this study was similar to the international estimatesof 10-20% in Caucasians. A long-term follow-up is needed to compare the accuracy of clinicaldetermination of the disease versus diagnosis based on hormonal and/or sonographic assessments.

  2. Onset of menstrual cycle and menses features among secondary school girls in Italy: A questionnaire study on 3,783 students

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    Vincenzo De Sanctis

    2014-01-01

    Full Text Available Premise: Healthcare professionals need updated information about what is the range of "normal" variation of menstrual cycle features to support young girls and their parents in managing reproductive health, and to detect diseases early. Materials and Methods: This cross-sectional study aimed to provide an updated picture of age at menarche and main menstrual cycle characteristics and complaints in an Italian population-based sample of 3,783 adolescents attending secondary school. Girls filled in a self-administered anonymous questionnaire including questions about demography, anthropometry, smoking and drinking habits, use of contraceptive, socioeconomic status, age at menarche, menstrual pattern, and physical/psychological menstrual complaints. Mean age at menarche and prevalence of polymenorrhea (cycle length 35 days, irregularity, dysmenorrhea, and of physical/psychological complaints were computed. Factors associated with age at menarche and menstrual disturbances were explored by using multiple logistic models. Results: The girls′ mean age was 17.1 years (SD 1.4 years and the mean age at menarche was 12.4 years (SD 1.3 years; menarche occurred with two monthly peaks of frequency in July-September and in December-January (P 6 days was shown in 19.6% of girls. Gynecological age was significantly associated with cycle length (P < 0.0001 with long cycles becoming more regular within the fourth year after menarche, while frequency of polymenorrhea stabilized after the second gynecological year. Oligomenorrhea and irregularity were both significantly associated with long menstrual bleeding (adjusted OR = 2.36; 95% CI = 1.55-3.60, and adjusted OR = 2.59; 95% CI = 1.95-3.44, respectively. Conclusions: The findings of the study support the levelling-off of secular trend in menarche anticipation in Italy and confirm the timing in menstrual cycle regularization. The study provides updated epidemiological data on frequency of menstrual abnormalities

  3. Female athlete triad and its components: toward improved screening and management.

    Science.gov (United States)

    Javed, Asma; Tebben, Peter J; Fischer, Philip R; Lteif, Aida N

    2013-09-01

    As female athletic participation has increased, the positive effects of exercise on health have become evident. However, with this growth in sports activity, a set of health problems unique to the female athlete has emerged. The female athlete triad as first described in 1992 by the American College of Sports Medicine consisted of disordered eating, amenorrhea, and osteoporosis; the definition was updated in 2007 to include a spectrum of dysfunction related to energy availability, menstrual function, and bone mineral density. For this review, a comprehensive search of databases-MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Scopus, from earliest inclusive dates to January 2013-was conducted by an experienced librarian with input from the authors. Controlled vocabulary supplemented with keywords such as female athlete triad, amenorrhea, oligomenorrhea, fracture, osteopenia, osteoporosis, bone disease, anorexia, bulimia, disordered eating, low energy availability was used to search for articles on female athlete triad. Articles addressing the prevalence, screening, and management of the female athlete triad were selected for inclusion in the review. This article reviews the current definitions of the triad components, epidemiology, pathophysiology, and recommended screening and management guidelines. The lack of efficacy of current screening of athletes is highlighted. Low energy availablity, from either dietary restriction or increased expenditure, plays a pivotal role in development of the triad. Athletes involved in "lean sports" (those that emphasize weight categories or aesthetics, such as ballet, gymnastics, or endurance running) are at highest risk. Treatment is centered on restoring energy availability to reverse adverse changes in the metabolic milieu. Prevention and early recognition of triad disorders are crucial to ensure timely intervention

  4. PAPSS2 Deficiency Causes Androgen Excess via Impaired DHEA Sulfation—In Vitro and in Vivo Studies in a Family Harboring Two Novel PAPSS2 Mutations

    Science.gov (United States)

    Oostdijk, Wilma; Idkowiak, Jan; Mueller, Jonathan W.; House, Philip J.; Taylor, Angela E.; O'Reilly, Michael W.; Hughes, Beverly A.; de Vries, Martine C.; Kant, Sarina G.; Santen, Gijs W. E.; Verkerk, Annemieke J. M. H.; Uitterlinden, André G.; Wit, Jan M.; Losekoot, Monique

    2015-01-01

    Context: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3′-phospho-adenosine-5′-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA). Impaired DHEA sulfation is thought to increase the conversion of DHEA toward active androgens, a proposition supported by the previous report of a girl with inactivating PAPSS2 mutations who presented with low serum DHEA sulfate and androgen excess, clinically manifesting with premature pubarche and early-onset polycystic ovary syndrome. Patients and Methods: We investigated a family harboring two novel PAPSS2 mutations, including two compound heterozygous brothers presenting with disproportionate short stature, low serum DHEA sulfate, but normal serum androgens. Patients and parents underwent a DHEA challenge test comprising frequent blood sampling and urine collection before and after 100 mg DHEA orally, with subsequent analysis of DHEA sulfation and androgen metabolism by mass spectrometry. The functional impact of the mutations was investigated in silico and in vitro. Results: We identified a novel PAPSS2 frameshift mutation, c.1371del, p.W462Cfs*3, resulting in complete disruption, and a novel missense mutation, c.809G>A, p.G270D, causing partial disruption of DHEA sulfation. Both patients and their mother, who was heterozygous for p.W462Cfs*3, showed increased 5α-reductase activity at baseline and significantly increased production of active androgens after DHEA intake. The mother had a history of oligomenorrhea and chronic anovulation that required clomiphene for ovulation induction. Conclusions: We provide direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation. Heterozygosity for PAPSS2 mutations can be associated with a phenotype resembling polycystic ovary syndrome. PMID:25594860

  5. Polycystic Ovary Syndrome in University Students: Occurrence and Associated Factors

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    Amita Attlee

    2014-11-01

    Full Text Available Background: The aim of this study was to assess the occurrence of polycystic ovary syndrome (PCOS and its association with body composition among students in University of Sharjah (UOS. Materials and Methods: This cross-sectional study included a total sample size of 50 female students registering in undergraduate programs at the University of Sharjah using convenience sampling technique. A pretested interview schedule was administered to elicit information pertaining to personal background and medical history related to PCOS. A diagnostic ultrasound scan was performed for determining PCOS along with a body composition analysis using bioelectrical impedance analysis (BIA technology. Results: Twenty percent (10 out of 50 participants were diagnosed with PCOS, of whom only 4 individuals were previously diagnosed with PCOS and aware of their conditions, while the reports showed 16% with oligomenorrhea, 4% with polymenorrhea, and none with amenorrhea. A positive family history was indicated as reported by 22% of the total participants. Significant difference between the body weights of participants having PCOS (66.7 kg and those without it (58.8 kg were noted (p=0.043, t=2.084. On the other hand, the body composition related variables including waist-hip ratio (WHR, fat-free mass (FFM, percent body fat (PBF and visceral fat area (VFA were relatively higher in participants having PCOS than those without it. However, there was no statistical significance of differences. Comparatively, the participants with PCOS had lower bone mineral density (BMD than those without it, whereas the difference was statistically non-significant. Conclusion: The occurrence of PCOS in the present study is consistent with the global prevalence. Comparatively, the body composition of PCOS females is different from the normal females. Further studies are required in the Middle East region on larger sample sizes and broader aspects of health including lifestyle and dietary

  6. The role of acupuncture-moxibustion in ovulation induction based on theChinese Medicine and Acupuncture-moxibustion Databank%基于《中医针灸信息库》探讨针灸促排卵

    Institute of Scientific and Technical Information of China (English)

    常翠芳; 张淑静; 黄琴峰; 张翠红

    2016-01-01

    Ovulatory dysfunction refers to absent ovulation or luteal insufficiency. It is commonly seen in women with irregular menstruation or menstrual cycles, especially in those with oligomenorrhea or amenorrhea. Ovulatory dysfunction is considered the single-most frequent cause of female infertility. Clinically, the two major causes of ovulatory dysfunction are polycystic ovarian syndrome (PCOS) and luteinized unruptured follicle syndrome (LUFS). Acupuncture-moxibustion improves ovulation and helps with infertility. Through a systematic review and analysis on relevant literatures in Chinese Medicine and Acupuncture-moxibustion Databankover the last decade, this paper summarized the characteristics and pattern of acupuncture-moxibustion points for improving ovulation in order to provide an optimal acupuncture-moxibustion protocol in this regard.%排卵障碍是指无排卵或黄体功能异常,在月经周期及经量紊乱,特别是稀发或闭经时常见,是女性不孕症的主要原因之一。临床实践中所接触到的排卵障碍女性中,多囊卵巢综合征(PCOS)患者所占比例最高,其次为黄素化未破裂卵泡综合征(LUFS)。针灸促排卵是中医治疗不孕症的一大特色。基于《中医针灸信息库》对近10年的相关文献进行系统回顾与分析,总结针灸促排卵选穴的特点及规律,以期探索制定出针灸促排卵的最优化方案。

  7. Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.

    Directory of Open Access Journals (Sweden)

    Michelle R Jones

    2015-08-01

    Full Text Available Genome wide association studies (GWAS have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS, a common disorder in young women characterized by androgen excess and oligomenorrhea. To put these risk loci and the single nucleotide polymorphisms (SNPs therein into functional context, we measured DNA methylation and gene expression in subcutaneous adipose tissue biopsies to identify PCOS-specific alterations. Two genes from the LHCGR region, STON1-GTF2A1L and LHCGR, were overexpressed in PCOS. In analysis stratified by obesity, LHCGR was overexpressed only in non-obese PCOS women. Although not differentially expressed in the entire PCOS group, INSR was underexpressed in obese PCOS subjects only. Alterations in gene expression in the LHCGR, RAB5B and INSR regions suggest that SNPs in these loci may be functional and could affect gene expression directly or indirectly via epigenetic alterations. We identified reduced methylation in the LHCGR locus and increased methylation in the INSR locus, changes that are concordant with the altered gene expression profiles. Complex patterns of meQTL and eQTL were identified in these loci, suggesting that local genetic variation plays an important role in gene regulation. We propose that non-obese PCOS women possess significant alterations in LH receptor expression, which drives excess androgen secretion from the ovary. Alternatively, obese women with PCOS possess alterations in insulin receptor expression, with underexpression in metabolic tissues and overexpression in the ovary, resulting in peripheral insulin resistance and excess ovarian androgen production. These studies provide a genetic and molecular basis for the reported clinical heterogeneity of PCOS.

  8. Familial Mediterranean fever and its implications for fertility and pregnancy.

    Science.gov (United States)

    Mijatovic, Velja; Hompes, Peter G A; Wouters, Maurice G A J

    2003-06-10

    Familial Mediterranean fever (FMF) is a recessively inherited disease of episodic fever in combination with severe abdominal pain, pleurisy, arthritis or erysipelas-like skin rashes. The disease is mainly prevalent in Sephardic Jews, Armenians, Turks and Arabs. The gene responsible for FMF was cloned in 1997. The gene expresses a protein called pyrin which is believed to play a role in the downregulation of mediators of inflammation. Several mutations have been identified of which the homozygous form of the M694V mutation is associated with a more severe expression of FMF. Prophylactic administration of colchicine is effective in relieving most patients from their attacks and preventing the development of amyloidosis, which usually leads to end-stage renal disease. Unfortunately, there is little awareness of the disease in gynaecological practice although a FMF full blown episode may mimic an acute abdominal calamity suggesting several possible gynaecological diagnoses. FMF is also associated with subfertility. In females, infertility was mainly related to oligomenorrhea although the causes remain unclear. In male FMF patients, progression of the disease may induce testicular impairment, consequently affecting spermatogenesis. Some controversy exists as to the adverse effects of colchicine on sperm production and function although the impression is that the occurrence of sperm pathology in FMF patients, using the recommended dosage of colchicine, is very low. In pregnant FMF patients, an increased occurrence of miscarriage has been found. However, the mechanisms involved remain unclear. Although colchicine is a mitotic inhibitor and transplacental crossing of colchicine has been demonstrated, no increased risk of foetal abnormalities in colchicine-treated pregnant FMF patients has been found. Therefore, amniocentesis should not be done for reassurance alone.

