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Sample records for olav krt eve

  1. Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation.

    Science.gov (United States)

    Kuony, Alison; Michon, Frederic

    2017-01-01

    As an element of the lacrimal apparatus, the lacrimal gland (LG) produces the aqueous part of the tear film, which protects the eye surface. Therefore, a defective LG can lead to serious eyesight impairment. Up to now, little is known about LG morphogenesis and subsequent maturation. In this study, we delineated elements of the cellular and molecular events involved in LG formation by using three epithelial markers, namely aSMA, Krt14, and Krt19. While aSMA marked a restricted epithelial population of the terminal end buds (TEBs) in the forming LG, Krt14 was found in the whole embryonic LG epithelial basal cell layer. Interestingly, Krt19 specifically labeled the presumptive ductal domain and subsequently, the luminal cell layer. By combining these markers, the Fucci reporter mouse strain and genetic fate mapping of the Krt14 + population, we demonstrated that LG epithelium expansion is fuelled by a patterned cell proliferation, and to a lesser extent by epithelial reorganization and possible mesenchymal-to-epithelial transition. We pointed out that this epithelial reorganization, which is associated with apoptosis, regulated the lumen formation. Finally, we showed that the inhibition of Notch signaling prevented the ductal identity from setting, and led to a LG covered by ectopic TEBs. Taken together our results bring a deeper understanding on LG morphogenesis, epithelial domain identity, and organ expansion.

  2. Olav Marani vaikelude poeetikast / Tõnis Tatar

    Index Scriptorium Estoniae

    Tatar, Tõnis

    2010-01-01

    Maalikunstnik Olav Marani traditsioonilises laadis loodud vaikelude kunstilisest mudelist ja teostes väljenduvast esteetilisest ja eetilisest kvaliteedist. Ka natüürmordi kui žanri eripärast, eelkäijatest kunstiajaloos, Marani erinevusest neist ning tema kui religioosse kunstniku elufilosoofiast ja võtetest, mille abil ta seda on väljendanud

  3. Om Olav Tryggvessons enestående skib og enestående idrætsfærdighed

    DEFF Research Database (Denmark)

    Roesdahl, Else

    2008-01-01

    Om Olav Tryggvessons berømte skib Ormen Lange og de meget store skibe fra omkring år 1000 og begyndelsen af 1000-årene, som nu kendes arkæologisk. Og om kong Olavs legendariske færdigheder i sværdleg og at kunne løbe på et skibs årer...

  4. Keratin23 (KRT23 knockdown decreases proliferation and affects the DNA damage response of colon cancer cells.

    Directory of Open Access Journals (Sweden)

    Karin Birkenkamp-Demtröder

    Full Text Available Keratin 23 (KRT23 is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa. Array based methylation profiling of 40 colon samples showed that the promoter of KRT23 was methylated in normal colon mucosa, while hypomethylated in most adenocarcinomas. Promoter methylation correlated with absent expression, while increased KRT23 expression in tumor samples correlated with promoter hypomethylation, as confirmed by bisulfite sequencing. Demethylation induced KRT23 expression in vitro. Expression profiling of shRNA mediated stable KRT23 knockdown in colon cancer cell lines showed that KRT23 depletion affected molecules of the cell cycle and DNA replication, recombination and repair. In vitro analyses confirmed that KRT23 depletion significantly decreased the cellular proliferation of SW948 and LS1034 cells and markedly decreased the expression of genes involved in DNA damage response, mainly molecules of the double strand break repair homologous recombination pathway. KRT23 knockdown decreased the transcript and protein expression of key molecules as e.g. MRE11A, E2F1, RAD51 and BRCA1. Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT23 depleted cells compared to irradiated control cells.

  5. Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells

    DEFF Research Database (Denmark)

    Birkenkamp-Demtröder, Karin; Hahn, Stephan; Mansilla, Francisco

    2013-01-01

    correlated with absent expression, while increased KRT23 expression in tumor samples correlated with promoter hypomethylation, as confirmed by bisulfite sequencing. Demethylation induced KRT23 expression in vitro. Expression profiling of shRNA mediated stable KRT23 knockdown in colon cancer cell lines showed...... response, mainly molecules of the double strand break repair homologous recombination pathway. KRT23 knockdown decreased the transcript and protein expression of key molecules as e.g. MRE11A, E2F1, RAD51 and BRCA1. Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced......Keratin 23 (KRT23) is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa. Array based methylation profiling of 40 colon samples showed that the promoter of KRT23 was methylated in normal colon mucosa, while hypomethylated in most adenocarcinomas. Promoter methylation...

  6. The design of KRT digital system in Ling'ao Ⅱ

    International Nuclear Information System (INIS)

    Sun Yuanjun; Zhang Renyan; Zhao Weijun

    2013-01-01

    In the design of KRT system in Ling Ao Ⅱ, it requires the hardware composition shall be similar to that of Ling Ao Ⅰ. At the same time, the KRT system should be digitized and centralized. In order to realize the goal, the KRT system will be divided into the lower and upper parts. The local sensor at the lower part will transform the analog signal to digital signal in the local display unit; then the digital signals are sent to the upper part (cabinet) by RS-485; the cabinet collects the signals, saves and displays them in the server or operation workstation. or sends them to the DCS. On the other hand, the digital signals will be treated into analog or on/off signals in cabinet and transmitted to other systems. (authors)

  7. PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression

    International Nuclear Information System (INIS)

    Wu, Huijuan; Wang, Ke; Liu, Wenxin; Hao, Quan

    2014-01-01

    Highlights: • Overexpression of PTEN enhanced the sensitivity of C13K cells to cisplatin. • KRT10 is a downstream molecule of PTEN involved in the resistance-reversing effect. • Overexpression of KRT10 enhanced the chemosensitivity of C13K cells to cisplatin. - Abstract: Multi-drug resistance (MDR) is a common cause of the failure of chemotherapy in ovarian cancer. PTEN, a tumor suppressor gene, has been demonstrated to be able to reverse cisplatin-resistance in ovarian cancer cell line C13K. However, the downstream molecules of PTEN involved in the resistance-reversing effect have not been completely clarified. Therefore, we screened the downstream molecules of PTEN and studied their interactions in C13K ovarian cancer cells using a 3D culture model. Firstly, we constructed an ovarian cancer cell line stably expressing PTEN, C13K/PTEN. MTT assay showed that overexpression of PTEN enhanced the sensitivity of C13K cells to cisplatin, but not to paclitaxel. Then we examined the differently expressed proteins that interacted with PTEN in C13K/PTEN cells with or without cisplatin treatment by co-immunoprecipitation. KRT10 was identified as a differently expressed protein in cisplatin-treated C13K/PTEN cells. Further study confirmed that cisplatin could induce upregulation of KRT10 mRNA and protein in C13K/PTEN cells and there was a directly interaction between KRT10 and PTEN. Forced expression of KRT10 in C13K cells also enhanced cisplatin-induced proliferation inhibition and apoptosis of C13K cells. In addition, KRT10 siRNA blocked cisplatin-induced proliferation inhibition of C13K/PTEN cells. In conclusion, our data demonstrate that KRT10 is a downstream molecule of PTEN which improves cisplatin-resistance of ovarian cancer and forced KRT10 overexpression may also act as a therapeutic method for overcoming MDR in ovarian cancer

  8. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses.

    Science.gov (United States)

    Thomer, Annika; Gottschalk, Maren; Christmann, Anna; Naccache, Fanny; Jung, Klaus; Hewicker-Trautwein, Marion; Distl, Ottmar; Metzger, Julia

    2018-04-23

    Curly coat represents an extraordinary type of coat in horses, particularly seen in American Bashkir Curly Horses and Missouri Foxtrotters. In some horses with curly coat, a hypotrichosis of variable extent was observed, making the phenotype appear more complex. In our study, we aimed at investigating the genetic background of curly coat with and without hypotrichosis using high density bead chip genotype and next generation sequencing data. Genome-wide association analysis detected significant signals (p = 1.412 × 10 -05 -1.102 × 10 -08 ) on horse chromosome 11 at 22-35 Mb. In this significantly associated region, six missense variants were filtered out from whole-genome sequencing data of three curly coated horses of which two variants within KRT25 and SP6 could explain all hair phenotypes. Horses heterozygous or homozygous only for KRT25 variant showed curly coat and hypotrichosis, whereas horses with SP6 variant only, exhibited curly coat without hypotrichosis. Horses with mutant alleles in both variants developed curly hair and hypotrichosis. Thus, mutant KRT25 allele is masking SP6 allele effect, indicative for epistasis of KRT25 variant over SP6 variant. In summary, genetic variants in two different genes, KRT25 and SP6, are responsible for curly hair. All horses with KRT25 variant are additionally hypotrichotic due to the KRT25 epistatic effect on SP6.

  9. Ondskapens lidenskap og lidenskapens ondskap i Sigrid Undsets og Olav Duuns dikting

    DEFF Research Database (Denmark)

    Høystad, Ole Martin

    2007-01-01

     Artiklen diskuterer sammenhængen mellem kærlighed, (erotisk) lidenskab og ondskab i Sigrid Undsets og Olav Duuns digtning. Artiklen lavet på grundlag af foredrag - i anledning 100-årsjubilæet for to digteres debuter - på Norsk Litteraturfestival/Sigrid Undset-dagene på Lillehammer i 2007....

  10. Reactivation of larval keratin gene (krt62.L) in blastema epithelium during Xenopus froglet limb regeneration.

    Science.gov (United States)

    Satoh, Akira; Mitogawa, Kazumasa; Saito, Nanami; Suzuki, Miyuki; Suzuki, Ken-Ichi T; Ochi, Haruki; Makanae, Aki

    2017-12-15

    Limb regeneration is considered a form of limb redevelopment because of the molecular and morphological similarities. Forming a regeneration blastema is, in essence, creating a developing limb bud in an adult body. This reactivation of a developmental process in a mature body is worth studying. Xenopus laevis has a biphasic life cycle that involves distinct larval and adult stages. These distinct developmental stages are useful for investigating the reactivation of developmental processes in post-metamorphic frogs (froglets). In this study, we focused on the re-expression of a larval gene (krt62.L) during Xenopus froglet limb regeneration. Recently renamed krt62.L, this gene was known as the larval keratin (xlk) gene, which is specific to larval-tadpole stages. During limb regeneration in a froglet, krt62.L was re-expressed in a basal layer of blastema epithelium, where adult-specific keratin (Krt12.6.S) expression was also observable. Nerves produce important regulatory factors for amphibian limb regeneration, and also play a role in blastema formation and maintenance. The effect of nerve function on krt62.L expression could be seen in the maintenance of krt62.L expression, but not in its induction. When an epidermis-stripped limb bud was grafted in a froglet blastema, the grafted limb bud could reach the digit-forming stage. This suggests that krt62.L-positive froglet blastema epithelium is able to support the limb development process. These findings imply that the developmental process is locally reactivated in an postmetamorphic body during limb regeneration. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo.

    Science.gov (United States)

    Wu, H; Wang, K; Liu, W; Hao, Q

    2015-06-18

    Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-reversing effect of PTEN. However, whether overexpression of PTEN or KRT10 can improve the cisplatin resistance of ovarian cancer in vivo has not been investigated. Therefore, we investigated the effects of adenovirus-mediated PTEN or KRT10 overexpression on the cisplatin resistance of ovarian cancer in vivo. Recombinant adenoviruses carrying the gene for PTEN or KRT10 were constructed. The effects of overexpression of PTEN and KRT10 on cisplatin resistance of ovarian cancer cells were examined using the 3(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) and TdT-mediated dUTP nick-end labeling (TUNEL) assays in vitro. Subcutaneously transplanted nude mice, as a model of human ovarian cancer, were used to test the effects of PTEN and KRT10 on cisplatin resistance of ovarian cancer in vivo. The MTT assay showed that recombinant adenovirus-mediated overexpression of KRT10 and PTEN enhanced the proliferation inhibition effect of cisplatin on C13K cells. Recombinant adenovirus-mediated overexpression of KRT10 and PTEN also increased the cisplatin-induced apoptosis rate of C13K cells. Furthermore, recombinant adenovirus-mediated overexpression of KRT10 and PTEN enhanced the inhibitory effect of cisplatin on C13K xenograft tumor growth. Thus, recombinant adenovirus-mediated overexpression of KRT10 and PTEN may improve the cisplatin resistance of ovarian cancer in vitro and in vivo.

  12. In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval.

    Directory of Open Access Journals (Sweden)

    Heng Tao

    Full Text Available Efforts to develop effective therapeutic treatments for promoting fast wound healing after injury to the epidermis are hindered by a lack of understanding of the factors involved. Re-epithelialization is an essential step of wound healing involving the migration of epidermal keratinocytes over the wound site. Here, we examine genetic variants in the keratin-1 (KRT1 locus for association with migration rates of human epidermal keratinocytes (HEK isolated from different individuals. Although the role of intermediate filament genes, including KRT1, in wound activated keratinocytes is well established, this is the first study to examine if genetic variants in humans contribute to differences in the migration rates of these cells. Using an in vitro scratch wound assay we observe quantifiable variation in HEK migration rates in two independent sets of samples; 24 samples in the first set and 17 samples in the second set. We analyze genetic variants in the KRT1 interval and identify SNPs significantly associated with HEK migration rates in both samples sets. Additionally, we show in the first set of samples that the average migration rate of HEK cells homozygous for one common haplotype pattern in the KRT1 interval is significantly faster than that of HEK cells homozygous for a second common haplotype pattern. Our study demonstrates that genetic variants in the KRT1 interval contribute to quantifiable differences in the migration rates of keratinocytes isolated from different individuals. Furthermore we show that in vitro cell assays can successfully be used to deconstruct complex traits into simple biological model systems for genetic association studies.

  13. Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells

    Science.gov (United States)

    Kim, Kyeongseok; Yang, Gwang-Mo; Choi, Hye Yeon

    2018-01-01

    Cytokeratin 19 (KRT19) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. In our previous study, we revealed the role of KRT19 as signaling component which mediated Wnt/NOTCH crosstalk through NUMB transcription in breast cancer. Here, we investigated the function of KRT19 in cancer reprogramming and drug resistance in breast cancer cells. We found that expression of KRT19 was attenuated in several patients-derived breast cancer tissues and patients with a low expression of KRT19 were significantly correlated with poor prognosis in breast cancer patients. Consistently, highly aggressive and drug-resistant breast cancer patient-derived cancer stem cell-like cells (konkuk university-cancer stem cell-like cell (KU-CSLCs)) displayed higher expression of cancer stem cell (CSC) markers, including ALDH1, CXCR4, and CD133, but a much lower expression of KRT19 than that is seen in highly aggressive triple negative breast cancer MDA-MB231 cells. Moreover, we revealed that the knockdown of KRT19 in MDA-MB231 cells led to an enhancement of cancer properties, such as cell proliferation, sphere formation, migration, and drug resistance, while the overexpression of KRT19 in KU-CSLCs resulted in the significant attenuation of cancer properties. KRT19 regulated cancer stem cell reprogramming by modulating the expression of cancer stem cell markers (ALDH1, CXCR4, and CD133), as well as the phosphorylation of Src and GSK3β (Tyr216). Therefore, our data may imply that the modulation of KRT19 expression could be involved in cancer stem cell reprogramming and drug sensitivity, which might have clinical implications for cancer or cancer stem cell treatment. PMID:29747452

  14. Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells.

    Science.gov (United States)

    Saha, Subbroto Kumar; Kim, Kyeongseok; Yang, Gwang-Mo; Choi, Hye Yeon; Cho, Ssang-Goo

    2018-05-09

    Cytokeratin 19 ( KRT19 ) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. In our previous study, we revealed the role of KRT19 as signaling component which mediated Wnt/NOTCH crosstalk through NUMB transcription in breast cancer. Here, we investigated the function of KRT19 in cancer reprogramming and drug resistance in breast cancer cells. We found that expression of KRT19 was attenuated in several patients-derived breast cancer tissues and patients with a low expression of KRT19 were significantly correlated with poor prognosis in breast cancer patients. Consistently, highly aggressive and drug-resistant breast cancer patient-derived cancer stem cell-like cells (konkuk university-cancer stem cell-like cell (KU-CSLCs)) displayed higher expression of cancer stem cell (CSC) markers, including ALDH1 , CXCR4 , and CD133 , but a much lower expression of KRT19 than that is seen in highly aggressive triple negative breast cancer MDA-MB231 cells. Moreover, we revealed that the knockdown of KRT19 in MDA-MB231 cells led to an enhancement of cancer properties, such as cell proliferation, sphere formation, migration, and drug resistance, while the overexpression of KRT19 in KU-CSLCs resulted in the significant attenuation of cancer properties. KRT19 regulated cancer stem cell reprogramming by modulating the expression of cancer stem cell markers ( ALDH1 , CXCR4 , and CD133 ), as well as the phosphorylation of Src and GSK3β (Tyr216). Therefore, our data may imply that the modulation of KRT19 expression could be involved in cancer stem cell reprogramming and drug sensitivity, which might have clinical implications for cancer or cancer stem cell treatment.

  15. IL1RN and KRT13 Expression in Bladder Cancer: Association with Pathologic Characteristics and Smoking Status

    Directory of Open Access Journals (Sweden)

    Thomas S. Worst

    2014-01-01

    Full Text Available Purpose. To validate microarray data on cytokeratin 13 (KRT13 and interleukin-1 receptor antagonist (IL1RN expression in urothelial carcinoma of the urinary bladder (UCB and to correlate our findings with pathologic characteristics and tobacco smoking. Methods. UCB tissue samples (n=109 and control samples (n=14 were obtained from transurethral resection and radical cystectomy specimens. Immunohistochemical staining of KRT13 and IL1RN was performed and semiquantitative expression scores were assessed. Smoking status was evaluated using a standardized questionnaire. Expression scores were correlated with pathologic characteristics (tumor stage and grade and with smoking status. Results. Loss of KRT13 and IL1RN expression was observed in UCB tissue samples when compared to controls (P=0.007, P=0.008 in which KRT13 and IL1RN expression were high. IL1RN expression was significantly reduced in muscle-invasive tumors (P=0.003. In tissue samples of current smokers, a significant downregulation of IL1RN was found when compared to never smokers (P=0.013. Conclusion. Decreased expressions of KRT13 and IL1RN are common features of UCB and are associated with aggressive disease. Tobacco smoking may enhance the loss of IL1RN, indicating an overweight of proinflammatory mediators involved in UCB progression. Further validation of the influence of smoking on IL1RN expression is warranted.

  16. EVE and School

    CERN Multimedia

    EVE et École

    2017-01-01

    IMPORTANT DATES Enrolments 2017-2018 Enrolments for the school year 2017-2018 to the Nursery, the Kindergarten and the School will take place on 6, 7 and 8 March 2017 from 10 am to 1 pm at EVE and School. Registration forms will be available from Thursday 2nd March. More information on the website: http://nurseryschool.web.cern.ch/. Saturday 4 March 2017 Open day at EVE and School of CERN Staff Association Are you considering enrolling your child to the Children’s Day-Care Centre EVE and School of the CERN Staff Association? If you work at CERN, then this event is for you: come visit the school and meet the Management on Saturday 4 March 2017 from 10 to 12 am We look forward to welcoming you and will be delighted to present our structure, its projects and premises to you, and answer all of your questions. Sign up for one of the two sessions on Doodle via the link below before Wednesday 1st March 2017 : http://doodle.com/poll/gbrz683wuvixk8as

  17. Nådeløs omsorg. Kjærlighet, selvmord, kunst og overskridelse i Olav Duuns fiksjonsverden

    OpenAIRE

    Syéd, Grethe Fatima

    2012-01-01

    This dissertation discusses questions regarding love, suicide, art and transgression in the work of Olav Duun (1876-1939). The main theses are that there is an attitude worth searching for in Duun's work, and that this attitude expresses a caring which the concept of love is better suited to describe than terms taken from a philosophical ethics. Furthermore, I hold that the much discussed ethics in Duun's work is inseparable from the aesthetics, understood as having to do with beauty, art and...

  18. Overview of EVE - the event visualization environment of ROOT

    International Nuclear Information System (INIS)

    Tadel, Matevz

    2010-01-01

    EVE is a high-level visualization library using ROOT's data-processing, GUI and OpenGL interfaces. It is designed as a framework for object management offering hierarchical data organization, object interaction and visualization via GUI and OpenGL representations. Automatic creation of 2D projected views is also supported. On the other hand, it can serve as an event visualization toolkit satisfying most HEP requirements: visualization of geometry, simulated and reconstructed data such as hits, clusters, tracks and calorimeter information. Special classes are available for visualization of raw-data. Object-interaction layer allows for easy selection and highlighting of objects and their derived representations (projections) across several views (3D, Rho-Z, R-Phi). Object-specific tooltips are provided in both GUI and GL views. The visual-configuration layer of EVE is built around a data-base of template objects that can be applied to specific instances of visualization objects to ensure consistent object presentation. The data-base can be retrieved from a file, edited during the framework operation and stored to file. EVE prototype was developed within the ALICE collaboration and has been included into ROOT in December 2007. Since then all EVE components have reached maturity. EVE is used as the base of AliEve visualization framework in ALICE, Firework physics-oriented event-display in CMS, and as the visualization engine of FairRoot in FAIR.

  19. Overview of EVE - the event visualization environment of ROOT

    Energy Technology Data Exchange (ETDEWEB)

    Tadel, Matevz, E-mail: matevz.tadel@cern.c [CERN, CH-1211 Geneve 23 (Switzerland)

    2010-04-01

    EVE is a high-level visualization library using ROOT's data-processing, GUI and OpenGL interfaces. It is designed as a framework for object management offering hierarchical data organization, object interaction and visualization via GUI and OpenGL representations. Automatic creation of 2D projected views is also supported. On the other hand, it can serve as an event visualization toolkit satisfying most HEP requirements: visualization of geometry, simulated and reconstructed data such as hits, clusters, tracks and calorimeter information. Special classes are available for visualization of raw-data. Object-interaction layer allows for easy selection and highlighting of objects and their derived representations (projections) across several views (3D, Rho-Z, R-Phi). Object-specific tooltips are provided in both GUI and GL views. The visual-configuration layer of EVE is built around a data-base of template objects that can be applied to specific instances of visualization objects to ensure consistent object presentation. The data-base can be retrieved from a file, edited during the framework operation and stored to file. EVE prototype was developed within the ALICE collaboration and has been included into ROOT in December 2007. Since then all EVE components have reached maturity. EVE is used as the base of AliEve visualization framework in ALICE, Firework physics-oriented event-display in CMS, and as the visualization engine of FairRoot in FAIR.

  20. The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla.

    Science.gov (United States)

    Miura, Hirohito; Kusakabe, Yuko; Hashido, Kento; Hino, Akihiro; Ooki, Makoto; Harada, Shuitsu

    2014-09-19

    Tastants reach the tip of taste bud cells through taste pores which are openings in the epithelium. We found Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla (CV) where the epithelium is organized into taste pores. Sprr2a is a member of a small proline-rich protein family, which is suggested to be involved in the restitution/migration phase of epithelial wound healing. The expression of Sprr2a was restricted to the upper layer and largely segregated with Ptch1 expression that is restricted to the basal side of the epithelium around the taste buds. Denervation resulted in the gradual loss of Sprr2a-expressing cells over 10 days similarly to that of taste bud cells which is in contrast to the rapid loss of Ptch1 expression. We also found that denervation caused an increase of Keratin (Krt)13 expression around taste buds that corresponded with the disappearance of Sprr2a and Ptch1 expression. Taste buds were surrounded by Krt13-negative cells in the CV in control mice. However, at 6 days post-denervation, taste buds were tightly surrounded by Krt13-positive cells. During taste bud development, taste bud cells emerged together with Krt13-negtive cells, and Sprr2a expression was increased along with the progress of taste bud development. These results demonstrate that regional gene expression surrounding taste buds is associated with taste bud formation and controlled by the innervating taste nerve. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  1. gEVE: a genome-based endogenous viral element database provides comprehensive viral protein-coding sequences in mammalian genomes.

    Science.gov (United States)

    Nakagawa, So; Takahashi, Mahoko Ueda

    2016-01-01

    In mammals, approximately 10% of genome sequences correspond to endogenous viral elements (EVEs), which are derived from ancient viral infections of germ cells. Although most EVEs have been inactivated, some open reading frames (ORFs) of EVEs obtained functions in the hosts. However, EVE ORFs usually remain unannotated in the genomes, and no databases are available for EVE ORFs. To investigate the function and evolution of EVEs in mammalian genomes, we developed EVE ORF databases for 20 genomes of 19 mammalian species. A total of 736,771 non-overlapping EVE ORFs were identified and archived in a database named gEVE (http://geve.med.u-tokai.ac.jp). The gEVE database provides nucleotide and amino acid sequences, genomic loci and functional annotations of EVE ORFs for all 20 genomes. In analyzing RNA-seq data with the gEVE database, we successfully identified the expressed EVE genes, suggesting that the gEVE database facilitates studies of the genomic analyses of various mammalian species.Database URL: http://geve.med.u-tokai.ac.jp. © The Author(s) 2016. Published by Oxford University Press.

  2. 76 FR 81827 - Safety Zone; Sacramento New Years Eve Fireworks Display, Sacramento, CA

    Science.gov (United States)

    2011-12-29

    ... Zone; Sacramento New Years Eve Fireworks Display, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION... during the Sacramento New Years Eve Fireworks Display in the navigable waters of the Sacramento River... Sacramento New Years Eve Fireworks Display safety zones in the navigable waters of the Sacramento River near...

  3. EVE et École

    CERN Multimedia

    Staff Association

    2017-01-01

    Il reste des places disponibles ! La structure Espace de vie enfantine (EVE) et École de l’Association du personnel du CERN vous informe qu’il reste quelques places pour la rentrée scolaire 2017-2018 : à la crèche (2-3 ans) (accueil sur 2, 3 ou 5 jours) ; au jardin d’enfants (2-4 ans) (accueil à la matinée) ; en classe de 1ère primaire (1P) (4-5 ans). N’hésitez pas à rapidement nous contacter si vous êtes intéressés ; nous sommes à votre disposition pour répondre à toutes vos questions : Staff.Kindergarten@cern.ch. L’EVE et École de l’Association du personnel du CERN est ouverte non seulement aux enfants des personnels du CERN (MPE, MPA) mais également aux enfants des personnes ne travaillant pas sur le domaine du CERN. ...

  4. EVE et École

    CERN Multimedia

    Staff Association

    2017-01-01

    Une belle fête de fin d’année Le vendredi 23 juin, il y avait foule dans la structure EVE et École de l’Association du personnel du CERN! Et pour cause, au programme de cette fin d’après-midi : de nombreuses animations et jeux variés proposés pour le plaisir des enfants et des parents ; une fête en plein air, dans la cour de l’école et le jardin, avec des jeux, des stands, une buvette. Les frites et saucisses ont été préparées par l’équipe de l’EVE et École, qui portait des t-shirts fluo, en référence au thème de l’année: les couleurs. Plusieurs stands étaient proposés comme par exemple, un coin maquillage ; avec ces artistes maquilleurs, les enfants sont devenus lion, papillon ou coccinelle, l’histoire de quelques...

  5. Moekunstnik Eve Hanson: hindan häid traditsioone ja innovaatilisust / Eve Hanson ; intervjueerinud Tanel Veenre

    Index Scriptorium Estoniae

    Hanson, Eve

    2009-01-01

    Peadisainer Eve Hanson 1994. aastal loodud moemärgist Ivo Nikkolo. Näitus "Ivo Nikkolo 15 - julgus olla IN" Baltika kvartalis 29. nov.-ni. Eksponeeritud ka Ivo Nikkolo erikollektsioon "One in a hundred"

  6. EVE and School - Enrolments

    CERN Multimedia

    EVE et École

    2017-01-01

    IMPORTANT DATES Enrolments 2017-2018 Enrolments for the school year 2017-2018 to the Nursery, the Kindergarten and the School will take place on 6, 7 and 8 March 2017 from 10 am to 1 pm at EVE and School. Registration forms will be available from Thursday 2nd March. More information on the website: http://nurseryschool.web.cern.ch/.

  7. CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting.

    Science.gov (United States)

    Courtney, D G; Moore, J E; Atkinson, S D; Maurizi, E; Allen, E H A; Pedrioli, D M L; McLean, W H I; Nesbit, M A; Moore, C B T

    2016-01-01

    CRISPR/Cas9-based therapeutics hold the possibility for permanent treatment of genetic disease. The potency and specificity of this system has been used to target dominantly inherited conditions caused by heterozygous missense mutations through inclusion of the mutated base in the short-guide RNA (sgRNA) sequence. This research evaluates a novel approach for targeting heterozygous single-nucleotide polymorphisms (SNPs) using CRISPR/Cas9. We determined that a mutation within KRT12, which causes Meesmann's epithelial corneal dystrophy (MECD), leads to the occurrence of a novel protospacer adjacent motif (PAM). We designed an sgRNA complementary to the sequence adjacent to this SNP-derived PAM and evaluated its potency and allele specificity both in vitro and in vivo. This sgRNA was found to be highly effective at reducing the expression of mutant KRT12 mRNA and protein in vitro. To assess its activity in vivo we injected a combined Cas9/sgRNA expression construct into the corneal stroma of a humanized MECD mouse model. Sequence analysis of corneal genomic DNA revealed non-homologous end-joining repair resulting in frame-shifting deletions within the mutant KRT12 allele. This study is the first to demonstrate in vivo gene editing of a heterozygous disease-causing SNP that results in a novel PAM, further highlighting the potential for CRISPR/Cas9-based therapeutics.

  8. Genome-wide analysis of EgEVE_1, a transcriptionally active endogenous viral element associated to small RNAs in Eucalyptus genomes

    Directory of Open Access Journals (Sweden)

    Helena Sanches Marcon

    2017-02-01

    Full Text Available Abstract Endogenous viral elements (EVEs are the result of heritable horizontal gene transfer from viruses to hosts. In the last years, several EVE integration events were reported in plants by the exponential availability of sequenced genomes. Eucalyptus grandis is a forest tree species with a sequenced genome that is poorly studied in terms of evolution and mobile genetic elements composition. Here we report the characterization of E. grandis endogenous viral element 1 (EgEVE_1, a transcriptionally active EVE with a size of 5,664 bp. Phylogenetic analysis and genomic distribution demonstrated that EgEVE_1 is a newly described member of the Caulimoviridae family, distinct from the recently characterized plant Florendoviruses. Genomic distribution of EgEVE_1 and Florendovirus is also distinct. EgEVE_1 qPCR quantification in Eucalyptus urophylla suggests that this genome has more EgEVE_1 copies than E. grandis. EgEVE_1 transcriptional activity was demonstrated by RT-qPCR in five Eucalyptus species and one intrageneric hybrid. We also identified that Eucalyptus EVEs can generate small RNAs (sRNAs,that might be involved in de novo DNA methylation and virus resistance. Our data suggest that EVE families in Eucalyptus have distinct properties, and we provide the first comparative analysis of EVEs in Eucalyptus genomes.

  9. The First Report of KRT5 Mutation Underlying Acantholytic Dowling-Degos Disease with Mottled Hypopigmentation in an Indian Family

    Science.gov (United States)

    Verma, Shyam; Pasternack, Sandra M.; Rütten, Arno; Ruzicka, Thomas; Betz, Regina C.; Hanneken, Sandra

    2014-01-01

    Galli Galli disease (GGD) is the name given to a rare form of acantholytic Dowling-Degos disease. (DDD), the latter itself being a rare condition. We believe we are describing for the first time in Indian dermatologic literature a case of GGD in a family where 25 persons have DDD and have been able to document a KRT5 mutation in four members of the family. Whereas reticulate pigmentation is a hallmark of DDD there are rare reports of mottled pigmentation with multiple asymptomatic hypopigmented macules scattered diffusely along with the pigmentation. All the cases described here show a mottled pigmentation comprising hypo and hyperpigmented asymptomatic macules. After the clinical diagnosis was made by one of the authors (SV) in India, the German authors repeated histological examination and successfully demonstrated a heterozygous nonsense mutation, c.C10T (p.Gln4X), in exon 1 of the KRT5 gene, from various centers in Munich, Bonn, Dusseldorf and Friedrichschafen in Germany. PMID:25284854

  10. Sügismoes seguneb klassika vimkadega / Eve Rohtla

    Index Scriptorium Estoniae

    Rohtla, Eve, 1961-

    2003-01-01

    Ivo Nikkolo kaubamärki kandvat sügis-talvist kollektsiooni esitleti lioni'te naisteklubi salongiõhtul Viljandis. Disainer Eve Hanson kollektsiooni moeknihvidest. Ivo Nikkolo kollektsiooni disainib, toodab ja turustab osaühing Zik Zak

  11. EVE and School: Important announcement

    CERN Multimedia

    Staff Association

    2017-01-01

    Children’s Day-Care Centre (EVE) and School of the CERN Staff Association would like to inform you that there are still a few places available within the structure for the school year 2017–2018, in the: Nursery for 2, 3 or 5 days a week (2- to 3-year-olds); Kindergarten for mornings (2- to 4-year-olds); Primary 1 (1p) class in the School (4- to 5-year-olds). Please get in touch with us quickly if you are interested in any of the available places. We will gladly provide further information and answer any questions you may have: Staff.Kindergarten@cern.ch or (+41) 022 767 36 04 (mornings). EVE and School of the CERN Staff Association welcomes children of CERN Members of Personnel (MPE, MPA), as well as children whose parents do not work on CERN site. We would like to remind you that registrations are also open for the Summer Camp. The camp will run through the four weeks of July from 8.30 am to 5.30 pm with a weekly registration for 450 CHF, lunch included. For more information and regist...

  12. The p-EVES study design and methodology: a randomised controlled trial to compare portable electronic vision enhancement systems (p-EVES) to optical magnifiers for near vision activities in visual impairment.

    Science.gov (United States)

    Taylor, John; Bambrick, Rachel; Dutton, Michelle; Harper, Robert; Ryan, Barbara; Tudor-Edwards, Rhiannon; Waterman, Heather; Whitaker, Chris; Dickinson, Chris

    2014-09-01

    To describe the study design and methodology for the p-EVES study, a trial designed to determine the effectiveness, cost-effectiveness and acceptability of portable Electronic Vision Enhancement System (p-EVES) devices and conventional optical low vision aids (LVAs) for near tasks in people with low vision. The p-EVES study is a prospective two-arm randomised cross-over trial to test the hypothesis that, in comparison to optical LVAs, p-EVES can be: used for longer duration; used for a wider range of tasks than a single optical LVA and/or enable users to do tasks that they were not able to do with optical LVAs; allow faster performance of instrumental activities of daily living; and allow faster reading. A total of 100 adult participants with visual impairment are currently being recruited from Manchester Royal Eye Hospital and randomised into either Group 1 (receiving the two interventions A and B in the order AB), or Group 2 (receiving the two interventions in the order BA). Intervention A is a 2-month period with conventional optical LVAs and a p-EVES device, and intervention B is a 2-month period with conventional optical LVAs only. The study adopts a mixed methods approach encompassing a broad range of outcome measures. The results will be obtained from the following primary outcome measures: Manchester Low Vision Questionnaire, capturing device 'usage' data (which devices are used, number of times, for what purposes, and for how long) and the MNRead test, measuring threshold print size, critical print size, and acuity reserve in addition to reading speed at high (≈90%) contrast. Results will also be obtained from a series of secondary outcome measures which include: assessment of timed instrumental activities of daily living and a 'near vision' visual functioning questionnaire. A companion qualitative study will permit comparison of results on how, where, and under what circumstances, p-EVES devices and LVAs are used in daily life. A health economic

  13. Gender Ideology in The Diary Of Adam And Eve by Mark Twain

    Directory of Open Access Journals (Sweden)

    Paramita Ayuningtyas

    2011-04-01

    Full Text Available This article aims to show that behind the new version of Genesis by Mark Twain in his novel The Diary of Adam and Eve, there are some patriarchal principles that appear in it. It can be seen from the characterizations of Adam and Eve. By using some concepts from feminism and also focusing on the context of the novel, the analysis shows that patriarchal stereotypes about gender are applied in constructing the characters of Adam and Eve. Not only the content, but the form of the diary is also analyzed with the same method, and the same result is found. Therefore, it can be concluded that in spite of his progressiveness, Mark Twain still held patriarchal values in re-interpreting the tale of human creation.   

  14. Os instrumentos de regulação baseados no conhecimento: o caso do programme for international student assessment (PISA Knowledge-based regulation tools (KRT: the programme for international student assessment (PISA case

    Directory of Open Access Journals (Sweden)

    Estela Costa

    2009-12-01

    Full Text Available Este artigo inscreve-se na temática dos novos modos de regulação da educação, em particular nos instrumentos de políticas públicas. No quadro da instrumentação da acção pública, a atenção recai nos instrumentos de regulação baseados no conhecimento (Knowledge-based Regulation Tools [KRT]. Na verdade, a economia mundial fundamenta-se, cada vez mais, no conhecimento, o qual emerge como instrumento de política, regulando os actores sociais e legitimando a decisão política. O Programme for International Student Assessment (PISA, da Organização para Cooperação e Desenvolvimento Económico (OCDE, foi o instrumento escolhido como passível de configurar um KRT. O texto baseiase em seis estudos de caso, assentes em entrevistas e análise documental. Intentando na circulação e no uso do PISA, na Bélgica, Escócia, França, Hungria, Portugal e Roménia, procuramos demonstrar que o PISA se afirma como um KRT, provando a relação circular entre conhecimento e política, dado que, como instrumento de política, produz conhecimento e, como instrumento científico, produz política.This text focuses on the study of a KRT (Knowledgebased Regulation Tool, within the wider framework of the new modes of regulation in education, and use of instruments in public action. The world economy is gradually more knowledge-based. Knowledge emerges as a tool for policy-making and for regulating social actors, and legitimating the political decision-making. We choose the OECD's Program for International Student Assessment (PISA as an example of a KRT. The article is based on six case-studies, with interviews and document analysis. Our goal was to study the circulation and use of PISA, in Belgium, Scotland, France, Hungary, Portugal and Romania, trying to show that PISA is indeed a KRT, thus proving the circular relationship between knowledge and policy, because as a policy instrument it produces knowledge, and as a scientific tool it produces policy.

  15. EPO for the NASA SDO Extreme Ultraviolet Variability Experiment (EVE) Learning Suite for Educators

    Science.gov (United States)

    Kellagher, Emily; Scherrer, D. K.

    2013-07-01

    EVE Education and Public Outreach (EPO) promotes an understanding of the process of science and concepts within solar science and sun-earth connections. EVE EPO also features working scientists, current research and career awareness. One of the highlights for of this years projects is the digitization of solar lessons and the collaboration with the other instrument teams to develop new resources for students and educators. Digital lesson suite: EVE EPO has taken the best solar lessons and reworked then to make then more engaging, to reflect SDO data and made them SMARTboard compatible. We are creating a website that Students and teachers can access these lesson and use them online or download them. Project team collaboration: The SDO instruments (EVE, AIA and HMI) teams have created a comic book series for upper elementary and middle school students with the SDO mascot Camilla. These comics may be printed or read on mobile devices. Many teachers are looking for resources to use with their students via the Ipad so our collaboration helps supply teachers with a great resource that teachers about solar concepts and helps dispel solar misconceptions.Abstract (2,250 Maximum Characters): EVE Education and Public Outreach (EPO) promotes an understanding of the process of science and concepts within solar science and sun-earth connections. EVE EPO also features working scientists, current research and career awareness. One of the highlights for of this years projects is the digitization of solar lessons and the collaboration with the other instrument teams to develop new resources for students and educators. Digital lesson suite: EVE EPO has taken the best solar lessons and reworked then to make then more engaging, to reflect SDO data and made them SMARTboard compatible. We are creating a website that Students and teachers can access these lesson and use them online or download them. Project team collaboration: The SDO instruments (EVE, AIA and HMI) teams have created a

  16. Klaasikunstisügis Baltikumis / Eve Koha

    Index Scriptorium Estoniae

    Koha, Eve

    2002-01-01

    11. X-15. XI Kaunase raekojas M. K. Ciurlionise nim. rahvusliku kunsti muuseumi keraamika muuseumis rahvusvahelisel klaasikunsti biennaalil "Vitrum Balticum II" osalevad Eestist Eve Koha, Ivo Lill, Mare Saare. Albinas Elskusest, Mark Eckstrandist. 20. X-20. XI Riia vanalinna klaasigaleriis Laipu t. 6 eesti ja läti klaasikunstnike ühisnäitusel, kus tutvustatakse vanu klaasitehnikaid ja vanade klaasiahjude ehitust, osalevad Eestist Kati Kerstna, Merle Hiis

  17. The Lawless Frontier of Deep Space: Code as Law in EVE Online

    Directory of Open Access Journals (Sweden)

    Melissa de Zwart

    2014-03-01

    Full Text Available This article explores the concepts of player agency with respect to governance and regulation of online games. It considers the unique example of the Council of Stellar Management in EVE Online, and explores the multifaceted role performed by players involved in that Council. In particular, it considers the interaction between code, rules, contracts, and play with respect to EVE Online. This is used as a means to better understand the relations of power generated in game spaces.

  18. 77 FR 75556 - Safety Zone; Sacramento New Year's Eve Fireworks Display, Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-12-21

    ... Zone; Sacramento New Year's Eve Fireworks Display, Sacramento River, Sacramento, CA AGENCY: Coast Guard... safety zones during the Sacramento New Year's Eve Fireworks Display in the navigable waters of the Sacramento River on December 31, 2012 and January 1, 2013. The fireworks displays will occur from 9 p.m. to 9...

  19. An Innovative Aperture Cover Mechanism Used on SDO/EVE and MMS/SDP

    Science.gov (United States)

    Steg, Stephen; Vermeer, William; Tucker, Scott; Passe, Heather

    2014-01-01

    This paper describes an aperture cover mechanism that was successfully flown in four locations on SDO/EVE, and is awaiting launch in sixteen locations on MMS. This design uses a paraffin actuator and a latch that secures the cover closed and removes the actuator from the load path. This latch allows the assembly to operate both as a light weight contamination cover (SDO/EVE), and also as a high-strength sensor restraint mechanism (MMS/SDP). The paper provides design/analysis/test information about the mechanism.

  20. The Adam and Eve Robot Scientists for the Automated Discovery of Scientific Knowledge

    Science.gov (United States)

    King, Ross

    A Robot Scientist is a physically implemented robotic system that applies techniques from artificial intelligence to execute cycles of automated scientific experimentation. A Robot Scientist can automatically execute cycles of hypothesis formation, selection of efficient experiments to discriminate between hypotheses, execution of experiments using laboratory automation equipment, and analysis of results. The motivation for developing Robot Scientists is to better understand science, and to make scientific research more efficient. The Robot Scientist `Adam' was the first machine to autonomously discover scientific knowledge: both form and experimentally confirm novel hypotheses. Adam worked in the domain of yeast functional genomics. The Robot Scientist `Eve' was originally developed to automate early-stage drug development, with specific application to neglected tropical disease such as malaria, African sleeping sickness, etc. We are now adapting Eve to work with on cancer. We are also teaching Eve to autonomously extract information from the scientific literature.

  1. The chicken frizzle feather is due to an α-keratin (KRT75 mutation that causes a defective rachis.

    Directory of Open Access Journals (Sweden)

    Chen Siang Ng

    Full Text Available Feathers have complex forms and are an excellent model to study the development and evolution of morphologies. Existing chicken feather mutants are especially useful for identifying genetic determinants of feather formation. This study focused on the gene F, underlying the frizzle feather trait that has a characteristic curled feather rachis and barbs in domestic chickens. Our developmental biology studies identified defects in feather medulla formation, and physical studies revealed that the frizzle feather curls in a stepwise manner. The frizzle gene is transmitted in an autosomal incomplete dominant mode. A whole-genome linkage scan of five pedigrees with 2678 SNPs revealed association of the frizzle locus with a keratin gene-enriched region within the linkage group E22C19W28_E50C23. Sequence analyses of the keratin gene cluster identified a 69 bp in-frame deletion in a conserved region of KRT75, an α-keratin gene. Retroviral-mediated expression of the mutated F cDNA in the wild-type rectrix qualitatively changed the bending of the rachis with some features of frizzle feathers including irregular kinks, severe bending near their distal ends, and substantially higher variations among samples in comparison to normal feathers. These results confirmed KRT75 as the F gene. This study demonstrates the potential of our approach for identifying genetic determinants of feather forms.

  2. Percolation Model for the Existence of a Mitochondrial Eve

    CERN Document Server

    Neves, A G M

    2005-01-01

    We look at the process of inheritance of mitochondrial DNA as a percolation model on trees equivalent to the Galton-Watson process. The model is exactly solvable for its percolation threshold $p_c$ and percolation probability critical exponent. In the approximation of small percolation probability, and assuming limited progeny number, we are also able to find the maximum and minimum percolation probabilities over all probability distributions for the progeny number constrained to a given $p_c$. As a consequence, we can relate existence of a mitochondrial Eve to quantitative knowledge about demographic evolution of early mankind. In particular, we show that a mitochondrial Eve may exist even in an exponentially growing population, provided that the average number of children per individual is constrained to a small range depending on the probability $p$ that a newborn child is a female.

  3. Uus korter ja midagi veel / Eve Kaunis

    Index Scriptorium Estoniae

    Kaunis, Eve

    2008-01-01

    Uus Maa kinnisvarabüroo eluruumide konsultant Eve Kaunis ostjate eelistustest korterite valikul. Peamised müügiargumendid on soodne hind ja rohked lisaväärtused. Näiteks toodud 2-toaline korter (sisekujundus: Aet Piel, 71 m2) Põhja-Tallinnas Eugen Sachariase projekti järgi ehitatud majas ja 3-toaline korter (66,4 m2) Keilas 1980. aastatel ehitatud elamus

  4. Eve or Evolution? The Question of the Creation of Adam and Eve as the First Humans versus the Theory That Humankind Evolved Over The Course of Millions of Years

    Directory of Open Access Journals (Sweden)

    Eloise T. Choice

    2016-11-01

    Full Text Available Inherent in the Creation (“Intelligent Design” versus the Theory of Evolution (“natural selection” War, is the scientific belief in the millennia-long “evolution” of humankind, versus the Christian belief in the creation of the Biblical Adam and Eve circa 7,700 B.C. This article shows that there is no such thing as an “evolution” of Earth’s life forms. Over the course of millions of years, God created then, re-designed all Earth’s life forms in successive stages, which accounts for the non-linear progression of said forms and particularly of humanoids. Integrating Mitochondria DNA and archaeological evidence with Judeo-Christian and extra-Biblical texts, shows that after God created then re-designed pre-Adamic humans, He created the Biblical Adam and Eve circa 9,700 years ago during the Mesolithic Period as prototypes for present-day man. Moreover, archaeological evidence, plus Judeo-Christian and extra-Biblical texts suggest that Eve and Adam co-existed with Homo sapiens during the Mesolithic/Neolithic Periods.

  5. 78 FR 77359 - Eighth Coast Guard District Annual Safety Zones; New Year's Eve Celebration/City of Mobile...

    Science.gov (United States)

    2013-12-23

    ...-AA00 Eighth Coast Guard District Annual Safety Zones; New Year's Eve Celebration/City of Mobile; Mobile Channel; Mobile, AL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard will enforce the City of Mobile New Year's Eve Celebration safety zone in the Mobile Channel, Mobile, AL from...

  6. Eve and the Madonna in Victorian Art

    OpenAIRE

    Dungan, Bebhinn

    2012-01-01

    Full version unavailable due to 3rd party copyright restrictions. Full version unavailable due to 3rd party copyright restrictions. Full version unavailable due to 3rd party copyright restrictions. Full version unavailable due to 3rd party copyright restrictions. Full version unavailable due to 3rd party copyright restrictions. Abstract This study identifies and addresses representations of Eve and the Madonna exhibited at seven well-known London venues during the Victorian...

  7. Tantsija Eve Mutso jäi Londonis silma / Stuart Sweeney

    Index Scriptorium Estoniae

    Sweeney, Stuart

    2006-01-01

    Londonis andis märtsis külalisetendusi Šoti ballett, kus solistina esines juba aastaid Shoti balletis tantsiv eestlanna Eve Mutso. Ta astus üles Ashley Page'i balletis "Tuhkatriinu", samuti ühe juhtivsolistina George Balanchine'i "Episoodides" ja William Forsythe'i "Süidis artefaktist"

  8. Milton’s Pro-Feminist Presentation of Eve in Paradise Lost

    Directory of Open Access Journals (Sweden)

    Abdullah F. Al-Badarneh

    2014-07-01

    Full Text Available This paper absolves John Milton from any critical and feminist accusation of being anti-feminist in Paradise Lost. Such defense of Milton is based on the close reading and analysis of the passages that focus on Adam and Eve in the text. This study highlights Milton’s modern view of women as independent, free, and responsible. It also presents his iconoclasm in representing women as leaders and initiative takers when decision is to be taken. This study shows Milton reversing traditional gender roles through the relationship of Adam and Eve. In addition, one can find a modern emphasis on the principles of equality, democracy, dialogue, freedom, and free will available in the poem and designed in a way that serves Eve’s rights in comparison with Adam’s. Therefore, my voice in defending Milton joins the cohort of critics who believe of Milton’s wide perspective of pro-feminism and not a person of misogyny.

  9. Overview of EVE – the event visualization environment of ROOT

    CERN Document Server

    Tadel, M

    2010-01-01

    EVE is a high-level visualization library using ROOT's data-processing, GUI and OpenGL interfaces. It is designed as a framework for object management offering hierarchical data organization, object interaction and visualization via GUI and OpenGL representations. Automatic creation of 2D projected views is also supported. On the other hand, it can serve as an event visualization toolkit satisfying most HEP requirements: visualization of geometry, simulated and reconstructed data such as hits, clusters, tracks and calorimeter information. Special classes are available for visualization of raw-data. Object-interaction layer allows for easy selection and highlighting of objects and their derived representations (projections) across several views (3D, Rho-Z, R-Phi). Object-specific tooltips are provided in both GUI and GL views. The visual-configuration layer of EVE is built around a data-base of template objects that can be applied to specific instances of visualization objects to ensure consistent object prese...

  10. EVE: Explainable Vector Based Embedding Technique Using Wikipedia

    OpenAIRE

    Qureshi, M. Atif; Greene, Derek

    2017-01-01

    We present an unsupervised explainable word embedding technique, called EVE, which is built upon the structure of Wikipedia. The proposed model defines the dimensions of a semantic vector representing a word using human-readable labels, thereby it readily interpretable. Specifically, each vector is constructed using the Wikipedia category graph structure together with the Wikipedia article link structure. To test the effectiveness of the proposed word embedding model, we consider its usefulne...

  11. The effect of endoleak on intra-aneurysmal pressure after EVE for abdominal aortic aneurysm

    International Nuclear Information System (INIS)

    Huang Sheng; Jing Zaiping; Mei Zhijun; Lu Qingsheng; Zhao Jun; Zhang Suzhen; Zhao Xin; Cai Lili; Tang Jingdong; Xiong Jiang; Liao Mingfang

    2003-01-01

    Objective: To investigate the intra-aneurysmal pressure curve in the presence of endoleak after endovascular exclusion (EVE) for abdominal aortic aneurysm (AAA). Methods: Infrarenal aortic aneurysms were created with bovine jugular vein segments or patches. Then they were underwent incomplete endovascular exclusion of the aneurysm and formation of endoleaks. The pressures of blood flow outside the graft into the sac were measured. Results: The intrasac pressure was higher than systemic pressure in the presence of endoleak. After sealing the endoleak, pressure decreased significantly, and the pressure cure showed approximately linear. Conclusion: The change of intra-aneurysmal pressure curve reflected the load on aneurysmal wall after EVE, and can also help to determine the endoleak existence

  12. Extent, nature and hospital costs of fireworks-related injuries during the Wednesday Eve festival in Iran.

    Science.gov (United States)

    Alinia, Siros; Rezaei, Satar; Daroudi, Rajabali; Hadadi, Mashyaneh; Akbari Sari, Ali

    2013-01-01

    Fireworks are commonly used in local and national celebrations. The aim of this study is to explore the extent, nature and hospital costs of injuries related to the Persian Wednesday Eve festival in Iran. Data for injuries caused by fireworks during the 2009 Persian Wednesday Eve festival were collected from the national Ministry of Health database. Injuries were divided into nine groups and the average and total hospital costs were estimated for each group. The cost of care for patients with burns was estimated by reviewing a sample of 100 patients randomly selected from a large burn center in Tehran. Other costs were estimated by conducting semi structured interviews with expert managers at two large government hospitals. 1817 people were injured by fireworks during the 2009 Wednesday Eve festival. The most frequently injured sites were the hand (43.3%), eye (24.5%) and face (13.2%), and the most common types of injury were burns (39.9%), contusions/abrasions (24.6%) and lacerations (12.7%). The mean length of hospital stay was 8.15 days for patients with burns, 10.7 days for those with amputations, and 3 days for those with other types of injury. The total hospital cost of injuries was US$ 284 000 and the average cost per injury was US$ 156. The total hospital cost of patients with amputations was US$ 48 598. Most of the costs were related to burns (56.6%) followed by amputations (12.2%). Injuries related to the Persian Wednesday Eve festival are common and lead to extensive morbidity and medical costs. © 2013 KUMS, All rights reserved.

  13. Variable RNA expression from recently acquired, endogenous viral elements (EVE) of white spot syndrome virus (WSSV) in shrimp.

    Science.gov (United States)

    Utari, Heny Budi; Soowannayan, Chumporn; Flegel, Timothy W; Whityachumnarnkul, Boonsirm; Kruatrachue, Maleeya

    2017-11-01

    The viral accommodation hypothesis proposes that endogenous viral elements (EVE) from both RNA and DNA viruses are being continually integrated into the shrimp genome by natural host processes and that they can result in tolerance to viral infection by fortuitous production of antisense, immunospecific RNA (imRNA). Thus, we hypothesized that previously reported microarray results for the presence of white spot syndrome virus (WSSV) open reading frames (ORFs) formerly called 151, 366 and 427 in a domesticated giant tiger shrimp (Penaeus monodon) breeding stock might have represented expression from EVE, since the stock had shown uninterrupted freedom from white spot disease (WSD) for many generations. To test this hypothesis, 128 specimens from a current stock generation were confirmed for freedom from WSSV infection using two nested PCR detection methods. Subsequent nested-PCR testing revealed 33/128 specimens (26%) positive for at least one of the ORF at very high sequence identity (95-99%) to extant WSSV. Positive results for ORF 366 (now known to be a fragment of the WSSV capsid protein gene) dominated (28/33 = 84.8%), so 9 arbitrarily selected 366-positive specimens were tested by strand-specific, nested RT-PCR using DNase-treated RNA templates. This revealed variable RNA expression in individual shrimp including no RNA transcripts (n = 1), sense transcripts only (n = 1), antisense transcripts only (n = 2) or transcripts of both sense (n = 5). The latter 7 expression products indicated specimens producing putative imRNA. The variable types and numbers of the EVE and the variable RNA expression (including potential imRNA) support predictions of the viral accommodation hypothesis that EVE are randomly produced and expressed. Positive nested PCR test results for EVE of ORF 366 using DNA templates derived from shrimp sperm (germ cells), indicated that they were heritable. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. A Partnership between English Language Learners and a Team of Rocket Scientists: EPO for the NASA SDO Extreme Ultraviolet Variability Experiment (EVE)

    Science.gov (United States)

    Buhr, S. M.; McCaffrey, M. S.; Eparvier, F.; Murillo, M.

    2008-05-01

    Recent immigrant high school students were successfully engaged in learning about Sun-Earth connections through a partnership with the NASA Solar Dynamics Observatory Extreme Ultraviolet Variability Experiment (EVE) project. The students were enrolled in a pilot course as part of the Math, Engineering and Science Achievement (MESA) program. The English Language Learner (ELL) students doubled their achievement on a pre- and post- assessment on the content of the course. Students learned scientific content and vocabulary in English with support in Spanish, attended field trips, hosted scientist speakers, built antenna and deployed space weather monitors as part of the Stanford SOLAR project, and gave final presentations in English, showcasing their new computer skills. Teachers who taught the students in other courses noted gains in the students' willingness to use English in class and noted gains in math skills. The course has been broken into modules for use in shorter after-school environments, or for use by EVE scientists who are outside of the Boulder area. Video footage of "The Making of a Satellite", and "All About EVE" is completed for use in the kits. Other EVE EPO includes upcoming professional development for teachers and content workshops for journalists.

  15. Exhibition from 6 to 17 March 2017: EVE and School covered in colours.

    CERN Multimedia

    Staff Association

    2017-01-01

    The children of the EVE and School exhibited their artwork in the Main Building from 6 to 17 March. They worked on the theme of “colours” expressing themselves through various drawing, painting, collage and arts-and-crafts techniques. The result was a beautiful explosion of bright and shimmering colours!

  16. A Partnership between English Language Learners and a Team of Rocket Scientists: EPO for the NASA SDO Extreme-Ultraviolet Variability Experiment (EVE)

    Science.gov (United States)

    Buhr, S. M.; Eparvier, F.; McCaffrey, M.; Murillo, M.

    2007-12-01

    Recent immigrant high school students were successfully engaged in learning about Sun-Earth connections through a partnership with the NASA SDO Extreme-Ultraviolet Variability Experiment (EVE) project. The students were enrolled in a pilot course as part of the Math, Engineering and Science Achievement MESA) program. For many of the students, this was the only science option available to them due to language limitations. The English Language Learner (ELL) students doubled their achievement on a pre- and post-assessment on the content of the course. Students learned scientific content and vocabulary in English with support in Spanish, attended field trips, hosted scientist speakers, built and deployed space weather monitors as part of the Stanford SOLAR project, and gave final presentations in English, showcasing their new computer skills. Teachers who taught the students in other courses noted gains in the students' willingness to use English in class and noted gains in math skills. The MESA-EVE course won recognition as a Colorado MESA Program of Excellence and is being offered again in 2007-08. The course has been broken into modules for use in shorter after-school environments, or for use by EVE scientists who are outside of the Boulder area. Other EVE EPO includes professional development for teachers and content workshops for journalists.

  17. Project overview of OPTIMOS-EVE: the fibre-fed multi-object spectrograph for the E-ELT

    NARCIS (Netherlands)

    Navarro, R.; Chemla, F.; Bonifacio, P.; Flores, H.; Guinouard, I.; Huet, J.-M.; Puech, M.; Royer, F.; Pragt, J.H.; Wulterkens, G.; Sawyer, E.C.; Caldwell, M.E.; Tosh, I.A.J.; Whalley, M.S.; Woodhouse, G.F.W.; Spanò, P.; Di Marcantonio, P.; Andersen, M.I.; Dalton, G.B.; Kaper, L.; Hammer, F.

    2010-01-01

    OPTIMOS-EVE (OPTical Infrared Multi Object Spectrograph - Extreme Visual Explorer) is the fibre fed multi object spectrograph proposed for the European Extremely Large Telescope (E-ELT), planned to be operational in 2018 at Cerro Armazones (Chile). It is designed to provide a spectral resolution of

  18. The ADAM and EVE project: Heat transfer at ambient temperature

    International Nuclear Information System (INIS)

    Boltendahl, U.; Harth, R.

    1980-01-01

    In the nuclear research plant at Juelich a new heating system is at present being developed as part of the Nuclear Long-distance Heating Project. Helium is heated up in a high-temperature reactor. The heat chemically converts a gas mixture in a reformer plant (EVE). The gases 'charged' with energy can be transported through tubes over any distance required at ambient temperatures. In a methanisation plant (ADAM) the gases react with one another, releasing the energy in the form of heat which can be used for heating air or water. (orig.) [de

  19. Mille poolest on algav õppeaasta teile eriline? / Valmar Pantšenko, Martin Adamson, Maire Tamm, Eve Reisalu

    Index Scriptorium Estoniae

    2012-01-01

    Küsimusele vastavad: Tartu Täiskasvanute Gümnaasiumi abiturient Valmar Pantšenko, Eesti meister motokrossis klassis Quad 100 Martin Adamson, Tamsalu Gümnaasiumi õppealajuhataja Maire Tamm ja Ristiku põhikooli õpetaja-metoodik Eve Reisalu

  20. 78 FR 75248 - Safety Zone; Sacramento New Years Eve Fireworks Display, Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-12-11

    ... Zone; Sacramento New Years Eve Fireworks Display, Sacramento River, Sacramento, CA AGENCY: Coast Guard... safety zone in the navigable waters of the Sacramento River in Sacramento, CA on December 31, 2013 during... Sacramento River around the Tower Bridge in Sacramento, CA in approximate position 38[deg]34'49.98'' N, 121...

  1. 78 FR 75898 - Safety Zone; Sacramento New Years Eve Fireworks Display, Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-12-13

    ... Zone; Sacramento New Years Eve Fireworks Display, Sacramento River, Sacramento, CA AGENCY: Coast Guard... safety zone in the navigable waters of the Sacramento River in Sacramento, CA on December 31, 2013 during... Sacramento River around the Tower Bridge in Sacramento, CA in approximate position 38[deg]34'49.98'' N, 121...

  2. On the eve of Copenhagen: Obama and the environment

    International Nuclear Information System (INIS)

    Pereon, Y.M.

    2009-01-01

    The author proposes a rather detailed overview of the United States posture with respect to climate change challenges on the eve of the Copenhagen conference. First, he shows how the public opinion in the United States is ambivalent and changing. Then, he outlines that the arrival of President Obama resulted in an important change for the United States environmental policy: a new team was set up and the environment protection became a priority. The author then reports the Congressional process for this policy, first through the House of Representatives, and then the Senate. He highlights the differences between agendas of firms and of environment protection organisations, and between that of the Copenhagen conference and that of the US government

  3. 76 FR 78820 - Safety Zone; City of Beaufort's Tricentennial New Year's Eve Fireworks Display, Beaufort River...

    Science.gov (United States)

    2011-12-20

    ...-AA00 Safety Zone; City of Beaufort's Tricentennial New Year's Eve Fireworks Display, Beaufort River... establishing a temporary safety zone on the Beaufort River, in Beaufort, South Carolina, during the City of... Carolina. The fireworks will be launched from a barge, which will be located on the Beaufort River. The...

  4. Open Day at EVE and School of CERN Staff Association: an opportunity for many parents to discover the structure.

    CERN Multimedia

    Staff Association

    2017-01-01

    On Saturday, 4 March 2017, the Children’s Day-Care Centre EVE and School of CERN Staff Association opened its doors to allow interested parents to visit the structure. Staff Association - Carole Dargagnon presents the EVE and school during the open day. This event was a great success and brought together many families. The Open Day was held in two sessions (first session at 10 am and second at 11 am), each consisting in two parts: a general presentation of the structure by the Headmistress Carole Dargagnon, a tour of the installations with Marie-Luz Cavagna and Stéphanie Palluel, the administrative assistants. The management team was delighted to offer parents the opportunity to participate in this pleasant event, where everyone could express themselves, ask questions and find answers in a friendly atmosphere.

  5. Deaf-Accessibility for Spoonies: Lessons from Touring "Eve and Mary Are Having Coffee" While Chronically Ill

    Science.gov (United States)

    Barokka (Okka), Khairani

    2017-01-01

    This article presents lessons from touring a show on pain with limited resources and in chronic pain. In 2014, I toured solo deaf-accessible poetry/art show "Eve and Mary Are Having Coffee" in various forms in the UK, Austria, and India. As an Indonesian woman with then-extreme chronic pain and fatigue, herein are lessons learned from…

  6. [Eve Hele Sits. Mooni talurahva tähtpäevik ; Mooni metsauudistaja ; Mooni Eestimaa raamat ] / Helja Kirber ; suomennos Katariina Suurpalo

    Index Scriptorium Estoniae

    Kirber, Helja

    2014-01-01

    Tutvustus: Sits, Eve Hele. Mooni talurahva tähtpäevik. [Tallinn] : Argo, c2011; Mooni metsauudistaja : tähelepanekuid ja lugusid metsaelust. [Tallinn] : Argo, c2012; Mooni Eestimaa raamat. [Tallinn] : Argo, c2013

  7. Problems afoot for the CERN kindergarten (EVEE)?

    CERN Multimedia

    Staff Association

    2016-01-01

    You might have noticed that recently the Kindergarten changed names, it’s is now known under the name of EVEE which stands for ‘Espace de Vie Enfantine et École’ and currently welcomes 150 children between 4 months and 6 years of age. This establishment which is under the aegis of the Staff Association is governed by a committee composed of a mixture of the following: employers (from the Staff Association), employees, parents and the Headmistress who is an ex officio member (see Echo 238: http://staff-association.web.cern.ch/content/quoi-de-neuf-au-jardin-d%E2%80%99enfants). Great strides have been made in the past decade Over the previous decade in conjuction with the CERN Administration several new services have been proposed, including: the establishment of a canteen with a capacity of up to 60 children/day; the setting-up of a creche for infants ranging between 4 months and 3 years (approx 35 infants); the creation of a day-camp with the capacity to welcome up ...

  8. Kick off of the 2017-2018 school year at the EVE and School of the CERN Staff Association

    CERN Multimedia

    Staff Association

    2017-01-01

    The Children’s Day-Care Centre (“Espace de Vie Enfantine” - EVE) and School of the CERN Staff Association opened its doors once again to welcome the children, along with the teaching and administrative staff of the structure. The start of the school year was carried out gradually and in small groups to allow quality interaction between children, professionals and parents. At the EVE (Nursery and Kindergarten) and School, the children have the opportunity to thrive in a privileged environment, rich in cultural diversity, since the families (parents and children) come from many different nationalities. The teaching staff do their utmost to ensure that the children can become more autonomous and develop their social skills, all the while taking care of their well-being. This year, several new features are being introduced, for instance, first steps towards English language awareness. Indeed, the children will get to discover the English language in creative classes together with tr...

  9. Inspiratsiooni lätetel Amsterdamis : kuhu püüelda ja millest hoiduda... / Eve Koha

    Index Scriptorium Estoniae

    Koha, Eve

    2002-01-01

    Ülemaailmse klaasikunsti ühingu Glass Art Society 32. aastakonverentsist Amsterdamis 30. V-2. VI. Eestist osalesid Viivi-Ann Keerdo, Eve Koha, Kai Koppel, Eeva Käsper-Lennuk, Ivo Lill ja Tiina Sarapu. Näitusel "Young and Hot, European Emerging Artists" esindasid Eestit E. Käsper-Lennuk ja T. Sarapu. Elutööpreemiad ameeriklasele Fritz Dreisbachile (sünd. 1941) ja taanlasele Finn Lynggaardile (sünd. 1939)

  10. Polymer-based blood vessel models with micro-temperature sensors in EVE

    Science.gov (United States)

    Mizoshiri, Mizue; Ito, Yasuaki; Hayakawa, Takeshi; Maruyama, Hisataka; Sakurai, Junpei; Ikeda, Seiichi; Arai, Fumihito; Hata, Seiichi

    2017-04-01

    Cu-based micro-temperature sensors were directly fabricated on poly(dimethylsiloxane) (PDMS) blood vessel models in EVE using a combined process of spray coating and femtosecond laser reduction of CuO nanoparticles. CuO nanoparticle solution coated on a PDMS blood vessel model are thermally reduced and sintered by focused femtosecond laser pulses in atmosphere to write the sensors. After removing the non-irradiated CuO nanoparticles, Cu-based microtemperature sensors are formed. The sensors are thermistor-type ones whose temperature dependences of the resistance are used for measuring temperature inside the blood vessel model. This fabrication technique is useful for direct-writing of Cu-based microsensors and actuators on arbitrary nonplanar substrates.

  11. Paradise Lost: Difference Between Adam and Eve's Lament on Leaving Paradise - a Contrastive Analysis

    OpenAIRE

    Servín, Sara Torres

    2013-01-01

    The difference between Adam and Eve’s lament on leaving Paradise in Milton’s Paradise Lost is striking in its contrastive content and depth. This paper analyzes the difference that exists between the feelings and spiritual attitudes that Adam and Eve express on the occasion when they are informed by the angel Michael that they have to abandon the Garden of Eden. It is a comparison of their lament in order to understand the contrast of the two attitudes that Milton wove in the tapestry that Pa...

  12. Sequence analysis and heterologous expression of the wool cuticle-degrading enzyme encoding genes in Fusarium oxysporum 26-1.

    Science.gov (United States)

    Chaya, Etsushi; Suzuki, Tohru; Karita, Shuichi; Hanya, Akira; Yoshino-Yasuda, Shoko; Kitamoto, Noriyuki

    2014-06-01

    Two protease-like proteins, KrtA and KrtC, were identified in Fusarium oxysporum 26-1. Genes coding these proteins, krtA and krtC, were isolated and characterized. Recombinant KrtA (rKrtA) and KrtC (rKrtC) were successfully expressed in Aspergillus oryzae and secreted. The combination of rKrtA and rKrtC completely removed the cuticle of wool fibers. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  13. Resolving Differences in Absolute Irradiance Measurements Between the SOHO/CELIAS/SEM and the SDO/EVE.

    Science.gov (United States)

    Wieman, S R; Didkovsky, L V; Judge, D L

    The Solar EUV Monitor (SEM) onboard SOHO has measured absolute extreme ultraviolet (EUV) and soft X-ray solar irradiance nearly continuously since January 1996. The EUV Variability Experiment (EVE) on SDO, in operation since April of 2010, measures solar irradiance in a wide spectral range that encompasses the band passes (26 - 34 nm and 0.1 - 50 nm) measured by SOHO/SEM. However, throughout the mission overlap, irradiance values from these two instruments have differed by more than the combined stated uncertainties of the measurements. In an effort to identify the sources of these differences and eliminate them, we investigate in this work the effect of reprocessing the SEM data using a more accurate SEM response function (obtained from synchrotron measurements with a SEM sounding-rocket clone instrument taken after SOHO was already in orbit) and time-dependent, measured solar spectral distributions - i.e ., solar reference spectra that were unavailable prior to the launch of the SDO. We find that recalculating the SEM data with these improved parameters reduces mean differences with the EVE measurements from about 20 % to less than 5 % in the 26 - 34 nm band, and from about 35 % to about 15 % for irradiances in the 0.1 - 7 nm band extracted from the SEM 0.1 - 50 nm channel.

  14. Registrations for EVE and School and Summer Camp

    CERN Multimedia

    Staff Association

    2017-01-01

    In the wake of the Open Day, held on Saturday, 4 March 2017 (see Echo No. 264), EVE and School launched into an enrolment campaign on 6, 7 and 8 March. Once again, this year, we registered a great number of applications, and most of the groups are now full. The Nursery is already full, including the groups for babies (4 months to 1 year old), walkers (1 to 2 years old), and 2- to 3-year-olds. Regarding the Kindergarten, which welcomes 2- to 3 year-old children enrolled for mornings, as well as 3- to 4-year-olds enrolled either for mornings or for full days, there are still places available in the morning groups. Finally, the School for children aged 4 to 6 (Primary 1 and 2) enrolled for mornings or for full days, will be composed of three classes of around twenty children in 2017–2018 (one class of P1 and two classes of P2). All of these classes are currently full. If you are interested in a place in the morning groups of the Kindergarten (2- to 4-year-olds), please contact us to enroll your ...

  15. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth.

    Directory of Open Access Journals (Sweden)

    Rumana Khanom

    Full Text Available Keratin subtypes are selectively expressed depending on the cell type. They not only provide structural support, but regulate the metabolic processes and signaling pathways that control the growth of the epithelium. KRT17 (keratin 17 is induced in the regenerative epithelium and acts on diverse signaling pathways. Here, we demonstrate that KRT17 is invariably and permanently induced in oral squamous cell carcinoma (OSCC, as revealed by immunohistochemistry and cDNA microarray analysis. Two representative OSCC cell lines; KRT17-weakly expressing Ca9-22 and KRT17-highly expressing HSC3 were used to establish KRT17-overexpressing Ca9-22 and KRT17-knockdown HSC3 cells. Analysis of these cells revealed that KRT17 promoted cell proliferation and migration by stimulating the Akt/mTOR pathway. KRT17 also upregulated the expression of SLC2A1 (solute carrier family 2 member 1/Glut1 and glucose uptake. To further investigate the effect of KRT17 on tumorigenesis, KRT17-knockout HSC3 cells were established and were transplanted to the cephalic skin of nude mice. The tumors that developed from KRT17-knockout HSC3 cells had a lower Ki-67 labeling index and were significantly smaller compared to the controls. These results indicate that KRT17 stimulates the Akt/mTOR pathway and glucose uptake, thereby facilitating tumor growth. We could not confirm the relationship between KRT17 and SFN (stratifin in the cells examined in this study. However, our study reinforces the concept that the cellular properties of cancer are regulated by a series of molecules similar to those found in wound healing. In OSCC, KRT17 acts as a pathogenic keratin that facilitates tumor growth through the stimulation of multiple signaling pathways, highlighting the importance of KRT17 as a multifunctional promoter of tumorigenesis.

  16. Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.

    Science.gov (United States)

    Haybaeck, Johannes; Stumptner, Cornelia; Thueringer, Andrea; Kolbe, Thomas; Magin, Thomas M; Hesse, Michael; Fickert, Peter; Tsybrovskyy, Oleksiy; Müller, Heimo; Trauner, Michael; Zatloukal, Kurt; Denk, Helmut

    2012-06-01

    Keratin 8 (K8) and keratin 18 (K18) form the major hepatocyte cytoskeleton. We investigated the impact of genetic loss of either K8 or K18 on liver homeostasis under toxic stress with the hypothesis that K8 and K18 exert different functions. krt8⁻/⁻ and krt18⁻/⁻ mice crossed into the same 129-ola genetic background were treated by acute and chronic administration of 3,5-diethoxy-carbonyl-1,4-dihydrocollidine (DDC). In acutely DDC-intoxicated mice, macrovesicular steatosis was more pronounced in krt8⁻/⁻ and krt18⁻/⁻ compared with wild-type (wt) animals. Mallory-Denk bodies (MDBs) appeared in krt18⁻/⁻ mice already at an early stage of intoxication in contrast to krt8⁻/⁻ mice that did not display MDB formation when fed with DDC. Keratin-deficient mice displayed significantly lower numbers of apoptotic hepatocytes than wt animals. krt8⁻/⁻, krt18⁻/⁻ and control mice displayed comparable cell proliferation rates. Chronically DDC-intoxicated krt18⁻/⁻ and wt mice showed a similarly increased degree of steatohepatitis with hepatocyte ballooning and MDB formation. In krt8⁻/⁻ mice, steatosis was less, ballooning, and MDBs were absent. krt18⁻/⁻ mice developed MDBs whereas krt8⁻/⁻ mice on the same genetic background did not, highlighting the significance of different structural properties of keratins. They are independent of the genetic background as an intrinsic factor. By contrast, toxicity effects may depend on the genetic background. krt8⁻/⁻ and krt18⁻/⁻ mice on the same genetic background show similar sensitivity to DDC intoxication and almost resemble wt animals regarding survival, degree of porphyria, liver-to-body weight ratio, serum bilirubin and liver enzyme levels. This stands in contrast to previous work where krt8⁻/⁻ and krt18⁻/⁻ mice on different genetic backgrounds were investigated.

  17. Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse.

    Directory of Open Access Journals (Sweden)

    Srikant Ambatipudi

    Full Text Available Keratins are structural marker proteins with tissue specific expression; however, recent reports indicate their involvement in cancer progression. Previous study from our lab revealed deregulation of many genes related to structural molecular integrity including KRT76. Here we evaluate the role of KRT76 downregulation in oral precancer and cancer development.We evaluated KRT76 expression by qRT-PCR in normal and tumor tissues of the oral cavity. We also analyzed K76 expression by immunohistochemistry in normal, oral precancerous lesion (OPL, oral squamous cell carcinoma (OSCC and in hamster model of oral carcinogenesis. Further, functional implication of KRT76 loss was confirmed using KRT76-knockout (KO mice.We observed a strong association of reduced K76 expression with increased risk of OPL and OSCC development. The buccal epithelium of DMBA treated hamsters showed a similar trend. Oral cavity of KRT76-KO mice showed preneoplastic changes in the gingivobuccal epithelium while no pathological changes were observed in KRT76 negative tissues such as tongue.The present study demonstrates loss of KRT76 in oral carcinogenesis. The KRT76-KO mice data underlines the potential of KRT76 being an early event although this loss is not sufficient to drive the development of oral cancers. Thus, future studies to investigate the contributing role of KRT76 in light of other tumor driving events are warranted.

  18. Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.

    Science.gov (United States)

    Duverger, Olivier; Carlson, Jenna C; Karacz, Chelsea M; Schwartz, Mary E; Cross, Michael A; Marazita, Mary L; Shaffer, John R; Morasso, Maria I

    2018-01-01

    Pachyonychia congenita (PC) is a cutaneous disorder primarily characterized by nail dystrophy and painful palmoplantar keratoderma. PC is caused by mutations in KRT6A, KRT6B, KRT6C, KRT16, and KRT17, a set of keratin genes expressed in the nail bed, palmoplantar epidermis, oral mucosal epithelium, hair follicle and sweat gland. RNA-seq analysis revealed that all PC-associated keratins (except for Krt6c that does exist in the mouse genome) are expressed in the mouse enamel organ. We further demonstrated that these keratins are produced by ameloblasts and are incorporated into mature human enamel. Using genetic and intraoral examination data from 573 adults and 449 children, we identified several missense polymorphisms in KRT6A, KRT6B and KRT6C that lead to a higher risk for dental caries. Structural analysis of teeth from a PC patient carrying a p.Asn171Lys substitution in keratin-6a (K6a) revealed disruption of enamel rod sheaths resulting in altered rod shape and distribution. Finally, this PC-associated substitution as well as more frequent caries-associated SNPs, found in two of the KRT6 genes, that result in p.Ser143Asn substitution (rs28538343 in KRT6B and rs151117600 in KRT6C), alter the assembly of K6 filaments in ameloblast-like cells. These results identify a new set of keratins involved in tooth enamel formation, distinguish novel susceptibility loci for tooth decay and reveal additional clinical features of pachyonychia congenita.

  19. Thermodynamic Spectrum of Solar Flares Based on SDO/EVE Observations: Techniques and First Results

    Science.gov (United States)

    Wang, Yuming; Zhou, Zhenjun; Zhang, Jie; Liu, Kai; Liu, Rui; Shen, Chenglong; Chamberlin, Phillip C.

    2016-01-01

    The Solar Dynamics Observatory (SDO)/EUV Variability Experiment (EVE) provides rich information on the thermodynamic processes of solar activities, particularly on solar flares. Here, we develop a method to construct thermodynamic spectrum (TDS) charts based on the EVE spectral lines. This tool could potentially be useful for extreme ultraviolet (EUV) astronomy to learn about the eruptive activities on distant astronomical objects. Through several cases, we illustrate what we can learn from the TDS charts. Furthermore, we apply the TDS method to 74 flares equal to or greater than the M5.0 class, and reach the following statistical results. First, EUV peaks are always behind the soft X-ray (SXR) peaks and stronger flares tend to have faster cooling rates. There is a power-law correlation between the peak delay times and the cooling rates, suggesting a coherent cooling process of flares from SXR to EUV emissions. Second, there are two distinct temperature drift patterns, called Type I and Type II. For Type I flares, the enhanced emission drifts from high to low temperature like a quadrilateral, whereas for Type II flares the drift pattern looks like a triangle. Statistical analysis suggests that Type II flares are more impulsive than Type I flares. Third, for late-phase flares, the peak intensity ratio of the late phase to the main phase is roughly correlated with the flare class, and the flares with a strong late phase are all confined. We believe that the re-deposition of the energy carried by a flux rope, which unsuccessfully erupts out, into thermal emissions is responsible for the strong late phase found in a confined flare. Furthermore, we show the signatures of the flare thermodynamic process in the chromosphere and transition region in the TDS charts. These results provide new clues to advance our understanding of the thermodynamic processes of solar flares and associated solar eruptions, e.g., coronal mass ejections.

  20. THERMODYNAMIC SPECTRUM OF SOLAR FLARES BASED ON SDO/EVE OBSERVATIONS: TECHNIQUES AND FIRST RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yuming; Zhou, Zhenjun; Liu, Kai; Liu, Rui; Shen, Chenglong [CAS Key Laboratory of Geospace Environment, Department of Geophysics and Planetary Sciences, University of Science and Technology of China, Hefei, Anhui 230026 (China); Zhang, Jie [School of Physics, Astronomy and Computational Sciences, George Mason University, 4400 University Drive, MSN 6A2, Fairfax, VA 22030 (United States); Chamberlin, Phillip C., E-mail: ymwang@ustc.edu.cn [Solar Physics Laboratory, Heliophysics Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2016-03-15

    The Solar Dynamics Observatory (SDO)/EUV Variability Experiment (EVE) provides rich information on the thermodynamic processes of solar activities, particularly on solar flares. Here, we develop a method to construct thermodynamic spectrum (TDS) charts based on the EVE spectral lines. This tool could potentially be useful for extreme ultraviolet (EUV) astronomy to learn about the eruptive activities on distant astronomical objects. Through several cases, we illustrate what we can learn from the TDS charts. Furthermore, we apply the TDS method to 74 flares equal to or greater than the M5.0 class, and reach the following statistical results. First, EUV peaks are always behind the soft X-ray (SXR) peaks and stronger flares tend to have faster cooling rates. There is a power-law correlation between the peak delay times and the cooling rates, suggesting a coherent cooling process of flares from SXR to EUV emissions. Second, there are two distinct temperature drift patterns, called Type I and Type II. For Type I flares, the enhanced emission drifts from high to low temperature like a quadrilateral, whereas for Type II flares the drift pattern looks like a triangle. Statistical analysis suggests that Type II flares are more impulsive than Type I flares. Third, for late-phase flares, the peak intensity ratio of the late phase to the main phase is roughly correlated with the flare class, and the flares with a strong late phase are all confined. We believe that the re-deposition of the energy carried by a flux rope, which unsuccessfully erupts out, into thermal emissions is responsible for the strong late phase found in a confined flare. Furthermore, we show the signatures of the flare thermodynamic process in the chromosphere and transition region in the TDS charts. These results provide new clues to advance our understanding of the thermodynamic processes of solar flares and associated solar eruptions, e.g., coronal mass ejections.

  1. Keratin14 mRNA expression in human pneumocytes during quiescence, repair and disease.

    Directory of Open Access Journals (Sweden)

    Marco Confalonieri

    Full Text Available The lung alveoli slowly self-renew pneumocytes, but their facultative regeneration capacity is rapidly efficient after an injury, so fibrosis infrequently occurs. We recently observed Keratin 14 (KRT14 expression during diffuse alveolar damage (DAD, but not in controls. We wonder if KRT14 may be a marker of pneumocyte transition from quiescence to regeneration. Quantitative PCR and Western blot analyses highlighted the presence of KRT14 (mRNA and protein only in human lung samples with DAD or interstitial lung disease (ILD. In the exponentially growing cell lines A549 and H441, the mRNA and protein levels of KRT14 peaked at day one after cell seeding and decreased at day two, opposite to what observed for the proliferation marker E2F1. The inverse relation of KRT14 versus E2F1 expression holds true also for other proliferative markers, such as cyclin E1 and cyclin D1. Of interest, we also found that E2F1 silencing caused cell cycle arrest and increased KRT14 expression, whilst E2F1 stimulation induced cell cycle progression and decreased KRT14. KRT14 also increased in proliferative pneumocytes (HPAEpiC just before transdifferentiation. Overall, our results suggest that KRT14 is a viable biomarker of pneumocyte activation, and repair/regeneration. The involvement of KRT14 in regenerative process may suggest a novel pharmaceutical target to accelerate lung repair.

  2. The Stuff of Christmas Homemaking: Transforming the House and Church on Christmas Eve in the Bay of Kotor, Montenegro

    Directory of Open Access Journals (Sweden)

    Vesna Vučinić-Nešković

    2016-03-01

    Full Text Available The domestic burning of Yule logs on Christmas Eve is an archaic tradition characteristic of the Christian population in the central Balkans. In the fifty years following World War Two, the socialist state suppressed these and other popular religious practices. However, ethnographic research in Serbia and Montenegro in the late 1980s showed that many village households, nevertheless, preserved their traditional Christmas rituals at home, in contrast to the larger towns, in which they were practically eradicated. Even in the micro-regions, such as the Bay of Kotor, there were observable differences between more secluded rural communities, in which the open hearth is still the ritual center of the house (on which the Yule logs are burned as many as seven times during the Christmas season, and the towns in which only a few households continued with the rite (burning small logs in the wood-stove. In the early 1990s, however, a revival of domestic religious celebrations as well as their extension into the public realm has occurred. This study shows how on Christmas Eve, houses and churchyards (as well as townsquares are being transformed into sacred places. By analyzing the temporal and spatial aspects of this ritual event, the roles that the key actors play, the actions they undertake and artifacts they use, I attempt to demonstrate how the space of everyday life is transformed into a sacred home. In the end, the meanings and functions of homemaking are discussed in a way that confronts the classic distinction between private and public ritual environs.

  3. The EVE plus RHESSI DEM for Solar Flares, and Implications for Residual Non-Thermal X-Ray Emission

    Science.gov (United States)

    McTiernan, James; Caspi, Amir; Warren, Harry

    2016-05-01

    Solar flare spectra are typically dominated by thermal emission in the soft X-ray energy range. The low energy extent of non-thermal emission can only be loosely quantified using currently available X-ray data. To address this issue, we combine observations from the EUV Variability Experiment (EVE) on-board the Solar Dynamics Observatory (SDO) with X-ray data from the Reuven Ramaty High Energy Spectroscopic Imager (RHESSI) to calculate the Differential Emission Measure (DEM) for solar flares. This improvement over the isothermal approximation helps to resolve the ambiguity in the range where the thermal and non-thermal components may have similar photon fluxes. This "crossover" range can extend up to 30 keV.Previous work (Caspi et.al. 2014ApJ...788L..31C) concentrated on obtaining DEM models that fit both instruments' observations well. For this current project we are interested in breaks and cutoffs in the "residual" non-thermal spectrum; i.e., the RHESSI spectrum that is left over after the DEM has accounted for the bulk of the soft X-ray emission. As in our earlier work, thermal emission is modeled using a DEM that is parametrized as multiple gaussians in temperature. Non-thermal emission is modeled as a photon spectrum obtained using a thin-target emission model ('thin2' from the SolarSoft Xray IDL package). Spectra for both instruments are fit simultaneously in a self-consistent manner.For this study, we have examined the DEM and non-thermal resuidual emission for a sample of relatively large (GOES M class and above) solar flares observed from 2011 to 2014. The results for the DEM and non-thermal parameters found using the combined EVE-RHESSI data are compared with those found using only RHESSI data.

  4. Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Takashi Matsumoto

    2018-01-01

    Full Text Available Recent studies have demonstrated that flavonoid glucuronides can be deconjugated to the active form aglycone by β-glucuronidase-expressing macrophages. Keigairengyoto (KRT is a flavonoid-rich traditional Japanese medicine reported to enhance bacterial clearance through immune modulation. Our aims are to examine the pharmacokinetics of KRT flavonoids and to identify active flavonoids contributing to the adjuvant effects of KRT. KRT was evaluated at pharmacokinetic analysis to quantify absorbed flavonoids, and cutaneous infection assay induced in mice by inoculation of Staphylococcus aureus. Preventive or therapeutic KRT administration reduced the number of bacteria in the infection site as well as macroscopic and microscopic lesion scores with efficacies similar to antibiotics. Pharmacokinetic study revealed low plasma levels of flavonoid aglycones after KRT administration; however, plasma concentrations were enhanced markedly by β-glucuronidase treatment, with baicalein the most abundant (Cmax, 1.32 µg/mL. In random screening assays, flavonoids such as bacalein, genistein, and apigenin enhanced bacteria phagocytosis by macrophages. Glucuronide bacalin was converted to aglycone baicalein by incubation with living macrophages, macrophage lysate, or skin homogenate. Taken together, the adjuvant effect of KRT may be due to some blood-absorbed flavonoids which enhance macrophage functions in host defense. Flavonoid-rich KRT may be a beneficial treatment for infectious skin inflammation.

  5. [Sanitary service of West Special Military District on the eve and in the first days of the Great Patriotic War of 1941-1945].

    Science.gov (United States)

    Shelepov, A M; Ishutin, O S; Leonik, S I

    2011-06-01

    This article evaluates military and political situation in the world and operational-strategic environment on the West Theater of operations on the eve of the Great Patriotic War (1941-1945). We analyze structure and overall condition of sanitary service of West Special Military District of the Workers and Peasants Red Army and causes of failure of mobilization, organization and deployment of military units and establishments from the beginning of aggression of Fascist Germany to the Soviet Union.

  6. The Eroticism of Artificial Flesh in Villiers de L'Isle Adam's L'Eve Future

    Directory of Open Access Journals (Sweden)

    Patricia Pulham

    2008-10-01

    Full Text Available Villiers de L'Isle Adam's 'L'Eve Future' published in 1886 features a fictional version of the inventor Thomas Edison who constructs a complex, custom-made android for Englishman Lord Ewald as a substitute for his unsatisfactory lover. Hadaly, the android, has a number of literary and cultural precursors and successors. Her most commonly accepted ancestor is Olympia in E. T. A. Hoffmann's 'The Sandman' (1816 and among her fascinating descendants are Oskar Kokoschka's 'Silent Woman'; Model Borghild, a sex doll designed by German technicians during World War II;‘Caracas' in Tommaso Landolfi's short story ‘Gogol's Wife' (1954; a variety of gynoids and golems from the realms of science fiction, including Ira Levin's 'Stepford Wives' (1972; and, most recently, that silicon masterpiece - the Real Doll. All, arguably, have their genesis in the classical myth of Pygmalion. This essay considers the tension between animation and stasis in relation to this myth, and explores the necrophiliac aesthetic implicit in Villiers's novel.

  7. Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.

    Science.gov (United States)

    Fischer, Heinz; Langbein, Lutz; Reichelt, Julia; Buchberger, Maria; Tschachler, Erwin; Eckhart, Leopold

    2016-01-01

    K1 and K2 are the main type II keratins in the suprabasal epidermis where each of them heterodimerizes with the type I keratin K10 to form intermediate filaments. In regions of the ears, tail, and soles of the mouse, only K2 is co-expressed with K10, suggesting that these keratins suffice to form a mechanically resilient cytoskeleton. To determine the effects of the suppression of both main keratins, K2 and K10, in the suprabasal plantar epidermis of the mouse. Krt2(-/-) Krt10(-/-) mice were generated by crossing Krt2(-/-) and Krt10(-/-) mice. Epidermal morphology of soles of hind-paws was examined macroscopically and histologically. Immunofluorescence analysis and quantitative PCR analysis were performed to analyze the expression of keratins in sole skin of wildtype and Krt2(-/-) Krt10(-/-) mice. Highly abundant proteins of the sole stratum corneum were determined by electrophoretic and chromatographic separation and subsequent mass spectrometry. K2 and K10 are the most prominent suprabasal keratins in normal mouse soles with the exception of the footpads where K1, K9 and K10 predominate. Mice lacking both K2 and K10 were viable and developed epidermal acanthosis and hyperkeratosis in inter-footpad epidermis of the soles. The expression of keratins K1, K9 and K16 was massively increased at the RNA and protein levels in the soles of Krt2(-/-) Krt10(-/-) mice. This study demonstrates that the loss of the main cytoskeletal components of plantar epidermis, i.e. K2 and K10, can be only partly compensated by the upregulation of other keratins. The thickening of the epidermis in the soles of Krt2(-/-) Krt10(-/-) mice may serve as a model for pathomechanistic aspects of palmoplantar keratoderma. Copyright © 2015. Published by Elsevier Ireland Ltd.

  8. Start of enrolment for the Champs-Fréchets crèche (EVE)

    CERN Multimedia

    HR Department

    2008-01-01

    As announced in Bulletin 43/2007, CERN signed an agreement with the commune of Meyrin on 17 October 2007 under which 20 places will be reserved for the children of CERN personnel in the Champs-Fréchets day care centre (EVE), which will open on Monday, 25 August, and CERN will contribute to the funding. This agreement allows members of the CERN personnel (employees and associates) access to the crèche, for children aged between 4 months and 4 years, irrespective of where they are living. Applications for the school year starting autumn 2008 will be accepted from Monday 17 March until Monday 30 June 2008. Members of the personnel must complete the enrolment formalities with the Meyrin infant education service themselves: Mairie de Meyrin Service de la Petite Enfance 2 rue des Boudines Case postale 367 - 1217 Meyrin 1 - Tel. + 41 (0)22 782 21 21 mailto:meyrin@meyrin.ch http://www.meyrin.ch/petiteenfance Application forms (in PDF) can be downloaded from the website of the com...

  9. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1

    DEFF Research Database (Denmark)

    Chan, Carol W M; Wong, Newton A; Liu, Ying

    2009-01-01

    colorectal cancer cell lines. Deletion and mutation analysis of the KRT20 promoter showed that the minimum regulatory region for the control of KRT20 expression by CDX1 is within 246 bp upstream of the KRT20 transcription start site. ChIP analysis confirmed that CDX1 binds to the predicted CDX elements...... in this region of the KRT20 promoter in vivo. In addition, immunohistochemistry showed expression of CDX1 parallels that of KRT20 in the normal crypt, which further supports their close relationship. In summary, our observations strongly imply that KRT20 is directly regulated by CDX1, and therefore suggest...... a role for CDX1 in maintaining differentiation in intestinal epithelial cells. Because a key feature of the development of a cancer is an unbalanced program of proliferation and differentiation, dysregulation of CDX1 may be an advantage for the development of a colorectal carcinoma. This could, therefore...

  10. A surprise southern hemisphere meteor shower on New-Year's Eve 2015: the Volantids (IAU#758, VOL)

    Science.gov (United States)

    Jenniskens, P.; Baggaley, J.; Crumpton, I.; Aldous, P.; Gural, P. S.; Samuels, D.; Albers, J.; Soja, R.

    2016-04-01

    A new 32-camera CAMS network in New Zealand, spread over two stations on South Island, has detected a high southern declination shower that was active on New Year's Eve, 2015 December 31. During the observing interval from 09h12m - 15h45m UT, 21 out of 59 detected meteors radiated from the constellation of Volans, the flying fish, with a geocentric radiant at RA = 122.9 deg +- 4.7 deg, Dec = -71.9 deg +- 1.9 deg, and speed V_g = 28.4 +- 1.5 km/s. The new year arrived in New Zealand at 11h00m UT. Two more were detected the next night. No activity from this shower was observed the year prior. The meteoroids move in a 48 deg-inclined Jupiter-family comet orbit. The parent body has not yet been identified.

  11. Measurements of the branching fractions for the semileptonic decays D-s(+) -> phi e(+)v(e), phi mu(+)v(mu), eta mu(+)v(mu) and eta 'mu(+)v(mu)

    NARCIS (Netherlands)

    Ablikim, M.; Achasov, M.N.; Ahmed, S.; Albrecht, M.; Amoroso, A.; An, F. F.; An, Q.; Haddadi, Z.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Messchendorp, J. G.; Tiemens, M.

    2018-01-01

    By analyzing 482 pb(-1) of e(+) e(-) collision data collected at the center-of-mass energy root s = 4.009 GeV with the BESIII detector, we measure the branching fractions for the semi-leptonic decays D-s(+) -> phi e(+)v(e), phi mu(+)v(mu), eta mu(+)v(mu) and eta'mu(+)v(mu) to be B(D-s(+) -> phi

  12. Children’s Day-Care Centre (EVE) and School kicked off the school year 2016-2017

    CERN Multimedia

    Staff Association

    2016-01-01

    It has been 54 years already, ever since the Nursery school was founded in March 1961, that the Staff Association together with the teachers, the managerial and the administrative staff, welcomes your children at the start of the school year. On Tuesday, 30 August 2016, the Children’s Day-Care Centre (EVE) and School opened its doors again for children between four months and six years old. The start of the school year was carried out gradually and in small groups to allow quality interaction between children, professionals and parents. This year, our structure will accommodate about 130 children divided between the nursery, the kindergarten and the school. Throughout the school year, the children will work on the theme of colours, which will be the common thread linking all our activities. Our team is comprised of 38 people: the headmistress, the deputy headmistress, 2 secretaries, 13 educators, 4 teachers, 11 teaching assistants, 2 nursery assistants and 4 canteen workers. The team is delighted...

  13. Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development.

    Science.gov (United States)

    Rodrigues-Pinto, Ricardo; Berry, Andrew; Piper-Hanley, Karen; Hanley, Neil; Richardson, Stephen M; Hoyland, Judith A

    2016-08-01

    In humans, the nucleus pulposus (NP) is composed of large vacuolated notochordal cells in the fetus but, soon after birth, becomes populated by smaller, chondrocyte-like cells. Although animal studies indicate that notochord-derived cells persist in the adult NP, the ontogeny of the adult human NP cell population is still unclear. As such, identification of unique notochordal markers is required. This study was conducted to determine the spatiotemporal expression of putative human notochordal markers to aid in the elucidation of the ontogeny of adult human NP cells. Human embryos and fetuses (3.5-18 weeks post-conception (WPC)) were microdissected to isolate the spine anlagens (notochord and somites/sclerotome). Morphology of the developing IVD was assessed using hematoxylin and eosin. Expression of keratin (KRT) 8, KRT18, KRT19, CD24, GAL3, CD55, BASP1, CTGF, T, CD90, Tie2, and E-cadherin was assessed using immunohistochemistry. KRT8, KRT18, KRT19 were uniquely expressed by notochordal cells at all spine levels at all stages studied; CD24 was expressed at all stages except 3.5 WPC. While GAL3, CD55, BASP1, CTGF, and T were expressed by notochordal cells at specific stages, they were also co-expressed by sclerotomal cells. CD90, Tie2, and E-cadherin expression was not detectable in developing human spine cells at any stage. This study has identified, for the first time, the consistent expression of KRT8, KRT18, KRT19, and CD24 as human notochord-specific markers during early IVD development. Thus, we propose that these markers can be used to help ascertain the ontogeny of adult human NP cells. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 34:1327-1340, 2016. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc.

  14. Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord‐specific markers during early human intervertebral disc development

    Science.gov (United States)

    Rodrigues‐Pinto, Ricardo; Berry, Andrew; Piper‐Hanley, Karen; Hanley, Neil; Richardson, Stephen M.

    2016-01-01

    ABSTRACT In humans, the nucleus pulposus (NP) is composed of large vacuolated notochordal cells in the fetus but, soon after birth, becomes populated by smaller, chondrocyte‐like cells. Although animal studies indicate that notochord‐derived cells persist in the adult NP, the ontogeny of the adult human NP cell population is still unclear. As such, identification of unique notochordal markers is required. This study was conducted to determine the spatiotemporal expression of putative human notochordal markers to aid in the elucidation of the ontogeny of adult human NP cells. Human embryos and fetuses (3.5–18 weeks post‐conception (WPC)) were microdissected to isolate the spine anlagens (notochord and somites/sclerotome). Morphology of the developing IVD was assessed using hematoxylin and eosin. Expression of keratin (KRT) 8, KRT18, KRT19, CD24, GAL3, CD55, BASP1, CTGF, T, CD90, Tie2, and E‐cadherin was assessed using immunohistochemistry. KRT8, KRT18, KRT19 were uniquely expressed by notochordal cells at all spine levels at all stages studied; CD24 was expressed at all stages except 3.5 WPC. While GAL3, CD55, BASP1, CTGF, and T were expressed by notochordal cells at specific stages, they were also co‐expressed by sclerotomal cells. CD90, Tie2, and E‐cadherin expression was not detectable in developing human spine cells at any stage. This study has identified, for the first time, the consistent expression of KRT8, KRT18, KRT19, and CD24 as human notochord‐specific markers during early IVD development. Thus, we propose that these markers can be used to help ascertain the ontogeny of adult human NP cells. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 34:1327–1340, 2016. PMID:26910849

  15. Cytokeratin expression in mouse lacrimal gland germ epithelium.

    Science.gov (United States)

    Hirayama, Masatoshi; Liu, Ying; Kawakita, Tetsuya; Shimmura, Shigeto; Tsubota, Kazuo

    2016-05-01

    The lacrimal gland secretes tear fluids that protect the ocular surface epithelium, and its dysfunction leads to dry eye disease (DED). The functional restoration of the lacrimal gland by engraftment of a bioengineered lacrimal gland using lacrimal gland germ epithelial cells has been proposed to cure DED in mice. Here, we investigate the expression profile of cytokeratins in the lacrimal gland germ epithelium to clarify their unique characteristics. We performed quantitative polymerase chain reaction (Q-PCR) and immunohistochemistry (IHC) analysis to clarify the expression profile of cytokeratin in the lacrimal gland germ epithelium. The mRNA expression of keratin (KRT) 5, KRT8, KRT14, KRT15, and KRT18 in the lacrimal gland germ epithelium was increased compared with that in mouse embryonic stem cells and the lacrimal gland germ mesenchyme, as analyzed by Q-PCR. The expression level of KRT15 increased in the transition from stem cells to lacrimal gland germ epithelium, then decreased as the lacrimal gland matured. IHC revealed that the expression set of these cytokeratins in the lacrimal gland germ epithelium was different from that in the adult lacrimal gland. The expression of KRT15 was observed in the lacrimal gland germ epithelium, and it segmentalized into some of the basal cells in the intercanulated duct in mature gland. We determined the expression profile of cytokeratins in the lacrimal gland epithelium, and identified KRT15 as a candidate unique cellular marker for the lacrimal gland germ epithelium. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Moralized Hygiene and Nationalized Body: Anti-Cigarette Campaigns in China on the Eve of the 1911 Revolution

    Directory of Open Access Journals (Sweden)

    Wennan Liu

    2013-03-01

    Full Text Available Western knowledge about the injurious effects of cigarette smoking on smokers’ health appeared in the late nineteenth century and was shaped by both the Christian temperance movement and scientific developments in chemistry and physiology. Along with the increasing import of cigarettes into China, this new knowledge entered China through translations published at the turn of the twentieth century. It was reinterpreted and modified to dissuade the Chinese people from smoking cigarettes in two anti-cigarette campaigns: one launched by a former American missionary, Edward Thwing, in Tianjin, and a second by progressive social elites in Shanghai on the eve of the 1911 Revolution. By examining the rhetoric and practice of the campaigns, I argue that the discourse of hygiene they deployed moralized the individual habit of cigarette smoking as undermining national strength and endangering the future of the Chinese nation, thus helping to construct the idea of a nationalized body at this highly politically charged moment.

  17. Firework-related injuries in Tehran's Persian Wednesday Eve Festival (Chaharshanbe Soori).

    Science.gov (United States)

    Tavakoli, Hassan; Khashayar, Patricia; Amoli, Hadi Ahmadi; Esfandiari, Khalil; Ashegh, Hossein; Rezaii, Jalal; Salimi, Javad

    2011-03-01

    Fireworks are the leading cause of injuries such as burns and amputations during the Persian Wednesday Eve Festival (Chaharshanbeh Soori). This study was designed to explore the age of the high-risk population, the type of fireworks most frequently causing injury, the pattern of injury, and the frequency of permanent disabilities. This cohort study was performed by Tehran Emergency Medical Services at different medical centers all around Tehran, Iran, in individuals referred due to firework-related injuries during 1 month surrounding the festival in the year 2007. The following information was extracted from the patients' medical records: demographic data, the type of fireworks causing injury, the pattern and severity of the injury, the pre-hospital and hospital care provided for the patient, and the patient's condition at the time of discharge. In addition, information on the severity of the remaining disability was recorded 8 months after the injury. There were 197 patients enrolled in the study with a mean age of 20.94 ± 11.31 years; the majority of them were male. Fuse-detonated noisemakers and homemade grenades were the most frequent causes of injury. Hand injury was reported in 39.8% of the cases. Amputation and long-term disability were found in 6 and 12 cases, respectively. None of the patients died during the study period. The fireworks used during a Chaharshanbe Soori ceremony were responsible for a considerable number of injuries to different parts of the body, and some of them led to permanent disabilities. Copyright © 2011 Elsevier Inc. All rights reserved.

  18. Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

    Directory of Open Access Journals (Sweden)

    Lovestone Simon

    2007-12-01

    Full Text Available Abstract Background Shedding of the Alzheimer amyloid precursor protein (APP ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC or through unconventional phorbol-binding proteins such as Munc13-1. We have previously demonstrated that application of phorbol esters or purified PKC potentiates budding of APP-bearing secretory vesicles at the trans-Golgi network (TGN and toward the plasma membrane where APP becomes a substrate for enzymes responsible for shedding, known collectively as α-secretase(s. However, molecular identification of the presumptive "phospho-state-sensitive modulators of ectodomain shedding" (PMES responsible for regulated shedding has been challenging. Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1. Results Overexpression of either phorbol-sensitive wildtype Munc13-1 or phorbol-insensitive Munc13-1 H567K resulted in increased basal APP ectodomain shedding. However, in contrast to the report of Roßner et al (2004, phorbol ester-dependent APP ectodomain shedding from cells overexpressing APP and Munc13-1 wildtype was indistinguishable from that observed following application of phorbol to cells overexpressing APP and Munc13-1 H567K mutant. This pattern of similar effects on basal and stimulated APP shedding was also observed for Munc18 and NSF. Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious role in regulated shedding of sAPPα. Conclusion Our results indicate that, in the HEK293 system, Munc13-1, Munc18, NSF, and EVE-1 fail to meet essential criteria for identity as PMES for APP.

  19. Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.

    Science.gov (United States)

    Ikin, Annat F; Causevic, Mirsada; Pedrini, Steve; Benson, Lyndsey S; Buxbaum, Joseph D; Suzuki, Toshiharu; Lovestone, Simon; Higashiyama, Shigeki; Mustelin, Tomas; Burgoyne, Robert D; Gandy, Sam

    2007-12-09

    Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have previously demonstrated that application of phorbol esters or purified PKC potentiates budding of APP-bearing secretory vesicles at the trans-Golgi network (TGN) and toward the plasma membrane where APP becomes a substrate for enzymes responsible for shedding, known collectively as alpha-secretase(s). However, molecular identification of the presumptive "phospho-state-sensitive modulators of ectodomain shedding" (PMES) responsible for regulated shedding has been challenging. Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1. Overexpression of either phorbol-sensitive wildtype Munc13-1 or phorbol-insensitive Munc13-1 H567K resulted in increased basal APP ectodomain shedding. However, in contrast to the report of Rossner et al (2004), phorbol ester-dependent APP ectodomain shedding from cells overexpressing APP and Munc13-1 wildtype was indistinguishable from that observed following application of phorbol to cells overexpressing APP and Munc13-1 H567K mutant. This pattern of similar effects on basal and stimulated APP shedding was also observed for Munc18 and NSF. Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious role in regulated shedding of sAPPalpha. Our results indicate that, in the HEK293 system, Munc13-1, Munc18, NSF, and EVE-1 fail to meet essential criteria for identity as PMES for APP.

  20. Allowance officers Russian and Austro-Hungarian armies on the eve of the First World War

    Directory of Open Access Journals (Sweden)

    Alexander P. Abramov

    2016-09-01

    Full Text Available On the basis of historical material provides information on measures of state and military administration on the eve of the First World War to improve the welfare of Russian officers and Austro-Hungary, through various forms of material incentives, which are reflected in the cash payments, promotions, awards and social guarantees. On the basis of archival materials of the study period, open scientific publications and Internet resources there are disclosed the features of the destination of salaries, various allowances and compensations Russian army in comparison to the Austro-Hungarian army, who spoke Russian opponent in the First World War. The author notes that the existing system of money allowances in the Russian army was more advantageous than in the Austro-Hungarian army. However, neither one nor the other could not fully meet the needs of the majority of officers of both armies, entered as opponents in the First World War. One of its major shortcomings, both in Russia and in the Austro-Hungarian Empire, was a wide gap in the amounts of all kinds of money allowances between chief officers, staff officers and generals.

  1. A Novel Role for Keratin 17 in Coordinating Oncogenic Transformation and Cellular Adhesion in Ewing Sarcoma

    Science.gov (United States)

    Sankar, Savita; Tanner, Jason M.; Bell, Russell; Chaturvedi, Aashi; Randall, R. Lor; Beckerle, Mary C.

    2013-01-01

    Oncogenic transformation in Ewing sarcoma is caused by EWS/FLI, an aberrant transcription factor fusion oncogene. Glioma-associated oncogene homolog 1 (GLI1) is a critical target gene activated by EWS/FLI, but the mechanism by which GLI1 contributes to the transformed phenotype of Ewing sarcoma was unknown. In this work, we identify keratin 17 (KRT17) as a direct downstream target gene upregulated by GLI1. We demonstrate that KRT17 regulates cellular adhesion by activating AKT/PKB (protein kinase B) signaling. In addition, KRT17 is necessary for oncogenic transformation in Ewing sarcoma and accounts for much of the GLI1-mediated transformation function but via a mechanism independent of AKT signaling. Taken together, our data reveal previously unknown molecular functions for a cytoplasmic intermediate filament protein, KRT17, in coordinating EWS/FLI- and GLI1-mediated oncogenic transformation and cellular adhesion in Ewing sarcoma. PMID:24043308

  2. Testosterone regulates keratin 33B expression in rat penis growth through androgen receptor signaling.

    Science.gov (United States)

    Ma, Yan-Min; Wu, Kai-Jie; Dang, Qiang; Shi, Qi; Gao, Yang; Guo, Peng; Xu, Shan; Wang, Xin-Yang; He, Da-Lin; Gong, Yong-Guang

    2014-01-01

    Androgen therapy is the mainstay of treatment for the hypogonadotropic hypogonadal micropenis because it obviously enhances penis growth in prepubescent microphallic patients. However, the molecular mechanisms of androgen treatment leading to penis growth are still largely unknown. To clarify this well-known phenomenon, we successfully generated a castrated male Sprague Dawley rat model at puberty followed by testosterone administration. Interestingly, compared with the control group, testosterone treatment stimulated a dose-dependent increase of penis weight, length, and width in castrated rats accompanied with a dramatic recovery of the pathological changes of the penis. Mechanistically, testosterone administration substantially increased the expression of androgen receptor (AR) protein. Increased AR protein in the penis could subsequently initiate transcription of its target genes, including keratin 33B (Krt33b). Importantly, we demonstrated that KRT33B is generally expressed in the rat penis and that most KRT33B expression is cytoplasmic. Furthermore, AR could directly modulate its expression by binding to a putative androgen response element sequence of the Krt33b promoter. Overall, this study reveals a novel mechanism facilitating penis growth after testosterone treatment in precastrated prepubescent animals, in which androgen enhances the expression of AR protein as well as its target genes, such as Krt33b.

  3. Testosterone regulates keratin 33B expression in rat penis growth through androgen receptor signaling

    Directory of Open Access Journals (Sweden)

    Yan-Min Ma

    2014-12-01

    Full Text Available Androgen therapy is the mainstay of treatment for the hypogonadotropic hypogonadal micropenis because it obviously enhances penis growth in prepubescent microphallic patients. However, the molecular mechanisms of androgen treatment leading to penis growth are still largely unknown. To clarify this well-known phenomenon, we successfully generated a castrated male Sprague Dawley rat model at puberty followed by testosterone administration. Interestingly, compared with the control group, testosterone treatment stimulated a dose-dependent increase of penis weight, length, and width in castrated rats accompanied with a dramatic recovery of the pathological changes of the penis. Mechanistically, testosterone administration substantially increased the expression of androgen receptor (AR protein. Increased AR protein in the penis could subsequently initiate transcription of its target genes, including keratin 33B (Krt33b. Importantly, we demonstrated that KRT33B is generally expressed in the rat penis and that most KRT33B expression is cytoplasmic. Furthermore, AR could directly modulate its expression by binding to a putative androgen response element sequence of the Krt33b promoter. Overall, this study reveals a novel mechanism facilitating penis growth after testosterone treatment in precastrated prepubescent animals, in which androgen enhances the expression of AR protein as well as its target genes, such as Krt33b.

  4. Eesti ainus Lenin on hoiul / Sergei Stepanov

    Index Scriptorium Estoniae

    Stepanov, Sergei

    2003-01-01

    Narva Peetri platsil seisnud Lenini pronksskulptuurist (skulptor Olav Männi, arhitekt Borg), mille praegune asukoht on Narva kindluse territooriumil muuseumi eksponaadina. Kommentaarid Eldar Efendijevilt

  5. Jedinstvennõi Lenin Estonii hranitsja v Narve / Sergei Stepanov

    Index Scriptorium Estoniae

    Stepanov, Sergei

    2003-01-01

    Narva Peetri platsil seisnud Lenini pronksskulptuurist (skulptor Olav Männi, arhitekt Borg), mille praegune asukoht on Narva kindluse territooriumil muuseumi eksponaadina. Kommentaarid Eldar Efendijevilt

  6. Ammunition production in the USSR in 20-30 years of 20th century and efficiency of the Red Army in the eve and during of the Great Patriotic War

    Directory of Open Access Journals (Sweden)

    Андрей Николаевич Балыш

    2010-12-01

    Full Text Available The role of Ammunition Industry in connection with action variation at the first part of 20th century is analyzed in the present paper. It is studied how the New Economic Policy (NEP influenced onto the development of ammunition industry and respective branches of heavy industry. For the first time several manufacturing peculiarities of ammunition main elements (by example of ammunition bodies in the eve of the Great Patriotic War are analyzed on the base of archival documents and the role of these peculiarities in fighting efficiency of the Soviet forces during the Second World War is studied.