  9. Phytotherapy and women's reproductive health: the Cameroonian perspective.

    Science.gov (United States)

    Njamen, Dieudonne; Mvondo, Marie Alfrede; Djiogue, Sefirin; Ketcha Wanda, Germain Jean Magloire; Magne Nde, Chantal Beatrice; Vollmer, Günter

    2013-05-01

    Approximately 80 % of the population in Africa use traditional medicinal plants to improve their state of health. The reason of such a wide use of medicinal plants has been mainly attributed to their accessibility and affordability. Expectation of little if any side effects, of a "natural" and therefore safe treatment regimen, as well as traditional beliefs additionally contribute to their popularity. Several of these plants are used by women to relieve problems related to their reproductive health, during or after their reproductive life, during pregnancy, or following parturition. The African pharmacopoeia thus provides plants used for preventing and/or treating gynecological infections, dysmenorrhea, irregular menstruations, oligomenorrhea or protracted menstruation, and infertility. Such plants may then be used as antimicrobians, emmenagogues, or as suppressors of uterine flow. African medicinal plants are also used during pregnancy for prenatal care, against fetal malposition or malpresentation, retained dead fetus, and against threatened abortion. Some others are used as anti-fertilizing drugs for birth control. Such plants may exert various activities, namely, anti-implantation or early abortifacient, anti-zygotic, blastocytotoxic, and anti-ovulatory effects. Some herbs could also act as sexual drive suppressors or as a post-coital contraceptive by reducing the fertility index. A number of these plants have already been subject to scientific investigations and many of their properties have been assessed as estrogenic, oxytocic, or anti-implantation. Taking into account the diversity of the African pharmacopoeia, we are still at an early stage in the phytochemical and pharmacological characterization of these medicinal plants that affect the female reproductive system, in order to determine, through in vitro and in vivo studies, their pharmacological properties and their active principles.

  10. Obstetrics and gynecology outpatient scenario of an Indian homeopathic hospital: A prospective, research-targeted study.

    Science.gov (United States)

    Saha, Subhranil; Koley, Munmun; Saha, Sangita; Singh, Rakesh; Hossain, Md Monowar; Pramanik, Indrani

    2016-04-01

    The authors aimed to document prescriptions and clinical outcomes in routine homeopathic practice to short list promising areas of targeted research and efficacy trials of homeopathy in obstetrics and gynecology (O&G). Three homeopathic physicians participated in methodical data collection over a 3-month period in the O&G outpatient setting of The Calcutta Homeopathic Medical College and Hospital, West Bengal, India. A specifically designed Excel spreadsheet was used to record data on consecutive appointments, including date, patient identity, socioeconomic status, place of abode, religion, medical condition/complaint, whether chronic/acute, new/follow-up case, patient-assessed outcome (7-point Likert scale: -3 to +3), prescribed homeopathic medication, and whether other medication/s was being taken for the condition. These spreadsheets were submitted monthly for data synthesis and analysis. Data on 878 appointments (429 patients) were collected, of which 61% were positive, 20.8% negative, and 18.2% showed no change. Chronic conditions (93.2%) were chiefly encountered. A total of 434 medical conditions and 52 varieties were reported overall. The most frequently treated conditions were leucorrhea (20.5%), irregular menses (13.3%), dysmenorrhea (10%), menorrhagia (7.5%), and hypomenorrhea (6.3%). Strongly positive outcomes (+3/+2) were mostly recorded in oligomenorrhea (41.7%), leucorrhea (34.1%), polycystic ovary (33.3%), dysmenorrhea (28%), and irregular menses (22.2%). Individualized prescriptions predominated (95.6%). A total of 122 different medicines were prescribed in decimal (2.9%), centesimal (87.9%), and 50 millesimal potencies (4.9%). Mother tinctures and placebo were prescribed in 3.4% and 30.4% instances, respectively. Several instances of medicine-condition pairings were detected. This systematic recording cataloged the frequency and success rate of treating O&G conditions using homeopathy.

  11. Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.

    Science.gov (United States)

    Jones, Michelle R; Brower, Meredith A; Xu, Ning; Cui, Jinrui; Mengesha, Emebet; Chen, Yii-Der I; Taylor, Kent D; Azziz, Ricardo; Goodarzi, Mark O

    2015-08-01

    Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea. To put these risk loci and the single nucleotide polymorphisms (SNPs) therein into functional context, we measured DNA methylation and gene expression in subcutaneous adipose tissue biopsies to identify PCOS-specific alterations. Two genes from the LHCGR region, STON1-GTF2A1L and LHCGR, were overexpressed in PCOS. In analysis stratified by obesity, LHCGR was overexpressed only in non-obese PCOS women. Although not differentially expressed in the entire PCOS group, INSR was underexpressed in obese PCOS subjects only. Alterations in gene expression in the LHCGR, RAB5B and INSR regions suggest that SNPs in these loci may be functional and could affect gene expression directly or indirectly via epigenetic alterations. We identified reduced methylation in the LHCGR locus and increased methylation in the INSR locus, changes that are concordant with the altered gene expression profiles. Complex patterns of meQTL and eQTL were identified in these loci, suggesting that local genetic variation plays an important role in gene regulation. We propose that non-obese PCOS women possess significant alterations in LH receptor expression, which drives excess androgen secretion from the ovary. Alternatively, obese women with PCOS possess alterations in insulin receptor expression, with underexpression in metabolic tissues and overexpression in the ovary, resulting in peripheral insulin resistance and excess ovarian androgen production. These studies provide a genetic and molecular basis for the reported clinical heterogeneity of PCOS.

  12. Polycystic ovary syndrome in patients on antiepileptic drugs

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    Lakshminarayanapuram G Viswanathan

    2016-01-01

    Full Text Available Objective: This study aims to discuss the prevalence of polycystic ovary (PCO and Polycystic ovary syndrome (PCOS in women with epilepsy (WWE on valproate (VPA, carbamazepine (CBZ, or phenobarbitone (PB, drug naive WWE and women with bipolar affective disorder (BPAD on VPA. Materials and Methods: This prospective study included 190 women aged 18-45 years, who had epilepsy or BPAD (on VPA, and consented for study. Patients were grouped as Group 1 (n = 40: WWE on VPA, Group 2 (n = 50: WWE on CBZ, Group 3 (n = 50: WWE on PB, Group 4 (n = 30: drug naοve WWE, and Group 5 (n = 20: women with BPAD on VPA. All women were interviewed for medical, menstrual, drug and treatment history, nature of epilepsy, and seizure control. Chi-square test and Fisher′s exact test were done to compare results between the groups. Results: Fifty-two women (52/190; 27.4% had menstrual disturbances, in which oligomenorrhea was the most common (55.8%. There was a significant difference in the occurrence of PCOS in patients on VPA versus normal population (P = 0.05 and patients on other antiepileptic drugs (AEDs (P = 0.02. There was, however, no significant difference in the occurrence of PCO between patients on VPA and the untreated epileptic women. VPA group (Epilepsy + BPAD had a significantly higher occurrence of obesity than other treatment groups (P = 0.043, OR = 2.11. Conclusions: The study observed significantly higher occurrence of PCO in patients on VPA compared to other AEDs and the normal population. The importance of proper clinical evaluation before initiating VPA is highlighted.

  13. Clinical and Biochemical Evaluation of Subacute (De Ouervain's Thyroiditis

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    M Fariduddin

    2011-02-01

    Full Text Available Background: Subacute thyroiditis is an important cause of thyrotoxicosis, often misdiagnosed as Graves’ disease and given anti-thyroid drugs. Etiological diagnosis can yield proper guideline of management and a good result. Objectives: To see the clinical, biochemical and isotope profile of subacute thyroiditis. Methods: A total of 45 cases [36 females, 9 males; age (mean ± SD: 33± 4.7 yr] were recruited from Endocrine outpatient department of Bangabandhu Sheikh Mujib Medical University (BSMMU to see thyroid hormones and isotope scan. Results: Most of the patients had a history of sore throat (84.4%. All had painful thyroid gland with or without dysphagia, palpitation (93%, fever (91%, sweating and heat intolerance (80% and IBS like symptoms was 46%. Among 36 females, 16 patients (44.4% presented with oligomenorrhea/amenorrhea. Clinically palpable thyromegaly was present in 33 cases (73%, which was diffuse in 24 patients (73%, resting tachycardia in 35(78% while anaemia in 23(51%. A few cases (13/45 had raised blood pressure. Elevation of thyroid hormone was found in 44(97.7%, but in most cases it was mild; little reduction of TSH (0.1-0.3mIU was present in 43 (95%. Characteristically, low radio-iodine uptake (< 5% in 2 hours and 24 hours was found in 100% and thyroid scan revealed uniform uptake in all cases. ESR was raised in 100% cases and leucocytosis was present in 9(20%. Conclusion: It is concluded that subacute thyroiditis can be diagnosed on careful clinical examination. As it is a self limiting disease and does not usually need any anti-thyroid medication, subacute thyroiditis should be excluded in thyrotoxic patients before initiating anti-thyroid drugs. Key words: Subacute thyroiditis; clinical and biochemical profile DOI: 10.3329/bsmmuj.v3i2.7057BSMMU J 2010; 3(2: 82-85

  14. Epidemiology, diagnosis, and management of polycystic ovary syndrome

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    Sirmans SM

    2013-12-01

    Full Text Available Susan M Sirmans, Kristen A PateDepartment of Clinical and Administrative Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USAAbstract: Polycystic ovary syndrome (PCOS is a common heterogeneous endocrine disorder characterized by irregular menses, hyperandrogenism, and polycystic ovaries. The prevalence of PCOS varies depending on which criteria are used to make the diagnosis, but is as high as 15%–20% when the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria are used. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Risk factors for PCOS in adults includes type 1 diabetes, type 2 diabetes, and gestational diabetes. Insulin resistance affects 50%–70% of women with PCOS leading to a number of comorbidities including metabolic syndrome, hypertension, dyslipidemia, glucose intolerance, and diabetes. Studies show that women with PCOS are more likely to have increased coronary artery calcium scores and increased carotid intima-media thickness. Mental health disorders including depression, anxiety, bipolar disorder and binge eating disorder also occur more frequently in women with PCOS. Weight loss improves menstrual irregularities, symptoms of androgen excess, and infertility. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Spironolactone and finasteride are used to treat symptoms of androgen excess. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology. Recent data suggest that letrozole and metformin may play an important role in ovulation induction. Proper diagnosis and management of PCOS is essential to address patient concerns but also to prevent future metabolic, endocrine, psychiatric, and cardiovascular complications.Keywords: polycystic ovary syndrome

  15. Quality of life and marital sexual satisfaction in women with polycystic ovary syndrome.

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    Romana Pawlińska-Chmara

    2008-04-01

    Full Text Available Polycystic ovary syndrome affects 5-10% of women in the developed world, making it the most common endocrine disorder among women of reproductive age. The symptoms typically associated with polycystic ovary syndrome: amenorrhea, oligomenorrhea, hirsutism, obesity, subfertility, anovulation and acne can lead to a significant reduction in female life quality.The aim of the study was to evaluate the effect of polycystic ovary syndrome on quality of life and marital sexual satisfaction. Fifty women with polycystic ovary syndrome were qualified to the study as the research group. The control group consisted of fourty healthy women. A specific questionnaire was used as a research tool in this study. It included the socio-demographic part, polycystic ovary syndrome's symptomatology and validated scales: Polish version of Short Form-36 Health Survey (SF-36 and Index of Sexual Satisfaction (ISS. The mean age of researched women was 28.9+/-5.6 years, and in the control group - 30.5+/-5.3 years (p>0.05. Quality of life parameters for women with polycystic ovary syndrome were lower than for the controls in the aspect of: general health (p<0.01, limitations due to physical health (p<0.05, limitations due to emotional problems (p<0.001, social functioning (p<0.01, energy/fatigue (p<0.001 and emotional wellbeing (p<0.01. Studied women showed worse marital sexual functioning (p<0.05. Marital sexual dysfunctions were diagnosed in 28.6% of women with polycystic ovary syndrome and in 10.5% of healthy women (p<0.05. Polycystic ovary syndrome decreases quality of life and marital sexual functioning among women. A negative effect of hirsutism severity on general well-being and marital sexual life is also observed.