  7. Trace element analysis of blackish staining on the crowns of human archaeological teeth

    Energy Technology Data Exchange (ETDEWEB)

    Stermer, E.M. [Univ. of Oslo, Dept. of Oral Radiology, Oslo (Norway); Risnes, S. [Univ. of Oslo, Dept. of Oral Biology, Faculty of Dentistry, Oslo (Norway); Fischer, P.M. [Chalmers Univ. of Technology, Dept. of Physics, SIMS Lab., Goeteborg (Sweden)

    1996-10-01

    A blackish staining found on the crowns of teeth of 51 skulls from the excavation of the medieval St. Olav`s church in Trondheim was analyzed using secondary ion mass spectrometry (SIMS) and atomic absorption spectrometry (AAS). In four teeth, mass spectra and step scan concentration profiles of SIMS were performed and compared with the grey scale pattern in photographs of the analyzed paths. The manganese curve showed the highest degree of conformity with the grey scale pattern. The AAS analysis confirmed the increased content of manganese in blackish stained enamel. It was concluded that manganese, probably in the form of an oxide deposited from the soil, was the cause of the blackish staining. (au).

  8. Pop / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-2018

    2005-01-01

    Heliplaatidest: Olav Ehala "Armastatud laulud", Rein Rannap "Tantsib klaveril", Annie "Anniemal", Freeform Five "Strangest Things", Handsome Boy Modeling School "White People", Def Räädu "Planet Duckrabbit"

  9. Stand structure and regeneration of harvested Araucaria araucana ...

    African Journals Online (AJOL)

    Stand structure and regeneration of harvested Araucaria araucana–Nothofagus stands in central Chile. Rafael M Navarro-Cerrillo, Fernando Olave, Francisco Moreno, Sergio de Miguel, Margarita Clemente ...

  10. Vabadus ise mõelda / Olav Aarna

    Index Scriptorium Estoniae

    Aarna, Olav, 1942-

    2005-01-01

    Ilmunud ka: Lääne Elu 31. mai, lk. 2, Põhjarannik 31. mai, lk. 2, Severnoje Poberezhje 31. mai, lk. 2, Meie Maa 31. mai, lk.2, Sakala 1. juuni lk. 2, Nädaline, Lõunaleht, Koit 2. juuni lk. 2,2,6, Kuulutaja 3. juuni lk. 4, Valgamaalane 4. juuni lk. 2. Kordusartikkel Meie Maa 15. juuni lk. 2. Kahest Res Publica poolt algatatud eelnõust koolikorralduse muutmiseks

  11. Kooliuuendajate ja vanameelsete vaidlus / Olav Aarna

    Index Scriptorium Estoniae

    Aarna, Olav, 1942-

    2004-01-01

    Ilmunud ka: Võrumaa Teataja, 5. okt. 2004, lk. 2; Vali Uudised, 6. okt. 2004, lk. 2; Põhjarannik, 6. okt. 2004, lk. 2; Severnoje Poberezhje, 6. okt. 2004, lk. 2; Nädaline, 7. okt. 2004, lk. 5; Lääne Elu, 7. okt. 2004, lk. 2; Koit, 7. okt. 2004, lk. 6; Hiiu Leht, 8. okt. 2004, lk. 2; Meie Maa, 9. okt. 2004, lk. 2; Sakala, 14. okt. 2004, lk. 2. Hariduskorraldusest Eestis, vaidlused käivad autori sõnul kahe leeri vahel

  12. Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells.

    Directory of Open Access Journals (Sweden)

    Satoru Yoshida

    Full Text Available BACKGROUND: Application of induced pluripotent stem (iPS cells in regenerative medicine will bypass ethical issues associated with use of embryonic stem cells. In addition, patient-specific IPS cells can be useful to elucidate the pathophysiology of genetic disorders, drug screening, and tailor-made medicine. However, in order to apply iPS cells to mitotic tissue, induction of tissue stem cells that give rise to progeny of the target organ is required. METHODOLOGY/PRINCIPAL FINDINGS: We induced stratified epithelial cells from mouse iPS cells by co-culture with PA6 feeder cells (SDIA-method with use of BMP4. Clusters of cells positive for the differentiation markers KRT1 or KRT12 were observed in KRT14-positive colonies. We successfully cloned KRT14 and p63 double-positive stratified epithelial progenitor cells from iPS-derived epithelial cells, which formed stratified epithelial sheets consisting of five- to six-polarized epithelial cells in vitro. When these clonal cells were cultured on denuded mouse corneas, a robust stratified epithelial layer was observed with physiological cell polarity including high levels of E-cadherin, p63 and K15 expression in the basal layer and ZO-1 in the superficial layer, recapitulating the apico-basal polarity of the epithelium in vivo. CONCLUSIONS/SIGNIFICANCE: These results suggest that KRT14 and p63 double-positive epithelial progenitor cells can be cloned from iPS cells in order to produce polarized multilayer epithelial cell sheets.

  13. Aggregation server for grid-integrated vehicles

    Science.gov (United States)

    Kempton, Willett

    2015-05-26

    Methods, systems, and apparatus for aggregating electric power flow between an electric grid and electric vehicles are disclosed. An apparatus for aggregating power flow may include a memory and a processor coupled to the memory to receive electric vehicle equipment (EVE) attributes from a plurality of EVEs, aggregate EVE attributes, predict total available capacity based on the EVE attributes, and dispatch at least a portion of the total available capacity to the grid. Power flow may be aggregated by receiving EVE operational parameters from each EVE, aggregating the received EVE operational parameters, predicting total available capacity based on the aggregated EVE operational parameters, and dispatching at least a portion of the total available capacity to the grid.

  14. Kodaniku kohus on maksta makse / Märt Kubo

    Index Scriptorium Estoniae

    Kubo, Märt

    2002-01-01

    Dokumentaalfilm "Kodanik - riigi alus" : autor ja produtsent Rein Hanson : režissöörid Tambet Tasuja ja Marko Piirsoo : operaator Priit Murusalu : helilooja Olav Ehala : Läänemaa Telestuudio 2000

  15. Electric vehicle station equipment for grid-integrated vehicles

    Science.gov (United States)

    Kempton, Willett; Kiamilev, Fouad; McGee, Rodney; Waite, Nick

    2017-09-05

    Methods, systems, and apparatus transferring power between the grid and an electric vehicle are disclosed. The apparatus may include at least one vehicle communication port for interfacing with electric vehicle equipment (EVE) and a processor coupled to the at least one vehicle communication port to establish communication with the EVE, receive EVE attributes from the EVE, and transmit electric vehicle station equipment (EVSE) attributes to the EVE. Power may be transferred between the grid and the electric vehicle by maintaining EVSE attributes, establishing communication with the EVE, and transmitting the EVSE maintained attributes to the EVE.

  16. Helilooja sõnateatris / Mari Amor

    Index Scriptorium Estoniae

    Amor, Mari, 1973-

    2006-01-01

    Helilooja loodud originaalmuusika kasutamisest eesti sõnateatris, koostööst lavastajaga. Sõnalavastuste muusikalisest kujundusest avaldavad arvamust ka Viive Ernesaks, Ardo Ran Varres, Olav Ehala, Eino Tamberg, Mati Unt ja Rein Agur

  17. Jedinstvennõi Lenin Estonii hranitsja v Narve / Sergei Stepanov

    Index Scriptorium Estoniae

    Stepanov, Sergei

    2003-01-01

    Narvas Peetri väljakul asunud Lenini kuju (skulptor Olav Männi, 1957) saatusest. Demonteeriti 1993. a. ja viidi Narva muuseumi territooriumile, kus ta on ainus Eestis avalikus paigas asuv Lenini kuju

  18. Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε

    International Nuclear Information System (INIS)

    Liffers, Sven-T; Schwarte-Waldhoff, Irmgard; Meyer, Helmut E; Stühler, Kai; Hahn, Stephan A; Maghnouj, Abdelouahid; Munding, Johanna B; Jackstadt, René; Herbrand, Ulrike; Schulenborg, Thomas; Marcus, Katrin; Klein-Scory, Susanne; Schmiegel, Wolff

    2011-01-01

    Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma cells was adequate to suppress tumorigenicity and invasive potential, whereas in vitro cell growth was not affected. Using this cellular model system, we searched for new Smad4 targets comparing nuclear subproteomes derived from Smad4 re-expressing and Smad4 negative SW480 cells. High resolution two-dimensional (2D) gel electrophoresis was applied to identify novel Smad4 targets in the nuclear subproteome of Smad4 re-expressing SW480 cells. The identified candidate protein Keratin 23 was further characterized by tandem affinity purification. Immunoprecipitation, subfractionation and immunolocalization studies in combination with RNAi were used to validate the Keratin 23-14-3-3ε interaction. We identified keratins 8 and 18, heat shock proteins 60 and 70, plectin 1, as well as 14-3-3ε and γ as novel proteins present in the KRT23-interacting complex. Co-immunoprecipitation and subfractionation analyses as well as immunolocalization studies in our Smad4-SW480 model cells provided further evidence that KRT23 associates with 14-3-3ε and that Smad4 dependent KRT23 up-regulation induces a shift of the 14-3-3ε protein from a nuclear to a cytoplasmic localization. Based on our findings we propose a new regulatory circuitry involving Smad4 dependent up-regulation of KRT23 (directly or indirectly) which in turn modulates the interaction between KRT23 and 14-3-3ε leading to a cytoplasmic sequestration of 14-3-3ε. This cytoplasmic KRT23-14-3-3 interaction may alter the functional status of the well described 14-3-3 scaffold protein, known to regulate key cellular processes, such as signal transduction, cell cycle control, and apoptosis and may thus be a previously unappreciated facet of the Smad4 tumor suppressive circuitry

  19. Pila paatose asemel / Mari Laaniste

    Index Scriptorium Estoniae

    Laaniste, Mari, 1977-

    2007-01-01

    Dokumentaalfilm animaator Priit Pärnast "Mees animatsioonist" : režissöör Hardi Volmer : peaprodutsent ja operaator Arko Okk : stsenarist Toomas Kall : helilooja Olav Ehala : Acuba Film 2005. Lisatud andmed H. Volmeri kohta

  20. Harvardi tudengid saavad seksiteemalise ajakirja / Kristel Kossar

    Index Scriptorium Estoniae

    Kossar, Kristel

    2004-01-01

    Harvardi ülikooli tudengid plaanivad hakata välja andma ajakirja H-Bomb, mis kajastaks seksiteemat Harvardi vaatevinklist. Kommenteerivad TÜ teabejuht Illari Lään, TTÜ teabejuht Tiit Sinissaar ja Riigikogu kultuurikomisjoni esimees Olav Aarna

  1. Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

    International Nuclear Information System (INIS)

    Carén, Helena; Djos, Anna; Nethander, Maria; Sjöberg, Rose-Marie; Kogner, Per; Enström, Camilla; Nilsson, Staffan; Martinsson, Tommy

    2011-01-01

    Epigenetic mechanisms such as DNA methylation and histone modifications are important regulators of gene expression and are frequently involved in silencing tumor suppressor genes. In order to identify genes that are epigenetically regulated in neuroblastoma tumors, we treated four neuroblastoma cell lines with the demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-dC) either separately or in conjunction with the histone deacetylase inhibitor trichostatin A (TSA). Expression was analyzed using whole-genome expression arrays to identify genes activated by the treatment. These data were then combined with data from genome-wide DNA methylation arrays to identify candidate genes silenced in neuroblastoma due to DNA methylation. We present eight genes (KRT19, PRKCDBP, SCNN1A, POU2F2, TGFBI, COL1A2, DHRS3 and DUSP23) that are methylated in neuroblastoma, most of them not previously reported as such, some of which also distinguish between biological subsets of neuroblastoma tumors. Differential methylation was observed for the genes SCNN1A (p < 0.001), PRKCDBP (p < 0.001) and KRT19 (p < 0.01). Among these, the mRNA expression of KRT19 and PRKCDBP was significantly lower in patients that have died from the disease compared with patients with no evidence of disease (fold change -8.3, p = 0.01 for KRT19 and fold change -2.4, p = 0.04 for PRKCDBP). In our study, a low methylation frequency of SCNN1A, PRKCDBP and KRT19 is significantly associated with favorable outcome in neuroblastoma. It is likely that analysis of specific DNA methylation will be one of several methods in future patient therapy stratification protocols for treatment of childhood neuroblastomas

  2. THE FOREIGN POLICY OF THE BOLSHEVIKS ON THE EVE OF THE PARIS PEACE CONFERENCE OF 1919

    Directory of Open Access Journals (Sweden)

    Elena Nikolaevna Emelyanova

    2017-11-01

    Full Text Available Purpose. The article examines the foreign policy activities of the Bolshevik leadership on the eve of the opening of the Paris Peace Conference. The strategy and tactics of the RCP (B in the autumn-winter of 1918–1919 are analyzed, as well as the attempt to establish relations with the great powers hostile to the RSFSR, the striving of Soviet Russia to take its place in the new Versailles system. The ways to achieve this goal are exploring. The methodological basis of the article are the principles of objectivity, historicism, a critical approach to the sources used and a comprehensive analysis of the problem posed. Results: it is argued that the international situation, the growth of the revolutionary movement in Europe in 1918–1919, the unification of all left-wing forces around the Soviet state forced the leaders of Britain and the US to send their representative for talks with the Bolsheviks. On the other hand, the Bolshevik leadership sought to reach agreement with the world powers on recognizing the Soviet government, even by temporarily abandoning international goals, the implementation of these tasks was delegated to the Communist International created in March 1919. The preservation of the Soviet state was put by the Bolsheviks above the idea of a “world revolution”. Scope of application of the results. The results of the work can be used for further research in the field of history and political science, as well as in the teaching of these disciplines in the university.

  3. Limits on light WIMPs with a 1 kg-scale germanium detector at 160 eVee physics threshold at the China Jinping Underground Laboratory

    Science.gov (United States)

    Yang, Li-Tao; Li, Hau-Bin; Yue, Qian; Kang, Ke-Jun; Cheng, Jian-Ping; Li, Yuan-Jing; Tsz-King Wong, Henry; Aǧartioǧlu, M.; An, Hai-Peng; Chang, Jian-Ping; Chen, Jing-Han; Chen, Yun-Hua; Deng, Zhi; Du, Qiang; Gong, Hui; He, Li; Hu, Jin-Wei; Hu, Qing-Dong; Huang, Han-Xiong; Jia, Li-Ping; Jiang, Hao; Li, Hong; Li, Jian-Min; Li, Jin; Li, Xia; Li, Xue-Qian; Li, Yu-Lan; Lin, Fong-Kay; Lin, Shin-Ted; Liu, Shu-Kui; Liu, Zhong-Zhi; Ma, Hao; Ma, Jing-Lu; Pan, Hui; Ren, Jie; Ruan, Xi-Chao; Sevda, B.; Sharma, Vivek; Shen, Man-Bin; Singh, Lakhwinder; Singh, Manoj Kumar; Tang, Chang-Jian; Tang, Wei-You; Tian, Yang; Wang, Ji-Min; Wang, Li; Wang, Qing; Wang, Yi; Wu, Shi-Yong; Wu, Yu-Cheng; Xing, Hao-Yang; Xu, Yin; Xue, Tao; Yang, Song-Wei; Yi, Nan; Yu, Chun-Xu; Yu, Hai-Jun; Yue, Jian-Feng; Zeng, Xiong-Hui; Zeng, Ming; Zeng, Zhi; Zhang, Yun-Hua; Zhao, Ming-Gang; Zhao, Wei; Zhou, Ji-Fang; Zhou, Zu-Ying; Zhu, Jing-Jun; Zhu, Zhong-Hua; CDEX Collaboration

    2018-01-01

    We report results of a search for light weakly interacting massive particle (WIMP) dark matter from the CDEX-1 experiment at the China Jinping Underground Laboratory (CJPL). Constraints on WIMP-nucleon spin-independent (SI) and spin-dependent (SD) couplings are derived with a physics threshold of 160 eVee, from an exposure of 737.1 kg-days. The SI and SD limits extend the lower reach of light WIMPs to 2 GeV and improve over our earlier bounds at WIMP mass less than 6 GeV. Supported by the National Key Research and Development Program of China (2017YFA0402200, 2017YFA0402201), the National Natural Science Foundation of China (11175099, 11275107, 11475117, 11475099, 11475092, 11675088), the National Basic Research Program of China (973 Program) (2010CB833006). We thank the support of grants from the Tsinghua University Initiative Scientific Research Program (20121088494, 20151080354) and the Academia Sinica Investigator Award 2011-15, contracts 103-2112-M-001-024 and 104-2112-M-001-038-MY3 from the Ministry of Science and Technology of Taiwan.

  4. Igaühele hea haridus!? / Olav Aarna

    Index Scriptorium Estoniae

    Aarna, Olav, 1942-

    2005-01-01

    Ilmunud ka: Järva Teataja 1. september lk. 2, Meie Maa 1. september lk. 2, Koit 1. september lk. 6, Severnoje Poberezhje 1. september lk. 2, Vali Uudised 2. september lk. 2, Sakala 2. september lk. 2, Hiiu Leht 2. september lk. 2, Kuulutaja 2. september lk. 4, Nädaline 8. september lk. 4. Riigikogu kultuurikomisjoni esimehe sõnul peaks igaüks sõnastama enda jaoks rahuldava vastuse küsimusele, mis on hea haridus

  5. Kohtusid 37 riigi ajalooõpetajad / Olav Kruus

    Index Scriptorium Estoniae

    Kruus, Olav

    2001-01-01

    14.-18. märtsini toimus Tallinnas ajalooõpetajate assotsiatsiooni EUROCLIO (European Standing Conference of History Teachers Association) aastakonverents, kuhu saabus üle saja külalise 37 riigist. Konverentsi aruteluteema oli igapäevaelu käsitlemine ajalooõpetuses. 13. märtsil oli haridusministeeriumis minister Tõnis Lukase vastuvõtt õpilaste kodu-uurimuslikust võistlusest osa võtnud tublimatele õpilastele ja nende juhendajatele ning õpetajatele. 1999/2000. õa viidi Körberi Sihtasutuse ja Eesti Ajalooõpetajate Seltsi korraldatud õpilaste ajaloo-alaste uurimistööde võistlus läbi esimest korda. Teemaks oli "Eesti kodu ja pere XX sajandil". 2000. a kuulutati välja uus võistlus teemal "Eesti kool".

  6. Lotte ning ta sõbrad ja sugulased ehk Kas vägivallatus võib olla põnev / Leelo Tungal

    Index Scriptorium Estoniae

    Tungal, Leelo, 1947-

    2001-01-01

    Joonisfilmid "Lotte" ja "Lotte reis lõunamaale" : stsenaristid Andrus Kivirähk, Janno Põldma, Heiki Ernits : kunstnik Heiki Ernits : lavastajad Leo Lätti, Ebe Tramberg : helilooja Olav Ehala : Eesti Joonisfilm 2000. Lisa : S. Teinemaa koostatud J. Põldma ja H. Ernitsa filmograafia

  7. A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury

    Directory of Open Access Journals (Sweden)

    Samal Zhussupbekova

    2016-07-01

    Full Text Available A validated animal model would assist with research on the immunological consequences of the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human pre-malignant hyperproliferative epithelium. Here we examine keratin gene expression profile in skin from mice expressing the E7 oncoprotein of HPV16 (K14E7 demonstrating persistently hyperproliferative epithelium, in nontransgenic mouse skin, and in hyperproliferative actinic keratosis lesions from human skin. We demonstrate that K14E7 mouse skin overexpresses stress keratins in a similar manner to human actinic keratoses, that overexpression is a consequence of epithelial hyperproliferation induced by E7, and that overexpression further increases in response to injury. As stress keratins modify local immunity and epithelial cell function and differentiation, the K14E7 mouse model should permit study of how continued overexpression of stress keratins impacts on epithelial tumor development and on local innate and adaptive immunity.

  8. Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis

    Directory of Open Access Journals (Sweden)

    Elia Beniash

    2017-10-01

    Full Text Available Recent discovery of hair follicle keratin 75 (KRT75 in enamel raises questions about the function of this protein in enamel and the mechanisms of its secretion. It is also not clear how this protein with a very specific and narrow expression pattern, limited to the inner root sheath of the hair follicle, became associated with enamel. We propose a hypothesis that KRT75 was co-opted by ameloblasts during the evolution of Tomes' process and the prismatic enamel in synapsids.

  9. Rahvusooperi Estonia 99. hooaeg algab nädala pärast / Christel Karits

    Index Scriptorium Estoniae

    Karits, Christel, 1966-

    2004-01-01

    Muusikaturu korraldamisest 18. sept. Estonia teatrihoone taga ajaloolisel turuplatsil. Katri Kaasik-Aaslavi ja Vaino Vahingu näidendi "Teatriromanss" (muusika arranzheerija ja pianist Olav Ehala) esietendusest Estonia kammersaalis 22. oktoobril. Giuseppe Verdi ooperi "Aida" etendamisest Rocca al Mare Onistar Tennisekeskuses 8.-10., 12.-17. oktoobril

  10. Adam, Eve and the reflux enigma: age and sex differences across the gastro-oesophageal reflux spectrum.

    Science.gov (United States)

    Royston, Christine; Bardhan, Karna D

    2017-06-01

    We present demographic differences across the gastro-oesophageal reflux disease (GORD) spectrum in a UK District General Hospital. Data were prospectively collected over 37 years. At endoscopy patients were categorized as: erosive oesophagitis (EO), Barrett's oesophagus (BO) or nonerosive reflux disease (NER). Analysis 1: comparison of EO, BO and NER 1977-2001 when the database for GORD without BO closed. Analysis 2: demographic differences in oesophageal adenocarcinoma (OAC) in total BO population diagnosed 1977-2011. GORD 1977-2001 (n=11 944): sex, male predominance in EO and BO but not NER; male : female ratios, 1.81, 1.65, 0.87, respectively (P<0.0001); mean age at presentation, EO 54 years, BO 62 years, NER 50 years; women were older than men by 10, 7 and 6 years, respectively.BO 1977-2011: prevalent OAC, 87/1468 (6%); male : female ratio, 4.1 (P<0.0001); incident OAC, 54/1381 (3.9%); male : female ratio, 3.5 (P<0.0001). Among all BO, more men developed OAC (3 vs. 0.9%). Within each sex, proportion of OAC higher among men (4.9 vs. 2.3%); at OAC diagnosis women were slightly but not significantly older (69.9 vs. 72.3 years, P=0.322). Two views may explain our findings. First, women have either milder reflux, or reduced mucosal sensitivity hence reflux remains silent for longer. Alternatively, women genuinely develop reflux later, that is, are more protected and for longer from developing GORD and its complications. Early evidence is emerging that female sex hormones may indeed have a protective role in GORD during the reproductive period. We suggest reflux and its consequences may be an example of 'protection' conferred on Eve.

  11. Deklaratsioon = Declaration / Jaan Sõrra

    Index Scriptorium Estoniae

    Sõrra, Jaan, 1954-

    2006-01-01

    Konverentsi "580 päeva Euroopa Liidus " osalejate pöördumine. Vt ka vastused deklaratsioonile lk. 103-107 riigisekretär Heiki Loot, põllumajandusminister Ester Tuiksoo, haridus- ja teadusminister Mailis Reps, keskkonnaminister Villu Reiljan, Riigikogu kultuurikomisjon Olav Aarna, rahandusminister Aivar Sõerd ja Aare Järvan

  12. ["Should the staff's attitude towards the patients remain unchanged, I will not guarantee anything." Protest masculinity and coping of "rebellious patients" at the Heidelberg University Psychiatric Hospital on the eve of deinstitutionalization].

    Science.gov (United States)

    Schwamm, Christoph

    2015-01-01

    This article analyses the illness experiences of male patients from the Heidelberg University Psychiatric Hospital during the protests against Psychiatry in the year 1973. Protest is one of the most important expressions of masculinity in socially disadvantaged men, such as men with mental disorders. The analysis of 100 medical records shows that some patients tried to construct themselves as men in a way that was explicitly motivated by antipsychiatric ideas: They questioned psychiatric authority, behaved "sexually inappropriate", or used drugs. On the eve of psychiatric reform in West Germany those patients were well aware that the alternative--complying with the treatment--would put them at considerable risk. In addition to the usual inference of hegemonic or normative masculinities as risk-factors, the behavior of those ,,rebellious patients" has to be interpreted as individual coping strategies.

  13. Observations of sea-ice conditions in the Antarctic coastal region using ship-board video cameras

    Directory of Open Access Journals (Sweden)

    Haruhito Shimoda

    1997-03-01

    Full Text Available During the 30th, 31st, and 32nd Japanese Antarctic Research Expeditions (JARE-30,JARE-31,and JARE-32, sea-ice conditions were recorded by video camera on board the SHIRASE. Then, the sea-ice images were used to estimate compactness and thickness quantitatively. Analyzed legs are those toward Breid Bay and from Breid Bay to Syowa Station during JARE-30 and JARE-31,and those toward the Prince Olav Coast, from the Prince Olav Coast to Breid Bay, and from Breid Bay to Syowa Station during JARE-32. The results show yearly variations of ice compactness and thickness, latitudinal variations of thickness, and differences in thickness histograms between JARE-30 and JARE-32 in Lutzow-Holm Bay. Albedo values were measured simultaneously by a shortwave radiometer. These values are proportional to those of ice compactness. Finally, we examined the relationship between ice compactness and vertical gradient of air temperature above sea ice.

  14. Dose intensity and efficacy of the combination of everolimus and exemestane (EVE/EXE) in a real-world population of hormone receptor-positive (ER+/PgR+), HER2-negative advanced breast cancer (ABC) patients: a multicenter Italian experience.

    Science.gov (United States)

    Ciccarese, Mariangela; Fabi, Alessandra; Moscetti, Luca; Cazzaniga, Maria Elena; Petrucelli, Luciana; Forcignanò, Rosachiara; Lupo, Laura Isabella; De Matteis, Elisabetta; Chiuri, Vincenzo Emanuele; Cairo, Giuseppe; Febbraro, Antonio; Giordano, Guido; Giampaglia, Marianna; Bilancia, Domenico; La Verde, Nicla; Maiello, Evaristo; Morritti, Maria; Giotta, Francesco; Lorusso, Vito; Latorre, Agnese; Scavelli, Claudio; Romito, Sante; Cusmai, Antonio; Palmiotti, Gennaro; Surico, Giammarco

    2017-06-01

    This retrospective analysis focused on the effect of treatment with EVE/EXE in a real-world population outside of clinical trials. We examined the efficacy of this combination in terms of PFS and RR related to dose intensity (5 mg daily versus 10 mg daily) and tolerability. 163 HER2-negative ER+/PgR+ ABC patients, treated with EVE/EXE from May 2011 to March 2016, were included in the analysis. The primary endpoints were the correlation between the daily dose and RR and PFS, as well as an evaluation of the tolerability of the combination. Secondary endpoints were RR, PFS, and OS according to the line of treatment. Patients were classified into three different groups, each with a different dose intensity of everolimus (A, B, C). RR was 29.8% (A), 27.8% (B) (p = 0.953), and not evaluable (C). PFS was 9 months (95% CI 7-11) (A), 10 months (95% CI 9-11) (B), and 5 months (95% CI 2-8) (C), p = 0.956. OS was 38 months (95% CI 24-38) (A), median not reached (B), and 13 months (95% CI 10-25) (C), p = 0.002. Adverse events were stomatitis 57.7% (11.0% grade 3-4), asthenia 46.0% (6.1% grade 3-4), hypercholesterolemia 46.0% (0.6% grade 3-4), and hyperglycemia 35.6% (5.5% grade 3-4). The main reason for discontinuation/interruption was grade 2-3 stomatitis. No correlation was found between dose intensity (5 vs. 10 mg labeled dose) and efficacy in terms of RR and PFS. The tolerability of the higher dose was poor in our experience, although this had no impact on efficacy.

  15. Anomalous Temporal Behaviour of Broadband Ly Alpha Observations During Solar Flares from SDO/EVE

    Science.gov (United States)

    Milligan, Ryan O.; Chamberlin, Phillip C.

    2016-01-01

    Although it is the most prominent emission line in the solar spectrum, there has been a notable lack of studies devoted to variations in Lyman-alpha (Ly-alpha) emission during solar flares in recent years. However, the few examples that do exist have shown Ly-alpha emission to be a substantial radiator of the total energy budget of solar flares (of the order of 10 percent). It is also a known driver of fluctuations in the Earth's ionosphere. The EUV (Extreme Ultra-Violet) Variability Experiment (EVE) on board the Solar Dynamics Observatory (SDO) now provides broadband, photometric Ly-alpha data at 10-second cadence with its Multiple EUV Grating Spectrograph-Photometer (MEGS-P) component, and has observed scores of solar flares in the 5 years since it was launched. However, the MEGS-P time profiles appear to display a rise time of tens of minutes around the time of the flare onset. This is in stark contrast to the rapid, impulsive increase observed in other intrinsically chromospheric features (H-alpha, Ly-beta, LyC, C III, etc.). Furthermore, the emission detected by MEGS-P peaks around the time of the peak of thermal soft X-ray emission and not during the impulsive phase when energy deposition in the chromosphere (often assumed to be in the form of non-thermal electrons) is greatest. The time derivative of Ly-alpha lightcurves also appears to resemble that of the time derivative of soft X-rays, reminiscent of the Neupert effect. Given that spectrally-resolved Ly-alpha observations during flares from SORCE / SOLSTICE (Solar Radiation and Climate Experiment / Solar Stellar Irradiance Comparison Experiment) peak during the impulsive phase as expected, this suggests that the atypical behaviour of MEGS-P data is a manifestation of the broadband nature of the observations. This could imply that other lines andor continuum emission that becomes enhanced during flares could be contributing to the passband. Users are hereby urged to exercise caution when interpreting

  16. Spectroscopic Diagnostics of the Non-Maxwellian κ-distributions Using SDO/EVE Observations of the 2012 March 7 X-class Flare

    Science.gov (United States)

    Dzifčáková, Elena; Zemanová, Alena; Dudík, Jaroslav; Mackovjak, Šimon

    2018-02-01

    Spectroscopic observations made by the Extreme Ultraviolet Variability Experiment (EVE) on board the Solar Dynamics Observatory (SDO) during the 2012 March 7 X5.4-class flare (SOL2012-03-07T00:07) are analyzed for signatures of the non-Maxwellian κ-distributions. Observed spectra were averaged over 1 minute to increase photon statistics in weaker lines and the pre-flare spectrum was subtracted. Synthetic line intensities for the κ-distributions are calculated using the KAPPA database. We find strong departures (κ ≲ 2) during the early and impulsive phases of the flare, with subsequent thermalization of the flare plasma during the gradual phase. If the temperatures are diagnosed from a single line ratio, the results are strongly dependent on the value of κ. For κ = 2, we find temperatures about a factor of two higher than the commonly used Maxwellian ones. The non-Maxwellian effects could also cause the temperatures diagnosed from line ratios and from the ratio of GOES X-ray channels to be different. Multithermal analysis reveals the plasma to be strongly multithermal at all times with flat DEMs. For lower κ, the {{DEM}}κ are shifted toward higher temperatures. The only parameter that is nearly independent of κ is electron density, where we find log({n}{{e}} [{{cm}}-3]) ≈ 11.5 almost independently of time. We conclude that the non-Maxwellian effects are important and should be taken into account when analyzing solar flare observations, including spectroscopic and imaging ones.

  17. The Multi-Instrument (EVE-RHESSI) DEM for Solar Flares, and Implications for Residual Non-Thermal Soft X-Ray Emission

    Science.gov (United States)

    McTiernan, James M.; Caspi, Amir; Warren, Harry

    2015-04-01

    In the soft X-ray energy range, solar flare spectra are typically dominated by thermal emission. The low energy extent of non-thermal emission can only be loosely quantified using currently available X-ray data. To address this issue, we combine observations from the EUV Variability Experiment (EVE) on-board the Solar Dynamics Observatory (SDO) with X-ray data from the Reuven Ramaty High Energy Spectroscopic Imager (RHESSI). The improvement over the isothermal approximation is intended to resolve the ambiguity in the range where the thermal and non-thermal components may have similar photon fluxes. This "crossover" range can extend up to 30 keV for medium to large solar flares.Previous work (Caspi et.al. 2014ApJ...788L..31C) has concentrated on obtaining DEM models that fit both instruments' observations well. Now we are interested in any breaks and cutoffs in the "residual" non-thermal spectrum; i.e., the RHESSI spectrum that is left over after the DEM has accounted for the bulk of the soft X-ray emission. Thermal emission is again modeled using a DEM that is parametrized as multiple gaussians in temperature; the non-thermal emission is modeled as a photon spectrum obtained using a thin-target emission model ('thin2' from the SolarSoft Xray IDL package). Spectra for both instruments are fit simultaneously in a self-consistent manner. The results for non-thermal parameters then are compared with those found using RHESSI data alone, with isothermal and double-thermal models.

  18. Ühiselt Eesti põllumehe kaitsel / Olav Kreen

    Index Scriptorium Estoniae

    Kreen, Olav

    2004-01-01

    Eesti Põllumajandus-Kaubanduskoja poolt 30. jaanuaril 2004. a. Haapsalus korraldatud seminarist, kus tutvustati Taani ja Belgia põllumajandusorganisatsioone ning Euroopa põllumajandusorganisatsiooni COPA/COGECA

  19. Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles

    DEFF Research Database (Denmark)

    Greenwold, Matthew J.; Bao, Weier; Jarvis, Erich D.

    2014-01-01

    BACKGROUND: Vertebrate skin appendages are constructed of keratins produced by multigene families. Alpha (α) keratins are found in all vertebrates, while beta (β) keratins are found exclusively in reptiles and birds. We have studied the molecular evolution of these gene families in the genomes...... of 48 phylogenetically diverse birds and their expression in the scales and feathers of the chicken. RESULTS: We found that the total number of α-keratins is lower in birds than mammals and non-avian reptiles, yet two α-keratin genes (KRT42 and KRT75) have expanded in birds. The β-keratins, however...

  20. How calibration and reference spectra affect the accuracy of absolute soft X-ray solar irradiance measured by the SDO/EVE/ESP during high solar activity

    Science.gov (United States)

    Didkovsky, Leonid; Wieman, Seth; Woods, Thomas

    2016-10-01

    The Extreme ultraviolet Spectrophotometer (ESP), one of the channels of SDO's Extreme ultraviolet Variability Experiment (EVE), measures solar irradiance in several EUV and soft x-ray (SXR) bands isolated using thin-film filters and a transmission diffraction grating, and includes a quad-diode detector positioned at the grating zeroth-order to observe in a wavelength band from about 0.1 to 7.0 nm. The quad diode signal also includes some contribution from shorter wavelength in the grating's first-order and the ratio of zeroth-order to first-order signal depends on both source geometry, and spectral distribution. For example, radiometric calibration of the ESP zeroth-order at the NIST SURF BL-2 with a near-parallel beam provides a different zeroth-to-first-order ratio than modeled for solar observations. The relative influence of "uncalibrated" first-order irradiance during solar observations is a function of the solar spectral irradiance and the locations of large Active Regions or solar flares. We discuss how the "uncalibrated" first-order "solar" component and the use of variable solar reference spectra affect determination of absolute SXR irradiance which currently may be significantly overestimated during high solar activity.

  1. Kurumsal Sürdürülebilirlik Performansının Ölçümü İçin Çok Kriterli Bir Çerçeve: Henkel Örneği

    OpenAIRE

    Ahmet Öztel; Mehmet Said Köse; İhsan Aytekin

    2012-01-01

    Kurumsal sürdürülebilirlik performans ölçümü, kurumsal sürdürülebilirliğin çevresel, sosyal ve ekonomik yönlerini ele almayı amaçlamaktadır. Bu üç boyutun tek bir boyuta indirgenmesinde sorunlar ortaya çıkmaktadır. Çok kriterli karar verme yöntemleri, bu değişkenlerin birlikte değerlendirilmesi için kullanışlı bir çerçeve sunmaktadır. Bu çalışmada, çok kriterli karar verme yöntemlerinden uzlaşık programlama (compromise programing) çerçevesi kullanılarak Henkel firmasının kurumsal sürdürülebil...

  2. Linnateatri uhiuuel plaadil laulavad näitlejad Olav Ehala laule / Olav Ehala, Riina Roose ; intervjueerinud Maria Lee Liivak ; toimetanud Triin Sinissaar

    Index Scriptorium Estoniae

    Ehala, Olav, 1950-

    2010-01-01

    "Thijl Ulenspiegeli" lavastustest Eestis, heliplaadist "Thijl Ulenspiegel ja teisi laule". Plaadil esitavad O. Ehala muusikat Tallinna Linnateatri näitlejad Tallinna Kammerorkestri saatel. CD-plaadile salvestatud laule sai kuulda kontsertidel "Tallinna Linnateatel laulab. Õnnelik õhtu"

  3. Real-world effectiveness of everolimus-based therapy versus fulvestrant monotherapy in HR(+)/HER2(-) metastatic breast cancer.

    Science.gov (United States)

    Hao, Yanni; Lin, Peggy L; Xie, Jipan; Li, Nanxin; Koo, Valerie; Ohashi, Erika; Wu, Eric Q; Rogerio, Jaqueline

    2015-08-01

    Assessing real-world effectiveness of everolimus-based therapy (EVE) versus fulvestrant monotherapy (FUL) among postmenopausal women with hormone receptor-positive (HR(+))/HER2(-) metastatic breast cancer (mBC) after progression on nonsteroidal aromatase inhibitor (NSAI). Medical charts of community-based patients who received EVE or FUL for mBC after NSAI were examined. Progression-free survival (PFS), time on treatment and time to chemotherapy were compared using Kaplan-Meier curves and Cox proportional hazards models adjusting for line of therapy and patient characteristics. 192 patients received EVE and 156 FUL. After adjusting for patient characteristics, EVE was associated with significantly longer PFS than FUL (hazard ratio: 0.71; p = 0.045). EVE was associated with better PFS than FUL among NSAI-refractory postmenopausal HR(+)/HER2(-) mBC patients.

  4. В галерее SED ARTE открылась выставка "Натюрморт XXI века"

    Index Scriptorium Estoniae

    2011-01-01

    Galeriis SED ARTE avati 6. mail rahvusvaheline kunstinäitus "XXI sajandi natüürmort". Eksponeeritud on 47 kunstniku tööd Eestist, USA-st, Valgevenest, Ukrainast ja Venemaalt. Eestist osalevad Nikolai Kormašov, Olav Maran, Tauno Kangro, Slava Semerikov, Vladimir Anšon, Sergei Inkatov, Sergei Minin ja teised

  5. Ähvardus : olümpiamängude teleülekanne jääb ära / Kai Kalamees

    Index Scriptorium Estoniae

    Kalamees, Kai

    2005-01-01

    Riigikogu liige Jaak Allik peab vajalikuks leida ETV-le lisamiljoneid olümpiamängude ja jalgpalli MM-i teleülekanneteks. Riigikogu liikmed Olav Aarna ja Katrin Saks kritiseerisid valitsust, et rahvusringhäälingu arengukava suhtes pole võetud seisukohta. Kultuuriminister Raivo Palmaru arvamusi. Lisa: Ringhäälingureform tulekul

  6. Disability and Adult Life: Dependence on Social Security among Former Students with Special Educational Needs in Their Late Twenties

    Science.gov (United States)

    Myklebust, Jon Olav

    2013-01-01

    This article, by Jon Olav Myklebust from Volda University, Norway, presents analyses of social security dependence among students with special educational needs in Norway who at the start of upper secondary school had various disabilities--of a somatic, psychological and/or social nature. They were all educated in ordinary schools, in special or…

  7. The Role of Racial Discrimination in the Economic Value of Education Among Urban, Low-Income Latina/o Youth: Ethnic Identity and Gender as Moderators.

    Science.gov (United States)

    Mroczkowski, Alison L; Sánchez, Bernadette

    2015-09-01

    The present study used resilience theory to explore relationships among perceived racial discrimination, ethnic identity, gender, and economic value of education (EVE) among urban, low-income, Latina/o youth. It was expected that racial discrimination would predict poorer perceptions of the EVE among Latina/o adolescents. Ethnic identity was hypothesized to buffer the negative effect of racial discrimination on Latina/o students' EVE. The participants in this study were 396 urban, low-income Latina/o high school students from a large, Midwestern city who completed surveys in both 9th- and 10th-grade. Structural equation modeling was used to test the relationships among racial discrimination, ethnic identity, and EVE. Results supported a protective model of resilience. Specifically, ethnic identity served as a protective factor by buffering the negative effect of perceived racial discrimination on EVE for male participants. The present study is the first to examine ethnic identity as a buffer of racial discrimination on EVE among Latina/o high school students. Future directions and implications are discussed.

  8. Muusika / Saari Tamm

    Index Scriptorium Estoniae

    Tamm, Saari, 1968-

    2005-01-01

    Lühisõnumid: ERSO osales Läänemere festivalil. 18. - 29. VIII toimuvad EMAs suvekursused "Crossing Borders in interpretation of Classical Music and jazz". Konstantin Türnpu 140. 22. - 24. VIII toimub XII Lõuna-Eesti noorte pianistide suvekool. 21. VIII esineb Estonia kontserdisaalis Helsinki Festival Orchestra. 20. VIII toimub Tartu laululaval Olav Ehala loomingu galakontsert

  9. Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.

    Directory of Open Access Journals (Sweden)

    Che-Yu Chu

    Full Text Available BACKGROUND: Obesity is a complex, multifactorial disorder influenced by the interaction of genetic, epigenetic, and environmental factors. Obesity increases the risk of contracting many chronic diseases or metabolic syndrome. Researchers have established several mammalian models of obesity to study its underlying mechanism. However, a lower vertebrate model for conveniently performing drug screening against obesity remains elusive. The specific aim of this study was to create a zebrafish obesity model by over expressing the insulin signaling hub of the Akt1 gene. METHODOLOGY/PRINCIPAL FINDINGS: Skin oncogenic transformation screening shows that a stable zebrafish transgenic of Tg(krt4Hsa.myrAkt1(cy18 displays severely obese phenotypes at the adult stage. In Tg(krt4:Hsa.myrAkt1(cy18, the expression of exogenous human constitutively active Akt1 (myrAkt1 can activate endogenous downstream targets of mTOR, GSK-3α/β, and 70S6K. During the embryonic to larval transitory phase, the specific over expression of myrAkt1 in skin can promote hypertrophic and hyperplastic growth. From 21 hour post-fertilization (hpf onwards, myrAkt1 transgene was ectopically expressed in several mesenchymal derived tissues. This may be the result of the integration position effect. Tg(krt4:Hsa.myrAkt1(cy18 caused a rapid increase of body weight, hyperplastic growth of adipocytes, abnormal accumulation of fat tissues, and blood glucose intolerance at the adult stage. Real-time RT-PCR analysis showed the majority of key genes on regulating adipogenesis, adipocytokine, and inflammation are highly upregulated in Tg(krt4:Hsa.myrAkt1(cy18. In contrast, the myogenesis- and skeletogenesis-related gene transcripts are significantly downregulated in Tg(krt4:Hsa.myrAkt1(cy18, suggesting that excess adipocyte differentiation occurs at the expense of other mesenchymal derived tissues. CONCLUSION/SIGNIFICANCE: Collectively, the findings of this study provide direct evidence that Akt1

  10. Up-regulation of Hsp72 and keratin16 mediates wound healing in streptozotocin diabetic rats

    Directory of Open Access Journals (Sweden)

    Rasha R. Ahmed

    2015-01-01

    Full Text Available BACKGROUND: Impaired wound healing is a complication of diabetes and a serious problem in clinical practice. We previously found that whey protein (WP was able to regulate wound healing normally in streptozotocin (STZ-dia-betic models. This subsequent study was designed to assess the effect of WP on heat shock protein-72 (Hsp72 and keratin16 (Krt16 expression during wound healing in diabetic rats. METHODS: WP at a dosage of 100 mg/kg of body weight was orally administered daily to wounded normal and STZ-diabetic rats for 8 days. RESULTS: At day 4, the WP-treated diabetic wound was significantly reduced compared to that in the corresponding control. Diabetic wounded rats developed severe inflammatory infiltration and moderate capillary dilatation and regeneration. Treated rats had mild necrotic formation, moderate infiltration, moderate to severe capillary dilatation and regeneration, in addition to moderate epidermal formation. Hsp72 and Krt16 densities showed low and dense activity in diabetic wounded and diabetic wounded treated groups, respectively. At day 8, WP-treatment of diabetic wounded animals revealed great amelioration with complete recovery and closure of the wound. Reactivity of Hsp72 and Krt16 was reversed, showing dense and low, or medium and low, activity in the diabetic wounded and diabetic wounded treated groups, respectively. Hsp72 expression in the pancreas was found to show dense reactivity with WP-treated diabetic wound rats. CONCLUSION: This data provides evidence for the potential impact of WP in the up-regulation of Hsp72 and Krt16 in T1D, resulting in an improved wound healing process in diabetic models.

  11. Grieg: Works for String Orchestra. Gothenburg Symphony Orchestra, Neeme Järvi / Sanders, Alan

    Index Scriptorium Estoniae

    Sanders, Alan

    1993-01-01

    Uuest heliplaadist "Grieg: Works for String Orchestra. Gothenburg Symphony Orchestra, Neeme Järvi. CD 437 520 - 2GH Grieg: Land Sighting, Op.32, Olav Trygvason, Op.50, Per Gynt Suites N1,Op.46, N2,Op.55. Randi Stene, Anne Gjevang, Hakan Hagegard, Gothenburg Symphony Chorus, Gothenburg Symphony Orchestra, Neeme Järvi. CD 437 523 - 2 GH

  12. Sex differences in interactions between nucleus accumbens and visual cortex by explicit visual erotic stimuli: an fMRI study.

    Science.gov (United States)

    Lee, S W; Jeong, B S; Choi, J; Kim, J-W

    2015-01-01

    Men tend to have greater positive responses than women to explicit visual erotic stimuli (EVES). However, it remains unclear, which brain network makes men more sensitive to EVES and which factors contribute to the brain network activity. In this study, we aimed to assess the effect of sex difference on brain connectivity patterns by EVES. We also investigated the association of testosterone with brain connection that showed the effects of sex difference. During functional magnetic resonance imaging scans, 14 males and 14 females were asked to see alternating blocks of pictures that were either erotic or non-erotic. Psychophysiological interaction analysis was performed to investigate the functional connectivity of the nucleus accumbens (NA) as it related to EVES. Men showed significantly greater EVES-specific functional connection between the right NA and the right lateral occipital cortex (LOC). In addition, the right NA and the right LOC network activity was positively correlated with the plasma testosterone level in men. Our results suggest that the reason men are sensitive to EVES is the increased interaction in the visual reward networks, which is modulated by their plasma testosterone level.

  13. Expression of the pair-rule gene homologs runt, Pax3/7, even-skipped-1 and even-skipped-2 during larval and juvenile development of the polychaete annelid Capitella teleta does not support a role in segmentation

    Directory of Open Access Journals (Sweden)

    Seaver Elaine C

    2012-04-01

    Full Text Available Abstract Background Annelids and arthropods each possess a segmented body. Whether this similarity represents an evolutionary convergence or inheritance from a common segmented ancestor is the subject of ongoing investigation. Methods To investigate whether annelids and arthropods share molecular components that control segmentation, we isolated orthologs of the Drosophila melanogaster pair-rule genes, runt, paired (Pax3/7 and eve, from the polychaete annelid Capitella teleta and used whole mount in situ hybridization to characterize their expression patterns. Results When segments first appear, expression of the single C. teleta runt ortholog is only detected in the brain. Later, Ct-runt is expressed in the ventral nerve cord, foregut and hindgut. Analysis of Pax genes in the C. teleta genome reveals the presence of a single Pax3/7 ortholog. Ct-Pax3/7 is initially detected in the mid-body prior to segmentation, but is restricted to two longitudinal bands in the ventral ectoderm. Each of the two C. teleta eve orthologs has a unique and complex expression pattern, although there is partial overlap in several tissues. Prior to and during segment formation, Ct-eve1 and Ct-eve2 are both expressed in the bilaterial pair of mesoteloblasts, while Ct-eve1 is expressed in the descendant mesodermal band cells. At later stages, Ct-eve2 is expressed in the central and peripheral nervous system, and in mesoderm along the dorsal midline. In late stage larvae and adults, Ct-eve1 and Ct-eve2 are expressed in the posterior growth zone. Conclusions C. teleta eve, Pax3/7 and runt homologs all have distinct expression patterns and share expression domains with homologs from other bilaterians. None of the pair-rule orthologs examined in C. teleta exhibit segmental or pair-rule stripes of expression in the ectoderm or mesoderm, consistent with an independent origin of segmentation between annelids and arthropods.

  14. Safety and efficacy of everolimus with exemestane vs. exemestane alone in elderly patients with HER2-negative, hormone receptor-positive breast cancer in BOLERO-2.

    Science.gov (United States)

    Pritchard, Kathleen I; Burris, Howard A; Ito, Yoshinori; Rugo, Hope S; Dakhil, Shaker; Hortobagyi, Gabriel N; Campone, Mario; Csöszi, Tibor; Baselga, José; Puttawibul, Puttisak; Piccart, Martine; Heng, Daniel; Noguchi, Shinzaburo; Srimuninnimit, Vichien; Bourgeois, Hugues; Gonzalez Martin, Antonio; Osborne, Karen; Panneerselvam, Ashok; Taran, Tetiana; Sahmoud, Tarek; Gnant, Michael

    2013-12-01

    Postmenopausal women with hormone receptor-positive (HR(+)) breast cancer in whom disease progresses or there is recurrence while taking a nonsteroidal aromatase inhibitor (NSAI) are usually treated with exemestane (EXE), but no single standard of care exists in this setting. The BOLERO-2 trial demonstrated that adding everolimus (EVE) to EXE improved progression-free survival (PFS) while maintaining quality of life when compared with EXE alone. Because many women with HR(+) advanced breast cancer are elderly, the tolerability profile of EVE plus EXE in this population is of interest. BOLERO-2, a phase III randomized trial, compared EVE (10 mg/d) and placebo (PBO), both plus EXE (25 mg/d), in 724 postmenopausal women with HR(+) advanced breast cancer recurring/progressing after treatment with NSAIs. Safety and efficacy data in elderly patients are reported at 18-month median follow-up. Baseline disease characteristics and treatment histories among the elderly subsets (≥ 65 years, n = 275; ≥ 70 years, n = 164) were generally comparable with younger patients. The addition of EVE to EXE improved PFS regardless of age (hazard ratio, 0.59 [≥ 65 years] and 0.45 [≥ 70 years]). Adverse events (AEs) of special interest (all grades) that occurred more frequently with EVE than with PBO included stomatitis, infections, rash, pneumonitis, and hyperglycemia. Elderly EVE-treated patients had similar incidences of these AEs as did younger patients but had more on-treatment deaths. Adding EVE to EXE offers substantially improved PFS over EXE and was generally well tolerated in elderly patients with HR(+) advanced breast cancer. Careful monitoring and appropriate dose reductions or interruptions for AE management are recommended during treatment with EVE in this patient population. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  15. The Transcriptional Landscape of p53 Signalling Pathway

    Directory of Open Access Journals (Sweden)

    Chizu Tanikawa

    2017-06-01

    Full Text Available Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene. To further elucidate the p53-signalling network, we performed transcriptome analysis on 24 tissues in p53+/+ or p53−/− mice after whole-body X-ray irradiation. Here we found transactivation of a total of 3551 genes in one or more of the 24 tissues only in p53+/+ mice, while 2576 genes were downregulated. p53 mRNA expression level in each tissue was significantly associated with the number of genes upregulated by irradiation. Annotation using TCGA (The Cancer Genome Atlas database revealed that p53 negatively regulated mRNA expression of several cancer therapeutic targets or pathways such as BTK, SYK, and CTLA4 in breast cancer tissues. In addition, stomach exhibited the induction of Krt6, Krt16, and Krt17 as well as loricrin, an epidermal differentiation marker, after the X-ray irradiation only in p53+/+ mice, implying a mechanism to protect damaged tissues by rapid induction of differentiation. Our comprehensive transcriptome analysis elucidated tissue specific roles of p53 and its signalling networks in DNA-damage response that will enhance our understanding of cancer biology.

  16. Teadmistepõhise Eesti poole - miks ja kuidas? / Olav Aarna

    Index Scriptorium Estoniae

    Aarna, Olav, 1942-

    2004-01-01

    Autori sõnul on ühiskonnas kujunemas selge arusaam, et rahvusliku innovatsioonisüsteemi osaks oleval haridussüsteemil on arengumudeli muutmisel täita võtmeroll. Graafik: Eesti arengustsenaariumid. Tabel: Eesti haridusstsenaariumid

  17. Loss of notochordal cell phenotype in 3D-cell cultures: implications for disc physiology and disc repair.

    Science.gov (United States)

    Omlor, G W; Nerlich, A G; Tirlapur, U K; Urban, J P; Guehring, T

    2014-12-01

    Embryonic notochordal disc nucleus cells (NC) have been identified to protect disc tissue against disc degeneration but in human beings NC phenotype gets lost with aging and the pathophysiological mechanisms are poorly understood. NC may stimulate other cells via soluble factors, and NC-conditioned medium can be used to stimulate matrix production of other disc cells and mesenchymal stem cells and thus may be of special interest for biological disc repair. As this stimulatory effect is associated with the NC phenotype, we investigated how cell morphology and gene-expression of the NC phenotype changes with time in 3D-cell culture. NC and inner annulus chondrocyte-like cells (CLC) from immature pigtails (freshly isolated cells/tissue, 3D-alginate beads, 3D-clusters) were cultured for up to 16 days under normoxia and hypoxia. Protein-expression was analysed by immunohistology and gene-expression analysis was carried out on freshly isolated cells and cultured cells. Cell morphology and proliferation were analysed by two-photon-laser-microscopy. Two-photon-laser-microscopy showed a homogenous and small CLC population in the inner annulus, which differed from the large vacuole-containing NC in the nucleus. Immunohistology found 93 % KRT8 positive cells in the nucleus and intracellular and pericellular Col2, IL6, and IL12 staining while CLC were KRT8 negative. Freshly isolated NC showed significantly higher KRT8 and CAIII but lower Col2 gene-expression than CLC. NC in 3D-cultures demonstrated significant size reduction and loss of vacuoles with culture time, all indicating a loss of the characteristic NC morphology. Hypoxia reduced the rate of decrease in NC size and vacuoles. Gene-expression of KRT8 and CAIII in NC fell significantly early in culture while Col2 did not decrease significantly within the culture period. In CLC, KRT8 and CAIII gene-expression was low and did not change noticeably in culture, whereas Col2 expression fell with time in culture. 3D

  18. Endogenous Retrovirus 3 – History, Physiology, and Pathology

    Science.gov (United States)

    Bustamante Rivera, Yomara Y.; Brütting, Christine; Schmidt, Caroline; Volkmer, Ines; Staege, Martin S.

    2018-01-01

    Endogenous viral elements (EVE) seem to be present in all eukaryotic genomes. The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3) is one of these elements that is present only in humans and other Catarrhini. Conservation of ERV3 in most of the investigated Catarrhini and the expression pattern in normal tissues suggest a putative physiological role of ERV3. On the other hand, ERV3 has been implicated in the pathogenesis of auto-immunity and cancer. In the present review we summarize knowledge about this interesting EVE. We propose the model that expression of ERV3 (and probably other EVE loci) under pathological conditions might be part of a metazoan SOS response. PMID:29379485

  19. Extended analysis of the Trojan-horse attack in quantum key distribution

    Science.gov (United States)

    Vinay, Scott E.; Kok, Pieter

    2018-04-01

    The discrete-variable quantum key distribution protocols based on the 1984 protocol of Bennett and Brassard (BB84) are known to be secure against an eavesdropper, Eve, intercepting the flying qubits and performing any quantum operation on them. However, these protocols may still be vulnerable to side-channel attacks. We investigate the Trojan-horse side-channel attack where Eve sends her own state into Alice's apparatus and measures the reflected state to estimate the key. We prove that the separable coherent state is optimal for Eve among the class of multimode Gaussian attack states, even in the presence of thermal noise. We then provide a bound on the secret key rate in the case where Eve may use any separable state.

  20. Endogenous Retrovirus 3 – History, Physiology, and Pathology

    Directory of Open Access Journals (Sweden)

    Yomara Y. Bustamante Rivera

    2018-01-01

    Full Text Available Endogenous viral elements (EVE seem to be present in all eukaryotic genomes. The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3 is one of these elements that is present only in humans and other Catarrhini. Conservation of ERV3 in most of the investigated Catarrhini and the expression pattern in normal tissues suggest a putative physiological role of ERV3. On the other hand, ERV3 has been implicated in the pathogenesis of auto-immunity and cancer. In the present review we summarize knowledge about this interesting EVE. We propose the model that expression of ERV3 (and probably other EVE loci under pathological conditions might be part of a metazoan SOS response.

  1. Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study).