  16. Relationship between menstrual disorder and thyroid function —the analysis of 1 495 clinical case series%月经失调与甲状腺功能的联系——-对1495例临床系列病例的分析

    Institute of Scientific and Technical Information of China (English)

    孙宁; 林守清; 范燕燕; 李茜西; 吴丽萍

    2011-01-01

    To explore the relationship between menstrual disorder and thyroid function. Methods The clinical data of 1 495 patients enrolled in Endocrine Center of Gynaecology from January 4, 2006 to March 2, 2011 were analyzed. Patients filled in menstrual history- in details and the levels of thyroid stimulating hormone ( TSH ), free triiodothyronine ( FT3 ) and free thyroxine ( FT4 ) were measured. Results The incidence of abnormal thyroid function was 13.4% in patients with menstrual disorder and infertility. There was no statistical difference in menstruation disorder between patients of normal thyroid function and abnorrmal thyroid function( P = 0. 107 ), but the incidence of menstrual disorder in thyroid dysfunctional patients was 1.49 times that of normal thyroid functional cases. There was no statistical difference in menstruation disorder among different thyroid functional cases( P > 0.05 ). The incidence of menstrual disorder in subclinical hypothyroidism, hypothyroidism, subclinical hyperthyroidism and hyperthyroidism was 1.27, 3. 31, 1.40 and 2. 31 times respectively that of normal function. There was statistical difference in hypomenorrhea between patients with hyperthyroidism and normalthyroid function( P = 0.025 ). The incidence of abnormal uterine bleeding and oligomenorrhea in patients with subclinical hypothyroidism was 1.36 and 1.34 times respectively that of normal cases. The incidence of amenorrhea in hypothyroidism was 5.96 times that of normal thyroid functional cases. The incidence of hypomenorrhea in subclinical hyperthyroidism and hyperthyroidism was 3.42 and 10.3 times respectively. TSH, FT3 and FT4 levels did differ between patients with different menstrual disorder( P < 0. 001 ). Conclusion Hyperthyroidism or hypothyroidism can cause menstrual disturbances. Hypothyroidism is associated mainly with amenorrhea or oligomenorrhea, and subclinical hypothyroidism is associated mainly with abnormal uterine bleeding

  17. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.

    Science.gov (United States)

    Goodman, Neil F; Cobin, Rhoda H; Futterweit, Walter; Glueck, Jennifer S; Legro, Richard S; Carmina, Enrico

    2015-11-01

    , alopecia, and acne. Cycle length >35 days suggests chronic anovulation, but cycle length slightly longer than normal (32 to 35 days) or slightly irregular (32 to 35-36 days) needs assessment for ovulatory dysfunction. Ovulatory dysfunction is associated with increased prevalence of endometrial hyperplasia and endometrial cancer, in addition to infertility. In PCOS, hirsutism develops gradually and intensifies with weight gain. In the neoplastic virilizing states, hirsutism is of rapid onset, usually associated with clitoromegaly and oligomenorrhea. Girls with severe acne or acne resistant to oral and topical agents, including isotretinoin (Accutane), may have a 40% likelihood of developing PCOS. Hair loss patterns are variable in women with hyperandrogenemia, typically the vertex, crown or diffuse pattern, whereas women with more severe hyperandrogenemia may see bitemporal hair loss and loss of the frontal hairline. Oral contraceptives (OCPs) can effectively lower androgens and block the effect of androgens via suppression of ovarian androgen production and by increasing sex hormone-binding globulin. Physiologic doses of dexamethasone or prednisone can directly lower adrenal androgen output. Anti-androgens can be used to block the effects of androgen in the pilosebaceous unit or in the hair follicle. Anti-androgen therapy works through competitive antagonism of the androgen receptor (spironolactone, cyproterone acetate, flutamide) or inhibition of 5α-reductase (finasteride) to prevent the conversion of T to its more potent form, 5α-dihydrotestosterone. The choice of antiandrogen therapy is guided by symptoms. The diagnosis of PCOS in adolescents is particularly challenging given significant age and developmental issues in this group. Management of infertility in women with PCOS requires an understanding of the pathophysiology of anovulation as well as currently available treatments. Many features of PCOS, including acne, menstrual irregularities, and hyperinsulinemia

  18. Abnormal uterine bleeding: a study of menstrual patterns and histopathological patterns in perimenopausal females

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    Mahima Jain

    2015-02-01

    Full Text Available Background: In gynecology out-patient department there is a large group of patients especially in perimenopausal age group who present with various menstrual disorders. These can be as such caused due to various etiologies, which need to be investigated as line of management is thereupon decided. This study is undertaken to know the various abnormal uterine bleeding in perimenopausal women, and their histopathological pattern. Methods: This study is done at PDU medical college hospital, Rajkot, Gujarat which is a tertiary care centre. A retrospective analysis of 268 cases clinically presenting with abnormal uterine bleeding is done. They are further posted for dilatation and curettage after thorough investigation to rule out other pathologies. The endometrial samplings from the D and C material are collected and sent for histopathological assessment. The data is recorded and further analysed. Women between 40-55 years age group are included in this study. Women with diagnosed pelvic pathology, endocrinal cause and bleeding tendencies are excluded from the study. Results: In our study almost all menstrual disorders are found, commonest being menorrhagia in 42.16%. Other patterns reported are metrorrhagia in 3.35%, oligomenorrhea in 14.80%, polymenorrhea and polymenorrhagia in 5.22% and 5.59% cases. Post-menopausal bleeding is found in one case. The histopathological diagnoses reported in this study are proliferative and secretory phase in 26.49% and 19.77% respectively. Other endometrial hyperplasias reported are Swiss cheese in 1.86%, simple cystic hyperplasia in 12.31%, complex hyperplasia with or without atypia in 7% and 4.10% respectively. Malignancy is found in 2 cases. Conclusions: From this study it is well established that endometrial sampling from D and C material still remains the gold standard in diagnosis of various endometrial pathologies in low resource set-up. Thereby the further line of management can also be decided for a

  19. Prevalence of metabolic syndrome is higher among non-obese PCOS women with hyperandrogenism and menstrual irregularity in Korea.

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    Min-Ju Kim

    Full Text Available BACKGROUND: Hyperandrogenism (HA has been linked with several components of metabolic syndrome (MetS. Few studies in Asian women have evaluated the important risk factors for and prevalence of MetS according to PCOS subtype. In this study, we investigated differences in metabolic parameters and the prevalence of MetS in two major phenotypic subgroups of PCOS in Korea. Furthermore, we investigated the relationship between HA-associated parameters and MetS. MATERIALS AND METHODS: This cross-sectional observational study was conducted from May 2010 to December 2011 in Korea. A total of 837 females with PCOS, aged 15-40, were recruited from Departments of Obstetrics and Gynecology at 13 hospitals. Of those, 700 subjects with either polycystic ovaries (PCO+HA+oligomenorrhea/amenorrhea (O or PCO+O were eligible for this study. MetS was diagnosed according to the modified National Cholesterol Education Program (NCEP Adult Treatment Panel (ATP III guidelines and the International Diabetes Federation (IDF criteria. RESULTS: MetS was more prevalent in the PCO+HA+O group (19.7% than in the PCO+O (11.9% group. There were statistically significant trends for an increased risk of MetS in the PCO+HA+O group compared to the PCO+O group. After adjustment for age, the odds ratio of MetS was 2.192 in non-obese subjects with PCO+HA+O compared to those with PCO+O, whereas the risk of MetS was not different in obese patients. Multivariate logistic regression analysis showed that high free androgen index and low sex hormone-binding globulin were significantly associated with MetS in non-obese women with PCOS, with odds ratios of 4.234 (95% CI, 1.893-9.474 and 4.612 (95% CI, 1.978-10.750, respectively. However, no associations were detected between MetS and SHBG and FAI in obese PCOS subjects. CONCLUSIONS: Our results indicate that HA and its associated parameters (FAI and SHBG are significantly associated with MetS in non-obese PCOS subjects, whereas this association

  20. 47,Xxx in an adolescent with premature ovarian failure and autoimmune disease

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    Holland

    2000-05-01

    Background: Premature ovarian failure (POF) is often associated with autoimmune disorders. The 47,XXX karyotype has also been associated with POF and other genitourinary abnormalities. Following is a case of a 17 year old with immune thrombocytopenic purpura (ITP), POF, 47, XXX and a positive antinuclear antibody (ANA).Case Report: A 17 year old Caucasian female was referred to the Adolescent Health Clinic for evaluation of oligomenorrhea with secondary amenorrhea. Thelarche occurred at 12 years, and menarche at 13 years of age. Since then she had a total of five menstrual periods, spaced 1-15 months apart and lasting 3-5 days. Her last menstrual period was six months prior to presentation. Past medical history was significant for chronic ITP diagnosed seven months prior to presentation, when she developed easy bruising. She was treated with IV gamma globulin and had a moderate response, but relapsed several weeks later. She was started on oral prednisone and had a good response, but continued to relapse whenever steroids were tapered. She was therefore maintained on prednisone 10 mg QOD. There was no family history of irregular menses or autoimmune disease. Physical exam revealed a well-appearing, slightly Cushingoid 17 year old. Physical and cognitive development were age-appropriate. There were no stigmata of Turner Syndrome. The thyroid was normal. Breasts were Tanner 5; public hair was Tanner 3. The external genitalia were normal and appeared well-estrogenized. The remainder of the exam was unremarkable. Pelvic ultrasound demonstrated a normal uterus and ovaries. Laboratory evaluation was significant for elevated gonadotropins and nondetectable estradiol. ANA was positive at 1:320 with a speckled pattern. Blood counts, serologies, complement levels, and coagulation studies were otherwise normal. Cytogenetic studies revealed a 47,XXX karyotype. The patient was placed on an estrogen/norethindrone hormone replacement patch for premature ovarian failure. To date

  1. Modificações do estilo de vida na síndrome dos ovários policísticos: papel do exercício físico e importância da abordagem multidisciplinar Lifestyle modifications in the polycystic ovary syndrome: role of physical exercise and importance of multidisciplinary approach

    Directory of Open Access Journals (Sweden)

    George Dantas de Azevedo

    2008-05-01

    Full Text Available A síndrome dos ovários policísticos (SOP é uma desordem endócrina heterogênea com prevalência de 5 a 10% nas mulheres em idade reprodutiva. Na SOP, há associação com vários fatores de risco para desenvolvimento de doença cardiovascular, como resistência à insulina, dislipidemia, diabetes mellitus, hipertensão arterial, disfunção endotelial, obesidade central, síndrome metabólica e marcadores pró-inflamatórios crônicos. A prática de exercício físico, juntamente com orientação nutricional, tem sido recomendada como estratégia de primeira linha no tratamento da oligomenorréia, hirsutismo, infertilidade e obesidade nas mulheres com SOP. Nesse sentido, o objetivo da presente revisão foi analisar o papel específico do exercício e/ou atividade física nas modificações da composição corporal, sistema cardiovascular, níveis plasmáticos bioquímicos e hormonais e função reprodutiva de mulheres com SOP.The polycystic ovaries syndrome (POS is a heterogeneous endocrinal disorder prevalent in 5 to 10% of women in reproductive age. In POS, there is an association with risk factors linked to the development of cardiovascular disease such as insulin resistance, dislipidemia, diabetes mellitus, arterial hypertension, endothelial dysfunction, central obesity, metabolic syndrome and chronic pro-inflammatory markers. Physical exercise practice together with nutritional guidance have been recommended as first rate strategies in the treatment of oligomenorrhea, hirsutism, infertility and obesity in POS women. This way, the objective of the present review was to analyze the specific role played by exercise and/or physical activity in changes of the body shape, in biochemical and hormonal plasmatic levels, and in the POS women’s reproductive function.

  2. Randomized Trial Comparing the Effect of Endometrial Shedding With Medroxyprogesterone Acetate With Random Start of Clomiphene Citrate for Ovulation Induction in Oligo-ovulatory and Anovulatory Women.

    Science.gov (United States)

    Jones, Claire Ann; Garbedian, Kimberly; Dixon, Marjorie; Murphy, Kellie; Shapiro, Heather

    2016-05-01

    A recent retrospective study demonstrated that anovulatory infertile women who did not have a progestogen-induced withdrawal bleed before treatment with clomiphene citrate (CC) had higher pregnancy rates than women who had a withdrawal bleed and those who had spontaneous menstrual bleeding. We sought to assess endometrial thickness at the time of ovulation in oligo-ovulatory and anovulatory women who took CC with or without a preceding progestogen-induced withdrawal bleed. We conducted a pilot randomized trial in which women with infertility and oligomenorrhea or amenorrhea were randomly assigned to take either CC after a withdrawal bleed induced by medroxyprogesterone acetate (MPA) 10 mg daily for 10 days or to take CC without such a bleed. Study participants underwent cycle monitoring with ultrasound assessment of endometrial thickness at the time of LH surge or a human chorionic gonadotropin trigger, followed by timed intercourse or intrauterine insemination. Women who had not ovulated by cycle day 21 took an increased dose of CC, with or without an MPA-induced withdrawal bleed, to a maximum of three cycles. Participants and nurses were asked to complete a questionnaire about the study. There was no significant difference in endometrial thickness on the day of LH surge or human chorionic gonadotropin trigger between women who had a progestogen-induced withdrawal bleed and those who did not (P = 0.65). On average, the time to ovulation was 15 days longer in women who took MPA than in women who did not, but this difference was not statistically significant (P = 0.65). Satisfaction with the study was reported as high by both patients and nurses. In anovulatory or oligo-ovulatory women treated with CC, we found no significant difference in endometrial thickness whether or not the use of CC was preceded by a withdrawal bleed induced by MPA. Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gyn

  3. Correlation of MRI grading of bone stress injuries with clinical risk factors and return to play: a 5-year prospective study in collegiate track and field athletes.

    Science.gov (United States)

    Nattiv, Aurelia; Kennedy, Gannon; Barrack, Michelle T; Abdelkerim, Ashraf; Goolsby, Marci A; Arends, Julie C; Seeger, Leanne L

    2013-08-01

    Bone stress injuries are common in track and field athletes. Knowledge of risk factors and correlation of these to magnetic resonance imaging (MRI) grading could be helpful in determining recovery time. To examine the relationships between MRI grading of bone stress injuries with clinical risk factors and time to return to sport in collegiate track and field athletes. Cohort study (prognosis); Level of evidence, 2. A total of 211 male and female collegiate track and field and cross-country athletes were followed prospectively through their competitive seasons. All athletes had preparticipation history, physical examination, and anthropometric measurements obtained annually. An additional questionnaire was completed regarding nutritional behaviors, menstrual patterns, and prior injuries, as well as a 3-day diet record. Dual-energy X-ray absorptiometry was performed at baseline and each year of participation in the study. Athletes with clinical evidence of bone stress injuries had plain radiographs. If radiograph findings were negative, MRI was performed. Bone stress injuries were evaluated by 2 independent radiologists utilizing an MRI grading system. The MRI grading and risk factors were evaluated to identify predictors of time to return to sport. Thirty-four of the athletes (12 men, 22 women) sustained 61 bone stress injuries during the 5-year study period. The mean prospective assessment for participants was 2.7 years. In the multiple regression model, MRI grade and total-body bone mineral density (BMD) emerged as significant and independent predictors of time to return to sport. Specifically, the higher the MRI grade (P = .004) and lower the BMD (P = .030), the longer the recovery time. Location of the bone injury at predominantly trabecular sites of the femoral neck, pubic bone, and sacrum was also associated with a prolonged time to return to sport. Female athletes with oligomenorrhea and amenorrhea had bone stress injuries of higher MRI grades compared with

  4. 中医论治青春期肥胖型多囊卵巢综合征的疗效观察%Observation on therapeutic effect of traditional Chinese medicine on poly-cystic ovary syndrome in adolescents

    Institute of Scientific and Technical Information of China (English)

    牛彩琴; 张蜀; 雷枭; 张团笑

    2016-01-01

    目的:观察中医治疗青春期肥胖型多囊卵巢综合征的临床疗效。方法:选取经西医治疗后仍月经稀发或闭经患者共19例,给予口服苍附导痰汤配合针灸治疗,比较治疗前后的相关指标。结果:治疗3个月后,显效者10例(53%);有效者6例(32%);无效者3例(15%);总有效率为85%。结论:采用苍附导痰汤配合针灸治疗,可以重建正常的月经周期,有效降低雄激素水平,改善患者卵巢功能、胰岛素抵抗及临床症状,疗效较好,值得临床推广。%Objective:Observation on therapeutic effect of traditional Chinese medicine on polycystic ovary syndrome(PCOS)in Adolescents.Methods:19 cases of oligomenorrhea or amenorrhea after treatment of the western medicine,treated with Cang Fu Dao Tan decoction combined with acupuncture,then comparing the relevant data before and after treatment.Results:3 mouths after treatment,10 cases (53%)were markedly effective,6 cases (32%)were effective,and 3 cases (15%)were ineffective.The total effective rate was 85%.Conclusion:Treatment by acupuncture and moxibustion combined with Cang Fu Dao Tan decoction on the PCOS patients can re-build normal menstrual cycle,effectively reduce androgen levels,improve insulin resistance,ovarian function and clinical symptoms,and achieve good clinical results,so it is worthy of clinical applicaton.

  5. Advances of correlations between polycystic ovary syndrome and hyperhomocysteinemia%多囊卵巢综合征与高同型半胱氨酸血症相关性的研究进展

    Institute of Scientific and Technical Information of China (English)

    黄影; 王蔼明; 赵勇; 闫玲; 陈怡

    2013-01-01

    多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一组以内分泌代谢紊乱为主的综合征,临床表现主要包括月经稀发、排卵障碍、高雄激素血症以及卵巢多囊样改变.PCOS患者发生2型糖尿病、动脉硬化以及心血管疾病的风险增加,这主要和PCOS患者体内各种因素导致的胰岛素代谢紊乱和血管内皮系统损伤有关.同型半胱氨酸(homocysteine,HCY)作为血管内皮损伤的标志之一,是心血管疾病发病的独立危险因素,PCOS患者往往伴有高同型半胱氨酸血症(hyper-homocysteinemia,HHCY),这可能是导致PCOS患者心血管并发症的重要因素之一.目前PCOS患者体内HCY水平升高的机制尚未完全清楚,现就国内外这方面的研究进展做一综述.%Polycystic ovary syndrome (PCOS) is a common endocrine disorder which involves oligomenorrhea,ovulatory problems,hyperandrogenism,and polycystic ovary.The women with PCOS may have some remote complications such as type 2 diabetes mellitus,atherosclerosis,and cardiovascular disease.All these complications may partly attribute to hyperinsulinemia,insulin resistance,and dysfunction of endothelial system.Homocysteine (HCY),one of the most important marks reflecting endothelial dysfunction,is an independent risk factor of cardiovascular disease.And this may be an important cardiovascular disease risk factor for women with PCOS since these women are probably subjected to hyperhomocysteinemia (HHCY).So far it's not well known why women with PCOS are subjected to HHCY.This paper reviews the progress in this aspect of research,and here giving some possible suggestions.

  6. 多囊卵巢综合征遗传学研究新进展%Genetics of the Polycystic Ovary Syndrome

    Institute of Scientific and Technical Information of China (English)

    张春梅; 赵越(综述); 乔杰(审校)

    2013-01-01

    多囊卵巢综合征(PCOS)是一种复杂的生殖内分泌疾病,主要特征是月经稀发或闭经、高雄激素血症以及卵巢多囊样改变。遗传因素在PCOS发病中的重要作用已经得到证实,许多候选基因也被识别。目前发现的易感基因主要包括参与甾体激素生物合成、转运、作用和调节的相关基因,慢性炎症相关基因,胰岛素抵抗和转化生长因子β(TGF-β)通路相关基因等。全基因组关联研究(genome-wide association study,GWAS)为了解PCOS的发病机制提供了新方向。然而,由于PCOS患者基因和表型复杂,目前遗传学研究仍未得出明确结论。现对PCOS遗传学研究最新进展进行综述。%Polycystic ovary syndrome (PCOS) is a highly complex endocrine disorder,characterized by oligomenorrhea or amenorrhea,hyperandrogenemia,and polycystic ovaries. Genetic factors play important roles in PCOS etiology,and many candidate genes have been identified. Currently,the proposed susceptible genes include those involved in the regulation of steroid hormone biosynthesis and function,chronic inflammation,and insulin and TGF-β signaling pathway. The promising start of genome-wide association study(GWAS) provides new insights into the pathogenesis of PCOS. However,due to the genetic and phenotypic heterogeneity of PCOS,there is not a conclusion on the specific contributing genes of PCOS. In this review,we discussed the progress of the genetic analysis of PCOS.

  7. Diane-35 for adolescent polycystic ovary syndrome%达英-35治疗青春期多囊卵巢综合征疗效观察

    Institute of Scientific and Technical Information of China (English)

    李红; 晁晶; 陈思; 王绘

    2013-01-01

    目的 观察达英-35治疗青春期多囊卵巢综合征(PCOS)的近期疗效.方法 回顾我院接收的34例青春期多囊卵巢综合征患者的临床资料,并对达英-35治疗进行疗效分析.结果 患者经过治疗后,痤疮、闭经、月经稀发明显改善(P<0.05);治疗前、后多毛改善均不明显(P>0.05);治疗后生殖内分泌激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌激素(E2)、睾酮(T)]水平与治疗前相比均下降,效果明显(P<0.05).结论 用达英-35治疗青春期PCOS,在月经不规律、痤疮以及高雄激素体征等方面具有良好的疗效.%Objective To observe the short-term efficacy of Diane-35 in the treatment of adolescent patients with polycystic ovary syndrome.Methods The clinical data on 34 adolescent patients with polycystic ovary syndrome who had been treated in our hospital were reviewed.The efficacy of therapy with Diane-35 was analyzed.Results After treatment,symptoms of acne,amenorrhea,and oligomenorrhea were significantly improved (P<0.05) but symptom of hirsutism did not imporve obviously (P>0.05).The reproductive hormones (FSH,LH,E2,and T) were markedly decreased,as compared with the baselines (P<0.05).Conclusions Diane-35 has better short-term efficacy in the treatment of menstrual disorder,acne and high androgen level in adolescent patients with polycystic ovary syndrome.

  8. 达英-35及妈富隆治疗青春期多囊卵巢综合征的疗效%Efficacy of diane-35 and marvelon on adolescent polycystic ovary syndrome

    Institute of Scientific and Technical Information of China (English)

    谢桂珍; 邹晴燕

    2012-01-01

    Objective To observe the clinical efficacy of marvelon and diane-35 treatment for adolescent poly-cystic ovary syndrome. Methods 60 patients were randomly divided into two groups, group A received marvelon, group B received diane-35. After 3 cycles of treatment,we reexamined six kinds of female hormones and recorded patients' menstruation, hirsutism and acne conditions change. Patients were followed up for 3 months after treatment. Results After treatment, patients 'oligomenorrhea and acne of the two groups significantly improved ( P 0. 05 ) . There were 8 cases of recurrence of menstrual disorder in group A, and 9 cases in B group. Conclusion Marvelon and diane-35 have better effects on menstrual disorder caused by PCOS, marvelon is more appropriate for PCOS patients with high levels of LH / FSH, and diane-35 is better for patients with hyperandrogenism.%目的 观察妈富隆与达英-35治疗青春期多囊卵巢综合征(PCOS)的临床疗效.方法 将60例患者随机分为2组,A组给予妈富隆治疗,B组给予达英-35治疗,治疗3个周期后,复查女性激素6项,并记录患者月经、多毛及痤疮情况的变化,停药后随访3个月.结果 两组患者经过治疗后,月经稀发、痤疮明显改善(P<0.05);治疗前后多毛改善均不明显(P>0.05).停药后,A组月经失调复发者8例,B组9例.结论 妈富隆及达英-35对治疗青春期PCOS的月经失调均有良好疗效,妈富隆对LH/FSH值高的PCOS患者更合适,而达英-35对高雄激素血症的患者疗效更佳.