    Science.gov (United States)

    Zazzi, M; Kaiser, R; Sönnerborg, A; Struck, D; Altmann, A; Prosperi, M; Rosen-Zvi, M; Petroczi, A; Peres, Y; Schülter, E; Boucher, C A; Brun-Vezinet, F; Harrigan, P R; Morris, L; Obermeier, M; Perno, C-F; Phanuphak, P; Pillay, D; Shafer, R W; Vandamme, A-M; van Laethem, K; Wensing, A M J; Lengauer, T; Incardona, F

    2011-04-01

    The EuResist expert system is a novel data-driven online system for computing the probability of 8-week success for any given pair of HIV-1 genotype and combination antiretroviral therapy regimen plus optional patient information. The objective of this study was to compare the EuResist system vs. human experts (EVE) for the ability to predict response to treatment. The EuResist system was compared with 10 HIV-1 drug resistance experts for the ability to predict 8-week response to 25 treatment cases derived from the EuResist database validation data set. All current and past patient data were made available to simulate clinical practice. The experts were asked to provide a qualitative and quantitative estimate of the probability of treatment success. There were 15 treatment successes and 10 treatment failures. In the classification task, the number of mislabelled cases was six for EuResist and 6-13 for the human experts [mean±standard deviation (SD) 9.1±1.9]. The accuracy of EuResist was higher than the average for the experts (0.76 vs. 0.64, respectively). The quantitative estimates computed by EuResist were significantly correlated (Pearson r=0.695, Pexperts. However, the agreement among experts was only moderate (for the classification task, inter-rater κ=0.355; for the quantitative estimation, mean±SD coefficient of variation=55.9±22.4%). With this limited data set, the EuResist engine performed comparably to or better than human experts. The system warrants further investigation as a treatment-decision support tool in clinical practice. © 2010 British HIV Association.

  2. Everolimus plus exemestane as first-line therapy in HR⁺, HER2⁻ advanced breast cancer in BOLERO-2.

    Science.gov (United States)

    Beck, J Thaddeus; Hortobagyi, Gabriel N; Campone, Mario; Lebrun, Fabienne; Deleu, Ines; Rugo, Hope S; Pistilli, Barbara; Masuda, Norikazu; Hart, Lowell; Melichar, Bohuslav; Dakhil, Shaker; Geberth, Matthias; Nunzi, Martina; Heng, Daniel Y C; Brechenmacher, Thomas; El-Hashimy, Mona; Douma, Shyanne; Ringeisen, Francois; Piccart, Martine

    2014-02-01

    The present exploratory analysis examined the efficacy, safety, and quality-of-life effects of everolimus (EVE) + exemestane (EXE) in the subgroup of patients in BOLERO-2 whose last treatment before study entry was in the (neo)adjuvant setting. In BOLERO-2, patients with hormone-receptor-positive (HR(+)), human epidermal growth factor receptor-2-negative (HER2(-)) advanced breast cancer recurring/progressing after a nonsteroidal aromatase inhibitor (NSAI) were randomly assigned (2:1) to receive EVE (10 mg/day) + EXE (25 mg/day) or placebo (PBO) + EXE. The primary endpoint was progression-free survival (PFS) by local assessment. Overall, 137 patients received first-line EVE + EXE (n = 100) or PBO + EXE (n = 37). Median PFS by local investigator assessment nearly tripled to 11.5 months with EVE + EXE from 4.1 months with PBO + EXE (hazard ratio = 0.39; 95 % CI 0.25-0.62), while maintaining quality of life. This was confirmed by central assessment (15.2 vs 4.2 months; hazard ratio = 0.32; 95 % CI 0.18-0.57). The marked PFS improvement in patients receiving EVE + EXE as first-line therapy for disease recurrence during or after (neo)adjuvant NSAI therapy supports the efficacy of this combination in the first-line setting. Furthermore, the results highlight the potential benefit of early introduction of EVE + EXE in the management of HR(+), HER2(-) advanced breast cancer in postmenopausal patients.

  3. Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: subgroup analysis from the BOLERO-2 study.

    Science.gov (United States)

    Campone, Mario; Bachelot, Thomas; Gnant, Michael; Deleu, Ines; Rugo, Hope S; Pistilli, Barbara; Noguchi, Shinzaburo; Shtivelband, Mikhail; Pritchard, Kathleen I; Provencher, Louise; Burris, Howard A; Hart, Lowell; Melichar, Bohuslav; Hortobagyi, Gabriel N; Arena, Francis; Baselga, José; Panneerselvam, Ashok; Héniquez, Aurelia; El-Hashimyt, Mona; Taran, Tetiana; Sahmoud, Tarek; Piccart, Martine

    2013-08-01

    Everolimus (EVE; an inhibitor of mammalian target of rapamycin [mTOR]) enhances treatment options for postmenopausal women with hormone-receptor-positive (HR(+)), human epidermal growth factor receptor-2-negative (HER2(-)) advanced breast cancer (ABC) who progress on a non-steroidal aromatase inhibitor (NSAI). This is especially true for patients with visceral disease, which is associated with poor prognosis. The BOLERO-2 (Breast cancer trial of OraLEveROlimus-2) trial showed that combination treatment with EVE and exemestane (EXE) versus placebo (PBO)+EXE prolonged progression-free survival (PFS) by both investigator (7.8 versus 3.2 months, respectively) and independent (11.0 versus 4.1 months, respectively) central assessment in postmenopausal women with HR(+), HER2(-) ABC recurring/progressing during/after NSAI therapy. The BOLERO-2 trial included a substantial proportion of patients with visceral metastases (56%). Prespecified exploratory subgroup analysis conducted to evaluate the efficacy and safety of EVE+EXE versus PBO+EXE in a prospectively defined subgroup of patients with visceral metastases. At a median follow-up of 18 months, EVE+EXE significantly prolonged median PFS compared with PBO+EXE both in patients with visceral metastases (N=406; 6.8 versus 2.8 months) and in those without visceral metastases (N=318; 9.9 versus 4.2 months). Improvements in PFS with EVE+EXE versus PBO+EXE were also observed in patients with visceral metastases regardless of Eastern Cooperative Oncology Group performance status (ECOG PS). Patients with visceral metastases and ECOG PS 0 had a median PFS of 6.8 months with EVE+EXE versus 2.8 months with PBO+EXE. Among patients with visceral metastases and ECOG PS ≥1, EVE+EXE treatment more than tripled median PFS compared with PBO+EXE (6.8 versus 1.5 months). Adding EVE to EXE markedly extended PFS by ≥4 months among patients with HR(+) HER2(-) ABC regardless of the presence of visceral metastases. Copyright © 2013 The

  4. Parvovirus-derived endogenous viral elements in two South American rodent genomes.

    Science.gov (United States)

    Arriagada, Gloria; Gifford, Robert J

    2014-10-01

    We describe endogenous viral elements (EVEs) derived from parvoviruses (family Parvoviridae) in the genomes of the long-tailed chinchilla (Chinchilla lanigera) and the degu (Octodon degus). The novel EVEs include dependovirus-related elements and representatives of a clearly distinct parvovirus lineage that also has endogenous representatives in marsupial genomes. In the degu, one dependovirus-derived EVE was found to carry an intact reading frame and was differentially expressed in vivo, with increased expression in the liver. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  5. Victims of stalking in India: A study of girl college students in Tirunelveli City

    OpenAIRE

    Jaishankar Karuppannan; Kosalai Puthisigamani

    2007-01-01

    The word 'stalking' was not commonly known in India, until Priyadharshini Mattoo's case (1996) hit the headlines. Eve teasing, a colloquial word for gender harassment is popularly known and Tamil Nadu Prohibition of Eve-Teasing Act, 1998 on that was developed after the brutal killing of a girl named Sarika Shah in Chennai. Though, stalking is there in the past, it was not acknowledged with this terminology and it was always merged with Eve teasing. On the other hand, stalking is much graver t...

  6. Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution.

    Science.gov (United States)

    Hu, Wen-Yang; Hu, Dan-Ping; Xie, Lishi; Li, Ye; Majumdar, Shyama; Nonn, Larisa; Hu, Hong; Shioda, Toshi; Prins, Gail S

    2017-08-01

    Using primary cultures of normal human prostate epithelial cells, we developed a novel prostasphere-based, label-retention assay that permits identification and isolation of stem cells at a single cell level. Their bona fide stem cell nature was corroborated using in vitro and in vivo regenerative assays and documentation of symmetric/asymmetric division. Robust WNT10B and KRT13 levels without E-cadherin or KRT14 staining distinguished individual stem cells from daughter progenitors in spheroids. Following FACS to isolate label-retaining stem cells from label-free progenitors, RNA-seq identified unique gene signatures for the separate populations which may serve as useful biomarkers. Knockdown of KRT13 or PRAC1 reduced sphere formation and symmetric self-renewal highlighting their role in stem cell maintenance. Pathways analysis identified ribosome biogenesis and membrane estrogen-receptor signaling enriched in stem cells with NF-ĸB signaling enriched in progenitors; activities that were biologically confirmed. Further, bioassays identified heightened autophagy flux and reduced metabolism in stem cells relative to progenitors. These approaches similarly identified stem-like cells from prostate cancer specimens and prostate, breast and colon cancer cell lines suggesting wide applicability. Together, the present studies isolate and identify unique characteristics of normal human prostate stem cells and uncover processes that maintain stem cell homeostasis in the prostate gland. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  7. Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution

    Directory of Open Access Journals (Sweden)

    Wen-Yang Hu

    2017-08-01

    Full Text Available Using primary cultures of normal human prostate epithelial cells, we developed a novel prostasphere-based, label-retention assay that permits identification and isolation of stem cells at a single cell level. Their bona fide stem cell nature was corroborated using in vitro and in vivo regenerative assays and documentation of symmetric/asymmetric division. Robust WNT10B and KRT13 levels without E-cadherin or KRT14 staining distinguished individual stem cells from daughter progenitors in spheroids. Following FACS to isolate label-retaining stem cells from label-free progenitors, RNA-seq identified unique gene signatures for the separate populations which may serve as useful biomarkers. Knockdown of KRT13 or PRAC1 reduced sphere formation and symmetric self-renewal highlighting their role in stem cell maintenance. Pathways analysis identified ribosome biogenesis and membrane estrogen-receptor signaling enriched in stem cells with NF-ĸB signaling enriched in progenitors; activities that were biologically confirmed. Further, bioassays identified heightened autophagy flux and reduced metabolism in stem cells relative to progenitors. These approaches similarly identified stem-like cells from prostate cancer specimens and prostate, breast and colon cancer cell lines suggesting wide applicability. Together, the present studies isolate and identify unique characteristics of normal human prostate stem cells and uncover processes that maintain stem cell homeostasis in the prostate gland.

  8. Endovascular Embolization of Bronchial Artery Originating from the Upper Portion of Aortic Arch in Patients with Massive Hemoptysis

    International Nuclear Information System (INIS)

    Jiang, Sen; Sun, Xi-Wen; Yu, Dong; Jie, Bing

    2014-01-01

    PurposeOur experience with endovascular embolization (EVE) of the bronchial artery (BA) originating from the upper portion of the aortic arch (AA) in six patients is described.MethodsAltogether, 818 patients with hemoptysis underwent multidetector row computed tomography angiography (MDCTA) before EVE or AA angiography during EVE. Aberrant BAs originating from the upper portion of the AA were the source of massive hemoptysis in six patients (0.73 %). MDCT angiograms and/or Digital subtraction angiograms were retrospectively reviewed. Selective catheterization and embolization were performed.ResultsThe ostia of the BAs were located on the superior surface of the AA between the brachiocephalic trunk and left common carotid artery in three patients, the junction of the aorta and medial surface of the left subclavian artery in two, and the posterior wall of the upper portion of the AA in one. The six BAs comprised two common trunks, three single right sides, and one single left side. The targeted vessels were successfully catheterized and embolized by a coaxial microcatheter system using polyvinyl alcohol particles. Other pathologic BAs and nonbronchial systemic arteries also were embolized. Bleeding was immediately controlled in all patients with no recurrence of hemoptysis. No procedure-related complications occurred.ConclusionsApplication of EVE of anomalous origin of BAs in patients with hemoptysis is important, as demonstrated in the six reported patients. MDCTA before EVE or AA angiography during EVE is critical to avoid missing a rare aberrant BA originating from the upper portion of the AA

  9. Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate.

    Science.gov (United States)

    Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H; Carrero, Juan Jesus; Djurdjev, Ognjenka; Heerspink, Hiddo J L; Ho, Kevin; Ito, Sadayoshi; Marks, Angharad; Naimark, David; Nash, Danielle M; Navaneethan, Sankar D; Sarnak, Mark; Stengel, Benedicte; Visseren, Frank L J; Wang, Angela Yee-Moon; Köttgen, Anna; Levey, Andrew S; Woodward, Mark; Eckardt, Kai-Uwe; Hemmelgarn, Brenda; Coresh, Josef

    2018-03-24

    Patients with chronic kidney disease and severely decreased glomerular filtration rate (GFR) are at high risk for kidney failure, cardiovascular disease (CVD) and death. Accurate estimates of risk and timing of these clinical outcomes could guide patient counseling and therapy. Therefore, we developed models using data of 264,296 individuals in 30 countries participating in the international Chronic Kidney Disease Prognosis Consortium with estimated GFR (eGFR)s under 30 ml/min/1.73m 2 . Median participant eGFR and urine albumin-to-creatinine ratio were 24 ml/min/1.73m 2 and 168 mg/g, respectively. Using competing-risk regression, random-effect meta-analysis, and Markov processes with Monte Carlo simulations, we developed two- and four-year models of the probability and timing of kidney failure requiring kidney replacement therapy (KRT), a non-fatal CVD event, and death according to age, sex, race, eGFR, albumin-to-creatinine ratio, systolic blood pressure, smoking status, diabetes mellitus, and history of CVD. Hypothetically applied to a 60-year-old white male with a history of CVD, a systolic blood pressure of 140 mmHg, an eGFR of 25 ml/min/1.73m 2 and a urine albumin-to-creatinine ratio of 1000 mg/g, the four-year model predicted a 17% chance of survival after KRT, a 17% chance of survival after a CVD event, a 4% chance of survival after both, and a 28% chance of death (9% as a first event, and 19% after another CVD event or KRT). Risk predictions for KRT showed good overall agreement with the published kidney failure risk equation, and both models were well calibrated with observed risk. Thus, commonly-measured clinical characteristics can predict the timing and occurrence of clinical outcomes in patients with severely decreased GFR. Copyright © 2018 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  10. Premaxillary hyperdontia in medieval Norwegians: a radiographic study.

    Science.gov (United States)

    Stermer Beyer-Olsen, E M

    1989-11-01

    An excavation of a part of the graveyard of St Olav's church, Trondheim, Norway, uncovered 389 tombs from the medieval period (1100-1600). Radiographic examination of 140 skulls with an intact premaxilla revealed hyperdontia in the form of a mesiodens in two (1.4%) cases. This is within the same range as similar medieval and present Nordic populations. Change in functional pattern does not seem to influence the prevalence.

  11. Official holidays in 2011

    CERN Multimedia

    HR Department

    2011-01-01

    (Application of Article R II 4.39 of the Staff Regulations) Official holidays in 2011 (in addition to the special leave during the annual closure): Saturday 1 January\t(New Year) Friday 22 April\t(Good Friday) Monday 25 April\t(Easter Monday) Sunday 1 May Thursday 2 June\t(Ascension day) Friday 3 June\t(compensation granted for 1 May) Monday 13 June\t(Whit Monday) Thursday 8 September\t(“Jeûne genevois”)  Thursday 22 December\t(compensation granted for 24 December, Christmas Eve) Friday 23 December\t(compensation granted for 25 December, Christmas) Saturday 24 December\t(Christmas Eve) Sunday 25 December\t(Christmas) Thursday 29 December\t(compensation granted for 31 December, New Year’s Eve) Friday 30 December\t(compensation granted for 1 January 2012, New Year) Saturday 31 December\t(New Year’s Eve) Tel. 73903

  12. Effect of external volume expansion on the survival of fat grafts

    Directory of Open Access Journals (Sweden)

    Raghuveer Reddy

    2016-01-01

    Full Text Available Introduction: External volume expansion (EVE is one method, which has been utilised for increasing the survival of adipose tissue grafts. EVE releases positive pressure from the graft and also induces intense levels of edema that decreases diffusion of metabolites essential for graft survival initially. The ideal timing of external volume expansion in relation to the injection of the fat to facilitate survival is not yet clear. Aims and Objectives: This study was undertaken to evaluate and compare the efficacy of external volume expansion applied at variable time points in relation to the injection of the fat. Materials and Methods: Athymic mouse was the animal model and human lipo-aspirate mixed with PRP was used as graft. An indigenous dome shaped silicone device was fabricated to deliver a negative pressure of -30 mm of Hg. The EVE was applied at variable time intervals. At the end of 4 weeks visual, histological and radiological features of the injected fat were compared. The adipose tissue was stained with human vimentin to ascertain the origin of the retained fat. Results: All the grafts, which had EVE, had significantly better volume retention and vascularity. The groups which underwent a delayed EVE or prior expansion followed by concomitant graft injection and expansion showed the most optimal vascularity and graft retention. Conclusions: A delayed EVE or prior expansion followed by concomitant graft injection and expansion may be the most ideal combinations to optimize graft take. However, on account of the relatively small sample size, there was a limitation in drawing statistically significant conclusions for certain variables.

  13. Genetics Home Reference: Dowling-Degos disease

    Science.gov (United States)

    ... can be triggered by UV light, sweating, or friction on the skin. The pigmentation changes characteristic of ... A, Ruzicka T, Betz RC, Hanneken S. The First Report of KRT5 Mutation Underlying Acantholytic Dowling-Degos Disease ...

  14. Genetic and bibliographic information: KRT5 [GenLibi

    Lifescience Database Archive (English)

    Full Text Available nd Neonatal Diseases and Abnormalities (C16) > Congenital Abnormalities (C16.131) > Skin Abnormalities (C16....ases, Inborn (C16.320) > Skin Diseases, Genetic (C16.320.850) > Epidermolysis Bullosa (C16.320.850.275) > Ep...idermolysis Bullosa Simplex (C16.320.850.275.180) Skin and Connective Tissue Diseases (C17) > Skin Diseases (C17.800) > Skin....493) > Epidermolysis Bullosa Simplex (C17.800.804.493.180) Skin and Connective Tissue Diseases (C17) > Skin Diseases (C17.800) > Ski...rmolysis Bullosa Simplex (C17.800.827.275.180) Skin and Connective Tissue Diseases (C17) > Skin

  15. Financialised capitalism Soviet style? Varieties of state capture and crisis

    NARCIS (Netherlands)

    Visser, A.; Kalb, D.P.

    2010-01-01

    Looking for new ways to interpret the failings of the neo-liberal economy, this article argues that financialised capitalism at the eve of the 2008 financial crisis showed striking analogies with the characteristic combination of oligopoly and informality of the Soviet economy at the eve of its

  16. Kas käitumishinne või kirjalik iseloomustus / Olav Kruus

    Index Scriptorium Estoniae

    Kruus, Olav

    2000-01-01

    29. sept.̀2000 toimus Haridusministeeriumis Õppurite Nõukogu istung, kus oli arutusel käitumishinde asendamine kirjaliku iseloomustusega, rahvusvahelise õpilaspileti ISIC Scholar kasutuselevõtmine ja Õppurite Nõukogu uute liikmete määramine

  17. Applications of the Galton-Watson process to human DNA evolution and demography

    CERN Document Server

    Neves, A G M

    2005-01-01

    We show that the problem of existence of a mitochondrial Eve can be understood as an application of the Galton--Watson process and presents interesting analogies with critical phenomena in Statistical Mechanics. In the approximation of small survival probability, and assuming limited progeny, we are able to find for a genealogic tree the maximum and minimum survival probabilities over all probability distributions for the number of children per woman constrained to a given mean. As a consequence, we can relate existence of a mitochondrial Eve to quantitative demographic data of early mankind. In particular, we show that a mitochondrial Eve may exist even in an exponentially growing population, provided that the mean number of children per woman $\\overline N$ is constrained to a small range depending on the probability $p$ that a child is a female. Assuming that the value $p \\approx 0.488$ valid nowadays has remained fixed for thousands of generations, the range where a mitochondrial Eve occurs with sizeable p...

  18. Portable electronic vision enhancement systems in comparison with optical magnifiers for near vision activities: an economic evaluation alongside a randomized crossover trial.

    Science.gov (United States)

    Bray, Nathan; Brand, Andrew; Taylor, John; Hoare, Zoe; Dickinson, Christine; Edwards, Rhiannon T

    2017-08-01

    To determine the incremental cost-effectiveness of portable electronic vision enhancement system (p-EVES) devices compared with optical low vision aids (LVAs), for improving near vision visual function, quality of life and well-being of people with a visual impairment. An AB/BA randomized crossover trial design was used. Eighty-two participants completed the study. Participants were current users of optical LVAs who had not tried a p-EVES device before and had a stable visual impairment. The trial intervention was the addition of a p-EVES device to the participant's existing optical LVA(s) for 2 months, and the control intervention was optical LVA use only, for 2 months. Cost-effectiveness and cost-utility analyses were conducted from a societal perspective. The mean cost of the p-EVES intervention was £448. Carer costs were £30 (4.46 hr) less for the p-EVES intervention compared with the LVA only control. The mean difference in total costs was £417. Bootstrapping gave an incremental cost-effectiveness ratio (ICER) of £736 (95% CI £481 to £1525) for a 7% improvement in near vision visual function. Cost per quality-adjusted life year (QALY) ranged from £56 991 (lower 95% CI = £19 801) to £66 490 (lower 95% CI = £23 055). Sensitivity analysis varying the commercial price of the p-EVES device reduced ICERs by up to 75%, with cost per QALYs falling below £30 000. Portable electronic vision enhancement system (p-EVES) devices are likely to be a cost-effective use of healthcare resources for improving near vision visual function, but this does not translate into cost-effective improvements in quality of life, capability or well-being. © 2016 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation and European Association for Vision & Eye Research.

  19. Erythrodermia Congenitalis Ichthyosiformis Bullosa of Brocq

    Directory of Open Access Journals (Sweden)

    Dorothea Sander

    2016-01-01

    Full Text Available A 50-year-old man presented with congenital scaling and hyperkeratosis on his palms, the soles of his feet and the extensor areas of his joints. The flexural areas were unaffected. His maternal grandmother, questionably his maternal uncle, his mother, all three brothers, one of his two sisters as well as two nephews and three nieces have or had similar skin changes. A punch biopsy was taken from the left palm. Clinical and histological signs led to the diagnosis of erythrodermia congenitalis ichthyosiformis bullosa of Brocq. We confirmed this genetically and found a heterozygous duplication (c.1752dupT in the keratin 1 gene (KRT-1. To our knowledge, this is the first case of this skin condition reported in the literature with a heterozygous duplication (c.1752dupT in KRT-1.

  20. The Sovereign Citizen Movement: The Shifting Ideological Winds

    Science.gov (United States)

    2016-03-01

    theology asserts that Eve had sex with the devil and Adam on the same day.52 In this theology, the offspring of Adam and Eve produced an Aryan...diminished. White kids flocked to purchase Michael Jordan jerseys and America’s pastime was well integrated. Black singers, artists, writers, and

  1. HOTEL INFORMATION

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Park Plaza Beijing Wangfujing Christmas Eve Celebration at Bloo restaurant on December 24,17:30 p.m.-10:30 p.m.Christmas Eve Dinner Buffet:Indulge in a lavish seafood buffet and international cuisine stations. Groove to live jazz and pop music as you try to win attractive lucky

  2. Clinical application of 64 multi-slice CT angiography for the follow-up of endovascular stent-graft exclusion

    International Nuclear Information System (INIS)

    Yin Longlin; Chen Jiayuan; Jiang Jin; Yang Zhigang; Li Zhenlin; Sun Jiayu; Zhu Hongmei

    2009-01-01

    Objective: To investigate the clinical applications of 64-MSCTA for the follow-up of endovascular stent-graft exclusion (EVE). Methods: Between Oct 2006 and Feb 2008, forty-four 64-MSCTA examinations were performed in 30 patients with aortic dissection (AD) and 5 patients with abdominal aortic aneurysm (AAA) who underwent EVE. Imaging reconstruction including MPR, MIP and VR were finished on workstation. The outcomes and complications after EVE of aortic dissection and aortic aneurysm were evaluated. Results: (1) Of 30 patients with aortic dissection, large thrombosis in false lumen was observed in 28 cases and small thrombosis in 2 cases. The cavity of aortic aneurysm outside the stent was thrombosed completely in 5 patients with AAA. (2) Thrombosis in the innominate artery on follow-up CTA after EVE was found in 1 AD patient with the innominate artery involved, Thrombosis in the superior mesenteric artery was observed on 15 days follow-up CTA but thrombolysis on 3 months after EVE in 1 case, Intimal tear in right common iliac artery was found in 1 case. Of 5 patients with AAA, occlusion of right inner iliac artery was observed in 1 case, and instent thrombosis in distal right common iliac artery was found in 1 case. (3) Endoleak was found in 14 patients with AD, including 8 with type I and 6 with type III endoleaks, one type III endoleak was disappeared on follow-up CTA after 3 months. Conclusions: 64-MSCTA with fast, non-invasive and effective merits, combining multiple reconstructive methods, has become one of preferred imaging methods in post-operative evaluation of EVE. (authors)

  3. Quantum authentication based on the randomness of measurement bases in BB84

    International Nuclear Information System (INIS)

    Dang Minh Dung; Bellot, P.; Alleaume, R.

    2005-01-01

    Full text: The establishment of a secret key between two legitimate end points of a communication link, let us name them Alice and Bob, using Quantum key distribution (QKD) is unconditionally secure thanks to Quantum Physics laws.However, the various QKD protocols do not intend to provide the authentication of the end points: Alice cannot be sure that she is communicating with Bob and reciprocally. Therefore, these protocols are subjects to various attacks. The most obvious attack is the man-in-the-middle attack in which an eavesdropper, let us name her Eve, stands in the middle of the communication link. Alice communicates with Eve meanwhile she thinks she communicate with Bob. And Bob communicates with Eve meanwhile he thinks he is communicating with Alice. Eve, acting as a relay, can read all the communications between Alice and Bob and retransmit them. To prevent this kind of attack, the solution is to authenticate the two end points of the communication link. One solution is that Alice and Bob share an authentication key prior to the communication. In order to improve the security, Alice and Bob must share a set of authentication one-time keys. One-time key means that the key has to be used only once because each time a key is used, the eavesdropper Eve can gain a few information on the key. Re-using the same key many times would finally reveal the key to Eve. However, Eve can simulate many times the authentication process with Alice. Each time Eve simulates the authentication process, one of the pre-positioned keys is depleted leading to the exhaustion of the set of pre-positioned keys. This type of attack is named Denial of Service attack. In this work, we propose to use the randomness of the measurement bases in BB84 to build an authentication scheme based on the existence of a prepositioned authentication key. This authentication scheme can be used with BB84 but also with any other Quantum Key Distribution protocols. It is protected against the Denial of

  4. Educational Virtual Environments as a Lens for Understanding both Precise Repeatability and Specific Variation in Learning Ecologies

    Science.gov (United States)

    Zuiker, Steven J.

    2012-01-01

    As a global cyberinfrastructure, the Internet makes authentic digital problem spaces like educational virtual environments (EVEs) available to a wide range of classrooms, schools and education systems operating under different circumstantial, practical, social and cultural conditions. And yet, if the makers and users of EVEs both have a hand in…

  5. Mutations in POGLUT1, Encoding Protein O-Glucosyltransferase 1, Cause Autosomal-Dominant Dowling-Degos Disease

    DEFF Research Database (Denmark)

    Basmanav, F Buket; Oprisoreanu, Ana-Maria; Pasternack, Sandra M

    2014-01-01

    Dowling-Degos disease (DDD) is an autosomal-dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation. We previously identified loss-of-function mutations in KRT5 but were only able to detect pathogenic mutations in fewer than half of our subjects. To ident...

  6. "Asumi" nurgalahendus tänapäeval = Corner solution of "Asum" today / Roman Koolmar

    Index Scriptorium Estoniae

    Koolmar, Roman, 1904-1971

    2015-01-01

    1937. a. projekteeritud Teedeministeeriumi ametnike korteriühing "Ühiskodu" ja kohtunike korteriühing "Asum" Raua põik 3 ja 5. Välisvaade tänavalt ja sisehoovist. Korruse plaanid. Lk. 65 "Ühiskodu" I korrusel, krt. 2 elanud Koolmarite korteri kaminanurk

  7. Efficacy of everolimus with exemestane versus exemestane alone in Asian patients with HER2-negative, hormone-receptor-positive breast cancer in BOLERO-2.

    Science.gov (United States)

    Noguchi, Shinzaburo; Masuda, Norikazu; Iwata, Hiroji; Mukai, Hirofumi; Horiguchi, Jun; Puttawibul, Puttisak; Srimuninnimit, Vichien; Tokuda, Yutaka; Kuroi, Katsumasa; Iwase, Hirotaka; Inaji, Hideo; Ohsumi, Shozo; Noh, Woo-Chul; Nakayama, Takahiro; Ohno, Shinji; Rai, Yoshiaki; Park, Byeong-Woo; Panneerselvam, Ashok; El-Hashimy, Mona; Taran, Tetiana; Sahmoud, Tarek; Ito, Yoshinori

    2014-11-01

    The addition of mTOR inhibitor everolimus (EVE) to exemestane (EXE) was evaluated in an international, phase 3 study (BOLERO-2) in patients with hormone-receptor-positive (HR(+)) breast cancer refractory to letrozole or anastrozole. The safety and efficacy of anticancer treatments may be influenced by ethnicity (Sekine et al. in Br J Cancer 99:1757-62, 2008). Safety and efficacy results from Asian versus non-Asian patients in BOLERO-2 are reported. Patients were randomized (2:1) to 10 mg/day EVE + EXE or placebo (PBO) + EXE. Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival, response rate, clinical benefit rate, and safety. Of 143 Asian patients, 98 received EVE + EXE and 45 received PBO + EXE. Treatment with EVE + EXE significantly improved median PFS versus PBO + EXE among Asian patients by 38 % (HR = 0.62; 95 % CI, 0.41-0.94). Median PFS was also improved among non-Asian patients by 59 % (HR = 0.41; 95 % CI, 0.33-0.50). Median PFS duration among EVE-treated Asian patients was 8.48 versus 4.14 months for PBO + EXE, and 7.33 versus 2.83 months, respectively, in non-Asian patients. The most common grade 3/4 adverse events (stomatitis, anemia, elevated liver enzymes, hyperglycemia, and dyspnea) occurred at similar frequencies in Asian and non-Asian patients. Grade 1/2 interstitial lung disease occurred more frequently in Asian patients. Quality of life was similar between treatment arms in Asian patients. Adding EVE to EXE provided substantial clinical benefit in both Asian and non-Asian patients with similar safety profiles. This combination represents an improvement in the management of postmenopausal women with HR(+)/HER2(-) advanced breast cancer progressing on nonsteroidal aromatase inhibitors, regardless of ethnicity.

  8. Eye Movements Behavior While Driving a Car: A Review

    Science.gov (United States)

    1978-10-01

    should be filtered if only the relevant information input is to be inveatigated. -13- The analysis of eye movements bahavior should be consi- dered... volunt rvtlv switch hi , attent on From one eve to the other (e.q. LACK, 19"’). The accomodation of the eve at a greater distance in car Jriving

  9. Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair

    DEFF Research Database (Denmark)

    Vestentoft, Peter Siig; Jelnes, Peter; Andersen, Jesper Bøje

    2013-01-01

    differentially up- or down-modulated (P tier of defense (Agrn, Bgn, Fbn1, Col4a1, Col8a1, Col9a3, Lama5, Lamb1, Lamb2, Itga4, Igtb2, Itgb4, Itgb6, Nid2), and their signal intensities showed a strong or very...... strong correlation with Krt1- 19, a well-established marker of a ductular/HPC reaction. Furthermore, a significant up-modulation and very strong correlation between the transcriptional profiles of Krt1-19 and St14 encoding matriptase, a component of a novel protease system, was found in the second tier...... that laminin, Collagen1a1, agrin and nidogen1 surrounded bile ducts, proliferating cholangiocytes, and HPCs in ductular reactions regardless of the nature of defense. Similarly, matriptase and HAI-1 were expressed in cholangiocytes regardless of the tier of defense, but in the second tier of defense...

  10. Human forniceal region is the stem cell-rich zone of the conjunctival epithelium.

    Science.gov (United States)

    Harun, Mohd Hairul Nizam; Sepian, Siti Norzalehawati; Chua, Kien-Hui; Ropilah, Abd Rahman; Abd Ghafar, Norzana; Che-Hamzah, Jemaima; Bt Hj Idrus, Ruszymah; Annuar, Faridah Hanom

    2013-03-01

    The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelia overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. The self-renewing nature of the conjunctival epithelia makes their long-term survival ultimately dependent on small populations of stem cells. Hence, the objective of this study was to investigate the expression of the stem cell genes Sox2, OCT4, NANOG, Rex1, NES, and ABCG2 in cultured human conjunctival epithelium from different conjunctival zones, namely, the bulbar, palpebral and fornix zones. Three samples were taken from patients with primary pterygium and cataract (age range 56-66 years) who presented to our eye clinic at the UKM Medical Centre. The eye was examined with slit lamp to ensure there was no underlying ocular surface diseases and glaucoma. Conjunctival tissue was taken from patients who underwent a standard cataract or pterygium operation as a primary procedure. Tissues were digested, cultured, and propagated until an adequate number of cells was obtained. Total RNA was extracted and subjected to expression analysis of conjunctival epithelium genes (KRT4, KRT13, KRT19) and stem cell genes (Sox2, OCT4, NANOG, Rex1, NES, ABCG2) by reverse transcriptase-PCR and 2% agarose gel electrophoresis. The expression of Sox2, OCT4, and NANOG genes were detected in the fornical cells, while bulbar cells only expressed Sox2 and palpebral cells only expressed OCT4. Based on these results, the human forniceal region expresses a higher number of stem cell genes than the palpebral and bulbar conjunctiva.

  11. Uncovering the Repertoire of Endogenous Flaviviral Elements in Aedes Mosquito Genomes.

    Science.gov (United States)

    Suzuki, Yasutsugu; Frangeul, Lionel; Dickson, Laura B; Blanc, Hervé; Verdier, Yann; Vinh, Joelle; Lambrechts, Louis; Saleh, Maria-Carla

    2017-08-01

    Endogenous viral elements derived from nonretroviral RNA viruses have been described in various animal genomes. Whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in Aedes mosquitoes, the vectors of arboviruses such as dengue and chikungunya viruses. Previous studies identified three EFVEs from Aedes albopictus cell lines and one from Aedes aegypti cell lines. However, an in-depth characterization of EFVEs in wild-type mosquito populations and individual mosquitoes in vivo has not been performed. We detected the full-length DNA sequence of the previously described EFVEs and their respective transcripts in several A. albopictus and A. aegypti populations from geographically distinct areas. However, EFVE-derived proteins were not detected by mass spectrometry. Using deep sequencing, we detected the production of PIWI-interacting RNA-like small RNAs, in an antisense orientation, targeting the EFVEs and their flanking regions in vivo The EFVEs were integrated in repetitive regions of the mosquito genomes, and their flanking sequences varied among mosquito populations. We bioinformatically predicted several new EFVEs from a Vietnamese A. albopictus population and observed variation in the occurrence of those elements among mosquitoes. Phylogenetic analysis of an A. aegypti EFVE suggested that it integrated prior to the global expansion of the species and subsequently diverged among and within populations. The findings of this study together reveal the substantial structural and nucleotide diversity of flaviviral integrations in Aedes genomes. Unraveling this diversity will help to elucidate the potential biological function of these EFVEs. IMPORTANCE Endogenous viral elements (EVEs) are whole or partial viral sequences integrated in host genomes. Interestingly, some EVEs have important functions for host fitness and

  12. Staff members with 25 years' service at CERN in 2010

    CERN Multimedia

    HR Department

    2010-01-01

    The 38 staff members who are celebrating 25 years at CERN in 2010 were invited by the Director-General to a reception in their honour on 21 October. ASBURY David IT HEGARTY Seamus HR BAUDRENGHIEN Philippe BE ISNARD Christian IT BERGSMA Felix PH JONES Robert IT BERNAL Jean-Manuel TE JOUBERJEAN Franck IT BERRIG Olav Ejner BE LAGRANGE Thierry FP BONT Hillebrand GS MARIN Antonio BE BOURGEOIS Nicolas PH MESENGE Pascal EN BOURREL Thierry EN MISSIAEN Dominique   BE ...

  13. Des personnages érigés en narrateurs : les voix over chez Joseph L. Mankiewicz (A Letter to Three Wives, All about Eve et The Barefoot Contessa

    Directory of Open Access Journals (Sweden)

    Alain Boillat

    2011-08-01

    Full Text Available L’auteur analyse dans une perspective narratologique trois films de Joseph L. Mankiewicz réalisés entre 1949 et 1954 (A Letter to Three Wives, All about Eve et The Barefoot Contessa afin d’observer les particularités qui résultent du recours à un ou plusieurs narrateurs (ou narratrices s’exprimant en voix over. L’accent est mis sur les implications de l’organisation énonciative complexe de ces productions cinématographiques en termes de relation du film au spectateur et de représentation des rapports de genre. Ces études de cas permettent de nuancer certains acquis issus du champ des théories de l’énonciation. Dans ces films où les voix over sont proférées par des acteurs qui incarnent par ailleurs un personnage visualisé, certaines interactions sont observables – interprétées notamment comme des relations de pouvoir – entre le statut des narrateurs et le niveau diégétique. La matérialité sonore est prise en compte dans le cas particulier de Letter to Three Wives, où la voix se transforme en bruit. Cet « effet spécial » est l’occasion de discuter un modèle « impersonnel » de l’énonciation filmique qui intègre, tout en tenant compte de la dimension technologique de l’enregistrement sonore, le pouvoir fondamentalement humanisant des manifestations vocales.

  14. 13C n.m.r. study of solvation mechanisms in the radiation-induced polymerization of vinyl ethers

    International Nuclear Information System (INIS)

    Deffieux, A.; Subira, F.; Stannett, V.T.

    1984-01-01

    A 13 C n.m.r. study of the microstructure of ethyl vinyl ether (EVE) and isopropyl vinyl ether (IPVE) polymers prepared under various experimental conditions and using chemical or γ-ray initiation has been made. Long stereo-sequence assignments were conducted for poly EVE allowing determination of the configurational statistics of propagation in the radiation-induced polymerization of EVE in low polar solvents. Stereo-sequence intensities are found in good agreement with the Markovian model. The results are considered as further support for the occurrence of a specific interaction between the growing active centres and the polymer chains. In the case of IPVE polymers much more important overlappings of the resonance patterns are observed thus preventing any similar detailed study. (author)

  15. Countermeasure against probabilistic blinding attack in practical quantum key distribution systems

    International Nuclear Information System (INIS)

    Qian Yong-Jun; Li Hong-Wei; He De-Yong; Yin Zhen-Qiang; Zhang Chun-Mei; Chen Wei; Wang Shuang; Han Zheng-Fu

    2015-01-01

    In a practical quantum key distribution (QKD) system, imperfect equipment, especially the single-photon detector, can be eavesdropped on by a blinding attack. However, the original blinding attack may be discovered by directly detecting the current. In this paper, we propose a probabilistic blinding attack model, where Eve probabilistically applies a blinding attack without being caught by using only an existing intuitive countermeasure. More precisely, our countermeasure solves the problem of how to define the bound in the limitation of precision of current detection, and then we prove security of the practical system by considering the current parameter. Meanwhile, we discuss the bound of the quantum bit error rate (QBER) introduced by Eve, by which Eve can acquire information without the countermeasure. (paper)

  16. The oncoprotein v-Myb activates transcription of Gremlin 2 during in vitro differentiation of the chicken neural crest to melanoblasts

    Czech Academy of Sciences Publication Activity Database

    Starostová, Michaela; Čermák, Vladimír; Dvořáková, Marta; Karafiát, Vít; Kosla, Jan; Dvořák, Michal

    2014-01-01

    Roč. 540, č. 1 (2014), s. 122-129 ISSN 0378-1119 R&D Projects: GA AV ČR KAN200520801 Institutional support: RVO:68378050 Keywords : Melanocyte development * Tamoxifen-inducible v-Myb * v-Myb-dependent genes * PRDC * KRT19 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.138, year: 2014

  17. Covert Channels and Simple Timed Mix-Firewalls

    National Research Council Canada - National Science Library

    Newman, Richard

    2004-01-01

    .... Initial work considered a simple model where an observer (Eve) was restricted to counting the number of messages leaving a Mix configured as a firewall guarding the enclave with one malicious sender (Alice) and some other naive senders (Clueless's). Here, we consider the case where Eve can distinguish between multiple destinations, and the senders can select to which destination their message (if any) is sent each clock tick.

  18. The Characteristics of Air Pollutants during Two Distinct Episodes of Fireworks Burning in a Valley City of North China.

    Directory of Open Access Journals (Sweden)

    Yang Song

    Full Text Available The elevation and dissipation of pollutants after the ignition of fireworks in different functional areas of a valley city were investigated.The Air Quality Index (AQI as well as inter-day and intra-day concentrations of various air pollutants (PM10, PM2.5, SO2, NO2, CO, O3 were measured during two episodes that took place during Chinese New Year festivities.For the special terrain of Jinan, the mean concentrations of pollutants increased sharply within 2-4 h of the firework displays, and concentrations were 4-6 times higher than the usual levels. It took 2-3 d for the pollutants to dissipate to background levels. Compared to Preliminary Eve (more fireworks are ignited on New Year's Eve, but the amounts of other human activities are also lesser, the primary pollutants PM2.5, PM10, and CO reached higher concentrations on New Year's Eve, and the highest concentrations of these pollutants were detected in living quarters. All areas suffered from serious pollution problems on New Year's Eve (rural = urban for PM10, but rural > urban for PM2.5. However, SO2 and NO2 levels were 20%-60% lower in living quarters and industrial areas compared to the levels in these same areas on Preliminary Eve. In contrast to the other pollutants, O3 concentrations fell instead of rising with the firework displays.Interactions between firework displays and other human activities caused different change trends of pollutants. PM2.5 and PM10 were the main pollutants, and the rural living quarter had some of the highest pollution levels.

  19. Kontsert

    Index Scriptorium Estoniae

    2005-01-01

    Vanemuise kontserdimajas 11. nov. isadepäeva kontserdil "Isad ja pojad" esinemas Olav Ehala ja Tanel Ehala klaveril ja Pärnu Linnaorkester, kaastegev Kiigelaulukuuik (dirigent Erki Pehk). 12. nov. kammerlaval festivalil "Fiesta de la guitarra '05" kitarriduo Katona Twins, 17. nov. Aleksander Rudini ja Tallinna Kammerorkestri kontsert. TÜ aulas 11. nov. kitarrikontsert: Rody van Gemert & Mikko Ikäheimo, 13. nov. "Fiesta de la guitarra '05" pidulik gala. TÜ ajaloo muuseumis 14. nov. Elleri Muusikakooli kontsert "Sügisbarokk". Jaani kirikus 13. nov. festivalil "Fiesta de la guitarra '05" Miguel Rivera ja Luis Carro Barquero

  20. Paradise Lost: Difference between Adam and Eve’s Lament on Leaving Paradise - A Contrastive Analysis

    Directory of Open Access Journals (Sweden)

    Sara Torres Servín

    2013-01-01

    Full Text Available The difference between Adam and Eve’s lament on leaving Paradise in Milton’s Paradise Lost is striking in its contrastive content and depth. This paper analyzes the difference that exists between the feelings and spiritual attitudes that Adam and Eve express on the occasion when they are informed by the angel Michael that they have to abandon the Garden of Eden. It is a comparison of their lament in order to understand the contrast of the two attitudes that Milton wove in the tapestry that Paradise Lost is. The paper also explores male and female roles in Paradise Lost and concludes that Adam and Eve are equal yet different, that difference being the cause of their contrastive ways of expressing their sorrow. Adam and Eve manifest two contrastive worldviews in opposition, one spiritual (heavenly, and the other material (earthly.

  1. Transitional basal cells at the squamous-columnar junction generate Barrett’s oesophagus

    Science.gov (United States)

    Jiang, Ming; Li, Haiyan; Zhang, Yongchun; Yang, Ying; Lu, Rong; Liu, Kuancan; Lin, Sijie; Lan, Xiaopeng; Wang, Haikun; Wu, Han; Zhu, Jian; Zhou, Zhongren; Xu, Jianming; Lee, Dong-Kee; Zhang, Lanjing; Lee, Yuan-Cho; Yuan, Jingsong; Abrams, Julian A.; Wang, Timothy G.; Sepulveda, Antonia R.; Wu, Qi; Chen, Huaiyong; Sun, Xin; She, Junjun; Chen, Xiaoxin; Que, Jianwen

    2017-01-01

    In several organ systems the transitional zone between different types of epithelia is a hotspot for pre-neoplastic metaplasia and malignancy1–3. However, the cell-of-origin for the metaplastic epithelium and subsequent malignancy, remains obscure1–3. In the case of Barrett’s oesophagus (BE), intestinal metaplasia occurs at the gastro-oesophageal junction, where stratified squamous epithelium transitions into simple columnar cells4. Based on different experimental models, several alternative cell types have been proposed as the source of the metaplasia, but in all cases the evidence is inconclusive and no model completely mimics BE with the presence of intestinal goblet cells5–8. Here, we describe a novel transitional columnar epithelium with distinct basal progenitor cells (p63+ KRT5+ KRT7+) in the squamous-columnar junction (SCJ) in the upper gastrointestinal tract of the mouse. We use multiple models and lineage tracing strategies to show that this unique SCJ basal cell population serves as a source of progenitors for the transitional epithelium. Moreover, upon ectopic expression of CDX2 these transitional basal progenitors differentiate into intestinal-like epithelium including goblet cells, thus reproducing Barrett’s metaplasia. A similar transitional columnar epithelium is present at the transitional zones of other mouse tissues, including the anorectal junction, and, importantly, at the gastro-oesophageal junction in the human gut. Acid reflux-induced oesophagitis and the multilayered epithelium (MLE) believed to be a precursor of BE are both characterized by the expansion of the transitional basal progenitor cells. Taken together our findings reveal the presence of a previously unidentified transitional zone in the epithelium of the upper gastrointestinal tract and provide evidence that the p63+ KRT7+ basal cells in this zone are the cell-of-origin for MLE and BE. PMID:29019984

  2. Screening for the Most Suitable Reference Genes for Gene Expression Studies in Equine Milk Somatic Cells.

    Directory of Open Access Journals (Sweden)

    Jakub Cieslak

    Full Text Available Apart from the well-known role of somatic cell count as a parameter reflecting the inflammatory status of the mammary gland, the composition of cells isolated from milk is considered as a valuable material for gene expression studies in mammals. Due to its unique composition, in recent years an increasing interest in mare's milk consumption has been observed. Thus, investigating the genetic background of horse's milk variability presents and interesting study model. Relying on 39 milk samples collected from mares representing three breeds (Polish Primitive Horse, Polish Cold-blooded Horse, Polish Warmblood Horse we aimed to investigate the utility of equine milk somatic cells as a source of mRNA and to screen the best reference genes for RT-qPCR using geNorm and NormFinder algorithms. The results showed that despite relatively low somatic cell counts in mare's milk, the amount and the quality of the extracted RNA are sufficient for gene expression studies. The analysis of the utility of 7 potential reference genes for RT-qPCR experiments for the normalization of equine milk somatic cells revealed some differences between the outcomes of the applied algorithms, although in both cases the KRT8 and TOP2B genes were pointed as the most stable. Analysis by geNorm showed that the combination of 4 reference genes (ACTB, GAPDH, TOP2B and KRT8 is required for apropriate RT-qPCR experiments normalization, whereas NormFinder algorithm pointed the combination of KRT8 and RPS9 genes as the most suitable. The trial study of the relative transcript abundance of the beta-casein gene with the use of various types and numbers of internal control genes confirmed once again that the selection of proper reference gene combinations is crucial for the final results of each real-time PCR experiment.

  3. Proteomic profiling reveals candidate markers for arsenic-induced skin keratosis.

    Science.gov (United States)

    Guo, Zhiling; Hu, Qin; Tian, Jijing; Yan, Li; Jing, Chuanyong; Xie, Heidi Qunhui; Bao, Wenjun; Rice, Robert H; Zhao, Bin; Jiang, Guibin

    2016-11-01

    Proteomics technology is an attractive biomarker candidate discovery tool that can be applied to study large sets of biological molecules. To identify novel biomarkers and molecular targets in arsenic-induced skin lesions, we have determined the protein profile of arsenic-affected human epidermal stratum corneum by shotgun proteomics. Samples of palm and foot sole from healthy subjects were analyzed, demonstrating similar protein patterns in palm and sole. Samples were collected from the palms of subjects with arsenic keratosis (lesional and adjacent non-lesional samples) and arsenic-exposed subjects without lesions (normal). Samples from non-exposed healthy individuals served as controls. We found that three proteins in arsenic-exposed lesional epidermis were consistently distinguishably expressed from the unaffected epidermis. One of these proteins, the cadherin-like transmembrane glycoprotein, desmoglein 1 (DSG1) was suppressed. Down-regulation of DSG1 may lead to reduced cell-cell adhesion, resulting in abnormal epidermal differentiation. The expression of keratin 6c (KRT6C) and fatty acid binding protein 5 (FABP5) were significantly increased. FABP5 is an intracellular lipid chaperone that plays an essential role in fatty acid metabolism in human skin. This raises a possibility that overexpression of FABP5 may affect the proliferation or differentiation of keratinocytes by altering lipid metabolism. KRT6C is a constituent of the cytoskeleton that maintains epidermal integrity and cohesion. Abnormal expression of KRT6C may affect its structural role in the epidermis. Our findings suggest an important approach for future studies of arsenic-mediated toxicity and skin cancer, where certain proteins may represent useful biomarkers of early diagnoses in high-risk populations and hopefully new treatment targets. Further studies are required to understand the biological role of these markers in skin pathogenesis from arsenic exposure. Copyright © 2016 Elsevier Ltd

  4. A Comparison of Gains in Keypad Response Technology Classroom with Other Pedagogies in Nigeria

    Science.gov (United States)

    Agbatogun, Alaba Olaoluwakotansibe

    2013-01-01

    Drawing from the socio-cultural theory of Vygotsky, this study compared the academic performance gains scores of pupils in a Keypad Response Technology (KRT) class with those in two other pedagogies to determine the learners' language proficiency level in ESL classroom. A sample of 99 Nigerian primary six pupils participated in the study.…

  5. Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial.

    Science.gov (United States)

    Lambers Heerspink, Hiddo J; Chertow, Glenn M; Akizawa, Tadao; Audhya, Paul; Bakris, George L; Goldsberry, Angie; Krauth, Melissa; Linde, Peter; McMurray, John J; Meyer, Colin J; Parving, Hans-Henrik; Remuzzi, Giuseppe; Christ-Schmidt, Heidi; Toto, Robert D; Vaziri, Nosratola D; Wanner, Christoph; Wittes, Janet; Wrolstad, Danielle; de Zeeuw, Dick

    2013-11-01

    Type 2 diabetes mellitus (T2DM) is the most important contributing cause of end-stage renal disease (ESRD) worldwide. Bardoxolone methyl, a nuclear factor-erythroid-2-related factor 2 activator, augments estimated glomerular filtration. The Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial was designed to establish whether bardoxolone methyl slows or prevents progression to ESRD. Herein, we describe baseline characteristics of the BEACON population. BEACON is a randomized double-blind placebo-controlled clinical trial in 2185 patients with T2DM and chronic kidney disease stage 4 (eGFR between 15 and 30 mL/min/1.73 m(2)) designed to test the hypothesis that bardoxolone methyl added to guideline-recommended treatment including inhibitors of the renin-angiotensin-aldosterone system slows or prevents progression to ESRD or cardiovascular death compared with placebo. Baseline characteristics (mean or percentage) of the population include age 68.5 years, female 43%, Caucasian 78%, eGFR 22.5 mL/min/1.73 m(2) and systolic/diastolic blood pressure 140/70 mmHg. The median urinary albumin:creatinine ratio was 320 mg/g and the frequency of micro- and macroalbuminuria was 30 and 51%, respectively. Anemia, abnormalities in markers of bone metabolism and elevations in cardiovascular biomarkers were frequently observed. A history of cardiovascular disease was present in 56%, neuropathy in 47% and retinopathy in 41% of patients. The BEACON trial enrolled a population heretofore unstudied in an international randomized controlled trial. Enrolled patients suffered with numerous co-morbid conditions and exhibited multiple laboratory abnormalities, highlighting the critical need for new therapies to optimize management of these conditions.

  6. Eavesdropping on the "Ping-Pong" Quantum Communication Protocol Freely in a Noise Channel

    OpenAIRE

    Deng, Fu-Guo; Li, Xi-Han; Li, Chun-Yan; Zhou, Ping; Zhou, Hong-Yu

    2005-01-01

    We introduce an attack scheme for eavesdropping the ping-pong quantum communication protocol proposed by Bostr$\\ddot{o}$m and Felbinger [Phys. Rev. Lett. \\textbf{89}, 187902 (2002)] freely in a noise channel. The vicious eavesdropper, Eve, intercepts and measures the travel photon transmitted between the sender and the receiver. Then she replaces the quantum signal with a multi-photon signal in a same state, and measures the photons return with the measuring basis with which Eve prepares the ...

  7. Fault Tolerance in Critical Information Systems

    Science.gov (United States)

    2001-05-01

    that provides an inte- grated editing and analysis environment through the use of the Adobe FrameMaker document processor [1] and the Z/Eves theorem... FrameMaker document processor provid- ing the special character set for Z just as it would any other character set (such as mathe- matical symbols). Zeus...happens to use the LaTeX Z language definition, so Zeus processes the Framemaker spec- ification and outputs the LaTeX translation to Z/Eves for

  8. Security of differential-phase-shift quantum key distribution against individual attacks

    International Nuclear Information System (INIS)

    Waks, Edo; Takesue, Hiroki; Yamamoto, Yoshihisa

    2006-01-01

    We derive a proof of security for the differential-phase-shift quantum key distribution protocol under the assumption that Eve is restricted to individual attacks. The security proof is derived by bounding the average collision probability, which leads directly to a bound on Eve's mutual information on the final key. The security proof applies to realistic sources based on pulsed coherent light. We then compare individual attacks to sequential attacks and show that individual attacks are more powerful

  9. No-signaling quantum key distribution: solution by linear programming

    Science.gov (United States)

    Hwang, Won-Young; Bae, Joonwoo; Killoran, Nathan

    2015-02-01

    We outline a straightforward approach for obtaining a secret key rate using only no-signaling constraints and linear programming. Assuming an individual attack, we consider all possible joint probabilities. Initially, we study only the case where Eve has binary outcomes, and we impose constraints due to the no-signaling principle and given measurement outcomes. Within the remaining space of joint probabilities, by using linear programming, we get bound on the probability of Eve correctly guessing Bob's bit. We then make use of an inequality that relates this guessing probability to the mutual information between Bob and a more general Eve, who is not binary-restricted. Putting our computed bound together with the Csiszár-Körner formula, we obtain a positive key generation rate. The optimal value of this rate agrees with known results, but was calculated in a more straightforward way, offering the potential of generalization to different scenarios.

  10. Foot strike pattern in children during shod-unshod running.

    Science.gov (United States)

    Latorre Román, Pedro Ángel; Balboa, Fernando Redondo; Pinillos, Felipe García

    2017-10-01

    The purpose of this study was to determine the foot strike patterns (FSPs) and neutral support (no INV/EVE and no foot rotation) in children, as well as to determine the influence of shod/unshod conditions and sex. A total of 713 children, aged 6 to 16 years, participated in this study (Age=10.28±2.71years, body mass index [BMI]=19.70±3.91kg/m 2 , 302 girls and 411 boys). A sagittal and frontal-plane video (240Hz) was recorded using a high-speed camcorder, to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/eversion (INV/EVE) and foot rotation on initial contact. RFS prevalence was similar between boys and girls in both shod and unshod conditions. In the unshod condition there was a significant reduction (p<0.001) of RFS prevalence both in boys (shod condition=83.95% vs. 62.65% unshod condition) and in girls (shod condition=87.85% vs. 62.70% unshod condition). No significant differences were found in INV/EVE and foot rotation between sex groups. In the unshod condition there was a significant increase (p<0.001) of neutral support (no INV/EVE) both in boys (shod condition=12.55% vs. 22.22% unshod condition) and in girls (shod condition=17.9% vs. 28.15% unshod condition). In addition, in the unshod condition there is a significant reduction (p<0.001) of neutral support (no foot rotation) both in boys (shod condition=21.55% vs. 11.10% unshod condition) and in girls (shod condition=21.05% vs. 11.95% unshod condition). In children, RFS prevalence is lower than adult's population. Additionally, barefoot running reduced the prevalence of RFS and INV/EVE, however increased foot rotation. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Everolimus plus exemestane versus bevacizumab-based chemotherapy for second-line treatment of hormone receptor-positive metastatic breast cancer in Greece: An economic evaluation study.