  9. Clinical features and detection of some hormones in the patients with polycystic ovary syndrome%多囊卵巢综合征临床特征和某些内分泌激素的检测

    Institute of Scientific and Technical Information of China (English)

    冯金鸽; 朱威; 申艳; 孟焱

    2012-01-01

    Objective: To compare the differences in dermatologic and metabolic features in polycystic ovary syndrome (PCOS) between the patients with obesity and those without obesity. Methods: A total of 116 cases of PCOS were divided into obese and non- obese groups according to the body mass index. Each of women underwent physical assessment including acne, hirsutism, seborrhea, androgenic alopecia and acanthosis nigricans. Correlation between the dermatologic features and metabolic parameters were analyzed with multivariate logistic regression models. Results: The prevalence rates of acne, hirsutism, seborrhea, androgenic alopecia and acanthosis nigricans were 5.2% vs40.5%, 29.3% vs37.0%, 14.7% vs22.4%, 14.7% vs24.1 and 1.7% vs4.3% in obesity and non - obesity groups, respectively. PCOS women with obesity had a higher risk of developing oligomenorrhea, a longer menses and a higher testosterone level. Conclusions: PCOS patients with obesity have more dermatologic disorders and ovulation dysfunction.%目的:比较肥胖和非肥胖性多囊卵巢综合征(PCOS)患者的皮肤病学特征和性激素水平的差异.方法:依据BMI标准将患者分为肥胖组(41例)和非肥胖组(75例),对各组中每个妇女进行体质评估,包括体型、痤疮、多毛症、皮脂溢出、雄激素性脱发和黑棘皮病.logistic多元回归分析皮肤病学特征与激素和代谢参数的相关性.结果: 肥胖和非肥胖组痤疮的发生率分别为5.2%和40.5%,多毛症为29.3%和37.0%,皮脂溢出为14.7%和22.4%,雄激素性脱发为14.7%和24.1%,黑棘皮病为1.7%和4.3%.与非肥胖组比较,肥胖组PCOS月经减少、经期延长,睾酮水平明显增高.结论:肥胖PCOS患者会出现更多的皮肤症状和排卵障碍.

  10. 二甲双胍辅助治疗多囊卵巢综合征不孕症患者90例临床分析%Clinical Analysis of 90 Patients with Polycystic Ovary Syndrome Treated with Metformin

    Institute of Scientific and Technical Information of China (English)

    肖杰

    2015-01-01

    目的:对二甲双胍辅助治疗多囊卵巢综合征不孕症患者临床效果进行分析。方法选取2013年7月—2015年8月在该院进行治疗的多囊卵巢综合征不孕症患者180例,随机分组,常规组患者90例,给予常规药物治疗;联合组患者90例,常规用药治疗基础上联合二甲双胍辅助治疗,对两组患者的治疗效果进行分析。结果对比治疗前面部痤疮、月经稀发、多毛症状差异无统计学意义(P>0.05)。治疗后联合组患者面部痤疮、月经稀发、多毛症状的比例明显低于常规组,差异有统计学意义(P0.05). After treatment, the proportion of facial acne, oligomenorrhea, hairy symptoms in combination group were significantly lower than the conventional group, differences has statistical signifi-cance(P<0.05). Testosterone, LH/FSH, fasting insulin, body mass index (BMI) of the two groups were significantly reduced, the difference was statistically significant (P<0.05). 42 cycles ovulation rate and successful pregnancy rate of the combina-tion group was significantly higher than the conventional group (P<0.05). All patients were successfully treated with medica-tion, and could be well tolerated treatment, there is no patients led to serious adverse consequences due to drug treatment. Conclusion Routine treatment combining with metformin in treatment of polycystic ovary syndrome could improve the clini-cal treatment effect, and the safety is higher, which can restore the fertility function of the patients, there is a high treatment value for patients with polycystic ovarian syndrome.

  11. Polycystic ovary syndrome in Salvador, Brazil: a prevalence study in primary healthcare

    Directory of Open Access Journals (Sweden)

    Gabrielli Ligia

    2012-11-01

    Full Text Available Abstract Background Polycystic ovary syndrome (PCOS is a common condition in women of reproductive age. It is characterized by hyperandrogenism, oligomenorrhea/amenorrhea and polycystic ovaries. It is associated with obesity, diabetes, dyslipidemia and cardiovascular disease. No studies have been conducted on the prevalence of PCOS in Brazilian or South American women. Few studies using the Rotterdam criteria have been published. The objective of the present study was to calculate the prevalence of PCOS at primary healthcare level in Salvador, Brazil based on these criteria. Methods This was a cross-sectional, two-phase study conducted in a probability sample of women of 18–45 years of age screened for cervical cancer in the primary healthcare network of the city of Salvador, Brazil. In the first phase, interviews were conducted, weight, height, waist circumference, blood pressure and random blood sugar levels were measured, and the presence of acne and hirsutism was investigated. Women with at least one diagnostic criterion were referred for the second phase, which consisted of specialist consultation, pelvic ultrasonography and hormone measurements for differential diagnosis and/or investigation of a second criterion. Results Of the 859 women interviewed, 88.5% were black and 58.7% had 11 years of schooling or less. A diagnosis of PCOS was excluded in 84.4%, undetermined in 7.1% and confirmed in 8.5% (95%CI: 6.80–10.56. There were no statistically significant differences between these three groups with respect to weight, body mass index, waist circumference, blood sugar levels or arterial blood pressure. Women with PCOS were younger (p = 0.00, taller (p = 0.04, had fewer children (p = 0.00, were better educated (p = 0.01, and had higher total testosterone levels (p = 0.01 and a higher LH/FSH ratio (p = 0.01. Conclusion According to the Rotterdam criteria, the prevalence of PCOS in women seeking primary

  12. Bone mineral density in female high school athletes: interactions of menstrual function and type of mechanical loading.

    Science.gov (United States)

    Nichols, Jeanne F; Rauh, Mitchell J; Barrack, Michelle T; Barkai, Hava-Shoshana

    2007-09-01

    During adolescence, skeletal integrity of girls is largely dependent on menstrual function and impact exercise, yet currently there is limited research regarding the interaction between menstrual status and type of mechanical loading associated with various high school sports. Our purpose was to examine associations of menstrual status, type of mechanical loading, and bone mineral density (BMD) in female high school athletes participating in high/odd impact or repetitive/non-impact sport. Participants were 161 female high school athletes (15.7+/-1.3 years; 165.3+/-6.9 cm; 59.4+/-8.7 kg) representing high/odd impact (n=93, including soccer, softball, volleyball, tennis, lacrosse, and track sprinters and jumpers), or repetitive/non-impact sports (n=68, including swimmers, cross-country and track distance runners who participated in events>or=800 m). Areal BMD was measured by DXA at the spine (L1-L4), proximal femur, and total body. Menstrual status was determined by self-report. Athletes with primary, secondary or oligomenorrhea were combined into a single group (oligo/amenorrheic) and compared to eumenorrheic athletes. Analysis of covariance (ANCOVA) with Bonferroni post hoc comparisons adjusted for age, BMI, and gynecological age were used to compare BMD of athletes in combined mechanical loading and menstrual status groups. We found significantly greater total hip (p=0.04) and trochanter (p=0.02) BMD (g cm(-2)) among eumenorrheic high/odd impact compared to eumenorrheic repetitive/non-impact athletes, and greater spine (p=0.01) and trochanter (p=0.04) BMD among high/odd impact eumenorrheic athletes compared to repetitive/non-impact oligo/amenorrheic athletes. Chi-squared analysis of BMD Z-scores adjusted for gynecological age showed a significantly greater percentage of repetitive/non-impact athletes (33.9%) compared to high/odd impact athletes (11.8%) with low spine BMD for their age (BMD Z-scoresports, and especially those with oligo/amenorrhea, may not be

  13. Clinical Risk Factors Analysis of Young Women with Early Endometrial Carcinoma%年轻女性早期子宫内膜癌临床高危因素分析

    Institute of Scientific and Technical Information of China (English)

    岑立微; 王莉

    2012-01-01

    of time were taken as control group. The retrospective analysis is conducted. Results: In the study group, 42% of the patients were obesity, 36% were infertility patients, 29% had oligomenorrhea; while in the control group, the ratios were 35% , 21 % and 8% , respectively. Except for obesity which had no statistically significant difference between the two groups, the other two aspects had statistically significant difference (P<0. 05). In the study group, 6% were with diabetes, 15% with high blood pressure, 6% with family history of cancer. 13% with polycystic ovary syndrome; while the ratios in the control group were 1%, 3%, 4%, 1% respectively. Among them, high blood pressure and polycystic ovary syndrome had statistically significant difference (P<0. 05). In the study group, the patients with the control of menstrual disorders accounted for 92%, compared with 32% in the contract group, the difference was statistically significant (P<0. 01). In the study group , 17% were with anemia, 40% with the womb substantial structure demonstrated by B ultrasonic, 52% with lining owe; while in the control group, the ratios were 1% ,93% and 6% , respectively, the differences were statistically significant (P<0. 01). Conclusions: For those women who have obesity, infertility, long - term oligomenorrhea menstrual disorders especially menorrhagia secondary anemia, high blood pressure, polycystic ovarian tumor, family history of cancer, and B ultrasonic echo owe all the tips lining, the follow - up blow or hysteroscopy inspection should be done as early as possible to detect EC earlier.

  14. 左炔诺孕酮宫内缓释系统治疗子宫内膜单纯性增生过长的研究%Study of Levonorgestrel Intrauterine System in the Treatment of Simple Endometrial Hyperplasia

    Institute of Scientific and Technical Information of China (English)

    奚滕滕; 崔秀娟; 孙燕娜

    2014-01-01

    oligomenorrhea,32 cases showed amenorrhea. Conclusions:Mirena is an efficient and simple treatment of simple endometrial hyperplasia. The influence of uterine arterie blood flow is its possible mechanism.

  15. Uso clínico do hormônio antimülleriano em ginecologia Clinical use for anti-mullerian hormone in gynecology

    Directory of Open Access Journals (Sweden)

    Gustavo Salata Romão

    2013-03-01

    iatrogenic gonadal injury in women with neoplasms who will be submitted to chemotherapy. It is also probable that AMH assessment will be included in protocols for the investigation of amenorrhea and oligomenorrhea, since AMH levels are increased in Polycystic Ovary Syndrome, reduced in premature ovarian failure and normal in other conditions such as hyperprolactinemia and hypogonadotropic hypogonadism. It is possible that AMH will be utilized in the future for the prediction of age at menopause and of reproductive prognosis, providing solid bases for pre-conceptive and contraceptive counseling.