    Science.gov (United States)

    Kourlaba, Georgia; Rapti, Vasiliki; Alexopoulos, Athanasios; Relakis, John; Koumakis, Georgios; Chatzikou, Magdalini; Maniadakis, Nikos; Georgoulias, Vassilis

    2015-08-05

    The objective of our study was to conduct a cost-effectiveness (CE) study of combined everolimus (EVE) and exemestane (EXE) versus the common clinical practice in Greece for the treatment of postmenopausal women with HR+/HER2- advanced breast cancer (BC) progressing on nonsteroidal aromatase inhibitors (NSAI). The combinations of bevacizumab (BEV) plus paclitaxel (PACL) and BEV plus capecitabine (CAPE) were selected as comparators. A Markov model, consisting of three health states, was used to describe disease progression and evaluate the CE of the comparators from a third-party payer perspective over a lifetime horizon. Efficacy and safety data as well as utility values considered in the model were extracted from the relevant randomized Phase III clinical trials and other published studies. Direct medical costs referring to the year 2014 were incorporated in the model. A probabilistic sensitivity analysis was conducted to account for uncertainty and variation in the parameters of the model. Primary outcomes were patient survival (life-years), quality-adjusted life years (QALYs), total direct costs and incremental cost-effectiveness ratios (ICER). The discounted quality-adjusted survival of patients treated with EVE plus EXE was greater by 0.035 and 0.004 QALYs, compared to BEV plus PACL and BEV plus CAPE, respectively. EVE plus EXE was the least costly treatment in terms of drug acquisition, administration, and concomitant medications. The total lifetime cost per patient was estimated at €55,022, €67,980, and €62,822 for EVE plus EXE, BEV plus PACL, and BEV plus CAPE, respectively. The probabilistic analysis confirmed the deterministic results. Our results suggest that EVE plus EXE may be a dominant alternative relative to BEV plus PACL and BEV plus CAPE for the treatment of HR+/HER2- advanced BC patients failing initial therapy with NSAIs.

  12. Victims of stalking in India: A study of girl college students in Tirunelveli City

    Directory of Open Access Journals (Sweden)

    Jaishankar Karuppannan

    2007-01-01

    Full Text Available The word 'stalking' was not commonly known in India, until Priyadharshini Mattoo's case (1996 hit the headlines. Eve teasing, a colloquial word for gender harassment is popularly known and Tamil Nadu Prohibition of Eve-Teasing Act, 1998 on that was developed after the brutal killing of a girl named Sarika Shah in Chennai. Though, stalking is there in the past, it was not acknowledged with this terminology and it was always merged with Eve teasing. On the other hand, stalking is much graver than Eve teasing and it is an obsessive behaviour. After the Matoo's case, the Indian Criminal Justice System awoke and the National Commission for Women is ready with a draft Bill (Sexual Assault Prevention Bill to make the Indian Penal Code more effective against the menace of stalkers. Research studies related to stalking in India are sparse and there is a need to study this phenomenon in depth. This paper presents some results from a study of stalking victims among Girl College students at Tirunelveli City, Tamil Nadu, India. In-depth questionnaire data are drawn on to investigate the course and nature of prolonged stalking in 150 self-defined victims. Findings indicate a pattern of repeated intrusions, the stalking harassment methods, lack of reporting behaviour, and effects of stalking on the victims.

  13. Eesti ja Suurbritannia sõlmivad haridusalase koostöölepingu / Olav Kruus

    Index Scriptorium Estoniae

    Kruus, Olav

    2000-01-01

    19. juunil 2000 kirjutasid haridusminister Tõnis Lukas ja Briti haridus- ja tööminister Blackstone alla EV Haridusministeeriumi ja Ühendatud Kuningriigi Haridus- ja Tööministeeriumi ühisavaldusele haridus- ja koolitusalase koostöö kohta

  14. As filhas de Eva: religião e relações de gênero na justiça medieval portuguesa Eve's daughters: religion and gender relations in the portuguese medieval justice

    Directory of Open Access Journals (Sweden)

    Edlene Oliveira Silva

    2011-04-01

    Full Text Available Este artigo analisa as representações de mulheres presentes nas Ordenações Afonsinas, código jurídico português elaborado no século XV que definiu e classificou detalhadamente vários crimes considerados tipicamente femininos e estipulou punições rigorosas. Dentre esses delitos, trataremos de alguns aspectos do adultério, do concubinato e da alcovitagem. Informado pelas representações de gênero, o discurso jurídico do Estado monárquico luso legitimou a perseguição empreendida pela Igreja às mulheres "desviantes". O olhar da justiça era influenciado pelo imaginário religioso cristão e medieval, repleto de ideias patriarcais e misóginas que associavam o feminino ao arquétipo da Eva pecadora, a primeira mulher que se deixou seduzir pelos ardis malignos do demônio.This article analyzes the representations of women in the Ordenações Afonsinas, the Portuguese juridical code elaborated in the 15th century that defined and classified in detail several crimes considered typically feminine, and that stipulated rigorous punishments. Among those crimes, we will discuss some aspects of adultery, concubinage, and panderism. Informed by gender representations, the juridical discourse of the Lusitanian monarchical State legitimated the persecution of "deviating" women undertaken by the Church. The view of justice was influenced by Christian/medieval religious imaginary, full of patriarchal and misogynistic ideas that associated the feminine to Eve's archetype of the sinner, the first woman to be seduced by the Devil's evil artifices.

  15. TALE-mediated modulation of transcriptional enhancers in vivo.

    Science.gov (United States)

    Crocker, Justin; Stern, David L

    2013-08-01

    We tested whether transcription activator-like effectors (TALEs) could mediate repression and activation of endogenous enhancers in the Drosophila genome. TALE repressors (TALERs) targeting each of the five even-skipped (eve) stripe enhancers generated repression specifically of the focal stripes. TALE activators (TALEAs) targeting the eve promoter or enhancers caused increased expression primarily in cells normally activated by the promoter or targeted enhancer, respectively. This effect supports the view that repression acts in a dominant fashion on transcriptional activators and that the activity state of an enhancer influences TALE binding or the ability of the VP16 domain to enhance transcription. In these assays, the Hairy repression domain did not exhibit previously described long-range transcriptional repression activity. The phenotypic effects of TALER and TALEA expression in larvae and adults are consistent with the observed modulations of eve expression. TALEs thus provide a novel tool for detection and functional modulation of transcriptional enhancers in their native genomic context.

  16. La co-educación en el escultismo laico italiano : comunicar valores de igualdad entre las jóvenes y los jóvenes

    OpenAIRE

    Bosna, Valeria Vittoria Aurora

    2014-01-01

    El Escultismo para chicos empezó en Inglaterra en 1907 por Robert Baden Powell y en 1910 antes con Agnes Baden Powell y después con Olave Sant Claire Soames iniciaron el Escultismo femenino y el Guidismo. El Movimiento educativo scout para chicos y chicas es la organización juvenil más difundida al mundo. En Italia el Escultismo masculino y femenino llegó en el 1912 y durante todo el siglo XX trabajó con chicos y chicas de manera separada hasta al 1976. Durante los años cincuenta y sesenta, g...

  17. Magnetic stratigraphy of the Ordovician in the lower reach of the Kotuy River: the age of the Bysy-Yuryakh stratum and the rate of geomagnetic reversals on the eve of the superchron

    Science.gov (United States)

    Pavlov, V. E.; Tolmacheva, T. Yu.; Veselovskiy, R. V.; Latyshev, A. V.; Fetisova, A. M.; Bigun, I. V.

    2017-09-01

    Until recently, the existing data prevented the geophysicists from accurately dating the Bysy-Yuryakh stratum, which outcrops in the middle reach of the Kotuy River, constraining the time of its formation to a wide interval from the end of the Late Cambrian to the beginning of the Silurian. The obtained paleomagnetic data unambiguously correlate the Bysy-Yuryakh stratum to the Nyaian regional stage and constrain its formation, at least a considerable part of it, by the Tremadocian. This result perfectly agrees with the data on the Bysy-Yuryakh conodonts studied in this work and yields a spectacular example of the successful application of paleomagnetic studies in solving important tasks of stratigraphy and, correspondingly, petroleum geology. Within the Bysy-Yuryakh stratum, we revealed a large normal-polarity interval corresponding to the long (>1 Ma) period when the geomagnetic reversals were absent. This result, in combination with the data for the Tremadocian and Middle-Upper Cambrian sequences of the other regions, indicates that (1) the rate of occurrence of the geomagnetic reversals on the eve of the Ordovician Moyero superchron of reversed polarity was at most one reversal per Ma; (2) the superchron does not switch on instantaneously but is preceded by a certain gradual change in the operation conditions of the dynamo mechanism which, inter alia, manifests itself by the reduction of the frequency of geomagnetic reversals with the approach of the superchron. This finding supports the views according to which a process preparing the establishment of the superchrons takes place at the core-mantle boundary.

  18. Disainikaart : Portugal / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2009-01-01

    Portugali arhitektidest, disaineritest, disainifirmadest. Arhitektide Eduardo Souto de Moura (sünd. 1952) ja Alvaro Joaquim de Meio Siza Vieira (sünd. 1933) looming. Firmadest Corque, Mytto, Pedroso & Os-rio, TemaHome, Mood, Munna, Mambo, Delightfulli

  19. Disainikaart : Itaalia / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2009-01-01

    Itaalia disaineritest, disainifirmadest, arhitektidest. Renzo Piano (1937), Aldo Rossi (1931-1997), Alessandro Mendini (1931), Giorgio de Chirico (1888-1978), Federico Fellini (1920-1993), Gaetano Pesce, Ferrari, Alessi, Dolce & Gabbana, Artemide

  20. Disainikaart : Island / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2009-01-01

    Islandi disaineritest, disainifirmadest, arhitektidest. Katrin Olina, Margrét Hardardóttir ja Steve Christer (Studio Granda), Guđjón Samúelsson (1887-1950), Ingibjörg Hanna Bjarnadottir, Hrafnkell Birgisson, Studio Bility jt.

  1. Trepp = Stair / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2006-01-01

    Rakvere Vallimäe trepist. Laste vestlus trepil. Projekt: Kavakava. Autorid: Heidi Urb, Siiri Vallner. Trepi valem: Taavi Vallner. Insener: Marika Stokkeby. Projekt 2004, valmis 2005. Ill.: joonis, 7 värv. fotot

  2. Disainikaart : Hispaania / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2009-01-01

    Hispaania tuntumad arhitektid, disainerid, kunstnikud. Antoni Gaudí (1852-1926), Pablo Picasso (1881-1973), Félix Candela (1910-1997), Marti Guixe, Santiago Calatrava, Herme Ciscar, Monica Garcia, Roger Arquer, Patricia Urquiola, Jaime Hayón

  3. Chicago arhitektuuribiennaal / Eve Komp

    Index Scriptorium Estoniae

    Komp, Eve, 1982-

    2015-01-01

    Chicagos esimest korda korraldatud arhitektuuribiennaali nimi oli "The State of the Art of Architecture", mis toimus 03. oktoober 2015.a. - 03. jaanuar 2016.a. Biennaali eesmärk oli pakkuda rahvusvahelist arhitektuurisündmust kohalikule arhitektuurikogukonnale.

  4. A New Paradigm Hidden in Steganography

    Science.gov (United States)

    2000-01-01

    the n least signi cant bits ( LSB ) of each pixel in the cov- erimage, with the n most signi cant bits (MSB) from the corresponding pixel of the image to...e.g., 2 LSB are (0,0) ) to 3 (e.g., 2 LSB are (1,1) ), it is visually impossible for Eve to detect the steganography . Of course, if Eve has knowl...cryptographic security when the steganography has failed. Simply encrypt the embedded bits so that the 2 LSB in the stegoimage appear as white noise

  5. CPAP Devices for Emergency Prehospital Use: A Bench Study.

    Science.gov (United States)

    Brusasco, Claudia; Corradi, Francesco; De Ferrari, Alessandra; Ball, Lorenzo; Kacmarek, Robert M; Pelosi, Paolo

    2015-12-01

    CPAP is frequently used in prehospital and emergency settings. An air-flow output minimum of 60 L/min and a constant positive pressure are 2 important features for a successful CPAP device. Unlike hospital CPAP devices, which require electricity, CPAP devices for ambulance use need only an oxygen source to function. The aim of the study was to evaluate and compare on a bench model the performance of 3 orofacial mask devices (Ventumask, EasyVent, and Boussignac CPAP system) and 2 helmets (Ventukit and EVE Coulisse) used to apply CPAP in the prehospital setting. A static test evaluated air-flow output, positive pressure applied, and FIO2 delivered by each device. A dynamic test assessed airway pressure stability during simulated ventilation. Efficiency of devices was compared based on oxygen flow needed to generate a minimum air flow of 60 L/min at each CPAP setting. The EasyVent and EVE Coulisse devices delivered significantly higher mean air-flow outputs compared with the Ventumask and Ventukit under all CPAP conditions tested. The Boussignac CPAP system never reached an air-flow output of 60 L/min. The EasyVent had significantly lower pressure excursion than the Ventumask at all CPAP levels, and the EVE Coulisse had lower pressure excursion than the Ventukit at 5, 15, and 20 cm H2O, whereas at 10 cm H2O, no significant difference was observed between the 2 devices. Estimated oxygen consumption was lower for the EasyVent and EVE Coulisse compared with the Ventumask and Ventukit. Air-flow output, pressure applied, FIO2 delivered, device oxygen consumption, and ability to maintain air flow at 60 L/min differed significantly among the CPAP devices tested. Only the EasyVent and EVE Coulisse achieved the required minimum level of air-flow output needed to ensure an effective therapy under all CPAP conditions. Copyright © 2015 by Daedalus Enterprises.

  6. Ethylene evolution and endo-beta-mannanase activity during lettuce seed germination at high temperature Evolução de etileno e atividade da enzima endo-beta-mananase durante a germinação de sementes de alface sob altas temperaturas

    Directory of Open Access Journals (Sweden)

    Warley Marcos Nascimento

    2004-04-01

    Full Text Available High temperatures during lettuce seed imbibition can delay or completely inhibit germination and the endosperm layer appears to restrict the radicle protrusion. The role of endo-beta-mannanase during lettuce seed germination at 35°C and the influence of ethylene in endo-beta-mannanase regulation were investigated. Seeds of 'Dark Green Boston' (DGB and 'Everglades' (EVE were germinated in water, or 10 mmol L-1 of 1-aminocyclopropane-1-carboxylic acid (ACC, or 10 mmol L-1 of aminoethoxyvinylglycine (AVG, or 20 mmol L-1 of silver thiosulphate (STS. Seeds were also primed in polyethylene glycol (PEG, or PEG + ACC, PEG + AVG, or PEG + STS. Untreated seeds germinated 100% at 20°C. At 35°C, EVE seeds germinated 100%, whereas DGB seeds germinated only 33%. Seed priming or adding ACC during incubation increased germination at 35°C. Higher ethylene evolution was detected in EVE than in DGB during germination at 35°C. AVG did not inhibit seed germination of DGB at 35°C, but STS did. Higher endo-beta-mannanase activity was observed in EVE compared with DGB seeds. Providing ACC either during priming or during germination increased endo-beta-mannanase activity, whereas AVG and STS led to decreased or no activity. Ethylene may overcome the inhibitory effect of high temperature in thermosensitive lettuce seeds due to increased endo-beta-mannanase, possibly leading to weakening of the endosperm.Altas temperaturas durante a embebição das sementes de alface podem atrasar ou inibir a germinação e o endosperma parece ser o responsável na restrição da protrusão da radícula. O envolvimento da enzima endo-beta-mananase durante a germinação de sementes de alface a 35°C e a influência do etileno na regulagem desta enzima foram estudados. Sementes das cultivares Dark Green Boston (DGB e Everglades (EVE foram germinadas em água ou em soluções de 10 mmol L-1 de 1-aminociclopropano-1-ácido carboxilico (ACC, 10 mmol L-1 de amino-etoxi-vinil-glicina (AVG

  7. Circulating tumor cells in melanoma patients.

    Directory of Open Access Journals (Sweden)

    Gary A Clawson

    Full Text Available Circulating tumor cells (CTCs are of recognized importance for diagnosis and prognosis of cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels and stage of disease. Here, CTCs were enriched (∼400X from blood of melanoma patients using a simple centrifugation device (OncoQuick, and 4 melanocyte target RNAs (TYR, MLANA, MITF, and MIF were quantified using QPCR. Approximately one-third of melanoma patients had elevated MIF and MLANA transcripts (p<0.0001 and p<0.001, respectively compared with healthy controls. In contrast, healthy controls had uniformly higher levels of TYR and MITF than melanoma patients (p<0.0001. There was a marked shift of leukocytes into the CTC-enriched fractions (a 430% increase in RNA recovery, p<0.001, and no relationship between CTC levels and stage of disease was found. CTCs were captured on microfabricated filters and cultured. Captured melanoma CTCs were large cells, and consisted of 2 subpopulations, based on immunoreactivity. One subpopulation (∼50% stained for both pan-cytokeratin (KRT markers and the common leukocyte marker CD-45, whereas the second subpopulation stained for only KRT. Since similar cells are described in many cancers, we also examined blood from colorectal and pancreatic cancer patients. We observed analogous results, with most captured CTCs staining for both CD-45/KRT markers (and for the monocyte differentiation marker CD-14. Our results suggest that immature melanocyte-related cells (expressing TYR and MITF RNA may circulate in healthy controls, although they are not readily detectable without considerable enrichment. Further, as early-stage melanomas develop, immature melanocyte migration into the blood is somehow curtailed, whereas a significant proportion of patients develop elevated CTC levels (based on MIF and MLANA RNAs. The nature of the captured CTCs is consistent with literature describing leukocyte/macrophage-tumor cell fusion hybrids

  8. Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study.

    Science.gov (United States)

    Krueger, James; Clark, James D; Suárez-Fariñas, Mayte; Fuentes-Duculan, Judilyn; Cueto, Inna; Wang, Claire Q; Tan, Huaming; Wolk, Robert; Rottinghaus, Scott T; Whitley, Maryann Z; Valdez, Hernan; von Schack, David; O'Neil, Shawn P; Reddy, Padmalatha S; Tatulych, Svitlana

    2016-04-01

    Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. We sought to elucidate the molecular mechanisms underlying the clinical efficacy of tofacitinib in patients with psoriasis. Twelve patients with plaque psoriasis were randomized (3:1) to receive 10 mg of tofacitinib or placebo twice daily for 12 weeks. Biopsy specimens were taken from nonlesional (baseline) and lesional (baseline, days 1 and 3, and weeks 1, 2, 4, and 12) skin. Biopsy specimens were examined for psoriatic epidermal features (thickness, Ki67(+) keratinocytes and keratin 16 [KRT16] mRNA expression, and phosphorylated signal transducer and activator of transcription [pSTAT](+) nuclei) and T-cell and dendritic cell (DC) subsets by using immunohistochemistry, and mRNA transcripts were quantified by using a microarray. In lesional skin keratinocyte pSTAT1 and pSTAT3 staining was increased at baseline but reduced after 1 day of tofacitinib (baseline, median of 1290 pSTAT1(+) cells/μm(2); day 1, median of 332 pSTAT1(+) cells/μm(2); and nonlesional, median of 155 pSTAT1(+) cells/μm(2)). Epidermal thickness and KRT16 mRNA expression were significantly and progressively reduced after days 1 and 3 of tofacitinib administration, respectively (eg, KRT16 decreased 2.74-fold, day 3 vs baseline, P = .016). Decreases in DC and T-cell numbers were observed after weeks 1 and 2, respectively. At week 4, significant decreases in IL-23/TH17 pathways were observed that persisted through week 12. Improvements in clinical and histologic features were strongly associated with changes in expression of psoriasis-related genes and reduction in IL-17 gene expression. Tofacitinib has a multitiered response in patients with psoriasis: (1) rapid attenuation of keratinocyte Janus kinase/STAT signaling; (2) removal of keratinocyte-induced cytokine signaling, leading to reductions in pathologic DC and T-cell numbers to nonlesional levels; and (3) inhibition of the IL-23/TH17 pathway. Copyright © 2016

  9. Zippo Marx

    Directory of Open Access Journals (Sweden)

    Robin Aaron Bright

    2017-09-01

    Full Text Available Goddesses, like Norse Hel, signify love for women, and between women, because `woman`s seed` is the `seed` of Eve represented by Jesus, who was tortured to death by the Romans as a `dissident` Jewish rabbi nailed to a cross of wood on the hill of Calvary outside the city of Jerusalem in occupied Palestine and left there until he died. Jesus` Resurrection and Ascension to heaven thereafter prefigured that of `woman`s seed`, which is why his mother, the Virgin Mary, approaches to the role of goddess in Christianity, because women who`re loved appear to be worshipped as goddesses by those who don`t love women. So God specifically punishes Eve and Adam for accepting that they`ll be `as gods`, because Eve is Adam`s `goddess`, who he`s to love in order to be redeemed through `woman`s seed`, and the birth of human brainpower to liberate the species from host womb slavery in parasitism, which wants ephemerality for humans in order to keep them as slaves without labor saving technologies conferring freedom.

  10. Tänavune Jõulujazz tuleb Olav Ehala ja Courtney Pine'iga / Madli-Liis Parts

    Index Scriptorium Estoniae

    Parts, Madli-Liis, 1969-

    2005-01-01

    Jazzüritustest: rootsi jazzlauljatari Rigmor Gustafssoni kontserdist 8. dets. Estonia kontserdisaalis, inglise saksofonisti Courtney Pine heliplaadi "Resistance" esitluskontserdist 15. dets. Rock Café's, Eesti Raadio ja Jazzkaare heategevuskontserdist "Aita alustada elu" O. Ehala muusikaga, Moskva vokaalkvarteti Cool & Jazzy kontserdist, Hedvig Hansoni kontserdist "Vaikuse kaja" 1. dets. Nigulistes

  11. A New Quantum Secure Direct Communication Scheme with Authentication

    International Nuclear Information System (INIS)

    Dan, Liu; Chang-Xing, Pei; Dong-Xiao, Quan; Nan, Zhao

    2010-01-01

    A new quantum secure direct communication (QSDC) scheme with authentication is proposed based on polarized photons and EPR pairs. EPR pairs are used to transmit information, while polarized photons are used to detect Eve and their encoding bases are used to transmit authentication information. Alice and Bob have their own identity number which is shared by legal users only. The identity number is encoded on the bases of polarized photons and distilled if there is no Eve. Compared with other QSDC schemes with authentication, this new scheme is considerably easier and less expensive to implement in a practical setting

  12. Upconversion-based receivers for quantum hacking-resistant quantum key distribution

    Science.gov (United States)

    Jain, Nitin; Kanter, Gregory S.

    2016-07-01

    We propose a novel upconversion (sum frequency generation)-based quantum-optical system design that can be employed as a receiver (Bob) in practical quantum key distribution systems. The pump governing the upconversion process is produced and utilized inside the physical receiver, making its access or control unrealistic for an external adversary (Eve). This pump facilitates several properties which permit Bob to define and control the modes that can participate in the quantum measurement. Furthermore, by manipulating and monitoring the characteristics of the pump pulses, Bob can detect a wide range of quantum hacking attacks launched by Eve.

  13. Systematic kidney disease management in a population with diabetes mellitus: turning the tide of kidney failure.

    Science.gov (United States)

    Rayner, Hugh C; Hollingworth, Lee; Higgins, Robert; Dodds, Simon

    2011-10-01

    A significant proportion of patients with diabetes mellitus do not get the benefit of treatment that would reduce their risk of progressive kidney disease and reach a nephrologist once significant loss of kidney function has already occurred. Systematic disease management of patients with diabetes and kidney disease. Diverse population (approximately 800,000) in and around Birmingham, West Midlands, UK. Number of outpatient appointments, estimated glomerular filtration rate (eGFR) at first contact with nephrologist, number of patients starting kidney replacement therapy (KRT) and mode of KRT at start. Identification of patients with low or deteriorating trend in eGFR from weekly database review, specialist diabetes-kidney clinic, self-management of blood pressure and transfer to multidisciplinary clinic >12 months before end-stage kidney disease. New patients increased from 62 in 2003 to 132 in 2010; follow-ups fell from 251 to 174. Median eGFR at first clinic visit increased from 28.8 ml/min/1.73 m(2) (range 6.1-67.0) in 2000/2001 to 35.0 (11.1-147.5) in 2010 (pmanagement across a large population significantly improves patient outcomes, increases the productivity of a specialist service and could reduce healthcare costs compared with the current model of care.

  14. The effect of screening doors and windows on indoor density of Anopheles arabiensis in south-west Ethiopia: a randomized trial.

    Science.gov (United States)

    Massebo, Fekadu; Lindtjørn, Bernt

    2013-09-12

    Screening of houses might have impact on density of indoor host-seeking Anopheles mosquitoes. A randomized trial of screening windows and doors with metal mesh, and closing openings on eves and walls by mud was conducted to assess if reduce indoor densities of biting mosquitoes. Mosquitoes were collected in forty houses using Centers for Diseases Control and Prevention (CDC) light traps biweekly in March and April 2011. A randomization of houses into control and intervention groups was done based on the baseline data. Windows and doors of 20 houses were screened by metal mesh, and openings on the walls and eves closed by mud and the rest 20 houses were used as control group. Mosquitoes were collected biweekly in October and November 2011 from both control and intervention houses. A Generalized Estimating Equations (GEE) with a negative binomial error distribution was used to account for over dispersion of Anopheles arabiensis and culicine counts and repeated catches made in the same house. Screening doors and windows, and closing openings on eves and wall by mud reduced the overall indoor densities of An. arabiensis by 40%. The effect of screenings pronounced on unfed An. arabiensis by resulting 42% reduction in houses with interventions. The total costs for screening windows and doors, and to close openings on the eves and walls by mud was 7.34 USD per house. Screening houses reduced indoor density of An. arabiensis, and it was cheap and can easily incorporated into malaria vector strategies by local communities, but improving doors and windows fitness for screening should be considered during house construction to increase the efficacy of screenings.

  15. Sotsiaalkapitali roll majandusarengus / Eve Parts

    Index Scriptorium Estoniae

    Parts, Eve, 1970-

    2006-01-01

    Sotsiaalkapitali lülitamise võimalustest iseseisva lisamuutujana traditsioonilistesse kasvumudelitesse, võimalikest sisulistest mõjumehhanismidest, mõjust inimkapitalile ning institutsionaalse efektiivsuse ja sotsiaalse heaoluga seotud arengueesmärkide saavutamisele. Skeemid. Tabelid

  16. Onu Bella kollektsiooniaed / Eve Veigel

    Index Scriptorium Estoniae

    Veigel, Eve, 1961-

    2005-01-01

    Laulja, Põlva raadiojaama Marta FM pühapäevaprogrammi "Vox Humana" juhi Onu Bella (Igor Maasik) koduaiast Tartus. Onu Bella on kasvatanud roose, okaspuuvorme, praegu tegeleb mini-dendropargi rajamisega. 12 ill

  17. Pedagoogiline praktika õpetajakoolituses / Eve Eisenschmidt

    Index Scriptorium Estoniae

    Eisenschmidt, Eve, 1963-

    2003-01-01

    Lahendused pedagoogilise praktika tõhustamiseks. Pedagoogilise praktika osatähtsuse hindamiseks üliõpilaste professionaalse enesekontseptsiooni kujunemisel ja juhendaja rolli väljaselgitamisel küsitleti Haapsalu Kolledži III kursuse klassiõpetaja eriala üliõpilasi, kes viibisid I kooliastme viienädalasel praktikal 2002.a. veebruaris-märtsis

  18. Põrand kannab sisustust / Eve Variksoo

    Index Scriptorium Estoniae

    Variksoo, Eve

    1998-01-01

    Vanadest ja uutest põrandakatetest, nagu laudpõrand, laudparkett, liistparkett, laminaatpõrand, linoleum, PVC põrandakatted, kivipõrand, korkkatted, vaipkatted, sisal, kookos, keraamilised plaadid. Põrandaküttega sobivatest ja sobimatutest materjalidest. Armsast puupõrandast.

  19. Lõhe Res Publicas / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2005-01-01

    Tallinna linnapea Tõnis Palts on vastu Tallinna volikogu Res Publica fraktsiooni esimehe Toomas Tautsi abikaasa Kristina Tautsi tööleasumisele Lääne-Tallinna keskhaigla haldusjuhina. T. Paltsi kirjast Res Publica Tallinna piirkonna juhatusele. Lisa: Kuidas lahvatas pealinna võimutüli. Kommenteerivad: Maret Maripuu, Tõnis Palts, Vladimir Maslov

  20. Kas saatejuht vastutab? / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2004-01-01

    Vt. ka Vesti Dnja 22. sept., lk. 6. Urmas Oti intervjuust 15. aastase koolipoisiga Tšetšeenia teemal telesaates "Happy Hour". Lastekaitse Liidu hinnangul ei lähtunud saatejuht lapse huvidest. Lisaks: Urmas Oti küsimused tšetšeeni poisile

  1. At the Eve of Convergence?

    DEFF Research Database (Denmark)

    Henriksen, Lars Skov; Zimmer, Annette; Smith, Steven Rathgeb

    . Specifically, we will investigate whether and to what extent social services and health care in these three countries are affected by current changes. With a special focus on nonprofit organizations, we will particularly address the question whether a trend towards convergence of the very different welfare......Due to severe societal, economic and political changes, of which the financial crisis counts prominently, welfare states all over the world are under stress. In our comparative analysis, we will concentrate on specific segments of welfare state activity in Denmark, Germany, and the United States...

  2. Trace element analysis of blackish staining on the crowns of human archaeological teeth

    International Nuclear Information System (INIS)

    Stermer, E.M.; Risnes, S.; Fischer, P.M.

    1996-01-01

    A blackish staining found on the crowns of teeth of 51 skulls from the excavation of the medieval St. Olav's church in Trondheim was analyzed using secondary ion mass spectrometry (SIMS) and atomic absorption spectrometry (AAS). In four teeth, mass spectra and step scan concentration profiles of SIMS were performed and compared with the grey scale pattern in photographs of the analyzed paths. The manganese curve showed the highest degree of conformity with the grey scale pattern. The AAS analysis confirmed the increased content of manganese in blackish stained enamel. It was concluded that manganese, probably in the form of an oxide deposited from the soil, was the cause of the blackish staining. (au)

  3. Genética Molecular das Epidermólises Bolhosas Molecular Genetics of Epidermolysis Bullosa

    Directory of Open Access Journals (Sweden)

    Hiram Larangeira de Almeida Jr

    2002-10-01

    Full Text Available O estudo das alterações moleculares das epidermólises bolhosas tem contribuído para que se compreenda melhor essas enfermidades. Na epidermólise bolhosa simples a maioria dos casos está associada com alteração nas citoqueratinas basais 5 (gen KRT5 e 14 (gen KRT14, o que modifica o citoesqueleto na camada basal da epiderme, levando à degeneração dessa camada, formando bolha intra-epidérmica. Mutações na plectina (gen PLEC1, componente da placa interna do hemidesmossoma, levam também à clivagem intra-epidérmica. Na epidermólise bolhosa juncional vários gens estão envolvidos, em decorrência da complexidade da zona da membrana basal, todos levando ao descolamento dos queratinócitos basais na lâmina lúcida, pela disfunção da aderência entre esses e a lâmina densa. Alterações na laminina 5 (gens LAMA3, LAMB3 e LAMC2, integrina alfa6beta4 (gens ITGA6 e ITGB4 e colágeno XVII (gen COL17A1 foram descritas. Por fim, na epidermólise bolhosa distrófica apenas um gen está mutado, alterando o colágeno VII (gen COL7A1, principal componente das fibrilas ancorantes, produzindo clivagem abaixo da lâmina densa, variando fenotipicamente de acordo com a conseqüência da mutação. Outra aplicação importante dessas informações refere-se ao diagnóstico pré-natal, com a perspectiva no futuro da terapia gênica.New data regarding the molecular aspects of the heterogeneous group of epidermolysis bullosa has brought some important information about its pathogenesis. In epidermolysis bullosa simplex the majority of mutations are localized in the genes of the basal cytokeratin 5 (gene KRT5 and 14 (gene KRT14, cytolysis at this layer with intraepidermal blister is seen under light microscopy. Mutations of plectin (gene PLEC1, a protein found in the inner hemidesmosomal plaque, leads also to intraepidermal blisters. In junctional epidermolysis bullosa many proteins from the basal membrane zone are involved, such as laminin 5 (genes

  4. Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

    International Nuclear Information System (INIS)

    Turashvili, Gulisa; Srovnal, Josef; Hajduch, Marian; Murray, Paul; Kolar, Zdenek; Bouchal, Jan; Baumforth, Karl; Wei, Wenbin; Dziechciarkova, Marta; Ehrmann, Jiri; Klein, Jiri; Fridman, Eduard; Skarda, Jozef

    2007-01-01

    Invasive ductal and lobular carcinomas (IDC and ILC) are the most common histological types of breast cancer. Clinical follow-up data and metastatic patterns suggest that the development and progression of these tumors are different. The aim of our study was to identify gene expression profiles of IDC and ILC in relation to normal breast epithelial cells. We examined 30 samples (normal ductal and lobular cells from 10 patients, IDC cells from 5 patients, ILC cells from 5 patients) microdissected from cryosections of ten mastectomy specimens from postmenopausal patients. Fifty nanograms of total RNA were amplified and labeled by PCR and in vitro transcription. Samples were analysed upon Affymetrix U133 Plus 2.0 Arrays. The expression of seven differentially expressed genes (CDH1, EMP1, DDR1, DVL1, KRT5, KRT6, KRT17) was verified by immunohistochemistry on tissue microarrays. Expression of ASPN mRNA was validated by in situ hybridization on frozen sections, and CTHRC1, ASPN and COL3A1 were tested by PCR. Using GCOS pairwise comparison algorithm and rank products we have identified 84 named genes common to ILC versus normal cell types, 74 named genes common to IDC versus normal cell types, 78 named genes differentially expressed between normal ductal and lobular cells, and 28 named genes between IDC and ILC. Genes distinguishing between IDC and ILC are involved in epithelial-mesenchymal transition, TGF-beta and Wnt signaling. These changes were present in both tumor types but appeared to be more prominent in ILC. Immunohistochemistry for several novel markers (EMP1, DVL1, DDR1) distinguished large sets of IDC from ILC. IDC and ILC can be differentiated both at the gene and protein levels. In this study we report two candidate genes, asporin (ASPN) and collagen triple helix repeat containing 1 (CTHRC1) which might be significant in breast carcinogenesis. Besides E-cadherin, the proteins validated on tissue microarrays (EMP1, DVL1, DDR1) may represent novel

  5. Identification and expression analysis of genes associated with bovine blastocyst formation

    Directory of Open Access Journals (Sweden)

    Van Zeveren Alex

    2007-06-01

    Full Text Available Abstract Background Normal preimplantation embryo development encompasses a series of events including first cleavage division, activation of the embryonic genome, compaction and blastocyst formation. First lineage differentiation starts at the blastocyst stage with the formation of the trophectoderm and the inner cell mass. The main objective of this study was the detection, identification and expression analysis of genes associated with blastocyst formation in order to help us better understand this process. This information could lead to improvements of in vitro embryo production procedures. Results A subtractive cDNA library was constructed enriched for transcripts preferentially expressed at the blastocyst stage compared to the 2-cell and 8-cell stage. Sequence information was obtained for 65 randomly selected clones. The RNA expression levels of 12 candidate genes were determined throughout 3 stages of preimplantation embryo development (2-cell, 8-cell and blastocyst and compared with the RNA expression levels of in vivo "golden standard" embryos using real-time PCR. The RNA expression profiles of 9 (75% transcripts (KRT18, FN1, MYL6, ATP1B3, FTH1, HINT1, SLC25A5, ATP6V0B, RPL10 were in agreement with the subtractive cDNA cloning approach, whereas for the remaining 3 (25% (ACTN1, COPE, EEF1A1 the RNA expression level was equal or even higher at the earlier developmental stages compared to the blastocyst stage. Moreover, significant differences in RNA expression levels were observed between in vitro and in vivo produced embryos. By immunofluorescent labelling, the protein expression of KRT18, FN1 and MYL6 was determined throughout bovine preimplantation embryo development and showed the same pattern as the RNA expression analyses. Conclusion By subtractive cDNA cloning, candidate genes involved in blastocyst formation were identified. For several candidate genes, important differences in gene expression were observed between in vivo and in

  6. Exploring if day and time of admission is associated with average length of stay among inpatients from a tertiary hospital in Singapore: an analytic study based on routine admission data.

    Science.gov (United States)

    Earnest, Arul; Chen, Mark I C; Seow, Eillyne

    2006-01-22

    It has been postulated that patients admitted on weekends or after office hours may experience delays in clinical management and consequently have longer length of stay (LOS). We investigated if day and time of admission is associated with LOS in Tan Tock Seng Hospital (TTSH), a 1,400 bed acute care tertiary hospital serving the central and northern regions of Singapore. This was a historical cohort study based on all admissions from TTSH from 1st September 2003 to 31st August 2004. Data was extracted from routinely available computerized hospital information systems for analysis by episode of care. LOS for each episode of care was log-transformed before analysis, and a multivariate linear regression model was used to study if sex, age group, type of admission, admission source, day of week admitted, admission on a public holiday or eve of public holiday, admission on a weekend and admission time were associated with an increased LOS. In the multivariate analysis, sex, age group, type of admission, source of admission, admission on the eve of public holiday and weekends and time of day admitted were independently and significantly associated with LOS. Patients admitted on Friday, Saturday or Sunday stayed on average 0.3 days longer than those admitted on weekdays, after adjusting for potential confounders; those admitted on the eve of public holidays, and those admitted in the afternoons and after office hours also had a longer LOS (differences of 0.71, 1.14 and 0.65 days respectively). Cases admitted over a weekend, eve of holiday, in the afternoons, and after office hours, do have an increased LOS. Further research is needed to identify processes contributing to the above phenomenon.

  7. Exploring if day and time of admission is associated with average length of stay among inpatients from a tertiary hospital in Singapore: an analytic study based on routine admission data

    Directory of Open Access Journals (Sweden)

    Chen Mark IC

    2006-01-01

    Full Text Available Abstract Background It has been postulated that patients admitted on weekends or after office hours may experience delays in clinical management and consequently have longer length of stay (LOS. We investigated if day and time of admission is associated with LOS in Tan Tock Seng Hospital (TTSH, a 1,400 bed acute care tertiary hospital serving the central and northern regions of Singapore. Methods This was a historical cohort study based on all admissions from TTSH from 1st September 2003 to 31st August 2004. Data was extracted from routinely available computerized hospital information systems for analysis by episode of care. LOS for each episode of care was log-transformed before analysis, and a multivariate linear regression model was used to study if sex, age group, type of admission, admission source, day of week admitted, admission on a public holiday or eve of public holiday, admission on a weekend and admission time were associated with an increased LOS. Results In the multivariate analysis, sex, age group, type of admission, source of admission, admission on the eve of public holiday and weekends and time of day admitted were independently and significantly associated with LOS. Patients admitted on Friday, Saturday or Sunday stayed on average 0.3 days longer than those admitted on weekdays, after adjusting for potential confounders; those admitted on the eve of public holidays, and those admitted in the afternoons and after office hours also had a longer LOS (differences of 0.71, 1.14 and 0.65 days respectively. Conclusion Cases admitted over a weekend, eve of holiday, in the afternoons, and after office hours, do have an increased LOS. Further research is needed to identify processes contributing to the above phenomenon.

  8. Security proof of counterfactual quantum cryptography against general intercept-resend attacks and its vulnerability

    International Nuclear Information System (INIS)

    Zhang Sheng; Wang Jian; Tang Chao-Jing

    2012-01-01

    Counterfactual quantum cryptography, recently proposed by Noh, is featured with no transmission of signal particles. This exhibits evident security advantages, such as its immunity to the well-known photon-number-splitting attack. In this paper, the theoretical security of counterfactual quantum cryptography protocol against the general intercept-resend attacks is proved by bounding the information of an eavesdropper Eve more tightly than in Yin's proposal [Phys. Rev. A 82 042335 (2010)]. It is also shown that practical counterfactual quantum cryptography implementations may be vulnerable when equipped with imperfect apparatuses, by proving that a negative key rate can be achieved when Eve launches a time-shift attack based on imperfect detector efficiency. (general)

  9. Foot strike pattern in preschool children during running: sex and shod-unshod differences.

    Science.gov (United States)

    Latorre-Román, Pedro Á; Párraga-Montilla, Juan A; Guardia-Monteagudo, Ignacio; García-Pinillos, Felipe

    2018-04-01

    This study aims to determine the foot strike patterns (FSPs) and neutral support (no inversion [INV]/eversion [EVE] and no foot rotation) in preschool children, as well as to determine the influence of shod/unshod conditions and sex. A total of 1356 children aged 3-6 years (673 boys and 683 girls) participated in this study. A sagittal and frontal-plane video (240 Hz) was recorded using a high-speed camcorder to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/ eversion (INV/EVE) and foot rotation on initial contact. There were no between-sex significant differences in both shod and unshod conditions in RFS. In the unshod condition, there was a significant reduction (p < 0.001) of RFS prevalence in both boys (shod condition = 44.2% vs. 34.7% unshod condition) and girls (shod condition = 48.5% vs. 36.1% unshod condition). As for neutral support, there were no between-sex differences in both shod and unshod conditions or in the shod-unshod comparison. In preschool children, no between-sex differences were found in relation to prevalence of RFS and neutral support (no INV/EVE). Shod running alters FSP of running barefoot, producing a significant increase of RFS prevalence.

  10. Stochastic model for gene transcription on Drosophila melanogaster embryos

    Science.gov (United States)

    Prata, Guilherme N.; Hornos, José Eduardo M.; Ramos, Alexandre F.

    2016-02-01

    We examine immunostaining experimental data for the formation of stripe 2 of even-skipped (eve) transcripts on D. melanogaster embryos. An estimate of the factor converting immunofluorescence intensity units into molecular numbers is given. The analysis of the eve dynamics at the region of stripe 2 suggests that the promoter site of the gene has two distinct regimes: an earlier phase when it is predominantly activated until a critical time when it becomes mainly repressed. That suggests proposing a stochastic binary model for gene transcription on D. melanogaster embryos. Our model has two random variables: the transcripts number and the state of the source of mRNAs given as active or repressed. We are able to reproduce available experimental data for the average number of transcripts. An analysis of the random fluctuations on the number of eves and their consequences on the spatial precision of stripe 2 is presented. We show that the position of the anterior or posterior borders fluctuate around their average position by ˜1 % of the embryo length, which is similar to what is found experimentally. The fitting of data by such a simple model suggests that it can be useful to understand the functions of randomness during developmental processes.

  11. A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.

    Science.gov (United States)

    Khan, Anwar Kamal; Muhammad, Noor; Aziz, Abdul; Khan, Sher Alam; Shah, Khadim; Nasir, Abdul; Khan, Muzammil Ahmad; Khan, Saadullah

    2017-04-12

    Pure hair and nail ectodermal dysplasia (PHNED) is a congenital disorder of hair abnormalities and nail dysplasia. Both autosomal recessive and dominant inheritance fashion of PHNED occurs. In literature, to date, five different forms of PHNED have been reported at molecular level, having three genes known and two loci with no gene yet. In this study, a four generations consanguineous family of Pakistani origin with autosomal recessive PHNED was investigated. Affected members exhibited PHNED phenotypes with involvement of complete hair loss and nail dysplasia. To screen for mutation in the genes (HOXC13, KRT74, KRT85), its coding exons and exons-intron boundaries were sequenced. The 3D models of normal and mutated HOXC13 were predicted by using homology modeling. Through investigating the family to known loci, the family was mapped to ectodermal dysplasia 9 (ECTD9) loci with genetic address of 12q13.13. Mutation screening revealed a novel missense mutation (c.929A > C; p.Asn310Thr) in homeobox DNA binding domain of HOXC13 gene in affected members of the family. Due to mutation, loss of hydrogen bonding and difference in potential energy occurs, which may resulting in alteration of protein function. This is the first mutation reported in homeodomain, while 5 th mutation reported in HOXC13 gene causing PHNED.

  12. Genome-Wide DNA Methylation Indicates Silencing of Tumor Suppressor Genes in Uterine Leiomyoma

    Science.gov (United States)

    Navarro, Antonia; Yin, Ping; Monsivais, Diana; Lin, Simon M.; Du, Pan; Wei, Jian-Jun; Bulun, Serdar E.

    2012-01-01

    Background Uterine leiomyomas, or fibroids, represent the most common benign tumor of the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to 70% of African American women of reproductive age. Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities remains unknown. Principal Findings We characterized and compared genome-wide DNA methylation and mRNA expression profiles in uterine leiomyoma and matched adjacent normal myometrial tissues from 18 African American women. We found 55 genes with differential promoter methylation and concominant differences in mRNA expression in uterine leiomyoma versus normal myometrium. Eighty percent of the identified genes showed an inverse relationship between DNA methylation status and mRNA expression in uterine leiomyoma tissues, and the majority of genes (62%) displayed hypermethylation associated with gene silencing. We selected three genes, the known tumor suppressors KLF11, DLEC1, and KRT19 and verified promoter hypermethylation, mRNA repression and protein expression using bisulfite sequencing, real-time PCR and western blot. Incubation of primary leiomyoma smooth muscle cells with a DNA methyltransferase inhibitor restored KLF11, DLEC1 and KRT19 mRNA levels. Conclusions These results suggest a possible functional role of promoter DNA methylation-mediated gene silencing in the pathogenesis of uterine leiomyoma in African American women. PMID:22428009

  13. Advanced glycosylation end product promotes forkhead box O1 and inhibits Wnt pathway to suppress capacities of epidermal stem cells.

    Science.gov (United States)

    Zhu, Jie; Wang, Peng; Yu, Zhimin; Lai, Wei; Cao, Yi; Huang, Pinbo; Xu, Qiaodong; Yu, Menglei; Xu, Junyao; Huang, Zitong; Zeng, Bing

    2016-01-01

    Diabetes mellitus is frequently accompanied by chronic complications like delayed wound healing, which is consider to be attributed to the accumulation of advanced glycosylation end product (AGE). However, the impacts of AGE on epidermal stem cells (ESCs) are largely unknown. This study aims to address the influence and mechanism of AGE on ESCs. ESCs isolated from rats were cultured in AGE-modified bovine serum albumin and transfected with small interfering RNA to knock down AGE-specific receptor (AGER). Expression of stem cell markers integrin β1 (ITGB1) and keratin 19 (KRT19), cell viability, apoptosis and reactive oxygen species (ROS) were examined. Wnt pathway-related factors Wnt family member 1 (WNT1), WNT3A, β-catenin, v-myc avian myelocytomatosis viral oncogene homolog (MYC), cyclin D1 (CCND1) and matrix metallopeptidase 7 (MMP7) were quantified. The interaction between forkhead box O1 (FOXO1) and β-catenin was assessed by co-immunoprecipitation. Results indicated that AGE down-regulated ITGB1 and KRT19 expression, suppressed ESC viability and promoted apoptosis, and ROS level ( P factor 1 to interact with β-catenin, which might help to elucidate the mechanism of AGE repressing ESCs. This study helps to understand the mechanism of accumulated AGE in affecting ESC capacities, and provides potential therapeutic targets to meliorate diabetic wound healing.

  14. Hula Black - Eesti haute couture / Maria Ulfsak

    Index Scriptorium Estoniae

    Ulfsak, Maria, 1981-

    2003-01-01

    Esitleti uut Hula noortekomplekti Black, mille autorid on Anu Lensmant, Marit Ahven, Reet Ulfsak, Eve Hanson, Ruta Tepp, Ketlin Bachmann ja ehtekunstnikud Andrus Rumm, Julia-Maria Pihlak, Tanel Veenre

  15. Selgusi selle aasta parimad sportlased / Ketlin Bejaev

    Index Scriptorium Estoniae

    Bejaev, Ketlin

    2006-01-01

    Tartu tänavune parim meessportlane on karate maailmameister Marko Luhamaa, tema treener Jüri Post pälvis aasta treeneri tiitli. Parimaks naissportlaseks tunnistati laskeorienteerumise maailmameister Eveli Saue

  16. Tallinnas võistlevad üheminutifilmid

    Index Scriptorium Estoniae

    2001-01-01

    Tallinnas toimuvad täna UNICA 63. ülemaailmse amatöörfilmide festivali raames üheminutiliste filmide maailmameistrivõistlused. Eestit esindab Tõnu Aru ja Eve Esteri film "Friendly" ("Sõbralikult")

  17. Moskovskije oligarhi predpotshitajut / Tatjana Tridvornova ; interv. Marina Poltavtseva

    Index Scriptorium Estoniae

    Tridvornova, Tatjana

    2005-01-01

    Lilleballi ja Lillekleidi konkursi autori Tatjana Tridvornovaga tema tööst Moskvas. Avas Moskvas kunstistuudio Flowers Vasari. Tema abilisteks on eesti lilleseadjad Heiti Põder, Ahti Lyra ja Eve Aben

  18. Summer Camp July 2017 - Registration

    CERN Multimedia

    EVE et École

    2017-01-01

    The CERN Staff Association’s Summer Camp will be open for children from 4 to 6 years old during four weeks, from 3 to 28 July. Registration is offered on a weekly basis for 450 CHF, lunch included. This year, the various activities will revolve around the theme of the Four Elements. Registration opened on 20 March 2017 for children currently attending the EVE and School of the Association. It will be open from 3 April for children of CERN Members of Personnel, and starting from 24 April for all other children. The general conditions are available on the website of the EVE and School of CERN Staff Association: http://nurseryschool.web.cern.ch. For further questions, please contact us by email at Summer.Camp@cern.ch.

  19. Eesti graafikud Krakówi triennaalil

    Index Scriptorium Estoniae

    2009-01-01

    16. septembril Poolas avatud Krakówi rahvusvahelise graafikatriennaali peanäitusel ja satelliitnäitustel esindavad Eestit Eve Kask, Ülle Marks, Benjamin Vasserman, Tiiu Prisko, Mati Veermets, Evi Tihemets

  20. Oliivipuude triloogia - mõnus suvine võrkkiige-lugemine / Mari Klein

    Index Scriptorium Estoniae

    Klein, Mari

    2007-01-01

    Tutvustus: Drinkwater, Carol. Oliiviistandus / tlk. Laine Hone. Tallinn : Varrak, 2004 ; Drinkwater, Carol. Oliivisaak / tlk. Eve-Reet Tammet. Tallinn : Varrak, 2997 ; Drinkwater, Carol. Oliivihooaeg / tlk. Lane Hone ja Karin Rita. Tallinn : Varrak, 2006

  1. Contextualising sexual harassment of adolescent girls in Bangladesh.

    Science.gov (United States)

    Nahar, Papreen; van Reeuwijk, Miranda; Reis, Ria

    2013-05-01

    Violence against women is a social mechanism confirming women's subordination in many societies. Sexual violence and harassment have various negative psychological impacts on girls, including a persistent feeling of insecurity and loss of self-esteem. This article aims to contextualize a particular form of sexual harassment, namely "eve teasing", experienced by Bangladeshi adolescent girls (12-18 years) which emerged from a study of adolescent sexual behaviour carried out by young people. The study used qualitative methods and a participatory approach, including focus group discussions, key informant interviews and observation. Despite taboos, unmarried adolescents actively seek information about sex, erotic pleasure and romance. Information was easily available from videos, mobile phone clips and pornographic magazines, but reinforced gender inequality. "Eve teasing" was one outlet for boys' sexual feelings; they gained pleasure from it and could show their masculinity. The girls disliked it and were afraid of being blamed for provoking it. Thus, "eve teasing" is a result of socio-cultural norms relating to sexuality, as well as a lack of access to sexual and reproductive health information and services in Bangladesh. These findings underscore the importance of comprehensive sexuality education that goes beyond a mere health focus and addresses gender norms and helps youth to gain social-sexual interaction skills. Copyright © 2013 Reproductive Health Matters. Published by Elsevier Ltd. All rights reserved.

  2. Rhabdovirus-like endogenous viral elements in the genome of Spodoptera frugiperda insect cells are actively transcribed: Implications for adventitious virus detection.

    Science.gov (United States)

    Geisler, Christoph; Jarvis, Donald L

    2016-07-01

    Spodoptera frugiperda (Sf) cell lines are used to produce several biologicals for human and veterinary use. Recently, it was discovered that all tested Sf cell lines are persistently infected with Sf-rhabdovirus, a novel rhabdovirus. As part of an effort to search for other adventitious viruses, we searched the Sf cell genome and transcriptome for sequences related to Sf-rhabdovirus. To our surprise, we found intact Sf-rhabdovirus N- and P-like ORFs, and partial Sf-rhabdovirus G- and L-like ORFs. The transcribed and genomic sequences matched, indicating the transcripts were derived from the genomic sequences. These appear to be endogenous viral elements (EVEs), which result from the integration of partial viral genetic material into the host cell genome. It is theoretically impossible for the Sf-rhabdovirus-like EVEs to produce infectious virus particles as 1) they are disseminated across 4 genomic loci, 2) the G and L ORFs are incomplete, and 3) the M ORF is missing. Our finding of transcribed virus-like sequences in Sf cells underscores that MPS-based searches for adventitious viruses in cell substrates used to manufacture biologics should take into account both genomic and transcribed sequences to facilitate the identification of transcribed EVE's, and to avoid false positive detection of replication-competent adventitious viruses. Copyright © 2016 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  3. Phenotypic variability in Meesmann's dystrophy

    DEFF Research Database (Denmark)

    Ehlers, Niels; Hjortdal, Jesper; Nielsen, Kim

    2008-01-01

    symptoms often include blurred vision and ocular irritation. Typical cases may be entirely free of complaints. Intermittent pain episodes, such as occur in recurrent erosion syndrome, are not the rule. Genetic sequencing indicated a familial relationship with the originally described Meesmann family......'s dystrophy occurs worldwide. The largest family described is the original German one, now supplemented with a Danish branch. Despite the presence of an identical genetic defect, the clinical phenotype varies. This suggests that non-KRT12-related mechanisms are responsible for the variation....

  4. ADEM – HAVVA – LİLİTH FİGÜRLERİ İZLEĞİNDE BİR OLANAKSIZLIK MİTİ: AŞK

    Directory of Open Access Journals (Sweden)

    Ender Ozbay

    2013-10-01

    Full Text Available "Love," the primary subject of art, also exhibits the characteristics of individual-social myth. The source of basic fact and concept of woman-man relationship to which "love" is related; the root and qualities of moral tradition and opinions can be seen from the "creation" narrations of holy books and various precepts. Some "creation" narration and myths tells about the creation of a woman named "Lilith" before Eve. In a creation story belonging to the 2000 BC, when she was first seen, Lilith, being the goddess of the matriarchal period and expelled from the patriarchal Sumerian world, is seen as an excluded character in the scripts of Cabala doctrines, too. In narrations and compositions, excluding the "powerful-subject" woman image from social life and rendering acceptable the woman identity which is dependent on a "power" composed of God-government-man, Lilith and Eve show mythological figure features symbolizing the opposite poles of woman identity and "morals. " In works of art performing the progressive events which come up with the persuasion of a living creature, which is the combination of snake-Devil-woman(Lilith in holy scripts, Eve about the "forbidden fruit", two characters are reflected with the imagery of contrasts representing hostility. In the descriptions of some works of art illustrating the art playing a part in the service of "gender ideology" and in modern digital-fantastic descriptions, a connection between the women and misdeed is made explicit with figures composed of snake-woman. Man gender of mankind building an ownership relation with the universe develops "dominance" in a more complicated way against its female and urged the woman to be either Lilith or Eve; and he was in the shadow of the unreal "power-strength" imagery. In the world shaped with "benefit values," "love," whose sides cannot be free-real subjects, has turned into an impossible myth, let alone being real.

  5. Professor Peep Veski meie meenutustes

    Index Scriptorium Estoniae

    2014-01-01

    Mälestusi Tartu Ülikooli Farmaatsia instituudi juhatajast Peep Veskist jagavad: Eve-Irene Lepist, Urve Paaver, Karin Kogermann, Kristian Semjonov, Jaak Koppel, Kristin Raudsepp, Imre Klebovich, Filiz Hincal, A. Atilla Hincal ja Elmar Arak

  6. Sotsiaalkapitali elemendid ja allikad / Eve Parts

    Index Scriptorium Estoniae

    Parts, Eve, 1970-

    2006-01-01

    Sotsiaalkapitali üksikute komponentide olemusest, alamliikidest, tekkemehhanismidest ja seostest, võimalustest sotsiaalkapitali sihipäraseks loomiseks majanduspoliitiliste meetmetega. Tabelid. Skeemid

  7. China on the eve of Copenhagen

    International Nuclear Information System (INIS)

    Niquet, V.