  16. The etiology analysis of anovulation in reproductive period%育龄期无排卵的病因分析

    Institute of Scientific and Technical Information of China (English)

    王艳; 刘晓燕; 任慕兰

    2014-01-01

    Chronic anovulation in reproductive period is defined as a pathological state of the women with failure of the ovary to release ova, which is one of the most common causes of infertility. Anovulation is typically associated with amenorrhea or severe oligomenorrhea. The WHO classification divides women with anovulation into three major groups:WHO GroupⅠ,Ⅱ,Ⅲ. The most common causes of anovulation in reproductive period are hypothalamic dysfunction,pituitary disease,and ovarian dysfunction. Other glands dysfunction such as thyroid disease and adrenal dysfunction can lead to anovulation. The common ovarian causes of anovulation are congenital ovarian dysplasia,resistant ovarian syndrome(ROS),premature ovarian failure(POF),polycystic ovary syndrome(PCOS), and luteinized unruptured follicle syndrome( LUFS) ,of which POF and PCOS are the most common. Systemic diseases may affect ovulation,resulting a vicious cycle. The harmful substances in environment,especially the environmental hormone,have been confirmed to induce adverse reproductive effects in human beings. The pathogenesis of anovulation is complicated,accurate evaluation and identification of the cause should be the pivotal issue of effective treatment.%育龄期无排卵是指育龄女性长期无卵子成熟排出的病理状态,是女性不孕症的主要原因之一。育龄期无排卵多伴随着闭经或严重的月经过少。世界卫生组织将无排卵分为WHOⅠ~Ⅲ类。育龄期无排卵主要病因可分为下丘脑功能紊乱、垂体疾病、卵巢功能异常;其他内分泌腺体如甲状腺和肾上腺功能异常亦可能导致无排卵。卵巢功能异常所致的无排卵病因包括:先天性卵巢发育异常、卵巢抵抗综合征(resistant ovarian syndrome,ROS)、卵巢早衰(premature ovarian failure,POF)、多囊卵巢综合征(polycystic ovary syndrome,PCOS)、未破裂卵泡黄素化综合征( luteinized unruptured follicle syndrome,LUFS),最常见者为POF和PCOS。

  17. WISE 2005-2006: 60-days of Head-Down Bed Rest Increases the Incidence of Menstrual Cycle Disruption

    Science.gov (United States)

    Wade, Charles

    Objective: It has been suggested that acute bed rest of short duration (11 days) disrupts the menstrual cycle of healthy subjects. Furthermore, use of countermeasures such as heavy exercise or dietary manipulations may adversely effect the menstrual cycle. We hypothesized that bed rest of 60 days and the use of countermeasures would increase the incidence of disruption of the menstrual cycle (MC). Methods: Twenty-four healthy subjects with a mean age of 32±0.8 yr, body mass of 59±0.8 kg and MC lengths of 25-32 days were enrolled. Three months prior to the study subjects did not use hormonal birth control methods. Subjects were assigned to one of three groups (n=8 per group): control, exercise countermeasures, and dietary countermeasures. MC lengthening was defined as an increase in duration of 10 or more days. Analysis was performed accounting for the effects of bedrest as well as treatment group. Results: Effects of countermeasures were not significant in the present analysis. After the conclusion of the study, subjects were classified as either normal (N; n=16) or oligomenorrhea (O; n=8) as determined by MC length during the pre-bed rest (PB) and bed rest (BR) periods. During the control period prior to bed rest one subject (4%) had an increase MC length. During the control period the average MC length was 31±0.8 days with a leutinizing hormone (LH) surge 12±0.8 days prior to menses. The duration of menses was 4±0.4 days. During BR there was an increase to 33% (p¡0.05) in the number of subjects having MC lengthening. In these subjects the mean length was increased from 31±0.9 to 62±8.2 days (p¡0.05). There was no change in the period from the LH surge prior to the next menses, 11±0.8 days, or duration of menses, 4±0.2 days. Plasma LH, follicle stimulating hormone (FSH), prolacin (PRL), progesterone (PRG), estradiol (E2), dehydroepiandrosterone sulfate (DHEA-S), aldosterone (Aldo), testosterone (T) and cortisol (C) were measured during PB, BR, early

  18. Research progress in the relationship between polycystic ovary syndrome and reproductive function in obese women of child-bearing age and the therapies.%育龄期肥胖女性生殖功能与多囊卵巢综合征的关系及治疗的研究进展

    Institute of Scientific and Technical Information of China (English)

    季海波; 王卓然

    2015-01-01

    The relationship between obesity and fertility in women of childbearing age is very close, especial-ly abdominal obesity. Females with obesity often show oligomenorrhea, increased androgen levels and ovulation obsta-cle. In addition, studies show that obese people are more likely to have polycystic ovary syndrome, hyperandrogen-emia and metabolic abnormalities, compared with normal people. Disorder in sex hormones levels may be one of the key factors causing obesity of different types. Studies have confirmed that reducing of weight can correct sex hormone disorder, reduce androgen levels, establish regular menstrual cycle and restore ovulation, and thus improve the fertility of obese females. Previous experience applied drugs such as metformin to strengthen the function of ovary and pro-mote fertility by improving insulin resistance. In recent years, anti-obesity drugs are used for the treatment because of its functions of reducing fat and improving insulin resistance. This paper reviews the recent progress in polycystic ova-ry syndrome, fertility of obese women in child-bearing age, and related drug therapies.%肥胖与育龄期妇女生育能力的关系极为密切,尤其是以腹型肥胖者更加明显,此类人群多表现为月经稀发、雄激素水平增高及排卵障碍.此外,研究表明肥胖人群较正常人群更易发生多囊卵巢综合征、高雄激素血症和代谢功能异常.基础性激素水平紊乱可能是导致不同类型肥胖的关键因素之一,并且在大量研究中已证实降低体重可纠正性激素紊乱状态,降低雄激素水平,建立规律月经周期,恢复排卵,进而提高肥胖女性生育能力.以往针对此情况多采用二甲双胍等药物,通过改善胰岛素抵抗等途径增强卵巢功能,提供生育能力.近年来减肥药物因其具有减脂、改善胰岛素抵抗等作用,被用于此类患者的治疗,本文则对近年来多囊卵巢综合征与育龄期肥胖妇女生育能力及相关药物治疗进行综述.

  19. Clinical significance of screening macroprolactin in patients with hyperprolactinemia%高泌乳素血症患者筛查巨泌乳素的临床意义

    Institute of Scientific and Technical Information of China (English)

    方军; 潘恩云

    2011-01-01

    Objective To investigate the prevalence of macroprolactin ( M-PRL) in patients with hyperprolactinemia, and compare the clinical presentation and hormone levels between M-PRL and the true hyperprolactinemia. Methods Serum prolactin( PRL) , luleinizing hormone ( LH) , follicle-stimulating hormone ( FSH), estradiol(E2) and PRL after precipitation of M-PRL with polyethylene glycol (PEG) 6000 were measured by Architect i2000 immunology analyzer in 185 female patients with PRL>35 p.g/L. The clinical presentation was analyzed for retrospective review. Results The prevalence of M-PRL was 21% ,and the prevalences of oligomenorrhea, amenorrhea and galactorrhea in patients with true hyperprolactinemia (88% ) were significantly higher than those in M-PRL patients (47% ) ( P<0.05 ). The E2 and LH levels and LH / FSH ratio in M-PRL patients were significantly higher than those in patients with true hyperprolactinemia ( P<0. 05 ). Conclusions M-PRL is a common occurrence in patients with hyperprolactinemia,but the associated symptoms may partly be linked. The routine screening of all hyperprolactinemia sera for M-PRL is recommended.%目的 探讨高泌乳素血症患者中巨泌乳素(M-PRL)血症的检出率,比较M-PRL血症患者和高单体泌乳素血症患者的临床表现和激素水平.方法 使用Architect i2000免疫分析仪测定185例泌乳素(PRL)超过35μg/L的女性患者血清PRL、黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)和经聚乙二醇(PEG)6000沉淀后的PRL水平.记录临床症状用作回顾性分析.结果 M-PRL检出率为21%,月经过少、闭经和溢乳等症状在高单体泌乳素血症患者中的出现率(88%)高于M-PRL血症患者(47%)(P<0.05).M-PRL血症患者E2、LH水平和LH/FSH比值明显高于高单体泌乳素血症患者(P<0.05).结论 M-PRL在高泌乳素血症患者中经常发生,但仅部分患者有相关症状,建议所有高泌乳素血症患者筛查M-PRL.

  20. Irregularidades menstruales y de hormonas sexuales en mujeres que se les diagnosticó la diabetes tipo 1 antes de la menarquia o después de esta Menstruation disorders and sexual hormones in women diagnosed with type 1 diabetes before menarche or after it

    Directory of Open Access Journals (Sweden)

    Yaquelín González Ricardo

    2010-04-01

    determine the sexual hormones levels and to establish the influence of this entity on the menarche age. METHODS: a cross-sectional descriptive study was conducted in 74 women aged 15 and 35, all seen in the Diabetes Care Center of Ciudad de La Habana, Cuba, which were distributed in two groups: A and B, both with n= 37; A: diagnosed with diabetes before the menarche appearance and B; after it. We designed a questionnaire of general data and puberal and menstrual medical records; we determined the presence of fasting glycemia, glycosylated hemoglobin and sexual hormones; both groups were compared using the t Student and chi² tests. RESULTS: we achieved a high frequency of dysmenorrhea, menorrhhea and premenstrual tension, as well the loss of a correlation among some sexual hormones. Earlier presence of type 1 diabetes mellitus determined a greater age of menarche, lower levels of gonadotropins (LH and FSH and oligomenorrhea. CONCLUSIONS: type 1 diabetes mellitus diagnosed before menarche seems to interfere with maturation and subsequent function of female gonadal axis, which conditioned a greater frequency of dysmenorrhea and menstrual irregularities.

  1. 青春期多囊卵巢综合征肥胖与高雄激素临床表现的研究

    Institute of Scientific and Technical Information of China (English)

    刘畅; 邵洋; 黄建霞; 张治芬

    2013-01-01

      Objective To review the clinical features of adolescent patients with polycystic ovary syndrome (PCOS). Methods Eighty eight adolescent patients with polycystic ovary syndrome (PCOS group), including 40 cases with insulin resis-tance(IR) and 48 cases without insulin resistance(non-IR), and 87 healthy subjects(control group) were enrol ed in the study. The body mass index (BMI), homeostasis model of assessment for insulin resistence index (HOMA-IR) was measured in al groups. Results The prevalence of hirsutism, acne and obesity was significantly higher in PCOS group than those in control group (P<0.01), and that in IR group was also higher than in non-IR group (P<0.01). Menstrual disorders including dysmenorrhea and oligomenorrhea were common in PCOS group. Conclusion The adolescent PCOS patients have higher incidence of obesity, which may affect the insulin resistance, so weight control is the basic treatment for those patients.%  目的比较青春期多囊卵巢综合征(PCOS)患者与青春期健康对照人群、以及青春期PCOS患者中胰岛素抵抗(IR)与非IR的临床表现,以认识青春期PCOS的临床特征,为该疾病的早期诊断和治疗提供循证医学依据。方法青春期PCOS患者88例,健康对照组87例,并根据胰岛素抵抗稳态模型指数(HOMA-IR)将青春期PCOS患者分为IR组(40例)和非IR组(48例)。记录身高、体重、空腹血糖、空腹胰岛素、月经、多毛、痤疮等情况,并加以对照研究。结果青春期PCOS组月经均不规则,多毛、痤疮及肥胖发生率高,程度重。青春期PCOS IR组多毛、痤疮、高雄激素表现及肥胖发生率显著高于非IR组,肥胖PCOS患者IR发生率显著高于非肥胖PCOS。结论青春期PCOS患者肥胖发生率更高,肥胖放大了PCOS IR的程度和效应,控制体重为首选也是最基本的治疗方案。早期认识青春期PCOS的临床特征,有助于早期预测和

  2. Clinical analysis of 60 cases of adolescence polycystic ovarian syndrome%60例青春期多囊卵巢综合征临床资料分析

    Institute of Scientific and Technical Information of China (English)

    方洁; 吕淑兰; 李斌

    2012-01-01

    Objective To analyze the clinical and endocrine metabolism features of adolescence polycystic ovary syndrome ( PCOS ), so as to seek basis for early diagnosis. Methods Sixty cases of adolescence PCOS were selected. The general information was recorded, and hirsutism and acne were observed and scored. The blood samples were taken to detect the serum hormone levels, OGTT and IRT. The volume of ovary and the number of follicles were measured through intrarectal sonography. Results 100% of the adolescence PCOS suffered abnormal menstruation, 83. 3% of them had polycystic ovaries( PCO ), 53. 3% of them had central obesity, and 45. 0% of them had obesity including 81.5% accompanying with IR. Compared with patients with non-obesity, the age, BMI, WHR, OGTT2h and insulin levels at each time point were significantly different ( t = 2. 38 ~7. 36, all P <0.05 ). There were 68. 3% patients with IR, and their age, BMI, WHR, testosterone, serum glucose and insulin level at each time point were significantly different compared with patients with NIR ( t = 2. 14 ~ 5. 06, all P < 0. 05 ). There were 85. 0% of patients with hyperandrogenism. Compared with non-hyperandrogenism ones, there was significant difference in testosteone level ( t = 5. 45, P < 0. 05 ). Conclusion Most of adolescence PCOS accompany with menstrual disorders, PCO, central obesity, IR and hyperandrogenism. Menstrual disorder mainly embodies on oligomenorrhea, followed by secondary amenorrhea. Obese adolescence PCOS has a remarkable trend of suffering IR.%目的 分析青春期多囊卵巢综合征患者的临床和内分泌代谢特征,寻求其早期诊断的依据.方法 选择青春期多囊卵巢综合征患者60例,记录一般情况,观察有无多毛、痤疮并评分.抽血测定性激素、糖耐量试验及胰岛素释放试验.经直肠超声测量卵巢体积及卵泡数量.结果 100%的青春期多囊卵巢综合征患者有月经紊乱.83.3%有多囊性卵巢(PCO),53.3%有中心性肥胖,45.0%

  3. The correlation between glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome%育龄期多囊卵巢综合征患者的糖代谢异常和胰岛素抵抗

    Institute of Scientific and Technical Information of China (English)

    刘惠芬; 邱华娟; 陈美英; 纪燕琴

    2010-01-01

    Objective To investigate glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome(PCOS).Methods Seventy-eight cases of obese women witb PCOS,ninety cases of non-obese women with PCOS and one hundred cases of control group were reviewed regarding clinical features,endocrinal hormone,fasting glucose,fasting insulin,2 h postprandial glucose and 2 h postprandial insulin.Results The menstrual cycle,Hirsutism,acne,ultrasonography suggested ovarian increase,polycystic ovary change and infertility of adult women with PCOS were significantly different compared with the control group(P < 0.05).And the fasting glucose,2 h postprandial glucose,fasting insulin,2 h postprandial insulin of the obese group were also significantly higher compared with the control group (P < 0.05).Conclusion Attention would be paid to patients with early oligomenorrhea and high BMI for PCOS diagnosis.Adult women with PCOS especially the obese should check abnormal glucose metabolism and insulin resistance to determine whether actions should be taken to avoid the menace of long term complication.%目的 探讨育龄期多囊卵巢综合征(PCOS)患者的糖代谢异常和胰岛素抵抗.方法 选择育龄期PCOS患者168例,分为肥胖PCOS组78例和非肥胖PCOS组90例,正常对照组100例,对比临床表现及检测内分泌激素、空腹血糖、空腹胰岛素、服糖后2 h血糖及2 h胰岛素.结果 育龄期PCOS患者的月经周期、多毛、痤疮、B超提示卵巢增大、卵巢多囊性改变、有不孕史与对照组比较,差异均有显著性(P<0.05),育龄期PCOS组的血清LH、T与对照组比较,差异有显著性(P<0.05).育龄期肥胖P-COS组的空腹血糖、服糖后2 h血糖、空腹胰岛素、服糖后2 h胰岛素与对照组比较,差异均有显著性(P<0.05).结论 早期出现月经稀发、BMI升高的患者是否存在PCOS,值得重视.育龄期PCOS患者尤其肥胖型要高度重视糖代谢异常及胰岛素抵

  4. Weight loss treatment for patients with polycystic ovary syndrome%减肥治疗对肥胖多囊卵巢综合征患者的效果观察

    Institute of Scientific and Technical Information of China (English)

    黄建霞; 张治芬

    2013-01-01

    Objective To evaluate the effect of weight reduction in obese patients with polycystic ovary syndrome (PCOS). Methods Fifty obese patients with PCOS were recruited in the study from January 2009 to January 2011. The only treatment for patients was weight reduction for three months. The gonadal hormones, blood sugar, blood lipids, body weight, blood pressure, body mass index (BMI) and relevant clinical manifestations were assessed before and after three months of treatment. The men-strual changes and ovulation of patients were followed up for 6 months. Results After three months of weight loss treatment, the BMI was decreased by 2.18±1.99 kg/m2 on average. Among 43 patients who had acne, 39 improved;and of the 28 hairy pa-tients (F-G score 10.88 points), 14 were improved (F-G score 8.65 points). Al 50 patients with menstrual disorder (one had poly-menorrhea, one oligomenorrhea, others had amenorrhea) were fol owed up for 6 months, 26 of them had a restitution of regular cycles. After weight loss, LH, TT, FAI, SHBG, DHEAS, IGF1, IGFBP3, FBG, FINS, HOMA-IR, TC, HDL, APoB, LEP, ADPN im-proved significantly (P0.05). Conclusion Weight loss is an effective treatment for overweight PCOS patients, which can improve the serum level of gonadal hormones, blood sugar, blood lipids and clinical manifestations of PCOS.%  目的观察减肥治疗对肥胖型多囊卵巢综合征(PCOS)患者的疗效.方法选取2009年1月至2011年1月肥胖型PCOS患者50例,予减肥治疗3个月,观察体重、血压、BMI、痤疮、多毛等,关注月经变化和排卵情况6个月,检测患者治疗前后血清生殖内分泌激素及糖脂代谢指标.结果减肥3个月后,BMI平均下降2.18±1.99,43例痤疮患者,39例痤疮好转.50例患者均存在月经失调,26例恢复规律的排卵性月经.26例多毛患者,14例减轻(P0.05).结论减肥可以改善PCOS患者的临床症状及血清生殖激素及糖脂代谢指标,是肥胖PCOS患者的有效治疗方法,值得临床应用.

  5. Clinical features of polycystic ovary syndrome among adolescents and adults%青春期和育龄期多囊卵巢综合征的临床生化特征分析比较

    Institute of Scientific and Technical Information of China (English)

    王秋毅; 冯桂梅; 黄薇; 宋永; 张娜; 王秋石; 杨诗源; 肖丽; 周璐

    2013-01-01

    目的:探讨青春期多囊卵巢综合征(PCOS)患者的临床生化特征.方法:收集2010年8月至2012年10月四川大学华西二院妇产科门诊收治的126例青春期PCOS患者(青春期组)和368例育龄期PCOS患者(育龄期组),分析和比较两组患者的临床及生化指标.结果:(1)青春期组患者的初潮年龄(12.59±1.39)显著低于育龄期组(13.28±5.36)(P<0.05),但均在正常范围内;高雄症状的程度和发生率均显著高于育龄期组(P<0.05),体重指数(BMI)、腰围、腰臀比(WHR)和平均舒张压均显著低于育龄期组(P<0.05);(2)两组的平均血睾酮(T)、LH、FSH、LH/FSH及FINS、HOMA-IR、HDL无显著差异(P>0.05).青春期组的平均空腹血糖(FPG)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、TC/HDL及LDL/HDL均显著低于育龄期组(P<0.05);(3)青春期组的腰围≥80cm、收缩压≥130mmHg和FPG ≥5.6mmol/L的发生率显著低于育龄期组(P<0.05).结论:青春期PCOS患者具有PCOS特征性的高雄、代谢障碍问题,需加以关注,并及早治疗.%Objective:To explore the clinical and biochemical features of adolescents with polycystic ovary syndrome (PCOS).Methods:A retrospective analysis on adolescent and adult PCOS patients from Aug.2010 to Oct.2012 was conducted.Results:(1)The age at menarche,duration and age of oligomenorrhea,body mass index (BMI),waist circumference,waistto-hip ratio (WHR) and blood pressure were significantly lower in adolescent PCOS when compared with the adult patients (P<0.05).The Ferriman-Gallwey (F-G) score and acne score in adolescent PCOS were significantly higher than those of adult PCOS (P<0.05).(2) The fasting plasma glucose (FPG),total cholesterol (TC),triglyceride (TG),and low density lipoprotein (LDL) were significantly lower in adolescent PCOS.However,T,the fasting insulin (FINS)and homeostasis model assessment-insulin resistance index (HOMA-IR) showed no difference between them.(3)The index of metabolic

  6. Clinical Observation of Acupoint Catgut-embedding Therapy in Treating Obesity-type Polycystic Ovarian Syndrome%穴位埋线治疗肥胖型多囊卵巢综合征临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    朱巧玲; 林丽仪; 聂润球; 赵春梅

    2012-01-01

    Objective To observe the therapeutic effect of acupoint catgut-embedding therapy in treating obesity-type polycystic ovary syndrome ( PCOS). Methods Fourteen obesity-type PCOS patients were treated with acupoint catgut-embedding therapy for 3 months. Body mass index ( BMI) was examined, and the levels of luteinizing hormone (LH), testosterone (T), fasting blood glucose (FBG), fasting insulin, postprandial blood sugar, and 2-hour postprandial insulin as well as insulin resistance index ( HOMA-IR) were measured before and after treatment. The therapeutic effect was evaluated after comparison of the observation indexes. Results Before treatment, oligomenorrhea or amenorrhea occurred in all of the 14 patients. After treatment, menstrual onsel occurred within 45 days in 8 patients, and oral use of progesterone was for the rest patients to induce withdrawal uterine bleeding. Ten PCOS patients were complicated with infertility, but 2 patients had intrauterine gestation successfully on the 3rd or4th month of treatment. BMI , LH, T, fasting insulin, postprandial iasulin and HOMA-IK were decreased after treatment and the differences were significant ( P 0. 05). Conclusion Acuoint catgut-embedding therapy can effectively control the weight of obesisty-type PCOS patients, and can availably regulate the levels of endocrine hormones.%[目的]观察定位埋线治疗肥胖型多囊卵巢综合征(PCOS)患者的临床疗效.[方法]14例肥胖型PCOS患者均采用穴位埋线治疗3个月,治疗前后检测患者的体质量指数( BMI),检测黄体生成素(LH)、睾酮(T)、空腹血糖、空腹胰岛素、餐后2h血糖、餐后2h胰岛素水平及计算胰岛素抵抗指数(HOMA-IR),对各观察指标分别进行治疗前后比较.[结果](1) 14例患者治疗前均有月经稀发或闭经表现,经过穴位埋线治疗后有8例恢复周期在45 d内自行月经来潮,超过45 d仍未来经者予口服孕酮使之撤药性出血.其中合并不孕者10例,有2

  7. Relationship between thyroid function and menstrual disorder%女性月经失调患者甲状腺功能分析

    Institute of Scientific and Technical Information of China (English)

    刘聪; 李丽玮; 殷秀荣; 董丽霞; 韩研

    2013-01-01

    menstrual disorder was analyzed. Results: The levels of thyroid hormone and thyroid stimulating hormone in serum were not significantly different between pathological group and control group (P>0. 05). In the pathological group, the proportions of hypothyroidism, subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism were 10.42%, 4.69%, 6.25% and 3.62% respectively. In the control group, the proportions of hypothyroidism, subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism were 2.00%, 3.00%, 2.50% 3.00% respectively. The incidences of the thyroid diseases in the pathological group were higher than those in the control group, but there were no significant differences (P>0. 05) except the incidence of hypothyroidism (P<0. 05). The main type of menstrual disorders was oligomenorrhea in the patients with hypothyroidism and subclinical hypothyroidism, and hypomenorrhea in the patients with hyperthyroidism and subclinical hyperthyroidism. Conclusions: Thyroid dysfunction could cause menstrual disorders. The detection of thyroid function in the menstrual disorder women could offer some cues in diagnosis.