    2009-01-01

    The author first gives an overview of the Chinese worrying energy situation because of its high economic growth and its high energy demand and consumption. She highlights the preponderant share of coal and the associated environmental issues. She comments the economic and strategic implications of the oil share increase in energy consumption in China with respect to its energy supply security. She discusses the present debate on costs which would result from not taking environmental issues into account, and the weight of lobbies and local policies on these issues. Then, she notices that, however, significant evolutions can be observed in the Chinese environmental strategy: implemented policies and actions, research and development policy and investments. She discusses the consequences of these aspects and evolutions for the international negotiations in Copenhagen, and also the influence of the present economic and financial crisis on the Chinese environmental strategy

  8. Witches howl on New Year's Eve

    DEFF Research Database (Denmark)

    Grünbaum, Liselotte

    1997-01-01

    on the setting has to be picked up and contained both in the therapeutic relationship and in the network by teamwork, and b) by carefully following the child's movements in the transference relationship, the child can be helped to a dependent relationship inside which feelings can be made sense of....

  9. Tööstusomandi õiguskaitse / Eve Tang

    Index Scriptorium Estoniae

    Tang, Eve

    2005-01-01

    Nimestik Eesti tööstusomandi valdkonna õigusaktidest, Patendiameti ametlikest ja metoodilistest väljaannetest, on-line andmebaasidest. Lisatud tabel: Eesti Vabariigi ühinemine rahvusvaheliste lepingutega tööstusomandi valdkonnas

  10. Ryutaro - meie klassi jaapanlane / Eve Kukemelk

    Index Scriptorium Estoniae

    Kukemelk, Eve

    2011-01-01

    Tartu Miina Härma gümnaasiumis õppivast jaapani poisist Ryutaro Furukawa'st, kes tuli Eestisse koos oma eestlasest ema ja noorema vennaga pärast Fukushima tuumaelektrijaama katastroofi, maavärina ja tsunami üleelamist

  11. Multimeediaetendus : Opera Gets Plugged / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2008-01-01

    Eesti Muusika- ja Teatriakadeemia lühiooperite õhtul "Opera Gets Plugged" etendunud lavastustest - Monika Mattieseni "DMeeter" ja Age Hirve "Tuleloitsija": Mõlema lavastaja ja projektijuht Liis Kolle

  12. Noah and EVE (Environmental Values Education).

    Science.gov (United States)

    Knapp, Clifford

    1995-01-01

    Environmental ethics provide a set of related values that help to limit or restrict individual freedom in order to save and protect nature. Examples of environmental ethics include land ethics, deep ecology, social ecology, Native or first peoples' worldviews, reverence for life, and conservation and management. Includes teaching strategies and a…

  13. Aed: ajastatud = Garden: timed / Eve Komp

    Index Scriptorium Estoniae

    Komp, Eve, 1982-

    2013-01-01

    EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahenduses on iga avalik ruum ümber raekoja hoone kujundatud erinevalt, vastavalt päeva rütmile

  14. Painting radioprotection at the nuclear eve

    International Nuclear Information System (INIS)

    Portelli, Aurelien; Travadel, Sebastien; Guarnieri, Franck; Parizel, Claire

    2017-01-01

    The CEA Marcoule centre is one of the first pillar of the French nuclear industry. The radiation protection department (SPR) of the centre benefited from the artistic skill of Jacques Castan who illustrated the safety campaigns of the SPR since 1959 and fed an imagination about radiation protection. His most ambitious creation was a wall painting in a staircase, made in 1962. This article describes the symbolic meaning of this work of art, which is today missing

  15. Koit rikkus hea ajakirjandustava / Eve Rohtla

    Index Scriptorium Estoniae

    Rohtla, Eve, 1961-

    2007-01-01

    Ilmunud ka: Kesknädal, 11. apr. 2007, lk. 5. Pressinõukogu arutas Heimar Lengi kaebust ajalehes Koit 8.02. 2007 avaldatud valimisreklaami peale ning otsustas, et ajaleht rikkus head ajakirjandustava. Heimar Lenk polnud rahul, et tema tekst ei sisaldanud märget "Tasutud tekst", kuigi ta oli selle avaldamise eest ajalehele maksnud. Samuti polnud ta rahul, et tema reklaamteksti kohal oli teda halvustav lugejakiri

  16. Läänemere Agenda 21 haridusprogrammi töörühma koosolek / Olav Kruus

    Index Scriptorium Estoniae

    Kruus, Olav

    2001-01-01

    Tallinnasse kogunesid Läänemere Agenda 21 üldhariduse töörühma liikmed kümnest riigist 22.- 23. märtsil töökoosolekule, kuulati ära läbiviidud haridusalase küsitluse tulemused ning lepiti kokku haridusalase lõppdokumendi vormistamises, mille koostamiseks peavad riigid andma ülevaate säästva arengu põhimõtete kajastumisest hariduse eesmärkides ja sisus

  17. Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

    Directory of Open Access Journals (Sweden)

    Srovnal Josef

    2007-03-01

    Full Text Available Abstract Background Invasive ductal and lobular carcinomas (IDC and ILC are the most common histological types of breast cancer. Clinical follow-up data and metastatic patterns suggest that the development and progression of these tumors are different. The aim of our study was to identify gene expression profiles of IDC and ILC in relation to normal breast epithelial cells. Methods We examined 30 samples (normal ductal and lobular cells from 10 patients, IDC cells from 5 patients, ILC cells from 5 patients microdissected from cryosections of ten mastectomy specimens from postmenopausal patients. Fifty nanograms of total RNA were amplified and labeled by PCR and in vitro transcription. Samples were analysed upon Affymetrix U133 Plus 2.0 Arrays. The expression of seven differentially expressed genes (CDH1, EMP1, DDR1, DVL1, KRT5, KRT6, KRT17 was verified by immunohistochemistry on tissue microarrays. Expression of ASPN mRNA was validated by in situ hybridization on frozen sections, and CTHRC1, ASPN and COL3A1 were tested by PCR. Results Using GCOS pairwise comparison algorithm and rank products we have identified 84 named genes common to ILC versus normal cell types, 74 named genes common to IDC versus normal cell types, 78 named genes differentially expressed between normal ductal and lobular cells, and 28 named genes between IDC and ILC. Genes distinguishing between IDC and ILC are involved in epithelial-mesenchymal transition, TGF-beta and Wnt signaling. These changes were present in both tumor types but appeared to be more prominent in ILC. Immunohistochemistry for several novel markers (EMP1, DVL1, DDR1 distinguished large sets of IDC from ILC. Conclusion IDC and ILC can be differentiated both at the gene and protein levels. In this study we report two candidate genes, asporin (ASPN and collagen triple helix repeat containing 1 (CTHRC1 which might be significant in breast carcinogenesis. Besides E-cadherin, the proteins validated on tissue

  18. Guest editorial - Networked collaboration, sharing and response

    Directory of Open Access Journals (Sweden)

    Olav Skundberg

    2008-11-01

    Full Text Available  This issue of Seminar.net contains three articles that were written in connection with a Norwegian e-learning conference titled “Networked collaboration, sharing and response”. The conference was held in Mars 2008 in Trondheim, and the presentations from the conference is available (in norwegian language at http://www.nvu.no. Networked collaboration was chosen as a theme because collaboration is important to achieve learning, according to the social-constructivistic pedagogy that has a strong standing in Norway, but how should this occur on the net? Sharing of content, as in digital learning resources, is a phenomenon with increasing popularity as described in the OECD-report “Giving Knowledge for Free”. But to achieve reuse of content, not only publishing it, it is important with a networked community where the plethora of information can be sorted with relevance to specific topics. Response is about guiding, coaching and tutoring. In what ways may resources and tools be used to move in the direction of solving Bloom’s two sigma problem/challenge? The first article, by Morten Flate Paulsen, shows how cooperative learning can be implemented successfully so that students have optimal individual freedom within online learning communities. The second article, by Carl F. Dons, shows how student teachers can be prepared to deal with pupils who have a wide range of experiences of the digital world. The third and last article, by Kristin Dale, is sharing experiences with multiple choice-tests to give midterm responses to students. In addition, this issue has a commentary article by Rune Krumsvik discussing the need to develop new practices for teachers and students on the background of the digital developments. The conference and articles covers three big themes. It may be difficult to find more important issues, apart from finding money and time to support its development. Olav Skundberg, guest editorAssociate professor

  19. Relationship between self-reported pain sensitivity and pain after total knee arthroplasty: a prospective study of 71 patients 8 weeks after a standardized fast-track

    Directory of Open Access Journals (Sweden)

    Valeberg BT

    2016-09-01

    Full Text Available Berit T Valeberg,1 Lise H Høvik,2 Kari H Gjeilo3–6 1Faculty of Nursing, Oslo and Akershus University College of Applied Sciences, Oslo, 2Clinic of Anaesthesia and Intensive Care Medicine, St. Olavs Hospital, Trondheim University Hospital, 3Department of Cardiothoracic Surgery, 4Department of Cardiology, 5National Competence Centre for Complex Symptom Disorders, St. Olavs Hospital, Trondheim University Hospital, 6Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway Background and purpose: This was a prospective cohort study assessing data from 71 adult patients undergoing total knee arthroplasty (TKA following a standardized fast-track program between January and July 2013. The objective was to examine the relationship between self-rated pain sensitivity, as measured by the Pain Sensitivity Questionnaire (PSQ, and postoperative pain after TKA. Methods: The baseline questionnaires, PSQ and Brief Pain Inventory, were given to the patients for self-administration at the presurgical evaluation (1–2 weeks prior to surgery. The follow-up questionnaire, Brief Pain Inventory, was administered at the first follow-up, 8 weeks after surgery. Results: A statistically significant association was found between average preoperative pain and average pain 8 weeks after surgery (P=0.001. The PSQ-minor was statistically significantly associated with average pain only for patients younger than 70 years (P=0.03. Interpretation: This is the first study to examine the relationship between pain sensitivity measured by PSQ and postoperative pain in patients after TKA. We found that a lower score on the PSQ-minor was statistically significantly associated with patients’ pain 8 weeks after TKA surgery, but only for younger patients. Further research is needed to explore whether the PSQ could be a useful screening tool for patients’ pain sensitivity in clinical settings. Keywords

  20. 19. II esitas HULA Kanuti gildi vaatemängulist kostüümidraamat

    Index Scriptorium Estoniae

    2003-01-01

    Rõivakollektsiooni autorid on HULA loojad Reet Ulfsak, Marit Ahven, Anu Lensment, Eve Hanson ning külalistena Ruta Tepp, Ketlin Bachmann. HB kollektsiooni jaoks disainitud ehete autorid on Tanel Veenre, Andrus Rumm, Julia-Maria Pihlak

  1. Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies.

    Directory of Open Access Journals (Sweden)

    Bernhard Zatloukal

    Full Text Available The in situ proximity ligation assay (isPLA is an increasingly used technology for in situ detection of protein interactions, post-translational modifications, and spatial relationships of antigens in cells and tissues, in general. In order to test its performance we compared isPLA with immunofluorescence microscopy by analyzing protein interactions in cytoplasmic protein aggregates, so-called Mallory Denk bodies (MDBs. These structures represent protein inclusions in hepatocytes typically found in human steatohepatitis and they can be generated in mice by feeding of 3,5-diethoxy-carbonyl-1,4-dihydrocollidine (DDC. We investigated the colocalization of all three key MDB components, namely keratin 8 (K8, keratin 18 (K18, and p62 (sequestosome 1 by isPLA and immunofluorescence microscopy. Sensitivity and specificity of isPLA was assessed by using Krt8-/- and Krt18-/- mice as biological controls, along with a series of technical controls. isPLA signal visualization is a robust technology with excellent sensitivity and specificity. The biological relevance of signals generated critically depends on the performance of antibodies used, which requires careful testing of antibodies like in immunofluorescence microscopy. There is a clear advantage of isPLA in visualizing protein co-localization, particularly when antigens are present at markedly different concentrations. Furthermore, isPLA is superior to confocal microscopy with respect to spatial resolution of colocalizing antigens. Disadvantages compared to immunofluorescence are increased costs and longer duration of the laboratory protocol.

  2. A description of stress driven bubble growth of helium implanted tungsten

    International Nuclear Information System (INIS)

    Sharafat, Shahram; Takahashi, Akiyuki; Nagasawa, Koji; Ghoniem, Nasr

    2009-01-01

    Low energy (<100 keV) helium implantation of tungsten has been shown to result in the formation of unusual surface morphologies over a large temperature range (700-2100 deg. C). Simulation of these macroscopic phenomena requires a multiscale approach to modeling helium transport in both space and time. We present here a multiscale helium transport model by coupling spatially-resolved kinetic rate theory (KRT) with kinetic Monte Carlo (KMC) simulation to model helium bubble nucleation and growth. The KRT-based HEROS Code establishes defect concentrations as well as stable helium bubble nuclei as a function of implantation parameters and position from the implanted surface and the KMC-based Mc-HEROS Code models the growth of helium bubbles due to migration and coalescence. Temperature- and stress-gradients can act as driving forces, resulting in biased bubble migration. The Mc-HEROS Code was modified to simulate the impact of stress gradients on bubble migration and coalescence. In this work, we report on bubble growth and gas release of helium implanted tungsten W/O stress gradients. First, surface pore densities and size distributions are compared with available experimental results for stress-free helium implantation conditions. Next, the impact of stress gradients on helium bubble evolution is simulated. The influence of stress fields on bubble and surface pore evolution are compared with stress-free simulations. It is shown that near surface stress gradients accelerate helium bubbles towards the free surface, but do not increasing average bubble diameters significantly.

  3. Kõik sõltub meist endist / Loit Jõekalda

    Index Scriptorium Estoniae

    Jõekalda, Loit

    2000-01-01

    VI rahvusvahelisest Läänemere maade graafikabiennaalist "Kaliningrad-Königsberg 2000". Grand prix - Juho Karjalainen, kolm võrdset preemiat - Virge Jõekalda, Redas Dirzys, Andrei Kostin (postuumselt). Diplomi saanud kunstnikud. Osalejad (žüriis Eve Kask) Eestist.

  4. "OUT" elab edasi / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    1998-01-01

    "OUT'98". Kuraatorid Eve Kiiler, Piret Räni. Otsingutest videovallas (I. Helander, A. Nali, K. Sukmit, M. Laanemets, J. Zoova). Näidati ka Tokio vodeofestivalil hõbepreemia saanud R. Kelomehe videot "House". [þmobil]-galerii saatusest.

  5. Suur Teatriõhtu 2006 ehk Nike kliendikaardiga Vanapaganast, Eurovisioonile pääsenud vaeslapsest, roosades rõivastes printsist ja paljust muust

    Index Scriptorium Estoniae

    2006-01-01

    Kuressaare Gümnaasiumi Suurest Teatriõhtust. Ürituse üle mõtisklevad žürii liige Aarne Mägi, vilistlane Mihkel Miller, peakorraldaja Eve Paomees ja teatriõhtu traditsiooni looja ja ürituse peakorraldaja Marit Tarkin

  6. Saddam ootab hukkamist / Aadu Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Aadu, 1954-

    2006-01-01

    Apellatsioonikohus kinnitas endisele Iraagi diktaatorile Saddam Husseinile määratud surmaotsuse, andes selle täideviimiseks aega 30 päeva. Vt. samas: Eve Heinla, Urmo Soonvald. Ansip ja Paet: Eesti austab Iraagi kohtu otsust

  7. Conspicuous by Its Absence

    Institute of Scientific and Technical Information of China (English)

    JOSEPH; KIRSCHKE

    2010-01-01

    This year, I’m told, was a bit different:in the interest of not insulting millions of struggling Americans, Santa andhis reindeer touched down very lightly in the United States last month. New Year’sEve,

  8. Eesti Post sukeldub kiirlaenuärisse / Dannar Leitmaa

    Index Scriptorium Estoniae

    Leitmaa, Dannar, 1982-

    2008-01-01

    Eesti Post pakub katseprojekti raames isikusamasuse tuvastamise teenust viiele kiirlaenu pakkuvale firmale. Parlamendiliikmete Indrek Raudse ja Evelyn Sepa ning Tallinna Sotsiaaltöökeskuse sotsiaalteenuste osakonna juhataja Eve Võrgu kommentaarid. Lisa: Ministeerium: kõik on seaduslik

  9. Physics and Materials Science of High Temperature Superconductors

    Science.gov (United States)

    1989-08-26

    30 M. Nikolo: Effect of Texture and Density on Grain Coupling of Sintered Y-Ba-Cu-O Superconductors 11:30 - 12:00 A. SzAsz : The Symmetries and High...The Hall coefficient is always positive and obeys the RH (x T- 1 law . The I Hall mobility p2-I2 < I cm2/V.S. At T < Tc, the thermoelectric power equals...461561 80-6550 Prof. A. Szasz PP Dr. Martin Schwarz PP Eotvos University Angewandte Physik Muzeum Krt. 6-8 Hoechst AG H-1088 Budapest Hungary Gebaeude

  10. "Impact 4" Berliinis ja Poznanis / Vappu Thurlow

    Index Scriptorium Estoniae

    Thurlow, Vappu, 1960-

    2005-01-01

    5.-10. IX Berliinis ja Poznanis toimunud neljandast rahvusvahelisest graafikakonverentsist "Impact" alapealkirjaga "Kontakt". Eestist osalesid Loit Jõekalda, Eve Kask, Karin Laansoo ja Vappu Thurlow. 2007. a. Tallinnas toimuva "Impact 5", alapealkirjaga "Slices of Time/Lõigutud aeg", kontseptsioon

  11. Triennaali peaauhind läks Leetu

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna XIII graafikatriennaalil väljaantud preemiad: peaauhind - leedu graafik Egle Kuckaite, diplomid - eesti kunstirühmitus John Smith (projekt betoonkohvritega "100 John Smithi") ja Eve Kiiler (fotoseeria "Fantastiline realism"), kiituskiri - eesti rühmitus Anonymous Boh

  12. 20. VI avatakse EKA galeriis rahvusvaheline fotonäitus "Fragile Distance"

    Index Scriptorium Estoniae

    2003-01-01

    Kuraatorid David Bate, Eve Kiiler. Osalevad Londonis elavad ja töötavad fotograafid Denny Robson, Adam Green, Michelle Atherton (Inglismaa), Eva Riegler (Austria), Andreas Hablutzel (Šveits), Angeliki Douveri, Stella Baraklianou (Kreeka), Simona Dell'Agli (Itaalia)

  13. Põhjamaade ehtekunst

    Index Scriptorium Estoniae

    2002-01-01

    Tarbekunstimuuseumis II Põhjamaade ehtekunsti triennaal. Kujundaja Castello Hansen. Eesti ehtekunsti esindavad Piret Hirv, Eve Margus Villems, Maria Valdma, valiku pani kokku Kadri Mälk. Uuenduseks ühe klassiku, rootsi kunstniku Torun Bülow Hübe loomingu eksponeerimine

  14. Milline on edukas teatri ja lavastuste kommunikatsioon? / Piret Jaaks

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2015-01-01

    Kommunikatsioonist Eesti teatrites. Kogemusi jagavad Kristo Kruusman Rakvere teatrist, Kätlin Sumberg Teatrist NO99, Ruudu Raudsepp Linnateatrist, Eveli Loorents Endla teatrist, Hannele Känd Nukuteatrist, Herkko Labi Von Krahli teatrist ja väiketeater Cabaret Rhizome

  15. Ida-Euroopa kunst Londonis

    Index Scriptorium Estoniae

    2011-01-01

    Eve Kase kureeritud näitus "Memoirs from a Cold Utopia" Londonis 28. juulist 28. novembrini 2011. Näitus tähistab Nõukogude Liidu lagunemise 20. aastapäeva. Eestist osalevad Marko Mäetamm, Anu Juurak, Tanja Muravskaja

  16. 23. IV avati EKA galeriis projekti "Network Baltic" laureaatide graafikanäitus

    Index Scriptorium Estoniae

    2003-01-01

    Rahvusvahelise kunstiprojekti "Network Baltic - a new dimension" algatas Grafikenshus Rootsis Mariefredis, Eestist osaleb EKA graafikaosakond, kuraator - Enno Ootsing. Näitusel esinevad Kevin Lytsen Taanist, Kaija Kesa Soomest, internetikonkursil ära märgitud Helen Tago ja Eveli Varik

  17. Cardiovascular hospitalizations and associations with environmental quality

    Science.gov (United States)

    Cardiovascular disease has been identified as a condition that may be associated with environmental factors. Air pollution in particular has been demonstrated to be associated with cardiovascular disease and atherosclerosis, which can increase the likelihood of cardiovascular eve...

  18. Kati Tolmoff: linn peabki oma sportlasi toetama / Maili Kangur

    Index Scriptorium Estoniae

    Kangur, Maili

    2009-01-01

    Tartlasest sulgpallur Kati Tolmoff sai Tartu Kultuurkapitali poolt olümpialootuse stipendiumi. Stipendiumi said ka Peeter Kümmel, Eveli Saue, Kristjan Kais, Rivo Vesik, Sirkka-Liisa Kivine, Tiidrek Nurme, Kaire Leibak, Künter Rothberg ja Maris Mägi

  19. Fluorescence Sensors for Early Detection of Nitrification in Drinking Water Distribution Systems – Interference Corrections (Poster)

    Science.gov (United States)

    Nitrification event detection in chloraminated drinking water distribution systems (DWDSs) remains an ongoing challenge for many drinking water utilities, including Dallas Water Utilities (DWU) and the City of Houston (CoH). Each year, these utilities experience nitrification eve...

  20. Fluorescence Sensors for Early Detection of Nitrification in Drinking Water Distribution Systems – Interference Corrections (Abstract)

    Science.gov (United States)

    Nitrification event detection in chloraminated drinking water distribution systems (DWDSs) remains an ongoing challenge for many drinking water utilities, including Dallas Water Utilities (DWU) and the City of Houston (CoH). Each year, these utilities experience nitrification eve...

  1. Kaarma Bold Italic / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-

    2000-01-01

    Raamatukujundajast Jüri Kaarmast ja tema loomingust. Kommenteerib abikaasa Eve Kask. J. Kaarma sellest, miks temast sai raamatukujundaja, oma parimatest õpetajatest (E. Kärmas, I. Paul), töömeetodist, loomingust, uue kirjatüübi konstrueerimisest jm

  2. Kaarma Bold Italic / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-

    2011-01-01

    Raamatukujundajast Jüri Kaarmast ja tema loomingust. Kommenteerib abikaasa Eve Kask. J. Kaarma sellest, miks temast sai raamatukujundaja, oma parimatest õpetajatest (E. Kärmas, I. Paul), töömeetodist, loomingust, uue kirjatüübi konstrueerimisest jm

  3. Securing Communication via Transmission of Artificial Noise by Both Sides: Bipolar-Beamforming Optimization

    Directory of Open Access Journals (Sweden)

    Yongkai Zhou

    2013-01-01

    Full Text Available The paper considers the secure transmission in a wireless environment in which both the transmitter (Alice and the legitimate receiver (Bob send artificial noise (AN to interfere with the eavesdropper (Eve. Optimal design is analyzed in detail for this AN-by-both-side model to deal with Eve’s stochastic channel condition and random spatial distribution. Bipolar-beamforming is first proposed to jointly design Alice and Bob’s transmitting signals. By optimally assigning the transmitting antenna for Bob and allocating the power ratio between Alice’s information and the AN signal, maximum secrecy capacity can be achieved. Simulation is done to illustrate the process of bipolar-beamforming optimization. Results show that the AN-by-both-side model has good secrecy performance on both average and extreme conditions as Eve approaches Alice or Bob.

  4. Intrinsic imperfection of self-differencing single-photon detectors harms the security of high-speed quantum cryptography systems

    Science.gov (United States)

    Jiang, Mu-Sheng; Sun, Shi-Hai; Tang, Guang-Zhao; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei

    2013-12-01

    Thanks to the high-speed self-differencing single-photon detector (SD-SPD), the secret key rate of quantum key distribution (QKD), which can, in principle, offer unconditionally secure private communications between two users (Alice and Bob), can exceed 1 Mbit/s. However, the SD-SPD may contain loopholes, which can be exploited by an eavesdropper (Eve) to hack into the unconditional security of the high-speed QKD systems. In this paper, we analyze the fact that the SD-SPD can be remotely controlled by Eve in order to spy on full information without being discovered, then proof-of-principle experiments are demonstrated. Here, we point out that this loophole is introduced directly by the operating principle of the SD-SPD, thus, it cannot be removed, except for the fact that some active countermeasures are applied by the legitimate parties.

  5. Official holidays in 2013 and end-of-year closure 2013/2014 (Application of Articles R II 4.38 and R II 4.39 of the Staff Regulations)

    CERN Multimedia

    2013-01-01

    Official holidays in 2013 (in addition to the special leave during the annual closure): Tuesday, 1 January (New Year) Friday, 29 March (Good Friday) Monday, 1 April (Easter Monday) Wednesday, 1 May                    Thursday, 9 May (Ascension day) Monday, 20 May (Whit Monday) Thursday, 5 September (Jeûne genevois) Tuesday, 24 December (Christmas Eve) Wednesday, 25 December (Christmas Day) Tuesday, 31 December (New Year’s Eve)   Annual closure of the site of the Organization during the Christmas holidays and day of special leave granted by the Director-General: The Laboratory will be closed from Saturday, 21 December 2013 to Sunday, 5 January 2014 inclusive (without deduction of an...

  6. Triumfalnoje vozvrashtshenije 60-h / Airika Soome, Jaanika Sootna, Merike Pääro...[jt.] ; interv. Valeria Aru

    Index Scriptorium Estoniae

    2007-01-01

    Eesti tuntuimate kaubamärkide PTA, Monton, Bastion, Ivo Nikkolo ja Mosaic moekunstnike nägemused moest kevad-suveks 2007. PTA - Airika Soome, Monton - Jaanika Sootna, Bastion - Merike Pääro, Ivo Nikkolo - Eve Hanson ja Mosaic - Evelin Lill

  7. Quaestiones Mathematicae - Vol 32, No 2 (2009)

    African Journals Online (AJOL)

    Into isomorphisms in tensor products of Banach spaces · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Eve Oja, Vaiki Randala. http://dx.doi.org/10.2989/QM.2009.32.2.9.802 ...

  8. Kontseptsioonid ja persoonid / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    2003-01-01

    Heli Sarapuu näitus "Isale" Hobusepea galeriis. Valeri Vinogradovi "Design Jet 5001" Viviann Napi Galeriis. Eve Kiileri "Progressi arhitektoonika" Tallinna Linnagaleriis. Jan Van Imschooti maalinäitus "Müstilised patud ja kaasaegsed värvid. Ümberhindamise asupaik"

  9. Kas alternatiivid mainstreamil või alternatiivne mainstream? / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1998-01-01

    Missugune on praeguste eesti noorte sub- ja kontrakultuur? Samasuguseid laineid on enne olnud, näiteks Lapin-Okas-Keskküla, Eve ja Peeter Linnap & jüngrid. Hanno Soansi kutse väljuda galeriidest ja mõjutama olmet.

  10. Taastatud Jaani kiriku interjöörid 21. sajandi kontekstis / Krista Kodres

    Index Scriptorium Estoniae

    Kodres, Krista, 1957-

    2006-01-01

    Tartu Jaani kiriku interjööridest. Kunstiajaloolane Kaur Alttoa. Sisekujundajad: Tea Tammelaan, Malle Jürgenson, Krista Lepland. Terrakotaskulptuure on konserveerinud, algul koos sakslastega (Sven Wallasch, keemik Eberhard Wendler), Eve Alttoa. Fassaadiskulptuuride koopiad valmistab Isabel Aaso. Ka Urmo Rausi akendeprojektist

  11. Reliikvia 33 aastat hiljem / Piret Tali

    Index Scriptorium Estoniae

    Tali, Piret, 1972-

    2002-01-01

    Soomes restaureeritud eesti menufilmi "Viimne reliikvia" (1969) taas Eestis ekraanile jõudmise eel korraldatud pressikonverentsilt Coca-Cola Plazas, kus kohal filmis osalenud näitlejad Ingrida Andrina, Aleksandr Goloborodko, Eve Kivi ja Uldis Vazdik, stsenarist Arvo Valton ja kunstnik Rein Raamat

  12. Rein Raua kuraatoridebüüt

    Index Scriptorium Estoniae

    2001-01-01

    Hausi galeriis Rein Raua kureeritud rahvusvaheline kunstinäitus "KevadSuviSügisTalv. Murdumispunkt". Esinevad Eve Kask, Peeter Laurits, Dainius Lickevicius, Rehka Menon, Mall Nukke, Herkki Merila, Jorma Puranen, Rosita Raud, Ene-Liis Semper, Liina Siib, S. ja P. Stanikas

  13. TPÜ Akadeemilise Raamatukogu ajaloolised kogud rahvusvahelistes infoallikates / Tiiu Reimo

    Index Scriptorium Estoniae

    Reimo, Tiiu, 1953-

    2005-01-01

    Lk. 99 mainitud : Urve Lõhmus, Voldemar Miller, Tiiu Reimo; lk. 100 : Voldemar Miller, Kyra Robert; lk. 102 : Tiiu Reimo, Medea Jerser, Toomas Raudam; lk. 103 : Antti Oviir, Aita Jõulu; lk. 104 : Tiiu Reimo, Marita Paas, Mati Merioja, Tiiu Pukk, Eve Roosileht

  14. Näitus kui publiku-uuring / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2008-01-01

    Eve Kiileri näitus "Muuseumilabor" Tallinna Kunstihoone galeriis 26. IX-19. X. Tutvuda saab Kiasmas, Kumus, Briti Muuseumis, Palais de Tokyos, Hamburger Bahnhofis, Vatikani muuseumis, Veneetsia biennaalil läbi viidud publiku-uuringute tulemustega. Publikuteemaline seminar-ümarlaud 16. X

  15. Eesti kirjandus 1997

    Index Scriptorium Estoniae

    1998-01-01

    Aut.: Märt Väljataga, Mart Velsker, Barbi Pilvre, Indrek Särg, Tarmo Vahter, Piret Viires, Tõnu Kaalep, Janika Kronberg, Lauri Sommer, Sven Kivisildnik, Eve Annuk, Aarne Ruben, Jan Kaus, Karl Martin Sinijärv, Jüri Ehlvest, Hasso Krull

  16. Saaremaa biennaal on pääsenud maailma kunstiajalukku

    Index Scriptorium Estoniae

    1999-01-01

    Oxford University Press'is ilmunud entsüklopeedia "Encyclopedia of Aesthetics" toob kahel korral ära Saaremaa biennaali. Artikli "The Postmodern Transformation of Art" on kirjutanud ameerika kunstiteadlane Thomas McEvilley. Saarema biennaali algatasid 1995. a. Peeter Linnap ja Eve Kiiler.

  17. Vaatamisest teateni / Margot Kask

    Index Scriptorium Estoniae

    Kask, Margot

    2006-01-01

    Maastiku mõiste arengust läbi kunstiajaloo ning nägemise ja kujutamise vastastikustest seostest. Reimo Võsa Tangsoo (sünd. 1976), Eve Kiileri (sünd. 1962), Ivar Veermäe (sünd. 1982) ja Taavi Suitsu maastikufotodest

  18. Kontsert : Hardi Volmer hakkab loitsima. Kuus stiilset kontsertetendust

    Index Scriptorium Estoniae

    2008-01-01

    Kontserdist "Tõrva loits" 16. aug. Tõrvas. 15.-24. augustini annab kontserdisarjas "Eesti mõisad 2008" kuus kontsertetendust barokkmuusika ansambel Corelli Consort (vt. www.corelli.ee), kontsertetenduste kostüümid on loonud Ivo Nikkolo brändi naisteriiete peadisainer Eve Hanson

  19. Expression of SMAD signal transduction molecules in the pancreas

    DEFF Research Database (Denmark)

    Brorson, Michael; Hougaard, D.; Nielsen, Jens Høiriis

    2001-01-01

    Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eve...

  20. Exome analysis in clinical practice: expanding the phenotype of Bartsocas-Papas syndrome.

    Science.gov (United States)

    Gripp, Karen W; Ennis, Sara; Napoli, Joseph

    2013-05-01

    Exome analysis has had a dramatic impact on genetic research. We present the application of such newly generated information to patient care. The patient was a female, born with normal growth parameters to nonconsanguineous parents after an uneventful pregnancy. She had bilateral cleft lip/palate and ankyloblepharon. Sparse hair, dysplastic nails and hypohidrosis were subsequently noted. With exception of speech related issues, her development was normal. A clinical diagnosis of ankyloblepharon-ectodermal defects-cleft lip/palate or Hay-Wells syndrome resulted in TP63 sequence analysis. TP63 sequence and deletion/duplication analysis of all coding exons had a normal result, as did chromosome and SNP array analysis. Diagnostic exome analysis revealed a heterozygous nonsense mutation in KRT83 categorized as deleterious and associated with monilethrix. In addition, a homozygous missense variant of unknown clinical significance was reported in RIPK4. Using research based exome analysis, RIPK4 had just a few months prior been identified as pathogenic for Bartsocas-Papas syndrome. While the clinical diagnostic report implied the KRT83 mutation as a more likely cause for the patient's phenotype, clinical correlation, literature review and use of computerized mutation analysis programs allowed us to identify the homozygous RIPK4 (c.488G > A; p.Gly163Asp) mutation as the underlying pathogenic change. Consequently, we expand the phenotype of Bartsocas-Papas syndrome to an attenuated presentation resembling Hay-Wells syndrome, lacking lethality and pterygia. In contrast to the autosomal dominant Hay-Wells syndrome, Bartsocas-Papas syndrome is autosomal recessive, implying a 25% recurrence risk. Copyright © 2013 Wiley Periodicals, Inc.

  1. Under-recognition of acral peeling skin syndrome: 59 new cases with 15 novel mutations.

    Science.gov (United States)

    Szczecinska, W; Nesteruk, D; Wertheim-Tysarowska, K; Greenblatt, D T; Baty, D; Browne, F; Liu, L; Ozoemena, L; Terron-Kwiatkowski, A; McGrath, J A; Mellerio, J E; Morton, J; Woźniak, K; Kowalewski, C; Has, C; Moss, C

    2014-11-01

    Acral peeling skin syndrome (APSS) is a rare skin fragility disorder usually caused by mutations in the transglutaminase 5 gene (TGM5). We investigated the mutation spectrum of APSS in the U.K., Germany and Poland. We identified 59 children with APSS from 52 families. The phenotype was readily recognizable, with some variation in severity both within and between families. Most cases had been misdiagnosed as the localized form of epidermolysis bullosa simplex (EBS-loc). Eighteen different TGM5 mutations were identified, 15 of which were novel. Eight mutations were unique to a single family, nine each occurred in two families, while the common p.Gly113Cys mutation linked to a second missense variant p.Thr109Met occurred in 47 of the 52 families and was homozygous in 28. Most patients were of nonconsanguineous white European origin. We propose that APSS is under-reported and widely misdiagnosed as EBS-loc, with significant counselling implications as APSS is autosomal recessive while EBS-loc is dominant. We recommend screening for TGM5 mutations when EBS-loc is suspected but not confirmed by mutations in KRT5 or KRT14. Our report trebles the number of known TGM5 mutations. It provides further evidence that p.Gly113Cys is a founder mutation in the European population. This is consistent with the striking ethnic distribution of APSS in U.K., where the majority of patients are of nonconsanguineous white European origin, in contrast to the pattern of other recessive skin disorders. © 2014 British Association of Dermatologists.

  2. Preemiad

    Index Scriptorium Estoniae

    2003-01-01

    Mark Soosaare filmile "Anu Raud - elumustrid" Kuldmüüri 3. preemia Itaalias, Eve Kase digitaaltrükile "Üks küla" Deutsche Bank'i auhind, Heie Treierile Ervin Pütsepa kunstiteaduse aastapreemia monograafia "Pärsimägi. Võrumaa-Tartu-Pariis"

  3. Opstandingsverhale en opstandingsdogma

    African Journals Online (AJOL)

    Test

    7 Jun 2011 ... mag oor mense se lewens en denke gegee het. Augustinus. (354–430) ... Fall, engineered by Adam and Eve; Redemption wrought by the self-sacrificing death of ... has met the fate of the Berlin Wall' (Kennedy 2006:252). Ons.

  4. "Krasnaja gvozdika - sputnitsa trevog, krasnaja gvozdika - nash tsvetok"

    Index Scriptorium Estoniae

    2001-01-01

    Kommentaarid Mart Laari lillevalikule uue presidendi õnnitlemisel. Pealk. ajalehes Molodjozh Estonii : Subbota (2001/Sep/29) lk. 8: "I gde tolko Laar vzjal eti tsvetõ?". Refereeritud Eve Heinla artiklit "Kust küll Laar need lilled sai?", Õhtuleht (2001/Sep/25)

  5. Kirjad Paduasse / Marijke Vallanzasca ; tõlkinud Mart Rummo

    Index Scriptorium Estoniae

    Vallanzasca, Marijke

    2010-01-01

    Eesti ehtekunstinäitus Marijke Studios Paduas 23. 04.-30. 06. 2010. 17 osalejat loetletud. Eksponeeritud oli 69 ehteobjekti, ilmus kataloog. Kadri Mälgu, Piret Hirve, Tanel Veenre, Villu Plingi, Eve Margus-Villemsi, Kristiina Kibe ja Kertu Tubergi töödest

  6. Täna kell 18 on Tallinna Kinomajas filmiõhtu...

    Index Scriptorium Estoniae

    2005-01-01

    Näidatakse Eesti Kunstnike Liidu tellimusel 2005. a. valminud kunstnike-teemalisi filme: Marko Raadi filmi "F.F.F.F. läheb laiali" (Kuukulgur Film), Anri Rulkovi filmi Mare Vindist (Exitfilm), Eve Esteri ja Igor Ruusi filmi Jaan Klõsheikost (Estonia Film)

  7. Ehtekunstnikud Genfis

    Index Scriptorium Estoniae

    2002-01-01

    Eesti Kunstiakadeemia ehteväljapanek kõrgkoolide ehetekunstiüliõpilaste suursündmusel "L'ornament est-il toujours un crime?". Eksponeeritud Tanel Veenre, Bruno Lillemetsa, Julia Maria Pihlaku, Kertu Tubergi, Villu Plingi, Piret Hirve ja Eve Margus-Villemsi tööd

  8. Official holidays in 2014 and end-of-year closure 2014/2015

    CERN Multimedia

    2014-01-01

    (Pursuant to Articles R II 4.38 and R II 4.39 of the Staff Regulations)   Official holidays in 2014 (in addition to special leave during the annual closure): Wednesday, 1 January (New Year) Friday, 18 April (Good Friday) Monday, 21 April (Easter Monday) Thursday, 1 May Thursday, 29 May (Ascension day) Monday, 9 June (Whit Monday) Thursday, 11 September ("Jeûne genevois") Wednesday, 24 December (Christmas Eve) Thursday, 25 December (Christmas) Wednesday, 31 December (New Year’s Eve)   Annual closure of the site of the Organization during the Christmas holidays and day of special leave granted by the Director-General: The Laboratory will be closed from Saturday, 20 December 2014 to Sunday, 4 January 2015 inclusive (without deduction of annual leave). The first working day in the New Year will be Monday, 5 January 2015. Human Resources Department Tel. 73903/79257

  9. Quantum key distribution using continuous-variable non-Gaussian states

    Science.gov (United States)

    Borelli, L. F. M.; Aguiar, L. S.; Roversi, J. A.; Vidiella-Barranco, A.

    2016-02-01

    In this work, we present a quantum key distribution protocol using continuous-variable non-Gaussian states, homodyne detection and post-selection. The employed signal states are the photon added then subtracted coherent states (PASCS) in which one photon is added and subsequently one photon is subtracted from the field. We analyze the performance of our protocol, compared with a coherent state-based protocol, for two different attacks that could be carried out by the eavesdropper (Eve). We calculate the secret key rate transmission in a lossy line for a superior channel (beam-splitter) attack, and we show that we may increase the secret key generation rate by using the non-Gaussian PASCS rather than coherent states. We also consider the simultaneous quadrature measurement (intercept-resend) attack, and we show that the efficiency of Eve's attack is substantially reduced if PASCS are used as signal states.

  10. Effect of imperfect Faraday mirrors on the security of a Faraday–Michelson quantum cryptography system

    International Nuclear Information System (INIS)

    Wang, Wei-Long; Gao, Ming; Ma, Zhi

    2013-01-01

    The one-way Faraday–Michelson system is a very useful practical quantum cryptography system where Faraday mirrors (FMs) play an important role. In this paper we analyze the security of this system against imperfect FMs. We consider the security loophole caused by imperfect FMs in Alice’s and Bob’s security zones. Then we implement a passive FM attack in this system. By changing the values of the imperfection parameters of Alice’s FMs, we calculate the quantum bit error rate between Alice and Bob induced by Eve and the probability that Eve obtains outcomes successfully. It is shown that the imperfection of one of Alice’s two FMs makes the system sensitive to an attack. Finally we give a modified key rate as a function of the FM imperfections. The security analysis indicates that both Alice’s and Bob’s imperfect FMs can compromise the secure key. (paper)

  11. Secrecy extraction from no-signaling correlations

    International Nuclear Information System (INIS)

    Scarani, Valerio; Gisin, Nicolas; Brunner, Nicolas; Masanes, Lluis; Pino, Sergi; Acin, Antonio

    2006-01-01

    Quantum cryptography shows that one can guarantee the secrecy of correlation on the sole basis of the laws of physics, that is, without limiting the computational power of the eavesdropper. The usual security proofs suppose that the authorized partners, Alice and Bob, have a perfect knowledge and control of their quantum systems and devices; for instance, they must be sure that the logical bits have been encoded in true qubits and not in higher dimensional systems. In this paper, we present an approach that circumvents this strong assumption. We define protocols, both for the case of bits and for generic d-dimensional outcomes, in which the security is guaranteed by the very structure of the Alice-Bob correlations, under the no-signaling condition. The idea is that if the correlations cannot be produced by shared randomness, then Eve has poor knowledge of Alice's and Bob's symbols. The present study assumes on the one hand that the eavesdropper Eve performs only individual attacks (this is a limitation to be removed in further work), and on the other hand that Eve can distribute any correlation compatible with the no-signaling condition (in this sense her power is greater than what quantum physics allows). Under these assumptions, we prove that the protocols defined here allow extracting secrecy from noisy correlations, when these correlations violate a Bell-type inequality by a sufficiently large amount. The region in which secrecy extraction is possible extends within the region of correlations achievable by measurements on entangled quantum states

  12. Ionospheric Change and Solar EUV Irradiance

    Science.gov (United States)

    Sojka, J. J.; David, M.; Jensen, J. B.; Schunk, R. W.

    2011-12-01

    The ionosphere has been quantitatively monitored for the past six solar cycles. The past few years of observations are showing trends that differ from the prior cycles! Our good statistical relationships between the solar radio flux index at 10.7 cm, the solar EUV Irradiance, and the ionospheric F-layer peak density are showing indications of divergence! Present day discussion of the Sun-Earth entering a Dalton Minimum would suggest change is occurring in the Sun, as the driver, followed by the Earth, as the receptor. The dayside ionosphere is driven by the solar EUV Irradiance. But different components of this spectrum affect the ionospheric layers differently. For a first time the continuous high cadence EUV spectra from the SDO EVE instrument enable ionospheric scientists the opportunity to evaluate solar EUV variability as a driver of ionospheric variability. A definitive understanding of which spectral components are responsible for the E- and F-layers of the ionosphere will enable assessments of how over 50 years of ionospheric observations, the solar EUV Irradiance has changed. If indeed the evidence suggesting the Sun-Earth system is entering a Dalton Minimum periods is correct, then the comprehensive EVE solar EUV Irradiance data base combined with the ongoing ionospheric data bases will provide a most fortuitous fiduciary reference baseline for Sun-Earth dependencies. Using the EVE EUV Irradiances, a physics based ionospheric model (TDIM), and 50 plus years of ionospheric observation from Wallops Island (Virginia) the above Sun-Earth ionospheric relationship will be reported on.

  13. Quantum hacking on a practical continuous-variable quantum cryptosystem by inserting an external light

    Science.gov (United States)

    Qin, Hao; Kumar, Rupesh; Alleaume, Romain

    2015-10-01

    We report here a new side channel attack on a practical continuous-variable (CV) quantum key distribution (QKD) system. Inspired by blinding attack in discrete-variable QKD, we formalize an attack strategy by inserting an external light into a CV QKD system implemented Gaussian-modulated coherent state protocol and show that our attack can compromise its practical security. In this attack, we concern imperfections of a balanced homodyne detector used in CV QKD. According to our analysis, if one inserts an external light into Bob's signal port, due to the imperfect subtraction from the homodyne detector, the leakage of the external light contributes a displacement on the homodyne signal which causes detector electronics saturation. In consequence, Bob's quadrature measurement is not linear with the quadrature sent by Alice. By considering such vulnerability, a potential Eve can launch a full intercept-resend attack meanwhile she inserts an external light into Bob's signal port. By selecting proper properties of the external light, Eve actively controls the induced displacement value from the inserted light which results saturation of homodyne detection. In consequence, Eve can bias the excess noise due to the intercept-resend attack and the external light, such that Alice and Bob believe their excess noise estimation is below the null key threshold and they can still share a secret key. Our attack shows that the detector loopholes also exist in CV QKD, and it seems influence all the CV QKD systems using homodyne detection, since all the practical detectors have finite detection range.

  14. Area Handbook for Guinea. Second Edition

    Science.gov (United States)

    1975-01-01

    227. 283; and defense assistance, 320, 341 I Eisenhower. Dwight D.: 194 [elders me almt social system): 79. fS. 103; j council« of. 81, 85; and... almt eiectricity): 6. ! 41, 46. 55. 2«t. 291; dams. 289; Konkourp i pn>ject. 223; potential, 273, 277. 28» | lie de Goree: 17. 20 | lies de...375 Prui. 8S tivMtwk itre almt emk-, hc-niing. nu-mt »upplyi; !«»-10l. 245. 253. 2S4, 30*26»; fhM-krt». IS*: fcncm». H»-I«i; «wit*. 1», 253. 3

  15. Eesti foto näitus panustab pealetulijaile / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2004-01-01

    Eesti kaasaegse foto konkursinäitus "Eesti Foto 2004" Pärnu Uue Kunsti Muuseumis. Grand Prix saanud Ove Maidla, I - III preemia laureaaatide Kristo Rihma, Anu Vahtra ja Märten Krossi töödest. Eripreemiate saajad on Andras Kralla, Eveli Varik ja Malev Toom

  16. Periperformative Life Narrative: Queer Collages

    NARCIS (Netherlands)

    Poletti, A.L.|info:eu-repo/dai/nl/377063525

    2016-01-01

    This essay reconsiders the importance of performativity to scholarship on life writing by exploring the potential of Eve Sedgwick's concept of the periper-formative utterance for reading queer life narratives. Taking the documentary Tarnation (2003) as an example, I argue that a range of life

  17. Kontrastõ ot Baltika Grupp / Jana Kuvaitseva

    Index Scriptorium Estoniae

    Kuvaitseva, Jana

    2007-01-01

    Eesti rõivatootja Baltika Grupp uutest sügis-talvistest kollektsioonidest räägivad Montoni kaubamärgi disainerid Jaanika Sootna ja Evelin Lill ning Ivo Nikkolo kaubamärgi disainer Eve Hanson. Baltika kaubamärgid on Monton, Mosaic, Baltman ja Ivo Nikkolo

  18. 1 küsimus noorele juhile : Kuidas on kõige parem tähtsad põhimõtted töötajateni viia? / Kaarel Oja, Reet Roos, Martin Hurt... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad Teater NO99 tegevjuht Kaarel Oja, meediaagentuuri Inspired, tööõigusbüroo ja trükikoja Digiprint omanik Reet Roos, kaitseministeeriumi asekantsler Martin Hurt, SOL Eesti personalijuht Evely Ellert ning investeerimis- ja varahalduslahendusi pakkuva Sampo Life juhatuse liige Erkki Sadam

  19. Klõsheiko, Mare Vint, effid / Harry Liivrand

    Index Scriptorium Estoniae

    Liivrand, Harry, 1961-

    2005-01-01

    Tallinna Kinomajas esilinastusid 28. okt. kolm uut dokumentaalfilmi eesti kunstnikest : "F.F.F.F. läheb laiali" (Kuukulgur Film 2005, rezh. Marko Raat, "Mare Vint" (Exitfilm 2005, rezh. Anri Rulkov) ja "Jaan Klõsheiko" (Estonia Film 2005, rezh.-d Eve Ester, Igor Ruus)

  20. Kunstnike liidu tellimusel on valminud kolm uut kunstifilmi / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2005-01-01

    Kolm uut dokumentaalfilmi eesti kunstnikest, mis valminud Eesti Kunstnike Liidu tellimusel : "F.F.F.F. läheb laiali" (Kuukulgur Film 2005, rezh. Marko Raat), "Mare Vint" (Exitfilm 2005, rezh. Anri Rulkov) ja "Jaan Klõsheiko" (Estonia Film 2005, rezh.-d Eve Ester, Igor Ruus)

  1. [History and evolution of the organization of health care in prisons].

    Science.gov (United States)

    Bodon-Bruzel, Magali

    2013-03-01

    It was on the eve of the French Revolution, with the trend for health and philanthropy, that the focus on the health of prisoners, including their mental health, started to evolve. However, psychiatric care for prisoners only became widespread after the Second World War.

  2. Eesti ehe Hollandis

    Index Scriptorium Estoniae

    1999-01-01

    12. dets.-ni Hollandis, Nijmegeni linnas Galeerie Marzees noorte eesti ehtekunstnike näitus 'Õhu lossid', mida on spondeerinud ka Charon Kransen New Yorgist. Esinevad Tanel Veenre, Katrin Sipelgas, Villu Plink, Kristiina Laurits, Piret Hirv, Eve Margus ning õppejõud Kadri Mälk

  3. Täna kell 17.30 avatakse Tallinna Kunstihoones briti, eesti ja soome fotonäitus "Fantastiline realism"

    Index Scriptorium Estoniae

    2004-01-01

    Kuraator Eve Kiiler. Osalejad loetletud. Avamisel esineb Naeruorgesster. 28. II seminaril räägib Asko Mäkela soome fotokunstist, David Bate briti fotost, Mike Marshall, Denny Robson, Outi Liusvaara, Marja Pirilä, Kai Kaljo ja Piret Räni presenteerivad oma töid

  4. Marie Skoldowska Curie

    Indian Academy of Sciences (India)

    editors

    She found that for a given amount of active material, the current increased with the plate ... In the words of their daughter Eve Curie “they began ... Although it was similar to barium in its chemical properties, its chloride was less soluble in water.

  5. Wound complications and surgical events in de novo heart transplant patients treated with everolimus

    DEFF Research Database (Denmark)

    Rashidi, Mitra; Esmaily, Sorosh; Fiane, Arnt E

    2016-01-01

    OBJECTIVES: The use of mammalian target of rapamycin (mTOR) inhibitors have been limited by adverse events (AE), including delayed wound healing. We retrospectively reviewed all AE and serious AE (SAE) in The Scandinavian heart transplant (HTx) everolimus (EVE) de novo trial with early calcineurin...

  6. Eesti panusest projektis "Education 2030" / Eve Kikas

    Index Scriptorium Estoniae

    Kikas, Eve, 1955-

    2016-01-01

    OECD projektist "Education 2030", mille eesmärgiks on võtmekompetentside täpsustamine. Käsitlus hõlmab lisaks kognitiivsetele ka sotsiaalseid ja emotsionaalseid aspekte. Eesti võimalustest projekti panustada, projekti "Education 2030" tegevustest ja suundumustest

  7. Köök / Eve Arpo, Bibi Steinberg

    Index Scriptorium Estoniae

    Arpo, Eve

    2009-01-01

    Kaasaegsed köögid, köögitehnika. Nõuandeid köögi planeerimiseks. Peter Distoli disainitud suhkrust köök. Rahvusvahelisel disainivõistlusel Electro Design Lab 2008 eksponeeritud kodumasinad. Esikoha võitis Stefan Buchbergeri disainitud moodulitest koosnev külmik

  8. Memento soovib Kuressaarde rajada Kaastundeseina / Evely Aavik

    Index Scriptorium Estoniae

    Aavik, Evely

    2008-01-01

    Eesti Õigusvastaselt Represseeritute Liit Memento plaanib Kuressaare kesklinna rajada Kaastundeseina ning jäädvustada sellel valdade kaupa kõigi Saare maakonnast 1941. ja 1949. aastal Siberisse küüditatute nimed

  9. Tartu Jaani kiriku skulptuuride konserveerimisest / Eve Alttoa

    Index Scriptorium Estoniae

    Alttoa, Eve

    2006-01-01

    Terrakotaskulptuuridest, nende seisundist, terrakotaskulptuuride konserveerimise metoodika väljatöötamisest, Saksamaa abist, fassaadi- ja interjööriskulptuuridest. Fasaadiskulptuuride koopiad on valmistanud skulptuurirestauraatorid Isabel Aaso ja Alesh Zahradnik. Fassaadil on ka August Volzi aastail 1899-1904 tehtud koopiad. Bibliograafia lk. 16

  10. Robotics Team Lights Up New Year's Eve

    Science.gov (United States)

    LeBlanc, Cheryl

    2011-01-01

    A robotics team from Muncie, Indiana--the PhyXTGears--is made up of high school students from throughout Delaware County. The group formed as part of the FIRST Robotics program (For Inspiration and Recognition of Science and Technology), an international program founded by inventor Dean Kamen in which students work with professional engineers and…

  11. Ocular firework injuries at New Year's eve.

    Science.gov (United States)

    Sacu, Stefan; Ségur-Eltz, Nikolaus; Stenng, Karin; Zehetmayer, Martin

    2002-01-01

    To prospectively study mechanisms and injury characteristics of ocular firework burns. A prospective analysis of all patients with firework injuries attending the Department of Ophthalmology, University of Vienna, between 1994 and 2001. We looked for classes of fireworks and mechanisms of injuries. The number of diagnoses was established and their severity classified. During this period (8 years) we identified 116 eyes of 102 patients. 67/102 (66%) of all injuries were caused by class II and III fireworks. Patients ranged between 4 and 83 years. Ocular injuries occurred more frequently in males (69, 68%) and affected the right eye in 53 patients (52.5%). Ocular firework injuries to minors (under the age of 18 years) occurred in 48 (49%). The most common types of injury were skin and corneal erosions and abrasions (32/116, 28%). 11/116 eyes (10%) had severe injuries. 8 of 11 severe injuries (72%) occurred in minors (<18 years). 2 patients (1.7%) developed permanent blindness. In 32/116 patients (28%), the ocular trauma resulted in visual impairment, mainly due to corneal scars or retinal pathologies. In all patients, the severity index was 1.4 +/- 0.8. In minors the severity index was 1.6 +/- 1.0, in adults 1.2 +/- 0.5 (p = 0.013). Injuries in minors were significantly more severe than those in adults. Possible preventive measures include legislation, education of minors and eye protection. Copyright 2002 S. Karger AG, Basel

  12. Eesti ehted Firenzes

    Index Scriptorium Estoniae

    2005-01-01

    Galeriis Le Arti Orafe on avatud kuue nimeka Euroopa ehtekoolkonna näitus "Chroma". Eestist on töödega esindatud Andrus Rumm, Eve Margus-Villems, Julia-Maria Pihlak, Kertu Tuberg, Kristiina Laurits, Kärt Maran, Maarja Niinemägi, Merle Kasonen, Piret Hirv, Tanel Veenre

  13. Mis jääb kunstist lõpuks sõelale? / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2011-01-01

    15. Tallinna graafikatriennaalist "Armastuse, mitte raha pärast" Kumu Kunstimuuseumis. Triennaali kuraatorid: Simon Rees, Eve Kask, Eha Komissarov, kujundajad: Neeme Külm, Ralf Lõoke. Óskar Muñoze (Colombia), Ellie Daviesi (Suurbritannia), Andrew Raftery (USA), Kai Kuusingu ja Anu Kalmu töödest

  14. "Su mõte on see, mida elad" : vanadus / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2005-01-01

    Reet Varblase kuraatoriprojektist "Homo grandis natu" Tallinna Kunstihoones kuni 15. V. Tallinna Kunstikooli õpilaste (õpetaja Katrin Tukmann), Katarzyna Kozyra, Eveli Variku, Marge Monko, Piia Ruberi & Doris Kareva ja Mare Mikofi töödest, Tallinna Ülikooli audiovisuaalkunsti osakonnas tehtud filmidest (Elen Lotman, Jaak Kilmi, Kalev Hiller)

  15. Familial tendency and dietary association of goitre in Gamo-Gofa ...

    African Journals Online (AJOL)

    Objective: To assess the familial tendency and dietary association of goitre. Design: Ciaectional study with descripEve and analytical components. Setting: Goma-Gofa, south Ethiopia. Subjects: Five hundred and ninety seven elementary school children aged 6-18 years and their biological parents. Results: Prevalence of ...

  16. The European energy community is now

    International Nuclear Information System (INIS)

    Andoura, Sami; Buzek, Jerzy; Delors, Jacques; Vitorino, Antonio

    2013-01-01

    On the eve of the European Council on 22 May dealing with energy issues, the Jacques Delors Institute publishes a Tribune calling for the implementation of a positive agenda for the European energy policy and the definition of the concrete bases of a genuine European Energy

  17. African Journal of Chemical Education - Vol 7, No 2 (2017)

    African Journals Online (AJOL)

    Editorial: AJCE is about to publish a special issue on the eve of ACRICE 3 · EMAIL FREE ... Knowledge, attitudes and practices associated with pesticide use among ... (ICT) resources in classroom delivery by secondary school chemistry teachers ... Spectrophotometry mole ratio and continuous variation experiments with ...

  18. Beznau nuclear power plant: comments of the Federal Department of Transport, Communications and Energy on the reproaches of Greenpeace

    International Nuclear Information System (INIS)

    Ogi, A.

    1995-01-01

    Answer of the chairman of the EVED (Federal Department of Transport, Communications and Energy) to the open letter in which Greenpeace Switzerland made massive accusations against the nuclear power plant Beznau and the HSK (Federal Nuclear Safety Inspectorate). All the charges are rebutted in this answer

  19. Anxious politics in the European city: An introduction

    NARCIS (Netherlands)

    Modest, W.; Koning, A. de

    2016-01-01

    At the time of writing this introduction, the news media were still filled with concerns over the New Year's Eve incidents in Cologne. As reported, during those celebrations, close to Cologne's central station, men described as being of Middle Eastern or North African appearance, and as having

  20. Nüüd kunst, nüüd tulevik / Sandra Jõgeva

    Index Scriptorium Estoniae

    Jõgeva, Sandra, 1976-

    2008-01-01

    Vilniuse II rahvusvaheline graafikabiennal "Present Time. Now Art Now Future" Vilniuse Kaasaegse Kunsti Keskuses kuni 11. V. Kuraatorid Ignas Kazakevicius ja Jurate Rekeviciute. Eestist osalevad Peeter Allik, Eve Kask ja Sandra Jõgeva. Kuraator Jurate Rekeviciute biennaali alanäitusest "Valmis ajalooks" Gediminase avenüü kaubanduskeskuse galeriis

  1. Let’s focus on our Nursery school!

    CERN Multimedia

    Staff Association

    2016-01-01

    In the 241st issue of Echo, the Staff Association shared its concerns about the future of the CERN Nursery school. Indeed, the EVEE ‘Espace de vie Enfantine et École’ has faced significant financial difficulties in the last few years. According to an audit carried out in 2015, overall the management is sound, but the report shows that the potential gains are not sufficient to restore budgetary balance. Naturally, the EVEE is turning to CERN in order for the Organization to increase its commitment to ensure the sustainability of this structure which is crucial for the lives of many CERN families. To this end, a joint working group has been set up by Martin Steinacher, Director for Finance and Human Resources, who has given the mandate (see below) and established the composition of the group. This joint working group being technical in nature, it will also be necessary to hold political discussions between the Staff Association and the Management. An internal working group of t...

  2. The new Meyrin crèche takes its first steps

    CERN Multimedia

    2008-01-01

    The new Meyrin crèche was inaugurated on 10 October and already caters for 16 children of CERN personnel. Copyright: Laurent Barlier. Copyright: Robert Tillmann. At the end of August, the new Meyrin crèche in Champs-Fréchets, the Espace de Vie Enfantine (EVE), welcomed its first intake of infants. They included 16 children of members of the CERN personnel who are benefiting from the agreement signed in 2007 with the commune of Meyrin (see Bulletin n°43&44/2007). The crèche was officially inaugurated on 10 October with several CERN representatives in attendance, including HR Department Head, Enrico Chiaveri, and Head of the Relations with the Host States Service, Friedmann Eder. The following day, EVE held an open day for the inhabitants of Meyrin and interested members of the CERN personnel. The new 1516 m2 building ‘s spaces have very clean and ...

  3. Official holidays in 2015 and end-of-year closure 2015/2016

    CERN Multimedia

    2014-01-01

    Official holidays in 2015 and end-of-year closure 2015/2016 (Application of Articles R II 4.38 and R II 4.39 of the Staff Regulations).   Official holidays in 2015 (in addition to the special leave during the annual closure): Thursday, 1 January (New Year) Friday, 3 April (Good Friday) Monday, 6 April (Easter Monday) Friday, 1 May Thursday, 14 May (Ascension day) Monday, 25 May (Whit Monday) Thursday, 10 September ("Jeûne genevois") Thursday, 24 December (Christmas Eve) Friday, 25 December (Christmas) Thursday, 31 December (New Year’s Eve) Annual closure of the site of the Organization during the Christmas holidays and special leave granted by the Director-General: The Laboratory will be closed from Saturday, 19 December 2015 to Sunday, 3 January 2016 inclusive (without deduction of annual leave). The first working day in the New Year will be Monday, 4 January 2016. Human Resources Department Tel. 73903/79257

  4. Quantum dialogue without information leakage based on the entanglement swapping between any two Bell states and the shared secret Bell state

    International Nuclear Information System (INIS)

    Ye, Tian-Yu; Jiang, Li-Zhen

    2014-01-01

    In order to avoid the risk of information leakage during the information mutual transmission between two authorized participants, i.e. Alice and Bob, a quantum dialogue protocol based on the entanglement swapping between any two Bell states and the shared secret Bell state is proposed. The proposed protocol integrates the ideas of block transmission, two-step transmission and unitary operation encoding together using the Bell states as the information carriers. Besides the entanglement swapping between any two Bell states, a shared secret Bell state is also used to overcome the information leakage problem, which not only makes Bob aware of the prepared initial state but also is used for Bob's encoding and entanglement swapping. Security analysis shows that the proposed protocol can resist the general active attacks from an outside eavesdropper Eve. Moreover, the relation between the maximal amount of information Eve can gain and the detection probability is derived. (paper)

  5. Paradise Lost Dressed in the Costume of History: John Martin’s Rendition of Paradise Lost

    Directory of Open Access Journals (Sweden)

    Laleh Atashi

    2011-01-01

    Full Text Available The story of the loss of paradise has been read and interpreted in different ages. Commentary on Milton's Paradise Lost is not limited to verbal texts; painters and illustrators have contributed greatly to the poem by presenting their own time-bound readings and interpretations of the poem through their illustrations that are far beyond mere decorations. John Martin, in the aftermath of the Industrial Revolution, deletes the Father and the Son from his illustrations. Only angels such as Raphael are the representations of deity and are as powerless and tiny as Adam and Eve. Adam and Eve, after the Fall seem as small, powerless and as subjugated to the natural surrounding as they were before the Fall. Satan is the only powerful figure in his elegant palace. Through a new historical outlook, the researchers aim at exposing the workings of ideology and dominant discourses that informed John Martin's pictorial reading of Milton's poem in the early 19th century

  6. The Feminization of Female Figures in Spanish Women's Poetry of the 1980s

    Directory of Open Access Journals (Sweden)

    Sharon Keefe Ugalde

    1992-01-01

    Full Text Available The paper examines how women poets appropriate and transform man-made biblical and literary figures—Eve, Lot's wife, and Ophelia—in order to express female meaning. Poetry by women published since the democratization of Spain in the late 1970s serves as the basis of the study. Three strategies of feminization stand out. Enhancement reflects the predicament of poets living roles imposed by male denomination, but sensing the presence of a silenced, imprisoned self. Subversion is aimed at dismantling patriarchally defined reality, and revision corresponds to the constructive task of self-discovery. Poets, for example, embrace Ophelia, recognizing that their desperation (like hers is rooted in patriarchal order, and subvert the image of Lot's wife into a demand for autonomy. Eve is revised to communicate the awareness that female subjectivity is closely bound to female eroticism, and perhaps most astonishingly, poor, helpless Ophelia comes to symbolize woman's new freedom and power to inscribe herself.

  7. Event Displays for the Visualization of CMS Events

    CERN Document Server

    Jones, Christopher Duncan

    2010-01-01

    During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

  8. Event Display for the Visualization of CMS Events

    Science.gov (United States)

    Bauerdick, L. A. T.; Eulisse, G.; Jones, C. D.; Kovalskyi, D.; McCauley, T.; Mrak Tadel, A.; Muelmenstaedt, J.; Osborne, I.; Tadel, M.; Tu, Y.; Yagil, A.

    2011-12-01

    During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

  9. IT Services Availability during the Annual CERN Closure 2006

    CERN Document Server

    2006-01-01

    Most of the physics, technical, administrative and communications services provided by the IT Department, including LCG (EGEE) production services, will remain available during the CERN annual closure (although EDH requests will stay queued). No interruptions are scheduled (beyond PABX maintenance work on 3-5 January 2007) but restoration of services in case of failure cannot be guaranteed. Problems which arise should be addressed within about half a day except around Christmas Eve and Christmas Day (24 and 25 December) and New Year's Eve and New Year's Day (31 December and 1 January). Incidents will be documented at http://cern.ch/ssb. Although the backup service will be operational, backups cannot be guaranteed and file restores will not be possible. Damaged tapes in Castor will not be processed. Please note that the Helpdesk will be closed but an operator service will be maintained throughout and can be reached at extension 75011 or by email to computer.operations@cern.ch where urgent problems may be ad...

  10. IT Services Availability during the 2007 Annual CERN Closure

    CERN Multimedia

    IT Department

    2007-01-01

    Most of the physics, technical, administrative and communications services provided by the IT Department - including LCG (EGEE) production services - will remain available during the CERN annual closure (although EDH requests will stay queued). No interruptions are scheduled but in the event of failure, the restoration of services cannot be guaranteed. Problems will be dealt with on a best effort basis only. However, for the following services: Network, Databases, Mail, Web, Windows & Terminal Services, Indico, CDS, Grid (SAM, FTS, VOMS, GridView, Resource Brokers): experts should be reachable to start investigations within about half a day except around Christmas Eve and Christmas Day (24 and 25 December) and New Year’s Eve and New Year’s Day (31 December and 1 January). Incidents will be documented at http://cern.ch/ssb; The backup service: will remain operational, but backups cannot be guaranteed and file restores will not be possible; Castor: damaged tapes wi...

  11. Availability of IT services during the 2009 CERN annual closure

    CERN Multimedia

    IT Department

    2009-01-01

    Most of the services provided by the IT Department - including WLCG (EGEE) production services - will remain available during the CERN annual closure. No interruptions are scheduled but in the event of a failure, the restoration of services cannot be guaranteed. Problems will be dealt with on a best effort basis only. However, for the following services: Network, Databases, Mail, Web, Windows & Terminal Services, Authentication Services, Indico, CDS, Grid (SAM, FTS, VOMS, GridView): experts should be reachable to start investigations within about half a day except on Christmas Eve and Christmas Day (24 and 25 December) and New Year’s Eve and New Year’s Day (31 December and 1 January). Incidents will be documented at http://cern.ch/ssb. The backup service will remain operational, but backups cannot be guaranteed and file restores may not be possible. Castor: damaged tapes will not be processed. Please note that the Helpdesk will be closed but an operator service will ...

  12. IT Services Availability during the CERN Annual Closure 2010

    CERN Multimedia

    2010-01-01

    Most of the services provided by the IT Department - including WLCG production services - will remain available during the CERN annual closure. No interruptions are scheduled but in case of failure, the restoration of services cannot be guaranteed. Problems will be dealt with on a best effort basis only. However, please note:   •\tExperts should be reachable to start investigations on the following services within about half a day except around Christmas Eve and Christmas Day (24 and 25 December) and New Year's Eve and New Year's Day (31 December and 1 January) -- Network, Databases, Linux, Mail, Printing, Telecom, Web, Windows & Windows Terminal Services, Account Management, Castor, Indico, Inspire, Invenio, Grid (SAM, Gridview, Nagios, messaging), and the room booking system, Incidents will be documented at http://cern.ch/ssb. •\tThe backup service will remain operational, but backups cannot be guaranteed and file restores may not be possible. •\tFor the Castor serv...

  13. Official holidays in 2012 and end-of-year closure 2012/2013

    CERN Multimedia

    2012-01-01

    (Application of Articles R II 4.38 and R II 4.39 of the Staff Regulations) Official holidays in 2012 (in addition to the special leave during the annual closure): Sunday, 1st January (New Year); Friday, 6th April (Good Friday); Monday, 9th April (Easter Monday); Tuesday, 1st May; Thursday, 17th May (Ascension day); Monday, 28th May (Whit Monday); Thursday, 6th September ("Jeûne genevois"); Monday, 24th December (Christmas Eve); Tuesday, 25th December (Christmas); Monday, 31st December (New Year’s Eve). Annual closure of the site of the Organization during the Christmas holidays and day of special leave granted by the Director-General : The Laboratory will be closed from Saturday, 22nd December 2012 to Sunday, 6th January 2013 inclusive (without deduction of annual leave). The first working day in the New Year will be Monday, 7th January 2013. Human Resources Department Tel. 73903

  14. Event Display for the Visualization of CMS Events

    International Nuclear Information System (INIS)

    Bauerdick, L A T; Eulisse, G; Jones, C D; McCauley, T; Osborne, I; Kovalskyi, D; Tadel, A Mrak; Muelmenstaedt, J; Tadel, M; Tu, Y; Yagil, A

    2011-01-01

    During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

  15. IT Services availability during CERN annual closure Dec 2004-Jan2005

    CERN Multimedia

    2004-01-01

    Mail, CERN Windows (NICE), Web services, LXPLUS, LXBATCH, AFS, Automated tape devices, Castor, Backups, software license servers, Sundev, CVS and Print Servers, CDS Search, Submit and Agenda, InDiCo, EDMS (in collaboration with TS Department), CMS disc servers, the AB NFS servers (SLNFS1, PSNFS1 and MTBNFS1, that PS group runs for AB Department), Campus Network, Remedy, and Security services will be available during the CERN annual closure. The physics database cluster, replication location service as well as accdb, cerndb and admsdb are the only databases available; CCDB will be closed for public access. Problems developing on scheduled services should be addressed within about half a day except around Christmas Eve and Christmas Day (24 and 25 December) and New Year's Eve and New Year's Day (31 December and 1st January). For Administrative Computing Services, ERT (Electronic Recruitment Tool) will be the only service operational; all other AIS applications such as EDH, CET, HRT etc. will be unavailable. Al...

  16. IT Services availability during CERN annual closure

    CERN Multimedia

    2003-01-01

    Mail, Cern Windows (NICE ),  Web services,  LXPLUS, LXBATCH, Automated tape devices, Castor, Backups, software license servers, Sundev, CVS and Print Servers, CDS and Agenda-Maker, EDMS (in collaboration with EST Division), CMS disc servers, Campus Network,  Remedy, Security and VPN services will be available during the CERN annual closure. The physics database cluster, replication location service as well as accdb, cerndb and admsdb are the only databases available, CCDB will be closed for public access. Problems developing on scheduled services should be addressed within about half a day except around  Christmas Eve and Christmas Day ( 24 and 25th December ) and New Year's Eve and New Years Day (31st December and 1st Janauary. All other services will be left running mostly unattended. No interruptions are scheduled but restoration of the service in case of failure cannot be guaranteed. Please note that the Helpdesk will be closed, that no file restores from backups will be possible and damaged tapes wi...

  17. A Looping-Based Model for Quenching Repression.

    Directory of Open Access Journals (Sweden)

    Yaroslav Pollak

    2017-01-01

    Full Text Available We model the regulatory role of proteins bound to looped DNA using a simulation in which dsDNA is represented as a self-avoiding chain, and proteins as spherical protrusions. We simulate long self-avoiding chains using a sequential importance sampling Monte-Carlo algorithm, and compute the probabilities for chain looping with and without a protrusion. We find that a protrusion near one of the chain's termini reduces the probability of looping, even for chains much longer than the protrusion-chain-terminus distance. This effect increases with protrusion size, and decreases with protrusion-terminus distance. The reduced probability of looping can be explained via an eclipse-like model, which provides a novel inhibitory mechanism. We test the eclipse model on two possible transcription-factor occupancy states of the D. melanogaster eve 3/7 enhancer, and show that it provides a possible explanation for the experimentally-observed eve stripe 3 and 7 expression patterns.

  18. On the origins of OR and its institutions

    DEFF Research Database (Denmark)

    Fores, Sarah; Krarup, Jakob

    2013-01-01

    Operational Research (OR) is the science of decision-making. From its military origins on the eve of World War II, OR has over the past seven decades matured to become a discipline that is recognised worldwide for its contributions to managerial planning and complex operations on all levels within...

  19. Missugustes virtuaalsetes võrgustikes sina kaasa lööd? / Johanna Helin, Mart Laanpere, Uno Traat ... [jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad maailmahariduse projekti "Vaata ja muuda!" juht Johanna Helin, TLÜ haridustehnoloogia keskuse juhataja Mart Laanpere, Sisekaitse Akadeemia kriminoloogia õppejõud Uno Traat, TLÜ Haapsalu kolledži direktor Eve Eisenschmidt, Kose Gümnaasiumi saksa keele õpetaja Astrid Sildnik, TÜ füüsika instituudi dotsent Toomas Plank

  20. South African academia in crisis: The spread of `contrived collegial ...

    African Journals Online (AJOL)

    In 1999, on the eve of rationalisation of South African higher education, J. M. Coetzee published a book entitled Disgrace. In this publication he narrates the tale of a Classics and Modern Languages professor transformed into an adjunct professor of communications, a marketable identity, as a consequence of ...

  1. Raud kureerib kunstnikke

    Index Scriptorium Estoniae

    2001-01-01

    21. dets.-12. jaan. on on Haus galeriis Rein Raua kuraatoriprojekt "KevadSuviSügisTalv. Murdumispunkt". Näitusel osalevad Eve Kask, Peeter Laurits, Dainius Lishkevicius (Leedu), Rekha Menon (India/USA), Mall Nukke, Herkki Merila, Jorma Puranen (Soome), Rosita Raud, Ene-Liis Semper, Liina Siib, S&P Stanikas (Leedu)

  2. Security proof for round robin differential phase shift QKD

    NARCIS (Netherlands)

    Leermakers, D.; Skoric, B.

    2017-01-01

    We give the first information-theoretic security proof of the `Round Robin Differential Phase Shift' Quantum Key Distribution scheme. Our proof consists of the following steps. We construct an EPR variant of the scheme. We identify Eve's optimal way of coupling an ancilla to an EPR qudit pair under

  3. Unravelling hieroglyphs : urban traffic signs and the league of nations

    NARCIS (Netherlands)

    Schipper, F.

    2009-01-01

    This article discusses road traffic signs in the Interwar years. The article first sketches the often difficult relationship between the car and the city and society at large. It proposes road signs were introduced in part to mitigate this antagonistic relation. On the eve of the First World War

  4. The New Spirit of Capitalism in European Liberal Arts Programs

    Science.gov (United States)

    Claus, Jakob; Meckel, Thomas; Pätz, Farina

    2018-01-01

    The following paper suggests a connection between recent developments in the justification of the capitalist system and contemporary European Liberal Arts programs. By looking at Luc Boltanski's and Eve Chiapello's study on "The New Spirit Of Capitalism" and Gilles Deleuze's term of "societies of control" we highlight a pivot…

  5. Mida sa arvad üliõpilaste õppetoetuse süsteemist? / Kadri Inselberg

    Index Scriptorium Estoniae

    Inselberg, Kadri

    2008-01-01

    Küsimusele vastavad Tartu Ülikooli riigiõiguse üliõpilane Eveli Õigus, Eesti Maaülikooli veemajanduse üliõpilane Tauri Tamar, Tartu Ülikooli õigusteaduskonna üliõpilane Olavi Malla ja Tallinna Tehnikaülikooli Tartu Kolledži üliõpilane Katre Kasemägi

  6. Comment on 'Quantum secret sharing based on reusable Greenberger-Horne-Zeilinger states as secure carriers'

    International Nuclear Information System (INIS)

    Gao Fei; Guo Fenzhuo; Wen Qiaoyan; Zhu Fuchen

    2005-01-01

    In a recent paper [S. Bagherinezhad and V. Karimipour, Phys. Rev. A 67, 044302 (2003)], a quantum secret sharing protocol based on reusable Greenberger-Horne-Zeilinger states was proposed. However, in this Comment, it is shown that this protocol is insecure if Eve employs a special strategy to attack

  7. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

    Directory of Open Access Journals (Sweden)

    Daniela Schmid

    2014-09-01

    Full Text Available In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0 and the low-affinity neurotrophin receptor p75NTR . This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination.

  8. IκB kinase β regulates epithelium migration during corneal wound healing.

    Directory of Open Access Journals (Sweden)

    Liang Chen

    2011-01-01

    Full Text Available The IKKβ is known to regulate transcription factor NF-κB activation leading to inflammatory responses. Recent gene knockout studies have shown that IKKβ can orchestrate local inflammatory responses and regulate homeostasis of epithelial tissues. To investigate whether IKKβ has an intrinsic role in epithelial cells, we established an in vivo system in the immune privileged corneal epithelium. We generated triple transgenic Krt12(rtTA/rtTAt/tet-O-Cre/Ikkβ(F/F (Ikkβ(ΔCE/ΔCE mice by crossing the Krt12-rtTA knock-in mice, which express the reverse tetracycline transcription activator in corneal epithelial cells, with the tet-O-Cre and Ikkβ(F/F mice. Doxycycline-induced IKKβ ablation occurred in corneal epithelial cells of triple transgenic Ikkβ(ΔCE/ΔCE mice, but loss of IKKβ did not cause ocular abnormalities in fetal development and postnatal maintenance. Instead, loss of IKKβ significantly delayed healing of corneal epithelial debridement without affecting cell proliferation, apoptosis or macrophage infiltration. In vitro studies with human corneal epithelial cells (HCEpi also showed that IKKβ was required for cytokine-induced cell migration and wound closure but was dispensable for cell proliferation. In both in vivo and in vitro settings, IKKβ was required for optimal activation of NF-κB and p38 signaling in corneal epithelial cells, and p38 activation is likely mediated through formation of an IKKβ-p38 protein complex. Thus, our studies in corneal epithelium reveal a previously un-recognized role for IKKβ in the control of epithelial cell motility and wound healing.

  9. In utero and lactational exposure to vinclozolin and genistein induces genomic changes in the rat mammary gland.

    Science.gov (United States)

    El Sheikh Saad, H; Toullec, A; Vacher, S; Pocard, M; Bieche, I; Perrot-Applanat, M

    2013-02-01

    Exposure to low doses of environmental estrogens such as bisphenol A and genistein (G) alters mammary gland development. The effects of environmental anti-androgens, such as the fungicide vinclozolin (V), on mammary gland morphogenesis are unknown. We previously reported that perinatal exposure to G, V, and the GV combination causes histological changes in the mammary gland during the peripubertal period, suggesting alterations to the peripubertal hormone response. We now investigate whether perinatal exposure to these compounds alters the gene expression profiles of the developing glands to identify the dysregulated signaling pathways and the underlying mechanisms. G, V, or GV (1 mg/kg body weight per day) was added to diet of Wistar rats, from conception to weaning; female offspring mammary glands were collected at postnatal days (PNDs) 35 and 50. Genes displaying differential expression and belonging to different functional categories were validated by quantitative PCR and immunocytochemistry. At PND35, G had little effect; the slight changes noted were in genes related to morphogenesis. The changes following exposure to V concerned the functional categories associated with development (Cldn1, Krt17, and Sprr1a), carbohydrate metabolism, and steroidogenesis. The GV mixture upregulated genes (Krt17, Pvalb, and Tnni2) involved in muscle development, indicating effects on myoepithelial cells during mammary gland morphogenesis. Importantly, at PND50, cycling females exposed to GV showed an increase in the expression of genes (Csn2, Wap, and Elf5) related to differentiation, consistent with the previously reported abnormal lobuloalveolar development previously described. Thus, perinatal exposure to GV alters the mammary gland hormone response differently at PND35 (puberty) and in animals with established cycles.

  10. Development of Highly Sensitive and Specific mRNA Multiplex System (XCYR1) for Forensic Human Body Fluids and Tissues Identification

    Science.gov (United States)

    Xu, Yan; Xie, Jianhui; Cao, Yu; Zhou, Huaigu; Ping, Yuan; Chen, Liankang; Gu, Lihua; Hu, Wei; Bi, Gang; Ge, Jianye; Chen, Xin; Zhao, Ziqin

    2014-01-01

    The identification of human body fluids or tissues through mRNA-based profiling is very useful for forensic investigations. Previous studies have shown mRNA biomarkers are effective to identify the origin of biological samples. In this study, we selected 16 tissue specific biomarkers to evaluate their specificities and sensitivities for human body fluids and tissues identification, including porphobilinogen deaminase (PBGD), hemoglobin beta (HBB) and Glycophorin A (GLY) for circulatory blood, protamine 2 (PRM2) and transglutaminase 4 (TGM4) for semen, mucin 4 (MUC4) and human beta defensin 1(HBD1) for vaginal secretion, matrix metalloproteinases 7 and 11 (MMP7 and MMP11) for menstrual blood, keratin 4(KRT4) for oral mucosa, loricrin (LOR) and cystatin 6 (CST6) for skin, histatin 3(HTN3) for saliva, statherin (STATH) for nasal secretion, dermcidin (DCD) for sweat and uromodulin (UMOD) for urine. The above mentioned ten common forensic body fluids or tissues were used in the evaluation. Based on the evaluation, a reverse transcription (RT) PCR multiplex assay, XCYR1, which includes 12 biomarkers (i.e., HBB, GLY, HTN3, PRM2, KRT4, MMP11, MUC4, DCD, UMOD, MMP7, TGM4, and STATH) and 2 housekeeping genes [i.e., glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and 18SrRNA], was developed. This assay was further validated with real casework samples and mock samples (with both single source and mixture) and it was approved that XCYR1 is effective to identify common body fluids or tissues (i.e., circulatory blood, saliva, semen, vaginal secretion, menstrual blood, oral mucosa, nasal secretion, sweat and urine) in forensic casework samples. PMID:24991806

  11. Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse

    International Nuclear Information System (INIS)

    Lallemant, Benjamin; Hollande, Frédéric; Lallemant, Jean-Gabriel; Lumbroso, Serge; Brouillet, Jean-Paul; Evrard, Alexandre; Combescure, Christophe; Chapuis, Heliette; Chambon, Guillaume; Raynal, Caroline; Reynaud, Christophe; Sabra, Omar; Joubert, Dominique

    2009-01-01

    Analysis of 23 published transcriptome studies allowed us to identify nine genes displaying frequent alterations in HNSCC (FN1, MMP1, PLAU, SPARC, IL1RN, KRT4, KRT13, MAL, and TGM3). We aimed to independently confirm these dysregulations and to identify potential relationships with clinical data for diagnostic, staging and prognostic purposes either at the tissue level or in saliva rinse. For a period of two years, we systematically collected tumor tissue, normal matched mucosa and saliva of patients diagnosed with primary untreated HNSCC. Expression levels of the nine genes of interest were measured by RT-qPCR in tumor and healthy matched mucosa from 46 patients. MMP1 expression level was measured by RT-qPCR in the salivary rinse of 51 HNSCC patients and 18 control cases. Dysregulation of the nine genes was confirmed by the Wilcoxon test. IL1RN, MAL and MMP1 were the most efficient diagnostic markers of HNSCC, with ROC AUC > 0.95 and both sensitivity and specificity above 91%. No clinically relevant correlation was found between gene expression level in tumor and T stage, N stage, tumor grade, global survival or disease-free survival. Our preliminary results suggests that with 100% specificity, MMP1 detection in saliva rinse is potentially useful for non invasive diagnosis of HNSCC of the oral cavity or oropharynx, but technical improvement is needed since sensitivity was only 20%. IL1RN, MAL and MMP1 are prospective tumor diagnostic markers for HNSCC. MMP1 overexpression is the most promising marker, and its detection could help identify tumor cells in tissue or saliva

  12. The health and economic impact of fireworks-related injuries in Iran: a household survey following the New Year's Festival in Tehran.

    Science.gov (United States)

    Saadat, Soheil; Naseripour, Masood; Smith, Gary A

    2010-07-01

    Fireworks are used worldwide as a part of national and cultural celebrations. Personal use of fireworks is associated with serious injuries. The "Last Wednesday Eve Festival" is celebrated on the evening before the last wednesday of the Persian calendar year. In recent years, fireworks have been widely used during the festival, which has resulted in injuries. The aim of this study was to determine the incidence and risk factors of fireworks-related injuries associated with the Last Wednesday Eve Festival, in Tehran, Iran. A household survey of residents of greater Tehran, using a random cluster sampling design was performed. Number of fireworks-related injuries, expenditures for fireworks and medical treatment of fireworks-related injuries, length of hospital stay for treatment of these injuries and the personal property damage was gathered. Interviews were conducted of 2475 households in greater Tehran. At least one member of 19.8% of these households had used fireworks during the 2007 Last Wednesday Eve Festival. Fireworks-related injuries were more common among households whose members had used homemade fireworks than among households whose members had used only commercially made fireworks (OR=16.5, 95% CI: 5.7-47.5). Forty-five households reported that they had sustained personal property damage caused by fireworks during the festival, costing a mean of US$ 36.60. Households with at least one injured member spent a mean of US$ 441.90 for medical care and a mean of US$ 70.80 for other expenses related to seeking medical care. The overall incidence of fireworks-related injury among household members was 0.2% (95% CI: 0.1-0.3%). Fireworks-related injury incidence was highest in the 10-19 age group. The total estimated number of fireworks-related injuries in Tehran during the 2007 Last Wednesday Eve Festival was approximately 17,000. Among the 20 injured individuals, 4 persons (20.0%) were hospitalised for a mean of 2.8 days. The personal use of fireworks in Iran

  13. Area Handbook Series: Japan: A Country Study

    Science.gov (United States)

    1992-01-01

    special decorations, eating noodles on New Year’s Eve to show continuity into the new year, and playing a poetry card game are among the more...transmitted by satellite for instant replay after the government, in 1979, set up the Communications and Broadcasting Satellite Or- ganization. Japan’s first

  14. Psychotropic medication use among adolescent disaster survivors: a prospective cohort study.

    NARCIS (Netherlands)

    Dorn, T.; Yzermans, C.J.; Kerssens, J.J.; Veen, P.M.H. ten

    2004-01-01

    Background: We study the health consequences of a fire disaster which took place on January 1st, 2001, in Volendam, the Netherlands. The fire occurred in a discotheque where about 300 youngsters were celebrating new year’ eve. 14 youngsters were killed and about 200 injured. Next to the threat,to

  15. Agro 2012 June

    African Journals Online (AJOL)

    Waichman, A.V., E., Eve and N.C.D.S., Nina (2007). Do Farmers Understand the. Information Displayed on Pesticide Product Labels? A Key Question to Reducing. Pesticide Exposure and Risk of Poisoning in Brazilian Amazon. 576-583. Ibitayo, O. O., (2007).Egyptian Farmers in Nigeria, Lesson for Extension Work. Institute.

  16. Kolmikportree eesti kunstist ehk kolm uut kunstifilmi / Riin Kübarsepp

    Index Scriptorium Estoniae

    Kübarsepp, Riin, 1978-

    2005-01-01

    Tallinna Kinomajas esilinastusid 28. okt. kolm uut dokumentaalfilmi eesti kunstnikest, mis valminud Eesti Kunstnike Liidu tellimusel : "F.F.F.F. läheb laiali" (Kuukulgur Film 2005, rezh. Marko Raat), "Mare Vint" (Exitfilm 2005, rezh. Anri Rulkov) ja "Jaan Klõsheiko" (Estonia Film 2005, rezh.-d Eve Ester, Igor Ruus)

  17. ÕhuLoss - ehtides maailma / Pekka Erelt

    Index Scriptorium Estoniae

    Erelt, Pekka, 1965-

    2011-01-01

    Ehtekunstnike rühmitusest õhuLoss (Kadri Mälk, Piret Hirv, Eve Margus-Villems, Tanel Veenre, Kristiina Laurits, Villu Plink, Katrin Sipelgas). Esimest korda astus rühmitus üles 10 aastat tagasi Hollandis Marzee galeriis toimunud näitusel. 2011. aasta augustis-septembris toimus näitus Tallinna Põhjatuletornis

  18. Biomass as feedstock for the industry : road to perdition or the promised land?

    NARCIS (Netherlands)

    Ad de Kok

    2013-01-01

    Are we at the eve of a transformation in our economic system? “Yes”, according to several visionary scientists and policymakers. They predict the rise of an economy that is based on biological materials, the so-called bio-based economy. The key challenge is that due to several socio-economic

  19. Inglise mood ja foto Kunstihoones

    Index Scriptorium Estoniae

    1999-01-01

    5. nov.-st Tallinna Kunstihoones näitus "Look at me", Suurbritannia mood ja fotograafia 1960ndatest tänapäevani. Kuraatorid Val Willams, Brett Rogers. Osalejaid. 6. XI samas eesti moekunstnike britiaineline moeshow. Osalevad Anu Lensment, Eve Hanson, Marit Ahven, Jaanus Vahtra, Marju Tammik, Anu Samarüütel

  20. Õhuloss ehk tuletorni juurde / Tiina Käesel ; kommenteerinud Tamara Luuk

    Index Scriptorium Estoniae

    Käesel, Tiina, 1943-

    2011-01-01

    Ehtekunstinäitus "Õhuloss" Tallinna Põhjatuletornis 25. septembrini 2011. Näitusega kaasneb raamat "Castle in the Air - Jewellery from Estonia - Õhuloss", koostajad Kadri Mälk ja Tanel Veenre. Rühmitusse "õhuLoss" kuuluvad Kadri Mälk, Piret Hirv, Eve Margus-Villems, Kristiina Laurits, Villu Plink, Tanel Veenre, Katrin Sipelgas

  1. 78 FR 68002 - Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD

    Science.gov (United States)

    2013-11-13

    ... 1625-AA00 Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during a fireworks display launched from a barge located in Baltimore... rule involves a fireworks display associated with a New Year's Eve event that will take place in...

  2. Kultuuridessant Sillamäe aatomilinna ehk Nemad ja meie / Ilja Sundelevitsh

    Index Scriptorium Estoniae

    Sundelevitsh, Ilja

    2006-01-01

    Eleonore de Montesquiou näitust "Aatomilinnad. Paldiski - Sillamäe" tutvustati 8. IX Sillamäe muuseumis, 24. VIII esitleti kunstniku projekti Paldiski muuseumis. Sillamäel käisid E. de Montesquiou, Anne Durez, Reet Varblane, Liina Siib, Eve Kiiler, Jaanika Peerna, Liis Jürgens, Tarmu Tamverk ja Ilja Sundelevitsh

  3. Uued ja vanad ruumimängud / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1998-01-01

    Inglise-eesti ühisnäitus 'Private views : taas/avastatud ruum Eesti ja Briti kaasaegses kunstis' Rotermanni soolalaos. Kuraatorid Mare Tralla, Pam Skelton. Feminismist kui tähenduslikust ruumist. Eve Kiileri, Mari Koorti, Liina Siibi, Susan Brindi, Ene-Liis Semperi, Anu Juuraku, Naomi Dinesi, rühmituse F.F.F.F., kuraatorite esinemisest.

  4. 12 Layout PPP adjusted.pmd

    African Journals Online (AJOL)

    Nubidga

    EDITORIAL. Reflections on Professionalization of Education in Cameroon. In his message to the youth on the eve of the 2015. 11th February Youth Day celebrations the Head of State, President Paul Biya, once more called for the professionalization of education in. Cameroon .This call comes eight years after the launching ...

  5. Osennaja moda : tshornõm-tshorno

    Index Scriptorium Estoniae

    2008-01-01

    Baltika kaubamärkide Monton, Ivo Nikkolo, Baltman ja Mosaic moekollektsioonidest sügiseks 2008. Tutvustavad Montoni naisterõivatse disainer Jaanika Sootna ning meesterõivaste disainer Jaana Varkki, Ivo Nikkolo disainer Eve Hanson, Baltmani disainer Erkki Engso ja Mosaici naisterõivaste disainer Evelin Lill ning meesterõivaste disainer Merle Lõhmus. Värvifotod

  6. A consensus process on management of major burns accidents: lessons learned from the café fire in Volendam, The Netherlands

    NARCIS (Netherlands)

    Welling, L.; Boers, M.; Mackie, D. P.; Patka, P.; Bierens, J. J. L. M.; Luitse, J. S. K.; Kreis, R. W.

    2006-01-01

    PURPOSE: The optimum response to the different stages of a major burns incident is still not established. The fire in a café in Volendam on New Year's Eve 2000 was the worst incident in recent Dutch history and resulted in mass burn casualties. The fire has been the subject of several investigations

  7. In Search of a Role to Play: The EU and the War in Syria

    NARCIS (Netherlands)

    Blockmans, S.

    2017-01-01

    Driven by the recognition that more needs to be done, the Council of Ministers adopted a new EU Strategy for Syria on the eve of the April 2017 Brussels donor. This Overview explores the potential of, and limits to, the different roles of the EU in the pursuit of its own (constitutional) objectives

  8. Constraining the Samurai: Rebellion and Taxation in Early Modern Japan

    NARCIS (Netherlands)

    Steele, A.; Paik, C.; Tanaka, S.

    On the eve of the Meiji Restoration in 1868, the nearly 300 semi-autonomous domains across Japan had widely varying tax rates. Some handed over 70 percent of their rice yield to the samurai ruler of the domain, while others provided 15 percent. This variation existed in spite of the similar fiscal

  9. Eesti kunstimaailm... / Ivika Kivi ; interv. R[eet] V[arblane

    Index Scriptorium Estoniae

    Kivi, Ivika

    2007-01-01

    Uus kuraator Ivika Kivi Grazi meediakunsti laborist, kus 3. IV avati Mare Tralla näitus "Her. Space", kuraatori võimalustest ja labori tulevikuplaanidest. Kavas on Piret Räni näitus "Hello Friend, Are You Impotent" (avamisel naiskunstnike seltsi Puhas Rõõm performance) ja Eve Kiileri näitus "Everyman Time Machine"

  10. The WTO and the Millennium Round: What Is at Stake for Public Education? Common Concerns for Workers in Education and the Public Sector.

    Science.gov (United States)

    Education International, Brussels (Belgium).

    On the eve of the year 2000, global public spending on education tops one trillion dollars. Against the backdrop of globalization, public education is currently being subjected to attacks by proponents of privatization and deregulation. The process is already underway, as is apparent from an important agreement reached by the World Trade…

  11. Traditional Festivals to Become Legal Holidays

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ As nearly everyone knows already,the state is going to rearrange the schedule of legal holidays. The four traditional Chinese festivals, inluding Mid-Autumn Day, Dragon Boat Festival,Tomb-Sweeping Day and Spring Festival Eve, will be made into legal holidays. As for the Golden Week system, should it be continued or canceled?

  12. Eesti graafika Rio de Janeiros / Jüri Kass

    Index Scriptorium Estoniae

    Kass, Jüri

    1999-01-01

    15. sept.-st Krakovi graafikatriennaali valiknäitusel Rio de Janeiro kaasaegse kunsti muuseumis esinevad Eestist Peeter Allik, Inga Heamägi, Eve Kask, Avo Keerend, Malle Leis, Ülle Marks, Raul Meel. 1997. a. Krakovi triennaalil ning sellele järgnenud sateliit- ja jätkunäitustel Eestist osalenud kunstnike loetelu.

  13. Big and small women facing small culture / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1999-01-01

    Feministlik kunst Eestis alates 1994. aastast. Näitustest EST. FEM, Kood-eks, Private Views. Videod. Fotoinstallatsioonid. Tuntumad kunstnikud: Mare Tralla, Ene-Liis Semper, Mari Laanemets, Eve Kiiler, Tiina Tammetalu, Kai Kaljo, Ly Lestberg, Liina Siib jt. Kunstnike rühmitused: F.F.F.F. Teemad: ema, väike naine, keha. 6 illustratsiooni

  14. Rapid method for identification of transgenic fish zygosity

    Directory of Open Access Journals (Sweden)

    . Alimuddin

    2007-07-01

    Full Text Available Identification of zygosity in transgenik fish is normally achieved by PCR analysis with genomic DNA template extracted from the tissue of progenies which are derived by mating the transgenic fish and wild-type counterpart.  This method needs relatively large amounts of fish material and is time- and labor-intensive. New approaches addressing this problem could be of great help for fish biotechnologists.  In this experiment, we applied a quantitative real-time PCR (qr-PCR method to analyze zygosity in a stable line of transgenic zebrafish (Danio rerio carrying masu salmon, Oncorhynchus masou D6-desaturase-like gene. The qr-PCR was performed using iQ SYBR Green Supermix in the iCycler iQ Real-time PCR Detection System (Bio-Rad Laboratories, USA.  Data were analyzed using the comparative cycle threshold method.  The results demonstrated a clear-cut identification of all transgenic fish (n=20 classified as a homozygous or heterozygous.  Mating of those fish with wild-type had revealed transgene transmission to the offspring following expected Mendelian laws. Thus, we found that the qTR-PCR to be effective for a rapid and precise determination of zygosity in transgenic fish. This technique could be useful in the establishment of breeding programs for mass transgenic fish production and in experiments in which zygosity effect could have a functional impact. Keywords: quantitative real-time PCR; zygosity; transgenic fish; mass production   ABSTRAK Identifikasi sigositas ikan transgenik biasanya dilakukan menggunakan analisa PCR dengan cetakan DNA genomik yang diekstraksi dari jaringan ikan hasil persilangan antara ikan transgenik dan ikan normal.   Metode ini memerlukan ikan dalam jumlah yang banyak, dan juga waktu serta tenaga.  Pendekatan baru untuk mengatasi masalah tersebut akan memberikan manfaat besar kepada peneliti bioteknologi perikanan.  Pada penelitian ini, kami menggunakan metode PCR real-time kuantitatif (krt-PCR untuk

  15. Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen.

    Directory of Open Access Journals (Sweden)

    Gianluigi Zaza

    Full Text Available The gut microbiome is the full set of microbes living in the gastrointestinal tract and is emerging as an important dynamic/fluid system that, if altered by environmental, dietetic or pharmacological factors, could considerably influence drug response. However, the immunosuppressive drug-induced modifications of this system are still poorly defined.We employed an innovative bioinformatics approach to assess differences in the whole-gut microbial metagenomic profile of 20 renal transplant recipients undergoing maintenance treatment with two different immunosuppressive protocols. Nine patients were treated with everolimus plus mycophenolate mofetil (EVE+MMF group, and 11 patients were treated with a standard therapy with tacrolimus plus mycophenolate mofetil (TAC+MMF group.A statistical analysis of comparative high-throughput data demonstrated that although similar according to the degree of Shannon diversity (alpha diversity at the taxonomic level, three functional genes clearly discriminated EVE+MMF versus TAC+MMF (cutoff: log2 fold change≥1, FDR≤0.05. Flagellar motor switch protein (fliNY and type IV pilus assembly protein pilM (pilM were significantly enriched in TAC+MMF-treated patients, while macrolide transport system mrsA (msrA was more abundant in patients treated with EVE+MMF. Finally, PERMANOVA revealed that among the variables analyzed and included in our model, only the consumption of sugar significantly influenced beta diversity.Our study, although performed on a relatively small number of patients, showed, for the first time, specific immunosuppressive-related effects on fecal microbiome of renal transplant recipients and it suggested that the analysis of the gut microbes community could represent a new tool to better understand the effects of drugs currently employed in organ transplantations. However, multicenter studies including healthy controls should be undertaken to better address this objective.

  16. Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen.

    Science.gov (United States)

    Zaza, Gianluigi; Dalla Gassa, Alessandra; Felis, Giovanna; Granata, Simona; Torriani, Sandra; Lupo, Antonio

    2017-01-01

    The gut microbiome is the full set of microbes living in the gastrointestinal tract and is emerging as an important dynamic/fluid system that, if altered by environmental, dietetic or pharmacological factors, could considerably influence drug response. However, the immunosuppressive drug-induced modifications of this system are still poorly defined. We employed an innovative bioinformatics approach to assess differences in the whole-gut microbial metagenomic profile of 20 renal transplant recipients undergoing maintenance treatment with two different immunosuppressive protocols. Nine patients were treated with everolimus plus mycophenolate mofetil (EVE+MMF group), and 11 patients were treated with a standard therapy with tacrolimus plus mycophenolate mofetil (TAC+MMF group). A statistical analysis of comparative high-throughput data demonstrated that although similar according to the degree of Shannon diversity (alpha diversity) at the taxonomic level, three functional genes clearly discriminated EVE+MMF versus TAC+MMF (cutoff: log2 fold change≥1, FDR≤0.05). Flagellar motor switch protein (fliNY) and type IV pilus assembly protein pilM (pilM) were significantly enriched in TAC+MMF-treated patients, while macrolide transport system mrsA (msrA) was more abundant in patients treated with EVE+MMF. Finally, PERMANOVA revealed that among the variables analyzed and included in our model, only the consumption of sugar significantly influenced beta diversity. Our study, although performed on a relatively small number of patients, showed, for the first time, specific immunosuppressive-related effects on fecal microbiome of renal transplant recipients and it suggested that the analysis of the gut microbes community could represent a new tool to better understand the effects of drugs currently employed in organ transplantations. However, multicenter studies including healthy controls should be undertaken to better address this objective.

  17. Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen

    Science.gov (United States)

    Dalla Gassa, Alessandra; Felis, Giovanna; Granata, Simona; Torriani, Sandra; Lupo, Antonio

    2017-01-01

    Background The gut microbiome is the full set of microbes living in the gastrointestinal tract and is emerging as an important dynamic/fluid system that, if altered by environmental, dietetic or pharmacological factors, could considerably influence drug response. However, the immunosuppressive drug-induced modifications of this system are still poorly defined. Methods We employed an innovative bioinformatics approach to assess differences in the whole-gut microbial metagenomic profile of 20 renal transplant recipients undergoing maintenance treatment with two different immunosuppressive protocols. Nine patients were treated with everolimus plus mycophenolate mofetil (EVE+MMF group), and 11 patients were treated with a standard therapy with tacrolimus plus mycophenolate mofetil (TAC+MMF group). Results A statistical analysis of comparative high-throughput data demonstrated that although similar according to the degree of Shannon diversity (alpha diversity) at the taxonomic level, three functional genes clearly discriminated EVE+MMF versus TAC+MMF (cutoff: log2 fold change≥1, FDR≤0.05). Flagellar motor switch protein (fliNY) and type IV pilus assembly protein pilM (pilM) were significantly enriched in TAC+MMF-treated patients, while macrolide transport system mrsA (msrA) was more abundant in patients treated with EVE+MMF. Finally, PERMANOVA revealed that among the variables analyzed and included in our model, only the consumption of sugar significantly influenced beta diversity. Conclusions Our study, although performed on a relatively small number of patients, showed, for the first time, specific immunosuppressive-related effects on fecal microbiome of renal transplant recipients and it suggested that the analysis of the gut microbes community could represent a new tool to better understand the effects of drugs currently employed in organ transplantations. However, multicenter studies including healthy controls should be undertaken to better address this

  18. Multimode entanglement assisted QKD through a free-space maritime channel

    Science.gov (United States)

    Gariano, John; Djordjevic, Ivan B.

    2017-10-01

    When using quantum key distribution (QKD), one of the trade-offs for security is that the generation rate of a secret key is typically very low. Recent works have shown that using a weak coherent source allows for higher secret key generation rates compared to an entangled photon source, when a channel with low loss is considered. In most cases, the system that is being studied is over a fiber-optic communication channel. Here a theoretical QKD system using the BB92 protocol and entangled photons over a free-space maritime channel with multiple spatial modes is presented. The entangled photons are generated from a spontaneous parametric down conversion (SPDC) source of type II. To employ multiple spatial modes, the transmit apparatus will contain multiple SPDC sources, all driven by the pump lasers assumed to have the same intensity. The receive apparatuses will contain avalanche photo diodes (APD), modeled based on the NuCrypt CPDS-1000 detector, and located at the focal point of the receive aperture lens. The transmitter is assumed to be located at Alice and Bob will be located 30 km away, implying no channel crosstalk will be introduced in the measurements at Alice's side due to turbulence. To help mitigate the effects of atmospheric turbulence, adaptive optics will be considered at the transmitter and the receiver. An eavesdropper, Eve, is located 15 km from Alice and has no control over the devices at Alice or Bob. Eve is performing the intercept resend attack and listening to the communication over the public channel. Additionally, it is assumed that Eve can correct any aberrations caused by the atmospheric turbulence to determine which source the photon was transmitted from. One, four and nine spatial modes are considered with and without applying adaptive optics and compared to one another.

  19. Näitused / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    1998-01-01

    Tallinna XI graafikatriennaal. Rotermanni soolaladu: "Puudutus"; Kunstihoone: "Puutujad"; Rahvusraamatukogu: Laste ja noorte graafikanäitus; Kastellaanimaja galerii: Wim Lamboo (s. 1949) "Eesti kunstnike portreed 1997" (fotograafia); Tallinna Botaanikaaed: "Maised rõõmud"; Rahvusraamatukogu: Antanas Sutkus (s. 1939) "Pro memoria" (fotograafia); Tammsaare majamuuseum: Eve Pärnaste "Ülelend" (maalid); Haapsalu Linnagalerii: Paul Allik "Seisundid" (aktimaalid).

  20. Breaking up with Deleuze: Desire and Valuing the Irreconcilable

    Science.gov (United States)

    Tuck, Eve

    2010-01-01

    In this article, Eve Tuck grapples with Gilles Deleuze's conceptualization of desire, finding it simultaneously generative and unsatisfying. Recognizing that Deleuze will not "say" what Tuck wants him to say about desire--that it is smart, and constitutes expertise--Tuck reasons that there is only one thing she can do: break up with Deleuze. The…

  1. Gegen sexismus- Gegen Rassismus. Two months after Colonia night

    Directory of Open Access Journals (Sweden)

    Laura Guidi

    2016-03-01

    Full Text Available Two months later the thefts and sexual assaults on women carried out by groups of men in the German city of Cologne on New Year’s Eve, the article focuses on the Media debate about the subject: from the Islamophobic interpretations to the opinions expressed by both Western and Islamic feminists.

  2. An Economic Rationale for the African Scramble. The Commercial Transition and the Commodity Price Boom of 1845-1885. NBER Working Paper 21213

    NARCIS (Netherlands)

    Frankema, E.H.P.; Williamson, J.G.; Woltjer, P.J.

    2015-01-01

    This is the first study to present a unified quantitative account of African commodity trade in the long 19th century from the zenith of the Atlantic slave trade (1790s) to the eve of World War II (1939). Drawing evidence from a new dataset on export and import prices, volumes, composition and net

  3. An Economic Rationale for the African Scramble : The Commercial Transition and the Commodity Price Boom of 1845-1885

    NARCIS (Netherlands)

    Frankema, Ewout; Williamson, Jeffrey; Woltjer, Pieter

    2015-01-01

    This is the first study to present a unified quantitative account of African commodity trade in the long 19th century from the zenith of the Atlantic slave trade (1790s) to the eve of World War II (1939). Drawing evidence from a new dataset on export and import prices, volumes, composition and net

  4. Õhus on elu : barokkmuusika ja nüüdistants Nikkolo peadisaineri loodud kostüümides. Väärtmuusika elamus pealinnast

    Index Scriptorium Estoniae

    2008-01-01

    15.-24. augustini annab kontserdisarjas "Eesti mõisad 2008" kuus kontsertetendust barokkmuusika ansambel Corelli Consort (vt. www.corelli.ee), kontsertetenduste kostüümid on loonud Ivo Nikkolo brändi naisteriiete peadisainer Eve Hanson. 17.-23. augustini toimub Tallinna Raekojas, Rootsi Mihkli kirikus ja Jaani kirikus Tallinna Kammermuusika festival (vt. www.plmf.ee)

  5. Short Trips and a Traverse

    Science.gov (United States)

    Cameron, Richard

    2012-01-01

    Dr. Cameron joined the Arctic Institute of North America in 1956 to participate in IGY-related activities in Antarctica. He served as Chief Glaciologist at Wilkes Station, on the coast of East Antarctica. This was a joint Navy-civilian operation consisting of 17 Navy personnel and 10 scientists. Specifically, his glaciological team consisted of two colleagues with whom he had worked before - Olav Loken in Norway in the summer of 1953, and John Molholm in Greenland in the summer of 1954. This team spent much of its time at a remote station established 80 kilometers (50 miles) inland, where they conducted both meteorological and glaciological studies. One of the glaciological studies entailed digging a 35-meter (approx.115-foot) vertical pit to study snow densification and stratigraphy. The assignment for the Navy Seabees was to first establish a joint US-NZ base at Cape Hallett and then go along the coast of East Antarctica and set up Wilkes Station.

  6. Health-Related Quality of Life in Obese Presurgery Patients with and without Binge Eating Disorder, and Subdiagnostic Binge Eating Disorders

    Directory of Open Access Journals (Sweden)

    Rita Marie Sandberg

    2013-01-01

    Full Text Available Objective. To study health-related quality of life (HRQoL in obese presurgery patients with binge eating disorder (BED and with subdiagnostic binge eating disorder (SBED compared to patients without eating disorders or SBED. Method. Participants were patients referred to St. Olavs University Hospital, Norway, for bariatric surgery. Eating Disorders in Obesity (EDO questionnaire was used to diagnose BED and SBED. Short-Form Health Survey (SF-12 assessed health-related quality of life. Questionnaires were returned by 160 of 209 patients. The present study sample consisted of 143 patients (103 women and 40 men as 17 patients did not complete the SF-12. Results. Patients with BED and patients with SBED both had significantly lower mental HRQoL, but not physical HRQoL, compared to patients without eating disorders. Discussion. The findings indicate that obese presurgery patients with BED, and also SBED, may have special treatment needs in regard to their mental health.

  7. Bullying behaviour among Norwegian adolescents: psychiatric diagnoses and school well-being in a clinical sample.

    Science.gov (United States)

    Hansen, Hanne Hoff; Hasselgård, Cecilie Edh; Undheim, Anne Mari; Indredavik, Marit Sæbø

    2014-07-01

    Few studies have focused the association between bullying and psychiatric disorders in clinical samples. The aim of this study was to examine if bullying behaviour was associated with psychiatric disorders and school well-being. The cross-sectional study was part of a health survey at St. Olav's University Hospital. The sample consisted of 685 adolescent patients aged 13-18 years who completed an electronic questionnaire. Clinical diagnoses were collected from clinical records. In this clinical psychiatric sample, 19% reported being bullied often or very often, and 51% reported being bullied from time to time. Logistic regression analyses showed associations between being a victim and having a mood disorder, and between being involved in bullying behaviour and reporting lower scores on school well-being. No difference was found in bullying behaviour on gender, age and SES. The risk of being a victim was high among adolescents in this clinical sample, especially among patients with mood disorders. Any involvement in bullying behaviour was associated with reduced school well-being.

  8. Endogenous viral elements in animal genomes.

    Directory of Open Access Journals (Sweden)

    Aris Katzourakis

    2010-11-01

    Full Text Available Integration into the nuclear genome of germ line cells can lead to vertical inheritance of retroviral genes as host alleles. For other viruses, germ line integration has only rarely been documented. Nonetheless, we identified endogenous viral elements (EVEs derived from ten non-retroviral families by systematic in silico screening of animal genomes, including the first endogenous representatives of double-stranded RNA, reverse-transcribing DNA, and segmented RNA viruses, and the first endogenous DNA viruses in mammalian genomes. Phylogenetic and genomic analysis of EVEs across multiple host species revealed novel information about the origin and evolution of diverse virus groups. Furthermore, several of the elements identified here encode intact open reading frames or are expressed as mRNA. For one element in the primate lineage, we provide statistically robust evidence for exaptation. Our findings establish that genetic material derived from all known viral genome types and replication strategies can enter the animal germ line, greatly broadening the scope of paleovirological studies and indicating a more significant evolutionary role for gene flow from virus to animal genomes than has previously been recognized.

  9. Electronic properties of mixed molybdenum dichalcogenide MoTeSe: LCAO calculations and Compton spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Ahuja, Ushma [Department of Electrical Engineering, Veermata Jijabai Technological Institute, H. R. Mahajani Marg, Matunga (East), Mumbai 400019, Maharashtra (India); Kumar, Kishor; Joshi, Ritu [Department of Physics, University College of Science, M.L. Sukhadia University, Udaipur 313001, Rajasthan (India); Bhavsar, D.N. [Department of Physics, Bhavan' s Seth R.A. College of Science, Khanpur, Ahmedabad 380001, Gujarat (India); Heda, N.L., E-mail: nlheda@yahoo.co.in [Department of Pure and Applied Physics, University of Kota, Kota 324007, Rajasthan (India)

    2016-07-01

    We have employed linear combination of atomic orbitals (LCAO) method to compute the Mulliken’s population (MP), energy bands, density of states (DOS) and Compton profiles for hexagonal MoTeSe. The density functional theory (DFT) and hybridization of Hartree-Fock with DFT (B3LYP) have been used within the LCAO approximation. Performance of theoretical models has been tested by comparing the theoretical momentum densities with the experimental Compton profile of MoTeSe measured using {sup 137}Cs Compton spectrometer. It is seen that the B3LYP prescription gives a better agreement with the experimental data than other DFT based approximations. The energy bands and DOS depict an indirect band gap character in MoTeSe. In addition, a relative nature of bonding in MoTeSe and its isovalent MoTe{sub 2} is discussed in terms of equal-valence-electron-density (EVED) profiles. On the basis of EVED profiles it is seen that MoTeSe is more covalent than MoTe{sub 2}.