  8. Evaluation of common mental disorders in women with polycystic ovary syndrome and its relationship with body mass index Avaliação dos transtornos mentais comuns em mulheres com síndrome dos ovários policísticos e sua relação com o índice de massa corporal

    Directory of Open Access Journals (Sweden)

    Cristine Eliane Gomes Rodrigues

    2012-10-01

    Full Text Available PURPOSE: To evaluate the prevalence of common mental disorders in women diagnosed with polycystic ovary syndrome as compared with paired controls without this syndrome. METHODS: Cross-sectional study with a Control Group examining women between the ages of 18 and 30 who did not use antidepressants and who sought the Gynecology Service of the researched sites. For every woman diagnosed with the polycystic ovary syndrome, another with the same age, educational status and presence or absence of sexual partners was sought without this diagnosis. In total, 166 patients agreed to participate, consisting of 95 diagnosed with polycystic ovary syndrome and 71 in the Control Group. The diagnosis of polycystic ovary syndrome was made by the presence of two from three criteria: oligomenorrhea or amenorrhea, clinical or biochemical hyperandrogenism and polycystic ovaries on transvaginal ultrasound, following exclusion of patients with Cushing's syndrome, congenital adrenal hyperplasia, and androgen-secreting tumors. Weight and height were measured to calculate the body mass index. The Self-Reporting Questionnaire, which evaluated 20 items, was used as an indicator of common mental disorders. A χ² analysis stratified by the category of body mass index was used to compare the prevalence of common mental disorders, between the groups of women with and without the polycystic ovary syndrome. RESULTS: There were no significant differences in age, education, presence of sexual partners, ethnicity, socioeconomic status, use of psychiatric medication, and search for consultation in mental health between the studied groups. The prevalence of obese women with indications of common mental disorders was significantly higher in women with polycystic ovary syndrome than in the Control Group. In the group with healthy body mass index, the incidence of common mental disorders was statistically significant different between women with polycystic ovary syndrome and normal

  9. Sexual function in premenopausal women before and after renal transplantation%肾移植前后绝经期前成年女性性功能评估

    Institute of Scientific and Technical Information of China (English)

    于立新; 夏仁飞; 周敏捷

    2013-01-01

    目的 研究绝经期前成年女性肾移植前、后的性功能改变.方法 42例成年已婚女性、透析治疗超过6个月、肾移植术后肾功能恢复正常超过6个月的女性肾移植受者纳入研究.统计肾移植前后月经周期情况、检验患者手术前后性激素水平.采用女性性功能指数(FSFI)量表分别评估术前、术后患者的性功能.结果 肾移植前闭经、月经稀发、月经频发及月经正常的患者分别有18例(42.9%)、10例(23.8%)、5例(11.9%)、9例(21.4%),移植后分别为7例(16.7%)、5例(11.9%)、6例(14.3%)、24例(57.1%).肾移植后催乳素(PRL)、卵泡刺激素(FSH)及黄体生成素(LH)较肾移植术前明显降低,而雌二醇(E2)和孕酮(P)较术前升高(P<0.001).移植前19例(45.2%)、术后36例(85.7%)受者有性生活(P<0.001).肾移植前、后女性性功能障碍(FSD)的总发病率分别为90.5%、40.5%(P<0.001).肾移植前FSFI评分中性欲、性唤起、阴道润滑、性满意度、性高潮及性交痛领域的分值显著低于肾移植后(P<0.001).结论 肾移植术后肾功能恢复正常后成年女性受者的性功能能够明显改善.%Objective To study the changes in sexual function in premenopausal women after renal transplantation.Methods Forty-two married premenopausal women receiving dialysis therapy for at least 6 months with normal renal function for 6 months after renal transplantation were examined for hormonal profiles and menstrual cydes.The sexual functions of the patients were evaluated using Female Sexual Function Index (FSFI) before and 6 months after the transplantation.Results Before renal transplantation,amenorrhea,oligomenorrhea,polimenorrhea,and eumenorrhea were found in 18 cases (42.9%),10 cases (23.8%),5 cases (11.9%) and 9 cases (21.4%),as compared to 7 cases (16.7%),5 cases (11.9%),6 cases (14.3%) and 24 cases (57.1%) after the transplantation,respectively.Prolactin (PRL

  10. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME - PART 2.

    Science.gov (United States)

    Goodman, Neil F; Cobin, Rhoda H; Futterweit, Walter; Glueck, Jennifer S; Legro, Richard S; Carmina, Enrico

    2015-12-01

    Polycystic ovary syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists and the Androgen Excess Society aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2014. Insulin resistance is believed to play an intrinsic role in the pathogenesis of PCOS. The mechanism by which insulin resistance or insulin give rise to oligomenorrhea and hyperandrogenemia, however, is unclear. Hyperinsulinemic-euglycemic clamp studies have shown that both obese and lean women with PCOS have some degree of insulin resistance. Insulin resistance is implicated in the ovulatory dysfunction of PCOS by disrupting the hypothalamic-pituitary-ovarian axis. Given the association with insulin resistance, all women with PCOS require evaluation for the risk of metabolic syndrome (MetS) and its components, including type 2 diabetes, hypertension, hyperlipidemia, and the possible risk of clinical events, including acute myocardial infarction and stroke. Obese women with PCOS are at increased risk for MetS with impaired glucose tolerance (IGT; 31 to 35%) and type 2 diabetes mellitus (T2DM; 7.5 to 10%). Rates of progression from normal glucose tolerance to IGT, and in turn to T2DM, may be as high as 5 to 15% within 3 years. Data suggest the need for baseline oral glucose tolerance test every 1 to 2 years based on family history of T2DM as well as body mass index (BMI) and yearly in women with IGT. Compared with BMI- and age-matched controls, young, lean PCOS women have lower high-density lipoprotein (HDL) size, higher very-low-density lipoprotein particle number, higher low-density lipoprotein (LDL) particle number, and borderline lower LDL size. Statins have been shown to lower testosterone levels either alone or in combination with oral

  11. 青春期多囊卵巢综合征的临床特点分析%Clinical characteristics of polycystic ovary syndrome in adolescent girls

    Institute of Scientific and Technical Information of China (English)

    张琴; 庄宗恒; 陈藤

    2014-01-01

    目的:探讨青春期多囊卵巢综合征(PCOS)的临床特征。方法选择在我院妇科就诊的PCOS患者80例,其中青春期组34例,育龄期组46例。对比分析两组间的临床差别、性激素和血脂水平及胰岛素释放试验结果。结果(1)青春期组的发病年龄、病程和体重指数(BMI)均明显少于育龄期,P<0.05;但超重/肥胖的构成比、腰围和血压与育龄期组无统计学差异,P>0.05。(2)两组间的月经失调均主要表现为月经稀发,其次为闭经,均无统计学差别;青春期组的多毛和痤疮的评分及构成比均显著高于育龄期组, P<0.05。(3)青春期组血清睾酮(T),硫酸脱氢表雄酮(DHEAs)均显著高于育龄期组,P<0.01或P<0.05;性激素其余项无统计学差别P>0.05。(4)两组间空腹血糖、胰岛素和HOMA-IR均无统计学差别,P>0.05。但青春期组有胰岛素抵抗构成比和75g葡萄糖试验后,1h、2h和3h血糖和胰岛素显著低于育龄期组,P<0.05。青春期组血脂中仅LDL显著低于育龄期组,P<0.05,余项无统计学差别,P>0.05。结论与育龄期PCOS患者相比,青春期PCOS患者有更明显的高雄激素血症,较轻的肥胖、胰岛素抵抗和血脂异常。%Objective To explore the clinical features of polycystic ovary syndrome (PCOS) in adolescent girls. Methods Eighty patients with PCOS were selected and divided into adolescent (n=34) and adult (n=46) groups. Comparative analysis was made in the clinical differences, sex hormone and blood fat levels, and insulin releasing test results between the two groups. Results (1) The age of onset, course of disease, and body mass index (BMI) in the adolescent group were all lower than those in the adult group (P0.05). (2) The main manifestations of menstrual disorder in both groups were oligomenorrhea and amenorrhoea, but the differences between the two groups were not significant. The scores and

  12. 桂枝茯苓丸联合黄连素对多囊卵巢综合征伴胰岛素抵抗患者的影响%Influence of Guizhi Fuling Pill Combined with Berberine on Polycystic Ovary Syndrome with Insulin Resistance

    Institute of Scientific and Technical Information of China (English)

    陶柳; 庹安写; 刘茂艳

    2013-01-01

    level of total cholesterol (TC),triglycerides cholesterol (TG) in observe group were significantly decreased (P > 0.05).High-density lipoprotein cholesterol (HDL-C) in two groups increased significantly,especially degree of HDL-C in observation group was better than that in control grousignificantly (P <0.05).Luteinizing hormone (LH),LH/FSH,estriol (E2) in two groups decreased significantly and folliclestimulating hormone (FSH),E2 increased significantly (P < 0.05 or 0.01).especially The improvement degree of LH,LH/FSH,E2,oligomenorrhea,acne,ovarian volume in observation group was better than those in control group (P < 0.05).Ovulation was significantly higher than that in control group (P < 0.05).Conclusion:Guizhi Fuling pill combined with berberine can decrease insulin resistance,changing the fasting insulin and androgen levels in different ways,improving insulin sensitivity,restoring menstrual cycle,improving the pregnancy rate.

  13. Safety of gonadotropin releasing hormone analogue combined with Cy-clophosphamide in the treatment of patients with systemic lupus erythe-matosus%促性腺释放激素类似物联合环磷酰胺治疗系统性红斑狼疮的安全性

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    林琦; 王庆文; 黄倩羽; 蔡月明; 黄星涛; 魏蔚霞

    2015-01-01

    ovarian protective agent for CTX treatment in patients with SLE. Methods 24 female patients with SLE of childbearing age from March 2013 to December 2014 in Peking University Shenzhen Hospital were recruited and divided into the CTX+ GnRHa group (n=12) and CTX group (n=12) according to whether using GnRHa. While dual-energy X-ray absorp-tiometry was used to measure bone mineral density (BMD) of lumbar 1-4 (L1-L4 posterior-anterior position). SLE con-ditions between the two groups before and after the treatments, accumulation of CTX, BMD, as well as side effects after the treatments of two groups were compared. Results①SLE conditions:the clinical symptoms of patients in two groups were disappeared after treatments. There were significant differences in SLE disease activity index (SLEDAI) scores within the group before and after the treatments (t=23.534, 19.187;all P=0.000), while also significant differences in SLEDAI scores between the two groups after the treat-ments (t=3.425, P=0.002). ②The accumulation of CTX: the accumulation of CTX were (6.9±2.0), (7.0±1.5) g, respec-tively in the CTX + GnRHa and CTX group, with no statistically significant differences (t=0.217, P=0.830). ③BMD:there were no statistically significant differences in lumbar spine BMD before and after the treatments within two groups (t=0.126, 0.175;P=0.901, 0.863).④Side effects, perimenopausal symptoms and menstrual changes after the treatments:amenorrhoea appeared after using the second GnRHa in the CTX + GnRHa group, which accompanied by varying de-grees of low estrogen symptoms such as hot flash, sweating, sleep difficulties. While menstruation recovered and low es-trogen symptoms disappeared after stopping GnRHa. 7 cases appeared irregular menstruation, including 3 cases of menstrual dripping endless, 4 cases of oligomenorrhea, but without low estrogen symptoms in the CTX group. Conclu-sion Negative effect on SLE patients treated with GnRHa combined CTX, while GnRHa may protect the

  14. Frecuencia y características clínicas, hormonales y ultrasonográficas sugestivas de síndrome de ovarios poliquísticos en un grupo de mujeres con síndrome metabólico Frequency and clinical, hormonal and ultrasonographic characteristics suggestive of polycystic ovarian syndrome in a group of females with metabolic syndrome

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    Gisel Ovies Carballo

    2008-04-01

    -sectional study was undertaken among 90 females aged 18-45 with diagnosis of metabolic syndrome according to the modified criteria of the World Health Organization. They were interviewed and physically examined seeking clinical signs of polycystic ovarian syndrome (infertility, menstrual disorders, hirsutism, acne. Besides, the folliculostimulating hormone, the luteinizing hormone, prolactin and total testosterone were determined. A transvaginal gynecological ultrasound was performed between the third and the fifth day of the menstrual cycle, if they were menstruating or at any other moment, if they were not. Progesterone was also determined between the 21st and the 23rd day of the cycle, provided that they were menstruating. Patients were diagnosed polycystic ovarian syndrome when they had one or both clinical criteria, one or both hormonal criteria and the ultrasonographic criterion. RESULTS: 67.8 % of females presented oligomenorrhea; 81.1 %, hirsutism; 65.6 %, anovulatory progesterone values; and 55.6 % elevated testosterone. 63.3 % of the studied group had ultrasonographic signs suggestive of polycystic ovaries, and the most frequent sign was the presence of 10 or more follicles of ovarian periphery and stromal thickening. 51.1 % fulfilled the criteria for the diagnosis of polycystic ovarian syndrome. When we compared the behaviour of the group of females with polycystic ovarian syndrome and that without it, we observed that the mean of the insulin resistance index was higher in those that presented polycystic ovarian syndrome (7.5 vs. 6.5. As to the arterial tension, the systolic was significantly higher in the group with polycystosis (145.9 mmHg vs. 138.6 mmHg. As regards the body mass index, although there were not significantly statistical differences, the percentage of females with it ³ 30 kg/m² was higher in the patients with polycystic ovarian syndrome than in those without it (54.1 % vs. 45.9 %. CONCLUSIONS: the frequency of polycystic ovarian syndrome is high in