  10. Don’t call it a closure!

    CERN Document Server

    Rosaria Marraffino

    2015-01-01

    During the Laboratory’s annual closure, some members of the personnel joined their families, others seized the chance to travel the world. The Restaurants were closed, the corridors were dark and the heating was turned off in most of the buildings. However, a lot of people spent the Christmas break working on site and the Bulletin would like to dedicate this first article of the new year to them all!   In the CERN Control Centre (CCC), each shift had two people in position to guarantee regular 24/7 service and to intervene in case of need. Gildas Langlois and Rodolphe Maillet, CCC operators from the Beams Department, spent Christmas Eve there and celebrated it with a cake. “I volunteered to work during the holidays in order to allow colleagues to stay with their families,” says Maillet. On New Year’s Eve, it was Julien Pache and Jean-Michel Nonglaton’s turn to spend the night at work. They had a nice dinner with a CCC-made fondue and some desse...

  11. Endogenous hepadnaviruses, bornaviruses and circoviruses in snakes.

    Science.gov (United States)

    Gilbert, C; Meik, J M; Dashevsky, D; Card, D C; Castoe, T A; Schaack, S

    2014-09-22

    We report the discovery of endogenous viral elements (EVEs) from Hepadnaviridae, Bornaviridae and Circoviridae in the speckled rattlesnake, Crotalus mitchellii, the first viperid snake for which a draft whole genome sequence assembly is available. Analysis of the draft assembly reveals genome fragments from the three virus families were inserted into the genome of this snake over the past 50 Myr. Cross-species PCR screening of orthologous loci and computational scanning of the python and king cobra genomes reveals that circoviruses integrated most recently (within the last approx. 10 Myr), whereas bornaviruses and hepadnaviruses integrated at least approximately 13 and approximately 50 Ma, respectively. This is, to our knowledge, the first report of circo-, borna- and hepadnaviruses in snakes and the first characterization of non-retroviral EVEs in non-avian reptiles. Our study provides a window into the historical dynamics of viruses in these host lineages and shows that their evolution involved multiple host-switches between mammals and reptiles. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  12. Official holidays in 2010 and end-of-year closure 2010/2011

    CERN Document Server

    HR Department

    2010-01-01

    (Application of Articles R II 4.38 and R II 4.39 of the Staff Regulations) Official holidays in 2010 (in addition to the special leave during the annual closure): Friday 1st January\t(New year) Friday 2nd April\t(Good Friday) Monday, 5th April\t(Easter Monday) Thursday 13th May\t(Ascension day) Friday 14th May\t(compensation granted for 1st May) Monday 24th May\t(Whit Monday) Thursday 9th September\t(“Jeûne genevois”) Thursday 23rd December\t(compensation granted for 25th December, Christmas) Friday 24th December\t(Christmas Eve) Thursday 30th December\t(compensation granted for 1st January 2011, New Year) Friday 31st December\t(New Year’s Eve) Annual closure of the site of the Organization during the Christmas holidays and day of special leave granted by the Director-General : The Laboratory will be closed from Wednesday, 22nd December 2010 to Tuesday, 4th January 2011 inclusive (without deduction of annual leave). The first worki...

  13. Press Conference: Update on the search for the Higgs boson at CERN on 4 July 2012

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    PRESS CONFERENCE Update on the search for the Higgs boson at CERN on the eve of the ICHEP 2012 Conference Geneva, 22 June 2012.  Dear Journalists, CERN will hold a scientific seminar at 9:00 CEST on 4 July to deliver the latest update in the search for the Higgs boson. At this seminar, coming on the eve of the year’s major particle physics conference, ICHEP, in Melbourne, the ATLAS and CMS experiments will deliver the preliminary results of their 2012 data analysis. The seminar begins at 9:00 CEST. The auditorium in which the seminar will be held is reserved for CERN personnel and researchers from the laboratory’s user community, but a video stream will be relayed to another auditorium. A press conference will follow the seminar in presence of CERN Director General, Rolf Heuer, ATLAS spokesperson, Fabiola Gianotti and CMS spokesperson, Joe Incandela. Media wishing to attend the press conference on CERN site should fill in the registration form. Both the seminar a...

  14. IT Services Availability during the CERN Annual Closure 2005

    CERN Multimedia

    2005-01-01

    Mail, CERN Windows (NICE), Web services, LXPLUS, LXBATCH, AFS, the automated tape devices, Castor, CDS Search, Submit and Agenda, InDiCo, EDMS (in collaboration with TS Department), Campus Network, Remedy, and Security services will be available during the CERN annual closure. All production databases will remain available (but not development databases such as devdb and devdb10). Problems occuring on scheduled services should be addressed within about half a day, except around Christmas Eve and Christmas Day (24 and 25 December) and New Year's Eve and New Year's Day (31 December and 1st January). As far as administrative computings services are concerned, ERT (Electronic Recruitment Tool) and PPT (Project Progress Tracking) for EGEE will be the only operational services; all other AIS applications such as EDH, CET, HRT, etc. will be unavailable from Wednesday 21/12 12:00 to Thursday 5/01/2005 8:00. The CERN LCG Production Services will be run on a 'best effort” basis. All other services (such as the ...

  15. Mutations in POGLUT1, Encoding Protein O-Glucosyltransferase 1, Cause Autosomal-Dominant Dowling-Degos Disease

    Science.gov (United States)

    Basmanav, F. Buket; Oprisoreanu, Ana-Maria; Pasternack, Sandra M.; Thiele, Holger; Fritz, Günter; Wenzel, Jörg; Größer, Leopold; Wehner, Maria; Wolf, Sabrina; Fagerberg, Christina; Bygum, Anette; Altmüller, Janine; Rütten, Arno; Parmentier, Laurent; El Shabrawi-Caelen, Laila; Hafner, Christian; Nürnberg, Peter; Kruse, Roland; Schoch, Susanne; Hanneken, Sandra; Betz, Regina C.

    2014-01-01

    Dowling-Degos disease (DDD) is an autosomal-dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation. We previously identified loss-of-function mutations in KRT5 but were only able to detect pathogenic mutations in fewer than half of our subjects. To identify additional causes of DDD, we performed exome sequencing in five unrelated affected individuals without mutations in KRT5. Data analysis identified three heterozygous mutations from these individuals, all within the same gene. These mutations, namely c.11G>A (p.Trp4∗), c.652C>T (p.Arg218∗), and c.798-2A>C, are within POGLUT1, which encodes protein O-glucosyltransferase 1. Further screening of unexplained cases for POGLUT1 identified six additional mutations, as well as two of the above described mutations. Immunohistochemistry of skin biopsies of affected individuals with POGLUT1 mutations showed significantly weaker POGLUT1 staining in comparison to healthy controls with strong localization of POGLUT1 in the upper parts of the epidermis. Immunoblot analysis revealed that translation of either wild-type (WT) POGLUT1 or of the protein carrying the p.Arg279Trp substitution led to the expected size of about 50 kDa, whereas the c.652C>T (p.Arg218∗) mutation led to translation of a truncated protein of about 30 kDa. Immunofluorescence analysis identified a colocalization of the WT protein with the endoplasmic reticulum and a notable aggregating pattern for the truncated protein. Recently, mutations in POFUT1, which encodes protein O-fucosyltransferase 1, were also reported to be responsible for DDD. Interestingly, both POGLUT1 and POFUT1 are essential regulators of Notch activity. Our results furthermore emphasize the important role of the Notch pathway in pigmentation and keratinocyte morphology. PMID:24387993

  16. Keratins as components of the enamel organic matrix

    Science.gov (United States)

    Duverger, Olivier; Beniash, Elia; Morasso, Maria I.

    2016-01-01

    Dental enamel is a hardest tissue in the human body, and although it starts as a tissue rich in proteins, by the time of eruption of the tooth in the oral cavity only a small fraction of the protein remains. While this organic matrix of enamel represents less than 1% by weight it plays essential roles in improving both toughness and resilience to chemical attacks. Despite the fact that the first studies of the enamel matrix began in the 19th century its exact composition and mechanisms of its function remain poorly understood. It was proposed that keratin or a keratin-like primitive epithelial component exists in mature enamel, however due to the extreme insolubility of its organic matrix the presence of keratins there was never clearly established. We have recently identified expression of a number of hair keratins in ameloblasts, the enamel secreting cells, and demonstrated their incorporation into mature enamel. Mutation in epithelial hair keratin KRT75 leads to a skin condition called pseudofollicularis barbae. Carriers of this mutation have an altered enamel structure and mechanical properties. Importantly, these individuals have a much higher prevalence of caries. To the best of our knowledge, this is the first study showing a direct link between a mutation in a protein-coding region of a gene and increased caries rates. In this paper we present an overview of the evidence of keratin-like material in enamel that has accumulated over the last 150 years. Furthermore, we propose potential mechanisms of action of KTR75 in enamel and highlight the clinical implications of the link between mutations in KRT75 and caries. Finally, we discuss the potential use of keratins for enamel repair. PMID:26709044

  17. Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk

    Science.gov (United States)

    Permuth, Jennifer B.; Pirie, Ailith; Ann Chen, Y.; Lin, Hui-Yi; Reid, Brett M.; Chen, Zhihua; Monteiro, Alvaro; Dennis, Joe; Mendoza-Fandino, Gustavo; Anton-Culver, Hoda; Bandera, Elisa V.; Bisogna, Maria; Brinton, Louise; Brooks-Wilson, Angela; Carney, Michael E.; Chenevix-Trench, Georgia; Cook, Linda S.; Cramer, Daniel W.; Cunningham, Julie M.; Cybulski, Cezary; D’Aloisio, Aimee A.; Anne Doherty, Jennifer; Earp, Madalene; Edwards, Robert P.; Fridley, Brooke L.; Gayther, Simon A.; Gentry-Maharaj, Aleksandra; Goodman, Marc T.; Gronwald, Jacek; Hogdall, Estrid; Iversen, Edwin S.; Jakubowska, Anna; Jensen, Allan; Karlan, Beth Y.; Kelemen, Linda E.; Kjaer, Suzanne K.; Kraft, Peter; Le, Nhu D.; Levine, Douglas A.; Lissowska, Jolanta; Lubinski, Jan; Matsuo, Keitaro; Menon, Usha; Modugno, Rosemary; Moysich, Kirsten B.; Nakanishi, Toru; Ness, Roberta B.; Olson, Sara; Orlow, Irene; Pearce, Celeste L.; Pejovic, Tanja; Poole, Elizabeth M.; Ramus, Susan J.; Anne Rossing, Mary; Sandler, Dale P.; Shu, Xiao-Ou; Song, Honglin; Taylor, Jack A.; Teo, Soo-Hwang; Terry, Kathryn L.; Thompson, Pamela J.; Tworoger, Shelley S.; Webb, Penelope M.; Wentzensen, Nicolas; Wilkens, Lynne R.; Winham, Stacey; Woo, Yin-Ling; Wu, Anna H.; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Phelan, Catherine M.; Schildkraut, Joellen M.; Berchuck, Andrew; Goode, Ellen L.; Pharoah, Paul D. P.; Sellers, Thomas A.

    2016-01-01

    Rare and low frequency variants are not well covered in most germline genotyping arrays and are understudied in relation to epithelial ovarian cancer (EOC) risk. To address this gap, we used genotyping arrays targeting rarer protein-coding variation in 8,165 EOC cases and 11,619 controls from the international Ovarian Cancer Association Consortium (OCAC). Pooled association analyses were conducted at the variant and gene level for 98,543 variants directly genotyped through two exome genotyping projects. Only common variants that represent or are in strong linkage disequilibrium (LD) with previously-identified signals at established loci reached traditional thresholds for exome-wide significance (P  P≥5.0 ×10 − 7) were detected for rare and low-frequency variants at 16 novel loci. Four rare missense variants were identified (ACTBL2 rs73757391 (5q11.2), BTD rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66). Genes most strongly associated with EOC risk included ACTBL2 (PAML = 3.23 × 10 − 5; PSKAT-o = 9.23 × 10 − 4) and KRT13 (PAML = 1.67 × 10 − 4; PSKAT-o = 1.07 × 10 − 5), reaffirming variant-level analysis. In summary, this large study identified several rare and low-frequency variants and genes that may contribute to EOC susceptibility, albeit with possible small effects. Future studies that integrate epidemiology, sequencing, and functional assays are needed to further unravel the unexplained heritability and biology of this disease. PMID:27378695

  18. Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis.

    Science.gov (United States)

    Xiao, Yuan; Yuan, Wentao; Yu, Bo; Guo, Yan; Xu, Xu; Wang, Xinqiong; Yu, Yi; Yu, Yi; Gong, Biao; Xu, Chundi

    2017-12-01

    To identify causal mutations in certain genes in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). After patients were enrolled (CP, 55; ARP, 14) and their clinical characteristics were investigated, we performed next-generation sequencing to detect nucleotide variations among the following 10 genes: cationic trypsinogen protease serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1), cystic fibrosis transmembrane conductance regulator gene (CFTR), chymotrypsin C (CTRC), calcium-sensing receptor (CASR), cathepsin B (CTSB), keratin 8 (KRT8), CLAUDIN 2 (CLDN2), carboxypeptidase A1 (CPA1), and ATPase type 8B member 1 (ATP8B1). Mutations were searched against online databases to obtain information on the cause of the diseases. Certain novel mutations were analyzed using the SIFT2 and Polyphen-2 to predict the effect on protein function. There were 45 patients with CP and 10 patients with ARP who harbored 1 or more mutations in these genes; 45 patients had at least 1 mutation related to pancreatitis. Mutations were observed in the PRSS1, SPINK1, and CFTR genes in 17 patients, the CASR gene in 5 patients, and the CTSB, CTRC, and KRT8 genes in 1 patient. Mutations were not found in the CLDN, CPA1, or ATP8B1 genes. We found that mutations in SPINK1 may increase the risk of pancreatic duct stones (OR, 11.07; P = .003). The patients with CFTR mutations had a higher level of serum amylase (316.0 U/L vs 92.5 U/L; P = .026). Mutations, especially those in PRSS1, SPINK1, and CFTR, accounted for the major etiologies in Chinese children with CP or ARP. Children presenting mutations in the SPINK1 gene may have a higher risk of developing pancreatic duct stones. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Transcriptomic dissection of tongue squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Schwartz Joel L

    2008-02-01

    Full Text Available Abstract Background The head and neck/oral squamous cell carcinoma (HNOSCC is a diverse group of cancers, which develop from many different anatomic sites and are associated with different risk factors and genetic characteristics. The oral tongue squamous cell carcinoma (OTSCC is one of the most common types of HNOSCC. It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC. Results Genome-wide transcriptomic profiles were obtained for 53 primary OTSCCs and 22 matching normal tissues. Genes that exhibit statistically significant differences in expression between OTSCCs and normal were identified. These include up-regulated genes (MMP1, MMP10, MMP3, MMP12, PTHLH, INHBA, LAMC2, IL8, KRT17, COL1A2, IFI6, ISG15, PLAU, GREM1, MMP9, IFI44, CXCL1, and down-regulated genes (KRT4, MAL, CRNN, SCEL, CRISP3, SPINK5, CLCA4, ADH1B, P11, TGM3, RHCG, PPP1R3C, CEACAM7, HPGD, CFD, ABCA8, CLU, CYP3A5. The expressional difference of IL8 and MMP9 were further validated by real-time quantitative RT-PCR and immunohistochemistry. The Gene Ontology analysis suggested a number of altered biological processes in OTSCCs, including enhancements in phosphate transport, collagen catabolism, I-kappaB kinase/NF-kappaB signaling cascade, extracellular matrix organization and biogenesis, chemotaxis, as well as suppressions of superoxide release, hydrogen peroxide metabolism, cellular response to hydrogen peroxide, keratinization, and keratinocyte differentiation in OTSCCs. Conclusion In summary, our study provided a transcriptomic signature for OTSCC that may lead to a diagnosis or screen tool and provide the foundation for further functional validation of these specific candidate genes for OTSCC.

  20. An Intelligence Collection Management Model.

    Science.gov (United States)

    1984-06-01

    classification of inteligence collection requirements in terms of. the a-.- metnodo"c, .ev--e in Chaster Five. 116 APPgENDIX A A METHOD OF RANKING...of Artificial Intelligence Tools and Technigues to!TN’X n~l is n rs aa~emfft-.3-ufnyva: ’A TZ Ashby W. Ecss. An Introduction to Cybernetics. New York

  1. Hea tahte mängud Helsingis / Hanno Soans

    Index Scriptorium Estoniae

    Soans, Hanno, 1974-

    2003-01-01

    3. ja 4. XII Kiasmas toimunud seminarist "Institutsioonid ruudus", mis tutvustas kümmet kaasaegse kunstiga tegelevat institutsiooni Euroopas ja nende uusi töömudeleid seminari, workshopide ja näituse abil. Eestit esindas Silva Lutsu sketsh Tellervo Kalleineni videos "In the Middle of the Movie", seminaril olid H. Soans, Reiu Tüür, Eve Kiiler

  2. The Big Apple's Core: Exploring Manhattan

    Science.gov (United States)

    Groce, Eric C.; Groce, Robin D.; Colby, Susan

    2005-01-01

    Children are exposed to a wide variety of images related to New York City through various media outlets. They may have seen glimpses of Manhattan by watching movies such as Spiderman or Stuart Little or by taking in annual television events such as the Macy's Thanksgiving Day Parade or the Times Square New Year's Eve celebration. Additionally,…

  3. Woodrow Wilson: Prophet of Peace. Teaching with Historic Places.

    Science.gov (United States)

    Goehner, Thomas B.

    This lesson describes President Woodrow Wilson's struggle with and his ultimate failure at achieving lasting world peace through the League of Nations. The lesson focuses on November 23, 1923, the eve of the fifth anniversary of the Armistice that concluded World War I, when a frail and ill Wilson was ready to deliver a commemorative address by…

  4. Rational and Boundedly Rational Behavior in a Binary Choice Sender-Receiver Game

    Science.gov (United States)

    Landi, Massimiliano; Colucci, Domenico

    2008-01-01

    The authors investigate the strategic rationale behind the message sent by Osama bin Laden on the eve of the 2004 U.S. Presidential elections. They model this situation as a signaling game in which a population of receivers takes a binary choice, the outcome is decided by majority rule, sender and receivers have conflicting interests, and there is…

  5. Nuclear energy in limelight of publicity. [Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Bergmaier, H

    1978-12-12

    The future of nuclear energy is discussed considering economical, political and environmental protection questions raised in Switzerland on eve of the national referendum held in February 1979. It is argued that the objections are unfounded and it is shown that Switzerland cannot afford to be without nuclear energy needed to maintain the required rate of growth of the economy.

  6. Suspending Damage: A Letter to Communities

    Science.gov (United States)

    Tuck, Eve

    2009-01-01

    In this open letter, Eve Tuck calls on communities, researchers, and educators to reconsider the long-term impact of "damage-centered" research--research that intends to document peoples' pain and brokenness to hold those in power accountable for their oppression. This kind of research operates with a flawed theory of change: it is often used to…

  7. München ei ole ainult Oktoberfest / Albert Trapeezh

    Index Scriptorium Estoniae

    Trapeež, Albert, pseud., 1947-

    2005-01-01

    Eesti nüüdiskunsti näitusest Müncheni kunstikeskuses Aktionsforum. Osalesid Siim-Tanel Annus, Jaan Elken, Jüri Kass, Ülle Marks, Eve Kask, Lennart Mänd, Tiiu Kirsipuu, Leonhard Lapin, Raul Meel, Liina Siib, Andres Tolts ja Urmas Viik. Näituse kataloogi eestipoolsed tekstid kirjutas Harry Liivrand. Müncheni moodsaimast kunstikeskusest Pinakothek der Moderne'ist

  8. Quantum cryptography as a retrodiction problem.

    Science.gov (United States)

    Werner, A H; Franz, T; Werner, R F

    2009-11-27

    We propose a quantum key distribution protocol based on a quantum retrodiction protocol, known as the Mean King problem. The protocol uses a two way quantum channel. We show security against coherent attacks in a transmission-error free scenario, even if Eve is allowed to attack both transmissions. This establishes a connection between retrodiction and key distribution.

  9. Rice University: Building an Academic Center for Nonprofit Education

    Science.gov (United States)

    Seaworth, Angela

    2012-01-01

    According to the author, the setting for their nonprofit education center was close to ideal: Support from a dean who cares deeply about nonprofit organizations; encouragement from the university and its renewed focus on reaching beyond its walls on the eve of its centennial; and a generous gift from alumni who have been affiliated with the…

  10. Inimesed, kes on armunud filmi / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2001-01-01

    UNICA festivali korraldaja Jaak Järvise abiga antud ülevaade Tallinnas 3.-12. augustini toimuvast UNICA 63. ülemaailmsest amatöörfilmide festivalist. Ka nimekiri selle raames toimunud üheminutiliste filmide maailmameistrivõistluste tulemustest, kus ühe kolmanda preemia sai Tõnu Aru ja Eve Esteri "Friendly". Põhiprogrammis võistleb ka Tõnu Aru "Elu on niisugune"

  11. The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARγ on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes

    DEFF Research Database (Denmark)

    Stage, Tore B; Christensen, Mette M H; Feddersen, Søren

    2013-01-01

    OBJECTIVE: The aim of this study was to examine the effect of single nucleotide polymorphisms in CYP2C8, LPIN1, PPARGC1A and PPARγ on rosiglitazone's (i) trough steady-state plasma concentration (C(ss,min)), (ii) on glycosylated haemoglobin A1c (HbA1c) and (iii) the risk of developing adverse eve...

  12. Arhitektuurivõistlus 21. sajandi kodu Lahemaal

    Index Scriptorium Estoniae

    2012-01-01

    Hinnang peapreemia pälvinud töödele "Ranna-Niidu" (Mikk Mutso), "Sirmik" (Maarja Elm, Sten Ader), "Akupunktuur" (Lidia Zarudnaja, Martin Noorväli, Urmas Paul) ja "Adaptsioon" (Kristjan Tõlk, Olavi Kukk, Heleriin Vaher) ning eripreemia pälvinud töödele "Greg" (Eve Komp, Artur Staškevitš) ja "Potjomkin" (Johan Tali)

  13. Tallinna ülikoolil on 16 uut doktorit

    Index Scriptorium Estoniae

    2007-01-01

    Aasta jooksul on Tallinna Ülikoolis doktorikraadi kaitsnud 16 inimest. Humanitaarteaduste doktoriteks promoveeritakse Inna Adamson, Maris Saagpakk, Anne Lange, Julia Tofantšuk, Janis Ešots ja Grigori Utgof; kasvatusteaduste doktoriteks Veronika Nagel, Eve Eisenschmidt, Tuuli Oder, Kristina Nugin, Inga Mutso, Tiina Selke ja Boriss Bazanov; loodusteaduste doktoriks Tiit Maran; ning sotsiaalteaduste doktoriteks Signe Dobelniece ja Marge Unt

  14. Animeerija ei pea olema da Vinci / Eve Tisler

    Index Scriptorium Estoniae

    Tisler, Eve

    2006-01-01

    Sügisest saab Eesti Kunstiakadeemia meediateaduskonnas fotograafia, stenograafia ja graafilise disaini kõrval õppida ka animatsiooni. Osakonna erakorraline dotsent on Ülo Pikkov ning professor Priit Pärn annab kursust loovusest

  15. Filmikool valis püha lehma / Eve Tisler

    Index Scriptorium Estoniae

    Tisler, Eve

    2007-01-01

    Balti Filmi- ja Meediakool kuulutas välja filmifestivali "Holy Cow" võitjad, esikoha vääriliseks tunnistati Liina Paakspuu film "Ettevõtja". Kokku laekus konkursile 40 mängu-, dokumentaal- ja eksperimentaalfilmi ning telesaadet

  16. Õpetaja käitumine tunnis / Eve Eisenschmidt

    Index Scriptorium Estoniae

    Eisenschmidt, Eve, 1963-

    2001-01-01

    Õpetaja domineerivast tegevusest õppetunnis, erinevast suhtumisest õpilastesse, rühmatöö korraldamisest, aja kasutamisest tunnis, õpetaja suhtumisest õppeainetesse ja osaoskustesse, adekvaatsest eneseanalüüsist

  17. Olla originaalne ja tähelepandud / Eve Sepp

    Index Scriptorium Estoniae

    Sepp, Eve

    1989-01-01

    Tuntud daamide originaalehetest - tekstiilikunstnik Anna Gerretzi Ülle Kõutsi valmistatud kõrvarõngad, disainer Helle Gansi Katrin Amose loodud rinnanõel, raamatukogudirektrissi Anne Randeli Tiina Käeseli loodud ehted, arhitekt Marka Lõokese Kadri Mälgu loodud komplekt, kunstiteadlase Krista Kodrese Tiina Käeseli loodud komplekt, grimeerija Krista Pärdi abikaasa Rein Metsa loodud ehted

  18. Tallinnas möllas 2208 tantsijat / Eveli Rebane

    Index Scriptorium Estoniae

    Rebane, Eveli

    2007-01-01

    Kalevi spordihallis 14.-15. aprillil toimunud rahvusvahelised tantsuvõistlused "Estonian Open Cup" ja "Baltic Cup". Võistlusi korraldab IDO (International Dance Organisation) Eesti haru. "Baltic Cupi" võitjaks tuli Kuressaare tantsutrupp Semiir

  19. Kõik failid on juba alla laetud! / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2008-01-01

    Berliini iga-aastasest kunsti- ja digitaalkultuuri festivalist "Transmediale" alapealkirjaga "Conspire...", kus käsitleti privaatsuse kadumist, info vaba levikut, hirmu, kopeeritavust, unikaalsust. Võitis ameeriklaste Julia Meltzeri ja David Thorne video "Not a Matter of If but When". Raivo Kelomehe kommentaarid

  20. Eve Mutso reklaamib Šoti balletti / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2005-01-01

    Endine Estonia baleriin E. Mutso, kes tantsib solistina Shoti Balletis, on nomineeritud rahvuslikule tantsuauhinnale National Dance Awards kui aasta parim naistantsija. Tema kohta avaldab arvamust ka Londoni tantsuajakirjanik S. Sweeney

  1. Veresaun Afganistanis / Eve Heinla, Mihkel Niglas, Arvo Uustalu

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2009-01-01

    Afganistanis hukkusid Eesti kaitseväelased Eerik Salmus ja Raivis Kang. Vt. samas: Langenutele teenetemärk. President Toomas Hendrik Ilves andis veebel Eerik Salmusele ja seersant Raivis Kangile postuumselt Kotkaristi kuldristi mõõkadega ja tegi kaitseministeeriumis sissekande kaastundeavalduste raamatusse

  2. On The Eve Of IYA2009 In Canada

    Science.gov (United States)

    Hesser, James E.; Breland, K.; Hay, K.; Lane, D.; Lacasse, R.; Lemay, D.; Langill, P.; Percy, J.; Welch, D.; Woodsworth, A.

    2009-01-01

    Local events organized by astronomy clubs, colleges and universities across Canada will softly launch IYA on Saturday, 10 January and begin building awareness of opportunities for every Canadian to experience a `Galileo Moment’ in 2009. The launch typifies our `grass roots’ philosophy based upon our strong partnership of amateurs and professionals which already represents an IYA legacy. In this poster we anticipate the activities of the first half of 2009 and exhibit the educational and public outreach materials and programs we have produced in both official languages, e.g., Astronomy Trading Cards, Mary Lou's New Telescope, Star Finder, etc. Some of these play central roles in our tracking of participation, including allowing people to register to have their name launched into space in 2010. Several contests for youth are underway, with the prize in one being an hour of Gemini telescope observing. In the first half of 2009 some 30,000 grade 6 students will experience `Music of the Spheres’ astronomical orchestral programming conducted by Galileo (a.k.a. Tania Miller, Victoria Symphony). Audiences in Canada and the US will experience Taflemusik's marvelous new soundscape of music and words exploring the deep connections between astronomy and Baroque-era music. An Astronomy Kit featuring Galileoscope for classroom and astronomy club EPO will be tested. Canada Post will issue two stamps during 100 Hours of Astronomy. A new production, Galileo Live!, by Canadian planetaria involving live actors will premier, as will the national Galileo Legacy Lectures in which top astronomers familiarize the public with forefront research being done in Canada. Image exhibits drawing upon material generated by Canadian astronomers and artists, as well as from the IAU Cornerstones, FETTU and TWAN, are opening in malls and airports early in 2009. We will present the latest information about these and other events.

  3. Rüütel, Halonen ja Brown? / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2006-01-01

    James Browni kontserdil 27. juulil Tallinna laulukaare all loodetakse kaasa tõmmata ka poliitikud. Ameerika soulmuusik James Brown esitas president Arnold Rüütlile kutse laulda koos temaga duetti. Lisa: Rüütlil siiani Annaniga laulmata

  4. Eve and David / Honor©♭ de Balzac

    Trove (Australia)

    Balzac, Honor©♭ de, 1799-1850

    2007-01-01

    ... for this deep thinker he must invent a method of making cheap paper and that quickly he must make the discovery in fact in order to apply the proceeds to the needs of the household and of the business ...

  5. Edison's Modern Legend in Villiers' L'Eve future

    Directory of Open Access Journals (Sweden)

    Ana Oancea

    2012-03-01

    International and Electrical Expositions of the 1870s and 1880s. Villiers’ depiction of the protagonist as astute showman does not, however, amount to a criticism of his technological abilities. Instead, the author’s emphasis on these characteristics goes to solidify his legend as a modern, unique tale of economic success through applied science.

  6. Atom's eve: ending the nuclear age - an anthology

    International Nuclear Information System (INIS)

    Reader, M.; Hardert, R.A.; Moulton, G.L.

    1980-01-01

    In this volume over forty experts and advocates examine the implications of the nuclear fuel cycle and its hazards to critical human issues. They address such matters as the link between cancer and low level radiation, the failure to find reliable ways to dispose of radioactive wastes, known genetic effects of radiation, the political repression necessary to maintain a nuclear society, and all the other politics and controversies in the growing movement against nuclear power. Included are a checklist of energy alternatives and organizations, a calendar of major nuclear events from 1945 to the present, and a nuclear bibliography of books and audiovisual material

  7. Exosomes in Development and Therapy of Malignant Mesothelioma

    Science.gov (United States)

    2015-09-01

    exosomes. B. Dynamic light scattering (DLS) showing the size of the exosomes. 6 Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 H4_HUMAN Keratin, type I...cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 K1C9_HUMAN Isoform 2 of Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC sp|Q00610-2|CLH1_HUMAN (+1...Clathrin heavy chain 2 OS=Homo sapiens GN=CLTCL1 PE=1 SV=2 sp|P53675|CLH2_HUMAN Cluster of Histone H2A type 1-B/E OS=Homo sapiens GN=HIST1H2AB PE=1 SV

  8. Utility of a Novel Three-Dimensional and Dynamic (3DD Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

    Directory of Open Access Journals (Sweden)

    Anusha Ande

    2018-05-01

    Full Text Available Background: Emergence of Human epidermal growth factor receptor 2 (HER2 therapy resistance in HER2-positive (HER2+ breast cancer (BC poses a major clinical challenge. Mechanisms of resistance include the over-activation of the PI3K/mTOR and Src pathways. This work aims to investigate a novel combination therapy that employs paclitaxel (PAC, a mitotic inhibitor, with everolimus (EVE, an mTOR inhibitor, and dasatinib (DAS, an Src kinase inhibitor, as a modality to overcome resistance.Methods: Static (two dimensional, 2D and three-dimensional dynamic (3DD cell culture studies were conducted using JIMT-1 cells, a HER2+ BC cell line refractory to HER2 therapies. Cell viability and caspase-3 expression were examined after JIMT-1 cell exposure to agents as monotherapy or in combination using a 2D setting. A pharmacokinetic/pharmacodynamic (PK/PD combination study with PAC+DAS+EVE was conducted over 3 weeks in a 3DD setting. PAC was administered into the system via a 3 h infusion followed by the addition of a continuous infusion of EVE+DAS 24 h post-PAC dosing. Cell counts and caspase-3 expression were quantified every 2 days. A semi-mechanistic PK/PD model was developed using the 2D data and scaled up to capture the 3DD data. The final model integrated active caspase-3 as a biomarker to bridge between drug exposures and cancer cell dynamics. Model fittings were performed using Monolix software.Results: The triple combination significantly induced caspase-3 activity in the 2D cell culture setting. In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. The semi-mechanistic PK/PD models fit the data well, capturing the time-course profiles of drug concentrations, caspase-3 expression, and cell counts in the 2D and 3DD settings.Conclusion: A novel, sequential triple combination therapeutic regimen was successfully evaluated

  9. Increased frontal electroencephalogram theta amplitude in patients with anorexia nervosa compared to healthy controls

    Directory of Open Access Journals (Sweden)

    Hestad KA

    2016-09-01

    Full Text Available Knut A Hestad,1–3 Siri Weider,3,4 Kristian Bernhard Nilsen,5–7 Marit Sæbø Indredavik,8,9 Trond Sand7,10 1Department of Research, Innlandet Hospital Trust, Brumunddal, Norway; 2Department of Public Health, Hedmark University of Applied Sciences, Elverum, Norway; 3Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology (NTNU, Trondheim, Norway; 4Department of Psychiatry, Specialised Unit for Eating Disorder Patients, Levanger Hospital, Health Trust Nord-Trøndelag, Levanger, Norway; 5Department of Neuroscience, Norwegian University of Science and Technology (NTNU, Trondheim, Norway; 6Department of Work Psychology and Physiology, National Institute of Occupational Health, Oslo, Norway; 7Department of Neurology, Section for Clinical Neurophysiology, Oslo University Hospital, Ullevål, Oslo, Norway; 8Regional Centre for Child and Youth Mental Health and Child Welfare, Faculty of Medicine, Norwegian University of Science and Technology (NTNU, Trondheim, Norway; 9Department of Child and Adolescent Psychiatry, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 10Department of Neurology and Clinical Neurophysiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway Objective: To conduct a blind study of quantitative electroencephalogram-band amplitudes in patients with anorexia nervosa (AN and healthy controls.Methods: Twenty-one patients with AN and 24 controls were examined with eyes-closed 16-channel electroencephalogram. Main variables were absolute alpha, theta, and delta amplitudes in frontal, temporal, and posterior regions.Results: There were no significant differences between the AN patients and controls regarding absolute regional band amplitudes in µV. Borderline significance was found for anterior theta (P=0.051. Significantly increased left and right frontal electrode theta amplitude was found in AN patients (F3, P=0.014; F4, P

  10. Tantsides Jamaicat vallutamas / Anu Sööt

    Index Scriptorium Estoniae

    Sööt, Anu, 1957-

    2009-01-01

    Rahvusvahelisest lastetantsu konverentsist "Dance and the Child International Conference" Jamaica pealinnas Kingstonis, kus osales Eestist 11 tantsuhuvilist, nende õpetaja ja koreograaf Elo Unt ning projektijuht Jane Miller-Pärnamägi Eesti Tantsuagentuurist. Lisaks Tartu Ülikooli Viljandi Kultuuriakadeemia õppejõud Anu Sööt ja Äli Leijen ning Tallinna Ülikooli koreograafia osakonna õppejõud ja Viljandi huvikooli õpetaja Eve Noormets

  11. Gaasitoru, ujuv saun ning helisevad tuutud / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2008-01-01

    Veneetsia XI arhitektuuribiennaalile kandideerinud tööde tutvustus. Biennaali teemaks on "Majade taga. Arhitektuur väljaspool ehitisi". Eestit esindab projekt "Gaasitoru", autorid Maarja Kask ja Ralf Lõoke arhitektuuribüroost Salto ning skulptor Neeme Külm. Teise koha said Eve Kask, Signe Kivi ja Andrus Kõresaar tööga "Peatus". Kolmas koht läks Villem Tomiste projektile "Veealune Veneetsia"

  12. A Blur track on Mars: how do you top that?

    CERN Multimedia

    Cooke, Rachel

    2003-01-01

    "On the eve of the landing of the Beagle 2 space probe on Mars, one of its instigators, Blur bassist Alex James, talks exclusively about his new-found passion for space 'Talking with scientists makes me feel giddy with excitement. Life on Mars, I mean, come on! How dead do you have to be not to find that interesting?' (1 page).

  13. Uus-Maailma uued kortermajad

    Index Scriptorium Estoniae

    2008-01-01

    Korter endises büroohoones Luha 16 - rekonstrueerimisprojekt Tormi Sooväljalt, korter uues galeriimajas Koidu 60-62/ Komeedi 14 - arhitektid Rein Murula ja Karl Koosa (Rein Murula Arhitektuuribüroo OÜ) ja korter uues büroo- ja kortermajas Villardi 22 - Humana Grupp Arhitektuuri- ja Inseneribüroolt. Kommenteerivad arhitektid Peeter Tambu ja Eve Arpo ning kinnisvara maakler Rando Vanaveski

  14. A general model for use in internal dosimetry

    International Nuclear Information System (INIS)

    Johnson, J.R.; Carver, M.B.

    1981-01-01

    A model is described that combines the International Commission on Radiological Protection's Task Group on Lung Dynamics' Model, Eve's model for transport of material through the gastro-intestinal tract and a compartment model for the organs. Differential equations for this model are given, which include urinary and fecal excretion rates, and the method used to obtain solutions to these equations is described. (author)

  15. Tallinna XIII graafikatriennaali grand prix' pälvis leedu graafik Egle Kuckaite

    Index Scriptorium Estoniae

    2004-01-01

    Kolm võrdset preemiat: Sang-gon Chung Lõuna-Koreast, Krishs Salmanis Lätist ja Joanne Soroka Shotimaalt. Diplomid: Anonymous Boh ja Eve Kiiler Eestist, Pete Nevin Inglismaalt, Hanna Oinonen Soomest ja venetsueela-soome kunstnik Sandra Vina de Karila. Tallinna linna preemia: John Smith (Marko Mäetamm & Kaido Ole) Eestist. Eesti Kunstimuuseumi preemia: Markus Lampinen Soomest. Eesti Panga preemia: Leonards Laganovskis Lätist

  16. Miks läheb üks suur inimene lõpuks ikkagi kooli tagasi? / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne, 1971-

    2012-01-01

    Elukestva õppe rahvusvahelise teadusuuringu, milles osales 13 riiki, tulemustest selgub, et täiskasvanud õpivad eesmärgiga teha oma tööd paremini ja saada kõrgemat palka. Selgitusi jagavad rahvusvahelise teadusprojekti Lifelong Learning 2010 (LLL2010) töögrupi liige, Tallinna Ülikooli rahvusvaheliste ja sotsiaaluuringute instituudi teadur Eve-Liis Roosmaa ja LLL2010 koordinaator, professor Ellu Saar

  17. Miks läheb üks suur inimene lõpuks ikkagi kooli tagasi? / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne, 1971-

    2011-01-01

    Elukestva õppe rahvusvahelise teadusuuringu, milles osales 13 riiki, tulemustest selgub, et täiskasvanud õpivad eesmärgiga teha oma tööd paremini ja saada kõrgemat palka. Selgitusi jagavad rahvusvahelise teadusprojekti Lifelong Learning 2010 (LLL2010) töögrupi liige, Tallinna Ülikooli rahvusvaheliste ja sotsiaaluuringute instituudi teadur Eve-Liis Roosmaa ja LLL2010 koordinaator, professor Ellu Saar

  18. Cellular response to 5-fluorouracil (5-FU in 5-FU-resistant colon cancer cell lines during treatment and recovery

    Directory of Open Access Journals (Sweden)

    Kravik Katherine L

    2006-05-01

    periods and a recovery time of 22 days. Mitotic activity ceased in response to drug treatment for all cell lines, consistent with down-regulation of mitosis-regulatory genes. Differential expression in response to 5-FU treatment was demonstrated for genes involved in regulation of nucleotide binding/metabolism (ATAD2, GNL2, GNL3, MATR3, amino acid metabolism (AHCY, GSS, IVD, OAT, cytoskeleton organization (KRT7, KRT8, KRT19, MAST1, transport (MTCH1, NCBP1, SNAPAP, VPS52, and oxygen metabolism (COX5A, COX7C. Conclusion Our gene expression data suggest that altered regulation of nucleotide metabolism, amino acid metabolism, cytoskeleton organization, transport, and oxygen metabolism may underlie the differential resistance to 5-FU seen in these cell lines. The contributory roles to 5-FU resistance of some of the affected genes on these pathways will be assessed in future studies.

  19. 'Nobody teases good girls': A qualitative study on perceptions of sexual harassment among young men in a slum of Mumbai.

    Science.gov (United States)

    Zietz, Susannah; Das, Madhumita

    2017-06-05

    Young adulthood is a key period in which gender norms are solidified. As a result, young women are particularly vulnerable to gender-based violence. In Delhi, over 90% of women have ever experienced sexual violence in public spaces. Sexual harassment of girls and women in public spaces is commonly named 'eve teasing' in India. Experience of sexual harassment in public spaces has been found to be associated with restricted mobility, interrupted education, and early age at marriage. Little is known about men's perspectives on eve teasing and how they believe it affects women and girls. This study fills that gap through qualitative research to explore the attitudes and perceptions of adolescent boys and young men on this topic. Ten focus group discussions were conducted in two slum communities in Mumbai. Coding and thematic analysis were performed. We identified themes of acceptance of harassment, weak sanctions, traditional gender norms supportive of harassment, and ideologies of male sexual entitlement. Many of the perceived risk and protective factors for sexual harassment in public spaces are operationalised at the community level. Community mobilisation is necessary in designing interventions focused on the primary and secondary prevention of sexual harassment.

  20. El Dia de la Independencia, September 16, 1810: El Grito de Dolores (Independence Day, September 16, 1810: The Cry of Dolores).

    Science.gov (United States)

    Oakland Unified School District, CA.

    Each year on the eve of September 16, when the President of the Republic of Mexico has rung the church bell that once hung in the belfry at the Church of Our Lady of Sorrows in the small town of Dolores Hidalgo, he has once more proclaimed Independence Day. When Father Miguel Hidalgo y Costilla rang that same bell on September 16, 1810, he rang it…

  1. Eesti keha kate / Milla Mägi

    Index Scriptorium Estoniae

    Mägi, Milla, 1949-

    2005-01-01

    Konkursist "Eesti keha kate", mille eesmärk oli ärgitada tegema moodsaid rõivaid rahvakunsti ja rahvusliku käsitöötraditsiooni vaimus. I preemia - Liisa Murdvee kangastelgedel kootud kaltsumaterjalist mantel ja jakk, II - Tiina Reeseni rahvuslik komplekt emale ja tütrele, V - Eve Sisa tikandiga korsett, "Kodukolde" auhind - Aide Leit-Lepmetsa Haapsalu pitsi motiividel pruutkleit. 6 värv. ill

  2. Kaunis ja õudne : Raamaturida / Arno Oja

    Index Scriptorium Estoniae

    Oja, Arno, 1950-

    1995-01-01

    Beer, Natalie. Meister Mathis : Matthias Grünewaldi romaan; Pezold, Leopold. Kolme Eestimaa kunstniku rännuaastad; Vint, Maara. Vint, Eve-Maria. Võlulehvik; Seton, Anya. Katherine, 2.osa; Suosalmi, Kerttu-Kaarina. Õnnekütt; Herriott, James. Koerajutud; Laos, Ester. Õhtuks koju; Ewers, Hanns Heinz. Alraune; King, Stephen. Raamatukogupolitseinik; Pabut, Talvo. Surma suflöör; Loon, Paul van. Õuduste käsiraamat

  3. The Banning of You and Machines: Competing Discourses of Educational Technology during the New Deal

    Science.gov (United States)

    Cisneros, Jes R.

    2008-01-01

    While the spectacle of book burnings in Nazi Germany was something that most Americans recoiled from in the 1930s, by the end of the decade, on the eve of America's entry into the Second World War, the symbolic power of destroying books by fire was unfortunately something that certain Americans were not above seizing upon. In the 1930s and 1940s,…

  4. Krakówi graafikasügis / Anne Untera

    Index Scriptorium Estoniae

    Untera, Anne, 1951-

    2009-01-01

    16. septembril avatud Krakówi rahvusvahelisest graafikatriennaalist. Grand prix läks poola graafikule Joanna Piechile. Läti graafik Guntars Sietiņš pälvis Varssavi kunstiakadeemia rektori auhinna. Eestit esindavad peanäitusel Ülle Marks, Benjamin Vasserman ja Eve Kask, satelliitnäitusel "PrintArt" Katowices Tiiu Prisko ja Mati Veermets ning kutsutud osalejatega satelliitnäitusel Torunis Evi Tihemets

  5. An investigation on the effect of cognitive emotion regulation strategies on job satisfaction

    OpenAIRE

    Somayeh Shahba; Seyed Mehdi Alvani; Shams Alsadat Zahedi; Gholamreza Memarzadeh

    2014-01-01

    This paper examined the effects of cognitive emotion regulation on employees’ job satisfaction. In this survey, Questionnaire and the questions were divided into two categories of cognitive emotion regulation and job satisfaction. To measure cognitive emotion regulation, including unadjusted emotion regulation strategies and adjusted strategies, 36 items questionnaire was used originally developed by Garnefski et al. (2001) [Garnefski, N., Kraaij, V., & Spinhoven, P. (2001). Negative life eve...

  6. The Coast Guard Proceedings of the Marine Safety and Security Council. Volume 72, Number 4, Winter 2015-2016

    Science.gov (United States)

    2016-04-13

    National Drug Threat Assessment reported that the annual economic cost of controlled prescription drug non-medical use (use beyond that of...scenario: On a clear Tuesday eve- ning, an outbound small coastal freight ship collides with an inbound offshore supply vessel while navigating a bend...NMCProceedings@uscg.mil Website: www.uscg.mil/proceedings Safety Management Systems Waterways: America’s Economic Engine Recreational Boating Safety i

  7. Näitused / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    1998-01-01

    Rotermanni Soolaladu: "Cweesti" (maastikuarhitektuur- ruum mere ja maa piiril); Tarbekunstimuuseum: "Pro Arte" (soome nüüdisaegse käsitöö näitus); Linnagalerii Tallinnas: Eve Kask "29 1Ü2"; Sammas-galerii: Rene Kari maalid; Kunstihoone galerii: Anne Türn "Hundid" (keraamika); Tammsaare muuseum. Karl Manbergi maalid ja pisiplastika (1914 Tallinn - 1993 Sidney); Eesti Loodusmuuseum: Marielle Liiveti maalid ja kompositsioonid; Raatus-galerii. "Euroopa koolis".

  8. Jewell in China, 1910-1914: Education of a Missionary Woman for School Administration

    Science.gov (United States)

    Scales, T. Laine; Tang, Agnes

    2014-01-01

    On the eve of her birthday, August 14, 1904, the young Jewell Legett recorded in her diary that she had "been feeling so strange today … 20 years old! What an age it is! Just the time to be a girl and learn to live" (Legett 1904). Her summer vacation from the 1903-1904 term at Baylor University was spent with her parents and brothers in…

  9. Conspicuous by Its Absence

    Institute of Scientific and Technical Information of China (English)

    JOSEPH KIRSCHKE

    2010-01-01

    @@ This year, I'm told, was a bit different: in the interest of not insulting millions of struggling Americans, Santa and his reindeer touched down very lightly in the United States last month. New Year's Eve, meanwhile, appears to have left most Americans in a slightly more jovial mood with the hope that-if nothing else-2010 may just possibly be an improvement over 2009.

  10. Physician experiences and preferences in the treatment of HR+/HER2− metastatic breast cancer in the United States: a physician survey

    International Nuclear Information System (INIS)

    Lin, Peggy L.; Hao, Yanni; Xie, Jipan; Li, Nanxin; Zhong, Yichen; Zhou, Zhou; Signorovitch, James E.; Wu, Eric Q.

    2015-01-01

    Sequential endocrine therapy (ET) is recommended for postmenopausal women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) metastatic breast cancer (mBC) and without visceral symptoms. Chemotherapy (CT) can be considered after sequential ETs, but is associated with adverse side effects. We assessed physicians' preferences and self-reported prescribing patterns for ET and CT in the treatment of HR+/HER2− mBC at community practices in the United States. Community-based oncologists/hematologists from a nationwide online panel who treated postmenopausal women with HR+/HER2− mBC were invited to complete a survey, blinded to the identity of study sponsor. Treatment preferences were collected by treatment class of ET-based regimens versus CT and by agent for postmenopausal HR+/HER2− mBC patients after prior nonsteroidal aromatase inhibitor use in the adjuvant or mBC setting. Among 213 physicians who completed the survey, 78% were male, 71% were based in small/intermediate practices (2–9 oncologists/subspecialists), 55% had >10 years of experience, and 58% referred to the National Comprehensive Cancer Network Guidelines when treating mBC. Among first-line ETs, anastrozole was the most frequently used treatment (35%), followed by everolimus-based (EVE, 34%) and fulvestrant-based (FUL, 15%) therapy. After first-line ET, the most preferred second- and third-line treatments were ET monotherapy (48% and 39%), ET combination therapy (31% and 19%), and CT monotherapy (13% and 30%). Comparing EVE versus FUL, physicians preferred EVE in all lines but first line. Efficacy was the most important consideration for treatment choice. Physicians prescribed CT in early lines mainly because of visceral symptoms. This survey of treatment patterns for HR+/HER2− mBC in community practice suggested that after first-line ET, ET mono- or combination therapy was commonly used for the second- and third-line treatments and CT

  11. Confiabilidade do relato de eventos de vida estressantes em um questionário autopreenchido: Estudo Pró-Saúde

    Directory of Open Access Journals (Sweden)

    Lopes Claudia S

    2001-01-01

    Full Text Available OBJETIVO: Avaliar a confiabilidade do relato de eventos de vida estressantes (EVE, integrantes de um questionário multidimensional preenchido por uma amostra de funcionários de uma universidade pública. MÉTODOS: Utilizou-se um desenho de estudo de confiabilidade teste-reteste, com um intervalo de duas semanas entre as duas aferições, como parte de um estudo-piloto realizado em uma amostra de 192 funcionários contratados de uma universidade pública no Rio de Janeiro. A avaliação dos EVE foi feita por meio de perguntas fechadas, com respostas dicotômicas, cobrindo os seguintes eventos nos 12 meses anteriores: doença séria; internação hospitalar; morte de parente próximo; problemas financeiros severos; mudança forçada de moradia; separação/divórcio; agressão física; assalto/roubo; e experiência de diversos tipos de discriminação. A análise da confiabilidade foi feita com estratificação por gênero e escolaridade dos respondentes, utilizando-se o coeficiente kappa. RESULTADOS: Os resultados mostraram uma confiabilidade "substancial" a "quase perfeita" (kappa entre 0,62 e 1,00, para homens e mulheres, nas questões referentes a: internação hospitalar, falecimento de parente próximo, dificuldades financeiras severas, rompimento de relação amorosa e assalto/roubo. Para a maioria do eventos, houve diferenças importantes nos valores do kappa segundo o grau de escolaridade dos respondentes; para a maioria das perguntas, o grupo com maior escolaridade obteve melhores resultados. CONCLUSÃO: Os achados sugerem que a utilização de perguntas discretas sobre EVE em um questionário para autopreenchimento é adequada, com a maioria das questões apresentando boa estabilidade quando aplicada a adultos de diferentes níveis de escolaridade.

  12. SUNCT syndrome: The materialization of a headache syndrome

    Directory of Open Access Journals (Sweden)

    Ottar Sjaastad

    2008-10-01

    Full Text Available Ottar SjaastadDepartment of Neurology, St. Olav´s Hospital, 7006 Trondheim University Hospitals, Trondheim, NorwayAbstract: Shortlasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing (SUNCT syndrome is a rare headache, described by our group in 1989. This overview presents our early studies of SUNCT pathogenesis. Due to the conspicuous ictal, ocular phenomena, ie, conjunctival injection and tearing, our studies started out with ocular parameters: intraocular pressure and corneal indentation pulse amplitudes, both of which showed clear ictal increments, symptomatic side. Beat-to-beat, noninvasive blood pressure measurements during attack showed instant, systolic blood pressure rise and corresponding pulse rate decrease. Carotid body, the principal peripheral chemoreceptor, seemed to function normally. The middle cerebral artery was dilated during attacks, particularly on the symptomatic side. Finally, some viewpoints are added regarding terminology. SUNCT is a workable and accepted term. There does not seem to be any need for another, fictitious term to describe the same clinical picture.Keywords: SUNCT syndrome, intraocular blood flow, intraocular pressure, median artery blood flow, carotid body function, hypothalamic stimulation

  13. Sotsiaalne kapital ja majandusareng Euroopa Liidu kandidaatmaades / Eve Parts

    Index Scriptorium Estoniae

    Parts, Eve, 1970-

    2003-01-01

    Ülevaade sotsiaalse kapitali tasemest EL-i kandidaatmaades, kas ja kuidas mõjutab kandidaatriikide sotsiaalse kapitali taset liitumine EL-iga, kuidas oleks võimalik sotsiaalse kapitali akumulatsiooni kiirendada. Tabelid

  14. Tumedanahaline Eesti kodanik politsei silmis kahtlane element / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2005-01-01

    Politsei ei lubanud Briti peaministri visiidi ajal tumedanahalist pakistanlasest Eesti kodanikku Tahir Husseini Raekoja platsile. Vt. samas: Kadri Paas. Suurbritannia peaministrit sõidutas Tallinnas soomlane

  15. Dan Põldroos mängib Eesti superkangelast / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2001-01-01

    Eestlaste filmigrupp filmis Tuneesias esimest osa kodumaisest koomilisest märuliseriaalist "Kodumaa parim poeg ehk eriagent 1188" : stsenarist Toomas Kall : režissöör Peeter Simm : peaosades näitleja ja sarja produtsent Dan Põldroos ning teine režissöör Ervin Õunapuu

  16. Negotiating Marriage on the Eve of Human Rights | Besendahl ...

    African Journals Online (AJOL)

    African Sociological Review / Revue Africaine de Sociologie. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 8, No 1 (2004) >. Log in or Register to get access to full text downloads.

  17. Eesti õpetajaharidus - kas edasiminek või paigalseis? / Eve Eisenschmidt

    Index Scriptorium Estoniae

    Eisenschmidt, Eve, 1963-

    2007-01-01

    Suurbritannia programmist "Teach First", mis pakub praktilisel tööl põhinevat õpetaja- ning liidrikoolitust. Eestis on käivitatud analoogiline programm "Noored kooli", milles osalevad Tallinna Ülikooli õppejõud

  18. Tudengid jämmisid dzhässitippudega / Eve Tisler

    Index Scriptorium Estoniae

    Tisler, Eve

    2005-01-01

    Eesti Muusikaakadeemia eestvedamisel toimunud Läänemeremaade muusikakõrgkoolide ühingu ABAM (Association of Baltic Academies of Music) üliõpilaste rahvusvahelisest improvisatsioonilisest suvekursusest "Crossing Borders" Tallinnas

  19. Political blackmail – the eve of the global catastrophe

    Directory of Open Access Journals (Sweden)

    Gennadii Vasil’evich Osipov

    2014-09-01

    Full Text Available The article by the leading Russian sociologist and political scientist, who has been studying Russia-U.S. relations for decades, raises an acute issue concerning the necessity of immediate cessation of confrontation between the U.S. and Russia and transition to joint control over the processes going on in the world, and establishment of the multipolar model of the global community. The author provides numerous examples of interaction between the superpowers and the newly emerged countries, former Soviet republics; he shows that particular threat comes from the quasi-states of the former USSR, who seek to fuel the U.S.-Russian confrontation for their own selfish purposes. This policy was manifested especially clearly in the actions of the “Maidan” authorities in Ukraine, who launched the armed terror against its own people in the East of the country to accommodate the U.S. interests and the NATO alliance controlled by this country. The author believes that the response of Russia to such hostile actions of the USA and their Ukrainian proteges should be adequate; it should be composed and peacekeeping, but when the “red” line is crossed – hard and adamant. The author believes that, in connection with the existing situation, the issue of myth-making is coming to the fore. One should be more resolute in reviewing the myths that have nothing to do with the truth, in particular, those concerning the “unbreakable Slavic unity”. The historical memory of inter-ethnic relations between the Russians and their neighbors should be restored in full, without ignoring the facts that are “inconvenient” for the mythology. It is time for Russia to abandon (at least temporarily its missionary work and selflessness in its relations with Eastern European neighbors, and start building these relations solely on the basis of mutual benefit and respect of mutual obligations

  20. Häbi, professor, teil on Gefilus kapis / Eve Kruuse

    Index Scriptorium Estoniae

    Kruuse, Eve,d1959-

    2008-01-01

    Tartu Ülikooli professor Marika Mikelsaar võitis läinud kuul koos kolleegidega (Tiiu Kullisaar, Epp Songisepp, Hedi Annuk ja Mihkel Zilmer) Soulis ülemaailmse naisleiutajate konkursil ME-3 bakteri avastamise ja probiootikuks arendamise eest kuldmedali